title: Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.
abstract: An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines when stored, with other medications, in Venalink blister packs (monitored dosage system) for periods of up to 35 days. Chromatographic separation was achieved on a reversed-phase C(12) column with an isocratic mixture of methanol, water and acetic acid as the mobile phase. The method was validated regarding: accuracy, precision, detection limits, quantification limits, specificity and robustness.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
authors.forename: Manal S
authors.initials: MS
authors.lastname: Elmasry
authors.forename: Ian S
authors.initials: IS
authors.lastname: Blagbrough
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rowan
authors.forename: Hanaa M
authors.initials: HM
authors.lastname: Saleh
authors.forename: Afaf Aboul
authors.initials: AA
authors.lastname: Kheir
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rogers
mesh_terms: D001241:Aspirin / Q000032:analysis; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage; D013058:Mass Spectrometry; D008509:Medication Systems; D019804:Mesalamine / Q000032:analysis; D010627:Phenethylamines / Q000032:analysis*; D019338:Polypharmacy; D012459:Salicylates / Q000032:analysis*; D012460:Sulfasalazine / Q000032:analysis*; D013607:Tablets; D013678:Technology, Pharmaceutical; D013997:Time Factors
chemical_list: D002214:Capsules; D010627:Phenethylamines; D012459:Salicylates; D013607:Tablets; D012460:Sulfasalazine; D019804:Mesalamine; C005096:mebeverine; D001241:Aspirin