title: Hepcidin in anemia of chronic heart failure.
abstract: Anemia is a common finding among patients with chronic heart failure (HF). Although comorbidities, such as kidney failure, might contribute to the pathogenesis of anemia, many patients with HF do not have any other obvious etiology for their anemia. We investigated whether anemia in HF is associated with an elevation in hepcidin concentration. We used time-of-flight mass spectrometry to measure hepcidin concentration in urine and serum samples of patients with HF and in control subjects. We found that the concentration of hepcidin was lower in urine samples of patients with HF compared with those of control subjects. Serum hepcidin was also reduced in HF but was not significantly lower than that in controls. There were no significant differences between hepcidin levels in patients with HF and anemia compared with patients with HF and normal hemoglobin level. We concluded that hepcidin probably does not play a major role in pathogenesis of anemia in patients with chronic HF.
authors.affiliation: Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Divakaran
authors.forename: Sachin
authors.initials: S
authors.lastname: Mehta
authors.forename: David
authors.initials: D
authors.lastname: Yao
authors.forename: Saamir
authors.initials: S
authors.lastname: Hassan
authors.forename: Steven
authors.initials: S
authors.lastname: Simpson
authors.forename: Erwin
authors.initials: E
authors.lastname: Wiegerinck
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Mann
authors.forename: Vahid
authors.initials: V
authors.lastname: Afshar-Kharghan
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood* / Q000473:pathology; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000097:blood*; D064451:Hepcidins; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins