title: Identification of dihydropyridines that reduce cellular tau levels.
abstract: A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.
authors.affiliation: Department of Pathology and the Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI 48109, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Evans
authors.forename: Umesh K
authors.initials: UK
authors.lastname: Jinwal
authors.forename: Leah N
authors.initials: LN
authors.lastname: Makley
authors.forename: Chad A
authors.initials: CA
authors.lastname: Dickey
authors.forename: Jason E
authors.initials: JE
authors.lastname: Gestwicki
mesh_terms: D003500:Cyclization; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D016875:tau Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D004095:Dihydropyridines; D016875:tau Proteins; C038806:1,4-dihydropyridine