title: Bone mineral density in prediabetic men.
abstract: BACKGROUND
  There are many studies regarding the effects of insulin on bone metabolism and changes in bone mineral density (BMD) in the setting of diabetes. The effect of prediabetes on BMD is not known.
  
  
  METHODS
  A total of 802 men participated in the Korea Rural Genomic Cohort Study (in Geumsan County). According to the results of an oral glucose tolerance test, subjects were classified into normal, prediabetic, and diabetic categories. One hundred twenty-four subjects diagnosed with type 2 diabetes were excluded, leaving 678 subjects for the study inclusion. BMD was estimated with a quantitative ultrasonometer.
  
  
  RESULTS
  The average BMD T scores of normal and prediabetic subjects were -1.34 ± 1.42 and -1.33 ± 1.30, respectively; there was no significant difference in the BMD T scores between these groups. The BMD T score was inversely associated with age and positively correlated with body weight, body mass index, total cholesterol, low density lipoprotein cholesterol, and HbA1c. On multiple linear regression analysis, low density lipoprotein cholesterol was the only statistically significant variable for prediabetes (β = 0.007, P = 0.005). On the stepwise regression analysis, age (β = -0.026, P < 0.001), the body mass index (β = 0.079, P < 0.001), and low density lipoprotein cholesterol (β = 0.004, P = 0.016) were significant variables for prediabetes.
  
  
  CONCLUSIONS
  There was no significant difference in the BMD T score between the normal and prediabetic subjects. Further studies are needed regarding the association of fracture risk and changes in BMD with the development of overt diabetes.
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Yun Hyeong
authors.initials: YH
authors.lastname: Lee
authors.forename: Kyoung Hye
authors.initials: KH
authors.lastname: Jung
authors.forename: Min Kyeong
authors.initials: MK
authors.lastname: Kim
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Jang
authors.forename: Tae Kyun
authors.initials: TK
authors.lastname: Kim
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Jo
authors.forename: Minho
authors.initials: M
authors.lastname: Shong
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Lee
authors.forename: Bon Jeong
authors.initials: BJ
authors.lastname: Ku