title: Determinants of success in treating cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To determine the important factors affecting the long-term failure rate of treatment for cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  Multivariate analysis of prospectively collected clinical data.
  
  
  METHODS
  Colposcopy clinic in a university teaching hospital.
  
  
  METHODS
  A total of 2455 consecutive women treated for CIN for the first time between 1 January 1989 and 31 December 2004 using excisional techniques.
  
  
  METHODS
  The data were obtained from a clinical database into which information had been entered prospectively. Data on community follow-up were obtained from the national Exeter database of cervical screening results. The parameters studied were age, parity, severity of the lesion, extent to which the lesion involved the endocervical canal, seniority of the surgeon, type of treatment, anaesthesia used, dimensions of the treatment biopsy specimen, number of treatment biopsy fragments and completeness of excision.
  
  
  METHODS
  High-grade post-treatment cervical disease detected by biopsy or cytology.
  
  
  RESULTS
  Univariate analysis eliminated several potential factors and identified interactions between some factors. Multivariate analysis identified the grade of disease (P < 0.001) and the extent to which the lesion involved the endocervical canal (P =0.008) as the most important determinants of high-grade post-treatment disease. Of the factors which the surgeon could control, depth of biopsy (P =0.002) and completeness of excision (P = 0.007) were the most important.
  
  
  CONCLUSIONS
  This study confirms that clear margins are important to reduce the failure rate of excisional treatment for CIN. An adequate depth of treatment is important when the lesion involves the endocervical canal.
authors.affiliation: Department of Obstetrics and Gynaecology, Imperial College London, Hammersmith Hospital, London, UK. s.ghaem-maghami@imperial.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Ghaem-Maghami
authors.forename: D
authors.initials: D
authors.lastname: De-Silva
authors.forename: M
authors.initials: M
authors.lastname: Tipples
authors.forename: Sj
authors.initials: S
authors.lastname: Lam
authors.forename: K
authors.initials: K
authors.lastname: Perryman
authors.forename: Wp
authors.initials: W
authors.lastname: Soutter
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D012307:Risk Factors; D017211:Treatment Failure; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*