title: Metabolic abnormalities in adolescents with polycystic ovary syndrome in south China.
abstract: BACKGROUND
  Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential risk factors contributed to these health risks.
  
  
  METHODS
  Anthropometric measurements and biochemical parameters were evaluated in 128 adolescents with PCOS and their age- and BMI-matched controls.
  
  
  RESULTS
  The prevalence of pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome in adolescents with PCOS was 11.7%, 46.9%, 29.7%, 22.7% and 4.7%, respectively. 16.3%, 74.4%, 67.4%, 39.5% and 14% of the PCOS subjects with BMI > 85th had pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome, whereas 9.4%, 32.9%, 10.6%, 14.1% and 0% of the PCOS subjects with BMI < 85th had such disturbances.
  
  
  CONCLUSIONS
  Adolescents with PCOS in South China had more metabolic abnormalities than their age- and BMI-matched non-PCOS counterparts. Obesity could worsen insulin resistance, hyperinsulinemia and metabolic syndrome in PCOS adolescents.
authors.affiliation: Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.forename: Renmin
authors.initials: R
authors.lastname: Ni
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.forename: Lili
authors.initials: L
authors.lastname: Huang
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Mo
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002681:China; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000453:epidemiology; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000453:epidemiology; D009765:Obesity / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*; D011236:Prediabetic State / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult