title: Immune surveillance of the normal human CNS takes place in dependence of the locoregional blood-brain barrier configuration and is mainly performed by CD3(+)/CD8(+) lymphocytes.
abstract: Despite the blood-brain barrier (BBB) the human CNS is continuously screened by blood-derived immunological cells. In certain brain areas the local BBB configuration grants passage of large molecules, whereas others are better shielded. We investigated whether these regional BBB compositions are paralleled by differences in the degree of cellular immunosurveillance by investigating tissue from 23 normal human brains for several CD markers, FoxP3, granzyme B, and perforin. Our results provide evidence that immunosurveillance is associated with locoregional BBB configuration and is mainly performed by CD3(+)/CD8(+)/granzyme B(-)/perforin(-) lymphocytes.
authors.affiliation: Institute of Brain Research, University of Tuebingen, Medical School, Tübingen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Loeffler
authors.forename: Klaus
authors.initials: K
authors.lastname: Dietz
authors.forename: Ariane
authors.initials: A
authors.lastname: Schleich
authors.forename: Holger
authors.initials: H
authors.lastname: Schlaszus
authors.forename: Manuel
authors.initials: M
authors.lastname: Stoll
authors.forename: Richard
authors.initials: R
authors.lastname: Meyermann
authors.forename: Michel
authors.initials: M
authors.lastname: Mittelbronn
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001812:Blood-Brain Barrier / Q000166:cytology / Q000276:immunology*; D017252:CD3 Complex / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002490:Central Nervous System / Q000098:blood supply* / Q000166:cytology / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D055815:Young Adult
chemical_list: D017252:CD3 Complex; D016827:CD8 Antigens