title: Role of NF-κB in the skeleton.
abstract: Since the discovery that deletion of the NF-κB subunits p50 and p52 causes osteopetrosis in mice, there has been considerable interest in the role of NF-κB signaling in bone. NF-κB controls the differentiation or activity of the major skeletal cell types - osteoclasts, osteoblasts, osteocytes and chondrocytes. However, with five NF-κB subunits and two distinct activation pathways, not all NF-κB signals lead to the same physiologic responses. In this review, we will describe the roles of various NF-κB proteins in basal bone homeostasis and disease states, and explore how NF-κB inhibition might be utilized therapeutically.
authors.affiliation: Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. novack@wustl.edu
authors.forename: Deborah Veis
authors.initials: DV
authors.lastname: Novack
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D019902:Chondrocytes / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism / Q000502:physiology*; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D021122:Protein Subunits / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B; D021122:Protein Subunits