title: Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice.
abstract: We have previously described diminished uterine progesterone response and increased uterine sensitivity to inflammation in adult female mice with a history of developmental exposure to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin). Since parturition in mammals is an inflammatory process mediated in part by a decline in progesterone action, toxicant-mediated disruption of progesterone receptor (PR) expression at the maternal-fetal interface would likely impact the timing of birth. Therefore, in the current study, we examined pregnancy outcomes in adult female mice with a similar in utero exposure to TCDD. We also examined the impact of in utero TCDD exposure of male mice on pregnancy outcomes in unexposed females since the placenta, a largely paternally derived organ, plays a major role in the timing of normal parturition via inflammatory signaling. Our studies indicate that developmental exposure of either parent to TCDD is associated with preterm birth in a subsequent adult pregnancy due to altered PR expression and placental inflammation.
authors.affiliation: Women's Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States.
authors.forename: Tianbing
authors.initials: T
authors.lastname: Ding
authors.forename: Melinda
authors.initials: M
authors.lastname: McConaha
authors.forename: Kelli L
authors.initials: KL
authors.lastname: Boyd
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Osteen
authors.forename: Kaylon L
authors.initials: KL
authors.lastname: Bruner-Tran
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic / Q000187:drug effects*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D018812:Paternal Exposure / Q000009:adverse effects*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010922:Placenta Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011247:Pregnancy; D047928:Premature Birth / Q000139:chemically induced*; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D012333:RNA, Messenger / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D013723:Teratogens / Q000633:toxicity*
chemical_list: D000072317:Polychlorinated Dibenzodioxins; D012333:RNA, Messenger; D011980:Receptors, Progesterone; D013723:Teratogens