title: Probing the role of the bridging C509 between the [Fe4S4] cubane and the [Ni(p)Ni(d)] centre in the A-cluster of acetyl-coenzyme A synthase.
abstract: The A-cluster of acetyl-coenzyme A synthase consists of an [Fe(4)S(4)] cubane bridged to a [Ni(p)Ni(d)] centre via C509 cysteinate. The bridging cysteinate, which could be substituted by histidine imidazole, mediates "communication" between the [Fe(4)S(4)] cubane and the [Ni(p)Ni(d)] centre during the synthesis of acetyl-coenzyme A.
authors.affiliation: Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Tianlei
authors.initials: T
authors.lastname: Ying
authors.forename: Pingwei
authors.initials: P
authors.lastname: Li
authors.forename: Zhong-Xian
authors.initials: ZX
authors.lastname: Huang
authors.forename: Xiangshi
authors.initials: X
authors.lastname: Tan
mesh_terms: D019943:Amino Acid Substitution; D001665:Binding Sites; D003066:Coenzyme A Ligases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry; D005296:Ferrous Compounds / Q000737:chemistry*; D007700:Kinetics; D009532:Nickel / Q000737:chemistry*; D017434:Protein Structure, Tertiary
chemical_list: D005296:Ferrous Compounds; D009532:Nickel; D003066:Coenzyme A Ligases; C101958:acetate-CoA ligase (ADP-forming); D003545:Cysteine; C022597:ferrous sulfide