title: Increases in Nonspecific Immunoglobulin E and Eosinophils after H. pylori Eradication.
abstract: Helicobacter pylori infection has been reported to be inversely associated with allergic disorders. We by chance experienced a patient with atrophic gastritis who presented marked elevations of both nonspecific serum immunoglobulin E and eosinophil counts after H. pylori eradication. A 49-year-old Japanese man received eradication of H. pylori using lansoprazole 60 mg/day, amoxicillin 1,500 mg/day, and clarithromycin 400 mg/day for 7 days. Serum immunoglobulin E increased to more than four times its pretreatment level, 306 → 485 → 1,325 U/ml, and peripheral eosinophil counts increased to more than three times, 99 → 139 → 298 per μl. Deducing from the current case, H. pylori eradication might develop allergic disorders in some patients.
authors.affiliation: Division of Hematology and Rheumatology, Department of Medicine, Tokyo, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsukawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Gon
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hemmi
authors.forename: Jin
authors.initials: J
authors.lastname: Takeuchi
authors.forename: Shigemasa
authors.initials: S
authors.lastname: Sawada
authors.forename: Izumi
authors.initials: I
authors.lastname: Hayashi