title: Poly(ester urethane) guides for peripheral nerve regeneration.
abstract: A biocompatible and elastomeric PU was synthesized from low-molecular-weight PCL as macrodiol, CMD as chain extender and HDI as chain linker for applications in the field of peripheral nerve repair. PU cast films supported in vitro attachment and proliferation of NOBEC. The in vitro adhesion and proliferation of S5Y5 neuroblastoma cells on the inner surface of uncoated, gelatin- and PL-coated PU guides were compared. Due to their superior in vitro performance, PL-coated PU guides were tested in vivo for the repair of 1.8 cm-long defects in rat sciatic nerves. The progressive regeneration was confirmed by EMG and histological analysis showing the presence of regenerating fibers in the distal stumps.
authors.affiliation: Department of Mechanics, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Chiono
authors.forename: Susanna
authors.initials: S
authors.lastname: Sartori
authors.forename: Alfonsina
authors.initials: A
authors.lastname: Rechichi
authors.forename: Chiara
authors.initials: C
authors.lastname: Tonda-Turo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vozzi
authors.forename: Federico
authors.initials: F
authors.lastname: Vozzi
authors.forename: Mario
authors.initials: M
authors.lastname: D'Acunto
authors.forename: Claudia
authors.initials: C
authors.lastname: Salvadori
authors.forename: Francesca
authors.initials: F
authors.lastname: Dini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barsotti
authors.forename: Fabio
authors.initials: F
authors.lastname: Carlucci
authors.forename: Silvia
authors.initials: S
authors.lastname: Burchielli
authors.forename: Silvia
authors.initials: S
authors.lastname: Nicolino
authors.forename: Chiara
authors.initials: C
authors.lastname: Audisio
authors.forename: Isabelle
authors.initials: I
authors.lastname: Perroteau
authors.forename: Paolo
authors.initials: P
authors.lastname: Giusti
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ciardelli
mesh_terms: D000818:Animals; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004576:Electromyography; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D055595:Mechanical Phenomena / Q000187:drug effects; D051379:Mice; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*; D011091:Polyesters / Q000494:pharmacology*; D011140:Polyurethanes / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013818:Thermogravimetry
chemical_list: D011091:Polyesters; D011140:Polyurethanes; C081821:microthane foam