title: Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of Abies georgei.
abstract: A systematic phytochemical investigation of the aerial parts of Abies georgei yielded nine new and 72 known compounds, including four monoterpenes, four sesquiterpenes, 25 flavonones, 14 lignans, and 34 other chemical constituents. The new compounds included two monoterpenes (1 and 2), two sesquiterpenes (3 and 4), three flavonones (5, 6, and 7), and two other components (8 and 9). Their chemical structures were established on the basis of various spectroscopic data. All the isolates were tested for antitumor and anti-inflammatory activities. The new compound 9,4'-dihydroxy-5,7-dimethoxy-8-methylchalcone (7) demonstrated a moderate antiproliferative effect on QGY-7703 tumor cells (IC (50)  = 17.6 µg/mL). The known compound isoferulaldehyde (67) exhibited the strongest inhibitory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages (IC (50) = 19.0 µg/mL). Abies georgei may be a significant source of beneficial pharmaceutical compounds.
authors.affiliation: Department of Natural Product Chemistry, School of Pharmacy, Second Military University, Shanghai, China.
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Li
authors.forename: Su-Mei
authors.initials: SM
authors.lastname: Li
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Jun-Mian
authors.initials: JM
authors.lastname: Tian
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Feng
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D028202:Abies / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D017705:Lignans; D008070:Lipopolysaccharides; D039821:Monoterpenes; D010936:Plant Extracts; D012717:Sesquiterpenes; D009569:Nitric Oxide