title: Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines.
abstract: We have developed an in-flow process for the synthesis of β-keto esters via the BF(3)·OEt(2)-catalyzed formal C-H insertion of ethyl diazoacetate into aldehydes. The β-keto esters were then condensed with a range of amidines to give a variety of 2,6-substituted pyrimidin-4-ols.
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom.
authors.forename: Hannah E
authors.initials: HE
authors.lastname: Bartrum
authors.forename: David C
authors.initials: DC
authors.lastname: Blakemore
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Moody
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hayes
mesh_terms: D000146:Acids, Carbocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D000146:Acids, Carbocyclic; D004952:Esters; D007659:Ketones; D011743:Pyrimidines