title: Glycopolymer-grafted polystyrene nanospheres.
abstract: The synthesis and characterization of spherical sugar-containing polymer brushes consisting of PS cores onto which chains of sugar-containing polymers have been grafted via two different techniques are described. Photopolymerization in aqueous dispersion using the functional monomer MAGlc and crosslinked or non-crosslinked PS particles covered with a thin layer of photo-initiator yielded homogeneous glycopolymer brushes attached to spherical PS cores. As an alternative, ATRP was used to graft poly-(N-acetylglucosamine) arms from crosslinked PS cores. Deprotection of the grafted brushes led to water-soluble particles that act as carriers for catalytically active gold nanoparticles. These glycopolymer chains show a high affinity to adsorb WGA whereas no binding to BSA or PNA could be detected.
authors.affiliation: Makromolekulare Chemie II, Universität Bayreuth, 95440 Bayreuth, Germany.
authors.forename: André
authors.initials: A
authors.lastname: Pfaff
authors.forename: Vaishali S
authors.initials: VS
authors.lastname: Shinde
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Alexander
authors.initials: A
authors.lastname: Wittemann
authors.forename: Matthias
authors.initials: M
authors.lastname: Ballauff
authors.forename: Axel H E
authors.initials: AH
authors.lastname: Müller
mesh_terms: D000117:Acetylglucosamine / Q000138:chemical synthesis; D000818:Animals; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis / Q000528:radiation effects; D002417:Cattle; D002850:Chromatography, Gel; D005947:Glucose / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D057446:Hydrodynamics; D007700:Kinetics; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D008970:Molecular Weight; D054118:Nanospheres / Q000737:chemistry*; D010316:Particle Size; D058105:Polymerization / Q000528:radiation effects; D011137:Polystyrenes / Q000138:chemical synthesis* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014909:Wheat Germ Agglutinins / Q000737:chemistry
chemical_list: D002241:Carbohydrates; D011137:Polystyrenes; D014909:Wheat Germ Agglutinins; D006046:Gold; D005947:Glucose; D000117:Acetylglucosamine