title: Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: evidence from 15,041 cases and 21,507 controls.
abstract: Published data on the association between prothrombin G20210A polymorphism and coronary artery disease (CAD) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 42 case-control studies including 15,041 cases and 21,507 controls were included in this meta-analysis. Overall, significantly elevated CAD risk was associated with prothrombin G20210A polymorphism (OR, 1.22; 95% CI 1.07-1.40; P=0.003) when 39 eligible studies were pooled into the meta-analysis. In the subgroup analysis, borderline statistically increased risk was found for myocardial infarction in 22 case-control studies (OR, 1.27; 95% CI 1.00-1.61; P=0.05). When stratified by ethnicity, significantly elevated risk was found in Europeans (OR, 1.19; 95% CI, 1.02-1.38; P=0.02). However, no statistical differences were found among Americans and Asians. In summary, this meta-analysis indicated that prothrombin G20210A allele is a low-penetrant risk factor for developing CAD in Europeans.
authors.affiliation: Department of Cardiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Qu-Zhen
authors.initials: QZ
authors.lastname: Ge-Shang
authors.forename: Huan-Chun
authors.initials: HC
authors.lastname: Ni
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
mesh_terms: D044466:Asian People; D003324:Coronary Artery Disease / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D044465:White People
chemical_list: D011516:Prothrombin