title: Synthesis of water soluble, biodegradable, and electroactive polysaccharide crosslinker with aldehyde and carboxylic groups for biomedical applications.
abstract: We report the synthesis and characterization of a polysaccharide crosslinker of tetraaniline grafting oxidized sodium alginate with large aldehyde and carboxylic groups. We demonstrate that this copolymer has the following properties: it is water soluble under any pH, biodegradable, electroactive, and noncytotoxic; it can self-assemble into nanoparticles with large active functional groups on the outer surface; it can crosslink materials with amino and aminoderivative groups like gelatin to form hydrogels, and thus the electroactivity is readily introduced to the materials. This copolymer has potential applications in biomedical fields such as tissue engineering, drug delivery, and nerve probes where electroactivity is required.
authors.affiliation: Key Laboratory on Assisted Circulation, Ministry of Health, Cardiovascular Division, First Affiliated Hospital, Sun Yat-sen University, Guangdong 510089, PR China. wangqinm@mail.sysu.edu.cn
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: He
authors.forename: Junqi
authors.initials: J
authors.lastname: Huang
authors.forename: Siwei
authors.initials: S
authors.lastname: Liu
authors.forename: Guifu
authors.initials: G
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Teng
authors.forename: Qinmei
authors.initials: Q
authors.lastname: Wang
authors.forename: Yugang
authors.initials: Y
authors.lastname: Dong
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000633:toxicity; D000464:Alginates / Q000737:chemistry / Q000633:toxicity; D000814:Aniline Compounds / Q000737:chemistry / Q000633:toxicity; D001673:Biodegradation, Environmental / Q000187:drug effects; D002264:Carboxylic Acids / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D004553:Electric Conductivity; D055664:Electrochemical Techniques; D005780:Gelatin / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry / Q000633:toxicity; D006603:Hexuronic Acids / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing / Q000379:methods*; D008970:Molecular Weight; D053758:Nanoparticles / Q000648:ultrastructure; D010084:Oxidation-Reduction / Q000187:drug effects; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility / Q000187:drug effects; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000464:Alginates; D000814:Aniline Compounds; D002264:Carboxylic Acids; D003432:Cross-Linking Reagents; D006603:Hexuronic Acids; D011134:Polysaccharides; D012996:Solutions; D014867:Water; D020723:Glucuronic Acid; D005780:Gelatin; C023650:aniline