title: An RF-powered wireless multi-channel implantable bio-sensing microsystem.
abstract: An RF-powered wireless three-channel implantable bio-sensing microsystem is developed with blood pressure, EKG, and core body temperature sensing capability for untethered genetically engineered laboratory mice real-time monitoring. A flat silicone blood pressure sensing cuff with a MEMS capacitive pressure sensor is employed to form a novel less-invasive blood pressure sensor, which avoids vessel occlusion, bleeding, and blood clotting associated with the conventional catheter-based sensors. The implantable microsystem can be powered by an adaptively controlled external RF energy source at 4 MHz to ensure a stable on-chip power supply. The overall system dissipates 200 microW and achieves a blood pressure sensing resolution of 1 mmHg within 1 kHz bandwidth, an EKG sensing resolution of 7.4 bits, and a temperature sensitivity of 19 mV/°C measured from 22 °C to 43 °C. A prototype packaged sensor exhibits a weight of 495 mg, which is approximately 2% of a laboratory mouse body mass. On-going research effort is devoted to demonstrate in vivo performance in laboratory animals.
authors.affiliation: University of Utah, Salt Lake City, Utah, USA. darrin.young@utah.edu
authors.forename: Darrin J
authors.initials: DJ
authors.lastname: Young
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D001795:Blood Pressure Determination / Q000295:instrumentation / Q000379:methods; D004562:Electrocardiography / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D051379:Mice; D019736:Prostheses and Implants