title: CMOS/microfluidic Lab-on-chip for cells-based diagnostic tools.
abstract: We describe in this paper cells sensing and manipulation methods, as well as platforms based on Lab-on-chip devices. Among other contributions, new circuit and microfluidic techniques, and packaging methods are proposed for efficient cells manipulation and detection. The proposed devices include high-sensitivity sensing circuits (200 mV/fF), low-pressure liquid injection interfaces (< 0.65 psi), low-voltage manipulation signals, direct-write microfluidic fabrication technique on top of CMOS based capacitive sensors. In addition, several types of electrode arrays (square and L-shaped) are used for the manipulation of various types of cells and particles.
authors.affiliation: Polystim Neurotechnologies Laboratory, Dept. of Elec. Eng., Polytechnique Montréal, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Sawan
authors.forename: M A
authors.initials: MA
authors.lastname: Miled
authors.forename: E
authors.initials: E
authors.lastname: Ghafar-Zadeh
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002477:Cells / Q000378:metabolism*; D019937:Diagnostic Techniques and Procedures; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D025802:Electric Capacitance; D004566:Electrodes; D004582:Electronics, Medical; D004586:Electrophoresis; D008670:Metals / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D010087:Oxides / Q000737:chemistry*; D011312:Pressure; D012666:Semiconductors
chemical_list: D004129:Dimethylpolysiloxanes; D008670:Metals; D010087:Oxides