title: Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica.
abstract: Five new dimeric sesquiterpene lactones, neojaponicone A (1) and japonicones M-P (2-5) were isolated from the aerial part of Inula japonica. Neojaponicone A (1) has an unprecedented carbon skeleton with an unusual valerolactone system formed between a guaianolide and an eudesmane. The structure and absolute configuration of 1 were established by extensive analysis of spectroscopic data and computational approaches.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Li Yan
authors.initials: LY
authors.lastname: Wang
authors.forename: Jia Xian
authors.initials: JX
authors.lastname: Zhu
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Jian Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Xiao Feng
authors.initials: XF
authors.lastname: Liu
authors.forename: Hong Lin
authors.initials: HL
authors.lastname: Li
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D019281:Dimerization; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D007783:Lactones; D012717:Sesquiterpenes; C557743:neojaponicone A; D002244:Carbon