title: [Thromboxane-prostacyclin balance and platelet aggregability in patients with minor cardiac abnormalities].
abstract: OBJECTIVE
  To reveal changes in the thromboxane-prostacyclin balance and platelet aggregability in patients with various variants of minor cardiac abnormalities.
  
  
  METHODS
  Six-five patients (mean age 23.0 +/- 0.7 years) with minor cardiac abnormalities and 10 apparently healthy individuals were examined. Platelet aggregation induced by adrenaline, adenosine diphosphate, collagen) and the plasma levels of thromboxane B2 (TxB) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) were determined.
  
  
  RESULTS
  Patients with abnormally located chordae (ALC) were found to have no deviations in the thromboxane-prostacyclin balance and platelet aggregability. Only decreased collagen aggregation was recorded in the groups of first-degree mitral prolapse (MP) and first-degree MP + ALC; in second-degree MP and second-degree MP + ALC, there was a reduction in platelet aggregation on all inductors and an increase in TxB2. Patients with myxomatous degeneration of the mitral valve exhibited reduced collagen-induced platelet aggregation and lower plasma 6-keto-PGF1alpha levels.
  
  
  CONCLUSIONS
  The most pronounced changes in the thromboxane-prostacyclin balance and platelet aggregability were found in patients with MP and second-degree regurgitation, three intracardiac micro-abnormalities, and myxomatous degeneration of the mitral valve.
authors.forename: A V
authors.initials: AV
authors.lastname: Iagoda
authors.forename: N N
authors.initials: NN
authors.lastname: Gladkikh
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D016022:Case-Control Studies; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D012720:Severity of Illness Index; D013929:Thromboxane B2 / Q000097:blood*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine