title: A generic ionic model of cardiac action potentials.
abstract: A generic cardiac ionic model employing membrane currents based on two-gate Hodgkin-Huxley kinetics is presented. Its generic nature allows it to accurately reproduce action potential waveforms in heterogeneous cardiac tissue by optimizing parameters governing ion channel kinetics and magnitudes. The model allows a user-defined number of voltage and time-dependent ion currents to be incorporated, in order to reproduce and predict electrophysiological action potential waveforms from multiple recordings in individual cardiac myocytes.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, 2052, Australia.
authors.forename: Tianruo
authors.initials: T
authors.lastname: Guo
authors.forename: Amr Al
authors.initials: AA
authors.lastname: Abed
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
authors.forename: Socrates
authors.initials: S
authors.lastname: Dokos
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology*; D015640:Ion Channel Gating / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology*; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*; D011817:Rabbits