title: Periodontal disease is related to local and systemic mediators of inflammation.
abstract: BACKGROUND
  Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis. Fitzsimmons TR, Sanders AE, Bartold PM, Slade GD. J Clin Periodontol 2010;37(1):30-6.
  
  
  METHODS
  Ananda P. Dasanayake, BDS, MPH, PhD, FACE.
  
  
  OBJECTIVE
  The authors attempted to study the independent and combined effects of local (IL-1β) and systemic (CRP) inflammatory biomarkers in gingival crevicular fluid (GCF) on the risk of periodontitis.
  
  
  BACKGROUND
  Government: National Health and Medical Research Council (NHMRC) of Australia and NHMRC Sidney Sax Public Health Fellowship.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Level 2: Limited-quality, patient-oriented evidence.
  
  
  METHODS
  Not applicable.
authors.affiliation: Graduate Program in Clinical Research, New York University College of Dentistry, 250 Park Ave South, 6th Floor - Room 646, New York, NY 10003-1402, USA. ad75@nyu.edu
authors.forename: Ananda P
authors.initials: AP
authors.lastname: Dasanayake