title: [Are human papillomaviruses responsible for the occurrence of bladder cancer].
abstract: A female patient with recurrent bladder cancer underwent complex examination. The primary tumor removed in 2004 showed human papillomavirus (HPV) 16 DNA, mRNA corresponding to HPV16 oncogene E7, as well as HPV16 protein E7. The patient is a smoker who has been working at a chemical factory for over 20 years. During tumor recurrence in 2009, there was no DNA of high-risk HPV types in the cancer cells. HPV16 E7protein and cellular p 16(INK4alpha), an indicator of HPV-induced carcinogenesis, were not found. Colposcopy revealed no precancerous changes in the epithelium of the cervix uteri. The cervical epitheliocytes contained no high-risk HPV DNA, E7 and p16(INK4alpha) proteins. It seems expedient to continue in vitro studies of the possible role of HPV in urothelial carcinogenesis on an experimental model.
authors.forename: G M
authors.initials: GM
authors.lastname: Volgareva
authors.forename: L É
authors.initials: LÉ
authors.lastname: Zavalishina
authors.forename: O B
authors.initials: OB
authors.lastname: Trofimova
authors.forename: L I
authors.initials: LI
authors.lastname: Korolenkova
authors.forename: A V
authors.initials: AV
authors.lastname: Khachaturian
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Andreeva
authors.forename: V D
authors.initials: VD
authors.lastname: Ermilova
authors.forename: N L
authors.initials: NL
authors.lastname: Cheban
authors.forename: D A
authors.initials: DA
authors.lastname: Kuevda
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Shipulina
authors.forename: V A
authors.initials: VA
authors.lastname: Glazunova
authors.forename: D A
authors.initials: DA
authors.lastname: Golovina
authors.forename: A N
authors.initials: AN
authors.lastname: Petrov
authors.forename: V B
authors.initials: VB
authors.lastname: Matveev
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
mesh_terms: D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D005260:Female; D052162:Human papillomavirus 16; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000821:virology*; D050725:Papillomavirus E7 Proteins / Q000378:metabolism; D030361:Papillomavirus Infections / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000821:virology*; D012333:RNA, Messenger / Q000378:metabolism; D014412:Tumor Virus Infections / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000821:virology*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000821:virology*
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D050725:Papillomavirus E7 Proteins; D012333:RNA, Messenger; C059731:oncogene protein E7, Human papillomavirus type 16