title: Three-dimensional structures of OSW-1 and its congener.
abstract: The 3D structures of an antitumor glycosylsterol OSW-1 and its closely related congener were investigated by NMR studies and an X-ray crystallographic analysis. The disaccharide moiety was found as a structural scaffold for the formation of a hydrophobic cluster by the biologically required functionalities.
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, 184-8588, Japan. sakuraik@cc.tuat.ac.jp
authors.forename: Kaori
authors.initials: K
authors.lastname: Sakurai
authors.forename: Takuro
authors.initials: T
authors.lastname: Fukumoto
authors.forename: Keiichi
authors.initials: K
authors.lastname: Noguchi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Asaka
authors.forename: Naomi
authors.initials: N
authors.lastname: Moriyama
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yohda
mesh_terms: D002783:Cholestenones / Q000737:chemistry*; D018360:Crystallography, X-Ray; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry*
chemical_list: D002783:Cholestenones; D012503:Saponins; C106408:OSW 1