title: Disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules via covalent layer-by-layer assembly.
abstract: The disintegration-controllable stimuli-responsive polyelectrolyte multilayer microcapsules have been fabricated via the covalent layer-by-layer assembly between the amino groups of chitosan (CS) and the aldehyde groups of the oxidized sodium alginate (OSA) onto the sacrificial templates (polystyrene sulfonate, PSS) which was removed by dialysis subsequently. The covalent crosslinking bonds of the multilayer microcapsules were confirmed by FTIR analysis. The TEM analysis showed that the diameter of the multilayer microcapsules was <200nm. The diameter of the multilayer microcapsules decreased with the increasing of the pH values or the ionic strength. The pH and ionic strength dual-responsive multilayer microcapsules were stable in acidic and neutral media while they could disintegrate only at strong basic media.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Mu
authors.forename: Chunyin
authors.initials: C
authors.lastname: Lu
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
mesh_terms: D002214:Capsules; D004064:Digestive System / Q000473:pathology; D004337:Drug Carriers; D004573:Electrolytes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007477:Ions; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008863:Microspheres; D011137:Polystyrenes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013997:Time Factors
chemical_list: D002214:Capsules; D004337:Drug Carriers; D004573:Electrolytes; D007477:Ions; D011137:Polystyrenes; C003321:polystyrene sulfonic acid