title: Brain herniation in a neonate.
abstract: Brain herniation is generally thought to be unlikely to occur in newborns due to the presence of the patent fontanelles and cranial sutures. A review of the literature published from 1993 to 2008 via MEDLINE search revealed no reports on neonatal brain herniation from intracranial tumour. We report a preterm Malay male infant born via elective Caesarean section for antenatally diagnosed intracerebral tumour, which subsequently developed herniation. Cerebral magnetic resonance imaging showed features that were compatible with a large complex intracranial tumour causing mass effect and gross hydrocephalus. Tumour excision was scheduled when the infant was two weeks old. Unfortunately, on the morning of the surgery, he developed signs of brain herniation and had profuse tumour haemorrhage during the attempted excision. Histopathological examination revealed an embryonal tumour, possibly an atypical rhabdoid/teratoid tumour. This case illustrates that intracranial tumours in newborns can herniate and should therefore be closely monitored.
authors.affiliation: Department of Paediatrics, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia. cheeyeng@gmail.com
authors.forename: C Y
authors.initials: CY
authors.lastname: Wong
authors.forename: A B
authors.initials: AB
authors.lastname: Azizi
authors.forename: I
authors.initials: I
authors.lastname: Shareena
authors.forename: J
authors.initials: J
authors.lastname: Rohana
authors.forename: N Y
authors.initials: NY
authors.lastname: Boo
authors.forename: M R
authors.initials: MR
authors.lastname: Isa
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology; D055762:Cranial Fontanelles / Q000033:anatomy & histology; D005260:Female; D006547:Hernia / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology; D011859:Radiography; D018335:Rhabdoid Tumor / Q000473:pathology; D012886:Skull / Q000473:pathology; D013724:Teratoma / Q000473:pathology