title: Integration of brassinosteroid signal transduction with the transcription network for plant growth regulation in Arabidopsis.
abstract: Brassinosteroids (BRs) regulate a wide range of developmental and physiological processes in plants through a receptor-kinase signaling pathway that controls the BZR transcription factors. Here, we use transcript profiling and chromatin-immunoprecipitation microarray (ChIP-chip) experiments to identify 953 BR-regulated BZR1 target (BRBT) genes. Functional studies of selected BRBTs further demonstrate roles in BR promotion of cell elongation. The BRBT genes reveal numerous molecular links between the BR-signaling pathway and downstream components involved in developmental and physiological processes. Furthermore, the results reveal extensive crosstalk between BR and other hormonal and light-signaling pathways at multiple levels. For example, BZR1 not only controls the expression of many signaling components of other hormonal and light pathways but also coregulates common target genes with light-signaling transcription factors. Our results provide a genomic map of steroid hormone actions in plants that reveals a regulatory network that integrates hormonal and light-signaling pathways for plant growth regulation.
authors.affiliation: Department of Plant Biology, Carnegie Institution for Science, Stanford, CA 94305, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Xi-Ying
authors.initials: XY
authors.lastname: Fan
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Cao
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Tang
authors.forename: Kun
authors.initials: K
authors.lastname: He
authors.forename: Jia-Ying
authors.initials: JY
authors.lastname: Zhu
authors.forename: Jun-Xian
authors.initials: JX
authors.lastname: He
authors.forename: Ming-Yi
authors.initials: MY
authors.lastname: Bai
authors.forename: Shengwei
authors.initials: S
authors.lastname: Zhu
authors.forename: Eunkyoo
authors.initials: E
authors.lastname: Oh
authors.forename: Sunita
authors.initials: S
authors.lastname: Patil
authors.forename: Tae-Wuk
authors.initials: TW
authors.lastname: Kim
authors.forename: Hongkai
authors.initials: H
authors.lastname: Ji
authors.forename: Wing Hong
authors.initials: WH
authors.lastname: Wong
authors.forename: Seung Y
authors.initials: SY
authors.lastname: Rhee
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D017360:Arabidopsis / Q000166:cytology / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D001665:Binding Sites; D047369:Chromatin Immunoprecipitation; D004268:DNA-Binding Proteins; D018506:Gene Expression Regulation, Plant; D053263:Gene Regulatory Networks; D018745:Genome, Plant; D008027:Light; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D010937:Plant Growth Regulators / Q000235:genetics / Q000378:metabolism*; D030821:Plants, Genetically Modified; D015398:Signal Transduction / Q000502:physiology*; D013256:Steroids / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; C454444:BZR1 protein, Arabidopsis; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D010937:Plant Growth Regulators; D013256:Steroids; D014157:Transcription Factors