title: Pancreatic lipase inhibition by C-glycosidic flavones Isolated from Eremochloa ophiuroides.
abstract: Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-ß-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC₅₀ values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.
authors.affiliation: Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Institute (KAERI), Jeongeup 580-185, Korea.
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Lee
authors.forename: Seung Sik
authors.initials: SS
authors.lastname: Lee
authors.forename: Byung Yeoup
authors.initials: BY
authors.lastname: Chung
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Cho
authors.forename: In Chul
authors.initials: IC
authors.lastname: Lee
authors.forename: So Ra
authors.initials: SR
authors.lastname: Ahn
authors.forename: Soo Jeung
authors.initials: SJ
authors.lastname: Jang
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D006109:Poaceae / Q000737:chemistry*; D013552:Swine
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D008049:Lipase