title: Helicobacter pylori chromosomal DNA replication: current status and future perspectives.
abstract: Helicobacter pylori causes gastritis, gastric ulcer and gastric cancer. Though DNA replication and its control are central to bacterial proliferation, pathogenesis, virulence and/or dormancy, our knowledge of DNA synthesis in slow growing pathogenic bacteria like H. pylori is still preliminary. Here, we review the current understanding of DNA replication, replication restart and recombinational repair in H. pylori. Several differences have been identified between the H. pylori and Escherichia coli replication machineries including the absence of DnaC, the helicase loader usually conserved in gram-negative bacteria. These differences suggest different mechanisms of DNA replication at initiation and restart of stalled forks in H. pylori.
authors.affiliation: Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
authors.forename: Ram Gopal
authors.initials: RG
authors.lastname: Nitharwal
authors.forename: Vijay
authors.initials: V
authors.lastname: Verma
authors.forename: Santanu
authors.initials: S
authors.lastname: Dasgupta
authors.forename: Suman Kumar
authors.initials: SK
authors.lastname: Dhar
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002876:Chromosomes, Bacterial / Q000235:genetics*; D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics; D016480:Helicobacter pylori / Q000235:genetics* / Q000378:metabolism; D008957:Models, Genetic; D011995:Recombination, Genetic; D018741:Replication Origin
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial