title: [Identification of exotoxin-specific motifs/domains in bacterial exotoxin sequences and corresponding gene ontology analysis].
abstract: OBJECTIVE
  To identify the exotoxin-specific motifs/domains in bacterial exotoxin sequences, and to expand understanding of bacterial exotoxins pathogenic mechanisms.
  
  
  METHODS
  We constructed a non-pathogenic bacterial proteins database and collected 89 bacterial exotoxin sequences from Virulence factor database (VFDB), then we analyzed these protein sequences by motif/domain search using InterProScan (www.ebi.ac.uk/Tools/InterProScan/).
  
  
  RESULTS
  We identified 39 exotoxin-specific motifs/domains in 89 bacterial exotoxin sequences.
  
  
  CONCLUSIONS
  The identified exotoxin-specific motifs/domains were closely related to the functions of the exotoxins and could be used as template to search for new exotoxins by mining pathogenic bacterial genomes. The analysis of the acquired Gene Ontology (GO) items was to further expend our understanding of bacterial exotoxin pathogenic mechanisms.
authors.affiliation: Institute of Hygiene and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China. niuchao601@126.com
authors.forename: Chao
authors.initials: C
authors.lastname: Niu
authors.forename: Yuelan
authors.initials: Y
authors.lastname: Wang
authors.forename: Junjie
authors.initials: J
authors.lastname: Yue
authors.forename: Bao'an
authors.initials: B
authors.lastname: Ning
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Gao
authors.forename: Long
authors.initials: L
authors.lastname: Liang
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D030562:Databases, Protein; D005098:Exotoxins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D005098:Exotoxins