title: A rare cardiac neoplasm: case report of cardiac epithelioid angiosarcoma.
abstract: Primary cardiac angiosarcoma is a rare neoplasm and the epithelioid variant is exceedingly rare. We report a case of an epithelioid angiosarcoma that involved the right atrium and aorta of a 47-year-old male. The patient presented with atrial fibrillation and presyncopal spells. Following clinical evaluation, including computed tomography scan and trans-esophageal echocardiography, the neoplasm was surgically removed. It was a poorly differentiated malignant neoplasm composed of medium-sized epithelioid cells with a moderate amount of amphophilic cytoplasm. Immunohistochemical staining, including positive staining for CK22, AE1/AE3, melan-A, vimentin, and CD31, indicated the neoplasm was best categorized as an epithelioid angiosarcoma.
authors.affiliation: Heart and Lung Insitute, James Hogg Research Centre Biobank, Vancouver, BC, Canada. lise.matzke@hli.ubc.ca
authors.forename: Lise Anne Marie
authors.initials: LA
authors.lastname: Matzke
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Knowling
authors.forename: Dennis
authors.initials: D
authors.lastname: Grant
authors.forename: James B
authors.initials: JB
authors.lastname: Cupples
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
authors.forename: Andrew
authors.initials: A
authors.lastname: Ignaszewski
authors.forename: Michael F
authors.initials: MF
authors.lastname: Allard
mesh_terms: D001012:Aorta, Abdominal / Q000473:pathology / Q000601:surgery; D001281:Atrial Fibrillation / Q000209:etiology / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D003131:Combined Modality Therapy; D017548:Echocardiography, Transesophageal; D015622:Epithelioid Cells / Q000378:metabolism / Q000473:pathology*; D017809:Fatal Outcome; D006325:Heart Atria / Q000473:pathology / Q000601:surgery; D006338:Heart Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006394:Hemangiosarcoma / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor