title: Enantioselective conjugate addition of oximes to trisubstituted β-nitroacrylates: an organocatalytic approach to β(2,2)-amino acid derivatives.
abstract: A highly enantioselective organocatalytic intermolecular conjugate addition of oximes to β-nitroacrylates has been developed. The highly functionalized adducts obtained are valuable precursors for asymmetric synthesis, as demonstrated by the synthesis of β(2,2)-amino acids and oxazolidin-2-ones.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Fu-Gen
authors.initials: FG
authors.lastname: Zhang
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Xuan
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Lu
authors.forename: Shu-Wen
authors.initials: SW
authors.lastname: Duan
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D017672:Nitrogen Compounds / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D000596:Amino Acids; D017672:Nitrogen Compounds; D010091:Oximes; C036658:acrylic acid