title: Crucial role of selenium in the virucidal activity of benzisoselenazol-3(2H)-ones and related diselenides.
abstract: Various N-substituted benzisoselenazol-3(2H)-ones and their non-selenium-containing analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogues having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogues of benzisoselenazol-3(2H)-ones--diselenides also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses.
authors.affiliation: Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland. magdalena.pietka@pwr.wroc.pl
authors.forename: Magdalena
authors.initials: M
authors.lastname: Pietka-Ottlik
authors.forename: Piotr
authors.initials: P
authors.lastname: Potaczek
authors.forename: Egbert
authors.initials: E
authors.lastname: Piasecki
authors.forename: Jacek
authors.initials: J
authors.lastname: Mlochowski
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001393:Azoles / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D054833:Isoindoles; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012643:Selenium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013457:Sulfur Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014780:Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; D013457:Sulfur Compounds; C042986:ebselen; D012643:Selenium