title: Application of molecular findings to the diagnosis and management of breast disease: recent advances and challenges.
abstract: Established criteria are used in the diagnosis and management of patients with breast cancer. Although there are indicators of long-term survival (eg, the Nottingham Prognostic Index), it is clear that patients with very similar tumors may have quite different clinical behaviors (eg, response to treatment or outcome). This variability is partly explained by the underlying molecular composition of a tumor, encompassing genomic, transcriptomic, and proteomic alterations. Our quest to define this molecular basis of breast cancer has driven the amazing development of high-throughput technologies seen in recent years and that are now revolutionizing cancer biology. It is clear that core molecular pathways that are dysregulated in cancer, including oncogenic signaling and the DNA-damage response, are intimately linked to tumor behavior and hence will make useful targets for therapy. The integration of these multiple layers of new knowledge will have a major impact in clinical oncology, leading to significant breakthroughs in diagnosis and treatment.
authors.affiliation: Molecular & Cellular Pathology, The University of Queensland, UQ Centre for Clinical Research, Herston, 4029 Brisbane, Australia. p.simpson@uq.edu.au
authors.forename: Peter T
authors.initials: PT
authors.lastname: Simpson
authors.forename: Ana-Cristina
authors.initials: AC
authors.lastname: Vargas
authors.forename: Fares
authors.initials: F
authors.lastname: Al-Ejeh
authors.forename: Kum Kum
authors.initials: KK
authors.lastname: Khanna
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
authors.forename: Sunil R
authors.initials: SR
authors.lastname: Lakhani
mesh_terms: D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D004249:DNA Damage; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D057089:Pathology, Molecular / Q000379:methods; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor