title: Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids.
abstract: First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, C34:5n5.d(2), and three other unlabeled very long chain C30-32-containing polyunsaturated fatty acids are reported here. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation.
authors.affiliation: Chemical Synthesis Core Facility, Mayo Clinic Jacksonville, FL 32246, USA.
authors.forename: Ghulam M
authors.initials: GM
authors.lastname: Maharvi
authors.forename: Albert O
authors.initials: AO
authors.lastname: Edwards
authors.forename: Abdul H
authors.initials: AH
authors.lastname: Fauq