title: Infection in total hip replacement: meta-analysis.
abstract: While total hip arthroplasty has progressed to become one of the most successful surgical procedures ever developed, infection remains a serious complication. We have conducted a review of the literature pertaining to management of deep infection in total hip arthroplasty, specifically focusing on clinically relevant articles published in the last five years. A search was conducted using MEDLINE and PubMed, as well as a review of the Cochrane database, using the terms "total hip arthroplasty", "total hip replacement" and "infection". References for all selected articles were cross-checked. While the so-called two-stage revision is generally considered to be the gold standard for management, numerous studies now report outcomes for implant retention and reassessing one-stage revision strategies. There are encouraging reports for complex reconstruction options in patients with associated severe bone stock loss. The duration of antibiotic therapy remains controversial. There is concern about increasing bacterial resistance especially with the widespread use of vancomycin and ertapenem (carbapenem).
authors.affiliation: Department of Orthopaedic Surgery, Middlemore Hospital, South Auckland Clinical School, University of Auckland, Private Bag, 93311, Auckland, New Zealand.
authors.forename: Surendra
authors.initials: S
authors.lastname: Senthi
authors.forename: Jacob T
authors.initials: JT
authors.lastname: Munro
authors.forename: Rocco P
authors.initials: RP
authors.lastname: Pitto
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000379:methods; D001424:Bacterial Infections / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D016206:Databases, Bibliographic; D003646:Debridement; D006621:Hip Joint / Q000382:microbiology / Q000601:surgery; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D016459:Prosthesis-Related Infections / Q000209:etiology* / Q000382:microbiology / Q000628:therapy; D012086:Reoperation; D013530:Surgical Wound Infection / Q000209:etiology* / Q000382:microbiology / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents