title: Aspergillus as a multi-purpose cell factory: current status and perspectives.
abstract: Aspergilli have a long history in biotechnology as expression platforms for the production of food ingredients, pharmaceuticals and enzymes. The achievements made during the last years, however, have the potential to revolutionize Aspergillus biotechnology and to assure Aspergillus a dominant place among microbial cell factories. This mini-review will highlight most recent breakthroughs in fundamental and applied Aspergillus research with a focus on new molecular tools, techniques and products. New trends and concepts related to Aspergillus genomics and systems biology will be discussed as well as the challenges that have to be met to integrate omics data with metabolic engineering attempts.
authors.affiliation: Department of Molecular Microbiology and Biotechnology, Leiden University, Institute of Biology Leiden, Sylviusweg 72, 2333 BE, Leiden, The Netherlands. v.meyer@biology.leidenuniv.nl
authors.forename: Vera
authors.initials: V
authors.lastname: Meyer
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Arthur F J
authors.initials: AF
authors.lastname: Ram
mesh_terms: D001230:Aspergillus / Q000235:genetics* / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D005818:Genetic Engineering / Q000379:methods*; D023281:Genomics / Q000379:methods; D049490:Systems Biology / Q000379:methods*