title: [Advances in the study of nisin resistance--a review].
abstract: Nisin, a lantibiotic produced by some species of Lactococcus lactis, has broad antibacterial spectrum against Gram-positive bacteria species, especially those with close phylogenetic relationship to the nisin producing strain. The broad use of nisin did not lead to widespread resistance. However, some non-nisin producing bacteria could develop certain mechanisms of resistance against nisin when growing under laboratory or nature selection pressure. Nisin resistance mainly involved two strategies, namely, the non-specific physiological isolation mechanism (by the change of cell wall or membrane structure and composition) and the specific protease-mediated mechanism. This review introduced the advances in the study of nisin resistance mechanism.
authors.affiliation: College of Life Sciences, Capital Normal University, Beijing 100048, China. anchercxd@163.com
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chu
authors.forename: Yuheng
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhizeng
authors.initials: Z
authors.lastname: Sun
authors.forename: Liandong
authors.initials: L
authors.lastname: Huan
authors.forename: Jin
authors.initials: J
authors.lastname: Zhong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D024881:Drug Resistance, Bacterial / Q000502:physiology; D009561:Nisin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009561:Nisin