title: A general and mild domino approach to substituted 1-aminoindoles.
abstract: A versatile and efficient palladium catalyzed domino reaction leading to a broad range of substituted 1-aminoindoles has been developed. The title compounds were prepared from 2-halo-phenylacetylenes and simple hydrazines in good to excellent yields in just a few hours under mild conditions.
authors.affiliation: Sanofi-Aventis Deutschland GmbH, Industriepark Höchst Building G875, D-65926 Frankfurt am Main, Germany. nis.halland@sanofi-aventis.com
authors.forename: Nis
authors.initials: N
authors.lastname: Halland
authors.forename: Marc
authors.initials: M
authors.lastname: Nazaré
authors.forename: Jorge
authors.initials: J
authors.lastname: Alonso
authors.forename: Omar
authors.initials: O
authors.lastname: R'kyek
authors.forename: Andreas
authors.initials: A
authors.lastname: Lindenschmidt
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000588:Amines; D007211:Indoles; D010165:Palladium