title: [Comparison of single intubating dose and continuous infusion of rocuronium in prolonged gynecologic laparoscopic surgery].
abstract: OBJECTIVE
  To compare the cardiorespiratory factors and surgical conditions during total intravenous anesthesia for prolonged laparoscopic pelvic surgery with or without supplemental muscle relaxants.
  
  
  METHODS
  Forty female ASA I or II patients undergoing laparoscopic pelvic surgeries were randomized into two groups A and B, both with standardized anesthesia via a intravenous bolus injection of rocuronium (0.6 mg/kg). The patients in group B received continuous rocuronium infusion upon observation of one TOF twitch response with the T1 value maintained within 0-10% and rocuronium withdrawal at 20 to 30 min before the completion of the surgery. The patients in group A received no supplemental muscle relaxants. The cardiorespiratory parameters were measured during the operation. The respiratory system compliance (Ceff rs) was calculated as the quotient of the tidal volume (VT) and peak inspiratory pressure (PIP), and the operative conditions were graded by the operating gynecologist.
  
  
  RESULTS
  The cardiorespiratory parameters significant increased and Ceff rs decreased after pneumoperitoneum, but no significant differences were found between the two groups. The surgical conditions were also comparable between the two groups, but the duration of intubation and the operating time were significantly shorter in the group A.
  
  
  CONCLUSIONS
  Pneumoperitoneum severely affects the cardiorespiratory parameters during laparoscopy, which can not be lessened by neuromuscular block agents. A single intubating dose of rocuronium can suffice the requirement of prolonged gynecologic laparoscopic surgery.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
authors.forename: Ming-fang
authors.initials: MF
authors.lastname: Xiang
authors.forename: Dong-hua
authors.initials: DH
authors.lastname: Hu
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Liao
authors.forename: Yan-nian
authors.initials: YN
authors.lastname: Yan
authors.forename: Ya-lan
authors.initials: YL
authors.lastname: Li
mesh_terms: D000732:Androstanols / Q000008:administration & dosage*; D000771:Anesthesia, Intravenous; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D000077123:Rocuronium
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium