title: Potential antimalarials from Nigerian plants: a review.
abstract: Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious diseases in many tropical regions, including Nigeria, a West African country where transmission occurs all year round. Many of the inhabitants use plants as remedies against fever and other symptoms of acute malaria, as reported herein. Some of these plants have their antimalarial efficacies scientifically demonstrated and the active compounds isolated with their probable mechanisms of action studied. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. This review focuses on medicinal plants which are used to treat malaria in Nigeria, and on antimalarial testing of extracts and purified compounds from plants. Some show intense activity against malaria parasites in vitro and in experimentally infected mice. The search for new drugs based on plants is important due to the emergence and widespread of chloroquine-resistant and multiple drug-resistant malaria parasites, which require the development of new antimalarials. An acquaintance with antimalarial plants may be a springboard for new phytotherapies that could be affordable to treat malaria, especially among the less privileged native people living in endemic areas of the tropics, mostly at risk of this devastating disease.
authors.affiliation: Laboratorio de Malaria, Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte MG, Brazil. topebayo2002@yahoo.com
authors.forename: J O
authors.initials: JO
authors.lastname: Adebayo
authors.forename: A U
authors.initials: AU
authors.lastname: Krettli
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D020834:Ethnopharmacology; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000188:drug therapy; D016488:Medicine, African Traditional; D051379:Mice; D009549:Nigeria; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010961:Plasmodium / Q000187:drug effects
chemical_list: D000962:Antimalarials; D010936:Plant Extracts