title: Efficacy and safety of ethanol ablation for thyroglossal duct cysts.
abstract: OBJECTIVE
  TGDC is a common congenital neck lesion, which has been treated by surgery. Although surgery is curative, it has drawbacks such as scars and surgical morbidity. Therefore, we applied EA as an alternative treatment technique. The purpose of this study was the evaluation of the efficacy and safety of EA for TGDC.
  
  
  METHODS
  Between May 2005 and July 2008, we performed EA in 11 patients with TGDC who refused surgery. All patients were confirmed as having benign lesions before treatment. US-guided aspiration of the cystic fluid was followed by injection of absolute ethanol (99%). The injected volume of ethanol was 50%-80% of the volume of fluid aspirated. We evaluated the therapeutic outcome, including volume reduction of the TGDC, improvement of cosmetic problems and symptoms, and complications.
  
  
  RESULTS
  The initial volume of the cysts ranged from 0.67 to 29.39 mL (mean, 6.0 mL). The procedure was performed in 1-3 sessions (mean, 1.4 sessions). Follow-up US was performed in 10 patients from 3 to 29 months (mean, 13.6 months). The mean volume of the cyst was 6.0 ± 8.4 mL, and volume reduction was 43.9%-100% (mean, 81.3%, P = .005) at last follow-up. Therapeutic success (volume reduction of >50%) was observed in 8 patients (8/10, 80%). Significant improvement of symptom- (P = .005) and cosmetic-grading scores (P = .003) was observed at last follow-up. No significant complications were observed during the procedure or follow-up periods.
  
  
  CONCLUSIONS
  EA seems to be an effective and safe treatment method for TGDC.
authors.affiliation: Department of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: S M
authors.initials: SM
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Baek
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: J Y
authors.initials: JY
authors.lastname: Sung
authors.forename: H K
authors.initials: HK
authors.lastname: Lim
authors.forename: H
authors.initials: H
authors.lastname: Choi
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000328:Adult; D017115:Catheter Ablation; D003357:Cosmetic Techniques; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D036502:Infusions, Intralesional; D008297:Male; D012997:Solvents / Q000008:administration & dosage* / Q000009:adverse effects; D013955:Thyroglossal Cyst / Q000000981:diagnostic imaging / Q000601:surgery* / Q000628:therapy*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D012997:Solvents; D000431:Ethanol