title: Association of the change in serum estradiol (E2) levels from the day of to the day after human chorionic gonadotropin (hCG) injection and pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET) in less than average responders.
abstract: OBJECTIVE
  To determine if the change in serum estradiol (E2) from the day of human chorionic gonadotropin (hCG) injection to the day after predicts pregnancy and implantation rates following in vitro fertilization-embryo transfer (IVF-ET) in less than average responders.
  
  
  METHODS
  A retrospective cohort analysis was performed in women with less than average follicular response as defined by a peak serum E2 on the day of hCG of < 1500 pg/ml despite a maximum stimulation gonadotropin protocol. Pregnancy and implantation rates were compared in five groups based on standard deviation (SD) below or above the mean.
  
  
  RESULTS
  No differences were found in outcome in any groups including those that were 1-2 SD below the mean or within 1 SD below the mean or up to 2 SD above the mean. The group that was 2 SD above the mean seemingly had higher pregnancy and implantation rates but there were insufficient numbers to allow statistical comparisons. There did not appear to be any confounding variables among these groups.
  
  
  CONCLUSIONS
  A drop in serum E2 in a group of women that were less than average responders was not associated with a lower chance of conception following IVF-ET.
authors.affiliation: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: J K
authors.initials: JK
authors.lastname: Choe
authors.forename: J
authors.initials: J
authors.lastname: Amui
authors.forename: D
authors.initials: D
authors.lastname: Brasile
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood; D011247:Pregnancy; D011256:Pregnancy Outcome; D012102:Reproductive Control Agents / Q000008:administration & dosage*; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D012102:Reproductive Control Agents; D004958:Estradiol