title: [Exploration of metastasis-related proteins based upon proteomic analysis].
abstract: Omics analysis is defined as a comprehensive analysis of various biological aspects from gene sequence to metabolite pattern via protein expression, and it might revolutionarily alter the design of scientific experiments as well as the process of biological investigation. Furthermore, omics technologies allow the generation of huge amounts of data at high-throughput. Particularly, proteomics is one of the omics technologies, which is a comprehensive analysis of protein, and it is hoped that proteomics accelerates translational research in the field of malignant neoplasm. Given the present status of proteomics technologies, we performed differential analysis between two categories such as a metastasis-positive group and a negative group using the clinical materials of a single kind of malignant neoplasm, and detected various kinds of protein molecules associated with metastasis. However, we could not obtain any evidence that these molecules were directly related with metastasis. The close relationship between clinical doctors, molecular pathologists and technical experts concerning proteomics is essential, because an experimental design, which they would generate, is extremely important for the detection of the targeted molecules. Additionally, in this paper some recent reports concerning the exploration of metastasis-related molecules using proteomic technology proteomics are introduced.
authors.affiliation: Toda Chuo General Hospital, Saitama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirano
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D006801:Humans; D008565:Membrane Proteins; D009362:Neoplasm Metastasis; D040901:Proteomics; D016601:RNA-Binding Proteins
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins