title: Down-modulation of Ca2+ channels by endogenously released ATP and opioids: from the isolated chromaffin cell to the slice of adrenal medullae.
abstract: Modifications in Ca(2+) influx may lead to profound changes in the cell activity associated with Ca(2+)-dependent processes, from muscle contraction and neurotransmitter release to calcium-mediated cell death. Therefore, calcium entry into the cell requires fine regulation. In this context, understanding of the modulation of voltage-dependent Ca(2+) channels seems to be critical. The modulatory process results in the enhancement or decrement of calcium influx that may regulate the local and global cytosolic Ca(2+) concentrations. Here, we summarize the well-established data on this matter described in isolated chromaffin cells by our laboratory and others, and the new results we have obtained in a more physiological preparation: freshly isolated slices of mouse adrenal medullae.
authors.affiliation: Departamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF 04510, México.
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: P
authors.initials: P
authors.lastname: Segura-Chama
authors.forename: E
authors.initials: E
authors.lastname: Albiñana
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Cruz
authors.forename: J M
authors.initials: JM
authors.lastname: Hernández-Guijo
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000313:Adrenal Medulla / Q000378:metabolism*; D000701:Analgesics, Opioid / Q000378:metabolism*; D000818:Animals; D019898:Autocrine Communication; D015220:Calcium Channels / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D002469:Cell Separation; D019439:Chromaffin Cells / Q000166:cytology* / Q000378:metabolism; D015536:Down-Regulation; D019204:GTP-Binding Proteins / Q000378:metabolism; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism; D019899:Paracrine Communication; D012146:Rest
chemical_list: D000701:Analgesics, Opioid; D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D018377:Neurotransmitter Agents; D000255:Adenosine Triphosphate; D019204:GTP-Binding Proteins