title: TRPM2 and pancreatic β-cell responses to oxidative stress.
abstract: Recent reports have linked the adenine nucleotide 2nd messenger gated Ca (2+) channel TRPM2 with hydrogen peroxide-induced pancreatic β-cell death in mouse and rat systems. As β-cells are exposed in vivo to reactive oxygen species produced via the respiratory chain and NADPH oxidases (reviewed in (3, 4) ), these reports suggest the existence of a TRPM2-dependent signaling pathway involved in β-cell responses to redox stress.
authors.affiliation: University of Washington School of Medicine Seattle Children's Research Institute, Seattle, WA 98103, USA. andrewms@u.washington.edu
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Scharenberg
mesh_terms: D000818:Animals; D050417:Insulin-Secreting Cells / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000235:genetics* / Q000502:physiology; D051381:Rats; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013312:Stress, Physiological / Q000235:genetics / Q000502:physiology; D050053:TRPM Cation Channels / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D050053:TRPM Cation Channels; C544443:TRPM2 protein, mouse