title: A new regimen of bowel preparation for PillCam colon capsule endoscopy: a pilot study.
abstract: BACKGROUND
  Colon capsule endoscopy (CCE) represents a new diagnostic, endoscopic technology for colonic exploration. Current protocols of preparation led to discordant rates of adequate cleansing level or CCE excretion.
  
  
  OBJECTIVE
  To evaluate the effect of a new regimen of bowel preparation for CCE on colon cleansing levels and on rate of capsule excretion.
  
  
  METHODS
  60 patients were prospectively enrolled. The new regimen of preparation consisted of a split regimen of PEG administration and of a 45 mL dose of sodium phosphate (NaP). Four senna tablets and a low-residue diet were also included. CCE excretion rate, colon cleansing, and accuracy were assessed.
  
  
  RESULTS
  Forty-six patients were included in the final analysis, 13 patients (22%) being excluded because of preparation protocol deviations and one due to CCE technical failure (2%). At CCE, bowel preparation was rated as good in 78% of patients, fair in 20% and poor in 2%. CCE excretion rate occurred in 83% of patients. CCE sensitivity and specificity for significant findings was 100% and 95%, respectively.
  
  
  CONCLUSIONS
  The combination of a split-dose of PEG solution with a low dose of NaP boosters resulted in high rates of adequate cleansing level and CCE excretion.
authors.affiliation: Digestive Endoscopy Unit, Catholic University, Largo Francesco Vito 1, Rome, Italy. cristianospada@gmail.com
authors.forename: Cristiano
authors.initials: C
authors.lastname: Spada
authors.forename: Cesare
authors.initials: C
authors.lastname: Hassan
authors.forename: Marcello
authors.initials: M
authors.lastname: Ingrosso
authors.forename: Alessandro
authors.initials: A
authors.lastname: Repici
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Riccioni
authors.forename: Marco
authors.initials: M
authors.lastname: Pennazio
authors.forename: Giuseppe Alessandro
authors.initials: GA
authors.lastname: Pirozzi
authors.forename: Nico
authors.initials: N
authors.lastname: Pagano
authors.forename: Paola
authors.initials: P
authors.lastname: Cesaro
authors.forename: Gianluca
authors.initials: G
authors.lastname: Spera
authors.forename: Lucio
authors.initials: L
authors.lastname: Petruzziello
authors.forename: Guido
authors.initials: G
authors.lastname: Costamagna
mesh_terms: D000328:Adult; D000368:Aged; D053705:Capsule Endoscopes; D053704:Capsule Endoscopy / Q000379:methods*; D002400:Cathartics / Q000008:administration & dosage*; D003111:Colonic Polyps / Q000175:diagnosis; D004043:Dietary Fiber; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000008:administration & dosage*; D010865:Pilot Projects; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011446:Prospective Studies; D012676:Senna Extract / Q000008:administration & dosage*
chemical_list: D002400:Cathartics; D004043:Dietary Fiber; D010710:Phosphates; D011092:Polyethylene Glycols; D012676:Senna Extract; C018279:sodium phosphate