title: Association of vascular endothelial growth factor -2578C/A gene polymorphism in Chinese patients with colon cancer.
abstract: The vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in the process of angiogenesis, a crucial phase in tumor growth and metastasis. We carried out a case-control study to evaluate whether VEGF -2578C/A gene polymorphism modulates the risk of developing colon cancer. A total of 110 colon cancer patients and 110 cancer-free healthy people were recruited in the Chinese population. Genomic DNA was isolated from peripheral blood, and gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Colon cancer patients had a significantly higher frequency of VEGF -2578AA genotype (odds ratio=2.49; 95% confidence interval=1.04, 6.01; p=0.04) than controls. Patients with left colon cancer had a significantly higher frequency of VEGF -2578AA genotype (odds ratio=2.31; 95% confidence interval=1.03, 5.18; p=0.04) than those with right colon cancer. When stratified by tumor size, growth pattern, differentiation, and stage of colon cancer, no statistically significant results were observed. This study suggested that VEGF -2578AA genotype was associated with a higher risk of colon cancer in Chinese population. Further studies are needed to understand the mechanism of VEGF gene polymorphisms in the development and progression of colon cancer.
authors.affiliation: Center of General Surgery, Chengdu General Hospital of Chengdu Military Area Command, Chengdu, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Guohu
authors.initials: G
authors.lastname: Zhang
authors.forename: Peihong
authors.initials: P
authors.lastname: Wang
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Gong
authors.forename: Yongkuan
authors.initials: Y
authors.lastname: Cao
authors.forename: Lijun
authors.initials: L
authors.lastname: Tang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A