title: Management of punding in Parkinson's disease: an open-label prospective study.
abstract: Punding, a peculiar stereotyped behavior characterized by intense fascination with complex, excessive, non-goal-oriented, repetitive activities, is a quite rare condition complicating Parkinson's disease (PD). It is triggered by dopaminergic therapy and could have a strong impact on patient quality of life. No study has specifically investigated medical management of this condition, and only a few anecdotal reports have provided therapeutic hints. Given the suggested similarities to drug-induced dyskinesias, we have previously suggested a multistep algorithm for management of punding. We conducted a prospective open-label study on ten PD punders aimed at testing its validity. In two cases, reduction of levodopa therapy was efficacious; amantadine was effective in controlling punding in four cases; in the remaining cases, quetiapine was employed, with mild efficacy in two cases.
authors.affiliation: Istituto di Neurologia, Università Cattolica del Sacro Cuore Largo Agostino Gemelli, 8, 00168 Rome, Italy. alfonso.fasano@rm.unicatt.it
authors.forename: A
authors.initials: A
authors.lastname: Fasano
authors.forename: L
authors.initials: L
authors.lastname: Ricciardi
authors.forename: M
authors.initials: M
authors.lastname: Pettorruso
authors.forename: A R
authors.initials: AR
authors.lastname: Bentivoglio
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D000547:Amantadine / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D011446:Prospective Studies; D000069348:Quetiapine Fumarate; D019956:Stereotypic Movement Disorder / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D007980:Levodopa; D000547:Amantadine