title: Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo.
abstract: We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPARδ-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPARδ is a viable drug candidate for targeting and treating atherosclerosis.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jungwook
authors.initials: J
authors.lastname: Chin
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Hong
authors.forename: Jaehwan
authors.initials: J
authors.lastname: Lee
authors.forename: Hoosang
authors.initials: H
authors.lastname: Hwang
authors.forename: Hyunsil
authors.initials: H
authors.lastname: Ko
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.forename: Dongyup
authors.initials: D
authors.lastname: Hahn
authors.forename: Jaeyoung
authors.initials: J
authors.lastname: Ko
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.forename: Jungae
authors.initials: J
authors.lastname: Tak
authors.forename: Jungyeob
authors.initials: J
authors.lastname: Ham
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000188:drug therapy; D031541:Fluorescence Resonance Energy Transfer; D008024:Ligands; D051379:Mice; D018345:Mice, Knockout; D047494:PPAR delta / Q000819:agonists* / Q000378:metabolism; D012643:Selenium / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry
chemical_list: D001057:Apolipoproteins E; D008024:Ligands; D047494:PPAR delta; D013844:Thiazoles; D012643:Selenium