title: Melanoma cells express ICOS ligand to promote the activation and expansion of T-regulatory cells.
abstract: CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion.
authors.affiliation: Department of Immunology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Natalia
authors.initials: N
authors.lastname: Martin-Orozco
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Li
authors.forename: Yijun
authors.initials: Y
authors.lastname: Wang
authors.forename: Shijuan
authors.initials: S
authors.lastname: Liu
authors.forename: Patrick
authors.initials: P
authors.lastname: Hwu
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
authors.forename: Laszlo
authors.initials: L
authors.lastname: Radvanyi
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018920:Coculture Techniques; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D060945:Inducible T-Cell Co-Stimulator Ligand; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D007739:L Cells; D008213:Lymphocyte Activation / Q000276:immunology; D008545:Melanoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008546:Melanoma, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D015703:Antigens, CD; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498514:ICOSLG protein, human; D060945:Inducible T-Cell Co-Stimulator Ligand; D053645:Interleukin-2 Receptor alpha Subunit; D016753:Interleukin-10; D007371:Interferon-gamma