title: [Results of clinical evaluation of a new screening method for determining the individual normal level of intraocular pressure].
abstract: The paper presents the results of practical application of a new screening method for determining tolerant intraocular pressure (TIOP) on a Blood Flow Analyzer (Paradigm, USA). Studies were conducted on 331 eyes (205 subjects). Group 1 consisted of 80 patients (126 eyes) without glaucoma being found, with intraocular pressure (IOP) in the average normal range, but with a TIOP excess of 1-8 mm Hg (a risk group); Group 2 included 15 subjects (20 eyes) without glaucoma with normal IOP in whom TIOP exceeded the existing IOP by 1-7 mm Hg; Group 3 comprised 110 patients (185 eyes) with Stage I-III primary open-angle glaucoma (POAG) with compensated IOP. Morphofunctional studies revealed glaucoma in 95 (75%) eyes in the risk group: Stages II and I in 61 and 30%, respectively; and advanced glaucoma in 9%. At the same time, there was a close correlation of the probable detection of glaucoma with the existing degree of a TIOP excess. No cases of glaucoma were observed in Group 2. The determination of TIOP and morphofunctional changes over time in Group 3 revealed a stable glaucomatous process in 99% of cases in which IOP was lower than or equal to TIOP, as well as progressive glaucomatous neuropathy in 91% in which compensated LOP exceeded TIOP. The results of the study in Group 3 suggest that the index TIOP may be used as a guide of IOP in the treatment and monitoring of POAG. The presented data indicate that the determination of the level of TIOP is a required element of both standard ophthalmological examination and monitoring of glaucoma.
authors.forename: S E
authors.initials: SE
authors.lastname: Avetisov
authors.forename: V R
authors.initials: VR
authors.lastname: Mamikonian
authors.forename: O A
authors.initials: OA
authors.lastname: Kazarian
authors.forename: O A
authors.initials: OA
authors.lastname: Shmeleva-Demir
authors.forename: N S
authors.initials: NS
authors.lastname: Galoian
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Mazurova
authors.forename: A A
authors.initials: AA
authors.lastname: Tatevosian
authors.forename: E G
authors.initials: EG
authors.lastname: Ryzhkova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005123:Eye / Q000098:blood supply; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008403:Mass Screening / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D012016:Reference Values; D012039:Regional Blood Flow; D014065:Tonometry, Ocular / Q000295:instrumentation / Q000379:methods*