title: MR and US imaging for breast cancer patients who underwent conservation surgery after neoadjuvant chemotherapy: comparison of triple negative breast cancer and other intrinsic subtypes.
abstract: BACKGROUND
  Neoadjuvant chemotherapy (NAC) is commonly utilized to treat operable breast cancer. The purpose of this study was to review the findings of ultrasonography (US) and magnetic resonance (MR) imaging in patients treated with breast conservation surgery (BCS) after NAC with a focus on intrinsic subtypes.
  
  
  METHODS
  Eighty-six patients underwent BCS after NAC. The tumors were classified into four subgroups by receptor status. US and MR were performed before and after NAC. The tumor diameters in US and MR after NAC were examined for correlations with pathological tumor distances in the specimens from BCS after NAC.
  
  
  RESULTS
  The correlation coefficient (r) of US to pathological tumor size was 0.3 in all tumors, 0.6 in HER2-type tumors, and 0.7 in triple negative breast cancers (TNBC). The correlation coefficient of tumor size in MR to pathological tumor size was 0.9 in TNBC, and other correlations were not statistically significant.
  
  
  CONCLUSIONS
  The correlation between tumor size in MR and pathological tumor size in triple negative breast cancers corresponded best. This information is one of the clues to selecting patients for BCS after NAC.
authors.affiliation: Breastopia Namba Hospital, Breastopia Medical Corporation, 2-112-1 Maruyama, Miyazaki, Miyazaki, 880-0052, Japan. nakahara@breastopia.org
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakahara
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Machida
authors.forename: Yorio
authors.initials: Y
authors.lastname: Maeda
authors.forename: Hidemi
authors.initials: H
authors.lastname: Furusawa
authors.forename: Kansei
authors.initials: K
authors.lastname: Komaki
authors.forename: Mayumi
authors.initials: M
authors.lastname: Funagayama
authors.forename: Mayumi
authors.initials: M
authors.lastname: Nakahara
authors.forename: Shozo
authors.initials: S
authors.lastname: Tamura
authors.forename: Futoshi
authors.initials: F
authors.lastname: Akiyama
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015412:Mastectomy, Segmental; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D016217:Ultrasonography, Mammary
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; C508053:ERBB2 protein, human