title: Perioperative statin use: an update.
abstract: HMG CoA reductase inhibitors (statins) are a proven modality to reduce serum cholesterol and have been shown to reduce morbidity and mortality in cardiovascular patients. Statins have also demonstrated improvements in postoperative outcomes among patients taking them in the perioperative period. Many of the studies are limited to select patient populations and/or select surgeries. This review will give an overview of the pharmacology of statins, summarize the mechanisms of the beneficial effects of statins, and provide an overview of evidence in the use of statins in the perioperative period.
authors.affiliation: Department of Anesthesiology, Tulane University Medical Center, 1430 Tulane Avenue, SL-4, New Orleans, LA 70112, USA.
authors.forename: Phillip L
authors.initials: PL
authors.lastname: Kalarickal
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Fox
authors.forename: Jeffrey Y
authors.initials: JY
authors.lastname: Tsai
authors.forename: Henry
authors.initials: H
authors.lastname: Liu
authors.forename: Alan D
authors.initials: AD
authors.lastname: Kaye
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D006348:Cardiac Surgical Procedures; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011300:Preoperative Care; D014656:Vascular Surgical Procedures; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors