title: Geographic variation in tissue accumulation of endocrine disrupting compounds (EDCs) in grazing sheep.
abstract: Muscle tissue was collected from ewes and lambs derived from farms throughout Scotland and sample concentrations of five endocrine disrupting compound groups were determined. Farms of origin were categorised according to geographic region. There were few statistically-significant differences with region or distance from cities. However, the magnitude of the difference between the highest and lowest mean values in ewe muscle from different regions exceeded 30% for 13 of the 15 compounds that were consistently detected in muscle, with animals derived from the industrialised region having the highest mean values for 11 of the 13 compounds. A less marked trend was apparent in the lamb muscle (8 of 13 highest were in the industrialised region). The physiological effects of such small differences in exposure to mixtures of pollutants remain to be determined.
authors.affiliation: Macaulay Land Use Research Institute, Craigiebuckler, Aberdeen AB15 8QH, UK. s.rhind@macaulay.ac.uk
authors.forename: S M
authors.initials: SM
authors.lastname: Rhind
authors.forename: C E
authors.initials: CE
authors.lastname: Kyle
authors.forename: C
authors.initials: C
authors.lastname: Mackie
authors.forename: K
authors.initials: K
authors.lastname: Yates
authors.forename: E I
authors.initials: EI
authors.lastname: Duff
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000032:analysis* / Q000378:metabolism*; D004785:Environmental Pollutants / Q000032:analysis* / Q000378:metabolism*; D005260:Female; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism*; D012606:Scotland; D012756:Sheep / Q000378:metabolism*
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants