title: The IgH 3' regulatory region and its implication in lymphomagenesis.
abstract: The 3' regulatory region (3'RR) located downstream of the IgH gene is the master element that controls class switch recombination and sustains high-level transcription at the plasma-cell stage. This latter role suggests that the 3'RR may be involved in oncogene deregulation during the frequent IgH translocation events associated with B-cell malignancies. A convincing demonstration of the essential contribution of 3'RR in lymphomagenesis has been provided by transgenic animal models. The mouse 3'RR shares a strong structural homology with the regulatory regions located downstream of each human Cα gene. Mouse models exploring the role of the 3'RR in B-cell physiology and in malignancies should provide useful indications about the pathophysiology of human cell lymphocyte proliferation.
authors.affiliation: Université de Limoges, Centre National de la Recherche Scientifique, CNRS UMR 6101, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Vincent-Fabert
authors.forename: Rémi
authors.initials: R
authors.lastname: Fiancette
authors.forename: Michel
authors.initials: M
authors.lastname: Cogné
authors.forename: Eric
authors.initials: E
authors.lastname: Pinaud
authors.forename: Yves
authors.initials: Y
authors.lastname: Denizot
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics* / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics* / Q000276:immunology
chemical_list: D020413:3' Untranslated Regions; D007143:Immunoglobulin Heavy Chains