title: New cytotoxic prostanoids from Taiwanese soft coral Clavularia viridis.
abstract: Chemical investigation of the AcOEt/MeOH extract of Clavularia viridis collected in Taiwan has afforded four new prostanoids, named claviridins A-D (1-4, resp.). The structures of compounds 1-4 were determined on the basis of 1D- and 2D-NMR techniques, including COSY, HMQC, HMBC, and NOESY experiments. Pharmacological studies revealed that compounds 1-4 exhibited potent cytotoxicity against human cancer cells.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road Sect. 1, Taipei, Taiwan, Republic of China. ycshen@ntu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Kuang-Liung
authors.initials: KL
authors.lastname: Lo
authors.forename: Jiun-Yang
authors.initials: JY
authors.lastname: Chang
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Khongorzul
authors.initials: K
authors.lastname: Mendbayar
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011453:Prostaglandins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013624:Taiwan
chemical_list: D011453:Prostaglandins