title: New insights into the biology and pathobiology of beta2-glycoprotein I.
abstract: β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms by which anti-β2GPI antibodies in complex with β2GPI may predispose an individual to the antiphospholipid syndrome clinical phenotype. This review examines some of the latest novel findings in this area.
authors.affiliation: Department of Immunology, Allergy, and Infectious Diseases, St. George Public Hospital, University of New South Wales, Sydney, Australia.
authors.forename: Bill
authors.initials: B
authors.lastname: Giannakopoulos
authors.forename: Peyman
authors.initials: P
authors.lastname: Mirarabshahi
authors.forename: Steven A
authors.initials: SA
authors.lastname: Krilis
mesh_terms: D016736:Antiphospholipid Syndrome / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D053482:beta 2-Glycoprotein I / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D053482:beta 2-Glycoprotein I