title: [Research on fibrinogen adsorption and its transformation response in hemocompatibility].
abstract: In this research,enzyme linked immunoassay (ELISA) was used to assay the fibrinogen (FIG) adsorbed on the Ti-O films and on the low temperature isotropic carbon (LTIC) films which were planted in the femoral arteries of 6 mongrel dogs for six months, respectively. The Ti-O films were planted in the dogs' left femoral arteries; the LTIC films as controls were planted in the dogs' right femoral arteries. The contents adsorbed in these two kinds of films were examined by scanning electron microscopy (SEM). The quantities of FIG adhered or denatured on the Ti-O films or LTIC films determined by ELISA, and the platelets adhered on the two kinds of films examined by SEM were of significant difference between the two groups. In the blood vessel, the amount of FIG adhered on biomaterial was related to its component and construction. FIG released electron to the biomaterial and induced the unfolding of C term of the gamma-chain of FIG, and the conjugation point and effect point were exposed. In conclusion, the biomaterial, which has the capability for resisting the electron release from FIG as well as for maintaining the invariable electric condition, will have excellent hemocompatibility.
authors.affiliation: Chengdu Railway Central Hospital, Chengdu 610081, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Jin
authors.forename: Guojiang
authors.initials: G
authors.lastname: Wan
authors.forename: Ansha
authors.initials: A
authors.lastname: Zhao
authors.forename: Yuechang
authors.initials: Y
authors.lastname: Lei
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Nan
authors.initials: N
authors.lastname: Huang
authors.forename: Xi
authors.initials: X
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Leng
authors.forename: Junying
authors.initials: J
authors.lastname: Chen
authors.forename: Mingyong
authors.initials: M
authors.lastname: Hou
mesh_terms: D000327:Adsorption; D000818:Animals; D004285:Dogs; D005340:Fibrinogen / Q000378:metabolism*; D006350:Heart Valve Prosthesis; D006648:Histocompatibility; D008968:Molecular Conformation; D010973:Platelet Adhesiveness; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D005340:Fibrinogen; D014025:Titanium