title: Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists.
abstract: Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct morphological features and clinical behaviors. Although morphology is often associated with the pattern of molecular aberrations in breast cancers, it is also clear that tumors of the same histological type show remarkably different clinical behavior. This is particularly true for 'basal-like cancer', which is an entity defined using gene expression analysis. The purpose of this article was to review the current state of knowledge of basal-like breast cancers, to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists.
authors.affiliation: Clarian Pathology Lab, Department of Pathology and Internal Medicine, Indiana University, Indianapolis, USA. sbadve@iupui.edu
authors.forename: Sunil
authors.initials: S
authors.lastname: Badve
authors.forename: David J
authors.initials: DJ
authors.lastname: Dabbs
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Schnitt
authors.forename: Frederick L
authors.initials: FL
authors.lastname: Baehner
authors.forename: Thomas
authors.initials: T
authors.lastname: Decker
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Eusebi
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Fox
authors.forename: Shu
authors.initials: S
authors.lastname: Ichihara
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Jacquemier
authors.forename: Sunil R
authors.initials: SR
authors.lastname: Lakhani
authors.forename: José
authors.initials: J
authors.lastname: Palacios
authors.forename: Emad A
authors.initials: EA
authors.lastname: Rakha
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Richardson
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Schmitt
authors.forename: Puay-Hoon
authors.initials: PH
authors.lastname: Tan
authors.forename: Gary M
authors.initials: GM
authors.lastname: Tse
authors.forename: Britta
authors.initials: B
authors.lastname: Weigelt
authors.forename: Ian O
authors.initials: IO
authors.lastname: Ellis
authors.forename: Jorge S
authors.initials: JS
authors.lastname: Reis-Filho
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018295:Neoplasms, Basal Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone