title: Steering deep brain stimulation fields using a high resolution electrode array.
abstract: Deep brain stimulation (DBS) therapy relies on electrical stimulation of neuronal elements in small brain targets. However, the lack of fine spatial control over field distributions in current systems implies that stimulation easily spreads into adjacent structures that may induce adverse side-effects. This study investigates DBS field steering using a novel DBS lead design carrying a high-resolution electrode array. We apply computational models to simulate voltage distributions and DBS activation volumes in order to theoretically assess the potential of field steering in DBS. Our computational analysis demonstrates that the DBS-array is capable of accurately displacing activation volumes with sub-millimeter precision. Our findings demonstrate that future systems for DBS therapy may provide for more accurate target coverage than currently available systems achieve.
authors.affiliation: Minimally Invasive Healthcare, Department, Philips Research, Eindhoven, The Netherlands. emiltoader@philipps.com
authors.forename: Emil
authors.initials: E
authors.lastname: Toader
authors.forename: Michel M J
authors.initials: MM
authors.lastname: Decre
authors.forename: Hubert C F
authors.initials: HC
authors.lastname: Martens
mesh_terms: D000465:Algorithms; D001369:Axons / Q000473:pathology; D003198:Computer Simulation; D003201:Computers; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D004867:Equipment Design; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D015233:Models, Statistical; D009186:Myelin Sheath / Q000473:pathology; D009474:Neurons / Q000473:pathology