title: Noncovalent liposome linkage and miniaturization of capsosomes for drug delivery.
abstract: We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assembled ∼1 μm diameter PMA(c)-based capsosomes, polymer hydrogel capsules that contain up to ∼2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Leticia
authors.initials: L
authors.lastname: Hosta-Rigau
authors.forename: Rona
authors.initials: R
authors.lastname: Chandrawati
authors.forename: Elli
authors.initials: E
authors.lastname: Saveriades
authors.forename: Pascal D
authors.initials: PD
authors.lastname: Odermatt
authors.forename: Almar
authors.initials: A
authors.lastname: Postma
authors.forename: Francesca
authors.initials: F
authors.lastname: Ercole
authors.forename: Kerry
authors.initials: K
authors.lastname: Breheney
authors.forename: Kim L
authors.initials: KL
authors.lastname: Wark
authors.forename: Brigitte
authors.initials: B
authors.lastname: Städler
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002214:Capsules / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047630:Depsipeptides / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D020100:Hydrogels; D008081:Liposomes / Q000737:chemistry*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008904:Miniaturization; D017239:Paclitaxel / Q000008:administration & dosage; D011109:Polymethacrylic Acids / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D002214:Capsules; D047630:Depsipeptides; D004337:Drug Carriers; D020100:Hydrogels; D008081:Liposomes; D011109:Polymethacrylic Acids; C109005:thiocoraline; D017239:Paclitaxel