title: The hemostatic system in patients with type 2 diabetes with and without cardiovascular disease.
abstract: The contribution of the hemostatic system in the development of cardiovascular disease (CVD) in patients with type 2 diabetes is not completely defined. The aim of this study was to elucidate associations of hemostatic factors with the development of CVD in patients with type 2 diabetes. Patients with type 2 diabetes without CVD (n = 113), with CVD (n = 94), and controls without CVD (n = 100) were enrolled in this study. Several hemostatic markers were measured. A disturbed hemostatic balance in patients with type 2 diabetes was observed as illustrated by hypofibrinolysis and increased levels of von Willebrand factor (vWF) and plasminogen-activator inhibitor 1 (PAI-1). Patients with type 2 diabetes with CVD have more thrombin generation compared to patients without CVD. This hemostatic imbalance might contribute to the development of CVD in patients with type 2 diabetes.
authors.affiliation: Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Chantal J N
authors.initials: CJ
authors.lastname: Verkleij
authors.forename: Roderick E de
authors.initials: RE
authors.lastname: Bruijn
authors.forename: Eelco W
authors.initials: EW
authors.lastname: Meesters
authors.forename: Victor E A
authors.initials: VE
authors.lastname: Gerdes
authors.forename: Joost C M
authors.initials: JC
authors.lastname: Meijers
authors.forename: Pauline F
authors.initials: PF
authors.lastname: Marx
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors