title: The utility of p16, E-cadherin and Ki67 in cervical squamous intraepithelial lesions diagnosis.
abstract: In this study, we included 26 cases diagnosed as squamous intraepithelial lesions, which were examined histopathologically, and in terms of p16, E-cadherin and Ki67 immunoexpression. In low-grade lesions, p16 expression was limited to one third below the epithelium, E-cadherin has a membranous pattern and Ki67 proliferation index had low values. In high-grade lesions, the p16 diffuse stain was present in two thirds or all epithelium layers, E-cadherin expression became aberrant, with membranous and cytoplasmic pattern and Ki67 proliferation index was high. These biomarkers have proven useful to accurately assess the extent of lesions and to identify lesions with high risk of progression.
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania. csimionescu2004@yahoo.com
authors.forename: Cristiana
authors.initials: C
authors.lastname: Simionescu
authors.forename: Cl
authors.initials: C
authors.lastname: Mărgăritescu
authors.forename: A
authors.initials: A
authors.lastname: Stepan
authors.forename: Claudia Valentina
authors.initials: CV
authors.lastname: Georgescu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Niculescu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Muntean
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D019394:Ki-67 Antigen