title: abeo-abietanes from Teucrium polium roots as protective factors against oxidative stress.
abstract: Six new 17(15→16)-abeo-abietanes, along with seven known compounds, were isolated and characterized from ethyl acetate root extract of Teucrium polium L., a medicinal plant belonging to the Labiatae family reported to have hypolipidemic, hypoglycaemic, anti-nociceptive and anti-inflammatory effects. Their structures were elucidated by 1D ((1)H, (13)C and DEPT) and 2D (COSY, TOCSY, HSQC, HMBC, and NOESY) NMR and mass spectral data. The antioxidative properties of pure metabolites were analyzed on the basis of their DPPH radical scavenging capability. The antioxidant capacity in cell-free systems of the isolated metabolites was carried out by measuring their capabilities to inhibit the synthesis of thiobarbituric acid reactive species in assay media using as oxidable substrates a vegetable fat and the pentose sugar 2-deoxyribose and to prevent oxidative damage of the bovine serum albumin (BSA) hydrosoluble protein. All of the compounds showed a significant and dose-response efficacy although weaker than that exercised by the standard Trolox®.
authors.affiliation: Dipartimento di Scienze della Vita, Laboratorio di Fitochimica, Seconda Università degli Studi di Napoli, via Vivaldi 43, I-81100 Caserta, Italy. antonio.fiorentino@unina2.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Fiorentino
authors.forename: Brigida
authors.initials: B
authors.lastname: D'Abrosca
authors.forename: Severina
authors.initials: S
authors.lastname: Pacifico
authors.forename: Monica
authors.initials: M
authors.lastname: Scognamiglio
authors.forename: Grazia
authors.initials: G
authors.lastname: D'Angelo
authors.forename: Pietro
authors.initials: P
authors.lastname: Monaco
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D020011:Protective Agents; D012710:Serum Albumin, Bovine; D031367:Teucrium / Q000737:chemistry
chemical_list: D045784:Abietanes; D016166:Free Radical Scavengers; D010936:Plant Extracts; D020011:Protective Agents; D012710:Serum Albumin, Bovine