title: A novel 18-norclerodane diterpenoid from the roots of Tinospora sagittata var. yunnanensis.
abstract: A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1-6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.
authors.affiliation: Key Laboratory of Ethnic Medicine Resource Chemistry, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China. fugmiao@yahoo.com.cn.
authors.forename: Xiang-Zhong
authors.initials: XZ
authors.lastname: Huang
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Cheng
authors.forename: Yun
authors.initials: Y
authors.lastname: Dai
authors.forename: Guang-Miao
authors.initials: GM
authors.lastname: Fu
authors.forename: Jun-Ming
authors.initials: JM
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Yin
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D031610:Tinospora / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D045785:Diterpenes, Clerodane