title: A neurophotonic device for stimulation and recording of neural microcircuits.
abstract: Neural stimulation and recording with high spatiotemporal precision is desirable for studying the real time cellular basis of neural circuits, as well as developing possible therapeutic treatments for neurological diseases. Optical stimulation of genetically targeted neurons expressing the light sensitive ion channel protein Channelrhodopsin (ChR2) and Halorhodopsin (NpHR) has recently been reported as a means for millisecond temporal control of neuronal spiking activity with cell-type selectivity. We combine the new 'optogenetics' approaches with a dual-modality device, which consists of a tapered coaxial optical waveguide ("optrode") directly integrated into a 36 element intra-cortical multi-electrode recording array (MEA). This novel optoelectronic microarray was cortically implanted in ChR2 transduced behaving rats. We have shown that the idiopathic induced epileptic seizure could be modulated by optical stimulation.
authors.affiliation: Department of Physics, Brown University, Providence, RI 02912, USA. Jing_Wang@brown.edu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: David A
authors.initials: DA
authors.lastname: Borton
authors.forename: Jiayi
authors.initials: J
authors.lastname: Zhang
authors.forename: Rebecca D
authors.initials: RD
authors.lastname: Burwell
authors.forename: Arto V
authors.initials: AV
authors.lastname: Nurmikko
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D004566:Electrodes; D004594:Electrophysiology / Q000295:instrumentation; D004827:Epilepsy; D025602:Halorhodopsins / Q000737:chemistry*; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D055095:Optics and Photonics / Q000379:methods; D010775:Photic Stimulation / Q000295:instrumentation; D017785:Photons; D051381:Rats; D020318:Rats, Long-Evans; D012243:Rhodopsin / Q000737:chemistry*; D013997:Time Factors
chemical_list: D025602:Halorhodopsins; D012243:Rhodopsin