title: Comparison of steady-state and transient blood flow simulations of intracranial aneurysms.
abstract: Hemodynamics play an important role in the pathogenesis of intracranial aneurysms and patient-specific computational hemodynamic simulations could provide valuable information to clinicians. Transient simulations that capture the pulsatility of blood flow are commonly used for research purposes. However, steady-state simulations might provide enough information at a lower computational cost, which could help facilitate the introduction of hemodynamic simulations into clinical practice. In this study, we compared steady-state simulations to transient simulations for two aneurysms. The effect of a change in flow rate waveform was investigated and virtual treatment techniques were employed to compare post-treatment flow reduction predictions. We found that the difference in the time-averaged wall shear stress on the aneurysm was less than 5% and the distribution of wall shear stress was qualitatively assessed to be very similar.
authors.affiliation: CISTIB - Universitat Pompeu Fabra and CIBER-BBN, Barcelona, Spain. arjan.geers@upf.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: Geers
authors.forename: I
authors.initials: I
authors.lastname: Larrabide
authors.forename: H G
authors.initials: HG
authors.lastname: Morales
authors.forename: A F
authors.initials: AF
authors.lastname: Frangi
mesh_terms: D000783:Aneurysm; D001783:Blood Flow Velocity; D002343:Carotid Artery, Internal / Q000473:pathology; D002533:Cerebral Angiography / Q000379:methods; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D015444:Exercise; D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000503:physiopathology*; D020768:Middle Cerebral Artery / Q000503:physiopathology; D008955:Models, Cardiovascular; D015233:Models, Statistical; D013314:Stress, Mechanical; D013997:Time Factors