title: In vivo measurement of the complex shear modulus of rat mammary tumors using shear wave imaging techniques.
abstract: This paper summarizes dynamic measurements of shear modulus constants acquired for spontaneously growing rat mammary tumors. Measurements are compared with histology to determine tumor types. We also report on 3D shear-wave velocity fields acquired from an inhomogeneous hydrogel phantom with known mechanical properties. Phantom measurements enable us to interpret the effects of tissue structure and geometry on viscoelastic parameter estimates, and demonstrate that reproducible measurements are possible in vivo. Viscoelastic properties describe the mechano-environment of cells undergoing malignant transformation and tumor growth.
authors.affiliation: Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. yuewang3@illinois.edu
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Marko
authors.initials: M
authors.lastname: Orescanin
authors.forename: Michael F
authors.initials: MF
authors.lastname: Insana
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D018226:Fibroadenoma / Q000000981:diagnostic imaging; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D018608:Ultrasonography, Doppler / Q000379:methods*; D016217:Ultrasonography, Mammary / Q000379:methods*
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate