title: [Dynamics of regeneration of epitheliocytes from gastric mucosa at different modes of antirelapse treatment of ulcer disease].
abstract: Exacerbation of duodenal ulcer disease (DUD) is associated with elevated number of Ki-67 and Bcl-2 positive endtotheliocytes and apoptotic activity. Inhibition of endotheliocyte proliferation and apoptotic activity in gastric mucosa (GM) upon eradication of Hp in DUD patients promotes ulcer healing. Combination of eradication with melaxen therapy substantially enhances efficiency of Hp elimination and reduces cicatrization time. Antirelapse treatment with melaxene and omeprazole normalizes endotheliocyte homeostasis on GM to a greater degree than omeprazole monotherapy.
authors.forename: A M
authors.initials: AM
authors.lastname: Osadchuk
authors.forename: F I
authors.initials: FI
authors.lastname: Komarov
authors.forename: M A
authors.initials: MA
authors.lastname: Osadchuk
authors.forename: E A
authors.initials: EA
authors.lastname: Islamova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D004847:Epithelial Cells / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008550:Melatonin / Q000627:therapeutic use*; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D055502:Secondary Prevention; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D000658:Amoxicillin; D017291:Clarithromycin; D008550:Melatonin; D009853:Omeprazole