title: Effect of pre- versus post-weaning environmental disturbances on social behaviour in mice.
abstract: Environmental factors are involved to various degrees in psychiatric diseases. Unfortunately, early-life manipulations have been rarely investigated in mice. Interestingly, given the advances in genetics, combination of environmental and genetic factors to get construct validity is now possible. Herein, spontaneous activity, anxiety-like behaviour, social behaviour and short term spatial working memory were assessed in mice after maternal separation or social isolation. Of note, social withdrawal was observed in both models suggesting that this aspect needs to be better considered in future studies, particularly in testing new treatments for schizophrenia.
authors.affiliation: GMPc, Groupe Mémoire et Plasticité comportementale, Université de Caen Basse-Normandie, 5, rue Vaubénard, 14032 Caen cedex, France. valentine.bouet@unicaen.fr
authors.forename: Valentine
authors.initials: V
authors.lastname: Bouet
authors.forename: Blandine
authors.initials: B
authors.lastname: Lecrux
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Tran
authors.forename: Thomas
authors.initials: T
authors.lastname: Freret
mesh_terms: D000818:Animals; D001007:Anxiety / Q000209:etiology / Q000523:psychology; D001522:Behavior, Animal; D004777:Environment; D008426:Maternal Deprivation; D051379:Mice; D012559:Schizophrenia / Q000209:etiology*; D012934:Social Isolation / Q000523:psychology*; D014886:Weaning