title: Anti-inflammation effects of Cordyceps sinensis mycelium in focal cerebral ischemic injury rats.
abstract: Brain ischemia-reperfusion (IR) triggers a complex series of biochemical events including inflammation. To test the neuroprotective efficacy of Cordyceps sinensis mycelium (CSM) in a rat model of focal cerebral IR, ischemic animals were treated with CSM. They were evaluated at 24 h after reperfusion for neurological deficit score. Furthermore, the mechanism of the anti-inflammatory potential of CSM in the regulation of nuclear factor kappaB, polymorphonuclear cells (PMN), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. CSM significantly inhibited IR-induced up-regulation of NF-kappaB activation and the brain production of IL-1β, TNF-α, iNOS, ICAM-1, and COX-2. Moreover, CSM suppressed infiltration of PMN. The study demonstrates the neuroprotective potential of CSM inhibition through anti-inflammation in a rat model of ischemia-reperfusion.
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, 100102, China. zhenquanliu@163.com
authors.forename: Zhenquan
authors.initials: Z
authors.lastname: Liu
authors.forename: Pengtao
authors.initials: P
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Huiling
authors.initials: H
authors.lastname: Tang
authors.forename: Jianyou
authors.initials: J
authors.lastname: Guo
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000628:therapy*; D032661:Cordyceps / Q000648:ultrastructure; D025282:Mycelium / Q000737:chemistry*; D018696:Neuroprotective Agents; D051381:Rats; D015427:Reperfusion Injury / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D018696:Neuroprotective Agents