title: Vaccination against Chlamydia genital infection utilizing the murine C. muridarum model.
abstract: Chlamydia trachomatis genital infection is a worldwide public health problem, and considerable effort has been expended on developing an efficacious vaccine. The murine model of C. muridarum genital infection has been extremely useful for identification of protective immune responses and in vaccine development. Although a number of immunogenic antigens have been assessed for their ability to induce protection, the majority of studies have utilized the whole organism, the major outer membrane protein (MOMP), or the chlamydial protease-like activity factor (CPAF). These antigens, alone and in combination with a variety of immunostimulatory adjuvants, have induced various levels of protection against infectious challenge, ranging from minimal to nearly sterilizing immunity. Understanding of the mechanisms of natural infection-based immunity and advances in adjuvant biology have resulted in studies that are increasingly successful, but a vaccine licensed for use in humans has not yet been brought to fruition. Here we review immunity to chlamydial genital infection and vaccine development using the C. muridarum model.
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot 511, Little Rock, AR 72205-7194, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Farris
authors.forename: Richard P
authors.initials: RP
authors.lastname: Morrison
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology* / Q000517:prevention & control*; D023502:Chlamydia muridarum / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice
chemical_list: D001428:Bacterial Vaccines