title: Dermatofibrosarcoma protuberans of the breast skin.
abstract: A case of a 26-year-old woman with dermatofibrosarcoma protuberans of the breast skin is described. She had noticed a palpable mass with redness 15 years previously, but it had begun to grow rapidly with swelling and redness two months before presenting. Ultrasonography and biopsy demonstrated a possibility of sarcoma of the breast. Wide excision was performed to confirm the diagnosis. Histologically, the tumor was composed of a uniform population of fibroblasts in a distinct storiform pattern. CD34 immunostaining showed diffuse reactivity. Platelet-derived growth factor β break-apart fluorescence in situ hybridization analysis showed a split-signal pattern which supported the diagnosis of dermatofibrosarcoma protuberans in the skin of the breast. It is important to diagnose a soft tissue lesion accurately when it occurs in the breast.
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Taeeun
authors.initials: T
authors.lastname: Kim
authors.forename: Yoon-La
authors.initials: YL
authors.lastname: Choi
authors.forename: Ha-Young
authors.initials: HY
authors.lastname: Park
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Song
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Shin
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Nam
authors.forename: Geunghwan
authors.initials: G
authors.lastname: Ahn
mesh_terms: D000328:Adult; D001940:Breast / Q000378:metabolism / Q000473:pathology*; D018223:Dermatofibrosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D020574:Proto-Oncogene Proteins c-sis / Q000096:biosynthesis / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D020574:Proto-Oncogene Proteins c-sis