title: Folate-decorated succinylchitosan nanoparticles conjugated with doxorubicin for targeted drug delivery.
abstract: Amphiphilic biodegradable succinylchitosan nanoparticles modified with folic acid are described that act as an emulsifier to form nanoparticles. Their molecular structures and physicochemical as well as self-assembly properties are characterized by means of FT-IR, ¹H NMR, FESEM, DLS, and TEM. The nanoparticles are 60-80 nm in size and are not toxic in vitro. They are immobilized with the cytostatic drug doxorubicin. Specific transport of doxorubicin by the nanoparticles into the folate-receptor-overexpressing cancer cells and its biological activity as well as in vitro release are demonstrated. It is shown that under acidic condition more drug is released. The nanoparticles can thus not only specifically deliver doxorubicin to its target, but also release the drug depending on the pH.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, W.B. 721302, India.
authors.forename: Sumanta Kumar
authors.initials: SK
authors.lastname: Sahu
authors.forename: Swatilekha
authors.initials: S
authors.lastname: Maiti
authors.forename: Tapas Kumar
authors.initials: TK
authors.lastname: Maiti
authors.forename: Sudip K
authors.initials: SK
authors.lastname: Ghosh
authors.forename: Panchanan
authors.initials: P
authors.lastname: Pramanik
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D005434:Flow Cytometry; D005492:Folic Acid / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007211:Indoles / Q000378:metabolism; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D008027:Light; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012542:Scattering, Radiation; D013194:Staining and Labeling; D013499:Surface Properties / Q000187:drug effects
chemical_list: D007211:Indoles; C118639:N-succinyl-chitosan; C007293:DAPI; D004317:Doxorubicin; D048271:Chitosan; D005492:Folic Acid