title: Lab-on-a-chip for the isolation and characterization of circulating tumor cells.
abstract: A smart miniaturized system is being proposed for the isolation and characterization of circulating tumor cells (CTCs) directly from blood. Different microfluidic modules have been designed for cell enrichment and -counting, multiplex mRNA amplification as well as DNA detection. With the different modules at hand, future effort will focus on the integration of the modules in a fully automated, single platform.
authors.affiliation: Imec, SSET-FNS, Kapeldreef 75, 3001 Heverlee, Belgium. tim.stakenborg@imec.be
authors.forename: Tim
authors.initials: T
authors.lastname: Stakenborg
authors.forename: Chengxu
authors.initials: C
authors.lastname: Liu
authors.forename: Olivier
authors.initials: O
authors.lastname: Henry
authors.forename: Ciara K
authors.initials: CK
authors.lastname: O'Sullivan
authors.forename: Christian
authors.initials: C
authors.lastname: Fermer
authors.forename: Tina
authors.initials: T
authors.lastname: Roeser
authors.forename: Marion
authors.initials: M
authors.lastname: Ritzi-Lehnert
authors.forename: Sigfried
authors.initials: S
authors.lastname: Hauch
authors.forename: Elin
authors.initials: E
authors.lastname: Borgen
authors.forename: Nadja
authors.initials: N
authors.lastname: Laddach
authors.forename: Liesbet
authors.initials: L
authors.lastname: Lagae
mesh_terms: D002469:Cell Separation / Q000295:instrumentation* / Q000379:methods; D003592:Cytophotometry / Q000295:instrumentation / Q000379:methods; D004273:DNA, Neoplasm / Q000302:isolation & purification; D006801:Humans; D056656:Lab-On-A-Chip Devices; D009369:Neoplasms / Q000097:blood* / Q000235:genetics / Q000473:pathology; D009360:Neoplastic Cells, Circulating; D016133:Polymerase Chain Reaction / Q000295:instrumentation / Q000379:methods
chemical_list: D004273:DNA, Neoplasm