title: Advanced MRI in Rosai-Dorfman disease: correlation with histopathology.
abstract: Rosai-Dorfman disease is an idiopathic benign lymphoproliferative disorder that can, on rare occasions, cause intracranial or intraspinal lesions with non-specific features on conventional imaging. For this reason, its diagnosis is based on the classical pathological findings of histiocyte proliferation and emperipolesis. In this case report, we describe the imaging features of Rosai-Dorfman disease as visualized by newer types of MRI sequences, such as diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI) and perfusion-weighted imaging (PWI). In fact, combining the findings of conventional cross-sectional imaging with high fractional anisotropy (FA), a low apparent diffusion coefficient (ADC), mild blooming on SWI and decreased perfusion can help to make the diagnosis of Rosai-Dorfman disease. These newer tools can also be used to clarify the pathology of Rosai-Dorfman disease.
authors.affiliation: Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India.
authors.forename: D
authors.initials: D
authors.lastname: Hingwala
authors.affiliation: Department of Neuropathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India.
authors.forename: R
authors.initials: R
authors.lastname: Neelima
authors.affiliation: Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India; Department of Neuropathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India. Electronic address: chandkesav@yahoo.com.
authors.forename: C
authors.initials: C
authors.lastname: Kesavadas
authors.affiliation: Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India.
authors.forename: B
authors.initials: B
authors.lastname: Thomas
authors.affiliation: Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India.
authors.forename: T R
authors.initials: TR
authors.lastname: Kapilamoorthy
authors.affiliation: Department of Neuropathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695011, India.
authors.forename: V V
authors.initials: VV
authors.lastname: Radhakrishnan
mesh_terms: D000328:Adult; D000465:Algorithms; D001927:Brain Diseases / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D015618:Histiocytosis, Sinus / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic