title: Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian.
abstract: Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the intestinal absorption of forsythoside A were investigated. The observations from in situ intestinal circulation model showed that A/%(h(-1)) of forsythoside A in FF+LSF, FF+SR and SHL were all reduced greatly compared with that in FF. However, in pharmacokinetics study, C(max) and AUC(0→1440) of forsythoside A all increased and T(1/2) prolonged in SHL, FF+LJF and FF+SR compared with FF. The results indicated that the different compositions of SHL decreased absorption but increased bioavailability of forsythoside A, which may be related to its metabolism inhibited in intestine or liver.
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Liu-qing
authors.initials: LQ
authors.lastname: Di
authors.forename: Jin-jun
authors.initials: JJ
authors.lastname: Shan
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Bi
authors.forename: Le-tian
authors.initials: LT
authors.lastname: Chen
authors.forename: Ling-chong
authors.initials: LC
authors.lastname: Wang
mesh_terms: D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D031657:Forsythia; D005638:Fruit; D006027:Glycosides / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D031239:Lonicera; D031364:Scutellaria baicalensis
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; C516400:shuang-huang-lian; C058049:forsythiaside