title: Tamoxifen affects the toxicokinetics of o,p'-DDT in male Nile Tilapia (Oreochromis niloticus).
abstract: The goal of the present study was to evaluate the role of Tamoxifen (TAM), in the distribution and/or elimination kinetics of o,p'-DDT, in male tilapias. A non-compartmental analysis was chosen to describe the time course of o,p'-DDT plasma concentrations. Mean plasma concentration of o,p'-DDT following IP administration indicates a very complex kinetic profile. Tamoxifen decreased the o,p'-DDT mean half-life (t½) from 20.38 to 16.11 days, the Mean Residence Time (MRT) from 28.7 to 23.23 days, and clearance (CL) from 0.0031 to 0.001 mL/min. The distribution pattern of o,p'-DDT in tissues and the clearance in plasma suggest that storage points mediated through the membrane-receptor lipophilicity can be involved.
authors.affiliation: Departmento de Recursos del Mar, Cinvestav del IPN, Km 6 Antigua Carretera a Progreso, Yucatán, C.P. 97310, Merida, Mexico.
authors.forename: María
authors.initials: M
authors.lastname: Del Rocío Barreto-Castro
authors.forename: Lisbeth Enith
authors.initials: LE
authors.lastname: Gómez-Martínez
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gold-Bouchot
mesh_terms: D000818:Animals; D023681:Cichlids / Q000097:blood*; D003634:DDT / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D052244:Endocrine Disruptors / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D006207:Half-Life; D008297:Male; D008657:Metabolic Clearance Rate; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*; D014018:Tissue Distribution
chemical_list: D052244:Endocrine Disruptors; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D003634:DDT; C016340:o,p'-DDT