title: Statistical correlations between peripheral blood lymphocyte subpopulations and tumor inflammatory infiltrate in stage I of skin melanoma.
abstract: The article presents statistical correlations of immune cell parameters investigated in patients diagnosed with skin melanoma stage I. Recent data indicate a suppressed immune response, probably sustained by immune-regulating molecules expressed or shed from the tumor. These molecules block an efficient immune response and thus the tumor develops. All the molecules that are part of the tumor escape mechanisms can be targets for immune-mediated anti-tumor agents. We try to find the significance of some immunohistochemical markers (UCHL1, CD4, CD8) in tumoral inflammatory infiltrate and to establish the statistical correlations between molecular markers and tumor grade and stage. The studied parameters were: CD3+, CD4+, CD8+, CD56+16+ and CD19+. The statistical results were performed with SPSS v. 15.0. We demonstrate that a CD4+ on-going immune response is elicited in the investigated patients. We found a possible compensatory mechanism between T-lymphocytes and NK-cells and also between the antibodies generating cells and the natural cytotoxic cells. We are confident that these statistical correlations between clinical, immunological and immunohistochemical data can be useful in the disease management and personalized immune-therapy.
authors.affiliation: Department of Pathology, Victor Babes, National Institute of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. m_costache_dermatopat@yahoo.com
authors.forename: Mariana
authors.initials: M
authors.lastname: Costache
authors.forename: Monica
authors.initials: M
authors.lastname: Neagu
authors.forename: Angela
authors.initials: A
authors.lastname: Petrescu
authors.forename: Carolina
authors.initials: C
authors.lastname: Constantin
authors.forename: Gina
authors.initials: G
authors.lastname: Manda
authors.forename: Camelia Doina
authors.initials: CD
authors.lastname: Vrabie
authors.forename: Maria
authors.initials: M
authors.lastname: Waller
authors.forename: C S
authors.initials: CS
authors.lastname: Petrescu
authors.forename: Olga
authors.initials: O
authors.lastname: Simionescu
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D056808:Biostatistics; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000473:pathology*; D008545:Melanoma / Q000097:blood* / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D012878:Skin Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology*
chemical_list: D015703:Antigens, CD