title: β-Arrestins: multifunctional signaling adaptors in type 2 diabetes.
abstract: β-arrestins are not only well-known negative regulators of G protein-coupled receptor (GPCR) signaling, but also important adaptors in modulating the strength and duration of cellular signaling by scaffolding and interacting with a lot of cytoplasmic proteins. While β-arrestins are rather well described signal-mediated molecules, they are not generally associated with insulin signaling. But recent work has confirmed the difference from original thought. The current review aims to explore the emerging roles for β-arrestins in regulating insulin action, inflammatory signal pathway and other cellular signaling which are associated with type 2 diabetes.
authors.affiliation: Institute of Chinese Integrative Medicine, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai, 200040, China.
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Feng
authors.forename: Wenjian
authors.initials: W
authors.lastname: Wang
authors.forename: Jibo
authors.initials: J
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D019390:Arrestins / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D000071557:beta-Arrestins
chemical_list: D019390:Arrestins; D007328:Insulin; D000071557:beta-Arrestins; D019869:Phosphatidylinositol 3-Kinases