title: Lower gastrointestinal tract cancer predisposition syndromes.
abstract: Although inherited predisposition to colorectal cancer (CRC) has been suspected for more than 100 years, definitive proof of Mendelian syndromes had to await maturation of molecular genetic technologies. Since the l980s, the genetics of several clinically distinct entities has been revealed. Five disorders that share a hereditary predisposition to CRC are reviewed in this article.
authors.affiliation: Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. shah.neel2@mayo.edu
authors.forename: Neel B
authors.initials: NB
authors.lastname: Shah
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D044483:Intestinal Polyposis / Q000151:congenital / Q000235:genetics; D009154:Mutation; D009386:Neoplastic Syndromes, Hereditary; D010580:Peutz-Jeghers Syndrome / Q000235:genetics; D012307:Risk Factors; D013577:Syndrome