title: Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity.
abstract: The present study examines the preventive role of hesperidin (HDN) on plasma, cardiac and hepatic lipids in isoproterenol (ISO)-induced rats. Myocardial injury was induced by subcutaneous injection of isoproterenol hydrochloride (85 mg/kg BW) twice at an interval of 24 h, for two consecutive days. HDN was administered by post-orally at a dose of 200 mg/kg BW. The results showed increased levels of plasma cholesterol, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), free fatty acids (FFA) and phospholipids (PL) and decreased level of high density lipoprotein-cholesterol (HDL-C) in ISO-induced rats. ISO rats also showed an increase in cholesterol, TG and FFA and decrease in PL levels in the heart and liver tissues. HDN treatment brought the above parameters towards normal level. This experiment shows that HDN possesses hypolipidemic effect in ISO-induced rats.
authors.affiliation: Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Selvaraj
authors.forename: Kodukkur Viswanathan
authors.initials: KV
authors.lastname: Pugalendi
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000633:toxicity; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects*; D006569:Hesperidin / Q000494:pharmacology*; D007545:Isoproterenol / Q000633:toxicity; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000032:analysis* / Q000097:blood; D008099:Liver / Q000187:drug effects*; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002316:Cardiotonic Agents; D008055:Lipids; D006569:Hesperidin; D007545:Isoproterenol