title: Evaluation of non-ampullary duodenal polyps: comparison of non-neoplastic and neoplastic lesions.
abstract: OBJECTIVE
  To evaluate duodenal polyps, divided into non-neoplastic and neoplastic lesions. In addition, the clinical characteristics of duodenal hyperplastic polyps are determined.
  
  
  METHODS
  We analyzed medical records of 50,114 consecutive patients submitted to for first diagnostic esophago-gastroduodenoscopy between January 2004 and December 2009. We excluded lesions on the ampulla of Vater and submucosal tumors. We studied 510 cases that were diagnosed endoscopically with duodenal polyps and enrolled a total of 221 cases that had undergone tissue biopsy. We analyzed the differences between non-neoplastic and neoplastic lesions, and determined the clinical features of duodenal hyperplastic polyps.
  
  
  RESULTS
  Non-neoplastic lesions were found in 196 patients and neoplastic lesions in 25 patients. On univariate analysis, there were significant differences in shape, location, and size. Polyps more than 10 mm in diameter or polyps in the second portion had independent risk factors for being neoplastic lesions, as identified by multivariate analysis. In 23 cases of hyperplastic polyps (79.3%), they were accompanied by gastro-duodenal pathology, which was possibly associated with Helicobacter pylori.
  
  
  CONCLUSIONS
  Polyps of more than 10 mm or polyps in the second portion of the duodenum should be evaluated by histological examination.
authors.affiliation: Department of Internal Medicine, College of Medicine, The Catholic University of Korea, St. Vincent's Hospital Ji-dong, Paldal-gu, Suwon Si, Gyeonggi-Do 442-723, South Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Jung
authors.forename: Woo Chul
authors.initials: WC
authors.lastname: Chung
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Kim
authors.forename: Seol Hye
authors.initials: SH
authors.lastname: Kim
authors.forename: Chang Nyol
authors.initials: CN
authors.lastname: Paik
authors.forename: Bo In
authors.initials: BI
authors.lastname: Lee
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Cho
authors.forename: Kang-Moon
authors.initials: KM
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D004378:Duodenal Diseases / Q000175:diagnosis / Q000473:pathology*; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D004386:Duodenum / Q000382:microbiology / Q000473:pathology*; D016145:Endoscopy, Digestive System; D005260:Female; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies