title: Many, but not all, outcome studies support exclusion of female plasma from the blood supply.
abstract: Transfusion-related acute lung injury (TRALI) has been identified as the most common cause of transfusion-related death. Although extensive literature supports restrictions on female-donor plasma to reduce antibody-mediated TRALI, only a few outcome studies have assessed for effects of this change, and some, but not all, have endorsed the policy. A recent report even suggests poorer outcomes in cardiac surgery patients with a shift to male-donor-only plasma, raising concerns that TRALI alone, whether catastrophic or more survivable, is insufficient compared with broader measures, such as short-term mortality or long-term survival, as an end point to assess for overall improvements in patient care.
authors.affiliation: Duke University Medical Center, Box 3094 DUMC, Durham, NC 27710, USA. staff002@mc.duke.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Stafford-Smith
authors.forename: Evelyn
authors.initials: E
authors.lastname: Lockhart
authors.forename: Nicholas
authors.initials: N
authors.lastname: Bandarenko
authors.forename: Ian
authors.initials: I
authors.lastname: Welsby
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000276:immunology*; D000906:Antibodies / Q000009:adverse effects* / Q000494:pharmacology; D001782:Blood Donors; D005260:Female; D006801:Humans; D008168:Lung / Q000276:immunology / Q000503:physiopathology; D008297:Male; D017063:Outcome Assessment, Health Care; D010949:Plasma / Q000276:immunology*; D057766:Policy; D012189:Retrospective Studies; D012737:Sex Factors; D065227:Transfusion Reaction
chemical_list: D000906:Antibodies