title: Micro vs macro electrode DBS stimulation: A dosimetric study.
abstract: Deep Brain Stimulation (DBS) is a clinically suitable technique for the treatment of the Parkinson's disease. Recently, also other neurological disorders such as Tourette syndrome, obsessive-compulsive disorder, epilepsy are being to be treated with DBS. However, the debate on its therapeutic mechanisms of action is still open. In order to a better understanding of such mechanisms, in this work the attention is focused on the DBS micro-stimulation. Indeed, a micro electrodes registration and stimulation is a fundamental step, during the surgical phase, to optimize the technique in terms of DBS lead positioning and DBS signal parameters. In this paper a dosimetric analysis with micro electrodes has been carried out, showing a more focused distribution of the electrical potential induced in the neuroanatomical tissues and changes of the excited/inhibited regions, respect to a macro electrodes stimulation.
authors.affiliation: ICEmB @ Department of Electronic Engineering, Univeristy of Rome "La Sapienza", 00184, Italy. maggio@die.uniromal.it
authors.forename: F
authors.initials: F
authors.lastname: Maggio
authors.forename: T
authors.initials: T
authors.lastname: Pasciuto
authors.forename: A
authors.initials: A
authors.lastname: Paffi
authors.forename: F
authors.initials: F
authors.lastname: Apollonio
authors.forename: M
authors.initials: M
authors.lastname: Parazzini
authors.forename: P
authors.initials: P
authors.lastname: Ravazzani
authors.forename: G
authors.initials: G
authors.lastname: d'Inzeo
mesh_terms: D001703:Biophysics / Q000379:methods; D003198:Computer Simulation; D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008962:Models, Theoretical; D009771:Obsessive-Compulsive Disorder / Q000628:therapy; D010300:Parkinson Disease / Q000628:therapy*; D011874:Radiometry / Q000379:methods; D005879:Tourette Syndrome / Q000628:therapy