title: Catalytic asymmetric Michael addition of α,β-unsaturated aldehydes to Ni(II) complexes of the Schiff base of glycine.
abstract: The conjugate addition of Ni(II) complexes of glycine Schiff base to α,β-unsaturated aldehydes catalyzed by (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine afforded adducts in excellent yields with up to 49:1 dr and 95% ee. This method enables the construction of two adjacent chiral centers in one step, and offers an alternative route to chiral α-amino acid derivatives.
authors.affiliation: Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Luo
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Jin
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Jiabin
authors.initials: J
authors.lastname: Gao
authors.forename: Weimin
authors.initials: W
authors.lastname: Yue
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
authors.forename: Jinxing
authors.initials: J
authors.lastname: Ye
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D005998:Glycine / Q000737:chemistry*; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D012545:Schiff Bases; D012997:Solvents; D009532:Nickel; D005998:Glycine