title: [Gene IL6 G(-174)C and gene IL10 G(-1082)A polymorphisms are associated with unfavourable outcomes in patients with acute coronary syndrome].
abstract: We investigated the association of gene IL6 G(-174)C polymorphism and gene IL10 G(-1082)A polymorphism with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St -Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 9.10 +/- 5.03 months (the maximum term 18 months). In case of gene IL10 G(-1082)A polymorphism we determined that patients with CAD diagnose and A alleles gene IL10 had unfavorable outcome more often than patients with homozygous G alleles. Survival time from end point from carrier genotype GA and AA is 11.68 +/- 0.67 months against 12.69 +/- 0.65 months from carrier phenotype GG gene IL10 (chi2 = 4.13, p = 0.042). The group studied do not differ significantly with respect to the distributions of gene IL6 G(-174)C alleles and genotypes. However in case combined group studies of gene IL10 G(-1082)A polymorphism and IL6 G(-174)C polymorphism we determined that patients with CAD diagnose and carrier genotype GG gene IL6 and genotype GA and AA gene IL10 had unfavorable outcome more often (survival time 11.01 +/- 1.24 months) than patients with genotype CC and CG gene IL6 and genotype GG gene IL10 (survival time 13.28 +/- 0.83 months) chi2 = 10.23, p = 0.017. The obtained data allows assuming the important role of the IL6 and IL10 genes which are responsible for functioning of inflammation system, in the accelerated formation of failures at the patients who had a coronary syndrome.
authors.forename: K A
authors.initials: KA
authors.lastname: Blagodatskikh
authors.forename: M A
authors.initials: MA
authors.lastname: Evdokimova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Agapkina
authors.forename: A G
authors.initials: AG
authors.lastname: Nikitin
authors.forename: A N
authors.initials: AN
authors.lastname: Brovkin
authors.forename: A A
authors.initials: AA
authors.lastname: Pushkov
authors.forename: E G
authors.initials: EG
authors.lastname: Blagodatskikh
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Kudriasheva
authors.forename: V S
authors.initials: VS
authors.lastname: Osmolovskaia
authors.forename: L O
authors.initials: LO
authors.lastname: Minushkina
authors.forename: M S
authors.initials: MS
authors.lastname: Kochkina
authors.forename: N D
authors.initials: ND
authors.lastname: Selezneva
authors.forename: E N
authors.initials: EN
authors.lastname: Dankovtseva
authors.forename: O S
authors.initials: OS
authors.lastname: Chumakova
authors.forename: T N
authors.initials: TN
authors.lastname: Baklanova
authors.forename: P A
authors.initials: PA
authors.lastname: Talyzin
authors.forename: N E
authors.initials: NE
authors.lastname: Reznichenko
authors.forename: O P
authors.initials: OP
authors.lastname: Donetskaia
authors.forename: S N
authors.initials: SN
authors.lastname: Tereshchenko
authors.forename: E S
authors.initials: ES
authors.lastname: Krasil'nikova
authors.forename: N A
authors.initials: NA
authors.lastname: Dzhaiani
authors.forename: E V
authors.initials: EV
authors.lastname: Akatova
authors.forename: M G
authors.initials: MG
authors.lastname: Glezer
authors.forename: A S
authors.initials: AS
authors.lastname: Galiavich
authors.forename: V B
authors.initials: VB
authors.lastname: Zakirova
authors.forename: N A
authors.initials: NA
authors.lastname: Kaziolova
authors.forename: I V
authors.initials: IV
authors.lastname: Timofeeva
authors.forename: A V
authors.initials: AV
authors.lastname: Iagoda
authors.forename: O I
authors.initials: OI
authors.lastname: Boeva
authors.forename: L I
authors.initials: LI
authors.lastname: Katel'nitskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Khorolets
authors.forename: S V
authors.initials: SV
authors.lastname: Shlyk
authors.forename: É G
authors.initials: ÉG
authors.lastname: Volkova
authors.forename: M P
authors.initials: MP
authors.lastname: Margarian
authors.forename: O I
authors.initials: OI
authors.lastname: Guz'
authors.forename: V O
authors.initials: VO
authors.lastname: Konstantinov
authors.forename: N V
authors.initials: NV
authors.lastname: Timofeeva
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
authors.forename: D A
authors.initials: DA
authors.lastname: Zateĭshchikov
authors.forename: V V
authors.initials: VV
authors.lastname: Nosikov
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000401:mortality*; D000368:Aged; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10