title: Adoptive cell therapy of prostate cancer using female mice-derived T cells that react with prostate antigens.
abstract: In this study, we report a novel treatment strategy that could potentially be used to improve efficacy of adoptive cell therapy for patients with prostate cancer. We show that female C57BL/6 mice are able to effectively reject two syngeneic prostate tumors (TRAMP-C2 and RM1) in a T cell-dependent manner. The protective antitumor immunity appears to primarily involve T cell responses reactive against general prostate tumor/tissue antigens, rather than simply to male-specific H-Y antigen. For the first time we show that adoptive transfer of lymphocytes from TRAMP-C2-primed or naïve female mice effectively control prostate tumor growth in male mice, when combined with host pre-conditioning (i.e., non-myeloablative lymphodepletion) and IL-2 administration. No pathological autoimmune response was observed in the treated tumor-bearing male mice. Our studies provide new insights regarding the immune-mediated recognition of male-specific tissue, such as the prostate, and may offer new immunotherapy treatment strategies for advanced prostate cancer.
authors.affiliation: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors.forename: Huanfa
authors.initials: H
authors.lastname: Yi
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Yu
authors.forename: Chunqing
authors.initials: C
authors.lastname: Guo
authors.forename: Masoud H
authors.initials: MH
authors.lastname: Manjili
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Repasky
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Wang
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D005260:Female; D006182:H-Y Antigen / Q000276:immunology; D016219:Immunotherapy, Adoptive; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D006182:H-Y Antigen