title: [Arterial hypertension and metabolic disorders].
abstract: Combination of arterial hypertension (AH) and metabolic disorders accelerates development of organic lesions in target organs. As shown in recent prospective studies, myocardial hypertrophy rate closely correlated with severity of metabolic disturbance. The thickness of interventricular septum and posterior wall show stronger dependence of severity of metabolic disorders than left ventricular density while left atrial enlargement is correlates with fasting glycemia and excess body mass. There is close relationship between microalbuminurea and hyperinsulinemia and the number of metabolic syndrome components is linearly correlated with glomerular filtration rate below 60 ml/min. It is shown that rigidity of arteries is a new independent risk factor of cardiovascular complications in obese patients. Moreover, metabolic disturbances cause affective disorders that impair quality of life and therapy motivation. Combination of AH, metabolic disturbances, and borderline psychic disorders dictated consideration of abnormal melatonin secretion as a condition developing as a consequence of disturbed adaptive circadian rhythms. This hypothesis was prompted by the discovery of the so-called "clock genes" in the central nervous system and practically all peripheral organs including heart, vessels, and adipose tissue.
authors.forename: I S
authors.initials: IS
authors.lastname: Dzherieva
authors.forename: N I
authors.initials: NI
authors.lastname: Volkova
mesh_terms: D056926:CLOCK Proteins / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D003863:Depression / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007674:Kidney Diseases / Q000209:etiology; D008550:Melatonin / Q000378:metabolism; D008659:Metabolic Diseases / Q000150:complications* / Q000503:physiopathology
chemical_list: D056926:CLOCK Proteins; D008550:Melatonin