title: Correlation between cerebral tissue and central venous oxygen saturation during off-pump coronary bypass graft surgery.
abstract: We compared simultaneous regional cerebral oxygen saturation and central venous oxygen saturation at different time periods in 20 adult patients (median age, 57.9; range, 35 to 76 years) undergoing off-pump coronary artery bypass (OPCAB) graft surgery (n= 20). Mean arterial pressure (MAP), partial pressure of carbon dioxide (PcvCO(2)), heart rate, haematocrit (Hct), lactate and patient oxygen saturation (SpO(2)) were also recorded as a secondary analysis to determine independent predictors of cerebral desaturation and interactions between predictors. The cross-sectional analysis performed at each time point showed several significant moderate to strong positive correlations between central venous oxygen saturation and both right and left cerebral oxygen saturations; however, right cerebral saturations correlated better with central venous saturations than left cerebral saturation. Partial pressure of carbon dioxide (PcvCO(2)) was identified as a major predictor of cerebral saturation 0.59 (p < 0.001). Central venous saturation can be used as a surrogate measure of cerebral oxygen saturation during OPCAB surgery.
authors.affiliation: Dept of Cardiothoracic Surgery, Inkosi Albert Luthuli Central Hospital, KZN, South Africa.
authors.forename: Yakeen
authors.initials: Y
authors.lastname: Harilall
authors.forename: Jamila K
authors.initials: JK
authors.lastname: Adam
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Biccard
authors.forename: Anu
authors.initials: A
authors.lastname: Reddi
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D047549:Coronary Artery Bypass, Off-Pump; D003430:Cross-Sectional Studies; D006801:Humans; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen