title: The use of human acellular dermal matrix for chest wall reconstruction.
abstract: BACKGROUND
  Reconstruction of chest wall defects has evolved, but challenges remain. This is particularly true when defects are large or contamination is present. Although numerous materials are available for reconstruction, acellular dermal matrix has the advantage of becoming vascularized and incorporated autologously. By its resistance to infection and lack of adhesion formation, it is a promising although expensive alternative to synthetic materials in some circumstances. This report examines our experience with human acellular dermal matrix (HADM) in reconstruction of major chest wall and diaphragmatic defects.
  
  
  METHODS
  A retrospective study was conducted of all patients who underwent thoracic reconstruction using HADM between March 2007 and March 2010 at Harbor-University of California-Los Angeles Medical Center. Data acquisition included demographics, surgical indications, operative details, complications, and follow-up evaluation.
  
  
  RESULTS
  Ten patients were identified. Indications included thoracic tumor resection in 5, Clagett procedure modification for postpneumonectomy empyema in 2, resection of chest wall osteomyelitis in 2, and pneumonectomy for multiple aspergillomata in 1. Complications occurred in 4 patients and included respiratory failure, pneumonia, and wound seromas. All wounds healed without need to remove or revise the HADM, and sound chest wall closure was achieved in every case.
  
  
  CONCLUSIONS
  HADM is an effective but expensive alternative to synthetic mesh in reconstruction of chest wall and diaphragmatic defects. It is particularly attractive for use under conditions of potential or overt contamination.
authors.affiliation: David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California.
authors.forename: Phillip S
authors.initials: PS
authors.lastname: Ge
authors.forename: Taryne A
authors.initials: TA
authors.lastname: Imai
authors.forename: Armen
authors.initials: A
authors.lastname: Aboulian
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Van Natta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D017768:Skin, Artificial; D013899:Thoracic Neoplasms / Q000601:surgery; D035441:Thoracic Wall / Q000601:surgery*; D013908:Thoracotomy; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult