title: Lipid dynamics in exocytosis.
abstract: Regulated exocytosis of neurotransmitter- and hormone-containing vesicles underpins neuronal and hormonal communication and relies on a well-orchestrated series of molecular interactions. This in part involves the upstream formation of a complex of SNAREs and associated proteins leading to the eventual fusion of the vesicle membrane with the plasma membrane, a process that enables content release. Although the role of lipids in exocytosis is intuitive, it has long been overlooked at least compared to the extensive work on SNAREs. Here, we will present the latest advances in this rapidly developing field revealing that lipids actually play an active role in exocytosis by focusing on cholesterol, 3'-phosphorylated phosphoinositides and phosphatidic acid.
authors.affiliation: Département Neurotransmission & Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Intégratives (UPR-3212), Centre National de Recherche Scientifique, Université de Strasbourg, 5 rue Blaise Pascal, 67084 Strasbourg, France. chasserot@unistra.fr
authors.forename: S
authors.initials: S
authors.lastname: Chasserot-Golaz
authors.forename: J R
authors.initials: JR
authors.lastname: Coorssen
authors.forename: F A
authors.initials: FA
authors.lastname: Meunier
authors.forename: N
authors.initials: N
authors.lastname: Vitale
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005089:Exocytosis; D006801:Humans; D050356:Lipid Metabolism; D008954:Models, Biological; D010712:Phosphatidic Acids / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism
chemical_list: D010712:Phosphatidic Acids; D010716:Phosphatidylinositols; D002784:Cholesterol