title: Analysis of HIV tropism in Ugandan infants.
abstract: HIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6-8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6-12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5-RLU at 6-8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Jessica D
authors.initials: JD
authors.lastname: Church
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Anthony
authors.initials: A
authors.lastname: Mwatha
authors.forename: Philippa
authors.initials: P
authors.lastname: Musoke
authors.forename: J Brooks
authors.initials: JB
authors.lastname: Jackson
authors.forename: Danstan
authors.initials: D
authors.lastname: Bagenda
authors.forename: Saad B
authors.initials: SB
authors.lastname: Omer
authors.forename: Deborah
authors.initials: D
authors.lastname: Donnell
authors.forename: Clemensia
authors.initials: C
authors.lastname: Nakabiito
authors.forename: Chineta
authors.initials: C
authors.lastname: Eure
authors.forename: Laura A
authors.initials: LA
authors.lastname: Guay
authors.forename: Allan
authors.initials: A
authors.lastname: Taylor
authors.forename: Paul M
authors.initials: PM
authors.lastname: Bakaki
authors.forename: Flavia
authors.initials: F
authors.lastname: Matovu
authors.forename: Michelle
authors.initials: M
authors.lastname: McConnell
authors.forename: Mary Glenn
authors.initials: MG
authors.lastname: Fowler
authors.forename: Susan H
authors.initials: SH
authors.lastname: Eshleman
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D015704:CD4 Antigens; D002478:Cells, Cultured; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000188:drug therapy / Q000401:mortality / Q000821:virology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019713:Receptors, CCR5 / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism; D013534:Survival; D014454:Uganda; D056189:Viral Tropism
chemical_list: D019380:Anti-HIV Agents; D015704:CD4 Antigens; D019713:Receptors, CCR5; D019718:Receptors, CXCR4