title: New insights into the formation of fungal aromatic polyketides.
abstract: Fungal aromatic polyketides constitute a large family of bioactive natural products and are synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their diverse structures arise from selective enzymatic modifications of reactive, enzyme-bound poly-β-keto intermediates. How iterative PKSs control starter unit selection, polyketide chain initiation and elongation, intermediate folding and cyclization, selective redox or modification reactions during assembly, and product release are central mechanistic questions underlying iterative catalysis. This Review highlights recent insights into these questions, with a particular focus on the biosynthetic programming of fungal aromatic polyketides, and draws comparisons with the allied biosynthetic processes in bacteria.
authors.affiliation: Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Crawford
authors.forename: Craig A
authors.initials: CA
authors.lastname: Townsend
mesh_terms: D001419:Bacteria / Q000378:metabolism; D053898:Biosynthetic Pathways; D005658:Fungi / Q000201:enzymology / Q000378:metabolism*; D018942:Macrolides / Q000378:metabolism*; D048630:Polyketide Synthases / Q000378:metabolism
chemical_list: D018942:Macrolides; D048630:Polyketide Synthases