title: L-asparaginase-induced complete response in a relapsed patient with Epstein-Barr virus and cytotoxic peripheral T-cell lymphoma not otherwise specified.
abstract: We present a patient with Epstein-Barr virus (EBV)-positive cytotoxic peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) who was successfully treated using only L-asparaginase. A 46-year-old Japanese man was diagnosed with EBV-positive cytotoxic PTCL-NOS. Although he underwent chemotherapy using multiple agents, he relapsed with hemophagocytic syndrome. L-asparaginase treatment was initiated at 6,000 U/m(2) on days 1, 3, 5, 10, and 12 together with prednisolone at 1 mg/kg. Although he developed grade 2 liver dysfunction and grade 2 coagulopathy, the patient achieved complete response status. Finally, he underwent allogeneic bone marrow stem cell transplantation, and he is currently still alive without disease at 24 months after the start of L-asparaginase therapy.
authors.affiliation: Department of Hematology, Shimane University Hospital, Izumo, Japan. ben2106t@med.shimane-u.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Ikejiri
authors.forename: Chie
authors.initials: C
authors.lastname: Onishi
authors.forename: Koshi
authors.initials: K
authors.lastname: Kawakami
authors.forename: Masaya
authors.initials: M
authors.lastname: Inoue
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miyake
authors.forename: Junko
authors.initials: J
authors.lastname: Tanaka
authors.forename: Asuka
authors.initials: A
authors.lastname: Araki
authors.forename: Riruke
authors.initials: R
authors.lastname: Maruyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Junji
authors.initials: J
authors.lastname: Suzumiya
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001215:Asparaginase / Q000627:therapeutic use*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents; D001215:Asparaginase