title: Duboscic acid: a potent α-glucosidase inhibitor with an unprecedented triterpenoidal carbon skeleton from Duboscia macrocarpa.
abstract: Duboscic acid (1), a triterpenoid with a unique carbon backbone, was isolated from Duboscia macrocarpa Bocq. It is the first member of a new class of triterpenoids, for which the name "dubosane" is proposed. Duboscic acid has a potent α-glucosidase inhibition, and its structure was unambiguously deduced by a single-crystal X-ray diffraction study.
authors.affiliation: Department of Organic Chemistry, Higher Teachers' Training College, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon. wafopascal@yahoo.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Wafo
authors.forename: Ramsay S T
authors.initials: RS
authors.lastname: Kamdem
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Shazia
authors.initials: S
authors.lastname: Anjum
authors.forename: Shamsun Nahar
authors.initials: SN
authors.lastname: Khan
authors.forename: Afshan
authors.initials: A
authors.lastname: Begum
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
authors.forename: Berhanu M
authors.initials: BM
authors.lastname: Abegaz
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D031583:Althaea / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D008958:Models, Molecular; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D014315:Triterpenes; C555573:duboscic acid