title: IL-17 family member cytokines: regulation and function in innate immunity.
abstract: Recently, the IL-17 family member cytokines have become prominent subjects of investigation. IL-17 (IL-17A) is the best-described member of this family where its production has been mainly attributed to a specialized T helper subset of the adaptive immune response termed Th17. However, recent research on this and other Th17 cytokines has revealed new sources and functions of IL-17 family members in the innate immune response. This review will highlight recent advances in the field of IL-17 family member cytokines and will predominantly focus on the innate regulation and function of IL-17, IL-17F, and IL-25.
authors.affiliation: Department of Immunology and Center for Inflammation and Cancer, M.D. Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Reynolds
authors.forename: Pornpimon
authors.initials: P
authors.lastname: Angkasekwinai
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D006373:Helminthiasis / Q000517:prevention & control; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007113:Immunity, Innate / Q000502:physiology*; D007249:Inflammation / Q000209:etiology; D020381:Interleukin-17 / Q000276:immunology / Q000502:physiology*; D007694:Killer Cells, Natural / Q000502:physiology; D008171:Lung Diseases / Q000209:etiology; D008264:Macrophages / Q000502:physiology; D055611:Natural Killer T-Cells; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000502:physiology; D058504:Th17 Cells / Q000502:physiology*
chemical_list: C486701:IL25 protein, human; D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3