title: [Changing patterns in the clinical, pathological features of Hodgkin lymphoma].
abstract: Hodgkin lymphoma shows a well-known geographic pattern, but temporal changes have been found recently as well.
  
  
  METHODS
  The Authors analyzed 439 Hodgkin lymphoma patients' clinicopathological and treatment data. Patients were treated at our department from 1980 until the end of 2008.
  
  
  RESULTS
  The first period contained 117 patients, the second 147 and third 115 Hodgkin lymphoma patients. The mean age of the patients was 40.1, 35.9 and 36.8 years in order. The male/female ratio: 1.42, 1.45, 1.04 in order. The incidence of mixed cellularity histological subtype is decreasing; nodular sclerosis shows an increasing tendency. The number of early stage patients (59.12%) is beyond the advanced stage (40%) in the last decade. The 10-year overall survival data were progressing 44.1%, 70.6% and 90.5% (survival prognosis) in the last decade.
  
  
  CONCLUSIONS
  Changes can be explained by the altered nature of Hodgkin lymphoma, the changes in socioeconomic status and the development of diagnostic and therapy methods.
authors.affiliation: Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Belgyógyászati Intézet, III. Belgyógyászati Klinika Debrecen Móricz Zs. krt. 22. 4032. mil03@freemail.hu
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Miltényi
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Simon
authors.forename: Edit
authors.initials: E
authors.lastname: Páyer
authors.forename: László
authors.initials: L
authors.lastname: Váróczy
authors.forename: Lajos
authors.initials: L
authors.lastname: Gergely
authors.forename: Adám
authors.initials: A
authors.lastname: Jóna
authors.forename: Arpád
authors.initials: A
authors.lastname: Illés
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D017678:Sex Distribution; D012959:Socioeconomic Factors; D016019:Survival Analysis; D016896:Treatment Outcome