title: [Initial observation of oxygen carriers with acute myocardial infarction in rats].
abstract: The purpose of this study was to test whether oxygen carriers could decrease tissue injury in a rat model of acute myocardial infarct. The study included 3 groups: SD rats in group II and group III were subjected to permanent occlusion of their left anterior descending coronary arteries; SD rats in group I were subjected to sham-operation. The success of modeling was assartained by ECG. Then the rats were given drug via caudal veins for 2 days. A quantitative evaluation was made with an automatic device for interpretation of cardiac troponin T (cTnT); heart staining was made for the calculation of myocardial infarction size (MIS); and myocardial tissue was taken and subjected to routine pathological hematoxylin-eosin (HE) staining for showing myocardial cell injury. cTnT in the sham-operation group was significantly lower by comparison with that in the model group (P < 0.01), and it was slightly lower in the oxygen carriers group than that in the model group, but there was no statistically significant difference (P = 0.18); MIS was significantly smaller in the sham-operation group than that in the model group (P < 0.01), and it was greater in the model rats than that in the oxygen carriers rats (P < 0.05). HE staining of myocardicum in the oxygen carriers group was significantly better than that in the model group (P < 0.01). The evidence suggested that oxygen carriers increased oxygen supply to ischemic myocardium, reduced the myocardial injury, and thus might offer a novel treatment of myocardial infarction.
authors.affiliation: Department of Physiology, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Xiangfang
authors.initials: X
authors.lastname: Zhao
authors.forename: Xuelong
authors.initials: X
authors.lastname: Jin
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Wang
authors.forename: Chengmin
authors.initials: C
authors.lastname: Yang
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D006454:Hemoglobins / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020107:Troponin T / Q000378:metabolism*
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; D020107:Troponin T; D010100:Oxygen