title: Correlation of diffusion and perfusion MRI with Ki-67 in high-grade meningiomas.
abstract: OBJECTIVE
  Atypical and anaplastic meningiomas have a greater likelihood of recurrence than benign meningiomas. The risk for recurrence is often estimated using the Ki-67 labeling index. The purpose of this study was to determine the correlation between Ki-67 and regional cerebral blood volume (rCBV) and between Ki-67 and apparent diffusion coefficient (ADC) in atypical and anaplastic meningiomas.
  
  
  METHODS
  A retrospective review of the advanced imaging and immunohistochemical characteristics of atypical and anaplastic meningiomas was performed. The relative minimum ADC, relative maximum rCBV, and specimen Ki-67 index were measured. Pearson's correlation was used to compare these parameters.
  
  
  RESULTS
  There were 23 cases with available ADC maps and 20 cases with available rCBV maps. The average Ki-67 among the cases with ADC maps and rCBV maps was 17.6% (range, 5-38%) and 16.7% (range, 3-38%), respectively. The mean minimum ADC ratio was 0.91 (SD, 0.26) and the mean maximum rCBV ratio was 22.5 (SD, 7.9). There was a significant positive correlation between maximum rCBV and Ki-67 (Pearson's correlation, 0.69; p = 0.00038). However, there was no significant correlation between minimum ADC and Ki-67 (Pearson's correlation, -0.051; p = 0.70).
  
  
  CONCLUSIONS
  Maximum rCBV correlated significantly with Ki-67 in high-grade meningiomas.
authors.affiliation: Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY 14620, USA. ginatd01@gmail.com
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Ginat
authors.forename: Rajiv
authors.initials: R
authors.lastname: Mangla
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Yeaney
authors.forename: Henry Z
authors.initials: HZ
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen