title: Sorting out frontotemporal dementia?
abstract: Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) cause the neurodegenerative disease frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U). The receptor for PGRN in the CNS has not been previously identified. In this issue of Neuron, Hu and colleagues identify Sortilin (SORT1) as a key neuronal receptor for PGRN that facilitates its endocytosis and regulates PGRN levels in vitro and in vivo.
authors.affiliation: Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive BMS J-483, Gainesville, FL 32610-0244, USA. jada.lewis@mbi.ufl.edu
authors.forename: Jada
authors.initials: J
authors.lastname: Lewis
authors.forename: Todd E
authors.initials: TE
authors.lastname: Golde