title: Platelet count and erythrocyte sedimentation rate are good predictors of Kawasaki disease: ROC analysis.
abstract: OBJECTIVE
  Kawasaki disease (KD) is the leading cause of acquired pediatric cardiac disease and requires a timely diagnosis. Available effective therapy is ideally administered within 10 days of illness diagnosis. Recent reports of several laboratory tests in KD have been published. In this study, we aimed to evaluate the sensitivity and specificity of several laboratory tests.
  
  
  METHODS
  We performed a retrospective study of consecutive patients diagnosed with KD from January to December 2008. We studied the sensitivity and specificity of several different tests [T-cell subgroups, platelet count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)] to predict KD using receiver operator characteristic curve analysis.
  
  
  RESULTS
  No significant difference was demonstrated in T-cell subgroups between patients with KD and referent patients (P>0.05). However, platelet count, ESR, and CRP were significantly higher in patients with KD than in referent patients (P<0.05). ESR showed a sensitivity of 93.9% and specificity of 83.3% with a cut-off of 15  mm/hr (area under the curve [AUC], 89.1%; P=0.03). Platelet count showed a sensitivity of 70.6% and specificity of 75% with a cut-off of 336.5×10(9)/l (AUC, 71.2%; P=0.03).
  
  
  CONCLUSIONS
  These results indicate that platelet count and ESR are good predictors of KD.
authors.affiliation: Clinical Laboratory Department, The First Hospital Affiliated to Xiamen University, Xiamen, China. songxyxm@hotmail.com
authors.forename: Song
authors.initials: S
authors.lastname: Xiu-Yu
authors.forename: Huang
authors.initials: H
authors.lastname: Jia-Yu
authors.forename: Hong
authors.initials: H
authors.lastname: Qiang
authors.forename: Dai
authors.initials: D
authors.lastname: Shu-Hui
mesh_terms: D001799:Blood Sedimentation; D002648:Child; D002675:Child, Preschool; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000175:diagnosis*; D010976:Platelet Count; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity