title: Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels.
abstract: Despite the continuous interest in organogels and hydrogels of low molecular weight gelators (LMWG), establishing the relationship between the molecular structure and the gelation mechanism is still a challenge. In this paper our interest focuses on the consequences of slight molecular modifications on the self-assembling behaviour of β-Ala vs Gly-Gly-based hydrogelators. Previously, in our group, amino acid based amphiphiles i.e. Gly-Gly-His-EO₂-Alk, a trimodular amphiphile (containing three domains: H-bond donor and acceptor/hydrophilic/hydrophobic domain, respectively) were reported to act as hydrogelators and that the gelation properties were related to hydrogen bonding, hydrophobic interactions and π-π stacking. Herein, β-Ala-His-EO₂-Alk was fully characterised by FT-IR, NMR, SAXS and SEM and the gelation mechanism is discussed. It appears that the number of amide groups determines the self-assembling behaviour into 1D or 2D/3D networks as a result of intimate interactions between gelator molecules.
authors.affiliation: LERMAB - EA 4370, Nancy-Université, BP 70239, F-54506 Vandoeuvre-lès-Nancy, France. Andrea.Pasc@lermab.uhp-nancy.fr
authors.forename: Andreea
authors.initials: A
authors.lastname: Pasc
authors.forename: Firmin
authors.initials: F
authors.lastname: Obounou Akong
authors.forename: Sedat
authors.initials: S
authors.lastname: Cosgun
authors.forename: Christine
authors.initials: C
authors.lastname: Gérardin