title: Novel findings in drug-induced dendritic cell tolerogenicity.
abstract: Dendritic cells (DCs) constitute a unique set of antigen-presenting cells (APCs), equipped with the potential to initiate strong immune responses as well as to critically regulate immunity. Tolerogenic or "alternatively activated" DCs show remarkable properties in regulating immune responses both in vitro and in vivo. Furthermore, tolerogenic DCs are now beginning to be tested in clinical studies. Use of pharmacological agents to induce maturation-resistant tolerogenic DCs is a popular approach. In this review, we will discuss already recognized, as well as recently discovered, potential pharmacological agents, their mechanism of action, and the way in which they induce tolerance in DCs.
authors.affiliation: Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia, and Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. svajgerurban@yahoo.com
authors.forename: Urban
authors.initials: U
authors.lastname: Svajger
authors.forename: Nataša
authors.initials: N
authors.lastname: Obermajer
authors.forename: Matjaž
authors.initials: M
authors.lastname: Jeras
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002986:Clinical Trials as Topic; D000242:Cyclic AMP / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology*; D055808:Drug Discovery / Q000639:trends; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016328:NF-kappa B / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism; D058906:Purinergic P1 Receptor Agonists / Q000494:pharmacology; D018336:Receptors, Aryl Hydrocarbon / Q000819:agonists; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology
chemical_list: D056572:Histone Deacetylase Inhibitors; D007166:Immunosuppressive Agents; D016328:NF-kappa B; D047495:PPAR gamma; D058906:Purinergic P1 Receptor Agonists; D018336:Receptors, Aryl Hydrocarbon; D000242:Cyclic AMP