title: Genomic polymorphisms of the innate immune system and allogeneic stem cell transplantation.
abstract: Allogeneic stem cell transplantation (allo-HSCT) is largely employed for treating patients affected by many hematological disorders, but despite the considerable improvement in the treatment of its complications, graft-versus-host disease and infections remain important causes of morbidity and mortality. Innate immunity is crucial in the immune defense against infections after allo-HSCT, and in the biological reactions leading to graft-versus-host disease. Thus, the innate immune system plays an important role in allo-HSCT clinical outcome. It is known now that cytokine gene polymorphisms greatly influence the outcome of allo-HSCT. In addition, genetic variability of some pattern-recognition receptors and antimicrobial peptides represent a promising field to be researched for allo-HSCT impact. Furthermore, more recent work suggests the importance of genetic variability between donor and recipient in the killer cell immunoglobulin-like receptors of the natural killer cells on the allo-HSCT outcome. This article discusses the main cytokines and innate immune gene polymorphisms influencing allo-HSCT outcome, presents new innate immune genes with promising expectations and points at the importance of genetic variability in natural killer cells in allo-HSCT outcome.
authors.affiliation: Hematology Department/Hospital Clínic of Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Avenida Villarroel 170, 08036-Barcelona, Spain. bmartina@clinic.ub.es
authors.forename: Beatriz
authors.initials: B
authors.lastname: Martín-Antonio
authors.forename: Miquel
authors.initials: M
authors.lastname: Granell
authors.forename: Alvaro
authors.initials: A
authors.lastname: Urbano-Ispizua
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D014644:Genetic Variation; D006086:Graft vs Host Disease / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000378:metabolism; D014184:Transplantation, Homologous / Q000276:immunology*
chemical_list: D023181:Antimicrobial Cationic Peptides; D016207:Cytokines; D051192:Receptors, Pattern Recognition