title: Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action.
abstract: Lysophosphatidic acid (LPA) is a lipid mediator required for maintaining homeostasis of numerous physiological functions and also involved in development of some pathological processes through interactions with G protein-coupled receptors. Recently many data have appeared about the role of this phospholipid in humans, but pathways of LPA biosynthesis and mechanisms of its action remain unclear. This review presents modern concepts about biosynthesis, reception, and biological activity of LPA in humans. Natural and synthetic LPA analogs are considered in the view of their possible use in pharmacology as agonists and/or antagonists of G protein-coupled receptors of LPA.
authors.affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia. i_berdichevets@hotbox.ru
authors.forename: I N
authors.initials: IN
authors.lastname: Berdichevets
authors.forename: T V
authors.initials: TV
authors.lastname: Tyazhelova
authors.forename: Kh R
authors.initials: KhR
authors.lastname: Shimshilashvili
authors.forename: E I
authors.initials: EI
authors.lastname: Rogaev
mesh_terms: D006801:Humans; D008049:Lipase / Q000235:genetics / Q000378:metabolism; D008246:Lysophospholipids / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism; D043264:Phosphodiesterase I / Q000235:genetics / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D000099189:Lysophospholipase D
chemical_list: D008049:Lipase; D008246:Lysophospholipids; D009097:Multienzyme Complexes; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D043562:Receptors, G-Protein-Coupled; D000099189:Lysophospholipase D; C504173:LIPC protein, human; C032881:lysophosphatidic acid