title: [An antimicrobial resistance surveillance of gram-positive cocci isolated from 12 teaching hospitals in China in 2009].
abstract: OBJECTIVE
  To investigate antimicrobial resistance among gram-positive cocci in China in 2009.
  
  
  METHODS
  From June to December 2009, 1169 consecutive and non-repetitive gram-positive cocci were collected from 12 teaching hospitals at 9 cities. The minimal inhibitory concentration (MIC) of antibacterial agents was determined by agar dilution method.
  
  
  RESULTS
  The prevalences of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococci (MRCoNS) were 45.3% (211/466) and 89.5% (214/239), respectively. The isolation rate of MRSA was 33.3% - 68.1% from different samples. All Staphylococci isolates were susceptible to vancomycin, teicoplanin and linezolid. Five point five percent (7/128) E.faecium strains were resistant to vancomycin. All E. faecalis strains were susceptible to vancomycin. About 99.1% (108/109) of E.faecalis and E.faecium were susceptible to linezolid. The prevalence of penicillin-intermediate Streptococcus pneumoniae (PISP) was 21.6% (48/222). Only 1 (0.5%, 1/222) Streptococcus pneumoniae strain was resistant to penicillin. Teicoplanin, vancomycin, linezolid and tigecycline were the most active agents against Streptococcus pneumoniae (susceptible rate 100%).
  
  
  CONCLUSIONS
  The high prevalence of methicillin-resistance is among Staphylococcus strains. Different samples show a different MRSA prevalence. Teicoplanin, vancomycin and linezolid show very high activity to Staphylococci, E. faecalis, E. faecium and Streptococcus pneumoniae.
authors.affiliation: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Hong-li
authors.initials: HL
authors.lastname: Sun
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Min-jun
authors.initials: MJ
authors.lastname: Chen
authors.forename: Ying-mei
authors.initials: YM
authors.lastname: Liu
authors.forename: Zhi-dong
authors.initials: ZD
authors.lastname: Hu
authors.forename: Kang
authors.initials: K
authors.lastname: Liao
authors.forename: Yun-zhuo
authors.initials: YZ
authors.lastname: Chu
authors.forename: Jin-e
authors.initials: JE
authors.lastname: Lei
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Yun-song
authors.initials: YS
authors.lastname: Yu
authors.forename: Bi-jie
authors.initials: BJ
authors.lastname: Hu
authors.forename: Zi-yong
authors.initials: ZY
authors.lastname: Sun
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qi-yong
authors.initials: QY
authors.lastname: He
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China; D024881:Drug Resistance, Bacterial; D006095:Gram-Positive Cocci / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D006784:Hospitals, Teaching; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents