title: [Development of anti-trypanosome drugs targeting nucleotides biosynthesis and red-ox regulatory pathway].
authors.affiliation: kitak@m.u-tokyo.ac.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kita
authors.forename: Daniel Ken
authors.initials: DK
authors.lastname: Inaoka
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Harada
mesh_terms: D000818:Animals; D000090722:Dihydroorotate Dehydrogenase; D015195:Drug Design; D004734:Energy Metabolism; D005650:Fumarates; D009711:Nucleotides / Q000096:biosynthesis*; D009963:Orotic Acid / Q000031:analogs & derivatives; D010084:Oxidation-Reduction; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000737:chemistry* / Q000502:physiology*; D010094:Oxonic Acid; D011487:Protein Conformation; D019802:Succinic Acid; D014344:Trypanocidal Agents; D014349:Trypanosoma cruzi / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000090722:Dihydroorotate Dehydrogenase; D005650:Fumarates; D009711:Nucleotides; D014344:Trypanocidal Agents; C004768:4,5-dihydroorotic acid; D010094:Oxonic Acid; D009963:Orotic Acid; C032005:fumaric acid; D019802:Succinic Acid; D044925:Oxidoreductases Acting on CH-CH Group Donors