title: Minor extended-spectrum β-lactamases.
abstract: Over the last few decades, various extended-spectrum β-lactamases (ESBLs), which are remotely related to the classical TEM and SHV families, have emerged. Among these, CTX-M, VEB and PER variants are of particular interest due to their widespread dissemination. This article will focus on these emerging ESBLs. CTX-M was first identified from an Escherichia coli strain in Germany and since then, a rapidly growing family of ESBLs has formed worldwide. There are now more than 90 CTX-M variants. VEB-1 ESBL is widespread in Southeast Asia. It was first identified in an E. coli strain isolated from a Vietnamese boy in 1996. After the initial discovery, it spread to other species. PER-1, now reported from various continents, was restricted to Turkish hospitals for years after the first identification in a strain of Pseudomonas aeruginosa in 1993. The worldwide dissemination of ESBLs is a healthcare crisis that deserves special attention.
authors.affiliation: Ankara Numune Egitim ve Araştrma Hastanesi, Enf. Hst & Klin. Mikr. Klinigi, Ankara 06100, Turkey.
authors.forename: Esragul
authors.initials: E
authors.lastname: Akinci
authors.forename: Haluk
authors.initials: H
authors.lastname: Vahaboglu
mesh_terms: D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D029968:Escherichia coli Proteins; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D065093:beta-Lactamase Inhibitors; C071167:beta-lactamase CTX-2; C108863:beta-lactamase PER-1; C055184:beta-lactamase TEM-3; C119424:beta-lactamase VEB-1, E coli; D001618:beta-Lactamases