title: [Using systemic corticotherapy for adult gonococcal keratoconjunctivitis: three case reports].
abstract: BACKGROUND
  adult gonococcal keratoconjunctivitis is a rare disease possibly leading to blindness, whose severity is related to the risk of corneal perforation and whose progression is conditioned by the rapidity of diagnosis and therapeutic management.
  
  
  OBJECTIVE
  discuss the value of general corticotherapy in the treatment of scleritis associated with this disease.
  
  
  METHODS
  retrospective analysis of patients with adult gonococcal keratoconjunctivitis managed in an emergency setting in 2007.
  
  
  METHODS
  three patients aged 22-55 years contracted the disease during unprotected sexual activity. Involvement was bilateral in two cases out of three; the intensity of the signs was always asymmetrical. Each patient underwent stromal melting of the superior limbic structures, with severity proportional to the delay in treatment. For each case, systemic and local antibiotics did not control corneal thinning, which seemed correlated with the intensity of the systematically associated signs of scleral inflammation. Treatment of scleritis with general corticotherapy under antibiotic cover stabilized the corneal thickness.
  
  
  CONCLUSIONS
  whether the physiopathology of perilimbic corneal thinning can lead to ocular perforation in this condition is unknown. In our experience, the stabilization of corneal thickness seems correlated with regression of the scleritis observed after introducing general corticotherapy, potentially indicating aseptic inflammatory involvement.
  
  
  CONCLUSIONS
  stromal melting of the limbus observed in adult gonococcal keratoconjunctivitis seems to be related to the associated scleritis. Systemic corticotherapy controls progression and reduces the risk of corneal perforation.
authors.affiliation: Service d'ophtalmologie, hôpital Edouard-Herriot, pavillon C, université Lyon-1, 5, place d'Arsonval, 69003 Lyon, France. murielpoli@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Poli
authors.forename: P L
authors.initials: PL
authors.lastname: Cornut
authors.forename: H
authors.initials: H
authors.lastname: Janin
authors.forename: S
authors.initials: S
authors.lastname: Perignon
authors.forename: D
authors.initials: D
authors.lastname: Donate
authors.forename: P
authors.initials: P
authors.lastname: Denis
authors.forename: C
authors.initials: C
authors.lastname: Burillon
mesh_terms: D005938:Glucocorticoids / Q000627:therapeutic use*; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007637:Keratoconjunctivitis / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D005938:Glucocorticoids