title: Stabilizing G-quadruplex DNA by a scissors-shaped binaphthyl derivative through the entangling mode: cooperation of binaphthylene and the ethoxy chain.
abstract: A scissors-shaped binaphthyl derivative (NPA) has been found to stabilize the G-quadruplex by intertwisting the whole G-quadruplex with two long chains, through the cooperation of the two functional groups: binaphthylene and the ethoxy chain. Moreover, NPA exhibits a good inhibitory effect of telomerase activity as well as excellent cytotoxic activity against HepG-2 human liver cancer cells.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Xiang
authors.forename: Hai-Yu
authors.initials: HY
authors.lastname: Hu
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Jin
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Li
authors.forename: Yalin
authors.initials: Y
authors.lastname: Tang
authors.forename: Chuan-Feng
authors.initials: CF
authors.lastname: Chen
mesh_terms: D001665:Binding Sites; D004355:Drug Stability; D005019:Ethyl Ethers / Q000737:chemistry* / Q000378:metabolism; D054856:G-Quadruplexes; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D009281:Naphthalenes / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D011485:Protein Binding / Q000187:drug effects; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism
chemical_list: D005019:Ethyl Ethers; D009281:Naphthalenes; D019098:Telomerase