title: Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein.
abstract: AI-2 is an autoinducer made by many bacteria. LsrB binds AI-2 in the periplasm, and Tsr is the l-serine chemoreceptor. We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.
authors.affiliation: 3122 TAMU, Texas A&M University, College Station, TX 77843-3122, USA.
authors.forename: Manjunath
authors.initials: M
authors.lastname: Hegde
authors.forename: Derek L
authors.initials: DL
authors.lastname: Englert
authors.forename: Shanna
authors.initials: S
authors.lastname: Schrock
authors.forename: William B
authors.initials: WB
authors.lastname: Cohn
authors.forename: Christian
authors.initials: C
authors.lastname: Vogt
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Wood
authors.forename: Michael D
authors.initials: MD
authors.lastname: Manson
authors.forename: Arul
authors.initials: A
authors.lastname: Jayaraman
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002633:Chemotaxis; D004926:Escherichia coli / Q000378:metabolism / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D006714:Homoserine / Q000031:analogs & derivatives* / Q000378:metabolism; D007783:Lactones / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D053038:Quorum Sensing
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D007783:Lactones; C555903:LsrB protein, E coli; D008565:Membrane Proteins; C091088:N-octanoylhomoserine lactone; C057635:Tsr protein, Bacteria; D006714:Homoserine