title: Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population.
abstract: OBJECTIVE
  The CIDEA gene is involved in energy metabolism and a non-synonymous single nucleotide polymorphism (SNP), V115F (G/T), is a risk factor for obesity in Swedish subjects and metabolic syndrome (MetS) in Japanese subjects. However, the risk allele was a G in Swedish subjects and a T in Japanese subjects. The present study investigated the association between this SNP and MetS in a Chinese population.
  
  
  METHODS
  Three hundred and fifty-one subjects evaluated at the Cardiac Clinic in Xuanwu Hospital for MetS risks were recruited. Anthropometric measurements, blood pressure, fasting blood glucose, and blood lipid levels were determined in addition to the polymorphism.
  
  
  RESULTS
  The proportion of subjects with MetS was significantly higher based on genotype, in the order: GG<GT<TT (p=0.003). In multiple logistic regression analysis, the odds ratios for MetS in the GT and TT genotypes, compared to the referent GG genotype, were 2.26 (p=0.003) and 2.89 (p=0.002), respectively. Similar trends were observed for the related phenotypes of central obesity (GT: OR=2.20, p=0.004; TT: OR=3.31, p=0.002) and dyslipidemia (GT: OR=1.73, p=0.047; TT: OR=2.10, p=0.03).
  
  
  CONCLUSIONS
  The T allele of the CIDEA V115F SNP is a risk factor for MetS and its related phenotypes in a Chinese population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, No. 129 Mail Box, No. 10 Xitoutiao, Youanmenwai, Beijing 100069, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Dai
authors.forename: Lili
authors.initials: L
authors.lastname: Bian
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Qi
authors.initials: Q
authors.lastname: Hua
mesh_terms: D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D051017:Apoptosis Regulatory Proteins; C502539:CIDEA protein, human