title: Nuclear receptor-driven alterations in bile acid and lipid metabolic pathways during gestation.
abstract: Nuclear receptor signalling is essential for physiological processes such as metabolism, development, and reproduction. Alterations in the endocrine state that naturally occur during pregnancy result in maternal adaptations to support the feto-placental unit. A series of studies have shown that nuclear receptor signalling is involved in maternal adaptations of bile acid, cholesterol, and lipid homeostasis pathways to ensure maintenance of the nutritional demands of the fetus. We discuss regulation of hepatic nuclear receptors and their target genes in pregnancy and their impact on the development of disorders such as intrahepatic cholestasis of pregnancy and oestrogen-induced hepatotoxicity. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
authors.affiliation: Imperial College London, Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Du Cane Road, London W12 0NN, UK.
authors.forename: Georgia
authors.initials: G
authors.lastname: Papacleovoulou
authors.forename: Shadi
authors.initials: S
authors.lastname: Abu-Hayyeh
authors.forename: Catherine
authors.initials: C
authors.lastname: Williamson
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002940:Circadian Rhythm; D004967:Estrogens / Q000502:physiology; D005260:Female; D015870:Gene Expression; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D011247:Pregnancy / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D001647:Bile Acids and Salts; D004967:Estrogens; D018160:Receptors, Cytoplasmic and Nuclear