title: Synthesis, spectral, thermal and antimicrobial studies of some new tri metallic biologically active ceftriaxone complexes.
abstract: Iron, cobalt, nickel and copper complexes of ceftriaxone were prepared in 1:3 ligand:metal ratio to examine the ligating properties of the different moieties of the drug. The complexes were found to have high percentages of coordinated water molecules. The modes of bonding were discussed depending on the infrared spectral absorption peaks of the different allowed vibrations. The Nujol mull electronic absorption spectra and the magnetic moment values indicated the Oh geometry of the metal ions in the complexes. The ESR spectra of the iron, cobalt, and copper complexes were determined and discussed. The thermal behaviors of the complexes were studied by TG and DTA techniques. The antimicrobial activities of the complexes were examined and compared to that of the ceftriaxone itself.
authors.affiliation: Chemistry Department, Faculty of Science, Alexandria University, Damanhour, Egypt. dralaae@yahoo.com
authors.forename: Alaa E
authors.initials: AE
authors.lastname: Ali
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002443:Ceftriaxone / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003035:Cobalt / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D007501:Iron / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011522:Protons; D013055:Spectrophotometry, Infrared; D055672:Static Electricity; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000890:Anti-Infective Agents; D008670:Metals; D011522:Protons; D003035:Cobalt; D002443:Ceftriaxone; D003300:Copper; D007501:Iron