title: An unusual case of anti-glomerular basement membrane disease presenting with nephrotic syndrome.
abstract: Anti-glomerular basement membrane (anti-GBM) disease is a vasculitic disease characterized by acute kidney injury, oliguria, hematuria and proteinuria. Proteinuria is rarely in the nephrotic range. A case of anti-GBM disease with proteinuria of 22.5 g/day is discussed. Immunofluorescence showed strong linear IgG deposits while electron microscopy showed widespread visceral epithelial cell foot cell process effacement. No electron dense immune complex-type deposits were identified. Pathology findings were not suggestive of simultaneous presentation of anti-GBM disease and other diseases associated with nephrotic range proteinuria. Anti-GBM disease should be considered in a comprehensive differential diagnosis of severe proteinuria.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Virginia, Box 800133, Charlottesville, VA 22908, USA.
authors.forename: Chidi C
authors.initials: CC
authors.lastname: Okafor
authors.forename: Rasheed A
authors.initials: RA
authors.lastname: Balogun
authors.forename: David T
authors.initials: DT
authors.lastname: Bourne
authors.forename: Turki O
authors.initials: TO
authors.lastname: Alhussain
authors.forename: E M
authors.initials: EM
authors.lastname: Abdel-Rahman
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006417:Hematuria / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology; D006435:Renal Dialysis