title: Metabolomics for early detection of drug-induced kidney injury: review of the current status.
abstract: The identification of biomarkers of drug-induced kidney injury is an area of intensive focus in drug development. Traditional markers of renal function, including blood urea nitrogen and serum creatinine, are not region-specific and only increase significantly after substantial kidney injury. Therefore, more sensitive markers of kidney injury are needed. The ideal biomarkers will identify nephrotoxicity early in the drug-discovery process, resulting in decreased development costs and safer drugs. Metabolomics, the study of the small biochemicals present in a biological sample, has become a promising player in the nephrotoxicity arena. In this review, we describe the current status of the identification of metabolic biomarkers for drug-induced kidney toxicity screening. Many of these markers have been confirmed across multiple studies and can detect nephrotoxicity earlier than the traditional clinical chemistry and histopathology methods. Upon further validation, such markers will offer clear benefits for the pharmaceutical industry and regulatory agencies.
authors.affiliation: Metabolon Inc., 800 Capitola Drive, Suite 1, Durham, NC 27713, USA.
authors.forename: Kurt J
authors.initials: KJ
authors.lastname: Boudonck
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Rose
authors.forename: Edward D
authors.initials: ED
authors.lastname: Karoly
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Lee
authors.forename: Kay A
authors.initials: KA
authors.lastname: Lawton
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Lapinskas
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis*; D000818:Animals; D054316:Biomarkers, Pharmacological / Q000032:analysis* / Q000378:metabolism; D015195:Drug Design; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis* / Q000378:metabolism; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D055432:Metabolomics / Q000379:methods*; D051379:Mice; D051381:Rats
chemical_list: D054316:Biomarkers, Pharmacological