title: Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas.
abstract: Brain glucose uptake was examined in transgenic mice relevant to Alzheimer's disease (APP/PS1) and their control littermates (PS1). Glucose distribution in the brain of the resting animals was measured using 3D-reconstructed autoradiography and analysed by a voxel-wise approach using SPMMouse combined to an MRI-based 3D digital atlas. Prompt and direct indexation of metabolic changes between the two groups was achieved, showing both hypo- and hypermetabolism of glucose in the brain of APP/PS1 mice. We confirm and extend previous study, since we identified brain structures affected in this pathological model and demonstrate glucose uptake changes in structures like the olfactory bulb. Our results pave the way to complete and accurate examination of functional data from cerebral structures involved in models of neurodegenerative diseases.
authors.affiliation: Medical Image Research Center (MIRCen), URA CEA-CNRS 2210, CEA-DSV-I2BM, 18 route du Panorama, F-92265 Fontenay Aux Roses Cedex, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lebenberg
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Herard
authors.forename: Albertine
authors.initials: A
authors.lastname: Dubois
authors.forename: Marc
authors.initials: M
authors.lastname: Dhenain
authors.forename: Philippe
authors.initials: P
authors.lastname: Hantraye
authors.forename: Thierry
authors.initials: T
authors.lastname: Delzescaux
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001331:Automation; D001921:Brain / Q000378:metabolism / Q000473:pathology; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008822:Mice, Transgenic; D009929:Organ Size; D053764:Presenilin-1 / Q000378:metabolism; D012984:Software
chemical_list: D016564:Amyloid beta-Protein Precursor; D053764:Presenilin-1