title: Endothelial and cardiac regeneration from adipose tissues.
abstract: For a long time, adipose tissue was only considered for its crucial role in energy balance and associated diseases. The discovery of the presence of immature cells highlights a putative role for these tissues as reservoirs of therapeutic cells. Indeed, since fat pads can be sampled by liposuction under local anesthesia in adult patients, adipose tissue represents a promising source of regenerative cells, particularly in cardiovascular regeneration. Indeed among other potentials, we and others have demonstrated the great angiogenic properties of adipose-derived stromal cells (ASCs) and the existence of peculiar cells, at least in mice, that are able to spontaneously give rise to functional cardiomyocytes. This review deciphers the different steps necessary to isolate, characterize, and manipulate such striking cells.
authors.affiliation: UPS, UMR 5241 Métabolisme, Plasticité et Mitochondrie, CNRS, Université de Toulouse, Toulouse, France. louis.casteilla@inserm.fr
authors.forename: Louis
authors.initials: L
authors.lastname: Casteilla
authors.forename: Valérie
authors.initials: V
authors.lastname: Planat-Bénard
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dehez
authors.forename: Sandra
authors.initials: S
authors.lastname: De Barros
authors.forename: Corinne
authors.initials: C
authors.lastname: Barreau
authors.forename: Mireille
authors.initials: M
authors.lastname: André
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D004727:Endothelium / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism