title: High-sensitivity troponin T as a marker of myocardial injury after radiofrequency catheter ablation.
abstract: BACKGROUND
  The aim of our study was to monitor radiofrequency catheter ablation-induced myocardial damage by measuring high-sensitivity cardiac troponin T (hs-cTnT).
  
  
  METHODS
  Serum concentrations of hs-cTnT (Elecsys 2010 system, Roche) were measured in 73 healthy blood donors and serially in 27 patients who had samples taken both before and 24 h after radiofrequency ablation (RFA) for atrioventricular nodal re-entry tachycardia (AVNRT), atrial fibrillation (AF) or right atrial flutter (AFL).
  
  
  RESULTS
  Significant increases of hs-cTnT were seen in patients after RFA (AVNRT: P = 0.0115, AF: P = 0.0011, AFL: P = 0.0009). Postprocedural serum hs-cTnT correlated with the number of radiofrequency applications and with the duration of RFA procedure. Spearman's coefficient of rank correlation (r) were as follows: hs-cTnT versus RFA duration: r = 0.771 (P < 0.001); hs-cTnT versus number of pulses: r = 0.708 (P < 0.001). Patients with the diagnosis of AVNRT had lower serum hs-cTnT concentration after RFA compared with AFL (P < 0.0001) and AF (P < 0.0001) patients.
  
  
  CONCLUSIONS
  Our data indicate that RFA causes a significant increase of serum hs-cTnT concentration that could be used to monitor myocardial injury.
authors.affiliation: Institute of Clinical Biochemistry and Diagnostics, Charles University, Faculty of Medicine, University Hospital, Hradec Kralove, Czech Republic. ulrycmar@fnhk.cz
authors.forename: M
authors.initials: M
authors.lastname: Vasatova
authors.forename: R
authors.initials: R
authors.lastname: Pudil
authors.forename: M
authors.initials: M
authors.lastname: Tichy
authors.forename: T
authors.initials: T
authors.lastname: Buchler
authors.forename: J M
authors.initials: JM
authors.lastname: Horacek
authors.forename: L
authors.initials: L
authors.lastname: Haman
authors.forename: P
authors.initials: P
authors.lastname: Parizek
authors.forename: V
authors.initials: V
authors.lastname: Palicka
mesh_terms: D001281:Atrial Fibrillation / Q000628:therapy; D001282:Atrial Flutter / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation / Q000009:adverse effects*; D005260:Female; D006335:Heart Injuries / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D009206:Myocardium; D010865:Pilot Projects; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000628:therapy; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T