title: Serum uric acid in relation with the metabolic syndrome components and adiponectin levels in Lebanese University students.
abstract: BACKGROUND
  The relation between serum uric acid (SUA) and metabolic syndrome (MetS) parameters has never been studied in a young Middle-Eastern population. In addition, the relation between SUA and adiponectin was poorly studied.
  
  
  METHODS
  We looked at the relation between SUA, and both adiponectin and MetS components in 381 randomly selected Lebanese university students (201 males and 180 females).
  
  
  RESULTS
  SUA was positively correlated with body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), fasting blood glucose (FPG), triglycerides, total and LDL-cholesterol, and homeostasis model assessment (HOMA) index (p<0.001 for all variables, p<0.01 for FPG) and inversely correlated with HDL-cholesterol and adiponectin (p<0.001 for both variables). In men, SUA was positively correlated with BMI, WC, SBP, DBP, FPG, triglycerides, total and LDL-cholesterol, and HOMA index and inversely correlated with adiponectin (p<0.001 for all variables, p<0.05 for adiponectin); these correlations persisted after BMI adjustment, for WC, FPG, triglycerides, total-cholesterol, LDL-cholesterol, and HOMA index. In women, SUA was positively correlated with total and LDL-cholesterol (p<0.001), independently of BMI. In a multiple regression analysis, SUA was independently associated with WC, triglycerides, total cholesterol, HDLcholesterol and adiponectin in the overall population while, in men, it was associated with triglycerides, total-cholesterol, and WC.
  
  
  CONCLUSIONS
  Our results suggest, in young adults, a gender difference in the relation between SUA and both adiponectin and MetS parameters. In addition, we observed in both genders a strong relation of SUA with total cholesterol. Further studies are needed in larger populations in order to elucidate these findings.
authors.affiliation: Department of Biochemistry, Saint-Joseph University, Beirut, Lebanon.
authors.forename: R
authors.initials: R
authors.lastname: Chedid
authors.forename: F
authors.initials: F
authors.lastname: Zoghbi
authors.forename: G
authors.initials: G
authors.lastname: Halaby
authors.forename: M-H
authors.initials: MH
authors.lastname: Gannagé-Yared
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007861:Lebanon; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000503:physiopathology*; D013334:Students; D014495:Universities; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008078:Cholesterol, LDL; D014527:Uric Acid; D002784:Cholesterol