title: Effects and mechanisms of tacrolimus on development of murine Th17 cells.
abstract: Tacrolimus (Tac, FK506) is a widely used T-cell-targeted immunosuppression drug known as a calcineurin inhibitor. However, its pharmacologic effects on T-helper type 17 (Th17) cells have not been fully elucidated. Herein, we demonstrate that Tac inhibits Th17 cell differentiation and proliferation, and expression of IL-17 messenger RNA. The proposed mechanism is that Tac inhibits calcineurin and T-cell receptor stimulation-induced cell division. Because Th17 cells participate in allograft rejection, the results of the present study suggest a novel model of immunosuppression effects of Tac. In addition, they provide further implications for the therapeutic immunosuppression effects of Tac on allograft rejection.
authors.affiliation: Department of Organ Transplantation, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: X-J
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Y-D
authors.initials: YD
authors.lastname: Kang
authors.forename: L
authors.initials: L
authors.lastname: Xiao
authors.forename: R-D
authors.initials: RD
authors.lastname: Li
authors.forename: G-S
authors.initials: GS
authors.lastname: Ding
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Wang
authors.forename: Z-R
authors.initials: ZR
authors.lastname: Fu
mesh_terms: D000818:Animals; D065095:Calcineurin Inhibitors; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology; D016559:Tacrolimus / Q000494:pharmacology*
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D020381:Interleukin-17; D012333:RNA, Messenger; D016559:Tacrolimus