title: Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke.
abstract: A 12-year-old boy with HbSS sickle cell disease (SCD) was admitted with an acute febrile illness and developed overt stroke 3 days later. Plasma glial fibrillary acidic protein levels were elevated, as compared to pediatric controls, 32 h prior to the clinical diagnosis of stroke, peaked immediately prior to the exchange transfusion, and remained elevated 1 year later despite chronic transfusion therapy. Stroke in SCD can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful.
authors.affiliation: Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. wsavage1@jhmi.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Savage
authors.forename: Allen D
authors.initials: AD
authors.lastname: Everett
authors.forename: James F
authors.initials: JF
authors.lastname: Casella
mesh_terms: D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D002648:Child; D005078:Exchange Transfusion, Whole Blood; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D020521:Stroke / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein