title: Destructive power dynamics of alpha-theta oscillations via spike and wave in CA3.
abstract: The power dynamics of alpha-theta oscillations via inter-ictal spikes and waves (SWs) in CA3 is investigated by means of Hilbert transform and the statistical method based on CA3 channel of LFP(Local Field Potention) data sampled on total 6 rats in resting with sniffing and of iEEG data on total 10 patients in quiet wakefulness. The comparison of alpha-theta power is done between the inter-ictal groups and control groups. It is concluded that the inter-ictal SWs can disrupt the power of alpha-theta oscillations, leading to the decreased power after SW. Because the alpha-theta oscillations are related with the cognition, it is estimated that the inter-ictal SWs can negatively affecte the cognitive function during the inter-ictal dynamics, although the alpha-theta power will be recoverable in some days after injections, even exceed over the power level before injections.
authors.affiliation: Province-Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, China. dongguoya@gmail.com
authors.forename: Guoya
authors.initials: G
authors.lastname: Dong
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chen
authors.forename: Wenwen
authors.initials: W
authors.lastname: Li
authors.forename: Zhishuang
authors.initials: Z
authors.lastname: Cheng
authors.forename: Manling
authors.initials: M
authors.lastname: Ge
mesh_terms: D000513:Alpha Rhythm; D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering / Q000379:methods; D056654:CA3 Region, Hippocampal / Q000473:pathology*; D003071:Cognition; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D015233:Models, Statistical; D018721:Muscarinic Agonists / Q000494:pharmacology; D009991:Oscillometry / Q000379:methods*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D013826:Theta Rhythm; D013997:Time Factors
chemical_list: D018721:Muscarinic Agonists; D010862:Pilocarpine