title: A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic.
abstract: OBJECTIVE
  • To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic.
  
  
  METHODS
  • We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 centres in China. • Eligible patients randomly received tamsulosin or nifedipine. Efficacies of the two agents in MET were compared at 4 weeks. • The primary endpoint was overall stone-expulsion rate. • Secondary endpoints were stone-expulsion time, rate of pain relief therapy, mean analgesic consumption for renal colic recurrence, and side-effects incidence.
  
  
  RESULTS
  • Stone-expulsion rates in the tamsulosin group (group 1) were greater than those in the nifedipine group (group 2; P < 0.01). • There was a significant variation in stone-expulsion rates and times between groups 1 and 2 (P < 0.01); with improvements in stone-expulsion rate and time significantly better in group 1 than in group 2. • There was a significant variation in the rate of pain relief therapy for renal colic recurrence between groups 1 and 2 (P < 0.01); patients in group 1 required significantly less analgesics than those in group 2 (P < 0.01). • There were no statistically significant differences in side-effects incidence between the groups.
  
  
  CONCLUSIONS
  • Administration of tamsulosin and nifedipine in MET was determined to be safe and effective for distal ureteric stones with renal colic. • Tamsulosin was significantly better than nifedipine in relieving renal colic and facilitating ureteric stone expulsion.
authors.affiliation: Urology Divisions Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Zhangqun
authors.initials: Z
authors.lastname: Ye
authors.forename: Huan
authors.initials: H
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Zhang
authors.forename: Yaoliang
authors.initials: Y
authors.lastname: Deng
authors.forename: Guohua
authors.initials: G
authors.lastname: Zeng
authors.forename: Lingwu
authors.initials: L
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Cheng
authors.forename: Jianggen
authors.initials: J
authors.lastname: Yang
authors.forename: Qiwu
authors.initials: Q
authors.lastname: Mi
authors.forename: Yonghai
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000328:Adult; D002681:China; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D056844:Renal Colic / Q000188:drug therapy* / Q000209:etiology; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D016896:Treatment Outcome; D014514:Ureteral Calculi / Q000150:complications / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin; D009543:Nifedipine