title: Photodynamic effects on basal cell carcinoma with topical Photosensitizer.
abstract: Photodynamic therapy (PDT) is a potential cancer therapy used in several clinical fields. Its application in dermatology following a fixed protocol usually generates good results. However, some cases of basal cell carcinoma show tumour persistence. The poor response observed in this type of pathology, whose lesions penetrate in the deeper layers of the skin, could be attributed to an insufficient accumulation of the PS (Photosensitizer) in deeper tissues. The development of accurate models could propose the adequate treatment dosimetry for those problematic cases in order to maximize the efficiency of the PDT treatment outcome. In this work we present a PDT model that tries to predict the photodynamic effect on the skin affected by a basal cell carcinoma with a topically administered photosensitizer. The results obtained allow us to know the evolution of the cytotoxic agent in order to estimate the necrotic area adjusting parameters such as the optical power, the photosensitizer concentration, the incubation and exposition time or the diffusivity and permeability of the damaged tissue.
authors.affiliation: Applied Optical Techniques Group, TEISA Department, University of Cantabria, Spain. isalas@teisa.unican.es
authors.forename: Irene
authors.initials: I
authors.lastname: Salas-Garcia
authors.forename: Felix
authors.initials: F
authors.lastname: Fanjul-Velez
authors.forename: Noe
authors.initials: N
authors.lastname: Ortega-Quijano
authors.forename: Jose L
authors.initials: JL
authors.lastname: Arce-Diego
mesh_terms: D000287:Administration, Topical; D002280:Basal Cell Carcinoma / Q000628:therapy*; D003880:Dermatology / Q000379:methods; D006801:Humans; D009010:Monte Carlo Method; D009336:Necrosis; D010100:Oxygen / Q000737:chemistry; D010777:Photochemistry / Q000379:methods; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011524:Protoporphyrins / Q000737:chemistry; D015203:Reproducibility of Results; D012878:Skin Neoplasms / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D011524:Protoporphyrins; C028025:protoporphyrin IX; D010100:Oxygen