title: Near full-length genomic characterization of a novel HIV type 1 CRF07_ BC/CRF08_ BC recombinant strain from Yunnan, China.
abstract: Yunnan province was considered the HIV-1 epicenter of China, where many subtypes and CRFs of HIV-1 were circulating. CRF07_BC and CRF08_BC were two of the main circulating subtypes that caused more than 90% of the HIV-1 infections in intravenous drug users (IDUs) in this district. The cocirculation of these two CRFs in the same area and population predicted the emergence of new second-generation recombinants. This study presented a near full-length genomic analysis of a novel HIV-1 recombination (09YN072) involving CRF07_BC and CRF08_BC. The analyses of the sequence of 09YN072 showed that two CRF07_BC segments were inserted into the CRF08_BC backbone. The discovery of the novel recombinant strain complicates the HIV-1 epidemic in Yunnan, China, as well as the development of effective vaccines to limit the spread of HIV-1 in China.
authors.affiliation: Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.forename: Shaomin
authors.initials: S
authors.lastname: Yang
authors.forename: Jingyun
authors.initials: J
authors.lastname: Li
authors.forename: Jianjian
authors.initials: J
authors.lastname: Li
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Liu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Bihui
authors.initials: B
authors.lastname: Yang
authors.forename: Tianyi
authors.initials: T
authors.lastname: Li
authors.forename: Hanping
authors.initials: H
authors.lastname: Li
authors.forename: Zuoyi
authors.initials: Z
authors.lastname: Bao
authors.forename: Daomin
authors.initials: D
authors.lastname: Zhuang
authors.forename: Siyang
authors.initials: S
authors.lastname: Liu
authors.forename: Lin
authors.initials: L
authors.lastname: Li
mesh_terms: D000328:Adult; D002681:China; D016000:Cluster Analysis; D016679:Genome, Viral; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral