title: Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer's disease.
abstract: Objective and early detection of Alzheimer's disease (AD) is a demanding problem requiring consideration of manymodal observations. Potentially, many features could be used to discern between people without AD and those at different stages of the disease. Such features include results from cognitive and memory tests, imaging (MRI, PET) results, cerebral spine fluid data, blood markers etc. However, in order to define an efficient and limited set of features that can be employed in classifiers requires mining of data from many patient cases. In this study we used two databases, ADNI and Kuopio LMCI, to investigate the relative importance of features and their combinations. Optimal feature combinations are to be used in a Clinical Decision Support System that is to be used in clinical AD diagnosis practice.
authors.affiliation: VTT Technical Research Centre of Finland, Tampere, Finland. mark.vangils@vtt.fi
authors.forename: Mark
authors.initials: M
authors.lastname: van Gils
authors.forename: Juha
authors.initials: J
authors.lastname: Koikkalainen
authors.forename: Jussi
authors.initials: J
authors.lastname: Mattila
authors.forename: Sannakaisa
authors.initials: S
authors.lastname: Herukka
authors.forename: Jyrki
authors.initials: J
authors.lastname: Lotjonen
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D002555:Cerebrospinal Fluid / Q000378:metabolism; D015331:Cohort Studies; D020000:Decision Support Systems, Clinical; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D001057:Apolipoproteins E; D015415:Biomarkers