title: Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes.
abstract: A new method for the synthesis of dihydroimidazo[1,2-a][1,3,5]triazin-4(6H)-ones via copper(I)-catalyzed hydroamination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)-catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
authors.forename: Larissa B
authors.initials: LB
authors.lastname: Krasnova
authors.forename: Jason E
authors.initials: JE
authors.lastname: Hein
authors.forename: Valery V
authors.initials: VV
authors.lastname: Fokin
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D007536:Isomerism; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001372:Aza Compounds; D006847:Hydrocarbons, Iodinated; D011687:Purines; C064191:1H-imidazo(4,5-b)pyridine; D003300:Copper