title: Effects of Juniperus oxycedrus ssp. oxycedrus on tissue lipid peroxidation, trace elements (Cu, Zn, Fe) and blood glucose levels in experimental diabetes.
abstract: BACKGROUND
  Juniperus oxycedrus L. (Cupressaceae) fruits and leaves are used internally and pounded fruits are eaten for diabetes in Turkey.
  
  
  OBJECTIVE
  To evaluate the interrelationships between the levels of chosen trace elements (copper, iron, and zinc) and hepatic, renal lipid peroxidation (TBARS) in streptozotocin-induced diabetic rats treated with Juniperus oxycedrus ssp. oxycedrus (J.o.s.o.) leaf and fruit extracts for 10 days.
  
  
  METHODS
  J.o.s.o. fruit and leaf extracts were administered in STZ-induced diabetic rats, at doses of 500 and 1000 mg/kg. The blood glucose levels were measured in the 1st, 4th, 7th and 10th day of experiment. Fe, Cu, and Zn contents and lipid peroxidation levels of liver and kidney tissues were determined by atomic absorption spectrophotometry and ultraviolet spectrophotometry, respectively.
  
  
  RESULTS
  Treatment of diabetic rats with the J.o.s.o. fruit and leaf extracts decreased the blood glucose levels and both the levels of lipid peroxidation in liver and kidney tissues. J.o.s.o. extracts have augmented Zn concentrations in liver of STZ-induced diabetic rats.
  
  
  CONCLUSIONS
  Results indicated that J.o.s.o. fruit and leaf extracts might be beneficial for diabetes and its complications.
authors.affiliation: Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, 06330 Etiler, Ankara, Turkey. nsendogdu@gazi.edu.tr
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Orhan
authors.forename: Aysel
authors.initials: A
authors.lastname: Berkkan
authors.forename: Didem
authors.initials: D
authors.lastname: Deliorman Orhan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aslan
authors.forename: Fatma
authors.initials: F
authors.lastname: Ergun
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D020834:Ethnopharmacology; D005638:Fruit / Q000737:chemistry; D007501:Iron / Q000378:metabolism; D018653:Juniperus / Q000737:chemistry; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014131:Trace Elements / Q000378:metabolism*; D014421:Turkey; D015032:Zinc / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D028321:Plant Preparations; D014131:Trace Elements; D003300:Copper; D007501:Iron; D015032:Zinc