title: Malignant inguinal monophasic synovial sarcoma: report of a case and review of the literature.
abstract: BACKGROUND
  A synovial sarcoma (SS) is an aggressive soft tissue tumor that classically occurs in the extremities near, but rarely within large joints, in young adults. Variable symptoms and clinical manifestations may be encountered and a definite diagnosis should depend on pathological results. This poses certain difficulties in arriving at a prompt diagnosis and appropriate treatment.
  
  
  METHODS
  We report the case of a 68-year-old woman patient who presented an inguinal mass with swelling and pain in the right lower limb. She underwent surgery, and later received systematic intravenous chemotherapy. The pathological studies, especially the specific chromosomal translocation of a t(X;18) (p11.2;q11.2), confirmed the diagnosis as a synovial sarcoma. To the best of our knowledge, this is the first report of a monophasic synovial sarcoma in the inguinal region.
  
  
  CONCLUSIONS
  Besides making the readership aware of the rarity of location and age of this present case, this report distinctly highlights the great value of a molecular analysis of an SYT associated genetic alteration in the diagnosis of synovial sarcoma occurring at rare sites especially when immunochemical results are equivocal.
authors.affiliation: Department of Surgery, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. shxhyy@yahoo.com
authors.forename: Ji
authors.initials: J
authors.lastname: Xu
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Long
authors.initials: L
authors.lastname: Cui
authors.forename: Xiangru
authors.initials: X
authors.lastname: Wu
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007264:Inguinal Canal; D007813:Laparotomy; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D014057:Tomography, X-Ray Computed; D018608:Ultrasonography, Doppler
chemical_list: D000970:Antineoplastic Agents