title: Response property of inferior collicular neurons inherited from peripheral origin in mouse.
abstract: The mechanisms underlying spike time coding in auditory system are not well understood. Despite of several models proposed to describe the first spike latency (FSL), there is no comparison of their respective performance. Here, based on FSL data from the central nucleus of inferior colliculus (CIC) in mouse to tone stimuli with varying rise function, rise time, and amplitude, we examined the previous models by comparing the recorded FSL with derived the FSL, respectively. We found that the LIEFTS (leaky integration, event formation, temporal summation) threshold model produced better match with the recorded data than other models. In addition, the model suggested that the short time constants derived from the FSL data (<2 ms) cannot be attributed to IC neurons themselves (normally longer than 10 ms), but are similar to those for the inner hair cells (around 1.4 ms). Our results suggested that LIEFTS threshold model is a better fit for FSL, and FSL properties in central neurons can be inherited along the central auditory pathway, likely through faithful relays from the peripheral origins.
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
authors.forename: Feixue
authors.initials: F
authors.lastname: Liang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Yang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zheng
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Tan
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhongju
authors.initials: Z
authors.lastname: Xiao
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D005260:Female; D007245:Inferior Colliculi / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted