title: Late-onset intestinal perforation in the setting of posttransplantation microangiopathy: a case report.
abstract: Intestinal perforation in the setting of posttransplantation microangiopathy (TMA) is a very rare event and might be considered a terminal event of intestinal microangiopathy (i-TMA), a rather rarely recognized posttransplantation complication, as it overlaps with the more common intestinal graft-versus-host disease (GVHD). Cases of i-TMA described in literature occurred within with first 100 days posttransplantation or shortly thereafter. In this report, we describe a case of late-onset intestinal perforation that occurred in the setting of systemic microangiopathy more than a year after allogeneic transplantation. In our case, the patient poorly responded to treatment secondary to refractory mircoangiopathy.
authors.affiliation: Division of Hematology, Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: O S
authors.initials: OS
authors.lastname: Aljitawi
authors.forename: L
authors.initials: L
authors.lastname: Rodriguez
authors.forename: R
authors.initials: R
authors.lastname: Madan
authors.forename: S
authors.initials: S
authors.lastname: Ganguly
authors.forename: S
authors.initials: S
authors.lastname: Abhyankar
authors.forename: J P
authors.initials: JP
authors.lastname: McGuirk
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D003082:Colectomy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007416:Intestinal Perforation / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D007422:Intestines / Q000637:transplantation*; D007511:Ischemia / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D010956:Plasmapheresis; D000069283:Rituximab; D057049:Thrombotic Microangiopathies / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab