title: [Focusing properties of picosecond electric pulses in non-invasive cancer treatment].
abstract: In the light of optical theory, we advanc an ultra-wideband impulse radiating antenna (IRA) which is composed of an ellipsoidal reflector and a cone radiator. The high-intensity ultra-short electric pulses radiated by IRA can be transferred into the deep target in tissue non-invasively and be focused effectively. With the focused picosecond electric pulses, the organelles (mitochondria) transmembrane potential shall change to collapse under which the tumor cells will be targetly induced to apoptosis, so the method of non-invasive treatment of tumors would be achieved. Based on the time-domain electromagnetic field theory, the propagation characteristics of picosecond electric pulses were analyzed with and without the context of biological tissue, respectively. The results show that the impulse characteristics of input pulse were maintained and the picosecond electric pulses can keep high resolution in target areas. Meanwhile, because of the dispersive nature of medium, the pulse amplitude of the pulses will attenuate and the pulse width will be broadened.
authors.affiliation: State Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing University, Chongqing 400044, China. longzaiquan@foxmail.com
authors.forename: Zaiquan
authors.initials: Z
authors.lastname: Long
authors.forename: Chenguo
authors.initials: C
authors.lastname: Yao
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Mi
authors.forename: Caixin
authors.initials: C
authors.lastname: Sun
mesh_terms: D017209:Apoptosis / Q000528:radiation effects*; D004599:Electric Stimulation Therapy / Q000379:methods*; D004566:Electrodes; D055590:Electromagnetic Phenomena; D018274:Electroporation / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*