title: Patterns of relapse following definitive treatment of head and neck squamous cell cancer by intensity modulated radiotherapy and weekly cisplatin.
abstract: Eighty-three patients with oropharyngeal, hypopharyngeal or laryngeal cancer were treated with concomitant cisplatin 40 mg/m(2) once a week during the radiotherapy and IMRT up to a total dose of 70 Gy. The 2-year rate of local control, overall survival and disease specific survival were 84%, 82% and 89%, respectively. The corresponding 5-year Kaplan-Meier estimates were 79%, 69% and 76%.
authors.affiliation: Department of Oncology, Helsinki University Central Hospital, Finland.
authors.forename: Venla
authors.initials: V
authors.lastname: Loimu
authors.forename: Juhani
authors.initials: J
authors.lastname: Collan
authors.forename: Leila
authors.initials: L
authors.lastname: Vaalavirta
authors.forename: Leif
authors.initials: L
authors.lastname: Bäck
authors.forename: Mika
authors.initials: M
authors.lastname: Kapanen
authors.forename: Antti
authors.initials: A
authors.lastname: Mäkitie
authors.forename: Mikko
authors.initials: M
authors.lastname: Tenhunen
authors.forename: Kauko
authors.initials: K
authors.lastname: Saarilahti
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002277:Carcinoma / Q000401:mortality / Q000628:therapy; D002294:Carcinoma, Squamous Cell; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000401:mortality / Q000628:therapy; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin