title: Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population.
abstract: OBJECTIVE
  Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in oocyte maturation, embryo implantation and placenta maintenance in early gestation. This study was set out to investigate the association between polymorphisms of the progesterone receptor (PGR) gene and idiopathic RPL.
  
  
  METHODS
  One hundred twenty-one women with a history of idiopathic recurrent pregnancy loss (RPL) and 179 control subjects were enrolled into the study. Six tag SNPs and two functional SNPs [PROGINS (rs1042838), +331 C/T (rs10895068)] of the progesterone receptor gene were genotyped.
  
  
  RESULTS
  We found that the allele and genotype frequencies of the functional SNP [PROGINS (rs1042838)] were both significantly higher in patients with idiopathic RPL than in the control subjects (both P values = 0.006). In addition, the C-C haplotype, which consists of rs590688C > G and rs11224592T > C, is associated with a decreased risk of RPL (p = 0.004).
  
  
  CONCLUSIONS
  PROGINS polymorphism confers susceptibility to idiopathic recurrent pregnancy loss in Taiwanese Han women.
authors.affiliation: Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan, Taiwan.
authors.forename: Mei-Tsz
authors.initials: MT
authors.lastname: Su
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Lee
authors.forename: Yi-Chi
authors.initials: YC
authors.lastname: Chen
authors.forename: Pao-Lin
authors.initials: PL
authors.lastname: Kuo
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006239:Haplotypes; D006801:Humans; D008183:Luteal Phase / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000235:genetics*; D013624:Taiwan
chemical_list: D011980:Receptors, Progesterone