title: [Efficiency of emoxipine in treatment of multiple organ failure in newborns].
abstract: Prospective, placebo-controlled, simple "blind" randomized study of the effect of emoxipine (2-ethyl-6-methyl-3-oxypyridine hydrochloride) on the dynamics of central hemodynamics, content of lipid peroxidation products in tracheo-bronchial lavage, and severity of clinical sickness was performed in newborn children with multiple organ failures (MOF). The obtained results showed that a 10-day course of the intravenous administration of emoxipine in a single dose of 10 mg/kg improved the systolic function of myocardium of left ventricle, limited lipid peroxidation in broncho-pulmonary system, and increased oxygen delivery to tissues. These effects of emoxipine were accompanied by a clinically significant improvement of neurological status, reduction of the need for artificial ventilation of lungs, and decrease of mortality in newborns with MOF diagnosis.
authors.forename: I A
authors.initials: IA
authors.lastname: Volchegorskiĭ
authors.forename: P I
authors.initials: PI
authors.lastname: Minochkin
authors.forename: D K
authors.initials: DK
authors.lastname: Volosnikov
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D007275:Injections, Intravenous; D015931:Intensive Care, Neonatal; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood / Q000188:drug therapy* / Q000628:therapy; D010101:Oxygen Consumption / Q000187:drug effects; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D008054:Lipid Peroxides; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine