title: Pathological changes caused by Anoplocephala perfoliata in the mucosa/submucosa and in the enteric nervous system of equine ileocecal junction.
abstract: In this study, pathological changes caused by Anoplocephala perfoliata in the ileocecal junction were investigated in 31 regularly slaughtered mixed-breed horses of both sexes. Our results showed a significant relationship between parasite burden and grading of histopathological lesions in the mucosa and submucosa. Hypertrophy of the circular muscle layer was found in infected horses. Moreover, enteric nervous system evaluation showed a significant injury of intestinal nervous elements in the horses with moderate to high parasitism expressed as an increase of degenerative-regressive changes in neuronal cells and a decrease in the number of myenteric ganglia and neuronal cells. These findings can help to clarify the pathogenesis of intestinal motility disorders associated with A. perfoliata infection in horses.
authors.affiliation: Department of Biopathological Science and Hygiene of Animal and Food Productions, Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy. pavone.silvia@libero.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Pavone
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Veronesi
authors.forename: Claudio
authors.initials: C
authors.lastname: Genchi
authors.forename: Daniela Piergili
authors.initials: DP
authors.lastname: Fioretti
authors.forename: Emanuele
authors.initials: E
authors.lastname: Brianti
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Mandara
mesh_terms: D000818:Animals; D002432:Cecum / Q000294:innervation / Q000473:pathology; D002589:Cestoda / Q000145:classification; D002590:Cestode Infections / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000469:parasitology / Q000473:pathology*; D006736:Horses; D007082:Ileum / Q000294:innervation / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male