title: A 64-channel readout ASIC for nanowire biosensor array with electrical calibration scheme.
abstract: A 1.8-mW, 18.5-mm(2) 64-channel current readout ASIC was implemented in 0.18-µm CMOS together with a new calibration scheme for silicon nanowire biosensor arrays. The ASIC consists of 64 channels of dedicated readout and conditioning circuits which incorporate correlated double sampling scheme to reduce the effect of 1/f noise and offset from the analog front-end. The ASIC provides a 10-bit digital output with a sampling rate of 300 S/s whilst achieving a minimum resolution of 7 pA(rms). A new electrical calibration method was introduced to mitigate the issue of large variations in the nano-scale sensor device parameters and optimize the sensor sensitivity. The experimental results show that the proposed calibration technique improved the sensitivity by 2 to 10 times and reduced the variation between dataset by 9 times.
authors.affiliation: Integrated Circuits and Systems Laboratory, Institute of Microelectronics, A*STAR (Agency of Science, Technology and Research), Singapore. chaitc@ime.a-star.edu.sg
authors.forename: Kevin T C
authors.initials: KT
authors.lastname: Chai
authors.forename: Kunil
authors.initials: K
authors.lastname: Choe
authors.forename: Olivier D
authors.initials: OD
authors.lastname: Bernal
authors.forename: Pradeep K
authors.initials: PK
authors.lastname: Gopalakrishnan
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Zhang
authors.forename: Tae Goo
authors.initials: TG
authors.lastname: Kang
authors.forename: Minkyu
authors.initials: M
authors.lastname: Je
mesh_terms: D000703:Analog-Digital Conversion; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000592:standards; D002138:Calibration; D003217:Conductometry / Q000295:instrumentation* / Q000592:standards; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046228:Microarray Analysis / Q000295:instrumentation* / Q000592:standards; D043942:Nanotubes / Q000737:chemistry*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*