title: Global fibrinolytic capacity in neonatal sepsis.
abstract: In this study, we studied global fibrinolytic capacity (GFC) in newborn infants with sepsis. Sixty-one newborn infants, admitted to neonatal intensive care unit at Yuzuncu Yil University Hospital were enrolled in this study. White blood cell count, immature (I) / mature (M) neutrophil ratios, prothrombin time, and d-dimer levels were significantly higher in patient group than those of control group (P < .05). We found GFC to be significantly lower in the patient group compared to the control group (P < .05). The GFC value was negatively correlated to the Tollner scores but this correlation was not statistically significant (r = -.267, P = .095). Our findings showed that GFC decreases in severe neonatal sepsis; therefore, we suggest that GFC may be used for prognosis or in the early prediction of severe sepsis rather than the diagnosis of neonatal sepsis.
authors.affiliation: Department of Pediatrics, Yuzuncu Yil University School of Medicine, Van, Turkey. pekererdal@hotmail.com
authors.forename: Erdal
authors.initials: E
authors.lastname: Peker
authors.forename: Sinan
authors.initials: S
authors.lastname: Akbayram
authors.forename: Hadi
authors.initials: H
authors.lastname: Geylani
authors.forename: Murat
authors.initials: M
authors.lastname: Dogan
authors.forename: Ercan
authors.initials: E
authors.lastname: Kirimi
mesh_terms: D001780:Blood Coagulation Tests; D016022:Case-Control Studies; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis