title: Chiral determination of antidepressant drugs and their metabolites in biological samples.
abstract: The determination of chiral drugs and their metabolites in biological samples is key to gaining a full understanding of enantioselective drug action and disposition, as well as establishing the advantages of using racemate or isolated enantiomers. In this review, methods published in the last 8 years regarding the analysis of chiral antidepressant drugs and their metabolites in biological fluids (e.g., plasma, urine and cerebrospinal fluid) are reviewed. The importance and interest in analyzing the enantiomers of the active compound and its metabolites in biological samples are also discussed.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP. Av. Café SN, CEP 14040-903, Ribeirão Preto, SP, Brazil. psbonato@fcfrp.usp.br
authors.forename: Fernando José
authors.initials: FJ
authors.lastname: Malagueño de Santana
authors.forename: Valquíria Aparecida Polisel
authors.initials: VA
authors.lastname: Jabor
authors.forename: Pierina Sueli
authors.initials: PS
authors.lastname: Bonato
mesh_terms: D053000:Analytic Sample Preparation Methods; D000928:Antidepressive Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D001682:Biological Availability; D001826:Body Fluids / Q000737:chemistry*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D006801:Humans; D013237:Stereoisomerism; D013810:Therapeutic Equivalency
chemical_list: D000928:Antidepressive Agents