title: Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change.
abstract: In our extended Guyton's model, the ability of heart to pump blood is characterized by a cardiac output curve and the ability of vasculature to pool blood by a venous return surface. These intersect in a three-dimensional coordinate system at the operating right atrial pressure, left atrial pressure, and cardiac output. The baseline cardiac output curve and venous return surface and their changes after volume change would predict new hemodynamics. The invasive methods needed to precisely characterize cardiac output curve and venous return surface led us to aim at estimating cardiac output curve and venous return surface from a single hemodynamic measurement. Using the average values for two logarithmic function parameters, and for two slopes of a surface, we were able to estimate cardiac output curve and venous return surface. The estimated curve and surface predicted new hemodynamics after volume change precisely.
authors.affiliation: National Cardiovascular Center Research Institute, Suita, Osaka 5658565, Japan. su91mach@ri.ncvc.go.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Sugimachi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
authors.forename: Kazunori
authors.initials: K
authors.lastname: Uemura
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kamiya
authors.forename: Shuji
authors.initials: S
authors.lastname: Shimizu
authors.forename: Masashi
authors.initials: M
authors.lastname: Inagaki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shishido
mesh_terms: D000818:Animals; D016275:Atrial Function / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology*; D004285:Dogs; D008955:Models, Cardiovascular; D013499:Surface Properties; D014680:Veins / Q000502:physiology*