title: Outcome of lung transplantation in elderly recipients.
abstract: OBJECTIVE
  Lung transplantation is a standard treatment option for patients with end-stage lung disease. Lung transplantation in the elderly is controversial due to concerns over anticipated increased surgical risks, inferior long-term outcomes and proper stewardship in allocating limited donor organs. With demographic trends showing an increasing proportion of patients over 60 years old, we evaluated our outcomes with lung transplantation in this older cohort.
  
  
  METHODS
  Between January 1990 and July 2009, 142 patients underwent lung transplantation at our institution. A total of 15 patients receiving heart/lung transplantation and one patient declining research participation were excluded. As many as 126 patients were analyzed in two groups: <60 and ≥ 60 years old.
  
  
  RESULTS
  There were 65 females (52%) and 61 males (48%). A total of 53 patients (42%) underwent bilateral sequential lung transplantation and 73 patients single-lung transplantation (58%). Median age at transplantation was 55.3 years (range, 21.6-73.1 years) with 94 patients <60 years (75%) and 32 patients ≥ 60 years (25%). Median follow-up was 4.3 years (range, 0-17.8 years). Overall survival at 30 days was 93.7% with no difference between age groups (p=0.95). There was no difference between the groups for in-hospital, postoperative complications (p=0.86), or unplanned readmission rates within 90 days of the hospitalization (p=0.26). Postoperative pulmonary function (forced expiratory volume in 1s (FEV1) % predicted) at transplant, 4 weeks, 3 months, and 6 months after transplantation was not different between groups (p=0.93). No difference in long-term survival was observed (p=0.59), with 5-year survival of 52.2% for patients <60 years and 47.3% for patients ≥ 60 years. Overall, 20 patients developed bronchiolitis obliterans syndrome and 13 posttransplant lymphoproliferative disease, which was not statistically different between age groups (p=0.87, p=0.37, respectively).
  
  
  CONCLUSIONS
  Increased age of 60 years and greater, in highly selected patients, does not appear to have a significant impact on the short- or long-term outcome in patients undergoing lung transplantation. Judicious selection of older patients, who are otherwise excellent candidates for lung transplantation, remains a reasonable option.
authors.affiliation: William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Tomaszek
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Fibla
authors.forename: Ross A
authors.initials: RA
authors.lastname: Dierkhising
authors.forename: John P
authors.initials: JP
authors.lastname: Scott
authors.forename: Keh-Hsien R
authors.initials: KR
authors.lastname: Shen
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Wigle
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Cassivi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001989:Bronchiolitis Obliterans / Q000209:etiology; D003404:Creatinine / Q000097:blood; D005541:Forced Expiratory Volume / Q000502:physiology; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000502:physiology; D008171:Lung Diseases / Q000601:surgery*; D016040:Lung Transplantation / Q000009:adverse effects / Q000502:physiology; D008875:Middle Aged; D018579:Patient Selection; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003404:Creatinine