title: Dose-Dense Chemotherapy: Principles, Clinical Results and Future Perspectives.
abstract: The dose intensity of adjuvant chemotherapy for breast cancer is an important predictor of clinical outcome. Dose-dense chemotherapy increases the dose intensity of the regimen by delivering standard-dose chemotherapy with shorter intervals between the treatment cycles. The rationale for dose-dense therapy stems from the Norton-Simon hypothesis: Sequential, consecutive dosing of chemotherapy using single or a combination of agents increases the dose density over alternating dosing, improving results. Supporting adjuvant studies, such as C9741, and the ensuing clinical experience indicate an improved disease-free and overall survival. Dosedense adjuvant chemotherapy improves clinical outcomes without increasing toxicity.
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Marc L
authors.initials: ML
authors.lastname: Citron