title: One year follow-up of the multi-centre European PARTNER transcatheter heart valve study.
abstract: BACKGROUND
  Transcatheter aortic valve implantation (TAVI) has emerged as a new therapeutic option in high-risk patients with severe aortic stenosis.
  
  
  OBJECTIVE
  PARTNER EU is the first study to evaluate prospectively the procedural and mid-term outcomes of transfemoral (TF) or transapical (TA) implantation of the Edwards SAPIEN® valve involving a multi-disciplinary approach.
  
  
  RESULTS
  Primary safety endpoints were 30 days and 6 months mortality. Primary efficacy endpoints were haemodynamic and functional improvement at 12 months. One hundred and thirty patients (61 TF, 69 TA), aged 82.1 ± 5.5 years were included. TA patients had higher logistic EuroSCORE (33.8 vs. 25.7%, P = 0.0005) and more peripheral disease (49.3 vs. 16.4%, P< 0.0001). Procedures were aborted in four TA (5.8%) and six TF cases (9.8%). Valve implantation was successful in the remaining patients in 95.4 and 96.4%, respectively. Thirty days and 6 months survival were 81.2 and 58.0% (TA) and 91.8 and 90.2% (TF). In both groups, mean aortic gradient decreased from 46.9 ± 18.1 to 10.9 ± 5.4 mmHg 6 months post-TAVI. In total, 78.1 and 84.8% of patients experienced significant improvement in New York Heart Association (NYHA) class, whereas 73.9 and 72.7% had improved Kansas City Cardiomyopathy Questionnaire (KCCQ) scores in TA and TF cohorts, respectively.
  
  
  CONCLUSIONS
  This first team-based multi-centre European TAVI registry shows promising results in high-risk patients treated by TF or TA delivery. Survival rates differ significantly between TF and TA groups and probably reflect the higher risk profile of the TA cohort. Optimal patient screening, approach selection, and device refinement may improve outcomes.
authors.affiliation: Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, Massy, France. t.lefevre@icps.com.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Lefèvre
authors.forename: Ari Pieter
authors.initials: AP
authors.lastname: Kappetein
authors.forename: Ernst
authors.initials: E
authors.lastname: Wolner
authors.forename: Patrick
authors.initials: P
authors.lastname: Nataf
authors.forename: Martyn
authors.initials: M
authors.lastname: Thomas
authors.forename: Volker
authors.initials: V
authors.lastname: Schächinger
authors.forename: Bernard
authors.initials: B
authors.lastname: De Bruyne
authors.forename: Hélène
authors.initials: H
authors.lastname: Eltchaninoff
authors.forename: Matthias
authors.initials: M
authors.lastname: Thielmann
authors.forename: Dominique
authors.initials: D
authors.lastname: Himbert
authors.forename: Mauro
authors.initials: M
authors.lastname: Romano
authors.forename: Patrick
authors.initials: P
authors.lastname: Serruys
authors.forename: Gerhard
authors.initials: G
authors.lastname: Wimmer-Greinecker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods* / Q000401:mortality; D002423:Cause of Death; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome