title: Body mass interacts with fat quality to determine the postprandial lipoprotein response in healthy young adults.
abstract: OBJECTIVE
  Postprandial lipemia predicts the evolution of cardiovascular disease. Obesity is associated with an increase in the magnitude of postprandial lipemia. Our objective was to evaluate the influence of body mass index (BMI) on the effects of acute ingestion of different types of fat on the postprandial lipemic response.
  
  
  RESULTS
  Twenty-one healthy men followed a 4-week baseline diet and then consumed three fat-loaded meals that included 1g fat/kg body wt (65%fat) according to a randomized crossover design. The compositions of the three meals were olive oil meal (22% saturated fatty acids (SFA), 38% monounsaturated fatty acids (MUFA), 4% polyunsaturated fatty acids (PUFA)); butter meal (35% SFA, 22% MUFA, 4% PUFA); walnuts meal (20% SFA, 24% MUFA, 16% PUFA, and 4% α-linolenic acid). Higher-weight (HW) subjects (BMI greater than the median 26.18 kg/m(2), n = 11) presented higher incremental area under the curve (iAUC) for triglycerides (TG), both in large- and small-TG rich lipoproteins (TRL) than lower-weight (LW) subjects (BMI<26.18 kg/m(2), n = 10) (p<0.05), and a similar trend for plasma TG (p = 0.084). Moreover, HW subjects presented higher concentrations for small TRL-cholesterol and small TRL-TG in different timepoints of the postprandial lipemia after the intake of enriched walnuts or butter meals compared with the olive oil-enriched meal (p < 0.05) No significant differences were observed between the three types of meals in the postprandial response of LW subjects.
  
  
  CONCLUSIONS
  HW subjects present a greater postprandial response than LW subjects, and they benefit from the consumption of monounsaturated fatty acids from olive oil, to lower their levels of TRL particles during the postprandial state.
authors.affiliation: Lipids and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía, Universidad de Córdoba and CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Córdoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lozano
authors.forename: P
authors.initials: P
authors.lastname: Perez-Martinez
authors.forename: J
authors.initials: J
authors.lastname: Delgado-Lista
authors.forename: C
authors.initials: C
authors.lastname: Marin
authors.forename: B
authors.initials: B
authors.lastname: Cortes
authors.forename: F
authors.initials: F
authors.lastname: Rodriguez-Cantalejo
authors.forename: M J
authors.initials: MJ
authors.lastname: Gomez-Luna
authors.forename: C
authors.initials: C
authors.lastname: Cruz-Teno
authors.forename: F
authors.initials: F
authors.lastname: Perez-Jimenez
authors.forename: J
authors.initials: J
authors.lastname: Lopez-Miranda
mesh_terms: D000293:Adolescent; D000328:Adult; D053299:Apolipoprotein B-100 / Q000097:blood; D015992:Body Mass Index; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D053299:Apolipoprotein B-100; D004041:Dietary Fats; D008074:Lipoproteins; D014280:Triglycerides