title: rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
abstract: The first allele of a 16S rRNA methyltransferase gene, rmtD2, conferring very high resistance to all clinically available aminoglycosides, was detected in 7/1,064 enterobacteria collected in 2007. rmtD2 was located on a conjugative plasmid in a Tn2670-like element inside a structure similar to that of rmtD1 but probably having an independent assembly. rmtD2 has been found since 1996 to 1998 mainly in Enterobacter and Citrobacter isolates, suggesting a possible reservoir in these genera. This presumption deserves monitoring by continuous surveillance.
authors.affiliation: Ontario Agency for Health Protection and Promotion, Public Health Laboratory, Toronto, ON, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tijet
authors.forename: Patricia
authors.initials: P
authors.lastname: Andres
authors.forename: Catherine
authors.initials: C
authors.lastname: Chung
authors.forename: Celeste
authors.initials: C
authors.lastname: Lucero
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
authors.forename: Marcelo
authors.initials: M
authors.lastname: Galas
authors.forename: Alejandra
authors.initials: A
authors.lastname: Corso
authors.forename: Alejandro
authors.initials: A
authors.lastname: Petroni
authors.forename: Roberto G
authors.initials: RG
authors.lastname: Melano
mesh_terms: D000483:Alleles; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001118:Argentina / Q000453:epidemiology; D003227:Conjugation, Genetic; D004251:DNA Transposable Elements / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013997:Time Factors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D012336:RNA, Ribosomal, 16S; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase