title: Three-dimension structure of ventricular myocardial fibers after myocardial infarction.
abstract: BACKGROUND
  To explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart.
  
  
  METHODS
  Fourteen acute anterior myocardial infarction models were made from healthy dogs (mean weight 17.6 ± 2.5 kg). Six out of 14 dogs with old myocardial infarction were sacrificed, and their hearts were harvested after they survived the acute anterior myocardial infarction for 3 months. Each heart was dissected into ventricular myocardial band (VMB), morphological characters in infarction region were observed, and infarct size percents in descending segment and ascending segment were calculated.
  
  
  RESULTS
  Six dog hearts were successfully dissected into VMB. Uncorresponding damages in myocardial fibers of descending segment and ascending segment were found in apical circle in anterior wall infarction. Infarct size percent in the ascending segment was significantly larger than that in the descending segment (23.36 ± 3.15 (SD) vs 30.69 ± 2.40%, P = 0.0033); the long axis of infarction area was perpendicular to the orientation of myocardial fibers in ascending segment; however, the long axis of the infarction area was parallel with the orientation of myocardial fibers in descending segment.
  
  
  CONCLUSIONS
  We found that damages were different in both morphology and size in ascending segment and descending segment in heart with myocardial infarction. This may provide an important insight for us to understand the mechanism of heart failure following coronary artery diseases.
authors.affiliation: Department of Cardiovascular Surgery, PLA General Hospital, 28 Fuxing Road, Beijing 100853, PR China. gaochq301@yahoo.com
authors.forename: Changqing
authors.initials: C
authors.lastname: Gao
authors.forename: Weihua
authors.initials: W
authors.lastname: Ye
authors.forename: Libin
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D056988:Anterior Wall Myocardial Infarction / Q000473:pathology*; D004285:Dogs; D006352:Heart Ventricles / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D020257:Ventricular Remodeling