title: Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue.
abstract: 2'-Deoxy-2'-fluoro-2'-C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication.
authors.affiliation: Department of Chemistry, Zhengzhou University, Zhengzhou, Henan Province, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Hu
authors.forename: Ping'an
authors.initials: P
authors.lastname: Wang
authors.forename: Chuanjun
authors.initials: C
authors.lastname: Song
authors.forename: Zhenliang
authors.initials: Z
authors.lastname: Pan
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Guo
authors.forename: Xuejun
authors.initials: X
authors.lastname: Yu
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Shen
authors.forename: Shuyang
authors.initials: S
authors.lastname: Wang
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012367:RNA, Viral / Q000187:drug effects / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase