title: The effect of the acute submaximal exercise on thrombin activatable fibrinolysis inhibitor levels in young sedentary males.
abstract: Depending on type, duration, and intensity of the exercise, changes occur in hemostasis. In this study, we evaluated the changes in the parameters of coagulation and fibrinolytic systems that happened after the submaximal aerobic exercises by bicycle ergomater. Twelve healthy male participants whose ages were between 21 and 28 have been included. The venous samples have been drawn before the exercise as well as at the 0 th, 15th, and 60th minutes after the submaximal exercise. The values of prothrombin time (PT), active partial thromboplastin time (aPTT), D-dimer, fibrinogen, plasminogen activator inhibitor 1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) have been measured. Plasminogen activator inhibitor 1 values have shown an insignificant increase after exercise (P = .328), whereas, it has decreased significantly during the resting period (P = .033) Postexercise 15th and 60th minutes TAFI values have decreased significantly comparing to basal and postexercise (0 th minute) values (P = .001). Fibrinolytic system activation is observed after acute submaximal aerobic exercise of sedentary healthy participants.
authors.affiliation: Department of Internal Medicine, Division of Hematology, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Kahraman
authors.forename: Cem S
authors.initials: CS
authors.lastname: Bediz
authors.forename: Ozden
authors.initials: O
authors.lastname: Pişkin
authors.forename: Ilkay
authors.initials: I
authors.lastname: Aksu
authors.forename: Ayça
authors.initials: A
authors.lastname: Topçu
authors.forename: Faize
authors.initials: F
authors.lastname: Yüksel
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirkan
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D025901:Carboxypeptidase B2 / Q000097:blood* / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D057185:Sedentary Behavior; D055815:Young Adult
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; C036309:fibrin fragment D; D005340:Fibrinogen; D025901:Carboxypeptidase B2