title: Relationship between mean platelet volume levels and subclinical target organ damage in newly diagnosed hypertensive patients.
abstract: BACKGROUND
  Significant numbers of asymptomatic hypertensive patients are attacked by subclinical target organ damage (TOD) such as proteinuria, left ventricular hypertrophy and carotid atherosclerosis. Platelets become activated in uncontrolled hypertension and play a crucial role in increased thrombotic tendency. Mean platelet volume (MPV) is one of the markers that correlate closely with platelet activity. We aimed to investigate the relationship between MPV levels and subclinical TOD in newly diagnosed hypertensive patients.
  
  
  METHODS
  80 newly diagnosed hypertensive patients were enrolled to this cross-sectional study. Ambulatory blood pressure monitoring was performed for all patients. Left ventricular mass index (LVMI), carotid intima-media thickness (IMT) and urine albumin/creatinine ratio (UACR) were measured as indices of cardiac, vascular and renal damage, respectively. MPV was measured from blood samples collected in EDTA tubes and high-sensitivity C reactive protein (hs-CRP) was measured by using nephlometer.
  
  
  RESULTS
  MPV was significantly correlated with 24-h systolic-diastolic blood pressure (r = 0.52 and r = 0.55, respectively). Correlation analysis indicated that MPV was moderately related with UACR, LVMI, carotid IMT and hs-CRP (r = 0.50, r = 0.55, r = 0.60 and r = 0.69, respectively, p = 0.0001). Multivariable analysis identified that MPV levels were independently associated with severity of proteinuria, carotid IMT and LVMI (p = 0.001).
  
  
  CONCLUSIONS
  Our findings suggested that MPV levels were associated with severity of subclinical TOD including; carotid atherosclerosis, left ventricular hypertrophy and renal damage, in hypertensive patients. In addition to this, MPV levels were significantly correlated with hs-CRP levels and 24-h ambulatory blood pressure measurements.
authors.affiliation: Erciyes University, School of Medicine, Department of Cardiology, Kayseri, Turkey.
authors.forename: Mikail
authors.initials: M
authors.lastname: Yarlioglues
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
authors.forename: Idris
authors.initials: I
authors.lastname: Ardic
authors.forename: Orhan
authors.initials: O
authors.lastname: Dogdu
authors.forename: Haci Ahmet
authors.initials: HA
authors.lastname: Kasapkara
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Gunturk
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.forename: Nihat
authors.initials: N
authors.lastname: Kalay
authors.forename: Ali
authors.initials: A
authors.lastname: Dogan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozdogru
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Oguzhan
mesh_terms: D000419:Albuminuria / Q000209:etiology* / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000209:etiology; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D017539:Tunica Intima / Q000473:pathology
chemical_list: D002097:C-Reactive Protein; D003404:Creatinine