title: Disease profile of children under 5 years attending primary health care clinics in a high HIV prevalence setting in South Africa.
abstract: OBJECTIVE
  To describe the presenting complaints and disease profile of children attending primary health care (PHC) clinics in two provinces of South Africa.
  
  
  METHODS
  Participants were sick children 2-59 months old presenting for care at PHC clinics in KwaZulu-Natal (KZN) and Limpopo provinces from 2006-2007. Children were assessed by an expert Integrated Management of Childhood Illnesses (IMCI) practitioner. Children for whom parental/guardian consent was obtained were tested for HIV.
  
  
  RESULTS
  A total of 1357 children attending one of 74 clinics were assessed. HIV seroprevalence overall was 7.1%, but was significantly higher in KZN than Limpopo (7.5 vs. 2.4%; OR = 3.3, 95%CI 1.9-5.8%). Commonest presenting complaints were cough (72%), skin conditions (22%) and diarrhoea (19%). Of 1349 children, 120 (8.9%) had a weight below the third percentile; 108/1357 (8.0%) children required urgent referral, most commonly for severe pneumonia (53.7%) and severe malnutrition (16.7%). In multivariate analyses, severe pneumonia, growth faltering and urgent referral were independently associated with younger age, residence in KZN and HIV infection (P < 0.05).
  
  
  CONCLUSIONS
  Many children with severe illnesses and undiagnosed HIV infection present to PHC facilities. PHC staff require skills to correctly manage these conditions and undertake HIV testing. Although IMCI provides evidence-based guidelines, implementation must be improved to achieve adequate coverage of life-saving interventions.
authors.affiliation: Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. christiane@telkomsa.net
authors.forename: Christiane
authors.initials: C
authors.lastname: Horwood
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Butler
authors.forename: Kerry
authors.initials: K
authors.lastname: Vermaak
authors.forename: Nigel
authors.initials: N
authors.lastname: Rollins
authors.forename: Lyn
authors.initials: L
authors.lastname: Haskins
authors.forename: Phumla
authors.initials: P
authors.lastname: Nkosi
authors.forename: Torsten B
authors.initials: TB
authors.lastname: Neilands
authors.forename: Shamim
authors.initials: S
authors.lastname: Qazi
mesh_terms: D002662:Child Health Services / Q000706:statistics & numerical data; D002675:Child, Preschool; D003371:Cough / Q000453:epidemiology; D019033:Delivery of Health Care, Integrated / Q000706:statistics & numerical data; D003967:Diarrhea / Q000453:epidemiology; D004630:Emergencies; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D009752:Nutritional Status; D015995:Prevalence; D011320:Primary Health Care / Q000706:statistics & numerical data*; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012120:Respiration Disorders / Q000453:epidemiology; D013019:South Africa / Q000453:epidemiology