title: Evaluation on the toxicity of ionic liquid mixture with antagonism and synergism to Vibrio qinghaiensis sp.-Q67.
abstract: Ionic liquids (ILs) are a fascinating group of new chemicals with the potential to replace the classical volatile organic solvents, stimulating many applications in chemical industry. In case ILs are released to the environment, possible combined toxicity should be taken into account and it is, however, often neglected up to now. In this paper, therefore, the concentration-response curves (CRCs) of four groups of IL mixtures with various mixture ratios to Vibrio qinghaiensis sp.-Q67 were determined using the microplate toxicity analysis and were compared to the CRCs predicted by an additive reference model, the concentration addition (CA) or independent action (IA), to identify the toxicity interaction. It is showed that most of the IL mixture rays displayed the classical addition while the remaining rays exhibited antagonism or synergism. Moreover, it is found that the pEC₅₀ values of the mixture rays exhibiting antagonism or synergism are well correlated with the mixture ratio of a certain IL therein.
authors.affiliation: Tongji University, Shanghai, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Shu-Shen
authors.initials: SS
authors.lastname: Liu
authors.forename: Rong-Ni
authors.initials: RN
authors.lastname: Dou
authors.forename: Hai-Ling
authors.initials: HL
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004357:Drug Synergism; D052578:Ionic Liquids / Q000737:chemistry / Q000633:toxicity*; D014733:Vibrio; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000633:toxicity*
chemical_list: D052578:Ionic Liquids; D014874:Water Pollutants, Chemical