title: Increased soluble OX40L is associated with carotid intima-media thickness.
abstract: BACKGROUND
  Recent studies indicated that soluble OX40 ligand (OX40L) levels were increased in acute coronary syndrome. But the association between sOX40L and carotid intima-media thickness (IMT) has not been evaluated.
  
  
  METHODS
  We measured plasma soluble OX40L (sOX40L) and Interleukin-10 (IL-10) levels in 35 patients with stable angina pectoris, 30 patients with risk factors of coronary artery disease, and 20 age and sex-matched controls. Carotid (IMT) was measured by B-mode ultrasound.
  
  
  RESULTS
  Plasma sOX40L levels were positively correlated with Carotid IMT (r = 0.376, P = 0.001) and inversely correlated with IL-10 (P = -0.394, P = 0.000). Multivariate linear regression analysis revealed that sOX40L (p = 0.019) was an independent predictor for Carotid IMT progression after adjusting for the classical cardiovascular risk factors.
  
  
  CONCLUSIONS
  sOX40L is independently related to Carotid IMT, suggesting the possible relationship of OX40L to atherosclerosis. The positive relation of sOX40L to C-reactive protein (CRP) and the negative relation to IL-10 indicated the possible proinflammatory effects of OX40L on the pathogenesis of atherosclerois.
authors.affiliation: Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, China. pengdq@hotmail.com
authors.forename: Dao-Quan
authors.initials: DQ
authors.lastname: Peng
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Yuan
authors.forename: Shui-Ping
authors.initials: SP
authors.lastname: Zhao
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D000787:Angina Pectoris / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D053278:OX40 Ligand / Q000097:blood / Q000378:metabolism*; D018570:Risk Assessment; D012307:Risk Factors; D017539:Tunica Intima / Q000378:metabolism* / Q000473:pathology; D017540:Tunica Media / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D053278:OX40 Ligand; C089251:TNFSF4 protein, human; D016753:Interleukin-10