title: The meaning of pausing.
abstract: Pausing of RNA polymerase II (RNAPII) at the 5' end of genes is a widespread phenomenon in metazoans, but the role of this event in gene regulation is poorly understood. Gilchrist et al. (2010) now demonstrate that RNAPII pausing counteracts DNA-influenced nucleosome organization to allow precise gene activation.
authors.affiliation: Department of Molecular, Howard Hughes Medical Institute, The University of Colorado at Boulder, 347 UCB, Boulder, CO 80309-0347, USA. joaquin.espinosa@colorado.edu
authors.forename: Joaquín M
authors.initials: JM
authors.lastname: Espinosa