title: Anticoagulants: newer ones, mechanisms, and perioperative updates.
abstract: With a growing number of new anticoagulant/antiplatelet agents being developed, it is likely that an increasing number of patients taking these drugs will present for surgery and other procedures. A familiarity with mechanisms of action and drug interactions helps to maintain optimal patient safety in the perioperative period. Furthermore, it is crucial for anesthesiologists to remain current on recommendations regarding discontinuation or need to continue the newer anticoagulants/antiplatelet drugs in patients presenting for surgery and/or regional anesthesia. Further studies are needed for monitoring of many of these newer agents and to identify antidotes.
authors.affiliation: Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Jgayle477@cox.net
authors.forename: Julie A
authors.initials: JA
authors.lastname: Gayle
authors.forename: Alan D
authors.initials: AD
authors.lastname: Kaye
authors.forename: Adam M
authors.initials: AM
authors.lastname: Kaye
authors.forename: Rinoo
authors.initials: R
authors.lastname: Shah
mesh_terms: D000765:Anesthesia, Conduction; D000925:Anticoagulants / Q000494:pharmacology*; D000991:Antithrombins / Q000494:pharmacology; D065427:Factor Xa Inhibitors; D006801:Humans; D059035:Perioperative Period; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D058921:Purinergic P2Y Receptor Antagonists / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D065427:Factor Xa Inhibitors; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D058921:Purinergic P2Y Receptor Antagonists