title: Septic arthritis caused by Legionella dumoffii in a patient with systemic lupus erythematosus-like disease.
abstract: We describe a patient with systemic lupus erythematosus (SLE)-like disease on immunosuppressive treatment who developed septic arthritis of the knee involving Legionella dumoffii. Cultures initially remained negative. A broad-range 16S PCR using synovial fluid revealed L. dumoffii rRNA genes, a finding that was subsequently confirmed by positive Legionella culture results.
authors.affiliation: Department of Rheumatology, Sint Maartenskliniek Nijmegen, Hengstdal 3, P.O. Box 9011, 6500 GM, Nijmegen, Netherlands. m.flendrie@flen.nl
authors.forename: M
authors.initials: M
authors.lastname: Flendrie
authors.forename: M
authors.initials: M
authors.lastname: Jeurissen
authors.forename: M
authors.initials: M
authors.lastname: Franssen
authors.forename: D
authors.initials: D
authors.lastname: Kwa
authors.forename: C
authors.initials: C
authors.lastname: Klaassen
authors.forename: F
authors.initials: F
authors.lastname: Vos
mesh_terms: D001170:Arthritis, Infectious / Q000382:microbiology*; D004269:DNA, Bacterial / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D007875:Legionella / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D007876:Legionellosis / Q000175:diagnosis* / Q000382:microbiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D007166:Immunosuppressive Agents; D012336:RNA, Ribosomal, 16S