title: [Effects of gadolinium chloride on sodium taurocholate-induced pancreatitis in rats].
abstract: OBJECTIVE
  To evaluate the effects of the use of gadolinium chloride before and after induction of acute pancreatitis with sodium taurocholate 3% in rats.
  
  
  METHODS
  Wistar rats were divided into five groups: SF--control with saline intra-ductal and IV; GD control with saline intra-ductal and gadolinium chloride IV; TS--with AP control induced by sodium taurocholate 3% and saline IV; GDTS--pre-treatment with GD (24 hours before the induction of AP) and TSGD--treatment with GD (1 hour after the induction of AP). Analysis was made in serum amylase, transaminases and TNF-α; determination of the MPO activity in lung tissue, lung and pancreatic histology.
  
  
  RESULTS
  The number of dead animals before the end of the experiment was significantly higher in TSGD (P = 0.046). The scores of pancreatitis and lung damage were higher in the groups that used sodium taurocholate compared to groups with intra-ductal infusion of saline solution. There were no differences in other variables studied when comparing TS, GDTS and TSGD groups.
  
  
  CONCLUSIONS
  The benefits with the use of gadolinium chloride as a prophylactic and therapeutic drug were not demonstrated.
authors.affiliation: Laboratório de Hepatologia Experimental-Fisiologia, Hospital de Clínicas de Porto Alegre, RS, BR. dmossmann@gmail.com
authors.forename: Diego da Fonseca
authors.initials: Dda F
authors.lastname: Mossmann
authors.forename: Maria Isabel Albano
authors.initials: MI
authors.lastname: Edelweiss
authors.forename: Jane Maria
authors.initials: JM
authors.lastname: Kulczynski
authors.forename: Norma Anair Possa
authors.initials: NA
authors.lastname: Marroni
authors.forename: Nélson Alexandre
authors.initials: NA
authors.lastname: Kretzmann
authors.forename: Catiele
authors.initials: C
authors.lastname: Antunes
authors.forename: Oscar Augusto
authors.initials: OA
authors.lastname: Birkhan
authors.forename: Alessandro Bersch
authors.initials: AB
authors.lastname: Osvaldt
mesh_terms: D000818:Animals; D003287:Contrast Media; D005682:Gadolinium / Q000627:therapeutic use*; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D013656:Taurocholic Acid
chemical_list: D003287:Contrast Media; D013656:Taurocholic Acid; D005682:Gadolinium; C038958:gadolinium chloride