title: Comparison of induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone in term primigravidae.
abstract: OBJECTIVE
  To compare the efficacy and complications of intravaginal misoprostol application before starting oxytocin infusion with oxytocin infusion alone for labor induction in term primigravidae pregnancies with low-Bishop score.
  
  
  METHODS
  This randomized study included 101 primigravidae women with singleton pregnancies >38 weeks and a Bishop score of <6. Group 1 (50 patients) received a 50-μg dose of intravaginal misoprostol, with an oxytocin infusion started 3 h later. Group 2 (51 patients) received only an oxytocin infusion for labor induction. The time from induction to delivery, the route of delivery and complications were analyzed.
  
  
  RESULTS
  The mean time from induction to delivery was 10.4 ± 2.1 h in Group 1 and 13.7 ± 3.4 in Group 2 (p < 0.001). The rates of vaginal delivery, Apgar scores at 1st and 5th min, placental abruption, and postpartum hemorrhage were similar between the two groups.
  
  
  CONCLUSIONS
  Intravaginal application of 50-μg misoprostol before starting oxytocin infusion is a more effective method of labor induction than oxytocin infusion alone in term primigravidae pregnant women with low-Bishop scores.
authors.affiliation: Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Konya, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Balci
authors.forename: Alaa S
authors.initials: AS
authors.lastname: Mahmoud
authors.forename: Ali
authors.initials: A
authors.lastname: Acar
authors.forename: Mehmet C
authors.initials: MC
authors.lastname: Colakoglu
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D020073:Gravidity / Q000502:physiology; D006801:Humans; D007751:Labor, Induced / Q000009:adverse effects / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects; D006473:Postpartum Hemorrhage / Q000139:chemically induced / Q000453:epidemiology; D011247:Pregnancy; D047929:Term Birth / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
chemical_list: D004338:Drug Combinations; D010120:Oxytocics; D016595:Misoprostol; D010121:Oxytocin