title: Sleep stage transitions in chronic fatigue syndrome patients with or without fibromyalgia.
abstract: Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are medically unexplained conditions that share considerable overlapping symptoms, including sleep-related complaints. However, differences between the two conditions have been reported, and we hypothesized that dynamic aspects of sleep, recently attracting scientific interests, would be different in the two groups of patients. We thus study transition probabilities between sleep stages of CFS patients with or without FM. Subjects were 26 healthy controls, 14 CFS patients without FM (CFS alone) and 12 CFS patients with FM (CFS+FM) - all women. We studied transition probabilities between sleep stages (waking, REM sleep and Stage I, Stage II and slow-wave sleep (Stage III+IV)). We found that probabilities of transition from REM sleep to waking were significantly greater in CFS alone than in controls; we have reported previously this sleep disruption as the specific sleep problem for CFS alone [Kishi et al., 2008]. Probabilities of transitions from waking, REM sleep and Stage I to Stage II, and those from slow-wave sleep to Stage I, were significantly greater in CFS+FM than in controls; the former might indicate increased sleep pressure in CFS+FM and the latter may be the specific sleep problem of CFS+FM. These results suggest that CFS and FM are different illnesses associated with different problems of sleep regulation.
authors.affiliation: Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, 113-0033, Japan. kishi@p.u-tokyo.ac.jp
authors.forename: Akifumi
authors.initials: A
authors.lastname: Kishi
authors.forename: Benjamin H
authors.initials: BH
authors.lastname: Natelson
authors.forename: Fumiharu
authors.initials: F
authors.lastname: Togo
authors.forename: Zbigniew R
authors.initials: ZR
authors.lastname: Struzik
authors.forename: David M
authors.initials: DM
authors.lastname: Rapoport
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D012894:Sleep Stages / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology