title: Shaping the T-cell repertoire in the periphery.
abstract: Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self-reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens. The implications of peripheral T-cell selection for the immune response as animals age are discussed as is the critical role of dendritic cells in directing T-cell differentiation.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Stacey
authors.initials: S
authors.lastname: Allen
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Turner
authors.forename: Dorothée
authors.initials: D
authors.lastname: Bourges
authors.forename: Paul A
authors.initials: PA
authors.lastname: Gleeson
authors.forename: Ian R
authors.initials: IR
authors.lastname: van Driel
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D017637:Clonal Deletion / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism