title: Heat shock proteins are important mediators of skeletal muscle insulin sensitivity.
abstract: Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.
authors.affiliation: University of Kansas Medical Center, Department of Molecular and Integrative Physiology, Kansas City, KS 66160, USA. pgeiger@kumc.edu
authors.forename: Paige C
authors.initials: PC
authors.lastname: Geiger
authors.forename: Anisha A
authors.initials: AA
authors.lastname: Gupte
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000517:prevention & control; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D018482:Muscle, Skeletal / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: D006360:Heat-Shock Proteins; D007328:Insulin