title: Myc transcription factors: key regulators behind establishment and maintenance of pluripotency.
abstract: The interplay between transcription factors, epigenetic modifiers, chromatin remodelers and miRNAs form the foundation of a complex regulatory network required for establishment and maintenance of the pluripotent state. Recent work indicates that Myc transcription factors are essential elements of this regulatory system. However, despite numerous studies, aspects of how Myc controls self-renewal and pluripotency remain obscure. This article reviews evidence supporting the placement of Myc as a central regulator of the pluripotent state and discusses possible mechanisms of action.
authors.affiliation: Paul D Coverdell Center for Biomedical & Health Sciences, Department of Biochemistry & Molecular Biology, University of Georgia, 500 DW Brooks Drive, Athens, GA 30602, USA.
authors.forename: Keriayn
authors.initials: K
authors.lastname: Smith
authors.forename: Stephen
authors.initials: S
authors.lastname: Dalton
mesh_terms: D000818:Animals; D047108:Embryonic Development; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D033581:Stem Cell Transplantation; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors