title: Therapy and outcome of primitive neuroectodermal tumor of the jaw.
abstract: Data pertaining to outcomes in jaw primitive neuroectodermal tumor (PNET) are lacking. Eleven cases of jaw PNET (five maxillary and six mandibular) were treated at our cancer center with the same chemotherapeutic agents from June 2003 to January 2009. Four patients underwent surgery after neoadjuvant chemotherapy and all received local radiotherapy. At median follow-up of 56 months (range: 19-77 months), 7/11 patients are in sustained remission. There was no difference in outcome with respect to site of tumor, and whether surgery was performed or not. These results support the use of chemoradiation as initial modality of treatment rather than going for extensive and mutilating surgery.
authors.affiliation: Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India. sambakh@hotmail.com
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.forename: Subha
authors.initials: S
authors.lastname: Pathania
authors.forename: B K
authors.initials: BK
authors.lastname: Mohanti
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
authors.forename: Alok
authors.initials: A
authors.lastname: Thakar
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D020360:Neoadjuvant Therapy; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology / Q000628:therapy*; D011829:Radiation Dosage; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult