title: [Association of idiopathic thrombocytopenic purpura and type 1 diabetes mellitus--a case report].
abstract: The relation between type 1 diabetes mellitus and autoimmune thyroid diseases is well known. In the pathogenesis of both diseases, chronic autoimmunization plays an essential role. Specific autoantibodies are also responsible for the onset of idiopathic thrombocytopenic purpura. In the paper we present a case of an 11-year-old girl with insulin dependent diabetes in whom the idiopathic thrombocytopenic purpura without bleeding diathesis has been newly diagnosed. The patient had positive titres of thyroid autoantibodies, whilst she did not suffer from thyroid dysfunction. Due to inefficiency of intravenous gammaglobulins the patient was treated with a steroid therapy, which elevated the platelet counts to safe levels. However, the episodes of hyperglycemia have appeared as a side effect. The insulin therapy was modified and the girl was released in a good condition. In this case report, consideration should be given to the wide range of autoimmune diseases that can accompany type one diabetes mellitus--not only can we observe immune diabetic markers, but also thyroid autoantibodies and anti-platelet antibodies. Particular therapeutic dilemmas resulting in a difficult decision on steroid therapy while treating a diabetic patient with idiopathic thrombocytopenic purpura are also presented.
authors.affiliation: Klinika Pediatrii, Endokrynologii i Diabetologii Dzieciecej Slaskiego Uniwersytetu Medycznego w Katowicach. katarzyna.prusek@hotmail.com
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Prusek
authors.forename: Grażyna
authors.initials: G
authors.lastname: Deja
authors.forename: Przemysława
authors.initials: P
authors.lastname: Jarosz-Chobot
mesh_terms: D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis* / Q000276:immunology*