title: Dapoxetine for premature ejaculation.
abstract: Premature ejaculation (PE) is the most common form of male sexual dysfunction, with an estimated worldwide prevalence of 20–30%.1 Although PE is not life threatening, it has significant impact on quality of life. The fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)defines PE as “persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it” that “causes marked distress or interpersonal difficulty” and “is not due exclusively to the direct effects of a substance.”2 The International Society for Sexual Medicine, which recently modified the definition to include the threshold ejaculatory latency time, defines PEas “male sexual dysfunction characterized by ejaculation which always or nearly always occurs prior to or within 1 min of vaginal penetration; the inability to delay ejaculation on all or nearly all vaginal penetrations; and negative personal consequences such as distress, bother, frustration, and/or the avoidance of sexual intimacy.”3 The lack of ejaculatory control is consistent among all clinical definitions of PE and is a highly sensitive predictor of the condition.
authors.affiliation: Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Feige
authors.forename: M R
authors.initials: MR
authors.lastname: Pinsky
authors.forename: W J G
authors.initials: WJ
authors.lastname: Hellstrom
mesh_terms: D000818:Animals; D001596:Benzylamines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004542:Ejaculation / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D020033:Protein Isoforms / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D001596:Benzylamines; D009281:Naphthalenes; D020033:Protein Isoforms; D011985:Receptors, Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; C080598:dapoxetine