title: Molecular and cellular radiobiological effects of Auger emitting radionuclides.
abstract: Although the general radiobiologic principles underlying external beam therapy and radionuclide therapy are similar, significant differences in the biophysical and radiobiologic effects from the two types of radiation continue to accumulate. Here, I will address the unique features that distinguish the molecular and cellular radiobiological effects of Auger electron-emitting radionuclides consequent to (1) the physical characteristics of the decaying atom and its subcellular localisation, (2) DNA topology and (3) the bystander effect. Based on these experimental findings, I postulate that the ability of track structural simulations as primary tools in modelling DNA damage and cellular survival at the molecular level would be greatly enhanced when these contributions are factored in.
authors.affiliation: Department of Radiology, Harvard Medical School, 200 Longwood Avenue, Armenise Building Room D2-137, Boston, MA 02115, USA. amin_kassis@hms.harvard.edu
authors.forename: Amin I
authors.initials: AI
authors.lastname: Kassis
mesh_terms: D000818:Animals; D024201:Bystander Effect / Q000528:radiation effects*; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011829:Radiation Dosage; D011868:Radioisotopes / Q000494:pharmacology*
chemical_list: D011868:Radioisotopes; D004247:DNA