title: Protective interleukin-28B genotype affects hepatitis C virus clearance, but does not contribute to HIV-1 control in a cohort of African-American elite controllers/suppressors.
abstract: We tested the hypothesis that a single nucleotide polymorphism (SNP) located near the interleukin-28B gene is associated with the control of hepatitis C virus and HIV-1 replication in elite controllers/suppressors. We show here that the protective genotype is not overrepresented in elite controllers/suppressors compared with HIV-1-seronegative patients and HIV-1-infected patients with viral loads more than 10 000 copies/ml. Thus, it appears that this SNP is not associated with the elite control of HIV-1 infection.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Salgado
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Kirk
authors.forename: Andrea
authors.initials: A
authors.lastname: Cox
authors.forename: Alleluiah
authors.initials: A
authors.lastname: Rutebemberwa
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Higgins
authors.forename: Jacquie
authors.initials: J
authors.lastname: Astemborski
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.forename: Chloe L
authors.initials: CL
authors.lastname: Thio
authors.forename: Mark S
authors.initials: MS
authors.lastname: Sulkowski
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
mesh_terms: D001741:Black or African American / Q000235:genetics*; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D019562:Viral Load; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda