title: Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?
abstract: In our previous study, we observed that the presence of autoimmune thyroid disease worsens fibromyalgia (FM) symptoms. The aims of this study are to evaluate whether there is a predisposition for the development of FM in patients with Hashimoto's thyroiditis (HT) with or without subclinical hypothyroidism (SCH) and in patients with SCH alone and what is the weight of antithyroid antibody positivity and SCH on FM comorbidity. Fifty-two patients, 39 affected by HT with or without SCH and 13 by SCH, were matched with 37 patients affected by FM and 25 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, antithyroperoxidase antibody (TPOAb), antithyroglobulin antibody (TgAb) and non-organ-specific autoantibodies. Clinical assessment of patients and controls included the "Fibromyalgia Impact Questionnaire" (FIQ), while pain severity was evaluated using a visual analogue scale (VAS). Patients and controls were also characterized by the presence of diffuse pain, fatigue, paresthesiae, muscle spasms, non-restful sleep, tension headache and presence of mood disorders. FM comorbidity resulted in twelve HT subjects (31%) and none in SCH patient. In particular, FM comorbidity in HT patients without SCH was 33.3% and in HT patients with SCH was 28.5%. Based on our data, we speculate that maybe there is more than a hypothesis regarding the cause-effect relation between thyroid autoimmunity and the presence of FM, thus suggesting a hypothetical role of thyroid autoimmunity in FM pathogenesis.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy. l.bazzichi@int.med.unipi.it
authors.forename: L
authors.initials: L
authors.lastname: Bazzichi
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Zirafa
authors.forename: F
authors.initials: F
authors.lastname: Monzani
authors.forename: S
authors.initials: S
authors.lastname: Tognini
authors.forename: A
authors.initials: A
authors.lastname: Dardano
authors.forename: F
authors.initials: F
authors.lastname: Santini
authors.forename: M
authors.initials: M
authors.lastname: Tonacchera
authors.forename: M
authors.initials: M
authors.lastname: De Servi
authors.forename: C
authors.initials: C
authors.lastname: Giacomelli
authors.forename: F
authors.initials: F
authors.lastname: De Feo
authors.forename: M
authors.initials: M
authors.lastname: Doveri
authors.forename: G
authors.initials: G
authors.lastname: Massimetti
authors.forename: S
authors.initials: S
authors.lastname: Bombardieri
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology*; D015331:Cohort Studies; D015897:Comorbidity / Q000639:trends; D005260:Female; D005356:Fibromyalgia / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D050031:Hashimoto Disease / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013961:Thyroid Gland / Q000276:immunology*