title: HLA polymorphisms in Italian children with autism spectrum disorders: results of a family based linkage study.
abstract: To verify correlations between HLA and autism spectrum disorders (ASD) we studied 61 Italian families with an ASD child; results showed such correlation in 65% of cases. Case-control and TDT analysis of intrafamilial transmission of SNPs, Msats, and HLA markers surrounding the α and β blocks, indicated significant positive associations for MOGc*131 and D6S2239*105 alleles in ASD, and a negative association of MIB *332 allele in healthy siblings. Polymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD. MOGc and MIB loci are linked with ASD in Italian patients.
authors.affiliation: Laboratory of Molecular Medicine and Biotechnologies, Don C Gnocchi Foundation IRCCS, S Maria Nascente, Milan, Italy. fguerini@dongnocchi.it
authors.forename: Franca R
authors.initials: FR
authors.lastname: Guerini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bolognesi
authors.forename: Matteo
authors.initials: M
authors.lastname: Chiappedi
authors.forename: Annalisa
authors.initials: A
authors.lastname: De Silvestri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ghezzo
authors.forename: Michela
authors.initials: M
authors.lastname: Zanette
authors.forename: Beatrice
authors.initials: B
authors.lastname: Rusconi
authors.forename: Salvatorica
authors.initials: S
authors.lastname: Manca
authors.forename: Stefano
authors.initials: S
authors.lastname: Sotgiu
authors.forename: Cristina
authors.initials: C
authors.lastname: Agliardi
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007558:Italy; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: D006680:HLA Antigens