title: Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls.
abstract: The abundance of a selection of transcript species involved in inflammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2-4 after hospitalization) or convalescence phase (days 7-10) and 28 healthy aged controls. Twenty-nine differentially abundant transcripts were identified in acute phase versus healthy ageing. Twelve of these transcripts remained differentially abundant in convalescence phase, and 22 were similarly differentially abundant in acute phase of geriatric infectious diseases. Seven of these 22 transcripts were previously identified as differentially abundant in PBMC of healthy aged versus healthy young controls, with further alteration for CD28, CD69, LCK, CTSD, HMOX1, and TNFRSF1A in acute phase after geriatric hip fracture and infectious diseases. The next question is whether these alterations are common to other geriatric diseases and/or preexist before the clinical onset of the diseases.
authors.affiliation: Unit of Research on Cellular Biology, NARILIS-Namur Research Institute for Life Sciences, University of Namur (FUNDP), Rue de Bruxelles 61, B-5000 Namur, Belgium.
authors.forename: Thi Kim Duy
authors.initials: TK
authors.lastname: Vo
authors.forename: Patrice
authors.initials: P
authors.lastname: Godard
authors.forename: Marie
authors.initials: M
authors.lastname: de Saint-Hubert
authors.forename: Gabriel
authors.initials: G
authors.lastname: Morrhaye
authors.forename: Florence
authors.initials: F
authors.lastname: Debacq-Chainiaux
authors.forename: Christian
authors.initials: C
authors.lastname: Swine
authors.forename: Vincent
authors.initials: V
authors.lastname: Geenen
authors.forename: Henri J
authors.initials: HJ
authors.lastname: Martens
authors.forename: Olivier
authors.initials: O
authors.lastname: Toussaint
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000235:genetics; D015703:Antigens, CD / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D001483:Base Sequence; D018106:CD28 Antigens / Q000235:genetics; D016022:Case-Control Studies; D002402:Cathepsin D / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D051547:Heme Oxygenase-1 / Q000235:genetics; D006620:Hip Fractures / Q000097:blood* / Q000235:genetics*; D006760:Hospitalization; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000235:genetics; D008297:Male; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D002402:Cathepsin D; D017931:DNA Primers; D051547:Heme Oxygenase-1; D037181:Lectins, C-Type; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D047888:Receptors, Tumor Necrosis Factor, Type I; D000099192:CD69 Antigens; C506235:TNFRSF1A protein, human; C496541:HMOX1 protein, human; C533922:CTSD protein, human