title: Building addressable libraries: the use of "safety-catch" linkers on microelectrode arrays.
abstract: A "safety-catch" linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.
authors.affiliation: Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Bi
authors.forename: Karl
authors.initials: K
authors.lastname: Maurer
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Moeller
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007783:Lactones / Q000737:chemistry; D046228:Microarray Analysis / Q000295:instrumentation*; D008839:Microelectrodes; D054852:Small Molecule Libraries / Q000737:chemistry*
chemical_list: D007783:Lactones; D054852:Small Molecule Libraries