title: Long-term effect of latanoprost on central corneal thickness in normal tension glaucoma.
abstract: OBJECTIVE
  To evaluate the long-term effect of latanoprost on central corneal thickness (CCT) in patients with normal tension glaucoma (NTG).
  
  
  METHODS
  This was a retrospective study and included 166 eyes of 166 patients [128 with NTG and 38 with glaucoma suspect, suspicious discs with normal visual fields, and an intraocular pressure (IOP) ≤21  mmHg as the control group]. Patients with newly diagnosed NTG and who had not had previous topical glaucomatous treatment were followed ≥24 months and received latanoprost 0.005% monotherapy once a day. CCT measurements were performed with an ultrasound pachymeter. CCT measurements before treatment and 24 months after treatment were analyzed.
  
  
  RESULTS
  There were no significant differences between the latanoprost group and the control group with respect to sex, age, baseline IOP, and CCT. A statistically significant reduction in the mean CCT was observed in the latanoprost group [535.5 ± 37.9 vs. 530.1 ± 36.4  μm (n = 128), P < 0.01], but not in the control group [543.1 ± 40.2 vs. 542.6 ± 37.0  μm (n = 38), P = 0.786].
  
  
  CONCLUSIONS
  Long-term use of latanoprost may decrease the CCT in patients with NTG. Therefore, clinicians must be aware of longitudinal CCT variations that may arise throughout the follow-up period for proper IOP targeting and management.
authors.affiliation: Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Kim
authors.forename: Byung Joo
authors.initials: BJ
authors.lastname: Cho
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003315:Cornea / Q000000981:diagnostic imaging* / Q000187:drug effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D000077338:Latanoprost; D008137:Longitudinal Studies; D057066:Low Tension Glaucoma / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D012189:Retrospective Studies; D014463:Ultrasonography; D014794:Visual Fields
chemical_list: D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost