title: European registry of infants born to mothers with antiphospholipid syndrome: preliminary results.
abstract: The registry is an European, multicentre, prospective and longitudinal study which follows a cohort of children born to mothers with antiphospholipid syndrome (APS). In this article we report preliminary results obtained from 138 mothers and 141 babies (three twin pregnancies). At birth, 16.3% of neonates were less than 37 weeks of gestation and 17% were low birth weight; in addition, 11.3% of neonates were small for gestational age. No cases of neonatal thrombosis were observed. During follow-up period five children showed behavioral abnormalities. A long term clinical follow-up will be necessary to evaluate the neuropsychological development of these children.
authors.affiliation: Neonatology and Neonatal Intensive Care, Children's Hospital of Brescia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Motta
authors.forename: E
authors.initials: E
authors.lastname: Lachassinne
authors.forename: M C
authors.initials: MC
authors.lastname: Boffa
authors.forename: A
authors.initials: A
authors.lastname: Tincani
authors.forename: T
authors.initials: T
authors.lastname: Avcin
authors.forename: S
authors.initials: S
authors.lastname: De Carolis
authors.forename: M H
authors.initials: MH
authors.lastname: Aurousseau
authors.forename: P
authors.initials: P
authors.lastname: Le Toumelin
authors.forename: A
authors.initials: A
authors.lastname: Lojacono
authors.forename: M P
authors.initials: MP
authors.lastname: De Carolis
authors.forename: G
authors.initials: G
authors.lastname: Chirico
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000453:epidemiology*; D001321:Autistic Disorder / Q000453:epidemiology / Q000209:etiology; D002675:Child, Preschool; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D019102:Infant, Very Low Birth Weight; D007859:Learning Disabilities / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D047928:Premature Birth / Q000453:epidemiology; D011446:Prospective Studies; D011596:Psychomotor Disorders / Q000453:epidemiology / Q000209:etiology; D012042:Registries; D013927:Thrombosis / Q000151:congenital / Q000453:epidemiology; D014427:Twins
chemical_list: D017152:Antibodies, Antiphospholipid