title: A positive association between homeostasis model assessment of insulin resistance score and the Trp64Arg polymorphism of the β3-Adrenergic receptor gene in schizophrenia patients in Taiwan.
abstract: OBJECTIVE
  To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan.
  
  
  METHODS
  A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance.
  
  
  RESULTS
  After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P = .033).
  
  
  CONCLUSIONS
  The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.
authors.affiliation: Department of Health, Jianan Mental Hospital, Taiwan.
authors.forename: Hsien-Jane
authors.initials: HJ
authors.lastname: Chiu
authors.forename: Ming-Yih
authors.initials: MY
authors.lastname: Lee
authors.forename: Tzuo-Yun
authors.initials: TY
authors.lastname: Lan
authors.forename: El-Wui
authors.initials: el-W
authors.lastname: Loh
authors.forename: Jau-Tay
authors.initials: JT
authors.lastname: Wang
authors.forename: Tsuo-Hung
authors.initials: TH
authors.lastname: Lan