title: Vascular lumen formation: negativity will tear us apart.
abstract: Functional blood vessels are essential for vertebrate development, but how endothelial cells initiate lumen formation during vasculogenesis is not known. A new study now reveals that electrostatic repulsion is key.
authors.affiliation: Northwestern University, Department of Molecular Biosciences, Evanston, IL 60208, USA.
authors.forename: Renée M
authors.initials: RM
authors.lastname: Robbins
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Beitel
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D001808:Blood Vessels / Q000166:cytology / Q000187:drug effects / Q000196:embryology*; D002448:Cell Adhesion; D002460:Cell Line; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D019158:N-Acetylneuraminic Acid / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000502:physiology; D012795:Sialoglycoproteins / Q000235:genetics / Q000378:metabolism; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D018952:Antigens, CD34; D012795:Sialoglycoproteins; C001643:podocalyxin; D019158:N-Acetylneuraminic Acid