title: Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer.
abstract: Early detection of cancer is key to reducing morbidity and mortality. Morphological and chemical biomarkers presage the transition from normal to cancerous tissue. We have developed a noninvasive imaging system incorporating optical coherence tomography and fluorescence lifetime imaging to acquire both sets of biomarkers. Here we report early favorable results from an animal study designed to measure the capacity of this approach for early diagnosis of oral cancer.
authors.affiliation: Department of Biomedical Engineering at Texas A&M University, College Station, TX, USA.
authors.forename: Sebina
authors.initials: S
authors.lastname: Shrestha
authors.forename: Jesung
authors.initials: J
authors.lastname: Park
authors.forename: Paritosh
authors.initials: P
authors.lastname: Pande
authors.forename: Brian E
authors.initials: BE
authors.lastname: Applegate
authors.forename: Javier A
authors.initials: JA
authors.lastname: Jo
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D006224:Cricetinae; D046169:Dermoscopy / Q000379:methods; D003952:Diagnostic Imaging / Q000379:methods; D004195:Disease Models, Animal; D006801:Humans; D008647:Mesocricetus; D015233:Models, Statistical; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000473:pathology*; D055095:Optics and Photonics / Q000379:methods; D012984:Software; D041623:Tomography, Optical Coherence / Q000379:methods