title: Sterile inflammation: sensing and reacting to damage.
abstract: Over the past several decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns, which are the conserved microbial motifs sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns. The sterile inflammation that ensues either resolves the initial insult or leads to disease. Here, we review the triggers and receptor pathways that result in sterile inflammation and its impact on human health.
authors.affiliation: Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Michigan 48109, USA. gchenry@umich.edu
authors.forename: Grace Y
authors.initials: GY
authors.lastname: Chen
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nuñez
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology; D051379:Mice; D017382:Reactive Oxygen Species / Q000276:immunology / Q000633:toxicity; D051192:Receptors, Pattern Recognition / Q000276:immunology; D015427:Reperfusion Injury / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species; D051192:Receptors, Pattern Recognition