title: Metformin and troglitazone in the treatment of female infertility associated with polycystic ovarian syndrome.
abstract: Polycystic ovarian syndrome is the most common cause of anovulatory infertility and causes menstrual disruption in 5-10% females, and is characterized by insulin resistance, hyperinsulinemia, hyperandrogenism and anovulation. Such factors are responsible for the increased miscarriage and infertility in women with PCOS. Administration of various insulin sensitizing drugs, such as metformin and troglitazone have been shown to decrease serum androgen concentrations and to increase ovulation rates, increase conception and decrease miscarriage in affected women.
authors.affiliation: Department of clinical Pharmacology and Therapeutics, BPKIHS, Dharan, Nepal.
authors.forename: H
authors.initials: H
authors.lastname: Sangraula
authors.forename: K R
authors.initials: KR
authors.lastname: Paudel
authors.forename: M
authors.initials: M
authors.lastname: Sharma
mesh_terms: D000858:Anovulation / Q000188:drug therapy* / Q000209:etiology; D002839:Chromans / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000628:therapy; D045162:Thiazolidinediones / Q000627:therapeutic use*; D000077288:Troglitazone
chemical_list: D002839:Chromans; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D008687:Metformin; D000077288:Troglitazone