title: Three new terpenoid indole alkaloids from Catharanthus roseus.
abstract: Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4-10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR). Cytotoxic activities of these isolates (1-10) were evaluated, but only compound 8 was active against HL-60, SMMC-7721, and A549 cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D030008:Catharanthus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002681:China; D018922:HL-60 Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D046948:Secologanin Tryptamine Alkaloids