title: CXCL10- a path to β-cell death.
abstract: The ability of the β-cells to control blood glucose levels depends on their function and mass. In both, type 1 and type 2 diabetes mellitus the main processes leading to β-cell failure are apoptosis and loss of function. Many studies demonstrate how cytokines and chemokines have an active role in triggering the immune-response against the β-cell population. In a recent study we have identified that the chemokine CXCL10 may play an active role in triggering β-cell destruction.  We have identified the Toll like receptor 4 as the receptor for CXCL10 and as new pathway for the induction of β-cell apoptosis. Our findings may open new therapeutic approaches to fight onset and progression of the disease.
authors.affiliation: Centre for Biomolecular Interactions Bremen, University of Bremen, Germany.
authors.forename: Federico
authors.initials: F
authors.lastname: Paroni
authors.forename: Erna
authors.initials: E
authors.lastname: Domsgen
authors.forename: Kathrin
authors.initials: K
authors.lastname: Maedler
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D016923:Cell Death / Q000235:genetics / Q000502:physiology; D054357:Chemokine CXCL10 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism
chemical_list: D054357:Chemokine CXCL10; D051197:Toll-Like Receptor 4