title: p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment.
abstract: p53 as a tumor suppressor protein has been implicated in multiple aspects of biological processes, including apoptosis, cell cycle arrest, senescence, metabolism, differentiation and angiogenesis. Recently, several studies have shown that p53 can induce autophagy in both transcription-dependent and -independent manners. Nonetheless, p53 may also inhibit autophagy. In addition, p53 participates in homeostatic regulation of energy metabolism, oxidative stress and amino acid metabolism. Although the relationship between autophagy and p53 is quite complicated, and has not been well elucidated, p53 may underlie key aspects of metabolism and cancer biology. Thus, understanding the novel functions of p53 may allow us to develop new anticancer therapeutic approaches.
authors.affiliation: Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
authors.forename: Xinbing
authors.initials: X
authors.lastname: Sui
authors.forename: Lijun
authors.initials: L
authors.lastname: Jin
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Huang
authors.forename: Shumin
authors.initials: S
authors.lastname: Geng
authors.forename: Chao
authors.initials: C
authors.lastname: He
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Hu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D001343:Autophagy; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53; D006706:Homeostasis; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008495:Medical Oncology / Q000379:methods; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000378:metabolism*; D018384:Oxidative Stress; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D019869:Phosphatidylinositol 3-Kinases