title: Immunohistochemical expression of oestrogen and progesterone receptors during experimental acute and chronic murine Schistosomiasis mansoni.
abstract: BACKGROUND
  The responsibility of Schistosoma mansoni in female infertility is still controversial. This study was conducted to evaluate the effect of acute and chronic schistosomiasis mansoni infection on the endometrium using immunohistochemical analysis of uterine hormone receptor expression.
  
  
  METHODS
  Twenty-four nonpregnant swiss albino mice were divided into three groups: control, noninfected; acute; and chronic Schistosoma mansoni infection. Histological sections of uterine specimens were examined by light microscope with an image analyzing system to detect structural histological, estrogen receptor (ER) and progesterone receptor (PR) expression in the endometrium.
  
  
  RESULTS
  No secretory phase was detected in the endometrium in acute and chronic Schistosoma infection. Hormone receptor expression (ER and PR) showed statistically significant differences among the groups (p< 0.05), with significant low ER hormone expression in chronic infection, compared to control proliferative, control secretory and acute infection cases, and statistically significant high PR expression in both acute and chronic infection cases compared to the control secretory cases (p< 0.05).
  
  
  CONCLUSIONS
  Schistosomiasis mansoni seems to have an important impact on the hormone expression of affected women. Further studies to explore the mechanism of such changes are recommended.
authors.affiliation: Obstetrics and Gynecology Department, Faculty of Medicine, Taibah University, Saudi Arabia.
authors.forename: Fawzia Ahmed
authors.initials: FA
authors.lastname: Habib
authors.forename: Mayssa Mohamed
authors.initials: MM
authors.lastname: Zaki
authors.forename: Amany Ahmed Abd
authors.initials: AA
authors.lastname: El-Aal
authors.forename: Maha Dia Eldean
authors.initials: MD
authors.lastname: Safwat
authors.forename: Magda Ahmed El
authors.initials: MA
authors.lastname: Domiaty
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D007150:Immunohistochemistry; D051379:Mice; D011960:Receptors, Estrogen / Q000032:analysis / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000032:analysis / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000378:metabolism*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone