title: Antitumor and immunomodulatory activity of arabinoxylans: a major constituent of wheat bran.
abstract: We aimed to investigate the antitumor activity of wheat bran arabinoxylans, including the role of its immunostimulatory effect. In S180 tumor-bearing mice arabinoxylan administration significantly inhibited the growth of mouse transplantable tumors and remarkably promoted thymus and spleen indexes, splenocyte proliferation, natural killer cell and macrophage phagocytosis activity, interleukin 2 production, and delayed-type hypersensitivity reaction. In addition, it increased peripheral leukocyte count, and bone-marrow cellularity in tumor-bearing mice. As the antitumor activity of arabinoxylans may be mediated via the improvement in the immune response, they can be considered an antitumor agent with immunomodulatory activity.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Liu
authors.forename: Tianxiu
authors.initials: T
authors.lastname: Qian
authors.forename: Guibo
authors.initials: G
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Fengjin
authors.initials: F
authors.lastname: Chang
authors.forename: Sumei
authors.initials: S
authors.lastname: Zhou
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D045744:Cell Line, Tumor; D002645:Chickens; D004043:Dietary Fiber / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012509:Sarcoma / Q000473:pathology; D012756:Sheep; D014990:Xylans / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D004043:Dietary Fiber; D007155:Immunologic Factors; D014990:Xylans; C085118:arabinoxylan