title: Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides.
abstract: There has been great interest in the development of extremely potent antibacterial lantibiotic peptides for medicinal use and in food preservation. Of central importance to this endeavor is a strong understanding of which parts of the peptides are required for activity and which parts are expendable. Nisin, lacticin 481, nukacin ISK-1, mersacidin, lacticin 3147 and haloduracin represent many different types of lantibiotic peptides. In recent years, considerable advances toward understanding the structure-activity relationship of each of these lantibiotic systems have been achieved. This review will focus on the individual systems and the valuable information obtained from the many mutants produced.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Avena C
authors.initials: AC
authors.lastname: Ross
authors.forename: John C
authors.initials: JC
authors.lastname: Vederas
mesh_terms: D000818:Animals; D001430:Bacteriocins / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology*; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000235:genetics* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D001430:Bacteriocins; D010455:Peptides