title: Tunable bifunctional silyl ether cross-linkers for the design of acid-sensitive biomaterials.
abstract: Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of biomaterials provide precise control over the rate of degradation and the release rate of entrapped cargo and yield a material that is intrinsically nontoxic. In this work, we designed nontoxic acid-sensitive biomaterials based on silyl ether chemistry. A host of silyl ether cross-linkers were synthesized and molded into relevant medical devices, including Trojan horse particles, sutures, and stents. The resulting devices were engineered to degrade under acidic conditions known to exist in tumor tissue, inflammatory tissue, and diseased cells. The implementation of silyl ether chemistry gave precise control over the rate of degradation and afforded devices that could degrade over the course of hours, days, weeks, or months, depending upon the steric bulk around the silicon atom. These novel materials could be useful for numerous biomedical applications, including drug delivery, tissue repair, and general surgery.
authors.affiliation: Departments of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Parrott
authors.forename: J Chris
authors.initials: JC
authors.lastname: Luft
authors.forename: James D
authors.initials: JD
authors.lastname: Byrne
authors.forename: John H
authors.initials: JH
authors.lastname: Fain
authors.forename: Mary E
authors.initials: ME
authors.lastname: Napier
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Desimone
mesh_terms: D000143:Acids / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D003432:Cross-Linking Reagents; D016503:Drug Delivery Systems; D015195:Drug Design; D004987:Ethers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: D000143:Acids; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D004987:Ethers; D014297:Trimethylsilyl Compounds