title: Toxicity of phosphor esters: Willy Lange (1900-1976) and Gerda von Krueger (1907-after 1970).
abstract: In 1851 Williamson serendipitously discovered a new and efficient way to produce ethers using ethyl iodide and potassium salts. Based on this new synthetic approach, the Frenchman Philippe de Clermont and the Muscovite Wladimir Moschnin, both élèves of Adolphe Wurtz in his Paris School of Chemistry, achieved the synthesis of the first ester of pyrophosphoric acid (TEPP). de Clermont "tasted" the new compound and although TEPP is a potent cholinesterase inhibitor he failed to recognize its toxicity. Almost a century later, in 1932, Willy Lange (1900-1976) and his graduate student Gerda v. Krueger (1907-after 1970) described the toxicity of organophosphonates. While the classic paper of the two "Uber Ester der Monofluorphosphorsäure." is cited by almost everybody working in the field, little is known about Lange and almost nothing about v. Krueger. This brief communication attempts to shed some light on the life of both.
authors.affiliation: Florida International University, College of Medicine (COM), University Park, Miami, 33199 FL, USA. georg.petroianu@fiu.edu
authors.forename: G A
authors.initials: GA
authors.lastname: Petroianu
mesh_terms: D002800:Cholinesterase Inhibitors / Q000266:history* / Q000633:toxicity*; D004952:Esters / Q000633:toxicity; D005858:Germany; D049673:History, 20th Century; D010755:Organophosphates / Q000266:history* / Q000633:toxicity*
chemical_list: D002800:Cholinesterase Inhibitors; D004952:Esters; D010755:Organophosphates