title: [Argyrophilic nucleolar organizer region associated proteins in adenomas with varying colonic dysplasia and adenocarcinoma].
abstract: Argyrophilic nucleolar organizer region associated (Ag-NOR) proteins were studied in rectosigmoid epithelial tumors for diagnostic purposes. Silver nitrate staining was carried out in accordance with the standardized protocol. The quantity, area, area index of Ag-NOR proteins were automatically determined by computer image analysis. There were statistically significant differences in the quantity, area, area index of Ag-NOR proteins between the groups: the mucosa (lower 2/3 crypts), mild, moderate, and severe dysplasia of adenoma. Only the estimation of the area index of Ag-NOR proteins indicated statistically significant differences between severe dysplasia and highly differentiated adenocarcinoma. Colonic adenomas showed a correlation of the activity of Ag-NOR proteins with epithelial dysplasia, but no correlation with the size and histological type of their structure.
authors.forename: A F
authors.initials: AF
authors.lastname: Lazarev
authors.forename: D S
authors.initials: DS
authors.lastname: Kobiakov
authors.forename: V V
authors.initials: VV
authors.lastname: Klimachev
authors.forename: A M
authors.initials: AM
authors.lastname: Avdalian
authors.forename: I P
authors.initials: IP
authors.lastname: Bobrov
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012835:Silver Nitrate / Q000737:chemistry; D013194:Staining and Labeling
chemical_list: D034961:Antigens, Nuclear; C051963:nucleolar organizer region associated proteins; D012835:Silver Nitrate