title: Lung transplantation in cystic fibrosis patients in the Czech Republic: initial single-center experience.
abstract: BACKGROUND
  Lung transplantation is a well established treatment for advanced lung diseases.
  
  
  METHODS
  We compared the clinical results of patients with cystic fibrosis (CF) entered into the waiting list with those of patients after lung transplantation.
  
  
  RESULTS
  Among 36 patients with CF on the waiting list, 23 underwent lung transplantation, 8 died, 3 are still on the waiting list, and 2 were excluded from the waiting list. The median waiting list time of 0.48 years (range, 0.03-2.37) was insignificantly longer for patients who died compared with transplanted patients (0.97 vs 0.44 years). Mortality of waiting-list patients was 25.8%. The median survival of transplant patients of 7.48 years (range 0.00-10.85 years) was significantly lower among patients who were colonized (BCC) versus those who were not Burkholderia cepacia complex (0.19 vs 7.48 years; P = .041). The 1-, 3-, and 5-year patient survivals after lung transplantation were 72.9, 54.4, and 54.4, respectively.
  
  
  CONCLUSIONS
  The results of patients with cystic fibrosis on the waiting list versus after lung transplantation in our center were similar to those reported in the literature. We confirmed a less favorable prognosis of BCC-colonized patients.
authors.affiliation: Department of Pulmonology, 2nd Medical Schoul of Charles University, Prague, Czech Republic.
authors.forename: L V
authors.initials: LV
authors.lastname: Bartáková
authors.forename: L
authors.initials: L
authors.lastname: Fila
authors.forename: S
authors.initials: S
authors.lastname: Adámek
authors.forename: J
authors.initials: J
authors.lastname: Pozniak
authors.forename: M
authors.initials: M
authors.lastname: Malý
authors.forename: J
authors.initials: J
authors.lastname: Burkert
authors.forename: J
authors.initials: J
authors.lastname: Šimonek
authors.forename: R
authors.initials: R
authors.lastname: Lischke
mesh_terms: D000293:Adolescent; D000328:Adult; D019121:Burkholderia Infections / Q000382:microbiology; D042602:Burkholderia cepacia complex / Q000302:isolation & purification; D002648:Child; D003550:Cystic Fibrosis / Q000382:microbiology / Q000401:mortality / Q000601:surgery*; D018153:Czech Republic; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014850:Waiting Lists / Q000401:mortality; D055815:Young Adult