title: Isolated corneal papilloma-like lesion associated with human papilloma virus type 6.
abstract: OBJECTIVE
  To report a case of a corneal papilloma-like lesion associated with human papilloma virus type 6.
  
  
  METHODS
  A 48-year-old woman presented with a 2-year history of ocular discomfort and gradual visual deterioration in her right eye. Ophthalmic examination revealed an elevated, semitranslucent, well-defined vascularized mass approximately 4 × 2.5 mm in size localized to the right cornea. The surface of the mass appeared smooth and many small, shallow, and irregular elevations were noted.
  
  
  RESULTS
  An excisional biopsy was performed. The underlying cornea was markedly thinned, and fine ramifying vasculature was also noted on the exposed corneal stroma. Typical koilocytic change was observed on the histopathologic examination. Polymerase chain reaction revealed the existence of human papilloma virus type 6 DNA.
  
  
  CONCLUSIONS
  Here we describe a case of an isolated corneal papilloma-like lesion. Although the corneal extension of the limbal or the conjunctival papillomas has been commonly observed, an isolated corneal papilloma-like lesion with underlying stromal destruction has only rarely been reported.
authors.affiliation: Department of Ophthalmology, Dongguk University, Ilsan Hospital, Koyang, Kyunggido, South Korea. choulyong@yahoo.co.kr
authors.forename: Choul Yong
authors.initials: CY
authors.lastname: Park
authors.forename: Eo-Jin
authors.initials: EJ
authors.lastname: Kim
authors.forename: Jong Sun
authors.initials: JS
authors.lastname: Choi
authors.forename: Roy S
authors.initials: RS
authors.lastname: Chuck
mesh_terms: D003316:Corneal Diseases / Q000473:pathology / Q000601:surgery / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D015828:Eye Infections, Viral / Q000473:pathology / Q000601:surgery / Q000821:virology*; D005134:Eye Neoplasms / Q000473:pathology / Q000601:surgery / Q000821:virology*; D005260:Female; D052163:Human papillomavirus 6 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D010212:Papilloma / Q000473:pathology / Q000601:surgery / Q000821:virology*; D030361:Papillomavirus Infections / Q000473:pathology / Q000601:surgery / Q000821:virology*; D016133:Polymerase Chain Reaction; D014792:Visual Acuity
chemical_list: D004279:DNA, Viral