title: The management of portal hypertensive gastropathy and gastric antral vascular ectasia.
abstract: Portal hypertensive gastropathy and gastric antral vascular ectasia are gastric mucosal lesions that can cause chronic gastrointestinal haemorrhage and, consequently, chronic anaemia, in patients with cirrhosis. Although chronic anaemia is the most common clinical manifestation, these entities may also lead to acute gastrointestinal bleeding. Despite similar clinical manifestations, their pathophysiology and management are entirely different. Their diagnosis is endoscopic and although generally each of them has a characteristic endoscopic appearance and distribution, there are cases in which the differential is difficult and must rely on histology. This review focuses on the management of both entities. The mainstay of management of portal hypertensive gastropathy is based on portal-hypotensive pharmacological treatment whilst gastric antral vascular ectasia benefits from endoscopic therapy. More invasive options should be reserved for refractory cases.
authors.affiliation: Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ripoll
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Garcia-Tsao
mesh_terms: D057908:Argon Plasma Coagulation; D003937:Diagnosis, Differential; D020252:Gastric Antral Vascular Ectasia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D008103:Liver Cirrhosis / Q000150:complications; D013272:Stomach Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology