title: Nickel-catalyzed cross-coupling of potassium aryl- and heteroaryltrifluoroborates with unactivated alkyl halides.
abstract: A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp(3))-Br bonds in the presence of C(sp(2))-Br bonds was achieved.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA. gmolandr@sas.upenn.edu
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
authors.forename: O Andreea
authors.initials: OA
authors.lastname: Argintaru
authors.forename: Ioana
authors.initials: I
authors.lastname: Aron
authors.forename: Spencer D
authors.initials: SD
authors.lastname: Dreher
mesh_terms: D000478:Alkylation; D002384:Catalysis; D017611:Fluorine Compounds / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry*
chemical_list: D017611:Fluorine Compounds; D006219:Halogens; D009532:Nickel; D011188:Potassium