title: Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes.
abstract: The lipophilic ligand-bridged dinuclear cation Rubb₁₆ is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.
authors.affiliation: School of Physical, Environmental and Mathematical Sciences, University of New South Wales, Australian Defence Force Academy, Canberra, ACT 2600, Australia.
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Pisani
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Weber
authors.forename: Kirsten
authors.initials: K
authors.lastname: Heimann
authors.forename: J Grant
authors.initials: JG
authors.lastname: Collins
authors.forename: F Richard
authors.initials: FR
authors.lastname: Keene
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D007939:Leukemia L1210; D051379:Mice; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000633:toxicity*; D011725:Pyridines / Q000737:chemistry* / Q000633:toxicity; D012428:Ruthenium / Q000633:toxicity*
chemical_list: D009942:Organometallic Compounds; D011725:Pyridines; D012428:Ruthenium