title: Grand challenge commentary: Beyond discovery: probes that see, grab and poke.
abstract: Chemical biology is now able to discover molecules that manipulate virtually any biological target or process. It remains a grand challenge to leverage these molecules into useful probes that can be used to address unsolved problems in biology.
authors.affiliation: Department of Chemistry, Tufts University, Medford, Massachusetts, USA. joshua.kritzer@tufts.edu
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Kritzer
mesh_terms: D003585:Cell Biology; D004353:Drug Evaluation, Preclinical; D008024:Ligands; D015202:Protein Engineering; D017510:Protein Folding; D034741:RNA, Small Interfering / Q000737:chemistry; D054852:Small Molecule Libraries
chemical_list: D008024:Ligands; D034741:RNA, Small Interfering; D054852:Small Molecule Libraries