title: Femtosecond dynamics of a porphyrin derivative confined by the human serum albumin protein.
abstract: The relaxation dynamics of 5,10,15,20-tetrakis(4-hydroxyphenyl)-porphyrin (p-THPP) in tetrahydrofuran (THF) and encapsulated within the human serum albumin (HSA) protein in water solution was investigated. The protein environment affects the B→Q(y) and Q(x)→Q(y) transition dynamics (from 80 and 140-200 fs in THF to 50 and 100 fs in HSA, respectively) as well as the lifetime of the relaxed Q(x) state (9.1 vs 9.9 ns). The most prominent differences are observed in the relaxation dynamics in the hot Q(x) state in HSA, which includes the energy transfer to the protein in ∼1 ps and much slower solvent-assisted thermal equilibration component of about 20-30 ps.
authors.affiliation: Departamento de Química Física, Facultad de Ciencias Ambientales y Bioquimicas, and INAMOL, Campus Tecnológico de Toledo, Avenida Carlos III, S/N, Universidad de Castilla-La Mancha, 45071 Toledo, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Synak
authors.forename: Marcin
authors.initials: M
authors.lastname: Ziołek
authors.forename: Juan Angel
authors.initials: JA
authors.lastname: Organero
authors.forename: Abderrazzak
authors.initials: A
authors.lastname: Douhal
mesh_terms: D002214:Capsules / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D002214:Capsules; D011166:Porphyrins; D012709:Serum Albumin; D012996:Solutions; D014867:Water; C051232:5,10,15,20-tetra(4-hydroxyphenyl)porphyrin