title: Chromophobe renal cell carcinoma with sarcomatoid transformation in a dog.
abstract: A 12-year-old spayed female Siberian husky dog presented with hematuria and weight loss. An abdominal ultrasonographic examination revealed a left renal tumor measuring 8 cm in diameter, and a nephrectomy was performed. The resected kidney contained a cavitated tumor with a white solid region. Histologically, this tumor was composed of large polygonal cells with abundant and cloudy cytoplasm and focal sarcomatoid change. The neoplastic epithelial cells were reactive with colloidal iron staining; Dolichos biflorus agglutinin, peanut agglutinin, and Ulex europaeus agglutinin I lectins; and cluster of differentiation 10 and c-KIT antigens but not for periodic acid-Schiff or vimentin stain. Neoplastic sarcomatoid cells stained positive for vimentin. Because these histopathologic features are identical to those of human chromophobe renal cell carcinoma, the present case was diagnosed as canine chromophobe renal cell carcinoma.
authors.affiliation: Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, B252, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. t096022d@yokohama-cu.ac.jp
authors.forename: Naohito
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hironobu
authors.initials: H
authors.lastname: Murakami
authors.forename: Eriko
authors.initials: E
authors.lastname: Kagawa
authors.forename: Itirou
authors.initials: I
authors.lastname: Aoki
authors.forename: Yoji
authors.initials: Y
authors.lastname: Nagashima
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female