title: Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers.
abstract: This communication describes the development of conformationally constrained unnatural aromatic amino acids, constructed on rigid backbone wherein the carboxyl and amino groups project in two dimensions (planes) on the aromatic framework. Such a feature offers the possibility of design and development of conformationally ordered synthetic oligomers with intriguing structural architectures distinct from those classically observed. Furthermore, such amino acids will have the potential to extend the conformational space available for foldamer design with diverse backbone conformation and structural architectures.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
authors.forename: Veera V E
authors.initials: VV
authors.lastname: Ramesh
authors.forename: Arup
authors.initials: A
authors.lastname: Roy
authors.forename: Kuruppanthara N
authors.initials: KN
authors.lastname: Vijayadas
authors.forename: Amol M
authors.initials: AM
authors.lastname: Kendhale
authors.forename: Panchami
authors.initials: P
authors.lastname: Prabhakaran
authors.forename: Rajesh
authors.initials: R
authors.lastname: Gonnade
authors.forename: Vedavati G
authors.initials: VG
authors.lastname: Puranik
authors.forename: Gangadhar J
authors.initials: GJ
authors.lastname: Sanjayan
mesh_terms: D024322:Amino Acids, Aromatic / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D024322:Amino Acids, Aromatic