title: Collapsing glomerulopathy associated with proliferative lupus nephritis: reversible acute kidney injury.
abstract: Collapsing glomerulopathy is a rare form of glomerular injury, characterized by segmental or global collapse of the glomerular capillaries, wrinkling and retraction of the glomerular basement membrane, and marked hypertrophy and hyperplasia of podocytes. Prognosis is usually poor, with most cases developing end-stage renal disease, in spite of treatment. The association of collapsing glomerulopathy and systemic lupus erythematosus is very unusual. In this report, we describe the first case of a simultaneous diagnosis of collapsing glomerulopathy and diffuse proliferative lupus nephritis. The case presented with acute kidney injury and nephrotic syndrome and evolved with partial remission of nephrotic syndrome and recovery of renal function after aggressive treatment with intravenous cyclophosphamide and methylprednisolone.
authors.affiliation: Nephrology Division, University of Sao Paulo School of Medicine, Sao Paulo, Brazil. nataliamelo@ymail.com
authors.forename: N C V
authors.initials: NC
authors.lastname: Melo
authors.forename: D M A C
authors.initials: DM
authors.lastname: Malheiros
authors.forename: R T
authors.initials: RT
authors.lastname: Barros
authors.forename: V
authors.initials: V
authors.lastname: Woronik
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D007678:Kidney Glomerulus / Q000098:blood supply* / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones