title: The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila.
abstract: Stationary-to-migratory transitions of epithelial cells have a key role in development and tumour progression. Border cell migration is a powerful system in which to investigate this transition in living organisms. Here, we identify the Ste20-like kinase misshapen (msn) as a novel regulator of border-cell migration in Drosophila. Expression of msn in border cells is independent of the transcription factor slow border cells and of inputs from all pathways that are known to control border-cell migration. The msn gene functions to modulate the levels and/or distribution of Drosophila E-cadherin to promote the invasive migratory behaviour of border cells.
authors.affiliation: CABD, CSIC/Universidad Pablo de Olavide, Sevilla, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Cobreros-Reguera
authors.forename: Ana
authors.initials: A
authors.lastname: Fernández-Miñán
authors.forename: Cecilia H
authors.initials: CH
authors.lastname: Fernández-Espartero
authors.forename: Hernán
authors.initials: H
authors.lastname: López-Schier
authors.forename: Acaimo
authors.initials: A
authors.lastname: González-Reyes
authors.forename: María D
authors.initials: MD
authors.lastname: Martín-Bermudo
mesh_terms: D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D015820:Cadherins / Q000235:genetics; D002465:Cell Movement; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology* / Q000201:enzymology*; D004847:Epithelial Cells / Q000166:cytology* / Q000201:enzymology*; D005260:Female; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D010053:Ovary / Q000166:cytology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D000099193:rab11 GTP-Binding Proteins
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D015820:Cadherins; D029721:Drosophila Proteins; D048031:JNK Mitogen-Activated Protein Kinases; D017346:Protein Serine-Threonine Kinases; D020691:rab GTP-Binding Proteins; D000099193:rab11 GTP-Binding Proteins; C077246:slbo protein, Drosophila; C113875:msn protein, Drosophila