title: No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.
abstract: OBJECTIVE
  The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor.
  
  
  CONCLUSIONS
  Using data from a 2-year toxicology study of sibutramine in Sprague-Dawley CD rats and CD-1 mice, despite a dose-dependent reduction in food intake and body weight in rats compared with controls, and a body weight reduction in mice at the highest dose, there was no compelling evidence for reductions in mortality rate.
authors.affiliation: Department of Nutrition Sciences, University of Alabama at Birmingham, AL 35294, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Smith
authors.forename: H T
authors.initials: HT
authors.lastname: Robertson
authors.forename: R A
authors.initials: RA
authors.lastname: Desmond
authors.forename: T R
authors.initials: TR
authors.lastname: Nagy
authors.forename: D B
authors.initials: DB
authors.lastname: Allison
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D003503:Cyclobutanes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D009765:Obesity / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D015431:Weight Loss / Q000187:drug effects* / Q000502:physiology
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; D017367:Selective Serotonin Reuptake Inhibitors; C058254:sibutramine