title: Neurophysiological characterization of motor recovery in acute spinal cord injury.
abstract: METHODS
  Prospective cohort study.
  
  
  OBJECTIVE
  This study was designed to neurophysiologically characterize motor control recovery after spinal cord injury (SCI).
  
  
  METHODS
  University of Louisville, Louisville, Kentucky, USA.
  
  
  METHODS
  Eleven acute SCI admissions and five non-injured subjects were recruited for this study.
  
  
  METHODS
  The American Spinal Injury Association Impairment Scale (AIS) was used to categorize injury level and severity at onset. Multimuscle surface electromyography (sEMG) recording protocol of reflex and volitional motor tasks was initially performed between the day of injury and 11 days post onset (6.4±3.6, mean±s.d. days). Follow-up data were recorded for up to 17 months after injury. Initial AIS distribution was as follows: 4 AIS-A; 2 AIS-C; 5 AIS-D. Multimuscle activation patterns were quantified from the sEMG amplitudes of selected muscles using a vector-based calculation that produces separate values for the magnitude and similarity of SCI test-subject patterns to those of non-injured subjects for each task.
  
  
  RESULTS
  In SCI subjects, overall sEMG amplitudes were lower after SCI. Prime mover muscle voluntary recruitment was slower and multimuscle patterns were disrupted by SCI. Recovery occurred in 9 of the 11 subjects, showing an increase in sEMG amplitudes, more rapid prime mover muscle recruitment rates and the progressive normalization of the multimuscle activation patterns. The rate of increase was highly individualized, differing over time by limb and proximal or distal joint within each subject and across the SCI group.
  
  
  CONCLUSIONS
  Recovery of voluntary motor function can be quantitatively tracked using neurophysiological methods in the domains of time and multimuscle motor unit activation.
authors.affiliation: Norton Neuroscience Institute, Louisville, KY 40202, USA. barrymckay@earthlink.net
authors.forename: W B
authors.initials: WB
authors.lastname: McKay
authors.forename: A V
authors.initials: AV
authors.lastname: Ovechkin
authors.forename: T W
authors.initials: TW
authors.lastname: Vitaz
authors.forename: D G L
authors.initials: DG
authors.lastname: Terson de Paleville
authors.forename: S J
authors.initials: SJ
authors.lastname: Harkema
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care / Q000379:methods; D010243:Paralysis / Q000503:physiopathology* / Q000534:rehabilitation*; D020127:Recovery of Function / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000534:rehabilitation*; D015599:Trauma Severity Indices; D055815:Young Adult