title: SPINOL-derived phosphoric acids: synthesis and application in enantioselective Friedel-Crafts reaction of indoles with imines.
abstract: A new class of chiral phosphoric acids with spirobiindane as scaffold were conveniently synthesized from (S)-1,1'-spirobiindane-7,7'-diol ((S)-SPINOL) and employed to catalyze the asymmetric Friedel-Crafts reaction of indoles with imines to afford 3-indolyl methanamines. High yields (68-97%) and excellent enantioselectivities (up to 99% ee) were obtained.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Fangxi
authors.initials: F
authors.lastname: Xu
authors.forename: Dan
authors.initials: D
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Han
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.forename: Xufeng
authors.initials: X
authors.lastname: Lin
authors.forename: Yanguang
authors.initials: Y
authors.lastname: Wang