title: Magnetic microparticles based on natural polymers.
abstract: Magnetic micro- and nanoparticles based on ferrofluid (maghemite) were elaborated by inverse emulsion crosslinking of sodium salt of carboxymethylcellulose (CMCNa) and gelatin. Crosslinking was carried out with glutaric aldehyde within aqueous droplets dispersed into toluene in presence of surfactants. The influence of parameters such as the ratio of polymers and maghemite in the initial mixture on the composition, size, size dispersity, particle swelling and their ability for drug inclusion was studied. The ability to take-up drugs is directly correlated with the degree of swelling and gelatin content within the particles. Particle size is between tens of nanometers and a few microns. The magnetic properties of particles are demonstrated from saturation magnetization (between 43 and 44 emu g(-1)) when their superparamagnetic character was shown by the absence of hysteresis on the magnetization curve. Polymer-drug systems elaborated under particles keep their bactericide activity for at least 48 h. The absence of toxicity, associated with the bactericide activity, make these systems potential drug carriers.
authors.affiliation: Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, Technical University Gheorghe Asachi, 73, B Prof Dr doc Dimitrie Mangeron, 700050 IASI, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Tataru
authors.forename: M
authors.initials: M
authors.lastname: Popa
authors.forename: J
authors.initials: J
authors.lastname: Desbrieres
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry* / Q000633:toxicity; D002439:Cefotaxime / Q000737:chemistry / Q000494:pharmacology; D002592:Cetomacrogol / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers; D004339:Drug Compounding; D005290:Ferric Compounds / Q000737:chemistry* / Q000633:toxicity; D005780:Gelatin / Q000737:chemistry* / Q000633:toxicity; D005977:Glutarates / Q000737:chemistry; D006601:Hexoses / Q000737:chemistry; D007700:Kinetics; D007928:Lethal Dose 50; D008280:Magnetics; D053768:Metal Nanoparticles; D008727:Methotrexate / Q000737:chemistry; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D014050:Toluene / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000964:Antimetabolites, Antineoplastic; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005290:Ferric Compounds; D005977:Glutarates; D006601:Hexoses; D011136:Polysorbates; D012997:Solvents; D013501:Surface-Active Agents; C018665:sorbitan monooleate; C000499:ferric oxide; D014050:Toluene; D005780:Gelatin; D002592:Cetomacrogol; D002266:Carboxymethylcellulose Sodium; D002439:Cefotaxime; D008727:Methotrexate