title: Design and efficient synthesis of A-278637 derivatives as potential potassium channel opener.
abstract: A series of thieno[3,2-b]quinoline derivatives designed based on A-278637 scaffold, were synthesized efficiently via one-pot three-component reaction under solvent-free and catalyst-free conditions. This work provides a new compound library with potential biological activity for biomedical screening.
authors.affiliation: School of Chemistry and Chemical Engineering, Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou Normal University, Xuzhou, Jiangsu 221116, PR China.
authors.forename: Tuanjie
authors.initials: T
authors.lastname: Li
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Feng
authors.forename: Changsheng
authors.initials: C
authors.lastname: Yao
authors.forename: Chenxia
authors.initials: C
authors.lastname: Yu
authors.forename: Bei
authors.initials: B
authors.lastname: Jiang
authors.forename: Shujiang
authors.initials: S
authors.lastname: Tu
mesh_terms: D018360:Crystallography, X-Ray; D003499:Cyclic S-Oxides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D008968:Molecular Conformation; D015221:Potassium Channels / Q000819:agonists* / Q000378:metabolism; D015363:Quinolones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C466801:9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno(3,2-b)quinolin-8(4H)-one 1,1-dioxide; D003499:Cyclic S-Oxides; D015221:Potassium Channels; D015363:Quinolones