title: Moving dipoles method detects displacement in N2 and P3 generation in diffuse axonal injury patients.
abstract: Physiological neural mechanisms underlying attentional processes were investigated by means of moving dipoles method in survivors of diffuse axonal injury (DAI) and in a control group. N2 and P3 components were obtained by means of the administration of the Conner's Continuous Performance Test. Analysis of behavioral responses showed significant between-group differences in reaction times and error rates. A different number of dipoles was needed for the reconstruction of both N2 and P3 components in the two groups. The study of dipoles location revealed major displacements in damaged brains with respect to physiology. In conclusion, data from DAI patients showed that neuronal reorganization following brain injury evolves towards the generation of multiple central sources.
authors.affiliation: IIT Unit, Dipartimento di Bioingegneria, Politecnico di Milano, Italy. erika.molteni@polimi.it
authors.forename: Erika
authors.initials: E
authors.lastname: Molteni
authors.forename: Eleonora
authors.initials: E
authors.lastname: Gatti
authors.forename: Anna M
authors.initials: AM
authors.lastname: Bianchi
authors.forename: Sergio
authors.initials: S
authors.lastname: Cerutti
mesh_terms: D000465:Algorithms; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D020833:Diffuse Axonal Injury / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D005074:Evoked Potentials, Visual; D006801:Humans; D008959:Models, Neurological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity