title: Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design.
abstract: Influenza A virus is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. It has become increasingly evident that influenza viral infection is recognized by at least three classes of pattern-recognition receptors, including TLR-7, the retinoic acid inducible gene-I and nucleotide-binding domain and leucine-rich-repeat-containing protein 3, a member of the Nod-like receptor family. This article highlights the roles of different types of innate immune receptors in influenza virus immunity versus immunopathology.
authors.affiliation: Department of Virology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ichinohe@virology.med.kyushu-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ichinohe
mesh_terms: D002352:Carrier Proteins / Q000276:immunology*; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D011971:Receptors, Immunologic; D051199:Toll-Like Receptor 7 / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D007252:Influenza Vaccines; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D011971:Receptors, Immunologic; C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases