title: [Clinical use of D-dimer in patients with cancer].
abstract: There is a well-known close relationship between cancer and the haemostatic system. Plasma D-dimer (DD) is a marker of fibrin generation and lysis. In the clinical practice, its main use is in the diagnostic algorithms of venous thromboembolism (VTE), and it is one of the diagnostic criteria of disseminated intravacular coagulation. In patients with cancer, the specificity of DD is lower than in the general population, reducing its usefulness. However, there is a growing evidence that points out a possible application of DD in the clinical management of cancer patients as a predictor of VTE, marker of hidden cancer in patients with idiopathic VTE, or even as an independent prognostic factor of response to chemotherapy and survival. In this review, the current evidence supporting the use of DD in cancer patients is critically exposed and discussed.
authors.affiliation: Servicio de Hematología, Clínica Universidad de Navarra, Pamplona, Spain. rlecumber@unav.es
authors.forename: Ramón
authors.initials: R
authors.lastname: Lecumberri
authors.forename: Carlota
authors.initials: C
authors.lastname: Pegenaute
authors.forename: José A
authors.initials: JA
authors.lastname: Páramo
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000097:blood*; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D009363:Neoplasm Proteins / Q000097:blood*; D009369:Neoplasms / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000401:mortality; D009382:Neoplasms, Unknown Primary / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D012680:Sensitivity and Specificity; D019851:Thrombophilia / Q000097:blood / Q000209:etiology; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology
chemical_list: D014408:Biomarkers, Tumor; D005338:Fibrin Fibrinogen Degradation Products; D009363:Neoplasm Proteins; C036309:fibrin fragment D