title: Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions.
abstract: Organomicelles modified by surface dibenzylcyclooctyne moieties can conveniently be functionalized by strain-promoted alkyne-azide cycloadditions. The ligation approach is highly efficient, does not require toxic reagents and is compatible with a wide variety of functional modules. Interactions of proteins with surface ligands of the micelles have been studied by AFM, which revealed that it leads to disassembly of the particles thereby providing a mechanism for triggered drug release.
authors.affiliation: Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.forename: Guojun
authors.initials: G
authors.lastname: Chen
authors.forename: Xinghai
authors.initials: X
authors.lastname: Ning
authors.forename: Margreet A
authors.initials: MA
authors.lastname: Wolfert
authors.forename: Xiuru
authors.initials: X
authors.lastname: Li
authors.forename: Bingqian
authors.initials: B
authors.lastname: Xu
authors.forename: Geert-Jan
authors.initials: GJ
authors.lastname: Boons
mesh_terms: D001386:Azides / Q000737:chemistry*; D003500:Cyclization; D034242:Cyclooctanes / Q000737:chemistry*; D003516:Cycloparaffins / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008823:Micelles; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001386:Azides; D034242:Cyclooctanes; D003516:Cycloparaffins; D008823:Micelles; D011108:Polymers