title: Two cases of mycosis fungoides treated by reduced-intensity cord blood transplantation.
abstract: Mycosis fungoides is a cutaneous T-cell lymphoma, which is clinically divided into three stages: patch, plaque and tumor. Despite a variety of treatments the prognosis is poor in advanced mycosis fungoides. Recently, allogeneic hematopoietic stem cell transplantation has been successfully applied for such cases. We performed reduced-intensity umbilical cord blood transplantation for two advanced mycosis fungoides patients. Case 1 was a 56-year-old man and case 2 was a 30-year-old woman. Tumors of each case were refractory to conventional chemotherapy. Although radiation therapy was considerably effective, tumors relapsed after several months. Reduced-intensity umbilical cord blood transplantation was performed because case 1 had no human leukocyte antigen-identical siblings and the sibling of case 2 did not agree to be the donor. The male patient died of pulmonary failure 23 days after reduced-intensity umbilical cord blood transplantation. The case 2 patient succeeded in reduced-intensity umbilical cord blood transplantation and remained in complete/partial remission for 13 months. However, chemotherapy-resistant tumors relapsed, and allogeneic hematopoietic stem cell transplantation was performed at 17 months. She died of cerebral hemorrhage 23 days after the procedure. Reduced-intensity umbilical cord blood transplantation may be included in the treatments for advanced mycosis fungoides, where graft-versus-lymphoma effect seems to be a significant factor for the success of the treatment.
authors.affiliation: Department of Dermatology, Asahikawa Medical College, Hokkaido, Japan. ht948@asahikawa-med.ac.jp
authors.forename: Hitomi
authors.initials: H
authors.lastname: Tsuji
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
authors.forename: Masamoto
authors.initials: M
authors.lastname: Murakami
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kashiwagi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Akemi
authors.initials: A
authors.lastname: Ishida-Yamamoto
authors.forename: Junko
authors.initials: J
authors.lastname: Jimbo
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shindo
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sato
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kohgo
authors.forename: Hajime
authors.initials: H
authors.lastname: Iizuka
mesh_terms: D000328:Adult; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000473:pathology / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult