title: Device closure of patent ductus arteriosus in Marfan patients: safety and effect on the aortic root diameter.
abstract: OBJECTIVE
  There is little evidence in the medical literature about safety of PDA device closure and its effects on aortic root diameter in Marfan patients. We reported on nine Marfan patients whose ducts were occluded by coil or Amplatzer Duct Occluder.
  
  
  METHODS
  Two patients had aneurismal type E ducts which were closed by a single coil, respectively. The others had conical ducts for which even Amplatzer occluder, stiff, or double coils were used.
  
  
  RESULTS
  No untoward consequence was found during a median follow up period of 18.5 months (range 3 months to 6.33 years). Two patients had small residual shunts. The observed change in the mean ratio of aortic root diameter to its estimated value was statistically insignificant in seven patients who had complete data on their aortic root diameter before PDA closure and during the follow up.
  
  
  CONCLUSIONS
  We concluded that PDA device closure in Marfan patients is safe. Risk of residual shunt is higher even after closure of small ducts.
authors.affiliation: Division of Pediatric Cardiology, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Keyhan S
authors.initials: KS
authors.lastname: Zanjani
authors.forename: Abdul Rahim
authors.initials: AR
authors.lastname: Wong
authors.forename: Masood
authors.initials: M
authors.lastname: Sadiq
authors.forename: Howard S
authors.initials: HS
authors.lastname: Weber
authors.forename: Nancy G
authors.initials: NG
authors.lastname: Cutler
mesh_terms: D000293:Adolescent; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D002648:Child; D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007492:Iran; D008296:Malaysia; D008297:Male; D008382:Marfan Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D010154:Pakistan; D011474:Prosthesis Design; D018570:Risk Assessment; D055989:Septal Occluder Device; D012850:Sinus of Valsalva / Q000000981:diagnostic imaging*; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D014481:United States; D055815:Young Adult