title: Characterization of CdHgTe/CdS QDs for near infrared fluorescence imaging of spinal column in a mouse model.
abstract: Near infrared (NIR) CdHgTe/CdS quantum dots (QDs) were successfully prepared by a green synthetic route. The characteristics such as morphology, size, spectra, stability and toxicity were investigated in detail. The fluorescence wavelength of CdHgTe/CdS QDs could be adjusted to the NIR range (812nm), which made the in vivo NIR imaging possible. The in vivo dynamic biodistribution of CdHgTe/CdS QDs in a mouse model was monitored by an NIR imaging system. Results indicated that CdHgTe/CdS QDs with a diameter of about 5.8nm targeted to spinal column effectively. Further imaging of the dissected spine disclosed that QDs targeted to vertebra rather than spinal cord. The high fluorescence intensity together with targeting effect makes CdHgTe/CdS QDs particular candidates for imaging purposes in experimental animal models of vertebral injury.
authors.affiliation: Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Sisi
authors.initials: S
authors.lastname: Cui
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Tu
authors.forename: Jinzi
authors.initials: J
authors.lastname: Ji
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Gu
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry*; D017669:Mercury Compounds / Q000737:chemistry*; D051379:Mice; D023421:Models, Animal; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared; D013131:Spine / Q000033:anatomy & histology*
chemical_list: D019187:Cadmium Compounds; D017669:Mercury Compounds; D018036:Selenium Compounds; C104191:mercury cadmium telluride; C058667:cadmium selenide