title: Reconsidering fetal and neonatal alloimmune thrombocytopenia with a focus on screening and prevention.
abstract: Uncertainty regarding the pathophysiology of fetal and neonatal alloimmune thrombocytopenia (FNAIT) has hampered the decision regarding how to identify, follow-up and treat the women and children with this potentially serious condition. Since knowledge of the condition is derived mainly from retrospective studies, understanding of the natural history of this condition remains incomplete. General screening programs for FNAIT have still not been introduced, mainly because of a lack of reliable risk factors and effective treatment. Now, several prospective screening studies involving up to 100,000 pregnant women have been published and the results have changed the understanding of the pathophysiology of FNAIT and, thereby, the approach toward diagnostics, prevention and treatment in a more appropriate way.
authors.affiliation: Laboratory Medicine, University Hospital of North Norway, N-9038 Tromsø, Norway. bjorn.skogen@unn.no
authors.forename: Bjørn
authors.initials: B
authors.lastname: Skogen
authors.forename: Mette Kjær
authors.initials: MK
authors.lastname: Killie
authors.forename: Jens
authors.initials: J
authors.lastname: Kjeldsen-Kragh
authors.forename: Maria Therese
authors.initials: MT
authors.lastname: Ahlen
authors.forename: Heidi
authors.initials: H
authors.lastname: Tiller
authors.forename: Tor B
authors.initials: TB
authors.lastname: Stuge
authors.forename: Anne
authors.initials: A
authors.lastname: Husebekk
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology; D015415:Biomarkers; D002648:Child; D005260:Female; D005333:Fetus / Q000276:immunology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D039661:Integrin beta3; D020300:Intracranial Hemorrhages / Q000503:physiopathology; D007518:Isoantibodies / Q000276:immunology*; D015997:Neonatal Screening; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy
chemical_list: D016824:Antigens, Human Platelet; D015415:Biomarkers; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies