title: Electrochemical determination of antihypertensive drug irbesartan in pharmaceuticals.
abstract: A sensitive voltammetric method has been developed for the determination of irbesartan in a Britton-Robinson buffer medium. Irbesartan exhibited a well-defined cathodic peak over the entire pH range from 2.0 to 12.0. The mechanism of reduction was postulated on the basis of controlled potential electrolysis, coulometry, and spectral analysis. Under optimal conditions, a linear response of irbesartan was obtained in the range from 3.0 × 10(-5) to 5.7 × 10(-3)molL(-1) and with a limit of detection of 5.33 × 10(-7)molL(-1). The effect of cationic surfactant on the voltammetric reduction peak of irbesartan in Britton-Robinson buffer is also described.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India. vinodfcy@iitr.ernet.in
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Gupta
authors.forename: Rajeev
authors.initials: R
authors.lastname: Jain
authors.forename: Shilpi
authors.initials: S
authors.lastname: Agarwal
authors.forename: Ritesh
authors.initials: R
authors.lastname: Mishra
authors.forename: Ashish
authors.initials: A
authors.lastname: Dwivedi
mesh_terms: D000959:Antihypertensive Agents / Q000032:analysis / Q000737:chemistry; D001713:Biphenyl Compounds / Q000032:analysis* / Q000737:chemistry*; D002412:Cations / Q000032:analysis* / Q000737:chemistry*; D003217:Conductometry / Q000379:methods; D004304:Dosage Forms / Q000592:standards; D004355:Drug Stability; D055664:Electrochemical Techniques / Q000379:methods*; D004572:Electrolysis / Q000379:methods; D006863:Hydrogen-Ion Concentration; D000077405:Irbesartan; D004364:Pharmaceutical Preparations / Q000737:chemistry; D012680:Sensitivity and Specificity; D013501:Surface-Active Agents / Q000737:chemistry; D013777:Tetrazoles / Q000032:analysis* / Q000737:chemistry*
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D002412:Cations; D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D013501:Surface-Active Agents; D013777:Tetrazoles; D000077405:Irbesartan