title: In vitro activity of N-chlorotaurine (NCT) in combination with NH4Cl against Trichomonas vaginalis.
abstract: Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is usually treated with metronidazole, however resistance is on the rise. In this study, N-chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use, killed T. vaginalis in vitro within 15 min of treatment at a concentration of 55 mM (1%), which is well tolerated by human tissue. The activity of NCT was further enhanced by addition of ammonium chloride (NH(4)Cl). A combination of 5.5 mM (0.1%) NCT plus 19 mM (0.1%) NH(4)Cl killed 100% of trichomonads within 5 min.
authors.affiliation: Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
authors.forename: Ursula
authors.initials: U
authors.lastname: Fürnkranz
authors.forename: Markus
authors.initials: M
authors.lastname: Nagl
authors.forename: Waldemar
authors.initials: W
authors.lastname: Gottardi
authors.forename: Michael
authors.initials: M
authors.lastname: Duchêne
authors.forename: Horst
authors.initials: H
authors.lastname: Aspöck
authors.forename: Julia
authors.initials: J
authors.lastname: Walochnik
mesh_terms: D000643:Ammonium Chloride / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D000643:Ammonium Chloride; D013654:Taurine; C043410:N-chlorotaurine