title: [The influence of fluoxetine on noradrenergetic neurotransmitters of brain cortex].
abstract: The aim of this work was to evaluate the hypothesis that the second-generation antidepressant, might play a role in controlling the activity of noradrenalergic neurotransmitters. The paper details the pharmacological profile of antidepressant drug Fluoxetive with high affinity for 5-HT receptor, and explains how the antidepressant activity chances noradrenalin reuptake inhibitor-medications. Brain cortexes of 20 rabbits were analyzed by high-performance liquid chromatography. The conducted quantitative and qualitative analyzes show that antidepressant activity of Fluoxetine could be mediated by the synergistic effects on the serotoninergic and noradrenergic receptor pathways. Major depressive disorders are heterogeneous monoamine condition. Our studies have demonstrated fluoxetine efficacy and safety for treatment of major depressive disorders.
authors.forename: D Z
authors.initials: DZ
authors.lastname: Zurabashvili
authors.forename: I B
authors.initials: IB
authors.lastname: Giorgobiani
authors.forename: M A
authors.initials: MA
authors.lastname: Arveladze
authors.forename: I A
authors.initials: IA
authors.lastname: Gamkrelidze
authors.forename: E N
authors.initials: EN
authors.lastname: Kavsadze
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D005473:Fluoxetine / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D009638:Norepinephrine; D017367:Selective Serotonin Reuptake Inhibitors