title: Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients.
abstract: The association between angiotensin-converting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.
authors.affiliation: Department of Medical Sciences, Geriatric Unit and Gerontology-Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, Foggia, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Seripa
authors.forename: Giulia
authors.initials: G
authors.lastname: Paroni
authors.forename: Maria G
authors.initials: MG
authors.lastname: Matera
authors.forename: Carolina
authors.initials: C
authors.lastname: Gravina
authors.forename: Carlo
authors.initials: C
authors.lastname: Scarcelli
authors.forename: Michele
authors.initials: M
authors.lastname: Corritore
authors.forename: Luigi P
authors.initials: LP
authors.lastname: D'Ambrosio
authors.forename: Maria
authors.initials: M
authors.lastname: Urbano
authors.forename: Grazia
authors.initials: G
authors.lastname: D'Onofrio
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Copetti
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Kehoe
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
authors.forename: Alberto
authors.initials: A
authors.lastname: Pilotto
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D015577:Geriatric Assessment; D006760:Hospitalization; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D007703:Peptidyl-Dipeptidase A