title: Polyurethane/dermatan sulfate copolymers as hemocompatible, non-biofouling materials.
abstract: The range of application of polyurethanes has been limited by their poor hemocompatibility and inability to resist non-specific binding of biomolecules and cells. In this work, a non-adhesive PU-based material was synthesized via the copolymerization of PU with dermatan sulfate. Incorporation of DS into the PU backbone dramatically increased material hydrophilicity and decreased protein adsorption. The in vitro adhesion of several cell types, including platelets, also significantly decreased with increasing DS content. Both the physical and biological properties of the DS contributed to the anti-adhesive properties of the PU/DS copolymer, and this anti-adhesive nature of PU/DS renders this new biomaterial attractive for blood-contacting or non-fouling applications.
authors.affiliation: Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Fangmin
authors.initials: F
authors.lastname: Xu
authors.forename: Claire E
authors.initials: CE
authors.lastname: Flanagan
authors.forename: Amaliris
authors.initials: A
authors.lastname: Ruiz
authors.forename: Wendy C
authors.initials: WC
authors.lastname: Crone
authors.forename: Kristyn S
authors.initials: KS
authors.lastname: Masters
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D001672:Biocompatible Materials / Q000494:pharmacology*; D057219:Biofouling / Q000517:prevention & control*; D002448:Cell Adhesion / Q000187:drug effects; D002850:Chromatography, Gel; D004247:DNA / Q000378:metabolism; D003871:Dermatan Sulfate / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008970:Molecular Weight; D041681:NIH 3T3 Cells; D010973:Platelet Adhesiveness / Q000187:drug effects; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013314:Stress, Mechanical; D013499:Surface Properties / Q000187:drug effects; D013816:Thermodynamics
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; D003871:Dermatan Sulfate; D004247:DNA