title: Synthesis of 6-trifluoromethylindolo[1,2-c]quinazolines and related heterocycles using N-(2-iodophenyl)trifluoroacetimidoyl chlorides as starting material via C-H bond functionalization.
abstract: A mild, two-step reaction for the synthesis of 6-trifluoromethylindolo[1,2-c]quinazolines from readily available indoles and N-(2-iodophenyl)trifluoroacetimidoyl chlorides via addition-elimination/arylation is described. An array of aza-fused trifluoromethylated heterocycles can be easily assembled via Friedel-Crafts reaction/C-H bond activation by this methodology.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling, Road, Shanghai 200032, China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Zhu
authors.forename: Haibo
authors.initials: H
authors.lastname: Xie
authors.forename: Zixian
authors.initials: Z
authors.lastname: Chen
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Yongming
authors.initials: Y
authors.lastname: Wu
mesh_terms: D002244:Carbon / Q000737:chemistry* / Q000378:metabolism; D002712:Chlorides / Q000737:chemistry* / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000378:metabolism; D006859:Hydrogen / Q000737:chemistry* / Q000378:metabolism; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D002712:Chlorides; D006571:Heterocyclic Compounds; D007211:Indoles; D011799:Quinazolines; D002244:Carbon; D006859:Hydrogen