title: Effects of platelet-rich plasma on sinus bone graft: meta-analysis.
abstract: BACKGROUND
  This meta-analysis investigates the effects of platelet-rich plasma (PRP) on the sinus bone graft.
  
  
  METHODS
  PubMed, the Cochrane Library, and EMBASE were searched in January 2010.
  
  
  RESULTS
  Of 61 articles searched, eight controlled clinical trials, which included a total of 352 sinus bone graft cases in 191 patients, were included in the final analysis. In the fixed-effects meta-analysis, the implant survival was not significantly different between two groups in the patient-based data of four studies (relative risk [RR]: 1.02; 95% confidence interval [CI]: 0.97 to 1.08) and in the implant-based data of three studies (RR: 1.02; 95% CI: 0.99 to 1.04). The bone formation was significantly greater in the intervention group in the random-effects model (standardized mean difference [SMD]: 1.30; 95% CI: 0.21 to 2.39) in five studies with significant heterogeneity (I(2) = 76.2%). The bone-to-implant contact was not significantly different between two groups in the random-effects model (SMD: 1.02; 95% CI: -1.65 to 3.70) in two studies with significant heterogeneity (I(2) = 82.4%).
  
  
  CONCLUSIONS
  The present study indicates that there was sufficient evidence to support the use of PRP for bone formation on a sinus bone graft, whereas there was no significant effect on the implant survival and bone-to-implant contact.
authors.affiliation: Department of Conservative Dentistry, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Bae
authors.forename: Young-Kyun
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Kwon
authors.initials: SK
authors.lastname: Myung
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D018849:Controlled Clinical Trials as Topic; D015921:Dental Implants; D006801:Humans; D008437:Maxilla / Q000601:surgery; D008443:Maxillary Sinus / Q000601:surgery*; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D053657:Platelet-Rich Plasma; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis
chemical_list: D015921:Dental Implants