title: PCRPi-DB: a database of computationally annotated hot spots in protein interfaces.
abstract: Protein-protein interactions are central to almost any cellular process. Although typically protein interfaces are large, it is well established that only a relatively small region, the so-called 'hot spot', contributes the most to the total binding energy. There is a clear interest in identifying hot spots because of its application in drug discovery and protein design. Presaging Critical Residues in Protein Interfaces Database (PCRPi-DB) is a public repository that archives computationally annotated hot spots in protein complexes for which the 3D structure is known. Hot spots have been annotated using a new and highly accurate computational method developed in the lab. PCRPi-DB is freely available to the scientific community at http://www.bioinsilico.org/PCRPIDB. Besides browsing and querying the contents of the database, extensive documentation and links to relevant on-line resources and contents are available to users. PCRPi-DB is updated on a weekly basis.
authors.affiliation: Section of Experimental Therapeutics, Leeds Institute of Molecular Medicine, St James's University Hospital, University of Leeds, Leeds LS9 7TF, UK.
authors.forename: Joan
authors.initials: J
authors.lastname: Segura
authors.forename: Narcis
authors.initials: N
authors.lastname: Fernandez-Fuentes
mesh_terms: D000465:Algorithms; D001426:Bacterial Proteins / Q000737:chemistry; D019295:Computational Biology; D030562:Databases, Protein; D058977:Molecular Sequence Annotation; D046912:Multiprotein Complexes / Q000737:chemistry*; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D001618:beta-Lactamases / Q000737:chemistry
chemical_list: D001426:Bacterial Proteins; D046912:Multiprotein Complexes; C065596:beta-lactamase-inhibitor protein, Streptomyces; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1