title: The telomere protein tankyrase 1 regulates DNA damage responses at telomeres.
abstract: The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates DNA damage responses at telomeres.
authors.forename: Sandy
authors.initials: S
authors.lastname: Chang
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology; D004260:DNA Repair / Q000502:physiology*; D051747:DNA-Activated Protein Kinase / Q000378:metabolism; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000502:physiology; D012854:Sister Chromatid Exchange / Q000502:physiology; D038501:Tankyrases / Q000502:physiology*; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
chemical_list: D051747:DNA-Activated Protein Kinase; D009687:Nuclear Proteins; D046988:Proteasome Endopeptidase Complex; D038501:Tankyrases; C418109:TNKS protein, human; C497263:PRKDC protein, human