title: Integrin signalling adaptors: not only figurants in the cancer story.
abstract: Current evidence highlights the ability of adaptor (or scaffold) proteins to create signalling platforms that drive cellular transformation upon integrin-dependent adhesion and growth factor receptor activation. The understanding of the biological effects that are regulated by these adaptors in tumours might be crucial for the identification of new targets and the development of innovative therapeutic strategies for human cancer. In this Review we discuss the relevance of adaptor proteins in signalling that originates from integrin-mediated cell-extracellular matrix (ECM) adhesion and growth factor stimulation in the context of cell transformation and tumour progression. We specifically underline the contribution of p130 Crk-associated substrate (p130CAS; also known as BCAR1), neural precursor cell expressed, developmentally down-regulated 9 (NEDD9; also known as HEF1), CRK and the integrin-linked kinase (ILK)-pinch-parvin (IPP) complex to cancer, along with the more recently identified p140 Cas-associated protein (p140CAP; also known as SRCIN1).
authors.affiliation: Molecular Biotechnology Centre and Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, Torino 10126, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Cabodi
authors.forename: Maria
authors.initials: M
authors.lastname: del Pilar Camacho-Leal
authors.forename: Paola
authors.initials: P
authors.lastname: Di Stefano
authors.forename: Paola
authors.initials: P
authors.lastname: Defilippi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D033942:Adaptor Proteins, Vesicular Transport / Q000502:physiology; D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D006801:Humans; D016023:Integrins / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000209:etiology*; D010750:Phosphoproteins / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D050737:Proto-Oncogene Proteins c-crk / Q000502:physiology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D000099200:Scaffold Protein ILK
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D016023:Integrins; D010750:Phosphoproteins; D017346:Protein Serine-Threonine Kinases; D050737:Proto-Oncogene Proteins c-crk; D018719:Erb-b2 Receptor Tyrosine Kinases; D016212:Transforming Growth Factor beta; D000099200:Scaffold Protein ILK; C485285:CRK protein, human; C099942:NEDD9 protein, human; C532615:SRCIN1 protein, human; C508053:ERBB2 protein, human