title: Spatiotemporal dynamics of the Calvin cycle: multistationarity and symmetry breaking instabilities.
abstract: The possibility of controlling the Calvin cycle has paramount implications for increasing the production of biomass. Multistationarity, as a dynamical feature of systems, is the first obvious candidate whose control could find biotechnological applications. Here we set out to resolve the debate on the multistationarity of the Calvin cycle. Unlike the existing simulation-based studies, our approach is based on a sound mathematical framework, chemical reaction network theory and algebraic geometry, which results in provable results for the investigated model of the Calvin cycle in which we embed a hierarchy of realistic kinetic laws. Our theoretical findings demonstrate that there is a possibility for multistationarity resulting from two sources, homogeneous and inhomogeneous instabilities, which partially settle the debate on multistability of the Calvin cycle. In addition, our tractable analytical treatment of the bifurcation parameters can be employed in the design of validation experiments.
authors.affiliation: Institute of Biochemistry and Biology, University of Potsdam, Germany.
authors.forename: Sergio
authors.initials: S
authors.lastname: Grimbs
authors.forename: Anne
authors.initials: A
authors.lastname: Arnold
authors.forename: Aneta
authors.initials: A
authors.lastname: Koseska
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kurths
authors.forename: Joachim
authors.initials: J
authors.lastname: Selbig
authors.forename: Zoran
authors.initials: Z
authors.lastname: Nikoloski
mesh_terms: D018533:Biomass; D001709:Biotechnology / Q000379:methods*; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological; D010788:Photosynthesis / Q000502:physiology*