title: Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
abstract: Aging is associated with the functional decline of cells, tissues, and organs. At the same time, age is the single most important prognostic factor in the development of most human cancers, including chronic myelogenous and acute lymphoblastic leukemias initiated by Bcr-Abl oncogenic translocations. Prevailing paradigms attribute the association between aging and cancers to the accumulation of oncogenic mutations over time, because the accrual of oncogenic events is thought to be the rate-limiting step in initiation and progression of cancers. Conversely, aging-associated functional decline caused by both cell-autonomous and non-cell-autonomous mechanisms is likely to reduce the fitness of stem and progenitor cell populations. This reduction in fitness should be conducive for increased selection of oncogenic mutations that can at least partially alleviate fitness defects, thereby promoting the initiation of cancers. We tested this hypothesis using mouse hematopoietic models. Our studies indicate that the dramatic decline in the fitness of aged B-lymphopoiesis coincides with altered receptor-associated kinase signaling. We further show that Bcr-Abl provides a much greater competitive advantage to old B-lymphoid progenitors compared with young progenitors, coinciding with restored kinase signaling pathways, and that this enhanced competitive advantage translates into increased promotion of Bcr-Abl-driven leukemias. Moreover, impairing IL-7-mediated signaling is sufficient to promote selection for Bcr-Abl-expressing B progenitors. These studies support an unappreciated causative link between aging and cancer: increased selection of oncogenic mutations as a result of age-dependent alterations of the fitness landscape.
authors.affiliation: Department of Biochemistry and Molecular Genetics and Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Henry
authors.forename: Andriy
authors.initials: A
authors.lastname: Marusyk
authors.forename: Vadym
authors.initials: V
authors.lastname: Zaberezhnyy
authors.forename: Biniam
authors.initials: B
authors.lastname: Adane
authors.forename: James
authors.initials: J
authors.lastname: DeGregori
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D016026:Bone Marrow Transplantation; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000378:metabolism; D056084:Genetic Fitness; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D015851:Interleukin-7 / Q000378:metabolism; D007938:Leukemia / Q000503:physiopathology*; D038041:Lymphopoiesis / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology*
chemical_list: D015851:Interleukin-7; D016044:Fusion Proteins, bcr-abl