title: IL-6 -174G>C polymorphism and cancer risk: a meta-analysis involving 29,377 cases and 37,739 controls.
abstract: Interleukin-6 (IL-6) is a multifunctional cytokine involved in different physiologic and pathophysiologic processes and plays important roles in the etiology of cancer. The -174G>C polymorphism of the IL-6 gene influences IL-6 transcription and has been implicated in cancer risk. However, published data have been conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 29,377 cancer cases and 37,739 controls from 50 published case-control studies was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association between -174G>C polymorphism and cancer risk. Overall meta-analysis indicated that no association was found between -174G>C genotypes and cancer risk. However, the positive association was found in bladder cancer (OR=4.33, 95% CI: 1.93-9.71 for CC vs. GC, OR=2.81, 95% CI: 1.39-5.68 for CC vs. GG, and OR=2.19, 95% CI: 1.32-3.64 for CC vs. GG/GC), and among Asians (OR=2.08, 95% CI: 1.07-4.06 for CC vs. GG, and OR=2.20, 95% CI: 1.02-4.74 for CC vs. GG/GC) and Africans (OR=1.61, 95% CI: 1.07-2.42 for GC vs. GG). This meta-analysis showed the evidence that the -174G>C of the IL-6 gene was a low-penetrance susceptibility gene for bladder cancer. Further larger, preferably prospective studies are needed to confirm this relationship.
authors.affiliation: Department of Urology, Laboratory of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Niu
authors.forename: Zi-Dun
authors.initials: ZD
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Mi
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Min
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.forename: Peng-Chao
authors.initials: PC
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Wu
authors.forename: Zheng-Dong
authors.initials: ZD
authors.lastname: Zhang
authors.forename: Zeng-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Hua
authors.forename: Ning-Han
authors.initials: NH
authors.lastname: Feng
authors.forename: Xin-Ru
authors.initials: XR
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D015850:Interleukin-6