title: Effect of β tricalcium phosphate particle size on recombinant human platelet-derived growth factor-BB-induced regeneration of periodontal tissue in dog.
abstract: The aim of this study was to investigate the effect of β tricalcium phosphate (β-TCP) particle size on recombinant human platelet-derived growth factor-BB (rhPDGF-BB)-induced regeneration of periodontal tissue in dog. The control group (rhPDGF-BB alone) was characterized by incomplete, newly formed bone. The large-particle β-TCP (L-TCP(O))/rhPDGF-BB group showed a statistically significant increase in both new bone and cementum formation compared to the small-particle β-TCP (S-TCP(G))/rhPDGF-BB group. These findings suggest that L-TCP(O)-particle promotes rhPDGF-BB-induced formation of bone and cementum.
authors.affiliation: Department of Periodontology, Tokyo Dental College, Chiba, Japan. dirokawa@tdc.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Irokawa
authors.forename: Mikio
authors.initials: M
authors.lastname: Ota
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shibukawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D016301:Alveolar Bone Loss / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D000077214:Becaplermin; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D025021:Cementogenesis / Q000187:drug effects; D003739:Dental Cementum / Q000473:pathology; D004285:Dogs; D005347:Fibroblasts / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis / Q000187:drug effects; D010316:Particle Size; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D016062:Porosity; D020574:Proto-Oncogene Proteins c-sis; D011897:Random Allocation; D011994:Recombinant Proteins; D013524:Surgical Flaps; D000071681:Tartrate-Resistant Acid Phosphatase; D014961:X-Ray Diffraction
chemical_list: D043925:Angiogenesis Inducing Agents; D001672:Biocompatible Materials; D015415:Biomarkers; D018786:Bone Substitutes; D002130:Calcium Phosphates; D007527:Isoenzymes; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; C485817:beta-tricalcium phosphate; D000077214:Becaplermin; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase