title: Tuning in to noise: epigenetics and intangible variation.
abstract: In this special issue of Developmental Cell, we discuss the role of chromatin in phenotypic variation as a counterpoint to the reviews on chromatin dynamics in development and cancer. We highlight some recent work on the role of chromatin in transcriptional noise in yeast and Caenorhabditis elegans and consider the implications in understanding intangible variation or developmental noise in mammals.
authors.affiliation: Epigenetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.
authors.forename: Nadia C
authors.initials: NC
authors.lastname: Whitelaw
authors.forename: Suyinn
authors.initials: S
authors.lastname: Chong
authors.forename: Emma
authors.initials: E
authors.lastname: Whitelaw
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D002843:Chromatin / Q000378:metabolism*; D044127:Epigenesis, Genetic; D014644:Genetic Variation; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics
chemical_list: D002843:Chromatin