title: Recurrent alveolar rhabdomyosarcoma with prior surgery and radiotherapy: altered lymphatic drainage limits the reliability of sentinel lymph node biopsy.
abstract: A 7-year-old girl was diagnosed with alveolar rhabdomyosarcomas of the right crural region. The patient was initially treated with chemotherapy and surgery with wide surgical margins, with radiotherapy. The tumors relapsed in the popliteal region surrounding the popliteal vessels. The patient received sentinel lymph node biopsy for a recurrent tumor using isosulfan blue dye, with the "sentinel node" being malignant-negative, and a "nonsentinel node" positive. Sentinel lymph node biopsy with conventional blue dye alone might be insufficient to assess lymph node status in patients with recurrent rhabdomyosarcoma previously treated with surgery and/or radiotherapy.
authors.affiliation: Department of Orthopaedic Surgery, Nagoya University Graduate School, Showa, Nagoya, Japan. ynishida@med.nagoya-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsukushi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Shimoyama
authors.forename: Yoji
authors.initials: Y
authors.lastname: Shido
authors.forename: Junji
authors.initials: J
authors.lastname: Wasa
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiguro
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000503:physiopathology*; D012008:Recurrence; D018232:Rhabdomyosarcoma, Alveolar / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery*; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*