title: Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
abstract: A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. sriram_tyagarajan@merck.com
authors.forename: Sriram
authors.initials: S
authors.lastname: Tyagarajan
authors.forename: Prasun K
authors.initials: PK
authors.lastname: Chakravarty
authors.forename: Bishan
authors.initials: B
authors.lastname: Zhou
authors.forename: Brett
authors.initials: B
authors.lastname: Taylor
authors.forename: Ronsar
authors.initials: R
authors.lastname: Eid
authors.forename: Michael H
authors.initials: MH
authors.lastname: Fisher
authors.forename: William H
authors.initials: WH
authors.lastname: Parsons
authors.forename: Mathew J
authors.initials: MJ
authors.lastname: Wyvratt
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Lyons
authors.forename: Tracy
authors.initials: T
authors.lastname: Klatt
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Li
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
authors.forename: Brande
authors.initials: B
authors.lastname: Williams
authors.forename: John
authors.initials: J
authors.lastname: Felix
authors.forename: Birgit T
authors.initials: BT
authors.lastname: Priest
authors.forename: Richard M
authors.initials: RM
authors.lastname: Brochu
authors.forename: Vivien
authors.initials: V
authors.lastname: Warren
authors.forename: McHardy
authors.initials: M
authors.lastname: Smith
authors.forename: Maria
authors.initials: M
authors.lastname: Garcia
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Kaczorowski
authors.forename: William J
authors.initials: WJ
authors.lastname: Martin
authors.forename: Catherine
authors.initials: C
authors.lastname: Abbadie
authors.forename: Erin
authors.initials: E
authors.lastname: McGowan
authors.forename: Nina
authors.initials: N
authors.lastname: Jochnowitz
authors.forename: Ann
authors.initials: A
authors.lastname: Weber
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Duffy
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D009437:Neuralgia / Q000188:drug therapy*; D011720:Pyrazoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D051381:Rats; D026941:Sodium Channel Blockers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D015222:Sodium Channels / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001713:Biphenyl Compounds; D011720:Pyrazoles; D026941:Sodium Channel Blockers; D015222:Sodium Channels