title: Desmoplastic ganglioglioma of the spinal cord in a western European hedgehog (Erinaceus europaeus).
abstract: Gangliogliomas are composed of neoplastic glial and neuronal cells and are extremely rare tumors of the central nervous system of domestic animals. The present report describes the clinical presentation and the pathomorphological and immunophenotypical characteristics of a desmoplastic ganglioglioma in the spinal cord of a 3-year-old male western European hedgehog (Erinaceus europaeus). Clinically, the hedgehog exhibited a skin wound and therapy-resistant paresis of the left hind limb. Necropsy showed dilatation of the urinary bladder. Histologic examination of the thoracic spinal cord revealed a focally extensive infiltrative mass, which consisted of multiple nodules of smaller bipolar or oligopolar glial cells and variably sized polygonal, ganglionic, neuron-like cells embedded in variable amounts of microcystic neuropilic matrix. An area of spindle-shaped cells arranged in interwoven fascicles and surrounded by a prominent network of reticulin fibers was interpreted as desmoplastic leptomeningeal stroma. Immunohistochemistry revealed a moderate number of glial fibrillary acidic protein and S-100-positive cells and processes. In addition, the ganglionic neuron-like cells expressed neurofilament, microtubule-associated protein-2, and neuron-specific enolase. In summary, this spinal cord tumor was composed of astroglial and neuronal cellular elements, justifying the diagnosis of a desmoplastic ganglioglioma.
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany. reiner.ulrich@tiho-hannover.de
authors.forename: Reiner
authors.initials: R
authors.lastname: Ulrich
authors.forename: Alexandru C
authors.initials: AC
authors.lastname: Stan
authors.forename: Michael
authors.initials: M
authors.lastname: Fehr
authors.forename: Carolin
authors.initials: C
authors.lastname: Mallig
authors.forename: Christina
authors.initials: C
authors.lastname: Puff
mesh_terms: D000818:Animals; D018303:Ganglioglioma / Q000145:classification / Q000662:veterinary*; D006364:Hedgehogs; D008297:Male; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*