title: Quality of intertrochanteric cancellous bone as predictor of femoral stem RSA migration in cementless total hip arthroplasty.
abstract: In cementless total hip arthroplasty, osteoporosis may jeopardize the achievement of immediate stability and lead to migration of anatomically shaped femoral stems. Poor quality of proximal cancellous bone per se may also affect the rate of osseointegration. In a selected group of female total hip arthroplasty patients (mean age 64 years) with unremarkable medical history, intertrochanteric cancellous bone biopsy was taken from the site of stem implantation. Local bone quality, determined by structural μCT imaging and destructive compression testing of the biopsy tissue, was used as the predictor of three-dimensional stem migration determined by radiostereometric analysis (RSA) up to 24 months. The patients exhibited major differences in mechanical properties of the intertrochanteric cancellous bone, which were closely related to the structural parameters calculated from μCT data. Unexpectedly, the major differences observed in the quality of trochanteric cancellous bone had only minor reflections in the RSA migration of the femoral stems. In statistical analysis, the μCT-based bone mineral density quartile (low, middle, high) was the only significant predictor for stem translation at 24 months (p=0.022) but only a small portion (R(2)=0.16) of the difference in translation could be explained by changes in bone mineral density quartile. None of the other parameters investigated predicted stem migration in translation or rotation. In conclusion, poor quality of intertrochanteric cancellous bone seems to contribute to the risk of implant migration less than expected. Probably also the importance of surgical preservation of intertrochanteric cancellous bone has been over-emphasized for osseointegration of cementless stem.
authors.affiliation: Orthopaedic Research Unit, Department of Orthopaedic Surgery and Traumatology, University of Turku, Kiinamyllykatu 10, Turku, Finland.
authors.forename: Niko
authors.initials: N
authors.lastname: Moritz
authors.forename: Jessica J
authors.initials: JJ
authors.lastname: Alm
authors.forename: Petteri
authors.initials: P
authors.lastname: Lankinen
authors.forename: Tatu J
authors.initials: TJ
authors.lastname: Mäkinen
authors.forename: Kimmo
authors.initials: K
authors.lastname: Mattila
authors.forename: Hannu T
authors.initials: HT
authors.lastname: Aro
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D001696:Biomechanical Phenomena; D001706:Biopsy; D015519:Bone Density; D001842:Bone and Bones / Q000502:physiology* / Q000503:physiopathology; D005260:Female; D005272:Femur Neck / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D016348:Osseointegration; D010024:Osteoporosis / Q000503:physiopathology; D011474:Prosthesis Design; D055114:X-Ray Microtomography / Q000379:methods