title: Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma.
abstract: Metastatic spermatocytic seminoma is an extremely rare disease. No chemotherapeutic regimen is established and the use of adjuvant radiation therapy after orchiectomy as frequently performed for classical seminoma is unclear. We report the third case of proven spermatocytic seminoma metastatic in the literature and provide a review of the literature. Administering BEP polychemotherapy as in classical seminoma was poorly effective in reducing the retroperitoneal mass in a patient with spermatocytic seminoma. A review of the literature showed that all the three described patients developing metastatic disease did not receive adjuvant radiation therapy after orchiectomy, which might be considered in high-risk cases.
authors.affiliation: Urologische Klinik und Poliklinik der Technischen Universität München, Ismaningerstraße 22, 81675 Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Horn
authors.forename: Stephan
authors.initials: S
authors.lastname: Schulz
authors.forename: Tobias
authors.initials: T
authors.lastname: Maurer
authors.forename: Jürgen E
authors.initials: JE
authors.lastname: Gschwend
authors.forename: Hubert R
authors.initials: HR
authors.lastname: Kübler
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D018239:Seminoma / Q000175:diagnosis / Q000188:drug therapy*; D013090:Spermatocytes / Q000473:pathology*; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin