title: Short communication: persistence of high blood levels of the chemokines CCL2, CCL19, and CCL20 during the course of HIV infection.
abstract: Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3α/CCL20), and MIP-3β/CCL19 remained elevated throughout the course of HIV infection suggesting that the relatively low levels of blood circulating DCs may be due to active recruitment of these cells to peripheral sites to fight disease progression.
authors.affiliation: Laboratoire d'Immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Fontaine
authors.forename: Johanne
authors.initials: J
authors.lastname: Poudrier
authors.forename: Michel
authors.initials: M
authors.lastname: Roger
mesh_terms: D001774:Blood Chemical Analysis; D054415:Chemokine CCL19 / Q000097:blood*; D018932:Chemokine CCL2 / Q000097:blood*; D054418:Chemokine CCL20 / Q000097:blood*; D003713:Dendritic Cells / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans
chemical_list: C515460:CCL19 protein, human; C111835:CCL2 protein, human; C108355:CCL20 protein, human; D054415:Chemokine CCL19; D018932:Chemokine CCL2; D054418:Chemokine CCL20