title: Evaluation of the relationship between a pharmaceutical compound's distribution coefficient, log D and adsorption loss to polypropylene in urine and CSF.
abstract: BACKGROUND
  The distribution coefficient, D, is a physicochemical property used to determine the partitioning of compounds between aqueous and hydrophobic media at a given pH.
  
  
  RESULTS
  A clear relationship was observed between the calculated pH-dependent distribution coefficient of six representative pharmaceutical probe compounds and their propensity to partition between a relatively hydrophobic polypropylene surface and the aqueous matrices, human urine or human cerebrospinal fluid (CSF). Compound log D cut-off values of 1.5 and 3.8 for urine and CSF, respectively, were determined using a threshold of less than 20% adsorption to the polypropylene surface.
  
  
  CONCLUSIONS
  The ability to forecast the adsorption of a given compound to a polypropylene container with urine and CSF offers an effective means for screening potential issues and identifying when additional testing and corrective measures may need to be applied.
authors.affiliation: Pfizer, Inc., Groton, CT 06340, USA. eugene.p.kadar@pfizer.com
authors.forename: Eugene P
authors.initials: EP
authors.lastname: Kadar
authors.forename: Yi
authors.initials: Y
authors.lastname: Su
authors.forename: Yizhong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Joseph
authors.initials: J
authors.lastname: Tweed
authors.forename: Chad E
authors.initials: CE
authors.lastname: Wujcik
mesh_terms: D000327:Adsorption; D002793:Cholic Acids / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000134:cerebrospinal fluid / Q000737:chemistry* / Q000652:urine; D011126:Polypropylenes / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D002793:Cholic Acids; D004364:Pharmaceutical Preparations; D011126:Polypropylenes; D012997:Solvents; C028213:3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate