title: Sugammadex: cyclodextrins, development of selective binding agents, pharmacology, clinical development, and future directions.
abstract: Neuromuscular blocking agents are widely used in perioperative medicine to aid in endotracheal intubation, facilitate surgery, and in critical care/emergency medicine settings. Muscle relaxants have profound clinical uses in current surgical and intensive care and emergency medical therapy. This article reviews cyclodextrins, development of selective binding agents, clinical development, and future directions of sugammadex.
authors.affiliation: UCLA JCCC Clinical Research Unit, 10945 Le Conte Avenue, 3360 PVUB, Los Angeles, CA 90095, USA.
authors.forename: Arezou Sadighi
authors.initials: AS
authors.lastname: Akha
authors.forename: Joseph
authors.initials: J
authors.lastname: Rosa
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Jahr
authors.forename: Alvin
authors.initials: A
authors.lastname: Li
authors.forename: Kianusch
authors.initials: K
authors.lastname: Kiai
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003505:Cyclodextrins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D017277:Drug Approval; D006801:Humans; D019148:Neuromuscular Blockade; D009466:Neuromuscular Blocking Agents / Q000378:metabolism*; D000077122:Sugammadex; D014481:United States; D014486:United States Food and Drug Administration; D047408:gamma-Cyclodextrins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D003505:Cyclodextrins; D009466:Neuromuscular Blocking Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex