title: Tolerability and efficacy of switching from oral selegiline to Zydis selegiline in patients with Parkinson's disease.
abstract: Selegiline is a monoamine-B specific inhibitor used to treat Parkinson's disease. A Zydis sublingual preparation has more efficient absorption and less first pass amphetamine metabolites. We conducted an open label oral to Zydis switch study to evaluate tolerability of rapid switch, and relative efficacy, in 48 subjects from 5 sites. Overall patients preferred the Zydis preparation. Per clinician global impressions, fluctuations improved and the "on" UPDRS part II scores improved. Total UPDRS and measures of fatigue and sleep were unchanged. Adverse events were mild. Patients generally preferred the Zydis selegiline preparation but the modest difference is of unclear clinical significance given the open label nature of the trial.
authors.affiliation: Dept. of Neurology, Baylor college of Medicine, 6550 Fannin, Ste 1801, Houston, TX 77030, USA. wondo@bcm.tmc.edu
authors.forename: William G
authors.initials: WG
authors.lastname: Ondo
authors.forename: Christine
authors.initials: C
authors.lastname: Hunter
authors.forename: Stuart H
authors.initials: SH
authors.lastname: Isaacson
authors.forename: Dee E
authors.initials: DE
authors.lastname: Silver
authors.forename: R Malcolm
authors.initials: RM
authors.lastname: Stewart
authors.forename: James W
authors.initials: JW
authors.lastname: Tetrud
authors.forename: Anthony
authors.initials: A
authors.lastname: Davidson
mesh_terms: D000284:Administration, Oral; D000286:Administration, Sublingual; D000368:Aged; D002626:Chemistry, Pharmaceutical; D057915:Drug Substitution / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism; D012642:Selegiline / Q000008:administration & dosage* / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D012642:Selegiline