title: Drug-eluting stents for coronary artery disease: a review.
abstract: Over the past decade the introduction of drug-eluting stents (DESs) has revolutionised the treatment of coronary artery disease. However, in recent years concern has arisen over the long-term safety and efficacy of DESs due to the occurrence of late adverse clinical events such as stent thrombosis. With this concern in mind, research and development is currently centred on increasing the long-term safety and efficacy of DESs. The aim of this paper is to provide a thorough review of currently approved and promising investigational DESs. With dozens of companies involved in the development of new and innovative anti-restenotic agents, polymeric coatings and stent platforms, it is intended that this review paper will provide a clear indication of how DESs are currently evolving and prove a valuable reference tool for future research in this area.
authors.affiliation: Department of Mechanical Engineering, Dublin Institute of Technology, Bolton St., Dublin 1, Ireland. david.martin@dit.ie
authors.forename: David M
authors.initials: DM
authors.lastname: Martin
authors.forename: Fergal J
authors.initials: FJ
authors.lastname: Boyle
mesh_terms: D017130:Angioplasty / Q000379:methods; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D004867:Equipment Design / Q000379:methods; D004869:Equipment Safety; D006801:Humans; D011474:Prosthesis Design; D018570:Risk Assessment; D015607:Stents; D013927:Thrombosis / Q000601:surgery; D016896:Treatment Outcome