title: The inverse correlation between Staphylococcus aureus and Streptococcus pneumoniae colonization in infants is not explained by differences in serum antibody levels in the Generation R Study.
abstract: Colonization rates of Streptococcus pneumoniae and Staphylococcus aureus are inversely correlated in infants. Several studies have searched for determinants of this negative association. We studied the association between antipneumococcal antibodies with Staphylococcus aureus colonization and the association between antistaphylococcal antibodies with pneumococcal colonization in healthy children in the pneumococcal vaccine era. In the first year of life, no association between maternal IgG levels and colonization was seen. In addition, no association between the IgG and IgA levels in the child versus colonization status was seen.
authors.affiliation: The Generation R Study Group, Erasmus Medical Center (Erasmus MC), Rotterdam, Netherlands.
authors.forename: Ankie
authors.initials: A
authors.lastname: Lebon
authors.forename: Nelianne J
authors.initials: NJ
authors.lastname: Verkaik
authors.forename: Corné P
authors.initials: CP
authors.lastname: de Vogel
authors.forename: Herbert
authors.initials: H
authors.lastname: Hooijkaas
authors.forename: Henri A
authors.initials: HA
authors.lastname: Verbrugh
authors.forename: Willem J B
authors.initials: WJ
authors.lastname: van Wamel
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Peter W M
authors.initials: PW
authors.lastname: Hermans
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Mitchell
authors.forename: Henriette A
authors.initials: HA
authors.lastname: Moll
authors.forename: Alex
authors.initials: A
authors.lastname: van Belkum
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D015331:Cohort Studies; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D009305:Nasopharynx / Q000382:microbiology; D009426:Netherlands / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D015995:Prevalence; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology / Q000302:isolation & purification*; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000907:Antibodies, Bacterial