title: Levels of pentraxin-3 in gingival crevicular fluid and plasma in periodontal health and disease.
abstract: BACKGROUND
  Pentraxins are classic mediators of inflammation and markers of acute-phase reactions. Pentraxin-3 (PTX3) is the first-identified long pentraxin and is believed to be a true independent indicator of disease activity. Although a classic pentraxin, C-reactive protein, and its association with various systemic diseases is well documented in the periodontal literature, there is no data on PTX3 to our knowledge.
  
  
  METHODS
  Forty participants (20 males and 20 females; age range: 23 to 50 years) were involved in the study. Participants were divided into three groups based on gingival index, probing depth, and clinical attachment level: the healthy group (group 1; n = 10), gingivitis group (group 2; n = 15), and periodontitis group (group 3; n = 15). Gingival crevicular fluid (GCF) and plasma samples collected from each subject were quantified for PTX3 levels using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  In tandem with the disease progression from healthy to gingivitis to periodontitis, the mean PTX3 concentrations increased in GCF and plasma. However, GCF values were higher than plasma values. It was found that PTX3 concentration was highest in group 3 and lowest in group 1. PTX3 concentrations also correlated positively with periodontal parameters.
  
  
  CONCLUSIONS
  GCF and plasma PTX3 concentrations correlated positively in all groups. However, within the limits of the present study, the differences in plasma PTX3 levels were not found to be statistically significant. Hence, GCF PTX3 values were considered a marker of inflammatory activity in periodontal disease. However, PTX3 deserves further consideration as a therapeutic target. Additional large-scale studies should be carried out to confirm positive correlations.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, India. periodontics_gdc@yahoo.co.in
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.forename: Rahul
authors.initials: R
authors.lastname: Kathariya
authors.forename: N M
authors.initials: NM
authors.lastname: Raghavendra
authors.forename: Anuj
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D016301:Alveolar Bone Loss / Q000097:blood / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005891:Gingivitis / Q000097:blood / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000378:metabolism; D010510:Periodontal Diseases / Q000097:blood / Q000145:classification / Q000378:metabolism*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000378:metabolism; D010519:Periodontium / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000032:analysis*; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins