title: Networking erythropoiesis.
abstract: A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene expression profiling, and comprehensive bioinformatic analyses, offer new insights into the intricacies of red cell molecular circuits.
authors.affiliation: Division of Hematology/Oncology, Children's Hospital Boston and the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Kerenyi
authors.forename: Stuart H
authors.initials: SH
authors.lastname: Orkin
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology; D047369:Chromatin Immunoprecipitation; D019295:Computational Biology; D004920:Erythropoiesis; D050982:GATA1 Transcription Factor / Q000502:physiology; D020869:Gene Expression Profiling; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D050982:GATA1 Transcription Factor; D051741:Kruppel-Like Transcription Factors; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors; C080774:erythroid Kruppel-like factor; C067143:TAL1 protein, human