title: [Effect of percutaneous intratumoral injection of lipiodol emulsion of chemotherapie agents on implanted VX2 tumor in rabbits].
abstract: OBJECTIVE
  To assess the therapeutic effect of percutaneous intratumoral injection with lipiodol emulsion of chemotherapie agents (CALE) on implanted VX2 tumor in rabbits.
  
  
  METHODS
  Twelve New Zealand rabbits with implanted VX2 tumor (24 models) were divided into lipiodol group, chemotherapeutic agent group and CALE group with intratumoral injections of the corresponding agents. The pathological changes of all the lesions were observed and the expression of proliferating cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) were evaluated 7 days after the operation.
  
  
  RESULTS
  Compared with the lipiodol group and chemotherapie agent group, intratumoral injection of CALE resulted in the highest tumor necrosis rate and greatest tumor necrosis (P<0.01). The labeling indices of PCNA and VEGF expressions in CALE group were markedly lower than those in the other two groups (P<0.01).
  
  
  CONCLUSIONS
  Percutaneous intratumoral injection of CALE is an effective ablation approach for treatment of malignant solid tumors.
authors.affiliation: Department of Radiology, Lanzhou General Hospital of Lanzhou Command, Lanzhou 730050, China. jinwensong2003@yahoo.com.cn
authors.forename: Jin-wen
authors.initials: JW
authors.lastname: Song
authors.forename: Yan-hao
authors.initials: YH
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Liu
authors.forename: Ji-jun
authors.initials: JJ
authors.lastname: Ning
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Xin-xia
authors.initials: XX
authors.lastname: Shi
mesh_terms: D000818:Animals; D004655:Emulsions; D015552:Injections, Intralesional; D007459:Iodized Oil / Q000008:administration & dosage* / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011817:Rabbits; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D004655:Emulsions; D018809:Proliferating Cell Nuclear Antigen; D042461:Vascular Endothelial Growth Factor A; D007459:Iodized Oil