title: [On the preparation and mechanical properties of PVA hydrogel bionic cartilage/bone composite artificial articular implants].
abstract: In view of the problems that conventional artificial cartilages have no bioactivity and are prone to peel off in repeated uses as a result of insufficient strength to bond with subchondral bone, we have designed and prepared a novel kind of PVA-BG composite hydrogel as bionic artificial articular cartilage/bone composite implants. The effects of processes and conditions of preparation on the mechanical properties of implant were explored. In addition, the relationships between compression strain rate, BG content, PVA hydrogels thickness and compressive tangent modulus were also explicated. We also analyzed the effects of cancellous bone aperture, BG and PVA content on the shear strength of bonding interface of artificial articular cartilage with cancellous bone. Meanwhile, the bonding interface of artificial articular cartilage and cancellous bone was characterized by scanning electron microscopy. It was revealed that the compressive modulus of composite implants was correspondingly increased with the adding of BG content and the augments of PVA hydrogel thickness. The compressive modulus and bonding interface were both related to the apertures of cancellous bone. The compressive modulus of composite implants was 1.6-2.23 MPa and the shear strength of bonding interface was 0.63-1.21 MPa. These results demonstrated that the connection between artificial articular cartilage and cancellous bone was adequately firm.
authors.affiliation: College of Materials Science and Engineering, Beijing University of Science and Technology, Beijing 100083, China.
authors.forename: Haoye
authors.initials: H
authors.lastname: Meng
authors.forename: Yudong
authors.initials: Y
authors.lastname: Zheng
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Huang
authors.forename: Bingqing
authors.initials: B
authors.lastname: Yue
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D040761:Biomimetic Materials / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D002358:Cartilage, Articular / Q000502:physiology / Q000601:surgery*; D019245:Compressive Strength; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011142:Polyvinyl Alcohol