title: Facile synthesis of Raman active phospholipid gold nanoparticles.
abstract: Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates Raman molecules adsorbed on 60 nm gold with a nonthiol phospholipid coating. Transmission electron microscopy and Raman and UV spectroscopy validated its reproducibility and stability. This novel lipid-based SERS probe provides a viable alternative to the PEGylation and silica coating strategies.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, Department of Medical Biophysics, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Natalie C M
authors.initials: NC
authors.lastname: Tam
authors.forename: Benjamin M T
authors.initials: BM
authors.lastname: Scott
authors.forename: Danut
authors.initials: D
authors.lastname: Voicu
authors.forename: Brian C
authors.initials: BC
authors.lastname: Wilson
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
mesh_terms: D000327:Adsorption; D003102:Colloids / Q000032:analysis / Q000138:chemical synthesis*; D016503:Drug Delivery Systems / Q000379:methods*; D005840:Gentian Violet / Q000737:chemistry / Q000378:metabolism; D006046:Gold / Q000032:analysis / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000032:analysis / Q000737:chemistry*; D010316:Particle Size; D010743:Phospholipids / Q000378:metabolism; D015203:Reproducibility of Results; D013059:Spectrum Analysis, Raman; D013499:Surface Properties
chemical_list: D003102:Colloids; D010743:Phospholipids; D006046:Gold; D005840:Gentian Violet