title: Model-free fMRI group analysis using FENICA.
abstract: Exploratory analysis of functional MRI data allows activation to be detected even if the time course differs from that which is expected. Independent Component Analysis (ICA) has emerged as a powerful approach, but current extensions to the analysis of group studies suffer from a number of drawbacks: they can be computationally demanding, results are dominated by technical and motion artefacts, and some methods require that time courses be the same for all subjects or that templates be defined to identify common components. We have developed a group ICA (gICA) method which is based on single-subject ICA decompositions and the assumption that the spatial distribution of signal changes in components which reflect activation is similar between subjects. This approach, which we have called Fully Exploratory Network Independent Component Analysis (FENICA), identifies group activation in two stages. ICA is performed on the single-subject level, then consistent components are identified via spatial correlation. Group activation maps are generated in a second-level GLM analysis. FENICA is applied to data from three studies employing a wide range of stimulus and presentation designs. These are an event-related motor task, a block-design cognition task and an event-related chemosensory experiment. In all cases, the group maps identified by FENICA as being the most consistent over subjects correspond to task activation. There is good agreement between FENICA results and regions identified in prior GLM-based studies. In the chemosensory task, additional regions are identified by FENICA and temporal concatenation ICA that we show is related to the stimulus, but exhibit a delayed response. FENICA is a fully exploratory method that allows activation to be identified without assumptions about temporal evolution, and isolates activation from other sources of signal fluctuation in fMRI. It has the advantage over other gICA methods that it is computationally undemanding, spotlights components relating to activation rather than artefacts, allows the use of familiar statistical thresholding through deployment of a higher level GLM analysis and can be applied to studies where the paradigm is different for all subjects.
authors.affiliation: MR Centre of Excellence, Medical University Vienna, Austria. veronika.schoepf@meduniwien.ac.at
authors.forename: V
authors.initials: V
authors.lastname: Schöpf
authors.forename: C
authors.initials: C
authors.lastname: Windischberger
authors.forename: S
authors.initials: S
authors.lastname: Robinson
authors.forename: C H
authors.initials: CH
authors.lastname: Kasess
authors.forename: F PhS
authors.initials: FP
authors.lastname: Fischmeister
authors.forename: R
authors.initials: R
authors.lastname: Lanzenberger
authors.forename: J
authors.initials: J
authors.lastname: Albrecht
authors.forename: A M
authors.initials: AM
authors.lastname: Kleemann
authors.forename: R
authors.initials: R
authors.lastname: Kopietz
authors.forename: M
authors.initials: M
authors.lastname: Wiesmann
authors.forename: E
authors.initials: E
authors.lastname: Moser
mesh_terms: D000465:Algorithms; D001921:Brain / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity