title: Targeted therapy in lymphoma.
abstract: Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma, such as aberrant signal transduction pathways, which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt/mammalian target of rapamycin (mTOR) pathways are examples of pathological mechanisms that are being targeted in drug development efforts. Bortezomib (a small molecule protease inhibitor) and the mTOR inhibitors temsirolimus, everolimus, and ridaforolimus are some of the targeted therapies currently being studied in the treatment of aggressive, relapsed/refractory lymphoma. This review will discuss the rationale for and summarize the reported findings of initial and ongoing investigations of mTOR inhibitors and other small molecule targeted therapies in the treatment of lymphoma.
authors.affiliation: Novartis Pharmaceuticals, Florham Park, NJ, USA.
authors.forename: Patrick B
authors.initials: PB
authors.lastname: Johnston
authors.forename: RuiRong
authors.initials: R
authors.lastname: Yuan
authors.forename: Franco
authors.initials: F
authors.lastname: Cavalli
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Witzig
mesh_terms: D001897:Boronic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D000069286:Bortezomib; D000068338:Everolimus; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D058990:Molecular Targeted Therapy / Q000379:methods*; D011719:Pyrazines / Q000008:administration & dosage / Q000627:therapeutic use; D015398:Signal Transduction; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D016019:Survival Analysis
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; C515074:ridaforolimus; C401859:temsirolimus; D000069286:Bortezomib; D000068338:Everolimus; D020123:Sirolimus