title: Viral respiratory tract infections among patients with acute undifferentiated fever in Vietnam.
abstract: To investigate the proportion of viral respiratory tract infections among acute undifferentiated fevers (AUFs) at primary health facilities in southern Vietnam during 2001-2005, patients with AUF not caused by malaria were enrolled at twelve primary health facilities and a clinic for malaria control program. Serum was collected on first presentation (t0) and after 3 weeks (t3) for serology. After exclusion of acute dengue infection, acute and convalescent serum samples from 606 patients were using enzyme-linked immunoassays to detect IgA, as well as IgM and IgG antibodies against common respiratory viruses. Paired sera showed the following infections: human parainfluenza virus (HPIV, 4.7%), influenza B virus (FLUBV, 2.2%), influenza A virus (FLUAV, 1.9%) and human respiratory syncytial virus (HRSV, 0.6%). There was no association between type of infection and age, sex or seasonality; some inter-annual differences were observed for influenza. Antibody prevalence, indicative of previous infections, was relatively low: HPV, 56.8%, FLUBV, 12.1%; FLUAV, 5.9% and HRSV, 6.8%.
authors.affiliation: Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Hoang Lan
authors.initials: HL
authors.lastname: Phuong
authors.forename: Tran T T
authors.initials: TT
authors.lastname: Nga
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: van Doornum
authors.forename: Jan
authors.initials: J
authors.lastname: Groen
authors.forename: Tran Q
authors.initials: TQ
authors.lastname: Binh
authors.forename: Phan T
authors.initials: PT
authors.lastname: Giao
authors.forename: Le Q
authors.initials: le Q
authors.lastname: Hung
authors.forename: Nguyen V
authors.initials: NV
authors.lastname: Nams
authors.forename: P A
authors.initials: PA
authors.lastname: Kager
authors.forename: Peter J
authors.initials: PJ
authors.lastname: de Vries
mesh_terms: D000208:Acute Disease; D016009:Chi-Square Distribution; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005334:Fever / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D016036:Seroepidemiologic Studies; D014744:Vietnam / Q000453:epidemiology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M