title: An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.
abstract: Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.
authors.affiliation: Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK.
authors.forename: Abdelilah
authors.initials: A
authors.lastname: Arredouani
authors.forename: A Mark
authors.initials: AM
authors.lastname: Evans
authors.forename: Jianjie
authors.initials: J
authors.lastname: Ma
authors.forename: John
authors.initials: J
authors.lastname: Parrington
authors.forename: Michael X
authors.initials: MX
authors.lastname: Zhu
authors.forename: Antony
authors.initials: A
authors.lastname: Galione
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D009249:NADP / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D009249:NADP; C024376:NAADP; D002118:Calcium