title: Kisspeptin and fertility.
abstract: The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the hypothalamic-pituitary-gonadal axis, thus in turn influencing fertility and reproduction. This review examines the physiological role of kisspeptin and the kisspeptin receptor in the control of gonadotrophin and gonadal steroid hormone secretion and the implications of these findings with respect to fertility. In addition, the potential therapeutic use of kisspeptin in the treatment of reproductive disorders will be examined.
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6th Floor Commonwealth Building, Du Cane Road, London W12 0NN, UK.
authors.forename: Saira
authors.initials: S
authors.lastname: Hameed
authors.forename: Channa N
authors.initials: CN
authors.lastname: Jayasena
authors.forename: Waljit S
authors.initials: WS
authors.lastname: Dhillo
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism; D025461:Feedback, Physiological; D005298:Fertility / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism*; D006066:Gonads / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D007246:Infertility / Q000188:drug therapy; D059648:Kisspeptins; D009474:Neurons / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D009752:Nutritional Status / Q000502:physiology; D010902:Pituitary Gland / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D000074502:Receptors, Kisspeptin-1; D012098:Reproduction / Q000502:physiology; D012621:Seasons; D015398:Signal Transduction / Q000502:physiology; D013256:Steroids / Q000378:metabolism; D014018:Tissue Distribution; D025521:Tumor Suppressor Proteins / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D006062:Gonadotropins; C106628:KISS1 protein, human; C118688:KISS1R protein, human; D059648:Kisspeptins; D009479:Neuropeptides; D043562:Receptors, G-Protein-Coupled; D000074502:Receptors, Kisspeptin-1; D013256:Steroids; D025521:Tumor Suppressor Proteins; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone