title: Chiral amine thiourea-promoted enantioselective Michael addition reactions of 3-substituted benzofuran-2(3H)-ones to maleimides.
abstract: A highly diastereo- and enantioselective Michael addition reaction with respect to prochiral 3-substituted benzofuran-2(3H)-ones and maleimides by a chiral bifunctional thiourea-tertiary amine catalyst was investigated. The corresponding adducts, containing a quaternary center at the C3-position of the benzofuran-2(3H)-one as well as a vicinal tertiary center, were generally obtained in high yields (up to 99%) with very good diastereo- (up to >20:1 dr) and enantioselectivities (up to 97% ee).
authors.affiliation: Department of Chemistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China. xin_li@nankai.edu.cn
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Shenshen
authors.initials: S
authors.lastname: Hu
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Xi
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Cheng