title: Black soy peptide supplementation improves glucose control in subjects with prediabetes and newly diagnosed type 2 diabetes mellitus.
abstract: The present study aimed to determine the effect of black soy peptide supplementation on glucose control in subjects with prediabetes (impaired fasting glucose or impaired glucose tolerance) and newly diagnosed type 2 diabetes mellitus (DM). In this double-blind, placebo-controlled study, subjects with prediabetes and type 2 DM were randomly assigned to the placebo control group or the black soy peptide intervention group. We determined fasting serum concentrations of glucose, hemoglobin A1c, insulin, and free fatty acids, performed a 2-hour postload glucose (2-hour PG) test, and compared serum lipid profiles before and after the 12-week supplementation. In particular, subjects with fasting glucose ≥ 110 mg/dL who consumed black soy peptides tended to have lower fasting glucose levels (two-tailed test, P = .098; one-tailed test, P = .049) and had a significant reduction in 2-hour PG level (two-tailed P = .012, one-tailed P = .006), compared with baseline levels. The changes in 2-hour PG levels were also statistically significant in the intervention group (-41.25 ± 13.67 mg/dL) compared with the placebo group (12.42 ± 9.80 mg/dL; two-tailed P = .015, one-tailed P = .008). In contrast, hemoglobin A1c levels were not significantly improved by the dietary intervention. In conclusion, black soy peptide supplementation may be beneficial for controlling fasting blood glucose levels and 2-hour PG levels.
authors.affiliation: Interdisciplinary Course of Science for Aging, Graduate School, Yonsei University, Seoul, Republic of Korea.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Kwak
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Chang-Won
authors.initials: CW
authors.lastname: Ahn
authors.forename: Soo-Hyun
authors.initials: SH
authors.lastname: Park
authors.forename: Sun-Taek
authors.initials: ST
authors.lastname: Shim
authors.forename: Yong Duk
authors.initials: YD
authors.lastname: Song
authors.forename: Eun Narae
authors.initials: EN
authors.lastname: Han
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Jey-Sook
authors.initials: JS
authors.lastname: Chae
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy*; D004032:Diet; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D018149:Glucose Intolerance; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use*; D011236:Prediabetic State / Q000097:blood / Q000178:diet therapy*; D030262:Soybean Proteins / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D010455:Peptides; D030262:Soybean Proteins; C517652:hemoglobin A1c protein, human