title: Glucagonlike peptide-1 receptor: an example of translational research in insulinomas: a review.
abstract: Glucagonlike peptide-1 receptors (GLP-1R) play an increasingly important role in endocrine gastrointestinal tumor management. In particular, virtually all benign insulinomas express GLP-1R in high density. Exendin-4 is a GLP-1 analog that has a longer half-life than GLP-1. Targeting GLP-1R by (111)In-DOTA-exendin-4 or (111)In-DPTA-exendin-4 offers a new approach that permits the successful localization of small benign insulinomas. It is likely that this new noninvasive technique has the potential to replace the invasive localization by selective arterial stimulation and venous sampling.
authors.affiliation: Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital of Berne Inselspital, Freiburgstrasse 15, CH 3010 Berne, Switzerland.
authors.forename: Emanuel
authors.initials: E
authors.lastname: Christ
authors.forename: Damian
authors.initials: D
authors.lastname: Wild
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Reubi
mesh_terms: D000818:Animals; D003940:Diagnostic Techniques, Endocrine; D004195:Disease Models, Animal; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D025202:Molecular Diagnostic Techniques; D058990:Molecular Targeted Therapy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D018027:Receptors, Glucagon / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D057170:Translational Research, Biomedical / Q000379:methods
chemical_list: C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon