title: Broadening our horizons: gene expression profiling to help better understand the neurobiology of suicide and depression.
abstract: The complexity of the neurobiological alterations underlying major depression and suicide is significant. Gene expression studies using high-throughput genomic technologies have provided important insight into novel genes and pathways displaying alterations associated with major depression and suicide, thereby providing a global view of the pathological changes taking place, as well as indicating potential new targets for therapeutic interventions. This review discusses the methodologies which have been used to profile gene expression patterns in depression and suicide, as well as examines several of the metabolic pathways which have been frequently implicated by studies using this approach. Future directions to be taken towards increasing our understanding of the origin and downstream effects of altered gene expression are also discussed.
authors.affiliation: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 LaSalle Boulevard, Verdun, Quebec, Canada, H4H 1R3. laura.fiori@mail.mcgill.ca
authors.forename: Laura M
authors.initials: LM
authors.lastname: Fiori
authors.forename: Gustavo
authors.initials: G
authors.lastname: Turecki
mesh_terms: D003866:Depressive Disorder / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D017397:Prefrontal Cortex / Q000378:metabolism*; D013405:Suicide