title: Effects of alcohol consumption on iron metabolism.
abstract: OBJECTIVE
  Patients with alcohol abuse frequently suffer from malnutrition which may result in insufficient iron distribution and iron overload or deficiency. Iron metabolism can be described by a combination of biochemical soluble transferrin receptor, ferritin, C-reactive protein (CRP), and hematological parameters. Here, vitamin B12 and folic acid state were assessed. Results on iron metabolism in patients with alcohol dependence in comparison with social drinkers are presented.
  
  
  METHODS
  Samples from 101 patients with dependent alcohol consumption were included. The control group comprised 115 social drinkers. Inclusion criteria for patients with chronic regular drinking/social drinkers were positive/negative score of the Alcohol Use Disorders Identification Test (AUDIT), and positive/negative score for alcohol abuse/dependence (DSM-IV criteria).
  
  
  RESULTS
  Absolute values for ferritin and sTfR are increased in patients with alcohol dependence with current consumption (ALC) compared with social drinkers. No major differences are observed in the ratio of sTfR/log ferritin in comparison with social drinkers. Hemoglobin concentrations correlated between the two groups. Mean corpuscular volume (MCV) was significantly increased in the ALC collective compared to social drinkers. Eighty patients of the alcohol-dependent group had sufficient iron repletion, 11 had iron overload, 6 are suspicious for functional iron deficiency, and 4 are suspicious for reduced iron supply. No vitamin B12/folate deficiencies are observed in alcohol-dependent patients.
  
  
  CONCLUSIONS
  No major abnormalities of iron metabolism are seen in patients with chronic alcohol ingestion besides the well-known macrocytic anemia. Iron overload is relatively frequent and observed in 9% of cases. No differences in vitamin B12 and folate levels were found between individuals with alcohol dependence and social drinkers.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany. martin.lieb@med.uni-muenchen.de
authors.forename: M
authors.initials: M
authors.lastname: Lieb
authors.forename: U
authors.initials: U
authors.lastname: Palm
authors.forename: B
authors.initials: B
authors.lastname: Hock
authors.forename: M
authors.initials: M
authors.lastname: Schwarz
authors.forename: I
authors.initials: I
authors.lastname: Domke
authors.forename: M
authors.initials: M
authors.lastname: Soyka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D003430:Cross-Sectional Studies; D004909:Erythrocyte Indices; D005260:Female; D005293:Ferritins; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000378:metabolism; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D014168:Transferrin; D005293:Ferritins; D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12