title: Synthesis and characterization of thermo-sensitive radio-opaque poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate).
abstract: Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by (1)H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.
authors.affiliation: a Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, USA.
authors.forename: Bae Hoon
authors.initials: BH
authors.lastname: Lee
authors.forename: Christine
authors.initials: C
authors.lastname: Leon
authors.forename: Ryan
authors.initials: R
authors.lastname: McLemore
authors.forename: Jorge Valdez
authors.initials: JV
authors.lastname: Macias
authors.forename: Brent L
authors.initials: BL
authors.lastname: Vernon
mesh_terms: D016475:3T3 Cells; D000178:Acrylamides / Q000737:chemistry; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002470:Cell Survival; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry*; D007463:Iodobenzoates / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D008970:Molecular Weight; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D044366:Transition Temperature; D014965:X-Rays
chemical_list: D000178:Acrylamides; D003287:Contrast Media; D007463:Iodobenzoates; D011108:Polymers; C067295:N-isopropylacrylamide