title: The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH--towards novel bacterial antiadhesives.
abstract: Fullerene hexakis-adducts bearing 12 peripheral mannose moieties have been prepared by grafting sugar derivatives onto the fullerene core and assayed as inhibitors of FimH, a bacterial adhesin, using isothermal titration calorimetry, surface plasmon resonance and hemagglutination assays.
authors.affiliation: University of Namur (FUNDP), Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, B-5000 Namur, Belgium.
authors.forename: Maxime
authors.initials: M
authors.lastname: Durka
authors.forename: Kevin
authors.initials: K
authors.lastname: Buffet
authors.forename: Julien
authors.initials: J
authors.lastname: Iehl
authors.forename: Michel
authors.initials: M
authors.lastname: Holler
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Nierengarten
authors.forename: Joemar
authors.initials: J
authors.lastname: Taganna
authors.forename: Julie
authors.initials: J
authors.lastname: Bouckaert
authors.forename: Stéphane P
authors.initials: SP
authors.lastname: Vincent
mesh_terms: D018830:Adhesins, Escherichia coli / Q000737:chemistry*; D002151:Calorimetry; D004926:Escherichia coli / Q000378:metabolism*; D036781:Fimbriae Proteins / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D006385:Hemagglutination Inhibition Tests; D008358:Mannose / Q000737:chemistry; D020349:Surface Plasmon Resonance
chemical_list: D018830:Adhesins, Escherichia coli; D037741:Fullerenes; C058769:fimH protein, E coli; D036781:Fimbriae Proteins; D008358:Mannose