title: The Association of Ménétrier Disease with Ulcerative Colitis: A Case Report with Implications on the Pathogenesis of Ménétrier Disease.
abstract: Ménétrier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed.
authors.affiliation: Department of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Ariz., USA.
authors.forename: Vien X
authors.initials: VX
authors.lastname: Nguyen
authors.forename: Cuong C
authors.initials: CC
authors.lastname: Nguyen
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Leighton
authors.forename: Shabana F
authors.initials: SF
authors.lastname: Pasha
authors.forename: Alvin C
authors.initials: AC
authors.lastname: Silva
authors.forename: Jacques P
authors.initials: JP
authors.lastname: Heppell
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Petris