title: Precursor B cell lymphoblastic lymphoma presenting as a solitary bone tumor: a case report and review of the literature.
abstract: Precursor B cell lymphoblastic lymphoma (B-LBL) is quite uncommon and it usually manifests as an extranodal disease. Although B-LBL may present with bone involvement, it is a very rare manifestation of B-LBL as a primary solitary bone tumor. Here, we report a case of precursor B-LBL presenting with solitary bone tumor and a review of a total of seven adult patients reported previously in the literature. We described demographic and clinical characteristics of these patients with unique presentation and discussed treatment options. Unlike previous reports except one case, our patient underwent allogeneic stem cell transplantation (allo-SCT) due to refractory disease. She is alive without evidence of disease by the post-transplant 12th month. B-LBL has an aggressive clinical course in adult patients and allo-SCT may be the best treatment option.
authors.affiliation: Division of Hematology, Marmara University School of Medicine, Istanbul, Turkey. isikkaygusuz@yahoo.com
authors.forename: Isik
authors.initials: I
authors.lastname: Kaygusuz
authors.forename: Tayfur
authors.initials: T
authors.lastname: Toptas
authors.forename: Aslihan
authors.initials: A
authors.lastname: Guven
authors.forename: Tulin
authors.initials: T
authors.lastname: Firatli-Tuglular
authors.forename: Tulay
authors.initials: T
authors.lastname: Tecimer
authors.forename: Mahmut
authors.initials: M
authors.lastname: Bayik
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D011241:Prednisone / Q000008:administration & dosage; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone