title: [Levels of cytokines in peripheral blood of premature infants with chronic lung disease].
abstract: OBJECTIVE
  This study examined the levels of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor alpha (TNF-α) in peripheral blood of premature infants with chronic lung disease (CLD) in order to investigate the possible role of immunologic factors in CLD.
  
  
  METHODS
  Twenty-six premature infants who had been admitted to the neonatal intensive care unit for 28 days were classified into CLD (n=14) and non-CLD (control, n=12) groups. IL-1β, IL-6, IL-8 and TNF-α concentrations in peripheral blood were measured by multiplex technique (Bio-plex).
  
  
  RESULTS
  There were no significant differences in peripheral blood levels of IL-1β, IL-6, IL-8 and TNF-α between the two groups.
  
  
  CONCLUSIONS
  There are no significant changes in peripheral blood levels of IL-1β, IL-6, IL-8 and TNF-α in premature infants with CLD on the non-acute phase. Immunologic factors might not play a key role in CLD on the phase.
authors.affiliation: Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tang
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Huang
mesh_terms: D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000276:immunology*; D008171:Lung Diseases / Q000276:immunology*; D008297:Male
chemical_list: D016207:Cytokines