title: Issues of prematurity and HIV infection.
abstract: Prematurity and HIV present a complex challenge, with biologic underpinnings that are often confounded by a myriad of other factors that coexist in this high-risk population. Furthermore, many of the current management options designed to reduce mother-to-infant transmission, including antiretroviral therapy and cesarean birth, may each have an independent effect on prematurity. These issues notwithstanding, knowledge gained from randomized controlled trials and epidemiologic studies has made a significant impact on the approach to this challenging public health problem worldwide. This article discusses the significance, contribution, and management of perinatal transmission of HIV in prematurity.
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA, USA. juliemir@gmail.com
authors.forename: Julie
authors.initials: J
authors.lastname: Mirpuri
authors.forename: Lucky
authors.initials: L
authors.lastname: Jain
mesh_terms: D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018450:Disease Progression; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000706:statistics & numerical data; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D011159:Population Surveillance; D014611:Vaccination
chemical_list: D044966:Anti-Retroviral Agents