title: Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin.
abstract: A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.
authors.affiliation: School of Chemistry and the Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, Scotland KY16 9ST, UK.
authors.forename: Christopher P A T
authors.initials: CP
authors.lastname: Lawson
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Westwood
mesh_terms: D000578:Amidines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000578:Amidines; D006576:Heterocyclic Compounds, 4 or More Rings; C472645:blebbistatin; D003300:Copper