title: Automation of labelling of Lipiodol with high-activity generator-produced 188Re.
abstract: This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52±2.3% and extraction yield was 98.56±1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68±9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol ((188)Re-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07±0.9%).
authors.affiliation: Service de Médecine Nucléaire, Centre Régional de Lutte Contre le Cancer Eugène Marquis, CS 44229, 35042 Rennes, France. n.lepareur@rennes.fnclcc.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lepareur
authors.forename: Valérie
authors.initials: V
authors.lastname: Ardisson
authors.forename: Nicolas
authors.initials: N
authors.lastname: Noiret
authors.forename: Eveline
authors.initials: E
authors.lastname: Boucher
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Raoul
authors.forename: Bruno
authors.initials: B
authors.lastname: Clément
authors.forename: Etienne
authors.initials: E
authors.lastname: Garin
mesh_terms: D057205:Automation, Laboratory; D004998:Ethiodized Oil / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D011868:Radioisotopes; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012211:Rhenium
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium; D004998:Ethiodized Oil