title: Limitations in daily activities are the major determinant of reduced health-related quality of life in patients with hand osteoarthritis.
abstract: OBJECTIVE
  To determine the impact of limitations in daily activities and pain on quality of life (QoL) in patients with osteoarthritis (OA) visiting a rheumatologist.
  
  
  METHODS
  Patients diagnosed by the rheumatologist with primary hand, knee or hip OA were consecutively included from August 2005 to April 2009. QoL was assessed by Short Form-36, with the physical component summary score (PCS), calculated using data from a norm-based population. Self-reported pain and function in patients with hand OA was assessed by the Australian/Canadian OA hand index (AUSCAN) pain (range 0-20) and AUSCAN function (range 0-36). Linear regression analyses were performed to investigate associations between PCS and demographic characteristics, and between PCS and pain and function in patients with OA.
  
  
  RESULTS
  Hand OA was diagnosed in 95% of 460 included patients (89% women, mean age 61 years). PCS was lowered in patients with OA. Patients with hand OA reported a considerable amount of pain (mean 9.5 (SD 4.3)) and disability (mean 16.5 (SD 8.6)). AUSCAN function was associated with PCS (adjusted β=-0.3, 95% CI -0.4 to -0.2), but AUSCAN pain was not.
  
  
  CONCLUSIONS
  Hand OA was the most common OA subtype in secondary care. Health-related QoL is decreased in patients with OA and is associated with limitations in daily activities.
authors.affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. w.y.kwok@lumc.nl
authors.forename: W Y
authors.initials: WY
authors.lastname: Kwok
authors.forename: T P M
authors.initials: TP
authors.lastname: Vliet Vlieland
authors.forename: F R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: T W J
authors.initials: TW
authors.lastname: Huizinga
authors.forename: M
authors.initials: M
authors.lastname: Kloppenburg
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000209:etiology; D016022:Case-Control Studies; D004185:Disability Evaluation; D005260:Female; D050823:Hand Joints / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000534:rehabilitation*; D010147:Pain Measurement / Q000379:methods; D010641:Phenotype; D011594:Psychometrics; D011788:Quality of Life; D011859:Radiography