title: [Expressions and clinical significances of TSLC1 and 4.1B in non-small cell lung cancer].
abstract: BACKGROUND
  Tumor suppressor in lung cancer-1 (TSLC1) belongs to immunoglobulin superfamily of cell adhesion molecule and differentially expressed in adenocarcinoma of the lung (4.1B)belongs to NF2/ERM/4.1 protein superfamily. They may suppress carcinogenesis via construction of the adjacent cell adhesion stability. The aim of this study is to detect the expressions of TSLC1 and 4.1B in non-small cell lung cancer and the clinical pathological significances.
  
  
  METHODS
  The expressions of TSLC1 and 4.1B were detected by RT-PCR in 52 cases of non-small cell lung cancer and corresponding adjacent cancer lung tissues
  
  
  RESULTS
  The expressions of TSLC1 and 4.1B in cancer tissues were significantly lower than that in adjacent cancer lung tissues (0.349 ± 0.008 vs 0.555 ± 0.010; 0.209 ± 0.040 vs 0.721 ± 0.071) (P < 0.01). The expressions of TSLC1 and 4.1B showed a significant correlation with cancer differentiation and TNM staging (P < 0.05), but not with gender, age and pathological type (P > 0.05). The expressions of TSLC1 and 4.1B were positively correlated (r=0.471, P < 0.001).
  
  
  CONCLUSIONS
  Down-regulated expressions of TSLC1 and 4.1B in non-small cell lung cancer, both may participate in a cascade of non-small cell lung cancer occurrence and development. TSLC1 and 4.1B are promising targets for non-small cell lung cancer diagnosis and treatment.
authors.affiliation: Department of Thoracic Surgery, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Wang
authors.forename: Kunpeng
authors.initials: K
authors.lastname: Yang
authors.forename: Xuguang
authors.initials: X
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Dexun
authors.initials: D
authors.lastname: Hao
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics* / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008840:Microfilament Proteins; D008875:Middle Aged; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C403514:CADM1 protein, human; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules; C116887:EPB41L3 protein, human; D007136:Immunoglobulins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D025521:Tumor Suppressor Proteins