title: Methicillin-resistant Staphylococcus-aureus-associated glomerulonephritis on the decline: decreased incidence since the 1990s.
abstract: We believe that bacterial-infection-associated glomerulonephritis (GN), so-called methicillin-resistant Staphylococcus aureus (MRSA)-GN, was exterminated in Japan. The control of bacterial infection is the most important part of infection-associated GN. In 1990s Japan, hospital-associated MRSA (HA-MRSA) caused MRSA-GN outbreaks. On the other hand, MRSA-GN incidence has been quite limited since 2000. This epidemiological transition suggests that antibacterial therapies and health programs for HA-MRSA infection in Japan were effective against MRSA-GN. Moreover, it appears that staphylococcal superantigens act in the pathogenesis of GN. The change of superantigen production might have influenced to the disappearance of MRSA-GN. If HA-MRSA-producing superantigen outbreaks occur in developing countries, our experience in Japan can provide guiding principles for preventing and eradicating GN.
authors.forename: Joichi
authors.initials: J
authors.lastname: Usui
authors.forename: Masaki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Itaru
authors.initials: I
authors.lastname: Ebihara
authors.forename: Akio
authors.initials: A
authors.lastname: Koyama
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
mesh_terms: D005921:Glomerulonephritis / Q000453:epidemiology* / Q000209:etiology* / Q000382:microbiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000472:pathogenicity*; D013203:Staphylococcal Infections / Q000150:complications* / Q000453:epidemiology*