title: Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.
abstract: Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.
authors.affiliation: Lpath, Inc., 6335 Ferris Square, Suite A, San Diego, CA 92121, USA. rsabbadini@lpath.com
authors.forename: Roger A
authors.initials: RA
authors.lastname: Sabbadini
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D055808:Drug Discovery; D006801:Humans; D008246:Lysophospholipids / Q000276:immunology* / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D049349:Receptors, Lysosphingolipid / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000276:immunology / Q000378:metabolism; D057135:Wet Macular Degeneration / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine