title: Role of uterine artery Doppler velocimetry indices and plasma adrenomedullin level in women with unexplained recurrent pregnancy loss.
abstract: OBJECTIVE
  To evaluate uterine artery Doppler flow resistance and plasma adrenomedullin levels in women with unexplained recurrent pregnancy loss (RPL) compared to controls.
  
  
  METHODS
  Eighty-three women, who attend the department of Obstetrics and Gynecology, Benha University, Egypt, participated in this study (RPL group: n=40, and control group: n=43). Uterine artery Doppler and plasma adrenomedullin (AM) (pg/mL) levels were measured for all women in the mid-luteal phase of a non-pregnant cycle.
  
  
  RESULTS
  Both uterine artery pulsatility index (PI) and AM levels were significantly higher in RPL group compared to controls (2.71 ± 0.259 vs 2.06 ± 0.194 for PI and 287.5 ± 80.4 pg/mL vs 156.1 ± 39.8 pg/mL for AM, P<0.01). Uterine artery PI had a significant positive correlation with plasma AM levels both in the RPL group (r=0.645, P<0.001) and in the control group (r=0.384, P=0.011). Number of previous miscarriages in RPL group was significantly correlated with both uterine artery PI (r=0.838, P=0.015) and plasma AM levels (r=0.509, P=0.001).
  
  
  CONCLUSIONS
  Uterine artery PI may be useful in identifying women with unexplained RPL who have impaired uterine circulation. Plasma AM may serve as a biochemical marker for RPL caused by impaired uterine perfusion.
authors.affiliation: Department of Obstetrics and Gynecology, Benha Faculty of Medicine, Benha University, Benha, Egypt. ashraf_elmashad8@yahoo.com
authors.forename: Ashraf I
authors.initials: AI
authors.lastname: El-mashad
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Mohamed
authors.forename: Mohamed A Elahadi
authors.initials: MA
authors.lastname: Farag
authors.forename: Mohsen K
authors.initials: MK
authors.lastname: Ahmad
authors.forename: Yaser
authors.initials: Y
authors.lastname: Ismail
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000503:physiopathology*; D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D011247:Pregnancy; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D014463:Ultrasonography; D055988:Uterine Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014599:Uterus / Q000098:blood supply
chemical_list: C507862:ADM protein, human; D015415:Biomarkers; D053607:Adrenomedullin