title: β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity.
abstract: The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC(50) values in the range of 11.3 to 19.3 μM.
authors.affiliation: Graduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung 401, Taiwan, Republic of China.
authors.forename: Yuh-Fung
authors.initials: YF
authors.lastname: Chen
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Hsiu-Hui
authors.initials: HH
authors.lastname: Chan
authors.forename: I-Je
authors.initials: IJ
authors.lastname: Kuo
authors.forename: Fu-Wen
authors.initials: FW
authors.lastname: Lin
authors.forename: Chung-Ren
authors.initials: CR
authors.lastname: Su
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.forename: Ding-Tzai
authors.initials: DT
authors.lastname: Li
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D018517:Plant Roots; D029752:Stellaria / Q000737:chemistry*; D013237:Stereoisomerism; D013624:Taiwan
chemical_list: D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002243:Carbolines; D006027:Glycosides; D008070:Lipopolysaccharides; D009569:Nitric Oxide