title: Rh-catalyzed [7 + 1] cycloaddition of buta-1,3-dienylcyclopropanes and CO for the synthesis of cyclooctadienones.
abstract: Discovering new carbon building blocks is very significant to advance transition-metal-catalyzed cycloadditions for the synthesis of various-sized ring compounds. A new seven-carbon building block from buta-1,3-dienylcyclopropanes (BDCPs) has been developed, showing that, under the catalysis of [Rh(CO)(2)Cl](2), BDCPs react with CO to give [7 + 1] cycloaddition products, cyclooctadienones. The present [7 + 1] reaction provides an efficient entry to the synthetically challenging eight-membered carbocyclic skeleton, which is present in many natural products of medicinal and biological significance.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Zhong-Ke
authors.initials: ZK
authors.lastname: Yao
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Yu
mesh_terms: D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D034242:Cyclooctanes / Q000138:chemical synthesis*; D003521:Cyclopropanes / Q000737:chemistry*; D007536:Isomerism; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: D034242:Cyclooctanes; D003521:Cyclopropanes; D002248:Carbon Monoxide; D012238:Rhodium; C474479:cyclooctane