title: Novel platinum-N-heterocyclic carbene complex is more cardiotoxic than cis-platin in rats.
abstract: Cis-platin and other platinum complexes are important chemotherapeutic agents useful in the treatment of several cancers. However, therapeutic usage of cis-platin and other platinum complex are limited by their undesirable side effects including cardiotoxicity. In this context, we aimed to compare the damage caused in heart by cis-platin and novel platinum-N-heterocyclic carbene (Pt-NHC) complex. For this purpose, 35 Sprague-Dawley rats were divided randomly into five equal groups (n = 7 for each group). Cis-platin and novel Pt-NHC complex were intraperitoneally administered at a single dose of 5 mg/kg and 10 mg/kg and then sacrificed 10 days after this treatment. The heart tissues were taken from all rats for determination of oxidative and myocardial damage. Cis-platin and novel Pt-NHC complex caused oxidative and histological damage in the heart tissue in a dose-dependent manner (p < 0.05). On the other hand, at the same dose levels, cis-platin caused lower oxidative and histological damage in heart tissue compared to novel Pt-NHC complex. These results suggest that novel Pt-NHC complex is more cardiotoxic than cis-platin.
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İnönü University, Malatya, Turkey. ociftci@inonu.edu.tr
authors.forename: Osman
authors.initials: O
authors.lastname: Ciftci
authors.forename: Ilknur
authors.initials: I
authors.lastname: Ozdemir
authors.forename: Nigar
authors.initials: N
authors.lastname: Vardi
authors.forename: Nevin
authors.initials: N
authors.lastname: Gurbuz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D009944:Organoplatinum Compounds; C030011:carbene; D008697:Methane; D002945:Cisplatin