title: Synthesis of novel sugar-lactam conjugates using the Aubé reaction.
abstract: An efficient and convenient method for the synthesis of sugar-lactam conjugates is reported starting from readily available sugar azides using the Aubé reaction. Cyclic azido alcohols are used in the Aubé reaction for the first time in a carbohydrate setting. The resulting glycoconjugates could be further used to increase the chemical diversity on the sugar backbone, and may find potential applications as glycomimetics, peptidomimetics, in glycotargeting and in CNS drug delivery.
authors.affiliation: Discovery Chemistry, Advinus Therapeutics Ltd., Quantum Towers, Plot No. 9, Rajiv Gandhi Infotech Park, Phase-I, Hinjewadi, Pune, 411057, India.
authors.forename: Suresh E
authors.initials: SE
authors.lastname: Kurhade
authors.forename: Tanaji
authors.initials: T
authors.lastname: Mengawade
authors.forename: Debnath
authors.initials: D
authors.lastname: Bhuniya
authors.forename: Venkata P
authors.initials: VP
authors.lastname: Palle
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D002241:Carbohydrates; D007769:Lactams