title: Blood pressure control in resistant hypertension: new therapeutic options.
abstract: Resistant hypertension, namely the hypertensive state characterized by the inability of multiple antihypertensive drug interventions to lower blood pressure to goal levels, represents a condition frequently detected in clinical practice. Its main features are represented by its heterogeneous etiology as well as its very high cardiovascular risk. This latter peculiarity has implemented the research for new approaches to the treatment of the disease. This article will focus on two of them, namely carotid baroreceptor electric stimulation and the renal denervation procedure. Clinical studies and large-scale clinical trials are presently ongoing with the aim of defining the long-term efficacy and safety profile of the two interventions.
authors.affiliation: Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano-Bicocca, Ospedale San Gerardo, Via Pergolesi 33, 20052 Monza, Milan, Italy. guido.grassi@unimib.it
authors.forename: Guido
authors.initials: G
authors.lastname: Grassi
authors.forename: Fosca
authors.initials: F
authors.lastname: Quarti-Trevano
authors.forename: Gianmaria
authors.initials: G
authors.lastname: Brambilla
authors.forename: Gino
authors.initials: G
authors.lastname: Seravalle
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D002346:Carotid Sinus / Q000294:innervation; D017115:Catheter Ablation; D004599:Electric Stimulation Therapy; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D011311:Pressoreceptors / Q000503:physiopathology; D012077:Renal Artery / Q000294:innervation; D013562:Sympathectomy; D017211:Treatment Failure