title: Synthesis and antifungal evaluation of 6-hydroxy-1H-carbazole-1,4(9H)-diones.
abstract: 6-Hydroxy-1H-carbazole-1,4(9H)-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 6-hydroxy-1H-carbazole-1,4(9H)-diones would be potent antifungal agents.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
authors.forename: Seung-Yon
authors.initials: SY
authors.lastname: Lee
authors.forename: Na Young
authors.initials: NY
authors.lastname: Kim
authors.forename: Jung An
authors.initials: JA
authors.lastname: Hong
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Yoon
authors.forename: Aram
authors.initials: A
authors.lastname: Kim
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002227:Carbazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D002227:Carbazoles