title: Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals.
abstract: The impact of pandemic (H1N1) 2009 influenza in HIV-infected individuals is unknown. Determining the prevalence of pandemic influenza in this at-risk group will guide vaccination programs. After the first pandemic wave, the seroprevalence rate of pandemic influenza in HIV-infected individuals in western Sydney, New South Wales, Australia, was 34.2%, similar to the rate observed in the general population. However, true seroprevalence is more accurately determined by seroconversion, defined as a 4-fold or greater rise between preexposure and postexposure antibody levels, which was 14.6% in the present study. Seroconversion rates were independent of CD4 T-lymphocyte count and HIV plasma load. Neither HIV infection, nor severe immunosuppression, was a significant risk factor for pandemic influenza during the first southern hemisphere pandemic wave.
authors.affiliation: Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia. jen.kok@swahs.health.nsw.gov.au
authors.forename: Jen
authors.initials: J
authors.lastname: Kok
authors.forename: Katherine
authors.initials: K
authors.lastname: Tudo
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Blyth
authors.forename: Hong
authors.initials: H
authors.lastname: Foo
authors.forename: Linda
authors.initials: L
authors.lastname: Hueston
authors.forename: Dominic E
authors.initials: DE
authors.lastname: Dwyer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D018791:CD4 Lymphocyte Count; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D019562:Viral Load; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral