title: [Therapy approaches for geographic atrophy].
abstract: Geographic atrophy, the dry form and late manifestation of age-related macular degeneration, is the next challenge following the breakthrough in the treatment of neovascular age-related macular degeneration (AMD). Various interventional pharmacologic approaches with different targets are already being tested in clinical interventional trials. These include reduction of retinal toxins, anti-inflammatory agents, complement inhibition, neuroprotection and alleviation of oxidative stress. Until efficacy and safety is demonstrated, aids for poor vision and further rehabilitative measures remain essential for patients with advanced dry AMD.
authors.affiliation: Universitäts-Augenklinik Bonn, Ernst-Abbe-Strasse 2, Bonn, Deutschland. steffen.schmitz-valckenberg@ukb.uni-bonn.de
authors.forename: S
authors.initials: S
authors.lastname: Schmitz-Valckenberg
authors.forename: A
authors.initials: A
authors.lastname: Mössner
authors.forename: M
authors.initials: M
authors.lastname: Fleckenstein
authors.forename: P
authors.initials: P
authors.lastname: Wiedemann
authors.forename: F G
authors.initials: FG
authors.lastname: Holz
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002352:Carrier Proteins / Q000037:antagonists & inhibitors; D002986:Clinical Trials as Topic; D051056:Complement Inactivating Agents / Q000627:therapeutic use; D005136:Eye Proteins / Q000037:antagonists & inhibitors; D017313:Fenretinide / Q000627:therapeutic use; D057092:Geographic Atrophy / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D014787:Vision Tests; D014801:Vitamin A / Q000097:blood; D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D051056:Complement Inactivating Agents; D005136:Eye Proteins; D017313:Fenretinide; D018696:Neuroprotective Agents; D044282:Receptor, Serotonin, 5-HT1A; D017366:Serotonin Receptor Agonists; D014801:Vitamin A; D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase