title: Zinc release of Zn₇-metallothionein-3 induces fibrillar type amyloid-β aggregates.
abstract: The reactive oxygen species H₂O₂ promotes the Zn₇-metallothionein-3 induced Aβ(40) aggregation of fibrillar type structures via slow cysteine oxidation and Zn(2+) release, whereas amorphous aggregates are formed by addition of Zn(2+) to Aβ(40).
authors.affiliation: Laboratoire de Chimie de Coordination, Centre National de la Recherche Scientifique, 205 route de Narbonne, 77 Toulouse, France.
authors.forename: Jade
authors.initials: J
authors.lastname: Durand
authors.forename: Gabriele
authors.initials: G
authors.lastname: Meloni
authors.forename: Christine
authors.initials: C
authors.lastname: Talmard
authors.forename: Milan
authors.initials: M
authors.lastname: Vašák
authors.forename: Peter
authors.initials: P
authors.lastname: Faller
mesh_terms: D000682:Amyloid / Q000187:drug effects / Q000378:metabolism*; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism; D000090023:Metallothionein 3; D046529:Microscopy, Electron, Transmission; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species; D021241:Spectrometry, Mass, Electrospray Ionization; D015032:Zinc / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000682:Amyloid; D000090023:Metallothionein 3; D009419:Nerve Tissue Proteins; D017382:Reactive Oxygen Species; D015032:Zinc; D003545:Cysteine