title: Development of a microbicide-releasing diaphragm as an HIV prevention strategy.
abstract: Contraceptive diaphragms offer a discreet method of pregnancy protection that women can use when needed with no side effects. Incorporating antiretroviral HIV microbicides into such devices may also provide protection against HIV infection. The paper gives a brief outline of the work being conducted by PATH, CONRAD and QUB on the development of a microbicide-releasing SILCS diaphragm. The design, engineering and manufacturing challenges that have been encountered will be discussed, as well as the potential impact such a device could have in the developing world.
authors.affiliation: School of Pharmacy, Queen's University Belfast, UK. i.major@qub.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Major
authors.forename: Deborah
authors.initials: D
authors.lastname: Lowry
authors.forename: Karl
authors.initials: K
authors.lastname: Malcolm
authors.forename: David
authors.initials: D
authors.lastname: Woolfson
authors.forename: Jessica
authors.initials: J
authors.lastname: Cohen
authors.forename: Paul
authors.initials: P
authors.lastname: Labarre
authors.forename: Maggie
authors.initials: M
authors.lastname: Kilbourne-Brook
authors.forename: Gene
authors.initials: G
authors.lastname: Saxon
authors.forename: David
authors.initials: D
authors.lastname: Friend
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000737:chemistry; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000737:chemistry; D003274:Contraceptive Devices, Female; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D019380:Anti-HIV Agents; D000891:Anti-Infective Agents, Local; D004343:Drug Implants