title: Autologous hematopoietic stem cell transplantation in type 1-diabetes.
abstract: A type 1-diabetes results from autoimmune destruction of the insulin producing ß-cells in the pancreas. Today there is no cure to the disorder, and the patients require life-long insulin medication to survive. Treatment with exogenous insulin cannot mimic the second-by second regulation of blood glucose levels achieved by the ß-cells, and the current regimen presents a difficult navigation between the Scylla of life-threatening hypoglycemia and the Charybdis of hyperglycemic tissue glycosylation and late-complications.
authors.affiliation: Lund University Diabetes Centre, Malmö, Sweden.
authors.forename: Anders H
authors.initials: AH
authors.lastname: Rosengren
authors.forename: Erik
authors.initials: E
authors.lastname: Renström
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods; D014182:Transplantation, Autologous
chemical_list: D007166:Immunosuppressive Agents