title: Flow optimization study of a batch microfluidics PET tracer synthesizing device.
abstract: We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.
authors.affiliation: Siemens Molecular Imaging, Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230, USA.
authors.forename: Arkadij M
authors.initials: AM
authors.lastname: Elizarov
authors.forename: Carl
authors.initials: C
authors.lastname: Meinhart
authors.forename: Reza
authors.initials: R
authors.lastname: Miraghaie
authors.forename: R Michael
authors.initials: RM
authors.lastname: van Dam
authors.forename: Jiang
authors.initials: J
authors.lastname: Huang
authors.forename: Antoine
authors.initials: A
authors.lastname: Daridon
authors.forename: James R
authors.initials: JR
authors.lastname: Heath
authors.forename: Hartmuth C
authors.initials: HC
authors.lastname: Kolb
mesh_terms: D007202:Indicators and Reagents / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D055616:Microtechnology / Q000379:methods*; D008962:Models, Theoretical; D049268:Positron-Emission Tomography; D011849:Radioactive Tracers
chemical_list: D007202:Indicators and Reagents; D011849:Radioactive Tracers