title: Reduction of a linear complex model for respiratory system during Airflow Interruption.
abstract: The paper presents methodology of a complex model reduction to its simpler version - an identifiable inverse model. Its main tool is a numerical procedure of sensitivity analysis (structural and parametric) applied to the forward linear equivalent designed for the conditions of interrupter experiment. Final result - the reduced analog for the interrupter technique is especially worth of notice as it fills a major gap in occlusional measurements, which typically use simple, one- or two-element physical representations. Proposed electrical reduced circuit, being structural combination of resistive, inertial and elastic properties, can be perceived as a candidate for reliable reconstruction and quantification (in the time and frequency domain) of dynamical behavior of the respiratory system in response to a quasi-step excitation by valve closure.
authors.affiliation: Department of Electronics, Wroclaw University of Technolgy, ul. B. Prusa 53/55, 50-317, Poland. irenuesz.jablonski@pwr.wroc.pl
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Jablonski
authors.forename: Janusz
authors.initials: J
authors.lastname: Mroczka
mesh_terms: D000403:Airway Resistance; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D006801:Humans; D016014:Linear Models; D008954:Models, Biological; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods*; D015656:Respiratory Mechanics; D012137:Respiratory System / Q000503:physiopathology*; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D012680:Sensitivity and Specificity