title: Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or high-grade precancerous lesions in Chengdu, western China.
abstract: OBJECTIVE
  To study the prevalence and genotype distribution of human papillomavirus (HPV) among women with cervical cancer or high-grade squamous intraepithelial lesions (HSIL) in western China.
  
  
  METHODS
  Cervical cast-off cells from 144 women with cervical cancer and 63 women with HSIL were tested for HPV genotypes using an oligonucleotide microarray.
  
  
  RESULTS
  The overall HPV prevalence was 80.6% in cases of carcinoma and 61.9% in cases of HSIL. The most common genotypes were HPV-16 (carcinoma, 68.1%; HSIL, 34.9%) and HPV-58 (carcinoma, 8.3%; HSIL, 17.5%). Other high-risk types included HPV-18, -31, -33, -35, -45, and -52, with HPV-18 more common in adenocarcinomas than in squamous cell carcinomas (21.4% vs 3.1%; P<0.02). The HPV prevalence was lower among patients older than 49 years (P<0.02).
  
  
  CONCLUSIONS
  The prevalence of HPV-16 and HPV-58 was high. This finding may help to improve HPV vaccination and cervical cancer prevention programs in western China.
authors.affiliation: Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, 20 Renmingnan Road, Chengdu, China.
authors.forename: Jinke
authors.initials: J
authors.lastname: Li
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.forename: Lina
authors.initials: L
authors.lastname: Hu
mesh_terms: D000230:Adenocarcinoma / Q000821:virology; D000328:Adult; D000367:Age Factors; D002294:Carcinoma, Squamous Cell / Q000821:virology; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D011230:Precancerous Conditions / Q000821:virology*; D015995:Prevalence; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D055815:Young Adult