title: The role of black rice (Oryza sativa L.) in the control of hypercholesterolemia in rats.
abstract: Cardiovascular disease is a serious public health problem; it is the first "cause of death" in Brazil and in developed countries. Thus, it is essential to search for alternative sources such as some functional foods to prevent and control the risks of this disease. The purpose of this study was to evaluate the lipidemic parameters in hypercholesterolemic rats fed diets containing black rice variety IAC 600 or unrefined rice. Adult male Wistar rats (Rattus norvegicus var. albinos) were used, weighing about 200-220 g. The animals were divided into four groups: the first received a control casein diet, the second received hypercholesterolemic diet, and the other two groups, after induction of hypercholesterolemia, received the test diets, the first containing 20% black rice and the second 20% unrefined, for 30 days. It was observed that diet containing black rice reduced the level of plasma cholesterol, triglycerides, and low-density lipoprotein. For high-density lipoprotein values, the diet that provided an increase in the levels was the black rice. The diet containing black rice was more effective in controlling the lipidemia in rats compared with the whole rice diet.
authors.affiliation: Department of Agroindustry, Food and Nutrition, Luiz de Queiroz College of Agriculture, University of São Paulo, Piracicaba, São Paulo, Brazil. jmsalgad@esalq.usp.br
authors.forename: Jocelem Mastrodi
authors.initials: JM
authors.lastname: Salgado
authors.forename: Anderson Giovanni Candido de
authors.initials: AG
authors.lastname: Oliveira
authors.forename: Débora Niero
authors.initials: DN
authors.lastname: Mansi
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Donado-Pestana
authors.forename: Candido Ricardo
authors.initials: CR
authors.lastname: Bastos
authors.forename: Fernanda Klein
authors.initials: FK
authors.lastname: Marcondes
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000009:adverse effects; D004043:Dietary Fiber / Q000032:analysis; D005243:Feces / Q000737:chemistry; D005419:Flavonoids / Q000032:analysis; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D012275:Oryza / Q000737:chemistry; D010636:Phenols / Q000032:analysis; D059808:Polyphenols; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D004041:Dietary Fats; D004043:Dietary Fiber; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D014280:Triglycerides; D002784:Cholesterol