title: Pleiotropic actions of fenofibrate on the heart.
abstract: Fenofibrate is a third-generation fibric acid derivative employed clinically as a hypolipidemic agent to lessen the risk caused by atherosclerosis. Dyslipidemia is a condition associated with elevated levels of low-density lipoproteins (LDL), very low-density lipoproteins (VLDL) and triglycerides, and reduced levels of high-density lipoproteins (HDL) in the circulation. Fenofibrate has an ability to diminish LDL, VLDL and triglycerides and pertinently augment HDL, and thus it is used to manage dyslipidemia. The lipid lowering effects of fenofibrate are classically mediated via an activation of peroxisome proliferator-activated receptor-alpha (PPAR-α). Recent studies demonstrated numerous pleiotropic effects of fenofibrate on the heart that afford direct myocardial protection besides its lipid lowering effects. Fenofibrate has an additional potential to prevent the induction and progression of hypertensive heart damage, cardiac hypertrophy, heart failure, myocarditis, lipotoxic cardiomyopathy and vascular endothelial dysfunction-associated cardiovascular abnormalities. In this review, we critically discussed recently identified pleiotropic actions of fenofibrate on the heart. Moreover, the novel cardioprotective effects of fenofibrate against various cardiac disorders have been delineated.
authors.affiliation: Department of Pharmacology, Institute of Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa-125055, India. pbala2006@gmail.com
authors.forename: Pitchai
authors.initials: P
authors.lastname: Balakumar
authors.forename: Ankur
authors.initials: A
authors.lastname: Rohilla
authors.forename: Nanjaian
authors.initials: N
authors.lastname: Mahadevan
mesh_terms: D000818:Animals; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D011345:Fenofibrate / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000960:Hypolipidemic Agents; D011345:Fenofibrate