title: Acute obstructive apnea produces natriuresis in spontaneously hypertensive rats (SHR) by a renal nerve-dependent.
abstract: The role of renal nerve in excretion was investigated during acute obstructive apnea (OA) episodes in SHR. The animals (SHR and control, C) were presented for renal denervation (D; CD; SHRD) or undenervation (U; CU; SHRU). Tracheal catheterization was performed to induce OA via its total occlusion. Urine samples were collected every 2 min after 20 s of OA. Obstructive apnea resulted in bradycardia, hypotension, and induced elevations in the urinary measurements in SHRU, but not in CU. Conversely, the denervation increased in CD, but not in the SHRD. Urinary excretion was dependent of renal nerve in SHR during OA.
authors.affiliation: Department of Pharmacy, University Center of Vila Velha, Vila Velha, Brazil.
authors.forename: Tadeu U
authors.initials: TU
authors.lastname: Andrade
authors.forename: João V M
authors.initials: JV
authors.lastname: Franquini
authors.forename: Antônio M
authors.initials: AM
authors.lastname: Cabral
authors.forename: Elisardo C
authors.initials: EC
authors.lastname: Vasquez
authors.forename: Maria T
authors.initials: MT
authors.lastname: Araújo
authors.forename: Margareth R
authors.initials: MR
authors.lastname: Moysés
authors.forename: Gláucia R
authors.initials: GR
authors.lastname: Abreu
authors.forename: Nazare S
authors.initials: NS
authors.lastname: Bissoli
mesh_terms: D000208:Acute Disease; D000818:Animals; D003714:Denervation; D004195:Disease Models, Animal; D004231:Diuresis / Q000502:physiology; D006439:Hemodynamics; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology; D008297:Male; D009318:Natriuresis / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology*