title: Managing fungal and viral infections in pediatric leukemia.
abstract: Despite steadily improving long-term outcomes, infections remain a major cause of morbidity and mortality in children receiving therapy for leukemia. Standardized approaches to the management of bacterial infections have been highly successful. However, management of fungal and viral infections remains challenging, especially given the shifting epidemiology of fungal infections. Significant advances in diagnostic and therapeutic modalities have been achieved for fungal and viral infections over the past decade, providing new opportunities for effective interventions. This article reviews the management of viral and fungal infections in children undergoing therapy for leukemia.
authors.affiliation: St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.
authors.forename: Hana
authors.initials: H
authors.lastname: Hakim
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Shenep
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D018890:Chemoprevention; D002648:Child; D005658:Fungi / Q000472:pathogenicity; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014777:Virus Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014780:Viruses / Q000472:pathogenicity
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents