title: Heart rate dynamics in temporal lobe epilepsy-A long-term follow-up study.
abstract: The aim of the present study was to prospectively evaluate long-term changes in interictal heart rate variability (HRV) in patients with temporal lobe epilepsy (TLE). A 24-h ECG was recorded at baseline and after a mean follow-up of 6.1 years in 18 patients with refractory TLE and 18 patients with well-controlled TLE. After the follow-up, the Poincaré components SD(1) (p=0.039) and SD(2) (p=0.001) were decreased in patients with refractory TLE compared to baseline, whereas in patients with well-controlled TLE no changes (p>0.05) in HR variability were observed. The reduction in HRV seems to be progressive in patients with chronic refractory TLE with recurrent seizures.
authors.affiliation: Department of Neurology, University of Oulu, Oulu, Finland. eronkain@paju.oulu.fi
authors.forename: Eija
authors.initials: E
authors.lastname: Suorsa
authors.forename: Juha T
authors.initials: JT
authors.lastname: Korpelainen
authors.forename: Hanna
authors.initials: H
authors.lastname: Ansakorpi
authors.forename: Heikki V
authors.initials: HV
authors.lastname: Huikuri
authors.forename: Ville
authors.initials: V
authors.lastname: Suorsa
authors.forename: Vilho V
authors.initials: VV
authors.lastname: Myllylä
authors.forename: Jouko I T
authors.initials: JI
authors.lastname: Isojärvi
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D004562:Electrocardiography / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D017711:Nonlinear Dynamics; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants