title: The role of the dorsolateral prefrontal cortex in deception when remembering neutral and emotional events.
abstract: We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of deception while remembering neutral events and emotional events. Before fMRI, subjects were presented with a series of neutral and emotional pictures and were asked to rate each picture for arousal. During fMRI, subjects were presented with the studied and nonstudied pictures and were asked to make an honest recognition judgment in response to half of the pictures and a dishonest response to the remaining half. We found that deception pertaining to the memory of neutral pictures was associated with increased activity in the bilateral dorsolateral prefrontal cortex, the left ventrolateral prefrontal cortex, and the left orbitofrontal cortex. We also found that deception while remembering emotional pictures was associated with increased activity in the bilateral dorsolateral prefrontal cortex. An overlapping activation between the two types of deception was found in the bilateral dorsolateral prefrontal cortex. Our results indicate that the dorsolateral prefrontal cortex is associated with the executive aspects of deception, regardless of the emotional valence of memory content.
authors.affiliation: Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. ito-a@med.tohoku.ac.jp
authors.forename: Ayahito
authors.initials: A
authors.lastname: Ito
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Abe
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Fujii
authors.forename: Aya
authors.initials: A
authors.lastname: Ueno
authors.forename: Yuta
authors.initials: Y
authors.lastname: Koseki
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Shunji
authors.initials: S
authors.lastname: Mugikura
authors.forename: Shoki
authors.initials: S
authors.lastname: Takahashi
authors.forename: Etsuro
authors.initials: E
authors.lastname: Mori
mesh_terms: D000328:Adult; D001931:Brain Mapping; D008192:Deception; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D055815:Young Adult