title: Mefloquine treatment in a patient suffering from progressive multifocal leukoencephalopathy after umbilical cord blood transplant.
abstract: We report herein the case of a 37-year-old man who developed probable progressive multifocal leukoencephalopathy (PML) following an umbilical cord blood transplant. The patient showed favorable clinical, neuroradiological and virological responses after treatment with mefloquine, an anti-malarial drug. Mefloquine may offer some benefits as a treatment for PML in patients with or without human immunodeficiency virus type-1 infection. This report highlights the need to gather sufficient data to confirm the efficacy of mefloquine against this devastating viral disease of the central nervous system.
authors.affiliation: Division of Neurology, Tokyo Metropolitan Cancer and Infectious Disease Center-Komagome Hospital, Tokyo, Japan. s-kisida@cick.jp
authors.forename: Shuji
authors.initials: S
authors.lastname: Kishida
authors.forename: Kozue
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D015767:Mefloquine / Q000627:therapeutic use*
chemical_list: D015767:Mefloquine