title: A new and efficient synthetic route for the anxiolytic agent CL285032.
abstract: CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.
authors.affiliation: Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA.
authors.forename: Victor P
authors.initials: VP
authors.lastname: Ghidu
authors.forename: Marc A
authors.initials: MA
authors.lastname: Ilies
authors.forename: Tom
authors.initials: T
authors.lastname: Cullen
authors.forename: Robert
authors.initials: R
authors.lastname: Pollet
authors.forename: Magid
authors.initials: M
authors.lastname: Abou-Gharbia
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004285:Dogs; D010698:Phobic Disorders / Q000188:drug therapy; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; C557261:CL285032; D011724:Pyridazines; C062482:pyridazine