title: Extending CATH: increasing coverage of the protein structure universe and linking structure with function.
abstract: CATH version 3.3 (class, architecture, topology, homology) contains 128,688 domains, 2386 homologous superfamilies and 1233 fold groups, and reflects a major focus on classifying structural genomics (SG) structures and transmembrane proteins, both of which are likely to add structural novelty to the database and therefore increase the coverage of protein fold space within CATH. For CATH version 3.4 we have significantly improved the presentation of sequence information and associated functional information for CATH superfamilies. The CATH superfamily pages now reflect both the functional and structural diversity within the superfamily and include structural alignments of close and distant relatives within the superfamily, annotated with functional information and details of conserved residues. A significantly more efficient search function for CATH has been established by implementing the search server Solr (http://lucene.apache.org/solr/). The CATH v3.4 webpages have been built using the Catalyst web framework.
authors.affiliation: Institute of Structural and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. cuff@biochem.ucl.ac.uk
authors.forename: Alison L
authors.initials: AL
authors.lastname: Cuff
authors.forename: Ian
authors.initials: I
authors.lastname: Sillitoe
authors.forename: Tony
authors.initials: T
authors.lastname: Lewis
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Clegg
authors.forename: Robert
authors.initials: R
authors.lastname: Rentzsch
authors.forename: Nicholas
authors.initials: N
authors.lastname: Furnham
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Pellegrini-Calace
authors.forename: David
authors.initials: D
authors.lastname: Jones
authors.forename: Janet
authors.initials: J
authors.lastname: Thornton
authors.forename: Christine A
authors.initials: CA
authors.lastname: Orengo
mesh_terms: D030562:Databases, Protein; D010802:Phylogeny; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000145:classification
chemical_list: D011506:Proteins