title: Distinct cytokine patterns associated with different forms of chronic dysimmune neuropathy.
abstract: To better understand the presumed immune system dysregulation of chronic dysimmune neuropathy (CDN) patients, we designed a study to evaluate the levels of pro- and anti-inflammatory cytokines in the most common forms of CDN: chronic inflammatory demyelinating polyneuropathy (CIDP), and anti-myelin-associated glycoprotein (MAG)-related polyneuropathy (MAGnp). Sixteen patients fulfilled diagnostic criteria for CIDP, 14 were diagnosed with MAGnp, and 36 were classified as exhibiting "chronic idiopathic polyneuropathy" (CIP). Cytokine production in mitogen-stimulated peripheral blood mononuclear cells (PBMCs) was analyzed by flow cytometry. CIDP and MAGnp patients were compared with CIP patients, those with monoclonal gammopathy without polyneuropathy (MGUS), and healthy controls (HC). We observed an increase in pro-inflammatory cytokines in the CIDP group, whereas interleukin-10 (IL-10) was augmented in the MAGnp patients. These distinctive immune alterations may represent a biological tool in differential diagnosis and future therapeutic approaches.
authors.affiliation: Department of Neurology, Don C. Gnocchi Foundation IRCCS, Milan, Italy.
authors.forename: Maira
authors.initials: M
authors.lastname: Gironi
authors.forename: Marina
authors.initials: M
authors.lastname: Saresella
authors.forename: Ivana
authors.initials: I
authors.lastname: Marventano
authors.forename: Franca Rosa
authors.initials: FR
authors.lastname: Guerini
authors.forename: Andrea
authors.initials: A
authors.lastname: Gatti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Antonini
authors.forename: Lara
authors.initials: L
authors.lastname: Ceresa
authors.forename: Stefania
authors.initials: S
authors.lastname: Morino
authors.forename: Ettore
authors.initials: E
authors.lastname: Beghi
authors.forename: Alberto
authors.initials: A
authors.lastname: Angelici
authors.forename: Enrica
authors.initials: E
authors.lastname: Mariani
authors.forename: Raffaello
authors.initials: R
authors.lastname: Nemni
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood / Q000276:immunology*; D011115:Polyneuropathies / Q000097:blood / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016207:Cytokines