title: A comparative analysis shows morphofunctional differences between the rat and mouse melanin-concentrating hormone systems.
abstract: Sub-populations of neurons producing melanin-concentrating hormone (MCH) are characterized by distinct projection patterns, birthdates and CART/NK3 expression in rat. Evidence for such sub-populations has not been reported in other species. However, given that genetically engineered mouse lines are now commonly used as experimental models, a better characterization of the anatomy and morphofunctionnal organization of MCH system in this species is then necessary. Combining multiple immunohistochemistry experiments with in situ hybridization, tract tracing or BrdU injections, evidence supporting the hypothesis that rat and mouse MCH systems are not identical was obtained: sub-populations of MCH neurons also exist in mouse, but their relative abundance is different. Furthermore, divergences in the distribution of MCH axons were observed, in particular in the ventromedial hypothalamus. These differences suggest that rat and mouse MCH neurons are differentially involved in anatomical networks that control feeding and the sleep/wake cycle.
authors.affiliation: Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Croizier
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Franchi-Bernard
authors.forename: Claude
authors.initials: C
authors.lastname: Colard
authors.forename: Fabrice
authors.initials: F
authors.lastname: Poncet
authors.forename: Annie
authors.initials: A
authors.lastname: La Roche
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Risold
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D007028:Hypothalamic Hormones / Q000235:genetics / Q000378:metabolism*; D007031:Hypothalamus / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008543:Melanins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010907:Pituitary Hormones / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans; D018042:Receptors, Neurokinin-3 / Q000378:metabolism*; D013045:Species Specificity; D013997:Time Factors; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
chemical_list: D007028:Hypothalamic Hormones; D008543:Melanins; D009419:Nerve Tissue Proteins; D010907:Pituitary Hormones; D018042:Receptors, Neurokinin-3; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; C019463:melanin-concentrating hormone