title: Novel polymeric vesicles with pH-induced deformation character for advanced drug delivery.
abstract: pH-responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lipophilic and hydrophilic molecules. The pH-dependent structure change of vesicles was also observed by DLS and TEM. Dox-loaded vesicles exhibit a sharp pH-responsive drug release profile and dramatically enhance the cytotoxicity of Dox against Dox-resistant MCF-7/adr cells. These results suggest such vesicles based on pH-responsive polyphosphazene hold great potential for specific drug therapy.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zheng
authors.forename: Xiaping
authors.initials: X
authors.lastname: Yao
authors.forename: Liyan
authors.initials: L
authors.lastname: Qiu
mesh_terms: D045744:Cell Line, Tumor; D003911:Dextrans / Q000378:metabolism; D003956:Dialysis; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D016650:Fluorescein-5-isothiocyanate / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012542:Scattering, Radiation
chemical_list: D003911:Dextrans; D004337:Drug Carriers; D009943:Organophosphorus Compounds; D011108:Polymers; C108974:poly(phosphazene); D016650:Fluorescein-5-isothiocyanate