title: Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines.
abstract: An unprecedented NH(2)-directed Pd(II)-catalytic carbonylation of quaternary aromatic α-amino esters to yield 6-membered benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process.
authors.affiliation: Departament de Química Orgànica and IBUB, Fac. Química, Universitat de Barcelona, Martí i Franquès 1, 08028-Barcelona, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: López
authors.forename: Aleix
authors.initials: A
authors.lastname: Rodriguez
authors.forename: David
authors.initials: D
authors.lastname: Santos
authors.forename: Joan
authors.initials: J
authors.lastname: Albert
authors.forename: Xavier
authors.initials: X
authors.lastname: Ariza
authors.forename: Jordi
authors.initials: J
authors.lastname: Garcia
authors.forename: Jaume
authors.initials: J
authors.lastname: Granell