title: Conduction abnormalities in the right ventricular outflow tract in Brugada syndrome detected body surface potential mapping.
abstract: Brugada syndrome (BrS) causes sudden death in patients with structurally normal hearts. Manifestation of BrS in the ECG is dynamical and most patients do not show unequivocal signs of the syndrome during ECG screening. We have obtained 67-lead body surface potential mapping recordings of 25 patients with BrS and analyzed their spatial distribution of surface potentials during ventricular activation. Six patients presented spontaneous type I ECGs during the recording. These patients showed non-dipolarities in isopotential maps at the right ventricular outflow tract (RVOT) region during the development of terminal R waves in right precordial leads. Same finding was observed in 95% of BrS patients not presenting a type I ECG. Conduction delay in the RVOT may be a consistent finding in BrS patients that can be identified by Body Surface Potential Mapping.
authors.affiliation: BIO-ITACA at Universidad Politécnica de Valencia, 46022, Spain. mguisan@eln.upv.es
authors.forename: Maria S
authors.initials: MS
authors.lastname: Guillem
authors.forename: Andreu M
authors.initials: AM
authors.lastname: Climent
authors.forename: Jose
authors.initials: J
authors.lastname: Millet
authors.forename: Paola
authors.initials: P
authors.lastname: Berne
authors.forename: Rafael
authors.initials: R
authors.lastname: Ramos
authors.forename: Josep
authors.initials: J
authors.lastname: Brugada
authors.forename: Ramon
authors.initials: R
authors.lastname: Brugada
mesh_terms: D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D018780:Body Surface Potential Mapping / Q000379:methods*; D053840:Brugada Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D002037:Bundle-Branch Block / Q000175:diagnosis / Q000503:physiopathology; D004452:Echocardiography / Q000379:methods*; D004566:Electrodes; D022062:Electrophysiologic Techniques, Cardiac; D006329:Heart Conduction System / Q000502:physiology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted