title: Ultrasound assisted dehydrogenation of 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides.
abstract: Dehydrogenation of various 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides (THPMs) to 2-oxo-1,2-dihydropyrimidine-5-carboxamides (DHPMs) using tetrabutylammonium peroxydisulfate (TBAPS) as an efficient oxidizing agent under thermal and sono-thermal conditions has been investigated. In contrast to the thermal reaction, a decrease of the amount of oxidant and an increase of the rate of reaction are observed by simultaneously applying heat and ultrasound. The nature of both C-4 and C-5 substituents on the heterocyclic ring influences the rate of reaction under both conditions. The proposed electron-transfer-induced dehydrogenation in this study is supported by conductometric studies.
authors.affiliation: Catalysis Division, Department of Chemistry, Faculty of Science, University of Isfahan, Isfahan, Iran. memarian@sci.ui.ac.ir
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Memarian
authors.forename: Mousa
authors.initials: M
authors.lastname: Soleymani
mesh_terms: D000577:Amides / Q000737:chemistry; D004579:Electron Transport; D006865:Hydrogenation; D007700:Kinetics; D016877:Oxidants / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D013696:Temperature; D014465:Ultrasonics
chemical_list: D000577:Amides; D016877:Oxidants; D011743:Pyrimidines