title: Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo.
abstract: Nanoparticle-based therapeutics with local delivery and external electromagnetic field modulation holds extraordinary promise for soft-tissue cancers such as breast cancer; however, knowledge of the distribution and fate of nanoparticles in vivo is crucial for clinical translation. Here we demonstrate that multiple diagnostic capabilities can be introduced in photothermal therapeutic nanocomplexes by simultaneously enhancing both near-infrared fluorescence and magnetic resonance imaging (MRI). We track nanocomplexes in vivo, examining the influence of HER2 antibody targeting on nanocomplex distribution over 72 h. This approach provides valuable, detailed information regarding the distribution and fate of complex nanoparticles designed for specific diagnostic and therapeutic functions.
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas 77005, United States.
authors.forename: Rizia
authors.initials: R
authors.lastname: Bardhan
authors.forename: Wenxue
authors.initials: W
authors.lastname: Chen
authors.forename: Marc
authors.initials: M
authors.lastname: Bartels
authors.forename: Carlos
authors.initials: C
authors.lastname: Perez-Torres
authors.forename: Maria F
authors.initials: MF
authors.lastname: Botero
authors.forename: Robin Ward
authors.initials: RW
authors.lastname: McAninch
authors.forename: Alejandro
authors.initials: A
authors.lastname: Contreras
authors.forename: Rachel
authors.initials: R
authors.lastname: Schiff
authors.forename: Robia G
authors.initials: RG
authors.lastname: Pautler
authors.forename: Naomi J
authors.initials: NJ
authors.lastname: Halas
authors.forename: Amit
authors.initials: A
authors.lastname: Joshi
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000628:therapy*; D045744:Cell Line, Tumor; D004574:Electromagnetic Fields; D005260:Female; D005453:Fluorescence; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles; D019265:Spectroscopy, Near-Infrared