title: Prevention of postoperative pericardial adhesions in children with hypoplastic left heart syndrome.
abstract: Reoperations for congenital cardiac defects are associated with an increased surgical risk due to adhesions. We compared the capability of a polytetrafluoroethylene (PTFE) membrane, synthetic polyethyleneglycol hydrogel (PEG), and a combination of them to prevent postoperative pericardial adhesions in patients with hypoplastic left heart syndrome (HLHS). Eighteen consecutive patients with HLHS were included. At the end of the Norwood I operation the cranial and the caudal half of the heart of each patient was randomized to receive a PTFE membrane, a synthetic PEG, a combination of them, or no treatment (control). Tenacity and density of adhesions, epicardial visibility, and adhesions between the heart and the sternum were analyzed semiquantitatively at a subsequent bidirectional Glenn operation. The PTFE membrane significantly decreased adhesion formation between the heart and the sternum (P<0.001). However, the PTFE membrane, with or without synthetic PEG, impaired epicardial visibility (P<0.05) when compared to synthetic PEG or controls. Synthetic PEG alone did not significantly reduce the formation of pericardial adhesions. Tenacity and density of adhesions were not affected by any of the treatment modalities. The PTFE membrane significantly decreases postoperative adhesions between the heart and the sternum, but impairs epicardial visibility. Synthetic PEG does not prevent formation of pericardial adhesions.
authors.affiliation: Department of Paediatric Cardiac Surgery, Hospital for Children and Adolescents, University of Helsinki, P.O.B. 281, 00029 Helsinki, Finland. jukka.salminen@hus.fi
authors.forename: Jukka T
authors.initials: JT
authors.lastname: Salminen
authors.forename: Ilkka P
authors.initials: IP
authors.lastname: Mattila
authors.forename: Juha T
authors.initials: JT
authors.lastname: Puntila
authors.forename: Heikki I
authors.initials: HI
authors.lastname: Sairanen
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020100:Hydrogels / Q000494:pharmacology*; D018636:Hypoplastic Left Heart Syndrome / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D007223:Infant; D008297:Male; D010496:Pericardium / Q000473:pathology*; D011138:Polytetrafluoroethylene / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D015996:Survival Rate; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D020100:Hydrogels; D011138:Polytetrafluoroethylene