title: Late complications after hematopoietic stem cell transplantation.
abstract: Hematopoietic stem cell transplantation (HSCT) offers the opportunity for cure to patients with leukemia, lymphoma and severe non-malignant diseases. More than 40,000 HSCTs are performed annually worldwide. Therefore, the number of long-term survivors, free of the disease for which they were transplanted is continuously increasing. Despite the improved prognosis of HSCT, long-term outcome may be impaired by transplant-associated morbidity and mortality. Long-term survivors can present a variety of malignant and non-malignant complications, impairing physical and psychological performance, normal integration in family and social life, and quality of life. Conditioning regimens, particularly when including total-body irradiation as well as graft-versus-host disease, play a key role in the development of late effects. However, with increasing time since transplantation new types of late effects may emerge. Awareness on long-term effects after HSCT is crucial to provide adapted pretransplant counseling, and recommendations for post-transplant screening, prevention and early treatment.
authors.affiliation: Hematology Department, University Hospital, Petersgraben 4, Basel, Switzerland. tichelli@datacomm.ch
authors.forename: André
authors.initials: A
authors.lastname: Tichelli
authors.forename: Alicia
authors.initials: A
authors.lastname: Rovó
authors.forename: Jakob
authors.initials: J
authors.lastname: Passweg
authors.forename: Carl Philipp
authors.initials: CP
authors.lastname: Schwarze
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Van Lint
authors.forename: Mutlu
authors.initials: M
authors.lastname: Arat
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
mesh_terms: D001847:Bone Diseases / Q000209:etiology / Q000517:prevention & control; D001989:Bronchiolitis Obliterans / Q000209:etiology / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D002493:Central Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D004700:Endocrine System Diseases / Q000209:etiology / Q000517:prevention & control; D006058:Gonadal Disorders / Q000209:etiology / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control; D008107:Liver Diseases / Q000175:diagnosis / Q000517:prevention & control; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control