title: Enantioseparation of rabeprazole and omeprazole by nonaqueous capillary electrophoresis with an ephedrine-based ionic liquid as the chiral selector.
abstract: An ephedrine-based chiral ionic liquid, (+)-N,N-dimethylephedrinium-bis(trifluoromethanesulfon)imidate ([DMP](+) [Tf(2) N](-) ), served as both chiral selector and background electrolyte in nonaqueous capillary electrophoresis. The enantioseparation of rabeprazole and omeprazole was achieved in acetonitrile-methanol (60:40 v/v) containing 60 mm[DMP](+) [Tf(2) N](-) . The influences of separation conditions, including the concentration of [DMP](+) [Tf(2) N](-) , the electrophoretic media and the buffer, on enantioseparation were evaluated. The mechanism of enantioseparation was investigated and discussed. Ion-pair interaction and hydrogen bonding may be responsible for the main separation mechanism.
authors.affiliation: Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ma
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhang
authors.forename: Lina
authors.initials: L
authors.lastname: Lin
authors.forename: Ping
authors.initials: P
authors.lastname: Ji
authors.forename: Xingjie
authors.initials: X
authors.lastname: Guo
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000737:chemistry / Q000302:isolation & purification*; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D004809:Ephedrine / Q000737:chemistry*; D006860:Hydrogen Bonding; D052578:Ionic Liquids; D009853:Omeprazole / Q000737:chemistry / Q000302:isolation & purification*; D064750:Rabeprazole; D013237:Stereoisomerism
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D052578:Ionic Liquids; D064750:Rabeprazole; D004809:Ephedrine; D009853:Omeprazole