title: The Rag4 glucose sensor is involved in the hypoxic induction of KlPDC1 gene expression in the yeast Kluyveromyces lactis.
abstract: Kluyveromyces lactis is a yeast which cannot grow under strict anaerobiosis. To date, no factors responsible for oxygen sensing and oxygen-dependent regulation of metabolism have been identified. In this paper we present the identification of the glucose sensor Rag4 as a factor essential for oxygen-dependent regulation of the fermentative pathway.
authors.affiliation: Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, 00185 Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Micolonghi
authors.forename: M
authors.initials: M
authors.lastname: Wésolowski-Louvel
authors.forename: M M
authors.initials: MM
authors.lastname: Bianchi
mesh_terms: D000693:Anaerobiosis; D005656:Fungal Proteins / Q000378:metabolism*; D017930:Genes, Reporter; D007716:Kluyveromyces / Q000235:genetics* / Q000378:metabolism; D007763:Lac Operon; D009154:Mutation; D011401:Promoter Regions, Genetic; D011767:Pyruvate Decarboxylase / Q000096:biosynthesis / Q000235:genetics*; D015533:Transcriptional Activation / Q000502:physiology; D001616:beta-Galactosidase / Q000096:biosynthesis
chemical_list: D005656:Fungal Proteins; C435343:RAG4 protein, Kluyveromyces; D001616:beta-Galactosidase; D011767:Pyruvate Decarboxylase