title: Small bowel tissue concentration of rebamipide: study of two dosages in healthy subjects.
abstract: Non-steroidal anti-inflammatory drug (NSAID)-related small intestinal complications exist, since developed new diagnostic modalities, such as balloon and capsule endoscopies. Some experiments have shown rebamipide to protect from NSAID-induced small intestinal complications. The purpose of this study is to investigate whether the effective concentrations of rebamipide (COR) are present in the small intestine after taking an ordinary clinical dose and double dose of this drug. Twelve healthy male subjects were enrolled. After taking 100 or 200 mg of rebamipide, balloon enteroscopy was performed at 1 and 3 h, and biopsy samples were obtained from the jejunum and the stomach. Venous blood samples were taken simultaneously. Samples were analyzed by high-performance liquid chromatography. The mean COR in the jejunum was higher than 100 µM at 1 h and higher than 10 µM at 3 h in both the 100 and 200 mg groups. Mean COR in the stomach was less than 100 µM at 1 h in the 100 mg group; however it was higher than 100 µM in the 200 mg group. In conclusion, the COR level in the jejunum was sufficient to protect for NSAID-induced gastrointestinal complications.
authors.affiliation: Endoscopy Center, Nagano Prefectural Hospital Organization, Suzaka Hospital, 1332 Suzaka, Suzaka, Nagano 382-0091, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Akamatsu
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Nagaya
authors.forename: Shinya
authors.initials: S
authors.lastname: Ichikawa
authors.forename: Takamori
authors.initials: T
authors.lastname: Sudo
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Takeda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takenaka
authors.forename: Ryo
authors.initials: R
authors.lastname: Kodama
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Norikazu
authors.initials: N
authors.lastname: Arakura
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka