title: Rapid correction of bone mass after parathyroidectomy in an adolescent with primary hyperparathyroidism.
abstract: BACKGROUND
  Primary hyperparathyroidism is rare in children. Absence of specific symptoms and limited biochemical evaluation in children has led to lengthy delays in diagnosis with the potential for damage to the kidneys and skeleton.
  
  
  METHODS
  The setting involved a private practice referral to a large tertiary care center.
  
  
  METHODS
  Our patient is a 16-yr-old male presenting with gross hematuria, left flank pain, and right foot pain.
  
  
  METHODS
  A biochemical evaluation revealed hypercalcemia and elevated parathyroid hormone levels. Renal ultrasonography demonstrated bilateral nephrolithiasis. Parathyroid ultrasonography and dual-phase technetium-99m sestamibi scintigraphy revealed a parathyroid adenoma in the left mid/lower anterior thyroid bed. A 4.5-g adenoma was removed at parathyroidectomy.
  
  
  METHODS
  Bone mineral content and density performed by dual energy X-ray absorptiometry at the time of diagnosis and 1 yr after parathyroidectomy.
  
  
  RESULTS
  The main outcome measurement is a dramatic (24%-whole body and 49.9%-left hip) increase in bone mineral density during the 1-yr interval.
  
  
  CONCLUSIONS
  Delay in diagnosis of hyperparathyroidism is common in children, related to vague symptomatology and infrequent use of laboratory evaluations in children. Such delays lead to increased risk of osteoporotic fractures and kidney stones. This case illustrates the emergent need of diagnostic evaluation in children presenting with similar symptoms. We emphasize the importance of bone densitometry in children, which is not often considered as part of the standard evaluation in this age group. The remarkable increase in bone mineral density in the 1 yr after surgery attests to the plasticity of recovery of the growing skeleton.
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8064, USA.
authors.forename: Michelle B
authors.initials: MB
authors.lastname: Vanstone
authors.forename: Robert D
authors.initials: RD
authors.lastname: Udelsman
authors.forename: David W
authors.initials: DW
authors.lastname: Cheng
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Carpenter
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D015502:Absorptiometry, Photon; D000236:Adenoma / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D006869:Hydronephrosis / Q000150:complications / Q000000981:diagnostic imaging; D049950:Hyperparathyroidism, Primary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D007668:Kidney / Q000000981:diagnostic imaging; D007669:Kidney Calculi / Q000150:complications / Q000000981:diagnostic imaging; D008096:Lithotripsy; D008297:Male; D010146:Pain / Q000209:etiology; D010282:Parathyroid Neoplasms / Q000473:pathology / Q000601:surgery; D016105:Parathyroidectomy; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013131:Spine / Q000473:pathology; D017256:Technetium Tc 99m Sestamibi; D014129:Trabecular Meshwork / Q000473:pathology; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D015652:25-Hydroxyvitamin D 2; D017256:Technetium Tc 99m Sestamibi