title: The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs.
abstract: T cells encounter their cognate antigens in specialized compartments of secondary lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T cells, and promote immunity or tolerance depending on the availability of danger signals. Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting them to T cell zones and guiding their migration within SLOs. Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses.
authors.affiliation: Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA. shannon_turley@dfci.harvard.edu
authors.forename: Shannon J
authors.initials: SJ
authors.lastname: Turley
authors.forename: Anne L
authors.initials: AL
authors.lastname: Fletcher
authors.forename: Kutlu G
authors.initials: KG
authors.lastname: Elpek
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D006413:Hematopoietic System / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D017154:Stromal Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000941:Antigens