title: Novel gemini cationic surfactants based on N, N-dimethyl fatty hydrazide and 1,3-dibromopropane: synthesis, evaluation of surface and antimicrobial properties.
abstract: A fatty hydrazide based cationic gemini surfactants, 1,3-bis (N'-acyl-N,N-dimethylhydrazinium) propane dibromide which possess hydrolyzable amido moieties in the lipophilic portions, were prepared by reacting 1,3-bromopropane with N,N-dimethyl fatty hydrazide. The surface properties were explained and discussed based on the effect of their chemical structures. The micelle-forming ability, foaming ability, and foam stability were evaluated. The prepared surfactants also showed some antimicrobial activity against gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) but they were not active against gram negative bacteria (Escherichia coli, P. aeruginosa), yeast (Candida albicans), and molds (Aspergillus niger).
authors.affiliation: Chemistry Department, Faculty of science, Al-Azhar University (Girls), Egypt. entsar_badr@yahoo.com.sg
authors.forename: E E
authors.initials: EE
authors.lastname: Badr
authors.forename: E M
authors.initials: EM
authors.lastname: Kandeel
authors.forename: B M
authors.initials: BM
authors.lastname: El-Sadek
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D002412:Cations / Q000737:chemistry; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008823:Micelles; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism; D013500:Surface Tension; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002412:Cations; D006834:Hydrazines; D008823:Micelles; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D011407:Propane; C032699:1,3-dibromopropane