title: Assessment of the genotoxic, antigenotoxic, and cytotoxic activities of the ethanolic fruit extract of Solanum lycocarpum A. St. Hill. (Solanaceae) by micronucleus test in mice.
abstract: Solanum lycocarpum A. St. Hill. (Family Solanaceae), popularly known in Brazil as lobeira, is a common weed in the Brazilian Cerrado vegetation. The fruits of this species have been used in Brazil for culinary purposes and in folk medicine as a sedative, diuretic, antiepileptic, antispasmodic, hypoglycemic, and hypocholesterolemic agent as well as in the control of obesity. Due to the spreading use of this plant as a therapeutic resource and food, the present study aimed to evaluate the genotoxic, antigenotoxic, and cytotoxic effects of S. lycocarpum ethanolic fruit extract using the mouse bone marrow micronucleus test. Both genotoxicity and antigenotoxicity of this ethanolic fruit extract were evaluated by using the frequency of micronucleated polychromatic erythrocytes, whereas cytotoxicity was assessed by the polychromatic and normochromatic erythrocytes ratio. Our results indicated that although S. lycocarpum ethanolic fruit extract did not exhibit genotoxic effect in mice bone marrow, both cytotoxic and antigenotoxic actions were evidenced at all tested doses.
authors.affiliation: Department of General Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás, Brazil.
authors.forename: Pabline Marinho
authors.initials: PM
authors.lastname: Vieira
authors.forename: Paula Moiana da
authors.initials: PM
authors.lastname: Costa
authors.forename: Carolina
authors.initials: C
authors.lastname: Ribeiro e Silva
authors.forename: Lee
authors.initials: L
authors.lastname: Chen-Chen
mesh_terms: D000465:Algorithms; D000818:Animals; D021461:Animals, Outbred Strains; D016587:Antimutagenic Agents / Q000494:pharmacology* / Q000633:toxicity; D001854:Bone Marrow Cells / Q000187:drug effects; D001938:Brazil; D003603:Cytotoxins / Q000494:pharmacology / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry*; D008297:Male; D008519:Medicine, Traditional / Q000009:adverse effects; D051379:Mice; D015162:Micronucleus Tests; D016685:Mitomycin / Q000037:antagonists & inhibitors / Q000633:toxicity; D009153:Mutagens / Q000494:pharmacology / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity*; D011897:Random Allocation; D032322:Solanum / Q000737:chemistry*; D023382:Toxicity Tests, Acute
chemical_list: D016587:Antimutagenic Agents; D003603:Cytotoxins; D009153:Mutagens; D010936:Plant Extracts; D016685:Mitomycin