title: [Experimental sensorineural loss of hearing of ototoxic origin in animals: apoptotic mechanism of cell death in the spiral organ].
abstract: This morphological study was carried out using white rats with experimental sensorineural loss of hearing. A method for simulation of ototoxic loss of hearing in laboratory animals is proposed. Investigations with the use of light microscopy revealed elements of the apoptotic mechanism of cell death in the spiral organ of rats with sensorineural loss of hearing. It was shown that application of methods designed to influence the mechanisms involved in regulation of apoptosis in animals with experimental sensorineural loss of hearing either prevents or decreases the death of neuroepithelial and auxiliary cells of the spiral organ.
authors.forename: T V
authors.initials: TV
authors.lastname: Zolotova
authors.forename: S N
authors.initials: SN
authors.lastname: Panchenko
mesh_terms: D000818:Animals; D017209:Apoptosis; D004195:Disease Models, Animal; D005839:Gentamicins / Q000633:toxicity; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000473:pathology*; D007103:Immobilization / Q000009:adverse effects; D009925:Organ of Corti / Q000187:drug effects* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005839:Gentamicins