title: In vivo effects of pentoxifylline on enzyme and non-enzyme antioxidant levels in rat liver after carrageenan-induced paw inflammation.
abstract: The present study aimed to investigate the effects of pentoxifylline (PTX) on the carrageenan (CG)-induced paw oedema and on the endogenous levels of cell enzyme and non-enzyme antioxidants in rat liver, 4 and 24 h after CG injection. PTX (50 mg kg(-1) , i.p.), administered 30 min before CG, decreased the paw oedema, 2-4 h after CG administration. The drug protected CG-induced decrease of glutathione (non-enzyme antioxidant) and had no effect on CG-unchanged activities of superoxide dismutase, glutathione peroxidase (enzyme antioxidants) and glucose-6-phosphate dehydrogenase (enzyme, important for the activity of GSH-conjugated antioxidant enzymes). The drug showed a good antioxidant capacity in chemical systems, generating reactive oxygen species. The present results suggest that the antioxidant activity of PTX might contribute to its beneficial effects in liver injuries.
authors.affiliation: Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Stefani
authors.initials: S
authors.lastname: Vircheva
authors.forename: Albena
authors.initials: A
authors.lastname: Alexandrova
authors.forename: Almira
authors.initials: A
authors.lastname: Georgieva
authors.forename: Polina
authors.initials: P
authors.lastname: Mateeva
authors.forename: Rositza
authors.initials: R
authors.lastname: Zamfirova
authors.forename: Marta
authors.initials: M
authors.lastname: Kubera
authors.forename: Margarita
authors.initials: M
authors.lastname: Kirkova
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D016166:Free Radical Scavengers; D006614:Hindlimb; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D002351:Carrageenan; D010431:Pentoxifylline