title: Distribution of model-based multipoint heterogeneity lod scores.
abstract: The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ(2) approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution ½χ²₀+ ½χ²₁, which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies.
authors.affiliation: Department of Clinical Sciences, McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. chao.xing@utsouthestern.edu
authors.forename: Chao
authors.initials: C
authors.lastname: Xing
authors.forename: Nathan
authors.initials: N
authors.lastname: Morris
authors.forename: Guan
authors.initials: G
authors.lastname: Xing
mesh_terms: D003198:Computer Simulation; D005799:Genes, Dominant; D005808:Genes, Recessive; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D015233:Models, Statistical; D016008:Statistical Distributions