title: A two-step, one-pot enzymatic synthesis of 2-substituted 1,3-diols.
abstract: A biocatalytic cascade reaction was designed for the stereoselective synthesis of optically pure 2-alkyl-1,3-diols employing two enzymes. The cascade process consists of two consecutive steps: a stereoselective diketone reduction and a hydroxy ketone reduction. Chiral diols were formed by the addition of ketoreductases in the same vessel, in high stereoselectivity and chemical yield, without the isolation of the intermediate β-hydroxy ketones.
authors.affiliation: Department of Chemistry, University of Crete, Heraklion 71003, Crete, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kalaitzakis
authors.forename: Ioulia
authors.initials: I
authors.lastname: Smonou
mesh_terms: D000429:Alcohol Oxidoreductases / Q000737:chemistry*; D000438:Alcohols / Q000737:chemistry*; D055162:Biocatalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones; D000429:Alcohol Oxidoreductases