title: Gold(I)-catalyzed intramolecular tandem addition/Friedel-Crafts reactions between acyclic enamides and 1-arylalkynes.
abstract: Electron-deficient acyclic enamine derivatives react with electron-rich 1-arylalkynes using cationic gold(I) species as catalysts in an intramolecular process to form annulated 1-amido-substituted indene derivatives as the major products. Yields for this process range between 21% and 98%. In some cases, a two-step process that includes a subsequent alkene isomerization is needed.
authors.affiliation: Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Kozak
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Dake