title: Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis.
  
  
  METHODS
  Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE, EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR) with 95% confidence interval (CI) was calculated.
  
  
  RESULTS
  Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C, -1195A, -1290G, *2430T alleles and *429TT genotype revealed increased risk for GC (OR = 1.71, 95% CI: 1.01-2.90, P = 0.05; OR = 1.58, 95% CI: 1.05-2.38, P = 0.03; OR = 1.55, 95% CI: 1.01-2.39, P = 0.05; OR = 2.62, 95% CI: 1.20-5.73, P = 0.02 and OR = 0.74, 95% CI: 0.59-0.95, P = 0.02, respectively).
  
  
  CONCLUSIONS
  The -765C, -1195A, -1290G, *2430T alleles and *429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC.
authors.affiliation: Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liang
authors.forename: Zhen-Ning
authors.initials: ZN
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Xing
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D051546:Cyclooxygenase 2