title: [Diagnostic value of reflux disease questionnaires in children with gastroesophageal reflux disease].
abstract: OBJECTIVE
  To evaluate the value of reflux diagnostic questionnaire in the diagnosis of children with gastroesophageal reflux disease (GERD).
  
  
  METHODS
  Forty-five children aged 7-16 years old referred for suspected GERD with vomiting/regurgitation, nausea, heartburn/retrosternal pain, abdominal pain, epigastric pain, acid regurgitation and pain while swallowing were assessed. Each symptom was rated from 0 to 3 according to its severity and frequency. The items of questionnaire were validated against the results from upper gastrointestinal endoscopy and esophageal 24 h pH monitoring. And the results were compared with symptom scores to determine the threshold value for GERD.
  
  
  RESULTS
  In 45 patients, the ratio of male to female was 1.37:1 and the mean age (11.1±2.6) years old. Composite score in 23 patients with GERD (20±10) was significantly higher than that in 22 patients without GERD (13±4) (P<0.05). There was no significant difference of composite scores among patients with grades 0, I, II and III according to upper gastrointestinal endoscopy (P>0.05). With 13.0 as threshold score for GERD, the sum of sensitivity and specificity was maximal. The area under the receiver operating characteristic curve (ROC) was 0.79 while true positive diagnostic rate 72.0% and true negative diagnostic rate 75.0% with a sensitivity of 78.3%, a specificity of 68.2% and an accuracy of 73.3%.
  
  
  CONCLUSIONS
  Reflux diagnostic questionnaire is a suitable method in initial diagnosis of GERD. It may serve as a screening test for GERD in 7-16-year-old children.
authors.affiliation: Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Zhao-lu
authors.initials: ZL
authors.lastname: Ding
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Wang
authors.forename: Wen-jing
authors.initials: WJ
authors.lastname: Ji
authors.forename: Xi-wei
authors.initials: XW
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires