title: Sympathoinhibition to Bezold-Jarisch reflex is attenuated in protein malnourished rats.
abstract: Malnutrition affects cardiovascular reflexes, including chemoreflex and baroreflex. In this study we assessed the hypothesis that malnourishment changes the responses in mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) evoked from Bezold-Jarisch reflex (BJR). Fischer rats were fed diets containing either (6% malnourished or 14% control) protein for 35 days after weaning. There were no differences in baseline MAP (102 ± 4 vs. 95 ± 3 mmHg) whereas higher baseline HR (478 ± 18 vs. 360 ± 11 bpm; P<0.05,) and reduced sympathoinhibition (ΔRSNA=-54 ± 9 vs. -84 ± 7%; P=0.0208) to BJR activation were found in malnourished rats. We conclude that malnutrition affects the sympathetic control of BJR.
authors.affiliation: Federal University of Bahia (UFBA), Campus Vitória da Conquista, BA, Brazil.
authors.forename: Vanessa Moraes
authors.initials: VM
authors.lastname: Bezerra
authors.forename: Carlos Henrique
authors.initials: CH
authors.lastname: Xavier
authors.forename: Luciano Gonçalves
authors.initials: LG
authors.lastname: Fernandes
authors.forename: Leonardo Máximo
authors.initials: LM
authors.lastname: Cardoso
authors.forename: Marco Antônio Peliky
authors.initials: MA
authors.lastname: Fontes
authors.forename: Deoclécio Alves
authors.initials: DA
authors.lastname: Chianca
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D008297:Male; D011488:Protein Deficiency / Q000503:physiopathology*; D051381:Rats; D011916:Rats, Inbred F344; D013564:Sympathetic Nervous System / Q000503:physiopathology*