title: Synthesis of seco-chlorinated derivatives of phenanthroindolizidine precursors via Friedel-Crafts reaction.
abstract: In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (4) and N-(4-chloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (5) were obtained. The structures of these compounds were determined by spectroscopic analysis.
authors.affiliation: Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: Yihan
authors.initials: Y
authors.lastname: Hu
authors.forename: Dan
authors.initials: D
authors.lastname: Zheng
authors.forename: Yingbo
authors.initials: Y
authors.lastname: Fu
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010618:Phenanthrolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007212:Indolizines; D010618:Phenanthrolines; C521640:phenanthroindolizidine