title: Multivitamin and micronutrient treatment improves semen parameters of azoospermic patients with maturation arrest.
abstract: The study was undertaken to evaluate the efficacy of multivitamin and micronutrient supplementation in azoospermic patients with maturation arrest. A total of 35 azoospermic patients showing maturation arrest on testicular biopsy were recruited in this study. The patients were divided into two groups. Untreated group (n=11) without any treatment and treated group (n=24) who received multivitamins, micronutrients and co-enzyme Q10. The sperm concentration, motility and morphology were evaluated at monthly interval. The results showed reduction in liquefaction time and relative viscosity of the semen in the treated group. Further, in treated group there was appearance of spermatozoa (4.0 million/ml) exhibiting progressive motility (7%) and normal morphology (6%), even in the first follow up visit. The sperm count, motility and normal morphology increased significantly on subsequent visits. Within 3 months (3 visits) 2 pregnancies were reported. These observations indicate that multivitamin and micronutrient supplementation improve the qualitative and quantitative parameters of seminogram in patients with azoospermia of maturation arrest.
authors.affiliation: Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Singh
authors.forename: Anil K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: Pratap B
authors.initials: PB
authors.lastname: Singh
authors.forename: Udai S
authors.initials: US
authors.lastname: Dwivedi
authors.forename: Sameer
authors.initials: S
authors.lastname: Trivedi
authors.forename: Surya K
authors.initials: SK
authors.lastname: Singh
authors.forename: Neeraj K
authors.initials: NK
authors.lastname: Agrawal
authors.forename: Shripad B
authors.initials: SB
authors.lastname: Deshpande
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000188:drug therapy* / Q000503:physiopathology; D001706:Biopsy; D019587:Dietary Supplements; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D018977:Micronutrients / Q000627:therapeutic use*; D011247:Pregnancy; D018873:Pregnancy Rate; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use; D014783:Viscosity; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D018977:Micronutrients; D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10