title: Seroconversion of acute hepatitis B by antiretroviral therapy in an HIV-1 infected patient.
abstract: A 33-year-old man with human immunodeficiency virus type1 (HIV-1) infection was admitted because of acute hepatitis B. His serum alanine aminotransferase level was 1200 IU/mL and CD4 cells count was 268/mm3. Antiretroviral therapy including tenofovir and emtricitabine, which suppresses both HIV and hepatitis B virus (HBV) replication, was initiated. The liver enzymes decreased dramatically. The viral loads of both HIV-1 and HBV were suppressed below detectable limits. Seroconversion from hepatitis B surface antigen to hepatitis B surface antibody was acquired 19 weeks later. In this case, the initiation of antiretroviral therapy with anti-HBV activity during the acute phase of hepatitis B had a favourable effect on HBV serostatus.
authors.affiliation: Division of Respiratory Medicine, National Hospital Organization, Higashi-Saitama Hospital, Japan.
authors.forename: Mahoko
authors.initials: M
authors.lastname: Ikeda-Kamimura
authors.forename: Masahide
authors.initials: M
authors.lastname: Horiba
mesh_terms: D000328:Adult; D015897:Comorbidity; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1; D006509:Hepatitis B / Q000188:drug therapy* / Q000453:epidemiology* / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000276:immunology; D006801:Humans; D008297:Male; D019562:Viral Load
chemical_list: D006513:Hepatitis B e Antigens