title: Synthesis of amino-1,2,4-triazoles by reductive ANRORC rearrangements of 1,2,4-oxadiazoles.
abstract: The reaction of various 1,2,4-oxadiazoles with an excess of hydrazine in DMF has been investigated. 3-Amino-1,2,4-triazoles are produced through a reductive ANRORC pathway consisting of the addition of hydrazine to the 1,2,4-oxadiazole followed by ring-opening, ring-closure, and final reduction of the 3-hydroxylamino-1,2,4-triazole intermediate. The general applicability of 1,2,4-oxadiazoles ANRORC reactivity is demonstrated also in the absence of C(5)-linked electron-withdrawing groups.
authors.affiliation: Dipartimento di Chimica Organica E. Paternò, Università degli Studi di Palermo, Viale delle Scienze - Parco d'Orleans II, I-90128 Palermo, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Palumbo Piccionello
authors.forename: Annalisa
authors.initials: A
authors.lastname: Guarcello
authors.forename: Silvestre
authors.initials: S
authors.lastname: Buscemi
authors.forename: Nicolò
authors.initials: N
authors.lastname: Vivona
authors.forename: Andrea
authors.initials: A
authors.lastname: Pace