title: Seeing is believing: how the MIP-luc mouse can advance the field of islet transplantation and β-cell regeneration.
abstract: In the last five years, bioluminescence has emerged as a vital tool in the non-invasive quantification of beta-cell mass following islet transplantation in murine models. The successes achieved in bioluminescence imaging in islet transplantation has prompted its use in the discipline of beta-cell regeneration. Employing bioluminescence permits quantifying changes in β-cell mass in an individual mouse over time, which can provide valuable insights into the kinetics of beta-cell regeneration.
authors.affiliation: Department of Surgery, University of Chicago, Chicago, IL, USA. eric.grossman@uchospitals.edu
authors.forename: Eric
authors.initials: E
authors.lastname: Grossman
authors.forename: Jing
authors.initials: J
authors.lastname: Tao
authors.forename: Raphael
authors.initials: R
authors.lastname: Wilson
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Graeme
authors.initials: G
authors.lastname: Bell
authors.forename: Anita
authors.initials: A
authors.lastname: Chong
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D004195:Disease Models, Animal; D017930:Genes, Reporter; D007328:Insulin / Q000235:genetics*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008156:Luciferases / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000502:physiology; D012038:Regeneration / Q000235:genetics / Q000502:physiology*
chemical_list: D007328:Insulin; D008156:Luciferases