title: AGE-RAGE in multiple sclerosis brain.
abstract: This pilot study used immunohistochemical techniques to investigate the advanced glycation end-product (AGE) Nepsilon-(carboxymethyl)lysine (CML) and its receptor (RAGE) in the brains of multiple sclerosis (MS) patients, comparing them with the brains of patients with Alzheimer's disease (AD) (positive controls) and with age-matched control subjects (negative controls). Postmortem slides derived from the hippocampi of MS patients, AD patients, and controls were stained with monoclonal antibodies for CML and human RAGE. Results showed increased AGE and RAGE immunostaining in the hippocampi of MS patients, similar to AD patients.
authors.affiliation: Department of Neurology, Jacobs Neurological Institute, Buffalo, New York 14223, USA. zs2@buffalo.edu
authors.forename: Zohara
authors.initials: Z
authors.lastname: Sternberg
authors.forename: Peter
authors.initials: P
authors.lastname: Ostrow
authors.forename: Mary
authors.initials: M
authors.lastname: Vaughan
authors.forename: Trevor
authors.initials: T
authors.lastname: Chichelli
authors.forename: Frederick
authors.initials: F
authors.lastname: Munschauer
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000276:immunology / Q000473:pathology; D001921:Brain / Q000276:immunology / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D010865:Pilot Projects; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; C048496:N(6)-carboxymethyllysine; D008239:Lysine