title: Spiral wave induced numerically using electrical stimulation and comparison with experimental results.
abstract: Experiments in vitro on a Microelectrode Array (MEA) platform show that electrical stimulation can provoke the generation of spiral waves in cardiac tissue. Nevertheless, the conditions leading to this artificial fibrillation state remain unclear. In order to have a better understanding of this phenomenon, a numerical simulation study has been conducted. The results obtained with a two-dimensional FitzHugh-Nagumo model proved that it is possible to create spiral waves by adding a stimulation current under certain conditions, which are made explicit.
authors.affiliation: Laboratoire LE2I UMR CNRS 5158, Université de Bourgogne, 9 avenue Alain Savary, BP47870, 21078 Dijon, France. stbin@u-bourgogne.fr
authors.forename: Binbin
authors.initials: B
authors.lastname: Xu
authors.forename: Sabir
authors.initials: S
authors.lastname: Jacquir
authors.forename: Gabriel
authors.initials: G
authors.lastname: Laurent
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Bilbault
authors.forename: Stéphane
authors.initials: S
authors.lastname: Binczak
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D000818:Animals; D000831:Animals, Newborn; D001145:Arrhythmias, Cardiac; D001698:Biomedical Engineering / Q000379:methods; D002478:Cells, Cultured; D003198:Computer Simulation; D004558:Electric Stimulation; D004566:Electrodes; D004594:Electrophysiology / Q000379:methods*; D006321:Heart; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009206:Myocardium / Q000166:cytology; D051381:Rats