title: Hooked on Hes: a T-ALL of addiction.
abstract: Hes1 is a direct Notch1 target; however, its precise function is unclear. In this issue of Immunity, Wendorff et al. (2010) report that Hes1 regulates the number of T cell progenitors and has important functions in both the induction and maintenance of T cell leukemia.
authors.affiliation: Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. wpear@mail.med.upenn.edu
authors.forename: Warren S
authors.initials: WS
authors.lastname: Pear