title: HLA-G in organ transplantation: towards clinical applications.
abstract: HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.
authors.affiliation: Etablissement Français du Sang, EA3855 Tours, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Deschaseaux
authors.forename: Diego
authors.initials: D
authors.lastname: Delgado
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
authors.forename: Massimo
authors.initials: M
authors.lastname: Giuliani
authors.forename: Fabio
authors.initials: F
authors.lastname: Morandi
authors.forename: Antoine
authors.initials: A
authors.lastname: Durrbach
mesh_terms: D005786:Gene Expression Regulation; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D016377:Organ Transplantation
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I