title: Modeling the effect of selected cyclodextrins on nifedipine solubility.
abstract: Nifedipine is a dihydropyridine calcium channel antagonist effective in the clinical management of cardiovascular disease. Due to nifedipine's poor water solubility and erratic bioavailability, complexation with selected cyclodextrins was studied in order to overcome these limitations. The aim was to develop a quantitative structure property relationship (QSPR) to identify cyclodextrin molecular properties important in complex formation and provide a predictive tool which would be valuable during preformulation studies. The QSPR developed indicates that the major driving forces for nifedipine complexation, in addition to cyclodextrin concentration, are hydrophobicity and Van der Waals interactions (3D solubility parameters, hydrophilic surface area and differential connectivity index).
authors.affiliation: The School of Pharmacy and Applied Science, La Trobe Institute of Molecular Sciences, La Trobe University, Bendigo, Victoria, Australia.
authors.forename: Snezana
authors.initials: S
authors.lastname: Agatonovic-Kustrin
authors.forename: David W
authors.initials: DW
authors.lastname: Morton
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Worthington
authors.forename: Beverley D
authors.initials: BD
authors.lastname: Glass
mesh_terms: D002121:Calcium Channel Blockers / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D015394:Molecular Structure; D009543:Nifedipine / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D002121:Calcium Channel Blockers; D003505:Cyclodextrins; D009543:Nifedipine