title: Biobehavioral influences on cancer progression.
abstract: This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.
authors.affiliation: Department of Psychiatry, Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA. ecostanzo@wisc.edu
authors.forename: Erin S
authors.initials: ES
authors.lastname: Costanzo
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
authors.forename: Susan K
authors.initials: SK
authors.lastname: Lutgendorf
mesh_terms: D003863:Depression; D018450:Disease Progression; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007165:Immunosuppression Therapy; D007249:Inflammation; D009369:Neoplasms / Q000276:immunology* / Q000523:psychology*; D018919:Neovascularization, Physiologic; D010913:Pituitary-Adrenal System / Q000502:physiology; D055500:Resilience, Psychological; D012944:Social Support; D013315:Stress, Psychological; D013564:Sympathetic Nervous System / Q000502:physiology