title: The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases.
abstract: Psychological stress has known effects on the immune system, including impacting effector and regulatory components. This can result in increased susceptibility to various infections, latent virus reactivation, and impact on immunoregulatory circuits. One of the great challenges in translational research is defining the risks associated with stress in specific patient populations and individuals. Future studies must include identification and validation of biomarkers that can categorize patient risk for adverse immune effects from various forms and degrees of psychological stress and how this impacts the course of their inflammatory disease.
authors.affiliation: Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, Department of Medicine, The University of Mississippi Medical Center, 2500 North State Street N416, Jackson, MS 39216-4505, USA. gmarshall@umc.edu
authors.forename: Gailen D
authors.initials: GD
authors.lastname: Marshall
mesh_terms: D001007:Anxiety; D016207:Cytokines / Q000378:metabolism; D003863:Depression; D004198:Disease Susceptibility; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007239:Infections / Q000276:immunology; D007249:Inflammation; D011598:Psychoneuroimmunology; D013315:Stress, Psychological; D014945:Wound Healing
chemical_list: D016207:Cytokines