title: [Fertilizing ability, cleavage potential and inheritance risk of globozoospermia].
abstract: OBJECTIVE
  To explore the fertilizing ability, cleavage potential and inheritance risks of globozoospermia.
  
  
  METHODS
  A globozoospermic patient was diagnosed by sperm morphological staining and transmission electron microscope. From his wife the investigators obtained 26 oocytes in which 6 oocytes were donated and the other 19 (in 20) MII oocytes injected into 19 round-headed sperms. Six donated oocytes accepted in vitro fertilization (IVF). This patient's chromosome and microdeletion in AZFa, AZFb and AZFc in Y chromosome were checked through 6 sequence tag sites of sY84, sY86, sY127, sY134, sY254 and sY255.
  
  
  RESULTS
  Only 4 (in 19) were normally fertilized and cleaved. All 6 donated oocytes were normally fertilized and cleaved. The fertilizing rate was significantly higher than that of this patient (100% vs 21.1%, P < 0.01). But the cleavage rate has no statistical difference (100% vs 100%, P > 0.05). This patient had normal chromosome (46, XY) and there was no deletion in Y chromosome. His wife became pregnant after accepting two thawed embryos and then gave birth to a boy whose chromosome was normal (46, XY). The acceptor also gave birth to a healthy boy after accepting two thawed embryos.
  
  
  CONCLUSIONS
  Despite a lower fertilizing rate, intracytoplasmic sperm injection is still an effective therapy for globozoospermic infertility.
authors.affiliation: Department of Obstetrics & Gynecology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Huang
authors.forename: Ling-ying
authors.initials: LY
authors.lastname: Jiang
authors.forename: Wei-hai
authors.initials: WH
authors.lastname: Xu
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Tong
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Zhu
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Liu
authors.initials: L
authors.lastname: Liu
authors.forename: Xiao-na
authors.initials: XN
authors.lastname: Lin
authors.forename: Song-ying
authors.initials: SY
authors.lastname: Zhang
mesh_terms: D000177:Acrosome; D000328:Adult; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000628:therapy; D008297:Male; D011247:Pregnancy; D013077:Sperm Head; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities* / Q000254:growth & development*