title: [Preparation and biocompatibility evaluation of osteochondral composite scaffold].
abstract: OBJECTIVE
  To prepare osteochondral composite scaffold and study its biocompatibility in vitro.
  
  
  METHODS
  The composite material of nano-HAP/collagen I was prepared, and the osteochondral scaffold was manufactured by combining nano-HAP, collagen I, and PLGA as the bone section and sodium hyaluronate and PLGA as the chondral section. The diameter, chemical composition and crystallinity of the nano-HAP/collagen I composite particles were assessed with TEM, FTIR and XRD, and the biocompatibility and cytotoxicity of the scaffold were evaluated using MTT assay by co-culturing bone marrow stem cells and the scaffold.
  
  
  CONCLUSIONS
  The osteochondral composite scaffold has good microstructure without obvious cytotoxicity, possesses good biocompatibility with bone marrow stem cells and is suitable as an osteochondral scaffold material.
authors.affiliation: Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China. wangqiul1985@163.com
authors.forename: Qiu-ling
authors.initials: QL
authors.lastname: Wang
authors.forename: De-ming
authors.initials: DM
authors.lastname: Xie
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Lv
mesh_terms: D001672:Biocompatible Materials; D001854:Bone Marrow Cells / Q000166:cytology; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology; D017886:Durapatite; D006801:Humans; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite