title: Multiscale imaging of the human heart: Building the foundation for human systems physiology and translational medicine.
abstract: The development of human cardiovascular systems physiology is inhibited by the lack of multiscale functional physiological data, which represents human heart physiology at the molecular, cellular, tissue, organ, and system levels. We have developed an experimental approach to study explanted human hearts in vitro at multiple physiological scales with a wide array of imaging modalities. This approach has already yielded data indicating significant differences between animal models of diseases and actual human heart disease. Our data provides a quantitative foundation for multiscale physiological models of the cardiovascular system and will allow improvement in translation of medical technology and pharmacology from animal models to therapy.
authors.affiliation: Department of Biomedical Engineering, Washington University in St. Louis, MO 63130, USA. igor@wustl.edu
authors.forename: Igor R
authors.initials: IR
authors.lastname: Efimov
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Fedorov
authors.forename: Alexey
authors.initials: A
authors.lastname: Glukhov
authors.forename: Qing
authors.initials: Q
authors.lastname: Lou
authors.forename: Christina
authors.initials: C
authors.lastname: Ambrosi
authors.forename: Deborah
authors.initials: D
authors.lastname: Janks
authors.forename: William J
authors.initials: WJ
authors.lastname: Hucker
authors.forename: Thomas
authors.initials: T
authors.lastname: Kurian
authors.forename: Richard B
authors.initials: RB
authors.lastname: Schuessler
authors.forename: Nader
authors.initials: N
authors.lastname: Moazami
mesh_terms: D002118:Calcium / Q000378:metabolism; D002320:Cardiovascular Physiological Phenomena; D056966:Excitation Contraction Coupling; D005260:Female; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology*; D016027:Heart Transplantation / Q000706:statistics & numerical data; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008564:Membrane Potentials; D057170:Translational Research, Biomedical
chemical_list: D002118:Calcium