title: SUMOylation in ocular development and pathology.
abstract: SUMOylation, a posttranslational modification process in which SUMO, the small ubiquitin-related modifier or small ubiquitin-like modifier, is added to the target proteins, plays an important role in regulating a variety of cellular processes including protein-protein interactions, subcellular localization, protein-DNA interactions and enzyme activity. This process adds another layer of control in eukaryote gene expression, and it regulates both transcriptional activation and repression. In the present review, we summarized the currently emerging information regarding the function of SUMOylation in ocular development and pathology.
authors.affiliation: Department of Biochemistry & Molecular Biology, College of Medicine, 985870 Nebraska Medical Center, Omaha, NE 68198-5870, USA.
authors.forename: L
authors.initials: L
authors.lastname: Gong
authors.forename: D W-C
authors.initials: DW
authors.lastname: Li
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005123:Eye / Q000196:embryology* / Q000503:physiopathology*; D005136:Eye Proteins / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D017948:Retinal Rod Photoreceptor Cells / Q000166:cytology / Q000378:metabolism; D025842:SUMO-1 Protein / Q000378:metabolism; D058207:Sumoylation / Q000502:physiology*
chemical_list: D005136:Eye Proteins; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D025842:SUMO-1 Protein; C119380:lens epithelium-derived growth factor