title: Medical and surgical therapy for advanced chronic venous insufficiency.
abstract: Venous ulceration is the most serious consequence of chronic venous insufficiency. The disease has been known for more than 3.5 millennia with wound care centers established as early as 1500 bc. Unfortunately, still today it is a very poorly managed medical condition by most physicians despite that a great deal has been learned about the pathogenesis and treatment for venous ulcerations. We find that many wound care clinics treat the wound and not the cause of the problem. In this article, we review the basic pathophysiology of advanced chronic venous insufficiency and review the most up-to-date information with regard to medical therapy and different options of surgical therapy to address the underlying venous pathology responsible for chronic ulcers.
authors.affiliation: Department of Surgery, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA. Word.ronnie@marshfieldclinic.org
authors.forename: Ronnie
authors.initials: R
authors.lastname: Word
mesh_terms: D001458:Bandages; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D008297:Male; D010431:Pentoxifylline / Q000627:therapeutic use; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016038:Skin Transplantation / Q000379:methods*; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D014689:Venous Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology
chemical_list: D010431:Pentoxifylline