title: New insights in the management of antipsychotics in the treatment of schizophrenia in a patient with prolactinoma: a case report and review of the literature.
abstract: Prolactinomas are the commonest pituitary adenomas and the major pathological cause of hyperprolactinaemia. Symptomatic prolactinomas are treated mainly by dopamine agonists; surgery and radiotherapy are options for nonresponders. Schizophrenia treatment is based on antipsychotics, which acts mainly at serotonergic and dopaminergic systems. We report a case of a 39-year-old schizophrenic male patient that was diagnosed with a macroprolactinoma 8 years after his first psychotic episode. The association of Schizophrenia and prolactinoma represents a clinical challenge once the treatment of one disease can exacerbate the symptoms of the other.
authors.affiliation: Psychiatry Department, Federal University of São Paulo (UNIFESP), 04023-900 São Paulo, Brazil.
authors.forename: Elvis Henrique
authors.initials: EH
authors.lastname: Santos Andrade
authors.forename: Pedro Mario
authors.initials: PM
authors.lastname: Pan
authors.forename: Paula F Ramalho
authors.initials: PF
authors.lastname: da Silva
authors.forename: Ary
authors.initials: A
authors.lastname: Gadelha