title: PhysioDoloris: a monitoring device for analgesia / nociception balance evaluation using heart rate variability analysis.
abstract: Continuous Analgesia / Nociception balance evaluation during general anesthesia could be of precious help for the optimization of analgesic drugs delivery, limiting the risk of toxicity due to the use of opioid drugs, limiting the risk of post operative hyper algesia, and, probably, reducing time of recovery after surgical procedure. Heart Rate Variability analysis has been shown in several studies to measure the Autonomic Nervous System tone, which is strongly influenced by anesthetic drugs. Recording RR series during general anesthesia enabled us to observe that the Respiratory Sinus Arrhythmia pattern changed when a surgical stimulation was painful, even though the patient was not conscious. We have previously developed and evaluated a pain / analgesia measurement algorithm based on the magnitude analysis of the respiratory patterns on the RR series. In this paper, we present the development of a monitoring device (PhysioDoloris), based on the previously described technology, giving in real time an Analgesia Nociception Index (ANI) which can be used during general anesthesia in order to give to the anesthetist, a complementary tool for optimized drug delivery.
authors.affiliation: INSERM CIC-IT 807, University Hospital of Lille, Institut Hippocrate, 2 avenue Oscar Lambret 59037 Lille Cedex, France. rlogier@chru-lille.fr
authors.forename: R
authors.initials: R
authors.lastname: Logier
authors.forename: M
authors.initials: M
authors.lastname: Jeanne
authors.forename: J
authors.initials: J
authors.lastname: De Jonckheere
authors.forename: A
authors.initials: A
authors.lastname: Dassonneville
authors.forename: M
authors.initials: M
authors.lastname: Delecroix
authors.forename: B
authors.initials: B
authors.lastname: Tavernier
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D010147:Pain Measurement / Q000187:drug effects*; D010149:Postoperative Pain / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics