title: Cytotoxic triterpenoids from Maytenus retusa.
abstract: Seven new triterpenoids (1-7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures were determined by 1D and 2D spectroscopic studies. Several compounds were evaluated for their cytotoxicity against the human tumor cell lines HL-60 and MCF-7. Some of them were cytotoxic, with IC(50) values ranging between 0.2 and 4.7 μM.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Avenida Astrofísico Francisco Sánchez 2, La Laguna, Tenerife, Spain.
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Oramas-Royo
authors.forename: Haydee
authors.initials: H
authors.lastname: Chávez
authors.forename: Patricia
authors.initials: P
authors.lastname: Martín-Rodíguez
authors.forename: Leandro
authors.initials: L
authors.lastname: Fernández-Pérez
authors.forename: Angel G
authors.initials: AG
authors.lastname: Ravelo
authors.forename: Ana
authors.initials: A
authors.lastname: Estévez-Braun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D029755:Maytenus / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes