title: A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese.
abstract: BACKGROUND
  Adrenomedullin, a vasodilatory peptide, facilitates the differentiation of pre-adipocytes, and affects lipolysis and glucose uptake. We investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding adrenomedullin (ADM) with dysglycemia in the Hong Kong Chinese population.
  
  
  METHODS
  Four SNPs were genotyped in 1391 subjects without dysglycemia at baseline from the Hong Kong Cardiovascular Risk Factor Prevalence Study-2, which had a median follow-up time of 6.4 years. Dysglycemia included impaired fasting glucose, impaired glucose tolerance, and diabetes according to the WHO 1998 criteria. At follow-up, 382 subjects had developed dysglycemia.
  
  
  RESULTS
  In stepwise logistic regression, the SNP rs11042725 was a significant independent predictor of the development of dysglycemia (OR=1.31, P=0.012), together with baseline age (P<0.001), plasma triglycerides (P<0.001), body mass index (P=0.004), 2-h glucose after oral glucose tolerance test (P<0.001), homeostasis model assessment of insulin resistance index (P=0.045), and follow-up duration (P=0.009). The association was more significant in women (P=0.002) and in subjects without regular exercise (P=0.001).
  
  
  CONCLUSIONS
  Our study suggests a potential role of genetic variants in the ADM gene in the development of dysglycemia in our local Chinese population.
authors.affiliation: Department of Medicine, University of Hong Kong, Hong Kong.
authors.forename: Kwok Leung
authors.initials: KL
authors.lastname: Ong
authors.forename: Annette W K
authors.initials: AW
authors.lastname: Tso
authors.forename: Raymond Y H
authors.initials: RY
authors.lastname: Leung
authors.forename: Stacey S
authors.initials: SS
authors.lastname: Cherny
authors.forename: Pak Chung
authors.initials: PC
authors.lastname: Sham
authors.forename: Tai Hing
authors.initials: TH
authors.lastname: Lam
authors.forename: Bernard M Y
authors.initials: BM
authors.lastname: Cheung
authors.forename: Karen S L
authors.initials: KS
authors.lastname: Lam
mesh_terms: D053607:Adrenomedullin / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure; D002681:China / Q000208:ethnology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005838:Genotype; D044882:Glucose Metabolism Disorders / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D053607:Adrenomedullin