title: TGF-β signaling is altered in the peripheral blood of subjects with multiple sclerosis.
abstract: Multiple sclerosis (MS) is a central nervous system inflammatory disorder with evidence of peripheral immune dysregulation. Abnormalities of the immune suppressive cytokine TGF-β have been reported, but not fully defined, in MS. Through a pathway-focused expression profiling of the peripheral blood, we found abnormalities of TGF-βRII, SMAD4 and SMAD7 expression in subjects with MS, and reduction in the levels of TGF-β regulated genes, indicating an overall reduction in TGF-β signaling in MS. The response to exogenous TGF-β was intact, however, indicating an extrinsic defect of TGF-β signaling in MS. These results indicate that TGF-β control is diminished in MS.
authors.affiliation: Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Elise M
authors.initials: EM
authors.lastname: Meoli
authors.forename: Unsong
authors.initials: U
authors.lastname: Oh
authors.forename: Christian W
authors.initials: CW
authors.lastname: Grant
authors.forename: Steven
authors.initials: S
authors.lastname: Jacobson
mesh_terms: D000328:Adult; D015153:Blotting, Western; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000235:genetics / Q000276:immunology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D051906:Smad7 Protein / Q000097:blood / Q000235:genetics / Q000276:immunology; D014158:Transcription, Genetic; D053773:Transforming Growth Factor beta1 / Q000097:blood* / Q000235:genetics
chemical_list: C497806:SMAD7 protein, human; D051906:Smad7 Protein; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1