title: High frequency of low-risk human leukocyte antigen class II genotypes in latent celiac disease.
abstract: Human leukocyte antigen (HLA) class II genotypes in latent celiac disease, a clinical variant of celiac disease (CD) have been scarcely studied. The aim of this work was to investigate whether latent CD and CD share similar frequencies of HLA class II genotypes. HLA class II genotypes of CD patients compared with controls were subdivided in the following at-risk groups: DQB1*02/DQB1*02 (43.0%, odds ratio [OR] 8.02, p < 0.0001), DQB1*0302/DQB1*02 (12.2%, OR 2.77, p = 0.0002), DQB1*02/DQB1*X (39.2%, OR 1.23, p = 0.1903), DQB1*0302/DQB1*X (3.4%, OR 0.35, p = 0.0064) and DQB1*X/DQB1*X (0.8%, OR 0.01, p = 0.0001) where X is neither DQB1*0302 nor DQB1*02. Next, HLA class II genotypes of 21 latent CD patients were compared with the above at-risk groups. Only one latent CD patient (4.8%) was found in the high risk DQB1*02/DQB1*02 group, three (14.3%) were DQB1*0302/DQB1*02, one (4.8%) was DQB1*0302/DQB1*X and the remaining 16 (76.2%) showed the DQB1*02/DQB1*X genotype. Noteworthy, the only 1 patient with the DQB1*02/DQB1*02 high risk genotype did not carry the DR3-DQB1*02/DR3-DQB1*02 or the DR3-DQB1*02/DR7-DQB1*02 but the uncommon DR3-DQB1*02/DR4-DQB1*02 genotype. These data suggest that latent CD is prevalently associated with low-risk HLA class II genotypes.
authors.affiliation: Department of Pediatric Science and Clinical Medicine, University of Cagliari, Cagliari, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Schirru
authors.forename: Rita-Désirée
authors.initials: RD
authors.lastname: Jores
authors.forename: Lucia
authors.initials: L
authors.lastname: Cicotto
authors.forename: Fulvia
authors.initials: F
authors.lastname: Frau
authors.forename: Stefano
authors.initials: S
authors.lastname: De Virgiliis
authors.forename: Rossano
authors.initials: R
authors.lastname: Rossino
authors.forename: Maria Doloretta
authors.initials: MD
authors.lastname: Macis
authors.forename: Rosanna
authors.initials: R
authors.lastname: Lampis
authors.forename: Mauro
authors.initials: M
authors.lastname: Congia
mesh_terms: D000483:Alleles; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D002648:Child; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000706:statistics & numerical data; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology*; D006239:Haplotypes / Q000276:immunology*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012306:Risk; D012720:Severity of Illness Index
chemical_list: D006683:HLA-DQ Antigens