title: Evaluating antimicrobial efficacy and cost of 3 dressings containing silver versus a novel antimicrobial hydrogel impregnated gauze dressing containing Oakin, an oak extract.
abstract: OBJECTIVE
  Antimicrobial wound dressings are becoming more popular and are routinely used in the treatment of chronic and problematic wounds. Despite the ever-growing number and types of these antimicrobial products, many practitioners often do not report significant clinical differences between various common antimicrobial wound dressings despite wide variations in cost. Although these dressings use different active ingredients or different presentations of a particular active ingredient, all attempt to protect the wound from bacterial colonization and promote wound repair. With so many topical antimicrobial dressings to choose from in the clinical setting (many having already fallen into disfavor due to their cytotoxic characteristics) it was of prime interest to determine if there was a substantial difference between some of the more commonly used antimicrobial dressings, with silver versus an antimicrobial wound dressing using Oakin (oak extract [Amerx Health Care Corporation, Clearwater, Florida]) as the active ingredient.
  
  
  METHODS
  This article compares the antimicrobial efficacy of 4 commonly used wound dressings in vitro, utilizing a corrected zone of inhibition test followed by a cost analysis.
  
  
  RESULTS
  In vitro testing demonstrated that there were no substantial differences in the corrected zone of inhibition measurements between the silver wound dressings and the less expensive Oakin-impregnated gauze dressing.
  
  
  CONCLUSIONS
  Despite obvious limitations of this study, these results suggest that the biggest differences between many antimicrobial dressings on the market may be more in cost than in antimicrobial efficacy. The differences in cost are due to variances in cost per application and frequency of applications per week.
authors.affiliation: Cumberland Foot Health Solutions, Somerset, Kentucky, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Moore
authors.forename: Alvin
authors.initials: A
authors.lastname: Perkins
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D047070:Bandages, Hydrocolloid; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000627:therapeutic use; D007629:Kentucky; D045726:Metalloproteases / Q000187:drug effects; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D029963:Quercus; D018030:Silver Compounds / Q000191:economics / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000191:economics / Q000628:therapy
chemical_list: D000890:Anti-Infective Agents; D020100:Hydrogels; D010936:Plant Extracts; D018030:Silver Compounds; D045726:Metalloproteases