title: Changes of hippocampal CA3-CA1 population nonlinear dynamics across different training sessions in rats performing a memory-dependent task.
abstract: Delayed-nonmatch-to-sample (DNMS) task is memory-dependent. Hippocampal CA3 and CA1 cells were shown to be encoding the required spatial and temporal information to complete this task. In order to identify possible changes in neural population nonlinear dynamics during learning of the DNMS task, we have first modeled the input-output transformation of spike trains across brain subregions from learning animals using a multiple-input, multiple-output (MIMO) nonlinear dynamic model. The feedforward and feedback kernels describing the relations between hippocampal CA3 and CA1 subregions have shown significant changes at different training sessions.
authors.affiliation: Center for Neural Engineering, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. homchan@usc.edu
authors.forename: Rosa H M
authors.initials: RH
authors.lastname: Chan
authors.forename: Dong
authors.initials: D
authors.lastname: Song
authors.forename: Anushka V
authors.initials: AV
authors.lastname: Goonawardena
authors.forename: Sarah
authors.initials: S
authors.lastname: Bough
authors.forename: John
authors.initials: J
authors.lastname: Sesay
authors.forename: Robert E
authors.initials: RE
authors.lastname: Hampson
authors.forename: Sam A
authors.initials: SA
authors.lastname: Deadwyler
authors.forename: Theodore W
authors.initials: TW
authors.lastname: Berger
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D056654:CA3 Region, Hippocampal / Q000502:physiology*; D056228:Feedback, Sensory; D008297:Male; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D017711:Nonlinear Dynamics; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time; D013647:Task Performance and Analysis