title: Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.
abstract: The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
authors.affiliation: School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Robert B P
authors.initials: RB
authors.lastname: Elmes
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Erby
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Cloonan
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Quinn
authors.forename: D Clive
authors.initials: DC
authors.lastname: Williams
authors.forename: Thorfinnur
authors.initials: T
authors.lastname: Gunnlaugsson
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity; D004247:DNA / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008027:Light
chemical_list: D056831:Coordination Complexes; D004247:DNA