title: [Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].
abstract: Breast cancer is the most incident cancer among women. We investigated the role of polymorphisms of folate metabolizing genes MTHFR (C677T and A1298C), SHMT1 (C1420T) and MTHFD (G1258A) in genetic susceptibility to this type of cancer. We determined allele and genotype frequencies in case (850 women with sporadic form of breast cancer) and control (810 women) groups. None of these polymorphisms was significantly associated with breast cancer risk. To increase statistical power of our study, we conducted a meta-analysis which included published genotype data and the results of our work. Meta-analysis also revealed no significant association of studied SNPs with breast cancer.
authors.forename: A S
authors.initials: AS
authors.lastname: Vaĭner
authors.forename: U A
authors.initials: UA
authors.lastname: Boiarskikh
authors.forename: E N
authors.initials: EN
authors.lastname: Voronina
authors.forename: I A
authors.initials: IA
authors.lastname: Selezneva
authors.forename: T V
authors.initials: TV
authors.lastname: Sinkina
authors.forename: A F
authors.initials: AF
authors.lastname: Lazarev
authors.forename: V D
authors.initials: VD
authors.lastname: Petrova
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005492:Folic Acid / Q000235:genetics / Q000378:metabolism; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D012696:Glycine Hydroxymethyltransferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D020641:Polymorphism, Single Nucleotide; D012800:Siberia / Q000453:epidemiology
chemical_list: D015778:Minor Histocompatibility Antigens; D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C539735:MTHFD1 protein, human; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D012696:Glycine Hydroxymethyltransferase; C520541:SHMT protein, human