title: Effects of tamoxifen on tissue nitrite/nitrate levels and plasma lipid peroxidation in female rats.
abstract: OBJECTIVE
  The effects of tamoxifen on lipid peroxidation and oxidant-antioxidant balance in an animal model were studied.
  
  
  METHODS
  Twelve female adult rats were divided into two groups and DMSO and tamoxifen dissolved in DMSO were administered. Tissues taken from the brain, liver and ovary of rats were dissected. MDA, nitrite, nitrate levels and plasma LDL oxidation in brain, ovary and liver tissues were measured and compared.
  
  
  RESULTS
  Induced LDL MDA levels were significantly lower in the tamoxifen group (p = 0.009). MDA levels in the liver were significantly lower in the tamoxifen group whereas nitrite levels were found significantly higher (p < 0.05). Brain and ovarian tissues demonstrated no significant difference with respect to MDA, nitrite and nitrate levels.
  
  
  CONCLUSIONS
  Tamoxifen has no negative effects on lipid peroxidation in an animal model.
authors.affiliation: Department of Obstetrics and Gynecology, Ege University School of Medicine, Bornova, Izmir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Gharehbagni
authors.forename: F
authors.initials: F
authors.lastname: Sendag
authors.forename: F
authors.initials: F
authors.lastname: Akercan
authors.forename: B
authors.initials: B
authors.lastname: Zeybek
authors.forename: E
authors.initials: E
authors.lastname: Sezer
authors.forename: M C
authors.initials: MC
authors.lastname: Terek
authors.forename: N
authors.initials: N
authors.lastname: Karadadas
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D009566:Nitrates / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism; D051381:Rats; D013629:Tamoxifen / Q000494:pharmacology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008077:Lipoproteins, LDL; D009566:Nitrates; D009573:Nitrites; D013629:Tamoxifen