title: Viral sequence analysis from HIV-infected mothers and infants: molecular evolution, diversity, and risk factors for mother-to-child transmission.
abstract: Great progress has been made in understanding the pathogenesis, treatment, and transmission of HIV and the factors influencing the risk of mother-to-child transmission (MTCT). Many questions regarding the molecular evolution and genetic diversity of HIV in the context of MTCT remain unanswered. Further research to identify the selective factors governing which variants are transmitted, how the compartmentalization of HIV in different cells and tissues contributes to transmission, and the influence of host immunity, viral diversity, and recombination on MTCT may provide insight into new prevention strategies and the development of an effective HIV vaccine.
authors.affiliation: Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305-4200, USA.
authors.forename: Philip L
authors.initials: PL
authors.lastname: Bulterys
authors.forename: Sudeb C
authors.initials: SC
authors.lastname: Dalai
authors.forename: David A
authors.initials: DA
authors.lastname: Katzenstein
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000627:therapeutic use; D015195:Drug Design; D024882:Drug Resistance, Viral; D019143:Evolution, Molecular; D005260:Female; D014644:Genetic Variation; D006678:HIV / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission* / Q000821:virology*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011995:Recombination, Genetic; D012307:Risk Factors
chemical_list: D044966:Anti-Retroviral Agents; D019496:Cancer Vaccines