title: Essential oil of Thymus capitatus Hoff. et Link. from Matmata, Tunisia: gas chromatography-mass spectrometry analysis and antimicrobial and antioxidant activities.
abstract: Thymus capitatus Hoff. et Link. essential oil was constituted by thymol (89.06%) as a major component followed by p-cimene (5.04%) and γ-terpinene (3.19%) after analysis by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. The antioxidant activity assays of the essential oil used in the inhibition of the radical cation 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) and the free radical 2,2-diphenyl-1-picrylhydrazyl showed high 50% inhibitory concentration values of 1.24 ± 0.05 mg/L and 0.59 ± 0.02 mg/L, respectively. The essential oil of T. capitatus was tested for antimicrobial activity against Gram-positive bacteria (Salmonella analum, Listeria monocytogenes), Gram-negative bacteria (Escherchia coli, Klebsiella pneumoniae), fungi (Mucor ramamnianus, Aspergillus ochraceus), and yeast species (Saccharomyces cerevisiae, Candida albicans) using the agar well diffusion method. It seemed that L. monocytogenes, E. coli, and K. pneumoniae bacteria were inhibited by the essential oil tested. A strong activity was also observed against fungi and yeasts.
authors.affiliation: Laboratoire de Modélisation Analyse et Commande des Systèmes, Ecole Nationale d'Ingénieurs de Gabès, Gabès, Tunisie. mounira.mkaddem@laposte.net
authors.forename: Mounira Guedri
authors.initials: MG
authors.lastname: Mkaddem
authors.forename: Mehrez
authors.initials: M
authors.lastname: Romdhane
authors.forename: Hany
authors.initials: H
authors.lastname: Ibrahim
authors.forename: Monia
authors.initials: M
authors.lastname: Ennajar
authors.forename: Ahmed
authors.initials: A
authors.lastname: Lebrihi
authors.forename: Florence
authors.initials: F
authors.lastname: Mathieu
authors.forename: Jalloul
authors.initials: J
authors.lastname: Bouajila
mesh_terms: D000465:Algorithms; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D052978:Disk Diffusion Antimicrobial Tests; D055808:Drug Discovery; D005520:Food Preservatives / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D039821:Monoterpenes / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D009994:Osmolar Concentration; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D053719:Tandem Mass Spectrometry; D013943:Thymol / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D046930:Thymus Plant / Q000737:chemistry*; D014416:Tunisia; D015003:Yeasts / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D005520:Food Preservatives; D016166:Free Radical Scavengers; D039821:Monoterpenes; D009822:Oils, Volatile; C007210:4-cymene; D013943:Thymol; C018669:gamma-terpinene