title: Solid core column technology applied to HPLC-FD of paralytic shellfish toxins.
abstract: Pre-column oxidation liquid chromatography with fluorescence detection is a chemical method for analyzing paralytic shellfish toxins. In order to improve the sample throughput and efficiency of AOAC Method 2005.06, solid core particle column technology was evaluated. We demonstrate that supplanting the original fully porous particle column with a solid core particle column reduces sample analysis time from 15 to 5 min per sample and improves resolution.
authors.affiliation: US FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, Spectroscopy and Mass Spectrometry Branch, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA. Stacey.DeGrasse@fda.hhs.gov
authors.forename: Stacey L
authors.initials: SL
authors.lastname: DeGrasse
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: DeGrasse
authors.forename: Kevin
authors.initials: K
authors.lastname: Reuter
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005506:Food Contamination / Q000032:analysis*; D057097:Harmful Algal Bloom; D057166:High-Throughput Screening Assays; D008387:Marine Toxins / Q000032:analysis*; D010839:Phytoplankton; D012758:Shellfish / Q000032:analysis*; D057096:Shellfish Poisoning; D052616:Solid Phase Extraction / Q000379:methods
chemical_list: D008387:Marine Toxins