title: [Association of aldosterone synthase (CYP11B2) gene -344T/C polymorphism with essential hypertension in Mongolian nationality].
abstract: OBJECTIVE
  To explore the relationship between the -344T/C polymorphism of aldosterone synthase (CYP11B2) gene and essential hypertension in Chinese Mongolian population.
  
  
  METHODS
  By cluster-sampling method, a total of 1575 Mongolian people in Tongliao city of Inner Mongolia were included in this study. And 417 subjects were normotension, 596 subjects were prehypertension and 562 subjects were essential hypertension. A survey was conducted to collect data by personal interview using a standard questionnaire, meanwhile fasting blood samples were drawn. Height, weight, waist circumference, blood pressure, blood-fat indexes and fasting plasma glucose were measured. The variant genotypes of CYP11B2 were identified by PCR assays. The relationship between the -344T/C polymorphism of CYP11B2 gene and essential hypertension were analyzed by multinomial logistic regression model.
  
  
  RESULTS
  Crude prevalence of prehypertension among Mongolian people was 37.84% (596/1575) and hypertension was 35.68% (562/1575). The age-standardized prevalence of prehypertension was 38.57% and hypertension was 31.53%. The frequency of the T and C allele was 0.66 (481/728) and 0.34 (247/728) for normotension group, 0.69 (696/1042) and 0.33 (346/1042) for prehypertension group, 0.71 (706/998) and 0.29 (292/998) for hypertension group. The multiple logistic models showed CYP11B2 variant genotypes were associated with prehypertension (TT/CC, OR = 1.33, 95%CI: 0.87 - 2.01; TC/CC, OR = 1.74, 95%CI: 1.13 - 2.67; TC + TT/CC, OR = 1.49, 95%CI: 1.01 - 2.22); CYP11B2 variant genotypes were associated with hypertension (TT/CC, OR = 1.70, 95%CI: 1.07 - 2.70; TC/CC, OR = 1.59, 95%CI: 0.98 - 2.50; TC + TT/CC, OR = 1.66, 95%CI: 1.06 - 2.58).
  
  
  CONCLUSIONS
  CYP11B2 gene -344T/C polymorphism were associated with essential hypertension in Chinese Mongolian population.
authors.affiliation: Department of Epidemiology, Soochow University, Suzhou 215123, China.
authors.forename: Xing-qiang
authors.initials: XQ
authors.lastname: Pan
authors.forename: Yong-yue
authors.initials: YY
authors.lastname: Liu
authors.forename: Ling-fei
authors.initials: LF
authors.lastname: Wang
authors.forename: Yao-jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Yong-hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Chang-chun
authors.initials: CC
authors.lastname: Qiu
authors.forename: Wei-jun
authors.initials: WJ
authors.lastname: Tong
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics*; D002681:China / Q000453:epidemiology; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D019405:Cytochrome P-450 CYP11B2