title: Stability of small mesoporous silica nanoparticles in biological media.
abstract: In this work, sub-50 nm pegylated mesoporous silica nanoparticles prepared with hydrothermal treatment are shown to have long-term stability in various media at both room and physiological temperature. Compared to bare mesoporous silica nanoparticles, the highly pegylated mesoporous silica nanoparticles show significantly improved biocompatibility and decreased macrophage uptake, making these nanoparticles viable for in vivo stealth drug delivery applications.
authors.affiliation: Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.
authors.forename: Yu-Shen
authors.initials: YS
authors.lastname: Lin
authors.forename: Nardine
authors.initials: N
authors.lastname: Abadeer
authors.forename: Christy L
authors.initials: CL
authors.lastname: Haynes
mesh_terms: D002021:Buffers; D003470:Culture Media / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: D002021:Buffers; D003470:Culture Media; D010710:Phosphates; D012822:Silicon Dioxide