title: Latent celiac disease in reproductive performance of women.
abstract: OBJECTIVE
  To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance.
  
  
  METHODS
  Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery.
  
  
  METHODS
  Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi.
  
  
  METHODS
  Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases).
  
  
  METHODS
  None.
  
  
  METHODS
  The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy.
  
  
  RESULTS
  The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects.
  
  
  CONCLUSIONS
  Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.
authors.affiliation: Department of Obstetrics and Gynecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India. ashkumar@eth.net
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Mamta
authors.initials: M
authors.lastname: Meena
authors.forename: Nargis
authors.initials: N
authors.lastname: Begum
authors.forename: Nirmal
authors.initials: N
authors.lastname: Kumar
authors.forename: Ram Kumar
authors.initials: RK
authors.lastname: Gupta
authors.forename: Sarita
authors.initials: S
authors.lastname: Aggarwal
authors.forename: Sudha
authors.initials: S
authors.lastname: Prasad
authors.forename: Swaraj
authors.initials: S
authors.lastname: Batra
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology* / Q000276:immunology; D000328:Adult; D058070:Asymptomatic Diseases / Q000453:epidemiology*; D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000453:epidemiology* / Q000276:immunology; D002585:Cesarean Section / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007194:India / Q000453:epidemiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D011503:Transglutaminases / Q000276:immunology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011503:Transglutaminases