title: Synthesis of a Tricyclic Core of Rameswaralide.
abstract: A tricyclic core containing a 5,7-fused bicyclic unit of rameswaralide was prepared starting from a 1,6-enyne. The synthetic sequence involved (i) ruthenium-catalyzed [5+2]-cycloaddition of 1,6-enyne, (ii) an acyl radical based approach to construct the lactone, and (iii) a regioselective installation of the conjugated double bond by a concomitant sulfenylation-dehydrosulfenylation sequence.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Hien M
authors.initials: HM
authors.lastname: Nguyen
authors.forename: Christopher
authors.initials: C
authors.lastname: Koradin