title: Novel influenza A (H1N1) in patients with hematologic disease.
abstract: Patients with hematologic disease are likely to be at increased risk for infection with influenza. We retrospectively analyzed 11 cases of patients with hematologic disease who were infected with pandemic H1N1 virus in our department, including their clinical manifestations, laboratory and imaging findings, outcomes of antiviral therapy, and factors associated with mortality. Notably, nine patients had lower respiratory tract disease. Five patients progressed to respiratory failure and eventually died, despite treatment with antivirals and/or corticosteroids and/or mechanical ventilation. We concluded that H1N1 2009 infection was associated with a severe course and high rate of mortality in patients with hematologic disease, and early diagnosis and antiviral treatment were important to reduce the rate of severe complications and mortality.
authors.affiliation: Department of Hematology, Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Ju-ying
authors.initials: JY
authors.lastname: Wei
authors.forename: Fei-fei
authors.initials: FF
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
authors.forename: Wen-yuan
authors.initials: WY
authors.lastname: Mai
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Qian
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Meng
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Mao
authors.forename: Gai-xiang
authors.initials: GX
authors.lastname: Xu
authors.forename: Hua-feng
authors.initials: HF
authors.lastname: Wang
authors.forename: Yin-jun
authors.initials: YJ
authors.lastname: Lou
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Tong
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006402:Hematologic Diseases / Q000150:complications* / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology; D007251:Influenza, Human / Q000150:complications* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents