title: [Nutrition and age-related macular degeneration].
abstract: Age-related macular degeneration is a growing burden disease with a high prevalence in elderly: it is the first cause of blindness in developped countries. It is a multifactorial disease with genetic factors and nutritional factors. Carotenoids, lutein and zeaxanthin are components of macular pigment and they have a filter role for blue light and an antioxidant role. Other nutritional factors might play a role as antioxidants: zinc, selenium, vitamin E, vitamin C… which lead to the ARED Study. It is the only one study with proven positive effects on the disease progression (stages 3 and 4). A high glycemic index increases oxidative stress. Long chain omega-3 polyunsaturated fatty acids have a protective effect. Available data are presented and discussed. These are new preventive issues.
authors.affiliation: Service de nutrition, institut Pasteur de Lille, 1, rue du Professeur-Calmette, BP 245, 59019 Lille cedex, France. Jean-michel.lecerf@pasteur-lille.fr
authors.forename: J-M
authors.initials: JM
authors.lastname: Lecerf
authors.forename: T
authors.initials: T
authors.lastname: Desmettre
mesh_terms: D002338:Carotenoids / Q000627:therapeutic use; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D006801:Humans; D008268:Macular Degeneration / Q000517:prevention & control*
chemical_list: D015525:Fatty Acids, Omega-3; D002338:Carotenoids