title: A novel biophysically-detailed mathematical model of rabbit Purkinje cell electrophysiology.
abstract: Purkinje fibres play an important role in cardiac conduction and have been implicated in arrhythmia in presence of diseased states, genetic mutations, or adverse side effects of drugs. For these reasons, the Purkinje assay is commonly used in pre-clinical in vitro drug assessment of arrhythmic risk. Several investigators have pointed out that rabbit Purkinje cells, compared to other species, have a better sensitivity in detecting arrhythmic risk.
authors.affiliation: Computing Laboratory, University of Oxford, Parks Road, OX13QD. United Kingdom. alberto@comlab.ox.ac.uk
authors.forename: Alberto
authors.initials: A
authors.lastname: Corrias
authors.forename: Blanca
authors.initials: B
authors.lastname: Rodriguez
mesh_terms: D000200:Action Potentials; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000175:diagnosis*; D001703:Biophysics / Q000379:methods; D003198:Computer Simulation; D004594:Electrophysiology / Q000379:methods; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D011689:Purkinje Cells / Q000473:pathology*; D011817:Rabbits; D012306:Risk; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry; D012984:Software
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase