title: Merging PK/PD information in a minimally parameterized model of the neuromuscular blockade.
abstract: A recursive system identification algorithm that merges PK/PD information in a minimally parameterized Wiener model for the NMB level is presented. The results show that the coupling between one parameter from the linear block and one from the static nonlinearity is advantageous, when evaluated on a database of 60 real collected NMB cases.
authors.affiliation: Faculdade de Ciências, Univ. Porto, Rua do Campo Alegre, 4169-007, Portugal. margarida.silva@fc.up.pt
authors.forename: Margarida
authors.initials: M
authors.lastname: Martins da Silva
authors.forename: Juliana
authors.initials: J
authors.lastname: Almeida
authors.forename: Torbjorn
authors.initials: T
authors.lastname: Wigren
authors.forename: Teresa
authors.initials: T
authors.lastname: Mendonca
mesh_terms: D000818:Animals; D001279:Atracurium / Q000493:pharmacokinetics* / Q000494:pharmacology*; D003198:Computer Simulation; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006801:Humans; D008657:Metabolic Clearance Rate; D008959:Models, Neurological; D019148:Neuromuscular Blockade / Q000379:methods*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000378:metabolism*; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium