title: Left dorsomedial frontal brain damage is associated with insomnia.
abstract: Insomnia is a common sleep disorder, yet its pathophysiological basis remains poorly understood. Studying a group of 192 patients with focal brain lesions, we show a significant association between insomnia and left dorsomedial prefrontal damage. Our findings are the first to demonstrate a link between insomnia and a discrete locus of brain damage, providing novel insight into the neurobiological mechanisms of sleep maintenance.
authors.affiliation: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA. mrkoenigs@wisc.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Koenigs
authors.forename: Jessica
authors.initials: J
authors.lastname: Holliday
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Solomon
authors.forename: Jordan
authors.initials: J
authors.lastname: Grafman
mesh_terms: D001925:Brain Damage, Chronic / Q000150:complications* / Q000473:pathology* / Q000523:psychology; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology* / Q000473:pathology* / Q000523:psychology; D014728:Veterans / Q000523:psychology; D047829:Vietnam Conflict