title: Relationship between two AMI risk factors: low serum lipoprotein lipase mass and hypoadiponectinemia.
abstract: OBJECTIVE
  Recent clinical studies have reported that low lipoprotein lipase mass in preheparin serum (s-LpL) and hypoadiponectinemia are important risk factors for acute myocardial infarction (AMI). The aim of this study was to elucidate the relationship between low s-LpL and hypoadiponectinemia, both of which are risk factors for AMI.
  
  
  METHODS
  One hundred and thirty-seven male patients with AMI and fifty-three males with normal coronary arteries (NCA) were enrolled in the study. Coronary risk factors, including s-LpL and serum total adiponectin concentrations (t-adiponectin), were compared.
  
  
  RESULTS
  Both s-LpL and t-adiponectin were significantly lower in patients with AMI than in subjects with NCA (s-LpL, NCA: 48.1±11.0 ng/mL, AMI: 38.9±11.1 ng/mL, p< 0.01; t-adiponectin, NCA: 7.7±2.9 µg/mL, AMI: 6.1±3.3 µg/mL, p< 0.01). In AMI patients, there was a significant positive correlation between s-LpL and t-adiponectin (r=0.46, p< 0.01). Furthermore, multivariate analysis indicated that both s-LpL and t-adiponectin were independent variables for AMI (s-LpL: p< 0.05, t-adiponectin: p< 0.05).
  
  
  CONCLUSIONS
  These results indicate that although low s-LpL and hypoadiponectinemia are associated with each other, they are independent risk factors for AMI.
authors.affiliation: The Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Sakura-City, Chiba, Japan. thitsu@jcom.home.ne.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hitsumoto
authors.forename: Mao
authors.initials: M
authors.lastname: Takahashi
authors.forename: Takuo
authors.initials: T
authors.lastname: Iizuka
authors.forename: Kohji
authors.initials: K
authors.lastname: Shirai
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D016022:Case-Control Studies; D017023:Coronary Angiography; D006801:Humans; D008071:Lipoprotein Lipase / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology*; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C548261:LPL protein, human; D008071:Lipoprotein Lipase