title: Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes.
abstract: Although the capability of DNA to form a variety of non-canonical (non-B) structures has long been recognized, the overall significance of these alternate conformations in biology has only recently become accepted en masse. In order to provide access to genome-wide locations of these classes of predicted structures, we have developed non-B DB, a database integrating annotations and analysis of non-B DNA-forming sequence motifs. The database provides the most complete list of alternative DNA structure predictions available, including Z-DNA motifs, quadruplex-forming motifs, inverted repeats, mirror repeats and direct repeats and their associated subsets of cruciforms, triplex and slipped structures, respectively. The database also contains motifs predicted to form static DNA bends, short tandem repeats and homo(purine•pyrimidine) tracts that have been associated with disease. The database has been built using the latest releases of the human, chimp, dog, macaque and mouse genomes, so that the results can be compared directly with other data sources. In order to make the data interpretable in a genomic context, features such as genes, single-nucleotide polymorphisms and repetitive elements (SINE, LINE, etc.) have also been incorporated. The database is accessed through query pages that produce results with links to the UCSC browser and a GBrowse-based genomic viewer. It is freely accessible at http://nonb.abcc.ncifcrf.gov.
authors.affiliation: Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick, Inc, NCI-Frederick, Frederick, MD 21702, USA.
authors.forename: Regina Z
authors.initials: RZ
authors.lastname: Cer
authors.forename: Kevin H
authors.initials: KH
authors.lastname: Bruce
authors.forename: Uma S
authors.initials: US
authors.lastname: Mudunuri
authors.forename: Ming
authors.initials: M
authors.lastname: Yi
authors.forename: Natalia
authors.initials: N
authors.lastname: Volfovsky
authors.forename: Brian T
authors.initials: BT
authors.lastname: Luke
authors.forename: Albino
authors.initials: A
authors.lastname: Bacolla
authors.forename: Jack R
authors.initials: JR
authors.lastname: Collins
authors.forename: Robert M
authors.initials: RM
authors.lastname: Stephens
mesh_terms: D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D030561:Databases, Nucleic Acid; D004285:Dogs; D023281:Genomics; D006801:Humans; D008251:Macaca; D051379:Mice; D009690:Nucleic Acid Conformation; D002679:Pan troglodytes / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004247:DNA