title: Overexpression of SGLT1 and EGFR in colorectal cancer showing a correlation with the prognosis.
abstract: Na+-dependent glucose cotransporter (SGLT1), reported overexpression in tumor tissues while its clinical significance was not established, and epidermal growth factor receptor (EGFR) with potential relation to SGLT1 were studied in order to investigate their clinical significance in colorectal cancer (CRC). Eighty-five patients of CRC who received chemotherapy in Sun Yat-sen Cancer Center from March 1st 2005 to December 31st 2008 were enrolled. SGLT1 and EGFR expression in these cancer tissues and 28 normal tissues were tested by immunohistochemistry. (1) Expression of SGLT1 (P = 0.00) and EGFR (P = 0.01) in cancer tissues was higher than that in normal tissues. (2) Their expression related with clinical stage (P = 0.03 and P = 0.02), but not with other clinical characteristics. (3) For first-line chemotherapy, expression of SGLT1 (P = 0.06 and P = 0.21) and EGFR (P = 0.37 and P = 0.31) had no influence on objective response rate (ORR) and disease control rate (DCR). EGFR overexpression was associated with lower disease-free survival (P = 0.00) and overall survival (P = 0.01), while SGLT1 did not (P = 0.79 and P = 0.34). Conclusions Both SGLT1 and EGFR overexpression in CRC was related to higher clinical stages. SGLT1 had a potential impact on the ORR of first-line chemotherapy in CRC. EGFR was associated with prognosis, while SGLT1 did not.
authors.affiliation: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou 510060, China.
authors.forename: Gui Fang
authors.initials: GF
authors.lastname: Guo
authors.forename: Yu Chen
authors.initials: YC
authors.lastname: Cai
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.forename: Rui Hua
authors.initials: RH
authors.lastname: Xu
authors.forename: Hui Juan
authors.initials: HJ
authors.lastname: Qiu
authors.forename: Liang Ping
authors.initials: LP
authors.lastname: Xia
authors.forename: Wen Qi
authors.initials: WQ
authors.lastname: Jiang
authors.forename: Pei Li
authors.initials: PL
authors.lastname: Hu
authors.forename: Xu Xian
authors.initials: XX
authors.lastname: Chen
authors.forename: Fei Fei
authors.initials: FF
authors.lastname: Zhou
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051269:Sodium-Glucose Transporter 1 / Q000378:metabolism*; D015996:Survival Rate; D055815:Young Adult
chemical_list: C495674:SLC5A1 protein, human; D051269:Sodium-Glucose Transporter 1; C512478:EGFR protein, human; D066246:ErbB Receptors