title: Eye movements in amyotrophic lateral sclerosis and its mimics: a review with illustrative cases.
abstract: Abnormal eye movements are increasingly recognised in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, key points with illustrative case histories and eye movement records are highlighted.
authors.affiliation: Department of Neurology, Royal Victoria Hospital, Belfast, UK. donaghy1a@hotmail.com
authors.forename: Colette
authors.initials: C
authors.lastname: Donaghy
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Thurtell
authors.forename: Erik P
authors.initials: EP
authors.lastname: Pioro
authors.forename: J Mark
authors.initials: JM
authors.lastname: Gibson
authors.forename: R John
authors.initials: RJ
authors.lastname: Leigh
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D018450:Disease Progression; D005133:Eye Movements / Q000502:physiology*; D005403:Fixation, Ocular / Q000502:physiology; D006801:Humans; D008297:Male; D009759:Nystagmus, Pathologic / Q000209:etiology; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009886:Ophthalmoplegia / Q000209:etiology; D012438:Saccades; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology