title: Implantable micropump technologies for murine intracochlear infusions.
abstract: Due to the very small size of the mouse inner ear, 600 nL volume, developing effective, controlled infusion systems is quite challenging. Key technologies have been created to minimize both size and power for an implantable pump for murine intracochlear infusions. A method for coupling fine capillary tubing to microfluidic channels is presented which provides low volume, biocompatible interconnects withstanding pressures as high as 827 kPa (120 psi) and consuming less than 20 nL of volume exiting in-plane with the pump. Surface micromachined resistive bridges integrated into the flow channel for anemometry based flow rate measurement have been optimized for low power operation in the ultra-low flow rate regime. A process for creation of deformable diaphragms over pump chambers with simultaneous coating of the microfluidic channels has been developed allowing integration of a biocompatible fluid flow path. These advances represent enabling capabilities for a drug delivery system suitable for space constrained applications such as subcutaneous implantation in mice.
authors.affiliation: Rochester Institute of Technology, Rochester, NY 14623, USA. dgj2607@rit.edu
authors.forename: D G
authors.initials: DG
authors.lastname: Johnson
authors.forename: M J
authors.initials: MJ
authors.lastname: Waldron
authors.forename: R D
authors.initials: RD
authors.lastname: Frisina
authors.forename: D A
authors.initials: DA
authors.lastname: Borkholder
mesh_terms: D000818:Animals; D003051:Cochlea; D004867:Equipment Design; D015918:Infusion Pumps, Implantable; D051379:Mice; D044085:Microfluidics / Q000379:methods