title: Catalytic C-H functionalization by metalloporphyrins: recent developments and future directions.
abstract: Metalloporphyrins are a class of versatile catalysts with the capability to functionalize saturated C-H bonds via several well-defined atom/group transfer processes, including oxene, nitrene, and carbene C-H insertions. The corresponding hydroxylation, amination, and alkylation reactions provide direct approaches for the catalytic conversion of abundant hydrocarbons into value-added functional molecules through C-O, C-N, and C-C bond formations, respectively. This tutorial review describes metalloporphyrin-based catalytic systems for the functionalization of different types of sp(3) C-H bonds, both inter- and intramolecularly, including challenging primary C-H bonds. Additional features of metalloporphyrin-catalyzed C-H functionalization include unusual selectivities and high turnover numbers.
authors.affiliation: Department of Chemistry, University of South Florida, Tampa, Florida 33620-5250, USA.
authors.forename: Hongjian
authors.initials: H
authors.lastname: Lu
authors.forename: X Peter
authors.initials: XP
authors.lastname: Zhang
mesh_terms: D000478:Alkylation; D000586:Amination; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D006900:Hydroxylation; D008665:Metalloporphyrins / Q000737:chemistry*
chemical_list: D008665:Metalloporphyrins; D002244:Carbon; D006859:Hydrogen