title: Emerging topics and new perspectives on HLA-G.
abstract: Following the Fifth International Conference on non-classical HLA-G antigens (HLA-G), held in Paris in July 2009, we selected some topics which focus on emerging aspects in the setting of HLA-G functions. In particular, HLA-G molecules could play a role in: (1) various inflammatory disorders, such as multiple sclerosis, intracerebral hemorrhage, gastrointestinal, skin and rheumatic diseases, and asthma, where they may act as immunoregulatory factors; (2) the mechanisms to escape immune surveillance utilized by several viruses, such as human cytomegalovirus, herpes simplex virus type 1, rabies virus, hepatitis C virus, influenza virus type A and human immunodeficiency virus 1 (HIV-1); and (3) cytokine/chemokine network and stem cell transplantation, since they seem to modulate cell migration by the downregulation of chemokine receptor expression and mesenchymal stem cell activity blocking of effector cell functions and the generation of regulatory T cells. However, the immunomodulatory circuits mediated by HLA-G proteins still remain to be clarified.
authors.affiliation: Neuroradiology Unit, Department of Neurosciences and Rehabilitation, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Corso della Giovecca 203, 44100 Ferrara, Italy. henryfai@tin.it
authors.forename: Enrico
authors.initials: E
authors.lastname: Fainardi
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Castellazzi
authors.forename: Marina
authors.initials: M
authors.lastname: Stignani
authors.forename: Fabio
authors.initials: F
authors.lastname: Morandi
authors.forename: Gwenaëlle
authors.initials: G
authors.lastname: Sana
authors.forename: Rafael
authors.initials: R
authors.lastname: Gonzalez
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
authors.forename: Olavio Roberto
authors.initials: OR
authors.lastname: Baricordi
authors.forename: Etienne
authors.initials: E
authors.lastname: Sokal
authors.forename: Josè
authors.initials: J
authors.lastname: Peña
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007157:Immunologic Surveillance; D056747:Immunomodulation; D007249:Inflammation / Q000276:immunology; D033581:Stem Cell Transplantation; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology
chemical_list: D016207:Cytokines; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I