title: Intrauterine demise due to congenital mesoblastic nephroma in a fetus conceived by assisted reproductive technology.
abstract: OBJECTIVE
  To report a case of antenatally diagnosed congenital mesoblastic nephroma in an assisted reproductive technology (ART) conception.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary care university-affiliated hospital.
  
  
  METHODS
  Fetus of 26-weeks' gestation with antenatally diagnosed large abdominal tumor.
  
  
  METHODS
  ART with transfer of cryopreserved embryo.
  
  
  METHODS
  Postmortem examination.
  
  
  RESULTS
  Examination revealed a congenital mesoblastic nephroma, mixed classic and cellular type, with marked intratumoral hemorrhage and associated hydrops. The marked fetal erythroblastosis was suggestive of fetal response to pronounced anemia. Intrauterine demise is attributed to fetal intratumoral hemorrhage and early nonimmune hydrops secondary to a large congenital mesoblastic nephroma.
  
  
  CONCLUSIONS
  This is the third reported case of congenital mesoblastic nephroma in an ART conception. Whether the association between mesoblastic nephroma and ART is coincidental or causative remains to be determined.
authors.affiliation: Department of Pathology, Women and Infants Hospital, Providence, Rhode Island 02905, USA. mdepaepe@wihri.org
authors.forename: Monique E
authors.initials: ME
authors.lastname: De Paepe
authors.forename: Svetlana
authors.initials: S
authors.lastname: Shapiro
authors.forename: Lawrence
authors.initials: L
authors.lastname: Young
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Carr
authors.forename: Fusun
authors.initials: F
authors.lastname: Gundogan
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D005307:Fertilization in Vitro; D005313:Fetal Death; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D018201:Nephroma, Mesoblastic / Q000473:pathology*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted