title: Textile-templated electrospun anisotropic scaffolds for tissue engineering and regenerative medicine.
abstract: Cardiovascular diseases, specifically myocardial infarction and end-stage heart failure represent some of the major pathologies that threaten human life. Here we present a novel approach for a bioactive cardiac patch based on a combination of biomedical and textile manufacturing techniques in concert with nano-biotechnology based tissue-engineering stratagems. The technological goal is to create BioNanoTextiles™ (BNT) by using "conventional" fabrics as templates for creating three-dimensional nanofibrous scaffolds. Electrospinning nanofibrous scaffolds templated after "ordinary" textiles is a novel way to create complex-patterned, 3-D scaffolds intrinsically mimicking some of the anisotropic structural features of the ventricular wall's extracellular matrix. In preliminary studies, we established that this approach will yield anisotropic 3-D scaffolds with mechanical properties dependent upon the yarn type of the textile-templates. These scaffolds are biocompatible, as inferred from their support of H9C2 cardiac myoblast adhesion which promotes their proliferation as well as cardiac-like anisotropic organization. The use of textile manufacturing strategies will enhance the complexity of the 3-D scaffold structures and enable their commercialization, while providing an opportunity for the textile industry to advance established "low-tech" manufacturing technologies into the realm of "high-tech" BioNanoTextiles.
authors.affiliation: Drexel University, School of Biomedical Engineering, Science and Health Systems, Philadelphia, PA 19104, USA. gozde.senel@drexel.edu
authors.forename: H G
authors.initials: HG
authors.lastname: Senel-Ayaz
authors.forename: A
authors.initials: A
authors.lastname: Perets
authors.forename: M
authors.initials: M
authors.lastname: Govindaraj
authors.forename: D
authors.initials: D
authors.lastname: Brookstein
authors.forename: P I
authors.initials: PI
authors.lastname: Lelkes
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D048430:Cell Shape / Q000502:physiology; D055664:Electrochemical Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D032446:Myoblasts / Q000166:cytology; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D044968:Regenerative Medicine / Q000379:methods*; D013784:Textiles; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials