title: Age-related changes in proliferation, the numbers of mast cells, eosinophils, and cd45-positive cells in human dermis.
abstract: Skin aging is an extremely important medical and social problem in the modern world. Therefore, a goal of the present work was to estimate changes in the numbers of fibroblast-like cells, proliferating cells nuclear antigen-positive cells, CD45-positive cells, mast cells, and eosinophils in human dermis at different ages. Skin specimens from human fetuses that died antenatally from 20 to 40 weeks of pregnancy and humans who died from different causes from 1 day to 85 years of life were used for the study. Results showed a decrease in a total number and the number of proliferating cells nuclear antigen-positive fibroblast-like cells in dermis with progression of age. The numbers of CD45-positive cells and mast cells are gradually increased with aging. Eosinophils are almost absent in dermis independently on age. Mast cells are probably a main factor that potentially can be involved in tissue damage and aging changes in skin. Mast cells should be regarded as an important target for anti-aging therapy.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, Chuvash State University, PO Box 86, Cheboksary 428034, Russia. drgunin@gmail.com
authors.forename: Andrei G
authors.initials: AG
authors.lastname: Gunin
authors.forename: Natalia K
authors.initials: NK
authors.lastname: Kornilova
authors.forename: Olga V
authors.initials: OV
authors.lastname: Vasilieva
authors.forename: Vadim V
authors.initials: VV
authors.lastname: Petrov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D020405:Dermis / Q000378:metabolism*; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007223:Infant; D017493:Leukocyte Common Antigens / Q000378:metabolism*; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D015595:Skin Aging; D055815:Young Adult
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human