title: Abdominal fat, adipose-derived hormones and mild cognitive impairment: the J-SHIPP study.
abstract: OBJECTIVE
  Lower body weight in later life has been shown to be associated with dementia. However, abdominal fat distribution under conditions of mild cognitive impairment (MCI) and the possible involvement of leptin and adiponectin in MCI have not been fully investigated.
  
  
  METHODS
  We analyzed 517 middle-aged-to-elderly community-dwelling persons. Abdominal subcutaneous fat and visceral fat areas were determined using computed tomography, and plasma leptin and adiponectin concentrations were measured in fasting samples. MCI was assessed using the Japanese version of the MCI screening method.
  
  
  RESULTS
  In men, the abdominal subcutaneous fat area was significantly lower in participants with MCI than in those with normal cognitive function [median (interquartile range): 107.4 (85.9, 133.1) cm² vs. 136.4 (93.1, 161.4) cm²; p = 0.002]. Logistic regression analyses with confounding factors including age and abdominal subcutaneous fat area showed that a 10 mg/l increase in plasma adiponectin had a protective effect against the development of MCI in men (odds ratio: 0.46; 95% CI: 0.20-0.97; p = 0.041). In contrast, MCI was not found to be associated with abdominal fat area or adipose-derived hormones in women.
  
  
  CONCLUSIONS
  Reduced amounts of subcutaneous fat and low levels of plasma adiponectin were found to be associated with MCI in men.
authors.affiliation: Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Tõon, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kamogawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Eri
authors.initials: E
authors.lastname: Uetani
authors.forename: Tokihisa
authors.initials: T
authors.lastname: Nagai
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Michiya
authors.initials: M
authors.lastname: Igase
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
mesh_terms: D050153:Abdominal Fat / Q000473:pathology*; D054392:Adipokines / Q000097:blood / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D003072:Cognition Disorders / Q000453:epidemiology / Q000378:metabolism* / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology / Q000523:psychology; D012307:Risk Factors; D012737:Sex Factors; D013739:Testosterone / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; D013739:Testosterone