title: Integrated software for the detection of epileptogenic zones in refractory epilepsy.
abstract: In this paper we present an integrated software designed to help nuclear medicine physicians in the detection of epileptogenic zones (EZ) by means of ictal-interictal SPECT and MR images. This tool was designed to be flexible, friendly and efficient. A novel detection method was included (A-contrario) along with the classical detection method (Subtraction analysis). The software's performance was evaluated with two separate sets of validation studies: visual interpretation of 12 patient images by an experimented observer and objective analysis of virtual brain phantom experiments by proposed numerical observers. Our results support the potential use of the proposed software to help nuclear medicine physicians in the detection of EZ in clinical practice.
authors.affiliation: Instituto de Ingeniería Eléctrica, Universidad de la República, Montevideo, Uruguay, 13000. fmiceli24@gmail.com
authors.forename: Alejandro
authors.initials: A
authors.lastname: Mottini
authors.forename: Franco
authors.initials: F
authors.lastname: Miceli
authors.forename: Germán
authors.initials: G
authors.lastname: Albin
authors.forename: Margarita
authors.initials: M
authors.lastname: Nuñez
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Ferrándo
authors.forename: Cecilia
authors.initials: C
authors.lastname: Aguerrebere
authors.forename: Alicia
authors.initials: A
authors.lastname: Fernandez
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000175:diagnosis*; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012984:Software; D013382:Subtraction Technique; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014584:User-Computer Interface; D055815:Young Adult