title: Comparing epileptiform behavior of mesoscale detailed models and population models of neocortex.
abstract: Two models of the neocortex are developed to study normal and pathologic neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons, and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar, synchronized behavior in this detailed model. This observation is captured by a population model that describes the activity of large neuronal populations with two differential equations with two delays. Both models appear to have similar sensitivity to variations of total network excitation. Analysis of the population model reveals the presence of multistability, which was also observed in various simulations of the detailed model.
authors.affiliation: Department of Applied Mathematics, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands. s.visser-1@math.utwente.nl
authors.forename: Sid
authors.initials: S
authors.lastname: Visser
authors.forename: Hil G E
authors.initials: HG
authors.lastname: Meijer
authors.forename: Hyong C
authors.initials: HC
authors.lastname: Lee
authors.forename: Wim
authors.initials: W
authors.lastname: van Drongelen
authors.forename: Michel J A M
authors.initials: MJ
authors.lastname: van Putten
authors.forename: Stephan A
authors.initials: SA
authors.lastname: van Gils
mesh_terms: D000200:Action Potentials / Q000502:physiology; D003198:Computer Simulation; D004827:Epilepsy / Q000473:pathology*; D006801:Humans; D008959:Models, Neurological; D019579:Neocortex / Q000473:pathology* / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000145:classification / Q000502:physiology*; D015203:Reproducibility of Results; D013569:Synapses / Q000502:physiology