title: Module detection in complex networks using integer optimisation.
abstract: BACKGROUND
  The detection of modules or community structure is widely used to reveal the underlying properties of complex networks in biology, as well as physical and social sciences. Since the adoption of modularity as a measure of network topological properties, several methodologies for the discovery of community structure based on modularity maximisation have been developed. However, satisfactory partitions of large graphs with modest computational resources are particularly challenging due to the NP-hard nature of the related optimisation problem. Furthermore, it has been suggested that optimising the modularity metric can reach a resolution limit whereby the algorithm fails to detect smaller communities than a specific size in large networks.
  
  
  RESULTS
  We present a novel solution approach to identify community structure in large complex networks and address resolution limitations in module detection. The proposed algorithm employs modularity to express network community structure and it is based on mixed integer optimisation models. The solution procedure is extended through an iterative procedure to diminish effects that tend to agglomerate smaller modules (resolution limitations).
  
  
  CONCLUSIONS
  A comprehensive comparative analysis of methodologies for module detection based on modularity maximisation shows that our approach outperforms previously reported methods. Furthermore, in contrast to previous reports, we propose a strategy to handle resolution limitations in modularity maximisation. Overall, we illustrate ways to improve existing methodologies for community structure identification so as to increase its efficiency and applicability.
authors.affiliation: Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King's College London, Strand, London, WC2R 2LS, UK. sophia.tsoka@kcl.ac.uk.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Laura
authors.initials: L
authors.lastname: Bennett
authors.forename: Lazaros G
authors.initials: LG
authors.lastname: Papageorgiou
authors.forename: Sophia
authors.initials: S
authors.lastname: Tsoka