title: Autonomic and metabolic effects of OSA in childhood obesity.
abstract: This study investigates the effects of exposure to intermittent hypoxia on cardiovascular autonomic control and metabolic function in obese children with obstructive sleep apnea (OSA). Each subject underwent: (1) a polysomnography; (2) morning fasting blood samples and a subsequent FSIVGTT; (3) noninvasive measurement of respiration, arterial blood pressure, and heart rate during supine and standing postures. Assessment of adiposity was performed using a DEXA scan. From these measurements, we deduced the pertinent sleep parameters, Bergman minimal model parameters and the parameters characterizing a minimal model of cardiovascular variability. Results suggest that intermittent hypoxia in OSA contributes independently to insulin resistance and autonomic dysfunction in overweight children.
authors.affiliation: University of Southern California, Department of Biomedical Engineering, DRB 140, Los Angeles, CA 90089, USA. foliveir@usc.edu
authors.forename: F M
authors.initials: FM
authors.lastname: Oliveira
authors.forename: W H
authors.initials: WH
authors.lastname: Tran
authors.forename: D
authors.initials: D
authors.lastname: Lesser
authors.forename: R
authors.initials: R
authors.lastname: Bhatia
authors.forename: R
authors.initials: R
authors.lastname: Ortega
authors.forename: S D
authors.initials: SD
authors.lastname: Mittelman
authors.forename: T G
authors.initials: TG
authors.lastname: Keens
authors.forename: S L
authors.initials: SL
authors.lastname: Davidson Ward
authors.forename: M C
authors.initials: MC
authors.lastname: Khoo
mesh_terms: D000293:Adolescent; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002648:Child; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D009765:Obesity / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology