title: [Chronic inflammatory and autoimmune mediated dermatoses during pregnancy. Course and prognosis for mother and child].
abstract: Chronic inflammatory dermatoses during pregnancy can take varying courses in mother and child. The dominant Th2-response characteristic for pregnancy may explain why atopic eczema or lupus erythematosus may deteriorate while psoriasis vulgaris may improve. In contrast, impetigo herpetiformis frequently shows a severe course. Lupus erythematosus and other autoantibody-triggered dermatoses like pemphigus vulgaris pose an increased risk for the child because of placental transfer of autoantibodies with specific skin changes or systemic manifestations of the disease as well as placental insufficiency, growth retardation and premature birth. Such risks are not associated with linear IgA dermatosis. A severe pityriasis rosea during the first 20 weeks of pregnancy may lead to an increased risk of abortion or premature delivery. Early diagnosis and individually adjusted therapy of skin diseases is mandatory to avoid any risk for mother or child.
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Universität Leipzig Anstalt öffentlichen Rechts, Ph.-Rosenthal-Str. 23, 04103, Leipzig. regina.renner@medizin.uni-leipzig.de
authors.forename: R
authors.initials: R
authors.lastname: Renner
authors.forename: M
authors.initials: M
authors.lastname: Sticherling
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D003131:Combined Modality Therapy; D003872:Dermatitis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D042241:Early Diagnosis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D007752:Obstetric Labor, Premature / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011379:Prognosis; D012307:Risk Factors; D012871:Skin Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014467:Ultraviolet Therapy
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents