title: Concise review: stem cells as an emerging platform for antibody therapy of cancer.
abstract: Monoclonal antibodies are important tools for cancer therapy, however, three factors limit their effectiveness: toxicity, poor tumor penetration, and inability to cross the blood-brain barrier. This review discusses the emerging field of stem cell-mediated antibody delivery and how this approach may improve antibody therapy of cancer by overcoming these obstacles.
authors.affiliation: Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010-3000, USA. rikfrank@gmail.com
authors.forename: Richard T
authors.initials: RT
authors.lastname: Frank
authors.forename: Joseph
authors.initials: J
authors.lastname: Najbauer
authors.forename: Karen S
authors.initials: KS
authors.lastname: Aboody
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D000906:Antibodies