title: Electropolymerization molecularly imprinted polymer (E-MIP) SPR sensing of drug molecules: pre-polymerization complexed terthiophene and carbazole electroactive monomers.
abstract: A novel chemosensitive ultrathin film with high selectivity was developed for the detection of naproxen, paracetamol, and theophylline using non-covalent electropolymerized molecular imprinted polymers (E-MIP). A series of monofunctional and bifunctional H-bonding terthiophene and carbazole monomers were compared for imprinting these drugs without the use of a separate cross-linker. A key step is the fast and efficient potentiostatic method of washing the template, which facilitated enhanced real-time sensing by surface plasmon resonance (SPR) spectroscopy. Various surface characterizations (contact angle, ellipsometry, XPS, AFM) of the E-MIP film verified the templating and release of the drug from the cross-linked conducting polymer film.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204-5003, United States.
authors.forename: Roderick
authors.initials: R
authors.lastname: Pernites
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Ponnapati
authors.forename: Mary Jane
authors.initials: MJ
authors.lastname: Felipe
authors.forename: Rigoberto
authors.initials: R
authors.lastname: Advincula
mesh_terms: D002227:Carbazoles / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015336:Molecular Probe Techniques / Q000295:instrumentation*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000379:methods*; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D002227:Carbazoles; D004364:Pharmaceutical Preparations; D011108:Polymers; D013876:Thiophenes; C041514:carbazole; C019101:alpha-terthienyl