title: Synthetic oligodeoxynucleotide purification by polymerization of failure sequences.
abstract: Synthetic oligodeoxynucleotide is purified by capping failure sequences with an acrylated phosphoramidite followed by polymerization and product extraction. The method is suitable for large scale oligonucleotide drug purification.
authors.affiliation: Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA. shifang@mtu.edu
authors.forename: Shiyue
authors.initials: S
authors.lastname: Fang
authors.forename: Suntara
authors.initials: S
authors.lastname: Fueangfung
authors.forename: Xi
authors.initials: X
authors.lastname: Lin
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Mai
authors.forename: Lanrong
authors.initials: L
authors.lastname: Bi
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Green
mesh_terms: D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D009943:Organophosphorus Compounds / Q000737:chemistry; D058105:Polymerization
chemical_list: D009838:Oligodeoxyribonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite