title: Effects of time varying currents and magnetic fields in the frequency range of 1 kHz to 1 MHz to the human body - a simulation study.
abstract: Exposure to time-varying magnetic fields evokes two effects in biological tissue: Firstly, an electric field is induced that generates eddy currents in conductive tissues, and, secondly, power deposit might increase local temperatures. Field effects of frequencies up to 1 kHz and above 1 MHz are well known. The intermediate frequency range lacks intensive research. Only little attention has been paid so far. Yet due to recent innovations in medical diagnostics and therapies like Magnetic Particle Imaging or RF-Hyperthermia, the need arises to investigate the frequency range from 1kHz to 1 MHz. This work presents results of numerical field calculations of a human body model placed within simple coil configurations. Induced current densities, generated by alternating coil currents, are simulated. The effect of current densities are demonstrated and evaluated on schematic cell models of excitable tissue. In order to generate an action potential at the cell membrane, a difference in electric potential from intra- to extracellular space must be present. It can be shown that in case of sufficient field strength, stimulation of nerves and muscles is possible up to a frequency of 100 kHz. The aim of this paper is to transfer simulation results from the macroscopic model to the microscopic model in order to estimate field effects of big field generating coils.
authors.affiliation: Institute of Biomedical Engineering, Karlsruhe Institute of Technology, 76128, Germany. julia.bohnert@kit.edu
authors.forename: Julia
authors.initials: J
authors.lastname: Bohnert
authors.forename: Olaf
authors.initials: O
authors.lastname: Dössel
mesh_terms: D004574:Electromagnetic Fields; D018594:Human Body; D006801:Humans; D051598:Whole Body Imaging