title: Tracheobronchomalacia in adults.
abstract: Severe, diffuse tracheobronchomalacia (TBM) is an underrecognized cause of dyspnea, recurrent respiratory infections, cough, secretion retention, and even respiratory insufficiency. Patients often have comorbidities, such as asthma or chronic obstructive pulmonary disease, and inappropriate treatment for these conditions may precede eventual recognition of TBM by months or years. Most of these patients have an acquired form of TBM in which the etiology in unknown. Diagnosis of TBM is made by airway computed tomography scan and flexible bronchoscopy with forced expiration. The prevailing definition of TBM as a 50% reduction in cross-sectional area is nonspecific, with a high proportion of healthy volunteers meeting this threshold. The clinically significant threshold is complete or near-complete collapse of the airway. Airway stenting may treat TBM, although complications resulting from indwelling prostheses often limit the durability of stents. Surgical stabilization of the airway by posterior splinting (tracheobronchoplasty) effectively and permanently corrects malacic airways. Proper surgical selection is facilitated by a short-term stent trial.
authors.affiliation: Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. sgangadh@bidmc.harvard.edu
authors.forename: Sidhu P
authors.initials: SP
authors.lastname: Gangadharan
mesh_terms: D000328:Adult; D001999:Bronchoscopy / Q000295:instrumentation; D015897:Comorbidity; D006801:Humans; D012307:Risk Factors; D015607:Stents; D019616:Thoracic Surgical Procedures; D055089:Tracheobronchomalacia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome