title: The many faces of S100B protein: when an extracellular factor inactivates its own receptor and activates another one.
abstract: The Ca(2+)-binding protein of the EF-hand type, S100B, is an intracellular regulator and an extracellular signal. Within cells S100B interacts with several proteins thereby regulating energy metabolism, Ca2+ homeostasis, protein phosphorylation and degradation, and cell locomotion, proliferation and differentiation. Once secreted/released, S100B exerts autocrine and paracrine effects on responsive cells by engaging the receptor for advanced glycation end products. However, recent evidence suggests that S100B might also activate basic fibroblast growth factor receptor 1 via prior binding to basic fibroblast growth factor.
authors.affiliation: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia.
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Sorci
authors.forename: Francesca
authors.initials: F
authors.lastname: Riuzzi
authors.forename: Cataldo
authors.initials: C
authors.lastname: Arcuri
authors.forename: Roberta
authors.initials: R
authors.lastname: Bianchi
authors.forename: Flora
authors.initials: F
authors.lastname: Brozzi
authors.forename: Claudia
authors.initials: C
authors.lastname: Tubaro
authors.forename: Ileana
authors.initials: I
authors.lastname: Giambanco
authors.forename: Rosario
authors.initials: R
authors.lastname: Donato
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D045604:Extracellular Fluid / Q000378:metabolism* / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D000067759:Receptor for Advanced Glycation End Products; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000502:physiology; D011971:Receptors, Immunologic / Q000502:physiology; D017475:Receptors, Nerve Growth Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D017475:Receptors, Nerve Growth Factor; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1