title: Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate.
abstract: Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology. Ancestral architecture of animal genomes can be deeply modified and may therefore be largely nonadaptive. This rapidly evolving animal lineage thus offers unique perspectives on the level of genome plasticity. It also illuminates issues as fundamental as the mechanisms of intron gain.
authors.affiliation: Commissariat à l'Énergie Atomique, Institut de Génomique, Genoscope, Evry, France.
authors.forename: France
authors.initials: F
authors.lastname: Denoeud
authors.forename: Simon
authors.initials: S
authors.lastname: Henriet
authors.forename: Sutada
authors.initials: S
authors.lastname: Mungpakdee
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Aury
authors.forename: Corinne
authors.initials: C
authors.lastname: Da Silva
authors.forename: Henner
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authors.lastname: Brinkmann
authors.forename: Jana
authors.initials: J
authors.lastname: Mikhaleva
authors.forename: Lisbeth Charlotte
authors.initials: LC
authors.lastname: Olsen
authors.forename: Claire
authors.initials: C
authors.lastname: Jubin
authors.forename: Cristian
authors.initials: C
authors.lastname: Cañestro
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Bouquet
authors.forename: Gemma
authors.initials: G
authors.lastname: Danks
authors.forename: Julie
authors.initials: J
authors.lastname: Poulain
authors.forename: Coen
authors.initials: C
authors.lastname: Campsteijn
authors.forename: Marcin
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authors.forename: Ismael
authors.initials: I
authors.lastname: Cross
authors.forename: Fekadu
authors.initials: F
authors.lastname: Yadetie
authors.forename: Matthieu
authors.initials: M
authors.lastname: Muffato
authors.forename: Alexandra
authors.initials: A
authors.lastname: Louis
authors.forename: Stephen
authors.initials: S
authors.lastname: Butcher
authors.forename: Georgia
authors.initials: G
authors.lastname: Tsagkogeorga
authors.forename: Anke
authors.initials: A
authors.lastname: Konrad
authors.forename: Sarabdeep
authors.initials: S
authors.lastname: Singh
authors.forename: Marit Flo
authors.initials: MF
authors.lastname: Jensen
authors.forename: Evelyne
authors.initials: E
authors.lastname: Huynh Cong
authors.forename: Helen
authors.initials: H
authors.lastname: Eikeseth-Otteraa
authors.forename: Benjamin
authors.initials: B
authors.lastname: Noel
authors.forename: Véronique
authors.initials: V
authors.lastname: Anthouard
authors.forename: Betina M
authors.initials: BM
authors.lastname: Porcel
authors.forename: Rym
authors.initials: R
authors.lastname: Kachouri-Lafond
authors.forename: Atsuo
authors.initials: A
authors.lastname: Nishino
authors.forename: Matteo
authors.initials: M
authors.lastname: Ugolini
authors.forename: Pascal
authors.initials: P
authors.lastname: Chourrout
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishida
authors.forename: Rein
authors.initials: R
authors.lastname: Aasland
authors.forename: Snehalata
authors.initials: S
authors.lastname: Huzurbazar
authors.forename: Eric
authors.initials: E
authors.lastname: Westhof
authors.forename: Frédéric
authors.initials: F
authors.lastname: Delsuc
authors.forename: Hans
authors.initials: H
authors.lastname: Lehrach
authors.forename: Richard
authors.initials: R
authors.lastname: Reinhardt
authors.forename: Jean
authors.initials: J
authors.lastname: Weissenbach
authors.forename: Scott W
authors.initials: SW
authors.lastname: Roy
authors.forename: François
authors.initials: F
authors.lastname: Artiguenave
authors.forename: John H
authors.initials: JH
authors.lastname: Postlethwait
authors.forename: J Robert
authors.initials: JR
authors.lastname: Manak
authors.forename: Eric M
authors.initials: EM
authors.lastname: Thompson
authors.forename: Olivier
authors.initials: O
authors.lastname: Jaillon
authors.forename: Louis
authors.initials: L
authors.lastname: Du Pasquier
authors.forename: Pierre
authors.initials: P
authors.lastname: Boudinot
authors.forename: David A
authors.initials: DA
authors.lastname: Liberles
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Volff
authors.forename: Hervé
authors.initials: H
authors.lastname: Philippe
authors.forename: Boris
authors.initials: B
authors.lastname: Lenhard
authors.forename: Hugues
authors.initials: H
authors.lastname: Roest Crollius
authors.forename: Patrick
authors.initials: P
authors.lastname: Wincker
authors.forename: Daniel
authors.initials: D
authors.lastname: Chourrout
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004251:DNA Transposable Elements; D021901:DNA, Intergenic; D005091:Exons; D023061:Gene Order; D020131:Genes, Duplicate; D005801:Genes, Homeobox; D016678:Genome; D007438:Introns; D007448:Invertebrates / Q000145:classification / Q000235:genetics; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D017381:Spliceosomes / Q000378:metabolism; D026801:Synteny; D014561:Urochordata / Q000033:anatomy & histology / Q000145:classification / Q000235:genetics* / Q000276:immunology; D014714:Vertebrates / Q000145:classification / Q000235:genetics
chemical_list: D004251:DNA Transposable Elements; D021901:DNA, Intergenic