title: [Risk factors of novel severe influenza A(H1N1) with concurrent adult respiratory distress syndrome].
abstract: OBJECTIVE
  To analyze the risk factors of novel severe influenza A (H1N1) with concurrent adult respiratory distress syndrome (ARDS).
  
  
  METHODS
  A multivariable Logistic regression analysis was conducted for ARDS risk factors in controlled clinical trials for comparing the clinical features between the ARDS and non-ARDS groups and comparing ARDS patients' lymphocyte counts and T lymphocyte subsets between the smoking and non-smoking groups through a retrospective analysis of 92 novel influenza A (H1N1) patients who admitted to our hospital from October 2009 to January 2010.
  
  
  RESULTS
  Through a single factor analysis between ARDS and non-ARDS groups, the comparisons in the factors including smoking (17 cases vs 11 cases), T lymphocyte subsets, lactate dehydrogenase (LDH), initial treatment point of oseltamivir and initial oxygen flow greater than 2 L/min (28 cases vs 18 cases) had statistically significant differences (all P<0.05). The comparison in T lymphocyte subsets had statistically significant difference between the smoking and non-smoking groups in ARDS patients (all P<0.05). The multivariable Logistic regression analysis showed that smoking (P=0.027, OR=8.05, 95%CI: 1.28-50.80) and initial oxygen flow greater than 2 L/min (P=0.010, OR=16.70, 95%CI: 3.29-84.84) were relevant to the incidence of ARDS in novel influenza A (H1N1) patients.
  
  
  CONCLUSIONS
  Smoking and initial oxygen flow greater than 2 L/min were the risk factors of novel severe influenza A (H1N1) with concurrent ARDS.
authors.affiliation: Department of Respiratory Medicine, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Dai
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
authors.forename: Zan-feng
authors.initials: ZF
authors.lastname: Wang
authors.forename: De-lei
authors.initials: DL
authors.lastname: Kong
authors.forename: Wei
authors.initials: W
authors.lastname: Tan
authors.forename: Hong-wen
authors.initials: HW
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications* / Q000453:epidemiology; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D012128:Respiratory Distress Syndrome / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking; D055815:Young Adult