title: Stereoselective synthesis of the C15-C26 fragment of the antitumor agent (-)-dictyostatin.
abstract: The synthesis of the C15-C26 fragment of (-)-dictyostatin is reported in 10 steps and 28% overall yield. The key steps are the two stereoselective sulfoxide-directed processes: a Reformatsky-type reaction and a β-keto sulfoxide reduction.
authors.affiliation: Departamento de Química Orgánica (Módulo 01), Universidad Autónoma de Madrid, 28049, Madrid, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Ferreiro-Mederos
authors.forename: Silvia
authors.initials: S
authors.lastname: Vila-Gisbert
authors.forename: Antonio
authors.initials: A
authors.lastname: Urbano
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Carreño
authors.forename: Françoise
authors.initials: F
authors.lastname: Colobert
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D018942:Macrolides / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; C470814:dictyostatin