title: Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.
abstract: The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon-ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.
authors.affiliation: Hospital Carlos III, Madrid, Spain bDuke Clinical Research Institute, Durham, North Carolina, USA.
authors.forename: Norma I
authors.initials: NI
authors.lastname: Rallon
authors.forename: Clara
authors.initials: C
authors.lastname: Restrepo
authors.forename: Susanna
authors.initials: S
authors.lastname: Naggie
authors.forename: Mariola
authors.initials: M
authors.lastname: Lopez
authors.forename: Jorge
authors.initials: J
authors.lastname: Del Romero
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.forename: John
authors.initials: J
authors.lastname: McHutchison
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
authors.forename: Jose M
authors.initials: JM
authors.lastname: Benito
mesh_terms: D015496:CD4-Positive T-Lymphocytes; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012367:RNA, Viral; D018570:Risk Assessment; D019562:Viral Load; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; D012367:RNA, Viral; C000624353:interferon-lambda, human; D000095022:Interferon Lambda