title: Kinetics of inflammatory markers following cancer-related bowel and liver resection.
abstract: BACKGROUND
  Macrophage migration inhibitory factor (MIF) was originally described as a cytokine that inhibits migration of macrophages at the site of inflammation. Subsequently it was also identified as a stress-induced hormone released from the anterior pituitary lobe in response to some pro-inflammatory stimuli like endotoxins and tumour necrosis factor (TNF-α).
  
  
  OBJECTIVE
  To compare postoperative changes in serum MIF levels of patients undergoing bowel and liver resections. It has clinical relevance to describe the kinetics of this crucial mediator of systemic inflammation in surgery.
  
  
  METHODS
  A total of 58 patients were studied over 4 years. Group A (28 patients) underwent only hepatic resection without enterotomy. Group B (30 patients) had bowel resection with enterotomy. MIF, IL-1β, IL-8, prealbumin, albumin, α1-glycoprotein, fibrinogen, and C-reactive protein levels were measured preoperatively, immediately following surgery, and postoperatively for three consecutive days. To evaluate organ functions, multiple organ dysfunction score was used.
  
  
  RESULTS
  A significantly higher level of MIF (4,505 pg/mL) was found in group A when compared to that of group B immediately following surgery. Other parameters monitored in this study were not statistically different between the two groups.
  
  
  CONCLUSIONS
  Higher elevations in MIF levels with liver resections, compared to bowel resections, might be attributable to MIF release from damaged liver cells. The presumably minimal endotoxin exposure during bowel surgery was either insufficient or inefficient to induce relevant MIF elevations in our patients. To fully delineate implications of this finding further studies are needed.
authors.affiliation: University of Pécs, Department of Anaesthesiology and Intensive Therapy, Pécs, Hungary.
authors.forename: Sándor
authors.initials: S
authors.lastname: Márton
authors.forename: János
authors.initials: J
authors.lastname: Garai
authors.forename: Valéria
authors.initials: V
authors.lastname: Molnár
authors.forename: Vera
authors.initials: V
authors.lastname: Juhász
authors.forename: Lajos
authors.initials: L
authors.lastname: Bogár
authors.forename: Tamás
authors.initials: T
authors.lastname: Köszegi
authors.forename: Boglárka
authors.initials: B
authors.lastname: Falusi
authors.forename: Subhamay
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000328:Adult; D000368:Aged; D002116:Calcitonin / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D008263:Macrophage Migration-Inhibitory Factors; D011498:Protein Precursors; D014409:Tumor Necrosis Factor-alpha; D002116:Calcitonin