title: LKB1 regulated pathways in lung cancer invasion and metastasis.
abstract: Metastasis is characterized by the ability of cancer cells to invade into adjacent tissue, intravasate into blood or lymphatic vessels, and extravasate into a distant tissue. Metastatic disease is primarily responsible for the low 5-year survival rate of non-small cell lung cancer (NSCLC), and therefore, an understanding of the molecular mechanisms that regulate NSCLC metastasis is clearly warranted. The serine/threonine kinase and tumor suppressor LKB1 is mutated in 30% of NSCLC tumors, and recent evidence points to a prominent role in NSCLC metastasis. This review summarizes LKB1-dependent invasion pathways where compromised LKB1 function could promote NSCLC metastasis.
authors.affiliation: Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA. aimarcu@emory.edu
authors.forename: Adam I
authors.initials: AI
authors.lastname: Marcus
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases / Q000502:physiology; D023102:Anoikis; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology; D002448:Cell Adhesion; D016764:Cell Polarity; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases