title: Clinical map document based on XML (cMDX): document architecture with mapping feature for reporting and analysing prostate cancer in radical prostatectomy specimens.
abstract: BACKGROUND
  The pathology report of radical prostatectomy specimens plays an important role in clinical decisions and the prognostic evaluation in Prostate Cancer (PCa). The anatomical schema is a helpful tool to document PCa extension for clinical and research purposes. To achieve electronic documentation and analysis, an appropriate documentation model for anatomical schemas is needed. For this purpose we developed cMDX.
  
  
  METHODS
  The document architecture of cMDX was designed according to Open Packaging Conventions by separating the whole data into template data and patient data. Analogue custom XML elements were considered to harmonize the graphical representation (e.g. tumour extension) with the textual data (e.g. histological patterns). The graphical documentation was based on the four-layer visualization model that forms the interaction between different custom XML elements. Sensible personal data were encrypted with a 256-bit cryptographic algorithm to avoid misuse. In order to assess the clinical value, we retrospectively analysed the tumour extension in 255 patients after radical prostatectomy.
  
  
  RESULTS
  The pathology report with cMDX can represent pathological findings of the prostate in schematic styles. Such reports can be integrated into the hospital information system. "cMDX" documents can be converted into different data formats like text, graphics and PDF. Supplementary tools like cMDX Editor and an analyser tool were implemented. The graphical analysis of 255 prostatectomy specimens showed that PCa were mostly localized in the peripheral zone (Mean: 73% ± 25). 54% of PCa showed a multifocal growth pattern.
  
  
  CONCLUSIONS
  cMDX can be used for routine histopathological reporting of radical prostatectomy specimens and provide data for scientific analysis.
authors.affiliation: Prostate Center, Dept. of Urology, University Hospital Muenster, Germany. eminaga@uni-muenster.de
authors.forename: Okyaz
authors.initials: O
authors.lastname: Eminaga
authors.forename: Reemt
authors.initials: R
authors.lastname: Hinkelammert
authors.forename: Axel
authors.initials: A
authors.lastname: Semjonow
authors.forename: Joerg
authors.initials: J
authors.lastname: Neumann
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Abbas
authors.forename: Thomas
authors.initials: T
authors.lastname: Koepke
authors.forename: Olaf
authors.initials: O
authors.lastname: Bettendorf
authors.forename: Elke
authors.initials: E
authors.lastname: Eltze
authors.forename: Martin
authors.initials: M
authors.lastname: Dugas
mesh_terms: D000465:Algorithms; D004282:Documentation / Q000379:methods*; D057286:Electronic Health Records; D006751:Hospital Information Systems; D006801:Humans; D019146:Hypermedia; D008297:Male; D011381:Programming Languages; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D012189:Retrospective Studies