title: [The clinical characteristics and prognosis of non ST segment elevation acute coronary syndrome in different genders].
abstract: OBJECTIVE
  To determine gender differences in baseline characteristics and intervention treatment in relation to prognosis in patients with non-ST segment elevation acute coronary syndrome (NSTEACS).
  
  
  METHODS
  A total of 814 patients (545 men and 269 women) with NSTEACS were randomized to early intervention (coronary angiography < 24 hours after randomization) or delayed intervention (coronary angiography > 36 hours after randomization). The primary outcome was a composite of death, myocardial infarction, or stroke at 6 months.
  
  
  RESULTS
  Women were older and more frequently had hypertension, diabetes, and history of coronary artery disease (CAD) or chronic angina (P < 0.05 for all). Women less were smokers and had elevations in cardiac marker (P < 0.05 for both). Women who underwent angiography had no significant lesions more often, but the left main stem and/or three-vessel diseases were similar with men. In adjusted multiple logistic regression analysis, the previous myocardial infarction and severe coronary artery disease were independently associated with the risk of primary endpoint in women. On multivariate analysis for men, severe coronary artery disease delayed intervention strategy and at least 3 risk factors for CAD were independently associated with the risk of primary endpoint.
  
  
  CONCLUSIONS
  In NSTEACS patients, different gender had the different prognostic predictor. Severe coronary diseases were as an independent predictor for both male and female patients. An early intervention strategy resulted in a beneficial effect in men which was not seen in women.
authors.affiliation: Peking Union Medical College and Chinese Academy of Medical Science, Fuwai Hospital, Beijing 100037, China.
authors.forename: Chun-li
authors.initials: CL
authors.lastname: Shao
authors.forename: Shu-bin
authors.initials: SB
authors.lastname: Qiao
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Jue
authors.initials: J
authors.lastname: Chen
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Wen-jia
authors.initials: WJ
authors.lastname: Zhang
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000628:therapy*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012737:Sex Factors