title: Database of genetic studies of bipolar disorder.
abstract: This study describes the construction and preliminary analysis of a database of summary level genetic findings for bipolar disorder from the literature. The database is available for noncommercial use at http://bioprogramming.bsd.uchicago.edu/BDStudies/. This may be the first complete collection of published gene-specific linkage and association findings on bipolar disorder, including genome-wide association studies. Both the positive and negative findings have been incorporated so that the statistical and contextual significance of each finding may be compared semi-quantitatively and qualitatively across studies of mixed technologies. The database is appropriate for searching a literature populated by mainly underpowered studies, and if 'hits' are viewed as tentative knowledge for future hypothesis generation. It can serve as the basis for a mega-analysis of candidate genes. Herein, we discuss the most robust and best replicated gene findings to date in a contextual manner.
authors.affiliation: Department of Psychiatry, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA. jpiletz@lumc.edu
authors.forename: John E
authors.initials: JE
authors.lastname: Piletz
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Zhang
authors.forename: Rajdeep
authors.initials: R
authors.lastname: Ranade
authors.forename: Chunyu
authors.initials: C
authors.lastname: Liu
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D030541:Databases, Genetic; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans