title: Impedimetric biosignal analysis and quantification in a real-time biosensor system.
abstract: We describe our real-time, label-free, electrochemical impedance biosensor system with an emphasis on the use of an impedance response signal model to quantify assays. The signal processing for estimating model parameters from noisy data and the quantitative verification against target concentration and affinity are also presented.
authors.affiliation: Sharp Laboratories of America, 5750 NW Pacific Rim Blvd, Camas, Washington 98607, USA. deanm@sharplabs.com
authors.forename: Dean S
authors.initials: DS
authors.lastname: Messing
authors.forename: Andrey
authors.initials: A
authors.lastname: Ghindilis
authors.forename: Kevin
authors.initials: K
authors.lastname: Schwarzkopf
mesh_terms: D000465:Algorithms; D015374:Biosensing Techniques; D003201:Computers; D004277:DNA, Single-Stranded / Q000235:genetics; D017097:Electric Impedance; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D004867:Equipment Design; D004926:Escherichia coli / Q000235:genetics; D007700:Kinetics; D017711:Nonlinear Dynamics; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
chemical_list: D004277:DNA, Single-Stranded