title: Rapid release of plasmid DNA from polyelectrolyte multilayers: a weak poly(acid) approach.
abstract: We demonstrate an approach to the assembly of DNA-containing polyelectrolyte multilayers that can be used to promote rapid release of DNA from surfaces. The approach is based on layer-by-layer incorporation of poly(acrylic acid) to promote rapid erosion in physiologically relevant media.
authors.affiliation: Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI 53706, USA.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Flessner
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: David M
authors.initials: DM
authors.lastname: Lynn
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D004247:DNA / Q000737:chemistry*; D004573:Electrolytes / Q000737:chemistry; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D004573:Electrolytes; C006903:carbopol 940; D004247:DNA