title: Identification of intracellular calcium dynamics in stimulated cardiomyocytes.
abstract: We have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images. The method allows the identification of different dynamical patterns such as spatially concordant and discordant alternans, irregular behavior or phase-locking regimes such as period doubling or halving. The method can be applied to the analysis of different cardiac pathologies related to anomalies at the cellular level such as ventricular reentrant arrhythmias.
authors.affiliation: Automatic Control Department, Universitat Politecnica de Catalunya (UPC), Barcelona, Spain. alex.vallmitjana@upc.edu
authors.forename: A
authors.initials: A
authors.lastname: Vallmitjana
authors.forename: M
authors.initials: M
authors.lastname: Barriga
authors.forename: Z
authors.initials: Z
authors.lastname: Nenadic
authors.forename: A
authors.initials: A
authors.lastname: Llach
authors.forename: E
authors.initials: E
authors.lastname: Alvarez-Lacalle
authors.forename: L
authors.initials: L
authors.lastname: Hove-Madsen
authors.forename: R
authors.initials: R
authors.lastname: Benitez
mesh_terms: D002118:Calcium / Q000737:chemistry / Q000378:metabolism*; D002478:Cells, Cultured; D006651:Histocytochemistry / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D042541:Intracellular Space / Q000737:chemistry / Q000378:metabolism; D018613:Microscopy, Confocal / Q000379:methods*; D032383:Myocytes, Cardiac / Q000737:chemistry / Q000378:metabolism*; D025341:Principal Component Analysis
chemical_list: D002118:Calcium