title: Retention of conditioning agent hyaluronan on hydrogel contact lenses.
abstract: Hyaluronan, a member of the glycosaminoglycan family of biological polysaccharides, is a high-molecular-weight disaccharide polymer found throughout the human body, particularly in the eye. Bausch+Lomb Biotrue™ multi-purpose solution contains hyaluronan as a lens conditioning agent. The retention of hyaluronan from Biotrue multi-purpose solution to a variety of hydrogel contact lenses was evaluated over time. Fluorescein-tagged hyaluronan was allowed to adhere to lenses, which were then rinsed with balanced salt solution at a rate comparable to human tear secretion. Results demonstrated that hyaluronan was released slowly throughout the rinse period. The chemistry of the lens materials appeared to contribute to the hyaluronan retention capacity for each lens type. The results suggest that a multi-purpose solution containing hyaluronan has the potential to provide lens conditioning regardless of the hydrogel contact lens used.
authors.affiliation: Bausch & Lomb Incorporated, 1400 North Goodman Street, Rochester, NY 14609, USA. catherine a scheuer@bausch.com
authors.forename: C A
authors.initials: CA
authors.lastname: Scheuer
authors.forename: K M
authors.initials: KM
authors.lastname: Fridman
authors.forename: V L
authors.initials: VL
authors.lastname: Barniak
authors.forename: S E
authors.initials: SE
authors.lastname: Burke
authors.forename: S
authors.initials: S
authors.lastname: Venkatesh
mesh_terms: D000042:Absorption; D018639:Contact Lens Solutions / Q000737:chemistry*; D003261:Contact Lenses; D019544:Equipment Failure Analysis; D006820:Hyaluronic Acid / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing
chemical_list: D018639:Contact Lens Solutions; D020100:Hydrogels; D006820:Hyaluronic Acid