title: A Case of Cryptococcal Lymphadenitis in an HIV-Infected Child.
abstract: An 8-year-old HIV-positive antiretroviral therapy-naive child developed severe headache and generalized lymphadenopathy. The serum cryptococcal antigen (CRAG) test was positive, the histology on the lymph node biopsy revealed budding yeast cells, and Cryptococcus neoformans was isolated on culture of his cerebrospinal fluid. He was treated with intravenous amphotericin B followed by oral fluconazole with a good response. Therefore cryptococcal lymphadenitis should be considered in the differential diagnosis of children presenting with lymphadenopathy and a positive serum CRAG.
authors.affiliation: Joint Clinical Research Centre , Kampala, Uganda.
authors.forename: Eva
authors.initials: E
authors.lastname: Natukunda
authors.forename: Victor
authors.initials: V
authors.lastname: Musiime
authors.forename: Francis
authors.initials: F
authors.lastname: Ssali
authors.forename: Hilda
authors.initials: H
authors.lastname: Kizito
authors.forename: Cissy
authors.initials: C
authors.lastname: Kityo
authors.forename: Peter
authors.initials: P
authors.lastname: Mugyenyi
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D000946:Antigens, Fungal / Q000097:blood; D001921:Brain / Q000000981:diagnostic imaging; D002648:Child; D003453:Cryptococcosis / Q000175:diagnosis* / Q000473:pathology; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D015725:Fluconazole / Q000008:administration & dosage; D015658:HIV Infections / Q000150:complications*; D006651:Histocytochemistry; D006801:Humans; D008199:Lymphadenitis / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008853:Microscopy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D000666:Amphotericin B; D015725:Fluconazole