title: Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus.
abstract: A family of novel bitriazolyl acyclonucleosides were synthesized using a simple and convenient one-step synthetic procedure via the Huisgen reaction by addition of NaN(3) onto triazole nucleosides bearing internal alkynyl groups introduced at the 5-position of the triazole ring. Some of the compounds exhibited interesting antiviral activity against tobacco mosaic virus, demonstrating the importance of the bitriazolyl motif for the observed antiviral activity.
authors.affiliation: State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
authors.forename: Menghua
authors.initials: M
authors.lastname: Wang
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Zhu
authors.forename: Zhijin
authors.initials: Z
authors.lastname: Fan
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Fu
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yao
authors.forename: Alain
authors.initials: A
authors.lastname: Maggiani
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Fanqi
authors.initials: F
authors.lastname: Qu
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D019810:Sodium Azide / Q000737:chemistry; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014230:Triazoles / Q000737:chemistry
chemical_list: D000480:Alkynes; D000998:Antiviral Agents; D009705:Nucleosides; D014230:Triazoles; D019810:Sodium Azide