title: The influence of surface properties of plasma-etched polydimethylsiloxane (PDMS) on cell growth and morphology.
abstract: Polydimethylsiloxane (PDMS) or silicone rubber is a widely used implant material. Approaches to promote tissue integration to PDMS are desirable to avoid clinical problems associated with sliding and friction between tissue and implant. Plasma-etching is a useful way to control cell behavior on PDMS without additional coatings. In this work, different plasma processing conditions were used to modify the surface properties of PDMS substrates. Surface nanotopography and wettability were measured to study their effect on in vitro growth and morphology of fibroblasts. While fluorinated plasma treatments produced nanorough hydrophobic and superhydrophobic surfaces that had negative or little influences on cellular behavior, water vapor/oxygen plasma produced smooth hydrophillic surfaces that enhanced cell growth.
authors.affiliation: Department of Health Science and Technology, Aalborg University, Denmark. cpennisi@hst.aau.dk
authors.forename: Cristian P
authors.initials: CP
authors.lastname: Pennisi
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zachar
authors.forename: Leonid
authors.initials: L
authors.lastname: Gurevich
authors.forename: Andrei
authors.initials: A
authors.lastname: Patriciu
authors.forename: Johannes J
authors.initials: JJ
authors.lastname: Struijk
mesh_terms: D002455:Cell Division; D002478:Cells, Cultured; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D006801:Humans; D018625:Microscopy, Atomic Force; D013499:Surface Properties; D017155:Wettability
chemical_list: D004129:Dimethylpolysiloxanes; C013830:baysilon