title: Nutritional influence on epigenetics and effects on longevity.
abstract: OBJECTIVE
  This review synthesizes recently published information regarding nutrition and its impact upon epigenetically mediated mechanisms involved in longevity and aging.
  
  
  RESULTS
  Recent studies enriched considerably our understanding of the relationship between aging and gene-nutrient interactions that continuously shape our phenotype. Epigenetic mechanisms play an important role in mediating between the nutrient inputs and the ensuing phenotypic changes throughout our entire life and seem to be responsible, in part, for the biological changes that occur during aging. Less is known about the epigenetic role that nutrients have in directly influencing longevity and aging. However, recent studies clearly indicated that because nutrition modulates epigenetic events associated with various diseases (e.g., cancer, obesity, and diabetes), there is at least an indirect epigenetic link between nutrition and longevity and, therefore, biologic plausibility to hypothesize the epigenetic role of nutrition in altering longevity. Apart from limited human studies, promising animal studies brought us much closer to understanding how nutrition could have such an impact upon longevity and aging.
  
  
  CONCLUSIONS
  Complex epigenetic mechanisms are involved in aging and longevity, directly or indirectly via disease mechanisms. Nutrition has a strong impact upon epigenetic processes and, therefore, holds promise in having important roles in regulating longevity and aging.
authors.affiliation: UNC Nutrition Research Institute, Kannapolis, North Carolina, USA. Mihai_Niculescu@unc.edu
authors.forename: Mihai D
authors.initials: MD
authors.lastname: Niculescu
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Lupu
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D004032:Diet; D044127:Epigenesis, Genetic; D006801:Humans; D008136:Longevity / Q000235:genetics*; D054647:Nutrigenomics; D010641:Phenotype