title: [A retrospective survey on allergic reactions by oxaliplatin].
abstract: Fifty-six patients treated with oxaliplatin were examined in order to clarify the factors that influence the appearance of allergic reactions by oxaliplatin at Kyoto City Hospital between January 2009 and December 2009, retrospectively. The number of patients in allergic and non-allergic group was 10 and 46, respectively. Patients' characteristics, the presence of hepatic metastasis, hepatic failure and kidney failure, albumin and white blood cell counts were compared in both groups. In the allergic group, the rate of hepatic metastasis was significantly higher than that in the non-allergic group (p=0.011). In conclusion, hepatic metastasis was suggested to be a factor that causes allergic reactions after administration of oxaliplatin.
authors.affiliation: Dept. of Pharmacy, Kyoto City Hospital.
authors.forename: Shinji
authors.initials: S
authors.lastname: Honda
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kitada
authors.forename: Tohru
authors.initials: T
authors.lastname: Hashida
authors.forename: Fuminori
authors.initials: F
authors.lastname: Imagawa
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin