title: How ubiquitination and autophagy participate in the regulation of the cell response to bacterial infection.
abstract: Bacterial infection relies on the micro-organism's ability to orchestrate the host's cell signalling such that the immune response is not activated. Conversely, the host cell has dedicated signalling pathways for coping with intrusions by pathogens. The autophagy of foreign micro-organisms (known as xenophagy) has emerged as one of the most powerful of these pathways, although the triggering mode remains largely unknown. In the present paper, we discuss the role that certain post-translational modifications (primarily ubiquitination) may play in the activation of xenophagy and how some bacteria have evolved mechanisms to subvert or hijack this process. In particular, we address the role played by P62/SQSTM1 (sequestosome 1). Finally, we discuss how autophagy can be subverted to eliminate bacteria-induced danger signals.
authors.affiliation: Cellular Microbiology of Infectious Pathogens, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Lille, F-59019, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupont
authors.forename: Nassima
authors.initials: N
authors.lastname: Temime-Smaali
authors.forename: Frank
authors.initials: F
authors.lastname: Lafont
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D001343:Autophagy / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology* / Q000503:physiopathology; D054884:Host-Pathogen Interactions / Q000502:physiology; D006801:Humans; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D000071456:Sequestosome-1 Protein; D015398:Signal Transduction; D058207:Sumoylation / Q000502:physiology; D054875:Ubiquitination / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein