title: Ischemic index and neovascularization in central retinal vein occlusion.
abstract: OBJECTIVE
  To explore the association of angiographic nonperfusion with anterior segment and posterior segment neovascularization in central retinal vein occlusion (CRVO).
  
  
  METHODS
  An imaging database at one institution was searched for the diagnosis of central retinal vein occlusion. Ultra wide field fluorescein angiograms were graded for image quality, the presence of retinal neovascularization, and the quantity of nonperfusion; an ischemic index (ISI) was calculated. Charts were reviewed to exclude eyes with previous treatment and to determine which eyes had anterior segment or posterior segment neovascularization on the day of the angiogram. Time from onset to presentation could not accurately be ascertained.
  
  
  RESULTS
  In a 39-month period, there were 69 eyes that met inclusion criteria. The mean ISI was 25% (SD, 26%; range, 0-100%), and 15 eyes (21%) with neovascularization had a mean ISI of 75% (range, 47-100%) compared with eyes without neovascularization that had an ISI of 6% (range, 0-43%). Ischemic index significantly correlated to neovascularization, and eyes that had evidence of neovascularization had an ISI >45% (P < 0.0001).
  
  
  CONCLUSIONS
  Ultra wide field fluorescein angiography provides visualization of nonperfusion in eyes with central retinal vein occlusion. Eyes with neovascularization on the day of the angiogram were found to have significantly larger areas of retinal nonperfusion compared with eyes without neovascularization. A prospective study is indicated to know if early treatment of peripheral retinal nonperfusion in CRVO improves outcomes.
authors.affiliation: Department of Ophthalmology, University of California, Los Angeles, CA, USA. irena.tsui@gmail.com
authors.forename: Irena
authors.initials: I
authors.lastname: Tsui
authors.forename: Andrew
authors.initials: A
authors.lastname: Kaines
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Havunjian
authors.forename: Sasha
authors.initials: S
authors.lastname: Hubschman
authors.forename: Gad
authors.initials: G
authors.lastname: Heilweil
authors.forename: Pradeep S
authors.initials: PS
authors.lastname: Prasad
authors.forename: Scott C N
authors.initials: SC
authors.lastname: Oliver
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Elena
authors.initials: E
authors.lastname: Bitrian
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hubschman
authors.forename: Thomas
authors.initials: T
authors.lastname: Friberg
authors.forename: Steven D
authors.initials: SD
authors.lastname: Schwartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment; D005123:Eye / Q000098:blood supply*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology*; D057972:Posterior Eye Segment; D015861:Retinal Neovascularization / Q000209:etiology*; D012170:Retinal Vein Occlusion / Q000150:complications*; D012171:Retinal Vessels; D055815:Young Adult