title: Infliximab as therapeutic option in steroid-refractory ulcerative colitis after kidney transplantation: case report.
abstract: In inflammatory bowel disease refractory to established therapies, treatment with biological agents such as monoclonal tumor necrosis factor-α antibodies is an established therapeutic option. However, application in renal allograft recipients is either not licensed or has not yet been systematically examined. Herein, we present 2 case reports of renal allograft recipients who had steroid-refractory ulcerative colitis who demonstrated improvement of symptoms after treatment with infliximab, without signs of effect on transplant function. In both patients, stool frequency decreased significantly. Colonoscopy controls and histologic examination after initiation of treatment revealed a state of remission. Renal function parameters and drug concentrations remained constant.
authors.affiliation: Department of Nephrology and Rheumatology, Georg-August-University, Göttingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Temme
authors.forename: M
authors.initials: M
authors.lastname: Koziolek
authors.forename: C
authors.initials: C
authors.lastname: Bramlage
authors.forename: I M
authors.initials: IM
authors.lastname: Schaefer
authors.forename: L
authors.initials: L
authors.lastname: Füzesi
authors.forename: G
authors.initials: G
authors.lastname: Ramadori
authors.forename: G A
authors.initials: GA
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Schwörer
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003113:Colonoscopy; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000069285:Infliximab; D007674:Kidney Diseases / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D013256:Steroids / Q000627:therapeutic use*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D013256:Steroids; D000069285:Infliximab