title: Synthesis and characterization of graft copolymer of chitosan and polyethylene glycol.
abstract: MPEG was modified with 1,1'-carbonyldiimidazole, then the activated MPEG reacted with primary amino groups of chitosan. Synthesize the graft copolymer of chitosan and polyethylene glycol in two steps. The structure of the copolymer was characterized by FT-IR and 1H-NMR. It agrees with the PEG content of classical stealth nanoparticles materials. The X-ray diffraction and DSC analysis proved that the crystallinity of the copolymer increased. It is a promising material for the stealth nanoparticles. It is a potential new carrier for the drug delivery systems of long-circulation and solid carcinoma.
authors.affiliation: Chengdu Medical College, West China Hospital, Sichuan University, Chengdu, 610083, Sichuan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Zang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Xu
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhong
authors.forename: Wang
authors.initials: W
authors.lastname: Zan
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
mesh_terms: D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D011108:Polymers; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D048271:Chitosan