title: [Analysis of four patients with advanced gastric cancer undergoing gastrectomy after pre-operative combination chemotherapy using docetaxel, cisplatin and S-1].
abstract: We analyzed the clinical efficacy of pre-operative combination chemotherapy using docetaxel, cisplatin and S-1 for advanced gastric cancer. Four patients were enrolled and staging laparoscopy was performed. Patients received intravenous docetaxel and cisplatin (35 mg/m2) on day 1 and 15, and oral S-1 80 mg/m2 on day 1-14 every 4 weeks. Two patients received two courses of chemotherapy and two patients received three courses of chemotherapy. Neutropenia of more than grade 3 was found in 3 cases. All cases were PR on preoperative imaging. Curative operation was performed on three cases. Histological anti-tumor effect was judged to be grade 2 in 1 case and grade 1a in 3 cases. In the postoperative period, all patients received S-1-based adjuvant chemotherapy. The combination chemotherapy using docetaxel, cisplatin and S-1 plus operation was a candidate for the standard treatment strategy for advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Hiratsuka City Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagase
authors.forename: Toshio
authors.initials: T
authors.lastname: Kanai
authors.forename: Motohito
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kumamoto
authors.forename: Syun
authors.initials: S
authors.lastname: Imai
authors.forename: Osamu
authors.initials: O
authors.lastname: Wada
authors.forename: Tomo
authors.initials: T
authors.lastname: Honda
authors.forename: Go
authors.initials: G
authors.lastname: Hoshino
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Atsukawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakaguchi
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Shiba
authors.forename: Takashi
authors.initials: T
authors.lastname: Nonaka
authors.forename: Kento
authors.initials: K
authors.lastname: Imajyo
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000628:therapy*; D043823:Taxoids / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid; D002945:Cisplatin