title: Smart hydrogel based microsensing platform for continuous glucose monitoring.
abstract: In this paper, we present preliminary results showing the response of glucose-sensitive hydrogels, confined in micro-pressure sensors, to the changes in environmental glucose concentration. The glucose concentrations were incrementally varied between 20 and 0mM in 0.15M PBS solution at 7.4 pH and bovine serum at 7.4 pH at room temperature and response of the sensor was recorded. The micro sensors demonstrate a response time of 10 minutes in both PBS and serum. Tissue response after 55 days of subcutaneous implantation of a EtO sterilized sensor in mice is presented. The preliminary analysis of the surrounding tissue shows inflammation which is believed not to interfere with the sensor performance.
authors.affiliation: Department of Electrical and Computer Engineering at the University of Utah, Salt Lake City, UT 84112, USA. p.tathireddy@utah.edu
authors.forename: Prashant
authors.initials: P
authors.lastname: Tathireddy
authors.forename: Mahender
authors.initials: M
authors.lastname: Avula
authors.forename: Genyao
authors.initials: G
authors.lastname: Lin
authors.forename: Seung Hei
authors.initials: SH
authors.lastname: Cho
authors.forename: Margarita
authors.initials: M
authors.lastname: Guenther
authors.forename: Volker
authors.initials: V
authors.lastname: Schulz
authors.forename: Gerald
authors.initials: G
authors.lastname: Gerlach
authors.forename: Jules J
authors.initials: JJ
authors.lastname: Magda
authors.forename: Florian
authors.initials: F
authors.lastname: Solzbacher
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D020100:Hydrogels / Q000737:chemistry*; D008365:Manometry / Q000295:instrumentation*; D051379:Mice; D008904:Miniaturization; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D014159:Transducers
chemical_list: D001786:Blood Glucose; D020100:Hydrogels