title: ODEs model of foreign body reaction around peripheral nerve implanted electrode.
abstract: The foreign body reaction that the neural tissue develops around an implanted electrode contributes to insulate the probe and enhances the electrical and mechanical mismatch. It is a complex interaction among cells and soluble mediators and the knowledge of this phenomenon can benefits of formal and analytical methods that characterize the mathematical models. This work offers a lumped component model, described by ordinary differential equations, that taking into account the main geometrical (size, shape, insertion angle) and chemical (coating surface) properties of the implant predict the thickness of the fibrotic capsule in a time frame when the reaction stabilizes. This tool allows to evaluate different hypothetical solutions for accounting the tissue-electrode mismatch.
authors.affiliation: Campus Biomedico Univ., Italian.
authors.forename: G
authors.initials: G
authors.lastname: Di Pino
authors.forename: D
authors.initials: D
authors.lastname: Formica
authors.forename: L
authors.initials: L
authors.lastname: Lonini
authors.forename: D
authors.initials: D
authors.lastname: Accoto
authors.forename: A
authors.initials: A
authors.lastname: Benvenuto
authors.forename: S
authors.initials: S
authors.lastname: Micera
authors.forename: P M
authors.initials: PM
authors.lastname: Rossini
authors.forename: E
authors.initials: E
authors.lastname: Guglielmelli
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004567:Electrodes, Implanted / Q000009:adverse effects*; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology*