title: Insulin analogues in the management of the pregnancy complicated by diabetes mellitus.
abstract: Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with insulin analogues in pregnancy has increased. The most studied, insulin lispro, has been shown to be a safe and clinically effective option in the treatment of the diabetic gravida. Studies of the other insulin analogues are limited, but promising. Further research is warranted to evaluate safety and efficacy of these analogues.
authors.affiliation: Department of Obstetrics and Gynecology, The Ohio State University, 395 West 12th Avenue, Columbus, OH 43210, USA. celeste.durnwald@osumc.edu
authors.forename: Celeste P
authors.initials: CP
authors.lastname: Durnwald
authors.forename: Mark B
authors.initials: MB
authors.lastname: Landon
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D061267:Insulin Aspart; D000069036:Insulin Glargine; D061268:Insulin Lispro; D049528:Insulin, Long-Acting; D011247:Pregnancy
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D061268:Insulin Lispro; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine; D061267:Insulin Aspart