title: The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
abstract: BACKGROUND
  We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors.
  
  
  OBJECTIVE
  In this research, we performed an in vivo/ex vivo study to evaluate the potential immunosuppressive effect of sertraline in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis.
  
  
  METHODS
  Mice (C57/bl EAE) were treated with sertraline (5 mg/kg) or dexamethasone (1 mg/kg) 7 days after EAE induction and then 3 times weekly (for 3 weeks).
  
  
  RESULTS
  Sertraline modestly improved the clinical score of EAE and attenuated the disease-induced weight loss. Sertraline also significantly decreased ex-vivo splenocyte viability, proliferation and secretion of pro-inflammatory cytokines in EAE mice.
  
  
  CONCLUSIONS
  We suggest that sertraline might be an add-on option for multiple sclerosis treatment.
authors.affiliation: Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel. michalt@post.tau.ac.il
authors.forename: Michal
authors.initials: M
authors.lastname: Taler
authors.forename: Irit
authors.initials: I
authors.lastname: Gil-Ad
authors.forename: Inna
authors.initials: I
authors.lastname: Korob
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis / Q000187:drug effects; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009103:Multiple Sclerosis / Q000276:immunology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D020280:Sertraline / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D016207:Cytokines; D007155:Immunologic Factors; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline