title: Correlation between child and parental perceptions of health-related quality of life in epilepsy using the PedsQL.v4.0 measurement model.
abstract: Health-related quality-of-life measures in childhood epilepsy are typically limited to a particular functional domain, specific age group, parent proxy-report, or child self-report. Generic health-related quality-of-life instruments in paediatric epilepsy comparing child self-reports with simultaneous parent proxy-reports have not been previously investigated. A previously validated generic questionnaire, the Pediatric Quality of Life version 4 (PedsQL.v4.0), was used to prospectively assess parental and child perceptions of health-related quality of life in 100 children with epilepsy. The correlation between child and parental health-related quality-of-life perceptions across all domains was excellent (p < 0.001) and both were significantly lower than those for healthy controls (p < 0.001). Parents' perceptions of their children's health-related quality of life were lower than those for other chronic illnesses (p < 0.001), especially for refractory epilepsy. The presence of neurological or psychiatric comorbidities also had an adverse impact on health-related quality of life. The PedsQL.v4.0 measures health-related quality of life from both the parent's and child's perspective. Ease of use makes this instrument attractive for routine clinical use.
authors.affiliation: Department of Neurology, Temple University Hospital, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Zulfi
authors.initials: Z
authors.lastname: Haneef
authors.forename: Mitzie L
authors.initials: ML
authors.lastname: Grant
authors.forename: Ignacio
authors.initials: I
authors.lastname: Valencia
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Hobdell
authors.forename: Sanjeev V
authors.initials: SV
authors.lastname: Kothare
authors.forename: Agustin
authors.initials: A
authors.lastname: Legido
authors.forename: Divya
authors.initials: D
authors.lastname: Khurana
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004827:Epilepsy / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D010290:Parents / Q000523:psychology*; D019727:Proxy / Q000523:psychology*; D011594:Psychometrics; D011788:Quality of Life; D012647:Self-Assessment; D012923:Social Class; D011795:Surveys and Questionnaires / Q000592:standards