title: An electronic DNA sensor chip using integrated capacitive read-out circuit.
abstract: This paper presents fully integrated label-free DNA recognition circuit based on capacitance measurement. A CMOS-based DNA sensor is implemented for the electrical detection of DNA hybridization. The proposed architecture detects the difference of capacitance through the integration of current mismatch of capacitance between reference electrodes functionalized with only single-stranded DNA and sensing electrodes bound with complementary DNA strands specifically. In addition, to minimize the effects of parallel resistance between electrodes and DNA layers, the compensation technique of leakage current through the use of constant current charging and discharging is implemented in the proposed detection circuit. The chip was fabricated in 0.35um 4-metal 2-poly CMOS process, and 16 × 8 sensing electrode arrays were fabricated by post-processing steps.
authors.affiliation: School of EECS, Korea Advanced Institution of Science and Technology (KAIST), Korea.
authors.forename: Byunghun
authors.initials: B
authors.lastname: Lee
authors.forename: Kang-Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Jeong-Oen
authors.initials: JO
authors.lastname: Lee
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Sohn
authors.forename: Suk-Hwan
authors.initials: SH
authors.lastname: Choi
authors.forename: Se-Won
authors.initials: SW
authors.lastname: Wang
authors.forename: Jun-Bo
authors.initials: JB
authors.lastname: Yoon
authors.forename: Gyu-Hyeong
authors.initials: GH
authors.lastname: Cho
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D004581:Electronics / Q000295:instrumentation / Q000379:methods*
chemical_list: D004247:DNA