title: [Clinical characteristics and gestational complications associated with acute hepatitis a in pregnancy].
abstract: OBJECTIVE
  Acute hepatitis A was recently significant increased among women with gestational age in Korea. However, the clinical course and gestational complications have not been fully elucidated in pregnant patients with acute hepatitis A. We evaluated the clinical impact of acute HAV infection in pregnancy.
  
  
  METHODS
  Twelve pregnant women out of 85 female patients with acute hepatitis A during 6 years were retrospectively reviewed.
  
  
  RESULTS
  The median age of the pregnant group was 26.5 years old. The number of patient with acute hepatitis A were 5 cases in the 1st trimester, 3 cases in the 2nd and 4 cases in the 3rd. 4 cases had significant gestational complications. One case experienced the abortion in 1st trimester and one fetal distress was noted in 3rd trimester. The latter case was delivered of a low birth weight infant (2,390 g) caused by premature rupture of membrane in 36 weeks of gestational age. Other two cases experienced premature contraction and they had been required tocolytic treatment. But, all mothers featured full recovery from HAV infection. Except one aborted fetus and one premature birth, Newborn babies were not affected by maternal hepatitis A.
  
  
  CONCLUSIONS
  Acute HAV infection during pregnancy may be associated with the risk of gestational complications. HAV serology and vaccination for women with gestation age should be considered at high prevalence area of acute hepatitis A.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Korea.
authors.forename: Ho Seong
authors.initials: HS
authors.lastname: Ryu
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Park
authors.forename: Sung Ryoun
authors.initials: SR
authors.lastname: Lim
authors.forename: Hyung Il
authors.initials: HI
authors.lastname: Kim
authors.forename: Won Ju
authors.initials: WJ
authors.lastname: Kee
authors.forename: Geum Soo
authors.initials: GS
authors.lastname: Lee
authors.forename: Gun Young
authors.initials: GY
authors.lastname: Hong
authors.forename: Sung Bum
authors.initials: SB
authors.lastname: Cho
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Choi
authors.forename: Jong Sun
authors.initials: JS
authors.lastname: Rew
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D005865:Gestational Age; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012189:Retrospective Studies; D012307:Risk Factors