title: [A case with local recurrence of rectal cancer that responded to S-1 and PSK with long-term complete response].
abstract: The patient was a 65-year-old male, who underwent low anterior resection for rectal cancer. The pathological diagnosis showed mucinous adenocarcinoma, pSS, and pN0. He complained of diarrhea and melena 4 months after the surgery. Abdominal computed tomography and colonofiberscopy showed a local recurrence of rectal cancer. Because the tumor was diagnosed as unresectable, combined chemotherapy of S-1 (100 mg/day, per os, 4 weeks of treatment and 2 weeks of rest) and PSK (3 g/day, per os, the same schedule as S-1) was started. After the 2 courses of chemotherapy, computed tomography and colonofiberscopy showed a complete disappearance of the tumor. The chemotherapy was continued until the 9th course and then stopped. Five years and 4 months since the induction of a complete response, the patient is still alive without disease recurrence. Combined chemotherapy of S-1 and PSK may be one of useful choices for recurrent colorectal cancer.
authors.affiliation: Coloproctology Center, Tohoku Rosai Hospital.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kakita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Funayama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Tokumura
authors.forename: Takashi
authors.initials: T
authors.lastname: Toshima
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Musya
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsumura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sasaki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yasumoto
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy*; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D010094:Oxonic Acid / Q000008:administration & dosage; D011509:Proteoglycans / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011509:Proteoglycans; C079198:S 1 (combination); D005641:Tegafur; C010770:polysaccharide-K; D010094:Oxonic Acid