title: Production of magnetic multilamellar liposomes as highly T2-efficient MRI contrast agents.
abstract: Lipid-based multilamellar vesicles loaded with aminosilane-modified maghemite nanoparticles (a-MNPs), also called magnetonions (MO), were analyzed for their magnetic resonance imaging (MRI) contrast agent properties. They were shown to be better T(2)-MRI contrast agents than commercial contrast agents and other reported liposome-based contrast agents as shown by their higher value of relaxivity ratio (r(2)/r(1) = 17), although a lower magnetic field intensity was used (0.2 T). Their high efficiency was explained by the aggregation of a-MNPs in between multilamellar vesicles, bilayers induced by MO preparation, and evidenced by cryo-TEM imaging. Magnetonions are then a promising platform for diagnosis and therapy.
  
  
  BACKGROUND
  In this study, magnetonions (MO) are presented as a very potent T2 relaxation enhancing MRI contrast agents. Such agents may be used in cell labeling and molecular imaging applications.
authors.affiliation: Centre de Recherche Paul Pascal (CNRS, UPR8641) - Université Bordeaux, Pessac, France.
authors.forename: Marie-Edith
authors.initials: ME
authors.lastname: Meyre
authors.forename: Gérard
authors.initials: G
authors.lastname: Raffard
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Franconi
authors.forename: Etienne
authors.initials: E
authors.lastname: Duguet
authors.forename: Olivier
authors.initials: O
authors.lastname: Lambert
authors.forename: Chrystel
authors.initials: C
authors.lastname: Faure
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D020285:Cryoelectron Microscopy; D005290:Ferric Compounds / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D008081:Liposomes; C000499:ferric oxide