title: SUN N8075, a novel radical scavenger, protects against retinal cell death in mice.
abstract: In this study, we examined the effect of SUN N8075, a radical scavenger with neuroprotective properties, on murine retinal damage induced by intravitreous injection of N-methyl-d-aspartate (NMDA) or high-intraocular pressure (IOP). In both models, systemic administration of SUN N8075 decreased the cell loss in the ganglion cell layer (GCL) after retinal damage occurred. Moreover, SUN N8075 reduced the number of apoptotic cells and the expression of an oxidative stress marker in GCL in the NMDA model. These findings suggest that SUN N8075 has a neuroprotective effect against retinal damage, presumably via the radical scavenging effect.
authors.affiliation: Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Akane
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Shimazawa
authors.forename: Yuta
authors.initials: Y
authors.lastname: Inokuchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsuruma
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hara
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000814:Aniline Compounds / Q000627:therapeutic use*; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000627:therapeutic use; D020287:In Situ Nick-End Labeling / Q000379:methods; D051379:Mice; D016202:N-Methylaspartate / Q000633:toxicity; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009798:Ocular Hypertension / Q000150:complications; D010879:Piperazines / Q000627:therapeutic use*; D012160:Retina / Q000187:drug effects / Q000473:pathology*; D012164:Retinal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013997:Time Factors
chemical_list: D000814:Aniline Compounds; D018696:Neuroprotective Agents; D010879:Piperazines; C413884:SUN N8075; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine