title: Chlorpyrifos induced region specific vulnerability in rat CNS and modulation by age and cold stress: an interactive study.
abstract: Chlorpyrifos (CPF), an organophosphorus insecticide is known to cause ill health in non-target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-related differences and vulnerability in central nervous system of rats. The results indicated an interaction with age and cold exposure resulting in marked decreased activity levels of SOD (P < 0.05), CAT (P < 0.05), GPx (P < 0.05), GST (P < 0.05) followed by increased MDA (P < 0.05) and decreased GSH levels (P < 0.05). The ANOVA and Post-hoc analysis showed that antioxidant enzymes decreased significantly (P < 0.05) on CPF exposure. Moreover synergistic action of CPF and cold stress at 15°C caused higher inhibition on comparison with CPF and cold stress alone and together at 20°C indicating the extent of peroxidative damage in discrete regions of CNS. Further this study showed young individuals to be more sensitive than adults.
authors.affiliation: Department of Zoology, Bangalore University, Bangalore, India. pmbashabub@rediffmail.com
authors.forename: P Mahaboob
authors.initials: PM
authors.lastname: Basha
authors.forename: Annappa
authors.initials: A
authors.lastname: Poojary
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002490:Central Nervous System / Q000033:anatomy & histology* / Q000187:drug effects* / Q000378:metabolism; D004390:Chlorpyrifos / Q000494:pharmacology*; D003080:Cold Temperature; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007306:Insecticides / Q000494:pharmacology*; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D007306:Insecticides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione; D004390:Chlorpyrifos