title: Whole-brain perfusion measurement using 320-detector row computed tomography in patients with cerebrovascular steno-occlusive disease: comparison with 15O-positron emission tomography.
abstract: OBJECTIVE
  The 320-detector row computed tomography (CT) can provide whole-brain CT perfusion (CTP) maps with continuous angiographic images by performing a single dynamic scan. We investigated the reliability of CTP cerebral blood flow (CTP-CBF) with 320-detector row CT by comparing findings with O-positron emission tomography (PET-CBF).
  
  
  METHODS
  Whole-brain CTP and PET were performed in 10 patients with chronic unilateral steno-occlusive disease. We compared absolute and relative CBF values of bilateral middle cerebral artery territories between CTP and PET.
  
  
  RESULTS
  Although mean CTP-CBF values were approximately 30% lower than mean PET-CBF values, the mean ischemic-to-nonischemic CBF ratios of CTP and PET were almost identical (P = 0.804). Regression analysis showed a significant correlation between CTP-CBF and PET-CBF values for each patient (r = 0.52-0.85, P < 0.001).
  
  
  CONCLUSIONS
  Whole-brain CTP using 320-detector row CT is useful for evaluating the degree of ischemia for the entire brain with chronic cerebrovascular disease.
authors.affiliation: Department of Radiology, Research Institute of Brain and Blood Vessels - Akita, Senshu-kubota-machi, Akita, Japan. shino-y@akita-noken.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Masanobu
authors.initials: M
authors.lastname: Ibaraki
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ohmura
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sugawara
authors.forename: Hideto
authors.initials: H
authors.lastname: Toyoshima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakamura
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kinoshita
authors.forename: Toshibumi
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011857:Radiographic Image Interpretation, Computer-Assisted; D014057:Tomography, X-Ray Computed / Q000379:methods*