title: Controllable dual-release of dexamethasone and bovine serum albumin from PLGA/β-tricalcium phosphate composite scaffolds.
abstract: Localized dual-drug delivery from biodegradable scaffolds is an important strategy in tissue engineering. In this study, porous poly(L-lactide-co-glycolide) (PLGA)/β-tricalcium phosphate scaffolds containing both dexamethasone (Dex) and bovine serum albumin (BSA) were prepared by incorporating Dex-loaded and BSA-loaded microspheres into the scaffolds. PLGA microspheres containing Dex or BSA were prepared by spray-drying and double emulsion/solvent evaporation, respectively. In vitro release studies indicated that microspheres prepared from PLGA in 3:1 molar ratio of L-lactide/glycolide and 89.5 kDa relative molecular mass showed prolonged release profiles compared with those prepared from PLGA in 1:1 L-lactide/glycolide molar ratio and 30.5 kDa relative molecular mass. Additionally, introduction of poly(ethylene glycol) in the PLGA chain could improve the encapsulation efficiency and reduce the release rate. Based on the above results, controllable dual-release of Dex and BSA with relatively higher or lower release rate was achieved by incorporating Dex-loaded and BSA-loaded microspheres with different release profiles into the PLGA/β-tricalcium phosphate scaffolds.
authors.affiliation: School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, People's Republic of China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Yang
authors.forename: Gongwen
authors.initials: G
authors.lastname: Tang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xubo
authors.initials: X
authors.lastname: Yuan
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry*; D002417:Cattle; D003907:Dexamethasone / Q000737:chemistry*; D004343:Drug Implants / Q000737:chemistry*; D006801:Humans; D008863:Microspheres; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D023181:Antimicrobial Cationic Peptides; D004343:Drug Implants; C045866:peptide-Gly-Leu-amide; D012710:Serum Albumin, Bovine; D003907:Dexamethasone