title: [Clinical characteristics, progression and risk factors of geographic atrophy].
abstract: Geographic atrophy (GA) as the late stage manifestation of age-related macular degeneration (AMD) is a progressive disease process afflicting the retinal pigment epithelium, choriocapillaris and the outer neurosensory retina. GA represents a complex, multifactorial disease governed by the interdependence of genetic, endogenous and exogenous factors. Diagnosis and monitoring of GA progression is largely based on various retinal imaging modalities. After the breakthrough in the treatment of wet AMD GA represents a large clinical challenge. Recent studies have contributed to a better understanding of the pathophysiological pathways, natural history and predictive markers for progression.
authors.affiliation: Universitäts-Augenklinik Bonn, Ernst-Abbe-Strasse 2, Bonn, Deutschland. christian.brinkmann@ukb.uni-bonn.de
authors.forename: C K
authors.initials: CK
authors.lastname: Brinkmann
authors.forename: C
authors.initials: C
authors.lastname: Adrion
authors.forename: U
authors.initials: U
authors.lastname: Mansmann
authors.forename: S
authors.initials: S
authors.lastname: Schmitz-Valckenberg
authors.forename: F G
authors.initials: FG
authors.lastname: Holz
mesh_terms: D000368:Aged; D001284:Atrophy; D002387:Cataract Extraction; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D018450:Disease Progression; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D057092:Geographic Atrophy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors; D014787:Vision Tests