title: C-type lectins, fungi and Th17 responses.
abstract: Th17 cells are a recently discovered subset of T helper cells characterised by the release of IL-17, and are thought to be important for mobilization of immune responses against microbial pathogens, but which also contribute to the development of autoimmune diseases. The identification of C-type lectin receptors which are capable of regulating the balance between Th1 and Th17 responses has been of particular recent interest, which they control, in part, though the release of Th17 inducing cytokines. Many of these receptors recognise fungi, and other pathogens, and play key roles in driving the development of protective anti-microbial immunity. Here we will review the C-type lectins that have been linked to Th17 type responses and will briefly examine the role of Th17 responses in murine and human anti-fungal immunity.
authors.affiliation: Aberdeen Fungal Group, Section of Infection and Immunity, Institute of Medical Sciences, School of Medicine and Dentistry, University of Aberdeen, Aberdeen AB252ZD, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Vautier
authors.forename: Maria da Glória
authors.initials: Mda G
authors.lastname: Sousa
authors.forename: Gordon D
authors.initials: GD
authors.lastname: Brown
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D053468:CARD Signaling Adaptor Proteins / Q000172:deficiency / Q000502:physiology; D005658:Fungi / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D007589:Job Syndrome / Q000276:immunology; D037181:Lectins, C-Type / Q000276:immunology* / Q000502:physiology; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D009181:Mycoses / Q000276:immunology; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D051192:Receptors, Pattern Recognition / Q000502:physiology; D058504:Th17 Cells / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D000096927:AIRE Protein
chemical_list: D053468:CARD Signaling Adaptor Proteins; D020381:Interleukin-17; D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011956:Receptors, Cell Surface; D051192:Receptors, Pattern Recognition; D014157:Transcription Factors; D000096927:AIRE Protein; C505855:CARD9 protein, human; C543376:CLEC-1 protein, rat; C113583:Clecsf8 protein, mouse; C445340:dectin-2, mouse