title: The relationship between inflammation, platelet activation and antiplatelet resistance.
abstract: Even though there is a strong evidence suggestive of benefits and safety of dual (aspirin plus clopidogrel) antiplatelet therapy, decreased responsiveness or "resistance" to mono- and/or dual antiplatelet therapy has been described in association with an increased thrombotic risk. Various mechanisms contribute to antiplatelet resistance, with abundant production of inflammatory markers being of particular importance. The current review overviews implications of inflammation in antiplatelet resistance.
authors.affiliation: Ministry of Health Dişkapı Yildirim Beyazit Research and Educational Hospital, Department of Cardiology, 06110 Ankara, Turkey. sadik.acikel@tkd.org.tr
authors.forename: Sadik
authors.initials: S
authors.lastname: Acikel
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
mesh_terms: D004351:Drug Resistance; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy*; D015539:Platelet Activation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors