title: Photoinduced superoxide radical anion and singlet oxygen generation in the presence of novel selenadiazoloquinolones (an EPR Study).
abstract: Novel 7-substituted 6-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-h]quinoline (SeQ(1-6)) and 8-substituted 9-oxo-6,9-dihydro[1,2,5]selenadiazolo[3,4-f ]quinoline derivatives (SeQN(1-5)) with R(7), R(8) =H, COOC(2) H(5), COOCH(3), COOH, COCH(3) or CN were synthesized and their spectral characteristics were obtained by UV/Vis spectroscopy. Ultraviolet A photoexcitation of the selenadiazoloquinolones in dimethylsulfoxide or acetonitrile resulted in the formation of paramagnetic species coupled with molecular oxygen activation generating the superoxide radical anion or singlet oxygen, evidenced by electron paramagnetic resonance spectroscopy. The cytotoxic/photocytotoxic impact of selenadiazoloquinolones on murine and human cancer cell lines was demonstrated using the derivative SeQ5 (with R(7)=COCH(3)).
authors.affiliation: Faculty of Chemical and Food Technology, Institute of Physical Chemistry and Chemical Physics, Slovak University of Technology, Bratislava, Slovak Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Barbieriková
authors.forename: Maroš
authors.initials: M
authors.lastname: Bella
authors.forename: Juraj
authors.initials: J
authors.lastname: Kučerák
authors.forename: Viktor
authors.initials: V
authors.lastname: Milata
authors.forename: Soňa
authors.initials: S
authors.lastname: Jantová
authors.forename: Dana
authors.initials: D
authors.lastname: Dvoranová
authors.forename: Mária
authors.initials: M
authors.lastname: Veselá
authors.forename: Andrej
authors.initials: A
authors.lastname: Staško
authors.forename: Vlasta
authors.initials: V
authors.lastname: Brezová
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D051379:Mice; D015363:Quinolones / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D015363:Quinolones; D013481:Superoxides; D026082:Singlet Oxygen