title: Model-based optimal immunization for antibody production in birds.
abstract: A dynamic model of the immune response in poultry was developed in order to enhance antibody production. Efficient production of antibodies is very valuable for researchers and physicians since they are used for other molecules detection. Large amounts of poultry-based antibodies are found in birds' eggs. However, inoculation timetables are based on empirical data. A seven differential equation system represents cellular and molecular populations of the humoral immune response in poultry. Model parameters are presented and simulation results reflect the typical immune responses. Finally, a genetic algorithm was designed in order to optimize antibody production.
authors.affiliation: Department of Electrical Engineering, Universidad Nacional de Colombia, USA. faolarted@unal.edu.co
authors.forename: Andres
authors.initials: A
authors.lastname: Olarte
authors.forename: Carlos
authors.initials: C
authors.lastname: Clavijo
authors.forename: Hernando
authors.initials: H
authors.lastname: Diaz
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology*; D000941:Antigens / Q000008:administration & dosage* / Q000276:immunology*; D001717:Birds / Q000276:immunology*; D003198:Computer Simulation; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology*; D007114:Immunization / Q000379:methods*; D018448:Models, Immunological
chemical_list: D000941:Antigens