title: Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.
abstract: BACKGROUND
  AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight.
  
  
  RESULTS
  In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI = 18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ≥28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P = 0.022, OR = 0.775 95%CI = 0.623-0.963), but not in overweight subjects (P = 0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P = 0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI = P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses.
  
  
  CONCLUSIONS
  The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
authors.forename: Hairu
authors.initials: H
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.forename: Weiguang
authors.initials: W
authors.lastname: Zhu
authors.forename: Jin
authors.initials: J
authors.lastname: Shen
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Shi
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Qihui
authors.initials: Q
authors.lastname: Zhao
authors.forename: Chuan
authors.initials: C
authors.lastname: Ni
authors.forename: Yaochu
authors.initials: Y
authors.lastname: Xu
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Chong
authors.initials: C
authors.lastname: Shen
authors.forename: Harvest F
authors.initials: HF
authors.lastname: Gu
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007527:Isoenzymes; D000262:Adenylyl Cyclases