title: [A case of recurrent invasive thymic cancer showing a stable disease to carboplatin plus paclitaxel].
abstract: A 56-year-old man was admitted to our hospital because of increasing chest discomfort and abnormal chest shadow. Computed tomography (CT) of the chest revealed an anterior mediastinal mass, pleural dissemination and lung metastasis. Percutaneus needle biopsy guided by CT showed that the mass was advanced thymic cancer (stage IV b according to the classification proposed by Masaoka). After failure of combination chemotherapy of cisplatin, vincristine, doxorubicin and etoposide (CODE), he received 4 cycles of carboplatin plus paclitaxel and then achieved confirmed stable disease. In terms of toxicity profile, grade 4 anemia, grade 2 leucopenia and neutropenia were observed, and particularly non-severe toxicity was not observed in terms of non-hematologic toxicity. Carboplatin plus paclitaxel can be an active agent against pretreated thymic cancer.
authors.affiliation: Dept. of Respiratory Medicine, Kitasato University School of Medicine.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Igawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Makita
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Iida
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Maki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Sakiko
authors.initials: S
authors.lastname: Otani
authors.forename: Nobuatsu
authors.initials: N
authors.lastname: Hayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Takakura
authors.forename: Ken
authors.initials: K
authors.lastname: Katono
authors.forename: Sayaka
authors.initials: S
authors.lastname: Onoda
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Masuda
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D013953:Thymus Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D016190:Carboplatin; D017239:Paclitaxel