title: Therapeutic molecular targets in human chondrosarcoma.
abstract: Chondrosarcomas are malignant cartilage tumours. They are poorly responsive to chemotherapy and radiotherapy. Treatment is usually limited to surgical resection; however, survival of patients with high-grade chondrosarcoma is poor, even with wide surgical resection. Induction of apoptosis in chondrosarcoma cells, either directly or by enhancement of the response to chemotherapeutic drugs and radiation, may be a route by which outcome can be improved. In this article, we review potential molecular targets that regulate chondrocyte apoptosis and discuss the experimental evidence for their utility.
authors.affiliation: Osteoarticular Research Group, Centre for Molecular Medicine, University of Edinburgh, Edinburgh, UK. N.S.M.Jamil@sms.ed.ac.uk
authors.forename: Nuor
authors.initials: N
authors.lastname: Jamil
authors.forename: Sarah
authors.initials: S
authors.lastname: Howie
authors.forename: Donald M
authors.initials: DM
authors.lastname: Salter
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002813:Chondrosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents