title: [Which clinical symptoms suggest distinct autoantibody measurements?].
abstract: The detection of autoantibodies is an important cornerstone in the diagnosis of systemic autoimmune disorders such as autoimmune connectivitides and small vessel vasculitides. Antinuclear antibodies (ANAs ) and antineutrophil cytoplasmic antibodies (c+p-ANCAs) are appropriate diagnostic screening tools for autoimmune connectivitides and small vessel vasculitides. For economic and intellectual/didactic reasons more extensive autoantibody diagnostics should be performed only in particular situations when patients history and clinical exam lead to strong diagnostic suspicion.
authors.affiliation: Universitätsklinik für Rheumatologie, Klinische Immunologie und Allergologie, Inselspital Bern. michael.seitz@insel.ch
authors.forename: Michael
authors.initials: M
authors.lastname: Seitz
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis / Q000276:immunology; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology*; D003240:Connective Tissue Diseases / Q000175:diagnosis* / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D008403:Mass Screening; D011237:Predictive Value of Tests; D056647:Systemic Vasculitis / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D001323:Autoantibodies