title: CD24 gene exon 2 dimorphism does not affect disease susceptibility in Japanese sarcoidosis patients.
abstract: BACKGROUND
  CD24 proteins are expressed on several inflammatory cells, and play an important role for the T-cell activation.
  
  
  OBJECTIVE
  The aim of this study is to investigate the relationship of a CD24 gene polymorphism to disease susceptibility or clinical findings including bronchoalveolar lavage (BAL) cell profiles in Japanese sarcoidosis patients.
  
  
  METHODS
  A previously reported functional single nucleotide polymorphism (SNP) of CD24 gene exon 2 was examined in 186 Japanese sarcoidosis patients and 146 sex and age-matched healthy controls using restriction fragment length polymorphism method. The distribution of genotypes was compared between the two groups. The association between genotypes or alleles and clinical features or BAL cell profiles was also examined.
  
  
  RESULTS
  There were no significant differences in the distribution of genotypes or allele frequencies between sarcoidosis and controls. There were also no significant differences in clinical features or BAL cell profiles among patients with different genotypes of CD24.
  
  
  CONCLUSIONS
  There was no relationship between a CD24 exon 2 SNP and disease susceptibility or clinical findings in Japanese sarcoidosis patients.
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tanizawda
authors.forename: T
authors.initials: T
authors.lastname: Handa
authors.forename: S
authors.initials: S
authors.lastname: Naga
authors.forename: E Y
authors.initials: EY
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Aihara
authors.forename: T
authors.initials: T
authors.lastname: Izumi
authors.forename: M
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D001999:Bronchoscopy; D051927:CD24 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012507:Sarcoidosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human