title: Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication.
abstract: Triterpene derivatives were analyzed for anti-HIV-1 activity and for cellular toxicity. Betulinic aldehyde, betulinic nitrile, and morolic acid derivatives were identified to have anti-HIV-1 activity. These derivatives inhibit a late step in virus replication, likely virus maturation.
authors.affiliation: University of Minnesota, Institute for Molecular Virology, 18-242 Moos Tower, 525 Delaware St SE, Minneapolis, MN 55455, United States.
authors.forename: Casey R
authors.initials: CR
authors.lastname: Dorr
authors.forename: Sergiy
authors.initials: S
authors.lastname: Yemets
authors.forename: Oksana
authors.initials: O
authors.lastname: Kolomitsyna
authors.forename: Pavel
authors.initials: P
authors.lastname: Krasutsky
authors.forename: Louis M
authors.initials: LM
authors.lastname: Mansky
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D014315:Triterpenes