title: DIMA 3.0: Domain Interaction Map.
abstract: Domain Interaction MAp (DIMA, available at http://webclu.bio.wzw.tum.de/dima) is a database of predicted and known interactions between protein domains. It integrates 5807 structurally known interactions imported from the iPfam and 3did databases and 46,900 domain interactions predicted by four computational methods: domain phylogenetic profiling, domain pair exclusion algorithm correlated mutations and domain interaction prediction in a discriminative way. Additionally predictions are filtered to exclude those domain pairs that are reported as non-interacting by the Negatome database. The DIMA Web site allows to calculate domain interaction networks either for a domain of interest or for entire organisms, and to explore them interactively using the Flash-based Cytoscape Web software.
authors.affiliation: Department of Genome Oriented Bioinformatics, Technische Universität München, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany.
authors.forename: Qibin
authors.initials: Q
authors.lastname: Luo
authors.forename: Philipp
authors.initials: P
authors.lastname: Pagel
authors.forename: Baiba
authors.initials: B
authors.lastname: Vilne
authors.forename: Dmitrij
authors.initials: D
authors.lastname: Frishman
mesh_terms: D030562:Databases, Protein; D009154:Mutation; D054730:Protein Interaction Domains and Motifs / Q000235:genetics; D025941:Protein Interaction Mapping / Q000379:methods*; D014584:User-Computer Interface