title: A novel method to assess the effect of uterine senescence by comparing pregnancy outcome in younger donors vs older recipients who are sharing a common pool of oocytes.
abstract: OBJECTIVE
  To evaluate uterine senescence by comparing pregnancy rates in older recipients vs their younger donors who were actually trying to conceive themselves.
  
  
  METHODS
  A retrospective analysis comparing clinical and delivered pregnancy rates in all infertile donors < or = age 35 sharing their eggs with a recipient age > or = 40 over a 6-year time span. These parameters were also evaluated in the first frozen embryo transfer from these couples (if they had one).
  
  
  RESULTS
  The clinical and delivered pregnancy rates were similar in younger donors vs older recipients following fresh embryo transfer. There was a non-significant trend for lower implantation rates in the younger donors. No differences were found when comparing frozen embryo transfers.
  
  
  CONCLUSIONS
  These data support conclusions that the uterus of women > or = 40 does not inhibit embryo implantation.
authors.affiliation: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: B
authors.initials: B
authors.lastname: Katsoff
authors.forename: T
authors.initials: T
authors.lastname: Jamison
authors.forename: J K
authors.initials: JK
authors.lastname: Choe
authors.forename: D
authors.initials: D
authors.lastname: Brasile
authors.forename: J
authors.initials: J
authors.lastname: Amui
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D018587:Oocyte Donation; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D014599:Uterus / Q000502:physiology*