title: In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron.
abstract: Bulk nanocrystalline pure iron rods were fabricated by the equal channel angular pressure (ECAP) technique up to eight passes. The microstructure and grain size distribution, natural immersion and electrochemical corrosion in simulated body fluid, cellular responses and hemocompatibility were investigated in this study. The results indicate that nanocrystalline pure iron after severe plastic deformation (SPD) would sustain durable span duration and exhibit much stronger corrosion resistance than that of the microcrystalline pure iron. The interaction of different cell lines reveals that the nanocrystalline pure iron stimulates better proliferation of fibroblast cells and preferable promotion of endothelialization, while inhibits effectively the viability of vascular smooth muscle cells (VSMCs). The burst of red cells and adhesion of the platelets were also substantially suppressed on contact with the nanocrystalline pure iron in blood circulation. A clear size-dependent behavior from the grain nature deduced by the gradual refinement microstructures was given and well-behaved in vitro biocompatibility of nanocrystalline pure iron was concluded.
authors.affiliation: State Key Laboratory for Turbulence and Complex System, Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871, People's Republic of China. niefeilong@pku.edu.cn
authors.forename: F L
authors.initials: FL
authors.lastname: Nie
authors.forename: Y F
authors.initials: YF
authors.lastname: Zheng
authors.forename: S C
authors.initials: SC
authors.lastname: Wei
authors.forename: C
authors.initials: C
authors.lastname: Hu
authors.forename: G
authors.initials: G
authors.lastname: Yang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000494:pharmacology; D001773:Blood Cells / Q000187:drug effects* / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003343:Corrosion; D003460:Crystallization / Q000379:methods; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size
chemical_list: D001672:Biocompatible Materials; D007501:Iron