title: [Genetic and molecular abnormalities of glioblastomas (GBM)].
abstract: This presentation reports a series of data dealing with recurrent genetic abnormalities and gene expression profiles that characterize primary glioblastomas and secondary glioblastomas resulting from the transformation of low grade tumors (grade II and III astrocytomas and oligodendrogliomas). The most recent aspects of the concept of tumor stem cells that may explain the relentless growth of GBM will be reported. Molecular features of tumor neoangiogenesis will be described. Epigenetic alterations and deregulation of gene expression by microRNAs (miRs) will be also included. Some aspects of tumor predisposition will be also discussed. Finally, a short description of exosomes as vectors of tumor information will be presented.
authors.affiliation: larsen.christian@orange.fr
authors.forename: C
authors.initials: C
authors.lastname: Larsen
mesh_terms: D001932:Brain Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002872:Chromosome Deletion; D019175:DNA Methylation / Q000235:genetics; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D057890:Epigenomics; D055354:Exosomes / Q000235:genetics*; D017353:Gene Deletion; D023281:Genomics / Q000379:methods; D005909:Glioblastoma / Q000098:blood supply / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006657:Histones / Q000235:genetics; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D006657:Histones; D035683:MicroRNAs; D025521:Tumor Suppressor Proteins; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D045643:DNA Repair Enzymes