title: ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation.
abstract: Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Sang Gyun
authors.initials: SG
authors.lastname: Kim
authors.forename: Andrew Y
authors.initials: AY
authors.lastname: Choo
authors.forename: John
authors.initials: J
authors.lastname: Blenis