title: BISC: binary subcomplexes in proteins database.
abstract: Binary subcomplexes in proteins database (BISC) is a new protein-protein interaction (PPI) database linking up the two communities most active in their characterization: structural biology and functional genomics researchers. The BISC resource offers users (i) a structural perspective and related information about binary subcomplexes (i.e. physical direct interactions between proteins) that are either structurally characterized or modellable entries in the main functional genomics PPI databases BioGRID, IntAct and HPRD; (ii) selected web services to further investigate the validity of postulated PPI by inspection of their hypothetical modelled interfaces. Among other uses we envision that this resource can help identify possible false positive PPI in current database records. BISC is freely available at http://bisc.cse.ucsc.edu.
authors.affiliation: School of Biology, University of Edinburgh, Edinburgh EH9 3JJ, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Juettemann
authors.forename: Dietlind L
authors.initials: DL
authors.lastname: Gerloff
mesh_terms: D030541:Databases, Genetic; D030562:Databases, Protein; D023281:Genomics; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000235:genetics; D025941:Protein Interaction Mapping
chemical_list: D046912:Multiprotein Complexes