title: Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers-a two isotopes SPECT study.
abstract: OBJECTIVE
  Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability.
  
  
  METHODS
  Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [(99m)Tc] TRODAT and [(123)I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs).
  
  
  RESULTS
  LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT.
  
  
  CONCLUSIONS
  Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 70428, Taiwan, Republic of China. ivylee@mail.ncku.edu.tw
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
authors.forename: Hui Chun
authors.initials: HC
authors.lastname: Huang
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.forename: Nan-Tsing
authors.initials: NT
authors.lastname: Chiu
authors.forename: Wei Jen
authors.initials: WJ
authors.lastname: Yao
authors.forename: Shih-Hsien
authors.initials: SH
authors.lastname: Lin
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D001931:Brain Mapping; D002928:Cinanserin / Q000031:analogs & derivatives; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008144:Loudness Perception / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014326:Tropanes; D055815:Young Adult
chemical_list: C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1; D002928:Cinanserin