title: Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.
abstract: Genome-wide association studies have associated common variations at chromosomes 5p15 and 15q25 with lung cancer risk. The 5p15 locus has also been associated with increased bladder cancer risk in a recent report. The 15q25 locus has been associated with nicotine dependence and self-reported number of cigarettes smoked per day in some studies and it was proposed that its association with lung cancer may be mediated through differences in smoking behavior. Here, we investigated the roles of variations at 5p15 (rs401681, rs402710, rs2736098 and rs2736100) and 15q25 (rs1051730 and rs8034191) in bladder cancer etiology in two case-control studies conducted separately in Los Angeles County, CA, USA (498 cases and 588 controls) and in Shanghai, China (506 cases and 530 controls). We replicated the association between the 5p15 locus and bladder cancer among non-Hispanic whites (NHW) in Los Angeles [for rs2736100, per C allele odds ratio (OR) = 1.23; 95% confidence interval (CI), 1.02-1.48; P = 0.029] and among Chinese in Shanghai (OR = 1.22; 95% CI, 1.02-1.47; P = 0.033). Both rs1051730 and rs8034191 at 15q25 were rare among Chinese. Among NHW, a significant association was found between rs8034191 and bladder cancer which persisted after adjustment for cigarette smoking status, number of cigarettes smoked per day and number of years of smoking (per C allele OR = 1.26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk.
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-9175, USA. mgago@usc.edu
authors.forename: Manuela
authors.initials: M
authors.lastname: Gago-Dominguez
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Jiang
authors.forename: David V
authors.initials: DV
authors.lastname: Conti
authors.forename: Jose Esteban
authors.initials: JE
authors.lastname: Castelao
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Stern
authors.forename: Victoria K
authors.initials: VK
authors.lastname: Cortessis
authors.forename: Malcolm C
authors.initials: MC
authors.lastname: Pike
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yuan
authors.forename: David J
authors.initials: DJ
authors.lastname: Van Den Berg
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000235:genetics*