title: A study using irreversible electroporation to treat large, irregular tumors in a canine patient.
abstract: Irreversible electroporation (IRE) has shown promise for the therapeutic treatment of focal disease, including tumors. The effects of treatment are dependent on the electric field distribution, which may be predicted with numerical modeling. In order to improve the effectiveness and scope of IRE therapies, techniques must be developed for designing protocols capable of treating large and irregular tumors. We present the findings of a study designing an IRE treatment plan for a canine patient using medical imaging analysis and reconstruction, numerical modeling, and real-time electrode placement guidance. The executed plan was able to alleviate the patient's clinical symptoms without damaging any of the nearby sensitive tissues in a complex heterogeneous environment.
authors.affiliation: Bioelectromechanical Systems Lab in the Virginia Tech - Wake Forest School of Biomedical Engineering and Sciences at Virginia Tech, Blacksburg, VA 24060, USA. nealre@vt.edu
authors.forename: Robert E
authors.initials: RE
authors.lastname: Neal
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Garcia
authors.forename: John H
authors.initials: JH
authors.lastname: Rossmeisl
authors.forename: Rafael V
authors.initials: RV
authors.lastname: Davalos
mesh_terms: D000465:Algorithms; D000818:Animals; D001859:Bone Neoplasms / Q000628:therapy* / Q000662:veterinary; D003952:Diagnostic Imaging; D004285:Dogs; D018274:Electroporation / Q000379:methods*; D005269:Femur / Q000473:pathology; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008495:Medical Oncology / Q000379:methods; D008962:Models, Theoretical; D011788:Quality of Life; D012509:Sarcoma / Q000628:therapy* / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000379:methods