title: Treatment of Class II molar furcation involvement: meta-analyses of reentry results.
abstract: BACKGROUND
  Predictable regeneration of lost periodontal tissues in furcations is difficult to achieve. This paper investigates the efficacy of different treatment modalities for Class II molar furcations.
  
  
  METHODS
  Publications in English were searched using PubMed, Medline, and Cochrane Library databases combined with hand searching from January 1, 1966 to October 1, 2007. The search included randomized controlled human trials in molar Class II furcations with over 6 months of surgical reentry follow-up. Changes in vertical probing depths, vertical attachment levels, and vertical and horizontal bone levels were compared.
  
  
  RESULTS
  The search identified 801 articles of which 34 of 108 randomized clinical trials met the criteria. Thirteen trials had test and control arms allowing three meta-analyses: 1) five comparing non-resorbable versus resorbable membranes, 2) five comparing non-resorbable membranes versus open flap debridement and 3) three comparing resorbable membranes versus open flap debridement. There was significant improvement for resorbable versus non-resorbable membranes mainly in vertical bone fill (0.77 ± 0.33 mm; [95% CI; 0.13, 1.41]). Non-resorbable membranes showed significant improvement in vertical probing reduction (0.75 ± 0.31 mm; [95% CI; 0.14, 1.35]), attachment gain (1.41 ± 0.46 mm; [95% CI; 0.50, 2.31]), horizontal bone fill (1.16 ± 0.29 mm; [95% CI; 0.59, 1.73]), and vertical bone fill (0.58 ± 0.11 mm; [95% CI; 0.35, 0.80]) over open flap debridement. Resorbable membranes showed significant improvement in vertical probing reduction (0.73 ± 0.16 mm; [95% CI; 0.42, 1.05]), attachment gain (0.88 ± 0.16 mm; [95% CI; 0.55, 1.20]), horizontal bone fill (0.98 ± 0.12 mm; [95% CI; 0.74, 1.21]) and vertical bone fill (0.78 ± 0.19 mm; [95% CI; 0.42, 1.15]) over open flap debridement.
  
  
  CONCLUSIONS
  Guided tissue regeneration with the use of resorbable membranes was superior to non-resorbable membranes in vertical bone fill. Both types of membranes were more effective than open flap debridement in reducing vertical probing depths and gaining vertical attachment levels and in gaining vertical and horizontal bone.
authors.affiliation: Postgraduate Periodontology Program, Boston University Institute of Dental Research and Education, Dubai, UAE. abkinaiadds@yahoo.com
authors.forename: Bassam Michael
authors.initials: BM
authors.lastname: Kinaia
authors.forename: Jacob
authors.initials: J
authors.lastname: Steiger
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Neely
authors.forename: Maanas
authors.initials: M
authors.lastname: Shah
authors.forename: Monish
authors.initials: M
authors.lastname: Bhola
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes; D017823:Furcation Defects / Q000145:classification / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D008963:Molar / Q000473:pathology; D053657:Platelet-Rich Plasma; D016032:Randomized Controlled Trials as Topic
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial