title: Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis.
abstract: OBJECTIVE
  A comparison of the clinical status and salivary MMP levels after SRP alone or with ozonotherapy in patients with aggressive and chronic periodontitis.
  
  
  METHODS
  The study was performed in 52 generally healthy subjects with chronic or aggressive periodontitis. Group CP-S consisted of 12 patients with chronic periodontitis, who underwent scaling and root planing (SRP). In group CP-O there were 25 patients with chronic periodontitis who additionaly to SRP underwent ozonotherapy. The same therapy was performed in group AP, containing 15 patients with aggressive periodontitis. Plaque index, approximal plaque index, bleeding on probing, sulcus bleeding index, probing pocket depth and clinical attachment loss were measured at baseline, at two weeks and two months post-therapy. The levels of MMP-1, MMP-8 and MMP-9 were estimated in non-stimulated saliva with an ELISA method.
  
  
  RESULTS
  All the clinical parameters assessed in the study groups were reduced after treatment. SRP with additional ozonotherapy provided an increase in MMP levels in patients with chronic periodontitis and a reduction in MMP levels in patients with aggressive periodontitis.
  
  
  CONCLUSIONS
  SRP followed by ozonotherapy does not lead to further improvement in clinical periodontal parameters in patients with AP and CP.
authors.affiliation: Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, Poland. annaskurska@wp.pl
authors.forename: A
authors.initials: A
authors.lastname: Skurska
authors.forename: M D
authors.initials: MD
authors.lastname: Pietruska
authors.forename: A
authors.initials: A
authors.lastname: Paniczko-Drężek
authors.forename: E
authors.initials: E
authors.lastname: Dolińska
authors.forename: B
authors.initials: B
authors.lastname: Zelazowska-Rutkowska
authors.forename: J
authors.initials: J
authors.lastname: Zak
authors.forename: J
authors.initials: J
authors.lastname: Pietruski
authors.forename: R
authors.initials: R
authors.lastname: Milewski
authors.forename: J
authors.initials: J
authors.lastname: Wysocka
mesh_terms: D000328:Adult; D000368:Aged; D010520:Aggressive Periodontitis / Q000188:drug therapy* / Q000201:enzymology*; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000201:enzymology*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008875:Middle Aged; D010083:Oxidants, Photochemical / Q000627:therapeutic use*; D010126:Ozone / Q000627:therapeutic use*; D016745:Root Planing; D012463:Saliva / Q000201:enzymology
chemical_list: D010083:Oxidants, Photochemical; D010126:Ozone; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1