title: CXCL12 and CXCR4 in bone marrow physiology.
abstract: This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival or apoptosis. The selective signaling pathways that mediate these varied outcomes are summarized briefly. The CXCL12/CXCR4 pair is crucially involved in homing and repopulation of HSCs in the specific BM niches. Mechanisms of HSC mobilization to the peripheral circulation in response to physiological requests and therapeutic stimulations, as well as recent data on the novel receptor for CXCL12, CXCR7, are reviewed.
authors.affiliation: CRICM / INSERM-UPMC, UMRS 975/CNRS UMR 7225, Faculté de Médecine Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, 105 bd. de l'Hôpital, 75634 Paris, France. natalia.moll@upmc.fr
authors.forename: Natalia M
authors.initials: NM
authors.lastname: Moll
authors.forename: Richard M
authors.initials: RM
authors.lastname: Ransohoff
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D054377:Chemokine CXCL12 / Q000502:physiology; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D051379:Mice; D054387:Receptors, CXCR / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: C501896:ACKR3 protein, human; D054377:Chemokine CXCL12; D047908:Intracellular Signaling Peptides and Proteins; D054387:Receptors, CXCR; D019718:Receptors, CXCR4