title: 64-Slice multidetector row CT angiography of the abdomen: comparison of low versus high concentration iodinated contrast media in a porcine model.
abstract: OBJECTIVE
  In this study we aimed to assess the image quality and degree of vascular enhancement using low-concentration contrast media (LCCM) (300 mg I ml(-1)) and high-concentration contrast media (HCCM) (370 mg I ml(-1)) on 64-slice multidetector row CT (MDCT) abdominal CT angiography (CTA). In addition, we aimed to study the feasibility of using HCCM with a reduced total iodine dose.
  
  
  METHODS
  CTA of the abdomen on a 64-slice MDCT was performed on 15 anaesthetised pigs. Study pigs were divided into three groups of five each based on the iodine concentration and dose received: Group A (LCCM; 300 mg I ml(-1)), Group B (HCCM; 370 mg I ml(-1)) and Group C HCCM with 20% less iodine dose. The total iodine injected was kept constant (600 mg kg(-1)) in Groups A and B. Qualitative and quantitative analyses were performed to study and compare each group for image quality, visibility of the branch order of the superior mesenteric artery (SMA), artefacts, degree of enhancement in the aorta and main stem arteries and uniformity of enhancement in the aorta. Groups were compared using the analysis of variance test.
  
  
  RESULTS
  The image quality of 64-slice MDCT angiography was excellent with a mean score of 4.63 and confident visualisation of the third to fifth order branches of the SMA in all groups. Group B demonstrated superior vascular enhancement, as compared with Groups A and C (p≤0.05). Uniform aortic enhancement was achieved with the use of LCCM and HCCM with 20% less iodine dose.
  
  
  CONCLUSIONS
  64-slice MDCT angiography of the abdomen was of excellent quality. HCCM improves contrast enhancement and overall CTA image quality and allows the iodine dose to be reduced.
authors.affiliation: Boston Medical Center, Department of Radiology, Boston, MA 02118, USA. Nagaraj.Holalkere@bmc.org
authors.forename: N-S
authors.initials: NS
authors.lastname: Holalkere
authors.forename: K
authors.initials: K
authors.lastname: Matthes
authors.forename: S P
authors.initials: SP
authors.lastname: Kalva
authors.forename: W R
authors.initials: WR
authors.lastname: Brugge
authors.forename: D V
authors.initials: DV
authors.lastname: Sahani
mesh_terms: D000704:Analysis of Variance; D000792:Angiography / Q000379:methods; D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007455:Iodine / Q000008:administration & dosage*; D008297:Male; D017538:Mesenteric Artery, Superior / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007455:Iodine