title: Central GLP-1 actions on energy metabolism.
abstract: Glucagon-like peptide 1 (GLP-1) is secreted mainly by the intestine in a nutrient-dependent manner and stimulates glucose-induced insulin secretion, inhibits gastric emptying, food intake, and glucagon secretion. All these beneficial effects make GLP-1 as a promising, and currently in the market, drug candidate for the treatment of type 2 diabetes. More recently, it has been also demonstrated that within the central nervous system, GLP-1 also exerts important metabolic actions inhibiting food intake, increasing insulin secretion, and modulating behavioral responses. In this review, we will focus on the metabolic actions and mechanisms of the central GLP-1 system: modulation of energy intake, glucose metabolism, and fatty acid metabolism.
authors.affiliation: Department of Physiology, School of Medicine, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruña, Spain.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Velásquez
authors.forename: Daniel
authors.initials: D
authors.lastname: Beiroa
authors.forename: María J
authors.initials: MJ
authors.lastname: Vázquez
authors.forename: Amparo
authors.initials: A
authors.lastname: Romero
authors.forename: Miguel
authors.initials: M
authors.lastname: López
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
authors.forename: Ruben
authors.initials: R
authors.lastname: Nogueiras
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans
chemical_list: D005227:Fatty Acids; D052216:Glucagon-Like Peptide 1; D005947:Glucose