title: Bipolar affective disorder, type II, apparently precipitated by donepezil.
abstract: There is considerable evidence that pro-cholinergic agents can cause depressed mood. However, there are also published case reports of a rare association between cholinesterase inhibitors and mood elevation in patients with pre-existing major functional psychiatric disorders, or organic disorders other than dementia. This report adds to the literature by describing a case of mood elevation in a patient without pre-existing psychiatric disorder.
authors.affiliation: Princess Margaret Hospital, Christchurch, New Zealand. chris.collins@cdhb.govt.nz
authors.forename: Chris
authors.initials: C
authors.lastname: Collins
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Copeland
authors.forename: Matthew
authors.initials: M
authors.lastname: Croucher
mesh_terms: D000368:Aged; D001714:Bipolar Disorder / Q000139:chemically induced*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D015140:Dementia, Vascular / Q000188:drug therapy; D000077265:Donepezil; D005260:Female; D006801:Humans; D007189:Indans / Q000009:adverse effects* / Q000627:therapeutic use; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil