title: NHC-catalyzed spiro bis-indane formation via domino Stetter-aldol-Michael and Stetter-aldol-aldol reactions.
abstract: Two novel domino NHC-catalyzed spirocyclizations are described herein, enabling the rapid construction of three new carbon-carbon bonds and a quaternary center with high diastereoselectivity. A variety of spiro bis-indane structures are assembled in a single step from simple o-phthaldialdehyde derivatives.
authors.affiliation: Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sánchez-Larios
authors.forename: Janice M
authors.initials: JM
authors.lastname: Holmes
authors.forename: Crystal L
authors.initials: CL
authors.lastname: Daschner
authors.forename: Michel
authors.initials: M
authors.lastname: Gravel
mesh_terms: D002384:Catalysis; D007189:Indans / Q000138:chemical synthesis*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*
chemical_list: D007189:Indans; D013141:Spiro Compounds