title: [Clinico-pathological evaluation of restrictive cardiomyopathy].
abstract: OBJECTIVE
  restrictive cardiomyopathy (RCM) is characterized by impairment of ventricular filling during diastole with preserved systolic function. The clinical and histopathological profile on endomyocardial biopsy of 25 consecutive patients with RCM was analyzed in this study.
  
  
  METHODS
  twenty-five patients with diagnosis of RCM and underwent endomyocardial biopsy (EMB) were enrolled in the study. The clinical characteristics, electrocardiogram, serum chemistry, right heart catheter and cardiac pathology results were obtained.
  
  
  RESULTS
  heart failure symptom was present in all 25 patients and left ventricular size and function were normal or near normal while serum brain natriuretic peptide (577 pg/ml) was moderately elevated. Right atrial and ventricular end-diastolic as well as pulmonary capillary wedge pressures derived from right heart catheter examination were increased. Amyloid deposition were evidenced in 16 and eosinophilic myocarditis in 2 patients upon pathological examination of EMB. In the remaining 7 patients, 3 were diagnosed idiopathic RCM, 2 were diagnosed as amyloidosis by biopsy from non-cardiac tissue and etiology remained unknown in 2 patients. Thus, conclusive diagnosis was made on EMB samples in 84% (21/25) patients of RCM.
  
  
  CONCLUSIONS
  RCM may result from various local and systemic disorders. EMB is helpful for identifying the underlying etiology.
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: TIAN
authors.forename: Yong
authors.initials: Y
authors.lastname: ZENG
authors.forename: Quan
authors.initials: Q
authors.lastname: FANG
authors.forename: Da-chun
authors.initials: DC
authors.lastname: ZHAO
authors.forename: Quan-cai
authors.initials: QC
authors.lastname: CUI
authors.forename: Kang-an
authors.initials: KA
authors.lastname: CHENG
authors.forename: Li-gang
authors.initials: LG
authors.lastname: FANG
authors.forename: Peng
authors.initials: P
authors.lastname: GAO
authors.forename: Zhong-wei
authors.initials: ZW
authors.lastname: CHENG
authors.forename: Xiu-chun
authors.initials: XC
authors.lastname: JIANG
authors.forename: Rong-liang
authors.initials: RL
authors.lastname: SUN
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000686:Amyloidosis; D001706:Biopsy; D002313:Cardiomyopathy, Restrictive / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011657:Pulmonary Eosinophilia; D055815:Young Adult