title: Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans.
abstract: The biological properties and possible pharmacological applications of benzo[kl]xanthene lignans, rare among natural products and synthetic compounds, are almost unexplored. In the present contribution, the possible interaction of six synthetic benzo[kl]xanthene lignans and the natural metabolite rufescidride with DNA has been investigated through a combined STD-NMR and molecular docking approach, paralleled by in vitro biological assays on their antiproliferative activity towards two different cancer cell lines: SW 480 and HepG2. Our data suggest that the benzo[kl]xanthene lignans are suitable lead compounds for the design of DNA selective ligands with potential antitumour properties.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084, Fisciano (SA), Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Di Micco
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mazué
authors.forename: Carmelo
authors.initials: C
authors.lastname: Daquino
authors.forename: Carmela
authors.initials: C
authors.lastname: Spatafora
authors.forename: Dominique
authors.initials: D
authors.lastname: Delmas
authors.forename: Norbert
authors.initials: N
authors.lastname: Latruffe
authors.forename: Corrado
authors.initials: C
authors.lastname: Tringali
authors.forename: Raffaele
authors.initials: R
authors.lastname: Riccio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bifulco
mesh_terms: D000969:Antinematodal Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000969:Antinematodal Agents; D017705:Lignans; D014966:Xanthenes; D004247:DNA