title: Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.
abstract: The synthesis and biological annotation of small molecules from underexplored chemical space will play a central role in the development of drugs for challenging targets currently being identified in frontier areas of biological research such as human genetics.
authors.affiliation: Chemical Biology Platform, Broad Institute, Cambridge, Massachusetts, USA. sivaram@broadinstitute.org
authors.forename: Sivaraman
authors.initials: S
authors.lastname: Dandapani
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Marcaurelle
mesh_terms: D002621:Chemistry / Q000639:trends; D015195:Drug Design; D055808:Drug Discovery / Q000639:trends*; D004353:Drug Evaluation, Preclinical; D054852:Small Molecule Libraries; D058615:Synthetic Biology / Q000639:trends*
chemical_list: D054852:Small Molecule Libraries