title: [The incidence of gastrointestinal bleeding, thromboembolic events, and gastrointestinal perforation in metastatic or unresectable gastric cancer during chemotherapy].
abstract: The incidence of gastrointestinal bleeding, thromboembolic events and gastrointestinal perforation during chemotherapy with metastatic or unresectable gastric cancer has been unknown. To clarify the incidence of these events, we reviewed the clinical records of our hospital.
  
  
  METHODS
  We investigated metastatic or unresectable gastric cancer patients who received chemotherapy during January 2002 to December 2006. Grade≥3 (CTCAE v3.0) adverse events from the first day of chemotherapy to 1 month after the last day of chemotherapy were investigated.
  
  
  RESULTS
  A total of 292 patients received chemotherapy. Patient characteristics were as follows: median age 63.5 years (range, 28 to 87); performance status 0/1/2/3: 129/129/31/3; male: female, 206:86, histopathological type intestinal/diffuse/unclassified-adenocarcinoma/others: 91/139/58/4. We found the incidence of Grade≥3 gastrointestinal bleeding in 7 patients (2.4%), thromboembolic events in 5 patients (1.7%) and gastrointestinal perforation in 3 patients (1.0%). Thromboembolic events in patients under 55 years of age were associated with a higher incidence (p=0. 0046).
  
  
  CONCLUSIONS
  The incidence was not so high as expected. We should be aware of the frequency of these toxicities in the treatment of gastric cancer.
authors.affiliation: The Cancer Institute Hospital of the Japanese Foundation For Cancer Research.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichimura
authors.forename: Keisho
authors.initials: K
authors.lastname: Chin
authors.forename: Kokoro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masato
authors.initials: M
authors.lastname: Osaka
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Kuboki
authors.forename: Mariko
authors.initials: M
authors.lastname: Ogura
authors.forename: Eiji
authors.initials: E
authors.lastname: Shinozaki
authors.forename: Mitsukuni
authors.initials: M
authors.lastname: Suenaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsuzaka
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Mizunuma
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Hatake
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy*; D013923:Thromboembolism / Q000139:chemically induced / Q000209:etiology*