title: [Efficacy of traditional therapy and chronotherapy using prestarium in elderly patients with polymorbid syndrome].
abstract: The aim of the work was to compare efficiency of traditional therapy with prestarium (tert-butylamine salt) and chronotherapy with prestarium A (arginine salt) in elderly patients with polymorbidity syndrome (diabetes mellitus, nephropathy, grade I-II chronic hepatic insufficiency). All patients underwent standard clinical and laboratory examination including measurement of glycemic profile, plasma urea, creatinine, K+ and Na+, AP monitoring, ECG, and echo-CG. The results suggest persistent hypotensive effect of prestarium and prestarium A within 4 days after the onset of therapy. However, in patients with a more severe disease, twice lower doses of prestarium A were needed to achieve positive effect and transform circadian AP rhythm from non-dipper to dipper pattern.
authors.forename: R M
authors.initials: RM
authors.lastname: Zaslavskaia
authors.forename: N D
authors.initials: ND
authors.lastname: Buniatian
authors.forename: S V
authors.initials: SV
authors.lastname: Sergeev
authors.forename: A M
authors.initials: AM
authors.lastname: Lukashev
authors.forename: O A
authors.initials: OA
authors.lastname: Lednev
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D055870:Drug Chronotherapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000008:administration & dosage / Q000627:therapeutic use*; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy; D013577:Syndrome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D020913:Perindopril