title: Synthesis and antifungal activity of some substituted phenothiazines and related compounds.
abstract: Several phenothiazines and related compounds were synthesized and their antifungal activity was evaluated in vitro. The results observed for α-chloro-N-acetyl phenothiazine led us to choose this compound as a lead in the search of antifungal agents.
authors.affiliation: Department of Pharmacology, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, CABA, Argentina.
authors.forename: Gabriela P
authors.initials: GP
authors.lastname: Sarmiento
authors.forename: Roxana G
authors.initials: RG
authors.lastname: Vitale
authors.forename: Javier
authors.initials: J
authors.lastname: Afeltra
authors.forename: Graciela Y
authors.initials: GY
authors.lastname: Moltrasio
authors.forename: Albertina G
authors.initials: AG
authors.lastname: Moglioni
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D010640:Phenothiazines; C031637:phenothiazine