title: How to quantitatively synthesize dynamic changes in arterial pressure from baroreflexly modulated ventricular and arterial properties.
abstract: Baroreflex regulates arterial pressure by modulating ventricular and vascular properties. We investigated if the framework of circulatory equilibrium that we developed previously (Am J Physiol 2004, 2005) by extending the classic Guyton's framework is capable of predicting baroreflex induced changes in arterial pressure. In animal experiments, we estimated open loop transfer functions of baroreflexly modulated ventricular and vascular properties, synthesized baroreflex induced dynamic changes in arterial pressure using the estimated transfer functions and compared the predicted responses with measured responses. We demonstrated that the predicted baroreflex induced changes in arterial pressure matched reasonable well with those measured. We conclude that the framework of circulatory equilibrium is generalizable under the condition where baroreflex dynamically changes arterial pressure.
authors.affiliation: Kyushu university, Fukuoka 8128582 Japan. tsaka@cardiol.med.kyushu-u.ac.jp
authors.forename: Takafumi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Murayama
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tobushi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tanaka
authors.forename: Takaki
authors.initials: T
authors.lastname: Tsutsumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D000465:Algorithms; D000818:Animals; D001158:Arteries / Q000473:pathology*; D017704:Baroreflex; D001698:Biomedical Engineering / Q000379:methods; D001794:Blood Pressure; D002302:Cardiac Output; D002339:Carotid Arteries / Q000503:physiopathology; D004285:Dogs; D006439:Hemodynamics; D010496:Pericardium / Q000473:pathology; D015203:Reproducibility of Results; D013599:Systole; D013997:Time Factors