title: High factor XI, recurrent pregnancy loss, enoxaparin.
abstract: Of the 149 women with 0 pregnancy losses, 7 (5%) had factor XI level ≥150% versus 5 of 31 (16%) women with recurrent pregnancy loss. Three of the 5 women with high factor XI and recurrent pregnancy loss, with 19 previous pregnancy losses and 0 live births, were given enoxaparin during 5 subsequent pregnancies, and had 6 term live births and 1 miscarriage.
authors.affiliation: Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA. glueckch@healthall.com
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Glueck
authors.forename: Joel
authors.initials: J
authors.lastname: Pranikoff
authors.forename: Naseer
authors.initials: N
authors.lastname: Khan
authors.forename: Kashif
authors.initials: K
authors.lastname: Riaz
authors.forename: Kirti
authors.initials: K
authors.lastname: Chavan
authors.forename: Pavithra
authors.initials: P
authors.lastname: Raj
authors.forename: Muhammad
authors.initials: M
authors.lastname: Umar
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D000925:Anticoagulants / Q000627:therapeutic use; D015331:Cohort Studies; D020964:Embryo Loss / Q000097:blood / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control; D017984:Enoxaparin / Q000008:administration & dosage / Q000627:therapeutic use*; D005172:Factor XI / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006720:Homozygote; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D020125:Mutation, Missense; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology; D018873:Pregnancy Rate; D015854:Up-Regulation
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D005172:Factor XI; D042965:Methylenetetrahydrofolate Reductase (NADPH2)