title: Is there any association between esophagogastric endoscopic findings and laryngeal cancer?
abstract: OBJECTIVE
  The aim of the study was to survey the association between prevalence of acid-related inflammation in the upper digestive tract and laryngeal cancer.
  
  
  METHODS
  A case-control study was done in an otolaryngology ward at an academic university. Totally, 65 patients with laryngeal cancer and 65 cancer-free matched controls underwent esophagogastroduodenoscopy, and endoscopic findings were collected.
  
  
  RESULTS
  In the case group, positive endoscopic findings were significantly higher than the control group (87.7% vs 58.5%; P < .001). Laryngeal cancer patients had erosive esophagitis, and gastritis ± other findings more than the control group (48 vs 29 cases) and the difference was statistically significant.
  
  
  CONCLUSIONS
  The difference between endoscopic findings in cases and controls was statistically significant. Severe inflammation and erosion existed in patients with laryngeal cancer that could be due to increased acid secretion. Our study supported the hypothesis that gastric acid and pepsin play a role in laryngeal cancer.
authors.affiliation: Department of Otorhinolaryngology, Semnan University of Medical Sciences, Iran.
authors.forename: Najmeh
authors.initials: N
authors.lastname: Doustmohammadian
authors.forename: Masoud
authors.initials: M
authors.lastname: Naderpour
authors.forename: Manochehr
authors.initials: M
authors.lastname: Khoshbaten
authors.forename: A'azam
authors.initials: A
authors.lastname: Doustmohammadian
mesh_terms: D017677:Age Distribution; D016022:Case-Control Studies; D015897:Comorbidity; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000453:epidemiology*; D004945:Esophagoscopy / Q000379:methods; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005756:Gastritis / Q000175:diagnosis / Q000453:epidemiology; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology*; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis / Q000453:epidemiology*; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D017678:Sex Distribution