title: The I222V neuraminidase mutation has a compensatory role in replication of an oseltamivir-resistant influenza virus A/H3N2 E119V mutant.
abstract: Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised patient. Based on plaque size, yield assays, and NA activity, the impaired viral fitness of the E119V mutant was partially restored by the I222V NA mutation.
authors.affiliation: Centre de Recherche en Infectiologie, Université Laval, 2705 Boul. Laurier, Québec City, Quebec G1V 4G2, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Simon
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Holder
authors.forename: Xavier
authors.initials: X
authors.lastname: Bouhy
authors.forename: Yacine
authors.initials: Y
authors.lastname: Abed
authors.forename: Catherine A A
authors.initials: CA
authors.lastname: Beauchemin
authors.forename: Guy
authors.initials: G
authors.lastname: Boivin
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D024882:Drug Resistance, Viral; D006801:Humans; D016867:Immunocompromised Host; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology*; D007251:Influenza, Human / Q000821:virology; D020125:Mutation, Missense; D009439:Neuraminidase / Q000235:genetics*; D053139:Oseltamivir / Q000494:pharmacology*; D013489:Suppression, Genetic; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000235:genetics*; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D014764:Viral Proteins; D053139:Oseltamivir; C487630:NA protein, influenza A virus; D009439:Neuraminidase