title: Strong exercise stress exacerbates dermatitis in atopic model mice, NC/Nga mice, while proper exercise reduces it.
abstract: Atopic dermatitis is well known to exacerbate by stress. How the influence of exercise stress on the skin symptoms in patients with atopic dermatitis has not been clarified. The purpose of our research is to investigate how different strength of exercise stress acts on atopic dermatitis. Specific pathogen-free (SPF) and conventional NC/Nga male mice were used for the experiments. Conventional mice but not SPF group spontaneously develop dermal symptom similar to that of patients with atopic dermatitis at their age of 7 weeks. They were given two types of stress, mild (20 m/min for 60 min) or strong exercise (25 m/min for 90 min), using a treadmill four times per day. The dermal symptom of the conventional group was strongly exacerbated by strong exercise but ameliorated by mild exercise. Under the standard experimental conditions, plasma concentrations of α-melanocyte-stimulating hormone (α-MSH), transforming growth factor-β (TGF-β) and substance P in conventional mice increased markedly with concomitant exacerbation of the symptom. The plasma concentrations of these proteins elevated after strong exercise but decreased after mild exercise. Under the conventional conditions, plasma levels of β-endorphin increased with time by some mechanisms enhanced by the mild exercise. These observations suggested that exercise-induced stress significantly affect the symptom of atopic dermatitis in a pivotal manner depending on the plasma levels of TGF-β, α-MSH, substance P and β-endorphin.
authors.affiliation: Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, Abeno, Osaka, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Orita
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramoto
authors.forename: Risa
authors.initials: R
authors.lastname: Inoue
authors.forename: Eisuke F
authors.initials: EF
authors.lastname: Sato
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Ishii
authors.forename: Masayasu
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003876:Dermatitis, Atopic / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005080:Exercise Test; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013047:Specific Pathogen-Free Organisms; D013312:Stress, Physiological / Q000502:physiology*; D013373:Substance P / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D000521:alpha-MSH / Q000097:blood; D001615:beta-Endorphin / Q000378:metabolism
chemical_list: D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D013373:Substance P; D007073:Immunoglobulin E; D000521:alpha-MSH; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone