title: A mathematical approach to the analysis of multiplex DNA profiles.
abstract: Multiplex DNA profiles are used extensively for biomedical and forensic purposes. However, while DNA profile data generation is automated, human analysis of those data is not, and the need for speed combined with accuracy demands a computer-automated approach to sample interpretation and quality assessment. In this paper, we describe an integrated mathematical approach to modeling the data and extracting the relevant information, while rejecting noise and sample artifacts. We conclude with examples showing the effectiveness of our algorithms.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. goorrob@mail.nih.gov
authors.forename: Robert M
authors.initials: RM
authors.lastname: Goor
authors.forename: Lisa
authors.initials: L
authors.lastname: Forman Neall
authors.forename: Douglas
authors.initials: D
authors.lastname: Hoffman
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Sherry
mesh_terms: D000465:Algorithms; D000483:Alleles; D016172:DNA Fingerprinting / Q000379:methods*; D003627:Data Interpretation, Statistical; D006801:Humans; D008957:Models, Genetic; D020080:Tandem Repeat Sequences