title: Focal activation of primary visual cortex following supra-choroidal electrical stimulation of the retina: Intrinsic signal imaging and linear model analysis.
abstract: We performed optical intrinsic signal imaging of cat primary visual cortex (Area 17 and 18) while delivering bipolar electrical stimulation to the retina by way of a supra-choroidal electrode array. Using a general linear model (GLM) analysis we identified statistically significant (p < 0.01) activation in a localized region of cortex following supra-threshold electrical stimulation at a single retinal locus.
  
  
  RESULTS
  (1) demonstrate that intrinsic signal imaging combined with linear model analysis provides a powerful tool for assessing cortical responses to prosthetic stimulation, and (2) confirm that supra-choroidal electrical stimulation can achieve localized activation of the cortex consistent with focal activation of the retina.
authors.affiliation: Division of Biomedical Science and Biochemistry and the ARC Centre of Excellence in Vision Science, Research School of Biology, Australian National University, Canberra, ACT 2601, Australia.
authors.forename: Shaun L
authors.initials: SL
authors.lastname: Cloherty
authors.forename: Markus A
authors.initials: MA
authors.lastname: Hietanen
authors.forename: Gregg J
authors.initials: GJ
authors.lastname: Suaning
authors.forename: Michael R
authors.initials: MR
authors.lastname: Ibbotson
mesh_terms: D000818:Animals; D002415:Cats; D004558:Electric Stimulation / Q000379:methods*; D005260:Female; D016014:Linear Models; D012160:Retina / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*