title: [Effect of hepatoprotector remaxol infusion on liver function in obstructive jaundice model in rats].
abstract: Remaxol is a new infusion hepatoprotector that contains succinic acid, inosine, methionine and methylglucamine. The hepatoprotective effect of remaxol on the liver function has been studied on the model of obstructive jaundice in rats, on the terms of one and two weeks after ligation of the common bile duct (M. A. Aller, et al., 2004). Sixty rats were randomly divided into six groups: sham-operated rats with cholestasis, 0.9% NaCl treated rats with cholestasis, and remaxol treated rats with cholestasis, all on the one week (per os n=10) and two weeks (n=10) terms. Remaxol was injected into the tail vein in a dose of 1 ml/100 g during the first week after the induction of cholestasis. The rats were removed from the experiment after one and two weeks of postoperative period, respectively. The size and weight of the liver and the degree of ascites were measured, and the blood samples were taken to analyze for bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, alanineaminotransferase, aspartataminotransferase. Morphological changes in the liver were also studied. The biochemical parameters of blood and morphological evolution of tissue of liver in both one and two weeks after the induction of cholestasis showed a significant hepatoprotective effect of remaxol.
authors.forename: N G
authors.initials: NG
authors.lastname: Smirnova
authors.forename: S G
authors.initials: SG
authors.lastname: Chefu
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
authors.forename: T D
authors.initials: TD
authors.lastname: Vlasov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007262:Infusions, Intravenous; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D020011:Protective Agents; C555877:Remaxol; D013386:Succinates