title: Crystal structure and cytotoxic activity of Co(II) complex containing N,N'-tetra-(4-antipyrylmethyl)-1,2-diaminoethane (TAMEN) as ligand.
abstract: The mononuclear complex, [Co(TAMEN)](ClO(4))(2) (DMSO), containing the Mannich base N,N'-tetra-(4-antipyrylmethyl)-1,2-diaminoethane (TAMEN) as ligand, was synthesized and characterised by conductometric, electronic and infrared spectroscopic properties. The single-crystal X-ray structure show the presence of two well defined units, [Co(TAMEN)](2+) and (ClO(4))(-). The complex cation contains cobalt(II) in the pseudo octahedral environment created by the N(2)O(4) donor set of TAMEN. The cobalt(II) complex have been screened for its cytotoxic activity against three cultured human cell lines established from hepatoma (Hep G2), breast (MCF-7) and lung (A549) cancers as well as on non-tumor bovine kidney (MDBK) cells. The cytotoxic activity of the ligand TAMEN was assessed on one tumor (Hep G2) and one non-tumor (MDBK) cell lines. The cobalt(II) compound was found to decrease in a time- and concentration- dependent manner the viability of tumor (A549, MCF-7, Hep G2) cell lines, while the ligand TAMEN expressed proliferative activity on hepatoma (HepG2) and bovine kidney (MDBK) cells, especially after prolonged incubation.
authors.affiliation: Institute of Chemistry Timisoara, Romanian Academy, Inorganic Chemistry Laboratory, Mihai Viteazu 24, Timisoara, Romania. emosoarca@yahoo.com
authors.forename: Elena Maria
authors.initials: EM
authors.lastname: Mosoarca
authors.forename: Ingo
authors.initials: I
authors.lastname: Pantenburg
authors.forename: Ramona
authors.initials: R
authors.lastname: Tudose
authors.forename: Gerd
authors.initials: G
authors.lastname: Meyer
authors.forename: Radostina
authors.initials: R
authors.lastname: Alexandrova
authors.forename: Reni
authors.initials: R
authors.lastname: Kalfin
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Linert
authors.forename: Otilia
authors.initials: O
authors.lastname: Costişor
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004121:Dimethyl Sulfoxide; D056945:Hep G2 Cells; D006801:Humans; D008024:Ligands; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D003035:Cobalt; D004121:Dimethyl Sulfoxide