title: [Integrated assessment of endothelio- and cardioprotective activity of macrolide antibiotics in nitric oxide deficiency model].
abstract: Experiments on laboratory animals with nitric oxide deficiency modeled by the introduction of L-NAME (NO-synthase inhibitor) revealed the endothelio- and cardioprotective effects of clarithromycin, josamycin, roxithromycin, midecamycin and azythromycin. The administration of these macrolides leads to a decrease in the resulting area of the diagram of functional indices of the state of vessels and myocardium, which is approaching the corresponding area for intact animals.
authors.forename: E S
authors.initials: ES
authors.lastname: Chernomortseva
authors.forename: M V
authors.initials: MV
authors.lastname: Pokrovskiĭ
authors.forename: L V
authors.initials: LV
authors.lastname: Titareva
authors.forename: T G
authors.initials: TG
authors.lastname: Pokrovskaia
authors.forename: V V
authors.initials: VV
authors.lastname: Gureev
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006334:Heart Function Tests; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D018942:Macrolides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000172:deficiency*; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002316:Cardiotonic Agents; D018942:Macrolides; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester