title: Review of studies on modulating enzyme activity by low intensity electromagnetic radiation.
abstract: This paper is a compilation of our findings on non-thermal effects of electromagnetic radiation (EMR) at the molecular level. The outcomes of our studies revealed that that enzymes' activity can be modulated by external electromagnetic fields (EMFs) of selected frequencies. Here, we discuss the possibility of modulating protein activity using visible and infrared light based on the concepts of protein activation outlined in the resonant recognition model (RRM), and by low intensity microwaves. The theoretical basis behind the RRM model expounds a potential interaction mechanism between electromagnetic radiation and proteins as well as protein-protein interactions. Possibility of modulating protein activity by external EMR is experimentally validated by irradiation of the L-lactate Dehydrogenase enzyme.
authors.affiliation: School of Electrical and Computer Engineering, RMIT University, GPO Box 2476 Melbourne 3001 Victoria Australia. vuk.vojisavljevic@rmit.edu.au
authors.forename: Vuk
authors.initials: V
authors.lastname: Vojisavljevic
authors.forename: Elena
authors.initials: E
authors.lastname: Pirogova
authors.forename: Irena
authors.initials: I
authors.lastname: Cosic
mesh_terms: D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D004789:Enzyme Activation / Q000528:radiation effects*; D004795:Enzyme Stability / Q000528:radiation effects; D004798:Enzymes / Q000737:chemistry* / Q000528:radiation effects*; D008027:Light; D011829:Radiation Dosage
chemical_list: D004798:Enzymes