title: Catalytic asymmetric domino Michael addition-alkylation reaction: enantioselective synthesis of dihydrofurans.
abstract: A catalytic enantioselective synthesis of dihydrofurans has been developed. 1,3-Dicarbonyl derivatives react with (E)-β,β-bromonitrostyrenes in the presence of a chiral bifunctional thiourea catalyst providing mild and efficient access to diverse polysubstituted dihydrofurans in good yields and enantioselectivities.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany. Magnus.Rueping@rwth-aachen.de
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
authors.forename: Alejandro
authors.initials: A
authors.lastname: Parra
authors.forename: Uxue
authors.initials: U
authors.lastname: Uria
authors.forename: François
authors.initials: F
authors.lastname: Besselièvre
authors.forename: Estíbaliz
authors.initials: E
authors.lastname: Merino