title: Cytotoxic sesquiterpenes from Magnolia kachirachirai.
abstract: Bioassay-guided fractionation of the root wood of Magnolia kachirachirai (Kanehira & Yamamoto) Dandy (Magnoliaceae) led to the isolation of three new compounds, kachiraterpenol (1), (E)-2,3-bis(4-hydroxy-3-methoxyphenyl)prop-2-enal (15), and kachiranol (19), together with 27 known compounds, of which 4,4'-dihydroxy-3,3'-dimethoxybenzophenone (16) was isolated for the first time from a natural source. Their structures were elucidated by spectroscopic analysis. Two of these isolates, costunolide (2) and dehydrosaussurea lactone (4), showed cytotoxic properties against MCF-7, NCI-H460, and SF-268 cancer cell lines in vitro.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Shiow-Ju
authors.initials: SJ
authors.lastname: Lee
authors.forename: Cheng-Wei
authors.initials: CW
authors.lastname: Yang
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry*; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: C556196:(E)-2,3-bis(4-hydroxy-3-methoxyphenyl)prop-2-enal; D012717:Sesquiterpenes; C556198:kachiranol; C556197:kachiraterpenol