title: The impact of psychological stress on wound healing: methods and mechanisms.
abstract: Converging and replicated evidence indicates that psychological stress can modulate wound-healing processes. This article reviews the methods and findings of experimental models of wound healing. Psychological stress can have a substantial and clinically relevant impact on wound repair. Physiologic stress responses can directly influence wound-healing processes. Furthermore, psychological stress can indirectly modulate the repair process by promoting the adoption of health-damaging behaviors. Translational work is needed to develop innovative treatments able to attenuate stress-induced delays in wound healing.
authors.affiliation: Department of Psychology, The Ohio State University, 225 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA. Gouin.1@osu.edu
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Gouin
authors.forename: Janice K
authors.initials: JK
authors.lastname: Kiecolt-Glaser
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004198:Disease Susceptibility; D006801:Humans; D007239:Infections / Q000276:immunology / Q000523:psychology; D007249:Inflammation / Q000276:immunology; D010146:Pain / Q000276:immunology / Q000523:psychology; D011598:Psychoneuroimmunology; D013315:Stress, Psychological / Q000276:immunology* / Q000523:psychology*; D014945:Wound Healing / Q000276:immunology
chemical_list: D016207:Cytokines