title: Facile domino access to chiral mono-, bi-, and tricyclic 2,3-dihydrofurans.
abstract: The asymmetric domino Michael-S(N)2 reaction of various 1,3-dicarbonyl compounds to α-bromonitroalkenes is described for the first time, employing readily available cinchona-derived bifunctional thioureas as organocatalysts. The novel transformations were highly regio-, chemo-, diastereo-, and enantioselective, which simultaneously gave the chiral tricyclic 2,3-dihydrofurans, bicyclic 2,3-dihydrofurans, and tetrasubstituted 2,3-dihydrofurans with two vicinal chiral carbon centers.
authors.affiliation: Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, 321004 Jinhua, PR China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Fan
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Li
authors.forename: Dong-Cheng
authors.initials: DC
authors.lastname: Xu
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Ge
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhu
authors.forename: Jian-Wu
authors.initials: JW
authors.lastname: Xie