title: G6PD deficiency-induced hemolysis in a Chinese diabetic patient: a case report with clinical and molecular analysis.
abstract: A 59-year-old Chinese male patient was admitted at diagnosis of type 1 diabetes with ketoacidosis. During the normalization of blood glucose with insulin, the patient developed acute hemolysis. The factors predisposing to hemolysis were not found, except the significantly diminished activity of glucose-6-phosphate dehydrogenase (G6PD). DNA analysis did not show any coding or intronic mutation in the G6PD gene. This is the first reported case of a Chinese patient in diabetic ketoacidosis with hemolysis induced by G6PD deficiency in the absence of mutations in the G6PD gene.
authors.affiliation: Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wenzhou Medical College, Zhejiang, People's Republic of China.
authors.forename: Xue-Jiang
authors.initials: XJ
authors.lastname: Gu
authors.forename: Shuo-Ping
authors.initials: SP
authors.lastname: Chen
authors.forename: Sheng-Jie
authors.initials: SJ
authors.lastname: Ge
authors.forename: Le-Qun
authors.initials: LQ
authors.lastname: Zheng
authors.forename: Da-Wang
authors.initials: DW
authors.lastname: Wang
authors.forename: Fei-Xia
authors.initials: FX
authors.lastname: Shen
mesh_terms: D002681:China; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D016883:Diabetic Ketoacidosis / Q000201:enzymology* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005954:Glucosephosphate Dehydrogenase