title: Usefulness of wireless capsule endoscopy in paediatric inflammatory bowel disease.
abstract: BACKGROUND
  Small bowel endoscopy is critical in revealing an inflammatory bowel disease (IBD) previously undetected and in classifying the IBD patients, i.e. Crohn's disease or ulcerative colitis.
  
  
  METHODS
  A prospective paediatric study on the usefulness of wireless capsule endoscopy (WCE) was performed in 117 children (age range: 4-17 years) with established or suspected IBD and compared with non endoscopic imaging tools. All patients underwent upper and lower gastrointestinal endoscopy.
  
  
  RESULTS
  In Crohn's disease patients (CD, n=44), small bowel lesions were revealed by imaging tools in 8 and by WCE in 18 patients, respectively (p<0.01). No small bowel involvement was observed in 29 ulcerative colitis patients by both imaging tools and WCE. Of 26 unclassified IBD, small bowel lesions typical of Crohn's disease were detected by imaging in 7 and by WCE in 16 (p<0.05). Of 18 patients with suspected IBD, small bowel lesions typical of Crohn's disease were observed in 9 with WCE, vs. only in 4 with imaging (p<0.01). No cases of capsule retention occurred.
  
  
  CONCLUSIONS
  WCE is valuable in revealing small bowel lesions in children with a previous diagnosis of CD and unexplained clinical and laboratory data. It is also helpful in unclassified IBD patients. This tool can influence the management and the course of IBD.
authors.affiliation: Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Nardo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Oliva
authors.forename: Federica
authors.initials: F
authors.lastname: Ferrari
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Riccioni
authors.forename: Annamaria
authors.initials: A
authors.lastname: Staiano
authors.forename: Giuliano
authors.initials: G
authors.lastname: Lombardi
authors.forename: Guido
authors.initials: G
authors.lastname: Costamagna
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cucchiara
authors.forename: Laura
authors.initials: L
authors.lastname: Stronati
mesh_terms: D000293:Adolescent; D053704:Capsule Endoscopy; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000008:administration & dosage; D003424:Crohn Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D007421:Intestine, Small / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D003287:Contrast Media