title: High-sensitivity C-reactive protein: an independent risk factor for left ventricular hypertrophy in patients with lupus nephritis.
abstract: OBJECTIVE
  To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients.
  
  
  METHODS
  287 LN patients (age: 38.54 ± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis.
  
  
  RESULTS
  The prevalence of LVH in this cohort was 21.25% (n = 61). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22-30.95) versus 3.93 (1.48-9.48) mg/L, P < .01), and correlated with left ventricular mass index (LVMI) (r = 0.314, P = .001). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor (β = 0.338, P = .002) for LVH in patients with LN.
  
  
  CONCLUSIONS
  Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.
authors.affiliation: Renal Division, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, China.
authors.forename: Beili
authors.initials: B
authors.lastname: Shi
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ni
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
authors.forename: Minfang
authors.initials: M
authors.lastname: Zhang
authors.forename: Shan
authors.initials: S
authors.lastname: Mou
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Liou
authors.initials: L
authors.lastname: Cao
authors.forename: Zanzhe
authors.initials: Z
authors.lastname: Yu
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Yan
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Qian
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D015331:Cohort Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology*; D008181:Lupus Nephritis / Q000097:blood* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein