title: Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda.
abstract: OBJECTIVE
  In Uganda, malaria is the most common disease and Ugandan people largely rely on traditional medicine. In this context, we carried out an ethnobotanical study on the Kiohima village, located close to the Kibale National Park in South-Western Uganda and investigated in vitro the antiplasmodial and cytotoxic activities of selected medicinal plants.
  
  
  METHODS
  Seventy-five plants-using adults (men and women) were interviewed to find out their plant use. From these information, 48 plants used in traditional medicine were identified and according to their reported uses and to bibliographic data, several parts of 28 plants (leaves, barks, roots), were selected and collected for biological evaluations. These samples were dried, extracted with ethyl acetate and the crude extracts were assayed for in vitro antiplasmodial and cytotoxic activities at 10 μg/mL.
  
  
  RESULTS
  One third of the screened plants showed a significant antiplasmodial activity with inhibition greater than 50% at 10 μg/mL.
  
  
  CONCLUSIONS
  These results may indicate a possible explanation of the use of some medicinal plant against malaria in the village of Kiohima and have also allowed to highlight a plant with potent antimalarial activity: Citropsis articulata root barks.
authors.affiliation: Molécules de Communication et Adaptation des Micro-Organismes, FRE 3206 CNRS/MNHN, Muséum National d'Histoire Naturelle, 57 rue Cuvier, 75005 Paris, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Lacroix
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Dennis
authors.initials: D
authors.lastname: Kamoga
authors.forename: John
authors.initials: J
authors.lastname: Kasenene
authors.forename: Jane
authors.initials: J
authors.lastname: Namukobe
authors.forename: Sabrina
authors.initials: S
authors.lastname: Krief
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mouray
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
authors.forename: Florence
authors.initials: F
authors.lastname: Brunois
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D020834:Ethnopharmacology; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D008297:Male; D016488:Medicine, African Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D014454:Uganda
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts