title: Pyridone and tetramic acid alkaloids from the spider pathogenic fungus Torrubiella sp. BCC 2165.
abstract: Torrubiellones A-D (1-4), new pyridone and tetramic acid alkaloids, were isolated from the spider pathogenic fungus Torrubiella sp. BCC 2165. Torrubiellone A (1) exhibited antimalarial activity with an IC(50) value of 8.1 μM, while it showed very weak cytotoxic activity.
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, Thailand. isaka@biotec.or.th
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Panida
authors.initials: P
authors.lastname: Chinthanom
authors.forename: Sumalee
authors.initials: S
authors.lastname: Supothina
authors.forename: Punsa
authors.initials: P
authors.lastname: Tobwor
authors.forename: Nigel L
authors.initials: NL
authors.lastname: Hywel-Jones
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006999:Hypocreales / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013112:Spiders / Q000382:microbiology*
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000970:Antineoplastic Agents; D011728:Pyridones; D011760:Pyrrolidinones; C555085:torrubiellone A; C009435:tetramic acid