title: Antifungal abietane-type diterpenes from the cones of Taxodium distichum Rich.
abstract: The chemical composition of Taxodium distichum cones and the antifungal activities of twelve diterpenoids against two wood decay fungi, Trametes versicolor (white-rot) and Fomitopsis palustris (brown-rot) were examined. The chemical composition of the major extractive fraction, the n-C(6)H(14) extract, was evaluated and its antifungal properties were identified. Twelve diterpenoids including ten abietane-type components were isolated from the n-C(6)H(14) extract: 6,7-dehydroferruginol (1), ferruginol (2), 6,7-dehydroroyleanone (3), sandaracopimaric acid (4), taxodione (5), taxodal (6), taxodone (7), sugiol (8), xanthoperol (9), salvinolone (10), 5,6-dehydrosugiol (11), and 14-deoxycoleon U (12). Compounds 5 and 12 were highly active against both wood-decay fungi. In particular, the activities of these compounds against F. palustris were potent. The results suggest that the position and the number of hydroxyl groups on abietane-type structures may be related to antifungal activities against T. versicolor and F. palustris.
authors.affiliation: The United Graduate School of Agricultural Science, Iwate University, 18-8 Ueda 3-chome, Morioka, Iwate, Japan. nori1005@tds1.tr.yamagata-u.ac.jp
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kusumoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ashitani
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Murayama
authors.forename: Koichi
authors.initials: K
authors.lastname: Ogiyama
authors.forename: Koetsu
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D045784:Abietanes / Q000032:analysis* / Q000494:pharmacology; D055453:Coriolaceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry; D005659:Fungicides, Industrial / Q000032:analysis / Q000494:pharmacology; D032489:Taxodium / Q000737:chemistry*; D055454:Trametes / Q000187:drug effects
chemical_list: D045784:Abietanes; D004224:Diterpenes; D005659:Fungicides, Industrial