title: Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.
authors.affiliation: Institut für Organische Chemie und Biomolekulares, Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Harmrolfs
authors.forename: Marco
authors.initials: M
authors.lastname: Brünjes
authors.forename: Gerald
authors.initials: G
authors.lastname: Dräger
authors.forename: Heinz G
authors.initials: HG
authors.lastname: Floss
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Florian
authors.initials: F
authors.lastname: Taft
authors.forename: Andreas
authors.initials: A
authors.lastname: Kirschning
mesh_terms: D000192:Actinomycetales / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D019732:Amide Synthases / Q000235:genetics / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003500:Cyclization; D003543:Cysteamine / Q000031:analogs & derivatives; D006801:Humans; D008453:Maytansine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009154:Mutation
chemical_list: D000970:Antineoplastic Agents; C507695:seco-proansamitocin; D008453:Maytansine; D003543:Cysteamine; C015682:ansamitocins; D019732:Amide Synthases