title: Comparison of selenohomolanthionine and selenomethionine in terms of selenium distribution and toxicity in rats by bolus administration.
abstract: The distribution and metabolism of selenohomolanthionine (4,4'-selenobis[2-aminobutanoic acid], SeHLan), a newly identified selenoamino acid in selenized Japanese pungent radish, were compared with those of selenomethionine (SeMet) in rats. Either selenoamino acid was injected intravenously at a bolus dose of 1.0 mg Se/kg body weight. SeMet was preferably accumulated in the pancreas, increasing the serum amylase level, an index of pancreatic damage. SeHLan was preferably accumulated in the kidneys, raising the serum creatinine level, an index of kidney damage. On the other hand, the levels of two major urinary selenometabolites, i.e., Se-methylseleno-N-acetyl-galactosamine and trimethylselenonium, were comparable between SeHLan- and SeMet-administered rats, suggesting that there may be no differences in the efficiency of metabolism of these two selenoamino acids to the urinary selenometabolites despite the difference in distribution. SeHLan is expected to be a potential supplemental source of Se without inducing the onset of pancreatic damage. The specific toxicity of SeHLan to the kidneys may be avoided if its dose is lower than the one used in the present study.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mikami
authors.forename: Yasumi
authors.initials: Y
authors.lastname: Anan
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Ogra
mesh_terms: D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D006711:Homocystine / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D012645:Selenomethionine / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*
chemical_list: D006711:Homocystine; D012645:Selenomethionine; D012643:Selenium