title: Cadmium and mercury-induced hyperglycemia in the fresh water crab, Oziotelphusa senex senex: involvement of neuroendocrine system.
abstract: The effect of exposure to sublethal concentrations of cadmium chloride and mercuric chloride on hemolymph glucose levels of the freshwater crab, Oziotelphusa senex senex, was studied. Intact crabs exposed to cadmium or mercury exhibited a significant hyperglycemia compared to controls, but no significant differences in hemolymph glucose level were detected among the eyestalkless crabs after exposure to metals, suggesting that the effect of metals could be on the sinus gland in the eyestalks, increasing secretion of the hyperglycemic hormone. To test this hypothesis, eyestalks were collected from control and metal exposed crabs, and tested for hyperglycemic effect and also for the hyperglycemic hormone levels. The levels of hyperglycemic hormone and the hyperglycemic effect were significantly low in the eyestalks collected from metal exposed crabs when compared with eyestalks from control crabs. These results strongly suggest that metals act, at least in part, by triggering the secretion of hyperglycemic hormone from the eyestalk.
authors.affiliation: Department of Biotechnology, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India. reddy_1955@yahoo.co.in
authors.forename: P Sreenivasula
authors.initials: PS
authors.lastname: Reddy
authors.forename: P Ramachandra
authors.initials: PR
authors.lastname: Reddy
authors.forename: S B
authors.initials: SB
authors.lastname: Sainath
mesh_terms: D000818:Animals; D003386:Brachyura / Q000187:drug effects* / Q000378:metabolism; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005618:Fresh Water / Q000737:chemistry; D005947:Glucose / Q000378:metabolism; D006458:Hemolymph / Q000378:metabolism; D006943:Hyperglycemia / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D008628:Mercury / Q000378:metabolism / Q000633:toxicity*; D009490:Neurosecretory Systems / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical; D002104:Cadmium; D008628:Mercury; D005947:Glucose