title: Comparison of IgG avidity assays in the confirmation of the diagnosis of cytomegalovirus primary infection.
abstract: We have compared three ELISA techniques and one chemiluminescence immunoassay technique for determining cytomegalovirus (CMV) immunoglobulin G (IgG) avidity in serum samples from patients with recent and past CMV infections. Sensitivity varied from 84.6% to 100%; and specificity from 78.6% to 100%. IgG avidity assays appear to be adequate additional tools for characterizing CMV infections.
authors.affiliation: Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: María Eulalia
authors.initials: ME
authors.lastname: Guisasola
authors.forename: Belén
authors.initials: B
authors.lastname: Ramos
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Sanz
authors.forename: Isabel
authors.initials: I
authors.lastname: García-Bermejo
authors.forename: Fernando
authors.initials: F
authors.lastname: De Ory Manchón
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D000915:Antibody Affinity; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008163:Luminescent Measurements / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M