title: CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke.
abstract: Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
authors.affiliation: Neuroimmunology Research, R&D-31, Portland Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA.
authors.forename: Xuefang
authors.initials: X
authors.lastname: Ren
authors.forename: Kozaburo
authors.initials: K
authors.lastname: Akiyoshi
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Vandenbark
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Hurn
authors.forename: Halina
authors.initials: H
authors.lastname: Offner
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D015704:CD4 Antigens / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D051858:Forkhead Transcription Factors; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D020521:Stroke / Q000276:immunology* / Q000503:physiopathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism
chemical_list: D015704:CD4 Antigens; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D053645:Interleukin-2 Receptor alpha Subunit