title: [Correlation of microalbuminuria and fibrinogen to the severity of coronary artery lesions in patients with metabolic syndrome].
abstract: OBJECTIVE
  To investigate the correlation of microalbuminuria (MA) and fibrinogen (Fib) to the severity of coronary artery lesions in patients with metabolic syndrome (MS).
  
  
  METHODS
  Eighty-five patients with MS undergoing coronary artery angiography were divided, according to the number of vessels involved, into multivessel disease group and non-multivessel disease group, and also according to the modified Gensini score, into severe lesion (Gensini score>20) and non-severe lesion group. The correlations of MA and Fib to the number of involved vessels and the severity of the lesions were analyzed.
  
  
  RESULTS
  The urinary albumin to creatinine ratio (ACR) and Fib were significantly different between the multivessel and non-multivessel disease groups (P<0.05), and were found to be positively correlated to the number of coronary artery lesion (r=0.378, P=0.000; r=0.327, P=0.002). ACR, Fib, sex, smoking history and HDL-C differed significantly between severe lesion and non-severe lesion groups (P<0.05), and ACR and Fib showed positive correlations to the Gensini score (r=0.337, P=0.002; r=0.286, P=0.008). Logistic regression analysis identified ACR as an independent predictor of multivessel disease (B=2.655, P=0.000) and Gensini score (B=1.803, P=0.009), independent of sex, age, body mass index, smoking history, diabetes mellitus, LDL-C and HDL-C.
  
  
  CONCLUSIONS
  MA and Fib are positively correlated to the severity of coronary artery lesion, and MA is an independent predictor of multivessel disease and Gensini score in patients with MS.
authors.affiliation: Panyu Central Hospital, Guangzhou 511400, China. luobjack@163.com
authors.forename: Bang-jun
authors.initials: BJ
authors.lastname: Luo
authors.forename: Dan-qing
authors.initials: DQ
authors.lastname: Yu
authors.forename: Ji-yan
authors.initials: JY
authors.lastname: Chen
authors.forename: Ying-ling
authors.initials: YL
authors.lastname: Zhou
authors.forename: Ning
authors.initials: N
authors.lastname: Tan
mesh_terms: D000368:Aged; D000419:Albuminuria; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000652:urine*; D008875:Middle Aged
chemical_list: D005340:Fibrinogen