title: Aerosolized tacrolimus: a case report in a lung transplant recipient.
abstract: Long-term outcomes after lung transplantation remain poor mainly to the development of bronchiolitis obliterans syndrome (BOS). Currently, treatment options for BOS are very limited. Strategies to prevent and treat this complication include the use of aerosolized therapy with only cyclosporine used in patients to date. We describe the use of aerosolized tacrolimus in a lung transplant recipient with BOS. The patient demonstrated clinical improvement in functional capacity and oxygenation while receiving tacrolimus by nebulization. Further research is needed to study whether aerosolized tacrolimus is beneficial in lung transplant recipients with BOS.
authors.affiliation: Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA. don.hayes@uky.edu
authors.forename: D
authors.initials: D
authors.lastname: Hayes
authors.forename: J B
authors.initials: JB
authors.lastname: Zwischenberger
authors.forename: H M
authors.initials: HM
authors.lastname: Mansour
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols; D001989:Bronchiolitis Obliterans / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004417:Dyspnea / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016040:Lung Transplantation / Q000009:adverse effects*; D009330:Nebulizers and Vaporizers; D012129:Respiratory Function Tests; D016559:Tacrolimus / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D007166:Immunosuppressive Agents; D016559:Tacrolimus