title: Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from Ileal Crohn's disease biopsy tissue.
abstract: Escherichia coli UM146 was isolated from the ileum of a Crohn's disease patient. It adheres to and invades enterocytes and can replicate inside macrophages. Its complete genome sequence reveals that it is most closely related to the human urinary tract pathogen E. coli CFT073, but it has a host of genes that are novel and to which no function has been ascribed.
authors.affiliation: Department of Animal Science, University of Manitoba, Winnipeg, Canada. denis_krause@umanitoba.ca
authors.forename: Denis O
authors.initials: DO
authors.lastname: Krause
authors.forename: Ainsley C
authors.initials: AC
authors.lastname: Little
authors.forename: Scot E
authors.initials: SE
authors.lastname: Dowd
authors.forename: Charles N
authors.initials: CN
authors.lastname: Bernstein
mesh_terms: D001422:Bacterial Adhesion; D001706:Biopsy; D003424:Crohn Disease / Q000382:microbiology*; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D020895:Enterocytes / Q000382:microbiology; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification*; D016680:Genome, Bacterial; D006801:Humans; D007082:Ileum / Q000382:microbiology*; D008264:Macrophages / Q000382:microbiology; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial