title: Molecular diagnosis of gestational trophoblastic disease.
abstract: Gestational trophoblastic disease consists of well-defined diagnostic entities of proliferative disorder of the placenta, of which hydatidiform moles are common lesions. Even with available ancillary studies, including ploidy and immunohistochemistry analyses, histological diagnosis of molar pregnancies can be challenging in a significant percentage of the cases. Reliable diagnostic approaches with improved sensitivity and specificity are highly desirable. Recently, PCR-based short tandem repeat DNA genotyping has emerged as a powerful diagnostic measure in the workup of gestational trophoblastic disorders, particularly hydatidiform moles.
authors.affiliation: Department of Pathology, Yale University School of Medicine, BML 254B, 310 Cedar Street, New Haven, CT 06520-8023, USA. pei.hui@yale.edu
authors.forename: Pei
authors.initials: P
authors.lastname: Hui
mesh_terms: D005260:Female; D005838:Genotype; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D018895:Microsatellite Repeats; D025202:Molecular Diagnostic Techniques; D010920:Placenta / Q000473:pathology*; D011003:Ploidies; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D012680:Sensitivity and Specificity; D014328:Trophoblastic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology