title: Helical TomoTherapy versus sterotactic Gamma Knife radiosurgery in the treatment of single and multiple brain tumors: a dosimetric comparison.
abstract: The objective was to compare the dosimetry of Helical TomoTherapy (TOMO) and Gamma Knife (GK) treatment plans for tumor and normal brain in the treatment of single and multiple brain tumors. An anthropomorphic Rando Head phantom was used to compare the dosimetry of TOMO and GK. Eight brain tumors of various shapes, sizes and locations were used to generate 10 plans. The radiation dose was 20 Gy prescribed to the 100% isodose line for TOMO plans and to the 50% for the GK plans. Dose Volume Histograms for tumor and brain were compared. Equivalent Uniform Dose (gEUD), Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) were performed and used for plan comparisons. Average minimum, mean, median and maximum tumor doses were 19.93, 27.83, 27.38, 39.60 Gy for GK and 20.17, 20.60, 20.59, 20.90 Gy for TOMO. Average gEUD values for tumor and normal brain were 25.0 and 7.2 Gy for GK and 20.7 and 8.1 Gy for TOMO. Conformity indices (CI) were similar for both modalities. Gradient indices (GI) were greater for TOMO. A combination plan was also generated using all eight tumors. TOMO was able to target all eight tumors simultaneously resulting in mean tumor and brain doses of 20.5 and 9.35 Gy, respectively. Due to the maximum limit of 50 beams per plan, GK was unable to provide a treatment plan for all eight tumors. GK provides an advantage for all tumor sizes with respect to tumor and normal brain dose. Clinical studies are needed to correlate these dosimetric findings with patient outcomes.
authors.affiliation: Wayne State University School of Medicine, Detroit, MI, USA. rakowski@karmanos.org
authors.forename: Tushar
authors.initials: T
authors.lastname: Kumar
authors.forename: Joseph
authors.initials: J
authors.lastname: Rakowski
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.forename: Mazin
authors.initials: M
authors.lastname: Alkhafaji
authors.forename: Jacob
authors.initials: J
authors.lastname: Burmeister
authors.forename: Tammy
authors.initials: T
authors.lastname: Austin
authors.forename: Maria
authors.initials: M
authors.lastname: Vlachaki
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D036542:Tomography, Spiral Computed