title: Replicon particle vaccine protects swine against influenza.
abstract: An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene.
authors.affiliation: Department of Animal Science, College of Agriculture, Iowa State University, Ames, IA 50010, United States. bboswort@iastate.edu
authors.forename: B
authors.initials: B
authors.lastname: Bosworth
authors.forename: M M
authors.initials: MM
authors.lastname: Erdman
authors.forename: D L
authors.initials: DL
authors.lastname: Stine
authors.forename: I
authors.initials: I
authors.lastname: Harris
authors.forename: C
authors.initials: C
authors.lastname: Irwin
authors.forename: M
authors.initials: M
authors.lastname: Jens
authors.forename: A
authors.initials: A
authors.lastname: Loynachan
authors.forename: K
authors.initials: K
authors.lastname: Kamrud
authors.forename: D L
authors.initials: DL
authors.lastname: Harris
mesh_terms: D000524:Alphavirus / Q000235:genetics / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D019590:Nucleocapsid Proteins; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000662:veterinary*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000276:immunology*; D012093:Replicon / Q000276:immunology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D058425:Vaccines, Virus-Like Particle / Q000276:immunology; D014758:Viral Core Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; D016601:RNA-Binding Proteins; D058425:Vaccines, Virus-Like Particle; D014758:Viral Core Proteins