title: IDH1 mutant structures reveal a mechanism of dominant inhibition.
authors.affiliation: School of Life Sciences, Institutes for Biological Sciences, Fudan University, Shanghai 20032, China.
authors.forename: Shimin
authors.initials: S
authors.lastname: Zhao
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan
mesh_terms: D019943:Amino Acid Substitution; D019281:Dimerization; D007521:Isocitrate Dehydrogenase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D007523:Isocitrates / Q000737:chemistry; D009154:Mutation; D011485:Protein Binding; D017434:Protein Structure, Tertiary
chemical_list: D007523:Isocitrates; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human