title: [Analysis of the factors related to glomerular filtration rate in type 2 diabetes without albuminuria].
abstract: OBJECTIVE
  To analyze the risk factors affecting the glomerular filtration rate (GFR) in type 2 diabetic patients without albuminuria.
  
  
  METHODS
  A total of 131 type 2 diabetic patients with normal urinary albumin excretion rate (UAER) were divided into normal GFR group and decreased GFR group. The factors relevant to GFR were analyzed by multiple factors regression.
  
  
  RESULTS
  Age, course of diabetes, systolic blood pressure, prevalence of hypertension, the level of serum creatinine (SCr), blood urea nitrogen (BUN) and uric acid (UA) were significantly higher in decreased GFR group than in normal GFR group. Multivariate regression showed that SCr, age, systolic blood pressure, and UA were negatively correlated to GFR.
  
  
  CONCLUSIONS
  Reduced GFR occurs in some type 2 diabetic patients without albuminuria. SCr, age, systolic blood pressure and UA are the major factors related to decreased GFR. The degree of early renal damage in diabetic patients can be better evaluated by combining GFR and UAER.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Ji'nan University, Guangzhou 510630, China. yhlu@163.com
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Lu
authors.forename: Lie
authors.initials: L
authors.lastname: Feng
authors.forename: Ya-bin
authors.initials: YB
authors.lastname: Jiang
authors.forename: You-fen
authors.initials: YF
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000150:complications / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors