title: Cooperative melting in caged dimers with only two DNA duplexes.
abstract: Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Eryazici
authors.forename: Tatiana R
authors.initials: TR
authors.lastname: Prytkova
authors.forename: George C
authors.initials: GC
authors.lastname: Schatz
authors.forename: SonBinh T
authors.initials: ST
authors.lastname: Nguyen
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D019281:Dimerization; D056004:Molecular Dynamics Simulation; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D044367:Phase Transition; D044366:Transition Temperature
chemical_list: D004247:DNA