title: Preliminary findings on the efficacy of selamectin in the treatment of dogs naturally infected with Dirofilaria repens.
abstract: Subcutaneous dirofilariosis caused by Dirofilaria repens is common in dogs and it is an emerging helminthozoonosis in Europe, Asia, Africa and also in Hungary. Macrocyclic lactones are used for preventing the infection; however, their activity against the microfilariae and mature stages of this species is questionable. Selamectin is widely used for the prophylaxis of heartworm (D. immitis) infection. The objective of the present study was to test the microfilaricidal efficacy of the topical formulation of selamectin in dogs naturally infected with D. repens . A total of 78 Beagle dogs were examined for the presence of circulating microfilariae by Knott's test. Twenty-three of the microfilaraemic dogs were divided into four groups and included in the trial. The dogs received monthly or biweekly selamectin treatment and were subjected to monthly blood testing for a period of 252 or 336 days. At the end of the study, 65% of the dogs were not microfilaraemic and the rest had low number of microfilariae in their blood. These results indicate that chronic spot-on selamectin treatment may be a useful tool also in the control of canine subcutaneous dirofilariosis.
authors.affiliation: Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent István University, István u. 2 H-1078 Budapest, Hungary. jacso.olga@aotk.szie.hu
authors.forename: Olga
authors.initials: O
authors.lastname: Jacsó
authors.forename: Eva
authors.initials: E
authors.lastname: Fok
authors.forename: Gabriella
authors.initials: G
authors.lastname: Kiss
authors.forename: Gábor
authors.initials: G
authors.lastname: Kökény
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lang
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D004182:Dirofilaria / Q000145:classification*; D004184:Dirofilariasis / Q000188:drug therapy*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C414354:selamectin