title: Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform.
abstract: A novel active valving technique, whereby paraffin wax plugs in microchannels on a centrifugal microfluidic platform are actuated using focused infrared (IR) radiation is demonstrated in this report. Microchannels were simultaneously or sequentially opened using a stationary IR source by forming wax plugs with similar or differing melting points. The presented wax plugs offer key advantages over current active valving techniques, including a less involved fabrication procedure, a simpler actuation process, and the ability to multiplex experiment with active valves. In addition, a new technique for automated liquid reagent storage and release on the microfluidic disc platform, based on the formation and removal of a wax layer, is demonstrated. Overall, the techniques presented in this report offer novel methods for liquid handling, separation, and storage on the centrifugal microfluidic disc platform.
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA. kabisamr@uci.edu
authors.forename: Kameel
authors.initials: K
authors.lastname: Abi-Samra
authors.forename: Ryan
authors.initials: R
authors.lastname: Hanson
authors.forename: Marc
authors.initials: M
authors.lastname: Madou
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gorkin
mesh_terms: D002498:Centrifugation; D016250:Compact Disks; D004867:Equipment Design; D007259:Infrared Rays; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D008956:Models, Chemical; D010232:Paraffin / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D010232:Paraffin