title: A closed-loop brain computer interface for real-time seizure detection and control.
abstract: The worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by available therapies. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. In this paper, a portable closed-loop brain computer interface for seizure control was developed and shown with several aspects of advantages, including high seizure detection rate (92-99% during wake-sleep states), low false detection rate (1.2-2.5%), and small size. The seizure detection and electrical stimulation latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. Experimental data from freely moving rats supported the functional possibility of a real-time closed-loop seizure controller.
authors.affiliation: Department of Computer Science and Information Engineering & the Institute of Medical Informatics, National Cheng Kung University, Tainan 701, Taiwan. sfliang@mail.ncku.edu.tw
authors.forename: Sheng-Fu
authors.initials: SF
authors.lastname: Liang
authors.forename: Fu-Zen
authors.initials: FZ
authors.lastname: Shaw
authors.forename: Chung-Ping
authors.initials: CP
authors.lastname: Young
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Chang
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Liao
mesh_terms: D000818:Animals; D001676:Biofeedback, Psychology / Q000295:instrumentation*; D003199:Computer Systems; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D051381:Rats; D012640:Seizures / Q000175:diagnosis* / Q000517:prevention & control*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013813:Therapy, Computer-Assisted / Q000379:methods*; D014584:User-Computer Interface