title: Molecular mechanisms of bone 18F-NaF deposition.
abstract: There is renewed interest in (18)F-NaF bone imaging with PET or PET/CT. The current brief discussion focuses on the molecular mechanisms of (18)F-NaF deposition in bone and presents model-based approaches to quantifying bone perfusion and metabolism in the context of preclinical and clinical applications of bone imaging with PET.
authors.affiliation: Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1782, USA. jczernin@mednet.ucla.edu
authors.forename: Johannes
authors.initials: J
authors.lastname: Czernin
authors.forename: Nagichettiar
authors.initials: N
authors.lastname: Satyamurthy
authors.forename: Christiaan
authors.initials: C
authors.lastname: Schiepers
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000000981:diagnostic imaging; D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism*; D017357:Cyclotrons; D004339:Drug Compounding; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D051379:Mice; D008954:Models, Biological; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D051381:Rats; D012969:Sodium Fluoride / Q000138:chemical synthesis / Q000493:pharmacokinetics*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride