title: Maternal depressive history, teen 5HTTLPR genotype, and the processing of emotional faces: Exploring mechanisms of risk.
abstract: Variations in the serotonin transporter gene (5HTTLPR) and biased processing of face-emotion displays both have been implicated in the transmission of depression risk, but little is known about developmental influences on these relationships. Within a community sample of adolescents, we examine whether 5HTTLPR genotype moderates the link between maternal depressive history and errors in face-emotion labeling. When controlling for current levels of depression and anxiety among youth, a two-way interaction between maternal depressive history and 5HTTLPR genotype was detected. Specifically, adolescents whose mothers reported a depressive history and who had a low expressing genotype made more errors in classifying emotional faces when compared with adolescents with an intermediate or high expressing genotype, with or without maternal depression history. These findings highlight the complex manner in which maternal depression and genetic risk may interact to predict individual differences in social information processing.
authors.affiliation: Columbia University, New York State Psychiatry Institute, New York, 10032, United States. jacobsr@childpsych.columbia.edu
authors.forename: Rachel H
authors.initials: RH
authors.lastname: Jacobs
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
authors.forename: Michael E
authors.initials: ME
authors.lastname: Schoeny
authors.forename: David B
authors.initials: DB
authors.lastname: Henry
authors.forename: Jackie K
authors.initials: JK
authors.lastname: Gollan
authors.forename: Gregory
authors.initials: G
authors.lastname: Moy
authors.forename: Edwin H
authors.initials: EH
authors.lastname: Cook
authors.forename: Lauren S
authors.initials: LS
authors.lastname: Wakschlag
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000502:physiology* / Q000523:psychology; D001007:Anxiety / Q000235:genetics / Q000523:psychology; D003863:Depression / Q000235:genetics / Q000523:psychology; D005149:Facial Expression; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008606:Mental Processes / Q000502:physiology*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins