title: Alpha-1-syntrophin protein is differentially expressed in human cancers.
abstract: We studied the expression of α1-syntrophin (SNTA1) protein in histologically confirmed esophageal, stomach, lung, colon, rectal and breast cancerous tissue samples. Our results suggest a significant decrease in the expression level of SNTA1 protein in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) compared with their respective controls while a significant increase in expression of SNTA1 protein compared with the normal tissue was observed in breast carcinoma samples. No significant difference in expression of SNTA1 protein was observed in stomach, lung, colon and rectal cancers. Our results suggest that SNTA1 has a role in carcinogenesis and could possibly be used as a novel diagnostic or prognostic marker in esophageal and breast cancers.
authors.affiliation: Department of Biotechnology, University of Kashmir, Jammu and Kashmir, India.
authors.forename: Hina F
authors.initials: HF
authors.lastname: Bhat
authors.forename: Rafia A
authors.initials: RA
authors.lastname: Baba
authors.forename: Muneesa
authors.initials: M
authors.lastname: Bashir
authors.forename: Safder
authors.initials: S
authors.lastname: Saeed
authors.forename: Deeba
authors.initials: D
authors.lastname: Kirmani
authors.forename: Mudassir M
authors.initials: MM
authors.lastname: Wani
authors.forename: Nisar A
authors.initials: NA
authors.lastname: Wani
authors.forename: Khursheed A
authors.initials: KA
authors.lastname: Wani
authors.forename: Firdous A
authors.initials: FA
authors.lastname: Khanday
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009124:Muscle Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; D009124:Muscle Proteins; C091825:syntrophin alpha1