title: Factors associated with long-term mortality in acute pancreatitis.
abstract: OBJECTIVE
  Knowledge of the long-term prognosis of acute pancreatitis (AP) is limited. The aims were to investigate: (1) prognostic factors associated with long-term mortality in patients with AP; (2) whether or not the level of serum (S-)amylase at admission had an impact on the prognosis; (3) causes of death in these patients.
  
  
  METHODS
  During 1977-1982, patients who were admitted to the five main hospitals in Copenhagen with a diagnosis of AP or chronic pancreatitis (CP) were included in a prospective cohort, the Copenhagen Pancreatitis Study (CPS); in 2008, they were followed up by linkage to the Danish Registries. The analyzed subcohort consisted of 352 patients with probable AP (n = 54) or definite AP (n = 298).
  
  
  RESULTS
  Multivariate Cox regression analysis showed that significant factors associated with mortality were age, alcohol, and diabetes, whereas female gender, co-living and employment were associated with better survival. The S-amylase level had no impact on mortality. The most frequent causes of death were cardiovascular diseases, digestive diseases, and malignancies.
  
  
  CONCLUSIONS
  Age, alcohol and diabetes had a significant impact on survival whereas the S-amylase level did not.
authors.affiliation: Department of Gastroenterology, Hvidovre Hospital, Copenhagen, Denmark. mille@dadlnet.dk
authors.forename: Camilla
authors.initials: C
authors.lastname: Nøjgaard
authors.forename: Peter
authors.initials: P
authors.lastname: Matzen
authors.forename: Flemming
authors.initials: F
authors.lastname: Bendtsen
authors.forename: Jens Rikardt
authors.initials: JR
authors.lastname: Andersen
authors.forename: Erik
authors.initials: E
authors.lastname: Christensen
authors.forename: Ulrik
authors.initials: U
authors.lastname: Becker
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D000681:Amylases / Q000097:blood*; D002318:Cardiovascular Diseases / Q000401:mortality; D002423:Cause of Death; D003718:Denmark / Q000453:epidemiology; D048909:Diabetes Complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality; D010195:Pancreatitis / Q000175:diagnosis* / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000681:Amylases