title: A common origin of synaptic vesicles undergoing evoked and spontaneous fusion.
abstract: There is a longstanding controversy on the identity of synaptic vesicles undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested that spontaneous release is driven by a resting pool of synaptic vesicles refractory to stimulation. We found that cross-depletion of spontaneously or actively recycling synaptic vesicle pools occurred on stimulation in rat hippocampal neurons and identified the recycling pool as a major source of spontaneous release.
authors.affiliation: Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Hua
authors.forename: Raunak
authors.initials: R
authors.lastname: Sinha
authors.forename: Magalie
authors.initials: M
authors.lastname: Martineau
authors.forename: Martin
authors.initials: M
authors.lastname: Kahms
authors.forename: Jürgen
authors.initials: J
authors.lastname: Klingauf
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism; D008561:Membrane Fusion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism*