title: MicroRNA-196: critical roles and clinical applications in development and cancer.
abstract: The discovery of microRNAs (miRNAs) represents one of the most significant advances in biological and medical sciences in the last decade. Hundreds of miRNAs have been identified in plants, viruses, animals and human beings, and these tiny, non-coding RNA transcripts have been found to play crucial roles in important biological processes involved in human health and disease. Recently, many studies have demonstrated that miR-196 plays critical roles in normal development and in the pathogenesis of human disease processes such as cancer. Several investigations have implemented cell culture and animal models to explore the potential molecular mechanisms of miR-196. This review provides updated information about the structure of the miR-196 gene and the roles of miR-196 in development, cancer and disease formation. Importantly, we discuss the possible molecular mechanisms whereby miR-196 regulates cellular functions including targeting molecules and gene regulation pathways; potential clinical applications are addressed, as well as future directions for investigation. miR-196a may prove to be a novel therapeutic target for several cancers.
authors.affiliation: Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. jchen@bcm.tmc.edu
authors.forename: Changyi
authors.initials: C
authors.lastname: Chen
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lidong
authors.initials: L
authors.lastname: Zhang
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Weakley
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Yao
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs