title: Grand challenge commentary: Exploiting single-cell variation for new antibiotics.
abstract: Variations between single members of a bacterial population can lead to antibiotic resistance that is not gene based. The future of effective infectious disease management might depend on a better understanding of this phenomenon and the potential to manipulate both it and microbial population dynamics in general.
authors.affiliation: Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa. estrauss@sun.ac.za
authors.forename: Erick
authors.initials: E
authors.lastname: Strauss
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics*; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control; D024881:Drug Resistance, Bacterial; D017053:Infection Control; D010641:Phenotype
chemical_list: D000900:Anti-Bacterial Agents