title: Synthesis and electrografting of dendron anchored OEGylated surfaces and their protein adsorption resistance.
abstract: In this study, a series of electrochemically active oligo(ethylene glycol) (OEG) linear-dendrons have been synthesized and grafted onto electrode surfaces by cyclic voltammetry (CV) to improve protein resistance. Dendronized molecules with peripheral carbazole functionality and branching architecture enabled tethering of the poly(ethylene glycol) (PEG) or OEG group with a predictable number of electrochemical reactive groups affecting OEG distribution and orientation. It is possible that ample spacing between the OEG chains affects the intrinsic hydration of these layers and thus surface protein resistance. The films were characterized by CV, surface plasmon resonance (SPR), static contact angle measurements, and atomic force microscopy (AFM). This approach should enable improved nonbiofouling properties on biorelevant electrode surfaces (metal or metal oxides) by potentiostatic or potentiodynamic electrochemical methods, providing an alternative to the self-assembled monolayer (SAM) approach for anchoring PEG layers.
authors.forename: Mary Jane L
authors.initials: MJ
authors.lastname: Felipe
authors.forename: Ramakrishna R
authors.initials: RR
authors.lastname: Ponnapati
authors.forename: Roderick B
authors.initials: RB
authors.lastname: Pernites
authors.forename: Pampa
authors.initials: P
authors.lastname: Dutta
authors.forename: Rigoberto C
authors.initials: RC
authors.lastname: Advincula
mesh_terms: D001665:Binding Sites; D050091:Dendrimers / Q000138:chemical synthesis*; D004595:Electroplating / Q000379:methods*; D008422:Materials Testing; D008968:Molecular Conformation; D011092:Polyethylene Glycols / Q000138:chemical synthesis*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D011506:Proteins; D011092:Polyethylene Glycols