title: Frequent expression of gp46 in adult T-cell leukemia/lymphoma: an immunohistochemical study of 40 cases.
abstract: Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disease caused by human T-cell lymphotropic virus type 1 (HTLV-1) infection. HTLV-1 is spread by cell-to-cell transmission via the gp46-197 region, from Asp197 to Leu216, in the envelope protein gp46. A correlation exists between the prevalence and titer of the antibody recognizing the gp46-197 region (anti-gp46-197 antibody) and the severity of ATLL. In the present study, immunohistochemical staining was performed on samples of paraffin embedded lymph nodes of three different histological types of ATLL (anaplastic large cell type, n = 10; pleomorphic type, n = 10; and Hodgkin's-like type, n = 10) from 30 cases and 10 cases of HTLV-associated lymphadenitis. Of the three ATLL subtypes, gp46 expression was highest in the anaplastic large cell type, followed by the pleomorphic type and Hodgkin's-like type (mean: 53.4%, 34.9% and 16.0%, respectively; P= 0.0003). In HTLV-1 associated lymphadenitis cases, gp46 positive cells were rarely seen (4.0%). These results suggest that gp46-197 immunohistochemical staining can be a useful histological indicator for prediction of the aggressiveness of ATLL and prognosis for ATLL patients.
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan. jkiyasu@med.kyushu-u.ac.jp
authors.forename: Junichi
authors.initials: J
authors.lastname: Kiyasu
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Sagara
authors.forename: Kei
authors.initials: K
authors.lastname: Kohno
authors.forename: Kensaku
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshizo
authors.initials: Y
authors.lastname: Kimura
authors.forename: Keiko
authors.initials: K
authors.lastname: Hashikawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Niino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sugita
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D015686:Gene Products, env / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D015682:Retroviridae Proteins, Oncogenic / Q000096:biosynthesis*
chemical_list: D015686:Gene Products, env; D015682:Retroviridae Proteins, Oncogenic; C055266:gp46 protein, Human T-cell leukemia virus type I