title: Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum.
abstract: In the central nervous system, electrical signals passing along nerve cells are speeded by cells called oligodendrocytes, which wrap the nerve cells with a fatty layer called myelin. This layer is important for rapid information processing, and is often lost in disease, causing mental or physical impairment in multiple sclerosis, stroke, cerebral palsy and spinal cord injury. The myelin speeds the information flow in two ways, by decreasing the capacitance of the nerve cell and by increasing its membrane resistance, but little is known about the latter aspect of myelin function. By recording electrically from oligodendrocytes and imaging their morphology we characterised the geometry and, for the first time, the resistance of myelin in the brain. This revealed differences between the properties of oligodendrocytes in two brain areas and established that the resistance of myelin is sufficiently high to prevent significant slowing of the nerve electrical signal by current leakage through the myelin.
authors.affiliation: Department of Physiology, University College London, London, UK.
authors.forename: Yamina
authors.initials: Y
authors.lastname: Bakiri
authors.forename: Ragnhildur
authors.initials: R
authors.lastname: Káradóttir
authors.forename: Lee
authors.initials: L
authors.lastname: Cossell
authors.forename: David
authors.initials: D
authors.lastname: Attwell
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001369:Axons / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000502:physiology*; D003198:Computer Simulation; D003337:Corpus Callosum / Q000166:cytology / Q000502:physiology*; D025802:Electric Capacitance; D017097:Electric Impedance; D054351:Electrical Synapses / Q000502:physiology; D055724:Electrophysiological Phenomena / Q000502:physiology*; D008959:Models, Neurological; D009186:Myelin Sheath / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D009836:Oligodendroglia / Q000166:cytology* / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley