title: Prognostic factors and oncologic outcome in 146 patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: Italian multicenter study S.I.T.I.L.O.
abstract: OBJECTIVE
  The present study was specifically designed to assess the major clinical and pathological variables of patients with colorectal peritoneal carcinomatosis in order to investigate whether currently used criteria appropriately select candidates for peritonectomy procedures (cytoreductive surgery) combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
  
  
  METHODS
  Preoperative, operative and follow-up data on 146 consecutive patients presenting with peritoneal carcinomatosis of colorectal origin and treated by surgical cytoreduction combined with HIPEC in 5 Italian Hospital and University Centers were prospectively entered in a common database. Univariate and multivariate analyses were used to assess the prognostic value of clinical and pathologic factors.
  
  
  RESULTS
  Over a minimum 24-month follow-up, the overall morbidity rate was 27.4% (mortality rate: 2.7%) and was directly related to the extent of surgery. Peritoneal cancer index (PCI), unfavorable peritoneal sites, synchronous or previously resected liver metastasis and the completeness of cytoreduction, all emerged as independent prognostic factors correlated with survival.
  
  
  CONCLUSIONS
  Until research provides more effective criteria for selecting patients based upon the biomolecular features of carcinomatosis, patients should be selected according to the existing independent prognostic variables.
authors.affiliation: Department of Surgery, San Giovanni Hospital, Via dell'Amba Aradam 9, 00184 Rome, Italy. francescocavaliere@fastwebnet.it
authors.forename: F
authors.initials: F
authors.lastname: Cavaliere
authors.forename: M
authors.initials: M
authors.lastname: De Simone
authors.forename: S
authors.initials: S
authors.lastname: Virzì
authors.forename: M
authors.initials: M
authors.lastname: Deraco
authors.forename: C R
authors.initials: CR
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Garofalo
authors.forename: F
authors.initials: F
authors.lastname: Di Filippo
authors.forename: D
authors.initials: D
authors.lastname: Giannarelli
authors.forename: M
authors.initials: M
authors.lastname: Vaira
authors.forename: M
authors.initials: M
authors.lastname: Valle
authors.forename: P
authors.initials: P
authors.lastname: Pilati
authors.forename: P
authors.initials: P
authors.lastname: Perri
authors.forename: M
authors.initials: M
authors.lastname: La Pinta
authors.forename: I
authors.initials: I
authors.lastname: Monsellato
authors.forename: F
authors.initials: F
authors.lastname: Guadagni
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D013505:Digestive System Surgical Procedures / Q000379:methods; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007558:Italy; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000628:therapy*; D011379:Prognosis; D016896:Treatment Outcome