title: The effects of postnatal estrogen therapy on brain development in preterm baboons.
abstract: OBJECTIVE
  Estrogen receptors are present within the fetal brain, suggesting that estrogens may exert an influence on cerebral development. Loss of placentally derived estrogen in preterm birth may impair development.
  
  
  METHODS
  Baboons were delivered at 125 days of gestation (term approximately 185 days), randomly allocated to receive estradiol (n = 10) or placebo (n = 8), and ventilated for 14 days. Brains were assessed for developmental and neuropathological parameters.
  
  
  RESULTS
  Body and brain weights were not different between groups, but the brain/body weight ratio was increased (P < .05) in estradiol-treated animals. There were no differences (P > .05) between groups in any neuropathological measure in either the forebrain or cerebellum. There were no intraventricular hemorrhages; 1 estradiol animal displayed ectactic vessels in the subarachnoid space.
  
  
  CONCLUSIONS
  Brief postnatal estradiol administration to primates does not pose an increased risk of injury or impaired brain development.
authors.affiliation: Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rees
authors.forename: Michelle
authors.initials: M
authors.lastname: Loeliger
authors.forename: Amy
authors.initials: A
authors.lastname: Shields
authors.forename: Philip W
authors.initials: PW
authors.lastname: Shaul
authors.forename: Donald
authors.initials: D
authors.lastname: McCurnin
authors.forename: Bradley
authors.initials: B
authors.lastname: Yoder
authors.forename: Terrie
authors.initials: T
authors.lastname: Inder
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D004958:Estradiol / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D007150:Immunohistochemistry; D016014:Linear Models; D010215:Papio; D047928:Premature Birth / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: D004958:Estradiol