title: Reduced mortality after allogeneic hematopoietic-cell transplantation.
abstract: BACKGROUND
  Over the past decade, advances have been made in the care of patients undergoing transplantation. We conducted a study to determine whether these advances have improved the outcomes of transplantation.
  
  
  METHODS
  We analyzed overall mortality, mortality not preceded by relapse, recurrent malignant conditions, and the frequency and severity of major complications of transplantation, including graft-versus-host disease (GVHD) and hepatic, renal, pulmonary, and infectious complications, among 1418 patients who received their first allogeneic transplants at our center in Seattle in the period from 1993 through 1997 and among 1148 patients who received their first allogeneic transplants in the period from 2003 through 2007. Components of the Pretransplant Assessment of Mortality (PAM) score were used in regression models to adjust for the severity of illness at the time of transplantation.
  
  
  RESULTS
  In the 2003-2007 period, as compared with the 1993-1997 period, we observed significant decreases in mortality not preceded by relapse, both at day 200 (by 60%) and overall (by 52%), the rate of relapse or progression of a malignant condition (by 21%), and overall mortality (by 41%), after adjustment for components of the PAM score. The results were similar when the analyses were limited to patients who received myeloablative conditioning therapy. We also found significant decreases in the risk of severe GVHD; disease caused by viral, bacterial, and fungal infections; and damage to the liver, kidneys, and lungs.
  
  
  CONCLUSIONS
  We found a substantial reduction in the hazard of death related to allogeneic hematopoietic-cell transplantation, as well as increased long-term survival, over the past decade. Improved outcomes appear to be related to reductions in organ damage, infection, and severe acute GVHD. (Funded by the National Institutes of Health.).
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Ted A
authors.initials: TA
authors.lastname: Gooley
authors.forename: Jason W
authors.initials: JW
authors.lastname: Chien
authors.forename: Steven A
authors.initials: SA
authors.lastname: Pergam
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Hingorani
authors.forename: Mohamed L
authors.initials: ML
authors.lastname: Sorror
authors.forename: Michael
authors.initials: M
authors.lastname: Boeckh
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Martin
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Sandmaier
authors.forename: Kieren A
authors.initials: KA
authors.lastname: Marr
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Appelbaum
authors.forename: Rainer
authors.initials: R
authors.lastname: Storb
authors.forename: George B
authors.initials: GB
authors.lastname: McDonald
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D001855:Bone Marrow Diseases / Q000401:mortality / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000401:mortality; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality*; D006801:Humans; D007223:Infant; D007239:Infections / Q000453:epidemiology / Q000209:etiology; D007674:Kidney Diseases / Q000453:epidemiology / Q000209:etiology; D007938:Leukemia / Q000401:mortality / Q000628:therapy*; D008107:Liver Diseases / Q000453:epidemiology / Q000209:etiology; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000628:therapy; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D009101:Multiple Myeloma / Q000401:mortality / Q000628:therapy; D009190:Myelodysplastic Syndromes / Q000628:therapy; D012008:Recurrence; D014184:Transplantation, Homologous / Q000401:mortality; D055815:Young Adult
chemical_list: D003404:Creatinine; D001663:Bilirubin