title: Serum retinol-binding protein-4 levels in polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in-vitro fertilization cycle.
abstract: OBJECTIVE
  To determine serum retinol-binding rotein 4 (RBP-4) levels in polycystic ovary syndrome (PCOS) patients undergoing controlled ovarian hyperstimulation (COH) for an in vitro fertilization-embryo transfer (IVF-ET) cycle and the possible correlation to COH variables.
  
  
  METHODS
  11 consecutive PCOS patients undergoing our routine IVF flexible multidose gonadotropin-releasing hormone (GnRH)-antagonist protocol. Blood was drawn three times during the COH cycle: (1) day 1 or 2 of menstruation, and prior to gonadotropin administration (Day-S) (Day-S); (2) day of or prior to human chorionic gonadotropin (hCG) administration (Day-hCG); and (3) day of ovum pick-up (Day-OPU). Levels of estradiol and serum RBP-4 were compared among the three time points. Serum RBP-4 was measured with a commercial immunoassay.
  
  
  RESULTS
  Results showed significantly lower levels of serum RBP-4 on Day-OPU and Day-hCG than on Day-S. Though significant correlations were observed between serum RBP-4 and body mass index, fasting glucose or glucose to insulin ratio, no correlations were found between serum RBP-4 and IVF treatment variables or pregnancy rate.
  
  
  CONCLUSIONS
  While serum RBP-4 decreases during COH for IVF, there is apparently no correlation of serum RBP-4 levels with IVF treatment variables or outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel. raoulo@barzi.health.gov.il
authors.forename: R
authors.initials: R
authors.lastname: Orvieto
authors.forename: V
authors.initials: V
authors.lastname: Shuhat
authors.forename: G
authors.initials: G
authors.lastname: Liberty
authors.forename: R
authors.initials: R
authors.lastname: Homburg
authors.forename: E Y
authors.initials: EY
authors.lastname: Anteby
authors.forename: R
authors.initials: R
authors.lastname: Nahum
authors.forename: J
authors.initials: J
authors.lastname: Rabinson
authors.forename: S
authors.initials: S
authors.lastname: Meltcer
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D008137:Longitudinal Studies; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D055815:Young Adult
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol