title: The association between inherited thrombophilias and pregnancy-related hypertension recurrence.
abstract: OBJECTIVE
  The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence.
  
  
  METHODS
  In this case-control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n = 41) and healthy, normotensive pregnancies delivered without any complication (n = 38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method.
  
  
  RESULTS
  Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6-1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations.
  
  
  CONCLUSIONS
  Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Dumlupinar Boulevard, 07070 Antalya, Turkey. imendilcioglu@yahoo.com
authors.forename: Inanc
authors.initials: I
authors.lastname: Mendilcioglu
authors.forename: Turker
authors.initials: T
authors.lastname: Bilgen
authors.forename: Yunus
authors.initials: Y
authors.lastname: Arikan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Keser
authors.forename: Mehmet
authors.initials: M
authors.lastname: Simsek
authors.forename: Aysen
authors.initials: A
authors.lastname: Timuragaoglu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000235:genetics*; D007557:Israel; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D017354:Point Mutation; D011247:Pregnancy; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000097:blood / Q000150:complications / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)