title: Novel drug delivery systems in topical treatment of psoriasis: rigors and vigors.
abstract: Psoriasis is a chronic inflammatory skin disorder that may drastically impair the quality of life of a patient. Among the various modes of treatments for psoriasis, topical therapy is most commonly used in majority of patients. The topical formulations based on conventional excipients could serve the purpose only to a limited extent. With the advent of newer biocompatible and biodegradable materials like phospholipids, and cutting-edge drug delivery technologies like liposomes, solid lipid nanoparticles (SLNs), microemulsions, and nanoemulsions, the possibility to improve the efficacy and safety of the topical products has increased manifold. Improved understanding of the dermal delivery aspects and that of designing and developing diverse carrier systems have brought in further novelty in this approach. Substantial efforts and the consequent publications, patents and product development studies on the subject are the matter of interest and review of this article. However, majority of the work is related to the preclinical studies and demands further clinical assessment in psoriasis patients.
authors.affiliation: Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India. drkatare@yahoo.com
authors.forename: Om Prakash
authors.initials: OP
authors.lastname: Katare
authors.forename: Kaisar
authors.initials: K
authors.lastname: Raza
authors.forename: Bhupinder
authors.initials: B
authors.lastname: Singh
authors.forename: Sunil
authors.initials: S
authors.lastname: Dogra
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000592:standards; D004337:Drug Carriers / Q000008:administration & dosage / Q000592:standards; D016503:Drug Delivery Systems / Q000379:methods / Q000592:standards* / Q000639:trends*; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D003879:Dermatologic Agents; D004337:Drug Carriers