title: Effects of exercise and physical activity on depression.
abstract: BACKGROUND
  Depression is a very prevalent mental disorder affecting 340 million people globally and is projected to become the leading cause of disability and the second leading contributor to the global burden of disease by the year 2020.
  
  
  OBJECTIVE
  In this paper, we review the evidence published to date in order to determine whether exercise and physical activity can be used as therapeutic means for acute and chronic depression. Topics covered include the definition, classification criteria and treatment of depression, the link between β-endorphin and exercise, the efficacy of exercise and physical activity as treatments for depression, properties of exercise stimuli used in intervention programs, as well as the efficacy of exercise and physical activity for treating depression in diseased individuals.
  
  
  CONCLUSIONS
  The presented evidence suggests that exercise and physical activity have beneficial effects on depression symptoms that are comparable to those of antidepressant treatments.
authors.affiliation: Department of Sport and Exercise Science, University of Thessaly, TEFAA Karies, Trikala 42100, Greece. pentinas@pe.uth.gr
authors.forename: P C
authors.initials: PC
authors.lastname: Dinas
authors.forename: Y
authors.initials: Y
authors.lastname: Koutedakis
authors.forename: A D
authors.initials: AD
authors.lastname: Flouris
mesh_terms: D003863:Depression / Q000523:psychology / Q000628:therapy*; D015444:Exercise / Q000502:physiology / Q000523:psychology*; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D001615:beta-Endorphin / Q000502:physiology*
chemical_list: D001615:beta-Endorphin