title: Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.
abstract: Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Md 21224, USA. mwillia1@jhmi.edu
authors.forename: Marlene S
authors.initials: MS
authors.lastname: Williams
authors.forename: Ethan J
authors.initials: EJ
authors.lastname: Weiss
authors.forename: Marc S
authors.initials: MS
authors.lastname: Sabatine
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Simon
authors.forename: Wadie F
authors.initials: WF
authors.lastname: Bahou
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Becker
authors.forename: Leslie V
authors.initials: LV
authors.lastname: Parise
authors.forename: Harold L
authors.initials: HL
authors.lastname: Dauerman
authors.forename: Patricia A
authors.initials: PA
authors.lastname: French
authors.forename: Susan S
authors.initials: SS
authors.lastname: Smyth
authors.forename: Richard C
authors.initials: RC
authors.lastname: Becker
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D015195:Drug Design; D004351:Drug Resistance / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D010641:Phenotype; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D010980:Platelet Membrane Glycoproteins / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
chemical_list: D010975:Platelet Aggregation Inhibitors; D010980:Platelet Membrane Glycoproteins