title: Ventilation strategy and its influence on the functional performance of lung grafts in an experimental model of single lung transplantation using non-heart-beating donors.
abstract: OBJECTIVE
  To compare the influence of two different ventilation strategies-volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV)-on the functional performance of lung grafts in a canine model of unilateral left lung transplantation using donor lungs harvested after three hours of normothermic cardiocirculatory arrest under mechanical ventilation.
  
  
  METHODS
  The study comprised 40 mongrel dogs, randomized into two groups: VCV and PCV. Of the 20 recipients, 5 did not survive the transplant, and 5 died before the end of the post-transplant assessment period. The remaining 10 survivors (5 in each group) were evaluated for 360 min after lung transplantation. The functional performance of the grafts was evaluated regarding respiratory mechanics, gas exchange, and lung graft histology.
  
  
  RESULTS
  There were no significant differences between the groups regarding respiratory mechanics (peak inspiratory pressure, plateau pressure, mean airway pressure, dynamic compliance, and static compliance) or gas exchange variables (PaO2, venous oxygen tension, PaCO2, venous carbon dioxide tension, and the arterial-venous oxygen content difference). The histopathological findings were consistent with nonspecific acute lung injury and did not differ between the groups.
  
  
  CONCLUSIONS
  This model of lung transplantation showed that the functional performance of lung grafts was not influenced by the ventilation strategy employed during the first six hours after reperfusion.
authors.affiliation: Department of Surgery, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Elaine Aparecida
authors.initials: EA
authors.lastname: Felix
authors.forename: Cristiano Feijó
authors.initials: CF
authors.lastname: Andrade
authors.forename: Paulo Francisco Guerreiro
authors.initials: PF
authors.lastname: Cardoso
authors.forename: Gabriela Cury
authors.initials: GC
authors.lastname: Thiesen
authors.forename: Ana Carolina Peçanha
authors.initials: AC
authors.lastname: Antonio
authors.forename: Lucas Krieger
authors.initials: LK
authors.lastname: Martins
authors.forename: Tiago Antonio
authors.initials: TA
authors.lastname: Tonietto
mesh_terms: D000818:Animals; D004285:Dogs; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D016040:Lung Transplantation / Q000379:methods / Q000502:physiology*; D023421:Models, Animal; D009926:Organ Preservation; D011897:Random Allocation; D012121:Respiration, Artificial / Q000379:methods*