title: Standardized in vitro drug release test for colloidal drug carriers using modified USP dissolution apparatus I.
abstract: BACKGROUND
  Recently the use of colloidal carriers as drug delivery systems is gaining more attention. Evaluation of the in vitro drug release is considered an important step during the development and quality control of such systems. Therefore, there is a need for a standard test technique to study in vitro drug release from colloidal systems.
  
  
  METHODS
  The glass basket dialysis method was performed by a modification to the USP dissolution apparatus I by replacing the baskets with glass cylinders closed at the lower end by dialysis membrane. This method was characterized for the essential test parameters and compared to the dialysis bags technique using different types of colloidal drug carriers, namely liposomes, polymeric, and lipid nanoparticles.
  
  
  RESULTS
  The method proved to be more discriminating than the conventional dialysis bag method and allowed for better comparison between different formulation parameters or experimental conditions. In general, the design is easy to perform, simple, and available in all pharmaceutical laboratories under the same setup.
  
  
  CONCLUSIONS
  The described method is a step toward standardized dissolution tests on colloidal drug delivery systems and the possible comparability of results.
authors.affiliation: Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.
authors.forename: Mona M A
authors.initials: MM
authors.lastname: Abdel-Mottaleb
authors.forename: Alf
authors.initials: A
authors.lastname: Lamprecht
mesh_terms: D003102:Colloids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D007052:Ibuprofen / Q000008:administration & dosage; D008055:Lipids / Q000737:chemistry; D008081:Liposomes; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003102:Colloids; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D011108:Polymers; D007052:Ibuprofen