title: Progression rate from new-onset pre-hypertension to hypertension in Korean adults.
abstract: BACKGROUND
  There are limited studies conducted in Asia to investigate the progression rate to hypertension (HTN). This study was done to estimate the progression rate of new-onset pre-HTN (PreHTN) to HTN during an 8-year follow-up period, and to compare the impact of PreHTN on progression to HTN.
  
  
  RESULTS
  A total of 49,228 participants, aged 30 to 54 years with new-onset PreHTN at baseline (1994-1996) from a biennial national medical exam were enrolled and followed up every 2 years until 2004. The incidence rate recorded at each interval and the cumulative incidence rate of HTN were analyzed. Hazard ratio of high-normal and high blood pressure (BP) in men and women was calculated. The cumulative incidence rate for high-normal BP was 27.6% and 26.4% at 2-year follow-up, increased to respectively 64.1% and 55.8% in men and women at the 8-year follow-up. Compared to optimal BP, hazard ratios for men with high-normal BP across all age groups were 3- to 4-fold higher at 2-year, and 2- to 3-fold higher at 8-year follow-up. Hazard ratios for women were about 6-fold higher at 2-year and around 4-fold higher at 8-year follow-up.
  
  
  CONCLUSIONS
  New PreHTN was a significant predisposing factor for future HTN, in young adults and the effect is more prominent in women.
authors.affiliation: Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Soo Jeong
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jakyoung
authors.initials: J
authors.lastname: Lee
authors.forename: Chung Mo
authors.initials: CM
authors.lastname: Nam
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Jee
authors.forename: Il Soo
authors.initials: IS
authors.lastname: Park
authors.forename: Kyung Jong
authors.initials: KJ
authors.lastname: Lee
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000328:Adult; D017677:Age Distribution; D044466:Asian People / Q000706:statistics & numerical data*; D001794:Blood Pressure; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000208:ethnology* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D058246:Prehypertension / Q000208:ethnology* / Q000503:physiopathology; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D013997:Time Factors