title: A comparison of pregnancy rates following fresh and frozen embryo transfer according to the use of leuprolide acetate vs ganirelix vs cetrorelix.
abstract: OBJECTIVE
  To determine if controlled ovarian hyperstimulation (COH) regimens using the gonadotropin releasing hormone (GnRH) agonist leuprolide acetate result in higher pregnancy and implantation rates than COH regimens using the GnRH antagonists cetrorelix or ganirelix following fresh and frozen embryo transfer.
  
  
  METHODS
  Retrospective analysis was performed evaluating the pregnancy rates with the first fresh and first frozen embryo transfer cycles according to which protocol was used. A haphazard decision was made on which protocol to use. Women were required to be < 40 years of age and have had > or = 5 eggs retrieved.
  
  
  RESULTS
  Significantly lower implantation rates were seen with ganirelix compared to leuprolide acetate or cetrorelix.
  
  
  CONCLUSIONS
  These data should hopefully encourage interest in a prospective study to determine if conclusions about the inferiority of ganirelix are not merely fortuitous.
authors.affiliation: The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: C
authors.initials: C
authors.lastname: Wilson
authors.forename: J K
authors.initials: JK
authors.lastname: Choe
authors.forename: J
authors.initials: J
authors.lastname: Amui
authors.forename: B
authors.initials: B
authors.lastname: Katsoff
mesh_terms: D000328:Adult; D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide; C061018:ganirelix; C062876:cetrorelix