title: The essence of senescence.
abstract: Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.
authors.affiliation: Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuilman
authors.forename: Chrysiis
authors.initials: C
authors.lastname: Michaloglou
authors.forename: Wolter J
authors.initials: WJ
authors.lastname: Mooi
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Peeper
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002477:Cells / Q000166:cytology; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology
chemical_list: D015415:Biomarkers