title: Quantitative analysis of tumor vascular structure after drug treatment.
abstract: This paper reports a method that aims to quantify the changes of tumour vascular structure as a result of drug treatment. The measures we have investigated to date include: vessel radii, inter-branch lengths, tortuosity and branch angles. We show that the distribution of vessel radii is better modelled as a gamma distribution as opposed to the log-normal distribution asserted by other researchers. We propose a new metric based on multiple linear regression to measure vascular tortuosity. We report statistical analyses which confirm that (as expected), at different significance levels, all the drugs we have tested (FTI, Iressa, Nelfinavir and PI-103) have positive effects in improving a tumour's vascular network. In each case, the changes are quantified.
authors.affiliation: Wolfson Medical Vision Laboratory, Dept of Engineering Science, University of Oxford, UK.
authors.forename: Po
authors.initials: P
authors.lastname: Wang
authors.forename: Catherine
authors.initials: C
authors.lastname: Kelly
authors.forename: Ann
authors.initials: A
authors.lastname: Harvey
authors.forename: Naseer
authors.initials: N
authors.lastname: Qayum
authors.forename: Ruth J
authors.initials: RJ
authors.lastname: Muschel
authors.forename: Michael
authors.initials: M
authors.lastname: Brady
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001160:Arterioles / Q000187:drug effects* / Q000503:physiopathology*; D003198:Computer Simulation; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy* / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D000970:Antineoplastic Agents