title: Synthesis and antimycobacterial activity of a series of ferrocenyl derivatives.
abstract: In this work we reported the synthesis and evaluation of Mycobacterium tuberculosis activities in vitro of a series of twenty five ferrocenyl derivatives: ferrocenyl amides derived from nicotinamide and pyrazinamide, ferrocenyl pyridinyl, quinolyl and acridinylhydrazones. In particular ferrocenyl acylhydrazones 7 and 8 and ferrocenylquinoxaline amide 57 showed interesting antimycobacterial activities.
authors.affiliation: Université Lille Grand Nord, Université de Lille 1, Unité de Catalyse et de Chimie du Solide, UMR CNRS 8181, ENSCL, B.P. 108, 59652 Villeneuve d'Ascq, France.
authors.forename: Gabin Mwande
authors.initials: GM
authors.lastname: Maguene
authors.forename: Jouda
authors.initials: J
authors.lastname: Jakhlal
authors.forename: Melissa
authors.initials: M
authors.lastname: Ladyman
authors.forename: Aurélie
authors.initials: A
authors.lastname: Vallin
authors.forename: Dimby Andrianina
authors.initials: DA
authors.lastname: Ralambomanana
authors.forename: Till
authors.initials: T
authors.lastname: Bousquet
authors.forename: Jeanne
authors.initials: J
authors.lastname: Maugein
authors.forename: Jacques
authors.initials: J
authors.lastname: Lebibi
authors.forename: Lydie
authors.initials: L
authors.lastname: Pélinski
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000075163:Metallocenes; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009536:Niacinamide / Q000737:chemistry; D011718:Pyrazinamide / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D009536:Niacinamide; D011718:Pyrazinamide; C004998:ferrocene