title: Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi.
abstract: The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca(2+)-binding sites, and mediates the effects of cytosolic Ca(2+). Minute changes in free intracellular Ca(2+) are quickly transformed into changes in the activity of several kinases including calcium/calmodulin-dependent protein kinases (Ca(2+)/CaMKs) that are involved in regulating many eukaryotic cell functions. However, our current knowledge of NCS-1 and Ca(2+)/CaMKs comes mostly from studies of the mammalian enzymes. Thus far very few fungal homologues of NCS-1 and Ca(2+)/CaMKs have been characterized and little is known about their cellular roles. In this minireview, we describe the known sequences, interactions with target proteins and cellular roles of NCS-1 and Ca(2+)/CaMKs in fungi.
authors.affiliation: Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, India. ranjantamuli@iitg.ernet.in
authors.forename: Ranjan
authors.initials: R
authors.lastname: Tamuli
authors.forename: Ravi
authors.initials: R
authors.lastname: Kumar
authors.forename: Rekha
authors.initials: R
authors.lastname: Deka
mesh_terms: D000595:Amino Acid Sequence; D020013:Calcium Signaling / Q000502:physiology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D020832:EF Hand Motifs / Q000235:genetics / Q000502:physiology; D005658:Fungi / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D051580:Neuronal Calcium-Sensor Proteins / Q000235:genetics / Q000378:metabolism*; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D016415:Sequence Alignment
chemical_list: D051580:Neuronal Calcium-Sensor Proteins; D009479:Neuropeptides; C101464:frequenin calcium sensor proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases