title: Grand challenge commentary: The chemistry of a dynamic genome.
abstract: In the postsequencing era, chemical biology is uniquely situated to investigate genomic DNA alterations arising through epigenetic modifications, genetic rearrangements or active mutation. These transformations significantly expand nature's diversity and may profoundly alter our view of DNA's coding potential.
authors.affiliation: Division of Infectious Disease, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. rkohli@upenn.edu
authors.forename: Rahul M
authors.initials: RM
authors.lastname: Kohli
mesh_terms: D004247:DNA / Q000737:chemistry*; D044127:Epigenesis, Genetic; D015321:Gene Rearrangement; D016678:Genome / Q000235:genetics*; D023281:Genomics / Q000639:trends*; D009154:Mutation / Q000502:physiology
chemical_list: D004247:DNA