title: 3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance.
abstract: 3G11 is a sialylated carbohydrate epitope of the disialoganglioside molecule expressed on mouse CD4(+) T cells. Recent research showed that 3G11 expression is related to the modulation of T cell function, i.e., 3G11(-) T cells exhibit anergic/Treg characteristics and efficiently inhibit autoimmunity in the central nervous system. The relationship between 3G11 expression and immune tolerance is summarized in this literature review.
authors.affiliation: Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA 19107, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.forename: Guang-Xian
authors.initials: GX
authors.lastname: Zhang
authors.forename: Abdolmohamad
authors.initials: A
authors.lastname: Rostami
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002490:Central Nervous System / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000096:biosynthesis; D005732:Gangliosides / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*
chemical_list: D000954:Antigens, Surface; D018984:Epitopes, T-Lymphocyte; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D005732:Gangliosides; C509654:antigen 3G11, mouse; C025447:sialogangliosides