title: Dynein at odd angles?
abstract: Cytoplasmic dynein drives vesicular transport from the periphery to the cell body of neurons. Missense mutations in the dynein tail domain cause neurodegenerative disease in mouse models. new data on the effect of one such dynein mutation provide insight into the intramolecular communication and flexible stepping of this essential cellular motor.
authors.forename: Adam G
authors.initials: AG
authors.lastname: Hendricks
authors.forename: Jacob E
authors.initials: JE
authors.lastname: Lazarus
authors.forename: Erika L F
authors.initials: EL
authors.lastname: Holzbaur
mesh_terms: D000818:Animals; D004398:Dyneins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D009474:Neurons / Q000378:metabolism
chemical_list: D004398:Dyneins