title: A miniaturized device for wireless FSCV monitoring of dopamine in an ambulatory subject.
abstract: This paper reports on a miniaturized device for wireless monitoring of extracellular dopamine levels in the brain of an ambulatory rat using fast-scan cyclic voltammetry at a carbon-fiber microelectrode. The device comprises integrated circuitry for neurochemical recording fabricated in 0.5-microm double-poly triple-metal CMOS technology, which is assembled and packaged on a miniature rigid-flex substrate together with a few external components for supply generation, biasing, and chip programming. The device operates from a single 3-V battery, weighs 2.3 g (including the battery), and upon implantation successfully captures the effects of the psychostimulant amphetamine on electrically and non-electrically evoked dopamine neurotransmission in the caudateputamen region of an ambulatory rat's forebrain.
authors.affiliation: West Wireless Health Institute, La Jolla, CA 92037, USA.
authors.forename: Masoud
authors.initials: M
authors.lastname: Roham
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Covey
authors.forename: David P
authors.initials: DP
authors.lastname: Daberkow
authors.forename: Eric S
authors.initials: ES
authors.lastname: Ramsson
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Howard
authors.forename: Paul A
authors.initials: PA
authors.lastname: Garris
authors.forename: Pedram
authors.initials: P
authors.lastname: Mohseni
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D008297:Male; D008904:Miniaturization / Q000295:instrumentation*; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D059015:Wireless Technology / Q000295:instrumentation*
chemical_list: D000661:Amphetamine; D004298:Dopamine