title: [The role of the incidence of genetic abnormalities on the onset and on the results of the surgical repair of varicocele].
abstract: OBJECTIVE
  The purpose of this study is to identify possible implications of the presence of genetic abnormalities of male infertility evaluating the suitable response to surgical repair of varicocele, comparing the clinical characteristics of infertile men with the presence or absence of genetic abnormalities.
  
  
  METHODS
  It has been evaluated the incidence of chromosomal abnormalities and microdeletions of the Y chromosome, through the use of techniques of cytogenetics and molecular biology in patients with varicocele of grade III, preoperatively submitted to physical examination and U.S. Doppler examination, and in which the seminal and hormonal parameters for the diagnosis of oligospermia didn't have meaningful differences. Six months after the surgical correction of the varicocele a comparison has been performed between the response to surgical repair between patients of group A (free of genetic defects) and patients of group B (with genetic defects) through the reevaluation of semen parameters and of the U.S. Doppler.
  
  
  RESULTS
  26.6% of patients had genetic defects suggesting a significant association of genetic alterations in varicocele. Moreover in the group without genetic abnormality a better response to varicocelectomia has been observed.
  
  
  CONCLUSIONS
  We found that a high percentage of examined patients showed genetic defects such as chromosomal aberrations (insertions, deletions, inversions or translocations) or Y chromosome microdeletions. As these genetic alterations are associated with infertility, genetic screening in patients with varicocele may represent a useful tool for diagnosis and prognosis of some cases of male infertility.
authors.affiliation: Università degli Studi di Messina, Policlinico Universitario G. Martino, Messina. rossitt@unime.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Rossitto
authors.forename: Luciana
authors.initials: L
authors.lastname: Rigoli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Procopio
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciccolo
mesh_terms: D000328:Adult; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D015994:Incidence; D007248:Infertility, Male / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery*; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index; D012802:Sicily / Q000453:epidemiology; D014646:Varicocele / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery*