title: Multimodal target correction by local bone registration: a PET/CT evaluation.
abstract: PET/CT guidance for percutaneous interventions allows biopsy of suspicious metabolically active bone lesions even when no morphological correlation is delineable in the CT images. Clinical use of PET/CT guidance with conventional step-by-step technique is time consuming and complicated especially in cases in which the target lesion is not shown in the CT image. Our recently developed multimodal instrument guidance system (IGS) for PET/CT improved this situation. Nevertheless, bone biopsies even with IGS have a trade-off between precision and intervention duration which is proportional to patient and personnel exposure to radiation. As image acquisition and reconstruction of PET may take up to 10 minutes, preferably only one time consuming combined PET/CT acquisition should be needed during an intervention. In case of required additional control images in order to check for possible patient movements/deformations, or to verify the final needle position in the target, only fast CT acquisitions should be performed. However, for precise instrument guidance accounting for patient movement and/or deformation without having a control PET image, it is essential to be able to transfer the position of the target as identified in the original PET/CT to a changed situation as shown in the control CT.
authors.affiliation: Institute for Surgical Technology & Biomechanics, Bern University, Switzerland.
authors.forename: Thiago
authors.initials: T
authors.lastname: Oliveira-Santos
authors.forename: Thilo
authors.initials: T
authors.lastname: Weitzel
authors.forename: Bernd
authors.initials: B
authors.lastname: Klaeser
authors.forename: Thomas
authors.initials: T
authors.lastname: Krause
authors.forename: Lutz-Peter
authors.initials: LP
authors.lastname: Nolte
authors.forename: Stefan
authors.initials: S
authors.lastname: Weber
authors.forename: Mauricio
authors.initials: M
authors.lastname: Reyes
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D012015:Reference Standards; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*