title: Noninflammatory cerebral vasculopathy associated with recurrent ischemic strokes.
abstract: Recurrent ischemic strokes often have uncommon causes in young adults. Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subsequent brain biopsy revealed a distinctive histopathological pattern of abnormal perivascular collagen deposition without inflammation. Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail.
authors.affiliation: Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. mckinnjs@umdnj.edu
authors.forename: James S
authors.initials: JS
authors.lastname: McKinney
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Raser
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Guzman
authors.forename: William W
authors.initials: WW
authors.lastname: Schlaepfer
authors.forename: Brett L
authors.initials: BL
authors.lastname: Cucchiara
authors.forename: Steven R
authors.initials: SR
authors.lastname: Messé
authors.forename: Lauren H
authors.initials: LH
authors.lastname: Sansing
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kasner
mesh_terms: D000328:Adult; D001706:Biopsy; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology*; D002533:Cerebral Angiography; D006801:Humans; D008297:Male; D012008:Recurrence; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*