title: [Effect of topical corticosteroids on expression of PKC, Bcl-2 and Bax in nasal polyps].
abstract: OBJECTIVE
  To study the effect of intranasal glucosteroid on the expression of PKC, Bcl-2 and Bax in nasal polyps.
  
  
  METHODS
  The expression of PKC, Bcl-2 protein and Bax were detected with immunohistochemistry in nasal polyps from the patients (n=16) pre and post treated for 4 weeks with intranasal glucosteroid. And which compared with normal mucous membrane of inferior turbinate concha.
  
  
  RESULTS
  The PKC and Bcl-2 protein expressed significantly higher in the pretreated patients (P < 0.01), which were significant reduced in the post treated patients compared with pretreated ones. The expression of Bax protein significantly higher in the post treated patients (P < 0.05).
  
  
  CONCLUSIONS
  Our findings indicated that abnormal expression of apoptosis related genes in nasal polyps tissues might play an important role in the occurrence and progression of nasal polyps. The treatment of intranasal glucosteroid may regulate the expression of apoptosis related genes.
authors.affiliation: Department of Otorhinolaryngology, the Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050000, China. rxm1966@sina.com
authors.forename: Xiumin
authors.initials: X
authors.lastname: Ren
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Yang
authors.forename: Naichao
authors.initials: N
authors.lastname: Duan
authors.forename: Xinxia
authors.initials: X
authors.lastname: Jiang
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D055815:Young Adult; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: C494826:BAX protein, human; D005938:Glucocorticoids; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D011493:Protein Kinase C