title: [Dynamics of autoimmune myocarditis development in rats].
abstract: The development of autoimmune myocarditis in rats after a single hypodermic injection of rat myosin mixed with a complete Freund's adjuvant (CFA) (400 microg/kg in 200 microl) was studied. The rats from the control group were injected with only CFA. The titer of antibodies to myosin, infiltration of lymphocytes into the myocardium, ultrastructural damage of myofibrils, mitochondria, and nuclei of cardiomyocytes were maximally pronounced on days 14-21 after the immunization with myosin, which indicates a peak of the inflammatory reaction. The content of nitrites and nitrates in the blood serum and myocardium of immunized rats were also studied. A certain contribution to the development of the inflammation is made by CFA: in rats injected with only CFA, morphological signs of myocarditis were found, but to a much lesser degree than in the group immunized with myosin.
authors.forename: S A
authors.initials: SA
authors.lastname: Gavrilova
authors.forename: M P
authors.initials: MP
authors.lastname: Morozova
authors.forename: A K
authors.initials: AK
authors.lastname: Kniazhentseva
authors.forename: L S
authors.initials: LS
authors.lastname: Pogodina
authors.forename: A B
authors.initials: AB
authors.lastname: Postnikov
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Chentsov
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D024722:Cardiac Myosins / Q000008:administration & dosage* / Q000276:immunology; D003627:Data Interpretation, Statistical; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005620:Freund's Adjuvant / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D009205:Myocarditis / Q000097:blood / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000648:ultrastructure*; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D051381:Rats
chemical_list: D001323:Autoantibodies; D009566:Nitrates; D009573:Nitrites; D005620:Freund's Adjuvant; D024722:Cardiac Myosins