title: [Current status of Akt in non-small cell lung cancer].
abstract: Lung cancer is one of the most common malignant tumors in the world, but its pathogenesis has still been remaining confusing. As an important protein in several signaling pathways, Akt has been identified to play a major role in the growth, proliferation, apoptosis and invasion of tumor cells. This paper is to review the effects of Akt, together with PDK1, Raf-1 and p70S6K, which are upstream and downstream regulatory molecules of Akt, and provide a new basis for the pathogenesis of non-small cell lung cancer.
authors.affiliation: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Bojiang
authors.initials: B
authors.lastname: Chen
authors.forename: Weimin
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051057:Proto-Oncogene Proteins c-akt