title: Multiscale systems modeling of the tetralogy of Fallot.
abstract: This paper provides a first description of a multiscale systems modeling approach applied to the congenital birth defect known as the tetralogy of Fallot. The multiscale approach adopted owes a lot to the effort of the world-wide physiome consortium and the work of research groups within the European Union on the Virtual Physiological Human. Both a spatial scale and time scale are used to establish the systems boundaries of the application. The tetralogy of Fallot includes up to four simultaneously occurring anatomic abnormalities that underpin the defect. The use of finite state machines and cellular automata pave the way to understand the processes in time and space that contribute to the defect.
authors.affiliation: Department of Electronic and Electrical Engineering, Loughborough University, UK. R.Summers@lboro.ac.uk
authors.forename: Ron
authors.initials: R
authors.lastname: Summers
authors.forename: Tariq
authors.initials: T
authors.lastname: Abdulla
authors.forename: Ryan
authors.initials: R
authors.lastname: Imms
authors.forename: Guy
authors.initials: G
authors.lastname: Carrault
authors.forename: Alfredo
authors.initials: A
authors.lastname: Hernandez
authors.forename: Lucile
authors.initials: L
authors.lastname: Houyel
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Schleich
mesh_terms: D003198:Computer Simulation; D047108:Embryonic Development; D006801:Humans; D008953:Models, Anatomic; D008954:Models, Biological; D013771:Tetralogy of Fallot / Q000196:embryology* / Q000473:pathology / Q000503:physiopathology*