title: Clinical relevance of changes in bone metabolism in inflammatory bowel disease.
abstract: Low bone mineral density is an established, frequent, but often neglected complication in patients with inflammatory bowel disease (IBD). Data regarding the diagnosis, therapy and follow-up of low bone mass in IBD has been partially extrapolated from postmenopausal osteoporosis; however, the pathophysiology of bone loss is altered in young patients with IBD. Fracture, a disabling complication, is the most important clinical outcome of low bone mass. Estimation of fracture risk in IBD is difficult. Numerous risk factors have to be considered, and these factors should be weighed properly to help in the identification of the appropriate patients for screening. In this editorial, the authors aim to highlight the most important clinical aspects of the epidemiology, prevention, diagnosis and treatment of IBD-related bone loss.
authors.forename: Pal
authors.initials: P
authors.lastname: Miheller
authors.forename: Katalin
authors.initials: K
authors.lastname: Lorinczy
authors.forename: Peter-Laszlo
authors.initials: PL
authors.lastname: Lakatos
mesh_terms: D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D050723:Fractures, Bone / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D008403:Mass Screening; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome