title: Performance of estimated glomerular filtration rate prediction equations in preeclamptic patients.
abstract: Accurate estimation of the glomerular filtration rate (GFR) in patients with preeclampsia requires the collection of a 24-hour urine and can have important therapeutic and diagnostic implications. This procedure is often difficult or impossible to accomplish in this patient group. In this study, the Cockcroft-Gault, the Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas were evaluated for their accuracy in determining GFR in the setting of preeclampsia. The estimated GFRs calculated from the above formulas were compared with the creatinine clearance values obtained from a 24-hour urine collections in 543 preeclamptic patients recruited from several large hospitals. Additionally, a set of new equations, preeclampsia GFR (PGFR), based on ethnicity, was created. The Cockcroft-Gault, MDRD, and CKD-EPI formulas were inaccurate in predicting GFR and both were significantly less accurate than PGFR. The latter formula provided an estimated GFR that was much closer to the creatinine clearance. Current GFR estimation equations based on serum creatinine values in nonpregnant patients are not reliable measures of renal function in patients with preeclampsia. The use of a new formula (PGFR) is recommended.
authors.affiliation: Department of Medicine (Section of Nephrology), Tulane University School of Medicine, New Orleans, Louisiana.
authors.forename: Arnold B
authors.initials: AB
authors.lastname: Alper
authors.forename: Yeonjoo
authors.initials: Y
authors.lastname: Yi
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Rahman
authors.forename: Larry S
authors.initials: LS
authors.lastname: Webber
authors.forename: Laura
authors.initials: L
authors.lastname: Magee
authors.forename: Peter
authors.initials: P
authors.lastname: von Dadelszen
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pridjian
authors.forename: Abimbola
authors.initials: A
authors.lastname: Aina-Mumuney
authors.forename: George
authors.initials: G
authors.lastname: Saade
authors.forename: Jamie
authors.initials: J
authors.lastname: Morgan
authors.forename: Bahij
authors.initials: B
authors.lastname: Nuwayhid
authors.forename: Michael
authors.initials: M
authors.lastname: Belfort
authors.forename: Jules
authors.initials: J
authors.lastname: Puschett
mesh_terms: D000328:Adult; D001741:Black or African American; D000465:Algorithms; D044466:Asian People; D003404:Creatinine / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016014:Linear Models; D011225:Pre-Eclampsia / Q000208:ethnology / Q000503:physiopathology* / Q000652:urine; D011247:Pregnancy; D015203:Reproducibility of Results; D044465:White People; D055815:Young Adult
chemical_list: D003404:Creatinine