title: The study on the preparation process of PEG pellets by vibration nozzle method.
abstract: BACKGROUND
  Uniform size beads can be easily produced by vibration nozzle method.
  
  
  OBJECTIVE
  In this article, the pellets of polyethylene glycol are prepared by a vibration nozzle machine. Thickness of nozzle wall, rotation speed of stirrer, and voltage of excitation are discussed in this article.
  
  
  CONCLUSIONS
  A nozzle wall of thickness ≤0.1 mm is applied to decrease the adherence of jet. The stirring device with 20 rotations/min on the upper side of condensed column is used to disperse unsolidified polyethylene glycol pellets. The effect of parameters including vibration frequency f, jet velocity v, and voltage of excitation V on the average diameter d and standard deviation SD% are investigated by response surface methodology and Weber equation. A very good linear regression between d and v/f is presented under optimum V (in this article V = 3.0 V). Both high v and low SD% can also be obtained by optimum V.
authors.affiliation: College of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin, PR China.
authors.forename: Mingxia
authors.initials: M
authors.lastname: He
authors.forename: Haibin
authors.initials: H
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Qing
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016014:Linear Models; D011092:Polyethylene Glycols / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D014732:Vibration
chemical_list: D004337:Drug Carriers; D011092:Polyethylene Glycols