title: Synthesis and properties of chiral thioureas bearing an additional function at a remote position tethered by a 1,5-disubstituted triazole.
abstract: The synthesis and properties of multifunctional thioureas bearing a variety of functional groups at a position remote from the thiourea moiety are described. A 1,5-disubstituted triazole tether connected with a thiourea and another functional group was synthesized via ruthenium catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as asymmetric catalysts and probes for the mechanistic elucidation of the course of the Michael reaction of an α,ß-unsaturated imide.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto, Japan. kay-t@pharm.kyoto-u.ac.jp
authors.forename: Kiyosei
authors.initials: K
authors.lastname: Takasu
authors.forename: Takumi
authors.initials: T
authors.lastname: Azuma
authors.forename: Iderbat
authors.initials: I
authors.lastname: Enkhtaivan
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Takemoto
mesh_terms: D015394:Molecular Structure; D013237:Stereoisomerism; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D014230:Triazoles; D013890:Thiourea