title: Labdane diterpenoids and shikimic acid derivatives from Araucaria cunninghamii.
abstract: Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ester (3), and 5-(Z)-coumaroyloxyquinic acid N-butyl ester (4). Compounds 1 and 6 exhibited inhibitory activity against Escherichia coli, and compound 1 also exhibited moderate activity against human leukemia cells (HL-60) and human hepatoma cells (SMMC-7721) with IC₅₀ values of 8.90 and 11.53 µM, respectively.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Chen
authors.forename: Li-Qiong
authors.initials: LQ
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Hua
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012765:Shikimic Acid / Q000737:chemistry / Q000494:pharmacology*; D064028:Tracheophyta / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts; C433017:labdane; D012765:Shikimic Acid