title: Assessing the impact of waterborne and dietborne cadmium toxicity on susceptibility risk for rainbow trout.
abstract: The purpose of this study was to use a risk-based integrated-scale toxicological model to examine the impact of waterborne and dietborne cadmium (Cd) toxicity on rainbow trout (Oncorhynchus mykiss) susceptibility appraised with recent published data. A probabilistic assessment model was performed to estimate Cd susceptibility risk. The dose-response models were constructed based on two endpoints of % Cd in metabolically active pool (MAP) and susceptibility time that causes 50% effect (ST50). We further constructed an elimination-detoxification-recovery scheme to enhance the model predictive ability. We found a 95% probability of % Cd in gill and liver MAP exceeding 47-49% and it was likely (70% probability) to have exceeded 52-55%, but it was unlikely (30% probability) to have exceeded 56-60%. In contrast to gill and liver, gut had a relative lower Cd susceptibility risk (15-17% Cd in MAP) with a longer ST50. We suggested that the proposed probabilistic risk assessment framework can incorporate the elimination-detoxification-recovery scheme to help government based biomonitoring and bioassessment programs to prevent potential aquatic ecosystems and human health consequences.
authors.affiliation: Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, 10617, Taiwan, ROC. cmliao@ntu.edu.tw
authors.forename: Chung-Min
authors.initials: CM
authors.lastname: Liao
authors.forename: Yun-Ru
authors.initials: YR
authors.lastname: Ju
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Chen
authors.forename: Bo-Ching
authors.initials: BC
authors.lastname: Chen
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005618:Fresh Water / Q000737:chemistry; D007700:Kinetics; D008954:Models, Biological; D015233:Models, Statistical; D017686:Oncorhynchus mykiss; D018570:Risk Assessment; D012307:Risk Factors; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014877:Water Pollution, Chemical / Q000706:statistics & numerical data*
chemical_list: D014874:Water Pollutants, Chemical; D002104:Cadmium