title: Antiretroviral pharmacology: special issues regarding pregnant women and neonates.
abstract: Antiretrovirals may be used in pregnant women infected with the HIV and their newborns both for treatment of maternal HIV disease and for prevention of mother-to-child transmission of HIV. More than 25 antiretroviral agents in 5 classes have been approved, with new drugs and classes in development. This article reviews current knowledge of the pharmacology of these drugs during pregnancy and in the newborn period, highlighting those pharmacologic issues critical to the safe and effective use of antiretrovirals in these populations.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Boston University School of Medicine, 771 Albany Street - Dowling 4111, Boston, MA 02118, USA. markm@bu.edu
authors.forename: Mark
authors.initials: M
authors.lastname: Mirochnick
authors.forename: Brookie M
authors.initials: BM
authors.lastname: Best
authors.forename: Diana F
authors.initials: DF
authors.lastname: Clarke
mesh_terms: D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D036861:Delivery, Obstetric; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008895:Milk, Human / Q000378:metabolism; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology*; D013723:Teratogens; D014018:Tissue Distribution
chemical_list: D044966:Anti-Retroviral Agents; D013723:Teratogens