title: [Early repolarization syndrome and recurrent syncope in two Chinese pedigrees].
abstract: OBJECTIVE
  to investigate the clinical characteristics in two families with early repolarization syndrome (ERS) and recurrent syncope.
  
  
  METHODS
  all family members including the probands were screened with routine clinical examination, electrocardiography, echocardiography, Holter recording, chest x-ray, head-up tilt test and blood biochemistry.
  
  
  RESULTS
  there was no clinical evidence of organic heart disease in all members from the two families. Proband 1 showed recurrent syncope, ERS and repeated torsade de pointes ventricular tachycardia and ventricular fibrillation were documented with resting ECG. ERS was detected in one brother, one nephew and one son from him and all were free of cardiac events including syncope, cardiac arrest and sudden cardiac death. Proband 2 showed recurrent syncope, ERS and ST segment arched upward elevation in V(1)-V(3) were documented by ECG. His father suffered sudden cardiac death at the age of 65 and asymptomatic ERS was detected in one of his nephew.
  
  
  CONCLUSIONS
  ERS is not always linked with benign clinical course and can sometimes lead to repeated syncope, torsade de pointes ventricular tachycardia and ventricular fibrillation. Pedigree research is of importance for ERS.
authors.affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhen-ni
authors.initials: ZN
authors.lastname: TAN
authors.forename: Wei
authors.initials: W
authors.lastname: DENG
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: LUO
authors.forename: Heng
authors.initials: H
authors.lastname: LI
authors.forename: Shao-xi
authors.initials: SX
authors.lastname: SUN
authors.forename: Su-rong
authors.initials: SR
authors.lastname: MENG
authors.forename: Ding-li
authors.initials: DL
authors.lastname: XU
authors.forename: Jian
authors.initials: J
authors.lastname: PENG
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000235:genetics*; D044466:Asian People; D006801:Humans; D008297:Male; D010375:Pedigree; D012008:Recurrence; D013575:Syncope / Q000235:genetics* / Q000503:physiopathology*; D013577:Syndrome