title: Laminin database: a tool to retrieve high-throughput and curated data for studies on laminins.
abstract: The Laminin(LM)-database, hosted at http://www.lm.lncc.br, is the first database focusing a non-collagenous extracellular matrix protein family, the LMs. Part of the knowledge available in this website is automatically retrieved, whereas a significant amount of information is curated and annotated, thus placing LM-database beyond a simple repository of data. In its home page, an overview of the rationale for the database is seen and readers can access a tutorial to facilitate navigation in the website, which in turn is presented with tabs subdivided into LMs, receptors, extracellular binding and other related proteins. Each tab opens into a given LM or LM-related molecule, where the reader finds a series of further tabs for 'protein', 'gene structure', 'gene expression' and 'tissue distribution' and 'therapy'. Data are separated as a function of species, comprising Homo sapiens, Mus musculus and Rattus novergicus. Furthermore, there is specific tab displaying the LM nomenclatures. In another tab, a direct link to PubMed, which can be then consulted in a specific way, in terms of the biological functions of each molecule, knockout animals and genetic diseases, immune response and lymphomas/leukemias. LM-database will hopefully be a relevant tool for retrieving information concerning LMs in health and disease, particularly regarding the hemopoietic system.
authors.affiliation: Bioinformatics Laboratory, National Laboratory of Scientific Computation, Ave. Getúlio Vargas 333, 25651-075 Petrópolis, Brazil.
authors.forename: Daiane C F
authors.initials: DC
authors.lastname: Golbert
authors.forename: Leandra
authors.initials: L
authors.lastname: Linhares-Lacerda
authors.forename: Luiz G
authors.initials: LG
authors.lastname: Almeida
authors.forename: Eliane
authors.initials: E
authors.lastname: Correa-de-Santana
authors.forename: Alice R
authors.initials: AR
authors.lastname: de Oliveira
authors.forename: Alex S
authors.initials: AS
authors.lastname: Mundstein
authors.forename: Wilson
authors.initials: W
authors.lastname: Savino
authors.forename: Ana T R
authors.initials: AT
authors.lastname: de Vasconcelos
mesh_terms: D000818:Animals; D030562:Databases, Protein; D015870:Gene Expression; D006801:Humans; D007797:Laminin / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D039781:PubMed; D051381:Rats; D014018:Tissue Distribution
chemical_list: D007797:Laminin