title: Changing epidemiology and clinical issues arising in an ageing cystic fibrosis population.
abstract: Improvements in the quality and implementation of medical care for individuals with cystic fibrosis (CF) have resulted in a dramatic improvement in survival. Many of these strategies have focused on the effective management of pulmonary disease which has delayed its manifestations into later years. With an increasing number of patients surviving to later years the impact of chronic inflammation and nutritional compromise on other organ systems over a lifetime are increasingly manifest. This review highlights the changing epidemiology of the ageing CF population and the complications that may ensue.
authors.affiliation: Department of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Parkins
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Parkins
authors.forename: Jackie C
authors.initials: JC
authors.lastname: Rendall
authors.forename: Stuart
authors.initials: S
authors.lastname: Elborn
mesh_terms: D000375:Aging; D003550:Cystic Fibrosis / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology; D010024:Osteoporosis / Q000453:epidemiology; D010195:Pancreatitis / Q000453:epidemiology; D011014:Pneumonia / Q000453:epidemiology*; D014550:Urinary Incontinence, Stress / Q000453:epidemiology