title: Enantioselective organocatalytic domino Michael-acetalization-Henry reactions of 2-hydroxynitrostyrene and aldehyde for the synthesis of tetrahydro-6H-benzo[c]chromenones.
abstract: Asymmetric domino Michael-acetalization reactions of 2-hydroxynitrostyrene and aldehydes "on water" followed by oxidation providing the cis-3,4-disubstituted dihydrocoumarins with excellent enantioselectivities (up to >99% ee). The variant with glutaraldehyde underwent a highly stereoselective domino Michael-acetalization-Henry reaction to afford the tetrahydro-6H-benzo[c]chromen-6-ones after the subsequent oxidation.
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi, 621, Taiwan, ROC. chebch@ccu.edu.tw
authors.forename: Bor-Cherng
authors.initials: BC
authors.lastname: Hong
authors.forename: Prakash
authors.initials: P
authors.lastname: Kotame
authors.forename: Ju-Hsiou
authors.initials: JH
authors.lastname: Liao