title: Opposing contributions of polynucleotide phosphorylase and the membrane protein NlpI to biofilm formation by Salmonella enterica serovar Typhimurium.
abstract: CsgD and cyclic-3',5'-di-guanylate are key regulators of biofilm formation in Salmonella enterica serovar Typhimurium. Our results show that polynucleotide phosphorylase and NlpI oppositely altered expression of CsgD. Polynucleotide phosphorylase and NlpI also had opposite effects on the expression of yjcC, which codes for a cyclic-3',5'-di-guanylate phosphodiesterase affecting CsgD expression.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Syed Fazle
authors.initials: SF
authors.lastname: Rouf
authors.forename: Irfan
authors.initials: I
authors.lastname: Ahmad
authors.forename: Naeem
authors.initials: N
authors.lastname: Anwar
authors.forename: Suman Kumar
authors.initials: SK
authors.lastname: Vodnala
authors.forename: Abdul
authors.initials: A
authors.lastname: Kader
authors.forename: Ute
authors.initials: U
authors.lastname: Römling
authors.forename: Mikael
authors.initials: M
authors.lastname: Rhen
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000096:biosynthesis; D001426:Bacterial Proteins / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D008074:Lipoproteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D011117:Polyribonucleotide Nucleotidyltransferase / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000502:physiology*; D015534:Trans-Activators / Q000096:biosynthesis
chemical_list: D001426:Bacterial Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D015534:Trans-Activators; D011117:Polyribonucleotide Nucleotidyltransferase; D015106:3',5'-Cyclic-GMP Phosphodiesterases