title: The development of a new computational model for the electromechanics of the human ventricular myocyte.
abstract: In this work we present a new electromechanical cardiac myocyte model tailored to reproduce the electrical and force generating activities of human ventricular myocytes. The model was created by coupling two existing models: the ten Tusscher electrophysiology model and the Rice myofilament mechanics model. The parameters of the new model were adjusted in order to replicate the available experimental data for human myocytes. The main challenges in this work were the strong feedbacks between the models, the high non-linearity of the models and mainly the lack of human data to make the adjustments.
authors.affiliation: Program of Computational Modeling, Federal University of Juiz de Fora, Brazil. bernardo.lino.oliveira@gmail.com
authors.forename: Bernardo Lino
authors.initials: BL
authors.lastname: de Oliveira
authors.forename: Joakim
authors.initials: J
authors.lastname: Sundnes
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Weber Dos Santos
mesh_terms: D002118:Calcium / Q000378:metabolism; D003198:Computer Simulation; D006352:Heart Ventricles / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D015203:Reproducibility of Results
chemical_list: D002118:Calcium