title: FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model.
abstract: To clarify the effect of fibroblast growth factor-21 (FGF-21) on islet transplantation, a suboptimal number of islets were transplanted into streptozotocin (STZ)-induced diabetic mice with or without FGF-21 treatment. Three-day treatment with FGF-21 contributed to restoration of normoglycemia by suppressing islet graft loss. The FGF-21-treated mice showed lower glycemic levels despite similar insulin content in the graft than that in untreated mice on day 3, indicating that FGF-21 not only has a cytoprotective effect but also decreases β-cell load by increasing insulin sensitivity. These results suggest that FGF-21 may be useful as a treatment to improve islet engraftment rates in clinical islet transplantation.
authors.affiliation: Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
authors.forename: Taeko
authors.initials: T
authors.lastname: Uonaga
authors.forename: Kentaro
authors.initials: K
authors.lastname: Toyoda
authors.forename: Teru
authors.initials: T
authors.lastname: Okitsu
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Zhuang
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yamane
authors.forename: Shinji
authors.initials: S
authors.lastname: Uemoto
authors.forename: Nobuya
authors.initials: N
authors.lastname: Inagaki
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D005346:Fibroblast Growth Factors / Q000494:pharmacology* / Q000627:therapeutic use; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D013311:Streptozocin; D019172:Transplantation Conditioning / Q000379:methods; D014185:Transplantation, Isogeneic
chemical_list: D001786:Blood Glucose; D007328:Insulin; C414620:fibroblast growth factor 21; D013311:Streptozocin; D005346:Fibroblast Growth Factors