title: Reversible cobalt ion binding to imidazole-modified nanopipettes.
abstract: In this report, we demonstrate that quartz nanopipettes modified with an imidazole-terminated silane respond to metal ions (Co(2+)) in solution. The response of nanopipettes is evaluated through examination of the ion current rectification ratio. When nanopipettes are cycled between solutions of different pH, adsorbed Co(2+) can be released from the nanopipette surface, to regenerate binding sites of the nanopipette. These results demonstrate that rectification-based sensing strategies for nanopore sensors can benefit from selection of recognition elements with intermediate binding affinities, such that reversible responses can be attained.
authors.forename: Niya
authors.initials: N
authors.lastname: Sa
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Fu
authors.forename: Lane A
authors.initials: LA
authors.lastname: Baker
mesh_terms: D001665:Binding Sites; D002412:Cations; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D003035:Cobalt / Q000032:analysis / Q000302:isolation & purification*; D004867:Equipment Design; D004864:Equipment and Supplies; D007093:Imidazoles; D058608:Nanopores; D049329:Nanostructures; D012821:Silanes
chemical_list: D002412:Cations; D007093:Imidazoles; D012821:Silanes; D003035:Cobalt; C029899:imidazole