title: Effect of preoperative pupil size on quality of vision after wavefront-guided LASIK.
abstract: OBJECTIVE
  To evaluate the effect of preoperative pupil size on quality of vision after wavefront-guided LASIK.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  One hundred two eyes.
  
  
  METHODS
  LASIK for mild to moderate myopia or astigmatism (preoperative manifest spherical equivalent, -3.99±1.42 diopters).
  
  
  METHODS
  Questionnaires evaluating specific visual symptoms before and after surgery. Each eye was evaluated before surgery, and 1 week and 1, 3, 6, and 12 months postoperatively. Pupils were stratified according to size: small (≤5.5 mm), medium (5.6-6.4 mm), or large (≥6.5 mm). Mesopic pupil size and preoperative and postoperative variables were evaluated using an analysis of variance. A regression model was also performed to determine the correlation between mean spherical equivalent and cylinder and visual symptoms.
  
  
  RESULTS
  In the early postoperative period, there was no difference between the 3 groups with regard to any of the symptoms. At the final 12-month postoperative visit, patients with medium pupils experienced less glare at night than small pupils (P = 0.02), medium pupils had less halos than small or large pupils (P = 0.001 and P = 0.02, respectively), and medium pupils experienced greater satisfaction in visual improvement than small pupils (P = 0.014).
  
  
  CONCLUSIONS
  Twelve months after wavefront-guided LASIK surgery, large pupil size does not positively correlate with any postoperative visual symptoms.
authors.affiliation: Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Annie
authors.initials: A
authors.lastname: Chan
authors.forename: Edward E
authors.initials: EE
authors.lastname: Manche
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000601:surgery*; D005260:Female; D019466:Glare; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D011680:Pupil / Q000502:physiology*; D011795:Surveys and Questionnaires; D014792:Visual Acuity / Q000502:physiology*