title: Association of serum adiponectin levels with artherosclerosis and the metabolic syndrome in obese children.
abstract: BACKGROUND
  The atherosclerotic process starts at an early age and is linked to obesity. However, the exact pathophysiological mechanism is poorly understood.
  
  
  OBJECTIVE
  To investigate the relationship between serum adiponectin and metabolic syndrome and early arteriosclerosis.
  
  
  METHODS
  176 obese and 88 normal children.
  
  
  METHODS
  Ultrasound measurement was performed to investigate IMT, FMD, carotid artery compliance (CAC). Adiponectin was measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Adiponectin levels correlated negatively with obese markers, blood pressure, fasting insulin, high sensitive CRP, HOMA-IR and IMT; marginally positively associated with CAC and HDL-c. The risk of metabolic syndrome increased 3.43 times when adiponectin levels were less than 7060 ng/ml. Heavy obesity, hypertension, low HDL-c, fasting hyperinsulin, High LDL-c and metabolic syndrome percentage were different in three groups according to the cut-off value of adiponectin.
  
  
  CONCLUSIONS
  Low adiponectin levels are associated with a high incidence of metabolic syndrome.
authors.affiliation: Department of Health Care, Qian-Fo-Shan Hospital Affiliated to Shan-dong University, Jinan, 250014, PR China. liuyunling1965@163.com
authors.forename: Yun-Ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Hong-Ri
authors.initials: HR
authors.lastname: Liang
authors.forename: Hao-Tian
authors.initials: HT
authors.lastname: Liu
authors.forename: Shu-Ying
authors.initials: SY
authors.lastname: Li
authors.forename: Ye-ying
authors.initials: YY
authors.lastname: Zhou
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Cheng
authors.forename: Liao-Sheng
authors.initials: LS
authors.lastname: Zhou
mesh_terms: D050153:Abdominal Fat / Q000000981:diagnostic imaging / Q000473:pathology; D052242:Adiponectin / Q000097:blood; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D001916:Brachial Artery / Q000473:pathology / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D012372:ROC Curve; D012039:Regional Blood Flow; D012307:Risk Factors; D014463:Ultrasonography
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008074:Lipoproteins