title: Role of ZNRD1 (zinc ribbon domain-containing 1) in angiogenesis of leukaemia cells.
abstract: Here, we have first investigated the roles of ZNRD1 in angiogenesis of leukaemia. The leukaemia cell line K562 was transfected with the vector that included the full-length cDNA of ZNRD1, then the growth and angiogenesis of cells were detected. Up-regulation of ZNRD1 could significantly inhibit the growth of cells, reduce tumour microvessel densities and inhibit the VEGF (vascular endothelial growth factor) production. The results of human miRNA array and real-time PCR showed that ZNRD1 could significantly up-regulate the expression of miR-214 and down-regulate the expression of miR-296. Taken together, ZNRD1 might inhibit tumour angiogenesis and could be considered as a target for leukaemia therapy.
authors.affiliation: State Key Laboratory of Tumor Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xian 710032, Shaanxi Province, Peoples Republic of China. hlhyhj@126.com
authors.forename: Liu
authors.initials: L
authors.lastname: Hong
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.forename: Shujun
authors.initials: S
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Yang
authors.forename: Taiqian
authors.initials: T
authors.lastname: Gong
authors.forename: Jipeng
authors.initials: J
authors.lastname: Li
authors.forename: Jianyong
authors.initials: J
authors.lastname: Zheng
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
authors.forename: Kaichun
authors.initials: K
authors.lastname: Wu
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
mesh_terms: D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D035683:MicroRNAs; C406241:POLR1H protein, human