title: Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?
abstract: Endocytosis modulates the activities of members of a family of receptors known as Frizzled (Fz) proteins, which control canonical β-catenin signaling and the planar cell polarity pathway; however, what determines which of the two pathways is activated is unclear. Evidence now suggests that the guanosine triphosphatase Rab5, a key regulator of endocytosis, binds directly to Fz proteins and that subsequent trafficking steps determine the outcome of Fz signaling.
authors.affiliation: Medical Research Council (MRC) Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
authors.forename: David
authors.initials: D
authors.lastname: Strutt
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Vincent
mesh_terms: D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D004705:Endocytosis; D051157:Frizzled Receptors / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction; D051176:beta Catenin / Q000378:metabolism*; D020696:rab5 GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D051157:Frizzled Receptors; D043562:Receptors, G-Protein-Coupled; D051176:beta Catenin; C058784:fz protein, Drosophila; D019204:GTP-Binding Proteins; D020696:rab5 GTP-Binding Proteins