title: RNAs: regulators of bacterial virulence.
abstract: RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5' and 3' untranslated regions next to the coding sequence, cis-acting antisense RNAs and trans-acting small non-coding RNAs, are effective regulatory molecules that can influence protein expression and function in response to external cues such as temperature, pH and levels of metabolites. This Review discusses the mechanisms by which these regulatory RNAs, together with accessory proteins such as RNases, control the fate of mRNAs and proteins and how this regulation influences virulence in pathogenic bacteria.
authors.affiliation: Department of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, 90187 Umeå, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Gripenland
authors.forename: Sakura
authors.initials: S
authors.lastname: Netterling
authors.forename: Edmund
authors.initials: E
authors.lastname: Loh
authors.forename: Teresa
authors.initials: T
authors.lastname: Tiensuu
authors.forename: Alejandro
authors.initials: A
authors.lastname: Toledo-Arana
authors.forename: Jörgen
authors.initials: J
authors.lastname: Johansson
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000378:metabolism; D016372:RNA, Antisense / Q000378:metabolism; D012329:RNA, Bacterial / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D016372:RNA, Antisense; D012329:RNA, Bacterial; D012333:RNA, Messenger; D022661:RNA, Untranslated