title: Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma.
abstract: BACKGROUND
  Epidemiological studies have clearly validated the association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with chronic HBV infection are at increased risk of HCC, in particular those with active liver disease and cirrhosis.
  
  
  METHODS
  We catalogued all published interactions between HBV and human proteins, identifying 250 descriptions of HBV and human protein interactions and 146 unique human proteins that interact with HBV proteins by text mining.
  
  
  RESULTS
  Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HBV are made up of core proteins that are interconnected with many pathways. A global analysis based on functional annotation highlighted the enrichment of cellular pathways targeted by HBV.
  
  
  CONCLUSIONS
  By connecting the cellular proteins targeted by HBV, we have constructed a central network of proteins associated with hepatocellular carcinoma, which might be to regard as the basis of a detailed map for tracking new cellular interactions, and guiding future investigations.
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: De-Rong
authors.initials: DR
authors.lastname: Huang
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Wang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000821:virology*; D057225:Data Mining; D006515:Hepatitis B virus / Q000378:metabolism*; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000821:virology*; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins