title: Cationic nucleolipids as efficient siRNA carriers.
abstract: We synthesized five novel uridine-based cationic nucleolipids, introducing basic amino acid residues at the 5' position of uridine, through 1,3-dipolar cycloaddition, and hydrophobic alkyl moieties at the 2' and 3' positions, through carbamate linkages. Their lipoplexes delivered siRNAs efficiently to cells, in vitro, without any severe toxicity.
authors.affiliation: Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang, 790-784 Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Yang
authors.forename: Jeong Wu
authors.initials: JW
authors.lastname: Yi
authors.forename: Eun-Kyoung
authors.initials: EK
authors.lastname: Bang
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Jeon
authors.forename: Byeang Hyean
authors.initials: BH
authors.lastname: Kim
mesh_terms: D002412:Cations / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008055:Lipids / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D034741:RNA, Small Interfering / Q000737:chemistry*
chemical_list: D002412:Cations; D008055:Lipids; D034741:RNA, Small Interfering