title: First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents.
abstract: Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Lee
authors.forename: Chi-Huan
authors.initials: CH
authors.lastname: Huang
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Wang
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Chuang
authors.forename: Ming-Jung
authors.initials: MJ
authors.lastname: Wu
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Yeh-Long
authors.initials: YL
authors.lastname: Chen
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000494:pharmacology; D000840:Anisoles / Q000138:chemical synthesis* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000480:Alkynes; D000840:Anisoles; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; C550852:antrocamphin A