title: Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Chao Family Comprehensive Cancer Center, University of Irvine Medical Center, Orange, California 92868-3298, USA. Ignatius.ou@uci.edu
authors.forename: Sai-Hong Ignatius
authors.initials: SH
authors.lastname: Ou
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Bazhenova
authors.forename: D Ross
authors.initials: DR
authors.lastname: Camidge
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Solomon
authors.forename: June
authors.initials: J
authors.lastname: Herman
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kain
authors.forename: Yung-Jue
authors.initials: YJ
authors.lastname: Bang
authors.forename: Eunice L
authors.initials: EL
authors.lastname: Kwak
authors.forename: Alice T
authors.initials: AT
authors.lastname: Shaw
authors.forename: Ravi
authors.initials: R
authors.lastname: Salgia
authors.forename: Robert G
authors.initials: RG
authors.lastname: Maki
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Clark
authors.forename: Keith D
authors.initials: KD
authors.lastname: Wilner
authors.forename: A John
authors.initials: AJ
authors.lastname: Iafrate
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics; D000077547:Crizotinib; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics; D049268:Positron-Emission Tomography; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras); D011720:Pyrazoles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D020794:Receptor Protein-Tyrosine Kinases; D017978:Receptors, Growth Factor / Q000235:genetics; D014057:Tomography, X-Ray Computed; D018631:ras Proteins / Q000235:genetics
chemical_list: C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D011720:Pyrazoles; D011725:Pyridines; D017978:Receptors, Growth Factor; D000077547:Crizotinib; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; C491743:MET protein, human; D011505:Protein-Tyrosine Kinases; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins