title: Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified.
abstract: To elucidate the expression of tumor-associated macrophages (TAMs) and vascular endothelial growth factor (VEGF) in peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and their correlation with patient clinical characteristics and overall survival (OS), immunohistochemistry stains for CD68 and VEGF were applied to 38 tissue specimens of PTCL-NOS. The CD68+ cell content and VEGF-positive rates were significantly higher in PTCL-NOS tissues (p < 0.05). TAMs were significantly related to bone marrow invasion, international prognostic index (IPI) score, and response to treatment (p < 0.05). The 2-year OS of the high-TAMs-expression group (>50/hpf) was 22.2%, and that of the low-TAMs-expression group (<50/hpf) was 52.8% (p < 0.05). The expression of VEGF was closely related to tumor staging, bone marrow invasion, and IPI score (p < 0.05). The 2-year OS of the VEGF-positive group was 25.4%, and that of the VEGF-negative group was 83.3% (p < 0.01). Therefore, TAMs and VEGF, which were significantly correlated to prognosis of the disease, may be involved in the tumorigenesis, progression, invasion, and angiogenesis of PTCL-NOS.
authors.affiliation: Department of Hematology, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Daobin
authors.initials: D
authors.lastname: Zhou
authors.forename: Quancai
authors.initials: Q
authors.lastname: Cui
authors.forename: Dachun
authors.initials: D
authors.lastname: Zhao
authors.forename: Yongji
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D016411:Lymphoma, T-Cell, Peripheral / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D055815:Young Adult; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D042461:Vascular Endothelial Growth Factor A; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C467484:VEGFA protein, human