title: Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia.
abstract: Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.
authors.affiliation: Clinical Molecular Biology Laboratory, Dept. of Laboratory Medicine, PTV, Rome, Italy. paolo.gravina@ptvonline.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Gravina
authors.forename: Ilaria
authors.initials: I
authors.lastname: Spoletini
authors.forename: Silvia
authors.initials: S
authors.lastname: Masini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Valentini
authors.forename: Diego
authors.initials: D
authors.lastname: Vanni
authors.forename: Eleonora
authors.initials: E
authors.lastname: Paladini
authors.forename: Paola
authors.initials: P
authors.lastname: Bossù
authors.forename: Carlo
authors.initials: C
authors.lastname: Caltagirone
authors.forename: Giorgio
authors.initials: G
authors.lastname: Federici
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Spalletta
authors.forename: Sergio
authors.initials: S
authors.lastname: Bernardini
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics*
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C484555:GSTA1 protein, human