title: Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse.
abstract: Oxidative stress is considered a major contributor in the pathology of multiple sclerosis (MS). Acrolein, a highly reactive aldehyde byproduct of lipid peroxidation, is thought to perpetuate oxidative stress. In this study, we aimed to determine the role of acrolein in an animal model of MS, experimental autoimmune encephalomyelitis (EAE) mice. We have demonstrated a significant elevation of acrolein protein adduct levels in EAE mouse spinal cord. Hydralazine, a known acrolein scavenger, significantly improved behavioral outcomes and lessened myelin damage in spinal cord. We postulate that acrolein is an important pathological factor and likely a novel therapeutic target in MS.
authors.affiliation: Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: G
authors.initials: G
authors.lastname: Leung
authors.forename: W
authors.initials: W
authors.lastname: Sun
authors.forename: L
authors.initials: L
authors.lastname: Zheng
authors.forename: S
authors.initials: S
authors.lastname: Brookes
authors.forename: M
authors.initials: M
authors.lastname: Tully
authors.forename: R
authors.initials: R
authors.lastname: Shi
mesh_terms: D000171:Acrolein / Q000037:antagonists & inhibitors*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006830:Hydralazine / Q000494:pharmacology; D015151:Immunoblotting; D051379:Mice; D008810:Mice, Inbred C57BL; D009186:Myelin Sheath / Q000187:drug effects / Q000473:pathology*; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology
chemical_list: D000975:Antioxidants; D006830:Hydralazine; D000171:Acrolein