title: Circulating biomarkers in neuroendocrine tumors of the enteropancreatic tract: application to diagnosis, monitoring disease, and as prognostic indicators.
abstract: Neuroendocrine tumors (NETs) are difficult to diagnose. Their symptoms may be vague or intermittent, and are frequently associated with much more common diseases; many of the tumors may be asymptomatic. Therefore, diagnosis can be delayed for some years. Because most NETs are secretory, the measurement of circulating biomarkers is helpful not only for diagnosis but also for assessing tumor response to treatment, monitoring disease progression, and use as prognostic indicators.
authors.affiliation: Regional Regulatory Peptide Laboratory, Kelvin Building, Royal Victoria Hospital, Grosvenor Road, Belfast, BT 126BA, UK.
authors.forename: Joy E S
authors.initials: JE
authors.lastname: Ardill
authors.forename: Thomas M
authors.initials: TM
authors.lastname: O'Dorisio
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D003938:Diagnostic Techniques, Digestive System; D003940:Diagnostic Techniques, Endocrine; D005770:Gastrointestinal Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D041981:Gastrointestinal Tract / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods; D018358:Neuroendocrine Tumors / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis
chemical_list: D015415:Biomarkers