title: Functional cationic nanomagnet-porphyrin hybrids for the photoinactivation of microorganisms.
abstract: Cationic nanomagnet-porphyrin hybrids were synthesized and their photodynamic therapy capabilities were investigated against the Gram (-) Escherichia coli bacteria, the Gram (+) Enterococcus faecalis bacteria and T4-like phage. The synthesis, structural characterization, photophysical properties, and antimicrobial activity of these new materials are discussed. The results show that these new multicharged nanomagnet-porphyrin hybrids are very stable in water and highly effective in the photoinactivation of bacteria and phages. Their remarkable antimicrobial activity, associated with their easy recovery, just by applying a magnetic field, makes these materials novel photosensitizers for water or wastewater disinfection.
authors.affiliation: QOPNA/Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
authors.forename: Carla M B
authors.initials: CM
authors.lastname: Carvalho
authors.forename: Eliana
authors.initials: E
authors.lastname: Alves
authors.forename: Liliana
authors.initials: L
authors.lastname: Costa
authors.forename: João P C
authors.initials: JP
authors.lastname: Tomé
authors.forename: Maria A F
authors.initials: MA
authors.lastname: Faustino
authors.forename: Maria G P M S
authors.initials: MG
authors.lastname: Neves
authors.forename: Augusto C
authors.initials: AC
authors.lastname: Tomé
authors.forename: José A S
authors.initials: JA
authors.lastname: Cavaleiro
authors.forename: Adelaide
authors.initials: A
authors.lastname: Almeida
authors.forename: Angela
authors.initials: A
authors.lastname: Cunha
authors.forename: Zhi
authors.initials: Z
authors.lastname: Lin
authors.forename: João
authors.initials: J
authors.lastname: Rocha
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D017122:Bacteriophage T4 / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013293:Enterococcus faecalis / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D008027:Light; D008280:Magnetics; D050296:Microbial Viability / Q000187:drug effects* / Q000528:radiation effects*; D049329:Nanostructures / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D011166:Porphyrins