title: Human tissue distribution of voriconazole.
abstract: Voriconazole concentrations were determined in autopsy samples of eight patients who had been treated for a median of 7 days (interquartile range [IQR], 5 days). Voriconazole penetrates well into various tissues, with median levels of 6.26 μg/g ((interquartile range [IQR], 7.87 μg/g) in the lung, 3.41 μg/g (IQR, 16.72 μg/g) in the brain, 6.89 μg/g (IQR, 24.16 μg/g) in the liver, 6.47 μg/g (IQR, 6.19 μg/g) in the kidneys, 5.60 μg/g (IQR, 11.49 μg/g) in the spleen, and 7.55 μg/g (IQR, 16.91 μg/g) in the myocardium.
authors.affiliation: Clinical Pharmacokinetics Unit, Inflammation Research Laboratory, Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Weiler
authors.forename: David
authors.initials: D
authors.lastname: Fiegl
authors.forename: Róisín
authors.initials: R
authors.lastname: MacFarland
authors.forename: Eva
authors.initials: E
authors.lastname: Stienecke
authors.forename: Rosa
authors.initials: R
authors.lastname: Bellmann-Weiler
authors.forename: Stefan
authors.initials: S
authors.lastname: Dunzendorfer
authors.forename: Michael
authors.initials: M
authors.lastname: Joannidis
authors.forename: Romuald
authors.initials: R
authors.lastname: Bellmann
mesh_terms: D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology; D001344:Autopsy; D001921:Brain / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013154:Spleen / Q000378:metabolism*; D014018:Tissue Distribution; D014230:Triazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D065819:Voriconazole; D055815:Young Adult
chemical_list: D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole