title: Population pharmacokinetic analysis of the active product of dipyrone.
abstract: OBJECTIVE
  Pharmacokinetics of 4-methyl-amino-antipyrine (MAA), the active metabolite of the nonsteroidal anti-inflammatory agent dipyrone, whose time course correlates to the therapeutic effect of the drug, are studied.
  
  
  METHODS
  153 patients hospitalized in the Department of Medicine at the Hadassah University Hospital, Jerusalem, Israel.
  
  
  METHODS
  Patients receiving dipyrone for the treatment of fever or pain were asked to participate in the study. Pharmacokinetics and statistical analysis: Using the population approach based on a formerly developed experimental model, the relationships between pharmacokinetic parameters and demographic and physiological covariates are explored.
  
  
  RESULTS
  The results of the analysis show considerable variability in pharmacokinetics across the study population, and a significant decrease in clearance with age.
  
  
  CONCLUSIONS
  A population pharmacokinetic analysis of MAA, the active product of dipyrone, reveals that age is a significant predictor of MAA disposition. Covariates that measure hepatic and renal function do not appear to be good predictors of the rate of MAA disposition.
authors.affiliation: Division of Clinical Pharmacology, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Levy
authors.forename: M
authors.initials: M
authors.lastname: Muszkat
authors.forename: B
authors.initials: B
authors.lastname: Rich
authors.forename: B
authors.initials: B
authors.lastname: Rosenkranz
authors.forename: P
authors.initials: P
authors.lastname: Schlattmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001499:Bayes Theorem; D004177:Dipyrone / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone