title: [Effect of tropoxin on cerebrovascular effects of meta-chlorophenylpiperazine and serotonin].
abstract: Experiments on rats showed that meta-chlorophenylpiperazine, as well as serotonin, decreases cerebral blood flow registered in internal carotid artery of narcotized animals. Therefore, this agonist of postsynaptic 5HT(2B/2C) receptors can be used for directed search of new antimigraine drugs. Tropoxin (10 mg/kg) substantially reduces constrictor reactions of cerebral blood vessels induced by meta-chlorophenylpiperazine. The effect was observed during both prophylaxis and treatment of the model disorder with this drug.
authors.forename: A A
authors.initials: AA
authors.lastname: Gorbunov
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
mesh_terms: D000818:Animals; D001372:Aza Compounds / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002343:Carotid Artery, Internal / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D044403:Receptor, Serotonin, 5-HT2B / Q000378:metabolism; D044405:Receptor, Serotonin, 5-HT2C / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology*; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: C114333:3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane; D001372:Aza Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010879:Piperazines; D044403:Receptor, Serotonin, 5-HT2B; D044405:Receptor, Serotonin, 5-HT2C; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D012701:Serotonin; C015068:1-(3-chlorophenyl)piperazine