title: Differential stimulation of ON and OFF retinal ganglion cells: a modeling study.
abstract: A model of the electrophysiological properties of ON and OFF retinal ganglion cells (RGCs) was constrained and validated using experimental data from the literature. Our simulations support experimental findings that differences in the magnitude of the T-type Ca(2+) current explain differences in the intrinsic electrophysiology of ON and OFF RGCs. The models are used to investigate the potential for differential stimulation of ON and OFF RGCs during neuroprosthetic stimulation with sinusoidal current. The model predicts that OFF cells fire preferential over ON cells in a frequency band around 10 Hz.
authors.affiliation: Department of Electrical Engineering, The University of Melbourn, Australia. tkam@unime.edu.au
authors.forename: Tatiana
authors.initials: T
authors.lastname: Kameneva
authors.forename: Hamish
authors.initials: H
authors.lastname: Meffin
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Burkitt
mesh_terms: D000818:Animals; D020747:Calcium Channels, T-Type / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D018408:Patch-Clamp Techniques; D012165:Retinal Ganglion Cells / Q000502:physiology*
chemical_list: D020747:Calcium Channels, T-Type