title: Cystic parathyroid adenoma: sonographic features and correlation with 99mTc-sestamibi SPECT findings.
abstract: OBJECTIVE
  The purpose of this study was to describe the typical ultrasound features of cystic parathyroid adenoma.
  
  
  METHODS
  A review of a surgical database and electronic medical records from 2006 to 2009 identified the cases of 15 patients who underwent preoperative cervical sonography for primary hyperparathyroidism with subsequent resection of pathologically proven parathyroid adenoma with predominantly cystic components. Two radiologists retrospectively evaluated the preoperative ultrasound images and assessed for cyst complexity, size, location, and color Doppler vascularity. Technetium-99m-sestamibi SPECT findings, surgical and pathologic reports, and the results of parathyroid hormone assay of the cyst fluid also were reviewed.
  
  
  RESULTS
  Most of the cystic adenomas (14/15, 93%) were deep or inferolateral to the adjacent thyroid. The same percentage were elongated and had peripheral nodular components. An echogenic border separating the adenoma from the overlying thyroid was identified in 9 of 15 patients (60%). Color Doppler examination of 14 patients showed feeding vessels with internal color flow to the solid components in 10 patients (71%). Six of 14 patients underwent preoperative or intraoperative sampling of cyst fluid, and the assay showed the parathyroid hormone levels ranged from 1,198 to greater than 5,000 pg/mL. Fourteen of 15 patients underwent preoperative sestamibi SPECT, and the adenoma was definitively localized in four patients (29%). The accuracy of preoperative localization improved to 79% (11/14) when sestamibi SPECT scans were interpreted in correlation with cervical ultrasound images.
  
  
  CONCLUSIONS
  Awareness of typical sonographic features (location, color Doppler vascularity) may aid radiologists in preoperative localization of parathyroid adenomas, even when cystic degeneration occurs. In cases in which imaging or clinical features are equivocal, the results of cyst fluid sampling and parathyroid hormone assay are confirmatory.
authors.affiliation: Department of Radiology, Division of Abdominal Imaging, University of Pittsburgh School of Medicine, 200 Lothrop St., Presbyterian South Tower, Ste. 3950, Pittsburgh, PA 15213, USA. johnsonna2@upmc.edu
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Johnson
authors.forename: Linwah
authors.initials: L
authors.lastname: Yip
authors.forename: Mitchell E
authors.initials: ME
authors.lastname: Tublin
mesh_terms: D000236:Adenoma / Q000150:complications / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D018615:Ultrasonography, Doppler, Color
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi