title: [The newborn infant of a mother with tuberculosis].
abstract: TBC is a major infectious emergency in the world. OMS suggest that there are 8 millions of affected every year and 2 millions of deaths. Italy is considered a country with low prevalence, but the increase of the immigration from Africa Asia and Est Europa (country with high risk) imposes attention to the problem. The delivery is a critical moment to investigate people at risk of disease. The infection of the newborn can happen intrauterine or in the expulsive period, but is possible also at home, from somebody affected by an active pulmonary disease. Diagnosis in the newborn is not easy for the aspecificity of clinical signs and for the frequent initial negativeness of Mantoux test. Culture of placenta, gastric aspirate, tracheal secretions, urine would be requested, cerebrospinal fluid if necessary. Neonatal disease needs therapy with isoniazide, rifampicine, pirazinamide and, or ethambutol, or streptomycin. Profilaxis of a newborn from a woman affected by an active form of tuberculosis or living with people affected by an active pulmonary form consists in giving isoniazide until diagnostic tests are negative and in removing the sicks (only with pulmonary disease). New dangerous kinds of pharmacological multiresistent tuberculosis are appeared in the last years in the world and, with the coinfection HIV-TBC and the reorganization of the surveillance system, represents the major obligation for the next years.
authors.affiliation: UOC TIN e Patologia Neonatale, Dipartimento di Pediatria, Policlinico Umberto I, Roma.
authors.forename: R
authors.initials: R
authors.lastname: Pedicino
authors.forename: K
authors.initials: K
authors.lastname: Bressan
authors.forename: M
authors.initials: M
authors.lastname: Bedetta
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001826:Body Fluids / Q000382:microbiology; D036861:Delivery, Obstetric; D054242:Emigrants and Immigrants; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology; D014943:Global Health; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007558:Italy / Q000453:epidemiology; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology*; D014376:Tuberculosis / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*
chemical_list: D000995:Antitubercular Agents