title: Effect of central compartment neck dissection on hypocalcaemia incidence after total thyroidectomy for carcinoma.
abstract: BACKGROUND
  Central compartment neck dissection is increasingly performed as part of surgical management of differentiated thyroid carcinoma. However, elective central neck dissection remains controversial due to complications and lack of evidence of survival benefit.
  
  
  OBJECTIVE
  To investigate and compare rates of transient and permanent hypocalcaemia following total thyroidectomy alone, compared with total thyroidectomy with central neck dissection, for differentiated thyroid carcinoma.
  
  
  METHODS
  Retrospective study of 127 consecutive patients referred with differentiated thyroid carcinoma, 2004-2006; 78 patients had undergone total thyroidectomy (group one) and 49 total thyroidectomy with central compartment node dissection (group two). Surgery was performed in various hospitals by both otolaryngologists and endocrine surgeons.
  
  
  RESULTS
  In groups one and two, the incidence of transient hypocalcaemia was 18 per cent (14/78) and 51 per cent (25/49) (p < 0.001), and the incidence of permanent hypocalcaemia 1 per cent (one of 77) and 12 per cent (six of 49) (p < 0.01), respectively. Most patients undergoing central neck dissection had evidence of pathological level six lymphadenopathy (29/49).
  
  
  CONCLUSIONS
  Total thyroidectomy combined with central neck dissection for the treatment of differentiated thyroid carcinoma is more likely to result in transient (51 per cent) and permanent (12 per cent) hypocalcaemia. Elective neck dissection should be performed selectively, with a high expectation of post-operative hypocalcaemia.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, Manchester, UK.
authors.forename: I
authors.initials: I
authors.lastname: Mitra
authors.forename: J R
authors.initials: JR
authors.lastname: Nichani
authors.forename: B
authors.initials: B
authors.lastname: Yap
authors.forename: J J
authors.initials: JJ
authors.lastname: Homer
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D015994:Incidence; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000009:adverse effects*; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom