title: Regulation of bone mass by serotonin: molecular biology and therapeutic implications.
abstract: The molecular elucidation of two human skeletal dysplasias revealed that they are caused by an increase or a decrease in the synthesis of serotonin by enterochromaffin cells of the gut. This observation revealed a novel and powerful endocrine means to regulate bone mass. Exploiting these findings in the pharmacological arena led to the demonstration that inhibiting synthesis of gut-derived serotonin could be an effective means to treat low-bone-mass diseases such as osteoporosis.
authors.affiliation: Department of Genetics & Development, Columbia University Medical Center, New York, New York 10032, USA. jpb2@columbia.edu
authors.forename: Gerard
authors.initials: G
authors.lastname: Karsenty
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Yadav
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004386:Duodenum / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D051379:Mice; D010013:Osteogenesis Imperfecta / Q000235:genetics; D010024:Osteoporosis / Q000188:drug therapy* / Q000235:genetics; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D014365:Tryptophan Hydroxylase / Q000037:antagonists & inhibitors*
chemical_list: D026502:LDL-Receptor Related Proteins; C548240:LP533401; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; C555483:Lrp5 protein, mouse; D011743:Pyrimidines; D012702:Serotonin Antagonists; D012701:Serotonin; C497467:TPH1 protein, human; D014365:Tryptophan Hydroxylase