title: Metalloproteomics and metal toxicology of α-synuclein.
abstract: Significant evidence has been accumulated linking exposure to heavy metals and/or distortion of metal homeostasis with the development of various neurodegenerative diseases. α-Synuclein is known to be involved in pathogenesis of a subset of neurodegenerative diseases collectively known as synucleinopathies. Therefore the interplay between metals, α-synuclein and neurodegeneration has attracted significant attention of researchers. This review discusses some of the aspects of the α-synuclein metalloproteomics and represents the peculiarities and consequences of α-synuclein interaction with various metal ions. Both non-specific and specific binding of this protein to metals is considered together with the analysis of the effects of such interactions on α-synuclein structure and aggregation propensity.
authors.affiliation: Molecular Kinetics Inc., 6201 La Pas Trail, Indianapolis, IN 46268, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Santner
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Uversky
mesh_terms: D000535:Aluminum / Q000737:chemistry / Q000633:toxicity*; D003300:Copper / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D007477:Ions; D008968:Molecular Conformation; D040901:Proteomics; D051844:alpha-Synuclein / Q000737:chemistry
chemical_list: D007477:Ions; D051844:alpha-Synuclein; D003300:Copper; D000535:Aluminum