title: The bioactivity and ion release of titanium-containing glass polyalkenoate cements for medical applications.
abstract: The ion release profiles and bioactivity of a series of Ti containing glass polyalkenoate cements. Characterization revealed each material to be amorphous with a T(g) in the region of 650-660°C. The network connectivity decreased (1.83-1.35) with the addition of TiO(2) which was also evident with analysis by X-ray photoelectron spectroscopy. Ion release from cements were determined using atomic absorption spectroscopy for zinc (Zn(2+)), calcium (Ca(2+)), strontium (Sr(2+)), Silica (Si(4+)) and titanium (Ti(4+)). Ions such as Zn(2+) (0.1-2.0 mg/l), Ca(2+) (2.0-8.3 mg/l,) Sr(2+) (0.1-3.9 mg/l), and Si(4+) (14-90 mg/l) were tested over 1-30 days. No Ti(4+) release was detected. Simulated body fluid revealed a CaP surface layer on each cement while cell culture testing of cement liquid extracts with TW-Z (5 mol% TiO(2)) produced the highest cell viability (161%) after 30 days. Direct contact testing of discs resulted in a decrease in cell viability of the each cement tested.
authors.affiliation: Inamori School of Engineering, Alfred University, Alfred, NY 14802, USA. wren@alfred.edu
authors.forename: A W
authors.initials: AW
authors.lastname: Wren
authors.forename: N M
authors.initials: NM
authors.lastname: Cummins
authors.forename: F R
authors.initials: FR
authors.lastname: Laffir
authors.forename: S P
authors.initials: SP
authors.lastname: Hudson
authors.forename: M R
authors.initials: MR
authors.lastname: Towler
mesh_terms: D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001697:Biomedical and Dental Materials / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D001826:Body Fluids / Q000502:physiology; D002478:Cells, Cultured; D004055:Differential Thermal Analysis; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D005899:Glass Ionomer Cements / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007477:Ions / Q000032:analysis / Q000493:pharmacokinetics*; D008422:Materials Testing; D056951:Photoelectron Spectroscopy; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001697:Biomedical and Dental Materials; D005899:Glass Ionomer Cements; D007477:Ions; D014025:Titanium