title: An ex(o)citing machinery for invasive tumor growth.
abstract: Cancer cells communicate with the environment through delivery of surface proteins, release of soluble factors (growth factors and cytokines), and sophisticated nanovehicles (exosomes) for establishment of invasive tumor growth. This communication occurs in part through constitutive exocytosis, regulated exocytosis, or release of intraluminal vesicles, and is modulated by small Rab GTPases, the master regulators of vesicle traffic. We studied Rab GTPases implicated in regulated exocytosis and showed a unique role for Rab27B in invasive tumor growth. Emerging evidence indicates that various exocytic routes are implemented by cancer cells to relay crucial information for fostering growth, migration, and matrix degradation.
authors.affiliation: Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.
authors.forename: An
authors.initials: A
authors.lastname: Hendrix
authors.forename: Wendy
authors.initials: W
authors.lastname: Westbroek
authors.forename: Marc
authors.initials: M
authors.lastname: Bracke
authors.forename: Olivier
authors.initials: O
authors.lastname: De Wever
mesh_terms: D045744:Cell Line, Tumor; D005089:Exocytosis; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D022142:Secretory Vesicles / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000378:metabolism
chemical_list: C512960:Rab27B protein, human; D020691:rab GTP-Binding Proteins