title: The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases.
abstract: Few therapeutic alternatives remain for the treatment of infections due to multiresistant Mycobacterium abscessus. Here we show that the peptidoglycans of the "rough" and "smooth" morphotypes contain predominantly 3→3 cross-links generated by l,d-transpeptidases, indicating that these enzymes are attractive targets for the development of efficient drugs.
authors.affiliation: LRMA, Equipe 12, Centre de Recherches des Cordeliers, 15 rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. jean-luc.mainardi@crc.jussieu.fr
authors.forename: Marie
authors.initials: M
authors.lastname: Lavollay
authors.forename: Martine
authors.initials: M
authors.lastname: Fourgeaud
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Herrmann
authors.forename: Lionel
authors.initials: L
authors.lastname: Dubost
authors.forename: Arul
authors.initials: A
authors.lastname: Marie
authors.forename: Laurent
authors.initials: L
authors.lastname: Gutmann
authors.forename: Michel
authors.initials: M
authors.lastname: Arthur
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Mainardi
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D002473:Cell Wall / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D009161:Mycobacterium / Q000737:chemistry / Q000201:enzymology* / Q000378:metabolism*; D010457:Peptidoglycan / Q000737:chemistry / Q000378:metabolism*; D010458:Peptidyl Transferases / Q000378:metabolism*; D053719:Tandem Mass Spectrometry
chemical_list: D001426:Bacterial Proteins; D010457:Peptidoglycan; D010458:Peptidyl Transferases