title: Use of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (P-15) in the treatment isolated Class I gingival recession of defects: a pilot study.
abstract: BACKGROUND
  This study clinically evaluates the treatment outcome of coronally positioned flap (CPF) associated with anorganic bone mineral/peptide-15 (ABM/P-15) in terms of root coverage and gain in clinical attachment level (CAL) and bone height (BH) in isolated Class I gingival recession (GR) defects.
  
  
  METHODS
  Fifteen healthy subjects with bilateral and comparable Miller Class I GR defects were selected. The defects were randomly assigned either to the test group (CPF with ABM/P-15) or to the control group (CPF only).
  
  
  RESULTS
  Six months after surgery, a reduction in GR was observed in the test and control groups (2.20 ± 0.54 and 2.40 ± 0.80 mm, respectively; P <0.001) with no intergroup difference (P = 0.33). Complete root coverage was obtained in 10 and 11 defects in the test and control groups, respectively. In the test group 85.56% ± 21.69% and in the control group 90.00% ± 18.42% of the exposed root was covered. Although not clinically significant, a statistically greater increase in the gingival thickness was observed in the test group (0.03 mm; P = 0.01). CAL gain was significant in both groups (test group, 1.93 ± 0.44 mm; control group, 2.13 ± 1.15 mm; P <0.001) with no intergroup difference (P = 0.42). Intergroup and intragroup differences in width of keratinized tissue and BH were not significant (P ≥0.16). In the test group, a positive correlation was observed between BH at baseline and the reduction in GR (r = 0.56; P = 0.03).
  
  
  CONCLUSIONS
  In isolated Class I GR defects, CPF associated with ABM/P-15 provided no significant difference in root coverage and CAL gain compared to CPF alone. In the ABM/P-15 group, a greater reduction in GR was associated with higher bone level at baseline.
authors.affiliation: Department of Periodontics, School of Dentistry, Federal University of Bahia, Bahia, Brazil.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Nazareth
authors.forename: Patricia R
authors.initials: PR
authors.lastname: Cury
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery; D000539:Alveolar Process / Q000473:pathology; D018786:Bone Substitutes / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D003774:Dental Plaque Index; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology; D005884:Gingival Hemorrhage / Q000145:classification; D005889:Gingival Recession / Q000145:classification / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D010865:Pilot Projects; D016745:Root Planing; D013524:Surgical Flaps; D014092:Tooth Root / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen; D017886:Durapatite