title: Integrated fluidic system for bio-molecule separation.
abstract: An integrated fluidic system has been fabricated, capable of separating a mixture of different bio-molecules into its components. It is composed of a filter and an actuator; the pressure generated by the actuator sustains the flow of the mixture through the filter. The actuator is made by stacking several layers of conductive polymer. Actuator strain in excess of 10% has been obtained, which corresponds to a fluid flow of 3 microL/min in the fabricated system. The filter consists of an ordered array of Si micro-pillars. A mixture composed of DNA fragments of different length (300 and 400 base-pair) has been effectively separated by using the fabricated filter and chromatographic techniques.
authors.affiliation: Imec, Kapeldreef 75, 3001 Leuven, Belgium. hiraoka.maki@jp.panasonic.com
authors.forename: M
authors.initials: M
authors.lastname: Hiraoka
authors.forename: P
authors.initials: P
authors.lastname: Fiorini
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: De Malsche
authors.forename: B
authors.initials: B
authors.lastname: Majeed
authors.forename: D
authors.initials: D
authors.lastname: Sabuncuoglu Tezcan
authors.forename: G
authors.initials: G
authors.lastname: Desmet
authors.forename: I
authors.initials: I
authors.lastname: Yamashita
authors.forename: C
authors.initials: C
authors.lastname: Van Hoof
authors.forename: M
authors.initials: M
authors.lastname: Op de Beeck
mesh_terms: D002845:Chromatography / Q000379:methods; D004247:DNA / Q000302:isolation & purification; D004867:Equipment Design; D005374:Filtration / Q000379:methods; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation* / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry
chemical_list: D011108:Polymers; D004247:DNA