title: [A study on apoptosis induced by As₂O₃ for small cell lung cancer].
abstract: BACKGROUND
  To study apoptosis of small cell lung cancer (SCLC) cell induced by As₂O₃ and enhancement effect of interferon (IFN) on As₂O₃.
  
  
  METHODS
  DNA gel electrophoresis, terminal deoxynucleotidyl transferase nick end labeling (TUNEL) and immunocytochemistry were used to detect the apoptosis induced by As₂O₃ with different doses and time and the expression of Bcl-2 or PCNA.
  
  
  RESULTS
  Within certain extent of concentration, As₂O₃ could induce apoptosis of SCLC cells. And apoptotic cells increased and expression of Bcl 2 and PCNA decreased with time prolonged or dose increased. The apoptosis inducing effect of As₂O₃ combined with IFN was much higher than that of As₂O₃ alone.
  
  
  CONCLUSIONS
  As₂O₃ may induce apoptosis of SCLC cells and the efficiency of apoptosis is related to dose and time. IFNα-2b might enhance the effect of apoptosis on SCLC induced by As₂O₃.
authors.affiliation: Radiobiology Department , Fujian Tumor Hospital , Fuzhou , Fujian 350014, P . R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Su
authors.forename: S
authors.initials: S
authors.lastname: Shen
authors.forename: P
authors.initials: P
authors.lastname: Gao
authors.forename: C
authors.initials: C
authors.lastname: Zou
authors.forename: Z
authors.initials: Z
authors.lastname: Chen