title: Use of drugs known to cause fetal harm among women delivering infants in Haiti.
abstract: OBJECTIVE
  To estimate the prevalence of use of fetal-harm drugs among women who received postpartum care in hospitals in Haiti and to identify groups of women at higher risk for potentially harmful medication exposures.
  
  
  METHODS
  Women who received postpartum care in 2 large hospitals in Port-au-Prince, Haiti, from August 18 to December 1, 2008, were surveyed in Creole about their use of medications in pregnancy, including fetal-harm drugs.
  
  
  RESULTS
  We surveyed 482 women who had a median age of 26 years. Approximately 75% reported using at least 1 medicine in pregnancy, with the most common being amoxicillin (n = 127), acetaminophen (n = 109), metronidazole (n = 79), and misoprostol (n = 38). More than 13% used fetal-harm drugs, including misoprostol and tetracycline. Unmarried women (adjusted relative risk [RR] 2.2; 95% confidence interval [CI], 1.0-4.7) and separated women (adjusted RR 4.6; CI, 1.8-11.9) were more likely than married women to report use of fetal-harm drugs. In addition, women with 4 or more children were more likely to report use of medications known to cause fetal harm (adjusted RR 4.3; CI, 1.9-9.9).
  
  
  CONCLUSIONS
  Women who delivered infants in Haiti commonly report use of fetal-harm drugs. The public health implications of these findings are broad and relate to complex issues such as pregnancy planning and regulation of medications to prevent potentially harmful exposures.
authors.affiliation: Master of Public Health Program, Vanderbilt University School of Medicine, Nashville, Tenn 37232-4313, USA.
authors.forename: Astride
authors.initials: A
authors.lastname: Jules
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Kaltenbach
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Arbogast
authors.forename: T Lynne
authors.initials: TL
authors.lastname: Caples
authors.forename: Eli K
authors.initials: EK
authors.lastname: Po'e
authors.forename: William O
authors.initials: WO
authors.lastname: Cooper
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004358:Drug Therapy; D004363:Drug Utilization; D005260:Female; D006205:Haiti; D006801:Humans; D007231:Infant, Newborn; D016595:Misoprostol; D011247:Pregnancy; D011256:Pregnancy Outcome; D012044:Regression Analysis; D012651:Self Medication; D013723:Teratogens; D013754:Tetracyclines
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D013723:Teratogens; D013754:Tetracyclines; D016595:Misoprostol