title: Formation and study of single metal ion-phospholipid complexes in biphasic electrospray ionization mass spectrometry.
abstract: Single metal ion-phospholipid complexes are observed in biphasic electrospray ionization mass spectrometry (BESI-MS) using a dual-channel microsprayer. Such a microsprayer makes it possible to put into contact two immiscible liquids within the Taylor cone. Thus, L-α-dipalmitoyl phosphatidylcholine (DPPC) dissolved in 1,2-dichloroethane (DCE) reacts with aqueous metal cations (M = Na(+), K(+), Ca(2+), Cu(2+), La(3+)) yielding the formation of [M-DPPC(n)](z+) complexes. The number of phospholipid molecules ranges from 1 to 4 for monovalent ions, to 8 for divalent and to more than 10 for trivalent ions respectively. The large number of ligands observed involves the formation of solvent free single ion-phospholipid complexes.
authors.affiliation: Laboratoire d'Electrochimie Physique et Analytique, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Michel
authors.initials: M
authors.lastname: Prudent
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Méndez
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Jana
authors.forename: Clémence
authors.initials: C
authors.lastname: Corminboeuf
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Girault
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D005025:Ethylene Dichlorides / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D005025:Ethylene Dichlorides; D012996:Solutions; D014867:Water; D015060:1,2-Dipalmitoylphosphatidylcholine