title: Microwave assisted one pot synthesis of some novel 2,5-disubstituted 1,3,4-oxadiazoles as antifungal agents.
abstract: Sodium bisulfite has been reported first time for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole using microwave and conventional method in ethanol-water. The yields obtained are in the range of 90-95% using microwave and 87-91% using conventional method. All the synthesized compounds (8a-8s) are novel and were evaluated for their in vitro antifungal activity. SAR for the series has been developed by comparing their MIC values with miconazole and fluconazole. Some of the compounds from the series like 8k was equipotent with miconazole against Candida albicans and Fusarium oxysporum. Also compound 8n was equipotent with miconazole against F. oxysporum.
authors.affiliation: Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS, India.
authors.forename: Jaiprakash N
authors.initials: JN
authors.lastname: Sangshetti
authors.forename: Aniruddha R
authors.initials: AR
authors.lastname: Chabukswar
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002384:Catalysis; D015725:Fluconazole / Q000737:chemistry / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D008825:Miconazole / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013447:Sulfites / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D010069:Oxadiazoles; D013447:Sulfites; D008825:Miconazole; D015725:Fluconazole; C009279:sodium bisulfite