title: Primary lung adenocarcinoma associated with anti-Jo-1 positive polymyositis.
abstract: We present a female with anti-Jo-1 positive polymyositis and lung adenocarcinoma. Her polymyositis diagnosis was based on her clinical symptoms, electromyography results, and highly elevated muscle enzymes, including creatine kinase and lactate-dehydrogenase. Anti-Jo-1 positivity, leukocytosis and elevated tumor markers: CA 15-3 and CA 72-4 were also certified at the diagnosis. Her malignancy was finally diagnosed by transthoracic needle biopsy, two years after the appearance of first symptoms of polymyositis. After surgical removal of the tumor, polymyositis was in remission. Due to the symptoms mentioned above and the coincidence of the tumor, a paraneoplastic myositis was suspected.
authors.affiliation: 3rd Dept of Internal Medicine, Division of Immunology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary.
authors.forename: Melinda
authors.initials: M
authors.lastname: Vincze
authors.forename: Peter A
authors.initials: PA
authors.lastname: Molnár
authors.forename: Erika
authors.initials: E
authors.lastname: Zilahi
authors.forename: Anikó
authors.initials: A
authors.lastname: Kapitány
authors.forename: Balázs
authors.initials: B
authors.lastname: Dezso
authors.forename: István
authors.initials: I
authors.lastname: Takács
authors.forename: Katalin
authors.initials: K
authors.lastname: Dankó
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D017285:Polymyositis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C083825:CA-72-4 antigen; C046750:Jo-1 antibody; D018396:Mucin-1