title: [Evaluation of immune status of kidney transplant recipients by combined HLA-G5 and sCD30].
abstract: OBJECTIVE
  to study the relationship between the expression of serum human leucocyte antigen-G5 (HLA-G5)/soluble CD30 (sCD30) and the function of renal graft in kidney transplant recipients and investigate the immune status of recipients with combined HLA-G5 and sCD30.
  
  
  METHODS
  from January 2002 to November 2008, a total of 66 kidney transplant recipients in our centre were selected as subjects and divided into three groups: stable function of renal graft (n = 38), acute rejection (n = 15) and chronic rejection (n = 13). The expressions of serum HLA-G5 and sCD30 were detected. There were two different immune conditions with acute/chronic allograft rejection and normal renal graft in kidney transplant recipients as evaluated by combined HLA-G5 and sCD30. The sensitivity, specificity and critical value of the method were analyzed by the curve of receiver operating characteristic.
  
  
  RESULTS
  the levels of HLA-G5 and sCD30 were significantly correlated with serum creatinine (r = -0.493, 0.691, both P < 0.01). Within the first year post-transplantation, the sensitivity was 78.6% and the specificity 85.7% when HLA-G5 critical value 82 microg/L and sCD30 critical value 12.2 microg/L. After one year post-transplantation: the sensitivity was 92.3% and the specificity 84.6% when HLA-G5 critical value 141 microg/L and sCD30 critical value 10.3 microg/L.
  
  
  CONCLUSIONS
  the immune state of recipients are evaluated by combine HLA-G5 and sCD30 which may be a simple and valid method.
authors.affiliation: Department of Kidney Transplantation, Central of Nephropathy, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Zhan-kui
authors.initials: ZK
authors.lastname: JIN
authors.forename: Pu-xun
authors.initials: PX
authors.lastname: TIAN
authors.forename: Wu-jun
authors.initials: WJ
authors.lastname: XUE
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: DING
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: PAN
authors.forename: Chen-guang
authors.initials: CG
authors.lastname: DING
authors.forename: Li-ning
authors.initials: LN
authors.lastname: JIA
authors.forename: Guan-qun
authors.initials: GQ
authors.lastname: GE
authors.forename: Jun-jun
authors.initials: JJ
authors.lastname: HAO
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006680:HLA Antigens / Q000097:blood* / Q000276:immunology; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000097:blood* / Q000276:immunology; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood* / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D017730:Ki-1 Antigen