title: Breakthrough Saprochaete capitata infections in patients receiving echinocandins: case report and review of the literature.
abstract: We report a rare case of a fatal Saprochaete capitata breakthrough infection in a patient with acute myeloid leukemia receiving empirical caspofungin therapy. S. capitata is an uncommon, yet emerging cause of invasive infections, especially in patients with haematological malignancies. Blood cultures from our patient yielded S. capitata which was found to be resistant, in vitro, to caspofungin. We consecutively reviewed all published cases of breakthrough infections caused by S. capitata in patients receiving echinocandins. S. capitata should be considered in those patients who remain febrile or who develop invasive mould infections while under echinocandin therapy.
authors.affiliation: Department of Hematology, GZA St. Augustinus, Wilrijk, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Schuermans
authors.forename: M
authors.initials: M
authors.lastname: van Bergen
authors.forename: L
authors.initials: L
authors.lastname: Coorevits
authors.forename: J
authors.initials: J
authors.lastname: Verhaegen
authors.forename: K
authors.initials: K
authors.lastname: Lagrou
authors.forename: I
authors.initials: I
authors.lastname: Surmont
authors.forename: A
authors.initials: A
authors.lastname: Jeurissen
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D000077336:Caspofungin; D002648:Child; D054714:Echinocandins / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D005847:Geotrichosis / Q000150:complications / Q000188:drug therapy*; D005848:Geotrichum / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000382:microbiology*; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole