title: Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function.
abstract: BACKGROUND
  Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF.
  
  
  METHODS
  We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF.
  
  
  RESULTS
  Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74).
  
  
  CONCLUSIONS
  This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.
authors.affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. nalachk1@jhmi.edu
authors.forename: N
authors.initials: N
authors.lastname: Alachkar
authors.forename: R
authors.initials: R
authors.lastname: Ugarte
authors.forename: E
authors.initials: E
authors.lastname: Huang
authors.forename: K L
authors.initials: KL
authors.lastname: Womer
authors.forename: R
authors.initials: R
authors.lastname: Montgomery
authors.forename: E
authors.initials: E
authors.lastname: Kraus
authors.forename: H
authors.initials: H
authors.lastname: Rabb
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015142:Baltimore; D015415:Biomarkers / Q000097:blood / Q000652:urine; D051799:Delayed Graft Function / Q000097:blood / Q000209:etiology* / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D019410:Interleukin-16 / Q000097:blood* / Q000652:urine; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood*; D007674:Kidney Diseases / Q000097:blood / Q000209:etiology* / Q000652:urine; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015427:Reperfusion Injury / Q000097:blood / Q000209:etiology* / Q000652:urine; D019089:Stem Cell Factor / Q000097:blood* / Q000652:urine; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C508017:IL2RA protein, human; D007166:Immunosuppressive Agents; D019410:Interleukin-16; D053645:Interleukin-2 Receptor alpha Subunit; D019089:Stem Cell Factor