title: Role of 4-hydroxy-trans-2-nonenal in cell functions.
abstract: The role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis. 4-HNE and metabolic products of other antioxidants (carotenoids) resemble each other in chemical nature of the product and influence general pathways of signal transduction. Manifestation of 4-HNE toxicity under oxidative stress conditions is regarded as a link to many diseases whose pathogenesis is connected with modifications of proteins and nucleic acids.
authors.affiliation: Bekhterev St. Petersburg Psychoneurological Research Institute, St. Petersburg, 192019, Russia. eedubinina@rambler.ru
authors.forename: E E
authors.initials: EE
authors.lastname: Dubinina
authors.forename: V A
authors.initials: VA
authors.lastname: Dadali
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D017209:Apoptosis; D002338:Carotenoids / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D000447:Aldehydes; D002338:Carotenoids; D005978:Glutathione; C027576:4-hydroxy-2-nonenal