title: Induced production of bromomethylchlamydosporols A and B from the marine-derived fungus Fusarium tricinctum.
abstract: The addition of CaBr(2) to the fermentation of a marine-derived Fusarium tricinctum resulted in production of halogenated chlamydosporol analogues. Two new antimicrobial halogenated pyranopyranones, bromomethylchlamydosporols A (1) and B (2), and two known compounds, chlamydosporol (an inseparable epimeric mixture of 7R:7S = 1:1 from (1)H NMR data) (3) and fusarielin A (4), were isolated from the culture. The structures of 1 and 2 were assigned through a combination of spectroscopic data analyses. Compounds 1-4 exhibited mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC values of each strain were as follows: compounds 1 and 2 showed an MIC of 15.6 μg/mL against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus, and compounds 3 and 4 exhibited an MIC of 31.5 μg/mL against S. aureus and methicillin-resistant S. aureus and 62.5 μg/mL against multidrug-resistant S. aureus.
authors.affiliation: Department of Chemistry, Pukyong National University, Busan, Korea.
authors.forename: Viviane
authors.initials: V
authors.lastname: Nenkep
authors.forename: Keumja
authors.initials: K
authors.lastname: Yun
authors.forename: Dahai
authors.initials: D
authors.lastname: Zhang
authors.forename: Hong Dae
authors.initials: HD
authors.lastname: Choi
authors.forename: Jung Sook
authors.initials: JS
authors.lastname: Kang
authors.forename: Byeng Wha
authors.initials: BW
authors.lastname: Son
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005670:Fusarium / Q000737:chemistry* / Q000378:metabolism; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D006842:Hydrocarbons, Brominated; D011753:Pyrones; C555086:bromomethylchlamydosporol A; C555087:bromomethylchlamydosporol B