title: Divergent route to access structurally diverse 4-quinolones via mono or sequential cross-couplings.
abstract: A divergent route was developed to access 3-iodo- and 6-chloro-3-iodo-4(1H)-quinolones for further elaboration via mono and/or sequential Suzuki-Miyaura cross-coupling to generate novel and medicinally important 4(1H)-quinolones. Copper- and palladium-catalyzed cyanations were used to functionalize the 4-quinolone core further.
authors.affiliation: Department of Chemistry, University of South Florida, CHE205, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
authors.forename: R Matthew
authors.initials: RM
authors.lastname: Cross
authors.forename: Roman
authors.initials: R
authors.lastname: Manetsch
mesh_terms: D042462:4-Quinolones / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D042462:4-Quinolones; D003432:Cross-Linking Reagents; D010165:Palladium; D003300:Copper