title: High-resolution cardiac MRI using partially separable functions and weighted spatial smoothness regularization.
abstract: Imaging of cardiac morphology and functions in high spatiotemporal resolution using MRI is a challenging problem due to limited imaging speed and the inherent tradeoff between spatial resolution, temporal resolution, and signal-to-noise ratio (SNR). The partially separable function (PSF) model has been shown to achieve high spatiotemporal resolution but can lead to noisy reconstructions. This paper proposes a method to improve the SNR and reduce artifacts in PSF-based reconstructions through the use of anatomical constraints. These anatomical constraints are obtained from a high-SNR image of composite (k, t)-space data (summed along the time axis) and used to regularize the PSF reconstruction. The method has been evaluated on experimental data of rat hearts to achieve 390 εm in-plane resolution and 15 ms temporal resolution.
authors.affiliation: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, Urbana, IL 61801, USA.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Christodoulou
authors.forename: Cornelius
authors.initials: C
authors.lastname: Brinegar
authors.forename: Justin P
authors.initials: JP
authors.lastname: Haldar
authors.forename: Haosen
authors.initials: H
authors.lastname: Zhang
authors.forename: Yi-Jen L
authors.initials: YJ
authors.lastname: Wu
authors.forename: Lesley M
authors.initials: LM
authors.lastname: Foley
authors.forename: T
authors.initials: T
authors.lastname: Hitchens
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Chien
authors.initials: C
authors.lastname: Ho
authors.forename: Zhi-Pei
authors.initials: ZP
authors.lastname: Liang
mesh_terms: D000465:Algorithms; D000818:Animals; D006321:Heart / Q000033:anatomy & histology*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity