title: Effect of Ce(III) on heat production of mitochondria isolated from hybrid rice.
abstract: The effect of cerium on mitochondria isolated from hybrid rice Shanyou 63 (Oryza sativa L) was investigated. Through in vivo culture, low dose Ce3+ promoted, but higher dose Ce3+, restrained mitochondrial heat production. However, through vitro incubation, Ce3+ showed only inhibitory action on mitochondrial energy turnover, the concentration required for 50% inhibition being 46.7 μM. In addition, Ce3+, like Ca2+, induced rice mitochondrial swelling and decreased membrane potential (△ψ), which was inhibited by the specific permeability transition inhibitor cyclosporine A (CsA). The induction approached a constant level while mitochondrial metabolism was fully prevented by Ce3+. These results demonstrated that cerium influenced rice mitochondria in vivo and in vitro via different action pathways, and the latter involved the opening of rice mitochondrial permeability.
authors.affiliation: College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, Hubei, 434023, China. yxy0910@yahoo.com.cn
authors.forename: Jie
authors.initials: J
authors.lastname: Dai
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Liu
authors.forename: Gui-Qing
authors.initials: GQ
authors.lastname: Zhou
authors.forename: Ye-Zhong
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D002563:Cerium / Q000494:pharmacology*; D016572:Cyclosporine / Q000494:pharmacology; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D012275:Oryza / Q000187:drug effects* / Q000378:metabolism*; D022722:Thermogenesis / Q000187:drug effects
chemical_list: D002563:Cerium; D016572:Cyclosporine