title: Non-thermal irreversible electroporation for deep intracranial disorders.
abstract: Non-thermal irreversible electroporation (N-TIRE) is a new minimally invasive technique to kill undesirable tissue. We build on our previous intracranial studies in order to evaluate the possibility of using N-TIRE for deep intracranial disorders. In this manuscript we describe a minimally invasive computed tomography (CT) guided N-TIRE procedure in white matter. In addition, we report the electric field threshold needed for white matter ablation (630 - 875 V/cm) using four sets of twenty 50 µs pulses at a voltage-to-distance ratio of 1000 V/cm. We also confirm the non-thermal aspect of the technique with real time temperature data measured at the electrode-tissue interface.
authors.affiliation: Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA. pgarcia@vt.edu
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Garcia
authors.forename: Robert E
authors.initials: RE
authors.lastname: Neal
authors.forename: John H
authors.initials: JH
authors.lastname: Rossmeisl
authors.forename: Rafael V
authors.initials: RV
authors.lastname: Davalos
mesh_terms: D000465:Algorithms; D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000628:therapy* / Q000662:veterinary; D017115:Catheter Ablation / Q000379:methods*; D003201:Computers; D003337:Corpus Callosum / Q000473:pathology; D004285:Dogs; D004566:Electrodes; D018274:Electroporation / Q000379:methods*; D008495:Medical Oncology / Q000379:methods; D008962:Models, Theoretical; D013696:Temperature; D014057:Tomography, X-Ray Computed / Q000379:methods