title: The participation of a neurocircuit from the paraventricular thalamus to amygdala in the depressive like behavior.
abstract: Depression is a neuropsychological disease derived from genetic, biochemical, environmental, and psychological factors. However the neurocircuits involved in it are not clear. We introduced the forced swimming test (FST) as a model of the depressive like behavior. In our study, the participation of projections from paraventricular nucleus of the thalamus (PVT) in FST was detected. The retrograde tracing combined with immunofluorescent detection of c-fos was used. Our results showed that the FST greatly increased the c-fos level in PVT and the central amygdale (CE) neurons. These populations of activated neurons in the PVT and the CE were also labeled by the retrograde tracer FG injected in the CE, suggesting that the activation of PVT was involved in this depressive like behavior by relaying information to the CE.
authors.affiliation: General Surgery of Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
mesh_terms: D000679:Amygdala / Q000473:pathology*; D000704:Analysis of Variance; D000818:Animals; D003863:Depression / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D046353:Immobility Response, Tonic / Q000502:physiology; D008297:Male; D020644:Midline Thalamic Nuclei / Q000473:pathology*; D009434:Neural Pathways / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013266:Stilbamidines / Q000378:metabolism; D013550:Swimming / Q000523:psychology
chemical_list: C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D016760:Proto-Oncogene Proteins c-fos; D013266:Stilbamidines