title: Ca²+ signaling in B cells.
abstract: An increase in intracellular Ca²+ concentration is one of the major initial steps in B-cell activation that occurs within minutes after antigen receptor (BCR) engagement. In recent years, significant advances have been made in characterizing molecular mechanisms of Ca²+ signaling in lymphocytes, although the majority of work was done on T cells. This mini-review discusses several underexplored areas of Ca²+ signaling in B cells: (1) Ca²+ signaling in immune synapse and multifaceted Ca²+ responses within a single cell, (2) source of Ca²+ involved in Ca²+-dependent protein phosphorylation events and the role of store-operated influx, (3) role of BCR coreceptors in Ca²+ signaling, and (4) Ca²+ signaling and maintenance of B-cell tolerance and clinical significance of Ca²+ signaling alterations.
authors.affiliation: Department of Medicine, University of Colorado Denver School of Medicine, USA. taras.lyubchenko@ucdenver.edu
authors.forename: Taras
authors.initials: T
authors.lastname: Lyubchenko
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D051966:Phospholipase C gamma; D010766:Phosphorylation; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D017464:Receptors, Complement 3d / Q000378:metabolism
chemical_list: D011947:Receptors, Antigen, B-Cell; D017464:Receptors, Complement 3d; D051966:Phospholipase C gamma; D002118:Calcium