title: The structure of the Escherichia coli O148 lipopolysaccharide core region and its linkage to the O-specific polysaccharide.
abstract: Recently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a glucose residue in E. coli O148. Herein, we analyzed the core structure and its linkage to the O-SP in E. coli O148 LPS. Both were found to be identical to those of S. dysenteriae type 1 structures, further supporting the relatedness of these two bacteria. The following structure of the core with one repeat unit of the O-SP has been assigned (all have d-configuration except l-Rha):
authors.affiliation: National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kubler-Kielb
authors.forename: Wen-Tzu
authors.initials: WT
authors.lastname: Lai
authors.forename: Rachel
authors.initials: R
authors.lastname: Schneerson
authors.forename: Evgeny
authors.initials: E
authors.lastname: Vinogradov
mesh_terms: D002240:Carbohydrate Sequence; D004926:Escherichia coli / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D019081:O Antigens / Q000737:chemistry*
chemical_list: D008070:Lipopolysaccharides; D019081:O Antigens