title: FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system.
abstract: FlyFactorSurvey (http://pgfe.umassmed.edu/TFDBS/) is a database of DNA binding specificities for Drosophila transcription factors (TFs) primarily determined using the bacterial one-hybrid system. The database provides community access to over 400 recognition motifs and position weight matrices for over 200 TFs, including many unpublished motifs. Search tools and flat file downloads are provided to retrieve binding site information (as sequences, matrices and sequence logos) for individual TFs, groups of TFs or for all TFs with characterized binding specificities. Linked analysis tools allow users to identify motifs within our database that share similarity to a query matrix or to view the distribution of occurrences of an individual motif throughout the Drosophila genome. Together, this database and its associated tools provide computational and experimental biologists with resources to predict interactions between Drosophila TFs and target cis-regulatory sequences.
authors.affiliation: Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
authors.forename: Lihua Julie
authors.initials: LJ
authors.lastname: Zhu
authors.forename: Ryan G
authors.initials: RG
authors.lastname: Christensen
authors.forename: Majid
authors.initials: M
authors.lastname: Kazemian
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hull
authors.forename: Metewo Selase
authors.initials: MS
authors.lastname: Enuameh
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Basciotta
authors.forename: Jessie A
authors.initials: JA
authors.lastname: Brasefield
authors.forename: Cong
authors.initials: C
authors.lastname: Zhu
authors.forename: Yuna
authors.initials: Y
authors.lastname: Asriyan
authors.forename: David S
authors.initials: DS
authors.lastname: Lapointe
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sinha
authors.forename: Scot A
authors.initials: SA
authors.lastname: Wolfe
authors.forename: Michael H
authors.initials: MH
authors.lastname: Brodsky
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics; D001665:Binding Sites; D030541:Databases, Genetic; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000378:metabolism*; D050436:Regulatory Elements, Transcriptional; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*; D020798:Two-Hybrid System Techniques; D014584:User-Computer Interface
chemical_list: D029721:Drosophila Proteins; D014157:Transcription Factors