title: Effect of omega-3 fatty acids on plasma level of 8-isoprostane in kidney transplant patients.
abstract: OBJECTIVE
  It has been shown previously that the serum level of F2-isoprostanes acts as an indicator of oxidative stress, which is a risk factor for vascular disease especially in end-stage renal disease. It is not known whether n-3 polyunsaturated fatty acids can decrease oxidative stress in renal recipient patients.
  
  
  METHODS
  In this single blind, randomized, placebo-controlled study, the effect of 3 and 6 months of fish oil administration on 8-isoprostane levels in renal transplant recipients was evaluated.
  
  
  METHODS
  Twenty-two renal transplant patients who fulfilled inclusion and exclusion criteria randomly received either fish oil dietary supplementation, 6 g/day (720 mg of DHA and 1,080 mg of EPA) or placebo for 6 months.
  
  
  METHODS
  Serum 8-isoprostane concentration was measured as markers of oxidative stress.
  
  
  RESULTS
  A significant decrease in 8-isoprostane levels was observed only in the placebo group after transplantation compared to baseline (P < 0.05). However, the group receiving fish oil had a significantly lower cholesterol level than that of the placebo group (P < 0.05).
  
  
  CONCLUSIONS
  On the basis of our results, omega-3 fatty acids supplementation decreased the beneficial effects of kidney transplantation on oxidative stress.
authors.affiliation: Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. mohamadpoorah@mums.ac.ir
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ramezani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Nazemian
authors.forename: Jamal
authors.initials: J
authors.lastname: Shamsara
authors.forename: Reza
authors.initials: R
authors.lastname: Koohrokhi
authors.forename: Amir Hooshang
authors.initials: AH
authors.lastname: Mohammadpour
mesh_terms: D000328:Adult; D015237:Dinoprost / Q000031:analogs & derivatives; D028441:F2-Isoprostanes / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D028441:F2-Isoprostanes; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost