title: Diversity of the early step of the futalosine pathway.
abstract: We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H. pylori drugs.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Arakawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kuratsu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Furihata
authors.forename: Tomoshige
authors.initials: T
authors.lastname: Hiratsuka
authors.forename: Nobuya
authors.initials: N
authors.lastname: Itoh
authors.forename: Haruo
authors.initials: H
authors.lastname: Seto
authors.forename: Tohru
authors.initials: T
authors.lastname: Dairi
mesh_terms: D000225:Adenine / Q000737:chemistry; D001419:Bacteria / Q000201:enzymology / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D016480:Helicobacter pylori / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D006867:Hydrolases / Q000235:genetics / Q000378:metabolism*; D019271:Hypoxanthine / Q000378:metabolism; D009705:Nucleosides / Q000737:chemistry / Q000378:metabolism*; D016963:Thermus thermophilus / Q000201:enzymology / Q000378:metabolism; D024482:Vitamin K 2 / Q000378:metabolism
chemical_list: D009705:Nucleosides; C122040:futalosine; D024482:Vitamin K 2; D019271:Hypoxanthine; D006867:Hydrolases; D000225:Adenine