title: Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines.
abstract: OBJECTIVE
  To evaluate the anti-Helicobacter pylori (H. pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.
  
  
  METHODS
  A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H. pylori Sydney strain 1 was performed with broth dilution method. Anti-H. pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).
  
  
  RESULTS
  The water extract from Rhizoma Coptidis, Radix Scutellariae and Radix isatidis could significantly inhibit the H. pylori activity with their MIC less than 7.8 mg/mL, suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H. pylori infection.
  
  
  CONCLUSIONS
  Rhizoma Coptidis, Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H. pylori.
authors.affiliation: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Tonghe Road 1838, Guangzhou 510515, Guangdong Province, China. baiyang1030@hotmail.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Ma
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Qing
authors.forename: Ji-De
authors.initials: JD
authors.lastname: Wang
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Bei-Guo
authors.initials: BG
authors.lastname: Long
authors.forename: Yang
authors.initials: Y
authors.lastname: Bai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal