title: Thermo-responsive polymer brushes as intelligent biointerfaces: preparation via ATRP and characterization.
abstract: PIPAAm-brush grafted glass substrates with various graft densities and chain lengths were prepared via surface-initiated ATRP. Temperature-dependent physicochemical properties of the surfaces were characterized by means of ATR/FT-IR spectroscopy, XPS, AFM, and contact angle measurements. ATRP conditions influence the amount of grafted PIPAAm and the surface wettability and roughness of the substrate. Fibronectin adsorption and EC adhesion increased with decreasing density of PIPAAm brushes. EC adhesion was diminished with increasing PIPAAm graft length. Thus, the preparation of PIPAAm brush surface with various graft densities and chain lengths using the surface-initiated ATRP is an effective method for modulating thermo-responsive properties of surfaces.
authors.affiliation: Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University TWIns, 8-1 Kawadacho, Shinjuku, Tokyo 162-8666, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nagase
authors.forename: Minami
authors.initials: M
authors.lastname: Watanabe
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kikuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamato
authors.forename: Teruo
authors.initials: T
authors.lastname: Okano
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000327:Adsorption / Q000187:drug effects; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002339:Carotid Arteries / Q000166:cytology; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D005353:Fibronectins / Q000494:pharmacology; D005898:Glass; D008422:Materials Testing / Q000379:methods*; D018625:Microscopy, Atomic Force; D056951:Photoelectron Spectroscopy; D058105:Polymerization / Q000187:drug effects; D013499:Surface Properties / Q000187:drug effects; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D005353:Fibronectins; C052970:poly-N-isopropylacrylamide