title: Development of a new polypropylene-based suture: plasma grafting, surface treatment, characterization, and biocompatibility studies.
abstract: Polypropylene sutures (PP) are already used in surgery. Because microbial infection leads to complications, we developed antimicrobial PP suture by plasma-induced graft polymerization of acrylic acid followed by chitosan binding on the remaining carboxyl groups. Mechanical properties and surface morphologies were analyzed on these sutures. Tetracycline hydrochloride (TC) or nanosilver (NS) was then immobilized to PP. The resulting PP sutures evidenced drug release properties and antimicrobial activity in vitro. PP implanted in vivo for 30 days in the muscle of rats showed the absence of adverse effects and a tissue organization. This new polypropylene suture with suitable antimicrobial features appears to be a promising macromolecular material for clinical and cosmetic applications.
authors.affiliation: Centre for Biomedical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi-110016, India.
authors.forename: Shalini
authors.initials: S
authors.lastname: Saxena
authors.forename: Alok R
authors.initials: AR
authors.lastname: Ray
authors.forename: Arti
authors.initials: A
authors.lastname: Kapil
authors.forename: Graciela
authors.initials: G
authors.lastname: Pavon-Djavid
authors.forename: Didier
authors.initials: D
authors.lastname: Letourneur
authors.forename: Bhuvanesh
authors.initials: B
authors.lastname: Gupta
authors.forename: Anne
authors.initials: A
authors.lastname: Meddahi-Pellé
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D008297:Male; D008422:Materials Testing / Q000379:methods*; D055595:Mechanical Phenomena / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D058626:Plasma Gases / Q000737:chemistry*; D011126:Polypropylenes / Q000138:chemical synthesis* / Q000737:chemistry; D019919:Prosthesis Implantation; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties / Q000187:drug effects; D013537:Sutures; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D058626:Plasma Gases; D011126:Polypropylenes; D048271:Chitosan; D013752:Tetracycline