title: Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes.
abstract: Platelet transfusion is one of the most crucial therapeutic approaches in Medicine. However, severe and fatal adverse reactions may develop. In addition to their important function in hemostasis, platelets' role in inflammation has become more evident. Recently, platelets are also recognized as the main source of circulating soluble CD40 ligand (sCD40L, (CD154)), which plays significant roles in hemostasis, platelet activation, clot stability, interactions with other cells, and upregulation of different mediators. In this review, we will briefly highlight the importance of platelet transfusion, its role in inflammatory and thrombotic transfusion reactions, and visit the most recent findings on sCD40L.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642,USA. majed_refaai@urmc.rochester.edu
authors.forename: Majed A
authors.initials: MA
authors.lastname: Refaai
authors.forename: Richard P
authors.initials: RP
authors.lastname: Phipps
authors.forename: Sherry L
authors.initials: SL
authors.lastname: Spinelli
authors.forename: Neil
authors.initials: N
authors.lastname: Blumberg
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000276:immunology; D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000276:immunology; D017713:Platelet Transfusion / Q000009:adverse effects*; D013927:Thrombosis / Q000209:etiology* / Q000276:immunology
chemical_list: D023201:CD40 Ligand