title: No association of psychosis in Alzheimer disease with neurodegenerative pathway genes.
abstract: Psychotic symptoms occur in approximately 40% of subjects with Alzheimer disease (AD with psychosis; AD + P) and identify a subgroup with more rapid cognitive decline. We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amyloid beta (Aβ) protein and/or hyperphosphorylated microtubule-associated protein tau (MAPT): amyloid precursor protein (APP), beta-site amyloid precursor protein cleaving enzyme (BACE1), sortilin-related receptor (SORL1), and MAPT. Each gene was thoroughly interrogated with tag single-nucleotide polymorphisms (SNPs), and gene-based tests were used to enhance power. We found no association of these genes with AD + P.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Mary Ann A
authors.initials: MA
authors.lastname: DeMichele-Sweet
authors.forename: Lambertus
authors.initials: L
authors.lastname: Klei
authors.forename: Bernie
authors.initials: B
authors.lastname: Devlin
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: Elise A
authors.initials: EA
authors.lastname: Weamer
authors.forename: James E
authors.initials: JE
authors.lastname: Emanuel
authors.forename: Oscar L
authors.initials: OL
authors.lastname: Lopez
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sweet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics; D053829:Amyloid Precursor Protein Secretases / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D016282:Aspartic Acid Endopeptidases / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D009410:Nerve Degeneration / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000209:etiology / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D026502:LDL-Receptor Related Proteins; C054369:MAPT protein, human; D026901:Membrane Transport Proteins; C102582:SORL1 protein, human; D016875:tau Proteins; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human