title: [Four resected cases with basaloid carcinoma of esophagus--comparison of 5-FU-related enzymes (thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyl transferase (OPRT)) between basaloid carcinoma and squamous cell carcinoma].
abstract: We reported herein four resected cases with basaloid carcinoma of the esophagus and measured the activity of 5-FU related enzymes (TS, DPD, OPRT) in cancer tissue. These activities compared with those in squamous cell carcinoma. Only one case was diagnosed as basaloid carcinoma by preoperative biopsy specimen at endoscopic examination. The esophagectomy was performed thoracoscopically in all cases, and the abdominal procedure was done with the laparoscopic approach in two cases. Anastomotic leakage occurred in one case. No case had lymph node metastasis. On the other hand, a lymphatic invasion was detected in one case, and venous invasion in two, respectively. Two cases had mediastinal lymph node recurrence. DPD activity and OPRT activity showed no difference between squamous cell carcinoma and basaloid carcinoma. On the other hand, the TS activity was significantly higher in basaloid carcinoma. From the standpoint of 5-FU-related enzyme activities, basaloid carcinoma possibly has more resistance to 5-FU than squamous cell carcinoma.
authors.affiliation: Dept. of Upper Gastrointestinal Surgery, Hyogo College of Medicine.
authors.forename: Masashi
authors.initials: M
authors.lastname: Takemura
authors.forename: Keiichirou
authors.initials: K
authors.lastname: Morimura
authors.forename: Kayo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Yushi
authors.initials: Y
authors.lastname: Fujiwara
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000201:enzymology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000601:surgery; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000201:enzymology* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005472:Fluorouracil / Q000378:metabolism; D006801:Humans; D010535:Laparoscopy; D008208:Lymphatic System / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009962:Orotate Phosphoribosyltransferase / Q000378:metabolism*; D013906:Thoracoscopy; D013940:Thymidylate Synthase / Q000378:metabolism*
chemical_list: D000964:Antimetabolites, Antineoplastic; D042943:Dihydrouracil Dehydrogenase (NADP); D013940:Thymidylate Synthase; D009962:Orotate Phosphoribosyltransferase; D005472:Fluorouracil