The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.
Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.
University of California, San Francisco, CA 94158, USA. cynthia.kenyon@ucsf.edu
Cynthia
C
Kenyon
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology*; D007328:Insulin / Q000235:genetics / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D015398:Signal Transduction
D007328:Insulin; D007334:Insulin-Like Growth Factor I