Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma.
Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis.
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia. snayyad2@yahoo.com
Seif-Eldin N
SE
Ayyad
Mohamed S
MS
Makki
Nazeeha S
NS
Al-Kayal
Salim A
SA
Basaif
Kalid O
KO
El-Foty
Abdullah M
AM
Asiri
Walied M
WM
Alarif
Farid A
FA
Badria
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D052160:Benzothiazoles / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004249:DNA Damage; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D000459:Phaeophyceae / Q000737:chemistry*; D013451:Sulfonic Acids / Q000494:pharmacology; D014709:Vero Cells
D000970:Antineoplastic Agents; D000975:Antioxidants; D052160:Benzothiazoles; D004224:Diterpenes; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid