The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine.
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a syndrome characterized by pulmonary edema and acute inflammation. Lipopolysaccharide (LPS), a major component in Gram-negative bacteria, has been used to induce ALI/ARDS. LPS-induced animal models highlight ways to explore mechanisms of multiple diseases and provide useful information on the discovery of novel biomarkers and drug targets. However, each model has its own merits and drawbacks. The goal of this article is to summarize and evaluate the results of experimental findings in LPS-induced ALI/ARDS, and the possible mechanisms and treatments elucidated. Advantages and disadvantages of such models in pulmonary research and new directions for future investigations are also discussed.
Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Hong
H
Chen
Chunxue
C
Bai
Xiangdong
X
Wang
D055371:Acute Lung Injury / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008070:Lipopolysaccharides; D008168:Lung / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D015272:Pulmonary Medicine / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D015398:Signal Transduction; D013045:Species Specificity
D018836:Inflammation Mediators; D008070:Lipopolysaccharides