Perspectives on endocrine disruptor effects on metabolic sensors.
Endocrine disrupting (EDs) chemicals can increase or block the metabolism of endogenous peptidergic or steroid hormones by activating or antagonizing nuclear receptors in the hypothalamus, besides adipose tissue, liver and gonads. Toxicological and epidemiological studies have suggested the involvement of different EDs in an increasing number of metabolic disorders such as obesity and diabetes. The aim of this review is to summarize the literature from experimental animal studies demonstrating the impairment of body weight raised by the deregulation of peptidergic signals as well as by the activation of key metabolic molecular targets. Regarding the modification of gene transcription levels induced by EDs, new data on DEHP effect on food intake and lipid metabolism in the experimental model zebrafish (Danio rerio) have also been included in this review providing evidences about the dangerousness of DEHP low doses.
Dipartimento di Scienze del Mare, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.
B
B
Migliarini
C C
CC
Piccinetti
A
A
Martella
F
F
Maradonna
G
G
Gioacchini
O
O
Carnevali
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000633:toxicity; D004435:Eating / Q000187:drug effects; D052244:Endocrine Disruptors / Q000633:toxicity*; D006728:Hormones / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D050356:Lipid Metabolism / Q000187:drug effects; D008659:Metabolic Diseases / Q000209:etiology / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013256:Steroids / Q000378:metabolism; D015027:Zebrafish
D052244:Endocrine Disruptors; D006728:Hormones; D011956:Receptors, Cell Surface; D013256:Steroids; D004051:Diethylhexyl Phthalate