A review on the putative association between beta-blockers and depression.
Several kinds of systematic studies have been conducted verifying the putative association between β-blockers and depressive symptoms. However, many of these studies had important limitations in their design. In most of the studies, no effect of β-blockers on depressive symptoms was seen. Because individual susceptibility cannot be ruled out, clinicians must stay vigilant, especially with patients who have a positive personal or family history and who have been prescribed lipophilic β-blockers. However, fear for depression should not be the reason for reluctance in prescribing β-blockers to cardiovascular patients.
Department of Internal Medicine, Ziekenhuisgroep Twente, Almelo, The Netherlands. verbeek.dep@gmail.com
Daniëlle E P
DE
Verbeek
Jerry
J
van Riezen
Rudolf A
RA
de Boer
Joost P
JP
van Melle
Peter
P
de Jonge
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D003863:Depression / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology; D018450:Disease Progression; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy; D006801:Humans; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
D000319:Adrenergic beta-Antagonists