Long-term intraperitoneal injection of lipopolysaccharide induces high expression of Id2 in the brain of mice.
Lipopolysaccharide (LPS) from gram negative bacteria plays an important role in the pathophysiology of neurodegenerative diseases. Many evidences showed that LPS-induced neuroinflammation is related to upregulation of NF-kappaB. Here, we report that long-term treatment of lower dosage LPS mainly causes upregulation of Id2 protein. As an inhibitor of cell differentiation, Id2 plays an import role in adult olfactory neurogenesis. However, Id2 protein in brain acts as two edges in a sword, persist over-expression of Id2 in brain can induce neurodamages and may be related to neurodegeneration.
Department of Anatomy, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Le-Yu
LY
Wang
Zeng-zhi
ZZ
Niu
Bian-xiang
BX
Hu
Jia-ming
JM
Wu
Xuan
X
Jiang
Xiao-fang
XF
Hu
Wen-hua
WH
Huang
Jun
J
Ouyang
Lei
L
Yu
Xiao-Zhong
XZ
Qiu
D000818:Animals; D001562:Benzimidazoles / Q000378:metabolism; D015153:Blotting, Western; D001921:Brain / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D051797:Inhibitor of Differentiation Protein 2 / Q000235:genetics / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000008:administration & dosage* / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011419:Propidium / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors
D001562:Benzimidazoles; C497452:Idb2 protein, mouse; D051797:Inhibitor of Differentiation Protein 2; D008070:Lipopolysaccharides; D011419:Propidium; C017807:bisbenzimide ethoxide trihydrochloride