Effect of deprenyl on free radical oxidation in rat brain during immobilization stress.
Rarely repeated episodes of 1-h immobilization in rats were accompanied by an increase in the content of molecular products of lipid peroxidation and decrease in the amount of oxidatively modified proteins. Monoamine oxidase B inhibitor deprenyl prevented the poststress activation of lipid peroxidation.
Chelyabinsk State Medical Academy, Russian Ministry of Health, Russia. vadimed@yandex.ru
V E
VE
Tseilikman
A I
AI
Sinitsky
K A
KA
Poyarkov
E V
EV
Vojdaev
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012149:Restraint, Physical; D012642:Selegiline / Q000494:pharmacology*; D013312:Stress, Physiological / Q000502:physiology
D004791:Enzyme Inhibitors; D005609:Free Radicals; D012642:Selegiline; D008995:Monoamine Oxidase