Co-evolution is incompatible with the Markov assumption in phylogenetics.
Markov models are extensively used in the analysis of molecular evolution. A recent line of research suggests that pairs of proteins with functional and physical interactions co-evolve with each other. Here, by analyzing hundreds of orthologous sets of three fungi and their co-evolutionary relations, we demonstrate that co-evolutionary assumption may violate the Markov assumption. Our results encourage developing alternative probabilistic models for the cases of extreme co-evolution.
Faculty of Mathematics and Computer Science, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel. tamirtul@post.tau.ac.il
Tamir
T
Tuller
Elchanan
E
Mossel
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008390:Markov Chains; D010802:Phylogeny; D011506:Proteins / Q000235:genetics
D011506:Proteins