Dose response biology: the case of resveratrol.
Resveratrol often displays hormesis-like biphasic dose responses. This occurs in a broad range of biological models and for numerous endpoints of biomedical interest and public health concern. Recognition of the widespread occurrence of the hormetic nature of many of the responses of resveratrol is important on multiple levels. It can help optimize study design protocols by investigators, create a dose-response framework for better addressing dose-related biological complexities and assist in the development of public health and medical guidance with respect to considerations for what is an optimal dose not just for an agent such as resveratrol, but also for the plethora of agents that also act via hormetic mechanisms.
Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003,USA. edwardc@schoolph.umass.edu
Edward J
EJ
Calabrese
Mark P
MP
Mattson
Vittorio
V
Calabrese
D000818:Animals; D035843:Biomedical Research; D004305:Dose-Response Relationship, Drug; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology
D013267:Stilbenes; D000077185:Resveratrol