Thrombocytopenia after vaccination: case reports to the US Vaccine Adverse Event Reporting System, 1990-2008.
We reviewed thrombocytopenia (TP) reports to the US Vaccine Adverse Event Reporting System (VAERS). We examined TP patterns for differences in single versus multiple immunization reports, presence of a live viral vaccine, seriousness, age, and interval to symptom onset. We found 1510 reports of possible TP and after exclusions evaluated 1440 for possible causes. Most (1078; 75%) met the regulatory definition of a serious adverse event. TP was reported after inactivated and live viral vaccines. Platelet counts <10×10(9)/L were reported. Identified vaccines could be prioritized for hypothesis-testing studies.
Food and Drug Administration, FDA/CBER/OBE, Rockville, MD 20852, USA. jane.woo@fda.hhs.gov
Emily Jane
EJ
Woo
Robert P
RP
Wise
David
D
Menschik
Sean V
SV
Shadomy
John
J
Iskander
Judy
J
Beeler
Frederick
F
Varricchio
Robert
R
Ball
D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000453:epidemiology*; D014481:United States; D014611:Vaccination / Q000009:adverse effects*; D014612:Vaccines / Q000009:adverse effects*; D055815:Young Adult
D014612:Vaccines