Association of interleukin-10-1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population.
We investigate whether interleukin-10 (IL-10)-1082 G/G genotype is associated with the mortality rate of acute respiratory distress syndrome (ARDS) in a hospital-based case-control study in China conducted on 314 patients with ARDS and 210 controls admitted to an intensive care unit for sepsis, trauma, aspiration, or massive transfusions. IL-10-1082 promoter polymorphisms were analyzed with polymerase chain reaction amplification followed by restriction fragment length polymorphism. Mortality was recorded if it occurred within 30 days from admission. The -1082G/G genotype was associated with lower frequency of ARDS (odds ratios=0.51; 95% confidence intervals: 0.34-0.76; p=0.001), and in patients with ARDS, it was associated with lower mortality within 30 days (odds ratios=0.44; 95% confidence intervals: 0.25-0.76; p=0.003) than in controls. We conclude that IL-10-1082 G/G genotype is associated with a decreased rate development of ARDS and mortality in this Chinese population.
Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China. xdjin2010@hotmail.com
Xiaodong
X
Jin
Zhi
Z
Hu
Yan
Y
Kang
Chang
C
Liu
Yongfang
Y
Zhou
Xiaodong
X
Wu
Jin
J
Liu
Mingxing
M
Zhong
Chuanxing
C
Luo
Lijing
L
Deng
Yiyun
Y
Deng
Xiaoqi
X
Xie
Zhongwei
Z
Zhang
Yan
Y
Zhou
Xuelian
X
Liao
D018806:APACHE; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006785:Hospitals, University; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012128:Respiratory Distress Syndrome / Q000235:genetics* / Q000401:mortality*
D016753:Interleukin-10