E6 molecular variants of human papillomavirus (HPV) type 16: an updated and unified criterion for clustering and nomenclature.
Reports on taxonomic identification of E6/HPV 16 variants, don't have a worldwide, updated and unified criterion for clustering and nomenclature. Our aim was to update the existing criterion and propose a new one for clustering and nomenclature for E6/HPV 16 molecular variants based on the descriptive and comparative analyses of nucleotide sequences. A systematic search of the publications between 1991 and 2010 was carried out in PUBMED and manually. 240 E6/HPV 16 variants were identified. 157 were classified as European (E), 24 as Asian (As), 14 as Asian American (AA), 11 as North American 1 (NA 1), 19 as African 1 (Af 1) and 15 as African 2 (Af 2). Three classes were determined for the E, 3 each for the As, Af 2 and AA branches, 4 classes for the NA 1 and 6 for the Af 1 branch. This study reports our results and proposes an updated criterion for clustering and nomenclature that will be useful for E6 variant identification.
Grupo investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Calle 1 # 9 - 85, Bogotá D.C., Colombia.
Antonio
A
Huertas-Salgado
Diana C
DC
Martín-Gámez
Pablo
P
Moreno
Raúl
R
Murillo
María Mercedes
MM
Bravo
Luisa
L
Villa
Mónica
M
Molano
D001483:Base Sequence; D016000:Cluster Analysis; D005260:Female; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D014644:Genetic Variation; D014943:Global Health; D052162:Human papillomavirus 16 / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics* / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism*; D009626:Terminology as Topic; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology
C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins