Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels.
Cellular redox status, regulated by production of reactive oxygen species (ROS), greatly contributes to the regulation of vascular smooth muscle cell contraction, migration, proliferation, and apoptosis by modulating the function of transient receptor potential (TRP) channels in the plasma membrane. ROS functionally interact with the channel protein via oxidizing the redox-sensitive residues, whereas nitric oxide (NO) regulates TRP channel function by cyclic GMP/protein kinase G-dependent and -independent pathways. Based on the structural differences among different TRP isoforms, the effects of ROS and NO are also different. In addition to regulating TRP channels in the plasma membrane, ROS and NO also modulate Ca(2+) release channels (e.g., IP(3) and ryanodine receptors) on the sarcoplasmic/endoplasmic reticulum membrane. This review aims at briefly describing (a) the role of TRP channels in receptor-operated and store-operated Ca(2+) entry, and (b) the role of ROS and redox status in regulating the function and structure of TRP channels.
Biomedical Sciences Graduate Program, University of California-San Diego, La Jolla, CA, USA.
Michael Y
MY
Song
Ayako
A
Makino
Jason X-J
JX
Yuan
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000502:physiology*; D019255:NADPH Oxidases / Q000737:chemistry / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D000071737:Stromal Interaction Molecule 1; D013879:Thioredoxins / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000737:chemistry / Q000378:metabolism*
D008565:Membrane Proteins; D009363:Neoplasm Proteins; D017382:Reactive Oxygen Species; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1; D050051:Transient Receptor Potential Channels; D009569:Nitric Oxide; D013879:Thioredoxins; D019255:NADPH Oxidases; D017869:Cyclic GMP-Dependent Protein Kinases; D005978:Glutathione; D006152:Cyclic GMP; D002118:Calcium