A low ratio of high molecular weight adiponectin to total adiponectin associates with periodontal status in middle-aged men.
BACKGROUND
Periodontitis has been reported to relate closely to systemic diseases. However, a biomarker for periodontal status has not been established.


METHODS
A cross-sectional study was conducted using oral and systemic health checkup data of 151 middle-aged men. The serum levels of adiponectin and its subfractions were also analysed.


RESULTS
The ratio of high molecular weight adiponectin to total adiponectin was significantly lower in subjects with periodontal pockets. Moreover, this ratio independently associated with periodontal condition.


CONCLUSIONS
The ratio of HMW adiponectin to total adiponectin could be a novel biomarker for evaluation of periodontal health in middle-aged men.
Department of Internal Medicine, Osaka Dental University, Hirakata, Japan. nagano@cc.osaka-dent.ac.jp
Yutaka
Y
Nagano
Kumiko
K
Arishiro
Masako
M
Uene
Tatsuro
T
Miyake
Masaki
M
Kambara
Yasuhiro
Y
Notohara
Masanori
M
Shiraishi
Masatoshi
M
Ueda
Naochika
N
Domae
D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010514:Periodontal Pocket / Q000097:blood* / Q000503:physiopathology; D010518:Periodontitis / Q000097:blood* / Q000503:physiopathology; D012307:Risk Factors; D012907:Smoking
D052242:Adiponectin; D015415:Biomarkers