Comparison of interleukin-6 removal properties among hemofilters consisting of varying membrane materials and surface areas: an in vitro study.
OBJECTIVE
We sought to identify the most relevant hemofilter for cytokine removal based on the mechanisms of filtration and adsorption.


METHODS
Ascites were filtered using four types of hemofilters composed of different membrane materials (polymethyl methacrylate, PMMA, cellulose triacetate, CTA, or polysulfone, PS) and different surface areas (1.0 or 2.1 m(2)) to investigate the rate of interleukin-6 (IL-6) filtration. Next, ascites were perfused through each hemofilter without obtaining a filtrate to study each filter's adsorptive capability.


RESULTS
The PMMA hemofilters resulted in a marginal observed IL-6 filtration rates, whereas the CTA and PS hemofilters resulted in highly effective IL-6 filtration. Regarding the IL-6 adsorptive capabilities of the filters, the PMMA hemofilter with a large surface area showed the highest level of IL-6 clearance.


CONCLUSIONS
The present findings suggest that when cytokine removal based on filtration is desired, CTA or PS hemofilters should be selected. When IL-6 removal based on adsorption is desired, a PMMA hemofilter with a large surface area should be selected.
Departments of Emergency and Critical Care Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan. yoh2405@gmail.com
Yo
Y
Hirayama
Shigeto
S
Oda
Kiyohito
K
Wakabayashi
Tomohito
T
Sadahiro
Masataka
M
Nakamura
Eizo
E
Watanabe
Yoshihisa
Y
Tateishi
D000327:Adsorption; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004867:Equipment Design; D006440:Hemofiltration / Q000295:instrumentation*; D006801:Humans; D015850:Interleukin-6 / Q000302:isolation & purification*; D007700:Kinetics; D008567:Membranes, Artificial; D011108:Polymers / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry
D015850:Interleukin-6; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D002482:Cellulose; D019904:Polymethyl Methacrylate; C024671:cellulose triacetate