Novel Technology to study co-evolution of humans and Staphylococcus aureus: consequences for interpreting the biology of colonisation and infection.
Human nasal carriage of Staphylococcus aureus is a textbook example of an apparently neutral interaction between humans and a bacterial species that can still lead to (severe) opportunistic infections. The co-evolutionary aspects of this interaction are slowly surfacing, facilitated by the emergence of a diversity of diagnostic, epidemiological and molecular research tools. Basic microbiology has helped define persistent vs. non-carriage and the genotype of both host and guest has been explored in search of genetic markers for bacterial persistence. This chapter summarises the current state of affairs relating to artificial human colonisation studies with S. aureus, large-scale human cohort studies and innovative assessment of the humoral immune status of (non-)nasal carriers. These experimental approaches have recently assisted in identifying bacterial and human determinants and risk factors for staphylococcal carriage. Further refinement of the model by describing the interactions between S. aureus and its human host in molecular detail is important since it may pinpoint novel anti-infectious strategies.
BioMérieux, La Balme les Grottes, France. alex.vanbelkum@biomerieux.com
Alex
A
van Belkum
D000907:Antibodies, Bacterial / Q000276:immunology; D019143:Evolution, Molecular; D023281:Genomics / Q000639:trends*; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D008829:Microbiology / Q000639:trends*; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000276:immunology / Q000635:transmission; D013211:Staphylococcus aureus / Q000235:genetics / Q000254:growth & development / Q000276:immunology
D000907:Antibodies, Bacterial