Can increased muscle ROS scavenging keep older animals young and metabolically fit?
Insulin resistance and lipid accumulation occur with aging, perhaps due to mitochondrial dysfunction. In this issue of Cell Metabolism (Lee et al., 2010), older mice overexpressing mitochondrial targeted catalase had reduced muscle mitochondrial oxidative damage, lower intramuscular lipid, and improved insulin sensitivity, suggesting that enhanced ROS scavenging prevents age-associated mitochondrial impairments and insulin resistance.
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Darcy L
DL
Johannsen
Eric
E
Ravussin