Morphofunctional evaluation of the effect of collagen-1-based dressing on skin regeneration after burn trauma in mice of two genetic strains.
Morphofunctional evaluation of the effect of biological dressing with collagen-1 on healing of 3A degree burn wound in outbred and mutant Hr(hr)/Hr(hr)(hairless) mice was carried out by the histological method and optic radioautography. A pronounced stimulatory effect of the dressing on skin regeneration in mice was demonstrated. According to radioautography data, early dressing of the burn wounds in Hr(hr)/Hr(hr)mice led to active proliferation of epithelial cells in dermal cyst and vascular endotheliocytes. The possible mechanisms of the stimulatory effect of collagen-based dressing on wound healing are discussed.
N. V. Sklifosovsky Institute of Urgent Care, Moscow, Russia. kolokol_eg@mail.ru
E G
EG
Kolokolchikova
E A
EA
Zhirkova
P K
PK
Golovatenko-Abramov
E S
ES
Platonov
V S
VS
Botcharova
V B
VB
Khvatov
D000818:Animals; D001345:Autoradiography; D001684:Biological Dressings; D002056:Burns / Q000628:therapy*; D049109:Cell Proliferation; D024042:Collagen Type I / Q000627:therapeutic use*; D004847:Epithelial Cells / Q000166:cytology; D051379:Mice; D008812:Mice, Hairless; D012038:Regeneration / Q000502:physiology*; D012879:Skin Physiological Phenomena; D014945:Wound Healing / Q000187:drug effects*
D024042:Collagen Type I