Highly chemoselective nickel-catalyzed three-component cross-trimerization between two distinct terminal alkynes and an internal alkyne.
The highly chemo-, regio-, and stereoselective three-component cross-trimerization reaction between triisopropylsilylacetylene, diarylacetylene, and a terminal alkyne was achieved by Ni(cod)(2)/P(p-CF(3)C(6)H(4))(3) catalyst at room temperature via selective C-H oxidative addition of the terminal silylacetylene. The reaction is applicable for various diarylacetylenes and terminal alkynes to yield the corresponding 1,3-diene-5-yne compounds.
Department of Applied Chemistry, Institute of Science and Enginnering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. kogata@kc.chuo-u.ac.jp
Kenichi
K
Ogata
Yuka
Y
Atsuumi
Shin-Ichi
S
Fukuzawa