Procalcitonin as an early indicator of outcome in sepsis: a prospective observational study.
This study explores the role of procalcitonin (PCT) in predicting the outcome of sepsis. In a prospective multicentre observational investigation, blood was sampled within 24 h of onset of sepsis in 1156 hospitalised patients; 234 were in the intensive care unit (ICU) at the point of presentation of sepsis while 922 were not. PCT was estimated in serum by the ultrasensitive Kryptor assay in a double-blinded fashion. Among patients outside the ICU, mortality was 8% in those with PCT ≤0.12 ng/mL but 19.9% in those with PCT >0.12 ng/mL [P<0.0001, odds ratio (OR) for death: 2.606; 95% confidence interval (CI): 1.553-4.371]. Among patients whose sepsis presented in ICU, mortality was 25.6% in those with PCT ≤0.85 ng/mL but 45.3% in those with PCT >0.85 ng/mL (P=0.002; OR for death: 2.404; 95% CI: 1.385-4.171). It is concluded that PCT cut-off concentrations can contribute to predicting the outcome of sepsis and might be of particular value in identifying patients who would benefit from ICU admission.
4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece. giamarel@ath.forthnet.gr
E J
EJ
Giamarellos-Bourboulis
I
I
Tsangaris
Th
T
Kanni
M
M
Mouktaroudi
I
I
Pantelidou
G
G
Adamis
S
S
Atmatzidis
M
M
Chrisofos
V
V
Evangelopoulou
F
F
Frantzeskaki
P
P
Giannopoulos
G
G
Giannikopoulos
D
D
Gialvalis
G M
GM
Gourgoulis
K
K
Kotzampassi
K
K
Katsifa
G
G
Kofinas
F
F
Kontopidou
G
G
Koratzanis
V
V
Koulouras
A
A
Koutsikou
M
M
Koupetori
I
I
Kritselis
L
L
Leonidou
A
A
Mega
V
V
Mylona
H
H
Nikolaou
S
S
Orfanos
P
P
Panagopoulos
E
E
Paramythiotou
A
A
Papadopoulos
X
X
Papanikolaou
M
M
Pavlaki
V
V
Polychronopoulos
A
A
Skoutelis
A
A
Theodotou
M
M
Vassiliaghou
E E
EE
Douzinas
C
C
Gogos
A
A
Armaganidis
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D019411:Clinical Laboratory Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D018805:Sepsis / Q000175:diagnosis* / Q000401:mortality*; D016896:Treatment Outcome
C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide