[When is thyroid fine-needle biopsy most effective?].
The essentially desirable standardisation of various European and American guidelines for the evaluation of thyroid nodules has led to the recommendation to perform fine-needle biopsy (FNB) in all nodules >1 cm in order to detect clinically occult thyroid carcinoma early. However, in iodine-deficient areas such as Germany (where thyroid nodules are found in approximately 25% of the adult population) this recommendation would substantially increase both the number of FNB and thyroid operations without significantly increasing the cancer detection rate. The recommendation for FNB in Germany, therefore, should be restricted to hypofunctioning ("cold") nodules >1 cm.
Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Deutschland. kw.schmid@uk-essen.de
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D000328:Adult; D000465:Algorithms; D044963:Biopsy, Fine-Needle; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D005858:Germany; D006043:Goiter, Endemic / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D007455:Iodine / Q000172:deficiency; D017410:Practice Guidelines as Topic; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D016606:Thyroid Nodule / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*
D007455:Iodine