[Common pathogenetic features between calcific aortic stenosis and atherosclerosis: role of receptor for advanced glycation end-products].
Clinical and experimental studies identified several similarities between calcific aortic stenosis and atherosclerosis, suggesting the involvement of similar pathogenic pathways in both conditions.There are several molecules involved in regulating the development, progression and calcification of the valve sclerosis and in growth and complications of atherosclerotic plaque. Among these molecules, the receptor of advanced glycation end-products, a multi-ligand receptor involved in the pathogenesis of several degenerative, inflammatory and immune diseases, could have an important regulatory role in both diseases and therefore worthy of study as a potential target therapeutic for both conditions.
Dipartimento Cardio-Toracico eVascolare, Università, Pisa.
Anca Irina
AI
Corciu
Serena
S
Del Turco
Rosa
R
Sicari
Giuseppina
G
Basta
D001024:Aortic Valve Stenosis / Q000209:etiology*; D050197:Atherosclerosis / Q000209:etiology*; D002114:Calcinosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology*
D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic