A study of DNA damage recognition and repair gene polymorphisms in relation to cancer predisposition and G2 chromosomal radiosensitivity.
The previously reported association of the APEX Asp148Glu single nucleotide polymorphism (SNP) with cancer, and the suggestion of associations of the XRCC3 Thr241Met and hOGG1 Ser326Cys SNP sites with G(2) chromosomal radiosensitivity were investigated in a new study of 30 childhood and young adult cancer survivors, their 30 partners, and 55 offspring. An additional SNP, hOGG1 Arg46Gln was also analyzed. Data on G(2) chromosomal radiosensitivity was available on 29 of the families including 53 offspring. No significant associations of genotype with cancer or G(2) chromosomal radiosensitivity were observed.
Westlakes Research Institute, Westlakes Science and Technology Park, Moor Row, Cumbria, CA24 3LN, United Kingdom. gillian.curwen@gmail.com
Gillian B
GB
Curwen
Samantha
S
Murphy
Elizabeth J
EJ
Tawn
Jeanette F
JF
Winther
John D
JD
Boice
D002869:Chromosome Aberrations / Q000528:radiation effects; D004249:DNA Damage / Q000235:genetics* / Q000528:radiation effects*; D045647:DNA Glycosylases / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014965:X-Rays / Q000009:adverse effects
D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human