Rhabdomyolysis induced by co-administration of fluvastatin and colchicine.
A case of fluvastatin-induced rhabdomyolysis after coadministration of colchicine is reported. A 77 year old man with ischemic heart disease, chronic pericardial effusion, diabetes mellitus, dyslipidemia, arterial hypertension, chronic renal failure (stage 2 of classification of chronic kidney disease of National Kidney Foundation) and chronic gout presented with a generalized muscle pain. The patient had been taking 80 mg/day of fluvastatin for 4 years, and, for four weeks before presentation, he had also been taking a dose of colchicine (1.0 mg daily) for an exacerbation of gout. Investigations confirmed the diagnosis of rhabdomyolysis. Discontinuation of fluvastatin and colchicine therapy and adequate fluid administration resulted in the resolution of clinical and biochemical features of rhabdomyolysis. Although neuromuscular adverse effects of fluvastatin and colchicine are well recognized, rhabdomyolysis is rare, making this is only the second case reported of fluvastatin and colchicine co-administration induced rhabdomyolysis in literature.
Division of Cardiology, Buccheri La Ferla-Fatebenefratelli Hospital, Palermo, Italy. fsarullo@neomedia.it
Filippo M
FM
Sarullo
Luigi
L
Americo
Antonino
A
Di Franco
Pietro
P
Di Pasquale
D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D003078:Colchicine / Q000009:adverse effects*; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects*; D000077340:Fluvastatin; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced*
D000924:Anticholesteremic Agents; D005229:Fatty Acids, Monounsaturated; D006074:Gout Suppressants; D007211:Indoles; D000077340:Fluvastatin; D003078:Colchicine