Iatrogenic oral hairy leukoplakia: report of two cases.
Oral hairy leukoplakia (OHL) presents as a white, plaque-like lesion typically occurring on the lateral border of the tongue. This condition is caused by the Epstein-Barr virus, a human herpesvirus that often establishes lifelong, asymptomatic latent infection. OHL, initially described in immunocompromised men infected with the human immunodeficiency virus (HIV), has also been described in other severely immunocompromised patients. Only rarely has OHL been reported in less profoundly immunocompromised patients primarily in the setting of corticosteroid therapy. Here we report on two additional cases of OHL attributable to immunosuppressive medications.
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.
Erica C
EC
Rushing
Aaron P
AP
Hoschar
Jonnelle K
JK
McDonnell
Steven D
SD
Billings
D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D002990:Clobetasol / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D017733:Leukoplakia, Hairy / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D008010:Lichen Planus / Q000150:complications / Q000188:drug therapy; D008727:Methotrexate / Q000494:pharmacology; D009761:Nystatin / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D015034:Zinc Oxide / Q000627:therapeutic use
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D003879:Dermatologic Agents; D009761:Nystatin; D003907:Dexamethasone; D015725:Fluconazole; D003622:Dapsone; D002990:Clobetasol; D015034:Zinc Oxide; D011241:Prednisone; D008727:Methotrexate