[Protected effects of MG-132 on apoptosis induced by deltamethrin in rat's hippocampus].
OBJECTIVE
To study the protective effect of MG-132 on hippocampus cells apoptosis induced by deltamethrin (DM), one kind of pyrethroid pesticide.


METHODS
40 Male wistar rats were randomly divided into four groups: olive oil control, DM treated alone (12.5 mg/kg), MG-132 (0.5 mg/kg) plus DM group, MG-132 treated 2h plus olive oil. After 24h treatment of DM, the hippocampus was taken out to detect the apoptotic cell rate, the level of bcl-2 and Caspase-3 activity.


RESULTS
Compared with DM treated alone group (27.29% +/- 2.41%), the apoptotic cell rate in MG-132 + DM group (19.94% +/- 2.07%) was increased (P < 0.05), bcl-2 expression was enhanced [(0.43 +/- 0.06) vs. (2.01 +/- 0.23)] (P < 0.05) and the activity of Caspase-3 was decreased significantly (P < 0.05) in MG-132 treated 2h plus DM group [(4.55 +/- 0.46) vs.(3.73 +/- 0.35)].


CONCLUSIONS
MG-132 can protect hippocampus cells against apoptosis induced by deltamethrin.
Department of Health Toxicology,School of Public Health, Tonji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xiao-Wei
XW
Huang
Yan
Y
Qing
Yan-fang
YF
Liang
Nian
N
Shi
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity; D007976:Leupeptins / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D009570:Nitriles / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D007306:Insecticides; D007976:Leupeptins; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; C072553:benzyloxycarbonylleucyl-leucyl-leucine aldehyde