Craniofacial characteristics in cri-du-chat syndrome.
OBJECTIVE
The purpose of this study was to analyze craniofacial characteristics from lateral head profile radiographs of patients with cri-du-chat (CdC) syndrome.


METHODS
The craniofacial morphology of 10 CdC patients was evaluated using standard cephalometric methods, measuring 39 craniofacial variables on cephalometric x-ray images.


RESULTS
The principal characteristics were skeletal class II malocclusion, caused by mandibular retrognathism, dental biprotrusion, and a small upper airway. Additionally, 70% of patients had a steep palatal plane angle; the cranial base angle was flattened, also in 70% of patients.


CONCLUSIONS
Results indicated that the deletion of 5p had an impact on the cranial base, maxilla, mandible, and upper airway, causing distinctive features to become apparent through irregular growth.
Master's Program in Orthodontics and Dentofacial Orthopedics, School of Dentistry, University of Seville, Seville, Spain.
Rosa-María
RM
Yáñez-Vico
Angela
A
Rodríguez-Caballero
Alejandro
A
Iglesias-Linares
Noelia
N
Guerra-López
Daniel
D
Torres-Lagares
Guillermo
G
Machuca-Portillo
Enrique
E
Solano-Reina
José-Luis
JL
Gutiérrez-Pérez
D002508:Cephalometry / Q000379:methods*; D002680:Chin / Q000473:pathology; D019465:Craniofacial Abnormalities / Q000175:diagnosis*; D003410:Cri-du-Chat Syndrome / Q000150:complications*; D004955:Esthetics, Dental; D005260:Female; D006801:Humans; D008297:Male; D008312:Malocclusion, Angle Class II / Q000175:diagnosis; D008334:Mandible / Q000002:abnormalities; D008437:Maxilla / Q000002:abnormalities; D008445:Maxillofacial Development / Q000502:physiology; D009295:Nasal Bone / Q000473:pathology; D010159:Palate / Q000002:abnormalities; D010614:Pharynx / Q000002:abnormalities; D010781:Photography; D019252:Radiography, Dental, Digital; D063173:Retrognathia / Q000175:diagnosis; D019291:Skull Base / Q000473:pathology; D014716:Vertical Dimension; D055815:Young Adult