Does a positive pretransplant crossmatch affect long-term outcome in liver transplantation?
Despite the historical success of liver transplantation in the face of a positive lymphocytic crossmatch, increased incidence of acute cellular rejection and graft loss have been reported in this setting. Given the potential adverse effects of antirejection treatment, especially in hepatitis C virus-positive recipients, identification of predisposing factors could allow for better surveillance, avoidance of rejection, and potentially better graft outcomes.
Division of Transplant and Hepatobiliary Surgery, William Beaumont Hospital/Oakland University Medical School, Royal Oak, MI 48073, USA.
Mohamad R
MR
Al-Sibae
Alan J
AJ
Koffron
Vandad
V
Raofi
D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006526:Hepatitis C / Q000601:surgery*; D006650:Histocompatibility Testing; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D016896:Treatment Outcome