[The effect of selected hydrophilisers on metronidazole release from hydrogels stomatological dressings on the basis of Carbopol 971].
The aim of this study was to assess the influence of qualitative and quantitative base composition on pharmaceutical availability of metronidazole. Hydrogels contain water dispersion of 2% Carbopol 971P and various concentration of glycerol, polyethylene glycol and propylene glycol were preparated. Produced formulations were neutralized to the pH 6.0-6.5 with triethanolamine, and metronidazole in concentration 1% added. The test for pharmaceutical bioavailability was performed in vitro, the rate of diffusing therapeutic agent through a semipermable into acceptor fluid was tested. The quantity of metronidazole released at the same time intervals was tested by spectrophotometric method. Hydrogel consists of 99% water dispersion of Carbopol 971P and 1% glycerol characterized by the largest pharmaceutical bioavailability.
Katedra Technologii Postaci Leku, Akademia Medyczna we Wrocławiu. dorkid@wp.pl
Dorota
D
Kida
Janusz
J
Pluta
D000180:Acrylic Resins; D001458:Bandages; D001682:Biological Availability; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D004983:Ethanolamines / Q000032:analysis / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008795:Metronidazole / Q000032:analysis / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D012212:Rheology; D013053:Spectrophotometry; D054047:Surgical Stomas
D000180:Acrylic Resins; D004337:Drug Carriers; D004983:Ethanolamines; D020100:Hydrogels; D011145:Polyvinyls; C006912:carboxypolymethylene; D008795:Metronidazole; C009546:triethanolamine