The effect of caffeine consumption on the success rate of pregnancy as well various performance parameters of in-vitro fertilization treatment.
BACKGROUND
This study evaluated the effect of caffeine consumption on the success rate of pregnancy and various in vitro fertilization (IVF) performance parameters.


METHODS
Serum and follicular fluid samples were collected from 619 women undergoing IVF treatment (2002-2003). Caffeine assessment was based on measuring the levels of caffeine in serum and follicular fluid and on the number of coffee or tea or caffeinated drinks consumed per day.


RESULTS
A total of 97.3% of participants reported the consumption of caffeinated drinks such as coffee, tea and soft drinks. Their average caffeine consumption was 455.82 mg/day (range: 3.71-3561 mg/day). Coffee was the primary source of caffeine intake. The average caffeine levels in serum (0.913 µg/ml) were significantly higher than in follicular fluid (0.701 µg/ml). After controlling for various potential confounding variables, no association was found between coffee or tea consumption and the success rate of pregnancy. Looking at the effect of caffeine consumption on the IVF performance parameters, we found that the number of eggs decreased as the caffeine serum levels increased (P=0.011). An increase in coffee consumption was positively associated with the number of aborted pregnancy (P=0.007), while the number of good embryo decreased with high tea consumption (P=0.015).


CONCLUSIONS
Though no association was seen between coffee or tea consumption and pregnancy rate, this study is the first to report that caffeine can reach the follicular fluid and there is a suggestive evidence of its possible harmful role on the consequences of reproductive process. This clearly warrants further investigation.
Environmental Health Section, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. iman@kfshrc.edu.sa
Iman
I
Al-Saleh
Inaam
I
El-Doush
Bellido
B
Grisellhi
Serdar
S
Coskun
D000022:Abortion, Spontaneous / Q000139:chemically induced; D002110:Caffeine / Q000032:analysis / Q000097:blood / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000032:analysis / Q000097:blood / Q000494:pharmacology*; D003069:Coffee; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D015571:Follicular Fluid / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D016017:Odds Ratio; D011247:Pregnancy; D011256:Pregnancy Outcome; D012044:Regression Analysis; D012529:Saudi Arabia; D013662:Tea
D000697:Central Nervous System Stimulants; D003069:Coffee; D013662:Tea; D002110:Caffeine