Primary cytomegalovirus infectious colitis complicating Crohn's disease successfully treated with oral valganciclovir.
Most cases of cytomegalovirus (CMV) colitis that develop in patients with inflammatory bowel disease (IBD) are caused by reactivation of a latent virus. Primary CMV infections are rare in adult patients. Treatment with immunosuppressive agents increases the infection risk in patients with IBD. We present a 26 year old lady with primary CMV colitis, superimposed on underlying Crohn's colitis. The diagnosis was confirmed by a viral-like prodrome, a positive CMV IgM titer, presence of low avidity IgG antibodies to CMV, high CMV DNA titers in the plasma, and immunohistological detection of CMV positive cells in her colonic mucosa. The patient responded to initial treatment with intravenous ganciclovir with a fall in plasma levels of CMV DNA, treatment was completed with oral valganciclovir until plasma CMV DNA levels became undetectable.
Department of Gastroenterology, St George's Healthcare NHS Trust, Blackshaw Road, London SW17 0QT, United Kingdom. venkat@nottingham.ac.uk
Venkataraman
V
Subramanian
Caroline
C
Finlayson
Thomas
T
Harrison
Phillip
P
Rice
Richard
R
Pollok
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003092:Colitis / Q000821:virology*; D003424:Crohn Disease / Q000150:complications* / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015774:Ganciclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects; D009894:Opportunistic Infections / Q000150:complications*; D016896:Treatment Outcome; D000077562:Valganciclovir; D019562:Viral Load
D000998:Antiviral Agents; D004279:DNA, Viral; D007166:Immunosuppressive Agents; D000077562:Valganciclovir; D015774:Ganciclovir