[Control of bone remodeling by nervous system. Regulation of bone metabolism by peripheral nervous system].
Bone is richly innervated with adrenergic and peptidergic nerve terminals, and these play important roles in bone remodeling. Recent study confirmed a functional nerve-osteoblastic interplay by using an in vitro co-culture model comprising mouse osteoblastic cells and neurite-spouting mouse superior cervical ganglia. This indicates that nerve-osteoblastic cell cross-talk can occur for the dynamic regulation of local bone metabolism by peripheral nervous system. This review summarized both in vivo and in vitro evidences implicating peripheral neuron action in bone metabolism.
Department of Pharmacology, School of Dentistry, Aichi-Gakuin University, Aichi-Gakuin, Japan.
Akifumi
A
Togari
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000294:innervation / Q000378:metabolism*; D006801:Humans; D051379:Mice; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D017933:Peripheral Nervous System / Q000502:physiology*; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology; D017783:Superior Cervical Ganglion / Q000502:physiology; D013569:Synapses
D018377:Neurotransmitter Agents; D018343:Receptors, Adrenergic, beta-2; D009638:Norepinephrine