A practical and green approach toward synthesis of 2,4,5-trisubstituted imidazoles without adding catalyst.
A simple, efficient, and inexpensive procedure has been developed for the synthesis of 2,4,5-triaryl imidazoles by a three-component, one-pot condensation of benzyl, aldehydes, and ammonium acetate in refluxing ethanol without adding catalyst. The "catalyzed-by-itself" approach shows a new direction in green synthesis of the title products.
College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, Liaoning, P.R. China. minwangszg@yahoo.com.cn
Min
M
Wang
Jingjing
J
Gao
Zhiguo
Z
Song
D000085:Acetates / Q000138:chemical synthesis / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D055772:Green Chemistry Technology / Q000191:economics / Q000379:methods*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D000085:Acetates; D000447:Aldehydes; D007093:Imidazoles; C018824:ammonium acetate