Osteogenic sarcoma of the maxillary region in a Mexican mestizo population.
OBJECTIVE
This study analyzed maxillary osteosarcoma in a mestizo population, with particular emphasis on the type of treatment and disease-free and overall survival.


METHODS
This is a retrospective study including all mestizo patients with osteosarcoma of the maxilla seen in a single cancer institution in Mexico during a 20-year period.


RESULTS
There were 21 patients. Age ranged from 16 to 76 years (mean, 37.5 y). Mean evolution time to diagnosis was 13 months, with a mean tumor size of 7 × 6 cm2. Surgery was the initial treatment in 19 patients, 17 of whom received adjuvant treatment. Disease-free survival according to surgical margin and overall survival were not statistically significant. Disease-free survival was 29% at 5 years, and overall survival was 50% and 25% at 5 and 10 years, respectively.


CONCLUSIONS
Osteosarcomas of the maxilla are infrequent lesions that merit early diagnosis and proper treatment because of their rapid evolution. Treatment is currently based on a well-planned surgery with free surgical margins plus adjuvant radiotherapy and/or chemotherapy.
Department of Head and Neck Surgery, Instituto Nacional de Cancerología, Mexico City, Mexico. kuauhyama@starmedia.com
Kuauhyama
K
Luna-Ortiz
Veronica
V
Villavicencio-Valencia
Tania
T
Carmona-Luna
Philippe
P
Pasche
Adalberto
A
Mosqueda-Taylor
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D017024:Chemotherapy, Adjuvant / Q000706:statistics & numerical data; D018572:Disease-Free Survival; D005006:Ethnicity / Q000706:statistics & numerical data*; D005500:Follow-Up Studies; D006801:Humans; D008441:Maxillary Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000601:surgery; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000706:statistics & numerical data; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012516:Osteosarcoma / Q000453:epidemiology* / Q000208:ethnology / Q000601:surgery; D010027:Osteotomy / Q000706:statistics & numerical data; D018714:Radiotherapy, Adjuvant / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult