Stereoselective palladium-catalyzed allylic alkylations of peptide amide enolates.
Pd-catalyzed allylations are an excellent tool for stereoselective peptide modifications, being clearly superior to normal alkylations. The reactions proceed not only in high yield, but also high regio- and diastereoselectivities, and trans-products are formed exclusively. Therefore, this is a powerful synthetic tool for natural product and drug synthesis.
Institut für Organische Chemie, Universität des Saarlandes, D-66123, Saarbrücken, Germany.
Swarup
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Datta
Uli
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Kazmaier
D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism
D000498:Allyl Compounds; D000577:Amides; D010455:Peptides; D010165:Palladium