[Role of pro-oxidant properties of flavonoids in the induction of detoxifying enzymes gene expression].
Flavonoids are one of the most important components of human daily diet. In recent years flavonoids have became the subject of extensive investigations mostly due to their heath-promoting properties. Beneficial health effects of flavonoids are mainly ascribed to their antioxidant activity. However, there is increasing evidence of the positive role of pro-oxidant properties of flavonoids, considered previously as highly unfavorable, through the induction of detoxifying enzymes gene expression. The article discusses recent reports on the EpRE-mediated induction of NQO1 (NAD(P)H: quinone oxidoreductase) gene expression by the flavonoids (flavonols, flavones and flavan-3-oles) and the role of pro-oxidant properties of the flavonoids in the mechanism of this induction.
Department of Food Quality Management, Faculty of Food Science and Nutrition, Poznan University of Life Science, 31 Wojska Polskiego St., 60-624 Poznan, Poland.
Małgorzata
M
Muzolf-Panek
Bozena
B
Tyrakowska
D005419:Flavonoids / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000494:pharmacology*
D005419:Flavonoids; D017382:Reactive Oxygen Species; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human