Effects of combination therapy with warfarin and bucolome for anticoagulation in patients with atrial fibrillation.
BACKGROUND
Bucolome, a nonsteroidal antiinflammatory drug, enhances the effects of warfarin. In the present study, the effects of combination therapy (bucolome+warfarin) vs. warfarin alone on atrial fibrillation were investigated.


RESULTS
Combined therapy resulted in a decrease in the warfarin dose to approximately one-third. The fluctuations of the international normalized ratio and the time in therapeutic range were similar in both groups. There was no adverse effect in either group. Interestingly, uric acid was lower in the bucolome group.


CONCLUSIONS
Bucolome enhanced the effects of warfarin, resulting in a decreased dose of warfarin without adverse effects and it showed similar anticoagulant stability to warfarin alone.
Division of Cardiology, Niigata University School of Medical and Dental Sciences, Niigata, Japan. h-oba@qc4.so-net.ne.jp
Hiroaki
H
Obata
Hiroshi
H
Watanabe
Masahiro
M
Ito
Satoru
S
Hirono
Haruo
H
Hanawa
Makoto
M
Kodama
Yoshifusa
Y
Aizawa
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000925:Anticoagulants / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D001463:Barbiturates / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D007564:Japan; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D001463:Barbiturates; D014859:Warfarin; C084817:bucolome