Personality changes after Toscana virus (TOSV) encephalitis in a 49-year-old man: A case report.
Toscana virus (TOSV) infection may often cause symptomatic meningitides and encephalitides. These usually subside in few days and their sequelae do not last for more than few weeks. We here report the case of a 49-year-old man who developed encephalitis after being bitten by phlebotomi in a region near southern Tuscany, where TOSV is endemic, and who developed postencephalitic seizures and subsequently, persistent personality alterations, characterized by sexually dissolute behavior and aggressiveness. One year after infection, the patient needs a combination of an SSRI antidepressant and a mood stabilizer/anticonvulsant to obtain less than optimal symptom improvement. This points to the need of establishing better preventive measures in Tuscany and nearby regions.
Department of Neuropsychiatry, Villa Rosa, Suore Hospitaliere of the Sacred Heart of Jesus, Viterbo, Italy. seratadaniele@gmail.com
Daniele
D
Serata
Chiara
C
Rapinesi
Antonio
A
Del Casale
Alessio
A
Simonetti
Lorenzo
L
Mazzarini
Elisa
E
Ambrosi
Giorgio D
GD
Kotzalidis
Claudio
C
Fensore
Paolo
P
Girardi
Roberto
R
Tatarelli
D000374:Aggression; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002044:Bunyaviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000523:psychology* / Q000821:virology; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology / Q000523:psychology / Q000821:virology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology / Q000821:virology; D018792:Encephalitis, Viral / Q000473:pathology / Q000523:psychology* / Q000821:virology; D019353:Endemic Diseases; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D005911:Gliosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008582:Meningitis, Aseptic / Q000473:pathology / Q000523:psychology* / Q000821:virology; D008875:Middle Aged; D016273:Occupational Exposure; D010551:Personality; D015995:Prevalence; D029301:Sandfly fever Naples virus / Q000276:immunology / Q000302:isolation & purification*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012725:Sexual Behavior
D000914:Antibodies, Viral; D000927:Anticonvulsants; D018692:Antimanic Agents; D017367:Selective Serotonin Reuptake Inhibitors