Serum concentration of interleukin 15, interleukin 2 receptor and TNF receptor in patients with polymyositis and dermatomyositis: correlation to disease activity.
Cytokines are implied in polymyositis/dermatomyositis (PM/DM) pathogenesis. Our aim was to evaluate the serum levels of interleukin-15 (IL-15), soluble receptors for IL-2 (sIL-2R) and TNF-alpha type 1 receptor (sTNF-R1) in PM/DM patients and their relation to disease activity and clinical symptoms. Thirty-eight patients who met definite or probable criteria of Bohan and Peter for DM/PM were included into the study. Results in patients with active (41 observations) and inactive disease (24 observations) were compared with control (15 subjects). The median level of IL-15 was 47.6 ± 170 pg/ml in active patients, 25.15 ± 240 pg/ml in inactive and 28.5 ± 28.89 pg/ml in controls. We demonstrated significant differences between active patients and controls in levels of IL-15 (0.016, 95%CI 1.39-57.1). The median level of sIL-2R was 314 ± 388, 235.3 ± 269 and 144.3 ± 152.9 pg/ml, and the median level of sTNF-R1 was 350 ± 388; 294.7 ± 204.7; 209.5 ± 105.9 pg/ml in active, inactive and control subjects, respectively. There were significantly higher serum levels of these cytokines in active patients than in control subjects (for sIL-2R P = 0.05, CI95% 0.4-331; and sTNF-R1 P = 0.031, CI95% 15.1-321.5). The interleukin levels did not differ between inactive patients and controls. Elevation of IL-15, sIL2-R and sTNF-R1 in active patients provides preliminary evidence for the activation of inflammatory response during PM/DM flares. Further studies may be needed to explain the mechanisms driving these diseases.
Department of Connective Tissue Diseases, Institute of Rheumatology, Spartanska 1, Warsaw, Poland. mielnik.p@gmail.com
Pawel
P
Mielnik
Hanna
H
Chwalinska-Sadowska
Ewa
E
Wiesik-Szewczyk
Wlodzimierz
W
Maslinski
Marzena
M
Olesinska
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003882:Dermatomyositis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D019409:Interleukin-15 / Q000097:blood*; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D012871:Skin Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis
D015415:Biomarkers; D019409:Interleukin-15; D015375:Receptors, Interleukin-2; D047888:Receptors, Tumor Necrosis Factor, Type I