Structure of nuclear chromatin in cells of lymphoid organs and blood from mice maintained under abnormal light-dark cycle and treated with benz(a)pyrene.
We studied the effects of benzo(a)pyrene on lymphocyte chromatin in mice with experimental desynchronosis. Desynchronosis altered chromatin structure in immune system cells and suppressed the immune response. In mice with experimental desynchronosis, benzo(a)pyrene produced more pronounced changes in the chromatin structure compared to the control. It was inferred that light-dark cycle disturbances impair the resistance of organs and systems to damaging environmental factors.
Institute of Clinical and Experimental Lymphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. anna_v_s@mail.ru
A V
AV
Shurlygina
S V
SV
Mitshurina
L V
LV
Verbitskaja
A D
AD
Belkin
T V
TV
Shanturova
M V
MV
Bitchaeva
I G
IG
Kovshik
V A
VA
Trufakin
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002843:Chromatin / Q000187:drug effects* / Q000648:ultrastructure; D002940:Circadian Rhythm / Q000276:immunology*; D007091:Image Processing, Computer-Assisted; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D051379:Mice; D008853:Microscopy; D017440:Photoperiod; D018709:Statistics, Nonparametric
D002843:Chromatin; D001564:Benzo(a)pyrene