New myrsinane-type diterpenoids from Euphorbia aellenii Rech. f. with their immunomodulatory activity.
Two new 14-desoxo-10, 18-dihydromyrinsol diterpenoids (1 and 2) were isolated and characterized from the cytotoxic chloroform fraction of Euphorbia aellenii Rech. f. (Euphorbiaceae). The structures of the new compounds were elucidated by spectroscopic methods and their immunomodulatory properties were evaluated by T-cell proliferation and phagocyte chemiluminescence assays.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abdul Majid
AM
Ayatollahi
Mustafa
M
Ghanadian
M Ahmed
MA
Mesaik
Omer
O
Mohamed Abdella
Suleiman
S
Afsharypuor
Farzad
F
Kobarfard
Marjan
M
Mirza-Taheri
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007492:Iran; D008163:Luminescent Measurements; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010586:Phagocytes / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects
C554710:14-desoxo-3alpha,5alpha,7beta,10,15beta-O-pentaacetyl-14beta-O-butanoyl-10,18-dihydromyrinsol; C554709:14-desoxo-3beta,5alpha,7beta,10,15beta-O-pentaacetyl-14alpha-O-benzoyl-10,18-dihydromyrinsol; D004224:Diterpenes; D007155:Immunologic Factors; D010835:Phytohemagglutinins; D017382:Reactive Oxygen Species