Recent advances in polyaniline based biosensors.
The present paper contains a detailed overview of recent advances relating to polyaniline (PANI) as a transducer material for biosensor applications. This conducting polymer provides enormous opportunities for binding biomolecules, tuning their bio-catalytic properties, rapid electron transfer and direct communication to produce a range of analytical signals and new analytical applications. Merging the specific nature of different biomolecules (enzymes, nucleic acids, antibodies, etc.) and the key properties of this modern conducting matrix, possible biosensor designs and their biosensing characteristics have been discussed. Efforts have been made to discuss and explore various characteristics of PANI responsible for direct electron transfer leading towards fabrication of mediator-less biosensors.
Department of Science and Technology Centre on Biomolecular Electronics, Biomedical Instrumentation Section, Materials Physics and Engineering Division, National Physical Laboratory, Council of Scientific and Industrial Research, Dr KS Krishnan Marg, New Delhi 110012, India.
Chetna
C
Dhand
Maumita
M
Das
Monika
M
Datta
B D
BD
Malhotra
D000814:Aniline Compounds / Q000737:chemistry; D055910:Antibodies, Immobilized; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D002784:Cholesterol / Q000032:analysis; D004247:DNA / Q000032:analysis / Q000235:genetics; D004553:Electric Conductivity; D055664:Electrochemical Techniques; D004579:Electron Transport; D004800:Enzymes, Immobilized; D005947:Glucose / Q000032:analysis; D006801:Humans; D009693:Nucleic Acid Hybridization; D010545:Peroxides / Q000032:analysis
D000814:Aniline Compounds; D055910:Antibodies, Immobilized; D004800:Enzymes, Immobilized; D010545:Peroxides; C416807:polyaniline; D004247:DNA; D002784:Cholesterol; D005947:Glucose