Potent transglutaminase inhibitors, dithio β-aminoethyl ketones.
Potent transglutaminase inhibitors were obtained from disulfide compounds, cystamine, dimethyl cystine, and dimethyl homocystine. The disulfide bond and thiophene ring play an important role in inhibitory activity of synthesized aryl β-amino ketones.
Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Shoichiro
S
Ozaki
Etsuko
E
Ebisui
Kozo
K
Hamada
Akinobu Z
AZ
Suzuki
Akiko
A
Terauchi
Katsuhiko
K
Mikoshiba
D004220:Disulfides / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry; D011503:Transglutaminases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004220:Disulfides; D004791:Enzyme Inhibitors; D007659:Ketones; D013876:Thiophenes; D011503:Transglutaminases