Cobalt reduces the Δ⁹-desaturase index of sow milk.
The main objective of this study was to examine if cobalt (Co) reduces Δ(9) -desaturase indices in milk and blood lipids in sows. The experimental design consisted of a repeated measurement consisting of a pre-treatment period of a minimum of 9 days, a treatment period of 5 days and a post-treatment period of 6 days. Experimental animals consisted of 10 lactating sows; five sows had an intramuscular injection of 59 mg Co diluted in 5 ml 0.9% saline solution twice a day, whereas the other five had an intramuscular injection of 5 ml 0.9% saline solution twice a day as a control. Milk Δ(9) -desaturase indices for cis-9 18:1, cis-9 16:1 and cis-9 14:1 were significantly reduced (p < 0.0001) as a result of the Co-treatment, contrasting with the plasma Δ(9) -desaturase indices, which were unaffected. Potential mechanisms explaining how Co might reduce milk Δ(9) -desaturase indices are discussed. Moreover, the toxicological level of Co and potential implications of using Co-ethylenediaminetetraacetic acid as a liquid marker in digestibility experiments are addressed.
Department of Animal and Aquacultural Sciences, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway. inger.johanne.karlengen@umb.no
I J
IJ
Karlengen
O M
OM
Harstad
N P
NP
Kjos
B
B
Salbu
A H
AH
Aastveit
O
O
Taugbøl
D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D004032:Diet / Q000662:veterinary; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D008892:Milk / Q000201:enzymology*; D013552:Swine / Q000097:blood / Q000378:metabolism*
D003035:Cobalt; D044943:Fatty Acid Desaturases