Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model.
BACKGROUND
C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction.


METHODS
We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction.


RESULTS
We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ~70% in the established treatment system.


CONCLUSIONS
We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14.
Emergency Medicine Unit, Department of Cardiology, Franz-Volhard-Klinik, Charité Berlin, Helios Clinic Berlin-Buch, Berlin, Germany.
Anna Christine
AC
Slagman
Christopher
C
Bock
Hassan
H
Abdel-Aty
Birgit
B
Vogt
Frank
F
Gebauer
Gunnar
G
Janelt
Franziska
F
Wohlgemuth
Rene
R
Morgenstern
Gülcan
G
Yapici
Astrid
A
Puppe
Diethelm
D
Modersohn
Dörte
D
Mans
Timo
T
Jerichow
Sascha
S
Ott
Rudolf
R
Kunze
Wieland
W
Schrödl
Christina
C
Janko
Martin
M
Hermann
Joachim R
JR
Kalden
Peter
P
Kern
Hans
H
Parsch
Michael
M
Kirschfink
Jeanette
J
Schulz-Menger
Rainer
R
Röttgen
Juliane K
JK
Unger
Ulrich
U
Frei
Ralf
R
Schindler
Martin
M
Möckel
Ahmed
A
Sheriff
D000818:Animals; D001781:Blood Component Removal / Q000379:methods*; D002097:C-Reactive Protein / Q000302:isolation & purification*; D005260:Female; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology / Q000628:therapy*; D013552:Swine
D002097:C-Reactive Protein