Radiation-induced chondrosarcomas: a case report with review of literature.
Radiation therapy has become an important component of various cancer treatments. The development of second malignancy as a result of radiation therapy is a well-known sinister complication. However, radiation-induced sarcomas (RIS) are rare complications of radiation therapy. The timescale between completion of the radiotherapy and the development of a second malignancy, known as the latent period, can vary widely from as little as 5 years to 50 years later. Radiation-induced sarcomas per se are very rare and those with histomorphology of chondrosarcomas are even rarer. We report a rare case of RIS of left iliac bone in a 62-year-old lady after combined chemotherapy and external beam radiation therapy for cervical carcinoma (stage IIb). This case is being reported for its extreme rarity, vivid histology and clinical presentation.
Department of Histopathology, Rajiv Gandhi Cancer Institute & Research Centre, Rohini, Delhi, India.
G
G
Gupta
A
A
Hafiz
J S
JS
Gandhi
D000230:Adenocarcinoma / Q000532:radiotherapy; D002813:Chondrosarcoma / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy