Synthesis and antihyperglycemic activity of phenolic C-glycosides.
Various phenolic C-glycosides were evaluated for their in vitro and in vivo antihyperglycemic activity employing glucose uptake by rat muscle cell lines (L-6) and low dosed-streptozotocin-induced diabetic rats, respectively. Some of phenolic C-glycosides were isolated from Pterocarpus marsupium and Ulmus wallichiana and other were synthesized by unprotected sugar and phloroacetophenone using Sc(OTf)(3) in aqueous ethanol. Eight among tested compounds showed significant lowering of blood glucose level on low dosed-streptozotocin-induced diabetic rats. The compound 24 lowered the blood glucose levels by 34.9% and 33.6% during 0-5h and 0-24h, respectively, at the dose of 25mg/kg body weight which is comparable to standard antidiabetic drug metformin.
Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
Preeti
P
Rawat
Manmeet
M
Kumar
Neha
N
Rahuja
Daya Shankar
DS
Lal Srivastava
Arvind Kumar
AK
Srivastava
Rakesh
R
Maurya
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002460:Cell Line; D047188:Chalcones / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D010636:Phenols / Q000737:chemistry*; D035721:Pterocarpus / Q000737:chemistry; D051381:Rats; D013329:Structure-Activity Relationship; D034403:Ulmus / Q000737:chemistry
D001786:Blood Glucose; D047188:Chalcones; D005960:Glucosides; D007004:Hypoglycemic Agents; D010636:Phenols