Dental abnormalities and oral health in patients with Hypophosphatemic rickets.
BACKGROUND
Hypophosphatemic rickets represents a group of heritable renal disorders of phosphate characterized by hypophosphatemia, normal or low serum 1,25 (OH)2 vitamin D and calcium levels. Hypophosphatemia is associated to interglobular dentine and an enlarged pulp chambers.


OBJECTIVE
Our goal was to verify the dental abnormalities and the oral health condition in these patients.


METHODS
Prospective study of oral conditions in patients with Hypophosphatemic rickets. This report employed a simple method to be easily reproducible: oral clinical exam and radiographic evaluation.


RESULTS
Fourteen patients were studied, 5 males, median age of 11 years (4 to 26). Occlusion defects (85,7%) and enamel hypoplasia (57,1%) were significant more frequently than dental abscesses (one patient). We observed enlarged pulp chambers in 43% of the patients and hypoplasia and dentin abnormalities in 14,3%. We could not detect a significant correlation between dental abnormalities and delayed treatment (p > 0,05). DMFT index for 6 to 12 years patients (n = 12) showed that the oral health is unsatisfactory (mean DMFT = 5).


CONCLUSIONS
Patients with Hypophosphatemic Rickets frequently present dental alterations and these are not completely recovered with the treatment, unless dental abscess and they need a periodical oral examination.
Pediatric Nephrology Unit, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Melissa Almeida
MA
Souza
Luiz Alberto Valente
LA
Soares Junior
Marcela Alves Dos
MA
Santos
Maria Helena
MH
Vaisbich
D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003744:Dental Enamel Hypoplasia / Q000000981:diagnostic imaging*; D003766:Dental Occlusion; D003786:Dental Pulp Cavity / Q000000981:diagnostic imaging*; D053098:Familial Hypophosphatemic Rickets / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D009909:Oral Health / Q000592:standards*; D011446:Prospective Studies; D011859:Radiography; D055815:Young Adult