A piperidine alkaloid and limonoids from Arisaema decipiens, a traditional antitumor herb used by the Dong people.
A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as (-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl) piperidine (1), 6-deacetylnimbin (2), 28-deoxonimbolide (3) and nimbin (4). The N-methylated derivative (1a) of 1 was synthesized. Compound 1 exhibited weak inhibitory activity against the MCF-7 cell line, while compound 1a showed potential inhibitory activity against the MCF-7 cell line with an IC₅₀ value of 4.6 μM and weak inhibitory activity against K562 and SK-OV-3 cells. This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine.
Kunming Institute of Botany, Chinese Academy of Sciences, China.
Fu-Wei
FW
Zhao
Min
M
Luo
Yue-Hu
YH
Wang
Ma-Lin
ML
Li
Gui-Hua
GH
Tang
Chun-Lin
CL
Long
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031057:Arisaema / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D005006:Ethnicity; D005260:Female; D006801:Humans; D036701:Limonins / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry
C558506:(-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl)piperidine; C552925:6-deacetylnimbin; D000470:Alkaloids; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D036701:Limonins; D010880:Piperidines; C062897:28-deoxonimbolide; C008621:nimbin