Treatment and monitoring of coagulation abnormalities in children undergoing heart surgery.
Bleeding is a considerable clinical problem during and after pediatric heart surgery. While the primary cause of bleeding is surgical trauma, its treatment is often complicated by the presence of coagulopathy. The principle causes of coagulopathy are discussed to provide a context for treatment. The role of laboratory and point of care tests, which aim to identify the cause of bleeding in the individual patient, is also discussed. An attempt is made to examine the current evidence for available therapies, including use of blood products and, more recently proposed, approaches based on human or recombinant factor concentrates.
Jackson Rees Department of Paediatric Anaesthesia, Alder Hey Children's Hospital, Eaton Road, Liverpool, UK. philip.arnold@alderhey.nhs.uk
Philip
P
Arnold
D001688:Biological Products; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000628:therapy*; D001780:Blood Coagulation Tests; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016343:Monitoring, Intraoperative / Q000379:methods*; D019095:Point-of-Care Systems
D001688:Biological Products