Reconstitution of coronary vasculature in ischemic hearts by plant-derived angiogenic compounds.
BACKGROUND
Coronary heart diseases (CHD) remain the most prevalent cause of premature death. Substantial growth of new collateral coronary vessels to the ischemic region would provide reconstitution of the occluded arteries and correction of heart ischemia. However, this remains an impossible mission with current advances.


METHODS
Incomplete ligation of left anterior descending (LAD) coronary artery was applied in rat resulting in partial occlusion of LAD. This chronic CHD model was employed to assess the therapeutic angiogenesis of Angio-T using ECG and echocardiography. Histological analysis was performed to provide substantial evidence for therapeutic angiogenesis in ischemic hearts with the possible involvement of JAK-STAT signaling pathway investigated.


RESULTS
Angio-T stimulated growth of new collateral microvessels in ischemic hearts and progressively improved heart functional performance 2 weeks post treatment. The involvement of JAK/STAT signaling pathway in Angio-T stimulated growth of new collateral coronary vessels in ischemic hearts was demonstrated.


CONCLUSIONS
The substantial therapeutic angiogenesis of Angio-T in ischemic hearts was demonstrated that may provide a more effective solution for non-interventional treatment of chronic CHD.
Key Laboratory for Regenerative Medicine of Ministry of Education of China, China.
Hao
H
Chen
Peng
P
Peng
Lei
L
Cheng
Xiaoli
X
Lin
Sylvie S W
SS
Chung
Ming
M
Li
D043925:Angiogenesis Inducing Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002478:Cells, Cultured; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D043925:Angiogenesis Inducing Agents; D010936:Plant Extracts