[Renal malakoplakia: an underestimate cause of renal failure].
Malakoplakia is an inflammatory granulomatous disease induced by defective phagocytic activity of macrophage. Malakoplakia is histologically characterized by the presence of Michaelis-Gutmann bodies in macrophages. Although not uncommon in the genito-urinary tract, isolated malakoplakia of the kidney is rarely found. Its main clinical presentation associates acute renal failure and acute pyelonephritis. The clue for diagnosis of renal malakoplakia is based on renal biopsy showing Michaelis-Gutmann bodies. Establishing the diagnosis of renal malakoplakia is essential as it determines the choice of antibiotics and duration of treatment. Prognosis remains poor, leading frequently to chronic renal failure. In this paper, we report four cases of renal malakoplakia and discuss clinical presentation, biological and pathological features, treatment and prognosis of this disease.
Service de néphrologie médecine interne, centre hospitalier de Valenciennes, avenue Desandrouin, 59300 Valenciennes, France. maitedaroux@hotmail.fr
Maïté
M
Daroux
Marie
M
Frimat
Tristan
T
Mirault
Dominique
D
Fleury
Vincent
V
Lemaitre
Laure-Hélène
LH
Noel
Philippe
P
Vanhille
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D001706:Biopsy; D003928:Diabetic Nephropathies / Q000150:complications; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008103:Liver Cirrhosis / Q000150:complications; D008264:Macrophages / Q000473:pathology; D008287:Malacoplakia / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D051437:Renal Insufficiency / Q000209:etiology*; D012307:Risk Factors; D016896:Treatment Outcome; D014815:Vitamins / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D014815:Vitamins; D001205:Ascorbic Acid