Neurocognitive recovery in SMART syndrome: a case report.
BACKGROUND
Stroke-like migraine attacks after radiation therapy, or SMART syndrome, is characterised by migraine-like headache with or without aura, transient neurological dysfunction, including seizures, and gyriform enhancement on magnetic resonance imaging (MRI) which resolves over a period of weeks. Detailed neuropsychological characterisation in SMART syndrome is lacking and there are no published data on the course and pattern of neurocognitive recovery.


RESULTS
The acute clinical presentation was one of unstable, fluctuating neurocognitive disturbances, complicated by seizure activity, followed by a longer term lag in the recovery of focal neuropsychological deficits which, we believe, was due to the more slowly resolving cerebral effects of SMART.


CONCLUSIONS
To our knowledge, this is the first case of SMART syndrome in which neuropsychological functioning has been comprehensively and serially examined. This case is also unique due to the development of complex partial seizures. We suggest that epileptiform activity during clinical seizures should not be regarded as inconsistent with a diagnosis of SMART, provided that the seizures do not explain the onset of the other clinical and radiological features.
Neurosciences Department, University of Melbourne, Heidelberg 3084, Victoria, Australia. jbrad@unimelb.edu.au
Jennifer
J
Bradshaw
Luke
L
Chen
Michael
M
Saling
Greg
G
Fitt
Andrew
A
Hughes
Ariane
A
Dowd
D000328:Adult; D001921:Brain / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000532:radiotherapy / Q000556:secondary; D008881:Migraine Disorders / Q000209:etiology / Q000503:physiopathology; D009483:Neuropsychological Tests; D011878:Radiotherapy / Q000009:adverse effects*; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D013577:Syndrome