Pathophysiological effects and changes in potassium, ionised calcium, glucose and haemoglobin early after severe blunt chest trauma.
BACKGROUND
Severe lung contusion is often observed after blunt chest trauma due to traffic accidents or fall from heights, but may also occur after a non-penetrating ballistic impact against body armour. Such trauma has been designated behind armour blunt trauma (BABT). Our aim in the present study has been to evaluate pathophysiological changes and compensatory mechanisms that occur early after such severe lung contusion.


METHODS
Twelve pigs wearing body armour were shot with a 7.62mm assault rifle to produce a standardised pulmonary contusion. Exposed animals were compared with five control animals shot with blank ammunition. Physiological parameters and levels of potassium, glucose, haemoglobin, calcium, lactate and pH were monitored for two hours after the shot.


RESULTS
The impact induced severe pulmonary contusion with apnoea, desaturation and hypotension in all exposed animals. Increased haemoglobin, glucose and severe hyperkalaemia were seen shortly after impact. Seven of twelve animals died due to the trauma. Dense cardiac tissue was observed during post mortem examination in six of the animals that died during the experimental course.


CONCLUSIONS
In conclusion, this study has shown that life-threatening hyperkalaemia occurs early after severe lung contusion. Moreover, dense cardiac tissue and early increase of haemoglobin and glucose are intriguing findings that should be investigated in future studies.
Experimental Traumatology Research Unit, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. david.rocksen@ki.se
David
D
Rocksén
Dan
D
Gryth
Henrik
H
Druid
Jenny
J
Gustavsson
Ulf P
UP
Arborelius
D000818:Animals; D002118:Calcium / Q000097:blood*; D004195:Disease Models, Animal; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D055370:Lung Injury / Q000097:blood*; D011188:Potassium / Q000097:blood*; D011481:Protective Clothing; D013552:Swine; D013997:Time Factors; D014948:Wounds, Gunshot; D014949:Wounds, Nonpenetrating / Q000097:blood*
D006454:Hemoglobins; D011188:Potassium; D002118:Calcium