Synthesis of poly(methyl methacrylate)-block-poly(L-histidine) and its use as a hybrid silver nanoparticle conjugate.
Poly[(methyl methacrylate)-block-poly(L-histidine)] (PMMA-b-PHIS) was synthesized by combining atom transfer radical polymerization and living ring-opening polymerization of alpha-amino acid-N-carboxyanhydride. The resulting hybrid block copolymer forms reverse micelles in the mixture solution of water and N,N-dimethylformamide (DMF) and self-assembles into PHIS/PMMA core/shell spheres with controllable size in the range of 80 to 250 nm depending on the micellization temperature. The self-assembly of PMMA-b-PHIS was carried out in H2O/DMF (3/7) mixture in the presence of AgNO3. Reduction of the resulting Ag ions encapsulated inside of the reverse micelles yielded an attractive Ag nanoparticle core/polymer shell conjugate system.
The WCU Center for Synthetic Polymer Bioconjugate Hybrid Materials, Department of Polymer Science and Engineering, Pusan National University, Busan 609-735, Korea.
Nam Ho
NH
Shin
Jin Kyu
JK
Lee
Haiqing
H
Li
Chang-Sik
CS
Ha
Yury A
YA
Shchipunov
Il
I
Kim
D006639:Histidine / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D058726:Nanoconjugates / Q000737:chemistry*; D036103:Nanotechnology; D010316:Particle Size; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D008823:Micelles; D058726:Nanoconjugates; C033223:polyhistidine; D012834:Silver; D006639:Histidine; D019904:Polymethyl Methacrylate