FHA domain pThr binding specificity: it's all about me.
The FHA domain is a phospho-peptide binding module involved in a wide range of cellular pathways, with a striking specificity for phospho-threonine over phospho-serine binding partners. Biochemical, structural, and dynamic simulations analysis allowed Pennell and colleagues to unravel the molecular basis of FHA domain phospho-threonine specificity.
Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, AB T6G2H7, Canada.
Nicolas
N
Coquelle
J N Mark
JN
Glover