Herbal medicines and nutraceuticals for diabetic vascular complications: mechanisms of action and bioactive phytochemicals.
Diabetes is one of the most prevalent chronic diseases throughout the world. The majority of its complications arise from vascular-related inflammation apparently initiated by endothelial cell injury. One cause of this injury has been attributed to hyperglycaemia-induced reactive oxygen species. Consequently, current drug developmental strategy has targeted specific inflammatory and oxidative stress pathways for the prevention of diabetic vascular complications. Herbal medicines have traditionally been used for the treatment of diabetes and its complications. In fact, current pre-clinical and clinical studies have demonstrated that many of them exhibit potent anti-inflammatory and anti-oxidative properties, and have also identified the active phytochemicals responsible for their activities. The present review summarises the latest research on the molecular mechanisms of diabetic vascular complications, and evaluates the level of scientific evidence for common herbal medicines and their bioactive phytochemicals. These agents have been shown to be effective through various mechanisms, particularly the NF-κB signalling pathways. Overall, herbal medicines and nutraceuticals, as well as their bioactive components, which exhibit anti-inflammatory and anti-oxidative properties, provide a promising approach for the prevention and treatment of diabetic complications.
Herbal Medicines Research and Education Centre, Faculty of Pharmacy, University of Sydney, NSW 2006, Australia. george.li@sydney.edu.au
Eshaifol A
EA
Omar
Antony
A
Kam
Ali
A
Alqahtani
Kong M
KM
Li
Valentina
V
Razmovski-Naumovski
Srinivas
S
Nammi
Kelvin
K
Chan
Basil D
BD
Roufogalis
George Q
GQ
Li
D048909:Diabetes Complications / Q000188:drug therapy*; D019587:Dietary Supplements; D029001:Herbal Medicine; D006801:Humans; D014652:Vascular Diseases / Q000188:drug therapy*