Effects of oxytocin on recollections of maternal care and closeness.
Although the infant-caregiver attachment bond is critical to survival, little is known about the biological mechanisms supporting attachment representations in humans. Oxytocin plays a key role in attachment bond formation and maintenance in animals and thus could be expected to affect attachment representations in humans. To investigate this possibility, we administered 24 IU intranasal oxytocin to healthy male adults in a double-blind, placebo-controlled, crossover designed study and then assessed memories of childhood maternal care and closeness--two features of the attachment bond. We found that the effects of oxytocin were moderated by the attachment representations people possess, with less anxiously attached individuals remembering their mother as more caring and close after oxytocin (vs. placebo) but more anxiously attached individuals remembering their mother as less caring and close after oxytocin (vs. placebo). These data contrast with the popular notion that oxytocin has broad positive effects on social perception and are more consistent with the animal literature, which emphasizes oxytocin's role in encoding social memories and linking those memories to the reward value of the social stimulus.
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. jennifer.bartz@mssm.edu
Jennifer A
JA
Bartz
Jamil
J
Zaki
Kevin N
KN
Ochsner
Niall
N
Bolger
Alexander
A
Kolevzon
Natasha
N
Ludwig
John E
JE
Lydon
D000281:Administration, Intranasal; D000328:Adult; D000818:Animals; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008425:Maternal Behavior; D008568:Memory / Q000187:drug effects*; D009769:Object Attachment; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D010919:Placebos / Q000494:pharmacology; D012938:Social Perception
D010919:Placebos; D010121:Oxytocin