Immune response of submissive and aggressive mice under conditions of opioid receptor activation.
Experiments on the model of paired sensory contact demonstrated that stimulation of immune response in aggressive CBA and C57Bl/6J mice with 10- and 20-day experience of victories, respectively, was prevented by selective δ(2)- and -opioid receptor agonists DSLET and κ-opioid receptor agonists rimorphin in a dose of 100 microg/kg. In C57Bl/6J mice with depression-like behavior, normalization (but not suppression) of the immune response under conditions of μ-opioid receptor stimulation (100 microg/kg) was observed. Selective modulation of activity of a certain type of opioid receptors can normalize the immune function modified during the formation of a certain behavioral type.
Laboratory of Mechanisms of Neurochemical Modulation, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. cheido@physiol.ru
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D000374:Aggression / Q000187:drug effects*; D000818:Animals; D004399:Dynorphins / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D056747:Immunomodulation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D017465:Receptors, Opioid, delta / Q000819:agonists*; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D017450:Receptors, Opioid, mu / Q000819:agonists*
D004723:Endorphins; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D004743:Enkephalin, Leucine; D004399:Dynorphins; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; C036200:rimorphin