Cucurbitane triterpenoids from Momordica charantia and their cytoprotective activity in tert-butyl hydroperoxide-induced hepatotoxicity of HepG2 cells.
Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.
Department of Biological Science and Technology, Meiho University, Taiwan.
Chiy-Rong
CR
Chen
Yun-Wen
YW
Liao
Lai
L
Wang
Yueh-Hsiung
YH
Kuo
Hung-Jen
HJ
Liu
Wen-Ling
WL
Shih
Hsueh-Ling
HL
Cheng
Chi-I
CI
Chang
D019610:Cytoprotection / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D029777:Momordica charantia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
C556725:22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one; C556729:25,26,27-trinorcucurbit-5-ene-3,7,23-trione; C556727:3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid; D006027:Glycosides; D014315:Triterpenes; C514277:cucurbitane; D006861:Hydrogen Peroxide