Ingestion of polydextrose increase the iron absorption in rats submitted to partial gastrectomy.
OBJECTIVE
To investigate whether polydextrose stimulates iron absorption in rats submitted to partial gastrectomy and sham operated.


METHODS
The rats were submitted to partial gastrectomy (Billroth II) or laparotomy (sham-operated control), in groups of 20 and 20 each respectively. The animals were fed with a control diet (AIN-93M) without polydextrose or a diet containing polydextrose (50g/Kg of diet) for eight weeks. They were divided into four subgroups: sham-operated and Billroth II gastrectomy and with or without polydextrose. Two animals died during the experiment. All rats submitted to gastrectomy received B-12 vitamin (intramuscular) each two weeks. The hematocrit and hemoglobin concentration were measured at the start and on day 30 and 56 after the beginning of the experimental period. At the end of the study, the blood was collected for determination of serum iron concentration.


RESULTS
The diet with polydextrose reduced the excretion of iron. Apparent iron absorption was higher in the polydextrose fed groups than in the control group. The haematocrit and haemoglobin concentration were lower after Billroth II gastrectomy rats fed the control diet as compared to the polydextrose diet groups.


CONCLUSIONS
Polydextrose increase iron absorption and prevents postgastrectomy anemia.
DEPAN, FEA, UNICAMP, Campinas, SP, Brazil.
Elisvânia Freitas dos
EF
Santos
Kathia Hitomi
KH
Tsuboi
Marina Rachel
MR
Araújo
Mônica Almeida
MA
Falconi
Arthur C
AC
Ouwehand
Nelson Adami
NA
Andreollo
Celio Kenji
CK
Miyasaka
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry*; D005743:Gastrectomy / Q000379:methods*; D005936:Glucans / Q000008:administration & dosage*; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000097:blood*; D008297:Male; D056692:Prebiotics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D005936:Glucans; D056692:Prebiotics; D007501:Iron; C033375:polydextrose