Redox active secondary metabolites.
Various secondary metabolites from plants, bacteria and fungi are redox active and able to modulate the intracellular redox equilibrium in living cells. Many of these compounds behave as antioxidants, yet some of them also cause oxidative modifications, which may ultimately result in cell death. Natural isothiocyanates and xanthohumol, for instance, appear to act specifically in and against cells with a disturbed redox balance, such as certain cancer cells. Similarly, polysulfane and pyocyanin derivatives employ the glutathione antioxidant defense system of cells to generate a lethal cocktail of reactive oxygen species. Together, these redox-modulating metabolites provide promising new leads to target selectively certain cancer cells. They may also be useful in the treatment of autoinflammatory diseases.
Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus, D-66123 Saarbruecken, Germany. c.jacob@mx.uni-saarland.de
Claus
C
Jacob
Vincent
V
Jamier
Lalla Aicha
LA
Ba
D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism
D001688:Biological Products; D017382:Reactive Oxygen Species; D005978:Glutathione