Adipocytokines in subjects with and without ischemic cerebrovascular disease.
OBJECTIVE
To investigate adipocytokines in patients with ischemic cerebrovascular disease and to develop an association between them.


METHODS
In this study plasma adiponectin, leptin and Interleukin 6 (IL 6) concentration were measured by ELISA. Blood glucose and lipid profile was done by standard kit methods.


RESULTS
A total of 80 subjects with and without CVD were studied. The mean plasma level of IL6 of the forty patients with ischemic CVD was significantly higher than that of the forty subjects without CVD (41.64 + 2.50 versus 22.76 + 0.76 pg/mL; P < 0.001). The mean plasma level of adiponectin was significantly lower in patients with ischemic CVD than that of subjects without CVD (4.36 +/- 0.21 microg/mL versus 6.9 +/-0.241microg/mL; P < 0.001). Serum leptin concentrations were significantly higher (p < 0.001) in stroke patients (51.61 + 1.39) as compared with controls (37.76 + 1.207). Leptin levels were significantly negatively correlated with adiponectin (P < 0.01) and significantly positively correlated (P < 0.01) with interleukin 6 in stroke patients.


CONCLUSIONS
Present report provides additional support to the evidence of involvement of cytokines in inflammatory immune response of patients with cerebrovascular disease.
Department of Biochemistry, Ziauddin University, Karachi, Pakistan. aneelajaleel@hotmail.com
Anila
A
Jaleel
Saima
S
Aqil
Shahila
S
Jaleel
Farhan
F
Jaleel
D052242:Adiponectin / Q000097:blood / Q000276:immunology; D000368:Aged; D002545:Brain Ischemia / Q000276:immunology* / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology*; D020738:Leptin / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000276:immunology / Q000378:metabolism
C499918:ADIPOQ protein, human; D052242:Adiponectin; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin