Applications of aptamers in nanodelivery systems in cancer, eye and inflammatory diseases.
Aptamers are an interesting class of molecules that have potential in many facets of human health. They are characterized by high affinity and specificity to their targets, are small in size, have similar properties to antibodies, but are made synthetically. All of these properties, among others, give aptamers the potential to diagnose, image and treat like no other molecules. By combining the unique properties of aptamers with the ever expanding field of nanotechnology and all it has to offer, we are entering a very promising new area of targeted nanodelivery treatments. These treatments have found success in the complex disease processes of cancer, eye and inflammatory diseases.
Laboratory of Immunology & Molecular Biomedical Research, Centre for Biotechnology & Interdisciplinary Biosciences (BioDeakin), Institute for Technology & Research Innovation (ITRI), Geelong Technology Precinct, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia. jagat.kanwar@deakin.edu.au
Jagat R
JR
Kanwar
Rajiv R
RR
Mohan
Rupinder K
RK
Kanwar
Kislay
K
Roy
Raj
R
Bawa
D000818:Animals; D052157:Aptamers, Nucleotide / Q000008:administration & dosage* / Q000737:chemistry; D052158:Aptamers, Peptide / Q000008:administration & dosage* / Q000737:chemistry; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
D052157:Aptamers, Nucleotide; D052158:Aptamers, Peptide