Angiopoietin-1 and endostatin levels in cord plasma predict the development of bronchopulmonary dysplasia in preterm infants.
OBJECTIVE
To determine whether angiopoietin-1 and endostatin levels in the cord blood could predict the subsequent development of bronchopulmonary dysplasia (BPD) in preterm infants.


METHODS
A total of 102 preterm (gestational age ≤ 32 weeks) infants (28 infants developed BPD and 74 had no BPD) were enrolled in the study. Cord plasma levels of angiopoietin-1 and endostatin were measured by enzyme-linked immunosorbent assay.


RESULTS
Preterm infants who subsequently developed BPD had significantly lower cord plasma levels of angiopoietin-1 than those who did not (p < 0.001). Our results showed that cord plasma levels of endostatin were significantly higher in infants with BPD than in those without (p < 0.001). In infants with BPD, angiopoietin-1 levels in cord plasma correlated negatively with endostatin (r = -0.48; p = 0.008).


CONCLUSIONS
In preterm infants, low-angiopoietin-1 and high-endostatin levels in cord plasma at birth predict the subsequent development of BPD.
Department of Pediatrics, College of Medicine, King Khalid University, Abha, Saudi Arabia. walidabdo2020@gmail.com
Walid Abdel Wahab
WA
Mohamed
Walid H
WH
Niyazy
Ahmed A
AA
Mahfouz
D042683:Angiopoietin-1 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000097:blood / Q000175:diagnosis*; D043169:Endostatins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011379:Prognosis; D011446:Prospective Studies
C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D015415:Biomarkers; D043169:Endostatins