The effect of additional propofol on intubation conditions.
OBJECTIVE
To evaluate whether an additional dose of propofol prior to intubation improves intubation conditions.


METHODS
Prospective, randomized, double-blinded clinical study.


METHODS
Operating room in university hospital.


METHODS
102 ASA physical status I and II patients undergoing elective surgery with general anesthesia.


METHODS
Patients received different doses of propofol (Groups A and B, 1.5 mg/kg; Group C, 2 mg/kg) preceded by fentanyl (1.5 μg/kg). In Group B, additional propofol (0.5 mg/kg) was administered 45 seconds after rocuronium. Intubation was performed 90 seconds after administration of rocuronium 0.6 mg/kg. Intubation conditions and hemodynamic variables were compared among the three groups.


RESULTS
Intubation conditions were acceptable in 61.8% of Group A patients, 58.8% of Group C patients, and 91.1% of Group B patients (P = 0.005). Mean arterial pressure (MAP) three minutes after intubation was significantly lower in Group C (P = 0.006 vs. Groups A and B), while MAP did not differ between Group A and Group B.


CONCLUSIONS
Administration of an additional dose of propofol (0.5 mg/kg) prior to intubation may significantly improve intubation conditions without increasing the frequency of hypotension.
Department of Anesthesiology and Pain Medicine, College of Medicine, Dankook University, Cheonan, 330-715 Korea. mmauss73@dankook.ac.kr
Min A
MA
Kwon
Seok K
SK
Kim
Dae G
DG
Jeon
Jae K
JK
Song
Won I
WI
Kim
D000328:Adult; D000368:Aged; D000732:Androstanols / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies; D000077123:Rocuronium
D000732:Androstanols; D018686:Anesthetics, Intravenous; D000077123:Rocuronium; D015742:Propofol