Palladium catalyzed ring opening of furans as a route to α,β-unsaturated aldehydes.
Furans may be ring opened via pallado-catalyzed reactions leading to α,β-unsaturated aldehydes and ketones tethered to indole and isoquinoline moieties. Besides their synthetic interest, these fragmentations bring interesting elements into the discussion around the reaction mechanisms involved in palladium C-H activations of electron-rich heterocycles.
Laboratoire Chimie et Procédés, UMR 7652, Ecole Nationale Supérieure des Techniques Avancées, 32 Bd Victor, 75015 Paris, France. laurent.elkaim@ensta.fr
Laurent
L
El Kaïm
Laurence
L
Grimaud
Simon
S
Wagschal