Excavatoids O and P, new 12-hydroxybriaranes from the octocoral Briareum excavatum.
Two new 12-hydroxybriarane diterpenoids, designated as excavatoids O (1) and P (2), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1 and 2 were established on the basis of extensive spectral data analysis. Excavatoid P (2) is the first metabolite which possesses a 6β -chlorine atom in briarane analogues.
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw
Ping-Jyun
PJ
Sung
Gung-Ying
GY
Li
Yin-Di
YD
Su
Mei-Ru
MR
Lin
Yu-Chia
YC
Chang
Ting-Hsuan
TH
Kung
Chan-Shing
CS
Lin
Yung-Husan
YH
Chen
Jui-Hsin
JH
Su
Mei-Chin
MC
Lu
Jimmy
J
Kuo
Ching-Feng
CF
Weng
Tsong-Long
TL
Hwang
D000818:Animals; D037421:Anthozoa / Q000254:growth & development / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D010196:Pancreatic Elastase / Q000378:metabolism; D013237:Stereoisomerism
D004224:Diterpenes; C558822:excavatoid O; C558821:excavatoid P; D010196:Pancreatic Elastase