[Immunotherapy and long-term chemoprophylaxis in prevention of recurrent urinary infections in women].
In clinical practice, management of urinary infections is a frequent task. Long-term prophylactic administration of small-dose chemotherapy had been shown to prevent recurrent urinary infections. Recently, an interest increases in applying immunotherapy in this indication. The authors compare immunomodulators Urovaxom and Luivac as part ofa combined immunotherapy and chemoprophylaxis regimens with small doses of fluorochinolones over 12 months in women with recurrent urinary infections. This treatment statistically significantly decreases occurrence of relapses and has been relatively well-tolerated. Unlike previous studies, we managed to isolate resistant strains producing the so-called extended-spectrum beta-lactamases (ESBL) and this may provide a signal for revision of some therapeutic approaches. In line with international recommendations, we prefer immunotherapy as comparably effective but safer treatment modality than the long-term chemoprophylaxis with fluorochinolones.
II. klinika geriatrie Lekárskej fakulty UK a FNsP Milosrdní bratia, spol. s r.o., Bratislava, Slovenská republika. skrcmery@milosrdni.sk
S
S
Krcméry
J
J
Hromec
Z
Z
Gábrisová
R
R
Tahotný
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000942:Antigens, Bacterial / Q000627:therapeutic use*; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D055502:Secondary Prevention; D014552:Urinary Tract Infections / Q000382:microbiology / Q000517:prevention & control*; D055815:Young Adult
D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; C078795:LW 50020; C050501:OM 89; D002939:Ciprofloxacin