WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease.
WISP1 is a secreted, matricellular protein allocated to the CCN protein family. The CCN protein family consists of six, modular structured, secreted proteins. WISP1 is mainly expressed during organ development and under diseased conditions, such as fibrosis or cancer. Its expression is associated with proliferation, cytoprotection, as well as extracellular matrix production, thereby representing a highly attractive therapeutical target for future applications.
Comprehensive Pneumology Center, Ludwig-Maximilians-University, University Hospital Grosshadern, Max-Lebsche-Platz 31, 81377 Munich, Germany.
Barbara
B
Berschneider
Melanie
M
Königshoff
D000818:Animals; D004194:Disease; D047108:Embryonic Development; D006801:Humans; D008954:Models, Biological; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
D011518:Proto-Oncogene Proteins