Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics.
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, 21201, USA.
Jeremy L
JL
Yap
Shilpa
S
Worlikar
Alexander D
AD
MacKerell
Paul
P
Shapiro
Steven
S
Fletcher
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D011485:Protein Binding / Q000187:drug effects; D021281:Quantitative Structure-Activity Relationship; D015398:Signal Transduction / Q000187:drug effects; D054852:Small Molecule Libraries / Q000378:metabolism / Q000494:pharmacology*; D048490:raf Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D054852:Small Molecule Libraries; D048490:raf Kinases; D048049:Extracellular Signal-Regulated MAP Kinases