Intercellular induction of apoptosis signalling pathways.
Intercellular signalling plays an important role in the progression of a transformed cell to a tumour. In order to characterise the underlying mechanisms, a well-defined model cell system of intercellular induction of apoptosis was used where neighbouring normal cells can selectively eliminate transformed cells. In the absence of non-transformed cells, the induction of apoptosis in transformed 208Fsrc3 cells occurs via autocrine destruction and is dominated by peroxidase (PO), which initiates the PO/hypochlorous acid signalling pathway at high local cell densities. However, when the transformed cells are co-cultured with the non-transformed 208F cells, apoptosis in transformed cells additionally occurs as a result of intercellular signalling with the non-transformed cells and is predominantly due to the production of nitric oxide (NO(•)), which initiates the NO(•)/peroxynitrite pathway.
CRUK/MRC Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
Abdelrazek B
AB
Abdelrazzak
Peter
P
O'Neill
Mark A
MA
Hill
D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology*; D005347:Fibroblasts / Q000166:cytology* / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D015398:Signal Transduction
D009569:Nitric Oxide