Premise, promise, and potential limitations of invasive devices to treat hypertension.
Invasive device-based therapies for drug-resistant hypertension are undergoing active clinical investigation. The two approaches are 1) permanent implantation of a carotid baroreceptor pacemaker and 2) radiofrequency catheter ablation of the renal nerves. Both are designed to reduce the sympathetic nervous system component of drug-resistant hypertension. Several excellent comprehensive articles have reviewed each of these devices separately. In contrast, this brief article aims to provide a conceptual framework for evaluating the premise, promise, and potential limitations of both invasive antihypertensive therapies.
Hypertension Center, Cedars-Sinai Heart Institute, Los Angeles, CA 90048, USA. Elizabeth.Martin@cshs.org
Elizabeth A
EA
Martin
Ronald G
RG
Victor
D000959:Antihypertensive Agents / Q000627:therapeutic use; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D017115:Catheter Ablation / Q000379:methods*; D004351:Drug Resistance; D006801:Humans; D006973:Hypertension / Q000601:surgery* / Q000628:therapy; D010138:Pacemaker, Artificial; D017211:Treatment Failure
D000959:Antihypertensive Agents