Immunosuppressive and anti-inflammatory activities of sinomenine.
Sinomenine (SN), a pure compound extracted from the Sinomenium acutum plant, has been found to inhibit T- and B-lymphocyte activation, proliferation and function and to interfere with the differentiation, recruitment and function of several other cell types, such as dendritic cells (DC). SN has demonstrated its potential anti-inflammatory role for treating immune-related disorders in experimental animal models and in some clinical applications. This review will summarize its potential effects, mechanisms and applications.
National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China. wangqx64@hotmail.com
Quanxing
Q
Wang
Xiao-Kang
XK
Li
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D009019:Morphinans / Q000737:chemistry / Q000494:pharmacology*; D032841:Sinomenium / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D009019:Morphinans; C009271:sinomenine