Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk.
In this study, we aimed to investigate a possible association of the COX-2 polymorphisms (-765G→C and -1195A→G) and with the risk of developing epithelial ovarian carcinoma (EOC). COX-2 gene polymorphisms was investigated in 111 healthy women and 57 patients with EOC. Individuals who had -765 CG, -1195 AA genotype, and -765 C allele had increased risk for ovarian carcinoma (P < 0.01) and individuals with -765 GG, -1195 AG genotypes and -1195 G allele seem to be protected from ovarian carcinoma (P < 0.01). Haplotype analysis confirmed the association of COX-2 gene variants with ovarian carcinoma and revealed that the frequencies of -765C: -1195A haplotype frequencies was significantly higher in patients as compared with those of controls (P = 0.048). We state that there appears to be a modulating role for the COX-2 -1195A→G and -765G→C polymorphisms in the development of EOC. To the best of our knowledge, this is the first study to show such an association.
Department of Molecular Medicine, Institute for Experimental Medicine Research, Istanbul University, Vakif Gureba cad, 34390 Capa, Istanbul, Turkey. agachanb@yahoo.com
Bedia
B
Agachan Cakmakoglu
Rukset
R
Attar
Ozlem Timirci
OT
Kahraman
Altay Burak
AB
Dalan
Ahmet Cem
AC
Iyibozkurt
Ates
A
Karateke
Erkut
E
Attar
D000328:Adult; D000077216:Carcinoma, Ovarian Epithelial; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000201:enzymology* / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human