Duloxetine-related tardive dystonia and tardive dyskinesia: a case report.
Tardive dyskinesia and tardive dystonia are caused by dopamine receptor blocking agents, mostly antipsychotics and sometimes antidepressants or calcium channel blockers. Duloxetine-related tardive syndrome is rarely reported in the literature. We report one case of tardive dystonia and tardive dyskinesia occurring in a 58-year-old female with major depressive disorder, who developed distressing oral dyskinesia, mandibular dystonia with trismus and dystonia over left neck after treatment of duloxetine (30-60 mg per day) for 18 months. Despite discontinuation of duloxetine, she only obtained partial remission. Even though this association has been rarely reported, duloxetine may pose a potential risk of inducing tardive syndrome. Clinicians should cautiously detect early signs of movement abnormality when prescribing antidepressants.
Department of Psychiatry, Chang Gung University College of Medicine, Kaohsiung County, 83301, Taiwan.
Pei-Yi
PY
Chen
Pao-Yen
PY
Lin
Shin-Chiao
SC
Tien
Yung-Yee
YY
Chang
Yu
Y
Lee
D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D000068736:Duloxetine Hydrochloride; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis / Q000209:etiology*; D009460:Neurologic Examination / Q000187:drug effects; D013876:Thiophenes / Q000009:adverse effects* / Q000627:therapeutic use
D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride