Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma.
OBJECTIVE
It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of β-catenin in OSCC of the tongue and its correlation with tumor metastasis.


METHODS
Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the β-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++).


RESULTS
It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no difference between the studied groups.


CONCLUSIONS
Based on these results, it can be concluded that the immunoexpression of β-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue.
UFRN, Natal, RN, Brazil.
Roseana de Almeida
Rde A
Freitas
Ericka Janine Dantas
EJ
Silveira
João Paulo Borges da
JP
Silveira
Fabyanne Mazutti da
FM
Silva
Rivadávio Fernandes Batista de
RF
Amorim
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D018709:Statistics, Nonparametric; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology; D051176:beta Catenin / Q000378:metabolism*
D014408:Biomarkers, Tumor; D051176:beta Catenin