Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.
Department of Microbiology, Columbia University, New York, New York 10032, USA.
Silvia
S
Argimón
Saranna
S
Fanning
Jill R
JR
Blankenship
Aaron P
AP
Mitchell
D000935:Antifungal Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D023082:Defensins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000378:metabolism*; D057166:High-Throughput Screening Assays; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D015398:Signal Transduction; D023083:beta-Defensins / Q000494:pharmacology*
D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; C422950:DEFB103A protein, human; C106641:DEFB4A protein, human; D023082:Defensins; D005656:Fungal Proteins; D023083:beta-Defensins; D020928:Mitogen-Activated Protein Kinases