Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy loss.
Compared with 537 parous controls with no history of pregnancy loss, a lower thrombomodulin-related inhibition of the endogenous thrombin potential was measured in 264 cases with previous unexplained pregnancy loss, especially when losses occurred between 9 and 12 weeks of gestation. Adjusting age, protein S, factor VIII, factor V Leiden, and prothrombin G20210A did not change the results.
Department of Internal Medicine and Chest Diseases, Brest University Hospital, La Cavale Blanche Hospital, Brest, France.
Luc
L
de Saint Martin
Jérôme
J
Duchemin
Caroline
C
Bohec
Francis
F
Couturaud
Dominique
D
Mottier
Michel
M
Collet
Marie-Thérèse
MT
Blouch
Elisabeth
E
Pasquier
D000328:Adult; D016022:Case-Control Studies; D020964:Embryo Loss / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood / Q000378:metabolism*; D013917:Thrombin / Q000032:analysis / Q000378:metabolism*; D018180:Thrombomodulin / Q000378:metabolism*; D015854:Up-Regulation
C546931:THBD protein, human; D018180:Thrombomodulin; D013917:Thrombin