Expression of early immune response genes during physical exercise.
Study by means of expression profiling with Human GeneChip ST1.0 microchips (Affymetrix) revealed 10 early immune response genes, whose expression was modified after short-term intense physical exercise. They include genes for immunoglobulin-like receptors of natural killer cell, genes for IL-2Rβ and IL-18RAP receptors, and two genes for functional proteins (perforin 1 and granzyme B) that provide the cytotoxic potential of killer cells. Possible mechanisms of stimulation, activation of the receptor apparatus, and cytotoxic effect on natural killer cells are evaluated under conditions of physical exercise.
All-Russian Institute of Physical Culture and Sport, Moscow, Russia. varja.shlepzova@gmail.ru
V A
VA
Shleptsova
E V
EV
Trushkin
O A
OA
Bystryh
J I
JI
Davydov
N P
NP
Obrazcova
E S
ES
Grebenuk
A G
AG
Tonevitsky
D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation / Q000276:immunology / Q000502:physiology*; D053804:Granzymes / Q000378:metabolism; D006801:Humans; D053646:Interleukin-2 Receptor beta Subunit / Q000378:metabolism; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins / Q000378:metabolism; D053724:Receptors, Interleukin-18 / Q000378:metabolism; D055607:Receptors, Natural Killer Cell / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
D053646:Interleukin-2 Receptor beta Subunit; C510468:PRF1 protein, human; D052899:Pore Forming Cytotoxic Proteins; D053724:Receptors, Interleukin-18; D055607:Receptors, Natural Killer Cell; D054353:Perforin; D053804:Granzymes