[Involvement of nuclear domains in the cellular response to DNA damage].
All cells of human organism are continuously damaged, and a damage of the genetic material can be especially dangerous. The reaction of the cell to DNA damage is a complex process, which includes damage signaling, repair, apoptosis or cell death. It is connected with serious changes in the cell nucleus, which are caused by posttranslational modifications and dynamic relocalizations of proteins as well as alterations in the expression of many genes. These changes are not limited to the sites of DNA damage, but involve whole cell nucleus, including its domains: PML bodies, nucleolus and Cajal bodies.
Department of Molecular Genetics, University of Lodz, 12/16 Banacha St., 90-237 Lodz, Poland.
Daniel
D
Wysokiński
Janusz
J
Błasiak
Katarzyna
K
Woźniak
D017209:Apoptosis / Q000502:physiology; D002466:Cell Nucleolus / Q000378:metabolism; D020541:Coiled Bodies / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology*; D004265:DNA Helicases / Q000378:metabolism; D004260:DNA Repair; D015870:Gene Expression; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D000071156:Promyelocytic Leukemia Protein; D053484:RecQ Helicases / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C070576:PML protein, human; D004265:DNA Helicases; D053484:RecQ Helicases