Sterigmatocystins from the deep-sea-derived fungus Aspergillus versicolor.
Three new sterigmatocystin derivatives, oxisterigmatocystin A (1), oxisterigmatocystin B (2) and oxisterigmatocystin C (3), together with one known compound, 5-methoxysterigmatocystin (4), were isolated from the deep-sea-derived fungus Aspergillus versicolor. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4 were evaluated against the A-549 and HL-60 cell lines. Compound 4 exhibited moderate cytotoxicities against the A-549 and HL-60 cell lines with IC(50) value of 3.86 and 5.32 μM, respectively.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, PR China.
Shengxin
S
Cai
Tianjiao
T
Zhu
Lin
L
Du
Boyu
B
Zhao
Dehai
D
Li
Qianqun
Q
Gu
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000378:metabolism; D001230:Aspergillus / Q000302:isolation & purification* / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D012623:Seawater / Q000382:microbiology; D013057:Spectrum Analysis; D013241:Sterigmatocystin / Q000737:chemistry* / Q000302:isolation & purification* / Q000378:metabolism
D000970:Antineoplastic Agents; D013241:Sterigmatocystin