Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.
The synthesis and (19)F NMR spectroscopic properties are reported for three series of CF(3)-labelled lanthanide(III) complexes, based on mono- and diamide cyclen ligands. Analyses of variable temperature, pH and field (19)F, (17)O and (1)H NMR spectroscopic experiments are reported and the merits of a triphosphinate mono-amide complex defined by virtue of its favourable isomer distribution and attractive relaxation properties. These lead to an enhanced sensitivity of detection in (19)F magnetic resonance experiments versus a diamagnetic Y(III) analogue, paving the way for future shift and imaging studies.
Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE.
Kirsten H
KH
Chalmers
Mauro
M
Botta
David
D
Parker
D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D000080027:Cyclams; D003958:Diamide / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics
D056831:Coordination Complexes; D000080027:Cyclams; D006571:Heterocyclic Compounds; D028581:Lanthanoid Series Elements; D008024:Ligands; D003958:Diamide; D005461:Fluorine; C038072:cyclen