Genetic factors determining the functional organization of neural circuits controlling rhythmic movements the murine embryonic parafacial rhythm generator.
In mammals, fetal movements governed by central pattern generators are essential for the development of adaptive behaviors such as breathing, walking, and chewing, which are vital after birth. Combining targeted mutations and genetic fate mapping can help to define the molecular determinants that control the development of these central pattern generators. In this chapter, recent results are presented on the embryonic parafacial (e-pF) rhythm generator, one of the two oscillators involved in controlling the breathing behavior and chemosensitive responsiveness.
Neurobiologie et Développement, UPR 3294, C.N.R.S., IFR 144 Neuro-Sud Paris, France.
J
J
Champagnat
M
M
Thoby-Brisson
G
G
Fortin
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D004622:Embryo, Mammalian / Q000033:anatomy & histology* / Q000502:physiology*; D018398:Homeodomain Proteins / Q000378:metabolism; D007395:Interneurons / Q000378:metabolism; D051379:Mice; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000033:anatomy & histology* / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D010507:Periodicity; D014157:Transcription Factors / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; C500943:Atoh1 protein, mouse; C109220:NBPhox protein