Parallel solution-phase synthesis of a 2-aminothiazole library including fully automated work-up.
A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.
MS-DTC-M Med Chem Darmstadt 1B1, Merck Serono, Merck KGaA, Frankfurter Strasse 250, D-64293, Darmstadt, Germany. Hans-Peter.Buchstaller@merck.de
Hans-Peter
HP
Buchstaller
Uwe
U
Anlauf
D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D054852:Small Molecule Libraries; D013844:Thiazoles; C004483:2-aminothiazole