HLA-DPB1 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in southern Han Chinese.
OBJECTIVE
To analyze the role of HLA-DRB1 and -DPB1 alleles in the pathogenesis of neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese.


METHODS
Thirty serum anti-aquaporin 4 antibodies (AQP4-Ab)-positive NMO patients, 53 conventional multiple sclerosis (C-MS) patients, and 93 controls (CTLs) were enrolled. The HLA-DRB1 and -DPB1 alleles of the subjects were determined by sequencing-based typing (SBT).


RESULTS
The frequency of the DRB1 0901 was lower in NMO patients than in CTLs (P(uncorr)=0.022, OR: 0.194, 95% CI: 0.043-0.876), and DRB1 1602 was higher in NMO patients than in C-MS (P(uncorr)=0.038, OR: 3.491, 95% CI: 1.024-11.896) and CTLs (P(uncorr)=0.051, OR: 2.711, 95% CI: 0.971-7.556). The frequency of DPB1 0501 was significant higher in NMO patients than in C-MS (P(uncorr)=0.018, OR: 4.629, 95% CI: 1.235-17.350) and CTLs (P(uncorr)=0.001, P(corr)=0.022, OR: 7.096, 95% CI: 2.011-25.044).


CONCLUSIONS
DPB1 0501 correlates with risk of AQP4-Ab positive NMO in Southern Han Chinese.
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun yat-sen University, Guangzhou, Guangdong Province, China.
Honghao
H
Wang
Yongqiang
Y
Dai
Wei
W
Qiu
Xiaonan
X
Zhong
Aimin
A
Wu
Yuge
Y
Wang
Zhengqi
Z
Lu
Jian
J
Bao
Xueqiang
X
Hu
D000328:Adult; D051401:Aquaporin 4 / Q000276:immunology*; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D001483:Base Sequence; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D008297:Male; D009471:Neuromyelitis Optica / Q000208:ethnology / Q000235:genetics* / Q000276:immunology*
C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C538744:HLA-DPB1*05:01 antigen