Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization.
Bisphenol A (BPA) is an endocrine disruptor with estrogenic properties that can adversely affect meiotic spindle assemblies. Our data indicate that BPA exposure in female patients may interfere with oocyte quality during IVF, as suggested by the inverse association between serum unconjugated BPA concentration and normal fertilization.
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94115-0916, USA. fujimotov@obgyn.ucsf.edu
Victor Y
VY
Fujimoto
Dongsul
D
Kim
Frederick S
FS
vom Saal
Julie D
JD
Lamb
Julia A
JA
Taylor
Michael S
MS
Bloom
D000328:Adult; D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors / Q000032:analysis / Q000097:blood / Q000633:toxicity; D005260:Female; D005306:Fertilization / Q000187:drug effects / Q000502:physiology; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy; D008297:Male; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects*; D009994:Osmolar Concentration; D010062:Ovulation Induction / Q000379:methods; D010636:Phenols / Q000032:analysis / Q000097:blood* / Q000633:toxicity*; D011247:Pregnancy; D011786:Quality Control; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds