Enantioselective α- and γ-alkylation of α,β-unsaturated aldehydes using dienamine activation.
The enantioselective alkylation of α,β-unsaturated aldehydes with stabilized carbocations as electrophiles via the activation as dienamine intermediates is described. This unique application of dienamine catalysis allows for the first enantioselective γ-alkylation of linear α,β-unsubstituted enals.
Faculty of Chemistry, TU Dortmund University, Otto-Hahn-Str. 6, 44227 Dortmund, Germany.
Julian
J
Stiller
Eugenia
E
Marqués-López
Raquel P
RP
Herrera
Roland
R
Fröhlich
Carsten
C
Strohmann
Mathias
M
Christmann