[Control of bone remodeling by nervous system. Effect of antipsychotics, antidepressants and β-blockers on bone metabolism].
Most antipsychotics cause hypogonadism due to hyperprolactinemia. And selective serotonin reuptake inhibitors, the first-line antidepressants, have been reported to accelerate bone loss. These drugs, as well as tricyclic antidepressants, also increase falls, leading to a high fracture risk. Clinical data suggest that β-adrenergic receptor antagonists prevent bone loss and fractures, but it still remains controversial. This overview summarizes recent clinical findings about effect of these modulators of psychotic and neural function on bone metabolism.
Third Department of Medicine, Teikyo University Chiba Medical Center, Teikyo, Japan.
Daisuke
D
Inoue
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced; D007006:Hypogonadism / Q000139:chemically induced; D010024:Osteoporosis / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects
D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D017367:Selective Serotonin Reuptake Inhibitors