Duloxetine treatment of long-term ketamine abuse-related lower urinary tract symptoms: a case report.
OBJECTIVE
To report a case of ketamine abuse-related lower urinary tract symptoms (LUTS) in a depressed patient, who was successfully treated with duloxetine.


METHODS
A 19-year-old woman with long-term (3 years) daily ketamine abuse had developed moderate depressive symptoms after forced cessation of ketamine use, together with severe LUTS of 3 months' duration. Urinary analysis and culture revealed negative results, and treatment with antibiotics was unsuccessful. Ketamine abuse-related LUTS were suspected and duloxetine was prescribed at 60 mg daily. After 2 weeks, the symptoms of depression and LUTS had been relieved.


CONCLUSIONS
Duloxetine can be considered as one of the therapeutic drugs of choice for depressive patients with significant LUTS.
Department of Psychiatry, Taichung Armed Forces General Hospital, Taiping City, Taiwan, Republic of China.
Jia-Yu
JY
Chao
Hwa-An
HA
Shai
D000778:Anesthetics, Dissociative / Q000009:adverse effects; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D007649:Ketamine / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D013876:Thiophenes / Q000627:therapeutic use*; D014549:Urinary Incontinence / Q000139:chemically induced / Q000175:diagnosis / Q000534:rehabilitation; D014555:Urination Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000534:rehabilitation; D014563:Urodynamics / Q000187:drug effects; D055815:Young Adult
D000778:Anesthetics, Dissociative; D000928:Antidepressive Agents; D013876:Thiophenes; D007649:Ketamine; D000068736:Duloxetine Hydrochloride