4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization.
There is a high demand for tumor specific PET tracers in oncology imaging. Besides glucose, certain amino acids also serve as energy sources and anabolic precursors for tumors. Therefore, (18)F-labeled amino acids are interesting probes for tumor specific PET imaging. As glutamine and glutamate play a key role in the adapted intermediary metabolism of tumors, the radiosynthesis of 4-[(18)F]fluoro l-glutamic acid (BAY 85-8050) as a new specific PET tracer was established. Cell-uptake studies revealed specific tumor cell accumulation.
Institute of Human Brain of the Russian Academy of Science, St. Petersburg, Russia.
Raisa N
RN
Krasikova
Olga F
OF
Kuznetsova
Olga S
OS
Fedorova
Yuri N
YN
Belokon
Viktor I
VI
Maleev
Linjing
L
Mu
Simon
S
Ametamey
P August
PA
Schubiger
Matthias
M
Friebe
Mathias
M
Berndt
Norman
N
Koglin
Andre
A
Mueller
Keith
K
Graham
Lutz
L
Lehmann
Ludger M
LM
Dinkelborg
D045744:Cell Line, Tumor; D005462:Fluorine Radioisotopes; D005971:Glutamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007553:Isotope Labeling; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism
D005462:Fluorine Radioisotopes; D005971:Glutamates; D019275:Radiopharmaceuticals; C038473:4-fluoroglutamic acid