Effects of selective anxiolytic afobazole on active caspase-3.
We studied the effects of afobazole on apoptosis through active caspase-3. Afobazole in a final concentration of 10(-8) M inhibits hyperactivation of effector apoptotic caspase-3 in HT-22 cell culture under conditions of glutamate toxicity.
Laboratory of Pharmacology of Neuroprotection, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Russia. niipharm@mail.ru
T A
TA
Antipova
D S
DS
Sapozhnikova
M Yu
MY
Stepanichev
M V
MV
Onufriev
N V
NV
Gulyaeva
S B
SB
Seredenin
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001562:Benzimidazoles / Q000494:pharmacology*; D006690:Bisbenzimidazole; D053148:Caspase 3 / Q000378:metabolism*; D002460:Cell Line; D018698:Glutamic Acid / Q000378:metabolism* / Q000633:toxicity; D051379:Mice; D008856:Microscopy, Fluorescence; D009025:Morpholines / Q000494:pharmacology*; D017830:Octoxynol
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines; D018698:Glutamic Acid; D017830:Octoxynol; D053148:Caspase 3; D006690:Bisbenzimidazole