Synthesis and antidepressant-like action of 9-alkoxy-7H-furo[3,2-g] chromen-7-ones in mice.
The present study describes the chemical synthesis and pharmacological evaluation of a series of 9-alkoxy-7H-furo[3,2-g]-chromen-7-ones. The pharmacological results of these compounds show that nine of them, given orally, reduced the immobility time in the forced swimming test. The results of the open-field test further confirmed that these compounds possessed an antidepressant-like effect. In the 5-hydroxytryptophan induced head-twitch test, 9-(3-chlorobenzyloxy)-7H-furo[3,2-g]chromen-7-one (3 m, 40 mg/kg p. o.) significantly increased the cumulative numberof head twitches. This finding suggested that the antidepressant-like profile seems to involve the serotonergic system as underlying mechanism.
College of Pharmacy, Yanbian University, Yanji, Jilin, P.R. China.
Xian-Qing
XQ
Deng
Cheng-Xi
CX
Wei
Ming-Xia
MX
Song
Zhe-Shan
ZS
Quan
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000633:toxicity; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism; D004357:Drug Synergism; D011564:Furocoumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013329:Structure-Activity Relationship; D013550:Swimming / Q000523:psychology; D015016:Yohimbine / Q000633:toxicity
D000317:Adrenergic alpha-Antagonists; D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D011564:Furocoumarins; D015016:Yohimbine; D006916:5-Hydroxytryptophan