[The expressions of STAT3, WWOX and c-myc in human non small cell lung cancer tissue and correlativity analysis].
OBJECTIVE
To investigate the expression of STAT3, WWOX and c-myc in non small cell lung cancer(NSCLC) and their clinical significance, and study their relation ship.


METHODS
Forty resected tissue samples from patients with NSCLC and twenty normal lung tissues were subjected to immunohistochemical staining(SP) for STAT3, WWOX and c-myc.


RESULTS
(1)The positive expression rate of STAT3 and c-myc in NSCLC were 92.5% and 90% respectively, obviously higher than normal lung tissues (20% and 15%, P<0.01); The positive expression rate of WWOX was 30%, apparently lower than normal lung tissues(75%, P<0.01). (2) The expression levels of STAT3 and c-myc were related to pathologic types in NSCLC, which in adenocarcinomas were higher than squmous cell carcinomas (P<0.01), which were regardless with tumor size, histodifferentiation level, clinical stage and lymphatic metastasis; The expression of WWOX was ralated to whether lymph node metastasis in NSCLC(P<0.01).(3) There was a negativie correlation between the expressions of STAT3 and WWOX (r=-0.443, P<0.01); But no relationship was found between STAT3 and c-myc overexpression(r=-0.084) and between WWOX and c-myc overexpression(r=0.115).


CONCLUSIONS
STAT3 and c-myc were overexpressed in human NSCLC. It indicated these proteins may make an important role in occurrence and development of lung cancer.The expressions of WWOX in human NSCLC was lower, which non expression was may related to the invision and metastasis of tumor. In the tumorigenesis of NSCLC, there is no relationship between expression of STAT3 and c-myc, They played independent roles in oncogenesis of NSCLC. There was a negativie correlation between the expressions of STAT3 and WWOX, but no relationship was found between WWOX and c-myc.
Department of Respiratory Medicine, the First Peopel's Hospital of Tianmen, Tianmen 431700, China. hying609@163.com
Fu-Ying
FY
Hu
Le-Peng
LP
Wang
Li-Li
LL
Hou
Gang
G
Yin
Hong-Cheng
HC
Wang
D000328:Adult; D000368:Aged; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010088:Oxidoreductases / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D000074584:WW Domain-Containing Oxidoreductase
C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D050796:STAT3 Transcription Factor; D025521:Tumor Suppressor Proteins; D010088:Oxidoreductases; D000074584:WW Domain-Containing Oxidoreductase; C486071:WWOX protein, human