Coping with DNA double strand breaks.
The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin.
Biomedical Research Institute & Dundee Cancer Centre, Ninewells Hospital & Medical School, Dundee DD1 9SY, Scotland, UK. k.hiom@dundee.ac.uk
Kevin
K
Hiom
D002453:Cell Cycle / Q000502:physiology*; D002843:Chromatin / Q000235:genetics / Q000502:physiology*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics / Q000502:physiology*; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D011995:Recombination, Genetic / Q000235:genetics / Q000502:physiology*
D002843:Chromatin