Imaging the elastic properties of tissue: the 20 year perspective.
After 20 years of innovation in techniques that specifically image the biomechanical properties of tissue, the evolution of elastographic imaging can be viewed from its infancy, through a proliferation of approaches to the problem to incorporation on research and then clinical imaging platforms. Ultimately this activity has culminated in clinical trials and improved care for patients. This remarkable progression represents a leading example of translational research that begins with fundamentals of science and engineering and progresses to needed improvements in diagnostic and monitoring capabilities applied to major categories of disease, surgery and interventional procedures. This review summarizes the fundamental principles, the timeline of developments in major categories of elastographic imaging, and concludes with recent results from clinical trials and forward-looking issues.
Department of Electrical and Computer Engineering, University of Rochester, Hopeman Engineering Building, Box 270126, Rochester, NY 14627, USA. parker@seas.rochester.edu
K J
KJ
Parker
M M
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Doyley
D J
DJ
Rubens
D002986:Clinical Trials as Topic; D055119:Elastic Modulus; D004547:Elastic Tissue / Q000000981:diagnostic imaging* / Q000473:pathology / Q000502:physiology; D054459:Elasticity Imaging Techniques / Q000266:history / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011859:Radiography