[Stage 1 testicular seminoma].
Testicular cancer is rare, representing only 1 % of malignant tumors, but the most common cancer in young men, 15 to 35 years. Adjuvant radiotherapy after orchidectomy in testicular seminoma stage I, reduces risk of relapse. It aims to eradicate micro-metastatic disease in lymph drainage territories. In the case of adjuvant radiotherapy, the relapse-free survival of 96 % with an overall survival of 98 % at 5 years. The irradiation volume is made up of lymph nodes paraaortic which it is possible to add the ipsilateral renal hilum to the testicular lesion. The current recommended dose is 20 Gy in 10 fractions and 2 weeks, usually delivered by two antero-posterior beams. The acute toxicities, mainly represented by nausea and diarrhea are usually quickly resolved to the end of irradiation. Regarding toxicities long-term, preservation of semen should be considered after surgery because of fear of infertility post-treatment. The risk of second cancer associated with exposure to ionizing radiation, albeit small, is especially important to consider these patients to significant life expectancy. Nevertheless, developments in radiotherapy techniques and lower doses and irradiated volumes can probably reduce this risk further.
Département de radiothérapie, hôpital de la Timone, 264, rue Saint-Pierre, 13005 Marseille, France. manugross@free.fr
E
E
Gross
C
C
Champetier
Y
Y
Pointreau
A
A
Zaccariotto
T
T
Dubergé
B
B
Chauvet
D000293:Adolescent; D000328:Adult; D003967:Diarrhea / Q000000981:diagnostic imaging; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D006801:Humans; D015994:Incidence; D008198:Lymph Nodes / Q000469:parasitology / Q000528:radiation effects; D008297:Male; D009325:Nausea / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D018239:Seminoma / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D013736:Testicular Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D055815:Young Adult