Liver proteins as sensor of human malignancies and inflammation.
In this review we would like to highlight the importance of acute-phase proteins as sensor of diseases. Both acute-phase protein levels and glycosylation have been reported to be altered in inflammation and other diseases including cancer. Factors that promote acute-phase protein synthesis and enhance the expression of specific glycosyltransferases, such as sialyltransferases and fucosyltransferases, may be up-regulated in some tumours and would explain the changes in acute-phase protein levels and the specific N-glycosylation modifications of some acute-phase proteins in cancer. However, further studies are required to define the potential clinical application of these acute-phase protein cancer-specific modifications as possible cancer diagnostic or monitoring tools.
Unitat de Bioquímica i Biologia Molecular, Departament de Biologia, Universitat de Girona, Campus de Montilivi, Girona, Spain.
Rosa
R
Peracaula
Ariadna
A
Sarrats
Pauline M
PM
Rudd
D000209:Acute-Phase Proteins / Q000032:analysis*; D015415:Biomarkers / Q000097:blood*; D006801:Humans; D007249:Inflammation; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology*
D000209:Acute-Phase Proteins; D015415:Biomarkers