Synthesis, structure and biological evaluation of bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(iii) triphenylphosphine.
Bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(iii) triphenylphosphine [Ru(Sal-etsc)(H-Sal-etsc)(PPh(3))] was synthesized and structurally characterized by spectral and X-ray crystallographic studies and it showed 100% inhibition on the DPPH radical. It also exhibited a significant lymphocyte activity and inhibitory effect on the lung carcinoma A549 cell.
Department of Chemistry, Bharathiar University, Coimbatore, 641 046, India. rpnchemist@gmail.com
R
R
Prabhakaran
P
P
Kalaivani
R
R
Jayakumar
M
M
Zeller
A D
AD
Hunter
S V
SV
Renukadevi
E
E
Ramachandran
K
K
Natarajan
D000447:Aldehydes / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005562:Formazans; D006801:Humans; D006860:Hydrogen Bonding; D008214:Lymphocytes; D008940:Mitotic Index; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis; D013778:Tetrazolium Salts; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology
D000447:Aldehydes; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D005562:Formazans; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D013778:Tetrazolium Salts; D013882:Thiosemicarbazones; C557972:bis salicylaldehyde-4(N)-ethylthiosemicarbazone ruthenium(III) triphenylphosphine; C079782:MTT formazan; C061896:triphenylphosphine; C062542:salicylaldehyde thiosemicarbazone; D012428:Ruthenium