Increased risk of lymphoid neoplasm in patients with myeloproliferative neoplasm: a study of 1,915 patients.
Within a cohort of 1,915 consecutive patients with myeloproliferative neoplasm followed for a median time of 5.2 years (range 0-33.3), we investigated the occurrence of lymphoid neoplasm with the aim of defining this risk and to investigate the role of genetic predisposing factors. We identified 22 patients with myeloproliferative neoplasm who developed lymphoid neoplasm over their lifetime. We found that the risk of developing lymphoid neoplasm was 2.79-fold higher (95% CI, 1.80-4.33; P<0.001) than that of the general Italian population. A tag SNP surrogate for JAK2 GGCC haplotype was used to clarify a potential correlation between lymphoid-myeloid neoplasm occurrence and this genetic predisposing factor. As we did not find any difference in GGCC haplotype frequency between patients with both myeloid and lymphoid neoplasm and patients with myeloid neoplasm, JAK2 GGCC haplotype should not be considered a genetic predisposing factor. No difference in familial clustering was observed between the two groups.
Division of Hematology, Department of Hematology Oncology, University of Pavia Medical School and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Elisa
E
Rumi
Francesco
F
Passamonti
Chiara
C
Elena
Daniela
D
Pietra
Luca
L
Arcaini
Cesare
C
Astori
Silvia
S
Zibellini
Emanuela
E
Boveri
Cristiana
C
Pascutto
Mario
M
Lazzarino
D016000:Cluster Analysis; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006239:Haplotypes; D006801:Humans; D007558:Italy; D053614:Janus Kinase 2 / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000201:enzymology / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008223:Lymphoma / Q000201:enzymology / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000150:complications / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D053614:Janus Kinase 2