Efficacy of three surface disinfectants against spores of Clostridium difficile ribotype 027.
BACKGROUND
The emergence of Clostridium difficile ribotype 027 raised the question of sporicidal surface disinfectants are also effective against spores of C. difficile ribotype 027.


METHODS
Three surface disinfectants based on magnesium monoperoxyphthalate hexahydrate (Dismozon pur), a combination of (ethylenedioxy)dimethanol, glutaral and benzyl-C12-18-alkyldimethylammonium chlorides (Kohrsolin extra) and a combination of glutaral, benzyl-C12-18-alkyldimethylammonium chlorides and didecyl-dimethylammonium chloride (Kohrsolin FF) were tested in a suspension test in various concentrations and contact times against spores of three C. difficile strains including ribotype 027.


RESULTS
All three surface disinfectant reduced the number of spores by ≥4 log(10) steps, e.g. Dismozon pur at 1.5% and 2 h exposure time, Kohrsolin extra at 2% and 4 h exposure time, and Kohrsolin FF at 2% and 6 h exposure time. Spores of ribotype 027 did not show a lower susceptibility to Dismozon pur compared to the other two C. difficile strains.


CONCLUSIONS
All three tested surface disinfectants should be effective for surface disinfection in outbreaks caused by C. difficile ribotype 027.
Commonwealth Biotechnologies Inc., 601 Biotech Drive, Richmond, VA 23235, USA.
Douglas
D
Horejsh
Günter
G
Kampf
D016360:Clostridioides difficile / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D004203:Disinfection / Q000379:methods*; D010795:Phthalic Acids / Q000494:pharmacology; D021521:Ribotyping; D013171:Spores, Bacterial / Q000187:drug effects*
D004202:Disinfectants; D010795:Phthalic Acids; C044731:magnesium monoperoxyphthalate