Mixed micelles of amphiphilic drug promethazine hydrochloride and surfactants (conventional and gemini) at 293.15K to 308.15K: Composition, interaction and stability of the aggregates.
Micellization of an amphiphilic phenothiazine drug promethazine hydrochloride (PMT) in presence of conventional (CTAB and TTAB) as well as gemini (16-s-16 and 14-s-14, s=4-6) cationic surfactants has been studied conductometrically at different temperatures. Critical micelle concentration values (cmc and cmc(id)) indicate mixed micelle formation among the two components. Micellar mole fractions of surfactants (X(1), X(1)(M) and X(1)(id)) show greater contribution of surfactants. Interaction parameter, β, suggests attractive interactions in the mixed systems. The thermodynamic parameters suggest dehydration of hydrophobic part of the drug at higher temperatures.
Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India. kabir7@rediffmail.com
Kabir-Ud-Din
Malik Abdul
MA
Rub
Andleeb Z
AZ
Naqvi
D018926:Anti-Allergic Agents / Q000737:chemistry*; D004355:Drug Stability; D008823:Micelles; D011398:Promethazine / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics
D018926:Anti-Allergic Agents; D008823:Micelles; D013501:Surface-Active Agents; D011398:Promethazine