Serum paraoxonase and arylesterase activities in patients with pulmonary tuberculosis.
BACKGROUND
The aim of the present study was to determine serum paraoxonase and arylesterase activities in tuberculosis, nontuberculosis pulmonary disease and healthy subjects.


METHODS
In this case-control study we determined the serum paraoxonase and arylesterase activities in 36 patients with pulmonary tuberculosis, 38 nontuberculosis pulmonary disease and 49 healthy controls.


RESULTS
The results showed that serum paraoxonase (PON) activity was significantly lower in patients with pulmonary tuberculosis (61.10±51.62IU/L) than healthy controls (98.79±68.79IU/L) (p<0.05). In addition we found that the level of PON activity was significantly lower in patients with nontuberculosis pulmonary disease (67.49±47.88IU/L) than normal individuals (p<0.05). There was no significant differences regarding PON activity between patients with pulmonary tuberculosis and nontuberculosis pulmonary disease (p>0.05). The arylesterase activity was significantly lower in patients with pulmonary tuberculosis than nontuberculosis pulmonary disease and normal subjects (p<0.05).


CONCLUSIONS
The lower paraoxonase and aryesterase activities in pulmonary tuberculosis patients compared to healthy subjects might be due to imbalance of oxidant/antioxidant systems in pulmonary tuberculosis patients which needs more clarification.
Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mohamamd
M
Naderi
Mohammad
M
Hashemi
Fatemeh
F
Komijani-Bozchaloei
Abdolkarim
A
Moazeni-Roodi
Mohammadamin
M
Momenimoghaddam