[Early biological markers of manganese exposure].
OBJECTIVE
To explore the biomarker of manganese exposure by analyzing the relationship between manganese exposure and concentration in some biomaterials.


METHODS
The air samples were collected through the individual air sample. According to the manganese levels in the air, workers were assigned to control group, low concentration group and high concentration group, and manganese in the hair, urine, serum, blood cell and saliva from different group were measured respectively. The correlations between concentration of external manganese exposure and manganese concentrations in biomaterials, and years of employment and concentrations in biomaterials were analyzed.


RESULTS
In the high concentration group, saliva manganese was 32.17 µg/L, hair manganese was 37.39 mg/kg, urine manganese was 2.50 µg/L, plasma manganese was 29.61 µg/L, blood manganese was 14.49 µg/L, were higher than those in the control group (10.40 µg/L, 1.60 mg/kg, 0.77 µg/L, 10.30 µg/L, 4.56 µg/L respectively) (P < 0.01). The manganese concentration in the saliva was significantly correlated with airborne manganese concentration (r = 0.649, P < 0.01), with the years of employment (r = 0.404, P < 0.01), with the total exposure of manganese (r = 0.342, P < 0.01), with the manganese concentration of plasma (r = 0.303, P < 0.01) and with the manganese concentration in blood cells (r = 0.359, P < 0.01), respectively.


CONCLUSIONS
The concentration of manganese in saliva could work as a biomarker of manganese internal exposure.
Department of Preventive Medicine, Zunyi Medical College, Zunyi, Guizhou Province 563000, China.
Yuan-zhong
YZ
Zhou
Jian
J
Chen
Xiu-juan
XJ
Shi
Yan
Y
Zou
Xu-bo
XB
Shen
Wei
W
Zheng
Chang-yin
CY
Yu
Qi-yuan
QY
Fan
D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D006197:Hair / Q000737:chemistry; D006801:Humans; D008345:Manganese / Q000032:analysis* / Q000097:blood / Q000652:urine; D020149:Manganese Poisoning / Q000517:prevention & control; D008875:Middle Aged; D016273:Occupational Exposure / Q000517:prevention & control*; D012463:Saliva / Q000737:chemistry*; D055815:Young Adult
D000395:Air Pollutants, Occupational; D015415:Biomarkers; D008345:Manganese