Bcl-2 targeted-therapy for the treatment of head and neck squamous cell carcinoma.
Despite recent advances in treatment of head and neck cancer, survival has not improved as expected. Bcl-2 family proteins play important role in regulating apoptosis. Recently, newer molecules have been developed for inhibition of Bcl-2 related proteins. We, herein aim to discuss the importance of Bcl-2 family proteins to the development of head and neck cancer and how the targeted-therapy for inhibition of Bcl-2 and related proteins, based on new drugs and recent patents, could improve the efficacy of the systemic therapy.
Medical Oncology Department, Barretos Cancer Hospital, Barretos -SP, 14784-400, Brazil.
Lucas V
LV
dos Santos
André L
AL
Carvalho
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D002277:Carcinoma / Q000188:drug therapy / Q000235:genetics; D002294:Carcinoma, Squamous Cell; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods*; D018307:Neoplasms, Squamous Cell / Q000188:drug therapy / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors* / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D000077195:Squamous Cell Carcinoma of Head and Neck
D000970:Antineoplastic Agents; D019253:Proto-Oncogene Proteins c-bcl-2