Dicarbonyl-bis(cysteamine)iron(II): a light induced carbon monoxide releasing molecule based on iron (CORM-S1).
Carbon monoxide releasing molecules (CORMs) deliver controlled amounts of CO to biological targets and organs. The reaction of cysteamine with triirondodecacarbonyl yields dicarbonyl bis(aminoethylthiolato)iron(II) that represents an iron-based CORM with biogenic ligands. X-ray diffraction studies at a single crystal show a cis-arrangement of the carbonyl ligands in trans-position to the amino groups with average Fe-C and C-O distances of 176.8 and 114.8 pm. The CO release is mediated by irradiation with visible light (λ>400 nm). Physiological tests using ion channels sensitive to CO revealed the light- and time-dependent decomposition of CORM-S1 without obvious adverse effects on the cellular level. CORM-S1 is thus suitable for selective CO release and possesses a high potential for therapeutic application.
Institute of Inorganic and Analytical Chemistry, Friedrich Schiller University of Jena, Germany.
Robert
R
Kretschmer
Guido
G
Gessner
Helmar
H
Görls
Stefan H
SH
Heinemann
Matthias
M
Westerhausen
D002248:Carbon Monoxide / Q000737:chemistry*; D058085:Iron Compounds / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
D058085:Iron Compounds; D009942:Organometallic Compounds; D002248:Carbon Monoxide