Total synthesis of (+)-nafuredin-γ using a highly stereoselective Ti-mediated aldol reaction.
An efficient total synthesis of (+)-nafuredin-γ has been achieved in 10 steps from (E)-3-(tributylstannyl)propenal. The synthesis features direct construction of an anti-1,2-diol moiety via a Ti-mediated aldol reaction of lactyl derivative and rapid fragment assembly, which relied on well-established Pd chemistry.
Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI), 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan.
Yuta
Y
Onodera
Takahiro
T
Suzuki
Susumu
S
Kobayashi
D015394:Molecular Structure; D011753:Pyrones / Q000138:chemical synthesis*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D011753:Pyrones; C423563:nafuredin; D014025:Titanium