Synthesis of difluoroaryldioxoles using BrF3.
A novel synthesis of different aromatic and heteroaromatic difluorodioxole derivatives has been developed. The starting materials were catechols, which, after treatment with thiophosgene, formed at 0 °C the respective thiodioxoles. The latter were reacted for a short time with commercially available bromine trifluoride, producing potentially biologically important difluoroaryldioxoles in moderate to high yields.
School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.
Youlia
Y
Hagooly
Michael J
MJ
Welch
Shlomo
S
Rozen
D017605:Bromine Compounds / Q000737:chemistry*; D017611:Fluorine Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*
D017605:Bromine Compounds; D017611:Fluorine Compounds; C507211:bromine trifluoride; D010100:Oxygen