Effects of levofloxacin, moxifloxacin and prulifloxacin on murine gut colonization by Candida albicans.
Fluoroquinolones are broad-spectrum antibiotics increasingly utilized as empirical or prophylactic therapy in the management of cancer patients. We evaluated the effects of newer generation fluoroquinolones on the level of gastrointestinal (GI) colonization by Candida albicans in a previously established mouse model. Adult male Crl:CD1 (ICR) BR mice were fed chow containing Candida albicans or regular chow. The mice fed the Candida chow had their gut colonized by the yeast. Both groups were subsequently given levofloxacin, moxifloxacin, prulifloxacin or normal saline for 10 days. Stool cultures were performed immediately before, at the end, and one week after discontinuation of treatment to determine the level of intestinal yeast colonization. Candida-colonized mice treated with fluoroquinolones had substantially higher yeast counts in their stools than control mice fed Candida containing chow but treated with saline. Mice fed regular chow and treated with the study antibiotics or saline did not have any Candida in their stools. Dissemination of Candida to internal organs was not observed in any animal. In conclusion, we have shown that all fluoroquinolones tested induced substantial increases in the murine intestinal concentration of C. albicans.
Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece. sofiamaraki@in.gr
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Maraki
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Lionakis
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Ntaoukakis
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Barbounakis
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Ntasis
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Kofteridis
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Samonis
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001372:Aza Compounds / Q000008:administration & dosage*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D004148:Dioxolanes / Q000008:administration & dosage*; D005243:Feces / Q000382:microbiology; D024841:Fluoroquinolones / Q000008:administration & dosage*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D064704:Levofloxacin; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023421:Models, Animal; D000077266:Moxifloxacin; D015242:Ofloxacin / Q000008:administration & dosage*; D010879:Piperazines / Q000008:administration & dosage*; D011804:Quinolines / Q000008:administration & dosage*; D012965:Sodium Chloride
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D004148:Dioxolanes; D024841:Fluoroquinolones; D010879:Piperazines; D011804:Quinolines; D012965:Sodium Chloride; D064704:Levofloxacin; D015242:Ofloxacin; C074191:prulifloxacin; D000077266:Moxifloxacin