Clinical evidence of ozone interaction with pain mediators.
OBJECTIVE
To address the clinical evidence that may support the fact that subcutaneous administration of ozone (O₃) has anti-hyperalgesic effects probably acting by modifying specific pain targets.


METHODS
Fifty-two patients attending the Medinat Clinic, Camerano, Ancona, Italy between October 2004 to October 2009 were eligible to participate in the study. Panoramic photos of painful and not painful areas submitted to oxygen (O₂)/O₃ ozone treatment injection were analyzed to detect the intensity of erythema.


RESULTS
The erythematic areas after O₃ subcutaneous puncture showed significant (p<0.05) increment (83 ± 5%) in the painful area versus 7 ± 6% in the contralateral area.


CONCLUSIONS
The surrounding erythema observed during O₃ intervention should explain at least in part, its interaction with some pain mediators. This may involve algesic mediators or receptors. The analgesic mechanism induced by O₂/O₃ may involve 2 independent steps: a short-term mechanism that may correspond with the direct oxidation on biomolecules, and a long-term mechanism that may involve the activation of antioxidant pathways. Further studies are needed to support the biochemical analgesic mechanism of O₃ therapy.
University of Ancona, Italy. lambertore@univpm.it
Lamberto
L
Re
Gregorio M
GM
Sanchez
Nabil
N
Mawsouf
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D011446:Prospective Studies; D055815:Young Adult
D010126:Ozone