A cationic Zn(II) porphyrazine induces a stable parallel G-quadruplex conformation in human telomeric DNA.
A water soluble Zn(II) porphyrazine drives the conformational equilibrium of the G-quadruplex of a human telomeric sequence exclusively towards a parallel conformation upon complexation.
Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, via Gobetti 101, 40129 Bologna, Italy.
Ilse
I
Manet
Francesco
F
Manoli
Maria Pia
MP
Donzello
Elisa
E
Viola
Giuseppina
G
Andreano
Annalisa
A
Masi
Luciano
L
Cellai
Sandra
S
Monti
D002412:Cations / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry*; D008958:Models, Molecular; D016615:Telomere / Q000737:chemistry*
D002412:Cations; D008665:Metalloporphyrins; C556632:tetrakis-2,3-(5,6-di(2-(N-methyl)pyridiniumyl)pyrazino)porphyrazinato-ZnII; D004247:DNA