Periodontal disease and perinatal outcomes.
OBJECTIVE
To elucidate plausible associations between periodontal disease (PD) and pregnancy events through meta-analysis of original research published between 1998 and 2010.


METHODS
One hundred and twenty-five randomized, case-control, matched-cohort studies on pregnancy and postpartum specifics in women with PD are identified through PubMed, LILACS, and Cochrane Register. Meta-study is performed on a sample of 992 births allocated from studies of level I-II-1 evidence. An oral inflammation score (OIS) is composed from parameteric and observational components of maternal PD. Pearson arrival process is modeled for exchangeable correlations.


RESULTS
Women with preeclampsia and preterm birth have poor periodontal parameters in both, treatment and placebo groups (OR 1.94-2.9). In puerperae with severe periodontitis birth weight is negatively correlated with maternal probing depth (r = -0.368), and C-reactive protein (r = -0.416). Higher rates of tobacco use (RR 3.02), bacterial vaginosis (RR 2.7), clinical attachment level (OR 2.76), and fetal tyrosine kinase (OR 1.6) contribute in increased rates of preeclamsia (RR 1.68), and prematurity (RR 2.75). After adding confounders into the model OIS remains significantly associated with preterm birth (OR 2.3).


CONCLUSIONS
Maternal PD has strong associations with preeclampsia and prematurity.
Open Medical Institute, Salzburg, Austria. nmatevo@emory.edu
Naira Roland
NR
Matevosyan
D003729:Dental Care; D005260:Female; D006801:Humans; D010510:Periodontal Diseases / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology