CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.
The causes of age-related macular degeneration (AMD) are not well understood. Due to demographic shifts in the industrialized world a growing number of people will develop AMD in the coming decades. To develop treatments it is essential to characterize the disease's pathogenic process. Over the past few years, numerous studies have focused on the role of chemotactic cytokines, also known as chemokines. Certain chemokines, such as CCL2 and CX3CL1, appear to be crucial in subretinal microglia and macrophage accumulation observed in AMD, and participate in the development of retinal degeneration as well as in choroidal neovascularization. This paper reviews the possible implications of CCL2 and CX3CL1 signaling in AMD. Expression patterns, single nucleotide polymorphisms (SNPs) association studies, chemokine and chemokine receptor knockout models are discussed. Future AMD treatments could target chemokines and/or their receptors.
INSERM, UMR S, Centre de Recherche des Cordeliers, Paris, France.
William
W
Raoul
Constance
C
Auvynet
Serge
S
Camelo
Xavier
X
Guillonneau
Charles
C
Feumi
Christophe
C
Combadière
Florian
F
Sennlaub
D000818:Animals; D000073883:CX3C Chemokine Receptor 1; D018932:Chemokine CCL2 / Q000235:genetics / Q000276:immunology*; D054428:Chemokine CX3CL1 / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D008268:Macular Degeneration / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D020641:Polymorphism, Single Nucleotide; D054390:Receptors, CCR2 / Q000235:genetics / Q000276:immunology*; D019707:Receptors, Chemokine / Q000235:genetics / Q000276:immunology; D012160:Retina / Q000166:cytology / Q000276:immunology; D015398:Signal Transduction / Q000502:physiology
D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D018932:Chemokine CCL2; D054428:Chemokine CX3CL1; D054390:Receptors, CCR2; D019707:Receptors, Chemokine