FINDbase: a worldwide database for genetic variation allele frequencies updated.
Frequency of INherited Disorders database (FIND base; http://www.findbase.org) records frequencies of causative genetic variations worldwide. Database records include the population and ethnic group or geographical region, the disorder name and the related gene, accompanied by links to any related external resources and the genetic variation together with its frequency in that population. In addition to the regular data content updates, we report the following significant advances: (i) the systematic collection and thorough documentation of population/ethnic group-specific pharmacogenomic markers allele frequencies for 144 markers in 14 genes of pharmacogenomic interest from different classes of drug-metabolizing enzymes and transporters, representing 150 populations and ethnic groups worldwide; (ii) the development of new data querying and visualization tools in the expanded FINDbase data collection, built around Microsoft's PivotViewer software (http://www.getpivot.com), based on Microsoft Silverlight technology (http://www.silverlight.net) that facilitates querying of large data sets and visualizing the results; and (iii) the establishment of the first database journal, by affiliating FINDbase with Human Genomics and Proteomics, a new open-access scientific journal, which would serve as a prime example of a non-profit model for sustainable database funding.
Department of Pharmacy, School of Health Sciences, Faculty of Engineering, University of Patras, Patras, Greece.
Marianthi
M
Georgitsi
Emmanouil
E
Viennas
Dimitris I
DI
Antoniou
Vassiliki
V
Gkantouna
Sjozef
S
van Baal
Emanuel F
EF
Petricoin
Konstantinos
K
Poulas
Giannis
G
Tzimas
George P
GP
Patrinos
D030561:Databases, Nucleic Acid; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000235:genetics; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D010506:Periodicals as Topic; D010597:Pharmacogenetics; D012984:Software
D005819:Genetic Markers