Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury.
More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets.
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Peng-fei
PF
WU
Zui
Z
ZHANG
Fang
F
WANG
Jian-guo
JG
CHEN
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D008519:Medicine, Traditional; D018696:Neuroprotective Agents / Q000737:chemistry / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D015427:Reperfusion Injury / Q000517:prevention & control*
D018696:Neuroprotective Agents; D010936:Plant Extracts