In vivo efficacy of griseofulvin against multiple myeloma.
We recently confirmed that ciclopirox olamine inhibits Wnt/beta catenin signalling in myeloma. Griseofulvin (GF) has similar chemical features as compared to ciclopirox olamine. In this study the anti-tumor effect of GF was investigated. GF demonstrated a major apoptotic activity in various human and murine myeloma and lymphoma cell lines as well as in human primary cells. In vivo, tumor growth as well as overall survival were significantly reduced in mice treated with GF as compared to untreated mice. In conclusion, our results reveal a significant selective induction of apoptosis by GF and suggest a significant in vivo effect against myeloma.
Department of Internal Medicine III, Center for Integrated Oncology, University of Bonn, Bonn, Germany.
Young
Y
Kim
Petra
P
Alpmann
Sabine
S
Blaum-Feder
Simon
S
Krämer
Tomoyuki
T
Endo
Desheng
D
Lu
Dennis
D
Carson
Ingo G H
IG
Schmidt-Wolf
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D000077768:Ciclopirox; D006118:Griseofulvin / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000077269:Lenalidomide; D008223:Lymphoma / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009101:Multiple Myeloma / Q000188:drug therapy*; D011728:Pyridones / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects*; D015996:Survival Rate; D013792:Thalidomide / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome; D051176:beta Catenin
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D011728:Pyridones; D051176:beta Catenin; D000077768:Ciclopirox; D006118:Griseofulvin; D013792:Thalidomide; D000077269:Lenalidomide