Are poor responders patients at higher risk for producing aneuploid embryos in vitro?
OBJECTIVE
To test the hypothesis that aged women with poor ovarian response express an increase on embryo chromosomal alterations when compared to aged women who presented normal response.


METHODS
Couples undergoing intracytoplasmic sperm injection cycles with preimplantation genetic screening, were subdivided into two groups: Poor Responder group (n = 34), patients who produced ≤4 oocytes; and Normoresponder group (n = 50), patients who produced ≥5 oocytes. Groups were compared regarding cycles' outcomes and aneuploidy frequency.


RESULTS
There were no significant differences between and groups regarding the fertilization rate (p = 0.6861), clinical pregnancy (p = 0.9208), implantation (p = 0.6863), miscarriage (p = 0.6788) and the percentage of aneuploid embryos (p = 0.270). Embryo transfer rate was significantly lower on poor responder group (p = 0.0128) and logistic regression confirmed the influence of poor response on the chance of embryo transfer (p = 0.016).


CONCLUSIONS
Aged females responding poorly to gonadotrophins are not at a higher risk for producing aneuploid embryos in vitro.
Sapientiae Institute - Educational and Research Center in Assisted Reproduction, Rua Vieira Maciel, 62, São Paulo, SP, Brazil.
Amanda Souza
AS
Setti
Daniela Paes
DP
de Almeida Ferreira Braga
Rita
R
de Cássia Savio Figueira
Matheus
M
de Castro Azevedo
Assumpto
A
Iaconelli
Edson
E
Borges
D000328:Adult; D000367:Age Factors; D000782:Aneuploidy; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009865:Oocytes / Q000166:cytology; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic