Classic and alternative complement cascades in post-traumatic stress disorder.
Hemolytic activity of classic and alternative complement cascades and blood concentrations of TNF-α, IL-1β, and IL-6 were measured in patients with post-traumatic stress disorder. The results attest to hyperactivity of the classic complement cascade associated with elevated content of proinflammatory cytokines and hypoactivation of the alternative complement cascade in patients with post-traumatic stress disorder in comparison with healthy individuals.
Institute of Molecular Biology, National Academy of Sciences of Armenia; Armenia StressCenter, Erevan, Armenia.
L P
LP
Oganesyan
G M
GM
Mkrtchyan
S H
SH
Sukiasyan
A S
AS
Boyajyan
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D013313:Stress Disorders, Post-Traumatic / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha