Effects of genetic variations in the dopaminergic system on fatigue in humans: gender aspects.
Changes in the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes. The volunteers (n=140) performed 3-h monotonous mental work (information processing and logical problem solving). The degree of fatigue was evaluated before and after exercise by the HAM (Health status-Activity-Moods) and AMF (Acute Mental Fatigue) questionnaires. A significant relationship between the DAT1, DRD2, and COMT gene polymorphism and changes in the mental sphere status were revealed. The effects of these polymorphisms were the most pronounced in girls. The results are discussed within the framework of hypothesis on the effects of changes in the phasic/tonic dopamine proportion on the studied functions.
Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. mal_nat@mail.ru
N V
NV
Malyuchenko
J V
JV
Schegolkova
M A
MA
Kulikova
M A
MA
Timofeeva
V A
VA
Shlepzova
O V
OV
Sysoeva
A M
AM
Ivanitsky
A G
AG
Tonevitsky
D002394:Catechol O-Methyltransferase / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D005222:Mental Fatigue / Q000235:genetics / Q000503:physiopathology*; D016133:Polymerase Chain Reaction; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012737:Sex Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
D017931:DNA Primers; D050483:Dopamine Plasma Membrane Transport Proteins; D017448:Receptors, Dopamine D2; C493214:SLC6A3 protein, human; D002394:Catechol O-Methyltransferase