[The role of the glutamatergic system in the pathogenesis and treatment of alcohol dependence].
The lack of satisfactory results of alcohol dependence treatment has necessitated the search for new directions of studies. One of them is connected with glutamatergic transmission. The influence of alcohol on this transmission is very complex and relates to changes including at the molecular level. However, the diversity of glutamatergic receptors creates a new possibility of modulation of its activity. It leads to decrease of alcohol reward abilities, prolongs abstinence time and reduces the incidence of acute alcohol intoxication in alcohol addicts. The use of acamprosate--a glutamatergic transmission modulator drug--and naltrexone (an opioid receptor antagonist) improves therapy effectiveness of acamprosate alone. Satisfactory results were achieved in the studies of topiramate--an antagonist of AMPA and KA receptors. Its effectiveness was proved in clinical studies. Topiramate reduced alcohol craving and prolonged abstinence time, which decreased the probability of relapse. There are promising preclinical results of groups I and II metabotropic receptor antagonists. However, further studies are necessary to elucidate precisely their role in alcohol dependence.
Zakład Farmakodynamiki Uniwersytetu Medycznego w Łodzi, Łódź.
Karina
K
Łukasik
Karolina
K
Piątkowska
Bogusława
B
Pietrzak
D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000437:Alcoholism / Q000503:physiopathology* / Q000628:therapy*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D017470:Receptors, Glutamate / Q000187:drug effects*; D016896:Treatment Outcome
D000427:Alcohol Deterrents; D018691:Excitatory Amino Acid Antagonists; D017470:Receptors, Glutamate