Novel H1N1 influenza A virus infection in a patient with acute rejection after liver transplantation.
BACKGROUND
The 2009 H1N1 influenza A virus was first identified in April 2009 and rapidly evolved into a pandemic. Recipients of solid-organ transplants have a higher risk for severe infection because of immunosuppression. There are limited reports of 2009 H1N1 influenza in liver transplant recipients, especially in China.


METHODS
We present a case of a 48-year-old male liver transplant recipient with 2009 H1N1 influenza A virus. He received therapy for acute rejection after transplantation and was confirmed with H1N1 virus infection.


RESULTS
The patient was started on oseltamivir (75 mg, orally twice daily) and had a benign hospital course, with defervescence and resolution of symptoms within 72 hours. The follow-up chest radiograph after discharge was normal.


CONCLUSIONS
The 2009 H1N1 influenza in this hospitalized transplant recipient was relatively mild, and prolonged viral shedding was not noted. Oseltamivir can be a valid measure in immunocompromised individuals.
Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Jiang-Juan
JJ
He
Sheng
S
Yan
Min
M
Zhang
Wei-Lin
WL
Wang
Shu-Sen
SS
Zheng
D000208:Acute Disease; D000998:Antiviral Agents / Q000627:therapeutic use; D006084:Graft Rejection / Q000150:complications*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications* / Q000188:drug therapy; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use
D000998:Antiviral Agents; D053139:Oseltamivir