Local drug delivery system for the treatment of osteomyelitis: In vitro evaluation.
Local antimicrobial delivery is a potential area of research conceptualized to provide alternative and better methods of treatment for cases, as osteomyelitis where avascular zones prevent the delivery of drugs from conventional routes of administration. Drug-loaded polymers and calcium phosphates as hydroxyapatites have been tried earlier. Bioactive glasses are bone-filling materials used for space management in orthopedic and dental surgery. A new bioactive glass (SSS2) was synthesized and fabricated into porous scaffold with a view to provide prolonged local delivery of gatifloxacin and fluconazole as suitable for the treatment of osteomyelitis. The new SSS2 was characterized by Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses. In addition, the bioactivity of the SSS2 glass and resulting scaffold was examined by in vitro acellular method and ascertained by FTIR and XRD. The pore size distribution was analysed by mercury intrusion porosimetry and the release of drugs from scaffolds were studied in vitro. The glass and the resulting scaffolds were bioactive indicating that they can bond with bone in vivo. The scaffolds were porous with pores predominantly in the range of 10-60 µm, released the drugs effectively for 6 weeks and deemed suitable for local delivery of drugs to treat osteomyelitis.
Central Glass & Ceramic Research Institute, Bioceramic and Coating Division, Raja S C Mallick Road, Kolkata, India.
Chidambaram
C
Soundrapandian
Debabrata
D
Basu
Biswanath
B
Sa
Someswar
S
Datta
D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004333:Drug Administration Routes; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D015725:Fluconazole / Q000737:chemistry; D024841:Fluoroquinolones / Q000737:chemistry; D000077734:Gatifloxacin; D005898:Glass / Q000737:chemistry*; D007700:Kinetics; D008422:Materials Testing / Q000379:methods; D010019:Osteomyelitis / Q000188:drug therapy; D017550:Spectroscopy, Fourier Transform Infrared; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
D000891:Anti-Infective Agents, Local; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D024841:Fluoroquinolones; D015725:Fluconazole; D000077734:Gatifloxacin