Non-invasive analysis of turbid samples using deep Raman spectroscopy.
Raman spectroscopy has recently seen major advances in the area of deep non-invasive characterisation of diffusely scattering samples; this progress is underpinned by the emergence of spatially offset Raman spectroscopy and associated renaissance of transmission Raman spectroscopy permitting the characterisation of diffusely scattering samples at depths not accessible by conventional Raman spectroscopy. Examples of emerging research activities include non-invasive diagnosis of bone disease and cancer, rapid quality control of pharmaceutical formulations and security screening of explosives and counterfeit drugs through unopened translucent bottles. This article reviews this field focusing on recent developments with high societal relevance.
Central Laser Facility, Research Complex at Harwell, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0QX, UK.
Kevin
K
Buckley
Pavel
P
Matousek
D000818:Animals; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D053834:Explosive Agents / Q000737:chemistry; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000295:instrumentation / Q000379:methods*
D053834:Explosive Agents; D004364:Pharmaceutical Preparations