PNAs grafted with (α/γ, R/S)-aminomethylene pendants: regio and stereo specific effects on DNA binding and improved cell uptake.
PNAs grafted with cationic aminomethylene (am) pendants on the backbone at the glycyl (α) or ethylenediamine (γ) segments show regio (α/γ) and stereochemistry (R/S) dependent binding with complementary DNA. These are efficiently taken up by cells, with γ(S-am) aeg-PNA being the best in all properties.
Division of Organic Chemistry, National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411008, India.
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D001692:Biological Transport; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D013237:Stereoisomerism
D005456:Fluorescent Dyes; D020135:Peptide Nucleic Acids; D004247:DNA