Anticonvulsant activity and toxicity evaluation of Cu(II) and Zn(II) metal complexes derived from triazole-quinoline ligands.
A novel Cu(II) and Zn(II) complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock induced seizures in Wistar rats and possesses low toxicity, providing a high safety profile.
Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka, India. vkrevankar@rediffmail.com
Naveen Vasudev
NV
Kulkarni
Srinivasa
S
Budagumpi
Gurunath Suresh
GS
Kurdekar
Vidyanand Krishna
VK
Revankar
Suresh
S
Didagi
D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D011804:Quinolines / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy; D014230:Triazoles / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000927:Anticonvulsants; D056831:Coordination Complexes; D008024:Ligands; D011804:Quinolines; D014230:Triazoles; D003300:Copper; C037219:quinoline; D015032:Zinc