Daily online cone beam computed tomography to assess interfractional motion in patients with intact cervical cancer.
OBJECTIVE
To quantify interfraction motion in patients with intact cervical cancer and assess implications for clinical target volume (CTV) coverage and required planning margins.


METHODS
We analyzed 10 patients undergoing external beam radiotherapy using online cone beam computed tomography (CBCT) before each fraction. CTVs were contoured on the planning CT and on each CBCT. Each CBCT was rigidly registered to the planning CT with respect to bony anatomy. The CTV from each CBCT was projected onto the planning CT and compared to the CTV from the planning CT. Uniform three-dimensional expansions were applied to the planning CTV to assess required planning margins. For each fraction, the minimum margin required to encompass the CTV was calculated, and the volume of CTV (on the CBCT) encompassed by the PTV was determined as a function of margin size.


RESULTS
A uniform CTV planning treatment volume margin of 15 mm would have failed to encompass the CTV in 32% of fractions. The mean volume of CTV missed, however, was small (4 cc). The mean planning margin (across patients and fractions) required to encompass the CTV was 15 mm. Variation in margin estimates was high, with interpatient variation being the predominant component. Increased rectal volume was associated with posterior (p < 0.0001) and superior (p = 0.0004) shifts in the CTV, whereas increased bladder volume was associated with superior shifts (p < 0.0001).


CONCLUSIONS
Interfraction motion results in a high probability of missing the CTV using conventional planning margins, but the volume of CTV missed is small. Adaptive radiotherapy approaches are needed to improve treatment accuracy.
Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, University of California San Diego, La Jolla, California 92093-0843, USA.
Neelam
N
Tyagi
John H
JH
Lewis
Catheryn M
CM
Yashar
Daniel
D
Vo
Steve B
SB
Jiang
Arno J
AJ
Mundt
Loren K
LK
Mell
D000704:Analysis of Variance; D054893:Cone-Beam Computed Tomography; D019583:Dose Fractionation, Radiation; D005260:Female; D057918:Fiducial Markers; D006801:Humans; D009068:Movement; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012007:Rectum / Q000000981:diagnostic imaging; D012074:Remission Induction; D047368:Tumor Burden; D001743:Urinary Bladder / Q000000981:diagnostic imaging; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*