[The effect of mithochondria targeted antioxidant SkQ1 on aging, life span and spontaneous carcinogenesis in three mice strains].
Female outbred SHR mice, inbred 129/Sv mice and transgenic HER-2/neu mice were given mitochondria targeted antioxidant SkQ1 with drinking water in the various doses (0,5-2500 nmol/kg day) since the age of 2 months, whereas control animals received tap water. Age-related dynamics of the body weight and temperature, the amount of drinking water and consumed food, estrous function, as well as parameters of the life span and spontaneous carcinogenesis were estimated. As compared with controls, no difference in the parameters of body weight and temperature or amount of consumed food and water in the treated mice of all studied mice strains was revealed. In SkQ1-treated SHR mice, the tendencies of inhibition of the age-dependent disturbances of estrous function and aging appearance were observed. No effect of SkQ1 on estrous function and external view in inbred and transgenic mice was shown. SkQ1 treatment significantly decreased locomotor activity (in 12-15 months old SHR and 129/Sv mice) and exercise tolerance in old (20 months) SHR mice. The treatment with SkQ1 (0,5-50 nmol/kg day) increased parameters of the life span in SHR mice (mean life span, mean life span of the last 10% of survival, median and maximum life span) without significant effect on the life span in 129/Sv and HER-2/neu mice. There was no reliable difference in tumor development in all SkQ1-treated mice strains as compared with the control. The drug considerably inhibited the incidence of age-associated non-tumor pathology in SHR mice. Our data suggest geroprotective activity of SkQ1, and a lack of toxic or carcinogenic activities during long term use.
M H
MH
Iurova
M A
MA
Zabezhinskiĭ
T S
TS
Piskunova
M L
ML
Tyndyk
I G
IG
Popovich
V N
VN
anisimov
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D005260:Female; D018734:Genes, erbB-2; D008136:Longevity / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D010971:Plastoquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D000975:Antioxidants; D010971:Plastoquinone