Neuroprotective properties of afobazole in repeated hemorrhagic stroke modeling in aged rats.
Intraperitoneal administration of afobazole in a dose of 0.1 mg/kg over 2 weeks after repeated modeling of intracerebral post-traumatic hematoma reduces animal mortality, decreases motor coordination disturbances, and improves learning and memory processes in rats.
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Russia. niipharm@mail.ru
V A
VA
Kraineva
S B
SB
Seredenin
D000367:Age Factors; D000818:Animals; D001259:Ataxia / Q000188:drug therapy* / Q000209:etiology; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020202:Cerebral Hemorrhage, Traumatic / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D007274:Injections, Intraperitoneal; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D018696:Neuroprotective Agents