C-reactive protein in relation to early atherosclerosis and periodontitis.
Periodontitis may affect atherosclerosis via the chronic inflammation. We investigated high-sensitivity C-reactive protein (hsCRP) in relation to early vascular atherosclerotic changes in non-symptomatic subjects with and without long-term periodontitis. Carotid ultrasonography with calculation of common carotid artery intima-media area (cIMA) was performed, and hsCRP and atherosclerosis risk factors were analysed in randomly chosen 93 patients with periodontitis and 41 controls. The relationship between hsCRP, cIMA and atherosclerosis risk factors was evaluated with multiple logistic regression analysis. Women displayed lower hsCRP (p < 0.05) and higher serum HDL (p < 0.001) than men. In all patients with periodontitis, cIMA values were higher than in controls. Periodontitis appeared to be a major predictor for increased cIMA (odds ratio, 3.82; 95% confidence interval, 1.19-12.26). Neither of these factors was significantly associated with hsCRP which thus appeared not sensitive enough to be a marker for periodontitis or atherosclerosis. Hence, irrespective of low hsCRP levels, periodontitis appeared to increase the risk for atherosclerosis.
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Box 4064, 141 04, Huddinge, Sweden.
Maha
M
Yakob
Jukka H
JH
Meurman
Tomas
T
Jogestrand
Jacek
J
Nowak
Per-Östen
PÖ
Söder
Birgitta
B
Söder
D000328:Adult; D058070:Asymptomatic Diseases; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D055113:Chronic Periodontitis / Q000097:blood*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003774:Dental Plaque Index; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D009911:Oral Hygiene Index; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D014463:Ultrasonography
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol