Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients.
Tumors from a prospective cohort of adult patients with newly diagnosed glioblastoma (n=73), treated uniformly with radiochemotherapy, were examined for 10q23/PTEN deletion by fluorescence in situ hybridization (FISH). Statistical methods were employed to evaluate the degree of association between 10q23/PTEN deletion status and patient age. Survival analysis was performed using Kaplan-Meier log-rank test and multivariable Cox models to assess the prognostic value of 10q23/PTEN deletion. Interestingly, 10q23/PTEN homozygous deletion was frequent in patients >45 years of age (P=0.034) and the median age of patients harboring PTEN homozygous deletions was significantly higher than those with the retained status (P=0.019). 10q23/PTEN homozygous deletion was associated with shorter survival in the entire cohort as well in patients >45 years (P<0.05), indicating that loss of 10q23/PTEN showed clinical importance in elderly patients. Our study highlights the independent prognostic/predictive value of 10q23/PTEN deletion status as identified by FISH, particularly in glioblastoma patients aged >45 years.
Departments of Neuropathology, Neurosurgery and Biostatistics, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Mallavarapu R
MR
Srividya
Balaram
B
Thota
Bangalore C
BC
Shailaja
Arimappamagan
A
Arivazhagan
Kandavel
K
Thennarasu
Bangalore A
BA
Chandramouli
Alangar S
AS
Hegde
Vani
V
Santosh
D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality; D002869:Chromosome Aberrations; D002879:Chromosomes, Human, Pair 10; D005260:Female; D018628:Gene Dosage; D005909:Glioblastoma / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human