Combinatorial synthesis of 3,5-dimethylene substituted 1,2,4-triazoles.
Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4-trizoles. [formula: see text].
Medicinal and Parallel Chemistry, Global Research and Development, Pfizer, Inc., 700 Chesterfield Pkwy West, Chesterfield, Missouri 63017, USA.
Scott S
SS
Woodard
Kevin D
KD
Jerome
D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry; D007096:Imidoesters / Q000138:chemical synthesis / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
D002264:Carboxylic Acids; D006834:Hydrazines; D007096:Imidoesters; D009570:Nitriles; D054852:Small Molecule Libraries; D014230:Triazoles; C045575:1,2,4-triazole; D008697:Methane