The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death.
Upon apoptosis induction, translocation of mammalian mitochondrial endonuclease G (EndoG) to the nucleus coincides with large-scale DNA fragmentation. Here, we describe for the first time a homologue of EndoG in filamentous fungi by investigating if the Aspergillus nidulans homologue of the EndoG gene, named nucA(EndoG), is being activated during farnesol-induced cell death. Our results suggest that NucA is not involved in cell death, but it plays a role in the DNA-damaging response in A. nidulans.
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café S/N, CEP 14040-903, Ribeirão Preto, São Paulo, Brazil.
Bárbara
B
de Castro Pimentel Figueiredo
Patrícia Alves
PA
de Castro
Taísa Magnani
TM
Dinamarco
Maria Helena S
MH
Goldman
Gustavo Henrique
GH
Goldman
D017209:Apoptosis / Q000187:drug effects; D001233:Aspergillus nidulans / Q000201:enzymology*; D004249:DNA Damage; D004706:Endodeoxyribonucleases / Q000235:genetics / Q000378:metabolism*; D005204:Farnesol / Q000494:pharmacology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D010641:Phenotype; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
D005656:Fungal Proteins; D024101:Mitochondrial Proteins; D011993:Recombinant Fusion Proteins; D005204:Farnesol; D004706:Endodeoxyribonucleases