MGAT5 and disease severity in progressive multiple sclerosis.
MGAT5 was demonstrated to be associated to multiple sclerosis (MS) severity. We evaluated its role in progressive MS. We studied 11 SNPs mapping to MGAT5 in an Italian cohort of primary progressive or progressive-relapsing patients. The rs1257169(G) allele is associated with lower disease severity (p-value = 0.02). Adding the age of onset as covariate, another SNP, rs539588, is nominally significant. None of the SNPs survived after multiple testing correction. These results, even if suggestive of MGAT5 involvement also in progressive MS severity, require a bigger sample size to confirm and better explore the role of this locus in this rare disease course.
INSPE and Department of Neurology, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
Federica
F
Esposito
Jerome
J
Wojcik
Mariaemma
M
Rodegher
Marta
M
Radaelli
Lucia
L
Moiola
Angelo
A
Ghezzi
Ruggero
R
Capra
Paola
P
Brambilla
Melissa
M
Sorosina
Giacomo
G
Giacalone
Vittorio
V
Martinelli
Giancarlo
G
Comi
Hadi
H
Abderrahim
Filippo
F
Martinelli Boneschi
D000328:Adult; D017668:Age of Onset; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D009419:Nerve Tissue Proteins; C479741:MGAT5B protein, human; D017351:N-Acetylglucosaminyltransferases