A novel sensitive detection platform for antitumor herbal drug aloe-emodin based on the graphene modified electrode.
This paper has presented a novel strategy to carry out direct and sensitive determination of antitumor herbal drug aloe-emodin in complex matrices based on the graphene-Nafion modified glassy carbon (GN/GC) electrode. This proposed modified electrode showed good electrochemical response towards aloe-emodin (AE). Compared with the multiwall carbon nanotubes (MWCNTs) modified electrode, the GN/GC electrode has the advantages of higher sensitivity and lower cost. Under the optimized conditions, the calibration curve for AE concentration was linear in the range from 5 nmol/L to 1 μmol/L with the detection limit of 2 nmol/L. In addition, the practical analytical performance of the GN/GC electrode was examined by evaluating the selective detection of AE in natural aloe extracts and human urine samples with satisfied recovery. Therefore, the GN/GC electrode may hold great promise for fast, simple and sensitive detection and biomedical analysis of AE in complex matrices.
The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, PR China.
Juan
J
Li
Jinghua
J
Chen
Xiao-Long
XL
Zhang
Chun-Hua
CH
Lu
Huang-Hao
HH
Yang
D000880:Anthraquinones / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015374:Biosensing Techniques / Q000379:methods; D002138:Calibration; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D005465:Fluorocarbon Polymers / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods; D008956:Models, Chemical; D037742:Nanotubes, Carbon / Q000737:chemistry; D010084:Oxidation-Reduction; D028321:Plant Preparations / Q000494:pharmacology*
D000880:Anthraquinones; D000970:Antineoplastic Agents; D005465:Fluorocarbon Polymers; D037742:Nanotubes, Carbon; D028321:Plant Preparations; C040402:perfluorosulfonic acid; D006108:Graphite; C518327:aloe emodin