Effect of acute and chronic buspirone administration on communicativeness of mice with experience of defeats in social conflicts.
We studied the effect of 5-HT(1A)receptor agonist buspirone on behavior of male C57Bl/6J mice in the "partition" test, which reflects communicativeness of animals. Single administration of buspirone (1 mg/kg) to intact mice and animals experienced defeats in 20 intermale confrontations impaired their communicativeness, especially in intact animals. On the contrary, administration of buspirone (1 mg/kg) to losers starting from day 5 of intermale confrontations for 2 weeks produced a positive effect and prevented impairment of communicativeness by day 20 of confrontations. The role of brain 5-HT(1A)receptors in these processes is discussed.
Sector of Neurogenetics of Social Behavior, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. avgust@bionet.nsc.ru
D F
DF
Avgustinovich
G B
GB
Vishnivetskaya
L A
LA
Koryakina
D000819:Animal Communication; D000818:Animals; D002065:Buspirone / Q000008:administration & dosage / Q000494:pharmacology*; D003220:Conflict, Psychological; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism; D012919:Social Behavior; D018709:Statistics, Nonparametric; D013997:Time Factors
D044282:Receptor, Serotonin, 5-HT1A; D002065:Buspirone