Doxorubicin-loaded albumin nanoparticles: formulation and characterization.
The purpose of the present study was to develop Doxorubicin (Dox) loaded albumin nanoparticles for regional drug release in solid tumours. Bovine serum albumin nanoparticles were prepared by coacervation method. The nanoparticles were characterized using various techniques: Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Dynamic Light Scattering (DLS) technique and Laser Doppler Electrophoresis (LDE) method. The entrapment of Dox in albumin nanoparticles also found out and in vitro release of drug was studied. The results show that the size of albumin nanoparticles increases from Z average of 67 nm to 98 and 106 nm for two different methods; A and B of drug loading, respectively. The SEM results confirm the spherical shape of nanoparticles which made at 4 degrees C. The results show that the size of nanoparticles decreases by decreasing temperature in their production process.
Mazandaran University of Medical Sciences, School of Pharmacy, Sari 48175/861, Iran ZC.
S
S
Honary
M
M
Jahanshahi
P
P
Golbayani
P
P
Ebrahimi
K
K
Ghajar
D000418:Albumins / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004317:Doxorubicin / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles
D000418:Albumins; D004317:Doxorubicin