[Clinical study on the relapsd leukemia patients with graft versus host disease after allogeneic hematopoietic stem cell transplantation].
OBJECTIVE
To explore the dissociation of graft-versus-leukemia (GVL) effects from graft-versus-host disease (GVHD) in the patients who experienced GVHD during leukemia relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT).


METHODS
The primary disease, disease status, GVHD, response to donor lymphocyte infusion (DLI) and prognosis were analysed in 11 leukemia patients who relapsed with GVHD after allo-HSCT.


RESULTS
Of the 11 relapsed, 5 were acute lymphoblastic leukemia and 6 acute myeloid leukemia. Five received DLI before relapse and all developed post-DLI GVHD, including 2 grade II acute GVHD (aGVHD), 1 limited chronic GVHD (cGVHD) plus grade II aGVHD, and 2 extensive cGVHD. After relapse of the 5 patients, 2 received Chemo-DLI, one achieved CR with extensive cGVHD and then relapsed again, the other didn't achieved CR. The other 6 patients didn't received DLI before relapse and also developed post-HSCT GVHD while relapsing, including 3 extensive cGVHD, 1 grade I aGVHD and 2 grade II-IV aGVHD. After relapse, these 6 patients received Chemo-DLI, 2 achieved CR and then relapsed again, 4 didn't achieved CR.


CONCLUSIONS
The elicited GVHD after allo-HSCT may not accompany effective GVL effects inhibiting leukemic relapse.
Peking University Institute of Hematology & Peking University People's Hospital, Beijing 100044, China.
Xiao-Hui
XH
Zhang
Hai-Xia
HX
Fu
Kai-Yan
KY
Liu
Lan-Ping
LP
Xu
Dai-Hong
DH
Liu
Huan
H
Chen
Wei
W
Han
Yu-Hong
YH
Chen
Feng-Rong
FR
Wang
Jing-Zhi
JZ
Wang
Ting
T
Zhao
Yu
Y
Wang
Yao
Y
Chen
Xiao-Jun
XJ
Huang
D006086:Graft vs Host Disease; D020544:Graft vs Leukemia Effect; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma