Reduced number of actinic keratoses with topical application of DNA repair enzyme creams.
BACKGROUND
Actinic keratosis is regarded as a carcinoma in situ by some dermatologists and its incidence continues to rise. Exposure to ultraviolet (UV) radiation is considered to be an important risk factor for developing these pre-malignant lesions. DNA repair enzymes have been shown to reverse sun-damage, resulting in reduced rates of actinic keratoses and non-melanoma skin cancers in specific patient populations.


METHODS
Seventeen patients were evaluated for differences in actinic keratoses following topical application of T4N5 liposome lotion over 48 weeks.


RESULTS
Compared to baseline, a statistically significant reduction in the number of actinic keratoses was seen following the treatment period.


CONCLUSIONS
This study suggests that DNA repair enzyme creams effectively reduce the number of actinic keratoses in normal individuals with moderate-to-severe photodamaged skin.
Department of Dermatology, David Geffen School of Medicine at UC LA, Los Angeles, CA, USA. tdeboyes@ucla.edu
Telia
T
DeBoyes
David
D
Kouba
David
D
Ozog
Edgar
E
Fincher
Lauren
L
Moy
Kathryn
K
Iwata
Ronald
R
Moy
D000287:Administration, Topical; D000368:Aged; D045643:DNA Repair Enzymes / Q000008:administration & dosage / Q000627:therapeutic use*; D043224:Deoxyribonuclease (Pyrimidine Dimer) / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008081:Liposomes; D008875:Middle Aged; D012720:Severity of Illness Index; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects; D014764:Viral Proteins / Q000008:administration & dosage / Q000627:therapeutic use*
D008081:Liposomes; D014764:Viral Proteins; C470698:endonuclease V, phage T4; D043224:Deoxyribonuclease (Pyrimidine Dimer); D045643:DNA Repair Enzymes