G-octamer formation from N⁹ modified guanine derivatives.
The properties of the self-assembly of two lipophilic guanine derivatives, 2',3',5'-O-tris(tert-butyldimethylsilyl)-guanosine and N⁹-(3,5-bis(tert-butyldimethylsilyloxy)-benzyl)-guanine, are described. In the presence of K+, both guanine derivatives self-associate into D₄-symmetric octamers consisting of two G-quartets stacked around a central ion.
Department of Chemistry and Biochemistry, Loyola Marymount University, 1 LMU Drive, Los Angeles, CA 90045, USA. jmccallu@lmu.edu
Jeremy
J
McCallum
Solomon
S
Amare
Rebecca
R
Nolan
D002942:Circular Dichroism; D054856:G-Quadruplexes; D006151:Guanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017646:Organosilicon Compounds / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry
C459744:2',3',5'-O-tert-butyldimethylsilyl-N-tert-butyldimethylsilyl-8-(13)C-guanosine; D017646:Organosilicon Compounds; D006151:Guanosine; D011188:Potassium