Porous bioactive glass scaffolds for local drug delivery in osteomyelitis: development and in vitro characterization.
A new bioactive glass-based scaffold was developed for local delivery of drugs in case of osteomyelitis. Bioactive glass having a new composition was prepared and converted into porous scaffold. The bioactivity of the resulting scaffold was examined by in vitro acellular method. The scaffolds were loaded with two different drugs, an antibacterial or antifungal drug. The effects of the size of the scaffold, drug concentration, and dissolution medium on drug release were studied. The scaffolds were further coated with a degradable natural polymer, chitosan, to further control the drug release. Both the glass and scaffold were bioactive. The scaffolds released both the drugs for 6 weeks, in vitro. The results indicated that the bigger the size and the higher the drug concentration, the better was the release profile. The scaffolds appeared to be suitable for local delivery of the drugs in cases of osteomyelitis.
Bioceramic and Coating Division, Central Glass & Ceramic Research Institute, Raja S C Mallick Road, Kolkata, 700032, India.
Chidambaram
C
Soundrapandian
Someswar
S
Datta
Biswanath
B
Kundu
Debabrata
D
Basu
Biswanath
B
Sa
D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D015725:Fluconazole / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D000077734:Gatifloxacin; D005898:Glass; D006801:Humans; D010019:Osteomyelitis / Q000188:drug therapy*; D016062:Porosity; D012995:Solubility
D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D024841:Fluoroquinolones; D015725:Fluconazole; D000077734:Gatifloxacin