Identification of novel ASK1 inhibitors using virtual screening.
Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases. We identified novel ASK1 inhibitors by virtual screening from the public chemical library collected by Chemical Biology Research Initiative (CBRI) at the University of Tokyo.
Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., 2-19-8 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan. okamoto@pharmadesign.co.jp
Masako
M
Okamoto
Nae
N
Saito
Hirotatsu
H
Kojima
Takayoshi
T
Okabe
Kohsuke
K
Takeda
Hidenori
H
Ichijo
Toshio
T
Furuya
Tetsuo
T
Nagano
D002851:Chromatography, High Pressure Liquid; D008024:Ligands; D048848:MAP Kinase Kinase Kinase 5 / Q000037:antagonists & inhibitors*; D013058:Mass Spectrometry; D008958:Models, Molecular; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*
D008024:Ligands; D047428:Protein Kinase Inhibitors; D048848:MAP Kinase Kinase Kinase 5