Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats.
The intra-plantar injection of carrageenan elicited an inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues. Histidine, n-acetylcysteine and diclofenac decreased paw thickness, and neutrophil infiltration in the paw tissues. The anti-inflammatory effect induced by co-administration of histidine and n-acetylcysteine with diclofenac, was more than that obtained from histidine and n-acetylcysteine administered alone. The results suggested that histidine, n-acetylcysteine and diclofenac produced anti-inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan. Inhibition of cyclooxygenase products such as prostaglandins may be involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine.
Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, P.O. Box 1177, Urmia University, Urmia 57153, Iran. amirabbasfarshid@gmail.com
Amir Abbas
AA
Farshid
Esmaeal
E
Tamaddonfard
Fatere
F
Yahyaee
D000111:Acetylcysteine / Q000008:administration & dosage / Q000494:pharmacology*; D000208:Acute Disease; D000818:Animals; D002351:Carrageenan; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology; D006614:Hindlimb / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D006639:Histidine / Q000008:administration & dosage / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D007267:Injections / Q000379:methods; D008297:Male; D020556:Neutrophil Infiltration / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D016861:Cyclooxygenase Inhibitors; D016166:Free Radical Scavengers; D004008:Diclofenac; D006639:Histidine; D002351:Carrageenan; D000111:Acetylcysteine