Translation deregulation in B-cell lymphomas.
B-cell lymphomas are a heterogeneous group of diseases that can arise at different stages of B-cell development, often as a result of errors in the cells' unique ontogeny. Common oncogenic features are often observed, including chromosomal rearrangements, somatic mutations and transcriptional change. Disruption of translation regulation is also frequently implicated in both B-cell lymphoma development and progression. Deregulation of translation in lymphomagenesis can arise through changes to the proteins constituting the translational machinery or to their regulators, and to changes in miRNA (microRNA) expression.
MRC Toxicology Unit, Hodgkin Building, P.O. Box 138, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK. eh118@le.ac.uk
Emilie
E
Horvilleur
Lindsay A
LA
Wilson
Anne E
AE
Willis
D001402:B-Lymphocytes / Q000473:pathology / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016393:Lymphoma, B-Cell / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D014176:Protein Biosynthesis
D035683:MicroRNAs