Anti-interferon-γ autoantibody and opportunistic infections: case series and review of the literature.
Immune defects in interleukin-12-dependent interferon-gamma (IFN-γ) pathways are associated with disseminated infections caused by non-tuberculous mycobacteria (NTM) and Salmonella. Recently, there have been an increasing number of reports of acquired autoantibodies to IFN-γ in adults, especially in Asian patients. We describe here three human immunodeficiency virus-negative Thai adults who had persistent or recurrent disseminated infections caused by NTM, Salmonella, and other opportunistic pathogens, possibly due to anti-IFN-γ autoantibodies. The antibodies were shown to exhibit very high inhibitory activity to IFN-γ. Two patients also developed Sweet's syndrome during the course of infections. In addition, we also review all previous reports of patients with anti-IFN-γ antibodies who were susceptible to NTM and Salmonella infections.
Division of Allergy and Clinical Immunology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
T
T
Kampitak
G
G
Suwanpimolkul
S
S
Browne
C
C
Suankratay
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D012480:Salmonella Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D016463:Sweet Syndrome / Q000175:diagnosis; D013785:Thailand
D001323:Autoantibodies; D007371:Interferon-gamma