Challenges and opportunities in dermal/transdermal delivery.
Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs. Further advances in transdermal delivery depend on the ability to overcome the challenges faced regarding the permeation and skin irritation of the drug molecules. Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications. As evident from the ongoing clinical trials of a wide variety of drugs for various clinical conditions, there is a great future for transdermal delivery of drugs.
College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA.
Kalpana S
KS
Paudel
Mikolaj
M
Milewski
Courtney L
CL
Swadley
Nicole K
NK
Brogden
Priyanka
P
Ghosh
Audra L
AL
Stinchcomb
D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D006801:Humans; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D012869:Skin Absorption / Q000187:drug effects; D013678:Technology, Pharmaceutical / Q000379:methods
D004364:Pharmaceutical Preparations