Lobular breast cancer in men: case report and review of the literature.
BACKGROUND
Lobular breast cancer in men is an extremely infrequent occurrence due to the lack of lobules and acini in the male breast. Such a rare case is described here.


METHODS
A 74-year-old patient presented with a sizeable lesion in the right breast, which proved to be a lobular carcinoma. Genetic studies excluded Klinefelter's syndrome, though revealing an interesting genetic multiformity feature. This case represented a lobular carcinoma in a genotypically male patient under no exogenous or endogenous estrogenic influence.


CONCLUSIONS
The increasing number of male lobular breast cancer cases should be explored more extensively with particular emphasis placed on causally related genetic and hormonal factors.
Breast Unit, 1st Propaedeutic Surgical Dept., University of Athens, Hippocration General Hospital, Athens, Greece.
Theodoros
T
Mariolis-Sapsakos
George
G
Theodoropoulos
Ioannis I
II
Flessas
Filotheos
F
Orfanos
Nikolaos
N
Orfanos
Evangelos A
EA
Konstantinou
Evangelos
E
Konstadinou
Flora
F
Zagouri
Dimitris
D
Vlachodimitropoulos
George C
GC
Zografos
D000368:Aged; D044963:Biopsy, Fine-Needle; D001940:Breast / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D007621:Karyotyping; D008297:Male; D015411:Mastectomy, Modified Radical; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging