Olfactory bulb serotonin level modulates olfactory recognition in the neonate rat.
Role of serotonin in olfactory recognition was tested by depleting the olfactory bulb serotonin during postnatal day (PND) 1 - 4 following administration of 5,7-dihydroxytryptamine. Significant difference in the olfactory recognition test was observed during PND5-7; control pups successfully recognized and oriented towards their mother; whereas treated pups failed to recognize their mother odour. Later on, during PND12-14, both group of pups responded equally in the recognition test. Levels of olfactory bulb serotonin were depleted (53.3%) in the treated pups on PND-8, which was restored on PND-14 with only 15% variation. Further analysis demonstrated that depletion of serotonin in olfactory bulb did not affect the normal suckling and weight gain, it only modulates olfactory recognition.
Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, India.
C Prisila
CP
Dulcy
A
A
Ganesh
Emmanuvel
E
Rajan
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008297:Male; D009812:Odorants; D009830:Olfactory Bulb / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents / Q000494:pharmacology; D013997:Time Factors
D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin