Fasting serum leptin level correlates with mid-arm fat area in peritoneal dialysis patients.
Leptin correlates with body fat content and plays a pivotal role in inflammatory response. This study aimed to investigate the relationships of fasting serum leptin levels and the anthropometric fat components among peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 40 PD patients. Leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Body weight (r=0.424; P=0.006), waist circumference (r=0.352; P=0.026), body mass index (BMI; r=0.483; P=0.002), body fat mass (r=0.352; P=0.026), high sensitivity C-reactive protein (hs-CRP; r=0.494; P=0.001), triceps skinfold thickness (TSF; r=0.505; P=0.001), mid-arm circumference (MAC; r=0.471; P=0.002), and mid-arm fat area (MAFA; r=0.564; P<0.001) were positively correlated, while high density lipoprotein (HDL)-cholesterol (r=-0.345; P=0.028) was negatively correlated with fasting serum leptin levels among the PD patients. Multivariate forward stepwise linear regression analysis showed that MAFA (R(2)=0.318, P=0.011) was the independent predictor of fasting serum leptin levels among the PD patients. In conclusion, fasting leptin level was positively associated with body fat composition (body weight, waist circumference, BMI, body fat mass, TSF, MAC, and MAFA) and hs-CRP among PD patients, and MAFA was the independent predictor of fasting serum leptin levels among the PD patients.
School of Medicine, Tzu Chi University, Taiwan.
Te-Chao
TC
Fang
Chung-Jen
CJ
Lee
Chih-Hsien
CH
Wang
Hung-Hsiang
HH
Liou
Bang-Gee
BG
Hsu
D000328:Adult; D000368:Aged; D000886:Anthropometry; D001132:Arm / Q000033:anatomy & histology*; D050218:Body Fat Distribution; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010530:Peritoneal Dialysis / Q000379:methods*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods; D055105:Waist Circumference
D020738:Leptin; D002097:C-Reactive Protein