Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner.
We report metabolic images of (13)C, following injection of a bolus of hyperpolarized [1-(13)C] pyruvate in a live rat. The data were acquired on a clinical scanner, using custom coils for volume transmission and array reception. Proton blocking of all carbon resonators enabled proton anatomic imaging with the system body coil, to allow for registration of anatomic and metabolic images, for which good correlation was achieved, with some anatomic features (kidney and heart) clearly visible in a carbon image, without reference to the corresponding proton image. Parallel imaging with sensitivity encoding was used to increase the spatial resolution in the SI direction of the rat. The signal to noise ratio in was in some instances unexpectedly high in the parallel images; variability of the polarization among different trials, plus partial volume effects, are noted as a possible cause of this.
GE Healthcare Technologies, Global Applied Sciences Lab, Fremont, CA, United States. james.tropp@med.ge.com
James
J
Tropp
Janine M
JM
Lupo
Albert
A
Chen
Paul
P
Calderon
Don
D
McCune
Thomas
T
Grafendorfer
Esin
E
Ozturk-Isik
Peder E Z
PE
Larson
Simon
S
Hu
Yi-Fen
YF
Yen
Fraser
F
Robb
Robert
R
Bok
Rolf
R
Schulte
Duan
D
Xu
Ralph
R
Hurd
Daniel
D
Vigneron
Sarah
S
Nelson
D000465:Algorithms; D000818:Animals; D002250:Carbon Radioisotopes / Q000032:analysis / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000662:veterinary*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation*; D008280:Magnetics / Q000295:instrumentation*; D008297:Male; D019289:Pyruvic Acid / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D051598:Whole Body Imaging / Q000295:instrumentation / Q000662:veterinary
D002250:Carbon Radioisotopes; D019289:Pyruvic Acid