Solvent-free thermocyclization of the unactivated linear gramicidin S precursor and analogues.
A convenient thermocyclization of the linear gramicidin S precursor and its analogues is demonstrated. With the preorganized β-sheet conformation, the unactivated linear precursors can cyclize into the corresponding head-to-tail cyclic products in high yield after being heated under solvent-free conditions.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. lssalk@mail.sysu.edu.cn
Lin-Kun
LK
An
Run-Lin
RL
Li
Ying-Lin
YL
Zuo
Lian-Quan
LQ
Gu
D003500:Cyclization; D006096:Gramicidin / Q000031:analogs & derivatives / Q000737:chemistry*; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry; D013696:Temperature
D012997:Solvents; D006096:Gramicidin