Cell fate transitions and the replication timing decision point.
Recent findings suggest that large-scale remodeling of three dimensional (3D) chromatin architecture occurs during a brief period in early G1 phase termed the replication timing decision point (TDP). In this speculative article, I suggest that the TDP may represent an as yet unappreciated window of opportunity for extracellular cues to influence 3D architecture during stem cell fate decisions. I also describe several testable predictions of this hypothesis.
Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. gilbert@bio.fsu.edu
David M
DM
Gilbert
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D002843:Chromatin; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D016193:G1 Phase; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
D018797:Cell Cycle Proteins; D002843:Chromatin