Impact of superdisintegrants on efavirenz release from tablet formulations.
Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrants extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). In vitro dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the ability to discriminate between the formulations. The t50 and t80 values were indicative of the fact that the drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.
RA Chem Pharma Limited, Road No 18 IDA, Nacharam, Hyderabad-500076, India. rajeshyelchuri@rediffmail.com
Yelchuri Vijaya
YV
Rajesh
Jagdish
J
Balasubramaniam
Koduri
K
Bindu
Ramachandran
R
Sridevi
Maroju
M
Swetha
Vinay Umesh
VU
Rao
D000480:Alkynes; D048588:Benzoxazines / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003521:Cyclopropanes; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000737:chemistry; D006245:Hardness Tests; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000737:chemistry
D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D003692:Delayed-Action Preparations; D005079:Excipients; D018894:Reverse Transcriptase Inhibitors; D013607:Tablets; C098320:efavirenz