[Fluorescence study on the interactions between carbon nanotubes and bovine serum albumin].
As a new family of nanomaterials, carbon nanotubes (CNTs) exhibit unique properties such as their capacity to penetrate into the cells and low immunogenicity, which have attracted increasing attention in biomedical field and make their application in drug and gene transfer systems being possible. So getting more information about the interaction of CNTs with biomacromolecules is crucial for further investigation of CNTs in therapeutic applications. The interaction between CNTs and BSA under physiological condition was investigated by fluorescence quenching, synchronous fluorescence and red edge excitation shift (REES)method. The results showed that CNTs could significantly decrease the fluorescence intensity of BSA. While the results of synchronous fluorescence and REES indicated that CNTs almost had no influence on the conformation of BSA. So the authors concluded that the mechanism of interaction between CNTs and BSA was non-specific adsorption.
Division of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China. violet0569@sina.com
Shan-shan
SS
Li
Hua
H
He
Zhe
Z
Chen
Jun
J
Zha
Pham-Huy
PH
Chuong
D000327:Adsorption; D005453:Fluorescence; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D037742:Nanotubes, Carbon; D012710:Serum Albumin, Bovine