Prostaglandin E receptors as inflammatory therapeutic targets for atherosclerosis.
Prostaglandin E receptors (EPs) are the G-protein-coupled receptors (GPCRs) that respond to type E(2) prostaglandin (PGE(2)). Data has shown that PGE(2) may function as an endogenous anti-inflammatory mediator by suppressing the production of cytokines. However, other studies have demonstrated that PGE(2), a pro-inflammatory mediator produced by various cell types within the wounded vascular wall, plays a crucial role in early atherosclerotic development. These contradictory results may be due to the versatility of EPs. Experimental data suggest an individual role for each PGE(2) receptor, such as EP(1), EP(2), EP(3) and EP(4), in atherosclerosis. In this review, the roles of EPs in atherosclerosis are summarized, and the value of EPs as new therapeutic targets for atherosclerosis is explored.
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, School of Chemistry & Biotechology, Yunnan University of Nationalities, Kunming 650031, PR China. yanghku@yahoo.cn
Cui
C
Yang
Xiuxia
X
Liu
Qing
Q
Cao
Qian
Q
Liang
Xiaohua
X
Qiu
D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D016503:Drug Delivery Systems; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D018078:Receptors, Prostaglandin E / Q000378:metabolism*
D018078:Receptors, Prostaglandin E