Effects of a nanocomplex containing antioxidant, lipid, and amino acid on thermal burn wound surface.
Dihydroquercetin (flavonoid of plant origin) immobilized with an amino acid in lecithin nanoparticles promotes reduction of inflammatory reactions in the wound after thermal burn. The use of a liposomal complex in burn injury stabilizes endogenous antioxidant system and limits the secondary necrotic zone in the wounds. The treatment was associated with intensification of skin regeneration processes and reparation of hairy follicles and sebaceous glands.
Sector of Functional Biochemistry, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
A A
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Naumov
Yu V
YV
Shatalin
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MM
Potselueva
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D054709:Lecithins; D008081:Liposomes; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
D000596:Amino Acids; D000975:Antioxidants; D054709:Lecithins; D008081:Liposomes; D011794:Quercetin; C003377:taxifolin