Preparation and complex characterization of silica holmium sol-gel monoliths.
Amorphous, sol-gel derived SiO(2) are known to biocompatible and bioresorbable materials. Biodegradable and inert materials containing radioactive isotopes have potential application as delivery vehicles of the beta radiation to the cancer tumors inside the body. Incorporation of holmium in the sol-gel derived SiO(2) could lead to the formation of a biodegradable material which could be used as carrier biomaterial for the radiation of radioactive holmium to the various cancer sites. The homogeneity of the prepared sol-gel silica holmium monoliths was investigated by Back Scattered Electron Imaging of Scanning Electron Microscope equipped with Energy Dispersive X-ray Analysis, X-ray Induced Photoelectron Spectroscopy and Nuclear Magnetic Resonance Spectroscopy. The biodegradation of the monoliths was investigated in Simulated Body Fluid and TRIS (Trizma pre-set Crystals) solution. The results show that by suitable tailoring of the sol-gel processing parameters holmium can be homogeneously incorporated in the silica matrix with a controlled biodegradation rate.
Turku Biomaterials Centre, University of Turku, Turku, Finland. dana.cacaina@yahoo.com
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Cacaina
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Areva
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Laaksonen
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Simon
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Ylänen
D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006695:Holmium / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D016062:Porosity; D012542:Scattering, Radiation; D058428:Silica Gel / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000737:chemistry* / Q000494:pharmacology
D001672:Biocompatible Materials; D004337:Drug Carriers; D058428:Silica Gel; D012822:Silicon Dioxide; D006695:Holmium