Synthesis, biological activity of salidroside and its analogues.
Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs-Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 µmol/l and 60 µmol/l, respectively.
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China.
Yibing
Y
Guo
Yahong
Y
Zhao
Cheng
C
Zheng
Ying
Y
Meng
Yumin
Y
Yang
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D029771:Rhodiola / Q000737:chemistry
D005960:Glucosides; D010636:Phenols; C009172:rhodioloside