Hypopharyngeal squamous cell carcinoma with hematogenous intracranial metastases: case report.
BACKGROUND
Intracranial metastases are rarely clinically diagnosed in patients with hypopharyngeal squamous cell carcinoma (SCC). In almost all cases, metastatic locations were found at the cavernous sinus and have been considered to develop as perineural invasions.


METHODS
We present a case of hypopharyngeal SCC with distant intracranial metastases through hematogenous spreading. Two cerebral parenchymal metastases from the hypopharyngeal SCC were histologically analyzed in a 49-year-old male patient. The right temporal lesion was diagnosed by craniotomy and treated with radiotherapy. The right occipital lesion was treated with stereotactic radiosurgery (SRS).


CONCLUSIONS
To the best of our knowledge, there are no reports of hypopharyngeal SCC with cerebral metastases that developed via the hematogenous route. Radiotherapy along with surgery provides better outcomes, and SRS may improve the effect of treatments. Any subclinical neurological deficits should not be neglected, because awareness of this syndrome can lead to earlier diagnosis and alteration in treatment.
Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan, Republic of China.
Cheng-Chi
CC
Lee
Shih-Ming
SM
Jung
Chien-Yu
CY
Lin
Kuo-Chen
KC
Wei
D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods