Adipose-derived stem cells for myocardial infarction.
In recent years, stem cell treatment of myocardial infarction has elicited great enthusiasm upon scientists and physicians alike, thus making the finding of a suitable cell a compulsory subject for modern medicine. Due to its potential, accessibility and efficiency of harvesting, adipose tissue has become one of the most attractive sources of stem cells for regenerative therapies. The differentiation capacity and the paracrine activity of these cells has made them an optimal candidate for the treatment of a diverse range of diseases from immunological disorders as graft versus host disease to cardiovascular pathologies like peripheral ischemia. In this review, we will focus on the use of stem cells derived from adipose tissue for treatment of myocardial infarction, with special attention to their putative in vivo mechanisms of action.
Hematology and Cell Therapy and Foundation for Applied Medical Research, Division of Cancer, University of Navarra, Av. Pío XII 36, Pamplona, Spain.
Manuel
M
Mazo
Juan José
JJ
Gavira
Beatriz
B
Pelacho
Felipe
F
Prosper
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000637:transplantation*; D019899:Paracrine Communication; D020127:Recovery of Function; D012038:Regeneration; D033581:Stem Cell Transplantation; D016896:Treatment Outcome