Vitamin D is associated with atheroprotective high-density lipoprotein profile in postmenopausal women.
BACKGROUND
Low vitamin D has been associated with low levels of high-density lipoprotein (HDL) cholesterol, a marker of coronary risk. Whether atheroprotective HDL particle composition accounts for this association and whether fat affects this association is not known.


OBJECTIVE
To explore the association between HDL particle composition and 25-hydroxy vitamin D (25[OH]D) in post-menopausal women.


METHODS
Vitamin D levels and lipoprotein composition were assessed in fasting blood samples of apparently healthy women from a diverse Chicago community. Visceral (VAT) and subcutaneous (SAT) abdominal fat area were assessed using computed tomography. Total body fat mass was measured by dual-energy X-ray absorptiometry.


RESULTS
We enrolled 78 women (50% black; 50% white), age 48 to 64 years, all of whom were participants in a longitudinal study of fat patterning. They had a mean 25[OH]D of 31 ± 15 μg/L, HDL cholesterol 57±11 mg/dL, and large HDL particle subclass 8.6±3.4 μmol/L. In a multivariable-adjusted regression model, each 5 μg/L higher 25[OH]D predicted 0.57 μmol/L (95%CI 0.20-0.95) higher large HDL particles, independent of race, season, and total HDL particle concentration. This association was only partially confounded by total body fat mass (0.49, 95%CI 0.10-0.89), SAT (0.50, 95%CI 0.11-0.90), or VAT (0.37, 95%CI 0.01-0.74). Age did not significantly influence the strength of associations.


CONCLUSIONS
Higher 25[OH]D levels are associated with large HDL particles. This association is stronger than that of HDL cholesterol and only partially confounded by body fat. Theoretically, vitamin D may protect against cardiovascular risk by promoting formation of large HDL particles, affecting reverse cholesterol transport.
Department of Preventive Medicine, Rush University Medical Center, 1700 W. Van Buren St, Ste 470, Chicago, IL 60612, USA. rasa_kazlauskaite@rush.edu
Rasa
R
Kazlauskaite
Lynda H
LH
Powell
Chaitanya
C
Mandapakala
John F
JF
Cursio
Elizabeth F
EF
Avery
James
J
Calvin
D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D050153:Abdominal Fat / Q000033:anatomy & histology; D050154:Adiposity; D050197:Atherosclerosis / Q000097:blood* / Q000517:prevention & control*; D002112:Calcifediol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry; D008137:Longitudinal Studies; D009682:Magnetic Resonance Spectroscopy; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D010316:Particle Size; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014807:Vitamin D; D015652:25-Hydroxyvitamin D 2; C104450:25-hydroxyvitamin D; D002112:Calcifediol