Spontaneous and in vitro induced apoptosis of lymphocytes and neutrophils in patients with alcohol dependence.
Spontaneous and induced apoptosis of neutrophils and lymphocytes was studied in alcoholics during the abstinent syndrome and in healthy individuals. In alcoholics, the levels of lymphocyte and neutrophil apoptosis at the receptor and cellular levels were higher than in healthy subjects. Blood cells from alcohol addicts and normal individuals similarly react to stimuli (hyperthermia and synthetic glucocorticoid prednisolone) in vitro.
Laboratory of Cell and Biomolecular Studies, Institute of Mental Health, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
S A
SA
Ivanova
N M
NM
Vyalova
E V
EV
Zhernova
N A
NA
Bokhan
D000328:Adult; D000437:Alcoholism / Q000276:immunology* / Q000473:pathology; D000911:Antibodies, Monoclonal; D017209:Apoptosis / Q000502:physiology*; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000473:pathology* / Q000502:physiology; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology* / Q000502:physiology; D011239:Prednisolone; D018709:Statistics, Nonparametric; D019014:fas Receptor / Q000378:metabolism
D000911:Antibodies, Monoclonal; C491901:FAS protein, human; D019014:fas Receptor; D011239:Prednisolone