Relationship of plasma apolipoprotein M with proprotein convertase subtilisin-kexin type 9 levels in non-diabetic subjects.
OBJECTIVE
Apolipoprotein M (apoM) retards atherosclerosis development in murine models, and may be regulated by pathways involved in LDL metabolism. Proprotein convertase subtilisin-kexin type 9 (PCSK9) plays a key role in LDL receptor processing. We determined the extent to which plasma apoM is related to PCSK9 levels in subjects with varying degrees of obesity.


METHODS
We sought correlations between plasma apoM and PCSK9, measured using recently developed ELISAs, in 79 non-diabetic subjects.


RESULTS
ApoM and PCSK9 levels were both correlated positively with total cholesterol, non-HDL cholesterol, LDL cholesterol and apoB (P < 0.05 to P < 0.001). ApoM correlated positively with PCSK9 in lean individuals (n = 37, r = 0.337, P = 0.041), but not in overweight subjects (n = 32, r = 0.125, P = 0.50) and in obese subjects (n = 10, r = -0.055, P = 0.88).


CONCLUSIONS
The PCSK9 pathway may contribute to plasma apoM regulation in humans. The influence of PCSK9 on circulating apoM appears to be modified by adiposity.
Paul J W H
PJ
Kappelle
Gilles
G
Lambert
Björn
B
Dahlbäck
Lars Bo
LB
Nielsen
Robin P F
RP
Dullaart
D050154:Adiposity; D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood; D000075243:Apolipoproteins M; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D054834:Lipocalins; D008875:Middle Aged; D009426:Netherlands; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D050177:Overweight / Q000097:blood* / Q000503:physiopathology; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012044:Regression Analysis; D012697:Serine Endopeptidases / Q000097:blood*
C400523:APOM protein, human; D001053:Apolipoproteins; D001055:Apolipoproteins B; D000075243:Apolipoproteins M; D015415:Biomarkers; D008078:Cholesterol, LDL; D054834:Lipocalins; D002784:Cholesterol; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9; D043484:Proprotein Convertases; D012697:Serine Endopeptidases