Lipotoxicity and the development of heart failure: moving from mouse to man.
Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigation (Son et al., 2010) found that cardiac-specific PPARγ overexpression caused heart failure with intracardiac triglyceride accumulation. Overexpressing PPARγ on a PPARα-/- background improved cardiac function, suggesting that specific lipid metabolites and lipid packaging determine cardiac lipotoxicity.
Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA. wstanley@medicine.umaryland.edu
William C
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Stanley
Fabio A
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Recchia