Chlorosulfolipids: structure, synthesis, and biological relevance.
Chlorosulfolipids have been isolated from freshwater algae and from toxic mussels. They appear to have a structural role in algal membranes and have been implicated in Diarrhetic Shellfish Poisoning. Further fascinating aspects of these compounds include their stereochemically complex polychlorinated structures and the resulting strong conformational biases, and their poorly understood (yet surely compelling) biosynthesis. Discussions of each of these topics and of efforts in structural and stereochemical elucidation and synthesis are the subject of this Highlight.
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
D Karl
DK
Bedke
Christopher D
CD
Vanderwal
D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D000460:Chlorophyta / Q000737:chemistry* / Q000166:cytology / Q000378:metabolism; D005618:Fresh Water; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008387:Marine Toxins / Q000737:chemistry / Q000506:poisoning; D051379:Mice; D015394:Molecular Structure; D057096:Shellfish Poisoning
D008055:Lipids; D008387:Marine Toxins; C553538:hexachlorosulfolipid