Expression of {beta}-catenin, MUC1 and c-met in diffuse-type gastric carcinomas: correlations with tumour progression and prognosis.
Previous studies on the immunoreactivity of β-catenin, MUC1 and c-met in gastric carcinomas regarding survival and clinico-pathological features led to contradictory results. Therefore, a series of 94 diffuse-type and mixed-type subcardial gastric carcinomas according to the Laurén classification were investigated to elucidate possible correlations with clinico-pathological and prognostic data. An immunohistochemical study was performed to detect the expression of β-catenin, MUC1 and c-met. Loss of membranous/cytoplasmic β-catenin expression in the tumour centre correlated with pT, loss at the invasion front with pTNM stage. MUC1 expression in the tumour centre correlated with lymph node metastasis and pTNM stage. c-Met did not show such associations. In multivariate survival analysis, loss of membranous/ cytoplasmic β-catenin expression as well as a strong MUC1 expression at the tumour invasion front represent independent predictors of a worse prognosis. On the other hand, c-met expression did not exhibit any prognostic value in this study.
Institute of Pathology, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany.
Monika F
MF
Retterspitz
Stefan P
SP
Mönig
Stephanie
S
Schreckenberg
Paul M
PM
Schneider
Arnulf H
AH
Hölscher
Hans P
HP
Dienes
Stephan E
SE
Baldus
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism* / Q000556:secondary; D003593:Cytoplasm; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D015996:Survival Rate; D051176:beta Catenin / Q000378:metabolism*
C495270:CTNNB1 protein, human; C060192:MUC1 protein, human; D018396:Mucin-1; D051176:beta Catenin; D019859:Proto-Oncogene Proteins c-met