[Should we believe in the interaction between proton pump inhibitors (PPI) and clopidogrel].
Recently, some authors have examined the possibility of an interaction between proton pump inhibitors (especially omeprazole) and clopidogrel. Pharmacodynamically, this interaction is proven and leads to a reduction in anti-aggregation activity. Nevertheless, the clinical implications are not fully clarified. We are all waiting for a randomised prospective study assessing specifically this issue. Meanwhile, caution is recommended when prescribing PPI in patients taking clopidogrel.
Service de médecine interne générale, Département de médecine interne, HUG, 1211 Genève 14. Valentina.Pelloni@hcuge.ch
Valentina
V
Besse
Eric
E
Gerstel
D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D000077144:Clopidogrel; D065731:Cytochrome P-450 CYP2C19; D004347:Drug Interactions; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives*
D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D000077144:Clopidogrel; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D013988:Ticlopidine