Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models.
Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.
Department of Pharmacology and Zebrafish Neuroscience Research Consortium, Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Adam
A
Stewart
Nadine
N
Wu
Jonathan
J
Cachat
Peter
P
Hart
Siddharth
S
Gaikwad
Keith
K
Wong
Eli
E
Utterback
Thomas
T
Gilder
Evan
E
Kyzar
Alan
A
Newman
Dillon
D
Carlos
Katie
K
Chang
Molly
M
Hook
Catherine
C
Rhymes
Michael
M
Caffery
Mitchell
M
Greenberg
James
J
Zadina
Allan V
AV
Kalueff
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001007:Anxiety / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D010641:Phenotype; D009435:Synaptic Transmission / Q000187:drug effects*; D015027:Zebrafish
D014151:Anti-Anxiety Agents