Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.
From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7-hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, α-conidendrin (12) showed strong CYP3A4 inhibition with an IC(50) value of 0.2 μM.
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. tezuka@inm.u-toyama.ac.jp
Yasuhiro
Y
Tezuka
Kouhei
K
Morikawa
Feng
F
Li
Lidyawati
L
Auw
Suresh
S
Awale
Takahiro
T
Nobukawa
Shigetoshi
S
Kadota
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D020231:Colletotrichum / Q000737:chemistry*; D051544:Cytochrome P-450 CYP3A; D065692:Cytochrome P-450 CYP3A Inhibitors; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D020946:Taxus / Q000382:microbiology; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014934:Wood / Q000737:chemistry
C558153:(3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol; C558151:(7R)-7-hydroxytaxiresinol; C558152:2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001713:Biphenyl Compounds; D065692:Cytochrome P-450 CYP3A Inhibitors; D016166:Free Radical Scavengers; D005663:Furans; D049934:Isocoumarins; D007529:Isoflavones; D017705:Lignans; D010851:Picrates; D013764:Tetrahydronaphthalenes; C421915:conidendrin; C004931:1,1-diphenyl-2-picrylhydrazyl; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human