Unexpected deviation from diene behaviour of uracil amidine: towards synthesis of some pyrido[2,3-d]pyrimidine derivatives.
Condensation products obtained from the treatment of uracil amidine with preformed or in situ generated suitably substituted olefins unexpectedly undergo intramolecular cyclisation during silica gel chromatography to generate pyrido[2,3-d]pyrimidines. Various reaction conditions are studied and the altered nature of the uracil amidine molecule is further explored by reacting it with different suitably substituted alkenes.
Medicinal Chemistry Division, North East Institute of Science and Technology (CSIR), Jorhat, 785006 Assam, India.
Rupam
R
Sarma
Kalyan Jyoti
KJ
Borah
Yuvaraj
Y
Dommaraju
Dipak
D
Prajapati
D000578:Amidines / Q000737:chemistry; D002850:Chromatography, Gel; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry*
D000578:Amidines; D011741:Pyrimidine Nucleosides; D012263:Ribonucleosides; D014498:Uracil