Successful treatment of refractory simple motor status epilepticus with lacosamide and levetiracetam.
Lacosamide has been reported to have been successfully used for non-convulsive status epilepticus after benzodiazepine failure, and convulsive status epilepticus after benzodiazepine and levetiracetam failure. We report a case of simple motor status epilepticus refractory to benzodiazepines and multiple anti-epileptic medications (AEDs) over 4 days. The addition of lacosamide in combination with existing levetiracetam aborted the continuous seizure with maintenance of seizure freedom through the most recent follow-up at 4 weeks.
David Geffen School of Medicine at UCLA, Neurology, Los Angeles, CA, United States; VA Greater Los Angeles Health Care System, Neurology, Los Angeles, CA 90095, United States. llchen@mednet.ucla.edu
Leo L K
LL
Chen
Zulfi
Z
Haneef
Andrew
A
Dorsch
Inna
I
Keselman
John M
JM
Stern
D000081:Acetamides / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D006801:Humans; D000078334:Lacosamide; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013226:Status Epilepticus / Q000175:diagnosis / Q000188:drug therapy*
D000081:Acetamides; D000927:Anticonvulsants; D000077287:Levetiracetam; D000078334:Lacosamide; D010889:Piracetam