Molecular aspects on the interaction of quercetin and its metal complexes with DNA.
Flavonoids occupy an important position in chemistry and pharmacology. Various flavonoids, particularly quercetin have potential to form molecular complexes with nucleic acid structure and have attracted recent attention for their prospective clinical and pharmacological utility. This review highlights the properties of quercetin and its different metal complexes as well as their interactions with DNA reported by several research groups. Various analytical techniques were employed including absorbance, fluorescence and circular dichroism spectroscopies, viscosity and voltammetry to provide more details about binding mechanism of these materials with DNA.
Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, Iran.
Jafar Ezzati Nazhad
JE
Dolatabadi
D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage; D010084:Oxidation-Reduction / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology; D011794:Quercetin / Q000737:chemistry / Q000378:metabolism*
D056831:Coordination Complexes; D020011:Protective Agents; D004247:DNA; D011794:Quercetin