MADOR: a new tool to calculate decrease of effective doses in human after DTPA therapy.
Abstract models have been developed to describe dissolution of Pu/Am/Cm after internal contamination by inhalation or wound, chelation of actinides by diethylene triamine penta acetic acid (DTPA) in different retention compartments and excretion of actinide-DTPA complexes. After coupling these models with those currently used for dose calculation, the modelling approach was assessed by fitting human data available in IDEAS database. Good fits were obtained for most studied cases, but further experimental studies are needed to validate some modelling hypotheses as well as the range of parameter values. From these first results, radioprotection tools are being developed: MAnagement of DOse Reduction after DTPA therapy.
Laboratoire de Radiotoxicologie, CEA/DSV/iRCM/SREIT, BP 12, F-91680 Bruyères le Châtel, France. paul.fritsch@cea.fr
P
P
Fritsch
O
O
Grémy
C
C
Hurtgen
P
P
Bérard
L
L
Grappin
J L
JL
Poncy
D008671:Actinoid Series Elements / Q000032:analysis; D000465:Algorithms; D001646:Bile; D002614:Chelating Agents / Q000737:chemistry; D003198:Computer Simulation; D005243:Feces; D006801:Humans; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D008962:Models, Theoretical; D004369:Pentetic Acid / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000188:drug therapy; D011835:Radiation Protection / Q000379:methods*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D014556:Urine
D008671:Actinoid Series Elements; D002614:Chelating Agents; D011837:Radiation-Protective Agents; D004369:Pentetic Acid