Genotoxic effects of textile printing dye exposed workers in India detected by micronucleus assay.
The textile printing industry in South India employs a great number of workers that may possibly be exposed to toxic compounds. In the present study, subjects from textile printing units were investigated for the presence of genetic damage in their peripheral blood lymphocytes using micronucleus assay. Proliferation was also investigated using a nuclear division index. It was found that the micronucleus frequency was considerably greater in exposed subjects than in non exposed control subjects, but division was not increased in a statistically significant way. For the time being, this investigation should be considered as a preliminary study in which the influence of potential confounders could be adequately assessed. However, our results are non-ambiguous, indicating a potential health risk in these workers.
Department of Biotechnology, Karpagam University, Coimbatore, Tamilnadu, India. sudhasellappa@yahoo.co.in
Sudha
S
Sellappa
Shibily
S
Prathyumnan
Shyn
S
Joseph
Kripa S
KS
Keyan
Vellingiri
V
Balachandar
D000328:Adult; D015415:Biomarkers; D004396:Coloring Agents / Q000009:adverse effects*; D004247:DNA / Q000032:analysis; D004249:DNA Damage; D005260:Female; D006801:Humans; D007194:India; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D015162:Micronucleus Tests; D016273:Occupational Exposure / Q000009:adverse effects*; D018709:Statistics, Nonparametric; D013783:Textile Industry; D055815:Young Adult
D015415:Biomarkers; D004396:Coloring Agents; D004247:DNA