Switchable, biocompatible surfaces based on glycerol copolymers.
Two thermoresponsive copolymers based on glycerol were synthesized and tethered onto gold surfaces via SAM formation. Below the LCST protein resistant surfaces were obtained while fibrinogen adsorbed above the LCST. It was demonstrated that these switchable properties can be applied to control fibroblast cell adhesion and detachment.
Institute of Chemistry and Biochemistry, Freie Universitaet Berlin, Takustr. 3, 14195 Berlin, Germany. marie.weinhart@fu-berlin.de
Marie
M
Weinhart
Tobias
T
Becherer
Rainer
R
Haag
D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005990:Glycerol / Q000737:chemistry* / Q000378:metabolism; D006046:Gold; D006801:Humans; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties
D001672:Biocompatible Materials; D011108:Polymers; D006046:Gold; D005990:Glycerol