Death due to asthma in two adolescents with sickle cell disease.
In one prospective cohort study, a diagnosis of asthma was associated with an increased risk of mortality in individuals with sickle cell anemia or HbSS. However, a direct relationship between death and asthma exacerbation could not be documented. This report examines two adolescents with sickle cell disease (SCD) who died during worsening symptoms consistent with asthma. Autopsies in both individuals demonstrated pulmonary airway smooth muscle hyperplasia, basement membrane thickening, and eosinophilia, consistent with bronchial asthma. Individuals with SCD and asthma warrant ongoing education, treatment, and surveillance for life-threatening complications of asthma.
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA.
Joshua J
JJ
Field
Jennifer
J
Horst
Robert C
RC
Strunk
Frances V
FV
White
Michael R
MR
DeBaun
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000401:mortality; D001249:Asthma / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D016535:Bronchial Hyperreactivity; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult