Medicinal Flowers. XXXI. Acylated oleanane-type triterpene saponins, Sasanquasaponins I-V, with antiallergic activity from the flower buds of Camellia sasanqua.
The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia sasanqua THUNB. were found to show inhibitory activities on the release of β-hexosaminidase from rat basophile leukemia (RBL-2H3) cells. From the 1-butanol-soluble fraction, five new acylated oleanane-type triterpene saponins, sasanquasaponins I-V, were isolated together with a known saponin and their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The principal saponin constituents, sasanquasaponins I-III, with an acyl group at the 22-position of the aglycon part showed the inhibitory effects on the release of β-hexosaminidase and some structure-activity relationships were reported.
Kyoto Pharmaceutical University, Kyoto, Japan.
Hisashi
H
Matsuda
Seikou
S
Nakamura
Katsuyoshi
K
Fujimoto
Ryo
R
Moriuchi
Yuta
Y
Kimura
Noriko
N
Ikoma
Yuki
Y
Hata
Osamu
O
Muraoka
Masayuki
M
Yoshikawa
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D028244:Camellia / Q000737:chemistry*; D045744:Cell Line, Tumor; D035264:Flowers / Q000737:chemistry; D015471:Leukemia, Basophilic, Acute / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D051381:Rats; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D018926:Anti-Allergic Agents; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; D009828:Oleanolic Acid; D001619:beta-N-Acetylhexosaminidases