Standard-dose tegafur combined with uracil is not safe treatment after severe toxicity from 5-fluorouracil or capecitabine.
Maarten J
MJ
Deenen
Wim E
WE
Terpstra
Annemieke
A
Cats
Henk
H
Boot
Jan H M
JH
Schellens
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D054067:Dihydropyrimidine Dehydrogenase Deficiency; D042943:Dihydrouracil Dehydrogenase (NADP) / Q000037:antagonists & inhibitors; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D011355:Prodrugs / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000188:drug therapy; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects*
D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D003841:Deoxycytidine; D005641:Tegafur; D000069287:Capecitabine; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil