Cellular expression of INK4a gene in cells of bladder cancer associated with human papilloma virus-16.
Hyperexpression of p16(INK4a) protein is an early marker of cervical cancer. Hyperexpression of INK4a gene encoding this protein at the level of mRNA and p16(INK4a) was detected in tumor cells of some patients with bladder cancer associated with human papilloma virus-16. However, in contrast to cervical cancer, this phenomenon in urothelial carcinomas does not correlate with expression of human papilloma virus-16 oncogenes E6 and E7.
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. gmvolgareva@front.ru
G M
GM
Volgareva
L E
LE
Zavalishina
D A
DA
Golovina
Yu Yu
YY
Andreeva
V D
VD
Ermilova
O B
OB
Trofimova
D A
DA
Kuevda
O Yu
OY
Shipulina
V A
VA
Glazunova
Shuling
S
Cheng
L S
LS
Pavlova
N L
NL
Cheban
V B
VB
Matveev
G A
GA
Frank
D014408:Biomarkers, Tumor / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D017931:DNA Primers / Q000235:genetics; D052162:Human papillomavirus 16; D006801:Humans; D007150:Immunohistochemistry; D009856:Oncogene Proteins, Viral / Q000378:metabolism; D050725:Papillomavirus E7 Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000821:virology*
D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D017931:DNA Primers; C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C059731:oncogene protein E7, Human papillomavirus type 16