Characteristics and drug utilization patterns of new users of rosuvastatin and other statins in four countries.
OBJECTIVE
This study was undertaken to increase understanding of the utilization of a newly introduced statin through evaluation of characteristics of 'real-life' patients in a pharmacoepidemiology program in the USA, the Netherlands, the UK and Canada.


METHODS
This was an observational analysis of prospectively collected data from primary care patients classified as new users of rosuvastatin or any other statin. New users (naïve or switched initiators) of rosuvastatin were compared with initiators of other statins, as identified from automated healthcare databases in the first 1 to 2 years of rosuvastatin availability. Demographics, statin doses, previous statin use and other lipid-lowering therapies, and relevant comorbidities were recorded. The main outcome measure was proportion of naïve and non-naïve statin users in patients prescribed rosuvastatin or 'other statins'.


RESULTS
Among 346.547 new statin users identified in the cohorts, 46.838 (13.5%) were new users of rosuvastatin and most (84.1%) were statin-naïve. Patients receiving rosuvastatin were more likely to have been previously treated with another statin or non-statin lipid-lowering therapy and tended to be younger, compared with first users of other statins.


CONCLUSIONS
These findings suggest that rosuvastatin is preferentially prescribed to patients who have not responded satisfactorily to established treatment.
Division of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
A T
AT
McAfee
L A G
LA
Rodríguez
W G
WG
Goettsch
A
A
González-Pérez
S
S
Johansson
E E
EE
Ming
M A
MA
Wallander
R M C
RM
Herings
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada; D005260:Female; D005464:Fluorobenzenes / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy*; D009426:Netherlands; D017891:Pharmacoepidemiology; D011446:Prospective Studies; D011743:Pyrimidines / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000627:therapeutic use*; D016896:Treatment Outcome; D006113:United Kingdom; D014481:United States
D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium