Clinical features and follow-up of four new cases of facial-onset sensory and motor neuronopathy.
In this study we report three patients with facial-onset sensory and motor neuronopathy (FOSMN), including the first female to be described. A fourth rather atypical case of a pyramidal syndrome with a fast rate of progression is also described. These cases raise the question as to whether upper motor neuron impairment is involved in FOSMN and whether there is a link between this syndrome and amyotrophic lateral sclerosis. The existence of this syndrome suggests that it may be wise to monitor all patients with isolated idiopathic trigeminal sensory neuropathy to ensure that this type of motor neuron disease is not overlooked.
Department of Neurology and Movement Disorders, CHU La Timone, Marseille, France.
Frederique
F
Fluchere
Annie
A
Verschueren
Pascal
P
Cintas
Jerome
J
Franques
Jacques
J
Serratrice
Pierre J
PJ
Weiller
Jean P
JP
Azulay
Jean
J
Pouget
Shahram
S
Attarian
D005155:Facial Nerve Diseases / Q000503:physiopathology*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*; D012678:Sensation Disorders / Q000503:physiopathology*; D017211:Treatment Failure; D020433:Trigeminal Nerve Diseases / Q000503:physiopathology*