Inhibition of contractions of nerve processes in calcium-free medium.
The possibility of blocking contractile activity of damaged neurites was studied on viable isolated neurons from Lymnaea stagnalis mollusks. Retraction was blocked in more than 80% cells plunged in Ringer's solution free from Ca(2+) or containing 20 mM CoCl(2). Nimodipine and nitrendipine significantly inhibited neurite contractions. Inhibition of neurite contractile activity can be useful for reducing diastasis after nerve crossing.
Laboratory of Functional Morphology and Physiology of Neuron, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. sotnikov@kolt.infran.ru
O S
OS
Sotnikov
N Yu
NY
Vasiagina
G I
GI
Rybakova
S V
SV
Chepur
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D003035:Cobalt; D007552:Isotonic Solutions; D008195:Lymnaea / Q000166:cytology*; D016501:Neurites / Q000187:drug effects*; D009553:Nimodipine; D009568:Nitrendipine; D000077331:Ringer's Solution
D002121:Calcium Channel Blockers; D007552:Isotonic Solutions; D003035:Cobalt; D009553:Nimodipine; D000077331:Ringer's Solution; D009568:Nitrendipine; C018021:cobaltous chloride; D002118:Calcium