Antiulcerogenic activity of Lantana camara leaves on gastric and duodenal ulcers in experimental rats.
BACKGROUND
Lantana camara L. (Verbenaceae), a widely growing shrub has been used in the traditional medicine for treating many ailments. The objective of the present study was to evaluate the effects of methanolic extract of Lantana camara leaves on gastric and duodenal ulcers.


METHODS
The antiulcerogenic effect of methanolic extract of Lantana camara was evaluated in aspirin induced gastric ulcerogenesis in pyloric ligated rats, ethanol induced gastric ulcer, and cysteamine induced duodenal ulcer models. The extract was administered orally at two different doses of 250 mg/kg and 500 mg/kg. The lipid peroxidation, reduced glutathione levels of ethanol induced gastric ulcer model and inhibition zone in diameter against Helicobacter pylori also determined.


RESULTS
The L. camara extract significantly (P<0.01) reduced ulcer index, total acidity and significantly (P<0.01) increased the gastric pH of aspirin+pylorus-ligation induced ulcerogenesis and ethanol induced gastric ulcer models. The extract also significantly (P<0.01) reduced the ulcer index of cysteamine induced duodenal ulcer. The L. camara showed significant (P<0.01) reduction in lipid peroxidation and increase in reduced glutathione levels. The inhibition zone in diameter of extract against H. pylori was 20mm.


CONCLUSIONS
The methanolic extract of Lantana camara leaves shown healing of gastric ulcers and also prevents development of duodenal ulcers in rats.
Department of Pharmacology, Ultra College of Pharmacy, Madurai, India. rsvsathish2000@yahoo.co.in
R
R
Sathish
Bhushan
B
Vyawahare
K
K
Natarajan
D000818:Animals; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D032410:Lantana / Q000737:chemistry*; D015227:Lipid Peroxidation; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy*
D010936:Plant Extracts