Hepatic and cerebral energy production system in rats with acute and chronic ethanol intoxication.
We studied the effects of ethanol on the energy production system in the brain and liver in acute and chronic intoxications. Ethanol was found to inhibit mitochondrial respiratory chain in the liver. Acute ethanol intoxication results in uncoupling of oxidative phosphorylation. NAD-dependent respiration prevails in chronic intoxication. In the brain, ethanol exposure induces a compensated low-energy shift with activation of fast mitochondrial metabolic cluster and uncoupling of oxidative phosphorylation.
Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. zuci@ya.ru
Z V
ZV
Petrova
D A
DA
Korshunov
V A
VA
Slepichev
Y G
YG
Zyuz'kova
E A
EA
Yanovskaya
G A
GA
Stykon
V V
VV
Udut
D000435:Alcoholic Intoxication / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004579:Electron Transport / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D018709:Statistics, Nonparametric
D000431:Ethanol