Comparison of the remineralizing potential of child formula dentifrices.
BACKGROUND
Although child formula fluoridated dentifrices can be used safely by young children their remineralizing capability remains questionable.


OBJECTIVE
To evaluate the remineralizing potential of child formula dentifrices on primary teeth.


METHODS
In vitro single-section technique utilizing a 7 days pH-cycling model.


METHODS
Primary teeth were placed in demineralizing solution for 96 h to produce artificial carious lesions 100 μm deep, and then cut longitudinally into 50 sections 100-150 μm thick and randomly assigned to five groups. Sections in Groups A to D were treated with dentifrices containing 500 ppm AmF, 500 ppm MFP, 500 ppm MFP and xylitol, or 500 ppm NaF, respectively. Group E sections were treated with a nonfluoridated dentifrice.


METHODS
Lesions were evaluated using polarized light microscopy and microradiography.


RESULTS
Group D (500 ppm NaF) sections exhibited a significant decrease in lesion depth, whereas those in Group E (nonF) showed a significant increase in depth (P<0.05, paired t-test). Decrease in lesion progression was observed in Groups A, B and C.


CONCLUSIONS
The 500 ppm NaF dentifrice demonstrated remineralization of carious lesions by virtue of a significant decrease in lesion depth; whereas dentifrices that contained AmF, MFP and MFP with xylitol decelerated the progression of demineralization.
Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR.
Manikandan
M
Ekambaram
Anut
A
Itthagarun
Nigel Martyn
NM
King
D002327:Cariostatic Agents / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D002648:Child; D003802:Dentifrices / Q000008:administration & dosage* / Q000737:chemistry; D003959:Diamines / Q000008:administration & dosage; D018450:Disease Progression; D005459:Fluorides / Q000008:administration & dosage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008852:Microradiography; D008859:Microscopy, Polarization; D008903:Minerals / Q000032:analysis; D010710:Phosphates / Q000008:administration & dosage; D012969:Sodium Fluoride / Q000008:administration & dosage; D013997:Time Factors; D017001:Tooth Demineralization / Q000473:pathology / Q000628:therapy; D014089:Tooth Remineralization / Q000379:methods*; D014094:Tooth, Deciduous / Q000187:drug effects / Q000473:pathology; D014993:Xylitol / Q000008:administration & dosage
D002327:Cariostatic Agents; D003802:Dentifrices; D003959:Diamines; D008903:Minerals; D010710:Phosphates; C012980:fluorophosphate; C495399:Olaflur; D012969:Sodium Fluoride; D005459:Fluorides; D014993:Xylitol