Evaluation of binding properties of Plantago psyllium seed mucilage.
Mucilage extracted from Plantago psyllium seeds was evaluated for inertness and safety parameters. The suitability of psyllium mucilage for a pharmaceutical binder was assessed in paracetamol tablets. Properties of the granules prepared using different concentrations of psyllium mucilage was compared with PVP and tragacanth. Psyllium mucilage at 5 % (m/m) was found to be comparable with 3 % (m/m) of PVP. Investigated paracetamol tablets indicated that psyllium mucilage can retard the drug release.
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. majsaeedi@yahoo.com
Majid
M
Saeedi
Katayoun
K
Morteza-Semnani
Farshad
F
Ansoroudi
Saeed
S
Fallah
Gholamreza
G
Amin
D000082:Acetaminophen / Q000008:administration & dosage; D000269:Adhesives / Q000737:chemistry*; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D011620:Psyllium / Q000737:chemistry*; D012639:Seeds; D013607:Tablets; D014144:Tragacanth / Q000737:chemistry
D000269:Adhesives; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D000082:Acetaminophen; D011620:Psyllium; D014144:Tragacanth; D011205:Povidone