Nuclear ploidy is an indicator of malignancy endocrine pancreatic tumor.
Comparative morphometric and densitometric studies of cell nuclei in endocrine tumors of various differentiation degree and endocrinocytes of Langerhans islet in the adjacent pancreatic tissue were carried out. Index of proliferative activity, aneuploidy coefficient, and histogram of nuclear DNA content are recommended as additional criteria for the diagnosis of endocrine tumor malignancy.
Department of Pathological Anatomy, A. V. Vishnevsky Institute of Surgery, Moscow, Russia.
E A
EA
Dubova
M N
MN
Podgornova
A I
AI
Shchyogolev
D000293:Adolescent; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure*; D049109:Cell Proliferation; D056915:DNA Copy Number Variations / Q000235:genetics; D003720:Densitometry; D005260:Female; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D011003:Ploidies; D012189:Retrospective Studies