Oseltamivir-resistant pandemic (H1N1) 2009 virus, South Korea.
To identify oseltamivir resistance, we analyzed neuraminidase H275Y mutations in samples from 10 patients infected with pandemic (H1N1) 2009 virus in South Korea who had influenza that was refractory to antiviral treatment with this drug. A neuraminidase I117M mutation that might influence oseltamivir susceptibility was detected in sequential specimens from 1 patient.
Korea Centers for Disease Control and Prevention, Seoul, South Korea.
Hwajung
H
Yi
Joo Yeon
JY
Lee
Eun Hye
EH
Hong
Mi Seon
MS
Kim
Donghyok
D
Kwon
Jang Hoon
JH
Choi
Woo Young
WY
Choi
Ki Soon
KS
Kim
Jong Koo
JK
Lee
Hee Bok
HB
Oh
Chun
C
Kang
D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002675:Child, Preschool; D004196:Disease Outbreaks; D024882:Drug Resistance, Viral; D005260:Female; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000235:genetics*; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000235:genetics*; D053139:Oseltamivir / Q000494:pharmacology / Q000627:therapeutic use*; D056910:Republic of Korea / Q000453:epidemiology; D014764:Viral Proteins / Q000235:genetics
D000998:Antiviral Agents; D014764:Viral Proteins; D053139:Oseltamivir; D009439:Neuraminidase