Leiomyosarcoma with synchronous clear cell ovarian carcinoma.
BACKGROUND
Uterine leiomyomas are typically considered benign lesions. Despite aggressive management, they can be unpredictable and eventually exhibit disease recurrence several years following initial treatment.


METHODS
We report a case involving a 55-year-old woman who was treated for a uterine leiomyoma at an outside medical institution 20 years ago. In November 2009, she presented to our gynecologic oncology service with a complex mass. Following surgery, the patient was diagnosed with a 16 cm ovarian mass and a synchronous leiomyosarcoma; the latter neoplasm appeared to originate from a previously resected uterine leiomyoma.


CONCLUSIONS
The coexistence of these two lesions is exceedingly rare. We suspect that the leiomyosarcoma developed from either the patient's original uterine leiomyoma or leiomyomatosis peritonealis disseminata.
Gynecologic Oncology Associates, Hoag Cancer Center, Hoag Memorial Hospital Presbyterian, Newport Beach, CA, USA.
Mark
M
Rettenmaier
Howard D
HD
Epstein
Lisa N
LN
Abaid
Karen A
KA
Bechtol
Bram H
BH
Goldstein
D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D000971:Antineoplastic Combined Chemotherapy Protocols; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007414:Intestinal Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery; D007889:Leiomyoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D009852:Omentum / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010052:Ovariectomy; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D058994:Salpingectomy; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D014599:Uterus / Q000473:pathology