Impact of intensive school-based nutrition education and lifestyle interventions on insulin resistance, β-cell function, disposition index, and subclinical inflammation among Asian Indian adolescents: a controlled intervention study.
OBJECTIVE
The present study was designed to assess the impact of intensive and repetitive nutrition education and lifestyle interventions on insulin resistance, β-cell function, disposition index (DI), and subclinical inflammation in Asian Indian adolescents (15-17 years) residing in North India.


METHODS
In this prospective study, two matched schools were randomly allocated to the intervention (n = 56; 31 boys and 25 girls) or control group (n = 50; 30 boys and 20 girls). The intervention consisted of seven components: (1) Dissemination of health-related information through lectures and focused group discussions, (2) planning of activities such as quizzes, (3) individual counseling of students, (4) promotion of physical activity, (5) change in the canteen menu to healthier alternatives, (6) conducting health camps involving parents and teachers, and (7) training of student volunteers for sustainability of the program in school. Impact of intervention was studied on surrogate markers of insulin resistance, β-cell function, disposition index, and subclinical inflammation.


RESULTS
At 6 months follow-up, significantly higher (P = 0.037) mean value of homeostasis model assessment denoting β-cell function (HOMA-βCF) was seen in the intervention group compared to the control group, whereas high sensitivity C-reactive protein (hs-CRP) was significantly lowered (P < 0.001). The increase (30.3 ± 73.4; P < 0.037) observed in the DI in adolescents in the intervention group was significantly higher compared to the control group. The Pearson's coefficient of correlation in the intervention group showed that the Δ-decrease in mean waist circumference was significantly correlated (r = 0.267, P < 0.05) with Δ-decrease in homeostasis model assessment of insulin resistance (HOMA-IR).


CONCLUSIONS
The intervention model developed by us could be used for amelioration of insulin resistance with potential of preventing type 2 diabetes mellitus in Asian Indian adolescents.
National Diabetes, Obesity and Cholesterol Foundation, SDA, New Delhi, India.
Neha
N
Singhal
Anoop
A
Misra
Priyali
P
Shah
Seema
S
Gulati
Suryaprakash
S
Bhatt
Suresh
S
Sharma
Ravindra Mohan
RM
Pandey
D000293:Adolescent; D015992:Body Mass Index; D016022:Case-Control Studies; D053198:Child Nutrition Sciences; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D005260:Female; D006266:Health Education / Q000379:methods*; D006706:Homeostasis; D006801:Humans; D007194:India; D007249:Inflammation; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000166:cytology; D008019:Life Style; D008297:Male; D011446:Prospective Studies; D012574:Schools