Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery.
Acid-degradable microcapsules were prepared via an interfacial polymerization. Degradation of the thin wall of the capsules leads to all-or-nothing cargo release. The only byproducts of degradation are acetone, and a non-toxic triamide. Proof-of-concept experiments showed that cargo can be delivered to and released in cells.
Department of Chemistry, UC Berkeley, Berkeley, CA, USA.
Kyle E
KE
Broaders
Stefan J
SJ
Pastine
Sirisha
S
Grandhe
Jean M J
JM
Fréchet
D000143:Acids / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D017239:Paclitaxel / Q000008:administration & dosage
D000143:Acids; D001672:Biocompatible Materials; D002214:Capsules; D004337:Drug Carriers; D017239:Paclitaxel