A copper-mediated cyclization reaction of hydrazine with enediynones providing pyrazolo[1,5-a]pyridines.
2,7-Disubstituted pyrazolo[1,5-a]pyridines were synthesized in good chemical yields by the reaction of enediynones with hydrazine, followed by addition of copper chloride. This reaction can tolerate many functional groups.
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
Hung-Chou
HC
Wu
Long-Chih
LC
Hwang
Ming-Jung
MJ
Wu
D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D053281:Enediynes / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
D053281:Enediynes; D006834:Hydrazines; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; C418567:enediynone; C447480:pyrazolo(3,4-b)pyridine; C029424:hydrazine; D003300:Copper