[Dinitrosyl iron complexes--structure and biological functions].
Formation of dinitrosyl iron complexes (DNICs), which can be described by general formula Fe(NO)2(L)2, where L is carbonyl-, nitrosyl- or imino- complexing ligand, was observed in many kinds of living organisms, in a wide spectrum of physiological conditions associated with inflammation, ischemia/reperfusion and cancer. Accumulation of DNICs coincides with intensified production of nitric oxide in macrophages, neurons, endothelial cells, Langerhans' cells and hepatocytes. Low-molecular thiol-containing DNICs (DNIC-(RS)2) show vasodilatory action and they are proposed to play a role of nitric oxide transducers and stabilizers. DNICs have been shown to modulate redox potential of the cell via inhibition of glutathione-dependent enzymes, such as glutathione reductase, S-transferase and peroxidase. Although there is a convincing experimental evidence for their NO and NO+ donating function, the nature of DNICs formed in biological systems, their stability and biological role is still a matter of discussion.
Center of Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 16 Dorodna St., 03-195 Warszawa, Poland.
Hanna
H
Lewandowska
Kamil
K
Brzóska
Sylwia
S
Meczyńska-Wielgosz
Karolina
K
Rumianek
Grzegorz
G
Wójciuk
Marcin
M
Kruszewski
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism; D009589:Nitrogen Oxides / Q000737:chemistry* / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
D009589:Nitrogen Oxides; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D005982:Glutathione Transferase