Concise syntheses of trifluoromethylated cyclic and acyclic analogues of cADPR.
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Xiangchen
X
Huang
Min
M
Dong
Jian
J
Liu
Kehui
K
Zhang
Zhenjun
Z
Yang
Liangren
L
Zhang
Lihe
L
Zhang
D020013:Calcium Signaling; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D019271:Hypoxanthine / Q000737:chemistry; D019837:Ryanodine Receptor Calcium Release Channel
D006845:Hydrocarbons, Fluorinated; D019837:Ryanodine Receptor Calcium Release Channel; D036563:Cyclic ADP-Ribose; D019271:Hypoxanthine