Design and synthesis of novel polyglycerol hybrid nanomaterials for potential applications in drug delivery systems.
The synthesis of a new drug delivery system based on hybrid nanomaterials containing a β-CD core and hyperbranched PG is described. Conjugating PG branches onto β-CD not only increases its water solubility but also affects its host/guest properties deeply. It can form molecular inclusion complexes with small hydrophobic guest molecules such as ferrocene or FITC with reasonable release. In addition, the achievable payloads are significantly higher as for carriers such as hyperbranched PGs. Short-term in vitro cytotoxicity and hemocompatibility tests on L929 cell lines show that the hybrid nanomaterial is highly biocompatible. Due to their outstanding properties, β-CD-g-PG hybrid nanomaterials are introduced as promising materials for nanomedicine, e.g., for drug delivery issues.
Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 14588-89694, Tehran, Iran.
Ali
A
Zarrabi
Mohsen
M
Adeli
Manouchehr
M
Vossoughi
Mohammad Ali
MA
Shokrgozar
D000818:Animals; D001672:Biocompatible Materials; D002850:Chromatography, Gel; D016503:Drug Delivery Systems / Q000379:methods*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D016650:Fluorescein-5-isothiocyanate / Q000378:metabolism; D005990:Glycerol / Q000138:chemical synthesis* / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D051379:Mice; D008970:Molecular Weight; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D001672:Biocompatible Materials; D011108:Polymers; C043941:polyglycerol; D016650:Fluorescein-5-isothiocyanate; D005990:Glycerol