Proneurotensin/neuromedin N secreted from small cell lung carcinoma cell lines as a potential tumor marker.
Proteins secreted from specific cancer cells have a high potential for use as tumor markers. We identified secreted proteins produced by 15 different carcinoma cell lines grown in serum-free medium using MS/MS. Proneurotensin/neuromedin N (proNT/NMN) was found in conditioned medium from four of seven small cell lung carcinoma cell lines but not from eight nonsmall cell lung carcinoma cell lines. These results indicate proNT/NMN has potential as a specific tumor marker of small cell lung carcinoma.
Shizuoka Cancer Center Research Institute, Nagaizumi-cho, Shizuoka, Japan.
Shun-Ichiro
S
Ogura
Kumi
K
Kaneko
Shoji
S
Miyajima
Keiichi
K
Ohshima
Ken
K
Yamaguchi
Tohru
T
Mochizuki