Relationship between drinking patterns and the risk of type 2 diabetes: the Kansai Healthcare Study.
BACKGROUND
Moderate alcohol consumption is associated with a decreased risk of type 2 diabetes. However, the relationship between drinking patterns, such as the weekly frequency of alcohol consumption and the quantity per drinking day, and the incidence of type 2 diabetes has not been sufficiently addressed.


METHODS
Study participants included 10 631 Japanese men aged 40-55 years without type 2 diabetes at entry. Type 2 diabetes was diagnosed if a fasting plasma glucose level was ≥7.0 mmol/l or if participants were taking diabetes medications. Data on alcohol consumption were obtained from questionnaires.


RESULTS
During the 37 172 person-years of follow-up, we confirmed 878 cases of type 2 diabetes. Frequent alcohol consumption was associated with a low risk of type 2 diabetes. Compared to non-drinkers, the multiple-adjusted HR for those who drank 4-7 days weekly was 0.76 (95% CI, 0.63 to 0.92). To assess the association between drinking pattern and type 2 diabetes, we examined the joint association of the weekly frequency and the quantity per drinking day with type 2 diabetes. Men who consumed 0.1-2.0 or 2.1-4.0 US standard drinks per drinking day on 4-7 days weekly had a lower risk of type 2 diabetes (HR 0.74, 95% CI 0.58 to 0.95; HR 0.74, 95% CI 0.60 to 0.91, respectively) compared to non-drinkers.


CONCLUSIONS
More frequent alcohol consumption lowered the risk of type 2 diabetes. Light to moderate alcohol consumption per drinking day on 4-7 days weekly lowered the risk of type 2 diabetes compared to non-drinkers.
Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan. ksato@med.osaka-cu.ac.jp
Kyoko Kogawa
KK
Sato
Tomoshige
T
Hayashi
Nobuko
N
Harita
Hideo
H
Koh
Isseki
I
Maeda
Ginji
G
Endo
Yoshiko
Y
Nakamura
Hiroshi
H
Kambe
Chiharu
C
Kiyotaki
D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D040242:Risk Reduction Behavior; D011795:Surveys and Questionnaires