Recent biomimetic and organocatalytic syntheses of alpha-tocopherol.
We report here on our efforts to develop new strategies for the synthesis of alpha-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of alpha-tocopherol with overall up to 29% yield from commercially available material and up to 94% de.
Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel.
Antoinette
A
Chougnet
Kegang
K
Liu
Wolf D
WD
Woggon
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002839:Chromans / Q000737:chemistry; D008968:Molecular Conformation; D018716:Molecular Mimicry; D011392:Proline / Q000031:analogs & derivatives; D013237:Stereoisomerism; D024502:alpha-Tocopherol / Q000138:chemical synthesis* / Q000737:chemistry
D000975:Antioxidants; D002839:Chromans; D011392:Proline; D024502:alpha-Tocopherol