Interval growth of probably benign breast lesions on follow-up ultrasound: how can these be managed?
OBJECTIVE
To investigate the malignancy rate in probably benign lesions with interval growth on follow-up ultrasound (US) and the cut-off values for predicting malignancy.


METHODS
By retrospective reviewing 19,435 US examinations assessed as probably benign lesions, a total of 214 lesions with interval growth in 199 patients were included. The increased volume (%V),%V per month, the most increased diameter (D), and D per month were compared between malignant and benign lesions. Malignancy rates were compared between lesions with or without newly developed suspicious malignant features.


RESULTS
Twenty-two (10.3%) malignancies showed significant increase in%V,%V per month, D, and D per month compared with 192 (89.7%) benign lesions (p = 0.0083, <0.0001, <0.0001, and <0.0001, respectively). Fifteen (38.5%) of 39 lesions where suspicious features developed proved malignant, whereas 7 (4%) out of 175 without were malignant (p = 0.0011). In nodules without suspicious features, 24.2% of%V per month and 1.9 mm of D per month showed high sensitivity (85.7% and 71.4%) and specificity (67.8% and 97.6%) for predicting malignancy.


CONCLUSIONS
Probably benign lesions with interval growth should undergo prompt biopsy because of the 10.3% malignancy rate. In lesions where suspicious features developed, the malignancy rate increased to 38.5%.
Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, South Korea.
Hee Jung
HJ
Moon
Eun-Kyung
EK
Kim
Jin Young
JY
Kwak
Jung Hyun
JH
Yoon
Min Jung
MJ
Kim
D000328:Adult; D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D014463:Ultrasonography / Q000379:methods*; D016217:Ultrasonography, Mammary / Q000379:methods*