A 3-year- old girl with altered mental status, gait difficulty, and vomiting.
We report a case of a 3-year-old girl with a 9-month history of focal neurologic finding and signs of increased intracranial pressure. Radiological imaging studies showed a minimally heterogeneous enhancing large tumor involving left parietal region and partly filling the left lateral ventricle. Microscopically, the tumor contained prominent small true rosettes set into areas of fibrillar neuropil-like matrix. Foci of cellular tumor with extensive apoptosis were present. The neuropil-like areas and true rosettes were positive for synaptophysin immunostain. The tumor was negative for GFAP and neurofilament protein immunostains. MIB-1 proliferation index was high focally approaching 80%.
Ilya
I
Lim
Irina
I
Mikolaenko
Mark
M
Cohen
D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D051346:Mobility Limitation; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications / Q000473:pathology*; D019581:Neuropil / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology*; D014839:Vomiting / Q000209:etiology*