Karyotyping, is it worthwhile in transsexualism?
BACKGROUND
Karyotyping is often performed in transsexual individuals.


OBJECTIVE
Quantification and characterization of karyotype findings and abnormalities in transsexual persons.


METHODS
Karyotypes were listed both in male-to-female and in female-to-male transsexual persons.


METHODS
The data were collected through a retrospective study.


RESULTS
Karyotypes of 368 transsexual individuals (251 male-to-female, 117 female-to-male) are described. Normal findings were found in 97.55%. Prevalence of abnormal karyotypes was 3.19% among male-to-female, and 0.85% among female-to-male transsexuals. Nine karyotypes showed variations; Klinefelter syndrome was confirmed in three persons, whereas others displayed autosomal aberrations.


CONCLUSIONS
Karyotyping is only of very limited information in the transsexual population.
Department of Endocrinology-Andrology, Center for Sexology and Genderproblems, Ghent University Hospital, Ghent, Belgium.
Adrien
A
Inoubli
Griet
G
De Cuypere
Robert
R
Rubens
Gunter
G
Heylens
Els
E
Elaut
Eva
E
Van Caenegem
Björn
B
Menten
Guy
G
T'Sjoen
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D005783:Gender Identity; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations; D012737:Sex Factors; D014189:Transsexualism / Q000175:diagnosis / Q000235:genetics*