Past, present and future of human chromaffin cells: role in physiology and therapeutics.
Chromaffin cells are neuroendocrine cells mainly found in the medulla of the adrenal gland. Most existing knowledge of these cells has been the outcome of extensive research performed in animals, mainly in the cow, cat, mouse and rat. However, some insight into the physiology of this neuroendocrine cell in humans has been gained. This review summarizes the main findings reported in human chromaffin cells under physiological or disease conditions and discusses the clinical implications of these results.
Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, c/Arzobispo Morcillo 4, 28029 Madrid, Spain.
Alberto
A
Pérez-Alvarez
Alicia
A
Hernández-Vivanco
Almudena
A
Albillos
D000313:Adrenal Medulla / Q000166:cytology / Q000196:embryology / Q000637:transplantation; D019439:Chromaffin Cells / Q000502:physiology* / Q000637:transplantation*; D002837:Chromaffin Granules / Q000378:metabolism; D004194:Disease; D006801:Humans