Propylthiouracil-induced autoimmune syndromes: 11 case report.
The objective of this study was to report 11 cases of propylthiouracil (PTU)-induced autoimmune syndromes. We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had vasculitis and 4 patients had lupus. Patients with vasculitis were older and had a longer duration of treatment in comparison with lupus. P-ANCA were predominantly found in PTU-induced vasculitis, but also found in lupus, while ANA and anti-dsDNA were often found in lupus. Some difference of renal and pulmonary involvement was often found between PTU-induced vasculitis and lupus. Most of patients needed steroids or immunosuppressive drugs. Vasculitis in the cases of PTU-induced autoimmune phenomena is often found than lupus. P-ANCA in both PTU-induced lupus and vasculitis can all present, but there are differences in clinical and outcome features to diagnosis.
ChongQing Medical University, Chongqing, China. tcmclinic@163.com
Rui
R
Wu
Rongheng
R
Li
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D013956:Antithyroid Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects*; D013812:Therapeutics; D016896:Treatment Outcome; D014657:Vasculitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D055815:Young Adult
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011441:Propylthiouracil