Neuropathy with predominant small fiber involvement associated with abnormal anti-MAG titer.
We describe a patient with painful neuropathy associated with an abnormal anti-MAG titer in which predominant involvement of intra-epidermal nerve fiber was documented. Electrophysiological studies revealed low-borderline amplitude of sensory and compound motor action potentials registering from lower limbs and normal conduction velocity. Sural nerve biopsy disclosed only a slight loss of myelinated fiber. Skin biopsy performed at the proximal thigh and at the distal leg was consistent with a non-length-dependent small fiber neuropathy. It is likely that in this case anti-MAG antibodies played a role in the pathogenesis of small fiber neuropathy.
Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy. mluigetti@gmail.com
Marco
M
Luigetti
Francesca
F
Madia
Amelia
A
Conte
Pietro
P
Tonali
Mario
M
Sabatelli
D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D009413:Nerve Fibers, Myelinated / Q000276:immunology / Q000473:pathology*; D011115:Polyneuropathies / Q000175:diagnosis* / Q000276:immunology*
D001323:Autoantibodies; D018992:Myelin-Associated Glycoprotein