Two new antifungal cyclic lipopeptides from Bacillus marinus B-9987.
Two new cyclic lipopeptides maribasins A (1) and B (2) were isolated from the fermentation broth of the marine microorganism Bacillus marinus B-9987 isolated from Suaeda salsa in Bohai coastline of P. R. China. Both structures were established to be cyclo (D-Pro-L-Gln-L-Asn-L-Ser-D-Asn¹-D-Tyr-D-Asn²-D-β-aminoisopentadecanoic acid) (1) and cyclo (D-Pro-L-Gln-L-Asn-L-Ser-D-Asn¹-D-Tyr-D-Asn²-D-β-aminoanteisopentadecanoic acid) (2) by spectroscopic analysis and exhibited broad-spectrum activity against phytopathogens by the antifungal bioassay.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, PR China.
Dao-Jing
DJ
Zhang
Rong-Feng
RF
Liu
Yuan-Guang
YG
Li
Li-Ming
LM
Tao
Li
L
Tian
D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001407:Bacillus / Q000378:metabolism*; D055666:Lipopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic; C556720:maribasin A; C556721:maribasin B