Clinical and laboratory characteristics of patients with sickle-cell and autoimmune/connective tissue diseases.
Patients with sickle-cell disease who develop autoimmune connective tissue disorders can present with similar clinical manifestations and/or complications making them indistinguishable. We report here a single-institution study on a cohort of 24 patients, with the above combination. The results suggest that there is often a significant delay in making the second diagnosis because of the overlapping clinical profile. It is emphasized that the clinician should be aware of and vigilant about such cases and should diligently follow up such cases to make an early diagnosis and start the appropriate treatment.
Department of Haematology, Sultan Qaboos University, P.O. Box 35, Muscat 123, Sultanate of Oman. sskindi@yahoo.com
Salam
S
Alkindi
Mustafa
M
Al-Maini
Anil
A
Pathare
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D015331:Cohort Studies; D003240:Connective Tissue Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009850:Oman; D012189:Retrospective Studies; D055815:Young Adult