What determines the specificity and outcomes of ubiquitin signaling?
Ubiquitin signals and ubiquitin-binding domains are implicated in almost every cellular process, but how is their functionality achieved in cells? We assess recent advances in monitoring the dynamics and specificity of ubiquitin networks in vivo and discuss challenges ahead.
Frankfurt Institute for Molecular Life Sciences, Goethe University School of Medicine, Main, Germany.
Fumiyo
F
Ikeda
Nicola
N
Crosetto
Ivan
I
Dikic
D000818:Animals; D006801:Humans; D054730:Protein Interaction Domains and Motifs; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D025801:Ubiquitin / Q000737:chemistry / Q000378:metabolism*; D054875:Ubiquitination
D011506:Proteins; D025801:Ubiquitin