Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution.
Phosphodiesterase 10A (PDE10A) hydrolyzes both cAMP and cGMP, and is a key element in the regulation of medium spiny neuron (MSN) activity in the striatum. In the present report, we investigated the effects of targeted disruption of PDE10A on spatial learning and memory as well as aversive and appetitive conditioning in C57BL/6J mice. Because of its putative role in motivational processes and reward learning, we also determined the expression of the immediate early gene zif268 in striatum and anterior cingulate cortex. Animals showed decreased response rates in scheduled appetitive operant conditioning, as well as impaired aversive conditioning in a passive avoidance task. Morris water maze performance revealed not-motor related spatial learning and memory deficits. Anxiety and social explorative behavior was not affected in PDE10A-deficient mice. Expression of zif268 was increased in striatum and anterior cingulate cortex, which suggests alterations in the neural connections between striatum and anterior cingulate cortex in PDE10A-deficient mice. The changes in behavior and plasticity in these PDE10A-deficient mice were in accordance with the proposed role of striatal MSNs and corticostriatal connections in evaluative salience attribution.
Laboratory of Biological Psychology, Department of Psychology, University of Leuven, Tiensestraat 102, 3000 Leuven, Belgium. elisabeth.piccart@psy.kuleuven.be
Elisabeth
E
Piccart
Ilse
I
Gantois
Annelies
A
Laeremans
Ronald
R
de Hoogt
Theo
T
Meert
Greet
G
Vanhoof
Lutgarde
L
Arckens
Rudi
R
D'Hooge
D000704:Analysis of Variance; D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology; D001245:Association Learning / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D051766:Early Growth Response Protein 1 / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology*; D006179:Gyrus Cinguli / Q000378:metabolism / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D017072:Neostriatum / Q000378:metabolism / Q000502:physiology; D010727:Phosphoric Diester Hydrolases / Q000235:genetics / Q000502:physiology*; D012919:Social Behavior; D018709:Statistics, Nonparametric
D051766:Early Growth Response Protein 1; C486109:Egr1 protein, mouse; C492284:Pde10a protein, mouse; D010727:Phosphoric Diester Hydrolases