[Usefulness of antimitochondrial antibody 113-1 in diagnosis and classification of salivary gland tumours with oncocytic differentiation].
OBJECTIVE
Salivary gland tumours usually show great variability both in their morphopathology as well as their clinical behaviour. In the present study, the usefulness of antimitochondrial monoclonal antibody 113-1 in the diagnosis and categorization of salivary tumours was studied.


METHODS
A series of 22 benign and malignant salivary tumours and 5 non-tumoral salivary gland specimens were immunohistochemically analysed using an antimitochondrial monoclonal antibody (Ab Mo 113-1), which recognises a non-glycosylated mitochondrial protein of 60 Kd.


RESULTS
The use of this antibody allowed us to recognize all salivary tumours with oncocytic differentiation. Two salivary tumours (1 papillary cystadenoma and 1 epithelial-myoepithelial carcinoma) (2/22; 10%) were also reclassified as oncocytic tumoral subtypes, in principle unidentified.


CONCLUSIONS
Our study highlights the usefulness of this antibody to facilitate the classification of salivary tumours, an aspect that may sometimes have not only diagnostic implications, but also prognostic.
Departamento de Patología, Universidad de Valencia, Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia, España. fco.jose.vera@uv.es
Francisco
F
Vera-Sempere
Beatriz
B
Vera-Sirera
D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000145:classification* / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal