Asymmetric dimethylarginine in ELBW newborns exposed to chorioamnionitis.
We measured circulating ADMA concentrations in a group of very premature newborns at birth and during the first week of life. ADMA levels resulted significantly higher in infants born to mothers with histologic chorioamnionitis than in infants delivered for other maternal or fetal indications, both at birth and through the first week of life. We speculate that ADMA might be involved in the complex biological events associated with fetal exposure to chorioamnionitis.
Neonatal Intensive Care Unit, Dept. of Pediatrics, University of Padova, Italy. michela.alfierobordigato@unipd.it
Michela
M
Alfiero Bordigato
Daniele
D
Piva
Iole Maria
IM
Di Gangi
Giuseppe
G
Giordano
Lino
L
Chiandetti
Marco
M
Filippone
D001120:Arginine / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D002821:Chorioamnionitis / Q000097:blood / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D052577:Infant, Extremely Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D008297:Male; D009994:Osmolar Concentration; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000276:immunology / Q000473:pathology
C018524:N,N-dimethylarginine; D001120:Arginine