Outcome of pregnancies in women with thrombophilic disorders.
Women with thrombophilic disorders may have pregnancy complications including fetal loss (FL); however, the impact of thromboprophylaxis with low molecular weight heparin (LMWH) and previous obstetric history remains to be clarified. Our aim was to compare the effects of LMWH in three groups of women with thrombophilia who had varying numbers of prior fetal losses. We prospectively investigated the live birth rates in 66 women with thrombophilic conditions, treated with a LMWH (enoxaparin, 40 mg daily). Groups 1, 2 and 3 included patients with 0-1, 2-3 and ≥ 4 pregnancy losses, respectively. Groups 1, 2 and 3 had 90.47%, 83.78% and 50.00% live birth frequencies, respectively. Group 3 had a significantly lower chance of a live birth compared with Group 1, regardless of type of thrombophilic disorder. FL aetiology in thrombophilic patients with multiple miscarriages appears multifactorial, and thromboprophylaxis alone may not be sufficient.
Department of Perinatology, Zekai Tahir Burak Women’s Health and Research Hospital, Ankara, Turkey. drsucak@yahoo.com
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D000026:Abortion, Habitual / Q000188:drug therapy / Q000209:etiology*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D005313:Fetal Death / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D050498:Live Birth; D011247:Pregnancy; D019851:Thrombophilia / Q000150:complications* / Q000188:drug therapy; D055815:Young Adult
D000925:Anticoagulants; D017984:Enoxaparin