An artificial sperm--next year or never?
The idea that a sperm or egg might be formed outside of a gonad is perhaps as bizarre today as human assisted conception and test-tube babies were 30-40 years ago and has received a similar amount of media copy. Here, we review briefly the derivation of mammalian germ cells and sperm cells from embryonic stem cells in vitro, ask whether these methods are viable and could provide therapies in the future, and discuss what constitutes an 'artificial' sperm.
Department of Biomedical Science, Centre for Stem Cell Biology, University of Sheffield, Western Bank, Sheffield, UK.
Muhammad
M
Lokman
Harry
H
Moore
D000818:Animals; D001187:Artificial Organs; D053595:Embryonic Stem Cells; D005718:Gametogenesis; D006801:Humans; D008297:Male; D008540:Meiosis; D051379:Mice; D010641:Phenotype; D013094:Spermatozoa