Alternative strategy for adjusting the association specificity of hydrogen-bonded duplexes.
A strategy for creating new association specificity of hydrogen-bonded duplexes by varying the spacings between neighboring hydrogen bonds is described. Incorporation of naphthalene-based residues has provided oligoamide strands that pair into duplexes sharing the same H-bonding sequences (e.g., DDAA) but differing in the spacings between their intermolecular hydrogen bonds, leading to homo- or heteroduplexes. The ability to manipulate association-specificity as demonstrated by this work may be extended to other multiple hydrogen bonded systems, thereby further enhancing the diversity of multiple hydrogen-bonded association units for constructing supramolecular structures.
College of Chemistry, Key Laboratory for Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Analytical & Testing Center of Sichuan University, Sichuan University, Chengdu 610064, China.
Penghui
P
Zhang
Hongzhu
H
Chu
Xianghui
X
Li
Wen
W
Feng
Pengchi
P
Deng
Lihua
L
Yuan
Bing
B
Gong