Vascular endothelial growth factor +936 C/T gene polymorphism and glioma risk in a Chinese Han population.
BACKGROUND
Angiogenesis plays an important role in tumor progression. The vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis.


OBJECTIVE
The objective of this study was to investigate the association between VEGF +936 C/T gene polymorphism and glioma risk in a Chinese Han population.


METHODS
We extracted the peripheral blood samples in 160 glioma patients and 320 controls. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism method.


RESULTS
Glioma patients had a significantly higher frequency of TT genotype (odds ratio [OR] = 3.75, 95% confidence interval [CI] = 1.24, 11.40; p = 0.02) than controls. Glioblastoma patients had a significantly higher frequency of TT genotype (OR = 3.05, 95% CI = 1.11, 8.37; p = 0.03) than other gliomas. Patients with grade IV glioma had a significantly higher frequency of TT genotype (OR = 3.12, 95% CI = 1.14, 8.58; p = 0.03) than low-grade glioma.


CONCLUSIONS
Our study indicated that VEGF + 936 C/T genotype was associated with a higher glioma risk in a Chinese Han population.
Department of Neurosurgery, The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China. gangbao73@hotmail.com
Gang
G
Bao
Maode
M
Wang
Shiwen
S
Guo
Yuliang
Y
Han
Gaofeng
G
Xu
D000328:Adult; D044466:Asian People; D002681:China / Q000208:ethnology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D005910:Glioma / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A