Incorporation of organometallic Ru complexes into apo-ferritin cage.
Spherical protein cages such as an iron storage protein, ferritin, have great potential as nanometer-scale capsules to assemble and store metal ions and complexes. We report herein the synthesis of a composite of an apo-ferritin cage and Ru(p-cymene) complexes. Ru complexes were efficiently incorporated into the ferritin cavity without degradation of its cage structure. X-Ray crystallography revealed that the Ru complexes were immobilized on the interior surface of the cage mainly by the coordination of histidine residues.
Research Center for Materials Science, Nagoya University, Furo-cho, Nagoya, Japan.
Yusuke
Y
Takezawa
Philipp
P
Böckmann
Naoki
N
Sugi
Ziyue
Z
Wang
Satoshi
S
Abe
Tatsuya
T
Murakami
Tatsuo
T
Hikage
Gerhard
G
Erker
Yoshihito
Y
Watanabe
Susumu
S
Kitagawa
Takafumi
T
Ueno
D019943:Amino Acid Substitution; D001052:Apoferritins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D056831:Coordination Complexes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006639:Histidine / Q000737:chemistry; D009154:Mutation; D017434:Protein Structure, Tertiary; D012428:Ruthenium / Q000737:chemistry*
D056831:Coordination Complexes; D006639:Histidine; D012428:Ruthenium; D001052:Apoferritins