Signaling of interleukin-17 family cytokines in immunity and inflammation.
IL-17 cytokine family, though still young since discovery, has recently emerged as critical players in immunity and inflammatory diseases. The prototype cytokine, IL-17A, plays essential roles in promoting inflammation and host defense. IL-17RA, a member of the IL-17 receptor family, forms a complex with another member, IL-17RC, to mediate effective signaling for IL-17A as well as IL-17F, which is most similar to IL-17A, via Act1 and TRAF6 factors. On the other hand, IL-17RA appears to interact with IL-17RB to regulate signaling by another cytokine IL-25. IL-25, the most distant from IL-17A in the IL-17 family, is involved in allergic disease and defense against helminthic parasites. In this review, we discuss recent advancements on signaling mechanisms and biological functions of IL-17A, IL-17F and IL-25, which will shed light on the remaining IL-17 family cytokines and help understand and treat inflammatory diseases.
Department of Immunology and Center for Inflammation and Cancer, M D Anderson Cancer Center, Houston, TX, USA.
Seon Hee
SH
Chang
Chen
C
Dong
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001854:Bone Marrow Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D017434:Protein Structure, Tertiary; D018123:Receptors, Interleukin / Q000378:metabolism; D015398:Signal Transduction; D048029:TNF Receptor-Associated Factor 6 / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D020381:Interleukin-17; D016328:NF-kappa B; D018123:Receptors, Interleukin; D048029:TNF Receptor-Associated Factor 6; C414202:TRAF3IP2 protein, human; D014157:Transcription Factors; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D020928:Mitogen-Activated Protein Kinases