Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue.
Schisandrin B (Sch B) and schisandrin C (Sch C), but not schisandrin A and dimethyl diphenyl bicarboxylate, protected rat skin tissue against solar irradiation-induced oxidative injury, as evidenced by a reversal of solar irradiation-induced changes in cellular reduced glutathione and α-tocopherol levels, as well as antioxidant enzyme activities and malondialdehyde production. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production in rat skin microsomes. Taken together, Sch B or Sch C, by virtue of its pro-oxidant action and the subsequent eliciting of a glutathione antioxidant response, may prevent photo-aging of skin.
Division of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China.
Philip Y
PY
Lam
Chung Wai
CW
Yan
Po Yee
PY
Chiu
Hoi Yan
HY
Leung
Kam Ming
KM
Ko
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D034242:Cyclooctanes / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D017705:Lignans / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011083:Polycyclic Compounds / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D032141:Schisandra / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D013472:Sunlight / Q000009:adverse effects; D024502:alpha-Tocopherol / Q000378:metabolism
D000975:Antioxidants; D034242:Cyclooctanes; D017705:Lignans; D010936:Plant Extracts; D011083:Polycyclic Compounds; C015499:schizandrin B; D008315:Malondialdehyde; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; D024502:alpha-Tocopherol