Paraoxonase 1 gene and glutathione S-transferase μ 1 gene interaction with preterm delivery in Korean women.
OBJECTIVE
This study was undertaken to identify the paraoxonase 1 gene and glutathione S-transferase μ 1 gene interaction for the risk of preterm delivery and to determine the serum paraoxonase activity according to paraoxonase 1 genotypes.


METHODS
This case-control study was performed on 162 gravida women with preterm delivery and 306 controls. Serum paraoxonase activity was measured by a ultraviolet spectrophotometer. Logistic regression, 2-way analysis of variance, and multifactor dimensionality reduction analysis were used.


RESULTS
Gravida women with the QQ and QR genotype of paraoxonase 1 with high body mass index had 6.19- and 4.41-fold increased risks of preterm delivery. The glutathione S-transferase μ 1 null genotype and the interaction between the paraoxonase 1 genotype and glutathione S-transferase μ 1 null type conferred a risk for preterm delivery. Serum paraoxonase activity was significantly different according to paraoxonase 1 genotypes (P < .0001).


CONCLUSIONS
The glutathione S-transferase μ 1 null genotype confers a risk for preterm delivery in Korean gravida women independent of and interactive with the paraoxonase 1 genotype.
Department of Preventive Medicine, Ewha Womans University, Seoul, Korea.
Bo Eun
BE
Lee
Hyesook
H
Park
Eun Ae
EA
Park
Hyesun
H
Gwak
Eun Hee
EH
Ha
Myung-Geol
MG
Pang
Young Ju
YJ
Kim
D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D005865:Gestational Age; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007723:Korea; D016015:Logistic Models; D015999:Multivariate Analysis; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D005982:Glutathione Transferase; D043303:Aryldialkylphosphatase