The relationship between serum thyrotropin and components of metabolic syndrome.
To explore the relationship between serum thyrotropin and components of metabolic syndrome in a Chinese cohort. A total of 1534 adult inhabitants in DaDong district of Shenyang were asked to fulfill the questionnaire, complete physical examination and OGTT. Blood samples were collected to test thyrotropin (TSH), fasting plasma glucose (FPG), OGTT 2h PG, fasting insulin (FINS), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C). Serum TSH in metabolic syndrome group was higher than that in the non-metabolic syndrome group (2.54 mIU/L vs. 2.22 mIU/L, p<0.05). TG level increased significantly in subclinical hypothyroid group compared with euthyroid subjects (1.73±0.12 mmol/L vs. 1.47±0.03 mmol/L, p<0.05), and HDL-C decreased significantly in patients with subclinical hypothyroidism compared with euthyroid subjects (1.26±0.27 mmol/L vs. 1.33±0.27 mmol/L, p<0.05). The prevalence of hypertension was higher in the subclinical hypothyroid group than that in euthyroid group (42.86% vs. 33.2%, p<0.05). The serum TSH within the reference range was positively related with the prevalence of overweight/obesity. Slight increase in serum TSH maybe a risk factor for metabolic syndrome.
Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping, Shenyang, China.
Yaxin
Y
Lai
Jiani
J
Wang
Fengwei
F
Jiang
Beibei
B
Wang
Yanyan
Y
Chen
Mengchun
M
Li
He
H
Liu
Chenyan
C
Li
Haibo
H
Xue
Ningna
N
Li
Jiashu
J
Yu
Liangfeng
L
Shi
Xue
X
Bai
Xin
X
Hou
Lin
L
Zhu
Li
L
Lu
Sen
S
Wang
Qian
Q
Xing
Xiaochun
X
Teng
Weiping
W
Teng
Zhongyan
Z
Shan
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D006980:Hyperthyroidism / Q000175:diagnosis; D007037:Hypothyroidism / Q000175:diagnosis; D007328:Insulin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D050177:Overweight; D015995:Prevalence; D013972:Thyrotropin / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides; D013972:Thyrotropin