Fabrication of magnetite-hydrogel nanocomposites with clustered magnetite cores and poly(N-isopropylacrylamide-co-acrylic acid) shells for drug delivery application.
Magnetite-hydrogel nanocomposites were fabricated through the combination of sol-gel process and radical polymerization. The incorporation of magnetite clusters into silica matrix was facilely conducted by the sol-gel reaction of APTMS-complexed CMNPs (citrate-stabilized magnetites) and tetraethoxysilane (TEOS) in ethanol solution. The core-shell magnetic nanoparticles were further encapsulated with poly(N-isopropylacrylamide-co-acrylic acid) hydrogeals via a free radical polymerization. The magnetic nanoparticles exhibited superparamagnetic characteristics with negligible remanence and coercivity. Hydrogel-encapsulated magnetic nanoparticles showed systematic changes of particle size corresponding to the alteration of pH and temperature. The resulting nanocomposites can be a smart drug delivery agent with magnetic and stimuli (pH, temperature)-sensitive properties.
Department of Chemical and Bio Engineering, Kyungwon University, San 65 Bokjeong-dong, Soojung-gu, Seongnam-si, Gyeonggi-do, 461-701, South Korea.
Sera
S
Lim
Daniel
D
Yang
Sang-Wha
SW
Lee
D000178:Acrylamides / Q000737:chemistry*; D000179:Acrylates / Q000737:chemistry*; D016503:Drug Delivery Systems; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning
D000178:Acrylamides; D000179:Acrylates; D020100:Hydrogels; C067295:N-isopropylacrylamide; D052203:Ferrosoferric Oxide