Adverse events in therapeutic apheresis: a single center survey of various therapies.
The aim of the study was to review the adverse events associated with various treatment modalities performed in a single apheresis facility. A total of 854 sessions with 10 types of apheresis therapies were performed and 154 (18.0%) adverse events were observed over a four-year period. Of the adverse events, 77 were related to operational problems and another 77 were complications associated with treatment. A transmembranous pressure abnormality constituted more than 80% of the operational problems. Nausea was the most frequent complication, accounting for 19 of the 77 treatment-related events. A total of 26 (16.9%) adverse events occurred in the early stage of the sessions, 40 (26.0%) in the middle stage, and 88 (57.1%) in the late stage. The information in this study can be used to improve the safety and efficacy of apheresis therapy.
Department of Clinical Engineering, Osaka Red Cross Hospital, Osaka, Japan. takeshi_1485@yahoo.co.jp
Takeshi
T
Ishihara
Satoko
S
Inoue
Yukiko
Y
Takagi
Taro
T
Shimomura
Yoshiaki
Y
Sagami
Sayomi
S
Katayama
Yoko
Y
Eguchi
Kenji
K
Watase
Masahiko
M
Miyamoto
Tamotsu
T
Minakata
D001781:Blood Component Removal / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007564:Japan; D007937:Leukapheresis / Q000379:methods*; D009325:Nausea / Q000453:epidemiology / Q000209:etiology*; D013997:Time Factors