Benign fibrous histiocytoma of the lower lip.
Benign fibrous histiocytoma (BFH) is one of the most common tumors of the superficial and deep soft tissues; it is commonly localized on the skin of the extremities and presents as a slow growing solitary nodule, made up of a mixture of fibroblastic and histiocytic cells. To our knowledge, involvement of the soft tissue of the oral cavity is rare. We present a case of BFH of the lower lip in a 61-year-old white woman who presented with a painless, slow-growing lump inside the lower lip. The lesion was surgically removed. Histologically, it was characterized by uniform spindle-shaped cells arranged in a prominent whorled or storiform pattern. Scattered xanthomatous cells, multinucleated giants cells, lymphocytes, and deposits of hemosiderin were noted throughout the lesion. This rare tumor should be considered in the differential diagnosis of the oral soft-tissue neoplasms.
Department of Clinical and Experimental Medicine, University of Eastern Piedmont Amedeo Avogadro, Novara, Italy. mario.migliario@med.unipmn.it
Mario
M
Migliario
Lia
L
Rimondini
Guido
G
Valente
D018263:Adenocarcinoma, Follicular / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D015726:Giant Cells / Q000473:pathology; D006485:Hemosiderin / Q000032:analysis; D006644:Histiocytes / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis*; D006801:Humans; D008048:Lip Neoplasms / Q000175:diagnosis*; D008214:Lymphocytes / Q000473:pathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis; D013964:Thyroid Neoplasms / Q000473:pathology
D006485:Hemosiderin