B7-h3 and its role in antitumor immunity.
B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.
Chirurgische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische Universität München, Germany.
Martin
M
Loos
Dennis M
DM
Hedderich
Helmut
H
Friess
Jörg
J
Kleeff
D015703:Antigens, CD / Q000276:immunology / Q000627:therapeutic use; D060887:B7 Antigens; D014408:Biomarkers, Tumor / Q000276:immunology / Q000627:therapeutic use; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D005260:Female; D006801:Humans; D056747:Immunomodulation; D008213:Lymphocyte Activation / Q000276:immunology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D011971:Receptors, Immunologic / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D016019:Survival Analysis; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D015703:Antigens, CD; D060887:B7 Antigens; D014408:Biomarkers, Tumor; C423237:CD276 protein, human; D016207:Cytokines; D011971:Receptors, Immunologic