Quantitative assessment of neurons and neuroglia with computer morphometry.
The morphology of neural and glial cells in different cerebral areas and in various experimental models was quantitatively studied by methods of computer morphometry combined with video image analysis systems. The following parameters were obtained: density of neurons and glial cells per 1 mm(2), number of satellite perineuronal glial cells, aspect ratio for neural and glial cells, the area occupied by neuroglial projections, etc. The tested computer morphometry methods can be efficient in quantitative assessment of pathological and regenerative processes in the nervous tissue.
Laboratory of Functional Morphochemistry, Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia. rolfbrain@yandex.ru
R M
RM
Khudoerkov
D N
DN
Voronkov
D000818:Animals; D002452:Cell Count; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006168:Guinea Pigs; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D010784:Photomicrography; D051381:Rats
D005904:Glial Fibrillary Acidic Protein