N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides.
N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.
Westfälische Wilhelms-Universität, NRW Graduate School of Chemistry, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.
Mohan
M
Padmanaban
Akkattu T
AT
Biju
Frank
F
Glorius