Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis.
Inhibitory effects of HL-n composed of 95 mol% L-α-dimyristoylphosphatidylcholin (DMPC) and 5 mol% polyoxyethylenedodecylether (C(12)(EO)(n), n = 21, 23, or 25) on the growth of human rheumatoid arthritis (RA) fibroblast-like synoviocytes (HFLS-RA) in vitro were examined. Remarkably high inhibitory effects of HL-n on the growth of HFLS-RA cells were obtained. The induction of apoptosis by HL-n was revealed on the basis of TUNEL method. Furthermore, the therapeutic effects of HL-23 using mouse models of arthritis were investigated. Therapeutic effects without joint swelling were obtained in mouse models of RA treated with HL.
Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan.
Hideaki
H
Ichihara
Motoki
M
Hino
Taku
T
Makizono
Masayo
M
Umebayashi
Yoko
Y
Matsumoto
Ryuichi
R
Ueoka
D000818:Animals; D017209:Apoptosis; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D004195:Disease Models, Animal; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000737:chemistry; D013583:Synovial Membrane / Q000166:cytology*
D008081:Liposomes; D000077423:Polidocanol; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine