Care required when using bisphosphonates in dental surgical practice.
Bisphosphonates are pharmacologic compounds characterized by high tropism to bone tissue. They affect bone metabolism by inhibition of osteoclast recruitment, proliferation, differentiation, and function. Because they can reduce bone resorption, bisphosphonates are used mainly for the treatment of osteometabolic conditions. However, the use of bisphosphonates has been associated with the onset of osteonecrosis of the jaws and indication of dental implants. As a result of this, the aim of this study was to present the risks and the care that health professionals should take in cases of surgical procedures such as placement of dental implants in patients who make use of bisphosphonates.
Department of Dental Materials and Prosthodontics, University of the State of São Paulo, Brazil. goiato@foa.unesp.br
Marcelo Coelho
MC
Goiato
Daniela Micheline
DM
dos Santos
Bruna Carolina Santos
BC
Rondon
Amália
A
Moreno
Gabriella Trunkcle
GT
Baptista
Fellippo Ramos
FR
Verri
Stefan Fiuza de Carvalho
SF
Dekon
D000284:Administration, Oral; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016723:Bone Remodeling / Q000187:drug effects; D003758:Dental Implantation, Endosseous; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D007571:Jaw Diseases / Q000139:chemically induced / Q000628:therapy; D019647:Oral Surgical Procedures; D010020:Osteonecrosis / Q000139:chemically induced / Q000628:therapy; D018570:Risk Assessment
D050071:Bone Density Conservation Agents; D004164:Diphosphonates