CB-1 antagonism with LY2190416 results in acute weight loss in obese adult dogs fed a high-fat diet.
Elanco Animal Health, 2500 Innovation Way Greenfield, IN 46140, USA. newhallkb@lilly.com
K
K
Newhall
E
E
Nunamaker
S
S
Gissendanner
C
C
Thompson
J
J
Owens
A
A
Lucas
J G
JG
Sherman
D000818:Animals; D004032:Diet / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004435:Eating / Q000187:drug effects; D005223:Fats / Q000008:administration & dosage; D005260:Female; D007211:Indoles / Q000627:therapeutic use; D008297:Male; D009765:Obesity / Q000188:drug therapy / Q000662:veterinary*; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors*; D015431:Weight Loss / Q000187:drug effects
D005223:Fats; D007211:Indoles; C556562:LY2190416; D043884:Receptor, Cannabinoid, CB1