Emergence of VIM-1 metallo-β-lactamase-producing Escherichia coli in a neonatal intensive care unit.
A carbapenem-resistant Escherichia coli isolate was recovered from rectal swab of a 12-day-old female neonate, which was admitted to a Greek neonatal intensive care unit (NICU). Phenotypic testing, polymerase chain reaction assays with sequencing, and plasmid analysis revealed that the isolate harbored a plasmid-mediated bla(VIM-1) metallo-β-lactamase gene. The appearance of a metallo-β-lactamase-producing E. coli in NICU is worrisome. Further surveys are needed to determine whether such Enterobacteriaceae may also be spreading in other NICUs.
Department of Microbiology, Aglaia Kyriakou Children's Hospital, Athens, Greece.
Maria
M
Papadimitriou
Evangelia
E
Voulgari
Kyriaki
K
Ranellou
Evangelia
E
Koemtzidou
Evangelia
E
Lebessi
Athanassios
A
Tsakris
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006115:Greece; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D010957:Plasmids; D016133:Polymerase Chain Reaction; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics
D000900:Anti-Bacterial Agents; D015780:Carbapenems; C417264:VIM-1 metallo-beta-lactamase; D001618:beta-Lactamases