Ran control of mitosis in human cells: gradients and local signals.
Roles of the GTPase Ran in cell life and division rely on a largely conserved mechanism, i.e. Ran's ability to interact with transport vectors. Modes of control of downstream factors, however, are diversified at particular times of the cell cycle. Specificity and fine-tuning emerge most clearly during mitosis. In the present article, we focus on the distinction between global mitotic control by the chromosomal Ran gradient and specific spatial and temporal control operated by localized Ran network members at sites of the mitotic apparatus in human cells.
IBPM Institute of Molecular Biology and Pathology, CNR National Research Council, c/o Sapienza University of Rome, 00185 Rome, Italy.
Emanuele
E
Roscioli
Alessio
A
Bolognesi
Giulia
G
Guarguaglini
Patrizia
P
Lavia
D000818:Animals; D006801:Humans; D028884:Karyopherins / Q000235:genetics / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D009865:Oocytes / Q000502:physiology; D020931:ran GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*
D028884:Karyopherins; D020931:ran GTP-Binding Protein