A practical, one-pot synthesis of sulfonylated pyridines.
A concise and efficient one-pot synthesis of functionalized sulfonylated pyridines via an S(N)Ar reaction of readily available pyridines and sodium sulfinate salts in the presence of tetrabutylammonium chloride is presented.
Department of Process Research, Merck & Co., Inc., Rahway, New Jersey 07065, United States. kevin_maloney@merck.com
Kevin M
KM
Maloney
Jeffrey T
JT
Kuethe
Kathleen
K
Linn
D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis*; D013450:Sulfones / Q000737:chemistry*
D011725:Pyridines; D013450:Sulfones