[Alzheimer's disease and anaesthesia: potential relationships and clinical implications].
Alzheimer's disease is the most common form of dementia. As the aging population increases, Alzheimer's disease is becoming a major concern of Public Health. Many molecular lesions have been detected in Alzheimer's disease, but physiopathology is still poorly understood. If the neurotoxicity of anaesthetics in human remains debatable, perioperative period is certainly a high-risk factor for cognitive impairment, especially in elderly population. Large clinical studies are required to develop new strategies for perioperative management in such patients, including the adjustment of anaesthesia techniques. Before that, information of patient and its relatives and a particular attention for elderly during anaesthesia and perioperative period should be considered.
Service d'anesthésie réanimation I, groupe hospitalier Pellegrin, CHU de Bordeaux, université Victor-Segalen Bordeaux 2, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France.
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D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D000758:Anesthesia / Q000009:adverse effects; D000777:Anesthetics; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D019990:Perioperative Care; D011183:Postoperative Complications / Q000523:psychology
D000777:Anesthetics