Vancomycin-functionalised Ag@TiO2 phototoxicity for bacteria.
This study reports on the synthesis of vancomycin (Van)-functionalised Ag@TiO(2) nanoparticles and their enhanced bactericidal activities. Van-Ag@TiO(2) nanoparticles were prepared by nanoparticle deposition and chemical cross-linking reactions. The catalysts showed high efficiency for the degradation of methylene blue under ultraviolet (UV) illumination. The photocatalytic inactivation of the sulphate-reducing bacteria, Desulfotomaculum, was also studied under UV light irradiation and in the dark using aqueous mixtures of Ag, Ag@SiO(2), Ag@TiO(2), and Van-Ag@TiO(2). The Van-Ag@TiO(2) nanoparticles showed a capacity to target Van-sensitive bacteria. They also effectively prevented bacterial cell growth through the functionalised nanoparticles under UV irradiation for 1h. To investigate the specificity of the catalyst phototoxicity, a Van-resistant bacteria, Vibrio anguillarum, was used as the negative control. The results indicated that Van-Ag@TiO(2) nanoparticles had a higher selective phototoxicity for Van-sensitive bacteria. Therefore, the antibiotic molecule-functionalised core-shell nanoparticles allow for selective photokilling of pathogenic bacteria.
Chinese Academy of Sciences, Key Laboratory of Corrosion Science, Shandong Province, Institute of Oceanology, Qingdao, China.
Yi
Y
Wan
Dun
D
Zhang
Yi
Y
Wang
Peng
P
Qi
Jiajia
J
Wu
Baorong
B
Hou
D002384:Catalysis; D045859:Desulfotomaculum / Q000187:drug effects* / Q000528:radiation effects; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D008826:Microbial Sensitivity Tests; D014025:Titanium / Q000737:chemistry / Q000633:toxicity*; D014466:Ultraviolet Rays; D014640:Vancomycin / Q000737:chemistry*
C009495:titanium dioxide; D014640:Vancomycin; D006046:Gold; D014025:Titanium