Mechanisms of toxic effect of streptozotocin on β-cells in the islets of langerhans.
Administration of streptozotocin caused selective damage to endocrine β-cells in rat pancreatic islets, which was related to activation of apoptosis. The cytotoxic effect of streptozotocin was associated not only with DMA damage due to dysfunction of the antioxidant defense system, but also with activation of the caspase cascade and TNF-related apoptosis-inducing ligand.
Department of Pathological Anatomy, Russian Research Institute of Health, Moscow, Russia.
V B
VB
Pisarev
G L
GL
Snigur
A A
AA
Spasov
M P
MP
Samokhina
A E
AE
Bulanov
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D020169:Caspases / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D007515:Islets of Langerhans / Q000166:cytology*; D051381:Rats; D013311:Streptozocin / Q000633:toxicity*
D013311:Streptozocin; D020169:Caspases