Odd-numbered oxacalix[n]arenes (n = 5, 7): synthesis and solid-state structures.
The critical synthetic access to odd-numbered calix[n]arenes has evidently resulted in less attention for these macrocycles, although specific molecular recognition phenomena have been observed for some of them. A straightforward fragment coupling approach has been designed, applying kinetically controlled nucleophilic aromatic substitution reaction conditions, affording odd-numbered oxacalix[n]arenes (n = 5, 7) selectively in high yields. The solid-state conformational behavior and the oxacalix[n]arene cavity size were explored by single-crystal X-ray diffraction studies.
Molecular Design and Synthesis, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
Wim
W
Van Rossom
Koen
K
Robeyns
Magriet
M
Ovaere
Luc
L
Van Meervelt
Wim
W
Dehaen
Wouter
W
Maes