The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat.
BACKGROUND
This study was conducted to evaluate the effect of interaction of sympathetic and opioid systems in the processing of polycystic ovary syndrome modeling in rat.


METHODS
Ninety adult female rats (7-8 weeks of age) were treated with EV for 60 days for induction of follicular cysts (PCO modeling). Clonidine and yohimbine were used for sympathic agonist and antagonist and nalterxone was used for opioid system inhibition. Interactions of two systems were studied.


RESULTS
Our results indicate that both systems and interaction of two systems are effective in processing modeling of PCOS in rat. Interaction of two system drugs decreased estradiol (P < 0.05). Qualitative analysis showed that the bulk of cysts and corpus lutea and dominant follicles were increased in PCO rats in comparison with control group.


CONCLUSIONS
Therefore there could been an alternative in the treatment of the polycystic ovary syndrome in the rat by using adrenergic agonist and antagonists in combination with naltrexone.
Vali-e-Asr, Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran. Zangeneh14@gmail.com
Farideh Zafari
FZ
Zangeneh
A
A
Mohammadi
Sh
Sh
Ejtemaeimehr
Mohammad Mahdi
MM
Naghizadeh
Aminee
A
Fatemeh
D058647:Adrenergic alpha-2 Receptor Agonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000818:Animals; D003000:Clonidine; D004195:Disease Models, Animal; D004958:Estradiol / Q000031:analogs & derivatives; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D009271:Naltrexone; D009292:Narcotic Antagonists; D010053:Ovary / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism*; D015016:Yohimbine
D058647:Adrenergic alpha-2 Receptor Agonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D012739:Gonadal Steroid Hormones; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D015016:Yohimbine; D004958:Estradiol; D009271:Naltrexone; D003000:Clonidine