3-Hydroxymethylglutaryl flavonol glycosides from a Mongolian and Tibetan medicine, Oxytropis racemosa.
Three new flavonol 3-O-glycosides, rhamnetin 3-O-[(S)-3-hydroxy-3-methyl-glutaroyl(1→6)]-β-D-glucopyranoside (1), rhamnocitrin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-β-D-glucopyranoside (2), and isorhamnetin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside (3), along with 13 known compounds, were isolated from Oxytropis racemosa TURCZ. Their structures were deduced by means of spectroscopic methods and chemical evidence. 2 and 6 showed cytotoxic activities against HCT-8 (IC₅₀ 6.38 µM) and A549 (IC₅₀ 5.20 µM), respectively.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College.
Shuang
S
Song
Xiuping
X
Zheng
Weidong
W
Liu
Ruifang
R
Du
Lifu
L
Bi
Peicheng
P
Zhang
D045744:Cell Line, Tumor; D044948:Flavonols / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D008986:Mongolia; D033021:Oxytropis / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D018609:Tibet
D044948:Flavonols; D006027:Glycosides; C556719:isorhamnetin 3-O-((S)-3-hydroxy-3-methylglutaroyl(1-6))-alpha-L-rhamnopyranosyl(1-2)-beta-D-glucopyranoside; C556717:rhamnetin 3-O-((S)-3-hydroxy-3-methylglutaroyl(1-6))-beta-D-glucopyranoside; C556718:rhamnocitrin 3-O-((S)-3-hydroxy-3-methylglutaroyl(1-6))-beta-D-glucopyranoside