Toward a structural understanding of arf family:effector specificity.
Arf family proteins are critical regulators of intracellular trafficking and actin cytoskeleton dynamics. To carry out their cellular functions, Arf family proteins interact with various effectors that differ in nature and structure. Understanding how these proteins interact with structurally different partners and are distinguished by specific effectors while being closely related requires a structural characterization and comparison of the various Arf family:effector complexes. Recent structural reports of Arf and Arl proteins in complex with different downstream effectors shed new light on general and specific structural recognition determinants characteristic of Arf family proteins.
Institut Curie, Centre de Recherche, Paris F-75248, France. philippe.chavrier@curie.fr
Philippe
P
Chavrier
Julie
J
Ménétrey
D020727:ADP-Ribosylation Factors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D005810:Multigene Family; D011487:Protein Conformation; D021381:Protein Transport; D013379:Substrate Specificity
D008565:Membrane Proteins; C097313:ADP-ribosylation factor related proteins; D020727:ADP-Ribosylation Factors