Preventing erosion with novel agents.
OBJECTIVE
This in vitro study aimed to investigate the protective effect of four commercial novel agents against erosion.


METHODS
Ninety human molars were distributed into 9 groups, and after incubation in human saliva for 2 h, a pellicle was formed. Subsequently, the specimens were submitted to demineralization (orange juice, pH 3.6, 3 min) and remineralization (paste slurry containing one of the tested novel agents, 3 min) cycles, two times per day, for 4 days. The tested agents were: (1) DenShield Tooth; active ingredient: 7.5% W/W NovaMin(®) (calcium sodium phosphosilicate); (2) Nanosensitive hca; active ingredient: 7.5% W/W NovaMin(®); (3) GC Tooth Mousse; active ingredient: 10% Recaldent™ (CPP-ACP); (4) GC MI Paste Plus; active ingredients: 10% Recaldent™, 900 ppm fluoride. Two experimental procedures were performed: in procedure 1, the tested agents were applied prior to the erosive attack, and in procedure 2 after the erosive attack. A control group receiving no prophylactic treatment was included. Surface nanohardness (SNH) of enamel specimens was measured after pellicle formation and after completion of daily cyclic treatment.


RESULTS
SNH significantly decreased at the end of the experiment for all groups (p<0.05). In both procedures, there was no statistically significant difference between the control group and those treated with paste slurries (p>0.05). In addition, the changes in SNH (ΔSNH=SNHbaseline-SNHfinal) did not show statistically significant difference between both procedures (p>0.05).


CONCLUSIONS
Tooth erosion cannot be prevented or repaired by these novel agents, regardless of fluoride content.
Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Freiburgstrasse 7, CH-3010 Bern, Switzerland.
X
X
Wang
B
B
Megert
E
E
Hellwig
K W
KW
Neuhaus
A
A
Lussi
D001628:Beverages / Q000009:adverse effects; D002364:Caseins / Q000008:administration & dosage / Q000627:therapeutic use; D002957:Citrus; D003743:Dental Enamel / Q000187:drug effects / Q000648:ultrastructure; D044622:Dental Pellicle / Q000187:drug effects / Q000648:ultrastructure; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D005638:Fruit; D005898:Glass; D006244:Hardness; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053210:Pharmaceutical Preparations, Dental / Q000008:administration & dosage / Q000627:therapeutic use*; D012464:Saliva, Artificial; D013696:Temperature; D013997:Time Factors; D014077:Tooth Erosion / Q000473:pathology / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods*
D002364:Caseins; C510984:NovaMin; D053210:Pharmaceutical Preparations, Dental; D012464:Saliva, Artificial; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D005459:Fluorides