Cranial nerve palsy in multiple myeloma and solitary plasmacytoma.
Cranial nerve involvement in multiple myeloma and solitary plasmacytoma is rare. We report on two patients who developed cranial nerve palsy due to skull base plasmacytoma. Patient 1, a 55-year old man with multiple myeloma, developed right sixth cranial nerve palsy during a phase of chemotherapy. He had an intracranial plasmacytoma in the clival region and was treated with 30 Gy whole brain radiotherapy. Patient 2, a 40-year old man, presented with right third cranial nerve palsy and was detected to have a solitary skull base plasmacytoma. He was treated with radiotherapy followed by thalidomide plus dexamethasone.
Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. rajkashyapmd@yahoo.co.in
Rajesh
R
Kashyap
Raj
R
Kumar
Shaleen
S
Kumar
D020434:Abducens Nerve Diseases / Q000209:etiology*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D015840:Oculomotor Nerve Diseases / Q000209:etiology*; D010954:Plasmacytoma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D011878:Radiotherapy; D019292:Skull Base Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D013792:Thalidomide / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D013792:Thalidomide; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin