Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5.
Eighty-six varicella-zoster virus (VZV) strains of clades 1, 3 and 5, isolated from varicella and zoster patients in Germany, were analyzed by sequencing the glycoprotein E gene. Four novel non-synonymous and 10 novel synonymous mutations were detected. Of these, two synonymous (C513T, C885T) and two non-synonymous mutations (T485G, C524T) were located within the coding regions of e1 and c1. The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5.
Reference Laboratory for HSV and VZV, Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans-Knoell-Strasse 2, 07745 Jena, Germany. Andreas.Sauerbrei@med.uni-jena.de
Andreas
A
Sauerbrei
Nadine
N
Wiesener
Roland
R
Zell
Peter
P
Wutzler
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D002644:Chickenpox / Q000821:virology; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D005858:Germany; D006023:Glycoproteins / Q000235:genetics*; D006562:Herpes Zoster / Q000821:virology; D014645:Herpesvirus 3, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D017421:Sequence Analysis; D015678:Viral Structural Proteins / Q000235:genetics*; D055815:Young Adult
D006023:Glycoproteins; D015678:Viral Structural Proteins