Metabolic regulation of stem cell behavior and implications for aging.
Caloric intake influences metabolic homeostasis, somatic maintenance, tissue regeneration, and longevity in metazoans. Recent studies indicate that nutrient-dependent changes in stem cell populations play an important role in these effects. Here, we review the emerging picture of how nutrient-sensing pathways affect stem cell behavior, providing a mechanism to influence life span.
Department of Biology, University of Rochester, River Campus Box 270211, Rochester, NY 14627, USA. henri_jasper@urmc.rochester.edu
Heinrich
H
Jasper
D Leanne
DL
Jones
D000818:Animals; D005854:Germ Cells / Q000166:cytology*; D006801:Humans; D008136:Longevity / Q000502:physiology*; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D009752:Nutritional Status / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology*