A new neuroprotective bakkenolide from the rhizome of Peatasites tatewakianus.
Constituents of the fruits of Peatasites tatewakianus were investigated. A new compound, namely bakkenolide-VI (1), was isolated. The structures was elucidated on the basis of 1D, 2D NMR, TOF-MS and ESI-MS techniques, and physicochemical properties. The neuroprotective activity of the new compound was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults.
Branch Hospital in Fengxian of Shanghai No 6 People’s Hospital, Shanghai, PR China.
Zhen-Liang
ZL
Sun
Gang-Long
GL
Gao
Jian-Ying
JY
Luo
Xue-Li
XL
Zhang
Ming
M
Zhang
Jing
J
Feng
D018929:Cell Culture Techniques; D005638:Fruit; D005947:Glucose / Q000172:deficiency; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D036901:Petasites / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis / Q000379:methods
D018696:Neuroprotective Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; C560691:bakkenolide VI; D005947:Glucose; D010100:Oxygen