Apolipoprotein B is related to arterial pulse wave velocity in young adults: the Cardiovascular Risk in Young Finns Study.
OBJECTIVE
Limited data are available regarding the relationship of apolipoproteins B (ApoB) and A-1 (ApoA-1) with arterial stiffness. We conducted the present study to determine whether adulthood ApoB and ApoA-1 are related to arterial pulse wave velocity (PWV). Moreover, we examined whether ApoB and ApoA-1 measured in young adulthood are predictive of PWV assessed 6 years later.


METHODS
The study population consisted of 1618 apparently healthy Finnish young adults (aged 30-45 years, 44.9% males) whose apolipoproteins, other cardiovascular risk factors and PWV were measured in 2007. In a sub-sample population, apolipoproteins and other cardiovascular risk factors had also been measured in 2001 (n=1264). PWV measurements were performed using a whole-body impedance cardiography device.


RESULTS
ApoB (p<0.001) and the ApoB/ApoA-1 ratio (p<0.001) were directly associated with PWV. ApoB and the ApoB/ApoA-1 ratio measured in young adulthood were also predictive of PWV measured 6 later (p<0.001 for both). These relations remained significant (p<0.006) in models adjusted for non-lipid risk factors. The areas under the receiver-operating characteristic (ROC) curves (AUC) were similar for ApoB and non-HDL cholesterol (2001: p for AUC comparison=0.15; 2007: p for AUC comparison=0.07) in detecting subjects with increased PWV (PWV≥90th percentile).


CONCLUSIONS
The present study suggests that elevation of ApoB or non-HDL cholesterol is associated with increased arterial stiffness in young adults.
Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland. teemu.koivistoinen@uta.fi
Teemu
T
Koivistoinen
Nina
N
Hutri-Kähönen
Markus
M
Juonala
Tiit
T
Kööbi
Heikki
H
Aatola
Terho
T
Lehtimäki
Jorma S A
JS
Viikari
Olli T
OT
Raitakari
Mika
M
Kähönen
D000328:Adult; D016632:Apolipoprotein A-I / Q000378:metabolism; D001055:Apolipoproteins B / Q000378:metabolism*; D001158:Arteries / Q000473:pathology*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood; D008076:Cholesterol, HDL / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D005387:Finland; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012307:Risk Factors; D055815:Young Adult
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL