Effects of whey protein concentrate (WPC) on the distributions of lymphocyte subpopulations in rats with excessive alcohol intake.
To investigate the effects of whey protein concentrate (WPC) on antioxidant statuses and the lymphocyte subpopulations in the rats with alcohol intake, the antioxidant statuses in the peripheral blood (PB) and the lymphocyte subpopulations in the PB, spleen, and bone marrow (BM) of the rats fed with WPC (0.334 g/kg) and alcohol (6 g/kg) for 3 months were analyzed. Results showed that the effects of WPC on the glutathione peroxidase and glutathione in the PB, the T and B cells in the spleen, and the B cells in the BM were more apparent in the rats with alcohol intake; however, they are not apparent in the controls. Taken together, our results indicated that the immunity of rats might be enhanced by the increased antioxidant ability after WPC supplementation and the effects of WPC on the lymphocyte subpopulations were mainly in the spleen and BM and not in the PB.
Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Number 386, Ta-chung 1st Road, Kaohsiung 81346, Taiwan.
Yang-Ming
YM
Tseng
Shih-Meng
SM
Tsai
Wen-Shan
WS
Lin
Zih-Ru
ZR
Huang
Chun-Chin
CC
Lin
Wei-Hao
WH
Yeh
Yi-Ru
YR
Wu
Li-Yu
LY
Tsai
D000428:Alcohol Drinking / Q000009:adverse effects / Q000188:drug therapy* / Q000276:immunology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D005978:Glutathione / Q000276:immunology; D005979:Glutathione Peroxidase / Q000276:immunology; D006801:Humans; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D008297:Male; D008894:Milk Proteins / Q000008:administration & dosage*; D023421:Models, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D000067816:Whey Proteins
D000975:Antioxidants; D008894:Milk Proteins; D000067816:Whey Proteins; D005979:Glutathione Peroxidase; D005978:Glutathione