Complementary diffusion tensor imaging study of the corpus callosum in patients with first-episode and chronic schizophrenia.
BACKGROUND
Abnormalities in the corpus callosum have long been implicated in schizophrenia. Previous diffusion tensor imaging (DTI) studies in patients with different durations of schizophrenia yielded inconsistent results. By comparing patients with different durations of schizophrenia, we investigated if white matter abnormalities of the corpus callosum emerge at an early stage in the illness or result from pathological progression.


METHODS
We recruited patients with first-episode schizophrenia, patients with chronic schizophrenia and age-, sex- and handedness-matched healthy controls. We used 2 DTI techniques (voxel-based and fibre-tracking DTI) to investigate differences in corpus callosum integrity among the 3 groups.


RESULTS
With both DTI techniques, significantly decreased fractional anisotropy values were identified in the genu of corpus callosum in patients with chronic schizophrenia, but not first-episode schizophrenia, compared with healthy controls.


CONCLUSIONS
This study was cross-sectional, and the sample size was relatively small.


CONCLUSIONS
Abnormalities in the genu of the corpus callosum might be a progressive process in schizophrenia, perhaps related to disease severity and prognosis.
The Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha, P R China.
Xiangjuan
X
Kong
Xuan
X
Ouyang
Haojuan
H
Tao
Haihong
H
Liu
Li
L
Li
Jingping
J
Zhao
Zhimin
Z
Xue
Fei
F
Wang
Shaoai
S
Jiang
Baoci
B
Shan
Zhening
Z
Liu
D000328:Adult; D000704:Analysis of Variance; D016880:Anisotropy; D001931:Brain Mapping; D003337:Corpus Callosum / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D018579:Patient Selection; D012559:Schizophrenia / Q000473:pathology*