Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis.
OBJECTIVE
This study aims to test for possible associations between the gene coding for the 5-HT2C receptor and antipsychotic-induced weight gain.


METHODS
Four HTR2C polymorphisms (rs498207, C-759T, G-697C and Ser23Cys) were investigated in our sample of 205 chronic schizophrenia patients.


RESULTS
Significant over-representation of the C-G-Cys23 haplotype in patients with weight gain (OR: 1.93; 95% CI: 1.04-3.56; p = 0.0015) was found. Similarly, haplotype analyses of percentage weight change were also significant (p = 0.029) for the C-G-Cys23 haplotype associated with the highest average percent weight gain. Observations in the polymorphisms are consistent with previous studies. An updated meta-analysis of nine previous studies plus our current sample suggest that the -759C allele is associated with antipsychotic-induced weight gain.


CONCLUSIONS
Additional studies, including the resequencing of the region surrounding the HTR2C promoter, and functional studies of the promoter polymorphisms, may elucidate the mechanism underlying this genetic association.
Neurogenetics Section, Centre for Addiction & Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Michelle N
MN
Sicard
Clement C
CC
Zai
Arun K
AK
Tiwari
Renan P
RP
Souza
Herbert Y
HY
Meltzer
Jeffrey A
JA
Lieberman
James L
JL
Kennedy
Daniel J
DJ
Müller
D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics
D014150:Antipsychotic Agents; D044405:Receptor, Serotonin, 5-HT2C