[Dermatopharmacokinetic studies of liangfu cream in mice skin].
OBJECTIVE
To study the relationship between deposition content and time of the active ingredients in rat skin, and investigate the dermatopharmacokinetics of Liangfu Cream.


METHODS
The contents of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in rat skin were determined by HPLC. The dermatopharmacokinetics parameters were calculated by DAS software.


RESULTS
The dermatopharmacokinetics of paeonol and glycyrrhetinic acid were two compartment model, while that of dictamnine and fraxinellone were one compartment model: T(1/2Ka) of four active ingredients were 0.307, 0.112, 0.146, 0.216 h, respectively; T(lag) of them were 0.006, 0.123, 0.136, 0.109 h, respectively; all the Tmax of them was 0.5 h; the Cmax, were 40.163, 1.607, 6.725, 100.553 microg x cm(-3), respectively; the t(1/2beta), were 14.719, 1.262, 0.838, 234.807 h, respectively; the AUC(0-infinity), were 16.987, 2.713, 9.345, 697.000 microg x cm(-3) x h(-1), respectively; and the MRT(0-infinity) were 3.662, 1.67, 1.585, 10.897, respectively.


CONCLUSIONS
The skin pharmacokinetics characteristic of four ingredients in Liangfu cream is lined with the cataplasm long time.
Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Nanchang 330004, China.
Sen
S
Wang
Shuiping
S
Ou
Yongmei
Y
Guan
Dezhi
D
Wu
Lihua
L
Chen
Weifeng
W
Zhu
D000098:Acetophenones / Q000008:administration & dosage / Q000493:pharmacokinetics; D000279:Administration, Cutaneous; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000493:pharmacokinetics; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006034:Glycyrrhetinic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics; D012867:Skin / Q000187:drug effects*
D000098:Acetophenones; D001572:Benzofurans; D004365:Drugs, Chinese Herbal; D011804:Quinolines; C075391:fraxinellone; C013638:paeonol; C026398:dictamnine; D006034:Glycyrrhetinic Acid