Melatonin modifies the rhythm of protein synthesis.
Melatonin (5 nM) added to medium with primary hepatocyte cultures shifted the phase of circahoralian rhythm of protein synthesis and hence, can be a factor synchronizing fluctuations in protein synthesis and rhythm organizer in the hepatocyte population. Blockade of melatonin receptors with luzindole (20 nM) arrested rhythm organization of protein synthesis by melatonin. Prospects of studying biochemical mechanisms of protein synthesis rhythm organization with other drugs (calcium agonists, similarly to melatonin) are discussed.
N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. brodsky.idb@bk.ru
V Y
VY
Brodsky
N D
ND
Dubovaya
T K
TK
Zvezdina
V I
VI
Fateeva
L A
LA
Mal'chenko
D000818:Animals; D002478:Cells, Cultured; D022781:Hepatocytes / Q000378:metabolism*; D008550:Melatonin / Q000494:pharmacology*; D010507:Periodicity; D014176:Protein Biosynthesis / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D044094:Receptors, Melatonin / Q000037:antagonists & inhibitors; D014363:Tryptamines / Q000494:pharmacology
D044094:Receptors, Melatonin; D014363:Tryptamines; C057154:luzindole; D008550:Melatonin