Early-life stress and cognitive outcome.
BACKGROUND
Early-life stress is associated with later neuropsychiatric illness. While the association between early-life stress and brain development is well recognized, relatively few studies have examined the association between exposure to early-life stress and cognitive outcome.


OBJECTIVE
The objective of this paper is to examine the association between early-life stress and cognitive outcome in animal models and humans.


METHODS
In this article, we review alterations in cognitive function associated with early-life stress in animals and then discuss the association of early-life stress and cognitive function in humans.


RESULTS
Findings suggest that early-life stress is associated with abnormal cognitive function in animals and humans. Furthermore, cognitive deficits associated with exposure to early-life stress in humans may persist into at least early adulthood, although animal models of enriched environments and studies of children adopted from institutionalized care into foster families suggest that certain social factors may at least partially reverse cognitive deficits following exposure to early-life stress.


CONCLUSIONS
Exposure to stress in early life may be associated with later deficits in cognitive function.
Department of Psychology, Brigham Young University, Provo, UT 84602, USA. dawson_hedges@byu.edu
Dawson W
DW
Hedges
Fu Lye
FL
Woon
D000818:Animals; D001921:Brain / Q000254:growth & development; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D008016:Life Change Events; D013315:Stress, Psychological / Q000150:complications*; D013997:Time Factors