Neurobehavioral evidence for the "Near-Miss" effect in pathological gamblers.
The purpose of this translational study was twofold: (1) to contrast behavioral and brain activity between pathological and nonpathological gamblers, and (2) to examine differences as a function of the outcome of the spin of a slot machine, focusing predominately on the "Near-Miss"--when two reels stop on the same symbol, and that symbol is just above or below the payoff line on the third reel. Twenty-two participants (11 nonpathological; 11 pathological) completed the study by rating the closeness of various outcomes of slot machine displays (wins, losses, and near-misses) to a win. No behavioral differences were observed between groups of participants, however, differences in brain activity were found in the left midbrain, near the substantia nigra and ventral tegmental area (SN / VTA). Near-miss outcomes uniquely activated brain regions associated with wins for the pathological gamblers and regions associated with losses for the nonpathological gamblers. Thus, near-miss outcomes on slot machines may contain both functional and neurological properties of wins for pathological gamblers. Such a translational approach to the study of gambling behavior may be considered an example that gives life to B. F. Skinner's conceptualization of the physiologist of the future.
Department of Psychology, Southern Illinois University, Carbondale, IL 62901, USA. rhabib@siu.edu
Reza
R
Habib
Mark R
MR
Dixon
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005715:Gambling / Q000503:physiopathology* / Q000523:psychology*; D005717:Games, Experimental; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000503:physiopathology*; D009483:Neuropsychological Tests; D012201:Reward; D013378:Substantia Nigra / Q000503:physiopathology; D017557:Ventral Tegmental Area / Q000503:physiopathology