Antioxidant and antifungal properties of benzimidazole derivatives.
Antioxidant and radical scavenging properties of a series of 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives were examined. Free radical scavenging properties of compounds 11-30 and 33 were evaluated for the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide anion radical. In addition the inhibitory effects on the NADPH-dependent lipid peroxidation levels were determined by measuring the formation of 2-thiobarbituric acid reactive substances (TBARS) using rat liver microsomes. Compound 33 which has a p-fluorobenzyl substitutent at position 1 exhibited the strongest inhibition (83%) of lipid peroxidation at a concentration of 10(-3) M, while the nonsubstituted analogue 13 caused 57% inhibition. This result is fairly consistent with the antimicrobial activity results against both Staphylococcus aureus and Candida albicans.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara, Turkey. kus@pharmacy.ankara.edu.tr
Canan
C
Kuş
Fatma
F
Sözüdönmez
Benay
B
Can-Eke
Tülay
T
Coban
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009249:NADP / Q000378:metabolism; D010851:Picrates / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013481:Superoxides / Q000378:metabolism / Q000494:pharmacology*
D000935:Antifungal Agents; D000975:Antioxidants; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D013481:Superoxides; D002084:Butylated Hydroxytoluene; D009249:NADP; C004931:1,1-diphenyl-2-picrylhydrazyl