Copper catalysis in the construction of indole and benzo[b]furan rings.
This perspective reports on some of the main copper-catalyzed routes to the construction of the pyrrole and furan rings incorporated into the indole and benzo[b]furan systems, respectively. The first part illustrates the synthesis of indoles through cyclizations of 2-alkynylanilid(n)es, preformed or generated in situ, and cyclizations via intramolecular N-arylation, N-vinylation, and C-C bond forming reactions. The second part illustrates the synthesis of benzo[b]furans through cyclizations of preformed 2-alkynylphenols, domino synthesis of 2-alkynylphenols/cyclization processes, and cyclizations via intramolecular O-arylation reactions.
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185, Rome, Italy. sandro.cacchi@uniroma1.it
Sandro
S
Cacchi
Giancarlo
G
Fabrizi
Antonella
A
Goggiamani
D001572:Benzofurans / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008024:Ligands
D001572:Benzofurans; D007211:Indoles; D008024:Ligands; D003300:Copper; C030374:indole; C105430:benzofuran