Cavitation-enhanced delivery of macromolecules into an obstructed vessel.
Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring.
Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford OX1 3PJ, United Kingdom. bassel.rifai@eng.ox.ac.uk
Bassel
B
Rifai
Costas D
CD
Arvanitis
Miriam
M
Bazan-Peregrino
Constantin-C
CC
Coussios
D000162:Acoustics; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D046911:Macromolecular Substances / Q000493:pharmacokinetics*; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy*; D059016:Tumor Microenvironment; D014464:Ultrasonic Therapy / Q000379:methods*; D014463:Ultrasonography
D000970:Antineoplastic Agents; D046911:Macromolecular Substances