Monoclonal antibodies in the treatment of hematologic malignancy.
Methods to generate monoclonal antibodies to antigens of neoplastic cells have revolutionized our understanding of cancer cell growth and differentiation, diagnosis, and treatment. Monoclonal antibodies derived by immunizing animals (mostly mice) with mammalian cells or molecules have been critical reagents for the discovery and characterization of many key molecules involved in the behavior of neoplastic cells. Now, over 30 years later, monoclonal antibodies are widely used in the differential diagnosis of cancer and are key elements in the treatment of many forms of cancer. This review will focus on the roles that monoclonal antibodies play in the treatment of hematological malignancies. In particular, we will focus on acute myeloid leukemia and mature B-cell neoplasms.
University of California San Diego Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92093-0960, USA. tball@ucsd.edu
Edward D
ED
Ball
H Elizabeth
HE
Broome
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D015448:Leukemia, B-Cell; D015470:Leukemia, Myeloid, Acute; D016393:Lymphoma, B-Cell
D000911:Antibodies, Monoclonal