A conceptually new type of bio-hybrid scaffold for bone regeneration.
Magnetic bio-hybrid porous scaffolds have been synthesized, nucleating nano-apatite in situ on self-assembling collagen, in the presence of magnetite nano-particles. The magnetic phase acted as a sort of cross-linking agent for the collagen, inducing a chemico-physical-mechanical stabilization of the material and allowing us to control the porosity network of the scaffold. Gradients of bio-mineralization and magnetization were also developed for osteochondral application. The good potentiality of the material as a biomedical device, able to offer assistance to bone regeneration through scaffold reloading with specific factors guided by an external magnetic field, has been preliminarily investigated. Up to now the proof of this concept has been realized through in vitro assessments.
ISTEC-CNR, Institute of Science and Technology for Ceramics-National Research Council, Faenza (RA), Italy.
A
A
Tampieri
E
E
Landi
F
F
Valentini
M
M
Sandri
T
T
D'Alessandro
V
V
Dediu
M
M
Marcacci
D001854:Bone Marrow Cells / Q000166:cytology; D001861:Bone Regeneration; D002130:Calcium Phosphates; D002470:Cell Survival; D055598:Chemical Phenomena; D024042:Collagen Type I / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008854:Microscopy, Electron; D053761:Nanocomposites / Q000737:chemistry*; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013234:Stem Cells / Q000166:cytology; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
D002130:Calcium Phosphates; D024042:Collagen Type I; D058185:Magnetite Nanoparticles; D017886:Durapatite; C020243:calcium phosphate