The role of HLA-G in immunity and hematopoiesis.
The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.
CEA, I2BM, Service de Recherches en Hemato-Immunologie, 75475 Paris, France. Edgardo.Carosella@cea.fr
Edgardo D
ED
Carosella
Silvia
S
Gregori
Nathalie
N
Rouas-Freiss
Joel
J
LeMaoult
Catherine
C
Menier
Benoit
B
Favier
D000818:Animals; D005786:Gene Expression Regulation; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D059951:HLA-G Antigens; D006410:Hematopoiesis; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007109:Immunity; D054992:Immunological Synapses / Q000276:immunology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I