Drug-induced sensorineural deafness caused by antithyroid drugs: a rare side effect.
Acute ototoxicity is a rare but important complication of antithyroid drugs. Although previous cases have been reported in the medical literature, these cases occurred in younger patients with serological evidence of lupus-like syndrome with positive antidouble-stranded deoxyribonucleic acid and antineutrophil cytoplasmic antibodies. We describe the case of a 68-year-old Caucasian male who developed deafness and tinnitus one week after being prescribed carbimazole. The management options include stopping the culprit drug, treatment with immunosuppressive drugs and referring the patient for urgent thyroidectomy. Healthcare professionals who prescribe antithyroid drugs should be aware of this rare but potentially serious complication, so that early drug withdrawal and referral for surgery can be considered.
Diabetes and Endocrinology, Princess Royal Hospital, Telford, UK. umar_yousaf@hotmail.com
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Raja
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Kumar
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Possamai
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Warner
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Barton
D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects*; D002231:Carbimazole / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D014012:Tinnitus / Q000139:chemically induced* / Q000175:diagnosis
D013956:Antithyroid Agents; D002231:Carbimazole