The effect of rotavirus immunization on rotavirus gastroenteritis hospitalization rates in military dependents.
We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6-65.8, P<0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7-91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.
Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences (USUHS), 4301 Jones Bridge Rd, Bethesda, MD 20814, USA. meberly@usuhs.mil
Matthew D
MD
Eberly
Greg H
GH
Gorman
Matilda B
MB
Eide
Cara H
CH
Olsen
Michael
M
Rajnik
D002675:Child, Preschool; D005192:Family Health; D005759:Gastroenteritis / Q000453:epidemiology / Q000517:prevention & control*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007114:Immunization / Q000379:methods; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008889:Military Personnel; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014481:United States / Q000453:epidemiology
D022243:Rotavirus Vaccines