Studies on the anti-inflammatory properties of Plantago erosa leaf extract in rodents.
BACKGROUND
Leaves of Plantago erosa ex Roxb are used traditionally in Northeast India in different illnesses which include wounds, cuts, bruises, insect bites, poison-ivy rashes, minor sores and snakebite, etc.


OBJECTIVE
Plantago erosa is one of the commonly used medicinal plants in various inflammatory conditions in this region; however, due to paucity of scientific literature on its anti-inflammatory property, the present study was aimed at evaluating its anti-inflammatory activity in the leaves using in vivo models of inflammation.


METHODS
Different models like carageenan induced paw edema in rat and mice, formalin induced paw licking in rats and cotton pellet induced granuloma in rats were used for studying the anti-inflammatory activity in methanol extract of Plantago erosa (PEME) leaves.


RESULTS
The PEME at the oral doses from 300 to 600 mg/kg showed anti-inflammatory activity in various models. The extract (PEME) reduced carageenan induced paw edema in rat and mice, inhibited the formation of granulomatous tissue in cotton pellet induced granuloma after treatment and also decreased the reaction time in both early and late phases in formalin induced paw licking in rats.


CONCLUSIONS
The study evidently confirmed anti-inflammatory activity of PEME and thus supported the traditional claim. The anti-inflammatory activity could be attributed to the phytoconstituent (flavonoids, alkaloids and steroid) present in the methanol extract of the plant.
Department of Pharmacology & Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781022, Assam, India. chanacin@gmail.com
Chandana Choudhury
CC
Barua
Saumen Kanti
SK
Pal
Jayanti Datta
JD
Roy
Bhaben
B
Buragohain
Archana
A
Talukdar
Acheenta Gohain
AG
Barua
Prabodh
P
Borah
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry*; D010943:Plantago / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents