The Notch signaling pathway: molecular basis of cell context dependency.
Notch receptor signaling controls cell-fate specification, self-renewal, differentiation, proliferation and apoptosis throughout development and regeneration in all animal species studied to date. Its dysfunction causes several developmental defects and diseases in the adult. A key feature of Notch signaling is its remarkable cell-context dependency. In this review, we summarize the influences of the cellular context that regulate Notch activity and propose a model how the interplay between the cell-intrinsically established chromatin state and the cell-extrinsic signals that modify chromatin may select for Notch target accessibility and activation in different cellular contexts.
Department of Biochemistry, Medical Faculty, Christian-Albrechts-University Kiel, Olshausenstr. 40, 24098 Kiel, Germany.
Ralf
R
Schwanbeck
Simone
S
Martini
Kristina
K
Bernoth
Ursula
U
Just
D017209:Apoptosis / Q000502:physiology; D006801:Humans; D051880:Receptors, Notch / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
D051880:Receptors, Notch