CDD: a Conserved Domain Database for the functional annotation of proteins.
NCBI's Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints. CDD includes manually curated domain models that make use of protein 3D structure to refine domain models and provide insights into sequence/structure/function relationships. Manually curated models are organized hierarchically if they describe domain families that are clearly related by common descent. As CDD also imports domain family models from a variety of external sources, it is a partially redundant collection. To simplify protein annotation, redundant models and models describing homologous families are clustered into superfamilies. By default, domain footprints are annotated with the corresponding superfamily designation, on top of which specific annotation may indicate high-confidence assignment of family membership. Pre-computed domain annotation is available for proteins in the Entrez/Protein dataset, and a novel interface, Batch CD-Search, allows the computation and download of annotation for large sets of protein queries. CDD can be accessed via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA. bauer@ncbi.nlm.nih.gov
Aron
A
Marchler-Bauer
Shennan
S
Lu
John B
JB
Anderson
Farideh
F
Chitsaz
Myra K
MK
Derbyshire
Carol
C
DeWeese-Scott
Jessica H
JH
Fong
Lewis Y
LY
Geer
Renata C
RC
Geer
Noreen R
NR
Gonzales
Marc
M
Gwadz
David I
DI
Hurwitz
John D
JD
Jackson
Zhaoxi
Z
Ke
Christopher J
CJ
Lanczycki
Fu
F
Lu
Gabriele H
GH
Marchler
Mikhail
M
Mullokandov
Marina V
MV
Omelchenko
Cynthia L
CL
Robertson
James S
JS
Song
Narmada
N
Thanki
Roxanne A
RA
Yamashita
Dachuan
D
Zhang
Naigong
N
Zhang
Chanjuan
C
Zheng
Stephen H
SH
Bryant
D000595:Amino Acid Sequence; D017124:Conserved Sequence; D030562:Databases, Protein; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000145:classification; D020539:Sequence Analysis, Protein
D011506:Proteins