What makes plaques vulnerable in CKD?: a fresh look at metalloproteinases.
Coll et al. show that across the spectrum of chronic kidney disease (CKD), atherosclerosis severity is correlated with metalloproteinase-10 (MMP-10) levels. This suggests that the reduced fibrous content in atherosclerotic plaques may result partly from high MMP-10. Future studies should look at the association of MMPs (and their inhibitors) with the inflammatory component of atherosclerosis, and with stable and unstable atherosclerotic lesions.
Department of Nephrology, Hypertension and Renal Transplantation, CNR-IBIM Clinical Epidemiology of Renal Diseases and Hypertension, Ospedali Riuniti, Reggio Calabria, Italy. carmine.zoccali@tin.it
Carmine
C
Zoccali
Sidy
S
Seck
D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism*; D053506:Matrix Metalloproteinase 10 / Q000378:metabolism*; D058226:Plaque, Atherosclerotic / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D012307:Risk Factors; D012720:Severity of Illness Index
D015415:Biomarkers; D053506:Matrix Metalloproteinase 10