Histone deacetylase inhibitors in Hodgkin lymphoma.
Although Hodgkin lymphoma (HL) is considered one of the most curable human cancers, the treatment of patients with relapsed and refractory disease, especially those who relapse after autologous stem cell transplantation, remains challenging. Furthermore, because of the young age of these patients, the impact of early mortality on the number of years lost from productive life is remarkable. Patients with relapsed HL post stem cell transplantation currently have no curative therapy, and are in need for new drugs and novel treatment strategies. While no new drugs have been approved for the treatment of patients with HL in more than three decades, several new agents are demonstrating promising results in early clinical trials. This review will focus on the emerging role of histone deacetylase inhibitors in patients with relapsed HL.
Department of Lymphoma/Myeloma, 1515 Holcombe Boulevard, Box # 429, Houston, TX 77030, USA.
Daniela
D
Buglio
Anas
A
Younes
D002986:Clinical Trials as Topic; D044127:Epigenesis, Genetic / Q000187:drug effects; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006655:Histone Deacetylases / Q000378:metabolism; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000201:enzymology*; D006801:Humans; D012008:Recurrence
D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases