Two pairs of enantiomeric neolignans from Lobelia chinensis.
A pair of new enantiomeric neolignans, ethyl 3-[(2R,3S)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl] propanoate (+) (1) and ethyl 3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl] propanoate (-) (1), together with a pair of known enantiomeric neolignans (+) (2) and (-) (2), as well as five known lignans (3-7) were isolated from the ethanol extract of Lobelia chinensis. Their structures were elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS and CD spectra.
Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, PR China.
Jian-Xin
JX
Chen
Shen-Hui
SH
Huang
Lei
L
Wang
Wei-Li
WL
Han
Ying
Y
Wang
Dong-Mei
DM
Zhang
Wen-Cai
WC
Ye
D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D029746:Lobelia / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D017705:Lignans