Pegfilgrastim overdose: case report and review of the literature.
Single-dose pegfilgrastim is commonly used for the prophylaxis of neutropenia in patients receiving myelotoxic chemotherapy. We report a case of a 69-year-old man who was treated with chemotherapy for small-cell lung cancer and mistakenly self-administered a 36 mg overdose of pegfilgrastim, a sixfold increase over the scheduled dose.
Division of Oncology, Rambam Health Care Campus, POB 9602, 31096 Haifa, Israel.
Orit
O
Kaidar-Person
Mor
M
Moskovitz
Tomer
T
Charas
Wasim
W
Alsharbati
Nissim
N
Haim
D000368:Aged; D062787:Drug Overdose; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008508:Medication Errors / Q000009:adverse effects*; D011092:Polyethylene Glycols; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D012648:Self Care / Q000009:adverse effects* / Q000379:methods
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim