Vapour-phase gold-surface-mediated coupling of aldehydes with methanol.
Selective coupling of oxygenates is critical to many synthetic processes, including those necessary for the development of alternative fuels. We report a general process for selective coupling of aldehydes and methanol as a route to ester synthesis. All steps are mediated by oxygen-covered metallic gold nanoparticles on Au(111). Remarkably, cross-coupling of methanol with formaldehyde, acetaldehyde, benzaldehyde and benzeneacetaldehyde to methyl esters is promoted by oxygen-covered Au(111) below room temperature with high selectivity. The high selectivity is attributed to the ease of nucleophilic attack of the aldehydes by the methoxy intermediate-formed from methanol on the surface-which yields the methyl esters. The competing combustion occurs via attack of both methanol and the aldehydes by oxygen. The mechanistic model constructed in this study provides insight into factors that control selectivity and clearly elucidates the crucial role of Au nanoparticles as active species in the catalytic oxidation of alcohols, even in solution.
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Bingjun
B
Xu
Xiaoying
X
Liu
Jan
J
Haubrich
Cynthia M
CM
Friend
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D005740:Gases / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D013058:Mass Spectrometry; D053768:Metal Nanoparticles / Q000737:chemistry; D000432:Methanol / Q000737:chemistry*; D010084:Oxidation-Reduction; D013499:Surface Properties; D013696:Temperature
D000447:Aldehydes; D005740:Gases; D006046:Gold; D000432:Methanol