Successful monozygotic twin pregnancy fathered by a male 46,XY true hermaphrodite.
This report presents an unusual case of absolute non-obstructive azoospermia revealed to be a male 46,XY true hermaphrodite who was successfully treated to father healthy monozygotic twins. A 27-year-old infertile male with non-obstructive azoospermia previously underwent an unsuccessful testicular sperm extraction procedure and refused donor sperm insemination.Revising the patient’s old records revealed that he was born with ambiguous genitalia. He had a 46,XY karyotype and was raised as a male. During childhood he underwent ambiguous genitalia reconstruction, right orchiopexy and left salpingo-oophorectomy that revealed a gonadoblastoma. A new treatment was employed performing testicular fine needle aspiration leading successfully to a monozygotic twin pregnancy. As far as is known, this is the first reported case of healthy twins fathered by a male 46,XY true hermaphrodite.
Reproductive Medicine Unit, Department of Obstetrics and Gynecology, Poriya Medical Center, Tiberias, Israel. jsy@netvision.net.il
Johnny S
JS
Younis
Orit
O
Radin
Hedviga
H
Kerner
Moshe
M
Ben-Ami
D000328:Adult; D053713:Azoospermia / Q000209:etiology* / Q000628:therapy*; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D008297:Male; D050090:Ovotesticular Disorders of Sex Development / Q000175:diagnosis; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D053625:Sperm Retrieval; D013737:Testis; D014430:Twins, Monozygotic