anticonvulsant and toxicity evaluation of newer 4H-benzo[1,4]oxazin-3-ones: The effect of two hydrogen bonding domains.
A series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides (6a-r) was synthesized using 2-amino-5-nitrophenol as a starting material. All the synthesized compounds possessed two hydrogen-bonding domains and their effect on the activity was studied thereof. The anticonvulsant activity was assessed by the maximal electroshock test (MES), subcutaneous pentylenetetrazole test (scPTZ) and intraperitoneal thiosemicarbazide test (ipTSC). Compounds (6b, 6h, 6i, and 6p) were found to be the most potent of the series as they showed 83-100% protection in the MES test. They also displayed considerable activity in the chemically induced seizure tests. Most of the tested compounds were devoid of the neurotoxic and hepatotoxic effects.
Department of Pharmaceutical Chemistry, Hamdard University, New Delhi, India. nadeems_03@yahoo.co.in
Nadeem
N
Siddiqui
Ruhi
R
Ali
M Faiz
MF
Arshad
Waquar
W
Ahsan
Sharique
S
Ahmed
M Shamsher
MS
Alam
D000577:Amides; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006860:Hydrogen Bonding; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D012640:Seizures / Q000188:drug therapy
D000577:Amides; D000927:Anticonvulsants; D010078:Oxazines