The effects of simvastatin on angiogenesis: studied by an original model of atherosclerosis and acute myocardial infarction in rabbit.
Statins have shown pleiotropic effects, many of them independent of their impact on lipids. Angiogenesis can be beneficial in the acute myocardial infarction to improve circulation. However, it also can be harmful due to worsening of atherosclerosis. Here, we established a new minimal invasive rabbit model to study ischemic myocardium and atherosclerosis together to mimic clinical scenario. We demonstrated that simvastatin has the effect of pro-angiogenesis and further improve cardiac function in ischemic myocardium, as well as the effect of anti-angiogenesis to improve atherosclerosis in aorta vessels.
Department of Cardiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, People's Republic of China.
Wei
W
Shen
Hai-Ming
HM
Shi
Wei-Hu
WH
Fan
Xin-Ping
XP
Luo
Bo
B
Jin
Yong
Y
Li
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017023:Coronary Angiography; D004195:Disease Models, Animal; D006334:Heart Function Tests / Q000187:drug effects; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D007150:Immunohistochemistry; D008055:Lipids / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011817:Rabbits; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008055:Lipids; D042461:Vascular Endothelial Growth Factor A; D019821:Simvastatin; D040301:Vascular Endothelial Growth Factor Receptor-2