Allogeneic haematopoietic stem cell transplantation for myelofibrosis: a report of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).
Allogeneic haematopoietic stem-cell transplantation (HSCT) is the only curative treatment for myelofibrosis. We report an analysis of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) registry including patients with myelofibrosis transplanted between 1997 and 2008. Potential risk factors affecting engraftment, non-relapse mortality (NRM), overall survival (OS) and progression-free survival (PFS) were analysed. One hundred and forty-seven patients, aged 20-68 (median 53) years, diagnosed with primary (53%) or secondary myelofibrosis underwent HSCT; 59% of patients were transplanted from a matched sibling donor. The conditioning regimen was myeloablative in 31% of patients. Ninety percent of the patients engrafted. Factors affecting favourably engraftment were splenectomy before HSCT, human leucocyte antigen (HLA) matched sibling donor, peripheral stem cell use as source of stem cells and absence of pre-transplant thrombocytopenia. Four-year OS, PFS and NRM survival were 39% (95%confidence interval [CI]: 31-50), 32% (95%CI: 24-43) and 39% (95%CI 30-48), respectively. Multivariate analysis indicated that HLA-identical sibling donor, chronic phase disease and splenectomy in men had favourable impact on OS.
Service d'hématologie-greffe, Hôpital Saint-Louis, AP-HP, Paris, France Service d'hématologie, Hôpital du Haut Levêque, Pessac, Université Bordeaux, France. marie.robin@univ-paris-diderot.fr
Marie
M
Robin
Reza
R
Tabrizi
Mohamad
M
Mohty
Sabine
S
Furst
Mauricette
M
Michallet
Jacques-Olivier
JO
Bay
Jean-Yves
JY
Cahn
Eric
E
De Coninck
Nathalie
N
Dhedin
Marc
M
Bernard
Bernard
B
Rio
Agnès
A
Buzyn
Anne
A
Huynh
Karin
K
Bilger
Pierre
P
Bordigoni
Nathalie
N
Contentin
Raphaël
R
Porcher
Gérard
G
Socié
Noel
N
Milpied
D000328:Adult; D000368:Aged; D004812:Epidemiologic Methods; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006648:Histocompatibility; D006801:Humans; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000628:therapy*; D011379:Prognosis; D012008:Recurrence; D013156:Splenectomy; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult