How does PKMζ maintain long-term memory?
Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.
The Robert F. Furchgott Center of Neural and Behavioural Science, Department of Physiology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA. tsacktor@downstate.edu
Todd C
TC
Sacktor
D000818:Animals; D004789:Enzyme Activation / Q000502:physiology; D006801:Humans; D057567:Memory, Long-Term / Q000502:physiology*; D011493:Protein Kinase C / Q000096:biosynthesis / Q000502:physiology*; D013569:Synapses / Q000201:enzymology
D011493:Protein Kinase C; C504730:protein kinase M zeta, rat