Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart disease: a meta-analysis.
Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the association of between the LP-PLA2 gene polymorphism and CHD risk. To assess the relationship between LP-PLA2 gene V279F polymorphism and CHD, a comprehensive Meta-analysis was performed. All the case-control studies evaluating the association of between the LP-PLA2 gene V279F polymorphism and CHD risk were identified. Seven case-control studies involving 3,614 patients with CHD and 4,334 controls were included. The crude odds ratios (ORs) of meta-analysis under the different gene model were not significant. But in the stratified analysis by study size, ethnicity, cases definition, and source of controls under the additive model, the association was evident in ethnicity for Japanese group (OR=1.38, 95%CI=1.22-1.56), cases definition for MI (OR=1.22, 95%CI=1.01-1.49), source of controls for the based-hospital (OR=1.42, 95%CI=1.24-1.59). These data suggested that the V279F polymorphism in LP-PLA2 gene may contribute to CHD development. But there is necessary that more well-designed large studies are required for the validation of this association.
The Centre of Evidence Based Medicine, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, No 1 Huatuo road, Shangjie University Town, Fuzhou, China. zhgh_1969@yahoo.com.cn
Guo-Hua
GH
Zheng
Hai-Ying
HY
Chen
Shang-Quan
SQ
Xiong
Jian-Feng
JF
Chu
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000235:genetics*; D019943:Amino Acid Substitution / Q000235:genetics*; D003327:Coronary Disease / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012044:Regression Analysis; D012307:Risk Factors
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase