[Long-term complications following treatment of testicular cancer and Hodgkin lymphoma].
Patients who were treated in the past with radiotherapy or chemotherapy for testicular cancer or Hodgkin lymphoma are at risk of new malignancies and cardiovascular disease on the long run. Two patient groups who were diagnosed in various hospitals in the Netherlands as having testicular cancer and Hodgkin lymphoma in the period 1965-1995 have survived for a mean period of almost 20 years by now. Both patient groups have higher risks of a new malignancy or cardiovascular disease following radiotherapy and/or chemotherapy than the general population or patients treated without or with less intensive radiotherapy or chemotherapy. As recovery of Hodgkin lymphoma is only achieved by a more intensive treatment approach than the treatment approach for testicular cancer, the risks of a new malignancy or cardiovascular disease are considerably higher among survivors of Hodgkin lymphoma than among survivors of testicular cancer. In both patient groups the long-term risks of new malignancies and cardiovascular disease are still raised in both patient groups up to 25 years after treatment. Because of the relatively high risks of late treatment complications, recommendations for follow-up for survivors of testicular cancer and Hodgkin lymphoma are necessary.
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, Afd. Epidemiologie, Amsterdam, the Netherlands.
A W Sandra
AW
van den Belt-Dusebout
Berthe M P
BM
Aleman
Jourik A
JA
Gietema
Ronald
R
de Wit
Mars B
MB
van 't Veer
P J Elly
PJ
Lugtenburg
A D G Stijn
AD
Krol
Floor E
FE
van Leeuwen
D000970:Antineoplastic Agents / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D017741:Survivors / Q000706:statistics & numerical data; D013736:Testicular Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D013997:Time Factors
D000970:Antineoplastic Agents