Leucocyte-platelet haemocomponents for topical use: regenerative potentiality.
Wider and wider is the interest in different clinical ambits in the application of haemocomponents produced from peripheral blood for regenerative purposes. These are mainly made up of concentrated platelets capable of releasing locally growth factor (GF) that stimulates tissue regeneration. Our group has devised a method to produce a new leucocyte-platelet haemocomponent enriched in fibrinogen that integrates the GF stimulus with the presence of cells involved in the regenerative processes: monocytes and stem cells. The use of the cell separator to collect these haemocomponents from peripheral blood has allowed us to realize a safe standardized product, with good regenerative potentiality and reasonable costs. This is obtained by modifying some parameters of separation, and without cell manipulation.
Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale San Martino di Belluno, viale Europa 22, 32100, Belluno, Italy. gaetano.caloprisco@ulss.belluno.it
Gaetano
G
Caloprisco
Alessio
A
Borean
D000287:Administration, Topical; D018952:Antigens, CD34 / Q000378:metabolism; D001792:Blood Platelets / Q000737:chemistry* / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D007962:Leukocytes / Q000737:chemistry* / Q000378:metabolism; D012038:Regeneration / Q000187:drug effects*
D018952:Antigens, CD34; D036341:Intercellular Signaling Peptides and Proteins