Pyrinodemins E and F, new 3-alkylpyridine alkaloids from sponge Amphimedon sp.
Two new 3-alkylpyridine alkaloids, pyrinodemins E (1) and F (2), were isolated from an Okinawan marine sponge Amphimedon sp. and the structures of 1 and 2 were elucidated on the basis of spectroscopic data. Pyrinodemins E (1) and F (2) were novel 3-alkylpyridine alkaloids possessing a 4-(methoxyamino)piperidinone moiety and an indol-3-glyoxylamide moiety, respectively. Pyrinodemin E (1) showed cytotoxicity against P388 and L1210 murine leukemia cells.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Ken'ichi
K
Kura
Takaaki
T
Kubota
Jane
J
Fromont
Jun'ichi
J
Kobayashi
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
D000470:Alkaloids; D011725:Pyridines; C557262:pyrinodemin E; C557263:pyrinodemin F; C023666:pyridine