Calcium based non-viral gene delivery: an overview of methodology and applications.
Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and nonviral vectors, were found to have a positive effect on gene transfer especially when incorporated in the colloidal particulate systems. This review elaborates on various successful methods of using calcium phosphate nanoparticles in gene delivery, which are considered an advancing approach to gene delivery.
National Nutrition and Food Technology Research Institute, Shahid Beheshti Medical University, Tehran, Iran. kiankh@yahoo.com
Kianoush
K
Khosravi-Darani
Mohamaad Reza
MR
Mozafari
Ladan
L
Rashidi
Mehrdad
M
Mohammadi
D000818:Animals; D002130:Calcium Phosphates / Q000008:administration & dosage* / Q000737:chemistry; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D008055:Lipids / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry
D002130:Calcium Phosphates; D008055:Lipids