[Control of bone remodeling by nervous system. The role of serotonin in the regulation of bone metabolism].
There is increasing evidence for a contribution of serotonin to the regulation of bone metabolism. In the periphery, gut derived serotonin (GDS) regulates osteoblast proliferation and bone formation. In the brain, brain derived serotonin regulates bone mass through sympathetic nervous system. In addition, inhibition of GDS biosynthesis can treat osteoporosis in ovariectomized rodents by increasing bone formation. The emerging evidence has suggested that inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis in humans.
Department of Genetics and Development, Columbia University, NY, USA.
Hiroyuki
H
Inose
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D049109:Cell Proliferation; D003863:Depression; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000502:physiology; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D051379:Mice; D058990:Molecular Targeted Therapy; D010006:Osteoblasts / Q000166:cytology; D010012:Osteogenesis; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology; D012701:Serotonin / Q000096:biosynthesis / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D000928:Antidepressive Agents; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; C555483:Lrp5 protein, mouse; D012701:Serotonin