Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
Variation in antidepressive medication response according to 5-HT2A genotype has been reported in several studies. Temperament has been proposed to be one of the vulnerability factors in mood and anxiety disorders. We studied temperament profiles of 98 patients with major depression and explored the interaction between Temperament and Character Inventory (TCI) temperament dimensions, 5-HT2A genotype (SNPs rs6311, rs6313 and rs7997012) and treatment response. No interactive effects for TCI temperament dimensions and 5-HT2A genotypes on antidepressive treatment response were found.
Medical School, University of Tampere, 33014 Tampere, Finland. kadriandre@hot.ee
Kadri
K
Andre
Olli
O
Kampman
Eija
E
Setälä-Soikkeli
Merja
M
Viikki
Outi
O
Poutanen
Timo
T
Nuolivirta
Nina
N
Mononen
Terho
T
Lehtimäki
Esa
E
Leinonen
Ari
A
Illi
D000328:Adult; D000368:Aged; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013694:Temperament / Q000187:drug effects / Q000502:physiology*; D055815:Young Adult
D044402:Receptor, Serotonin, 5-HT2A; D017367:Selective Serotonin Reuptake Inhibitors