Polymorphism A1/A2 in the cell surface integrin subunit β3 and disturbance of implantation and placentation in women with recurrent pregnancy loss.
Polymorphism A1/A2 in the β3 subunit of integrins αIIb/β3 and αV/β3 is implicated in the risk of development of embryonic and fetal recurrent pregnancy loss (RPL). In 191 women with RPL, polymorphism A1/A2 was statistically significantly associated with RPL at <10 weeks of gestation (29.3% versus 16.4% in controls), but it was much more pronounced in 67 women with RPL between 10 and 20 weeks of gestation (41.8%), illustrating its role in recurrent fetal loss.
Department of Chemistry and Biochemistry, University of Medicine, Pleven, Bulgaria. mdivanov@gmail.com
Petar D
PD
Ivanov
Regina S
RS
Komsa-Penkova
Emiliana I
EI
Konova
Tsvetomira M
TM
Tsvyatkovska
Katia S
KS
Kovacheva
Maria N
MN
Simeonova
Stoyan Y
SY
Tanchev
D000026:Abortion, Habitual / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000483:Alleles; D000954:Antigens, Surface / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D016022:Case-Control Studies; D010064:Embryo Implantation / Q000235:genetics*; D020964:Embryo Loss / Q000235:genetics / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000473:pathology; D039661:Integrin beta3 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D010929:Placentation / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000502:physiology; D011247:Pregnancy; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D000954:Antigens, Surface; D039661:Integrin beta3; D021122:Protein Subunits