Regulation and biological function of the liver-specific miR-122.
miRNAs (microRNAs) are important regulators of gene expression. In higher eukaryotes, the tightly controlled expression of different miRNAs, each of which regulates multiple target mRNAs, is crucial for the maintenance of tissue type and the control of differentiation. miR-122 is a highly liver-specific miRNA that is important in hepatitis C virus infection, cholesterol metabolism and hepatocellular carcinoma. In the present review, we discuss the effects of miR-122 on liver physiology and pathology. Recent evidence of pathways involved in the regulation of miR-122 expression is also considered.
Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Andrew P
AP
Lewis
Catherine L
CL
Jopling
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002784:Cholesterol / Q000378:metabolism; D002940:Circadian Rhythm / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism; D006526:Hepatitis C / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000502:physiology*; D008113:Liver Neoplasms / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis
C531907:MIRN122 microRNA, human; D035683:MicroRNAs; D002784:Cholesterol