CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1.
As a principle receptor to β-glucan in the Candida albicans cell wall, Dectin-1 performs recognition specifically and its mechanisms are diverse in different situations. With a view to developing certain antifungal targeted drugs, this review provides new insights into the novel immune signaling pathways induced by Dectin-1, especially the novel understandings of CARD9 in the Syk-dependent NF-κB pathway, and of Raf-1 in the Syk-independent NF-κB signaling pathway.
Department of Stomatology, Second Affiliated Hospital, Medicine College, Zhejiang University, Hangzhou 310009, China.
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D000818:Animals; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics / Q000378:metabolism; D002176:Candida albicans / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D002177:Candidiasis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000276:immunology* / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000072377:Syk Kinase; D047071:beta-Glucans / Q000276:immunology / Q000378:metabolism; D000099181:Dectin-1
D053468:CARD Signaling Adaptor Proteins; D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; D008565:Membrane Proteins; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D011505:Protein-Tyrosine Kinases; D019908:Proto-Oncogene Proteins c-raf; D000072377:Syk Kinase; D047071:beta-Glucans; D000099181:Dectin-1; C000606896:SYK protein, human; C000606897:Syk protein, mouse