Study of normal human serum proteomic profile under conditions of hyperbaric oxygen-nitrogen-argon exposure.
The dynamics of changes in serum proteome was studied under conditions of experimental 9-day seclusion in a pressure chamber at 5 m H(2)O pressure with modified gaseous environment. The proteomic profile for the molecular weight range of 1000-17,000 Da changed by 75%. Increased content of acute phase proteins (complement components, inter-α-trypsin inhibitor, and high-molecular-weight kininogen) was observed on day 1 of the experiment before the exposure. On day 9 of exposure, the peaks of AII, CI, and CII apolipoproteins decreased and angiotensin II peak increased.
Laboratory 0051, Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia. natik_1777@rambler.ru
N A
NA
Pakharukova
L Kh
LKh
Pastushkova
Yu A
YA
Popova
O P
OP
Trifonova
I M
IM
Larina
D000209:Acute-Phase Proteins / Q000032:analysis; D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D000804:Angiotensin II / Q000097:blood; D001053:Apolipoproteins / Q000097:blood; D001128:Argon / Q000494:pharmacology*; D001798:Blood Proteins / Q000032:analysis*; D006801:Humans; D006931:Hyperbaric Oxygenation; D013058:Mass Spectrometry; D008875:Middle Aged; D009584:Nitrogen / Q000494:pharmacology*; D011312:Pressure; D040901:Proteomics
D000209:Acute-Phase Proteins; D001053:Apolipoproteins; D001798:Blood Proteins; D000804:Angiotensin II; D001128:Argon; D009584:Nitrogen