Asymmetric total synthesis and structural elucidation of NFAT-68.
Total synthesis of NFAT-68 (7) has been achieved and its relative stereochemistry has been determined. A key step thereof is the utilization of the chelation-controlled vinylogous Mukaiyama aldol reaction (VMAR) to stereoselectively synthesize the syn-aldol product 8. This developed chemistry is anticipated to have wider application in total syntheses of many other natural products.
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry, Peking University, Beijing 10087, China.
Lin
L
Wang
Yumeng
Y
Xi
Shouliang
S
Yang
Rong
R
Zhu
Yufan
Y
Liang
Jiahua
J
Chen
Zhen
Z
Yang
D018360:Crystallography, X-Ray; D006873:Hydroquinones / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D006873:Hydroquinones; C094350:NFAT 68