A fourth scale sensitive to the magnetic field; intermolecular frequency symmetry in a specific interaction between protein and low-molecular compound.
We found a new method that a specific interaction between prion, i.e., high-molecular compound, and Cp-60, i.e., low-molecular one, could be successfully elucidated with intermolecular frequency symmetry (IFS). To accomplish this, the former sequence is analyzed with a sequence Fourier analysis used average nuclear (N) resonant frequency scale as a fourth one, and the latter structure with a ¹³C-NMR software. Further, such the symmetry could be observed in a specific interaction between a segment of human immunodeficiency virus (HIV)gag and PA-457 or between 1918 neuraminidase and peramivir. Therefore, the IFS rule seems to be evolutionarily conserved as a necessary condition even in a specific protein-organic compound interaction.
BioFrontier Institute Inc., Kanagawa, Japan. fukazawa@kanagawa-iri.go.jp
Naganori
N
Numao
Tetsuya
T
Fukui
Yoshiyuki
Y
Fukazawa
D000146:Acids, Carbocyclic; D000631:Aminopyridines / Q000737:chemistry; D003517:Cyclopentanes / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D009570:Nitriles / Q000737:chemistry; D011328:Prions / Q000737:chemistry*; D011485:Protein Binding; D012984:Software; D013386:Succinates / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000737:chemistry; D053978:Pentacyclic Triterpenes
D000146:Acids, Carbocyclic; D000631:Aminopyridines; D003517:Cyclopentanes; D006146:Guanidines; D009570:Nitriles; D011328:Prions; D013386:Succinates; D014315:Triterpenes; D054301:gag Gene Products, Human Immunodeficiency Virus; C410007:Cp 60 compound; C414210:peramivir; C479935:bevirimat; D053978:Pentacyclic Triterpenes