Salvianolic acid B attenuates brain damage and inflammation after traumatic brain injury in mice.
Salvianolic acid B (SalB), a bioactive compound isolated from the Chinese medicinal herb Danshen, has been shown to exert various anti-oxidative and anti-inflammatory activities in in vitro and in vivo studies. Here, we investigated the protective effects of SalB on traumatic brain injury (TBI) in mice. When administered within 2 h after TBI onset, SalB (25 mg/kg) reduced brain edema, lesion volume and motor functional deficits, and improved spatial learning and memory abilities. Moreover, SalB treatment inhibited the neutrophil infiltration and microglial activation at 48 h after TBI. Enzyme-linked immunosorbent assay (ELISA) for brain tissue homogenates was performed at 24 h after TBI to evaluate the expression of inflammation-related cytokines. The results showed that SalB suppressed the expression of pro-inflammatory cytokines TNF-α and IL-1β, whereas enhanced the expression of anti-inflammatory cytokines IL-10 and TGF-β1. All of these findings extended the protective role of SalB in the model of TBI and suggested that these protective effects might be associated with its anti-inflammatory activities. Thus SalB may have therapeutic potential for patients with TBI and perhaps other forms of acute brain injury.
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, People's Republic of China.
Tao
T
Chen
Wenbo
W
Liu
Xiaodong
X
Chao
Lei
L
Zhang
Yan
Y
Qu
Junli
J
Huo
Zhou
Z
Fei
D000818:Animals; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D001929:Brain Edema / Q000188:drug therapy; D001930:Brain Injuries / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D016753:Interleukin-10 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D013028:Space Perception / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D053630:Depsides
D001572:Benzofurans; D016753:Interleukin-10; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; C076944:salvianolic acid B; D053630:Depsides