[The novel views on the patomechanism of ischemic stroke].
Stroke is the third cause of death and the first cause of handicap. Current knowledge about stroke allows to apply the effective methods of treatment or prophylaxis. Eighteen five percent of all strokes are ischemic (IS), 15% are haemmorrhagic (HS). Unequal oxygen supply and the changes occurring in the macro and microcirculation results in the division of ischemic focus into the two areas; central core with an irreversible destruction of brain cells and penumbra, "semi-shadow area" around the core. The insufficient blood flow within the penumbra manifests the clinical symptoms of IS however the changes are reversible after the restoration of the correct circulation. We assumed five pathways leading to neurons' death: excitotoxicity and ionic imbalance, oxidative stress, inflamamation, peri-infract depolarization and apoptosis. This review briefly describes biochemical mechanism of IS development.
Katedra i Klinika Neurologii Uniwersytetu Medycznego w Lublinie. j.bielewicz@op.pl
Joanna
J
Bielewicz
Jacek
J
Kurzepa
Monika
M
Łagowska-Lenard
Halina
H
Bartosik-Psujek
D002545:Brain Ischemia / Q000453:epidemiology* / Q000503:physiopathology*; D015897:Comorbidity; D006801:Humans; D020521:Stroke / Q000453:epidemiology* / Q000503:physiopathology*