[Serum anti-endomysium antibodies (AEA) in the diagnostic algorithm of coeliac disease].
The diagnostic relevance of serum anti-endomysium antibodies (AEA) in patients with celiac disease is discussed. A group of 23 newly diagnosed patients, i.e., seven patients with mild AEA positivity (+), nine patients with intermediate AEA positivity (++) and seven patients with strong AEA positivity (+++), was selected. The AEA reactivity was evaluated semiquantitatively. Celiac disease and AEA are less than 100% correlated. The final diagnosis has to be confirmed by histopathology of small intestine biopsy specimens. The available targeted screening is an alternative with a potential for the detection of atypical forms of celiac disease. Another alternative for early diagnosis is the detection of intraepithelial lymphocyte activity or of lymphocyte mediators.
Czech University of Life Sciences, Praha. pmakovicky@email.cz
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D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology*; D055815:Young Adult
D001323:Autoantibodies; D015415:Biomarkers