Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers.
A novel series of diphenylbutylpiperidines as autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.
State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Gang
G
Chen
Hongguang
H
Xia
Yu
Y
Cai
Dawei
D
Ma
Junying
J
Yuan
Chengye
C
Yuan
D001343:Autophagy; D045744:Cell Line, Tumor; D006801:Humans; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D010880:Piperidines; C032727:piperidine