Bedside lung mechanics predict survival in hypoplastic lung disease.
Newer bedside pulmonary mechanics using conventional ventilators allow for CONTINUOUS serial determinations of tidal volume (V(T)). We sought to determine whether the degree of pulmonary hypoplasia could be measured using bedside pulmonary graphics and whether survival could be predicted in potential extracorporeal membrane oxygenation (ECMO) candidates. Data on all neonates considered for or treated with ECMO at our center between April 2000 and March 2005 were collected. The "maximal bedside V(T)" was measured daily at the peak pressure where "beaking" began with a peak end expiratory pressure of 4 cm H(2)O. Twenty-two patients were reviewed: eight ECMO plus fourteen similar patients in whom the threshold for ECMO intervention was not achieved. Independent of need for ECMO, any patient with V(T) of < 3 mL/kg or < 0.2 mL/cm length died ( N = 4). All other measures of lung capacity or blood gas assessments were less valuable than V(T) in predicting survival. We conclude that bedside V(T) can be easily measured and that values < 3 mL/kg or < 0.2 mL/cm length demarcate severe lung hypoplasia, which in our patient population was incompatible with survival. We speculate that bedside V(T) may assist in evaluating the utility of ECMO.
Division of Newborn Medicine, Department of Pediatrics, Maria Fareri Children's Hospital, Westchester Medical Center, New York Medical College, Valhalla, USA.
Abdul
A
Haleem
Muhammad T
MT
Zia
Ravi
R
Mishra
Lance A
LA
Parton
Gustavo
G
Stringel
Edmund F
EF
La Gamma
D000208:Acute Disease; D001784:Blood Gas Analysis; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000401:mortality; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009929:Organ Size; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications / Q000401:mortality; D011237:Predictive Value of Tests; D011650:Pulmonary Alveoli / Q000002:abnormalities; D012131:Respiratory Insufficiency / Q000097:blood / Q000150:complications / Q000401:mortality* / Q000503:physiopathology; D016019:Survival Analysis; D013990:Tidal Volume