Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent.
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the anti-inflammatory agent. This methodology will ultimately lead to new biomaterials for site-specific drug delivery.
Department of Chemistry, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, United States.
Xinming
X
Li
Jiayang
J
Li
Yuan
Y
Gao
Yi
Y
Kuang
Junfeng
J
Shi
Bing
B
Xu
D000636:Aminosalicylic Acids / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry*; D019804:Mesalamine / Q000737:chemistry; D008954:Models, Biological; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry*; D010084:Oxidation-Reduction; D044367:Phase Transition; D011355:Prodrugs; D014867:Water / Q000737:chemistry
D000636:Aminosalicylic Acids; D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D020100:Hydrogels; D011355:Prodrugs; D014867:Water; D019804:Mesalamine; C032587:olsalazine