[Superficial acral fibromyxoma: three cases].
BACKGROUND
in this report of three new cases of superficial acral fibromyxoma (SAF), we discuss the clinicopathological features of this acral fibrous tumour as well as the differential diagnoses for hard nodules affecting the extremities.


METHODS
these three lesions involved the standard presentation of a large solitary flesh coloured nodule causing deformation of a toenail or a fingernail. Biopsy showed the presence within a fibromyxoid tumour of proliferating fusiform cells having no atypical features and expressing CD 34 diffusely, and in more focal and less consistent fashion, epithelial membrane antigen (EMA) and CD 99. FISH testing for translocation t(17; 22) proved negative.


CONCLUSIONS
this fairly common acral fibrous tumour is poorly known and in certain cases histology results may suggest myxoid dermatofibrosarcoma, which carries a completely different prognosis.
Service de Dermatologie, Hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac Cedex, France. olivier.cogrel@chu-bordeaux.fr
O
O
Cogrel
S
S
Stanislas
J-M
JM
Coindre
P
P
Guillot
M
M
Beylot-Barry
M-S
MS
Doutre
B
B
Vergier
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D062109:Dermatologic Surgical Procedures; D005260:Female; D005350:Fibroma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005385:Fingers / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D009260:Nail Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014034:Toes / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor