'2+1' tricarbonyltechnetium(I)/tricarbonylrhenium(I) mixed-ligand complexes with methyl thiosalicylate and isocyanide ligands as potential precursors of radiopharmaceuticals.
The complexes of [(99m)Tc]-tricarbonyltechnetium(I) and [(188)Re]-tricarbonylrhenium(I), of the '2+1' type, with methyl thiosalicylate as an anionic bidentate ligand and with either tert-butyl 3-isocyanopropionate or glycine-glycine-tyrosine 4-isocyanobutyrate as monodentate ligands, have been prepared on the n.c.a. scale. The complexes exhibit different lipophilicity and high stability in neutral aqueous solutions. Based on the results of the challenge experiment with histidine, cysteine and glutathione the studied complexes might be considered to be promising models for radiopharmaceutical precursors.
Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland. p.kozminski@ichtj.waw.pl
Przemysław
P
Koźmiński
Ewa
E
Gniazdowska
Leon
L
Fuks
Sylwia
S
Kowalska
D017953:Isocyanates / Q000737:chemistry; D008024:Ligands; D009842:Oligopeptides / Q000737:chemistry; D015609:Organotechnetium Compounds / Q000138:chemical synthesis*; D011422:Propionates / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012211:Rhenium / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013667:Technetium; D014233:Tricarboxylic Acids / Q000138:chemical synthesis*
D017953:Isocyanates; D008024:Ligands; D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011422:Propionates; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012459:Salicylates; D013438:Sulfhydryl Compounds; D014233:Tricarboxylic Acids; C546838:tert-butyl 3-isocyanopropionate; D012211:Rhenium; D013667:Technetium