Regulatory role of supramolecular alcohol dehydrogenase and lactate dehydrogenase complex in cell mitochondria.
The existence of a supramolecular alcohol dehydrogenase-lactate dehydrogenase complex was demonstrated. Enzyme activities were evaluated in a preparation of mitochondrial membranes from mouse liver. The role of the enzyme complex (alcohol dehydrogenase-lactate dehydrogenase) in the regulation of pyruvate and acetaldehyde metabolism in the cell was studied.
Institute of Traumatology and Orthopedics, Ministry of Health Care and Social Development of the Russian Federation, Nizhny Novgorod, Russia.
Yu V
YV
Zimin
A G
AG
Solovyova
D000079:Acetaldehyde / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D051379:Mice; D008930:Mitochondria, Liver / Q000201:enzymology*; D008954:Models, Biological; D019289:Pyruvic Acid / Q000378:metabolism
D019289:Pyruvic Acid; D000426:Alcohol Dehydrogenase; D007770:L-Lactate Dehydrogenase; D000079:Acetaldehyde