Influences of the size and hydroxyl number of fullerenes/fullerenols on their interactions with proteins.
In this study, we systematically investigated the interaction of fullerenes/fullerenols with model proteins using a widely used computational docking program Autodock 4.0. We found that pi-pi interaction existed in all the proteins-fullerene/fullerenol systems investigated here, and contributed greatly to the overall interaction energy. We also found that with the increase of the carbon cage size, the binding strength between proteins and fullerenes/fullerenols increased constantly. In addition, our results show that functionalization of fullerenes with polar groups, such as hydroxyl groups, decreases the binding between proteins and fullerene derivatives. In other words, the more hydroxyl groups on fullerenols, the weaker binding between proteins and fullerenols.
Department of Chemistry, Capital Normal University, Beijing 100048, China.
Xian
X
Wu
Sheng-Tao
ST
Yang
Haifang
H
Wang
Luyao
L
Wang
Wenxiang
W
Hu
Aoneng
A
Cao
Yuanfang
Y
Liu
D019295:Computational Biology; D037741:Fullerenes / Q000737:chemistry* / Q000378:metabolism; D016333:HIV Protease / Q000737:chemistry / Q000378:metabolism; D056004:Molecular Dynamics Simulation; D009113:Muramidase / Q000737:chemistry / Q000378:metabolism; D010316:Particle Size; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012259:Ribonuclease, Pancreatic / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
D037741:Fullerenes; D011506:Proteins; C108127:fullerenol; D012259:Ribonuclease, Pancreatic; D009113:Muramidase; D016333:HIV Protease