Highly effective generic adjuvant systems for orphan or poverty-related vaccines.
Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA.
Mangala
M
Rao
Kristina K
KK
Peachman
Qin
Q
Li
Gary R
GR
Matyas
Sathish B
SB
Shivachandra
Richard
R
Borschel
Venee I
VI
Morthole
Carmen
C
Fernandez-Prada
Carl R
CR
Alving
Venigalla B
VB
Rao
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000009:adverse effects; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000881:Anthrax / Q000517:prevention & control; D022122:Anthrax Vaccines / Q000009:adverse effects / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood; D057134:Antibodies, Neutralizing / Q000097:blood; D008081:Liposomes / Q000008:administration & dosage* / Q000009:adverse effects; D008253:Macaca mulatta; D018419:Primate Diseases / Q000517:prevention & control; D016019:Survival Analysis
D000276:Adjuvants, Immunologic; D022122:Anthrax Vaccines; D000907:Antibodies, Bacterial; D057134:Antibodies, Neutralizing; D008081:Liposomes; D000536:Aluminum Hydroxide