TRP channels and their implications in metabolic diseases.
The transient receptor potential (TRP) channel superfamily is composed of 28 nonselective cation channels that are ubiquitously expressed in many cell types and have considerable functional diversity. Although changes in TRP channel expression and function have been reported in cardiovascular disease and renal disorders, the pathogenic roles of TRP channels in metabolic diseases have not been systemically reviewed. In this review, we summarised the distribution of TRP channels in several metabolic tissues and discussed their roles in mediating and regulating various physiological and pathophysiological metabolic processes and diseases including diabetes, obesity, dyslipidaemia, metabolic syndrome, atherosclerosis, metabolic bone diseases and electrolyte disturbances. This review provides new insight into the involvement of TRP channels in the pathogenesis of metabolic disorders and implicates these channels as potential therapeutic targets for the management of metabolic diseases.
Department of Hypertension and Endocrinology, Centre for Hypertension and Metabolic Diseases and Chongqing Institute of Hypertension, Daping Hospital, Third Military Medical University, Chongqing, 400042, China. zhuzm@yahoo.com
Zhiming
Z
Zhu
Zhidan
Z
Luo
Shuangtao
S
Ma
Daoyan
D
Liu
D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D001851:Bone Diseases, Metabolic / Q000503:physiopathology; D002211:Capsaicin / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000503:physiopathology; D050171:Dyslipidemias / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008659:Metabolic Diseases / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000503:physiopathology; D009765:Obesity / Q000503:physiopathology; D050051:Transient Receptor Potential Channels / Q000502:physiology*
D007328:Insulin; D050051:Transient Receptor Potential Channels; D002211:Capsaicin