Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials.
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.
Division of Clinical Immunology and Rheumatology, Room F4-218, Academic Medical Center/University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
Marleen G H
MG
van de Sande
Danielle M
DM
Gerlag
Beatrijs M
BM
Lodde
Lisa G M
LG
van Baarsen
Stefano
S
Alivernini
Veronica
V
Codullo
Ioana
I
Felea
Elsa
E
Vieira-Sousa
Ursula
U
Fearon
Richard
R
Reece
Carlomaurizio
C
Montecucco
Douglas J
DJ
Veale
Costantino
C
Pitzalis
Paul
P
Emery
Lars
L
Klareskog
Iain B
IB
McInnes
Paul P
PP
Tak
D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology*; D001182:Arthroscopy / Q000379:methods; D001706:Biopsy / Q000379:methods* / Q000592:standards; D002986:Clinical Trials as Topic / Q000592:standards; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D015337:Multicenter Studies as Topic / Q000592:standards; D013583:Synovial Membrane / Q000473:pathology*; D013585:Synovitis / Q000473:pathology*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods
D018501:Antirheumatic Agents