Immunohistochemistry for 2',3'-cyclic nucleotide-3'-phosphohydrolase in 63 bovine peripheral nerve sheath tumors.
To establish a simple and uniform classification of bovine peripheral nerve sheath tumors (PNSTs), 63 tumors from 44 cattle were examined histologically and immunohistochemically with antibodies against S100 protein and 2',3'-cyclic nucleotide-3'-phosphohydrolase (CNPase). Immunohistochemically, all the tumors were positive for S100 protein, CNPase, or both. Four types of PNST were recognized: 35 schwannomas, 9 neurofibromas, 14 hybrid (neurofibroma-schwannoma) tumors, and 5 malignant PNSTs. Axons were identified by immunohistochemistry for neurofilament in a proportion of tumors of each type of PNST. In conclusion, bovine PNSTs commonly have both schwannomatous and neurofibromatous areas. Moreover, the Schwann cell markers S100 protein and CNPase, in combination with antibodies against neurofilament, are valuable diagnostic tools to classify bovine PNSTs.
Department of Veterinary Disease Biology, Section of Pathology, Faculty of Life Sciences, University of Copenhagen, Ridebanevej 3, DK-1870 Frederiksberg C, Denmark. ple@life.ku.dk
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AB
Nielsen
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HE
Jensen
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PS
Leifsson
D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D018317:Nerve Sheath Neoplasms / Q000145:classification / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D010727:Phosphoric Diester Hydrolases / Q000235:genetics / Q000378:metabolism*; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism
D009418:S100 Proteins; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase