[Effects of Xuefu Zhuyu decoction on EPCs function].
OBJECTIVE
To observe the effect on EPCs function by Xuefu Zhuyu Decoction.


METHODS
After induced by serial concentrations of Xuefu Zhuyu Decoction-contained serum (XZDCS) and blank serum, EPCs proliferation, migration, adhesion and uptake function were detected by MTT, Boyden chamber, adhesion and uptake of ac-LDL respectively.


RESULTS
Compared with the control group, 15% and 10% XZDCS could elevate the cell regeneration for 24 h and 48 h respectively. Both concentrations could improve the EPCs migration and adhesion for all 24, 48, 72 h and uptake of ac-LDL only 48 h. But 10% XZDCS could last effect on uptake of ac-LDL to 72 h and 5% XZDCS converted the inhibition of cell adhesion in the first 24 h to promotion in the next 48 - 72 h.


CONCLUSIONS
Xuefu Zhuyu Decoction could induce EPCs differentiation into EC to angiogenesis by promoting its proliferation, migration, adhesion and uptake function.
College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China. gd1026@yahoo.com.cn
Dong
D
Gao
Li-Ya
LY
Wu
Yu-Huan
YH
Jiao
Wen-Yuan
WY
Chen
Yan
Y
Chen
Bo
B
Lu
Jun
J
Song
Ke-Ji
KJ
Chen
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004727:Endothelium / Q000166:cytology*; D005260:Female; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*
D043925:Angiogenesis Inducing Agents; D004365:Drugs, Chinese Herbal; C513826:Xue-Fu-Zhu-Yu decoction