In vitro inhibition of bacterial growth by iron chelators.
The antimicrobial activity of the iron(III)-selective 3-hydroxypyridin-4-one chelators, CP251(1) and CP252(2), was evaluated in comparison with that of diethylenetriamine-penta acetic acid (3). CP251 was found to exhibit an inhibitory effect on the growth of both Gram-positive and Gram-negative bacteria. CP251 may find application in the treatment of external infections such as those associated with wounds.
Faculty of Life Science and Biotechnology, Ningbo University, Ningbo, Zhejiang, China.
Di-Hong
DH
Qiu
Zhu-Liang
ZL
Huang
Tao
T
Zhou
Chen
C
Shen
Robert C
RC
Hider
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development*; D002614:Chelating Agents / Q000378:metabolism*; D006131:Growth Inhibitors / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000378:metabolism*
C121031:3-hydroxypyridin-4-one; D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D006131:Growth Inhibitors; D011725:Pyridines; D007501:Iron