Immunogenetics features and genomic lesions in splenic marginal zone lymphoma.
Splenic marginal zone lymphomas (MZL) express mutated (M)) or unmutated (U)) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including poor prognosticators. Frequencies differed among cases bearing individual IGHV genes or lambda light chains. In conclusion, SMZL comprises subgroups based on genetic abnormalities and immunogenetic status. Genomic lesion frequency differed and was higher in U-IGHV cases, possibly affecting the outcome.
Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.
Andrea
A
Rinaldi
Francesco
F
Forconi
Luca
L
Arcaini
Michael
M
Mian
Elena
E
Sozzi
Silvia
S
Zibellini
Luca
L
Baldini
Silvia
S
Franceschetti
Gianluca
G
Gaidano
Roberto
R
Marasca
Manuela
M
Mollejo
Miguel A
MA
Piris
Alessandra
A
Tucci
Fabio
F
Facchetti
Govind
G
Bhagat
Riccardo D
RD
Favera
Paola M V
PM
Rancoita
Emanuele
E
Zucca
Ivo
I
Kwee
Francesco
F
Bertoni
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D013160:Splenic Neoplasms / Q000235:genetics* / Q000276:immunology; D016019:Survival Analysis
D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region