Gaining a foothold: how HIV avoids innate immune recognition.
During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in infected CD4 T cells and macrophages by harnessing a host cytoplasmic DNase TREX1 to digest nonproductive HIV reverse transcripts.
Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States.
Nan
N
Yan
Judy
J
Lieberman
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission; D006801:Humans; D007113:Immunity, Innate; D012367:RNA, Viral / Q000276:immunology
D012367:RNA, Viral