[88 years old woman with acute muscular weakness and diffuse muscular pain: have you thought about the drugs?].
An 88 years old woman was admitted for muscular pain and weakness. She was under a treatment of simvastatin and was recently prescribed clarithromycin for a lung infection. The diagnosis of statin induced rhabdomyolysis by drug interaction was made. The evolution is good with eviction of the statin and aggressive hydratation. This case shows how important it is to know the risks factors and drug interactions predisposing to statin-induced myopathy.
Service de Médecine Interne, CHUV, Lausanne.
Ch
Ch
Arnold
O
O
Lamy
N
N
Hagmann
D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D018908:Muscle Weakness / Q000139:chemically induced*; D010146:Pain / Q000139:chemically induced*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis*; D019821:Simvastatin / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000924:Anticholesteremic Agents; D019821:Simvastatin; D017291:Clarithromycin