Oxytocin increases autonomic cardiac control: moderation by loneliness.
The current study examined the role of perceived social isolation in moderating the effects of oxytocin on cardiac autonomic control in humans. Intranasal administration of 20 IU oxytocin resulted in a significant increase in autonomic (parasympathetic and sympathetic) cardiac control. Specifically, oxytocin increased high frequency heart rate variability, a relatively pure measure of parasympathetic cardiac control, and decreased pre-ejection period, a well-validated marker of enhanced sympathetic cardiac control. Derived metrics of autonomic co-activity and reciprocity revealed that oxytocin significantly increased overall autonomic cardiac control. Furthermore, the effects of oxytocin on cardiac autonomic control were significantly associated with loneliness ratings. Higher levels of loneliness were associated with diminished parasympathetic cardiac reactivity to intranasal oxytocin. The effects of OT on autonomic cardiac control were independent of any effects on circulating pro-inflammatory cytokine or stress hormone levels. Thus, lonely individuals may be less responsive to the salubrious effects of oxytocin on cardiovascular responsivity.
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA. norman.106@osu.edu
Greg J
GJ
Norman
John T
JT
Cacioppo
John S
JS
Morris
William B
WB
Malarkey
Gary G
GG
Berntson
A Courtney
AC
Devries
D000328:Adult; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood; D016207:Cytokines / Q000097:blood; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008132:Loneliness / Q000523:psychology*; D008297:Male; D008954:Models, Biological; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D011237:Predictive Value of Tests; D013997:Time Factors; D055815:Young Adult
D002395:Catecholamines; D016207:Cytokines; D010120:Oxytocics; D010121:Oxytocin; D006854:Hydrocortisone