Osteoblast physiology in normal and pathological conditions.
Osteoblasts are mononucleated cells that are derived from mesenchymal stem cells and that are responsible for the synthesis and mineralization of bone during initial bone formation and later bone remodelling. Osteoblasts also have a role in the regulation of osteoclast activity through the receptor activator of nuclear factor κ-B ligand and osteoprotegerin. Abnormalities in osteoblast differentiation and activity occur in some common human diseases such as osteoporosis and osteoarthritis. Recent studies also suggest that osteoblast functions are compromised at sites of focal bone erosion in rheumatoid arthritis.
Rheumatology Clinic, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy.
Anna
A
Neve
Addolorata
A
Corrado
Francesco Paolo
FP
Cantatore
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D010010:Osteoclasts / Q000378:metabolism; D010012:Osteogenesis
D016328:NF-kappa B