Modulatory effects of theta burst stimulation on cerebellar nonsomatic functions.
Clinical and functional imaging studies suggest that the cerebellar vermis is involved in the regulation of a range of nonsomatic functions including cardiovascular control, thirst, feeding behavior, and primal emotions. Cerebello-hypothalamic circuits have been postulated to be a potential neuroanatomical substrate underlying this modulation. We tested this putative relationship between the cerebellar vermis and nonsomatic functions by stimulating the cerebellum noninvasively via neuronavigated transcranial magnetic stimulation. In this randomized, counter-balanced, within-subject study, intermittent theta burst stimulation (TBS) was applied on three different days to the vermis and the right and left cerebellar hemispheres of 12 right-handed normal subjects with the aim of modulating activity in the targeted cerebellar structure. TBS-associated changes were investigated via cardiovascular monitoring, a series of emotionally arousing picture stimuli, subjective analog scales for primal emotions, and the Profile of Mood States test. All 36 sessions of cerebellar stimulation were tolerated well without serious adverse events. Cardiovascular monitoring pointed to a mild but significant decrease in heart rate subsequent to vermal stimulation; no changes were detected in systolic or diastolic blood pressure measurements. Subjective ratings detected a significant increase in Thirst and a trend toward increased Appetite following vermal stimulation. These observations are consistent with existing neurophysiological and neuroimaging data indicating a role for the cerebellum in the regulation of visceral responses. In conjunction with the modulatory function of the cerebellum, our results suggest a role for the vermis in somatovisceral integration likely through cerebello-hypothalamic pathways. Further research is warranted to elucidate the potential mechanisms underlying the cerebellar modulation of nonsomatic functions.
Harvard Medical School, Boston, MA, USA.
Asli
A
Demirtas-Tatlidede
Catarina
C
Freitas
Alvaro
A
Pascual-Leone
Jeremy D
JD
Schmahmann
D000328:Adult; D000704:Analysis of Variance; D001066:Appetite / Q000502:physiology; D001931:Brain Mapping; D002320:Cardiovascular Physiological Phenomena; D002531:Cerebellum / Q000033:anatomy & histology / Q000502:physiology*; D004644:Emotions / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D013894:Thirst / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*