The diagnostic and molecular characteristics of malignant mesothelioma and ovarian/peritoneal serous carcinoma.
Malignant mesothelioma and ovarian/peritoneal serous carcinoma are two of the most common tumours affecting the serosal cavities. Unlike other malignant tumours diagnosed at this anatomical site, such as lung and breast carcinoma, malignant mesothelioma and serous carcinoma share a common histogenesis, may be difficult to differentiate morphologically, and co-express many of the diagnostic markers used by cytopathologists in effusion diagnosis. Selected markers have nevertheless shown sufficient sensitivity and specificity to differentiate serous carcinoma from malignant mesothelioma effectively. Recently, our group applied high throughput technology to the identification of new markers that may aid in differentiating these two cancer types and validated several of these markers in follow-up studies. This review will present current data regarding the diagnostic and biological aspects of malignant mesothelioma and ovarian/peritoneal serous carcinoma.
Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway. bend@medisin.uio.no
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Davidson
D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis; D057167:Claudins / Q000032:analysis; D019927:Cyclin E / Q000032:analysis; D003581:Cytodiagnosis; D004268:DNA-Binding Proteins / Q000032:analysis; D003937:Diagnosis, Differential; D005122:Exudates and Transudates; D005260:Female; D058975:Folate Receptor 1 / Q000032:analysis; D057166:High-Throughput Screening Assays; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000032:analysis; D060588:LIM Domain Proteins; D008297:Male; D008565:Membrane Proteins; D008654:Mesothelioma / Q000175:diagnosis / Q000473:pathology; D055264:Mucin-4 / Q000032:analysis; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000175:diagnosis / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000473:pathology; D011237:Predictive Value of Tests; D019063:Tenascin / Q000032:analysis
D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D057167:Claudins; D019927:Cyclin E; D004268:DNA-Binding Proteins; C548696:FOLR1 protein, human; C548697:FOLR3 protein, human; D058975:Folate Receptor 1; D060588:LIM Domain Proteins; C088088:LIMS1 protein, human; C524658:MUC4 protein, human; D008565:Membrane Proteins; D055264:Mucin-4; D019063:Tenascin; C081865:tenascin X; D007335:Insulin-Like Growth Factor II