Ameloblastic carcinoma, secondary type: a case report.
Malignant variants of ameloblastoma include metastasizing ameloblastoma, which microscopically appears benign but has metastasized and ameloblastic carcinoma that exhibits malignant histopathologic features. Ameloblastic carcinoma is classified into 2 types: a primary odontogenic malignancy and a secondary type resulting from malignant transformation of ameloblastoma. Most secondary ameloblastic carcinomas result from malignant transformation of a primary lesion after repeated postsurgical recurrences. Therefore it is rare to find an untreated secondary type presenting with histologic features of malignant transformation from an earlier benign lesion. We experienced a rare case of ameloblastic carcinoma, secondary type which might arise in an untreated ameloblastoma. The mechanism by which a preexisting benign ameloblastoma goes through a malignant transformation is also described.
Department of Oral and Maxillofacial Surgery, Tokai University Hachioji Hospital, Tokyo, Japan. karakida@is.icc.u-tokai.ac.jp
Kazunari
K
Karakida
Takayuki
T
Aoki
Haruo
H
Sakamoto
Miho
M
Takahashi
Tadashi
T
Akamatsu
Go
G
Ogura
Yasutomo
Y
Sekido
Yoshihide
Y
Ota
D000328:Adult; D000564:Ameloblastoma / Q000473:pathology*; D001706:Biopsy; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D009808:Odontogenic Tumors / Q000473:pathology*; D011862:Radiography, Panoramic; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53