Tablets containing drug-loaded polymeric nanocapsules: an innovative platform.
The aim of the present work was to evaluate the feasibility to convert drug-loaded nanocapsule suspensions in a solid dosage form (tablets). Dexamethasone was used as a model drug due to its low aqueous solubility and fast drug release from conventional tablets. Granules containing dexamethasone-loaded nanocapsules were obtained by a wet granulation process using a dispersion of polyvinylpirrolidone/nanocapsules as a binder system. Granules were compressed in an eccentric compression machine (D-NC-T). A control formulation (tablets without nanocapsules) was also prepared (D-T). Tablets were characterized by means of mean weight, hardness, friability, diameter, thickness, disintegration time, drug content, morphological analysis by scanning electron microscopy (SEM), and in vitro drug release studies. D-NC-T showed adequate physicochemical characteristics according to the pharmacopeial requirements in terms of mean weight, hardness, friability, disintegration time and drug content. Intact nanocapsules in tablets were observed by SEM. In vitro drug release studies showed a slower release of dexamethasone from these tablets (D-NC-T) compared to the control formulation (D-T). Results showed that these tablets represent an interesting platform to the development of oral drug delivery systems containing polymeric nanocapsules.
Programa de Pós-Graduagĩo em Ciências Farmacêuticas, Departamento de Farmácia Industrial, Av. Roraima, 1000, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
R B
RB
Friedrich
M O
MO
Bastos
M C
MC
Fontana
A F
AF
Ourique
R C R
RC
Beck
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*
D053769:Nanocapsules; D011108:Polymers; D013607:Tablets; D003907:Dexamethasone; D011205:Povidone