Outcome predictors after gamma knife radiosurgery for recurrent trigeminal neuralgia.
BACKGROUND
Trigeminal neuralgia (TN) that recurs after surgery can be difficult to manage.


OBJECTIVE
To define management outcomes in patients who underwent gamma knife stereotactic radiosurgery (GKSR) after failing 1 or more previous surgical procedures.


METHODS
We retrospectively reviewed outcomes after GKSR in 193 patients with TN after failed surgery. The median patient age was 70 years (range, 26-93 years). Seventy-five patients had a single operation (microvascular decompression, n=40; glycerol rhizotomy, n=24; radiofrequency rhizotomy, n=11). One hundred eighteen patients underwent multiple operations before GKSR. Patients were evaluated up to 14 years after GKSR.


RESULTS
After GKSR, 85% of patients achieved pain relief or improvement (Barrow Neurological Institute grade I-IIIb). Pain recurrence was observed in 73 of 168 patients 6 to 144 months after GKSR (median, 6 years). Factors associated with better long-term pain relief included no relief from the surgical procedure preceding GKSR, pain in a single branch, typical TN, and a single previous failed surgical procedure. Eighteen patients (9.3%) developed new or increased trigeminal sensory dysfunction, and 1 developed deafferentation pain. Patients who developed sensory loss after GKSR had better long-term pain control (Barrow Neurological Institute grade I-IIIb: 86% at 5 years).


CONCLUSIONS
GKSR proved to be safe and moderately effective in the management of TN that recurs after surgery. Development of sensory loss may predict better long-term pain control. The best candidates for GKSR were patients with recurrence after a single failed previous operation and those with typical TN in a single trigeminal nerve distribution.
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Hideyuki
H
Kano
Douglas
D
Kondziolka
Huai-Che
HC
Yang
Oscar
O
Zorro
Javier
J
Lobato-Polo
Thomas J
TJ
Flannery
John C
JC
Flickinger
L Dade
LD
Lunsford
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019299:Decompression, Surgical / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011237:Predictive Value of Tests; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D012008:Recurrence; D012044:Regression Analysis; D012189:Retrospective Studies; D012678:Sensation Disorders / Q000175:diagnosis; D013997:Time Factors; D016896:Treatment Outcome; D014277:Trigeminal Neuralgia / Q000601:surgery*