Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology.
The association between preconception dietary intake of the polyunsaturated fatty acids (LC-PUFAs) omega-6 and omega-3 and the E(2) levels and IVF/intracytoplasmic sperm injection (ICSI) outcome were investigated in women in a prospective study. It revealed that high intakes of omega-3 LC-PUFA alpha-linolenic acid increase baseline E(2), high intakes of eicosapentaenoic acid and docosahexaenoic acid reduce E(2) response and the number of follicles after ovarian stimulation, and total omega-3 intake, in particular alpha-linolenic acid and docosahexaenoic acid, improve embryo morphology.
Department of Obstetrics and Gynecology/Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Fatima
F
Hammiche
Marijana
M
Vujkovic
Willeke
W
Wijburg
Jeanne H M
JH
de Vries
Nick S
NS
Macklon
Joop S E
JS
Laven
Régine P M
RP
Steegers-Theunissen
D000328:Adult; D048430:Cell Shape / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D019587:Dietary Supplements; D004435:Eating / Q000502:physiology; D004622:Embryo, Mammalian / Q000166:cytology* / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000178:diet therapy / Q000628:therapy; D009749:Nutrition Surveys; D016742:Preconception Care / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011786:Quality Control
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3