Elimination of active trachoma after two topical mass treatments with azithromycin 1.5% eye drops.
BACKGROUND
Following an epidemiological study carried out in 2006 showing a high prevalence of blinding trachoma in the Far North Region of Cameroon, a trachoma elimination programme using the SAFE strategy was initiated: three yearly trachoma mass treatments were to be performed.


RESULTS
The entire district population (120,000 persons) was treated with azithromycin 1.5% eye drops in February 2008 and January 2009. To assess the effect of treatment on the prevalence of active trachoma, three epidemiological studies were conducted on a representative sample of children aged between 1 and 10 years. The first study was performed just prior to the first treatment, the second just prior to the 2nd treatment and the third one, one year later. The prevalence of active forms of trachoma (TF + TI) dropped from 31.5% (95%CI 26.4-37.5) before treatment to 6.3% (95%CI 4.1-9.6) one year after first treatment; a reduction of nearly 80%. One year after the second treatment, the prevalence decreased to 3.1% (95%CI 2.0-4.9), a total reduction of 90%. Furthermore, there were no more TI cases (only TF). There was no report of serious or systemic side effects. Tolerance was excellent.


CONCLUSIONS
Active trachoma mass treatment with azithromycin 1.5% eye drops is feasible, well tolerated, and effective.
Faculté des Sciences de la Santé, Niamey, Niger.
Abdou
A
Amza
Pablo
P
Goldschmidt
Ellen
E
Einterz
Pierre
P
Huguet
Celine
C
Olmiere
Philippe
P
Bensaid
Lucienne
L
Bella-Assumpta
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D002163:Cameroon / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009883:Ophthalmic Solutions / Q000009:adverse effects / Q000627:therapeutic use*; D015995:Prevalence; D014141:Trachoma / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D017963:Azithromycin