Receptor signaling in immune cell development and function.
Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE transduces signal that promotes mast cell survival and induces mast cell activation. In dendritic cells and macrophages, the toll-like receptors recognize microbial pathogens and play critical roles for both innate and adaptive immunity against pathogens. Our research explores how signaling from these receptors is transduced and regulated to better understand these immune cells. Our recent studies have revealed diacylglycerol kinases and TSC1/2-mTOR as critical signaling molecules/regulators in T cells, mast cells, dendritic cells, and macrophages.
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. zhong001@mc.duke.edu
Xiao-Ping
XP
Zhong
Jinwook
J
Shin
Balachandra K
BK
Gorentla
Tommy
T
O'Brien
Sruti
S
Srivatsan
Li
L
Xu
Yong
Y
Chen
Danli
D
Xie
Hongjie
H
Pan
D000818:Animals; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D019852:Diacylglycerol Kinase / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology / Q000502:physiology; D007073:Immunoglobulin E / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000276:immunology / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; C000624650:TSC1 protein, human; D051193:Toll-Like Receptors; C000624651:Tsc1 protein, mouse; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins; D007073:Immunoglobulin E; C546843:mTOR protein, mouse; D019852:Diacylglycerol Kinase; D058570:TOR Serine-Threonine Kinases