[New in light of immune modulation by probiotics bacteria and increase IL10 producing regulatory T cells].
Studies on probiotics had found a benefit in their use. That was attributed to a barrier effect at the intestinal mucosa. We tried a new immunephysiological explanation supported by murine works and in humans. Immune modulation by probiotic bacteria and induce IL10 producing regulatory T cells. Receptors DCSIGN and Toll dendrites cells interfere in the copresentation of antigens and generate an immune response modulation by regulatory T cells and their inhibitory cytokines TGFβ, IL10.
Service de pneumologie et allergologie clinique, hôpital Armand-Trousseau, 26, avenue du Docteur-Arnold-Netter, 75571 Paris cedex 12, France. jeanpaul.magny@trs.aphopparis.fr
J-P
JP
Magny
D000818:Animals; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis*; D019936:Probiotics / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology*
D016753:Interleukin-10