SIRT3 in calorie restriction: can you hear me now?
Caloric restriction decreases oxidative damage and extends life span in many organisms. Someya et al. (2010) show that the sirtuin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promoting the mitochondrial antioxidant system through the regulation of isocitrate dehydrogenase 2 (Idh2).
The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, 02114, USA.
Carlos
C
Sebastian
Raul
R
Mostoslavsky