Antifungal activity of the honeybee products against Candida spp. and Trichosporon spp.
Honeybee products (honey, royal jelly, pollen, and propolis) were evaluated for their ability to inhibit the growth of 40 yeast strains of Candida albicans, Candida glabrata, Candida krusei, and Trichosporon spp. The broth microdilution method was used to assess the antifungal activity of honeybee products against yeasts. Fluconazole was selected as the antifungal control agent. Using the broth microdilution method, minimal inhibitory concentration ranges with regard to all isolates were 5-80% (vol/vol), 0.06-1 μg/mL, 0.002-0.25 μg/mL, 0.006-0.1 μg/mL, and 0.02-96 μg/mL for honey, royal jelly, pollen, propolis, and fluconazole, respectively. The antifungal activities of each product decreased in the following order: propolis >pollen > royal jelly > > honey. This study demonstrated that honeybee products, particularly propolis and pollen, can help to control some fluconazole-resistant fungal strains.
Department of Microbiology, Medical Faculty, Safiye Cikrikcioglu Vocational College, Erciyes University, Kayseri, Turkey.
Ayşe Nedret
AN
Koç
Sibel
S
Silici
Filiz
F
Kasap
Hatice Tuna
HT
Hörmet-Oz
Hikmet
H
Mavus-Buldu
Bariş Derya
BD
Ercal
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001516:Bees / Q000737:chemistry*; D002175:Candida / Q000187:drug effects*; D005227:Fatty Acids / Q000494:pharmacology*; D006722:Honey / Q000032:analysis*; D008826:Microbial Sensitivity Tests; D011429:Propolis / Q000494:pharmacology*; D014250:Trichosporon / Q000187:drug effects*; D000099219:Royal Jelly
D000935:Antifungal Agents; D005227:Fatty Acids; D011429:Propolis; D000099219:Royal Jelly