Comparison of vitreous and plasma levels of vascular endothelial growth factor, interleukin-6 and hepatocyte growth factor in diabetic and non-diabetic retinal detachment cases.
We compared the vitreous and plasma levels of proinflammatory cytokines in diabetic patients who underwent pars plana vitrectomy. Levels of proinflammatory cytokines in the vitreous were higher in the diabetic patients than the non-diabetics while the levels of plasma cytokines were similar. It is thought that this increase in the vitreous is effective in the progression of angiogenesis and the development of proliferative diabetic retinopathy.
Ophthalmology Department, Dokuz Eylul University, School of Medicine, Izmir, Turkey. nkocak@yahoo.com
Nilufer
N
Kocak
Inci
I
Alacacioglu
Suleyman
S
Kaynak
Mehmet Ali
MA
Ozcan
Olcayto
O
Celik
Faize
F
Yuksel
Ozden
O
Piskin
Hakan
H
Oner
Ali Osman
AO
Saatci
Mehmet
M
Ergin
D003930:Diabetic Retinopathy / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D014822:Vitreous Body / Q000378:metabolism*
C066855:HGF protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor