Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: data from community-based field clinics.
A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.
Pathology and Microbiology, Aga Khan University, Karachi, Pakistan.
Yasraba
Y
Rafiq
Kauser
K
Jabeen
Rumina
R
Hasan
Sana
S
Jafri
Rabia
R
Laiq
Faisal
F
Malik
Rafique
R
Mangi
Abid
A
Channa
Zahra
Z
Hasan
D000554:Ambulatory Care Facilities / Q000706:statistics & numerical data; D000995:Antitubercular Agents / Q000494:pharmacology*; D015373:Bacterial Typing Techniques; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D009841:Oligonucleotides / Q000032:analysis; D010154:Pakistan / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000382:microbiology; D014505:Urban Population
D000995:Antitubercular Agents; D024841:Fluoroquinolones; D009841:Oligonucleotides