Tripartite-motif proteins and innate immune regulation.
The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.
Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
Finlay W
FW
McNab
Ricardo
R
Rajsbaum
Jonathan P
JP
Stoye
Anne
A
O'Garra
D020816:Amino Acid Motifs; D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D011506:Proteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology
D011506:Proteins