Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density.
The purpose of this study was to investigate the expression pattern of extracellular matrix metalloproteinase inducer (EMMPRIN) as well as the correlation between EMMPRIN and microvessel density (MVD) in salivary gland tumors. Extracellular matrix metalloproteinase inducer expression and MVD were examined immunohistochemically on paraffin-embedded tissue specimens from 95 patients with salivary gland tumors, who underwent surgical resection from 1998 to 2006. Reverse transcription-polymerase chain reaction was used to monitor EMMPRIN mRNA expression in frozen samples. Extracellular matrix metalloproteinase inducer expression in mucoepidermoid carcinomas and adenoid cystic carcinomas was significantly higher than in normal salivary gland tissues and pleomorphic adenomas (P < 0.05). The MVD of mucoepidermoid carcinomas and adenoid cystic carcinomas was significantly higher compared with pleomorphic adenomas (P < 0.05). The MVD of the EMMPRIN-positive expression group was significantly higher than the MVD of the EMMPRIN-negative expression group (P < 0.05). Extracellular matrix metalloproteinase inducer mRNA expression in malignant salivary gland tumors was higher than that in pleomorphic adenomas (P < 0.05). This study suggests that EMMPRIN expression is an important feature of malignant salivary gland tumors and can be used as a biologic marker to characterize salivary gland tumors. Extracellular matrix metalloproteinase inducer is also a positive angiogenic factor in salivary gland tumors.
Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China.
Zhi-Quan
ZQ
Huang
Wei-liang
WL
Chen
Hai-Gang
HG
Li
Jin-Song
JS
Li
Zhi-Ying
ZY
Xu
Zhao-Yu
ZY
Lin
D008949:Adenoma, Pleomorphic / Q000098:blood supply / Q000276:immunology; D043925:Angiogenesis Inducing Agents / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D051926:Basigin / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D003528:Carcinoma, Adenoid Cystic / Q000098:blood supply / Q000276:immunology; D018277:Carcinoma, Mucoepidermoid / Q000098:blood supply / Q000276:immunology; D004848:Epithelium / Q000098:blood supply / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D055806:Microvessels / Q000473:pathology*; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018987:Salivary Ducts / Q000098:blood supply / Q000276:immunology; D012468:Salivary Gland Neoplasms / Q000098:blood supply / Q000276:immunology*; D012469:Salivary Glands / Q000098:blood supply / Q000276:immunology
D043925:Angiogenesis Inducing Agents; D018952:Antigens, CD34; D000951:Antigens, Neoplasm; C497886:BSG protein, human; D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D051926:Basigin