[Calcitonin--contra-insulin hormone].
The review contains literature data about calcitonin's participation in the glucose metabolism. The analyses of retrospective and current sources of information about contra-insulin effect of calcitonin on the glucose metabolism has been revealed. Some arguments of antagonistic calcitonin effect to insulin under the pre-receptor, cell level and liver were done. The impairment of glucose metabolism under calcitonin is established--hyperglycemia, insulin resistance and glucose intolerance. A calcitonin diabetogenic effect and its role as a "risk factor" in the development of metabolic syndrome and diabetic mellitus are discussed.
S S
SS
Butakova
A D
AD
Nozdrachev
D000818:Animals; D002116:Calcitonin / Q000378:metabolism / Q000502:physiology*; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism
D007328:Insulin; D002116:Calcitonin; D005947:Glucose