Transmission of varicella vaccine virus to a non-family member in China.
A 23-year-old teacher presented to hospital with a mild case of varicella. VZV vaccine strain vOka that resembles Varilrix but not Varivax or Biken strains was isolated from the skin lesion of the patient and was identified by single nucleotide polymorphism (SNP) analysis. The teacher denied having varicella vaccine before. Retrospective analysis suggests the transmission came from a pupil who developed zoster 13 months after varicella vaccine Varilrix. This is the first report in China in which an adult with varicella was attributable to vaccine virus and the 6th report of transmission of vaccine virus to a susceptible adult around the world.
Department of Microbiology, Anhui Medical University, Hefei, 230032, China.
Lin
L
Gan
Mingli
M
Wang
Sen
S
Yang
Anne A
AA
Gershon
Jason J
JJ
Chen
D002644:Chickenpox / Q000635:transmission*; D019433:Chickenpox Vaccine / Q000009:adverse effects; D002681:China; D005260:Female; D014645:Herpesvirus 3, Human / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
D019433:Chickenpox Vaccine