DNA tunneling detector embedded in a nanopore.
We report on the fabrication and characterization of a DNA nanopore detector with integrated tunneling electrodes. Functional tunneling devices were identified by tunneling spectroscopy in different solvents and then used in proof-of-principle experiments demonstrating, for the first time, concurrent tunneling detection and ionic current detection of DNA molecules in a nanopore platform. This is an important step toward ultrafast DNA sequencing by tunneling.
Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Aleksandar P
AP
Ivanov
Emanuele
E
Instuli
Catriona M
CM
McGilvery
Geoff
G
Baldwin
David W
DW
McComb
Tim
T
Albrecht
Joshua B
JB
Edel
D004247:DNA / Q000032:analysis*; D004563:Electrochemistry / Q000295:instrumentation; D004566:Electrodes; D004867:Equipment Design; D058608:Nanopores / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation*; D013057:Spectrum Analysis / Q000295:instrumentation
D004247:DNA