Long-term effects of the extended wear of senofilcon A silicone hydrogel contact lenses on ocular tissues.
OBJECTIVE
The objective of the investigation was to show that, because of their overall properties, Acuvue® Oasys™ with Hydraclear™ Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term extended wear.


METHODS
The investigation was a 2-year, prospective, extended wear investigation of senofilcon A silicone hydrogel contact lenses worn for up to 6 nights without removal.


RESULTS
The 2-year results compared with the subjects' baseline ocular statuses on entering the study revealed:


CONCLUSIONS
The quantification of the effects on the ocular tissues of 2 years of extended wear of senofilcon A, by mainly previously successful daily soft contact lens wearers, found an excellent biocompatibility. The results support the hypothesis that senofilcon A contact lenses, when worn on a 6-night/7-day extended wear regimen, maintain excellent long-term ocular tissue tolerance.
OTG Research & Consultancy, 66 Buckingham Gate, London, England. mguillon@otg.co.uk
Michel
M
Guillon
Cécile
C
Maïssa
D000293:Adolescent; D000328:Adult; D003228:Conjunctiva / Q000098:blood supply; D003229:Conjunctival Diseases / Q000209:etiology / Q000517:prevention & control*; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects*; D003316:Corneal Diseases / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D020100:Hydrogels; D006940:Hyperemia / Q000209:etiology / Q000517:prevention & control*; D016850:Limbus Corneae / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012828:Silicones; D006113:United Kingdom
D020100:Hydrogels; D012828:Silicones; C523196:senofilcon A