Current concepts regarding the HTLV-1 receptor complex.
The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection.
CNRS UMR8147, Universite Rene Descartes, Paris 5, 161 Rue de Sèvres, 75743 Paris Cedex 15, France. david.ghez@igr.fr
David
D
Ghez
Yves
Y
Lepelletier
Kathryn S
KS
Jones
Claudine
C
Pique
Olivier
O
Hermine
D051272:Glucose Transporter Type 1 / Q000502:physiology; D015490:HTLV-I Infections / Q000821:virology*; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D039942:Neuropilin-1 / Q000502:physiology; D011991:Receptors, Virus / Q000378:metabolism*; D053585:Virus Attachment
D051272:Glucose Transporter Type 1; D019812:Heparan Sulfate Proteoglycans; D011991:Receptors, Virus; D039942:Neuropilin-1