Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets.
The present study is aimed to develop dextromethorphan hydrobromide (DXM) oral disintegrating tablets (ODT) with acceptable palatability to help patients of all age groups. The bitter taste of the drug was masked by binding the drug to ion exchange resin. The effect of the particle size of resin on drug loading was studied. In vitro and in vivo disintegration time and in vitro drug release studies were performed. Drug loading increased significantly with a decrease in the particle size of the resin. DSC and XRPD studies reveal that the molecular state of the drug changed from crystalline to amorphous form. The dissolution efficiency calculated for optimized ODT and conventional directly compressed tablet were almost comparable, indicating free dissociation of the drug from the resinate. The bitter taste of DXM can be masked by binding with ion exchange resin and the resinate can be successfully formulated into oral disintegrating tablets.
CPS Formulations, DR. Reddy's Laboratories Limited, Bachupally, Hyderabad-500090, India.
Madhusudhan
M
Malladi
Raju
R
Jukanti
Rashmi
R
Nair
Sanjay
S
Wagh
Hari Shanker
HS
Padakanti
Ashok
A
Mateti
D000284:Administration, Oral; D000996:Antitussive Agents / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003915:Dextromethorphan / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D007475:Ion Exchange Resins / Q000737:chemistry*; D008297:Male; D010316:Particle Size; D012995:Solubility; D013607:Tablets; D013649:Taste; D014961:X-Ray Diffraction
D000996:Antitussive Agents; D007475:Ion Exchange Resins; D013607:Tablets; D003915:Dextromethorphan