Antibacterial sphingolipid and steroids from the black coral Antipathes dichotoma.
From the black coral Antipathies dichotoma, a sphingolipid (2S*,3S*,4E,8E)-2N-[tetradecanoyl]-4(E),8(E)-icosadiene-1,3-diol (1) and a steroid (22E)-methylcholesta-5,22-diene-1α,3β,7α-triol (2) were isolated. Other known compounds, 3β,7α-dihydroxy-cholest-5-ene (3), (22E,24S),5α,8α-epidioxy-24-methylcholesta-6,22-dien-3β-ol (4) and (22E,24S),5α,8α-epidioxy-24-methylcholesta-6,9(11),22-trien-3β-ol (5). The structures were established on the basis of NMR spectroscopic analysis and comparison with literature. The antibacterial activity of five compounds was evaluated.
Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, Saudi Arabia.
Sultan Samran
SS
Al-Lihaibi
Seif-Eldin Nasr
SE
Ayyad
Fekry
F
Shaher
Walied Mohamed
WM
Alarif
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003684:Dehydrocholesterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D013107:Sphingolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C556722:(22E)-methylcholesta-5,22-diene-1alpha,3beta,7alpha-triol; C556723:2N-(tetradecanoyl)-4(E),8(E)-icosadiene-1,3-diol; D000900:Anti-Bacterial Agents; D003684:Dehydrocholesterols; D013107:Sphingolipids; D013256:Steroids