Lipoprotein(a) and the risk of thromboembolism in Thai children.
High lipoprotein(a) [Lp(a)] level was identified as a risk factor of both venous and arterial thromboembolism (TE), especially in Caucasian children. The Lp(a) level is affected by apo(a) gene. The genetic polymorphisms that associated with Lp(a) level are the size of apo(a) gene, pentanucleotide repeat (TTTTA)(n) and +93C/T at promoter region. The increasing size of apo(a) gene, more than 8 pentanucleotide repeats and +93C>T polymorphisms are associated with low level of Lp(a) in African and Caucasian populations. This cross - sectional, case control study, aims to identify the association of Lp(a) level and the risk for TE in Thai children. Forty-nine patients and 116 healthy children were enrolled. Mean ± SD for age of patients and controls were 7.6 ± 4.7 and 11.2 ± 1.7 years, with female:male ratios of 1:1.2 and 1.8:1, respectively. The median Lp(a) levels in patients was 8.2 (0-87.3) mg/dL and 7.9 (0-74.9) mg/dL in controls, which were not statistically different, P=0.65. The frequencies of 8 pentanucleotide repeats and +93C/T were different compared to Caucasian and African populations but similar to Chinese population. However, both polymorphisms did not affect the level of Lp(a).
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. rasrb@mahidol.ac.th
Nongnuch
N
Sirachainan
Chalermkwan
C
Chaiyong
Anannit
A
Visudtibhan
Werasak
W
Sasanakul
Seksit
S
Osatakul
Pakawan
P
Wongwerawattanakoon
Praguywan
P
Kadegasem
Ampaiwan
A
Chuansumrit
D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013785:Thailand; D013923:Thromboembolism / Q000097:blood / Q000175:diagnosis / Q000235:genetics*
D017270:Lipoprotein(a)