LXR-α selectively reprogrammes cancer cells to enter into apoptosis.
There exists a general recognition of the fact that LXR-α, being a member of the nuclear receptor family, plays a crucial role in the biological process that connects inflammation, cholesterol homeostasis, and cellular decisions. In this context the present study was addressed to understand the role of LXR-α gene in the selective and specific reprogramming of cancer cells into a state of apoptosis leaving the normal cells unaffected. The results of this study revealed that LXR-α gene when activated in cancerous cells of diverse origin results in the regulation of genes coding for Bcl-2, AATF, and Par-4 in a fashion, forcing these cells to enter into the state of apoptosis leaving the normal cells unaffected. On the basis of this study we propose that in near future LXR-α agonist (Withaferin A) may definitely find its use in the therapeutic interventions directed towards the treatment of cancer.
Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Aanchal
A
Mehrotra
Deepak
D
Kaul
Kusum
K
Joshi
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D050687:E2F1 Transcription Factor / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D017930:Genes, Reporter; D006801:Humans; D006888:Hydroxycholesterols / Q000494:pharmacology; D008024:Ligands; D000071518:Liver X Receptors; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D057093:Orphan Nuclear Receptors / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D034622:RNA Interference; D020218:Response Elements; D015398:Signal Transduction; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D013601:T-Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D014158:Transcription, Genetic / Q000187:drug effects; D025521:Tumor Suppressor Proteins / Q000235:genetics; D054358:Withanolides / Q000494:pharmacology
D000970:Antineoplastic Agents; D051792:Basic Helix-Loop-Helix Proteins; D050687:E2F1 Transcription Factor; D006888:Hydroxycholesterols; D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D051780:Sterol Regulatory Element Binding Protein 1; D025521:Tumor Suppressor Proteins; D054358:Withanolides; C493753:E2F1 protein, human; C079440:MXI1 protein, human; C000605213:NR1H3 protein, human; C009684:withaferin A