Fundic gland polyps and association with proton pump inhibitor intake: a prospective study in 1,780 endoscopies.
OBJECTIVE
Fundic gland polyps (FGPs) are incidentally found when an endoscopy is performed for a non-related indication. Some authors suggested a relationship with proton pump inhibitor (PPI) intake. We aimed to determine their prevalence and association with PPI intake.


METHODS
We prospectively studied 1,780 patients who underwent a gastroduodenal endoscopy at our ambulatory care center between June 2007 and August 2008. PPI intake during a period of at least 12 months, female gender and age were statistically evaluated as risk factors for the presence of FGPs. Then, a multiple logistic regression analysis was applied to these variables.


RESULTS
Gastric polyps were found in 129 patients (7.2%) and 77 (4.33%) were FGPs. Five patients with no available histology were excluded for the assessment of risk factors. PPI intake was detected in 49 patients with FGPs (63.6%) and 264 without FGPs (15.5%) (P < 0.0001). Fifty-nine patients with FGPs (76.7%) and 987 without FGPs (58.1%) were women (P < 0.001). The mean age was 58.91 ± 11.82 years in patients with FGPs and 50.34 ± 15.04 years in patients without FGPs (P < 0.0001). The three variables remained significant in the multiple model: PPI intake: P < 0.0001, OR 9.00 (95% CI 5.44-14.89); female gender: P = 0.0001, OR 2.95 (95% CI 1.69-5.15); age: P = 0.001, OR 1.03 (95% CI 1.01-1.05).


CONCLUSIONS
In our population, the prevalence of FGPs was high. Although female gender and age were also significant, PPI intake was the strongest risk factor associated with the presence of FGPs.
Centro Integral de Gastroenterología, Ecuador 1481, Buenos Aires C1425EUG, Argentina.
Adriana
A
Zelter
José Luis
JL
Fernández
Claudio
C
Bilder
Pablo
P
Rodríguez
Andrés
A
Wonaga
Fernanda
F
Dorado
Miriam
M
Galich
Luis Alberto
LA
Viola
D000328:Adult; D005260:Female; D005773:Gastroscopy; D006801:Humans; D016017:Odds Ratio; D011127:Polyps / Q000209:etiology*; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D012307:Risk Factors; D013272:Stomach Diseases / Q000209:etiology* / Q000473:pathology
D054328:Proton Pump Inhibitors