CpG oligodeoxynucleotides protect against the 2009 H1N1 pandemic influenza virus infection in a murine model.
The 2009 H1N1 influenza virus pandemic poses a global public health threat, and there is a critical need for antiviral drugs for pandemic control. CpG oligodeoxynucleotides have strong immunostimulatory properties and are expected to be used as prophylactic agents to protect against microbial infections. The present study evaluated the efficacy of synthetic CpG oligodeoxynucleotide (ODN) 1826 against pandemic H1N1 virus infection in a murine model. A single injection of 15 μg ODN 1826 intraperitoneally prior to virus challenge inhibits virus replication in lungs, reduces lung lesions and prevents mortality in mice, indicating CpG ODNs as a possible strategy for future influenza pandemics control.
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Tao
T
Jiang
Hui
H
Zhao
Xiao-Feng
XF
Li
Yong-Qiang
YQ
Deng
Juan
J
Liu
Li-Juan
LJ
Xu
Jian-Feng
JF
Han
Rui-Yuan
RY
Cao
E-De
ED
Qin
Cheng-Feng
CF
Qin
D000818:Animals; D004195:Disease Models, Animal; D007155:Immunologic Factors / Q000008:administration & dosage*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000472:pathogenicity*; D008168:Lung / Q000473:pathology / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009838:Oligodeoxyribonucleotides / Q000008:administration & dosage*; D009976:Orthomyxoviridae Infections / Q000401:mortality / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D016019:Survival Analysis; D019562:Viral Load
C408982:CPG-oligonucleotide; D007155:Immunologic Factors; D009838:Oligodeoxyribonucleotides