Cognitive fatigue defined in the context of attention networks.
We examined the effect of cognitive fatigue on the Attention Networks Test (ANT). Participants were 228 non-demented older adults. Cognitive fatigue was operationally defined as decline in alerting, orienting, and executive attention performance over the course of the ANT. Anchored in a theoretical model implicating the frontal basal ganglia circuitry as the core substrate of fatigue, we hypothesized that cognitive fatigue would be observed only in executive attention. Consistent with our prediction, significant cognitive fatigue effect was observed in executive attention but not in alerting or orienting. In contrast, orienting improved over the course of the ANT and alerting showed a trend, though insignificant, that was consistent with learning. Cognitive fatigue is conceptualized as an executive failure to maintain and optimize performance over acute but sustained cognitive effort resulting in performance that is lower and more variable than the individual's optimal ability.
Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. roee.holtzer@einstein.yu.edu
Roee
R
Holtzer
Melissa
M
Shuman
Jeannette R
JR
Mahoney
Richard
R
Lipton
Joe
J
Verghese
D000368:Aged; D000369:Aged, 80 and over; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology; D005221:Fatigue; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012720:Severity of Illness Index