[Clinical-pharmacoeconomical aspects of ß-adrenoblockers use in patients with ischemic heart disease undergoing coronary artery bypass grafting].
Aim of this study was to assess clinical and pharmacoeconomic effects of long term use of adrenoblockers in patients with ischemic heart disease (IHD) undergoing coronary artery bypass grafting. Patients with IHD (n=294) were included in open, prospective, randomized clinical trial. The follow up period was 3 years. It was noted that long term use of bisoprolol in comparison with atenolol and metoprolol was characterized by more pronounced increase of exercise tolerance, lower rate of angina recurrence and lower expenses for treatment of patients with IHD.
Iu M
IuM
Lopatin
E P
EP
Dronova
D058671:Adrenergic beta-1 Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000787:Angina Pectoris / Q000175:diagnosis / Q000191:economics / Q000503:physiopathology / Q000628:therapy*; D001262:Atenolol / Q000008:administration & dosage / Q000009:adverse effects; D017298:Bisoprolol / Q000008:administration & dosage / Q000009:adverse effects; D057186:Comparative Effectiveness Research; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000379:methods*; D017046:Cost Savings; D005080:Exercise Test / Q000187:drug effects*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D010359:Patient Readmission; D013995:Time; D016896:Treatment Outcome
D058671:Adrenergic beta-1 Receptor Antagonists; D001262:Atenolol; D008790:Metoprolol; D017298:Bisoprolol