Clinical applications of mesenchymal stem cells in soft tissue augmentation.
Based on a variety of preclinical studies showing that mesenchymal stem cells (MSC) play a significant role in tissue repair and homeostasis, MSC have rapidly moved into a phase of clinical trials investigating their efficacy as a cell-based therapeutic modality for a diverse group of applications. An emerging body of evidence shows that in addition to being a progenitor cell population with self-renewing and multipotent differentiation capabilities, MSC have unique immunomodulatory properties, making them even more attractive for regenerative medicine. Emerging discoveries in stem cell biology have revealed a multitude of mechanisms through which MSC could potentially augment the current techniques in aesthetic surgery. In this article, the authors review the clinical advances in cell-based therapies relevant to aesthetic surgery, including tissue augmentation, rejuvenation, and regeneration.
Division of Plastic and Reconstructive Surgery, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA. shanson2@uwhealth.org
Summer E
SE
Hanson
Karol A
KA
Gutowski
Peiman
P
Hematti
D000273:Adipose Tissue / Q000637:transplantation*; D004954:Esthetics; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology; D019651:Plastic Surgery Procedures; D044968:Regenerative Medicine; D012060:Rejuvenation; D014945:Wound Healing