Leukocytes in mammary development and cancer.
Leukocytes, of both the innate and adaptive lineages, are normal cellular components of all tissues. These important cells not only are critical for regulating normal tissue homeostasis, but also are significant paracrine regulators of all physiologic and pathologic tissue repair processes. This article summarizes recent insights regarding the trophic roles of leukocytes at each stage of mammary gland development and during cancer development, with a focus on Murids and humans.
Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 94143, USA.
Lisa M
LM
Coussens
Jeffrey W
JW
Pollard
D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology*; D003094:Collagen / Q000378:metabolism; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology*; D007774:Lactation / Q000502:physiology*; D007962:Leukocytes / Q000276:immunology / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D042361:Mammary Glands, Human / Q000166:cytology* / Q000254:growth & development* / Q000276:immunology; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D022423:Myeloid Cells / Q000276:immunology; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology
D003094:Collagen