Asymmetric copper-catalysed intramolecular C-H insertion reactions of α-diazo-β-keto sulfones.
Asymmetric copper-catalysed intramolecular C-H insertion reactions of a series of α-diazo-β-keto sulfones are reported. Enantioselectivities of up to 82% ee were achieved in moderate to good yield. These results represent the highest level of enantiocontrol achieved to date for a copper-catalysed cyclopentanone synthesis via C-H insertion.
Department of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, Ireland.
Catherine N
CN
Slattery
Anita R
AR
Maguire
D001391:Azo Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
D001391:Azo Compounds; D008024:Ligands; D013450:Sulfones; D002244:Carbon; D003300:Copper; D006859:Hydrogen