Polyarteritis nodosa in a patient with type 1 autoimmune hepatitis.
Polyarteritis nodosa is a systemic necrotizing vasculitis that affects small- and medium-sized arteries. Liver involvement in patients with polyarteritis nodosa has been described, and ranges from asymptomatic elevation of aminotransferases to hepatic aneurysm rupture. We describe the case of a patient with type 1 autoimmune hepatitis and compensated liver cirrhosis who developed classic polyarteritis nodosa, complicated with cytomegalovirus and repeated urinary tract infections. After a long bedridden hospitalization, the patient's condition was stabilized. She is currently in good health, with well-controlled blood pressure, and stable kidney and liver function. To our knowledge, this is the first case report in the literature with concurrent appearance of both diseases.
Division of Gastroenterology and Hepatology and Rheumatology, 2nd Propedeutic Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Olga
O
Giouleme
Alexander
A
Mpoumponaris
Spiridon
S
Aslanidis
Panagiotis
P
Anagnostis
Panagiotis
P
Giamalis
Nikolaos
N
Nikolaidis
Themistoklis
T
Vasiliadis
Nikolaos
N
Evgenidis
D000974:Antibodies, Antinuclear / Q000276:immunology*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D018810:Magnetic Resonance Angiography; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000175:diagnosis / Q000276:immunology
D000974:Antibodies, Antinuclear