Recent advance in heterocyclic organozinc and organomanganese compounds; direct synthetic routes and application in organic synthesis.
A practical synthetic route for the preparation of 2-pyridyl and 3-pyridyl derivatives has been accomplished by utilizing a simple coupling reaction of stable 2-pyridylzinc bromides and 3-pyridylzinc bromides. The organozincs used in this study were easily prepared via the direct insertion of active zinc into the corresponding bromopyridines. The subsequent coupling reactions with a variety of different electrophiles have afforded the corresponding coupling products. Using highly active manganese, a variety of Grignard-type organomanganese reagents have been obtained. The subsequent coupling reactions of the resulting organomanganese reagents with several electrophiles have also been accomplished under mild conditions.
Department of Chemistry, Dankook University, 29 Anseo Cheonan Chungnam, 330-714, Korea. kimsemail@dankook.ac.kr
Seung-Hoi
SH
Kim
Reuben D
RD
Rieke
D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017895:Manganese Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D017967:Zinc Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D006571:Heterocyclic Compounds; D017895:Manganese Compounds; D017967:Zinc Compounds