Neuro-oncology: Genetic variation in pediatric and adult brain tumors.
Two new studies suggest that pediatric medulloblastomas and high-grade gliomas are genetically different from the same tumors in adults. Age-dependent gene expression might affect tumor biology; therefore, therapies for adult medulloblastomas or gliomas might not produce the same clinical outcomes in pediatric patients, and vice versa.
Department of Medical Oncology, Bellaria Hospital, Via Altura 3, Bologna, Italy. alba.brandes@yahoo.it
Alba A
AA
Brandes
Enrico
E
Franceschi
D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics*; D002528:Cerebellar Neoplasms / Q000235:genetics*; D002648:Child; D020869:Gene Expression Profiling; D014644:Genetic Variation; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics*