Rapid magnetic resonance-guided near-infrared mapping to image pulsatile hemoglobin in the breast.
A near-IR (NIR) tomography system with spectral-encoded sources was built to quantify the temporal contrast in human breast tissue using guidance from magnetic resonance imaging. The systems were integrated with a custom breast coil interface to provide simultaneous acquisition. The NIR signal was synchronized to simultaneous finger pulse oximeter plethysmogram, which offered a frequency reference. A 0.1 s temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue.
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA. zhiqiu.li@dartmouth.edu
Zhiqiu
Z
Li
Venkataramanan
V
Krishnaswamy
Shudong
S
Jiang
Scott C
SC
Davis
Subhadra
S
Srinivasan
Keith D
KD
Paulsen
Brian W
BW
Pogue
D001940:Breast / Q000378:metabolism*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D013997:Time Factors
D006454:Hemoglobins