Basic science review on adipose tissue for clinicians.
The recognition that fat contains stem cells has driven further examination into the potential uses of fat and adipose-derived stem cells in a wide number of clinical situations. New information about the harvesting, isolation, and subsequent differentiation properties of isolated adipose-derived stem cells has led to new research into novel tissue-engineered constructs and the transformation of adipose-derived stem cells to induced pluripotent stem cells. Clinically, use of fat grafts and adipose-derived stem cells worldwide and in the United States has dramatically increased in parallel to questions concerning the safety and efficacy of adipose-derived stem cell-based treatments. Currently, the U.S. Food and Drug Administration has not approved the use of isolated adipose-derived stem cells for medical indications.
Dallas, Texas; and Stanford, Calif. From the Department of Plastic Surgery, University of Texas Southwestern Medical Center, and the Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine.
Spencer A
SA
Brown
Benjamin
B
Levi
Charlotte
C
Lequex
Victor W
VW
Wong
Ali
A
Mojallal
Michael T
MT
Longaker
D000273:Adipose Tissue / Q000166:cytology* / Q000637:transplantation*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D039902:Multipotent Stem Cells / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering; D016896:Treatment Outcome; D014481:United States; D014486:United States Food and Drug Administration