Oxime decorated cavitands functionalized through solvent-assisted grinding.
In order to assemble supramolecular capsules, there is a need for reliable and effective synthetic methods for decorating cavitand-based host structures with appropriate functional groups. The synthesis of four different cavitands of significantly different depth and interior volume functionalized with four aldoxime groups capable of forming homomeric or heteromeric capsules through hydrogen bonding is reported. The final step in each synthesis, the aldehyde to oxime transformation, has been achieved in excellent yields through 'solvent assisted grinding'.
Department of Chemistry, Kansas State University, Manhattan, Kansas 66503, United States. aakeroy@ksu.edu
Christer B
CB
Aakeröy
Prashant D
PD
Chopade