Regulation of adaptive immunity by the NLRP3 inflammasome.
It is well known that the innate immune system can induce and regulate the development of adaptive immunity. The NLRP3 inflammasome is a multiprotein complex that controls the caspase-1 activation step that is a pre-requisite for the maturation of interleukin (IL)-1β and IL-18. Recent findings showed that the NLRP3 inflammasome not only is an innate responder to pathogenic and danger signals, but also can affect the adaptive immune response. Here we review the role of NLRP3 inflammasome in regulating adaptive immunity.
Unit of Innate Immunity, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Mingkuan
M
Chen
Hongbin
H
Wang
Wei
W
Chen
Guangxun
G
Meng
D056704:Adaptive Immunity; D000276:Adjuvants, Immunologic; D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D002450:Cell Communication; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology*; D046912:Multiprotein Complexes / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D058408:Th1-Th2 Balance
D000276:Adjuvants, Immunologic; D002352:Carrier Proteins; D058847:Inflammasomes; D046912:Multiprotein Complexes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human