Chemical constituents and antitubercular activity of Formosan Pisonia umbellifera.
Bioassay-guided fractionation of the methanolic extract of the stem of Pisonia umbellifera (Nyctaginaceae) afforded the three new compounds, secopisonic acid (1), 6,8-dimethylisogenistein (2), and (+)- ENT-ficusol (3), and four first isolates from nature, pisoninol I (4), pisoninol II (5), pisoquinoline (6), and pisodienone (7), together with fifteen known compounds. Their structures were elucidated by analysis of spectroscopic data. Seven of these isolates, 3, 7, 12, 16, 18, 20, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37R (V) in vitro, with MIC values ≤ 50 µg/mL.
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, RO C.
Hsiou-Ting
HT
Kuo
Chien-Fang
CF
Peng
Hung-Yi
HY
Huang
Chu-Hung
CH
Lin
Ih-Sheng
IS
Chen
Ian-Lih
IL
Tsai
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D039281:Nyctaginaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013624:Taiwan; D014197:Trees / Q000737:chemistry*
D000995:Antitubercular Agents; D010936:Plant Extracts