Mechanisms of metal-induced centrosome amplification.
Exposure to toxic and carcinogenic metals is widespread; however, their mechanisms of action remain largely unknown. One potential mechanism for metal-induced carcinogenicity and toxicity is centrosome amplification. Here we review the mechanisms for metal-induced centrosome amplification, including arsenic, chromium, mercury and nano-titanium dioxide.
Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, 96 Falmouth Street, Portland, ME 04104, USA.
Amie L
AL
Holmes
John Pierce
JP
Wise
D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity; D002460:Cell Line; D018385:Centrosome / Q000187:drug effects* / Q000378:metabolism*; D002857:Chromium / Q000633:toxicity*; D004781:Environmental Exposure; D006801:Humans; D008628:Mercury / Q000633:toxicity*; D049329:Nanostructures / Q000633:toxicity; D014025:Titanium / Q000737:chemistry / Q000633:toxicity*
D002273:Carcinogens; D002857:Chromium; C009495:titanium dioxide; D014025:Titanium; D008628:Mercury; D001151:Arsenic