Regulation of inflammatory and antiviral signaling by A20.
The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.
Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA.
Kislay
K
Parvatiyar
Edward W
EW
Harhaj
D000818:Animals; D016923:Cell Death; D004268:DNA-Binding Proteins; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000821:virology; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D009687:Nuclear Proteins / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; D014777:Virus Diseases / Q000276:immunology*
D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3