Structural changes in the brain of mice infected with influenza A/H5N1 virus.
Structural changes in the brain of outbred mice were studied after infection with influenza A/H5N1 strain isolated in the Novosibirsk region. High mortality was observed after intranasal infection. Examination of brain specimens revealed vasculopathies with thrombosis of the microcirculatory vessels, pericellular and perivascular edema with multifocal ischemic necrosis, hyperplasia of glial cells, caspase-dependent apoptosis of neurons caused by the cytopathic effect of the virus, and hypercytokinemia.
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. potapova@soramn.ru
O V
OV
Potapova
V A
VA
Shkurupy
T V
TV
Sharkova
A M
AM
Shestopalov
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000821:virology*; D016207:Cytokines / Q000097:blood; D053124:Influenza A Virus, H5N1 Subtype / Q000502:physiology*; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000473:pathology*
D016207:Cytokines