Processes of homeostatic proliferation in the pathogenesis of autoimmune glomerulonephritis induced by chronic graft-versus-host reaction.
Lymphopenia developing at the early stage of chronic graft-versus-host reaction is associated with increased content of IL-7 in the peripheral blood and leads to an increase of the CD4(+)and CD8(+)cell subpopulations in the spleen of the recipient. After 3 months, some animals develop autoimmune glomerulonephritis (lupus recipients). High levels of IL-7 and T-cells with the memory cell phenotype (CD4(+)CD45RB(low)and CD8(+)CD45RB(low)) persist in these animals, in contrast to nonlupus recipients without signs of autoimmune disease. This can attest to the involvement of homeostatic proliferation processes in the formation of autoimmune disease in this model.
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. L.Goiman@mail.ru
E V
EV
Goiman
O T
OT
Kudaeva
N A
NA
Ilyina
V I
VI
Borisov
V S
VS
Kozhevnikov
O P
OP
Kolesnikova
V A
VA
Kozlov
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000503:physiopathology*; D049109:Cell Proliferation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D005921:Glomerulonephritis / Q000209:etiology / Q000503:physiopathology*; D006086:Graft vs Host Disease / Q000150:complications*; D007156:Immunologic Memory / Q000276:immunology; D015851:Interleukin-7 / Q000097:blood; D051379:Mice; D008811:Mice, Inbred DBA; D013154:Spleen / Q000166:cytology / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015851:Interleukin-7