Long-term antibody persistence and immune memory to hepatitis B virus in adult celiac patients vaccinated as adolescents.
Aim of this study was to investigate the anti-HBs antibody persistence and immune memory to hepatitis B virus in adult celiacs vaccinated as adolescents and the effect of a booster administration in non-protected individuals. Eleven years after primary vaccination, the proportion of vaccinees with titres ≥ 10 mIU/ml and antibody geometric mean concentrations (GMCs) were lower among celiac patients than among controls (68.6% vs 91.7%, p<0.01; GMCs 29.38 mIU/ml vs 250.6 mIU/ml, p<0.001). Participants with anti-HBs below 10 mIU/ml received a booster dose and were retested 2 weeks later to assess the anamnestic response. Post-booster anti-HBs levels were still <10 mIU/ml in 71.4% celiacs and 25% controls (p<0.01). Our findings indicate that the prevalence of seroprotective levels of anti-HBs detected eleven years after primary immunization as well as the frequency of response to a booster dose of vaccine are lower in celiac patients compared to healthy controls.
Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy.
F
F
Zingone
F
F
Morisco
A
A
Zanetti
L
L
Romanò
G
G
Portella
P
P
Capone
P
P
Andreozzi
R
R
Tortora
C
C
Ciacci
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002446:Celiac Disease / Q000276:immunology*; D002648:Child; D005260:Female; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods; D008297:Male; D013997:Time Factors
D000914:Antibodies, Viral; D017325:Hepatitis B Vaccines