Suicide attempt in ulcerative colitis patient after 4 months of infliximab therapy--a case report.
In the summary of product characteristics of infliximab (IFX), psychiatric side effects are reported to be rare, and in literature only limited data exist. This report presents a case of a patient with ulcerative colitis who developed a depression with psychotic symptoms during IFX therapy and made a suicide attempt 4 months after the initiation of therapy. Although the time between start of IFX therapy and onset of symptoms could suggest a correlation, this, of course, does not prove that IFX was the causative factor for his depression and suicide attempt.
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
E J
EJ
Eshuis
K M M Y
KM
Magnin
P C F
PC
Stokkers
W A
WA
Bemelman
J
J
Bartelsman
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000523:psychology*; D003866:Depressive Disorder / Q000139:chemically induced*; D006801:Humans; D000069285:Infliximab; D008297:Male; D013406:Suicide, Attempted
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab