Effects of fenoldopam mesylate infusion on splanchnic perfusion after myocardial revascularization on cardiopulmonary bypass: an ultrasound Doppler study.
OBJECTIVE
To measure the effects of fenoldopam mesylate infusion on splanchnic blood flow in patients undergoing myocardial revascularization with cardiopulmonary bypass.


METHODS
An experimental observational study.


METHODS
A single-institution community hospital.


METHODS
Eighteen patients undergoing on-pump coronary artery bypass graft surgery.


METHODS
Fenoldopam mesylate infusion (0.1 μg/kg/min).


RESULTS
Blood flow through the celiac artery, superior mesenteric artery, portal vein and hepatic artery were assessed by means of Doppler measurements. The main hemodynamic variables were measured using echocardiography. The infusion of fenoldopam significantly increased the blood flow through both celiac and superior mesenteric arteries by decreasing vascular resistance. The percentage of cardiac output directed to these 2 vessels increased significantly; the increase through the superior mesenteric artery was greater compared with the celiac artery. Portal vein and hepatic artery blood flow also consistently increased. No significant variations were observed with respect to hemodynamic variables.


CONCLUSIONS
The infusion of fenoldopam increased the flow through the celiac artery and superior mesenteric artery; the effect was higher for the latter. These changes did not affect the hemodynamic variables.
Department of Cardiac Surgery, Anesthesia and Intensive Care, Sant'Ambrogio Hospital, Milan, Italy. massimo.meco@virgilio.it
Massimo
M
Meco
Marie Claire
MC
Allaz
Silvia
S
Cirri
D000368:Aged; D002315:Cardiopulmonary Bypass; D002445:Celiac Artery / Q000187:drug effects / Q000502:physiology; D001026:Coronary Artery Bypass; D018491:Dopamine Agonists / Q000494:pharmacology*; D005260:Female; D018818:Fenoldopam / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D017538:Mesenteric Artery, Superior / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D013152:Splanchnic Circulation / Q000187:drug effects; D018608:Ultrasonography, Doppler / Q000379:methods*
D018491:Dopamine Agonists; D018818:Fenoldopam