Lobophytones H-N, Biscembranoids from the Chinese soft coral Lobophytum pauciflorum.
Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of seven new biscembranoids, named lobophytones H-N (1-7). Their structures were determined by interpretation of 1D- and 2D-NMR (correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), and nuclear Overhauser effect spectroscopy (NOESY)) spectroscopic data in association with MS and IR data. All compounds were tested for the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production, cytotoxicity of mouse peritoneal macrophage, and antibacterial activities.
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, China.
Pengcheng
P
Yan
Zhiwei
Z
Deng
Leen
L
van Ofwegen
Peter
P
Proksch
Wenhan
W
Lin
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D009569:Nitric Oxide