Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility.
OBJECTIVE
The ataxia-telangiectasia mutated (ATM) is thought to play a major role in the caretaking of the overall genome stability, and its mutations have been implicated in human cancers. However, the role of ATM polymorphisms in oral carcinogenesis is largely unexplored. Thus, the polymorphic variants of ATM were first investigated for their association with oral cancer susceptibility.


METHODS
In this hospital-based, case-control study, associations of seven ATM single nucleotide polymorphisms with oral cancer risk in a Taiwanese population were investigated.


METHODS
A total of 620 patients with oral cancer and 620 healthy controls were genotyped and analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.


RESULTS
There were significant differences between oral cancer and control groups in the distributions of their genotypes (P = 3.71E-6) and allelic frequencies (P = 5.09E-6) in the ATM rs189037 polymorphisms. In the other six polymorphisms, there was no differential distribution between both groups. There are synergistic joint interactions of ATM genotyping with smoking, alcohol drinking, and betel quid chewing.


CONCLUSIONS
The ATM rs189037 A allele is correlated with oral cancer susceptibility, and this polymorphism may be a useful marker for oral cancer prevention and early detection.
Terry Fox Cancer Research Lab, China Medical University, Taichung, Taiwan. artbau1@yahoo.com.tw
Da-Tian
DT
Bau
Chao-Hsiang
CH
Chang
Ming-Hsui
MH
Tsai
Chang-Fang
CF
Chiu
Yung-An
YA
Tsou
Rou-Fen
RF
Wang
Chia-Wen
CW
Tsai
Ru-Yin
RY
Tsai
D000483:Alleles; D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins / Q000235:genetics*; D004260:DNA Repair; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D019869:Phosphatidylinositol 3-Kinases; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012189:Retrospective Studies; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human