Asporyergosterol, a new steroid from an algicolous isolate of Aspergillus oryzae.
Asporyergosterol (1), a new steroid with an E double bond between C-17 and C-20, was identified from the culture extracts of Aspergillus oryzae, an endophytic fungus isolated from the marine red alga Heterosiphonia japonica. Moreover, four known steroids including (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (2), (22E,24R)-3beta-hydroxyergosta-5,8,22-trien-7-one (3), (22E,24R)-ergosta-7,22-dien-3beta,5alpha,6beta-triol (4), and (22E,24R)-5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (5) were isolated. Structures of these compounds were unambiguously established by spectroscopic techniques and by comparison with literature values. All the isolates exhibited low activity to modulate acetylcholinesterase (AChE).
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Ming-Feng
MF
Qiao
Nai-Yun
NY
Ji
Xiang-Hong
XH
Liu
Fang
F
Li
Qin-Zhao
QZ
Xue
D001236:Aspergillus oryzae / Q000737:chemistry* / Q000302:isolation & purification; D018678:Cholinergic Agents / Q000302:isolation & purification*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D000461:Rhodophyta / Q000382:microbiology*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
D018678:Cholinergic Agents; D013256:Steroids; C554758:asporyergosterol; D004875:Ergosterol