Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function.
Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the CNS, where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF has become a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have consistently reported altered levels of BDNF in the circulation (i.e., serum or plasma) of patients with major depression, bipolar disorder, Alzheimer's disease, Huntington's disease and Parkinson's disease. Correlations between serum BDNF levels and affective, cognitive and motor symptoms have also been described. BDNF appears to be an unspecific biomarker of neuropsychiatric disorders characterized by neurodegenerative changes.
Laboratório de Imunofarmacologia, Departamento de Bioquímica & Imunologia, Instituto de Ciências Biológicas, UFMG Avenue Antonio Carlos, 6627 - 31270-901 - Belo Horizonte, MG, Brazil. altexr@gmail.com
Antonio Lucio
AL
Teixeira
Izabela Guimarães
IG
Barbosa
Breno Satler
BS
Diniz
Arthur
A
Kummer
D000544:Alzheimer Disease / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001714:Bipolar Disorder / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000502:physiology; D002819:Chorea / Q000378:metabolism; D003072:Cognition Disorders / Q000097:blood* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D004421:Dystonia / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000097:blood / Q000209:etiology / Q000378:metabolism; D019964:Mood Disorders / Q000097:blood* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000097:blood* / Q000209:etiology / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D010300:Parkinson Disease / Q000097:blood / Q000209:etiology / Q000378:metabolism
D000928:Antidepressive Agents; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor