Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions.
The use of inactivated poliovirus vaccines (IPV) will be required to achieve, world-wide eradication of polio. The current expense of IPV is however prohibitive for, some countries, and therefore efforts to decrease the costs of the vaccine are a high, priority. Our results show that the addition of oil-in-water emulsion adjuvants to an, inactivated trivalent poliovirus vaccine are dose-sparing and are capable of enhancing, neutralizing antibody titers in the rat potency model.
Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA. sbaldwin@idri.org
Susan L
SL
Baldwin
Christopher B
CB
Fox
Mark A
MA
Pallansch
Rhea N
RN
Coler
Steven G
SG
Reed
Martin
M
Friede
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D004655:Emulsions / Q000008:administration & dosage; D005260:Female; D009821:Oils / Q000008:administration & dosage*; D023321:Poliovirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D014611:Vaccination / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014867:Water / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D004655:Emulsions; D009821:Oils; D023321:Poliovirus Vaccines; D015164:Vaccines, Inactivated; D014867:Water