Estimating the probability of lymphedema after breast cancer surgery.
OBJECTIVE
Lymphedema is a common complication of breast cancer surgery, leading to a decreased quality of life. The risk and severity of lymphedema were associated with surgery side upper extremity infection, ≥25 kg/m(2) body mass index (BMI), and the level of hand use (LHU). Our aim was to estimate the probability of lymphedema after breast cancer surgery by using previously published incidence rates and these 3 risk factors.


METHODS
The design was a n:m matched case control study; data were analyzed on 51 patients with lymphedema and 126 available controls matched on age, radiation therapy, and operation type. In conjunction with published estimates of lymphedema, incidence rates, and estimates of the proportions of risk factor combinations in cases and controls, the Bayes' theorem was used to estimate the probability of developing lymphedema.


RESULTS
Lymphedema probabilities of 7 combinations for 6 different published calculations were used. With the assumption of 16% LE incidence rate of lymphedema, a BMI<25, no infection, and a low LHU, the estimated probability of lymphedema was 6.8%. With the assumption of 46.3% LE incidence a BMI ≥25, infection, and a high LHU led to an estimated lymphedema probability of 93.7%.


CONCLUSIONS
This study shows that control of predisposing factors in both high and low incidence rates has a marked effect on the probability of LE development. In other words, patients with low incidence for LE are more prone to develop LE if the predisposing factors are controlled poorly compared to the high incidence patients whom the predisposing factors are avoided.
Division of Surgical Oncology, Department of Surgery, Magee-Womens Hospital of University of Pittsburgh Medical Center, PA, USA. asoran@upmc.edu
Atilla
A
Soran
Wen-Chi
WC
Wu
Abuzer
A
Dirican
Ronald
R
Johnson
Oya
O
Andacoglu
John
J
Wilson
D000368:Aged; D001499:Bayes Theorem; D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008209:Lymphedema / Q000209:etiology*; D008408:Mastectomy; D008875:Middle Aged; D011183:Postoperative Complications; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome