Exogenous granulocyte colony-stimulating factor exacerbate pain-related behaviors after peripheral nerve injury.
Previous studies have demonstrated that inflammatory cells produce several mediators that can effectively counteract pain. This study was designed to test the hypothesis that exogenous administration of recombinant mouse granulocyte-colony-stimulating factor (rmG-CSF) to enhance the recruitment of inflammatory cells to painful inflamed sites could attenuate pain in a chronic neuropathic pain model in mice. Our results indicate that treatment with rmG-CSF increased several cytokines and opioid peptides content; however, it did not attenuate but exacerbate neuropathic pain. Our study highlights the potent pro-inflammatory potential of G-CSF and suggests they may be targets for therapeutic intervention in chronic neuropathic pain.
Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC.
Jiin-Tarng
JT
Liou
Ping-Wing
PW
Lui
Fu-Chao
FC
Liu
Ying-Shu
YS
Lai
Yuan-Ji
YJ
Day
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002469:Cell Separation; D016207:Cytokines / Q000096:biosynthesis; D005434:Flow Cytometry; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009437:Neuralgia / Q000276:immunology*; D018847:Opioid Peptides / Q000096:biosynthesis; D017288:Pain Threshold / Q000187:drug effects*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012584:Sciatic Nerve / Q000293:injuries / Q000601:surgery
D016207:Cytokines; D018847:Opioid Peptides; D016179:Granulocyte Colony-Stimulating Factor