High precision NOEs as a probe for low level conformers--a second conformation of strychnine.
A second conformer of strychnine, with a very low population (2.5%), has been identified experimentally, and confirmed by computation, demonstrating the ability of NOE measurements to discriminate minute contributions to dynamic structure ensembles in solution.
School of Chemistry, University of Bristol, Cantocks Close, Bristol, BS8 1TS, UK. Craig.Butts@bris.ac.uk
Craig P
CP
Butts
Catharine R
CR
Jones
Jeremy N
JN
Harvey
D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013331:Strychnine / Q000737:chemistry*
D013331:Strychnine