Formation, characterization, and fate of inhaled drug nanoparticles.
Nanoparticles bring many benefits to pulmonary drug delivery applications, especially for systemic delivery and drugs with poor solubility. They have recently been explored in pressurized metered dose inhaler, nebulizer, and dry powder inhaler applications, mostly in polymeric forms. This article presents a review of processes that have been used to generate pure (non polymeric) drug nanoparticles, methods for characterizing the particles/formulations, their in-vitro and in-vivo performances, and the fate of inhaled nanoparticles.
MAP Pharmaceuticals, Inc., Mountain View, CA 94043, USA.
Jian
J
Zhang
Libo
L
Wu
Hak-Kim
HK
Chan
Wiwik
W
Watanabe
D000280:Administration, Inhalation; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility
D004364:Pharmaceutical Preparations