Interaction of cellulose-based cationic polyelectrolytes with mucin.
Mucoadhesivity of water-soluble polymers is an important factor, when testing their suitability for controlled drug delivery systems. For this purpose, the interaction of new cationic cellulose polyelectrolytes with lyophilized mucin was investigated by means of turbidimetric titration, microscopy and measurement of zeta potential and particle size changes in the system. Results show that the cellulose derivatives interact with mucin. This interaction became stronger if cellulose macromolecules contained positively charged groups and an electrostatic interaction with the negatively charged mucin particles occurred. Under certain conditions flocculation of mucin particles by the cellulose polyelectrolyte was observed.
Department of Organic Technology, Kaunas University of Technology, Radvilenu pl. 19, Kaunas LT-50294, Lithuania. edita.mazoniene@ktu.lt
Edita
E
Mazoniene
Simona
S
Joceviciute
Jurgita
J
Kazlauske
Bernd
B
Niemeyer
Jolanta
J
Liesiene
D000818:Animals; D002412:Cations; D002482:Cellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D003636:DEAE-Cellulose / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D004573:Electrolytes / Q000378:metabolism*; D005427:Flocculation; D006863:Hydrogen-Ion Concentration; D009077:Mucins / Q000378:metabolism*; D009391:Nephelometry and Turbidimetry; D010316:Particle Size; D011199:Potentiometry; D012995:Solubility; D055672:Static Electricity; D013499:Surface Properties; D034421:Sus scrofa; D014867:Water
D002412:Cations; D004573:Electrolytes; D009077:Mucins; D014867:Water; D002482:Cellulose; C002283:hydroxyethylcellulose; D003636:DEAE-Cellulose