Ubiquitin: same molecule, different degradation pathways.
Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrate toward a particular route of degradation likely include ubiquitin chain length and linkage type, which may favor interaction with particular receptors or confer differential susceptibility to deubiquitinase activities associated with each pathway.
Institute of Translational Medicine, University of Liverpool, UK. clague@liv.ac.uk
Michael J
MJ
Clague
Sylvie
S
Urbé
D000818:Animals; D001343:Autophagy; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D025801:Ubiquitin / Q000737:chemistry / Q000378:metabolism*
D011506:Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex