Glycosylated nordihydroguaiaretic acids as anti-cancer agents.
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC. jrhwu@mx.nthu.edu.tw
Jih Ru
JR
Hwu
Chuan-I
CI
Hsu
Ming-Hua
MH
Hsu
Yu-Chuan
YC
Liang
Ru Chih C
RC
Huang
Yuan C
YC
Lee
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D045744:Cell Line, Tumor; D005697:Galactosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D006031:Glycosylation; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D009637:Masoprocol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use
D000970:Antineoplastic Agents; D005697:Galactosides; D005960:Glucosides; D014230:Triazoles; D009637:Masoprocol