In vivo evaluation of two types of bioactive scaffold used for tendon-bone interface healing in the reconstruction of anterior cruciate ligament.
Fibrin glue combined with bone morphogenetic protein (BMP) and recombined bone xenograft (RBX), were compared to evaluate their effect on the tendon-bone interface healing. The interface of fibrin glue-BMP developed new cartilage but the new bone was thinner whereas the interface of RBX had large areas of chondrocyte-like cells, bone formation and an immature neo-enthesis structure. At 12 weeks, bone mineral density of RBX group (152 ± 52 cm(3)) and fibrin glue-BMP group (109 ± 13 cm(3)) was calculated by micro-computed tomography. The ultimate load of fibrin glue-BMP group (60 ± 18 and 51 ± 14 N) and RBX group (65 ± 21 and 57 ± 15 N) was shown by biomechanics at 6 and 12 weeks. RBX thus has an advantage on accelerating tendon-bone interface healing.
Department of Orthopaedics, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
Weibin
W
Zhang
Weimin
W
Pan
Mingjun
M
Zhang
Yiyong
Y
Wei
D000818:Animals; D016118:Anterior Cruciate Ligament / Q000254:growth & development / Q000601:surgery; D001696:Biomechanical Phenomena; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000648:ultrastructure; D001842:Bone and Bones / Q000378:metabolism*; D015718:Fibrin Tissue Adhesive / Q000737:chemistry; D011817:Rabbits; D019651:Plastic Surgery Procedures; D013710:Tendons / Q000378:metabolism*; D054457:Tissue Scaffolds / Q000592:standards*; D014945:Wound Healing
D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive