A computational model of hemodynamic parameters in cortical capillary networks.
The analysis of hemodynamic parameters and functional reactivity of cerebral capillaries is still controversial. To assess the hemodynamic parameters in the cortical capillary network, a generic model was created using 2D voronoi tessellation in which each edge represents a capillary segment. This method is capable of creating an appropriate generic model of cerebral capillary network relating to each part of the brain cortex because the geometric model is able to vary the capillary density. The modeling presented here is based on morphometric parameters extracted from physiological data of the human cortex. The pertinent hemodynamic parameters were obtained by numerical simulation based on effective blood viscosity as a function of hematocrit and microvessel diameter, phase separation and plasma skimming effects. The hemodynamic parameters of capillary networks with two different densities (consistent with the variation of the morphometric data in the human cortical capillary network) were analyzed. The results show pertinent hemodynamic parameters for each model. The heterogeneity (coefficient variation) and the mean value of hematocrits, flow rates and velocities of the both network models were specified. The distributions of blood flow throughout the both models seem to confirm the hypothesis in which all capillaries in a cortical network are recruited at rest (normal condition). The results also demonstrate a discrepancy of the network resistance between two models, which are derived from the difference in the number density of capillary segments between the models.
Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Ilam St, Christchurch, New Zealand.
Navid
N
Safaeian
Department of Mechanical Engineering, University of Canterbury, Ilam St, Christchurch, New Zealand.
Mathieu
M
Sellier
Centre for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Ilam St, Christchurch, New Zealand.
Tim
T
David
D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D002196:Capillaries / Q000033:anatomy & histology / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006400:Hematocrit; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D008955:Models, Cardiovascular