[Waist circumference below metabolic syndrome harmonizing criteria is associated with increased cardiovascular risk].
OBJECTIVE
To test the hypothesis that waist circumference (WC) just below Joint Interim Statement ([JIS], 2009) abdominal obesity thresholds can be associated with worse risk factors profile than smaller WC.


METHODS
In a study of risk factors in families of patients with "premature" coronary heart disease (CHD) we examined 229 persons without CHD with body mass index (BMI) 18.5 kg/m and WC <94 cm (men) or <80 cm (women) (67 spouses [28-62 years] and 162 children [16-37 years]) of probands. Risk factors studied included smoking, BMI, WC, BP, total and high density lipoprotein cholesterol (HDL C), triglycerides (TG), basal serum glucose, diabetes and metabolic syndrome (MS JIS criteria, 2009). High BP was defined as prehypertension (PreHT) or hypertension (HT) and named PreHT/HT. In persons aged 16-17 years we used criteria 4 th report of National High BP Education Program Working Group on High BP in Children and Adolescents, in persons 18 years - 7 th Joint National Committee Report (USA). TG 1.7 mmol/l, serum basal glucose 5.6 mmol/l were defined high, HDL C <1.0 mmol/l (men), <1.3 mmol/l (women) - low. Framingham risk score of cardiovascular disease (CVD) was calculated for persons aged 30 years. Factors associated with various ranges of WC were selected by logistical regression univariate analysis. Odds ratios were compared in 2 groups of WC distribution: top ( 83 cm men, 73 cm women - intermediate [I] WC) vs 2 lower (<83 cm men; <73 cm women) tertiles. Analysis was carried out in 2 age groups according to median age: 16-26 years (n=115, 23.5% with IWC) and 27-62 years (n=114, 50.0 % with IWC).


RESULTS
Persons aged 16-26 years with IWC had significantly higher risk to have high TG, low HDL C and PreHT/HT than those with smaller WC: odds ratios 7.53 (95% confidence interval [CI] 1.69-33.6; p=0.008), 3.56 (95% CI 1.35-9.36; p=0.010) and 2.22 (95% CI 1.13-4.36; p=0.020), respectively. No significant relationship was found between IWC and registered risk factors in age group 27-62 years. In persons aged 30-62 years (n=90, 51.1% with IWC) IWC was related to presence of 5% Framingham risk score: OR vs smaller WC 2.59 (95% CI 1.01-6.67; p=0.048).


CONCLUSIONS
Among younger consorts and adult children of patients with "premature" CHD persons with WC 83 - <94 cm (men), 73 - <80 cm (women) had worse risk factors profile compared with persons with smaller WC.
M V
MV
Konnov
L M
LM
Dobordzhinidze
A D
AD
Deev
N A
NA
Gratsianskiĭ
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology* / Q000209:etiology / Q000523:psychology; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D008875:Middle Aged; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D055105:Waist Circumference
D008076:Cholesterol, HDL