[Control of bone remodeling by nervous system. Nerve distribution and pain in bone tissue].
The nerve fibers extensively innervate bone such as periosteum, compact and trabecular bone, and bone marrow space. Regarding as nerve fibers, there are myelinated fibers as Aβ and Aδ fibers, and unmyelinated fibers as C fiber, further, sympathetic nerve fibers also innervated bone tissue. In addition to nerve fibers, several receptors such as nociceptors at the terminal of the fibers, and released many kinds of neuropeptides were identified in the bone. On the other hand, most of roles concerning the nerve fibers, receptors and neuropeptides in bone were still unknown. Recently, bone pain of musculoskeletal disease is recognized to be related pathological condition at increasing bone resorption. It is thought to be a mechanism that a highly acidic condition at a bone compartment due to proton released from activated osteoclast stimulated acid sensing receptor as a nociceptor, and afferent signal induced bone pain.
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Kousuke
K
Iba
Toshihiko
T
Yamashita
D000818:Animals; D001862:Bone Resorption / Q000473:pathology; D001842:Bone and Bones / Q000294:innervation*; D006801:Humans; D051379:Mice; D009140:Musculoskeletal Diseases / Q000209:etiology / Q000473:pathology; D009412:Nerve Fibers / Q000502:physiology*; D009479:Neuropeptides / Q000378:metabolism / Q000502:physiology; D009619:Nociceptors / Q000378:metabolism / Q000502:physiology*; D010010:Osteoclasts / Q000378:metabolism; D010024:Osteoporosis; D010146:Pain / Q000209:etiology* / Q000503:physiopathology; D011522:Protons
D009479:Neuropeptides; D011522:Protons