Is there an association between non-steroidal anti-inflammatory drugs and contrast nephropathy?
BACKGROUND
The association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and acute or chronic renal failure is well documented, but evidence of such association between NSAIDs and Contrast-Induced Nephropathies (CIN) is not found in the indexed literature.


OBJECTIVE
To evaluate the possible association between NSAIDs and CIN.


METHODS
In a cohort study, through clinical interviews of patients that underwent cardiac catheterization, we analyzed the use of NSAIDs and its association with the development of CIN, through alterations in serum creatinine or glomerular filtration rate in 48 or 72 hours.


RESULTS
From July 2005 to July 2006, 236 patients were enrolled in the study, of which 29 were later excluded. The incidence of CIN was 10.37% (20 of 207) and 42% of the patients were using NSAIDs until the moment of the evaluation. There was no association between the use of NSAIDs and the development of CIN with OR of 1.293 95% CI (0.46-4.2). The study detected known risk factors for the development of CIN, such as diabetes with OR of 2.77 95%CI (1.05-7.47) and chronic renal failure with OR 3.48 95%CI (1.1-11.07). A protective action of saline solution hydration is also suggested, with OR of 0.166 95%CI (0.03-0.92).


CONCLUSIONS
Based on the data obtained, we conclude that there was no association between CIN and previous use of NSAIDs, at least with an OR higher then 2.85, which our sample detected.
Hospital São Lucas da PUCRS, Porto Alegre, RS, Brasil. luciano.diogo@pucrs.br
Luciano Passamani
LP
Diogo
David
D
Saitovitch
Michelle
M
Biehl
Laura Fuchs
LF
Bahlis
Maria Claudia
MC
Guterres
Cinthia Fonseca
CF
O'Keeffe
Gustavo Franco
GF
Carvalhal
Paulo Ricardo Avancini
PR
Caramori
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006328:Cardiac Catheterization; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000378:metabolism; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003287:Contrast Media; D003404:Creatinine