[Prevention of chronic allograft nephropathy].
Chronic allograft nephropathy, characterized by interstitial fibrosis and tubular atrophy, is one of the main causes of allograft failure in the long term. It may be induced by several factors, immunogical or not in nature, which nephrologists must recognize in order to establish the appropriate treatment strategy and prevent progressive loss of graft function. Extensive use of graft biopsy, whether carried out by protocol or suggested by the clinical setting, is recommended for an accurate diagnosis of renal lesions and prompt identification of calcineurin inhibitor-induced toxicity or signs of immunological activity (i.e., subclinical rejection or chronic antibody-mediated rejection) requiring changes of immunosuppressive strategy.
Nefrologia e Dialisi, Ospedali Riuniti, Ancona, Italy. gm.frasca@ospedaliriuniti.marche.it
Giovanni M
GM
Frascà
Valentina
V
Nastasi
Emilio
E
Balestra
Giovanni
G
Gaffi
Domenica
D
Taruscia
Mario
M
D'Arezzo
Sibilla
S
Sagripanti
D002908:Chronic Disease; D006801:Humans; D007674:Kidney Diseases / Q000517:prevention & control*; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000517:prevention & control*