Apoptotic and non-apoptotic caspase functions in neural development.
During neural development, massive cell death occurs in both vertebrates and invertebrates. Caspase is a central player in apoptosis that is evolutionally conserved. Genetic manipulation of the caspase activity in Drosophila and mice has revealed that caspases control cell fate through apoptotic and non-apoptotic mechanisms, to ensure appropriate cell differentiation and maturation in the developing nervous system.
Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo and CREST, JST, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. miura@mol.f.u-tokyo.ac.jp
Masayuki
M
Miura
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D017173:Caenorhabditis elegans; D020169:Caspases / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D051379:Mice; D055495:Neurogenesis / Q000502:physiology*
D020169:Caspases