Therapy for cerebral ischemic injury with erythropoietin-containing nanoparticles.
In this study we prepared nanocarrier of erythropoietin (EPO) and the curative effect of the EPO-containing nanoparticles for periventricular leukomalacia (PVL) model was validated. It was demonstrated that EPO-containing nanoparticles can ameliorate drug-induced liquefaction caused by hypoxia. EPO-containing nanomedicine may open new therapeutic strategies in hypoxia cure.
State key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China.
Nongyue
N
He
Ting
T
Wang
Li
L
Jiang
Daxin
D
Wang
Yan
Y
Hu
Long
L
Zhang
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004921:Erythropoietin / Q000008:administration & dosage*; D019084:Fluorescent Antibody Technique, Indirect; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D058726:Nanoconjugates / Q000008:administration & dosage*; D009836:Oligodendroglia / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D058726:Nanoconjugates; D004921:Erythropoietin