Deuteromycols A and B, two benzofuranoids from a Red Sea marine-derived Deuteromycete sp.
Two benzofuranoids, deuteromycol A, 6,7-dihydroxy-2-[1'-hydroxy-(1'→5″)-2″,3″,4″-trihydroxy-2″,3″-dihydropyran]benzofuran and deuteromycol B, 1-(6,7-dihydroxy benzofuran-2-yl)methyl acetate have been isolated from the ethanol extract of the marine-derived fungal strain MF 003 (Deuteromycete) obtained from Red Sea mangrove drift wood. Deuteromycols A and B contain a catecholic nucleus that to the best of our knowledge is unusual in association with marine fungi secondary metabolites. Structures were established on the basis of extensive 1D-and 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. Besides, the extracts exhibited in vitro antibacterial activity.
Department of Phytochemistry, National Research Centre, Dokki, Cairo, Egypt. mahmoudnawwarhesham@yahoo.com
Mahmoud
M
Nawwar
Sahar
S
Hussein
Nahla A
NA
Ayoub
Amani
A
Hashim
Gudrun
G
Mernitz
Beate
B
Cuypers
Michael
M
Linscheid
Ulrike
U
Lindequist
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019156:Indian Ocean; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D013210:Staphylococcus / Q000187:drug effects; D014934:Wood
D000900:Anti-Bacterial Agents; D001572:Benzofurans; C558504:deuteromycol A; C558505:deuteromycol B