Enantioselective synthesis of A key A-ring intermediate for the preparation of 1α,25-dihydroxyvitamin D(3).
A novel approach to the key A-ring α, β-unsaturated aldehyde 1, an important intermediate for the preparation of 1α,25-dihydroxyvitamin D(3), has been developed. The strategy started from the inexpensive starting material (R)-carvone with an ene reaction serving as the key step toward the potential synthesis of vitamin D(3) analogues bearing the modification at the C-2 position.
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. cylcy2005@yahoo.com.cn
Yan
Y
Chen
Tong
T
Ju
D000179:Acrylates / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D000179:Acrylates; C118756:dihydroxy-vitamin D3; D014807:Vitamin D; C036658:acrylic acid