Effect of nanodisperse ferrite cobalt (CoFe2O4) particles on contractile reactions in guinea pigs airways.
The effect of nanopowder CoFe(2)O(4)on contractile responses of smooth-muscle segments of guinea pigs airways was studied by mechanography. Both in vivo inhalation of nanopowder aerosol or in vitro application of nanopowder to isolated airway segments increased the amplitude of contractile responses to histamine and potentiated the dilatory reaction to adrenergic salbutamol.
Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia.
L V
LV
Kapilevich
E Yu
EY
D'yakova
A V
AV
Nosarev
T N
TN
Zaitseva
Z R
ZR
Petlina
L M
LM
Ogorodova
B G
BG
Ageev
A A
AA
Magaeva
V I
VI
Itin
O G
OG
Terekhova
D000280:Administration, Inhalation; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D003035:Cobalt; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*
D003035:Cobalt; D006632:Histamine; D000420:Albuterol