Serum paraoxonase 1 activity in women with metabolic syndrome.
BACKGROUND
Metabolic syndrome (MetS) is a leading risk factor for coronary artery disease (CAD) in women. Reduced paraoxonase 1 (PON1) activity may play a role in the pathogenesis of atherosclerosis through increased susceptibility to lipid peroxidation in patients with MetS.


OBJECTIVE
To examine whether there is a relationship between serum PON1 activity and MetS in women.


METHODS
The study group consisted of 54 women with MetS. The NCEP ATP III guidelines were used to define MetS. The control group consisted of 65 women without MetS and CAD. All patients from the MetS group underwent coronary angiography.


RESULTS
The PON1 activity and salt-stimulated PON1 activity were not significantly altered in women with MetS when compared to controls (p = 0.902, p = 0.877, respectively). There was no significant difference in PON1 activity (p = 0.159), and salt-stimulated PON1 activity (p = 0.139) between diabetics and non-diabetics. In the MetS group, patients with CAD (n = 16) had significantly reduced PON1 activity and salt-stimulated PON1 activity compared to MetS patients without CAD (p = 0.008 and p = 0.004, respectively).


CONCLUSIONS
Serum PON1 activity is significantly reduced in women with CAD and MetS. MetS per se does not alter serum PON1 activities.
Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Centre, Istanbul, Turkey. haleyilmaz@tnn.net
Hale
H
Yilmaz
Nurten
N
Sayar
Mehmet
M
Yilmaz
Ufuk
U
Gurkan
Cenk
C
Sesal
Rodi
R
Tosu
Nazmiye
N
Cakmak
Betul
B
Erer
Dilaver
D
Oz
Figen
F
Ciloglu
Osman
O
Bolca
D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000201:enzymology*; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000201:enzymology*; D008875:Middle Aged; D012307:Risk Factors
D043303:Aryldialkylphosphatase