A multiple primary carcinoma consisting of leukoplakia and SCC: a case report with p53 mutation analysis.
Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a single 67-year-old Japanese man. A p53 mutation was detected in two of the three SCCs and one of the three leukoplakias. One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). This case showed that individual oral tumours may have different genetic changes even when they develop in a single patient. Therefore, this report provided strong evidence that in cases of multiple tumours it is necessary to design tailor-made therapies for each individual tumour rather than a single standardised therapy for all multiple tumours.
Department of Oral and Maxillofacial Surgery, Division of Oncological Science Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Nur Mohammad Monsur
NM
Hassan
Mitsuhiro
M
Tada
Masanobu
M
Shindoh
Jun-Ichi
J
Hamada
Haruhiko
H
Kashiwazaki
Tsuyoshi
T
Shimo
Yuichi
Y
Ashikaga
Yutaka
Y
Yamazaki
Akira
A
Sasaki
Tetsuya
T
Moriuchi
Nobuo
N
Inoue
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D003062:Codon / Q000235:genetics; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D006801:Humans; D007971:Leukoplakia / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D003062:Codon; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53