Cytotoxic thiocarbamate derivatives of boldine.
Two new boldine derivatives: the 3-thiocarbamateboldine (3) and the 2,9-O,O-diacetyl-3-thiocarbamateboldine (4) have been synthesized and their cytotoxicity evaluated.
Departamento de Química, Universidad Técnica Federico Santa Maria, Avenida España No 1680, Casilla 110-V, Valparaíso, Chile.
Franz A
FA
Thomet
Pablo
P
Pinyol
Joan
J
Villena
Luis J
LJ
Espinoza
Patricio G
PG
Reveco
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D001060:Aporphines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D031611:Peumus / Q000737:chemistry*; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification
C554761:2,9-O,O-diacetyl-3-thiocarbamateboldine; C554760:3-thiocarbamateboldine; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D013859:Thiocarbamates; C011686:boldine