SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population.
Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210,785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P = 5.3 × 10(-13), odds ratio = 0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI.
Laboratory for Cardiovascular Disease, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
Asako
A
Aoki
Kouichi
K
Ozaki
Hiroshi
H
Sato
Atsushi
A
Takahashi
Michiaki
M
Kubo
Yasuhiko
Y
Sakata
Yoshihiro
Y
Onouchi
Takahisa
T
Kawaguchi
Tsung-Hsien
TH
Lin
Hitoshi
H
Takano
Masahiro
M
Yasutake
Po-Chao
PC
Hsu
Shiro
S
Ikegawa
Naoyuki
N
Kamatani
Tatsuhiko
T
Tsunoda
Suh-Hang H
SH
Juo
Masatsugu
M
Hori
Issei
I
Komuro
Kyoichi
K
Mizuno
Yusuke
Y
Nakamura
Toshihiro
T
Tanaka
D000465:Algorithms; D044466:Asian People / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D054928:Validation Studies as Topic