Metastasis suppression: a role of the Dice(r).
Recent studies have implicated the microRNA biogenesis enzyme Dicer as a suppressor of breast carcinoma metastasis and elucidated upstream signaling pathways that control Dicer levels.
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Scott
S
Valastyan
Robert A
RA
Weinberg
D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D016153:Genes, Suppressor; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis / Q000235:genetics*; D043244:Ribonuclease III / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation
D035683:MicroRNAs; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D043244:Ribonuclease III