Breast cancer and HIV in the era of highly active antiretroviral therapy: two case reports and review of the literature.
The incidence of human immunodeficiency virus (HIV) infection is rising in US women; however its impact on breast cancer incidence, stage at presentation, response and treatment toxicity remains unknown. To address the impact of HIV infection and use of highly active antiretroviral therapy (HAART) on the natural history of breast cancer we present two cases of breast cancer in HIV-infected women and also review the literature. A literature search was done on Medline using the key words HIV/AIDS, breast cancer, and HAART therapy, restricted to English language. There were mostly case reports and one large series of 20 cases reported by Hurley et al. Data concerning the impact of HIV infection and HAART therapy regarding pathogenesis, stage at presentation, tumor type, response, and toxicity associated with treatment were reviewed. The literature review shows that the breast cancer incidence is either same or less in HIV-infected patients compared to the general population. However, the patients with HIV infection present with more advanced stage and aggressive disease, and they also have poor chemotherapy tolerance. The impact of HAART on breast cancer incidence in HIV-infected patients is still unclear.
Department of Hematology/Oncology, University of Florida College of Medicine, Jacksonville, Florida, USA. naeem.latif@jax.ufl.edu
Naeem
N
Latif
Fauzia
F
Rana
Troy
T
Guthrie
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001943:Breast Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008408:Mastectomy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010490:Pericardial Effusion / Q000188:drug therapy / Q000209:etiology; D016066:Pleural Effusion, Malignant / Q000188:drug therapy / Q000209:etiology; D049268:Positron-Emission Tomography; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis
D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human