A database of frequency distributions of energy depositions in small-size targets by electrons and ions.
Linear energy transfer (LET) is an average quantity, which cannot display the stochastics of the interactions of radiation tracks in the target volume. For this reason, microdosimetry distributions have been defined to overcome the LET shortcomings. In this paper, model calculations of frequency distributions for energy depositions in nanometre size targets, diameters 1-100 nm, and for a 1 μm diameter wall-less TEPC, for electrons, protons, alpha particles and carbon ions are reported. Frequency distributions for energy depositions in small-size targets with dimensions similar to those of biological molecules are useful for modelling and calculations of DNA damage. Monte Carlo track structure codes KURBUC and PITS99 were used to generate tracks of primary electrons 10 eV to 1 MeV, and ions 1 keV µm(-1) to 300 MeV µm(-1) energies. Distribution of absolute frequencies of energy depositions in volumes with diameters of 1-100 nm randomly positioned in unit density water irradiated with 1 Gy of the given radiation was obtained. Data are presented for frequency of energy depositions and microdosimetry quantities including mean lineal energy, dose mean lineal energy, frequency mean specific energy and dose mean specific energy. The modelling and calculations presented in this work are useful for characterisation of the quality of radiation beam in biophysical studies and in radiation therapy.
Radiation Biophysics Group, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. hooshang.nikjoo@ki.se
H
H
Nikjoo
S
S
Uehara
D
D
Emfietzoglou
L
L
Pinsky
D003198:Computer Simulation; D016208:Databases, Factual; D004579:Electron Transport; D007477:Ions; D018499:Linear Energy Transfer; D008956:Models, Chemical; D015233:Models, Statistical; D009010:Monte Carlo Method
D007477:Ions