Invasive procedures for fetal karyotyping: no cause of subsequent gestational hypertension or pre-eclampsia.
The aim was to estimate the risk of maternal hypertensive complications following first- or second-trimester invasive diagnostic procedures, i.e. chorionic villus sampling (CVS) and amniocentesis (AC). Odds ratios (ORs) for gestational hypertension, mild pre-eclampsia or severe pre-eclampsia were calculated for women who underwent CVS (n = 1,984) or AC (n = 21,748) compared with non-exposed women (n = 47,854). No increase in the development of gestational hypertension, mild pre-eclampsia or severe pre-eclampsia was observed. The results do not support an association between invasive procedures for fetal karyotyping and subsequent gestational hypertension or pre-eclampsia.
Centre for Epidemiology, The Swedish National Board of Health and Welfare, Stockholm, Sweden. peter.lindgren@kbh.uu.se
P
P
Lindgren
M
M
Cederholm
B
B
Haglund
O
O
Axelsson
D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology*; D007621:Karyotyping / Q000379:methods*; D008423:Maternal Age; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D018570:Risk Assessment; D013548:Sweden