An efficient paradigm for genetic epidemiology cohort creation.
Development of novel methodologies to efficiently create large genetic epidemiology cohorts is needed. Here we describe a rapid, precise and cost-efficient method for collection of DNA from cases previously experiencing an osteoporotic fracture by identifying cases using and administrative health-care databases. Over the course of 14 months we collected DNA from 1,130 women experiencing an osteoporotic fracture, at a cost of $54 per sample. This cohort is among the larger DNA osteoporotic fracture collections in the world. The novel method described addresses a major unmet health care research need and is widely applicable to any disease that can be identified accurately through administrative data.
Department of Human Genetics, McGill University, Jewish General Hospital, Montreal, Canada.
Martin
M
Ladouceur
William D
WD
Leslie
Zari
Z
Dastani
David
D
Goltzman
J Brent
JB
Richards
D000368:Aged; D015331:Cohort Studies; D004247:DNA / Q000302:isolation & purification*; D005260:Female; D006302:Health Services Research / Q000379:methods; D006801:Humans; D008350:Manitoba / Q000453:epidemiology; D008875:Middle Aged; D017720:Molecular Epidemiology / Q000191:economics / Q000379:methods*; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000453:epidemiology; D058866:Osteoporotic Fractures / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D015203:Reproducibility of Results; D012463:Saliva / Q000378:metabolism
D004247:DNA