Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations.
There are no reports about epidermal growth factor receptor (EGFR) mutations and the responsiveness to pemetrexed treatment. In order to understand the influence of EGFR mutations on pemetrexed response, we performed EGFR sequencing of lung adenocarcinoma from patients undergoing pemetrexed treatment and analyzed their response to pemetrexed. The pemetrexed-treated lung adenocarcinoma patients with adequate specimens for EGFR sequencing and measurable target lesions were enrolled for response analysis. Demographic data, EGFR mutation status, response to pemetrexed, and survival data were collected. From January 2004 to December 2008, 156 patients with measurable target lesions and EGFR sequencing results had complete clinical data for analysis. The patients with EGFR mutations (N=93) had a better response rate (p=0.016) and longer progression-free survival (PFS) (p=0.030) than those with wild type EGFR (N=63). By multivariate analysis, those who had better performance status (p=0.013) and EGFR mutations (p=0.021) had a longer PFS. In conclusion, lung adenocarcinoma patients receiving pemetrexed with EGFR mutations have a better response rate and longer PFS than those with wild type EGFR.
Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan.
Shang-Gin
SG
Wu
Chih-Hsin
CH
Yang
Chong-Jen
CJ
Yu
Jih-Hsiang
JH
Lee
Ya-Chieh
YC
Hsu
Yih-Leong
YL
Chang
Jin-Yuan
JY
Shih
Pan-Chyr
PC
Yang
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis; D018572:Disease-Free Survival; D005260:Female; D005971:Glutamates / Q000008:administration & dosage* / Q000009:adverse effects; D049452:Green Fluorescent Proteins / Q000235:genetics*; D006147:Guanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009367:Neoplasm Staging; D000068437:Pemetrexed
D005971:Glutamates; C485184:enhanced green fluorescent protein; D000068437:Pemetrexed; D049452:Green Fluorescent Proteins; D006147:Guanine