Ovulation rate in adolescents with type 1 diabetes mellitus.
OBJECTIVE
To study ovulation in adolescents with type 1 diabetes (T1D) and the effect of hemoglobin A1c (HbA1c) levels on their ovulatory function.


METHODS
Prospective investigation.


METHODS
Academic research institute.


METHODS
Adolescents with T1D (n=31) and healthy girls (n=52).


METHODS
Ovulation assessed through the measurement of salivary progesterone (days 13, 18, 23, and 28 of each cycle).


METHODS
Proportion of ovulatory cycles.


RESULTS
A total of 168 and 281 menstrual cycles were studied in the T1D and control girls, respectively. Metabolic control was defined as optimal if HbA1c was <7.5%. The proportion of ovulatory cycles was similar in the TID and control groups (34.5% and 36.3%, respectively). Regression analyses showed that the presence of T1D did not have a statistically significant effect on the ovulatory rate. However, more ovulatory cycles were observed in girls with T1D who had optimal metabolic control compared with those who had insufficient control (51.3% vs. 29.4%).


CONCLUSIONS
In adolescent girls, T1D did not affect the rate of ovulation. A higher ovulatory rate was observed in those with optimal control compared with those with insufficient metabolic control, but a substantial proportion of ovulatory cycles were still observed in patients with higher HbA1c levels.
Institute of Maternal and Child Research, School of Medicine, University of Chile, San Borja Arriarán Hospital, Santiago, Chile. ecodner@med.uchile.cl
Ethel
E
Codner
Francisca C
FC
Eyzaguirre
Germán
G
Iñiguez
Patricia
P
López
Francisco
F
Pérez-Bravo
Isabel M
IM
Torrealba
Fernando
F
Cassorla
D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D005298:Fertility / Q000502:physiology*; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008572:Menarche / Q000502:physiology; D010053:Ovary / Q000502:physiology*; D010060:Ovulation / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000378:metabolism / Q000503:physiopathology; D011374:Progesterone / Q000378:metabolism; D011446:Prospective Studies; D012463:Saliva / Q000378:metabolism
D006442:Glycated Hemoglobin; D011374:Progesterone; C517652:hemoglobin A1c protein, human