The growing diversity and spectrum of action of myeloid-derived suppressor cells.
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of myelomonocytic cells endowed with suppressive activity. MDSC expand and acquire suppressive functions in chronic inflammatory conditions, in particular in neoplastic disorders. As exemplified in two reports in this issue of the European Journal of Immunology, progress has been made in defining MDSC-inducing signals, MDSC phenotypic diversity and spectrum of action. These recent results provide a basis to better define the relationship of MDSC with the adaptive immune responses of mononuclear phagocytes and neutrophils and to exploit their function in a therapeutic setting.
Istituto Clinico Humanitas IRCCS, University of Milan, Rozzano, Milan, Italy. alberto.mantovani@humanitasresearch.it
Alberto
A
Mantovani
D000818:Animals; D000950:Antigens, Ly; D002454:Cell Differentiation; D003602:Cytotoxicity, Immunologic; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D053583:Interleukin-1beta / Q000276:immunology*; D051379:Mice; D022423:Myeloid Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D043882:Receptors, Cannabinoid / Q000276:immunology*; D019139:Tumor Escape
D000950:Antigens, Ly; D053583:Interleukin-1beta; C494192:Ly-6C antigen, mouse; D043882:Receptors, Cannabinoid