[Control of bone remodeling by nervous system. Nervous system and bone].
The relationship between bone and nervous system has been considered based on clinical observations such as Reflex Sympathetic Dystrophy (RSD) or ectopic bone formation associated with spinal cord injury. Sympathtic nervous tone has been reported to control both bone formation and bone resorption. Unloading induces bone loss due to an increase in bone resorption and decrease in bone formation. Both of these two arms are shown to be influenced by sympathetic tone. In addition, cannabinoid receptor has been observed to be involved in regulation of bone mass. Psychiatric diseases such as depression has also been suggested to linked to the alteration in the levels of bone mass. These observations together point to importance of the relationship between bone mass and nervous system.
Department of Molecular Pharmacology, Division of Advanced Molecular Medicine, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Masaki
M
Noda
Masashi
M
Nagao
Ryo
R
Hanyu
Fumitaka
F
Mizoguchi
Takuya
T
Notomi
Tadayoshi
T
Hayata
Tetsuya
T
Nakamoto
Yoichi
Y
Ezura
D000818:Animals; D015519:Bone Density; D001862:Bone Resorption / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism*; D003863:Depression / Q000378:metabolism; D006801:Humans; D051379:Mice; D009411:Nerve Endings / Q000502:physiology; D010012:Osteogenesis; D043882:Receptors, Cannabinoid / Q000502:physiology; D012019:Reflex Sympathetic Dystrophy / Q000209:etiology; D015398:Signal Transduction / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*
D043882:Receptors, Cannabinoid