Antifungal activity of flavonoids isolated from mango (Mangifera indica L.) leaves.
Five flavonoids, namely (-)-epicatechin-3-O-β-glucopyranoside (1), 5-hydroxy-3-(4-hydroxylphenyl)pyrano[3,2-g]chromene-4(8H)-one (2), 6-(p-hydroxybenzyl)taxifolin-7-O-β-D-glucoside (tricuspid) (3), quercetin-3-O-α-glucopyranosyl-(1 → 2)-β-D-glucopyranoside (4) and (-)-epicatechin(2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol (5), were isolated from the leaves of mango (Mangifera indica L.). Antifungal activity of these compounds was evaluated against five fungal species, namely Alternaria alternata (Fr.) Keissler, Aspergillus fumigatus Fresenius, Aspergillus niger van Tieghem, Macrophomina phaseolina (Tassi) Goid. and Penicillium citrii. Six concentrations, namely 100, 300, 500, 700, 900 and 1000 ppm of each of the five flavonoids were employed by means of the poisoned medium technique. All concentrations of the five test flavonoids significantly suppressed fungal growth. However, the specificity of different test compounds was evident against different fungal species. In general, antifungal activity of the flavonoids was gradually increased by increasing their concentrations. The highest concentration (of 1000 ppm) of compounds 1-5 reduced the growth of different target fungal species by 63-97%, 56-96%, 76-99%, 76-98% and 82-96%, respectively.
Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
Qudsia
Q
Kanwal
Ishtiaq
I
Hussain
Hamid
H
Latif Siddiqui
Arshad
A
Javaid
D000704:Analysis of Variance; D000935:Antifungal Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D031022:Mangifera / Q000737:chemistry*; D015394:Molecular Structure; D010154:Pakistan; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013045:Species Specificity
D000935:Antifungal Agents; D005419:Flavonoids; D010936:Plant Extracts