Amplification of G-quadruplex DNAzymes using PCR-like temperature cycles for specific nucleic acid and single nucleotide polymorphism detection.
A nucleic acid sensor, based on the amplified formation of G-quadruplex DNAzymes by polymerase chain reaction (PCR)-like temperature cycles, was developed. This "turn-on" process allowed effective detection of specific nucleic acid targets and identification of single nucleotide polymorphisms (SNPs).
Key Laboratory of Functional Polymer Materials, Ministry of Education, Nankai University, Tianjin, 300071, People's Republic of China.
Na
N
Wang
De-Ming
DM
Kong
Han-Xi
HX
Shen
D001483:Base Sequence; D021881:DNA, Catalytic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D054856:G-Quadruplexes; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D009696:Nucleic Acids / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D013696:Temperature
D021881:DNA, Catalytic; D009696:Nucleic Acids