Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-Hodgkin lymphoma risk.
Kaposi sarcoma-associated herpes virus (KSHV) infects B-cells and is found in non-Hodgkin lymphoma (NHL) B-cell tumors and could therefore contribute to the occurrence of NHL. We performed a nested case-control study including 155 incident NHL cases and matched noncancer controls. Pre-NHL serum was tested for KSHV DNA and antibodies. Serum KSHV DNA was more common in cases than controls (14% versus 6%, P = 0.03), but after adjustment, the difference was not significant. Epstein-Barr virus serum DNA was similarly unassociated with NHL as were KSHV antibodies. KSHV is not a primary cause of NHL in HIV-infected men who have sex with men.
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Daniel C
DC
Beachler
Lan L
LL
Gellert
Lisa P
LP
Jacobson
Richard F
RF
Ambinder
Elizabeth C
EC
Breen
Otoniel
O
Martínez-Maza
Charles S
CS
Rabkin
Charles C
CC
Rabkin
Richard A
RA
Kaslow
Gypsyamber
G
D'Souza
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D004279:DNA, Viral / Q000097:blood*; D015658:HIV Infections / Q000150:complications; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000276:immunology / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral