[Prescription design and dissolution evaluation of self-emulsifying drug delivery systems of baicalin].
OBJECTIVE
To improve dissolution and bioavailability of baicalin in solid prescription and screen the prescription of self-emulsifying drug delivery systems of baicalin.


METHODS
Orthogonal test was applied to optimize the prescription of self-emulsifying drug delivery systems of baicalin, and the best prescription was selected by comprehensive evaluation of emulsion speed, size and light transmission rate.


RESULTS
The best quantity ratio of self-emulsifying drug delivery systems of baicalin was baicalin: polysorbate 80: oliver oil: glycerol = 0.15 : 1 : 1 : 1.5.


CONCLUSIONS
Self-emulsifying drug delivery systems of baicalin prepared can effectively improve the dissolution of baicalin in artificial gastric juice.
Guangdong Pharmaceutical University, Guangzhou 510006, China. luoxiao-qin@163.com
Xiao-Qin
XQ
Luo
Jian-Qiong
JQ
Yang
D019540:Area Under Curve; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D045703:Emulsifying Agents / Q000737:chemistry*; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D005990:Glycerol / Q000737:chemistry; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D011136:Polysorbates / Q000737:chemistry; D031363:Scutellaria / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
D002214:Capsules; D045703:Emulsifying Agents; D005419:Flavonoids; D009821:Oils; D011136:Polysorbates; D014867:Water; C038044:baicalin; D005990:Glycerol