Granulomatous mycosis fungoides with large cell transformation misdiagnosed as leprosy.
BACKGROUND
Granulomatous mycosis fungoides is an unusual histopathological variant of cutaneous T-cell lymphoma without clinical distinction from classic mycosis fungoides. Symptoms associated with peripheral nerve involvement have rarely been reported in the literature.


METHODS
The authors described a case of granulomatous MF stage IIB with large cell transformation who initially presented with leprosy-like condition and chronic left peroneal neuropathy The patient received six courses ofgemcitabine with greater than 90% improvement of skin lesions. The rest of the lesions were successfully treated with local electron beam radiation.


CONCLUSIONS
Granulomatous MF with neuropathy can be clinically misdiagnosed if there is no histopathological and immunohistochemical finding to support the diagnosis of lymphoma.
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Sujittra
S
Siriphukpong
Penvadee
P
Pattanaprichakul
Panitta
P
Sitthinamsuwan
Ekapun
E
Karoopongse
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003951:Diagnostic Errors; D018450:Disease Progression; D006099:Granuloma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007918:Leprosy / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000473:pathology; D009182:Mycosis Fungoides / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D016896:Treatment Outcome; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine