Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients.
OBJECTIVE
To evaluate the effects of short-term restriction of dietary protein intake (DPI) supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis (MHD) patients.


METHODS
Forty MHD patients with uncontrolled hyperphosphatemia were randomized to either low DPI with keto acid-supplemented (sLP) or normal DPI (NP) group for 8 weeks. After 8 weeks, the sLP group was shifted to NP for another 8 weeks. Low-protein diet (LPD) was individualized with total caloric intake 30-35 kcal/kg/day, protein intake of 0.8 g/kg/day and phosphate intake of 500 mg/day. Keto acids were supplied in a dosage of 12 pills per day. Calcium phosphorous metabolism index and nutritional index (serum albumin, total protein, somatometric measurements, 3-day diaries and Mini-Nutritional Assessment score) were recorded. C-reactive protein, CO(2) combining power and Kt/V were measured to evaluate the inflammation, metabolic acidosis and dialysis adequacy, respectively.


RESULTS
Serum phosphorus level and calcium-phosphate product were significantly decreased at the end of the first 8 weeks in the sLP group compared to the basal value and the NP group (p < 0.001). No difference was observed in C-reactive protein, Kt/V and nutritional index, while CO(2) combining power was significantly higher at week 8 in the sLP group (p < 0.001).


CONCLUSIONS
Short-term restriction of DPI supplemented with keto acids could decrease hyperphosphatemia and calcium-phosphate product, while keeping stable nutritional status among MHD patients.
Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
Haiming
H
Li
Quan
Q
Long
Chunhai
C
Shao
Hong
H
Fan
Li
L
Yuan
Bihong
B
Huang
Yong
Y
Gu
Shanyan
S
Lin
Chuanming
C
Hao
Jing
J
Chen
D002118:Calcium / Q000097:blood; D018753:Diet, Protein-Restricted / Q000379:methods*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D054559:Hyperphosphatemia / Q000178:diet therapy* / Q000209:etiology*; D007651:Keto Acids / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010710:Phosphates / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects*
D007651:Keto Acids; D010710:Phosphates; D002118:Calcium