Pulmonary manifestations of inflammatory bowel disease: case presentations and review.
Inflammatory bowel disease (IBD) is associated with a number of extraintestinal manifestations that may involve most organ systems. Extraintestinal manifestations are more common in Crohn disease (CD) and may include rheumatologic, ocular, dermatologic, biliary and pulmonary manifestations. The most common pulmonary manifestations of IBD are drug-induced lung disease. Other manifestations include parenchymal disease, pleuritis and overlap syndromes. We present a case series of 7 patients with non-infectious pulmonary manifestations of IBD, which included cryptogenic organizing pneumonia, usual interstitial pneumonitis (UIP), Langerhan's granulomatosis, and eosinophilic pneumonia. Concurrent extraintestinal manifestations present in these patients included arthralgia, iritis, and pyoderma gangrenosum. In most patients the development of pulmonary disease parallels that of the intestinal disease activity, extraintestinal manifestations and concurrent use of 5-ASA medications.
Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Benjamin
B
Basseri
Pedram
P
Enayati
Alberto
A
Marchevsky
Konstantinos A
KA
Papadakis
D000293:Adolescent; D000328:Adult; D001988:Bronchiolitis / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000188:drug therapy; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced / Q000150:complications* / Q000209:etiology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055613:Multiple Pulmonary Nodules / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D055815:Young Adult