Anticoagulation and antiplatelet effects of semax under conditions of acute and chronic immobilization stress.
The effects of semax on anticoagulant, fibrinolytic, and platelet components of the anticoagulation system were studied on albino rats under conditions of acute and chronic immobilization stress. Semax exhibited a protective antistress effect after repeated intranasal administration under conditions of hypercoagulation developing in response to immobilization stress of different degree. The effect manifested in stimulation of the anticoagulation system.
Laboratory of Defense Systems of Blood, Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow University, Russsia. mgrigorjeva@mail.ru
M E
ME
Grigorjeva
L A
LA
Lyapina
D000281:Administration, Intranasal; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001792:Blood Platelets / Q000187:drug effects*; D005342:Fibrinolysis / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000187:drug effects* / Q000502:physiology
D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone