Catalase, carbonic anhydrase and other biochemical parameters in esophageal cancers in Turkey.
OBJECTIVE
The main aim of our investigation is to show possible changes in antioxidant balance and selected biochemical parameters in esophageal cancers.


METHODS
This study was performed for the determination of levels in 25 patients diagnosed as having cancer in the Yuzuncu Yil University (Medical Oncology) and 15 healthy volunteers at same department with negative cancer signs.


RESULTS
The activity levels of catalase of sick and health groups were 33.8±4.31 (EU/gHg)-1, 122.4±31.7 (EU/gHg)-1, respectively. Th differance between the average levels was significant (p<0.001). CA (carbonic anhydrase) activity was 2.19±0.12 (EU/gHg)-1, 2.46±0.32 (EU/gHg)-1 in groups at same order with no statistical significance (p>0.05). The levels of albumin, globulin, ferritin, ALT, LDH, glucose, CRP, AST and uric acid were also determined in sick and healthy groups: 4.04±0.24, 4.04±0.43 gr/dl (p>0.05); 4.46±0.82, 3.17±0.10g/dl (p>0.05); 175.4±29.1, 260.4±15.45g/dI (p<0.001); 12.7±1.13, 19.5±1.91 ng/ml (p<0.001); 317.6±13.8, 298.0±12.1 mg/dl (p>0.05); 106.5±12.1, 89.7±2.2 (p>0.05), 5.94±1.04, 4.41±0.28 U/L (p>0.05); 19.4±1.68, 19.5±1.91 mg/dl (p>0.05); 30.0±3.24, 10.5±0.64 mg/dl (p<0.01) respectively.


CONCLUSIONS
Consequently, in diagnosis of esophageal cancer, CA, CRP, uric acid and antioxidant examinations may be very important factors. Additional studies are needed to further address this important issue.
Department of Chemistry, Faculty of Science and Art, Yuzuncu Yil University, Van, Turkey. halitdemir2005@yahoo.com
Halit
H
Demir
Zeynel Abidin
ZA
Akkus
Aysegul
A
Cebi
Tahir
T
Cakir
Mustafa
M
Izmirli
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000418:Albumins / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000097:blood; D002374:Catalase / Q000097:blood; D004938:Esophageal Neoplasms / Q000097:blood* / Q000201:enzymology; D005260:Female; D005293:Ferritins / Q000097:blood; D005916:Globulins / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D014421:Turkey; D014527:Uric Acid / Q000097:blood
D000418:Albumins; D001786:Blood Glucose; D005916:Globulins; D008077:Lipoproteins, LDL; D014527:Uric Acid; D002097:C-Reactive Protein; D005293:Ferritins; D002374:Catalase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002256:Carbonic Anhydrases