Cardiac myofilaments: from proteome to pathophysiology.
This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.
Departments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wenhai
W
Jin
Anna T
AT
Brown
Anne M
AM
Murphy