[Acute generalized exanthematous pustulosis following a spider bite: three cases from Tunisia].
BACKGROUND
acute generalized exanthematous pustulosis (AGEP) is a severe eruption induced in most cases by medication; more rarely, it is associated with viral infection, food allergens or toxins. The literature contains only very rare reports of AGEP caused by a spider bite. We describe three cases of AGEP in Tunisian women following a spider bite.


METHODS
three Tunisian women were hospitalized in the dermatology department during the summer months presenting acute febrile pustulosis and rash occurring after a spider bite. The diagnosis of AGEP was confirmed with certainty based on the EuroSCAR score. Two patients presented marked eosinophilia. The outcome was favourable in all cases after symptomatic treatment.


CONCLUSIONS
the factors militating in favour of spider-bite origin in these three patients were: (1) the presence of skin lesions characteristic of a spider bite; (2) the chronology of events, with eruption occurring 24 to 48 hours after the bite; and (3) the exclusion of the common causes of AGEP and the presence of marked eosinophilia in two of the cases.


CONCLUSIONS
Our cases and the few cases published in the literature indicate that spider bites may be added to the list of the possible causes of AGEP.
Service de Dermatologie, Hôpital Farhat Hached, Avenue Ibn El Jazzar, 4000 Sousse, Tunisie.
Z
Z
Ben Said
W
W
Saidi
L
L
Boussofara
N
N
Ghariani
C
C
Belajouza
B
B
Sriha
M
M
Denguezli
R
R
Nouira
D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000175:diagnosis*; D005260:Female; D006801:Humans; D001098:Spider Bites / Q000175:diagnosis*; D014416:Tunisia; D055815:Young Adult