The status of thrombophilic defects and non-O blood group as risk factors for gestational vascular complications among Tunisian women.
OBJECTIVE
Our objectives were to assess inherited thrombophilia and non-O blood group for the risk of gestational vascular complications among the Tunisian population.


METHODS
This study comprised 203 test subjects with adverse pregnancy outcomes including recurrent pregnancy loss, intra-uterine growth retardation, pre-eclampsia and placental abruption. Each subgroup was matched with 100 controls and analyzed separately. All patients were evaluated for factor V Leiden, factor II G20210A mutations and for non-O blood group. Protein S, protein C and antithrombin levels were determined and deficiencies noted.


RESULTS
The factor V Leiden mutation, non-O blood group and protein C deficiency had the highest incidences among patients both as a whole and in the 4 subgroups. The factor II G20210A mutation, protein S and antithrombin deficiencies were not statistically significant risk factors.


CONCLUSIONS
Our results provide evidence for a significant association between the factor V mutation and placental abruption. Furthermore, we found that this and the non-O blood group independently increased the risk for intra-uterine growth retardation in our population.
Laboratory of Molecular Biology, Department of Hematology, Military Hospital, Tunis, Tunisia. gksarrah@yahoo.fr
Sarra
S
Klai
Najiba
N
Fekih-Mrissa
Radhouen
R
Rachdi
Nasredine
N
Gritli
D000037:Abruptio Placentae / Q000209:etiology / Q000235:genetics; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001789:Blood Group Antigens / Q000097:blood*; D016022:Case-Control Studies; D005165:Factor V / Q000032:analysis; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009154:Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology / Q000209:etiology*; D020151:Protein C Deficiency / Q000150:complications; D011516:Prothrombin / Q000032:analysis / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D014416:Tunisia / Q000453:epidemiology
D015415:Biomarkers; D001789:Blood Group Antigens; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin