Recombinant human bone morphogenetic protein type 2 jaw reconstruction in patients affected by giant cell tumor.
Giant cell tumor (GCT) is a relatively common skeletal tumor. Mandibular localization of this tumor is usually treated with resection of the tumor area. Several autogenous bone-grafting techniques are available for the restoration of large continuity defects of the mandible. However, these procedures are associated with limitations involving postoperative morbidity, difficulty in ambulation (hip graft), and pain. The development of a technique of surgical reconstruction not involving autogenous bone would offer new opportunities for facial bone reconstruction, particularly of the mandible. This study aims to underline the effect of recombinant human bone morphogenetic protein type 2 (rhBMP-2) in a collagen carrier with concomitant bone grafting material in the restoration of continuity critical-size defects after GCT resection in the mandible. The rhBMP-2 was used with absorbable collagen sponge. A total dose of 4 to 8 mg of rhBMP-2 was delivered to the surgical site in concentrations of 1.5 mg/mL. The patient was followed up over a period from 6 to 18 months. Occlusal function was initially restored with conventional prosthesis. Bone formation in the surgical area could be palpated at the end of 3 to 4 months and identified radiographically at the end of 5 to 6 months. The results clearly indicated that the use of rhBMP-2 without concomitant bone grafting materials in large critical-size mandibular defects secondary to GCT produced excellent regeneration of the area, establishing the basis for the return of prosthodontic function.
Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, California 92350, USA. aherford@sd.llu.edu
Alan S
AS
Herford
Marco
M
Cicciù
D000328:Adult; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D001860:Bone Plates; D001861:Bone Regeneration / Q000187:drug effects; D016025:Bone Transplantation / Q000379:methods*; D004337:Drug Carriers; D005260:Female; D005500:Follow-Up Studies; D005781:Gelatin Sponge, Absorbable; D018212:Giant Cell Tumor of Bone / Q000601:surgery*; D006801:Humans; D019248:Jaw Fixation Techniques; D008334:Mandible / Q000187:drug effects; D008339:Mandibular Neoplasms / Q000601:surgery*; D010012:Osteogenesis / Q000187:drug effects; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D019651:Plastic Surgery Procedures; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000627:therapeutic use*
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2