Efficient and general synthesis of oxazino[4,3-a]indoles by cascade addition-cyclization reactions of (1H-indol-2-yl)methanols and vinyl sulfonium salts.
An efficient and general approach to oxazino[4,3-a]indole architectures is described. The addition-cyclization cascade of (1H-indol-2-yl)methanols with vinyl sulfonium salts affords oxazino[4,3-a]indole derivatives in high yields.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
Jing
J
An
Ning-Jie
NJ
Chang
Li-Dong
LD
Song
Yu-Qin
YQ
Jin
Ying
Y
Ma
Jia-Rong
JR
Chen
Wen-Jing
WJ
Xiao
D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D000432:Methanol / Q000737:chemistry*; D008956:Models, Chemical; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D013452:Sulfonium Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
C015146:3,4-dihydro-1H-1,4-oxazino(4,3a)indole; D007211:Indoles; D010078:Oxazines; D013452:Sulfonium Compounds; D014753:Vinyl Compounds; D000432:Methanol