Activity of some enzymes in the liver of experimental animals after treatment with the liposomal formulation of tetracycline and streptomycin.
A new method for obtaining the liposomal formulation of streptomycin and tetracycline is described in the present work. The physicochemical properties of this formulation were evaluated. We compared the effects of free and liposomal formulations from streptomycin and tetracycline on activity of liver enzymes in albino mice. Immobilization of antibiotics in liposomes was followed by a decrease in the inhibitory effect on protease, alkaline phosphatase, and phosphorylase. The influence of this preparation on ATPase was reduced by 2 times.
Volgograd Antiplague Institute, Russian Agency for Health and Consumer Rights, Russia.
S N
SN
Tikhonov
K A
KA
Rotov
V V
VV
Alekseev
E A
EA
Snatenkov
N P
NP
Khrapova
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D008081:Liposomes / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D006005:Phosphorylases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D013307:Streptomycin / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology*
D008081:Liposomes; D011480:Protease Inhibitors; D006005:Phosphorylases; D000469:Alkaline Phosphatase; D013752:Tetracycline; D013307:Streptomycin