The potential cardioprotective effects of hydrogen in irradiated mice.
Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.
Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China. qlr2007@126.com
Liren
L
Qian
Fei
F
Cao
Jianguo
J
Cui
Yicun
Y
Wang
Yuecheng
Y
Huang
Yunhai
Y
Chuai
Luqian
L
Zaho
Hao
H
Jiang
Jianming
J
Cai
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects*; D006335:Heart Injuries / Q000378:metabolism / Q000517:prevention & control; D006859:Hydrogen / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control
D000975:Antioxidants; D002316:Cardiotonic Agents; D008315:Malondialdehyde; D006859:Hydrogen; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine