Focus issue: metabolic signals.
This Focus Issue of Science Signaling complements the Science Special Issue on Metabolism (http://www.sciencemag.org/special/metabolism) by turning attention to the pathways and molecules involved in controlling cellular metabolic processes. Highlights include an unexpected role in triggering apoptosis for the insulin receptor and the related IGF-1 receptor (known for their roles in metabolism and growth), a role for lipids as cellular sensors of glucose metabolism, and a mechanism whereby cells can survive oxidative stress by shifting the activity of the cell's protein degradation complex.
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D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D017526:Receptor, IGF Type 1 / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin; D005947:Glucose