Good intentions: risk factors for unintended pregnancies in the US cohort of a microbicide trial.
BACKGROUND
The study was conducted to assess socio-behavioral and biological factors associated with unplanned pregnancy in the US cohort of a microbicide trial.


METHODS
We conducted a mixed-method, nested case-control study of risk factors for pregnancy within the US cohort of the microbicide trial HPTN 035. We developed an instrument to assess attitudes and beliefs about fertility control/contraceptive utilization among 122 women. Cases were HPTN 035 participants who became pregnant while enrolled, matched by time on study 1:4 with controls. Univariable and multivariable analysis were performed with pregnancy as the outcome of interest.


RESULTS
Contraceptive method change during the trial was associated with unplanned pregnancy (OR=1.76). Participant desire/partners' desire for future children (OR=4.95) and young age (OR=0.88 annually above age 19 years) were independently associated with unintended pregnancy.


CONCLUSIONS
Within a trial that enroll heterosexually active women, there may be ways to identify those at highest risk of becoming pregnant a priori.
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. cschreiber@obgyn.upenn.edu
Courtney A
CA
Schreiber
Sara
S
Whittington
Liyi
L
Cen
Lisa
L
Maslankowski
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D015143:Philadelphia; D011247:Pregnancy; D049168:Pregnancy, Unplanned / Q000523:psychology*; D012307:Risk Factors; D011795:Surveys and Questionnaires
D000890:Anti-Infective Agents