Ring A-seco triterpenoids with antibacterial activity from Dysoxylum hainanense.
Five new ring A-seco triterpenoids, dysoxyhainic acids F-J (1-5), along with a known ring A-seco triterpenoid koetjapic acid (6) were isolated from the twigs and leaves of Dysoxylum hainanense. Their structures were established on the basis of extensive spectroscopic analysis. Antimicrobial activity of all the compounds against fungi and bacteria were tested. Compounds 2-4 and 6 exhibited significant antimicrobial activity against Gram-positive bacteria, and the antibacterial SAR (structure-activity relationship) was also briefly discussed.
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
Xiu-Feng
XF
He
Xiao-Ning
XN
Wang
Sheng
S
Yin
Lei
L
Dong
Jian-Min
JM
Yue
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D014315:Triterpenes