Evolutionary dynamics of cancer prevention.
Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.
Departments of Radiology and Integrated Mathematical Oncology, Moffitt Cancer Center, USA. Robert.Gatenby@Moffitt.org
Robert A
RA
Gatenby
Robert J
RJ
Gillies
Joel S
JS
Brown
D005075:Biological Evolution; D002465:Cell Movement; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D004848:Epithelium / Q000276:immunology*; D056084:Genetic Fitness; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000473:pathology / Q000517:prevention & control*; D013234:Stem Cells / Q000502:physiology