Remotely nano-rupturable yolk/shell capsules for magnetically-triggered drug release.
Yolk/shell capsules containing a volume/hydrophobicity transformable core and an ultra-thin silica shell have been prepared. When an external magnetic field induced the temperature, the cores exhibit a significant triggering size shrinkage and the diameter decreases more than 10 times, causing solid shells destruction and physical collapse, leading to drug burst release.
Department of Materials Sciences and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan.
Shang-Hsiu
SH
Hu
You-Yin
YY
Chen
Ta-Chung
TC
Liu
Tsan-Hua
TH
Tung
Dean-Mo
DM
Liu
San-Yuan
SY
Chen
D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000032:analysis* / Q000737:chemistry; D055590:Electromagnetic Phenomena; D005290:Ferric Compounds / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000008:administration & dosage / Q000032:analysis* / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013696:Temperature
D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; D053769:Nanocapsules; C000499:ferric oxide; D012822:Silicon Dioxide