Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential.
H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversial, H2S, through its anti-apoptotic, anti-inflammatory and antioxidant effects, has demonstrated significant cardioprotection. As a result, a number of sulfide-donor drugs, including garlic-derived polysulfides, are currently being designed and investigated for the treatment of cardiovascular conditions, specifically myocardial ischaemic disease. However, huge gaps remain in our knowledge about this gasotransmitter. Only by additional studies will we understand more about the role of this intriguing molecule in the treatment of cardiovascular disease.
Department of Surgery, The Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, USA.
Madhav
M
Lavu
Shashi
S
Bhushan
David J
DJ
Lefer
D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000517:prevention & control; D002319:Cardiovascular System / Q000378:metabolism*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism* / Q000627:therapeutic use; D007249:Inflammation / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D018384:Oxidative Stress / Q000502:physiology
D002316:Cardiotonic Agents; D006862:Hydrogen Sulfide