Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage.
Sodium nitrite (NaNO(2)) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10 ml/kg infusions of either HBOC-201 or Hextend with and without NaNO(2). All vital signs, coagulation and blood chemistry were measured for 2 hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 μmol/kg NaNO(2) infusion. Complete abolition was obtained with the highest 3 NaNO(2) dose, but side effects were observed. There was no reduction in platelet function due to NaNO(2). NaNO(2) ability to reduce HBOC-201 vasoactivity was transient and 10.8 μmol/kg NaNO(2) seems an acceptable dose for further investigation.
Naval Medical Research Center, Operational and Undersea Medicine, NeuroTrauma Department, Silver Spring, MD 20910-7500, USA. Francoise.arnaud@med.navy.mil
Françoise
F
Arnaud
Anke H
AH
Scultetus
Bobby
B
Kim
Ashraful
A
Haque
Biswajit
B
Saha
Savita
S
Nigam
Paula
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Moon-Massat
Charles
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Auker
Richard
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McCarron
Daniel
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Freilich
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001808:Blood Vessels / Q000187:drug effects* / Q000503:physiopathology*; D001810:Blood Volume / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006454:Hemoglobins / Q000008:administration & dosage / Q000494:pharmacology*; D006470:Hemorrhage / Q000503:physiopathology*; D006487:Hemostasis / Q000187:drug effects; D012151:Resuscitation; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000494:pharmacology*; D013552:Swine; D055986:Vital Signs / Q000187:drug effects
D006454:Hemoglobins; C096798:HBOC 201; D012977:Sodium Nitrite