Acute hepatitis due to hepatitis E virus genotype 1 as an imported infectious disease in Japan.
An 18-year-old Nepalese man was admitted due to general malaise and anorexia a month after coming to Japan. Laboratory tests showed elevation of transaminase and positivity for IgM anti-HEV antibody. Serum HEV RNA was detected by RT-PCR amplifications. An HEV genome phylogenetic tree, constructed using an 821-nucleotide sequence in the open reading frame 1, indicated that the genotype was 1. HEV genotype 1 is epidemic in South Asia, Africa and South America, and the incidence of acute hepatitis due to HEV genotype 1 is low in Japan. Thereafter, attention should be paid to HEV genotype 1 infection as an imported infectious disease.
Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences.
Koji
K
Miyahara
Yasuhiro
Y
Miyake
Tetsuya
T
Yasunaka
Fusao
F
Ikeda
Akinobu
A
Takaki
Yoshiaki
Y
Iwasaki
Haruhiko
H
Kobashi
Jong-Hon
JH
Kang
Kazuaki
K
Takahashi
Masahiro
M
Arai
Kazuhide
K
Yamamoto
D000208:Acute Disease; D000293:Adolescent; D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000235:genetics / Q000821:virology*; D005838:Genotype; D016751:Hepatitis E / Q000175:diagnosis* / Q000453:epidemiology* / Q000821:virology; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D010802:Phylogeny