[Surface-active agents from the group of polyoxyethylated glycerol esters of fatty acids. Part I. Basic thermodynamics values of a structure, and the level of hydrophilic/lipophilic balance (HLB) of the oxyethylenation products of Lard's fractions (Adeps suillus FP VI)].
Research was conducted into the properties and identity of the oxyethylenation products of triglycerides derived from Lard (Adeps suillus) using original, stereoselective catalyst K-4. Determined of drop-point temperature -Tk (273.15 + t degrees C) allowed for calculation coefficients of volumetric dilatability--alpha (v0), linear dilatability--alpha(l0) as well as structural viscosity of the product (eta) in the state of equilibrium liquefaction. The solubility parameter delta(1/2) and the required numerical value of HLB(R )were calculated for oxyethylated product's fractions. The number of oxyethylated segments -n(TE) was determined by 1HNMR method, it made possible to estimate the weight-average molecular mass Mw, and also structural (m. Griffin) and analitycal (m. 1HNMR) level of hydrophilic/lipophilic balance--HLB. The results obtained in the course of research served as a basis for determine application properties of oxyethylated products of triglycerides fractions, in particular for the purpose of examination them for using as a transdermal passage promotors and micellar solubilizers for lipophilic therapeutic agents belonging to BCS Class II and III.
Pracownia Leku Cytotoksycznego Wojewódzkiego Szpitala Specjalistycznego im. M. Kopernika w Łodzi.
Jowita Barbara
JB
Piotrowska
Michał Jakub
MJ
Nachajski
Marek
M
Lukosek
Marian Mikołaj
MM
Zgoda
D000818:Animals; D004041:Dietary Fats / Q000032:analysis*; D004655:Emulsions / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008956:Models, Chemical; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D013552:Swine; D013816:Thermodynamics; D014280:Triglycerides / Q000737:chemistry*; D014783:Viscosity
D004041:Dietary Fats; D004655:Emulsions; D004952:Esters; D005227:Fatty Acids; D013501:Surface-Active Agents; D014280:Triglycerides; D005990:Glycerol; C029310:lard