Core/shell nanoparticles for pH-sensitive delivery of doxorubicin.
Core/shell nanoparticles with lipid core were prepared and characterized as pH-sensitive delivery system of anticancer drug. The lipid core is composed of drug-loaded lecithin and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) tri-block copolymer, F-127). Based on the preparation method in the previous report by us, the freeze-drying of drug-loaded lecithin was performed in the F-127 aqueous solution containing trehalose used as a cryoprotectant to form stabilized core/shell nanoparticles. For the application of core/shell nanoparticles as a pH-sensitive drug delivery system for anticancer drug, doxorubicin was loaded into the core/shell nanoparticles and the drug loading amount and drug release behavior in response to pH change were observed.
Department of Advanced Materials, Hannam University, Daejeon 305-811, Korea.
Keun Sang
KS
Oh
Yun Sik
YS
Um
Jin Ho
JH
Lee
Sun Hang
SH
Cho
Kyung Eun
KE
Lee
Sung Sik
SS
Han
Dongmin
D
Kim
Soon Hong
SH
Yuk
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D054709:Lecithins / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry; D014199:Trehalose / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D054709:Lecithins; D020442:Poloxamer; D004317:Doxorubicin; D014199:Trehalose