[Lipoma of the uterus: clinical and ethiopathological approach of 7 cases with immunohistochemical study of histogenesis].
BACKGROUND
Lipoleiomyoma of the uterus (LLU) is an extremely rare, benign, uterine tumour. This rare disease was unknown for a long time. Their histogenesis remains controversial.


OBJECTIVE
To describe the clinical and pathological aspects of uterine lipoleiomyoma and to try to specify, by an immunohistochemical study, its degenerative or tumoral nature.


METHODS
7 cases of LLU were identified represented by 2 pure Lipoma and 5 Lipoleiomyoma. We performed an immunohistochemical study including anti-vimentin, anti-smooth muscle actin, anti PS-100, anti-desmin, anti-factor VIII and anti-HMB- 45. The results were correlated with the pathogenesis of this lesion.


RESULTS
Immunohistochemical analysis showed an expression of PS 100 only in lipocytes whereas leiomyomatous cells express only smooth muscle actin.


CONCLUSIONS
Our study supports the benign tumoral nature of the fatty uterine lesions. Lipoleiomyomatous cells may originate from the transformation of a totipotent mesenchymal cell and not from a degenerative process.
Laboratoire d'anatomie pathologique de l'Hôpital Mongi Slim La Marsa, Tunis, Tunisia.
Olfa
O
El Amine El Hadj
Saadia
S
Bouraoui
Carole Goutallier
CG
Ben Fadhel
Ahlem
A
Lahmar
Sabeh
S
Mzabi-Regaya
D000199:Actins / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D012189:Retrospective Studies; D009418:S100 Proteins / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D000199:Actins; D009418:S100 Proteins