Effect of peptide bioregulator on healing of excision wounds in old animals.
Aging is associated with reduction of protein synthesis in cells, which leads to deceleration of proliferative processes in various tissues. Recovery of damaged skin sites was stimulated with a peptide bioregulator chondrolux. This agent is based on an extract from calf cartilage and bone tissue. Its effect on healing of excision wounds was studied in old rabbits. Morphological analysis of the wound surface during various periods of healing was carried out by electron microscopy. The results indicate that chondrolux application to the wound surface stimulated and optimized the reparative process. Active development of granulation tissue was observed as early as on day 14 after wound infliction (vs. days 21-28 in control animals). Acceleration of wound healing was paralleled by an increase in functional activities of fibroblast organelles.
Chelyabinsk Institute of Laser Surgery, Russian Academy of Medical Sciences, Russia.
I N
IN
Kurilov
G A
GA
Ryzhak
D000818:Animals; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000293:injuries; D014945:Wound Healing / Q000187:drug effects*
D010455:Peptides