Resveratrol protects against a model of vacuous chewing movements induced by reserpine in mice.
Reserpine treatment is a putative animal model of orofacial dyskinesia, tremor, and Parkinsonism. Here, we examined the effects of resveratrol, a polyphenol with neuroprotective properties primarily contained in red grapes and red wine, in an animal model of vacuous chewing movements (VCMs) induced by treatment with reserpine. Mice were treated with reserpine (1 mg/kg, subcutaneously on days 1 and 3) and/or resveratrol (5 mg/kg, intraperitoneally 3 consecutive days). VCM, locomotor, and exploratory performance were evaluated. Reserpine treatment produced an increase in VCM intensity, which was significantly reduced by resveratrol co-treatment. Reserpine also decreased locomotor and exploratory activity in the open field test. However, resveratrol co-treatment was not able to protect against these effects. The data suggest that resveratrol could be a promising pharmacological tool for studying VCM in rodents. However, further investigations are needed to understand the exact mechanisms involved in the neuroprotective effects of resveratrol.
Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, RS, Brazil.
Alcindo
A
Busanello
Nilda Berenice Vargas
NB
Barbosa
Luis Ricardo
LR
Peroza
Luana Echeverria
LE
Farias
Marilise Escobar
ME
Burger
Katia Padilha
KP
Barreto
Roselei
R
Fachinetto
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D008409:Mastication / Q000187:drug effects*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D013267:Stilbenes; D012110:Reserpine; D000077185:Resveratrol