Intracerebral administration of brain-derived neurotrophic factor (BDNF) reduces severity of cataleptic freezing in mice with genetic predisposition to catalepsy.
Single administration of brain-derived neurotrophic factor (BDNF) into the lateral ventricle of ASC mice (Antidepressant Sensitive Catalepsy), a model of depression-like state, significantly decreased predisposition to cataleptic freezing in these animals. These findings indicate that BDNF can appear as a promising antidepressant of new generation and that ASC mice can be used as an adequate model for investigations of the mechanisms of behavior modification by BDNF.
Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. maratikh@mail.ru
M A
MA
Tikhonova
A V
AV
Kulikov
V S
VS
Naumenko
M V
MV
Morozova
D V
DV
Bazovkina
N K
NK
Popova
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D019208:Brain-Derived Neurotrophic Factor / Q000648:ultrastructure*; D002375:Catalepsy / Q000188:drug therapy*; D008297:Male; D051379:Mice
D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor