Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives.
A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.
Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
Yu
Y
Luo
Feng
F
Xiao
Shijing
S
Qian
Wei
W
Lu
Bo
B
Yang
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001562:Benzimidazoles