Ultrasound-promoted synthesis of 3-trichloromethyl-5-alkyl(aryl)-1,2,4-oxadiazoles.
The alternative synthesis of 12 1,2,4-oxadiazoles using ultrasound irradiation from trichloroacetoamidoxime and acyl chlorides is reported. Seven of them are novel compounds. The 3-trichloromethyl-5alkyl(aryl)-1,2,4-oxadiazoles have been synthesised in better yields and shorter reaction times compared to the conventional method. This protocol can be applicable for preparation of 1,2,4-oxadiazoles containing aryl or alkyl groups attached at their C-5 side-chain.
NuQuiA-Núcleo de Química Aplicada, Departamento de Química Orgânica, Universidade Federal de Pelotas, Brazil.
Lizandra C
LC
Bretanha
Vinicius E
VE
Teixeira
Marina
M
Ritter
Geonir M
GM
Siqueira
Wilson
W
Cunico
Claudio M P
CM
Pereira
Rogério A
RA
Freitag
D007700:Kinetics; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D014465:Ultrasonics
D010069:Oxadiazoles