SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model.
Ageing in mammals remains an unsolved mystery. Anti-ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti-ageing and anti-senescence activity of SIRT1 have been discussed. In particular, a counter-balancing model involving the cross-talks between SIRT1 and AMP-activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian cells.
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China. yuwanghk@hku.hk
Yu
Y
Wang
Yan
Y
Liang
Paul M
PM
Vanhoutte
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D016922:Cellular Senescence; D006801:Humans; D008954:Models, Biological; D020239:Receptor Cross-Talk; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000378:metabolism*
D055372:AMP-Activated Protein Kinases; D056564:Sirtuin 1