Antiretroviral activity of thiosemicarbazone metal complexes.
Thiosemicarbazones display a wide antimicrobial activity by targeting bacteria, fungi, and viruses. Here, we report our studies on the antiviral activity of two thiosemicarbazone metal complexes, [bis(citronellalthiosemicarbazonato)nickel(II)] and [aqua(pyridoxalthiosemicarbazonato)copper(II)] chloride monohydrate, against the retroviruses HIV-1 and HTLV-1/-2. Both compounds exhibit antiviral properties against HIV but not against HTLVs . In particular, the copper complex shows the most potent anti-HIV activity by acting at the post-entry steps of the viral cycle.
Dipartimento di Chimica GIAF, Università di Parma, Viale G.P. Usberti 17A, 43124 Parma, Italy.
Giorgio
G
Pelosi
Franco
F
Bisceglie
Fabio
F
Bignami
Paola
P
Ronzi
Pasqualina
P
Schiavone
Maria Carla
MC
Re
Claudio
C
Casoli
Elisabetta
E
Pilotti
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D044966:Anti-Retroviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000502:physiology; D015367:Human T-lymphotropic virus 2 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000821:virology; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053586:Virus Internalization; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents; D056831:Coordination Complexes; D013882:Thiosemicarbazones; C555229:aqua(pyridoxalthiosemicarbazonato)copper(II); C555228:bis(citronellalthiosemicarbazonato)nickel(II)