[Relationship between the absolute lymphocyte count before or after autologous hematopoietic stem cell transplantation and the prognosis in patients with non-Hodgkin's lymphoma].
OBJECTIVE
To evaluate the relationship of the absolute lymphocyte count (ALC) before or after autologous hematopoietic stem cell transplantation (AHSCT), and the infused CD34(+) count with the relapse, disease-free survival (DFS), overall survival (OS) in non-Hodgkin's lymphoma (NHL) patients.


METHODS
A retrospective analysis of the relationship of the absolute lymphocyte count before (ALC-Pro) or 15 days after (ALC-15) the AHSCT, and the infused CD34(+) cell count with the relapse, DFS, OS of NHL.


RESULTS
ALC-Pro and ALC-15 were related to NHL relapse. The patients with high levels of ALC-Pro and ALC-15 had lower relapse rate. By Kaplan-Meier curve and COX multi-variable regression analysis, it was found that both ALC-Pro and ALC-15 were factors associated with the DFS. Patients infused high levels of CD34(+) cells had longer DFS. Patients with high levels of ALC-Pro, ALC-15, CD34(+) counts had longer OS.


CONCLUSIONS
ALC-Pro, ALC-15 and CD34(+) counts were significant in predicting relapse, DFS and OS for patients with NHL.
Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Jie
J
Chen
Jian-Min
JM
Wang
Wei-Ping
WP
Zhang
Xian-Min
XM
Song
Hui-Ying
HY
Qiu
Xiao-Qian
XQ
Xu
Hong
H
Zhou
Li
L
Chen
D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D018655:Lymphocyte Count; D008228:Lymphoma, Non-Hodgkin; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies