Effect of hydrophobic octadecyl groups on pH-sensitive aggregation behavior of imidazole-containing polyaspartammide derivatives.
The effect of hydrophobic octadecyl groups on pH-dependent aggregation behavior of polyaspartammide derivatives was studied. A series of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution were synthesized through a successive graft reaction of octaceylamine, O-(2-aminoethyl)-O'-methylpolyethylene glycol, and 1-(3-aminopropyl)imidazole on polysuccinimide. Micelle-like nano-aggregates were formed in aqueous solution at pH > 6.8 and they showed different pH dependent aggregation behavior according to degree of substitution (DS) of the hydrophobic C18 chains. These polymers will have a potential application as carriers for pH-sensitive drug release in anticancer or intracellular delivery systems.
Department of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Korea.
Kwangwon
K
Seo
Doo Sung
DS
Lee
Sung Chul
SC
Kim
Dukjoon
D
Kim
D000588:Amines / Q000737:chemistry; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007093:Imidazoles / Q000737:chemistry*; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*
C515394:1-(3-aminopropyl)imidazole; D000588:Amines; D007093:Imidazoles; D008823:Micelles; D010455:Peptides; D020005:Propanols; C017645:polyaspartate; D011092:Polyethylene Glycols; C009317:stearylamine