Derivatization of 2-chlorophenol with 4-amino-anti-pyrine: a novel method for improving the selectivity of molecularly imprinted solid phase extraction of 2-chlorophenol from water.
Molecularly imprinted polymer (MIP) may not selectively recognize small template of limited number of functional groups, such as 2-chlorophenol (2-CP). In this work, a novel method was proposed to improve the recognition ability of the molecularly imprinted solid phase extraction (MISPE) of 2-CP from environmental waters. This was achieved by derivatization of 2-CP with 4-amino-anti-pyrine (4-AAP) to enlarge its molecular size and add more binding sites. For that purpose, two MISPE methods of 2-CP were developed. In method 1, a polymer imprinted with 2-CP was used as the extracting sorbent but it suffered from low selectivity and high detection limit of 2-CP (7.10 ng L(-1)). In method 2, a polymer imprinted with 4-AAP derivatized 2-CP (2-CP-4-AAP) was used as the extracting sorbent. Prior to loading the water sample it was subjected to a simple derivatization procedure with 4-AAP. Method 2 showed high recognition ability/selectivity towards 2-CP-4-AAP with lower detection limit of 0.05 ng L(-1) for 2-CP-4-AAP. Method 2 was able to detect the presence of 2-CP-4-AAP in unspiked real water samples and almost full spike recovery was achieved.
Department of Chemistry, Faculty of Science, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan. amjadelsheikh3@yahoo.com
Amjad H
AH
El-Sheikh
Rasha W
RW
Al-Quse
Musa I
MI
El-Barghouthi
Fida'a S
FS
Al-Masri
D000327:Adsorption; D000675:Ampyrone / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical; D002733:Chlorophenols / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004784:Environmental Monitoring / Q000379:methods; D008956:Models, Chemical; D019800:Phenol / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis; D018508:Water Purification
D002733:Chlorophenols; D010636:Phenols; D011108:Polymers; D011721:Pyrenes; D014874:Water Pollutants, Chemical; D014867:Water; D000675:Ampyrone; D019800:Phenol; C030683:2-chlorophenol