Decreased concentrations of pigment epithelium-derived factor in peritoneal fluid of patients with endometriosis.
To determine whether patients with endometriosis have altered levels of pigment epithelium-derived factor (PEDF) in peritoneal fluid, concentrations of PEDF in peritoneal fluid collected from 42 patients with endometriosis and 30 patients without endometriosis were measured with enzyme-linked immunosorbent assay. We detected significantly lower levels of peritoneal fluid PEDF in patients with endometriosis compared with patients without endometriosis, suggesting that peritoneal fluid PEDF plays a role in the pathogenesis of this disorder.
Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Liqing
L
Chen
Ruijia
R
Fan
Xiufeng
X
Huang
Hong
H
Xu
Xinmei
X
Zhang
D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D005136:Eye Proteins / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D009414:Nerve Growth Factors / Q000032:analysis* / Q000378:metabolism; D009994:Osmolar Concentration; D010532:Peritoneal Diseases / Q000378:metabolism* / Q000473:pathology; D015843:Serpins / Q000032:analysis* / Q000378:metabolism; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor