title: Rho GTPases and exocytosis: what are the molecular links?
abstract: Delivery of proteins or lipids to the plasma membrane or into the extracellular space occurs through exocytosis, a process that requires tethering, docking, priming and fusion of vesicles, as well as F-actin rearrangements in response to specific extracellular cues. GTPases of the Rho family have been implicated as important regulators of exocytosis, but how Rho proteins control this process is an open question. In this review, we focus on molecular connections that drive Rho-dependent exocytosis in polarized and regulated exocytosis. Specifically, we present data showing that Rho proteins interaction with the exocyst complex and IQGAP mediates polarized exocytosis, whereas interaction with actin-binding proteins like N-WASP mediates regulated exocytosis.
authors.affiliation: CNRS UPR 3212, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Strasbourg, France. ory@inci-cnrs.unistra.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ory
authors.forename: Stéphane
authors.initials: S
authors.lastname: Gasman
mesh_terms: D000818:Animals; D005089:Exocytosis; D055099:Neuroendocrine Cells / Q000378:metabolism; D011485:Protein Binding; D020703:ras GTPase-Activating Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020703:ras GTPase-Activating Proteins; D020741:rho GTP-Binding Proteins