title: Effects of selective head cooling on cerebral blood flow and metabolism in newborn piglets after hypoxia-ischemia.
abstract: OBJECTIVE
  the effect of selective head cooling on cerebral blood flow (CBF) and cerebral metabolism rate (CMR) was investigated in newborn piglets.
  
  
  METHODS
  seven days old newborn piglets were randomly assigned to one of the following three groups: Selective head cooling in normal piglets (n=4), selective head cooling after HI (n=6) and normal temperature after HI (n=6). CBF was measured with color microspheres. Cerebral oxygenation metabolism rate (CMRO(2)), Cerebral glucose consumption (CMR(Glu)) and Cerebral lactate production (CMR(lac)) were calculated.
  
  
  RESULTS
  in normal piglets, CBF, CMRO(2) and CMR(glu) were significantly decreased at both 35°C (P<0.05) and 32°C (P<0.01), while CMR(lac) did not change. Compared to baseline, CBF and CMRO(2) were significantly reduced (P<0.05), while CMR(glu) and CMR(lac) were significantly increased (P<0.01), AVDO(2) was decreased (P<0.05), while AVD(glu) and AVD(lac) were significantly increased (P<0.01 respectively) in HI piglets with normal temperature respectively. Compared to normal temperature after HI, selective head cooling after HI significantly reduced CMR(glu) and CMR(lac), and AVDO(2), AVD(glu), AVD(lac) were improved at 35°C.
  
  
  CONCLUSIONS
  selective head cooling not only reduced energy consumption, but also improve brain oxygen metabolism in newborn after HI.
authors.affiliation: Department of Neonatology, Children's Hospital of Fudan University, Shanghai 201102, China. gqchengcm@yahoo.com.cn
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Cheng
authors.forename: Jinqiao
authors.initials: J
authors.lastname: Sun
authors.forename: Laishuan
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Shao
authors.forename: Wenhao
authors.initials: W
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001481:Basal Metabolism / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D002536:Cerebral Arteries / Q000737:chemistry / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply* / Q000378:metabolism*; D003080:Cold Temperature; D004195:Disease Models, Animal; D005947:Glucose / Q000032:analysis / Q000378:metabolism; D006257:Head; D007036:Hypothermia, Induced / Q000379:methods / Q000662:veterinary; D020925:Hypoxia-Ischemia, Brain / Q000151:congenital / Q000378:metabolism / Q000628:therapy* / Q000662:veterinary; D019344:Lactic Acid / Q000032:analysis / Q000378:metabolism; D010100:Oxygen / Q000032:analysis / Q000378:metabolism; D011897:Random Allocation; D012039:Regional Blood Flow / Q000502:physiology; D013552:Swine
chemical_list: D019344:Lactic Acid; D005947:Glucose; D010100:Oxygen