title: Synthesis and isolation of 5,6-dihydro-4H-1,3-oxazine hydrobromides by autocyclization of N-(3-bromopropyl)amides.
abstract: 5,6-Dihydro-4H-1,3-oxazine hydrobromides have been synthesized by the nucleophilic autocyclo-O-alkylation of N-(3-bromopropyl)amides under neutral conditions in chloroform. It is found that electron-donating amide α-substituents influence the autocyclization efficiency.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore, India 560012.
authors.forename: Damodara N
authors.initials: DN
authors.lastname: Reddy
authors.forename: Erode N
authors.initials: EN
authors.lastname: Prabhakaran
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D003500:Cyclization; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C557996:5,6-dihydro-4H-1,3-oxazine hydrobromide; D000577:Amides; D010078:Oxazines