title: [Inhibitory effects of nitric oxide and atrial natriuretic peptide on the increase in renal afferent nerve activity induced by intrarenal arterial injection of ET-1 in anesthetized rats].
abstract: OBJECTIVE
  By using electrophysiological technique, the effects of nitric oxide (NO) and atrial natriuretic peptide (ANP) on renal afferent nerve activity (RANA) induced by intrarenal arterial injection of endothelin-1(ET-1) were examined in anesthetized rat.
  
  
  RESULTS
  (1) In response to intrarenal arterial injection of ET-1 (1 microg/kg) MAP was initially decreased and subsequently increased, and RANA was increased to 208.33 +/- 16.60% (P < 0.001). (2) Pretreatment with L-Arg or ANP could effectively inhibit the above biological actions induced by ET-1.
  
  
  CONCLUSIONS
  Intrarenal arterial injection of ET-1 can markedly induce the increase in RANA, an effect which is abolished by L-arg or ANP administered by the same route.
authors.affiliation: Hebei Academy of Medical Sciences, Shijiazhuang 050021.
authors.forename: X H
authors.initials: XH
authors.lastname: Xia
authors.forename: R R
authors.initials: RR
authors.lastname: He
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D019332:Endothelin-1 / Q000494:pharmacology*; D007668:Kidney / Q000294:innervation*; D008297:Male; D009569:Nitric Oxide / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019332:Endothelin-1; D009569:Nitric Oxide; D009320:Atrial Natriuretic Factor