title: A preliminary result of treatment of neuromyelitis optica with autologous peripheral hematopoietic stem cell transplantation.
abstract: Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline. The MRI abnormalities on T1WI and T2WI improved. The postpartum maternal blood helper T (CD3+CD4+ T cell) and the CD4+/CD8+ ratio were decreased, and the cytotoxic T (CD3+CD8+ T) cell increased. This shows that APHSCT in this patient with neuromyelitis optica appears to reduce the frequency of attacks with improvement in disability. However, a larger study with more patients and a longer follow-up would be required to assess the encouraging preliminary results.
authors.affiliation: Department of Neurology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Fuhua
authors.initials: F
authors.lastname: Peng
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
authors.forename: Renwei
authors.initials: R
authors.lastname: Huang
authors.forename: Dongjun
authors.initials: D
authors.lastname: Lin
authors.forename: Jian
authors.initials: J
authors.lastname: Bao
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Lianfang
authors.initials: L
authors.lastname: Bian
mesh_terms: D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009471:Neuromyelitis Optica / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult