title: Comparison of vinorelbine-Cisplatin with gemcitabine-Cisplatin in patients with advanced non-small cell lung cancer.
abstract: OBJECTIVE
  The objective of this trial was to compare cisplatin-plus-vinorelbine regimen with cisplatin-plus-gemcitabine regimen in patients with stage IIIB-IV non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Chemonaive patients with stage IIIB-IV NSCLC received either vinoelbine 30 mg/m(2) (days 1 and 8) plus cisplatin 80 mg/m(2) (day 1) every 21 days (VC arm) or gemcitabine 1250 mg/m(2) (days 1 and 8) plus cisplatin 80 mg/m(2) (day 1) every 21 days (GC arm).
  
  
  RESULTS
  One hundred thirtyfour patients (67 VC and 67 GC) were included to the study. Overall response rates for the VC arm (31.2%) were not significantly different from that of the GC arm (34.3%). There were no differences in overall survival and one-year survival rates. Median survival and one-year survival rates for the VC and GC groups were 10.6 and 11.5 months, 45% and 46.8%, respectively. Grade 3-4 thrombocytopenia was significantly higher on the GC arm (VC 1.4% v GC 8.9%, p < 0.05), as was febrile neutropenia on the VC arm (VC 8.9% v GC 1.4%, p < 0.05).
  
  
  CONCLUSIONS
  VC and GC demonstrated similar efficacy but there were differences in toxicity profiles.
authors.affiliation: Specialist.
authors.forename: Sevket
authors.initials: S
authors.lastname: Ozkaya
authors.forename: Serhat
authors.initials: S
authors.lastname: Findik
authors.forename: Oguz
authors.initials: O
authors.lastname: Uzun
authors.forename: Atilla Guven
authors.initials: AG
authors.lastname: Atici
authors.forename: Levent
authors.initials: L
authors.lastname: Erkan