title: Aurora B: a new prognostic marker and therapeutic target in cancer.
abstract: Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.
authors.affiliation: Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, via Pansini, 5 (80131) Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Portella
authors.forename: C
authors.initials: C
authors.lastname: Passaro
authors.forename: P
authors.initials: P
authors.lastname: Chieffi
mesh_terms: D064107:Aurora Kinase B; D064127:Aurora Kinases; D014408:Biomarkers, Tumor / Q000378:metabolism; D020090:Chromosome Segregation; D048749:Cytokinesis; D006801:Humans; D008938:Mitosis; D009369:Neoplasms / Q000188:drug therapy* / Q000209:etiology; D011379:Prognosis; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000502:physiology*
chemical_list: D014408:Biomarkers, Tumor; D047428:Protein Kinase Inhibitors; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases