title: Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1.
abstract: Asthma is a chronic immune inflammatory disease characterized by variable airflow obstruction. The present study was undertaken to assess the effects of an Angelica dahurica Bentham et Hooker ethanolic extract (AD) on airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Mice that received AD displayed significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E, compared with OVA-induced mice. In our experiments, AD treatment reduced airway inflammation and suppressed oxidative stress in the OVA-induced asthma model, partly via induction of heme oxygenase (HO)-1. The effects of AD on OVA-induced HO-1 induction were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP). Our results clearly indicate that AD is a suppressor of airway allergic inflammation, and may thus be effectively used as an anti-inflammatory drug in the treatment of asthma.
authors.affiliation: Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Exporo 483, Yuseong-gu, Daejeon 305-811, Republic of Korea.
authors.forename: Mee-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Jin-Ah
authors.initials: JA
authors.lastname: Lee
authors.forename: Nam-Hun
authors.initials: NH
authors.lastname: Lee
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Heykyung
authors.initials: H
authors.lastname: Ha
authors.forename: Ming-Shan
authors.initials: MS
authors.lastname: Zheng
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Hyeun-Kyoo
authors.initials: HK
authors.lastname: Shin
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D007249:Inflammation / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D014132:Trachea / Q000473:pathology*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D018927:Anti-Asthmatic Agents; D010936:Plant Extracts; D006419:Heme Oxygenase (Decyclizing)