title: Inhibin B and anti-Müllerian hormone as markers of gonadal function after treatment for medulloblastoma or posterior fossa ependymoma during childhood.
abstract: OBJECTIVE
  To evaluate the roles of hypothalamic-pituitary and spinal irradiations and chemotherapy in gonadal deficiency after treatment for medulloblastoma or posterior fossa ependymoma by measuring levels of plasma inhibin B and antimüllerian hormone (AMH).
  
  
  METHODS
  A total of 34 boys and 22 girls were classified as having normal levels of plasma follicle-stimulating hormone (FSH; <9 IU/L), or abnormal levels of FSH (>9 IU/L) and luteinizing hormone (LH; <5 or >5 IUL).
  
  
  RESULTS
  Two boys had partial gonadotropin deficiency, combined with testicular deficiency in one boy. Six boys had increased levels of FSH, indicating tubular deficiency, combined with Leydig cell deficiency in 5 boys. The 7 boys with inhibin B levels <100 ng/mL included the one with combined deficiencies and the 6 with testicular deficiency. Puberty did not progress in 7 girls; 3 had gonadotropin deficiency, combined with ovarian deficiency in one, and 4 had increased FSH levels, indicating ovarian deficiency. Inhibin B and AMH levels were low in the girl with combined deficiencies, in the 4 girls with ovarian deficiency, and in 4 girls with normal clinical-biological ovarian function, including 2 who underwent ovarian transposition before irradiation.
  
  
  CONCLUSIONS
  The plasma concentrations of inhibin B and AMH are useful means of detecting primary gonad deficiency in patients with no increase in their plasma gonadotropin levels because of radiation-induced gonadotropin deficiency.
authors.affiliation: Université Paris Descartes and AP-HP, Hôpital Bicêtre, Unité d'endocrinologie pédiatrique, Le Kremlin Bicêtre, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Cuny
authors.forename: Christine
authors.initials: C
authors.lastname: Trivin
authors.forename: Sylvie
authors.initials: S
authors.lastname: Brailly-Tabard
authors.forename: Luis
authors.initials: L
authors.lastname: Adan
authors.forename: Michel
authors.initials: M
authors.lastname: Zerah
authors.forename: Christian
authors.initials: C
authors.lastname: Sainte-Rose
authors.forename: Claire
authors.initials: C
authors.lastname: Alapetite
authors.forename: Laurence
authors.initials: L
authors.lastname: Brugières
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Habrand
authors.forename: François
authors.initials: F
authors.lastname: Doz
authors.forename: Raja
authors.initials: R
authors.lastname: Brauner
mesh_terms: D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000150:complications / Q000628:therapy*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006058:Gonadal Disorders / Q000209:etiology; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006066:Gonads / Q000378:metabolism*; D006801:Humans; D007223:Infant; D015192:Infratentorial Neoplasms / Q000150:complications / Q000628:therapy*; D007265:Inhibins / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008527:Medulloblastoma / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: C422364:inhibin B; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone