title: [Incidence and risk factors of HIV infection among sero-negative spouses of HIV patients in Dehong prefecture of Yunnan province].
abstract: OBJECTIVE
  To study the HIV incidence and risk factors among sero-negative spouses of HIV patients in Dehong prefecture of Yunnan province.
  
  
  METHODS
  A cohort of sero-negative spouses of the HIV patients had been developed and followed up since November, 2005. HIV new infections and related behaviors had been investigated every six months.
  
  
  RESULTS
  By the end of June, 2008, 790 sero-negative spouses of HIV patients had been recruited, of whom 702 were followed-up for at least one time. During the total 1202.35 person-years, 31 new HIV infections were identified, with an overall incidence of 2.58/100 person-years. The HIV incidence rates were 2.22/100 person-years in 2006, 2.95/100 person-years in 2007 and 2.74/100 person-years in 2008. Data from the Cox proportional hazard regression model indicated that those who resided in Yingjiang county [hazard ratio (HR) = 4.37, 95%CI: 1.48 - 12.90, P = 0.008], ever using drugs (HR = 3.49, 95%CI: 1.09 - 11.18, P = 0.035), or having an HIV-infected spouse who never exposed to antiretroviral treatment (HR = 3.60, 95%CI: 1.41 - 9.16, P = 0.007) were at higher risk for HIV infection.
  
  
  CONCLUSIONS
  Sero-negative spouses of HIV patients in Dehong prefecture of Yunnan province had a relatively high incidence of HIV new infection during 2006-2008. More efforts should put on those people living in these areas, having a history of drug use or having an HIV-infected spouse who had never been exposed to antiretroviral treatment.
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Luxi 678400, China.
authors.forename: Song
authors.initials: S
authors.lastname: Duan
authors.forename: Yue-cheng
authors.initials: YC
authors.lastname: Yang
authors.forename: Li-fen
authors.initials: LF
authors.lastname: Xiang
authors.forename: Run-hua
authors.initials: RH
authors.lastname: Ye
authors.forename: Man-hong
authors.initials: MH
authors.lastname: Jia
authors.forename: Hong-bing
authors.initials: HB
authors.lastname: Luo
authors.forename: Yu-xian
authors.initials: YX
authors.lastname: Zhao
authors.forename: Da
authors.initials: D
authors.lastname: Ren
authors.forename: Yong-cheng
authors.initials: YC
authors.lastname: Pu
authors.forename: Wen-xiang
authors.initials: WX
authors.lastname: Han
authors.forename: Zhong-ju
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Wei-mei
authors.initials: WM
authors.lastname: Li
authors.forename: Ji-bao
authors.initials: JB
authors.lastname: Wang
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.forename: Zhuo-hua
authors.initials: ZH
authors.lastname: Fu
authors.forename: Na
authors.initials: N
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D018023:HIV Seronegativity; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012725:Sexual Behavior; D018454:Spouses; D055815:Young Adult