title: Alpha2B-adrenergic receptor insertion/deletion polymorphism in women with spontaneous recurrent abortions.
abstract: OBJECTIVE
  The aim of our study was to investigate the relationship between the alpha2B-adrenoreceptor insertion/deletion (I/D) polymorphism and recurrent spontaneous abortions (RSA).
  
  
  METHODS
  Genotyping was performed in 48 women with a history of at least three consecutive spontaneous abortions and 96 women with at least two live births and no history of pregnancy loss. Peripheral venous puncture, DNA extraction and PCR were used for the research of DD, ID and II genotype characters.
  
  
  RESULTS
  The distribution of DD, ID and II genotypes of the alpha2B-adrenoreceptor gene was 2 (4.2%), 19 (39.6%) and 27 (56.2%) in the study group and 6 (6.5%), 28 (30.4%) and 58 (63%) in the control group, respectively. There was no significant difference between the groups. The presence of the D allele was not associated with RSA (P = 0.78, odds ratio = 0.88, 95% CI = 0.47-1.65).
  
  
  CONCLUSIONS
  Our data fall short of showing any association between the presence of the alpha2B D allele and the occurrence of spontaneous abortions in the examined population.
authors.affiliation: Department of Obstetrics and Gynaecology, Democritus University of Thrace, Alexandroupolis, Thrace, Greece. ggalaz@med.duth.gr
authors.forename: Georgios
authors.initials: G
authors.lastname: Galazios
authors.forename: Demetrios
authors.initials: D
authors.lastname: Papazoglou
authors.forename: Christos
authors.initials: C
authors.lastname: Zografou
authors.forename: Efstratios
authors.initials: E
authors.lastname: Maltezos
authors.forename: Vasilios
authors.initials: V
authors.lastname: Liberis
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000595:Amino Acid Sequence; D005260:Female; D005838:Genotype; D006115:Greece; D006801:Humans; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic; D011247:Pregnancy; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D018341:Receptors, Adrenergic, alpha-2