title: Impact of polymorphisms of the genes encoding angiotensin II-forming enzymes on the progression of IgA nephropathy.
abstract: OBJECTIVE
  Angiotensin II has been shown to play an important role in various renal diseases. Genetic polymorphisms of the renin-angiotensin system have been reported to be related to the clinical outcomes in immunoglobulin A nephropathy (IgAN). We investigated the association of polymorphisms of the genes encoding major angiotensin II-forming enzymes with the development and progression of IgAN among Korean patients.
  
  
  METHODS
  A total of 261 IgAN patients and 300 healthy controls were studied. The polymorphisms of angiotensin-converting enzyme gene (I/D, A2350G) and chymase (CMA) gene (rs1800875, rs1800876) were determined.
  
  
  RESULTS
  No significant difference was observed in the genotype and allele frequencies of the polymorphisms between IgAN patients and controls. The frequency of AA/AG genotypes of CMA rs1800875 and CC/CT genotype of CMA rs1800876 were significantly higher in patients with progressive disease course than in those with stable course (53.2 vs. 38.6%, p = 0.029; 89.6 vs. 78.3%, p = 0.031, respectively). In the Cox regression model with adjustment for clinical risk factors, CMA rs1800875 AA/AG genotypes remained an independent risk factor (hazard ratio 2.351; p = 0.001).
  
  
  CONCLUSIONS
  Our results suggest that the CMA rs1800875 polymorphism is associated with the progression of IgAN in Korean patients.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Jung
authors.forename: Sun Moon
authors.initials: SM
authors.lastname: Kim
authors.forename: Ran-Hui
authors.initials: RH
authors.lastname: Cha
authors.forename: Yun Kyu
authors.initials: YK
authors.lastname: Oh
authors.forename: Yon Su
authors.initials: YS
authors.lastname: Kim
authors.forename: Suhnggwon
authors.initials: S
authors.lastname: Kim
authors.forename: Chun Soo
authors.initials: CS
authors.lastname: Lim
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D053818:Chymases / Q000235:genetics; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency / Q000502:physiology; D005922:Glomerulonephritis, IGA / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012083:Renin / Q000235:genetics*; D055815:Young Adult
chemical_list: D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D053818:Chymases; D012083:Renin