title: Angiosarcoma arising in an ovarian fibroma: a case report.
abstract: Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings.
authors.affiliation: Laboratório de Patologia, Hospital Conceição de Porto Alegre, Universidade Luterana do Brasil, B. Cristo Redentor, 91350-200 Porto Alegre, RS, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cambruzzi
authors.forename: Karla Lais
authors.initials: KL
authors.lastname: Pegas
authors.forename: Daniel Marini
authors.initials: DM
authors.lastname: Milani
authors.forename: Ricardo Pedrini
authors.initials: RP
authors.lastname: Cruz
authors.forename: Enilde Heloena
authors.initials: EH
authors.lastname: Guerra
authors.forename: Márcio Balbinotti
authors.initials: MB
authors.lastname: Ferrari