title: Silymarin-solid dispersions: characterization and influence of preparation methods on dissolution.
abstract: The influence of preparation methodology of silymarin solid dispersions using a hydrophilic polymer on the dissolution performance of silymarin was investigated. Silymarin solid dispersions were prepared using HPMC E 15LV by kneading, spray drying and co-precipitation methods and characterized by FTIR, DSC, XRPD and SEM. Dissolution profiles were compared by statistical and model independent methods. The FTIR and DSC studies revealed weak hydrogen bond formation between the drug and polymer, while XRPD and SEM confirmed the amorphous nature of the drug in co-precipitated solid dispersion. Enhanced dissolution compared to pure drug was found in the following order: co-precipitation > spray drying > kneading methodology (p < 0.05). All preparation methods enhanced silymarin dissolution from solid dispersions of different characteristics. The co-precipitation method proved to be best and provided a stable amorphous solid dispersion with 2.5 improved dissolution compared to the pure drug.
authors.affiliation: Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, Changa, India. sonali.dalwadi@yahoo.com
authors.forename: Dalwadi
authors.initials: D
authors.lastname: Sonali
authors.forename: Soni
authors.initials: S
authors.lastname: Tejal
authors.forename: Thakkar
authors.initials: T
authors.lastname: Vaishali
authors.forename: Gandhi
authors.initials: G
authors.lastname: Tejal
mesh_terms: D000284:Administration, Oral; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D001682:Biological Availability; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000378:metabolism; D011108:Polymers; D012838:Silymarin / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility
chemical_list: D000975:Antioxidants; D004304:Dosage Forms; D004337:Drug Carriers; D011108:Polymers; D012838:Silymarin; D065347:Hypromellose Derivatives; D008747:Methylcellulose