title: Effect of intranasal administration of anti-glutamate antibodies after stress exposure on the stress response.
abstract: We studied the dose-dependent effect of antibodies to glutamate on the stress response in C57Bl/6 mice. The antibodies were administered immediately after stress exposure. Intranasal administration of antibodies to glutamate in doses of 150 and 250 μg/kg immediately after stress exposure was shown to reduce the stress response under conditions of combined restraint stress. This effect was most pronounced after treatment with antibodies in a dose of 250 μg/kg: we revealed a decrease in the number and severity of erosive and ulcerative lesions in the gastric mucosa, i.e. anti-glutamate antibodies have a protective effect.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Evseev
authors.forename: L A
authors.initials: LA
authors.lastname: Vetrile
authors.forename: I A
authors.initials: IA
authors.lastname: Zaharova
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D001522:Behavior, Animal / Q000502:physiology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D018698:Glutamic Acid / Q000276:immunology*; D007101:Immersion; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology; D013312:Stress, Physiological / Q000276:immunology*
chemical_list: D000906:Antibodies; D018698:Glutamic Acid