title: Lubiprostone used with polyethylene glycol in diabetic patients enhances colonoscopy preparation quality.
abstract: OBJECTIVE
  To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte (PEG) for colonoscopy.
  
  
  METHODS
  This was an investigator-initiated, single-center, single-blinded prospective trial comparing the efficacy of L + PEG to PEG alone on colon preparation quality in diabetics undergoing screening colonoscopy. The study was approved by our institution's IRB. The PEG was given as a single-dose to address patient-compliance concerns voiced by our IRB with split-dosing. All patients received only clear liquids the day prior to colonoscopy. Experimental group (Grp L) received PEG + 1 dose L 2 h prior to and 2 h after PEG completion. Control group (Grp C) received only PEG the evening prior to the colonoscopy. Patients were randomly assigned to one of the 2 groups. The endoscopist was blinded to which colon prep was given and all colonoscopies were complete. Upon colonoscopy completion, the endoscopist rated the colon prep-quality by a validated 5-point Likert scale (1-excellent to 5-inadequate).
  
  
  RESULTS
  Sixty patients were enrolled in the study; 30 Grp L and 30 Grp C. Overall, patients were excluded due to study non-completion in 12 (41%) Grp L and 5 (17%) Grp C, P = 0.04. Average colon preparation score Grp L = 2.47 and Grp C = 3.00, P = 0.09. Although this was not statistically significant, there was a trend towards improved colon prep in Grp L. Statistical significance may have been achieved if completion rates had been similar between both study groups.
  
  
  CONCLUSIONS
  Use of 2-L capsules with PEG resulted in a trend towards improved colon prep over PEG alone in diabetic patients when given as a single-dose regimen.
authors.affiliation: Erika Grigg, Moonkyung C Schubert, Joshua Hall, Fadi Rahhal, Dimple Raina, Subbaramiah Sridhar, Sherman M Chamberlain, Section of Gastroenterology and Hepatology, Medical College of Georgia, Augusta, GA 30912, United States.
authors.forename: Erika
authors.initials: E
authors.lastname: Grigg
authors.forename: Moonkyung C
authors.initials: MC
authors.lastname: Schubert
authors.forename: Joshua
authors.initials: J
authors.lastname: Hall
authors.forename: Fadi
authors.initials: F
authors.lastname: Rahhal
authors.forename: Dimple
authors.initials: D
authors.lastname: Raina
authors.forename: Subbaramiah
authors.initials: S
authors.lastname: Sridhar
authors.forename: Sherman M
authors.initials: SM
authors.lastname: Chamberlain