title: Tinidazole vs metronidazole for the treatment of bacterial vaginosis.
abstract: OBJECTIVE
  The purpose of this study was to compare the efficacy of 2 different doses of tinidazole with metronidazole for the treatment of bacterial vaginosis and to compare the side effects of the drugs.
  
  
  METHODS
  Women were assigned randomly to receive metronidazole 500 mg twice daily, tinidazole 500 mg twice daily, or tinidazole 1 g twice, all for 7 days. Follow-up visits were conducted at days 14 and 28.
  
  
  RESULTS
  Five hundred ninety-three women were enrolled. There were no significant differences between the treatment arms. Overall cure rates were 76.8% at 14 days and 64.5% at 1 month. Women who admitted to engaging in sexual intercourse during the study were significantly more likely to have bacterial vaginosis at the follow-up visit. There were no significant differences in adverse events across treatment arms.
  
  
  CONCLUSIONS
  There were no differences in cure rates between metronidazole and either of the tinidazole dosing regimens that were studied. In addition, there were no important differences in the side-effect profiles of metronidazole and tinidazole.
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, 703 19th Street, Birmingham, AL 35294, USA. schwebke@uab.edu
authors.forename: Jane R
authors.initials: JR
authors.lastname: Schwebke
authors.forename: Renee A
authors.initials: RA
authors.lastname: Desmond
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D014011:Tinidazole / Q000008:administration & dosage*; D016585:Vaginosis, Bacterial / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D014011:Tinidazole; D008795:Metronidazole