title: Triclosan - an update.
abstract: The discovery in 1998 that triclosan has a site-specific action in the bacterial cell as an inhibitor of NADH- or NADPH-dependent enoyl-acyl carrier protein reductase led to a lively debate in the scientific press. The thesis of this debate was that such a mode of action may allow triclosan to induce resistance and cross-resistance in bacterial cells. The debate last saw review in 2004, and this paper aims at updating our knowledge in this area, given recent research on the topic.
authors.affiliation: School of Pharmacy, Applied Sciences University, Amman, Jordan.
authors.forename: S
authors.initials: S
authors.lastname: Saleh
authors.forename: R N S
authors.initials: RN
authors.lastname: Haddadin
authors.forename: S
authors.initials: S
authors.lastname: Baillie
authors.forename: P J
authors.initials: PJ
authors.lastname: Collier
mesh_terms: D004202:Disinfectants / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D054872:Fatty Acid Synthesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014260:Triclosan / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004202:Disinfectants; D004791:Enzyme Inhibitors; D054872:Fatty Acid Synthesis Inhibitors; D014260:Triclosan; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)