title: [Osteogenic and tracking study of bone marrow stromal stem cells in vivo].
abstract: OBJECTIVE
  To detect and track the presence of magnetically labeled bone marrow stromal cells (MSCs) in vivo with magnetic resonance imaging (MRI) after autologous transplantation.
  
  
  METHODS
  The cultured and SPIO-labeled MSCs were transplanted into dog femoral head. The dog received regular MRI re-examination at post-operation. Samples were harvested at different weeks for analysis.
  
  
  RESULTS
  The labeled cells showed an obviously low intensity of signal change in MRI. There were lots of labeled cells in the transplant area and more bone formation than the controls.
  
  
  CONCLUSIONS
  The labeled cells can be visualized in vivo by MRI examination after transplantation into femoral head. The transplanted MSCs survive in vivo and increase bone formation.
authors.affiliation: Department of Orthopedics, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Zi-rong
authors.initials: ZR
authors.lastname: Li
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Cheng
authors.forename: Wen
authors.initials: W
authors.lastname: Hong
authors.forename: Ran
authors.initials: R
authors.lastname: Yan
authors.forename: Lin
authors.initials: L
authors.lastname: Pan
authors.forename: Zhe
authors.initials: Z
authors.lastname: Cai
authors.forename: Jun
authors.initials: J
authors.lastname: Shu
mesh_terms: D000818:Animals; D015415:Biomarkers; D001854:Bone Marrow Cells / Q000166:cytology*; D016026:Bone Marrow Transplantation; D002478:Cells, Cultured; D004285:Dogs; D017886:Durapatite; D008279:Magnetic Resonance Imaging; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D014182:Transplantation, Autologous
chemical_list: D015415:Biomarkers; D017886:Durapatite