title: Efficiency of lyticase (bacterial enzyme) in experimental candidal vaginitis in mice.
abstract: Lyticase (a bacterial enzyme) was tested as a new antimycotic drug. Of all objects studied, Cellulomonas cellulans AC-870 strain proved to be most productive for this enzyme. A technology for lyticase isolation and purification was proposed. An experimental model of recurrent vaginal candidiasis was created. The model includes combined antibiotic and estradiol therapy. Antimycotic effect of lyticase on the model of recurrent vaginal candidiasis in mice was demonstrated.
authors.affiliation: Department of Microbiology, Russian University of Peoples' Friendship, Moscow, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Sachivkina
authors.forename: E G
authors.initials: EG
authors.lastname: Kravtsov
authors.forename: E A
authors.initials: EA
authors.lastname: Wasileva
authors.forename: I V
authors.initials: IV
authors.lastname: Anokchina
authors.forename: M V
authors.initials: MV
authors.lastname: Dalin
mesh_terms: D000818:Animals; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D005260:Female; D004693:Glucan Endo-1,3-beta-D-Glucosidase / Q000378:metabolism* / Q000627:therapeutic use; D051379:Mice; D009097:Multienzyme Complexes / Q000378:metabolism* / Q000627:therapeutic use; D010447:Peptide Hydrolases / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D009097:Multienzyme Complexes; C025310:lyticase; D004693:Glucan Endo-1,3-beta-D-Glucosidase; D010447:Peptide Hydrolases