title: Association between NFKB1 -94ins/delATTG promoter polymorphism and cancer risk: a meta-analysis.
abstract: The aim of our meta-analysis was to assess the association between NFKB1 -94ins/delATTG promoter polymorphism and cancer risk. Eleven studies that included data from 2,743 cases and 2,195 controls were identified. When all groups were pooled, we did not detect the association between NFKB1 -94ins/delATTG promoter polymorphism and cancer risk. In the subgroup analysis, we detected the association of NFKB1 -94ins/delATTG promoter polymorphism with cancer in Caucasian population. The association also was found in Asian population. This meta-analysis demonstrates the association of NFKB1 -94ins/delATTG promoter polymorphism with cancer in Caucasian and Asian populations, and this association is ethno-specific.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Zou
authors.forename: Feng-Lai
authors.initials: FL
authors.lastname: Yuan
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Feng
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Tao
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Pan
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human