title: Prevalence of human cytomegalovirus and Epstein-Barr virus in subgingival plaque at peri-implantitis, mucositis and healthy sites. A pilot study.
abstract: This study evaluated the prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites and the correlation between herpesvirus and clinical parameters. Fifty-six dental implants (mean time of loading, 4.27±1.6 years) were evaluated (20 peri-implantitis, 18 mucositis, 18 healthy peri-implant sites.) The clinical parameters assessed were: visible plaque index (PI), bleeding on probing (BOP), suppuration (SUP), probing depth (PD). A polymerase chain reaction assay identified HCMV and EBV in subgingival plaque samples. The percent of sites with plaque and BOP was significantly higher around mucositis and peri-implantitis compared with healthy implants (p<0.05). The mean PD around the implants was significantly higher in peri-implantitis, followed by mucositis and healthy implants (p<0.05). HCMV was detected in 13 (65%) and EBV in 9 (45%) of the 20 peri-implantitis sites. HCMV was found in 1 of the 18 (6%) healthy periodontal sites and EBV in 2 (11%). A statistically significant correlation was found between presence of HCMV and EBV subgingivally and clinical parameters of peri-implantitis and healthy sites. These results confirm the high prevalence of HCMV and EBV in subgingival plaque of peri-implantitis sites and suggest the viruses have a possible active pathogenic role in peri-implantitis.
authors.affiliation: University of Belgrade, School of Dentistry, Department of Periodontics, Belgrade, Serbia. drsashaj@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Jankovic
authors.forename: Z
authors.initials: Z
authors.lastname: Aleksic
authors.forename: B
authors.initials: B
authors.lastname: Dimitrijevic
authors.forename: V
authors.initials: V
authors.lastname: Lekovic
authors.forename: P
authors.initials: P
authors.lastname: Camargo
authors.forename: B
authors.initials: B
authors.lastname: Kenney
mesh_terms: D016301:Alveolar Bone Loss / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis; D015921:Dental Implants / Q000821:virology*; D003773:Dental Plaque / Q000821:virology*; D003774:Dental Plaque Index; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis; D005260:Female; D005884:Gingival Hemorrhage / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D057873:Peri-Implantitis / Q000821:virology*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000821:virology; D010519:Periodontium / Q000821:virology; D010865:Pilot Projects; D013280:Stomatitis / Q000821:virology*; D013492:Suppuration
chemical_list: D015921:Dental Implants