title: Dormant pulmonary vein conduction induced by adenosine in patients with atrial fibrillation who underwent catheter ablation.
abstract: BACKGROUND
  intravenous administration of adenosine triphosphate (ATP) is used to induce transient pulmonary vein (PV) reconduction (dormant PV conduction) following PV isolation. This study investigated the detailed characteristics of dormant PV conduction in patients with atrial fibrillation (AF) who underwent catheter ablation.
  
  
  METHODS
  two hundred sixty consecutive patients (235 men; mean age, 54 ± 10 years) who underwent catheter ablation of their AF were included in this study. ATP was injected following PV isolation to induce dormant PV conduction, which was then eliminated by radiofrequency application.
  
  
  RESULTS
  dormant PV conduction was induced by ATP in 60.4% (157/260) of the patients and in 25.3% (258/1,021) of the isolated PVs. This transient PV reconduction was more frequently observed in the left superior PV in comparison with other PVs (P < .0001). There was no significant difference in the prevalence of the dormant PV conduction among patients with paroxysmal AF, persistent AF, and long-lasting AF (62%, 66%, and 48%, respectively; P = .13). During the follow-up period, repeat AF ablation was performed in 70 patients with recurrent AF. The dormant PV conduction was less frequently induced in the repeat procedure than in the initial procedure (60.4% vs 31.4%, P < .0001).
  
  
  CONCLUSIONS
  dormant PV conduction was evenly induced among AF types. The repeat PV isolation led to the decrease in incidence of the ATP-induced acute transient pharmacological PV reconduction.
authors.affiliation: Department of Cardiology, Jikei University School of Medicine, Tokyo, Japan. mattsuu@tc4.so-net.ne.jp
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Matsuo
authors.forename: Teiichi
authors.initials: T
authors.lastname: Yamane
authors.forename: Taro
authors.initials: T
authors.lastname: Date
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lellouche
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Tokutake
authors.forename: Mika
authors.initials: M
authors.lastname: Hioki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ito
authors.forename: Ryohsuke
authors.initials: R
authors.lastname: Narui
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Tanigawa
authors.forename: Tokiko
authors.initials: T
authors.lastname: Nakane
authors.forename: Michifumi
authors.initials: M
authors.lastname: Tokuda
authors.forename: Seigo
authors.initials: S
authors.lastname: Yamashita
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aramaki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Inada
authors.forename: Kenri
authors.initials: K
authors.lastname: Shibayama
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyanaga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Abe
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Ikuo
authors.initials: I
authors.lastname: Taniguchi
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yoshimura
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000294:innervation* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D000241:Adenosine