title: [Effect of motilin receptor agonist-erythromycin on the glucose responsive neurons in hypothalamus of rats].
abstract: OBJECTIVE
  In order to explore the mechanism of central motilin-induced feeding behavior, the effects of erythromycin, a motilin receptor agonist, on glucose responsive neurons in hypothalamus were observed.
  
  
  METHODS
  Extracellular recordings were made from single neurons in region of lateral hypothalamic area (LHA) and ventromedial hypothalamic nucleus (VMH) in anesthetized rats. On the basis of their responsiveness to intracarotid injection of 0.58 mol/L glucose solution 0.2 ml, glucose-sensitive neurons (GSNs) in LHA and glucoreceptor neurons (GRNs) in VMH were recognized. Effects of intracerebroventricularly (i. c. v.) administration of 4 microg erythromycin on neural activities of glucose responsive neurons and non-glucose responsive neurons were examined. The mixture of EM and GM-109 1 microl were used to GSNs and GRNs which were sensitive to i. c. v. administration of EM.
  
  
  RESULTS
  In LHA, EM increased activity of GSNs significantly (P < 0.05 vs non-glucose-sensitive neurons group). Whereas in VMH, EM significantly decreased the activities of GRNs (P < 0.01 vs non-glucoreceptor neurons group). The mixture of EM and GM-109 had no effect on GSNs and GRNs.
  
  
  CONCLUSIONS
  EM, a motilin receptor agonist, can stimulate GSNs in LHA and suppress GRNs in VMH and this may contribute to central motilin's effect on feeding behavior.
authors.affiliation: Medical School of Qingdao University, Qingdao 266021, China.
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Sun
authors.forename: Ming
authors.initials: M
authors.lastname: Tang
authors.forename: Zheng-Yao
authors.initials: ZY
authors.lastname: Jiang
mesh_terms: D000818:Animals; D004917:Erythromycin / Q000494:pharmacology*; D007031:Hypothalamus / Q000166:cytology; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011964:Receptors, Gastrointestinal Hormone / Q000037:antagonists & inhibitors*; D018013:Receptors, Neuropeptide / Q000037:antagonists & inhibitors*
chemical_list: D011956:Receptors, Cell Surface; D011964:Receptors, Gastrointestinal Hormone; D018013:Receptors, Neuropeptide; C027786:glucose receptor; C050802:motilin receptor; D004917:Erythromycin