title: The effect of QMix, an experimental antibacterial root canal irrigant, on removal of canal wall smear layer and debris.
abstract: BACKGROUND
  This study examined the ability of two versions of QMix, an experimental antimicrobial irrigant, on removal of canal wall smear layers and debris using an open canal design.
  
  
  METHODS
  Cleaned and shaped single-rooted human root canals were irrigated with NaOCl as the initial irrigant and one of the following as the final irrigant: (1) QMix I (pH = 8), (2) QMix II (pH = 7.5), (3) distilled water, (4) 17% EDTA, and (5) BioPure MTAD (Dentsply Tulsa Dental Specialties, Tulsa, OK). Smear and debris scores were evaluated in the coronal, middle, and apical thirds of longitudinally fractured canal spaces using scanning electron microscopy and analyzed using Cochran-Mantel-Haenszel statistic.
  
  
  RESULTS
  Smear scores, when the overall canal was considered, differences were observed among groups except groups 1 versus 4 and groups 2 versus 4. After adjusting for canal levels, all groups differed significantly from each other (p < 0.005) with the exception of groups 2 versus 5. For the debris scores, no significant difference was observed among the treatment groups when the overall canal was considered and after adjusting for the effect of canal level.
  
  
  CONCLUSIONS
  Within the limitations of an open-canal design, the two experimental QMix versions are as effective as 17% EDTA in removing canal wall smear layers after the use of 5.25% NaOCl as the initial rinse.
authors.affiliation: Department of Stomatology, The First Hospital of Wuhan, Wuhan, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Dai
authors.forename: Khaled
authors.initials: K
authors.lastname: Khechen
authors.forename: Sara
authors.initials: S
authors.lastname: Khan
authors.forename: Brian
authors.initials: B
authors.lastname: Gillen
authors.forename: Bethany A
authors.initials: BA
authors.lastname: Loushine
authors.forename: Courtney E
authors.initials: CE
authors.lastname: Wimmer
authors.forename: James L
authors.initials: JL
authors.lastname: Gutmann
authors.forename: David
authors.initials: D
authors.lastname: Pashley
authors.forename: Franklin R
authors.initials: FR
authors.lastname: Tay
mesh_terms: D001645:Biguanides / Q000494:pharmacology*; D019343:Citric Acid / Q000494:pharmacology; D003786:Dental Pulp Cavity / Q000187:drug effects* / Q000648:ultrastructure; D004318:Doxycycline / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000379:methods; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011108:Polymers / Q000494:pharmacology*; D011136:Polysorbates / Q000494:pharmacology; D012388:Root Canal Irrigants / Q000737:chemistry / Q000494:pharmacology*; D018915:Root Canal Preparation / Q000379:methods*; D016369:Smear Layer; D012973:Sodium Hypochlorite / Q000494:pharmacology; D007507:Therapeutic Irrigation / Q000379:methods
chemical_list: D001645:Biguanides; C475043:MTAD (intracanal irrigant); D011108:Polymers; D011136:Polysorbates; C557698:QMix root canal irrigant; D012388:Root Canal Irrigants; D019343:Citric Acid; D004492:Edetic Acid; D012973:Sodium Hypochlorite; D004318:Doxycycline