title: CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population.
abstract: Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) A49G is a polymorphism that is extensively studied in various cancers. To investigate whether it is associated with the occurrence of glioma in Chinese patients, we performed a case-control research study with 670 patients and 680 controls. In this group, we found that the genotype at this locus is significantly associated with glioma risk (GG vs. AA: P = 0.045; GG + AG vs. AA: P = 0.013). In some subgroups, G allele carriers are significantly less represented. We also observed significant correlations between the polymorphism genotype and glioma risk in patients with WHO histologic stages. We conclude that CTLA4 A49G might be a potential clinical biomarker for distinguishing persons with a high risk for developing gliomas.
authors.affiliation: School of Life Science, East China Normal University, Shanghai, China.
authors.forename: Qihan
authors.initials: Q
authors.lastname: Wu
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhan
authors.forename: Tonghai
authors.initials: T
authors.lastname: Dou
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fan
authors.forename: Keke
authors.initials: K
authors.lastname: Zhou
authors.forename: Haishi
authors.initials: H
authors.lastname: Zhang
authors.forename: Hongxia
authors.initials: H
authors.lastname: Zheng
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Cai
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Fengping
authors.initials: F
authors.lastname: Huang
authors.forename: Liangfu
authors.initials: L
authors.lastname: Zhou
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D016543:Central Nervous System Neoplasms / Q000208:ethnology / Q000235:genetics*; D002648:Child; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human