title: [Rho GTPases as therapeutic targets in cancer and other human diseases].
abstract: Rho GTPases are a key protein family controlling the transduction of external signals to cytoplasmatic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases. The aim of this review is to describe the cellular functions regulated by these proteins with focus on the molecular mechanism involved. We also address the role of Rho GTPases in the development of different human diseases such as cancer. Finally, we describe different experimental therapeutic strategies with Rho GTPases as molecular targets.
authors.affiliation: Laboratorio de Oncología Molecular, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes.
authors.forename: Pablo
authors.initials: P
authors.lastname: Lorenzano Menna
authors.forename: Georgina A
authors.initials: GA
authors.lastname: Cardama
authors.forename: María J
authors.initials: MJ
authors.lastname: Comin
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Alonso
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Gómez
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D020741:rho GTP-Binding Proteins / Q000502:physiology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D020741:rho GTP-Binding Proteins