title: Synthesis of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, and evaluation of its proteasome inhibitory activities.
abstract: The total and semi syntheses of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, was accomplished. The proteasome inhibition and cytotoxic activities of the synthetic compound and its acetyl derivative were studied and compared with (2R, 3R)-epigallocatechin-3-gallate (EGCG), the active component from green tea.
authors.affiliation: Department of Applied Biology and Chemical Technology and the Open Laboratory for Chiral Technology, the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.
authors.forename: Kumi
authors.initials: K
authors.lastname: Osanai
authors.forename: Congde
authors.initials: C
authors.lastname: Huo
authors.forename: Kristin R
authors.initials: KR
authors.lastname: Landis-Piwowar
authors.forename: Q Ping
authors.initials: QP
authors.lastname: Dou
authors.forename: Tak Hang
authors.initials: TH
authors.lastname: Chan