title: Phytoconstituents from Vitex agnus-castus fruits.
abstract: A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.
authors.affiliation: UIC/NIH Center for Botanical Dietary Supplements Research, PCRPS, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Shao-Nong
authors.initials: SN
authors.lastname: Chen
authors.forename: J Brent
authors.initials: JB
authors.lastname: Friesen
authors.forename: Donna
authors.initials: D
authors.lastname: Webster
authors.forename: Dejan
authors.initials: D
authors.lastname: Nikolic
authors.forename: Richard B
authors.initials: RB
authors.lastname: van Breemen
authors.forename: Z Jim
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Harry H S
authors.initials: HH
authors.lastname: Fong
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Guido F
authors.initials: GF
authors.lastname: Pauli
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005419:Flavonoids / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry; D017705:Lignans / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification; D021241:Spectrometry, Mass, Electrospray Ionization; D013729:Terpenes / Q000302:isolation & purification; D020950:Vitex / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D017705:Lignans; D010636:Phenols; D013729:Terpenes; C553090:Vitex agnus castus extract; C560384:viteagnusin I