title: Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin.
abstract: Fibroblast growth factor 2 (FGF2) stimulates skin wound healing but does long-term delivery of FGF2 enhance skin regeneration compared to short-term delivery? Heparin-conjugated fibrin (HCF) was used as a vehicle for long-term delivery of FGF2. Fibrin, HCF, FGF2-loaded fibrin, and FGF2-loaded HCF were implanted into full-thickness skin defects of mice. The neoepidermis thickness was significantly larger in the FGF2-loaded HCF group than in the other groups, except for the FGF2-loaded fibrin group. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in the FGF2-loaded HCF group. The enhanced skin regeneration accompanying the long-term delivery of FGF2 could be mediated, at least partially, by enhanced neovascularization and cell proliferation in the neodermis.
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Suk Ho
authors.initials: SH
authors.lastname: Bhang
authors.forename: Ah-Young
authors.initials: AY
authors.lastname: Sun
authors.forename: Hee Seok
authors.initials: HS
authors.lastname: Yang
authors.forename: Taiyoun
authors.initials: T
authors.lastname: Rhim
authors.forename: Dong-Ik
authors.initials: DI
authors.lastname: Kim
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D005337:Fibrin / Q000737:chemistry / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism / Q000494:pharmacology; D006493:Heparin / Q000737:chemistry / Q000378:metabolism; D007150:Immunohistochemistry; D051379:Mice; D012038:Regeneration / Q000187:drug effects*; D012867:Skin / Q000187:drug effects*; D014945:Wound Healing
chemical_list: D016222:Fibroblast Growth Factor 2; D005337:Fibrin; D006493:Heparin