title: Regenerative medicine of the kidney.
abstract: End stage renal disease is a major health problem in this country and worldwide. Although dialysis and kidney transplantation are currently used to treat this condition, kidney regeneration resulting in complete healing would be a desirable alternative. In this review we focus our attention on current therapeutic approaches used clinically to delay the onset of kidney failure. In addition we describe novel approaches, like Tissue Engineering, Stem cell Applications, Gene Therapy, and Renal Replacement Therapy that may one day be possible alternative therapies for patients with the hope of delaying kidney failure or even stopping the progression of renal disease.
authors.affiliation: Division of Urology, Saban Research Institute, Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Blvd MS #35, Los Angeles, CA 90027, USA. lperin@chla.usc.edu
authors.forename: Laura
authors.initials: L
authors.lastname: Perin
authors.forename: Stefano
authors.initials: S
authors.lastname: Da Sacco
authors.forename: Roger E
authors.initials: RE
authors.lastname: De Filippo
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000503:physiopathology / Q000628:therapy*; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D017582:Renal Replacement Therapy / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods; D023822:Tissue Engineering / Q000379:methods