title: Distribution of normal nuchal translucency thickness: a multicenter study in Thailand.
abstract: OBJECTIVE
  To establish the normative data distribution of nuchal translucency (NT) thickness in Thai fetuses.
  
  
  METHODS
  A cross-sectional multicenter study was conducted among 6,455 women with singleton pregnancies and gestational age between 10 and 14 weeks. For each case, the fetal crown-rump length (CRL) and NT were measured by transabdominal ultrasound. Transvaginal ultrasounds were used in poorly visualized cases. The distribution values of the NT thicknesses and their corresponding 10-mm CRL intervals between 45 and 84 mm were examined to obtain the median and 95th percentiles. Quantile regression modeling across the CRLs was performed to obtain the reference values.
  
  
  RESULTS
  Transabdominal ultrasound measurements were successfully done on 6,347 fetuses with 39 cases by the transvaginal route. Fetuses with CRL between 45 and 84 mm and normal outcomes made up a total of 4,352 cases. The mean (SD) gestational age, CRL and NT thickness were 12.5 (0.7) weeks, 60.2 (9.7) mm, and 1.15 (0.38) mm, respectively. The mean normal NT increased linearly with CRL. The quantile regression equation to predict the 95th percentile of the NT thickness (mm) was 0.727 + [0.017 × CRL (mm)].
  
  
  CONCLUSIONS
  The NT thickness in normal Thai fetuses was found to be thinner than in both Caucasian and other Asian populations.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. ounjai.k@gmail.com
authors.forename: Ounjai
authors.initials: O
authors.lastname: Kor-Anantakul
authors.forename: Thitima
authors.initials: T
authors.lastname: Suntharasaj
authors.forename: Chitkasaem
authors.initials: C
authors.lastname: Suwanrath
authors.forename: Pharuhas
authors.initials: P
authors.lastname: Chanprapaph
authors.forename: Supatra
authors.initials: S
authors.lastname: Sirichotiyakul
authors.forename: Thawalwong
authors.initials: T
authors.lastname: Ratanasiri
authors.forename: Chutawadi
authors.initials: C
authors.lastname: Vuthiwong
authors.forename: Alan
authors.initials: A
authors.lastname: Geater
mesh_terms: D044466:Asian People; D003430:Cross-Sectional Studies; D005260:Female; D005333:Fetus / Q000033:anatomy & histology*; D006801:Humans; D048208:Nuchal Translucency Measurement / Q000706:statistics & numerical data*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012016:Reference Values; D013785:Thailand