title: [Mast cell and its relation to eosinophilic inflammation in CRSsNP].
abstract: OBJECTIVE
  To observe the pathologic characteristics, and investigate mast cell and its activation in chronic rhinosinusitis without nasal polyps (CRSsNP) and their relations with eosinophilic inflammation.
  
  
  METHODS
  HE stain was used to observe tissue features and count total inflammatory cells, mononuclear cells, plasma cells and eosinophilic in lamina propria of CRSsNP and inferior turbinate. Toluidine blue stain and immunohistochemical stain for tryptase were used to detect mast cell and its activation respectively in CRSsNP and control, and their corelations with tissue eosinophilia were analysed.
  
  
  RESULTS
  CRSsNP has increased total inflammatory cells, mononuclear cells and plasma cells but comparable eosinophilic and lamina propria glands compared with inferior turbinate. Mast cells corelated with activated mast cells, but there was no difference between CRSsNP and control for both of them and there were no corelation between mast cell and its activation with tissue eosinophilia.
  
  
  CONCLUSIONS
  CRSsNP has more serious inflammation but no more mast cell and its activation and eosinophil compared with inferior turbinate, and there were no corelations between mast cell and its activation with eosinophil count which suggests that mast cell and eosinophilic inflammation mediated by it may not play an important role in the pathogenesis of CRSsNP.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. caoping2009@hotmail.com
authors.forename: Pingping
authors.initials: P
authors.lastname: Cao
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Hua
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Hanqi
authors.initials: H
authors.lastname: Chu
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D004804:Eosinophils / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D008875:Middle Aged; D009298:Nasal Polyps / Q000473:pathology; D012852:Sinusitis / Q000473:pathology*; D013194:Staining and Labeling; D055815:Young Adult