title: Association between diabetic retinopathy and serum lipoproteins level.
abstract: BACKGROUND
  diabetic retinopathy is the leading cause of blindness of working-age patients in the urban areas.
  
  
  OBJECTIVE
  to find out the association between diabetic retinopathy and serum lipoproteins in patients with diabetes mellitus
  
  
  METHODS
  a community-based cross-sectional study involving 100 subjects with type II diabetes living in the cities of Kathmandu, Bhaktapur and Lalitpur of Nepal was carried out using a purposive sampling method. The retinopathy was classified according to the modified Airlie House classification of diabetic retinopathy. The patients with systolic hypertension were excluded. The blood sugar level was assessed by using glycosylated hemoglobin. The fasting serum lipoproteins were assessed by photometric enzymatic methods.
  
  
  METHODS
  the SPSS version 10.0 software was used. The p value of <0.05 was considered significant.
  
  
  RESULTS
  the majority (n=91) of the patients were in the age group 31-60 years with the mean of 48.2 +/- 9.5. The mean duration of diabetes mellitus in the patients with no-diabetic-retinopathy was 4 +/- 3.4 years and that in those with the retinopathy was 6.4 +/- 4years, (p =0.006). The mean glycosylated hemoglobin level for no-diabetic-retinopathy group was 6.9 1.1%, whereas for the diabetic retinopathy group, it was 7.7 +/- 1.5% (p = 0.004). The mean values of serum lipoproteins when taken together were slightly higher in the diabetic retinopathy group than in the group with no-diabetic-retinopathy. The serum triglyceride value was higher in the group with diabetic retinopathy than in the group with no retinopathy. Serum triglyceride had a low degree of positive correlation with HbA lc value.
  
  
  CONCLUSIONS
  there is no significant association between the serum lipoprotein levels and diabetic retinopathy in patients with type II diabetes mellitus. Serum triglyceride level has a low degree of positive correlation with HbA lc value.
authors.affiliation: Mechi Eye Care Center Birtamod, Jhapa Nepal. mecc@ntc.net.np
authors.forename: K
authors.initials: K
authors.lastname: Shakya
authors.forename: J K
authors.initials: JK
authors.lastname: Shrestha
authors.forename: S N
authors.initials: SN
authors.lastname: Joshi
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D011379:Prognosis; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008074:Lipoproteins