title: Liver transplantation using fatty livers: always feasible?
abstract: Steatotic liver grafts represent the most common type of "extended criteria" organs that have been introduced during the last two decades due to the disparity between liver transplant candidates and the number available organs. A precise definition and reliable and reproducible method for steatosis quantification is currently lacking and the potential influence of the chemical composition of hepatic lipids has not been addressed. In our view, these shortcomings appear to contribute significantly to the inconsistent results of studies reporting on graft steatosis and the outcome of liver transplantation. In this review, various definitions, prevalence and methods of quantification of liver steatosis will be covered. Ischemia/reperfusion injury of the steatotic liver and its consequences on post-transplant outcome will be discussed. Selection criteria for organ allocation and a number of emerging protective strategies are suggested.
authors.affiliation: Hepatobiliary Surgery and Liver Transplant Unit, Hospital Aleman of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Lucas
authors.initials: L
authors.lastname: McCormack
authors.forename: Philipp
authors.initials: P
authors.lastname: Dutkowski
authors.forename: Ashraf Mohammad
authors.initials: AM
authors.lastname: El-Badry
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Clavien
mesh_terms: D005234:Fatty Liver; D006801:Humans; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000639:trends*; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000639:trends*