title: [Cancer stem cells in solid tumors].
abstract: In this review, we discuss recent issues about cancer stem cells, especially in solid tumors. Cancer stem cells show the ability to self-renew; and they possess multi-potential differentiation and tumorigenic potential. Cancer stem cells are reported to show resistance to anticancer drugs and radiotherapy, and therefore, they are involved in progression, recurrence, and metastasis in cancer. The existence of cancer stem cells in leukemia has long been known, since early times. In recent years cancer stem cells have been identified in solid tumors of breast, prostate, lung, brain, colon, and pancreas, owing to the development of identification techniques using cell surface markers. Although many features remain to be addressed, it is expected that cancer stem cells could be a main target for cancer therapy in the near future.
authors.affiliation: Dept. of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University.
authors.forename: Hajime
authors.initials: H
authors.lastname: Hirose
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Norikatsu
authors.initials: N
authors.lastname: Miyoshi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Uemura
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takemasa
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Mizushima
authors.forename: Masataka
authors.initials: M
authors.lastname: Ikeda
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Sekimoto
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000473:pathology