title: Behavioral drug and HIV risk reduction counseling (BDRC) in MMT programs in Wuhan, China: a pilot randomized clinical trial.
abstract: This pilot clinical trial evaluated whether the efficacy of methadone maintenance treatment (MMT) provided with limited psychosocial services is improved by the addition of manual-guided behavioral drug and HIV risk reduction counseling (BDRC). Heroin dependent individuals (n=37) enrolling in two MMT clinics in Wuhan, China, received standard MMT services, consisting of daily medication at the clinics and infrequent additional services on demand, and were randomly assigned to MMT only (n=17) or MMT with weekly individual BDRC (n=20) for 3 months. Participants were followed for six months from the time of enrollment (3 months active counseling phase and 3 months follow-up while treated with standard MMT). Primary outcome measures included reductions of HIV risk behaviors and illicit opiate use and treatment retention. Participants were 81% male; mean (SD) age 36.7 (7.2) years; there were no significant baseline differences between the two groups. Participants in MMT+BDRC achieved both greater reductions of HIV risk behaviors (p<0.01), as indicated by the scores on a short version of the AIDS Risk Inventory, and of illicit opiate use, as indicated by the proportions of opiate negative test results during the active phase of the study and the follow-up (p<0.001). 83.3% in the MMT+BDRC group and 76.2% in the standard MMT group were still actively participating in MMT at 6 months. Manual-guided behavioral drug and HIV risk reduction counseling is feasible to deliver by the trained MMT nursing personnel and appears to be a promising approach for improving the efficacy of standard MMT services in China.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, 34 Park St., New Haven, CT 06519, USA. marek.chawarski@yale.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Chawarski
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: R S
authors.initials: RS
authors.lastname: Schottenfeld
mesh_terms: D000328:Adult; D002681:China; D003376:Counseling / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D006679:HIV Seropositivity / Q000378:metabolism; D006556:Heroin Dependence / Q000188:drug therapy / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000627:therapeutic use*; D009294:Narcotics / Q000008:administration & dosage / Q000627:therapeutic use*; D058850:Opiate Substitution Treatment / Q000379:methods*; D009293:Opioid-Related Disorders / Q000188:drug therapy / Q000534:rehabilitation; D010865:Pilot Projects; D040242:Risk Reduction Behavior; D012309:Risk-Taking; D019966:Substance-Related Disorders / Q000517:prevention & control* / Q000523:psychology; D013695:Temperance / Q000523:psychology
chemical_list: D009294:Narcotics; D008691:Methadone