title: [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices].
abstract: OBJECTIVE
  To explore the effect of platelet-activating factor on long-term potentiation in the CA1 region of rat hippocampal slices.
  
  
  METHODS
  We recorded the excitatory postsynaptic potentials (EPSPs) and investigated effect of long-term potentiation by PAF in rat hippocampus in vitro.
  
  
  RESULTS
  Low doses (1 micromol/L ) of PAF could induce LTP, while higher doses (10-50 micromol/L) of PAF could inhibit induction of LTP. But it couldn't inhibit the LTP induced by subsequent high frequency stimulation and the EPSP of basal. GB of PAF receptor antagonists could prevent the LTP induced by low doses of PAF, and could't inhibit the LTP induced by HFS.
  
  
  CONCLUSIONS
  Higher doses of PAF is an HIV-1-induced neurotoxin, it may contribute to the HAD pathogenesis by inhibition of LTP.
authors.affiliation: Department of Pathophysiology, Medical College of Jinan University, Guangzhou 510632, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.forename: Da-xiang
authors.initials: DX
authors.lastname: Lu
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.forename: Sui-mei
authors.initials: SM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology*; D017774:Long-Term Potentiation; D008297:Male; D009924:Organ Culture Techniques; D010972:Platelet Activating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010972:Platelet Activating Factor