title: Vitamin D receptor polymorphisms in liver transplant recipients.
abstract: OBJECTIVE
  Liver transplant is an established treatment for end-stage liver failure. Vitamin D has been shown to exert multiple immunomodulatory effects, which act through its own receptor (vitamin D receptor). In the present study, the association between Iranian patients with liver transplant and the polymorphism of vitamin D receptor FokI T>C (rs10735810) was investigated.
  
  
  METHODS
  The candidate gene locus was genotyped in 51 liver transplant recipients, and the association of each genotype with allograft acute rejection was evaluated.
  
  
  RESULTS
  In this study, we found no evidence to suggest that vitamin D receptor FokI polymorphism determines the incidence of acute rejection after liver transplant. The distribution of alleles was not different according to the underlying liver disease.
  
  
  CONCLUSIONS
  Larger epidemiologic studies are needed to elucidate the importance of vitamin D receptor gene polymorphism in transplant recipients.
authors.affiliation: Organ Transplant Research CenterPathology Department, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. negarazarpira@yahoo.com
authors.forename: Negar
authors.initials: N
authors.lastname: Azarpira
authors.forename: Heshmatolah
authors.initials: H
authors.lastname: Salahi
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.forename: Masumeh
authors.initials: M
authors.lastname: Daraie
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D018912:Arabs / Q000235:genetics; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007492:Iran; D016031:Liver Transplantation / Q000009:adverse effects / Q000208:ethnology; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol