title: [Vinculin and the androgen receptor in prostate cancer: expressions and correlations].
abstract: OBJECTIVE
  To investigate the expressions of vinculin (VCL) and the androgen receptor (AR) in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) and analyze their relationship with the clinical stage and pathological grade of PCa and the level of PSA.
  
  
  METHODS
  We detected the expressions of VCL and AR in 18 cases of BPH and 38 cases of PCa by immunohistochemistry, analyzed the differences of VCL and AR expressions in BPH and PCa in different clinical stages and pathological grades of PCa, compared the primary levels of PSA, and studied their correlations.
  
  
  RESULTS
  The positive rate of VCL was significantly higher in PCa than in BPH tissues (P < 0.05), while that of AR showed no significant differences between the two groups (P > 0.05). Both the expressions of VCL and AR were closely related with the clinical stage and pathological grade of PCa (P < 0.05), but not with the PSA level (P > 0.05). There was a positive correlation between the expressions of VCL and AR in PCa tissues (r = 0.489, P < 0.05).
  
  
  CONCLUSIONS
  VCL is expressed differently in BPH and PCa, which may serve as an indicator for the differential diagnosis of benign and malignant prostate diseases. The expressions of AR and VCL are gradually reduced with the progression of PCa, with a positive correlation between them, and could be used jointly to evaluate the progression and prognosis of PCa.
authors.affiliation: Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China. 3591726@qq.com
authors.forename: Li-yong
authors.initials: LY
authors.lastname: Zhu
authors.forename: Kuang-biao
authors.initials: KB
authors.lastname: Zhong
authors.forename: Shen-xiu
authors.initials: SX
authors.lastname: Lu
authors.forename: Le-ye
authors.initials: LY
authors.lastname: He
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism*; D016596:Vinculin / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen; D016596:Vinculin