title: [Effect of asymmetry elastic on the maturation of bone collagen and mineralization in condyle of adult SD rat].
abstract: OBJECTIVE
  The aim of this investigation was to study the osteogenesis activation following asymmetric inter-maxillary elastic on the subchondral bone of adult SD rats.
  
  
  METHODS
  Twenty SD ten-week old rats were used in this study (eight rats loading 0.39 N elastic force, another eight rats loading 1.18 N elastic force, the other four rats without loading as control group). The extra-joint device was fixed on the right side by surgery. Tetracycline, calcein and xylenol orange were intraperitoneally injected on one day before surgery, one day before device removal and one day before sacrifice. Masson trichrome staining and in vivo fluorescence technique were used to detect the osteogenesis.
  
  
  RESULTS
  The results of bone collagen maturation and velocity of osteogenesis were different from the control group after force loading. Bone collagen showed better maturity in force-loading side and light force induced more active osteogenesis.
  
  
  CONCLUSIONS
  The results suggest that even in the adult SD individuals, the subchondral bone still shows remodeling ability to adapt the various mechanical environments. Stress increases the maturity of bone collagen while rotation inhibits maturity. Mechanic force promotes the osteogenesis, especially the light force.
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. wutuojiang@163.com
authors.forename: Tuo-jiang
authors.initials: TJ
authors.lastname: Wu
authors.forename: Yue
authors.initials: Y
authors.lastname: Xu
authors.forename: Huang
authors.initials: H
authors.lastname: Li
authors.forename: Ling-li
authors.initials: LL
authors.lastname: Qu
authors.forename: Yang-xi
authors.initials: YX
authors.lastname: Chen
mesh_terms: D000818:Animals; D003094:Collagen; D008335:Mandibular Condyle; D010012:Osteogenesis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003094:Collagen