title: Alzheimer's Disease Drug Discovery--11th International Conference--Targeting Pathological Tau. 27-28 September 2010, Jersey City, NJ, USA.
abstract: The 11th Alzheimer's Disease Drug Discovery International Conference, held in Jersey City, NJ, USA, included topics covering new therapeutic developments in the field of Alzheimer's disease. This conference report highlights selected presentations on targeting pathological tau for the prevention or treatment of Alzheimer's disease. Investigational approaches discussed include aminothienopyridazine inhibitors of tau aggregation, the alternative splicing of tau pre-mRNA, protein phosphatase 2A as a potential therapeutic target, and immunotherapy and macroautophagy approaches for clearing aberrant tau protein from the brain.
authors.affiliation: Brigham & Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. mwolfe@rics.bwh.harvard.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolfe
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D001343:Autophagy / Q000187:drug effects; D055808:Drug Discovery; D057180:Frontotemporal Dementia / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D054648:Protein Phosphatase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D024801:Tauopathies / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D016875:tau Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D016875:tau Proteins; D054648:Protein Phosphatase 2