title: Effect of glyprolines PGP, GP, and PG on homeostasis of gastric mucosa in rats with experimental ethanol-induced gastric ulcers.
abstract: The decrease in the severity of erosions and ulcer lesions after preventive treatment with PGP or PG correlated with a decrease in the content of lipid peroxidation products to a control level. Activities of SOD and catalase also returned to control values. GP produced the weakest effect on pro- and antioxidant state of the gastric mucosa. We concluded that the pronounced preventive effect of PGP and PG on the development of ethanol-induced erosions and ulcer lesions is largely determined by their antioxidant properties. Glyprolines can be considered as a promising means for prevention and treatment of stomach and duodenal ulcers.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University, Russia.
authors.forename: T M
authors.initials: TM
authors.lastname: Falalyeyeva
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: T V
authors.initials: TV
authors.lastname: Beregovaya
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: E A
authors.initials: EA
authors.lastname: Dvorshchenko
mesh_terms: D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D015227:Lipid Peroxidation; D008297:Male; D011392:Proline / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000378:metabolism
chemical_list: D000431:Ethanol; D011392:Proline