title: [TTF-1 (8G7G3/1) positive colon adenocarcinoma: diagnostic implications].
abstract: Immunohistochemical evaluation of primary and secondary (adeno-) carcinomas of the lung often includes utilisation of two different clones (8G7G3/1 or SPT24) of TTF-1 (thyroid transcription factor 1) antibodies. In a subgroup of adenocarcinomas with a primary site other than the lung a positive reaction of clone SPT24 and also of clone 8G7G3/1 is described. We report on a patient with TTF-1 (clone 8G7G3/1) positive adenocarcinoma of the colon with metastases to the eye and lung and discuss TTF-1 based diagnostic considerations.
authors.affiliation: Institut für Pathologie und Neuropathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Deutschland. Henning.Reis@uk-essen.de
authors.forename: H G
authors.initials: HG
authors.lastname: Reis
authors.forename: C H D
authors.initials: CH
authors.lastname: Metz
authors.forename: H A
authors.initials: HA
authors.lastname: Baba
authors.forename: N
authors.initials: N
authors.lastname: Bornfeld
authors.forename: K W
authors.initials: KW
authors.lastname: Schmid
authors.forename: K A
authors.initials: KA
authors.lastname: Metz
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary*; D000368:Aged; D059186:Chemoradiotherapy, Adjuvant; D002829:Choroid / Q000473:pathology; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D004268:DNA-Binding Proteins / Q000032:analysis*; D018450:Disease Progression; D015353:Eye Enucleation; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D009367:Neoplasm Staging; D019721:Ophthalmoscopes; D012811:Sigmoid Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; C504003:TTF1 protein, human; D014157:Transcription Factors