title: Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October-November 2010.
abstract: An outbreak of flaccid paralysis syndrome in adults is ongoing in Congo. Molecular analysis of faecal, throat and cerebrospinal samples identified wildtype 1 poliovirus and an additional enterovirus C strain related to enterovirus 109 as the cause. As of 22 November, the cumulative number of cases was 409, of which 169 (41.3%) were fatal. This is one of the largest wild type 1 poliovirus outbreaks ever described associated with an unusually high case fatality rate.
authors.affiliation: Centre International de Recherches Medicales de Franceville (CIRMF, International Centre of Medical Research of Francville), Franceville, Gabon.
authors.forename: G
authors.initials: G
authors.lastname: Grard
authors.forename: J F
authors.initials: JF
authors.lastname: Drexler
authors.forename: S
authors.initials: S
authors.lastname: Lekana-Douki
authors.forename: M
authors.initials: M
authors.lastname: Caron
authors.forename: A
authors.initials: A
authors.lastname: Lukashev
authors.forename: D
authors.initials: D
authors.lastname: Nkoghe
authors.forename: J P
authors.initials: JP
authors.lastname: Gonzalez
authors.forename: C
authors.initials: C
authors.lastname: Drosten
authors.forename: E
authors.initials: E
authors.lastname: Leroy
mesh_terms: D000328:Adult; D003223:Congo / Q000453:epidemiology; D004196:Disease Outbreaks; D030015:Enterovirus C, Human / Q000235:genetics / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000821:virology; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010243:Paralysis / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D011051:Poliomyelitis / Q000453:epidemiology* / Q000209:etiology / Q000821:virology; D017955:Poliovirus / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D017422:Sequence Analysis, DNA