title: An Indian perspective on primary angle closure and glaucoma.
abstract: OBJECTIVE
  To provide a synopsis of primary angle closure disease in India, and Indian studies on the same.
  
  
  RESULTS
  Primary angle closure glaucoma forms almost half of all adult primary glaucomas seen in a hospital setting in India. Anatomically, corneal diameters and anterior chamber depths were least in acute and chronic PACG eyes as compared to subacute eyes and controls. Besides relative pupillary block, a Valsalva maneuver during activities of daily living may be responsible for intermittent angle closure and raised IOP in predisposed eyes. Iridotomy alone, controlled the intraocular pressure in 66.7% of subacute eyes and 12.9% of the acute. Medical therapy was additionally required for 35.5% of the acute eyes, 12.1% of the subacute and 30.0% of the chronic cases. There was a greater mean and peak IOP reduction, achieved with 0.005% latanoprost once daily, 8.2 ± 2.0 mm Hg, compared with 0.5% timolol twice daily, 6.1 ± 1.7 mm Hg2. A progression of PACS to PAC was seen in 22%, PAC to PAC OHT in 38.7% and PAC OHT to PACG in 30.7% over 5 years.
  
  
  CONCLUSIONS
  Primary angle closure disease is common in India, and can be managed well with iridotomy, followed by an appropriate control of IOP.
authors.affiliation: Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India. rjsihota@hotmail.com
authors.forename: Ramanjit
authors.initials: R
authors.lastname: Sihota
mesh_terms: D000208:Acute Disease; D000867:Anterior Chamber / Q000473:pathology; D000959:Antihypertensive Agents / Q000008:administration & dosage; D002908:Chronic Disease; D003315:Cornea / Q000473:pathology; D018450:Disease Progression; D004334:Drug Administration Schedule; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007498:Iris / Q000601:surgery; D000077338:Latanoprost; D009798:Ocular Hypertension / Q000150:complications; D013508:Ophthalmologic Surgical Procedures; D015995:Prevalence; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage; D013999:Timolol / Q000008:administration & dosage
chemical_list: D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D013999:Timolol