title: Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems.
abstract: 3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (2) was used as the key molecule for preparation of various furopyrimidines 3-9 and formation of spiro-cycloalkane furopyrimidines 10, 11. Also, poly fused heterocyclic compounds 13-17 were prepared from compound 2. The synthesized compounds were screened for their antimicrobial activity.
authors.affiliation: Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: Hayam H
authors.initials: HH
authors.lastname: Sayed
authors.forename: Hebat-Allah S
authors.initials: HA
authors.lastname: Abbas
authors.forename: Eman M H
authors.initials: EM
authors.lastname: Morsi
authors.forename: Abd El-Galil E
authors.initials: Ael-G
authors.lastname: Amr
authors.forename: Nayera A M
authors.initials: NA
authors.lastname: Abdelwahad
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D044366:Transition Temperature
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011743:Pyrimidines