title: Marine bacterial sialyltransferases.
abstract: Sialyltransferases transfer N-acetylneuraminic acid (Neu5Ac) from the common donor substrate of these enzymes, cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac), to acceptor substrates. The enzymatic reaction products including sialyl-glycoproteins, sialyl-glycolipids and sialyl-oligosaccharides are important molecules in various biological and physiological processes, such as cell-cell recognition, cancer metastasis, and virus infection. Thus, sialyltransferases are thought to be important enzymes in the field of glycobiology. To date, many sialyltransferases and the genes encoding them have been obtained from various sources including mammalian, bacterial and viral sources. During the course of our research, we have detected over 20 bacteria that produce sialyltransferases. Many of the bacteria we isolated from marine environments are classified in the genus Photobacterium or the closely related genus Vibrio. The paper reviews the sialyltransferases obtained mainly from marine bacteria.
authors.affiliation: Glycotechnology Business Unit, Japan Tobacco Inc., 700 Higashibara, Iwata, Shizuoka 438-0802, Japan. takeshi.yamamoto@jt.com
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology*; D003569:Cytidine Monophosphate N-Acetylneuraminic Acid / Q000378:metabolism; D006801:Humans; D008386:Marine Biology; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D010776:Photobacterium / Q000201:enzymology; D012799:Sialyltransferases / Q000378:metabolism*; D014733:Vibrio / Q000201:enzymology
chemical_list: D003569:Cytidine Monophosphate N-Acetylneuraminic Acid; D012799:Sialyltransferases; D019158:N-Acetylneuraminic Acid