title: [The role of depression in cognitive impairment in patients with chronic fatigue syndrome].
abstract: OBJECTIVE
  To analyze the role of depression in cognitive deficits of patients with chronic fatigue syndrome (CFS).
  
  
  METHODS
  57 women with CFS were assessed by neuropsychological tests that included measures of attention: CalCap, Mental control of the WMS-III, PASAT, forward and backward digits (WAIS-III), symbol digit modalities test (SDMT); executive functions: Stroop Test, Trail Making Test (TMT A y B), FAS, Tower of London; memory: Auditory-Verbal Learning Test (AVL), Rey Complex Figure (RCF), and psychomotor skills: Grooved Pegboard. The raw scores on the tests were adjusted according to normative data and transformed to T scores. The sample was divided into two groups based on the presence or absence of depression, assessed by clinical interview and administration of the Hospital Anxiety and Depression Scale (HADS). This study compared neuropsychological test scores between the two groups.
  
  
  RESULTS
  CFS patients showed cognitive deficit in attention and executive functions, regardless of the presence of depression. There were no significant differences between the two CFS groups.
  
  
  CONCLUSIONS
  The cognitive impairments in patients with CFS are not secondary to the presence of depression. These results should be taken into account in the implementation of therapeutic programs in these patients.
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario Vall d'Hebron, Universitat Autònoma de Barcelona, España. psantamarina@vhebron.net
authors.forename: Pilar
authors.initials: P
authors.lastname: Santamarina-Pérez
authors.forename: Verónica
authors.initials: V
authors.lastname: Freniche
authors.forename: Francisco Jose
authors.initials: FJ
authors.lastname: Eiroa-Orosa
authors.forename: Guillem
authors.initials: G
authors.lastname: Llobet
authors.forename: Naia
authors.initials: N
authors.lastname: Sáez
authors.forename: José
authors.initials: J
authors.lastname: Alegre
authors.forename: Carlos
authors.initials: C
authors.lastname: Jacas
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology*; D003863:Depression / Q000150:complications*; D015673:Fatigue Syndrome, Chronic / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged