title: Lipoblast-like signet-ring cells in neurofibroma: a potential diagnostic pitfall of malignancy.
abstract: Benign peripheral nerve sheath tumours, including neurofibroma, may occasionally contain a heterologous mature fatty component. Additional lipoblast-like cells can be occasionally identified among mature adipocytes. We report the first case of a plexiform neurofibroma from a NF1 patient containing exclusively lipoblast-like cells exhibiting morphological and immunohistochemical features identical to univaculoted lipoblasts typically seen in myxoid liposarcoma. Awareness of the possibility that an otherwise typical neurofibroma may contain lipoblast-like cells is crucial for the pathologist to avoid a misdiagnosis of malignancy. Differential diagnostic problems and histogenetic considerations are provided.
authors.affiliation: Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Italy.
authors.forename: G M
authors.initials: GM
authors.lastname: Vecchio
authors.forename: P
authors.initials: P
authors.lastname: Amico
authors.forename: G
authors.initials: G
authors.lastname: Leone
authors.forename: L
authors.initials: L
authors.lastname: Salvatorelli
authors.forename: G
authors.initials: G
authors.lastname: Magro
mesh_terms: D017667:Adipocytes / Q000473:pathology*; D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D018208:Liposarcoma, Myxoid; D008297:Male; D009456:Neurofibromatosis 1 / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000473:pathology*