title: Association of ADAM33 gene with susceptibility to COPD in Tibetan population of China.
abstract: Chronic obstructive pulmonary disease (COPD) is a common, complex disorder associated with substantial morbidity and mortality, influenced by both environmental factor and genetic factor. ADAM33 gene was found to be associated with asthma, declined lung function and COPD. The purpose of the study was to test whether SNPs in ADAM33 were associated with COPD in Tibetan population of China. Polymerase chain reaction-restriction fragment length polymorphism was carried out to genotype the eight SNPs (V4, T2, T1, S2, S1, Q-1 and F + 1) of ADAM33 on 240 COPD patients and 221 healthy individuals. Four SNPs (V4, T2, T1 and S1) and four haplotypes (H2 CGAAGAGC, H5 GAGAGAGC, H9 GAAAGAGC and H6 CGGGGAGC of ADAM33 gene were associated with COPD significantly (defined as P < 0.05). The results indicate that there is an association between ADAM33 polymorphisms and COPD in Tibetan population of China.
authors.affiliation: Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China. xiaojinlingxiao@yahoo.com.cn
authors.forename: Jinling
authors.initials: J
authors.lastname: Xiao
authors.forename: Jianyu
authors.initials: J
authors.lastname: Han
authors.forename: Xinyan
authors.initials: X
authors.lastname: Wang
authors.forename: Demi
authors.initials: D
authors.lastname: Hua
authors.forename: Dongju
authors.initials: D
authors.lastname: Su
authors.forename: Yongxia
authors.initials: Y
authors.lastname: Bao
authors.forename: Fuzhen
authors.initials: F
authors.lastname: Lv
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000483:Alleles; D001483:Base Sequence; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology* / Q000235:genetics*; D018609:Tibet
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human