title: [Using two-stage case-control designs to study the genome-wide association].
abstract: Genome-wide association study is an important approach to identify common genetic variants that predispose to human disease. Because of the high cost of genotyping on hundreds of thousands of markers on thousands of subjects, a more cost-effective two-stage case-control design is applied by most genome-wide association studies. To describe the design and statistical methods of the two-stage case-control study, this paper introduces the principles of two-stage case-control design, its implementing steps in genome-wide association study and the features of its application. The method is illustrated with an example.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Zhao-jun
authors.initials: ZJ
authors.lastname: Ma
authors.forename: Hong-gang
authors.initials: HG
authors.lastname: Yi
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D016022:Case-Control Studies; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D012107:Research Design