title: Hemoptysis under diclofenac and antiplatelet doses of aspirin.
abstract: A previously healthy 60-year-old man receiving aspirin for primary prevention of cardiovascular disease presented with hemoptysis after 1 week of treatment for his back pain with diclofenac. He had not suffered from any bleeding episode in the past and his family history was negative for hemorrhagic disorders. He had been a heavy smoker until his thirties, but had stopped smoking since then. After extensive workup, other pulmonary and nonpulmonary causes of hemoptysis were ruled out. Thus, in this case, because of the temporal relationship between exposure to the drug and the onset of symptoms, diclofenac was considered as the most probable cause of hemoptysis either alone or as a result of its pharmacodynamic interaction with aspirin. The adverse reaction was considered probable according to the Naranjo scale. Diclofenac treatment was discontinued and occasional use of acetaminophen for the back pain was recommended. Regular use of antiplatelet doses of aspirin was also discontinued.
authors.affiliation: Department of Basic Medical Lessons, Faculty of Health and Caring Professions, Technological Educational Institute of Athens, Athens, Greece. nyiannak@teiath.gr
authors.forename: Eugenia C
authors.initials: EC
authors.lastname: Yiannakopoulou
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001416:Back Pain / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000517:prevention & control; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D006469:Hemoptysis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004366:Nonprescription Drugs; D010975:Platelet Aggregation Inhibitors; D004008:Diclofenac; D001241:Aspirin