title: Valproate decreases frequency facilitation at mossy fiber--CA3 synapses after status epilepticus.
abstract: Mossy fiber to CA3 synapses exhibit metaplasticity during the development of epilepsy, and valproate in control animals can modulate long-term plasticity at this synapse. Here we show that valproate alters frequency facilitation (short-term plasticity) at this synapse in hippocampal slices from post-status epilepticus but not control animals. This indicates that valproate can have specific actions in the "epileptic" brain.
authors.affiliation: UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: Pishan
authors.initials: P
authors.lastname: Chang
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Walker
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D056654:CA3 Region, Hippocampal / Q000503:physiopathology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D055724:Electrophysiological Phenomena; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D008297:Male; D008839:Microelectrodes; D019599:Mossy Fibers, Hippocampal / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology*; D013569:Synapses / Q000502:physiology; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid