title: GermOnline 4.0 is a genomics gateway for germline development, meiosis and the mitotic cell cycle.
abstract: GermOnline 4.0 is a cross-species database portal focusing on high-throughput expression data relevant for germline development, the meiotic cell cycle and mitosis in healthy versus malignant cells. It is thus a source of information for life scientists as well as clinicians who are interested in gene expression and regulatory networks. The GermOnline gateway provides unlimited access to information produced with high-density oligonucleotide microarrays (3'-UTR GeneChips), genome-wide protein-DNA binding assays and protein-protein interaction studies in the context of Ensembl genome annotation. Samples used to produce high-throughput expression data and to carry out genome-wide in vivo DNA binding assays are annotated via the MIAME-compliant Multiomics Information Management and Annotation System (MIMAS 3.0). Furthermore, the Saccharomyces Genomics Viewer (SGV) was developed and integrated into the gateway. SGV is a visualization tool that outputs genome annotation and DNA-strand specific expression data produced with high-density oligonucleotide tiling microarrays (Sc_tlg GeneChips) which cover the complete budding yeast genome on both DNA strands. It facilitates the interpretation of expression levels and transcript structures determined for various cell types cultured under different growth and differentiation conditions. Database URL: www.germonline.org/
authors.affiliation: Inserm, U625, GERHM, IFR-140, Université de Rennes 1, F-35042 Rennes, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Lardenois
authors.forename: Alexandre
authors.initials: A
authors.lastname: Gattiker
authors.forename: Olivier
authors.initials: O
authors.lastname: Collin
authors.forename: Frédéric
authors.initials: F
authors.lastname: Chalmel
authors.forename: Michael
authors.initials: M
authors.lastname: Primig
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D022126:Access to Information; D000818:Animals; D047369:Chromatin Immunoprecipitation; D030541:Databases, Genetic; D030562:Databases, Protein; D016678:Genome / Q000235:genetics; D023281:Genomics / Q000379:methods*; D005854:Germ Cells / Q000166:cytology* / Q000254:growth & development*; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D008938:Mitosis / Q000235:genetics*; D058977:Molecular Sequence Annotation; D020411:Oligonucleotide Array Sequence Analysis; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D020413:3' Untranslated Regions