title: Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom.
abstract: Chemical investigation of three isolates of Penicillium crustosum Thom cultures, one of which was derived from a recent dog poisoning investigation, has led to the isolation and structure elucidation of secopenitrem D (1). Penitrems A-F and roquefortine C were also present in the isolates analyzed. The structure of 1 was unambiguously assigned based on extensive 1D and 2D-NMR spectroscopic experiments, MS-aided structural studies and by comparison with structurally related congeners. Secopenitrem D lacks the C-16-C-18 ether linkage present in penitrems A-F.
authors.affiliation: Section of Chemistry and Toxicology, National Veterinary Institute, P.O. Box 750 Sentrum, N-0106 Oslo, Norway. angel.moldes-anaya@vetinst.no
authors.forename: Angel
authors.initials: A
authors.lastname: Moldes-Anaya
authors.forename: Thomas
authors.initials: T
authors.lastname: Rundberget
authors.forename: Silvio
authors.initials: S
authors.lastname: Uhlig
authors.forename: Frode
authors.initials: F
authors.lastname: Rise
authors.forename: Alistair L
authors.initials: AL
authors.lastname: Wilkins
mesh_terms: D002851:Chromatography, High Pressure Liquid; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*
chemical_list: D026121:Indole Alkaloids; C558145:secopenitrem D