title: Suspect novel adverse drug reactions to trimethoprim-sulphonamide combinations in horses: a case series.
abstract: Adverse drug reactions to trimethoprim-sulphonamide combinations are common in many species, manifesting as gastrointestinal tract disorders, dermatopathies and blood dyscrasias. In this case series, neurological abnormalities in 4 horses being treated with trimethoprim-sulphonamide combinations at normal dosages and in one foal that received an overdose are described. The horses developed hypermetric gait, agitation and erratic behaviour. All signs resolved once medication was withdrawn, and no horse had residual deficits. No other cause for observed neurological deficits could be determined. These clinical signs appear to represent a novel adverse drug reaction to some commonly used antimicrobial combinations.
authors.affiliation: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, MI, USA. stackali@cvm.msu.edu
authors.forename: A
authors.initials: A
authors.lastname: Stack
authors.forename: H C
authors.initials: HC
authors.lastname: Schott
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000662:veterinary*; D062787:Drug Overdose; D004359:Drug Therapy, Combination; D005260:Female; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D008297:Male; D011739:Pyrimethamine / Q000008:administration & dosage / Q000009:adverse effects; D013411:Sulfadiazine / Q000008:administration & dosage / Q000009:adverse effects; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000009:adverse effects; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects*; D014295:Trimethoprim / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D013411:Sulfadiazine; D014295:Trimethoprim; D013420:Sulfamethoxazole; D011739:Pyrimethamine