title: Early left ventricular diastolic dysfunction in premature infants born to preeclamptic mothers.
abstract: To evaluate the cardiac function in premature infants born to preeclamptic mothers and its clinical consequences.
  
  
  
  This was a prospective observational cohort study performed in a tertiary neonatal intensive care unit. Fifty-three premature infants born to preeclamptic mothers comprising the study group were evaluated and compared with 42 premature infants born to normotensive mothers (control group). Relationship between echocardiographic measures and neonatal morbidity were assessed as the main outcome measures.
  
  
  
  Left ventricle end-diastolic dimension (LVEDD), peak flow velocities during early diastole (peak E wave), peak flow velocities during atrial contraction (peak A wave), and peak E/A ratio were significantly lower in the study group. Within the study group, these parameters were also significantly lower in infants with respiratory problems. LVEDD was significantly smaller in preeclamptic infants with intrauterine growth retardation (IUGR).
  
  
  
  Left ventricle diastolic dysfunction (LVDD) was detected in premature infants born to preeclamptic mothers in the first week after delivery. LVDD was associated with higher incidence of respiratory problems, transient tachypnea of the newborn, longer duration of oxygen requirement, and IUGR.
authors.affiliation: Faculty of Medicine, Division of Neonatology, Department of Pediatrics, Uludag University, Bursa, Turkey. drmerih@yahoo.com
authors.forename: Merih
authors.initials: M
authors.lastname: Cetinkaya
authors.forename: Ozlem
authors.initials: O
authors.lastname: Bostan
authors.forename: Nilgün
authors.initials: N
authors.lastname: Köksal
authors.forename: Evren
authors.initials: E
authors.lastname: Semizel
authors.forename: Hilal
authors.initials: H
authors.lastname: Ozkan
authors.forename: Seher
authors.initials: S
authors.lastname: Cakır
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D011225:Pre-Eclampsia; D011247:Pregnancy; D011446:Prospective Studies; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology*