title: Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus.
abstract: This study was aimed at examining the therapeutic effects of marine collagen peptides (MCPs) from fish hydrolysate in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 100 diabetic patients and 50 healthy controls were recruited. Diabetic patients were randomized into treatment and control groups. The patients in the treatment group received an additional 13 g of MCPs daily for 3 months. Their blood samples were collected before, and 1.5 and 3 months after, treatment to evaluate glucose and lipid metabolism. The levels of serum high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), bradykinin, prostacyclin (PGI2), and adipokines were determined. Significantly reduced levels of fasting blood glucose, human glycated hemoglobin A1c (GHbA1c), fasting blood insulin, total triglycerides, total cholesterol, low-density lipoprotein, and free-fatty acids, but increased levels of insulin sensitivity index and HDL were observed in T2DM patients following treatment with MCPs for 1.5 and 3 months. The values of these measures were significantly lower or higher than those of patient controls (p < 0.01), respectively. Interestingly, significantly decreased levels of hs-CRP and NO, but increased levels of bradykinin, PGI2, and adiponectin were detected in MCP-treated T2DM patients (p < 0.01), as compared with their basal values or the levels in patient controls. MCP treatment improved glucose and lipid metabolism in diabetic patients.
authors.affiliation: Department of Nutrition, Shenzhen Hospital of Peking University, Shenzhen 518036, China. cf-zhu@163.com
authors.forename: Cui-Feng
authors.initials: CF
authors.lastname: Zhu
authors.forename: Guan-Zhi
authors.initials: GZ
authors.lastname: Li
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Peng
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
mesh_terms: D054392:Adipokines / Q000097:blood; D000368:Aged; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D002681:China; D003094:Collagen / Q000378:metabolism / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy*; D019587:Dietary Supplements; D005260:Female; D005399:Fishes; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D011492:Protein Hydrolysates / Q000737:chemistry / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D002097:C-Reactive Protein; D003094:Collagen; D006442:Glycated Hemoglobin; D018836:Inflammation Mediators; D008055:Lipids; D009569:Nitric Oxide; D011492:Protein Hydrolysates; C517652:hemoglobin A1c protein, human