title: Asymmetric synthesis of tertiary benzylic alcohols.
abstract: Vinyl, aryl, and alkynyl organometallics add to ketones containing a stereogenic sulfoxide. Tertiary alcohols are generated in diastereomerically and enantiomerically pure form. Reductive lithiation converts the sulfoxide into a variety of useful functional groups.
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
authors.forename: Monika I
authors.initials: MI
authors.lastname: Antczak
authors.forename: Feng
authors.initials: F
authors.lastname: Cai
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Ready
mesh_terms: D001592:Benzyl Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D013237:Stereoisomerism; D013454:Sulfoxides / Q000737:chemistry*
chemical_list: D001592:Benzyl Alcohols; D007659:Ketones; D009942:Organometallic Compounds; D013454:Sulfoxides; D008094:Lithium