title: Estimation of the minimum detectable activity of preclinical PET imaging systems with an analytical method.
abstract: OBJECTIVE
  The traditional figures of merit used in the evaluation of positron emission tomography (PET) systems, including system sensitivity and spatial resolution, do not directly reflect the minimum detectable activity (MDA) performance, despite the fact that it is one of the most important tasks for a PET system. MDA, as a combination of the more traditional PET system parameters, is directly related to lesion detection. However, MDA evaluation is task specific and cannot be done by a single measurement. Therefore, a simple method to evaluate system detectability needs to be developed.
  
  
  METHODS
  In this work, an analytical method of MDA estimation was developed, taking into account system sensitivity, spatial resolution, source properties, and noise propagation in image reconstruction by using the Rose criterion and/or the Curie equation as the detection standard. In the implementation, the source background, as well as the intrinsic activity background from the scintillation material of the system, was also taken into consideration. The accuracy of this method was evaluated in two commercially available preclinical PET systems, with phantom experiments that were designed to closely mimic in vivo tumor uptake without introducing finite boundaries between the source and the background.
  
  
  RESULTS
  The lesion contrast-to-noise ratio calculated by the analytical evaluation showed good agreement with that obtained from the experiments. Visual assessment of the reconstructed images at the detection limit (based on analytical evaluation) also was in agreement with the Rose criterion. The MDA performance was quantitatively compared between the two preclinical PET systems and showed different detection limits under different imaging conditions, suggesting that the detection limit of a PET system strongly depends on the lesion properties and acquisition settings.
  
  
  CONCLUSIONS
  An analytical method of evaluating the PET system detectability was developed and validated by experiments. Overall, the analytical MDA calculation provides a simple way to evaluate the signal detectability of a PET system and can be used for comparing different systems. It also provides guidelines for designing new PET tomographs as well as optimizing data acquisition protocols.
authors.affiliation: Department of Molecular and Medical Pharmacology, The Crump Institute for Molecular Imaging, David Geffen School of Medicine at UCLA, 570 Westwood Plaza, Bldg. 114, Los Angeles, California 90095, USA. qbao@mednet.ucla.edu
authors.forename: Qinan
authors.initials: Q
authors.lastname: Bao
authors.forename: Arion F
authors.initials: AF
authors.lastname: Chatziioannou
mesh_terms: D000465:Algorithms; D000818:Animals; D002138:Calibration; D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D015233:Models, Statistical; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000494:pharmacology; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals