title: [Multivariate genetic analysis of canine hip and elbow dysplasia as well as humeral osteochondrosis in the Bernese mountain dog].
abstract: In the present study genetic parameters for canine hip dysplasia (CHD), canine elbow dysplasia (CED) and osteochondrosis dissecans of the humeral head (OCD) were analysed in Bernese mountain dogs. The data set included the official scores for CHD and CED from 5534 Bernese mountain dogs born in the years 1995-2008. A multivariate linear animal model was employed to estimate heritabilities, additive genetic and residual correlations using residual maximum likelihood (REML). Heritability estimates were h2 = 0.26 for CHD, h2 = 0.22 for CED and h2 = 0.40 for OCD. The additive genetic correlation between CHD and CED was 0.31, between CHD and OCD 0.25, and between CED und OCD -0.49. A further multivariate analysis of the prevalence of the FCP (fragmented coronoid processus), CHD and OCD revealed a heritability of h2 = 0.59 for FCP. The additive genetic correlations among FCP and CHD as well CED except FCP were positive, but negative with OCD. Multivariately estimated breeding values will lead to higher genetic progress because the correlation structure of the traits can be taken into account and possible genetic antagonisms among traits are better reflected in the breeding values.
authors.affiliation: Institut für Tierzucht und Vererbungsforschung, Stiftung Tierärztliche Hochschule Hannover.
authors.forename: Peter
authors.initials: P
authors.lastname: Hartmann
authors.forename: Kathrin Friederike
authors.initials: KF
authors.lastname: Stock
authors.forename: Ottmar
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs / Q000235:genetics*; D005552:Forelimb / Q000473:pathology; D005858:Germany / Q000453:epidemiology; D006614:Hindlimb / Q000473:pathology; D006619:Hip Dysplasia, Canine / Q000453:epidemiology / Q000235:genetics*; D006811:Humerus / Q000473:pathology; D015994:Incidence; D016013:Likelihood Functions; D015999:Multivariate Analysis