title: Ipomoea batatas attenuates amyloid β peptide-induced neurotoxicity in ICR mice.
abstract: In this study, the protective effects of 17 Korean native plants against amyloid β peptide (Aβ)-induced oxidative stress were screened using the 2',7'-dichlorofluorescin diacetate assay and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Ipomoea batatas exerted the highest protective effects against oxidative stress and was selected for further investigation. To confirm the protective activity of this extract, the I. batatas extract was fed to ICR mice that had been injected with Aβ to induce neuronal deficits. In these experiments, the extract of I. batatas significantly reversed Aβ-induced neurotoxicity as assessed by the passive avoidance test, a behavioral experiment. Moreover, I. batatas administration reduced the level of lipid peroxidation and increased catalase activities in biochemical studies using the brain tissue of mice. These results indicate that I. batatas might be beneficial against Alzheimer's disease, especially by limiting oxidative stress in the brain.
authors.affiliation: Department of Food and Biotechnology, Korea University, Seoul, Republic of Korea.
authors.forename: Jae Kyeom
authors.initials: JK
authors.lastname: Kim
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Choi
authors.forename: Hong Yon
authors.initials: HY
authors.lastname: Cho
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kim
authors.forename: Seung-Taik
authors.initials: ST
authors.lastname: Lim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
authors.forename: Eun Ki
authors.initials: EK
authors.lastname: Kim
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Sabrina
authors.initials: S
authors.lastname: Peterson
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
mesh_terms: D016229:Amyloid beta-Peptides / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D027723:Ipomoea batatas; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D010936:Plant Extracts; D002374:Catalase