title: Acute myeloid leukemia associated with t(1;3)(p36;q21) and extreme thrombocytosis: a clinical study with literature review.
abstract: We present an unusual case study on acute myeloid leukemia associated with t(1;3) and extreme thrombocytosis, along with a thorough review on relevant literature of t(1;3) cases (58 patients). On the basis of this study and literature review, thrombocytosis (>400,000/μL) is a relatively common finding in one third of patients with t(1;3), whereas increase of platelet count by more than 1,000,000/μL is an extremely rare phenomenon, even among patients with t(1;3). To our knowledge, this study is the only documented case that recorded more than 2,000,000/μL of extreme thrombocytosis in a de novo acute myeloid leukemia patient with t(1;3) at initial diagnosis. Because only a few patients with t(1;3) responded to conventional chemotherapy, more aggressive therapy such as stem-cell transplantation should be considered to improve patient survival in t(1;3) cases.
authors.affiliation: Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea.
authors.forename: Gayoung
authors.initials: G
authors.lastname: Lim
authors.forename: Min Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Oh
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Cho
authors.forename: Hee Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jin-Tae
authors.initials: JT
authors.lastname: Suh
authors.forename: Juhie
authors.initials: J
authors.lastname: Lee
authors.forename: Woo-In
authors.initials: WI
authors.lastname: Lee
authors.forename: Kyung Sam
authors.initials: KS
authors.lastname: Cho
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology; D002878:Chromosomes, Human, Pair 1; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D013922:Thrombocytosis / Q000235:genetics*; D014178:Translocation, Genetic