title: Clinical xenotransplantation.
abstract: Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies to deal with this problem are discussed.
authors.affiliation: Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.A.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Starzl
authors.forename: Noriko
authors.initials: N
authors.lastname: Murase
authors.forename: Andreas
authors.initials: A
authors.lastname: Tzakis
authors.forename: John J
authors.initials: JJ
authors.lastname: Fung
authors.forename: Satoru
authors.initials: S
authors.lastname: Todo
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Demetris
authors.forename: Rafael
authors.initials: R
authors.lastname: Manez
authors.forename: Ignazio R
authors.initials: IR
authors.lastname: Marino
authors.forename: Luis
authors.initials: L
authors.lastname: Valdivia