title: Effects of cholinergic agonists and antagonists under conditions of spleen denervation in rats with endotoxic shock.
abstract: Model experiments on rats with endotoxic shock induced by intraperitoneal injection of LPS Salmonella Typhi strain ty-4441 (20 mg/kg) showed that crossing of the vagus nerve innervating the spleen increased HR, stimulated production of antibodies, and moderated serotonergic activity of splenocytes. Pharmacological correction of the shock with muscarinic receptor antagonist atropine and its combinations with anticholinesterase agent galantamine or muscarinic and nicotinic cholinoreceptor agonist choline alfoscerate 30 min before shock modeling moderated HR and normalized B cell functions and serotonin level in the spleen.
authors.affiliation: S. V. Anichkov Department of Neuropharmacology, Research Institute of Experimental Medicine, NorthWestern Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia.
authors.forename: N S
authors.initials: NS
authors.lastname: Sapronov
authors.forename: G I
authors.initials: GI
authors.lastname: Nezhinskaya
authors.forename: A L
authors.initials: AL
authors.lastname: Vladykin
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology*; D003714:Denervation; D005702:Galantamine / Q000494:pharmacology; D005997:Glycerylphosphorylcholine; D006339:Heart Rate / Q000187:drug effects; D009241:Ipratropium / Q000494:pharmacology; D008070:Lipopolysaccharides; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012485:Salmonella typhi / Q000276:immunology; D012701:Serotonin / Q000378:metabolism; D012772:Shock, Septic / Q000276:immunology; D013154:Spleen / Q000294:innervation*
chemical_list: D018679:Cholinergic Agonists; D008070:Lipopolysaccharides; D018727:Muscarinic Antagonists; D018722:Nicotinic Agonists; D005702:Galantamine; D012701:Serotonin; D005997:Glycerylphosphorylcholine; D001285:Atropine; D009241:Ipratropium