title: Role of nitric oxide in activity control of mechanically gated ionic channels in cardiomyocytes: NO-donor study.
abstract: Whole-cell ionic currents through mechanically gated channels (MGC) were recorded in isolated cardiomyocytes under voltage clamp conditions. In unstrained cells, NO donors SNAP and DEA-NO activated MGC and induced MG-like currents. In contrast, in stretched cells with activated MGC, these NO-donors inactivated and inhibited MGC.
authors.affiliation: Department of Fundamental and Applied Physiology, Medico-Biological Faculty, N. I. Pirogov Russian State Medical University, Moscow, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Kazanski
authors.forename: A G
authors.initials: AG
authors.lastname: Kamkin
authors.forename: E Yu
authors.initials: EY
authors.lastname: Makarenko
authors.forename: N N
authors.initials: NN
authors.lastname: Lysenko
authors.forename: P V
authors.initials: PV
authors.lastname: Sutiagin
authors.forename: Tian
authors.initials: T
authors.lastname: Bo
authors.forename: I S
authors.initials: IS
authors.lastname: Kiseleva
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006168:Guinea Pigs; D006834:Hydrazines / Q000494:pharmacology; D015640:Ion Channel Gating / Q000187:drug effects*; D007473:Ion Channels / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D026423:S-Nitroso-N-Acetylpenicillamine / Q000494:pharmacology
chemical_list: D006834:Hydrazines; D007473:Ion Channels; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D026423:S-Nitroso-N-Acetylpenicillamine; C084012:1,1-diethyl-2-hydroxy-2-nitrosohydrazine