title: [The vasodilation and its mechanism of C-type natriuretic peptide].
abstract: OBJECTIVE
  With routine blood vessel perfusion in vitro, the vasodilation and its mechanism of C-type natriuretic peptide, a new member of natriuretic peptide family were observed in rabbits.
  
  
  RESULTS
  CNP had the dose-dependent vasodilation effects on abdominal artery and celiac vein at the range of 10(-10)-10(-6) mol/L, its action on vein was just like nitroglycerin, its action on artery was weaker than that of ANP. Atropine (10(-7) mol/L), Regitine (20 microg), and indomethacin (20 microg) had nothing effect on the vasodilation of CNP on abdominal artery. But glibenclamide (10(-6) mol/L) and propranolol (10(-6) mol/L) could decrease the vasodilation of CNP obviously, in addition, CNP couldn't inhibit the vasoconstriction of NE.
  
  
  CONCLUSIONS
  (1) CNP might be kind of venous systemic vasodilator, and it was also a arterial selective peptide controlling the vessel tone. (2) CNP dilated the vessel at least through two ways: (a) ATP-sensitive K+ channel, (b) beta-receptor.
authors.affiliation: Department of Physioligy, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Wang
authors.forename: J M
authors.initials: JM
authors.lastname: Pei
authors.forename: M Z
authors.initials: MZ
authors.lastname: Zhu
authors.forename: Y M
authors.initials: YM
authors.lastname: Zang
authors.forename: M Z
authors.initials: MZ
authors.lastname: Li
authors.forename: G B
authors.initials: GB
authors.lastname: Nui
authors.forename: F
authors.initials: F
authors.lastname: Shi
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D020098:Natriuretic Peptide, C-Type / Q000494:pharmacology*; D011817:Rabbits; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D020098:Natriuretic Peptide, C-Type