title: Spirocurcasone, a diterpenoid with a novel carbon skeleton from Jatropha curcas.
abstract: Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano, 49, I-80131 Napoli, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Chianese
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Olapeju O
authors.initials: OO
authors.lastname: Aiyelaagbe
authors.forename: Paolo
authors.initials: P
authors.lastname: Luciano
authors.forename: Heinz C
authors.initials: HC
authors.lastname: Schröder
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D031286:Jatropha / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C556077:spirocurcasone