title: Kinesigenic dyskinesia in a case of voltage-gated potassium channel-complex protein antibody encephalitis.
abstract: OBJECTIVE
  To describe the first case (to our knowledge) of voltage-gated potassium channel-complex protein antibody encephalitis with kinesigenic dyskinesia and cramp-fasciculation syndrome.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Hospitalized care.
  
  
  METHODS
  A 38-year-old man with a history of bronchial asthma, eczema, vitiligo, and immune complex mesangiopathic glomerulonephritis presented with abnormal movements.
  
  
  METHODS
  Clinical examination, magnetic resonance imaging, single-photon emission computed tomography, electromyography and nerve conduction studies, video-electroencephalographic monitoring, plasmapheresis exchange therapy, and intravenous immunoglobulin administration.
  
  
  RESULTS
  Clinical examination revealed paroxysmal kinesigenic dyskinesia and fasciculations. Magnetic resonance imaging of the brain revealed a left caudate and left putamen increased signal lesion on T2-weighted and fluid-attenuated inversion recovery sequences as well as increased flow in the same region on single-photon emission computed tomographic scans. Electromyography and nerve conduction studies revealed significant afterdischarges, cramp potentials, and continuous motor activity. The video-electroencephalographic monitoring revealed no epileptiform discharges. The patient dramatically improved after 5 plasmapheresis exchange treatments and a course of intravenous immunoglobulin at 2 gm/kg over 5 divided doses.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of paroxysmal kinesigenic dyskinesia with voltage-gated potassium channel-complex protein antibody encephalitis associated with the cramp fasciculation syndrome.
authors.affiliation: Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102-1192, USA.
authors.forename: Enrique
authors.initials: E
authors.lastname: Aradillas
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Schwartzman
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis*; D020820:Dyskinesias / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D004679:Encephalomyelitis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D008297:Male; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated