title: Flow-orthogonal bead oscillation in a microfluidic chip with a magnetic anisotropic flux-guide array.
abstract: A new concept for the manipulation of superparamagnetic beads inside a microfluidic chip is presented in this paper. The concept allows for bead actuation orthogonal to the flow direction inside a microchannel. Basic manipulation functionalities were studied by means of finite element simulations and results were oval-shaped steady state oscillations with bead velocities up to 500 μm/s. The width of the trajectory could be controlled by prescribing external field rotation. Successful verification experiments were performed on a prototype chip fabricated with excimer laser ablation in polycarbonate and electroforming of nickel flux-guides. Bead velocities up to 450 μm/s were measured in a 75 μm wide channel. By prescribing the currents in the external quadrupole magnet, the shape of the bead trajectory could be controlled.
authors.affiliation: Department of Mechanical Engineering, Micro- and NanoScale Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. s.v.pelt@tue.nl
authors.forename: Stijn
authors.initials: S
authors.lastname: van Pelt
authors.forename: Roy
authors.initials: R
authors.lastname: Derks
authors.forename: Marco
authors.initials: M
authors.lastname: Matteucci
authors.forename: Mikkel Fougt
authors.initials: MF
authors.lastname: Hansen
authors.forename: Andreas
authors.initials: A
authors.lastname: Dietzel
mesh_terms: D016880:Anisotropy; D008280:Magnetics; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008863:Microspheres; D009038:Motion; D011076:Polycarboxylate Cement / Q000737:chemistry
chemical_list: D011076:Polycarboxylate Cement; C005506:polycarbonate