title: Seroepidemiology of Dengue virus in Mayotte, Indian Ocean, 2006.
abstract: BACKGROUND
  Although Dengue virus (DENV) circulation had been documented in neighbouring South-western Indian Ocean Islands, its presence in Mayotte is poorly characterised. To address this issue, we aimed to assess the seroprevalence of dengue IgG antibodies (DENV-IgG Ab) among the population and to investigate potential associations with individual and household characteristics.
  
  
  RESULTS
  In November-December 2006 we conducted a cross-sectional serologic survey in Mayotte among 1,154 inhabitants aged≥2 years by using a multistage cluster random sampling method. The overall prevalence of DENV-specific IgG antibodies (ELISA) was 22.73% (95% CI, 18.16-27.31). The age-specific seroprevalence increased with age (χ2 for trend=11.86, P<0.0006), and was linked with previous known outbreaks in this region. In multivariate analysis, older age, being born in the Comoros and living in a household with a low socioeconomic index were positively associated with DENV IgG antibody positivity.
  
  
  CONCLUSIONS
  These findings document substantial prior exposure of the population of Mayotte to DENV and highlight the risk of severe illness due to the possibility of sequential DENV infections. Further investigations characterizing current DENV circulation patterns and associated serotypes are needed.
authors.affiliation: Université Victor Segalen Bordeaux 2, Centre René Labusquière, and Centre Hospitalier Universitaire, Service de Dermatologie, Hôpital Saint André, Bordeaux, France.
authors.forename: Daouda
authors.initials: D
authors.lastname: Sissoko
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
authors.forename: Claude
authors.initials: C
authors.lastname: Giry
authors.forename: Amrat
authors.initials: A
authors.lastname: Moendandzé
authors.forename: Tinne
authors.initials: T
authors.lastname: Lernout
authors.forename: Eric
authors.initials: E
authors.lastname: D'Ortenzio
authors.forename: François
authors.initials: F
authors.lastname: Pettinelli
authors.forename: Denis
authors.initials: D
authors.lastname: Malvy
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D017507:Comoros / Q000453:epidemiology; D003715:Dengue / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D005191:Family Characteristics; D005260:Female; D005843:Geography; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G