title: Regulation of protein function by 'microProteins'.
abstract: Many proteins achieve their function by acting as part of multi-protein complexes. The formation of these complexes is highly regulated and mediated through domains of protein-protein interaction. Disruption of a complex or of the ability of the proteins to form homodimers, heterodimers or multimers can have severe consequences for cellular function. In this context, the formation of dimers and multimers can be perturbed by proteins referred to here as 'microProteins'. These disruptive protein species contain the protein-interaction domains of bona fide interaction partners, but lack the functional domains required for the activation of, for example, transcription or DNA binding. MicroProteins thus behave as post-translational regulators by forming homotypic dimers with their targets, and act through the dominant-negative suppression of protein complex function. Although the first microProtein was identified more than two decades ago, the recent discovery and characterization of three further small protein species in plants emphasizes their importance. The studies discussed in this review demonstrate that the action of microProteins is general and that it has evolved in both the animal and the plant kingdoms.
authors.affiliation: Centre for Plant Molecular Biology, University of Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
authors.forename: Annica-Carolin
authors.initials: AC
authors.lastname: Staudt
authors.forename: Stephan
authors.initials: S
authors.lastname: Wenkel
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D057906:Circadian Clocks / Q000502:physiology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D016350:Leucine Zippers; D046912:Multiprotein Complexes / Q000502:physiology*; D010937:Plant Growth Regulators / Q000502:physiology; D010940:Plant Proteins / Q000502:physiology; D054730:Protein Interaction Domains and Motifs; D055503:Protein Multimerization / Q000502:physiology*
chemical_list: D018398:Homeodomain Proteins; D046912:Multiprotein Complexes; D010937:Plant Growth Regulators; D010940:Plant Proteins