title: Involvement of bone-marrow-derived cells in kidney fibrosis.
abstract: Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generation of matrix-producing cells in diseased kidneys have been categorized as activated resident stromal cells (e.g., fibroblasts, pericytes), infiltrating bone-marrow-derived cells (e.g., fibrocytes, T cells, macrophages), and cells derived from epithelial-mesenchymal transition/endothelial-mesenchymal transition. Among these cell sources, accumulating evidence has shed light on the involvement of bone-marrow-derived cells, including monocytes/macrophages, and a circulating mesenchymal progenitor cell, fibrocyte, in the progression of fibrosis in kidney. Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin-angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis.
authors.affiliation: Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. twada@m-kanazawa.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
authors.forename: Norihiko
authors.initials: N
authors.lastname: Sakai
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Sakai
authors.forename: Kouji
authors.initials: K
authors.lastname: Matsushima
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
authors.forename: Kengo
authors.initials: K
authors.lastname: Furuichi
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D001854:Bone Marrow Cells / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D005355:Fibrosis; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000473:pathology; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000473:pathology; D009000:Monocytes / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology; D017154:Stromal Cells / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D018925:Chemokines; D024042:Collagen Type I; D017493:Leukocyte Common Antigens