title: [Changes of renal cortex lipid peroxidation in renal injury induced by cisplatin in rats].
abstract: OBJECTIVE
  To study the relativity of the renocortical lipid peroxidation with renal tubules structure damage in renal injury induced by cisplatin in rats.
  
  
  METHODS
  Female Wistar rats were randomly divided into NS group, CDDP(I) group, CDDP(II) group and CDDP(III) group. All rats were injected via the tail vein with NS or cisplatin and NS qd in five days. The changes in content of Scr, BUN and MDA, the activity of SOD and GSH-Px of the renal cortex were measured. Alkaline phosphatase of renal tubular epithelia was stained by histochemistry and the slices of renal cortex were observed.
  
  
  RESULTS
  The contents of Scr and BUN of CDDP groups were significantly higher than those of NS group (P < 0.01). The content of renocortical MDA was significantly higher than that of NS group (P < 0.05). The activities of renoconical SOD and GSH-Px were lower than those of NS group (P < 0.05). The content of MDA, activities of renocortical SOD and GSH-Px with the content of Scr and BUN were significantly correlative. Alkaline phosphatase of renal tubular epithelia cells was losed largely and renal tubular epithelia cells were denaturative and necrotic partly in sections.
  
  
  CONCLUSIONS
  The damage of renal cortex was correlative with its lipid peroxidation. The injury of renal cortex became heavier with cisplatin dose increased.
authors.affiliation: Department of Pathophysiology, Henan Medical College For Staff and Workers, Zhengzhou 450003, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Pei
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Xing-Fen
authors.initials: XF
authors.lastname: Gui
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D007672:Kidney Cortex / Q000187:drug effects* / Q000503:physiopathology*; D007684:Kidney Tubules / Q000473:pathology; D015227:Lipid Peroxidation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002945:Cisplatin