title: Enantioselective rhodium-catalyzed C-C bond activations.
abstract: The catalytic activation of carbon-carbon single bonds represents a major challenge in organometallic chemistry. Strained ring substrates occupy in this respect a privileged role as their inherent ring strain facilitates the desired metal insertion. Employing symmetrically substituted tert-cyclobutanols, an enantioselective rhodium(I)-catalyzed beta-carbon elimination creates alkyl-rhodium species bearing all-carbon quaternary stereogenic centers. Downstream reactions enable access to a wide range of synthetically versatile products such as substituted cyclohexenones, lactones and indanols with excellent enantioselectivities of up to 99% ee.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich.
authors.forename: Tobias
authors.initials: T
authors.lastname: Seiser
authors.forename: Nicolai
authors.initials: N
authors.lastname: Cramer