title: Rhinologic and sinonasal changes in PR3 ANCA pulmonary vasculitis.
abstract: BACKGROUND
  Over 70-95% patients with PR3 ANCA pulmonary vasculitis present with upper respiratory tract symptoms or sings. Nasal cavity usually presents with obstruction and chronic refractory infections (rhinosinusitis) which commonly manifest as bloody discharge or crusting obstruction. Mucopurulent discharge may occur in the acute phase or remission, along with other symptoms suggesting sinusitis. Later on, saddle nose deformities can occur due to collapse of the nasal septum. Other common destruction areas are the maxillary ostia, erosion of the tubinates or damage of soft palate.
  
  
  OBJECTIVE
  The aim of the study was to characterize pathologies of nasal and sinonasal CT scans in patients with PR3 pulmonary ANCA vasculitis and to establish the CT diagnostic criteria for WG. Between 2005-2009 sinonasal CT visualization was performed in 35 patients (19 female, 16 male) with PR3 ANCA positive WG.
  
  
  RESULTS
  Bony destruction of the nasal cavity was revealed in 15 (42.8%), damage or distortion of the paranasal sinuses in 20 (57.1%), the mastoid cells in 7 (20%), and the orbits in 7 (20%) patients. Sclerosing osteitis of the nasal cavity and paranasal sinuses were observed in 11 (31.4%) and in 24 (68.5%), respectively. Bony thickening of the nasal cavity was shown in 5 (14.2%) patients and of the paranasal sinuses in 7 (20%) (unilateral in 2 and bilateral in 5 patients). Seven patients (20%) had orbital masses; all unilateral. Septal perforation was observed in 11 (31.4%) and saddle nose deformity in 7 (20%) patients.
  
  
  CONCLUSIONS
  Maxillary sinuses are regions which are most frequently affected during the course of PR3 ANCA pulmonary vasculitis. CT imagines may be a useful supplement to clinical and activity scoring of WG disease with pulmonary involvement.
authors.affiliation: Department of Family Medicine, Internal and Metabolic Diseases, Warsaw Medical University, Warsaw, Poland. kzycinska@poczta.fm
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zycinska
authors.forename: K A
authors.initials: KA
authors.lastname: Wardyn
authors.forename: E
authors.initials: E
authors.lastname: Piotrowska
authors.forename: T M
authors.initials: TM
authors.lastname: Zielonka
authors.forename: H
authors.initials: H
authors.lastname: Zycinski
authors.forename: A
authors.initials: A
authors.lastname: Bogaczewicz
authors.forename: A
authors.initials: A
authors.lastname: Nitsch-Osuch
authors.forename: M
authors.initials: M
authors.lastname: Miskiewicz
authors.forename: R
authors.initials: R
authors.lastname: Smolarczyk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology*; D010256:Paranasal Sinuses / Q000473:pathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic