title: Peritoneal carcinomatosis of colorectal origin.
abstract: Peritoneal carcinomatosis is, after liver metastases, the second most frequent cause of death in colorectal cancer patients and at the present time, is commonly inserted and treated as a stage IV tumour. Because there is no published data that outlines the impact of new therapeutic regimens on survival of patients with peritoneal surface diffusion, the story of carcinomatosis can be rewritten in light of a new aggressive approach based on the combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Also if these treatment perhaps allow to obtain better results than standard therapies, we suggest, that a large prospective randomised control trial is needed to compare long-term and progression-free survival under the best available systemic therapy with or without cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
authors.affiliation: Antonio Macrì, Edoardo Saladino, Vincenzo Bartolo, Ciro Famulari, University of Messina, Department of Human Pathology, General Surgery Unit, 98125 Messina, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Macrì
authors.forename: Edoardo
authors.initials: E
authors.lastname: Saladino
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bartolo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Adamo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Altavilla
authors.forename: Epifanio
authors.initials: E
authors.lastname: Mondello
authors.forename: Giovanni
authors.initials: G
authors.lastname: Condemi
authors.forename: Angelo
authors.initials: A
authors.lastname: Sinardi
authors.forename: Ciro
authors.initials: C
authors.lastname: Famulari