title: Can breast magnetic resonance imaging demonstrate characteristic findings of preoperative ductal carcinoma in situ in Taiwanese women?
abstract: OBJECTIVE
  Magnetic resonance imaging (MRI) is more sensitive than mammography and sonography for breast cancer detection, but its diagnostic specificity is still being debated, and standardised criteria are lacking.
  
  
  METHODS
  This study used a dedicated breast MRI system with a Spiral RODEO pulse sequence, and applied postprocessing techniques including multiplanar reformation (MPR) with ductal orientation, early subtracted phase (ESP) and a postcontrast kinetic curve. We discuss the possible MRI/pathology correlations based on pathogenetic concepts. We retrospectively collected data from 13 cases of benign intraductal and early-stage malignant lesions to observe the capability of MPR, ESP and kinetic curve techniques to diagnose early lesions differentially. MRI features and pathological findings for these cases were collected.
  
  
  RESULTS
  Thirteen cases of ductal carcinoma in situ with MRI characteristics and pathological findings were identified. We analysed early ductal lesions, such as intraductal epithelial hyperplasia, intraductal papilloma, ductal carcinoma in situ and small focal invasive ductal carcinoma. Using MRI with MPR to demonstrate ductal orientation, we found 12 cases with a ductogram appearance and 6 with crossing-over glandular tissue. The tumour size estimated by MRI was accurate in 6 cases, but overestimated in seven.
  
  
  CONCLUSIONS
  Dedicated breast MRI with MPR, ESP and kinetic curve analyses might be helpful in defining some characteristics of early-stage malignant lesions.
authors.affiliation: Department of Diagnostic Radiology, Taipei Medical University Hospital, No. 2523 Wu Hsing Street, Taipei 110, Taiwan. hk8648@ms9.hinet.net
authors.forename: Ting-Kai
authors.initials: TK
authors.lastname: Leung
authors.forename: Pai-Jung
authors.initials: PJ
authors.lastname: Huang
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Lee
authors.forename: Ching-Shyang
authors.initials: CS
authors.lastname: Chen
authors.forename: Chih-Hsiung
authors.initials: CH
authors.lastname: Wu
authors.forename: Jo-Shui
authors.initials: JS
authors.lastname: Chao
mesh_terms: D000328:Adult; D044466:Asian People; D001943:Breast Neoplasms / Q000208:ethnology* / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000208:ethnology* / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008408:Mastectomy; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013624:Taiwan