title: Thermal cleavage of the fmoc protection group.
abstract: The Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.
authors.affiliation: ZHAW Zurich University of Applied Sciences, Institute of Chemistry and Biological Chemistry (ICBC), Campus Reidbach, Einsiedlerstrasse 31, CH-8820 Wädenswil. stefan.hoeck@zhaw.ch
authors.forename: Stefan
authors.initials: S
authors.lastname: Höck
authors.forename: Roger
authors.initials: R
authors.lastname: Marti
authors.forename: Rainer
authors.initials: R
authors.lastname: Riedl
authors.forename: Marina
authors.initials: M
authors.lastname: Simeunovice
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides