title: A therapeutic target for smoking-associated lung cancer.
abstract: A report in this issue of Science Translational Medicine reveals that amplification of the FGFR1 gene-which encodes fibroblast growth factor receptor 1-is a major oncogenic aberration in squamous cell lung cancer. This genetic variation may represent the first relatively high-frequency therapeutic target of smoking-associated lung cancer.
authors.affiliation: Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK. nicholas.turner@icr.ac.uk
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Turner
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Seckl
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D000077192:Adenocarcinoma of Lung; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011743:Pyrimidines / Q000627:therapeutic use; D034622:RNA Interference; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: D004791:Enzyme Inhibitors; C115711:PD 173074; D011743:Pyrimidines; D051496:Receptor, Fibroblast Growth Factor, Type 1