title: Tarka® overdose in a young child.
abstract: Tarka® is a combination antihypertensive medication composed of verapamil hydrochloride and trandolapril. A 3.5-year-old female was brought to our hospital due to a sleepy condition 7 hours after an accidental ingestion of six tablets of Tarka® containing 240 mg verapamil hydrochloride and 4 mg trandolapril in each tablet. Five hours after hospitalization, her condition deteriorated and arterial pressure progressively decreased despite the treatment. Finally, a temporary pacemaker was implanted, after which the vital findings began to return to normal values. The pacemaker was removed 13 hours after implantation as normal heart rhythm was observed. There are no reports of intoxication with fixed-dose combination products, especially Tarka®, in young children in the literature. Therefore, we believe that our report can provide an insight on the toxic dose of this drug in younger children. Clinicians should keep in mind that lethargy can be the first symptom of a possible clinical deterioration, even in normotensive and normorhythmic individuals.
authors.affiliation: Department of Pediatrics, Yuzuncu Yil University, School of Medicine, Van, Türkiye. doganmurat.md@gmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Doğan
authors.forename: Murat
authors.initials: M
authors.lastname: Basaranoglu
authors.forename: Erdal
authors.initials: E
authors.lastname: Peker
authors.forename: Sinan
authors.initials: S
authors.lastname: Akbayram
authors.forename: Musa
authors.initials: M
authors.lastname: Sahin
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Uner
authors.forename: Huseyin
authors.initials: H
authors.lastname: Caksen
mesh_terms: D002675:Child, Preschool; D004338:Drug Combinations; D062787:Drug Overdose / Q000175:diagnosis / Q000628:therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000506:poisoning*; D010138:Pacemaker, Artificial; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D004338:Drug Combinations; D007211:Indoles; C052035:trandolapril; D014700:Verapamil