title: Accelerating the discovery of new drug targets with chemical proteomics.
abstract: The application of chemical proteomics to new target discovery can lead to a rapid understanding of disease mechanism and new therapeutic methods. Successful application includes a thorough understanding of SAR and the validation of target relevance using multiple genetic and biochemical methods. This feature review highlights several successful applications of chemical proteomics and outlines the strategy and approaches that lead to the discovery of novel therapeutic targets.
authors.affiliation: Novartis Institutes for BioMedical Research, Global Discovery Chemistry-Chemogenetics and Proteomics, 250 Massachusetts Aveune, Cambridge, MA 02139, USA. atwood.cheung@novartis.com
authors.forename: Atwood K
authors.initials: AK
authors.lastname: Cheung
authors.forename: Rishi K
authors.initials: RK
authors.lastname: Jain
mesh_terms: D000818:Animals; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004345:Drug Industry / Q000379:methods; D006801:Humans; D058990:Molecular Targeted Therapy; D010600:Pharmacology / Q000379:methods*; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship