title: Can calcium, phosphate, calcium phosphate product and intact parathyroid hormone levels be appropriately controlled in dialysis patients?
abstract: OBJECTIVE
  To review the target levels of calcium (Ca), phosphate (P), calcium phosphate products (Ca × P) and intact parathyroid hormone (iPTH) levels in patients undergoing hemodialysis (HD) and peritoneal dialysis (PD) and compare them with the Kidney Disease Outcome Quality Initiative (K/DOQI) recommendations.
  
  
  METHODS
  Three hundred and fifty-seven patients who had been undergoing dialysis for more than 3 months were included. Patients who had undergone a parathyroidectomy were excluded. The levels of Ca, P, iPTH and Ca × P were monitored for the last 3 months. The Ca and P levels were measured by standard techniques, and iPTH was assessed by the intact molecule assay.
  
  
  RESULTS
  Between HD and PD patients, there was no statistically significant difference for age, duration of dialysis or primary disease causing end-stage renal disease. The percentage of patients whose serum Ca, P, Ca × P product and iPTH were within K/DOQI recommended target ranges were 61.2, 66.4, 82.2 and 28.3% in HD patients, and 56.3, 60.6, 85.9 and 22.5% in PD patients, respectively. When all results for each group - HD and PD - were analyzed, 12.8% of patients had all 4 markers within the target range.
  
  
  CONCLUSIONS
  Achieving target ranges of mineral markers is important in dialysis patients, but reaching K/DOQI target levels is difficult. Hence, physicians should be careful in using P binders and vitamin D analogs to achieve the normal ranges.
authors.affiliation: Department of Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey. serpilmugedeger@yahoo.com
authors.forename: S M
authors.initials: SM
authors.lastname: Deger
authors.forename: R
authors.initials: R
authors.lastname: Mutluay
authors.forename: U
authors.initials: U
authors.lastname: Derici
authors.forename: F
authors.initials: F
authors.lastname: Mandiralioglu
authors.forename: T
authors.initials: T
authors.lastname: Arinsoy
authors.forename: S
authors.initials: S
authors.lastname: Sindel
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood*; D002130:Calcium Phosphates / Q000097:blood*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010530:Peritoneal Dialysis; D010710:Phosphates / Q000097:blood*; D012016:Reference Values; D006435:Renal Dialysis; D012189:Retrospective Studies; D018434:Sickness Impact Profile; D014421:Turkey
chemical_list: D002130:Calcium Phosphates; D010281:Parathyroid Hormone; D010710:Phosphates; C020243:calcium phosphate; D002118:Calcium