title: Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles.
abstract: A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP.
authors.affiliation: The Third Affiliated Hospital of Sun-Yat-Sen University, Guangzhou, China.
authors.forename: Jun-Sheng
authors.initials: JS
authors.lastname: Zheng
authors.forename: Shan-Yuan
authors.initials: SY
authors.lastname: Zheng
authors.forename: Yi-Bo
authors.initials: YB
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zheng
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012643:Selenium / Q000378:metabolism* / Q000494:pharmacology*; D013499:Surface Properties / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D019158:N-Acetylneuraminic Acid; D012643:Selenium