title: Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype.
abstract: The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB-TolC (Enterobacteriaceae) and MexAB-OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products.
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
authors.forename: V
authors.initials: V
authors.lastname: Kuete
authors.forename: S
authors.initials: S
authors.lastname: Alibert-Franco
authors.forename: K O
authors.initials: KO
authors.lastname: Eyong
authors.forename: B
authors.initials: B
authors.lastname: Ngameni
authors.forename: G N
authors.initials: GN
authors.lastname: Folefoc
authors.forename: J R
authors.initials: JR
authors.lastname: Nguemeving
authors.forename: J G
authors.initials: JG
authors.lastname: Tangmouo
authors.forename: G W
authors.initials: GW
authors.lastname: Fotso
authors.forename: J
authors.initials: J
authors.lastname: Komguem
authors.forename: B M W
authors.initials: BM
authors.lastname: Ouahouo
authors.forename: J-M
authors.initials: JM
authors.lastname: Bolla
authors.forename: J
authors.initials: J
authors.lastname: Chevalier
authors.forename: B T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: A E
authors.initials: AE
authors.lastname: Nkengfack
authors.forename: J-M
authors.initials: JM
authors.lastname: Pagès
mesh_terms: D000470:Alkaloids / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D001692:Biological Transport; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D010636:Phenols / Q000378:metabolism / Q000494:pharmacology; D013729:Terpenes / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001688:Biological Products; D026901:Membrane Transport Proteins; D010636:Phenols; D013729:Terpenes