title: 2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dimethylaminomethyl cyclohexanone hydrochloride: a Mannich base which inhibits the growth of some drug-resistant strains of Mycobacterium tuberculosis.
abstract: 2-[4-(4-Methoxyphenylcarbonyloxy)benzylidene]-6-dime-thylaminomethyl cyclohexanone hydrochloride 1 has a MIC value of 0.78 microg/mL towards Mycobacterium tuberculosis H37Rv and displays similar or identical MIC figures towards various drug-resistant strains of this microorganism. The enone 1 along with a partial structure 2-dimethylaminomethylcyclohexanone hydrochloride 3 affected respiration in isolated rat liver mitochondria differently which may contribute to the variation in toxicity to both normal cells and M. tuberculosis.
authors.affiliation: Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.forename: U
authors.initials: U
authors.lastname: Das
authors.forename: B
authors.initials: B
authors.lastname: Bandy
authors.forename: D K J
authors.initials: DK
authors.lastname: Gorecki
authors.forename: J R
authors.initials: JR
authors.lastname: Dimmock
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003510:Cyclohexanes / Q000494:pharmacology; D004351:Drug Resistance; D066298:In Vitro Techniques; D008352:Mannich Bases / Q000494:pharmacology*; D008744:Methylamines / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D014709:Vero Cells
chemical_list: C554749:2-(4-(4-methoxyphenylcarbonyloxy)benzylidene)-6-dimethylaminomethyl cyclohexanone hydrochloride; D000995:Antitubercular Agents; D003510:Cyclohexanes; D008352:Mannich Bases; D008744:Methylamines