title: The meaning of interaction.
abstract: Although recent studies have attempted to dispel the confusion that exists in regard to the definition, analysis and interpretation of interaction in genetics, there still remain aspects that are poorly understood by non-statisticians. After a brief discussion of the definition of gene-gene interaction, the main part of this study addresses the fundamental meaning of statistical interaction and its relationship to measurement scale, disproportionate sample sizes in the cells of a two-way table and gametic phase disequilibrium.
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106-7281, USA.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.forename: Robert C
authors.initials: RC
authors.lastname: Elston
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
mesh_terms: D003627:Data Interpretation, Statistical; D004843:Epistasis, Genetic; D055614:Genetic Phenomena; D005854:Germ Cells; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D015233:Models, Statistical; D009626:Terminology as Topic