title: Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients.
abstract: OBJECTIVE
  To investigated gene mutations and polymorphisms of TLR9 in Japanese ulcerative colitis (UC) patients.
  
  
  METHODS
  Three single nucleotide polymorphisms (SNPs) in TLR9 were identified in healthy controls, and were assessed in 48 UC patients and 47 healthy controls. Control subjects were matched for age, sex and date of blood sampling from among a subgroup of participants.
  
  
  RESULTS
  TLR9 -1486CC, 1174GG and 2848AA increase the risk of UC [odds ratio (OR) 2.64, 95% confidence interval (95% CI): 1.73-6.53, P = 0.042], and TLR9 -1486TT, 1174AA and 2848GG decrease the risk of UC (OR 0.30, 95% CI: 0.10-0.94, P = 0.039), although there were no correlations between SNPs and disease phenotype or TLR9 mRNA expression.
  
  
  CONCLUSIONS
  TLR9 polymorphisms are associated with increased susceptibility to UC.
authors.affiliation: Department of Gastroenterology and Rheumatology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Fuse
authors.forename: Kyoko
authors.initials: K
authors.lastname: Katakura
authors.forename: Natsumi
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D051217:Toll-Like Receptor 9 / Q000235:genetics*
chemical_list: D051217:Toll-Like Receptor 9