title: [Research advances on hydrogen therapy in nervous system diseases].
abstract: Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Hong
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Zhang
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D006859:Hydrogen / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism; D009420:Nervous System / Q000187:drug effects / Q000378:metabolism*; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D030421:Peroxynitrous Acid / Q000378:metabolism
chemical_list: D000975:Antioxidants; D030421:Peroxynitrous Acid; D017665:Hydroxyl Radical; D006859:Hydrogen