title: Peptide deformylase inhibitors with non-peptide scaffold: synthesis and structure-activity relationships.
abstract: Peptide deformylase (PDF), which removes the formyl group at the N-terminal methionine residue of nascent protein, has been recognized as a potent target for antibacterial therapy. We report herein the synthesis and structure-activity relationship studies of non-peptide PDF inhibitors.
authors.affiliation: Promeditech Ltd, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Lee
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Choi
authors.forename: Sang Jae
authors.initials: SJ
authors.lastname: Lee
authors.forename: Jong Sun
authors.initials: JS
authors.lastname: Lee
authors.forename: Ji Yun
authors.initials: JY
authors.lastname: Park
authors.forename: B Moon
authors.initials: BM
authors.lastname: Kim
authors.forename: Bong Jin
authors.initials: BJ
authors.lastname: Lee
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D020134:Catalytic Domain; D003198:Computer Simulation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D000581:Amidohydrolases; C084507:peptide deformylase