title: Granzyme B as a novel factor involved in cardiovascular diseases.
abstract: Apoptosis plays an important role in cardiovascular diseases such as atherosclerosis, ischemic heart disease, and congestive heart failure. Previous studies have demonstrated that oxidative stress, physiological stress, and inflammatory cytokines such as tumor necrosis factor and Fas ligand are involved in apoptosis of cardiovascular system. We demonstrate that another apoptosis-related pathway, i.e. granzyme B/perforin system is involved in cardiovascular diseases. Expression of granzyme B, a member of serine protease family is increased in acute coronary syndrome, coronary artery disease with end-stage renal disease, and subacute stage of acute myocardial infarction. Although granzyme B is extensively researched in immunological disorders, the role of granzyme B/perforin system was not clear in the cardiovascular field. In addition, little is known regarding the inhibition of granzyme B system in the clinical situation. In this review we demonstrate recent findings of granzyme B in cardiovascular diseases and possible therapeutic applications of inhibiting the granzyme B/perforin system.
authors.affiliation: Department of Cardiology, Catholic Health System, Buffalo, NY, USA.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Saito
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kondo
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Hojo
mesh_terms: D017209:Apoptosis / Q000502:physiology; D050197:Atherosclerosis / Q000209:etiology / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000209:etiology*; D053804:Granzymes / Q000037:antagonists & inhibitors* / Q000502:physiology*; D006801:Humans; D058990:Molecular Targeted Therapy; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology; D054353:Perforin / Q000502:physiology; D058226:Plaque, Atherosclerotic / Q000517:prevention & control; D015843:Serpins / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C102316:SERPINB9 protein, human; D015843:Serpins; D054353:Perforin; D053804:Granzymes