title: [Active compounds from rhizomes of Musa basjoo].
abstract: OBJECTIVE
  To study the active compounds from the rhizomes of Musa basjoo.
  
  
  METHODS
  Antioxidant and alpha-glucosidase inhibitory activity of different extracts were tested. Using bioassay-guided fractionation, the chemical constituents in EtOAC extracts were isolated by column chromatography and identified by MS and NMR spectroscopy.
  
  
  RESULTS
  Five compounds were isolated and identified as 2',3, 4'-trihydroxyflavone (1), 3,3'-bis-hydroxyanigorufone (2), irenolone (3), 4-dihydroxy-9-(4'-hydroxyphenyl)-phenalenone (4) and 3,4-dihydroxybenzaldehyde (5). Compound 1(IC50 8.61 mg x L(-1)), 3 (IC50 19.55 mg x L(-1)) and 5 (IC50 1.1 mg x L(-1)) had antioxidant activity. Compound 2 (IC50 24.15 mg x L(-1)) and 4(IC50 2.81 mg x L(-1)) had alpha-glucosidase inhibitory activity. Compound 5 showed MIC of 0.078, 0.313, 0.039 microg/disc against SA, MRSA and ESBLs, respectively.
  
  
  CONCLUSIONS
  Compound 1-5 were isolated from this plant for the first time. Compound 5 was isolated from the genus Musa for the first time. All compound except 5 were first reported about activity.
authors.affiliation: Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Wenyi
authors.initials: W
authors.lastname: Kang
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D028521:Musa / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology; D000520:alpha-Glucosidases / Q000032:analysis
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D000520:alpha-Glucosidases