title: Assessment of left ventricular volumes, ejection fraction and mass. Comparison of model-based analysis of ECG-gated (⁹⁹m)Tc-SPECT and ¹⁸F-FDG-PET.
abstract: OBJECTIVE
  We compared and delineated possible differences of model-based analysis of ECG-gated SPECT using (⁹⁹m)Tc-sestamibi (Tc-SPECT) with ECG-gated ¹⁸F-fluorodeoxyglucose-PET (FDG-PET) for determination of end-diastolic (EDV) and end-systolic (ESV) cardiac volumes, left ventricular ejection fraction (LVEF), and myocardial mass (LVMM).
  
  
  METHODS
  24 patients (21 men; age: 54±12years) with coronary artery disease underwent Tc-SPECT and FDG-PET imaging for evaluation of myocardial perfusion and viability. By using model-based analysis EDV, ESV, LVEF and LVMM were calculated from short axis images of both Tc-SPECT and FDG-PET.
  
  
  RESULTS
  Left ventricular volumes by Tc-SPECT and FDG-PET were 176±60 ml and 181±59 ml for EDV, and 97±44 ml and 103±45 ml for ESV respectively, LVEF was 47±8% by Tc-SPECT and 45±9% by FDG-PET. The LVMM was 214±40 g (Tc-SPECT) and 202±43 g (FDG-PET) (all p = NS, paired t-test). A significant correlation was observed between Tc-SPECT and FDG-PET imaging for calculation of EDV (r = 0.93), ESV (r = 0.93), LVEF (r = 0.83) and LVMM (r = 0.72).
  
  
  CONCLUSIONS
  ECG-gated Tc-SPECT and FDG-PET using two tracers with different characteristics (perfusion versus metabolism) showed close agreement concerning measurements of left ventricular volumes, contractile function and myocardial mass by using a model-based analysis.
authors.affiliation: Aliasghar Khorsand, PhD., Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. aliasghar.khorsand@meduniwien.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Khorsand
authors.forename: M
authors.initials: M
authors.lastname: Gyöngyösi
authors.forename: H
authors.initials: H
authors.lastname: Sochor
authors.forename: G
authors.initials: G
authors.lastname: Maurer
authors.forename: G
authors.initials: G
authors.lastname: Karanikas
authors.forename: R
authors.initials: R
authors.lastname: Dudczak
authors.forename: E
authors.initials: E
authors.lastname: Schuster
authors.forename: G
authors.initials: G
authors.lastname: Porenta
authors.forename: S
authors.initials: S
authors.lastname: Graf
mesh_terms: D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D013667:Technetium / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D013667:Technetium