title: In vivo biocompatibility study of electrospun chitosan microfiber for tissue engineering.
abstract: In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats.
authors.affiliation: Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Korea; E-Mails: ymkang@ajou.ac.kr (Y.M.K.); leeanm87@ajou.ac.kr (B.N.L.); redboykh@ajou.ac.kr (G.H.K.); knkang@ajou.ac.kr (K.N.K.); dayeon@ajou.ac.kr (D.Y.K.); jhkim@ajou.ac.kr (J.H.K.).
authors.forename: Yun Mi
authors.initials: YM
authors.lastname: Kang
authors.forename: Bit Na
authors.initials: BN
authors.lastname: Lee
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Ko
authors.forename: Gyeong Hae
authors.initials: GH
authors.lastname: Kim
authors.forename: Kkot Nim
authors.initials: KN
authors.lastname: Kang
authors.forename: Da Yeon
authors.initials: DY
authors.lastname: Kim
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Park
authors.forename: Heung Jae
authors.initials: HJ
authors.lastname: Chun
authors.forename: Chun Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Moon Suk
authors.initials: MS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D033581:Stem Cell Transplantation; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D048271:Chitosan