title: Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q10 in elderly men and women.
abstract: Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. We have investigated whether the quality of dietary fat alters postprandial cellular oxidative stress and whether the supplementation with coenzyme Q(10) (CoQ) lowers postprandial oxidative stress in an elderly population. In this randomized crossover study, 20 participants were assigned to receive three isocaloric diets for periods of 4 week each: (1) Mediterranean diet supplemented with CoQ (Med+CoQ diet), (2) Mediterranean diet (Med diet), and (3) saturated fatty acid-rich diet (SFA diet). After a 12-h fast, the volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. CoQ, lipid peroxides (LPO), oxidized low-density lipoprotein (oxLDL), protein carbonyl (PC), total nitrite, nitrotyrosine plasma levels, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and ischemic reactive hyperaemia (IRH) were determined. Med diet produced a lower postprandial GPx activity and a lower decrease in total nitrite level compared to the SFA diet. Med and Med+CoQ diets induced a higher postprandial increase in IRH and a lower postprandial LPO, oxLDL, and nitrotyrosine plasma levels than the SFA diet. Moreover, the Med+CoQ diet produced a lower postprandial decrease in total nitrite and a greater decrease in PC levels compared to the other two diets and lower SOD, CAT, and GPx activities than the SFA diet.In conclusion, Med diet reduces postprandial oxidative stress by reducing processes of cellular oxidation and increases the action of the antioxidant system in elderly persons and the administration of CoQ further improves this redox balance.
authors.affiliation: Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba and CIBER Fisiopatologia Obesidad y Nutricion, Instituto de Salud Carlos III, Spain.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Yubero-Serrano
authors.forename: Nieves
authors.initials: N
authors.lastname: Delgado-Casado
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado-Lista
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Martinez
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Tasset-Cuevas
authors.forename: Monica
authors.initials: M
authors.lastname: Santos-Gonzalez
authors.forename: Javier
authors.initials: J
authors.lastname: Caballero
authors.forename: Antonio
authors.initials: A
authors.lastname: Garcia-Rios
authors.forename: Carmen
authors.initials: C
authors.lastname: Marin
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Gutierrez-Mariscal
authors.forename: Francisco
authors.initials: F
authors.lastname: Fuentes
authors.forename: Jose M
authors.initials: JM
authors.lastname: Villalba
authors.forename: Isaac
authors.initials: I
authors.lastname: Tunez
authors.forename: Francisco
authors.initials: F
authors.lastname: Perez-Jimenez
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
mesh_terms: D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D038441:Diet, Mediterranean; D004041:Dietary Fats / Q000008:administration & dosage; D019587:Dietary Supplements; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D017078:Laser-Doppler Flowmetry; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D019518:Postprandial Period; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D001053:Apolipoproteins; D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D008055:Lipids; D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10