title: Regulation of Candida glabrata oxidative stress resistance is adapted to host environment.
abstract: The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species. We find that induction of conserved genes encoding antioxidant functions is dependent on the transcription factors CgYap1 and CgSkn7 which cooperate for promoter recognition. Superoxide stress resistance of C. glabrata is provided by superoxide dismutase CgSod1, which is not dependent on CgYap1/Skn7. Only double mutants lacking both CgSod1 and CgYap1 were efficiently killed by primary mouse macrophages. Our results suggest that in C. glabrata the regulation of key genes providing stress protection is adopted to meet a host-pathogen situation.
authors.affiliation: Max F. Perutz Laboratories, University of Vienna, Department of Biochemistry, Vienna, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Roetzer
authors.forename: Eva
authors.initials: E
authors.lastname: Klopf
authors.forename: Nina
authors.initials: N
authors.lastname: Gratz
authors.forename: Marina
authors.initials: M
authors.lastname: Marcet-Houben
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Hiller
authors.forename: Steffen
authors.initials: S
authors.lastname: Rupp
authors.forename: Toni
authors.initials: T
authors.lastname: Gabaldón
authors.forename: Pavel
authors.initials: P
authors.lastname: Kovarik
authors.forename: Christoph
authors.initials: C
authors.lastname: Schüller
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D041221:Candida glabrata / Q000378:metabolism*; D005656:Fungal Proteins; D015966:Gene Expression Regulation, Fungal; D008264:Macrophages; D051379:Mice; D018384:Oxidative Stress; D013482:Superoxide Dismutase; D014157:Transcription Factors
chemical_list: D005656:Fungal Proteins; D014157:Transcription Factors; D013482:Superoxide Dismutase