title: TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease.
abstract: Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension, Leonard Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Shafic
authors.initials: S
authors.lastname: El Hindi
authors.forename: Jochen
authors.initials: J
authors.lastname: Reiser
mesh_terms: D000818:Animals; D020022:Genetic Predisposition to Disease; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005921:Glomerulonephritis / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000378:metabolism; D009154:Mutation; D010641:Phenotype; D050199:Podocytes / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D050052:TRPC Cation Channels / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000074287:TRPC6 Cation Channel
chemical_list: D050052:TRPC Cation Channels; D000074287:TRPC6 Cation Channel; C117032:TRPC6 protein, human