title: Proteostenosis and plasma cell pathophysiology.
abstract: Plasma cells differentiate from B lymphocytes to sustain antibody production. As professional secretors, they allow dissecting proteostasis in the exocytic compartment, the stresses that protein production entails and their possible roles in signaling. Most plasma cells are short-lived to limit antibody responses. After a few days of intense immunoglobulin production, they undergo apoptosis, offering a unique model of cellular senescence. Recent observations reveal that proteotoxic stresses physiologically contribute to regulate their biogenesis, function and lifespan, explaining partly the sensitivity of multiple myeloma cells to proteasome inhibitors. This essay summarizes these plasma cell lessons, and their general implications for the regulation of proteostasis, cell senescence and cancer therapeutics.
authors.affiliation: Division of Genetics and Cell Biology, San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, Milano, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Cenci
authors.forename: Eelco
authors.initials: E
authors.lastname: van Anken
authors.forename: Roberto
authors.initials: R
authors.lastname: Sitia
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010950:Plasma Cells / Q000166:cytology / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D013312:Stress, Physiological
chemical_list: D011506:Proteins