title: Could genetic determinants of inner ear anomalies be a factor for the development of idiopathic scoliosis?
abstract: Adolescent idiopathic scoliosis (AIS) is a condition characterized by a three-dimensional structural deformity of the spine. It is the most common type of spine deformity occurring in children aged 10 to maturity. Although the etiology of AIS still remains unknown, the role of genetic factors in the development of idiopathic scoliosis is widely accepted. However, to date no causative genes of AIS have been identified. Recently, the semicircular canals, which are part of the inner ear, were found to be morphologically abnormal in idiopathic scoliosis patients. Here we hypothesized that genetic predisposition to inner ear anomalies in AIS patients may be a strong factor in the generation of idiopathic scoliosis. The proposed idea is that gene defects could impair the development of the semicircular canals. A malformation of semicircular canals might affect the transmission of sensory signal about rotational movement of the body to the central nervous system; leading to an alteration in the neuronal circuit of balance. This will in turn affect body posture and results in the initiation of the curvature of the spine. This hypothesis may provide new insights in the understanding of the pathophysiologic mechanisms of idiopathic scoliosis. It can also offer hopes for potential early prediction of scoliosis.
authors.affiliation: CHU Sainte-Justine Research Center, 3175, Chemin de la Côte Sainte-Catherine Montréal (QC), Canada.
authors.forename: Shunmoogum A
authors.initials: SA
authors.lastname: Patten
authors.forename: Florina
authors.initials: F
authors.lastname: Moldovan
mesh_terms: D000293:Adolescent; D002490:Central Nervous System / Q000503:physiopathology; D002648:Child; D007758:Ear, Inner / Q000002:abnormalities*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007738:Kyphosis / Q000150:complications / Q000503:physiopathology; D008954:Models, Biological; D010808:Physical Examination / Q000009:adverse effects; D011187:Posture; D012600:Scoliosis / Q000209:etiology* / Q000235:genetics* / Q000503:physiopathology; D012665:Semicircular Canals / Q000503:physiopathology; D013131:Spine / Q000254:growth & development* / Q000503:physiopathology