title: Expression of KIR2DL3 and KIR2DS2 natural killer receptors in exercise.
abstract: The mechanisms of early activation of natural killers were studied in volunteers of different athletic qualification. The initial levels of expression of KIR2DL2, PRF1, and GZMB genes regulating the functions of natural killer differ in athletes and untrained subjects. Moderate exercise stimulates transcription activities of these genes. In athletes, the expression increases more intensely than in controls. Stimulation of inhibitory (KIR2DL3) and activation (KIR2DS2) receptors was revealed. This indicated nonspecific stimulation of natural killers, probably mediated by an increase in serum concentration of heat shock protein with a molecular weight of 70 kDa.
authors.affiliation: Institute of Physical Culture and Sports, Moscow, Russia. varja.shlepzova@gmail.com
authors.forename: V A
authors.initials: VA
authors.lastname: Shleptsova
authors.forename: E S
authors.initials: ES
authors.lastname: Grebenyuk
authors.forename: S A
authors.initials: SA
authors.lastname: Khaustova
authors.forename: N P
authors.initials: NP
authors.lastname: Obraztsova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Shkurnikov
authors.forename: D A
authors.initials: DA
authors.lastname: Sakharov
authors.forename: E A
authors.initials: EA
authors.lastname: Tonevitsky
mesh_terms: D015444:Exercise; D006801:Humans; D054340:Receptors, KIR / Q000235:genetics*; D054344:Receptors, KIR2DL3 / Q000235:genetics*; D055607:Receptors, Natural Killer Cell / Q000378:metabolism*
chemical_list: C515078:KIR2DL3 protein, human; C433932:KIR2DS2 protein, human; D054340:Receptors, KIR; D054344:Receptors, KIR2DL3; D055607:Receptors, Natural Killer Cell