title: [Anti-PF4 antibodies and thrombophlebitis in a child with cerebral venous thrombosis].
abstract: We report the case of a 13-year-old girl, with a cerebral venous thrombosis treated initially by heparin. In front of this early thrombocytopenia, in spite of the absence of preliminary treatment by heparin, the "heparin-dependent" anti-PF4 antibodies ELISA assay was realized and turned out to be strongly positive. In spite of the negativity of the specific functional tests, the heparinotherapy was substituted by a treatment by danaparoïd of sodium, allowing a clinico-biological improvement. Because of the low score of HIT imputability, we realized a specific antibodies anti-PF4 alone assay which was strongly positive. This specific positivity probably explains the positivity of the antibodies anti PF4 "heparin-dependent" assay. The originality of this case lies in the young age of the patient and in the probably pathogenic character of these unusual antibodies, in addition markers of an auto-immune disease.
authors.affiliation: Laboratoire d'hématologie, Hôpital de Hautepierre, Strasbourg. dominique.desprez@chru-strasbourg.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Desprez
authors.forename: Philippe
authors.initials: P
authors.lastname: Desprez
authors.forename: Brigitte
authors.initials: B
authors.lastname: Tardy
authors.forename: Jean
authors.initials: J
authors.lastname: Amiral
authors.forename: Chantal
authors.initials: C
authors.lastname: Droulle
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ducassou
authors.forename: Laurent
authors.initials: L
authors.lastname: Mauvieux
authors.forename: Lélia
authors.initials: L
authors.lastname: Grunebaum
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000009:adverse effects; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications*; D010978:Platelet Factor 4 / Q000276:immunology*; D013924:Thrombophlebitis / Q000150:complications*
chemical_list: D000925:Anticoagulants; D001323:Autoantibodies; D010978:Platelet Factor 4; D006493:Heparin