title: Antitussive indole alkaloids from Kopsia hainanensis.
abstract: Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.
authors.affiliation: State Key Laboratory of Drug Research & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
authors.forename: Min-Jia
authors.initials: MJ
authors.lastname: Tan
authors.forename: Chun
authors.initials: C
authors.lastname: Yin
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Tang
authors.forename: Chang-Qiang
authors.initials: CQ
authors.lastname: Ke
authors.forename: Ge
authors.initials: G
authors.lastname: Lin
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D019343:Citric Acid / Q000009:adverse effects; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy*; D006168:Guinea Pigs; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000996:Antitussive Agents; D026121:Indole Alkaloids; D010936:Plant Extracts; C576199:kopsihainin; D019343:Citric Acid; C061491:kopsinine