title: Novel use of the Contura for high dose rate cranial brachytherapy.
abstract: A popular choice for treatment of recurrent gliomas was cranial brachytherapy using the GliaSite Radiation Therapy System. However, this device was taken off the market in late 2008, thus leaving a treatment void. This case study presents our experience treating a cranial lesion for the first time using a Contura multilumen, high-dose-rate (HDR) brachytherapy balloon applicator. The patient was a 47-year-old male who was diagnosed with a recurrent right frontal anaplastic oligodendroglioma. Previous radiosurgery made him a good candidate for brachytherapy. An intracavitary HDR balloon brachytherapy device (Contura) was placed in the resection cavity and treated with a single fraction of 20 Gy. The implant, treatment, and removal of the device were all completed without incident. Dosimetry of the device was excellent because the dose conformed very well to the target. V90, V100, V150, and V200 were 98.9%, 95.7%, 27.2, and 8.8 cc, respectively. This patient was treated successfully using the Contura multilumen balloon. Contura was originally designed for deployment in a postlumpectomy breast for treatment by accelerated partial breast irradiation. Being an intracavitary balloon device, its similarity to the GliaSite system makes it a viable replacement candidate. Multiple lumens in the device also make it possible to shape the dose delivered to the target, something not possible before with the GliaSite applicator.
authors.affiliation: Department of Radiation Oncology, Rebecca and John Moores Comprehensive Cancer Center, University of California at San Diego, La Jolla, CA 92093-0843, USA. dscanderbeg@ucsd.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Scanderbeg
authors.forename: John F
authors.initials: JF
authors.lastname: Alksne
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Lawson
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Murphy
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D009837:Oligodendroglioma / Q000532:radiotherapy* / Q000601:surgery; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D014057:Tomography, X-Ray Computed