title: The relationship between patients' serum glucose levels and metabolically active brown adipose tissue detected by PET/CT.
abstract: OBJECTIVE
  To compare blood glucose levels in patients with or without "detectable" brown adipose tissue (BAT) using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT).
  
  
  METHODS
  Nine hundred eight patients had PET/CT scans and were previously identified as having, or not having, FDG uptake in BAT. The original database was retrospectively reviewed for blood glucose level and body mass index (BMI) at the time of imaging. Blood glucose levels were compared between patients with or without FDG uptake in BAT, adjusting for age, sex, and BMI.
  
  
  RESULTS
  Fifty-six patients (6.2%) had FDG uptake in BAT. In the univariate analysis, patients without FDG uptake in BAT had a higher risk of glucose ≥100 mg/dL (odds ratio 3.4, 95% CI = 1.6-7.3; P = 0.0007). After adjustment for age, sex, BMI, and significant interaction of sex and BMI, patients without BAT tended to have a higher risk of glucose ≥100 mg/dL, although not statistically significant (odds ratio = 1.6, 95% CI = 0.7-3.6; P = 0.268).
  
  
  CONCLUSIONS
  Although causal relationships are not specified, the data suggest that BAT uptake, glucose levels, BMI, sex, and age are inter-related and the possibility that presence of "detectable" BAT is protective against diabetes and obesity. FDG PET/CT may be a vital tool for further investigations of diabetes and obesity.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Heather A
authors.initials: HA
authors.lastname: Jacene
authors.forename: Christian C
authors.initials: CC
authors.lastname: Cohade
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Richard L
authors.initials: RL
authors.lastname: Wahl
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging*; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D015999:Multivariate Analysis; D049268:Positron-Emission Tomography; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D001786:Blood Glucose