title: [Accelerated postoperative radiotherapy in patients with advanced larynx cancer].
abstract: OBJECTIVE
  The aim of study was test efficacy of accelerated postoperative radiotherapy--concomitant boost in patients with advanced larynx cancer.
  
  
  METHODS
  The prospective study included 112 patients with advanced larynx cancer after radical surgical treatment. Patients had postoperative radiation therapy, conventional (C) or accelerated (CB).
  
  
  RESULTS
  The 3-year overall survival in CB was 59%, in C--58% (p = 0.2), 3-year locoregional control in CB--83%, in C--75% (p = 0.01), the 3-year disease free survival was in CB--72%, C--66% (p = 0.1).
  
  
  CONCLUSIONS
  Concomitant boost postoperative radiation therapy did not improve overall survival, loco-regional control, disease free survival. Patients with close surgical margins, longer interval between surgery and radiation, high level of hemoglobin, T4 had benefit from accelerated radiotherapy.
authors.affiliation: Oddzial Kliniczny Radioterapii PAM. jkubrak@wp.pl
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Kubrak
authors.forename: Maria
authors.initials: M
authors.lastname: Chosia
authors.forename: Piotr
authors.initials: P
authors.lastname: Maj
authors.forename: Alina
authors.initials: A
authors.lastname: Jarema
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D011044:Poland; D011182:Postoperative Care / Q000379:methods*; D011859:Radiography; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000706:statistics & numerical data; D018570:Risk Assessment; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents