title: Sesquiterpenes from Chloranthus japonicus.
abstract: Eight new sesquiterpene lactones (chlorajapolides A-E, 1-5, chlorajaposide, 6, chlorajaponol, 7, and chloraeudolide, 8) were isolated from an ethyl acetate-soluble partition of the ethanol extract of the whole plants of Chloranthus japonicus. The structures and relative configurations of 1-8 were established on the basis of spectroscopic data analysis. All isolates obtained were evaluated for their cytotoxic activity against a small panel of cancer cell lines.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
authors.forename: Bing-You
authors.initials: BY
authors.lastname: Yang
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Xia
authors.forename: Jun-Song
authors.initials: JS
authors.lastname: Wang
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue