title: Synthesis and fluorescence investigation of differently substituted benzo[b][1,8]naphthyridines: interaction with different solvents and bovine serum albumin (BSA).
abstract: A series of benzo[b][1, 8]naphthyridines has been synthesized by Friedländer condensation of 2-aminoquinoline-3-carbaldehyde 1 (o-aminoaldehyde) with active methylenes in basic medium. The fluorescence spectroscopic properties of some representative compounds has been studied in different organic solvents; moreover interaction with bovine serum albumin (BSA) in phosphate buffer was examined by UV-vis and fluorescence spectroscopy. The effect of electron donor-acceptor substituents on fluorescence properties of benzo[b][1, 8]naphthyridines 13(a-n) has been investigated along with their fluorescent quantum yields.
authors.affiliation: Organic Chemistry Research Center, Department of Chemistry, K. T. H. M. College, Gangapur Road, Nashik 422002 MS, India.
authors.forename: Deepak P
authors.initials: DP
authors.lastname: Shelar
authors.forename: Sandeep R
authors.initials: SR
authors.lastname: Patil
authors.forename: Ramhari V
authors.initials: RV
authors.lastname: Rote
authors.forename: Raghunath B
authors.initials: RB
authors.lastname: Toche
authors.forename: Madhukar N
authors.initials: MN
authors.lastname: Jachak
mesh_terms: D000818:Animals; D005453:Fluorescence; D009287:Naphthyridines / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009287:Naphthyridines; D012997:Solvents; C036477:benzo(b)1,5-naphthyridine; D012710:Serum Albumin, Bovine