title: Cyclin-dependent kinase inhibitor p27 as a prognostic biomarker and potential cancer therapeutic target.
abstract: The prognosis and clinical management of patients with cancer is commonly determined by traditional clinical and pathological factors. Nevertheless, patients may present with significantly different clinical outcomes despite similar clinicopathological features. This has prompted intense research to find biological markers that may closely reflect tumor biology and thereby clinical outcome. This article presents the current knowledge on the prognostic significance of p27 expression in cancer and its potential role as a target for future therapy.
authors.affiliation: Department of Surgery & Breast Health Institute, Rambam Health Care Campus & the Technion-Israel Institute of Technology, Haifa, Israel. d_hershko@ramabam.health.gov.il
authors.forename: Dan D
authors.initials: DD
authors.lastname: Hershko
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002453:Cell Cycle / Q000502:physiology; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000096:biosynthesis*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D050760:Cyclin-Dependent Kinase Inhibitor p27