title: "Spice" girls: synthetic cannabinoid intoxication.
abstract: BACKGROUND
  "Spice" refers to various synthetic cannabinoid-containing products that seem to have rapidly become popular recreational drugs of abuse. Very little medical literature currently exists detailing the adverse effects and emergency department (ED) presentations associated with "spice" use.
  
  
  OBJECTIVE
  To describe the presentation of 2 patients who recreationally used a "spice" product and to briefly summarize what is known about "spice" and synthetic cannabinoids.
  
  
  METHODS
  Two patients presented to the ED with, predominantly, anxiety after recreationally using a "spice" product that we subsequently confirmed to contain the synthetic cannabinoids, JWH-018 and JWH-073.
  
  
  CONCLUSIONS
  We suspect that use of "spice" products may increase. Although anxiety was a prominent presentation in both of the patients described here, undoubtedly, future studies will describe the manifestations of intoxication and toxicity with the various synthetic cannabinoids.
authors.affiliation: Division of Medical Toxicology, University of California, San Diego Medical Center, San Diego, California 92103-8925, USA.
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Schneir
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cullen
authors.forename: Binh T
authors.initials: BT
authors.lastname: Ly
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D001007:Anxiety / Q000139:chemically induced*; D002186:Cannabinoids / Q000009:adverse effects*; D004636:Emergency Service, Hospital; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects*; D018570:Risk Assessment; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000931:Antidotes; D002186:Cannabinoids; D013287:Illicit Drugs