title: [Three cases of radiotherapy combined with S-1 and mitomycin C for anal canal squamous cell carcinomas].
abstract: We report three cases of anal canal squamous cell carcinoma treated with radiotherapy combined with S-1 and mitomycin C(MMC). During radiotherapy, MMC was administered as intravenous bolus injection at a dose of 10mg/m2 on day 1 and 29. S-1 was administered orally at a dose of 80mg/m2 on days 1-14 and 29-43. Total radiation doses ranged 55. 8-60 Gy to pelvic lesions. The rates of grade 3 toxicity were: neutropenia, 100%; leucopenia, 100%; anemia, 33. 3%; anorexia, 66. 7%. These adverse events were tolerated. All of the three cases showed complete response without recurrences. These results suggested that this treatment schedule was safe and effective for anal canal carcinomas.
authors.affiliation: Dept. of Gastrointestinal Surgery, Kanagawa Cancer Center.
authors.forename: Manabu
authors.initials: M
authors.lastname: Shiozawa
authors.forename: Ken
authors.initials: K
authors.lastname: Nishimura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nonaka
authors.forename: Takako
authors.initials: T
authors.lastname: Yoshii
authors.forename: Norisuke
authors.initials: N
authors.lastname: Nakayama
authors.forename: Osamu
authors.initials: O
authors.lastname: Motohashi
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takagi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Makoto
authors.initials: M
authors.lastname: Akaike
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001003:Anal Canal; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D011879:Radiotherapy Dosage
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil