title: Atrophic rhinosinusitis: progress toward explanation of an unsolved medical mystery.
abstract: OBJECTIVE
  Atrophic rhinosinusitis is a chronic condition associated with considerable morbidity and decreased quality of life. This review describes progress in the characterization of primary and secondary atrophic rhinosinusitis and the development of diagnostic criteria for both syndromes.
  
  
  RESULTS
  Primary atrophic rhinitis usually develops as a consequence of an acute febrile illness in members of lower socioeconomic groups in developing areas of the world. The clinical setting and presence of culturable Klebsialla ozenae in the purulent, foul-smelling, nasal discharge of these patients forms the basis for diagnosis. An animal model for the disease exists in swine in which case an effective vaccine has been developed. Secondary atrophic rhinosinusitis is a condition that follows destruction of the nasal mucosa by any of a number of inflammatory processes including inflammatory diseases nasal/sinus surgery, and antiangiogenic therapy. Diagnostic criteria include patient reported recurrent epistaxis or episodic anosmia; or physician documented nasal purulence, nasal crusting, chronic inflammatory disease involving the upper airway (e.g. sarcoidosis, Wegener's granulomatosis, etc.) or two or more sinus surgeries. Patients with two more of these have secondary atrophic rhinitis with a sensitivity of 0.95 and a specificity of 0.77.
  
  
  CONCLUSIONS
  Atrophic rhinosinusitis results from destruction of the normal respiratory epithelium and transition to a nonciliated squamous epithelium, loss of mucociliary clearance, accumulation of stagnant mucous. That milieu facilitates acute and chronic infection (wet phase), and eventual sclerosis with epistaxis and chronic bloody crusts (dry phase).
authors.affiliation: Department of Medicine, Division of Clinical Allergy and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, USA. rdeshazo@umc.edu
authors.forename: Richard D
authors.initials: RD
authors.lastname: deShazo
authors.forename: Scott P
authors.initials: SP
authors.lastname: Stringer
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002908:Chronic Disease; D004195:Disease Models, Animal; D006801:Humans; D006920:Hygiene; D012222:Rhinitis, Atrophic / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012852:Sinusitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013552:Swine; D013553:Swine Diseases / Q000175:diagnosis / Q000209:etiology; D007507:Therapeutic Irrigation
chemical_list: D000900:Anti-Bacterial Agents