title: [Expression and clinical implication of Matrix Metalloproteinase-1 and Vascular Endothelial Growth Factor in retinoblastoma].
abstract: OBJECTIVE
  To investigate the expression of matrix metalloproteinase-1 (MMP-1) and vascular endothelial growth factor(VEGF) in the retinoblastoma and to identify their relationships with clinicopathology characteristics in order to determine their effects on the angiogenesis.
  
  
  METHODS
  Thirty-one patients with histologically proved retinoblastoma were enrolled to examine the expression of MMP-1and VEGF by Immunohistochemistry technique. The relationship between expression and the staging of tumor was analyzed.
  
  
  RESULTS
  The MMP-1 and VEGF were highly expressed in retinoblastoma, and MMP-1, VEGF mainly expressed in tumor cells. MMP-1and VEGF was positively correlated with tumor stage(p<0.05). The expression MMP-1 was positively correlated with VEGF level (R=0.787, p<0.00).
  
  
  CONCLUSIONS
  The MMP-1 and VEGF are highly expressed in retinoblastoma cells. The expression is related to clinical invasion and metastasis. MMP-1 expression is positively related to VEGF level.MMP-1and VEGF may play an important role in angiogenesis and tumor progression in retinoblastoma.
authors.affiliation: Department of Ophothalmology, the First Affiliated Hospital of Gannan Medical University, Ganzhou.
authors.forename: Siqi
authors.initials: S
authors.lastname: Yuan
authors.forename: Hua
authors.initials: H
authors.lastname: Song
mesh_terms: D006801:Humans; D020781:Matrix Metalloproteinase 1; D009389:Neovascularization, Pathologic / Q000378:metabolism; D012175:Retinoblastoma; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D020781:Matrix Metalloproteinase 1