title: [Standard doses of tadalafil for different ED patients].
abstract: OBJECTIVE
  To observe the effects of different doses of tadalafil on ED, and to search for appropriate doses for the treatment of different ED patients.
  
  
  METHODS
  Based on the baseline peak systolic velocity (PSV) of cavernosal arteries, 136 ED patients were divided into Groups A (PSV > 15 cm/s), B (PSV > 15 cm/s), C (PSV < 15 cm/s) and D (PSV <15 cm/s) to receive oral tadalafil at 10 mg (Groups A and C) and 5 mg (Groups B and D) on alternate days for 4 weeks. All of them were scored on IIEF-5 and detected for PSVs of the bilateral cavernosal arteries by color Doppler ultrasonography and intracavernous injection of prostaglandin E1 before and after the medication.
  
  
  RESULTS
  After 4 weeks of tadalafil treatment, IIEF-5 scores and PSVs were remarkably improved in all the four groups as compared with the baseline (P < 0.01), significantly higher in Group C than in D (P < 0.01), but with no significant differences between A and B.
  
  
  CONCLUSIONS
  Oral tadalafil can improve PSV and hence penile erection in ED patients either at a low or a high dose. To reduce side effects and drug cost, the patients with PSV >15 cm/s can be medicated at 5 mg, while those with PSV < 15 cm/s at 10 mg or more on alternate days.
authors.affiliation: Department of Urology, Drum Tower Hospital Affiliated to Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhi-peng
authors.initials: ZP
authors.lastname: Xu
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Zhu
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.forename: Yu-tian
authors.initials: YT
authors.lastname: Dai
mesh_terms: D000328:Adult; D000368:Aged; D002243:Carbolines / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010410:Penile Erection; D000068581:Tadalafil; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D002243:Carbolines; D014665:Vasodilator Agents; D000068581:Tadalafil