title: Effect of anoceptin on detoxifying function of the liver.
abstract: The absence of negative effects of anoceptin on the liver tissue and detoxifying function was proven experimentally in vitro and in vivo. It was proven for the first time that comenic acid (anoceptin active substance) in concentrations of 10(-4)-10(-12) does not modulate the growth of liver explants from 10-12-day chicken embryos. The effect of anoceptin on the detoxifying function of the liver was studied on Wistar rats under conditions of hexenal-induced sleep. The drug was injected into the caudal vein for 90 days in a daily dose of 5, 100, or 300 mg/kg. The duration of hexenal-induced sleep was evaluated before and on days 30 and 90 of the study. Anoceptin did not modify the duration of hexenal-induced sleep and the status and detoxifying function of the liver.
authors.affiliation: Laboratory of Stimulated Membrane Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kipenko
authors.forename: V A
authors.initials: VA
authors.lastname: Penniyaynen
authors.forename: E V
authors.initials: EV
authors.lastname: Lopatina
authors.forename: V A
authors.initials: VA
authors.lastname: Tsyrlin
authors.forename: G I
authors.initials: GI
authors.lastname: Lobov
authors.forename: B V
authors.initials: BV
authors.lastname: Krylov
mesh_terms: D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology*; D002642:Chick Embryo; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D011753:Pyrones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002264:Carboxylic Acids; D011753:Pyrones; C488376:comenic acid