title: Leukotrienes antagonize the antiproliferative effect of Larrea divaricata Cav. on a lymphoma cell line interfering with cAMP intracellular level and PKC activity.
abstract: Larrea divaricata exerts a dual effect on the proliferation of BW5147 cells. The aim of this work was to analyze the effect of leukotrienes on the antiproliferative action of the extract in relation to cyclic adenosine monophosphate production and protein kinase C activation. The extracts induced cyclic adenosine monophosphate and inhibited protein kinase C but induced leukotriene B4 production, which exerted contrary effects. These results suggest the finding of an extract free of compounds, which can increase leukotriene B4 level, in order to obtain a more active extract to be used in the treatment of lymphomas, positively modulated by leukotrienes.
authors.affiliation: IQUIMEFA-CONICET-UBA, Buenos Aires, Argentina,1 CEFYBO-CONICET-UBA, Buenos Aires, Argentina.
authors.forename: Roberto
authors.initials: R
authors.lastname: Davicino
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Genaro
authors.forename: Graciela
authors.initials: G
authors.lastname: Cremaschi
authors.forename: Claudia
authors.initials: C
authors.lastname: Anesini
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006152:Cyclic GMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D032442:Larrea; D007975:Leukotriene B4 / Q000378:metabolism*; D016399:Lymphoma, T-Cell / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D015854:Up-Regulation
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; D007975:Leukotriene B4; D011493:Protein Kinase C; D006152:Cyclic GMP