title: Formation of conjugates from ciprofloxacin and norfloxacin in cultures of Trichoderma viride.
abstract: The formation of conjugates from two antibacterial fluoroquinolone drugs, ciprofloxacin and norfloxacin, was observed in cultures of Trichoderma viride that had been grown in sucrose-peptone broth and extracted 16 d after dosing with the drugs. Both conjugates were purified by high-performance liquid chromatography and found to be optically active. They were identified by mass and proton nuclear magnetic resonance spectra as 4-hydroxy-3-oxo-4-vinylcyclopent-1-enyl ciprofloxacin and 4-hydroxy-3-oxo-4-vinylcyclopent-1-enyl norfloxacin. The transformation of veterinary fluoroquinolones in the presence of fungi may have ecological significance.
authors.affiliation: National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502.
authors.forename: Igor A
authors.initials: IA
authors.lastname: Parshikov
authors.forename: Joanna D
authors.initials: JD
authors.lastname: Moody
authors.forename: James P
authors.initials: JP
authors.lastname: Freeman
authors.forename: Jackson O
authors.initials: JO
authors.lastname: Lay
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Williams
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Heinze
authors.forename: John B
authors.initials: JB
authors.lastname: Sutherland