title: Interaction of long-chain n-alcohols with fluid DOPC bilayers: a neutron diffraction study.
abstract: Lamellar phases composed of fluid dioleoylphosphatidylcholine (DOPC) bilayers containing alkan-1-ols (CnOH, n = 8, 10, 14, 16, 18 is the number of carbon atoms) at CnOH : DOPC = 0.3 molar ratio and hydrated with heavy water at 20.2 ≥ D2O : DOPC ≥ 14.4 molar ratio were studied by neutron diffraction. The bilayer thickness d(L) and the bilayer surface area A(L) per DOPC at the bilayer-water interface were obtained from the lamellar repeat period d using molecular volumes of DOPC, CnOH and D2O, and the Luzatti's method. Both the d(L) and A(L) increase with the CnOH chain length n at CnOH : DOPC = 0.3 molar ratio: d(L) = (3.888 ± 0.066) + (0.016 ± 0.005)·n (in nm), A(L) = (0.6711 ± 0.0107) + (0.0012 ± 0.0008)·n (in nm²).
authors.affiliation: Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia. vip@nf.jinr.ru
authors.forename: Viktor I
authors.initials: VI
authors.lastname: Petrenko
authors.forename: Maria
authors.initials: M
authors.lastname: Klacsova
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Beskrovnyy
authors.forename: Daniela
authors.initials: D
authors.lastname: Uhrikova
authors.forename: Pavol
authors.initials: P
authors.lastname: Balgavy
mesh_terms: D000438:Alcohols / Q000737:chemistry* / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D008560:Membrane Fluidity; D033363:Neutron Diffraction; D010713:Phosphatidylcholines / Q000737:chemistry* / Q000378:metabolism*; D053838:Scattering, Small Angle
chemical_list: D000438:Alcohols; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; C017251:1,2-oleoylphosphatidylcholine