title: A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2.
abstract: Tyrosine phosphatase Src-homology phosphotyrosyl phosphatase 2 (Shp2) was identified as a potential molecular target for therapeutic treatment of diabetes and obesity. However, there is still no systematic research on the enhancers for the Shp2 enzyme. The present study established a novel powerful model for the high-throughput screening of Shp2 enhancers and successfully identified a new specific Shp2 enhancer, oleanolic acid, from Chinese herbs.
authors.affiliation: Xiamen City Key Laboratory of Metabolism Disease and Metabolic Disease Research Center, Institute for Biomedical Research, Lu Jiaxi Hall, Room 630, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Bu
authors.forename: Tao
authors.initials: T
authors.lastname: Shi
authors.forename: Minghui
authors.initials: M
authors.lastname: Meng
authors.forename: Guiping
authors.initials: G
authors.lastname: Kong
authors.forename: Yingpu
authors.initials: Y
authors.lastname: Tian
authors.forename: Quancheng
authors.initials: Q
authors.lastname: Chen
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Gensheng
authors.initials: G
authors.lastname: Feng
authors.forename: Haifeng
authors.initials: H
authors.lastname: Chen
authors.forename: Haifeng
authors.initials: H
authors.lastname: Cheng
authors.forename: Zhongxian
authors.initials: Z
authors.lastname: Lu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000201:enzymology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D031657:Forsythia / Q000737:chemistry*; D006801:Humans; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D009765:Obesity / Q000188:drug therapy* / Q000201:enzymology; D009828:Oleanolic Acid / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D009828:Oleanolic Acid; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11