title: Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure.
abstract: BACKGROUND
  Elevated cardiac troponin T is a well-documented marker of cardiomyocyte damage and poor prognosis in patients with heart failure. We prospectively evaluated the relationship between this marker and hematopoietic disturbances in heart failure.
  
  
  METHODS
  Data were analyzed from 254 patients in the UNITE-HF Biomarker Registry, a prospective, observational, multicenter study of the clinical and biomarker correlates of anemia in heart failure. Logistic regression modeling assessed relationships between detectable troponin T and indices of hematologic function including anemia and red cell distribution width.
  
  
  RESULTS
  Anemia (hemoglobin≤12 g/dL) was present in 65 of the 254 study patients, and detectable troponin T was found in 39. Anemia was a significant independent predictor of detectable troponin T in models that considered a number of clinical characteristics including renal function, functional class, heart rate, and systolic blood pressure (odds ratio 2.57, 95% CI 1.09-6.09, P=.032). Likewise, detectable troponin T was directly and independently related to red cell distribution width in similar multivariable analyses (odds ratio 1.36 per unit increase, 95% CI 1.08-1.71, P=.008).
  
  
  CONCLUSIONS
  Anemia and increasing red cell distribution width were independently associated with elevated troponin T, a marker of cardiomyocyte injury or death in patients with heart failure.
authors.affiliation: Department of Medicine and Radiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA. kfa@med.unc.edu
authors.forename: Kirkwood F
authors.initials: KF
authors.lastname: Adams
authors.forename: Mandeep R
authors.initials: MR
authors.lastname: Mehra
authors.forename: Ron M
authors.initials: RM
authors.lastname: Oren
authors.forename: Christopher M
authors.initials: CM
authors.lastname: O'Connor
authors.forename: Jun R
authors.initials: JR
authors.lastname: Chiong
authors.forename: Jalal K
authors.initials: JK
authors.lastname: Ghali
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Lenihan
authors.forename: Stephanie H
authors.initials: SH
authors.lastname: Dunlap
authors.forename: J Herbert
authors.initials: JH
authors.lastname: Patterson
authors.forename: Todd A
authors.initials: TA
authors.lastname: Schwartz
authors.forename: G Michael
authors.initials: GM
authors.lastname: Felker
mesh_terms: D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004906:Erythrocyte Count; D004920:Erythropoiesis / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T