title: The Lrp family of transcription regulators in archaea.
abstract: Archaea possess a eukaryotic-type basal transcription apparatus that is regulated by bacteria-like transcription regulators. A universal and abundant family of transcription regulators are the bacterial/archaeal Lrp-like regulators. The Lrp family is one of the best studied regulator families in archaea, illustrated by investigations of proteins from the archaeal model organisms: Sulfolobus, Pyrococcus, Methanocaldococcus, and Halobacterium. These regulators are extremely versatile in their DNA-binding properties, response to effector molecules, and molecular regulatory mechanisms. Besides being involved in the regulation of the amino acid metabolism, they also regulate central metabolic processes. It appears that these regulatory proteins are also involved in large regulatory networks, because of hierarchical regulations and the possible combinatorial use of different Lrp-like proteins. Here, we discuss the recent developments in our understanding of this important class of regulators.
authors.affiliation: Erfelijkheidsleer en Microbiologie, Vrije Universiteit Brussel, Brussel, Belgium. espeeter@vub.ac.be
authors.forename: Eveline
authors.initials: E
authors.lastname: Peeters
authors.forename: Daniel
authors.initials: D
authors.lastname: Charlier
mesh_terms: D001105:Archaea / Q000737:chemistry / Q000378:metabolism*; D019848:Gene Expression Regulation, Archaeal; D051756:Leucine-Responsive Regulatory Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D010802:Phylogeny
chemical_list: D051756:Leucine-Responsive Regulatory Protein