title: Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents.
abstract: A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
authors.affiliation: School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. wjyxyzyj@yahoo.com.cn
authors.forename: Yujin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongwan
authors.initials: H
authors.lastname: Chu
authors.forename: Hongquan
authors.initials: H
authors.lastname: Duan
mesh_terms: D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007333:Insulin Resistance; D009682:Magnetic Resonance Spectroscopy; D008687:Metformin / Q000737:chemistry / Q000494:pharmacology; D008954:Models, Biological; D015394:Molecular Structure
chemical_list: D005419:Flavonoids; D007004:Hypoglycemic Agents; C052083:tiliroside; D008687:Metformin; D005947:Glucose