title: Ketonuria after fasting may be related to the metabolic superiority.
abstract: Obese individuals are less able to oxidize fat than non-obese individuals. Caloric reduction or fasting can detect ketonuria. We investigated the differences of metabolic parameters in the presence of ketonuria after a minimum 8 hr fast in a cross-sectional analysis of 16,523 Koreans (6,512 women and 10,011 men). The relationship between the presence of ketonuria of all subjects and prevalence of obesity, central obesity, metabolic syndrome, and obesity-related metabolic parameters were assessed. The ketonuria group had lower prevalence of obesity, central obesity, and metabolic syndrome than the non-ketonuria group. In addition, all metabolic parameters (including body weight, waist circumference, blood glucose, high-density lipoprotein, triglyceride, blood pressure, and insulin) were favorable in the ketonuria group than in the non-ketonuria group, even after adjustment for age, tobacco use, and alcohol consumption. The odds ratios of having obesity (odds ratio [OR]=1.427 in women, OR=1.582 in men, P<0.05), central obesity (OR=1.675 in women, OR=1.889 in men, P<0.05), and metabolic syndrome (OR=3.505 in women, OR=1.356 in men, P<0.05) were increased in the non-ketonuria group compared to the ketonuria group. The presence of ketonuria after at least an 8 hr fast may be indicative of metabolic superiority.
authors.affiliation: Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Nam-Seok
authors.initials: NS
authors.lastname: Joo
authors.forename: Duck-Joo
authors.initials: DJ
authors.lastname: Lee
authors.forename: Kwang-Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Bom-Taeck
authors.initials: BT
authors.lastname: Kim
authors.forename: Chan-Won
authors.initials: CW
authors.lastname: Kim
authors.forename: Kyu-Nam
authors.initials: KN
authors.lastname: Kim
authors.forename: Sang-Man
authors.initials: SM
authors.lastname: Kim
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001835:Body Weight; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007662:Ketosis / Q000150:complications* / Q000175:diagnosis; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D016017:Odds Ratio; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008075:Lipoproteins, HDL; D014280:Triglycerides