title: Opposite effects of two nonstructural proteins of Theiler’s murine encephalomyelitis virus regulates apoptotic cell death in BHK-21 cells.
abstract: Theiler’s murine encephalomyelitis virus is divided into two subgroups, TO and GDVII, inducing subgroup-specific diseases. In order to investigate the role(s) of nonstructural proteins of TMEV, L and L(∗), leaders of two subgroups, were separately expressed with or without L(∗) in BHK-21 cells. Expression of L increased the number of apoptotic cells. L(∗)/BHK-21 cells constitutively expressing L(∗) showed the decrease in cell death induced by L. These results suggest that L and L(∗) regulate apoptosis during viral infection and contribute to TMEV subgroup-specific biological activities.
authors.affiliation: Department of Microbiology, Kanazawa Medical University School of Medicine, Uchinada, Ishikawa, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Okuwa
authors.forename: Naoko
authors.initials: N
authors.lastname: Taniura
authors.forename: Mineki
authors.initials: M
authors.lastname: Saito
authors.forename: Toshiki
authors.initials: T
authors.lastname: Himeda
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Ohara
mesh_terms: D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D006224:Cricetinae; D017945:Theilovirus / Q000737:chemistry / Q000472:pathogenicity*; D017361:Viral Nonstructural Proteins / Q000502:physiology*
chemical_list: D017361:Viral Nonstructural Proteins