title: Regioselective cobalt-catalyzed alder-ene reaction toward silicon- and boron-functionalized building blocks.
abstract: The cobalt-catalyzed formal Alder-ene reaction of functionalized alkenes and alkynes leads to bifunctionalized 1,4-dienes in high yields and excellent regio- and stereoselectivities. The silicon-functionalized building blocks are easily converted into iodo-functionalized derivatives and in combination with boron-functionalized building blocks polyenes can be generated utilizing a Suzuki cross-coupling. In addition, building blocks incorporating allylic silane functionalities can be used in Sakurai allylation or Prins-type cyclization reactions for the synthesis of heterocyclic products such as tetrahydrofuranes or tetrahydropyranes.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Str., 35043 Marburg, Germany. hilt@chemie.uni-marburg.de
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hilt
authors.forename: Florian
authors.initials: F
authors.lastname: Erver
authors.forename: Klaus
authors.initials: K
authors.lastname: Harms