title: Lipid trafficking sans vesicles: where, why, how?
abstract: Eukaryotic cells possess a remarkable diversity of lipids, which distribute among cellular membranes by well-characterized vesicle trafficking pathways. However, transport of lipids by alternate, or "nonvesicular," routes is also critical for lipid synthesis, metabolism, and proper membrane partitioning. In the past few years, considerable progress has been made in characterizing the mechanisms of nonvesicular lipid transport and how it may go awry in particular diseases, but many fundamental questions remain for this rising field.
authors.affiliation: Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. williamp@intra.niddk.nih.gov
authors.forename: William A
authors.initials: WA
authors.lastname: Prinz
mesh_terms: D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry; D005057:Eukaryotic Cells / Q000737:chemistry*; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D015388:Organelles / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D008055:Lipids