title: The beneficial effects of tadalafil on renal ischemia-reperfusion injury in rats.
abstract: Acute renal failure due to ischemia-reperfusion (I/R) injury is a common complication in cardiovascular surgery. We determined the influence of tadalafil on renal injury in a renal I/R model in rats. For this purpose, 21 male Wistar albino rats were separated into 3 groups: sham, placebo and tadalafil. A right nephrectomy was performed, and the left renal pedicles were occluded for 60 min and reperfused for 60 min in the placebo and tadalafil groups. A single dose of tadalafil (10 mg/kg) through an orogastric tube was administered to the tadalafil group. Tubular atrophy with acute inflammation in renal histology, total oxidant status (TOS) and total antioxidant status (TAS) were determined in tissue homogenates. Compared to the tadalafil group, tubular atrophy and acute inflammation was significant in the placebo group. TAS levels were significantly higher in the tadalafil group compared to the placebo (p = 0.01) and sham groups (p = 0.04). While TOS levels were significantly higher in the placebo group (p = 0.03), tadalafil did not significantly alter the TOS levels. The beneficial effects of tadalafil can be attributed to its protective effects on renal tubular cells and inhibition of leukocyte infiltration in renal tissue. We think that tadalafil treatment has an important role in reducing renal injury resulting from renal I/R.
authors.affiliation: Department of Cardiovascular Surgery, Tayfur Ata Sokmen Medical Faculty, Mustafa Kemal University, Hatay, Turkey. mehmetguzeloglu @ hotmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Guzeloglu
authors.forename: Fatih
authors.initials: F
authors.lastname: Yalcinkaya
authors.forename: Soner
authors.initials: S
authors.lastname: Atmaca
authors.forename: Alper
authors.initials: A
authors.lastname: Bagriyanik
authors.forename: Suleyman
authors.initials: S
authors.lastname: Oktar
authors.forename: Oguz
authors.initials: O
authors.lastname: Yuksel
authors.forename: Iyad
authors.initials: I
authors.lastname: Fansa
authors.forename: Eyup
authors.initials: E
authors.lastname: Hazan
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001284:Atrophy; D002243:Carbolines / Q000494:pharmacology*; D007249:Inflammation; D007668:Kidney / Q000473:pathology*; D007962:Leukocytes / Q000166:cytology; D008297:Male; D016877:Oxidants / Q000737:chemistry / Q000378:metabolism; D010919:Placebos; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury; D000068581:Tadalafil; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D002243:Carbolines; D016877:Oxidants; D010919:Placebos; D014665:Vasodilator Agents; D000068581:Tadalafil