title: 2007 San Diego wildfires and asthmatics.
abstract: BACKGROUND
  This case series reports the changes in the respiratory health of eight asthmatic subjects and the relationship with air quality associated with the October 2007 firestorm in San Diego County of California.
  
  
  METHODS
  Participants were eight subjects with asthma enrolled in Asthma Clinical Research Network (ACRN) (NIH# U10-HL074218) studies at the University of California San Diego (UCSD), School of Medicine, who had study data collected immediately prior, during and 1 month after the 5-day firestorm in San Diego County. Air quality deteriorated to an extreme average of 71.5 mg/m(3) small particulate matter less than 2.5 μm (PM(2.5)) during the firestorm. Respiratory health data included morning and evening peak expiratory flow rates (PEFR), morning and evening Forced Expiratory Volume in one second (FEV(1)), rescue medication usage, and sputum eosinophils. Morning and evening PEFR and FEV(1) rates remained stable. The two subjects tested during the fires had elevated eosinophil counts and rescue medication usage was increased in five of the eight subjects.
  
  
  CONCLUSIONS
  Pulmonary function test values were stable during the wildfires for all eight subjects but there was a statistically significant increase in rescue medication usage during the wildfires that correlated with PM(2.5) values. The two subjects tested during the fires showed increases in sputum eosinophil counts consistent with increased airways inflammation.
  
  
  CONCLUSIONS
  These findings suggest that poor air quality associated with wildfires resulted in an increase in airways inflammation in these asthmatic subjects, but pulmonary function tests remained stable, possibly due to increased rescue medication usage. This is especially pertinent as there is an increase in incidence of wildfires this decade.
authors.affiliation: Department of Medicine, School of Medicine, University of California, San Diego, CA, USA.
authors.forename: Chirag
authors.initials: C
authors.lastname: Vora
authors.forename: Marian J
authors.initials: MJ
authors.lastname: Renvall
authors.forename: Peter
authors.initials: P
authors.lastname: Chao
authors.forename: Paul
authors.initials: P
authors.lastname: Ferguson
authors.forename: Joe W
authors.initials: JW
authors.lastname: Ramsdell
mesh_terms: D000328:Adult; D000420:Albuterol / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002140:California; D004804:Eosinophils / Q000473:pathology; D005390:Fires; D005541:Forced Expiratory Volume; D006801:Humans; D052638:Particulate Matter / Q000009:adverse effects*; D010366:Peak Expiratory Flow Rate; D013183:Sputum / Q000166:cytology
chemical_list: D001993:Bronchodilator Agents; D052638:Particulate Matter; D000420:Albuterol