title: The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose.
abstract: OBJECTIVE
  The aim of this study was to investigate the associative factors of rhabdomyolysis in patients with doxylamine overdose who had normal creatine phosphokinase levels at admission.
  
  
  METHODS
  This study included 169 patients who visited the emergency department of a tertiary teaching hospital after doxylamine overdose between January 1, 1998, and March 31, 2009. Demographic information, clinical variables, and laboratory data were investigated for the associative factors of rhabdomyolysis.
  
  
  RESULTS
  Thirty-five (21%) of the 169 patients developed rhabdomyolysis. Patients who developed rhabdomyolysis differed from those who did not in the amount of doxylamine ingested, sex, heart rate, initial value of serum creatinine, and alanine aminotransferase. In the multivariate regression analysis, the only reliable predictors of rhabdomyolysis were the amount of doxylamine ingested (P = .004) and heart rate (P < .001).
  
  
  CONCLUSIONS
  Observation and laboratory follow-up are required for patients with large reported ingestions or tachycardia on admission, even if their creatine phosphokinase levels were normal.
authors.affiliation: Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.
authors.forename: Han Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Oh
authors.forename: Chun Song
authors.initials: CS
authors.lastname: Youn
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Wee
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Won Jung
authors.initials: WJ
authors.lastname: Jeong
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Jeong
authors.forename: Kyu Nam
authors.initials: KN
authors.lastname: Park
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000506:poisoning*; D016009:Chi-Square Distribution; D003402:Creatine Kinase / Q000097:blood; D004319:Doxylamine / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012372:ROC Curve; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced*; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D000932:Antiemetics; D004319:Doxylamine; D003402:Creatine Kinase