title: [A case of recurrent breast cancer with lung metastasis resection showing four disease-free years under trastuzumab treatment].
abstract: We report a case of recurrent breast cancer with solitary lung metastasis that has shown no recurrence with treatment by trastuzumab alone after partial resection of the right lung upper lobe. A 56-year-old woman, who presented with left breast cancer, underwent quadrantectomy and axillar lymph node dissection in March 2004. Pathological findings were as follows: invasive ductal carcinoma, 3. 7 cm in size, histological grade 3, positive invasion of lymphatic and blood vessels, negative nodal status, negative ER/PgR status, and overexpression of HER2/ neu. She had received adjuvant radiotherapy followed by cyclophosphamide, methotrexate and fluorouracil combination chemotherapy; however, a lung nodule developed 14 months after first operation, which had grown gradually. Partial resection of the lung with thoracoscope assistance revealed metastatic lung cancer from breast cancer. Trastuzumab treatment for 6 months after second operation has maintained no recurrence for 4 years.
authors.affiliation: Dept. of Surgery, Izumi General Medical Center.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Hanada
authors.forename: Nariaki
authors.initials: N
authors.lastname: Tomiyama
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hori
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kusano
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Kosei
authors.initials: K
authors.lastname: Kawata
authors.forename: Ryojin
authors.initials: R
authors.lastname: Uchino
authors.forename: Naomi
authors.initials: N
authors.lastname: Sakashita
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery; D008408:Mastectomy; D008875:Middle Aged; D011013:Pneumonectomy; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068878:Trastuzumab