title: [Correlation between the refractory periods and threshold potentials and the spike programming in cortical neurons].
abstract: OBJECTIVE
  To investigate the intrinsic mechanisms underlying spike programming at pyramidal neurons and interneurons in layer II/III of sensorimotor cortex.
  
  
  METHODS
  Electrical signals at the cortical neurons were recorded in current clamp model with multi-clamp700B Amplifiers. Signals were inputted into pClamp and Origin for data acquisition and analyses.
  
  
  RESULTS
  Compared to pyramidal neurons, interneurons express the higher capacity of spikes and the more stability of spike programming, which are mechanistically caused by lower threshold potentials and shorter refractory periods.
  
  
  CONCLUSIONS
  The refractory periods and threshold potentials directly influence the programming of sequential spikes.
authors.affiliation: State Key Lab for Brain and Cognitive Sciences, National Lab for Protein Sciences, Institute of Biophysics Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Ying-Liang
authors.initials: YL
authors.lastname: Wu
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D004056:Differential Threshold / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012032:Refractory Period, Electrophysiological / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology