title: New furin inhibitors based on weakly basic amidinohydrazones.
abstract: A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with K(i) values of 0.46 and 0.59μM, respectively. In contrast to inhibitor 17, which still contains a guanidino residue, compound 21 possesses only weakly basic amidinohydrazone groups.
authors.affiliation: Department of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, D-35032 Marburg, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Sielaff
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Than
authors.forename: Dorian
authors.initials: D
authors.lastname: Bevec
authors.forename: Iris
authors.initials: I
authors.lastname: Lindberg
authors.forename: Torsten
authors.initials: T
authors.lastname: Steinmetzer
mesh_terms: D000578:Amidines / Q000737:chemistry* / Q000494:pharmacology*; D045683:Furin / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D000578:Amidines; D006835:Hydrazones; D045683:Furin