title: Hepatic artery thrombosis following pediatric liver transplantation: Assessment of blood flow measurement in allografts.
abstract: The purpose of this study was to define parameters which could be predictive of hepatic artery thrombosis, which continues to be a major complicating factor in pediatric liver transplantation. The hepatic blood flow of 14 pediatric liver patients (15 grafts) who weighed less than 15 kg was measured electromagnetically during orthotopic liver transplantation. The results of blood flow determination and the clinical data in 7 patients (8 grafts) who developed hepatic artery thrombosis were compared with those of 7 control patients. All patients with a hepatic arterial flow of less than 60 ml/min developed hepatic artery thrombosis (4/8 vs. 0/7; p < 0.05), and the patients with hepatic artery thrombosis exhibited higher total hepatic and portal vein flow per 100 gram of liver tissue (262 vs. 136 ml/min; p < 0.001 and 222 vs. 80 ml/min; p < 0.025, respectively) as well as longer cold preservation time (384 vs. 326 min; p < 0.025). The results of our study suggest that hepatic arterial flows of less than 60 ml/min are critical for the development of hepatic artery thrombosis, and that portal venous overflow and increased preservation times may contribute to the development of hepatic artery thrombosis.
authors.affiliation: Department of Surgery, University of Pittsburgh Health Center, Pittsburgh, Pennsylvania, U.S.A.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
authors.forename: Leonard
authors.initials: L
authors.lastname: Makowka
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Carlos O
authors.initials: CO
authors.lastname: Esquivel
authors.forename: James S
authors.initials: JS
authors.lastname: Bowman
authors.forename: Satoru
authors.initials: S
authors.lastname: Todo
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Tzakis
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Starzl