title: [Genetic polymorphisms of IL-6 gene promoter-572C/G in Han population with cerebral infarction of Tangshan area].
abstract: OBJECTIVE
  To study the genetic polymorphisms of IL-6 gene promoter-572C/G in Han population with cerebral infarction of Tangshan area.
  
  
  METHODS
  The IL-6 gene promoter-572C/G polymorphism were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis among 157 cases with cerebral infarction.
  
  
  RESULTS
  In Hans population with cerebral infarction and healthy controls, the frequencies of C allele was higher than that of G allele. The genotype distribution of IL-6 gene promoter-572C/G fitted Hardy-Weinberg balance. The distributions of genotype and alleles were not different between female and male.
  
  
  CONCLUSIONS
  The IL-6 gene site exists -572C/G polymorphism among Han population with cerebral infarction of Tangshan area. C allele is common gene and G allele rare gene.
authors.affiliation: Tangshan People Hospital, Tangshan, China. tsliudongfang@163.com
authors.forename: Liu
authors.initials: L
authors.lastname: Dong-fang
authors.forename: Chen
authors.initials: C
authors.lastname: Nai-yao
authors.forename: Wang
authors.initials: W
authors.lastname: Da-li
authors.forename: Zhang
authors.initials: Z
authors.lastname: Cheng-xia
authors.forename: Zhang
authors.initials: Z
authors.lastname: Bao-qin
mesh_terms: D044466:Asian People; D002544:Cerebral Infarction / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D020521:Stroke / Q000235:genetics*
chemical_list: D015850:Interleukin-6