title: Decreased glucagon-like peptide-1 receptor immunoreactivity in the dentate granule cell layer from adult in the gerbil hippocampus.
abstract: In this study, we investigated age-related changes in glucagon-like peptide-1 receptor (GLP-1R) immunoreactivity and its protein levels in the gerbil hippocampus during normal aging. In the postnatal month 3 (PM 3) group, GLP-1R immunoreaction was well observed in neurons, especially pyramidal and non-pyramidal cells in the hippocampus proper, and granule and polymorphic cells in the dentate gyrus. In the hippocampus proper, GLP-1R immunoreactivity in neurons was maintained until PM 24. In the dentate gyrus, however, GLP-1R immunoreactivity in granule cells, not polymorphic cells, was hardly detected from PM 6. Western blot analysis also showed that age-dependent change patterns in GLP-1R protein levels in the gerbil hippocampus were similar to the immunohistochemical changes. These results indicate that GLP-1R immunoreactivity was markedly decreased in dentate granule cells from PM 6, showing that GLP-1R immunoreactivity and its protein levels were decreased in the adult and aged gerbil hippocampus.
authors.affiliation: Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, South Korea.
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Pan Dong
authors.initials: PD
authors.lastname: Ryu
authors.forename: Joon Ha
authors.initials: JH
authors.lastname: Park
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Sookon
authors.initials: S
authors.lastname: Kim
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Young-Myeong
authors.initials: YM
authors.lastname: Kim
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology* / Q000378:metabolism; D005849:Gerbillinae; D000067757:Glucagon-Like Peptide-1 Receptor; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D018027:Receptors, Glucagon / Q000378:metabolism*
chemical_list: D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon