title: Targeting the protein-protein interactions of the HIV lifecycle.
abstract: The human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), relies heavily on protein-protein interactions in almost every step of its lifecycle. Targeting these interactions, especially those between virus and host proteins, is increasingly viewed as an ideal avenue for the design and development of new therapeutics. In this tutorial review, we outline the lifecycle of HIV and describe some of the protein-protein interactions that control and regulate each step of this process, also detailing efforts to develop therapies that target these interactions.
authors.affiliation: University of Southampton, Southampton, SO17 1BJ, UK. a.tavassoli@soton.ac.uk
authors.forename: Ali
authors.initials: A
authors.lastname: Tavassoli
mesh_terms: D006678:HIV / Q000201:enzymology / Q000378:metabolism*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry; D019427:HIV Integrase / Q000737:chemistry; D016333:HIV Protease / Q000737:chemistry / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000737:chemistry; D054298:Human Immunodeficiency Virus Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D014779:Virus Replication
chemical_list: D015699:HIV Envelope Protein gp120; D054298:Human Immunodeficiency Virus Proteins; D019427:HIV Integrase; D054303:HIV Reverse Transcriptase; D016333:HIV Protease