title: Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action.
abstract: Precursor-fed cultivation of endophytic Chaetomium globosum 1C51 afforded nine novel "unnatural" halogenated chaetoglobosins including those with more preferable immunosuppressive activity.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.forename: Zhi Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Qiong
authors.initials: Q
authors.lastname: Luo
authors.forename: Rui
authors.initials: R
authors.lastname: Feng
authors.forename: Le Yun
authors.initials: le Y
authors.lastname: Zang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Rui Hua
authors.initials: RH
authors.lastname: Jiao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xu
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002597:Chaetomium / Q000737:chemistry; D054879:Halogenation; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D051379:Mice
chemical_list: D007166:Immunosuppressive Agents; D026121:Indole Alkaloids; C019290:chaetoglobosins