title: Searching for the holy grail of a staphylococcal vaccine.
abstract: The pursuit of an effective staphylococcal vaccine has never been more critical, as community-associated MRSA has become the most common bacterial infection in the US. In this commentary, we will highlight new discoveries in the host response to colonization and infection with S. aureus, discuss potential antigens that might be used as vaccines, and make recommendations as to how the field can move forward towards discovering the "holy grail" of an effective staphylococcal vaccine.
authors.affiliation: Department of Pediatrics, Division of Pediatric Infectious Diseases and Vanderbilt Vaccine Research Program, Vanderbilt University School of Medicine and Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
authors.forename: Isaac
authors.initials: I
authors.lastname: Thomsen
authors.forename: Hannah
authors.initials: H
authors.lastname: Dudney
authors.forename: C Buddy
authors.initials: CB
authors.lastname: Creech
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology; D035843:Biomedical Research / Q000639:trends; D002353:Carrier State / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000472:pathogenicity; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D013209:Staphylococcal Vaccines / Q000276:immunology*; D014481:United States / Q000453:epidemiology
chemical_list: D000942:Antigens, Bacterial; D013209:Staphylococcal Vaccines