title: The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity.
authors.affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Krishna Mohan
authors.initials: KM
authors.lastname: Bajjuri
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Sinha
mesh_terms: D062365:Aminobenzoates / Q000008:administration & dosage / Q000138:chemical synthesis; D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D045744:Cell Line, Tumor; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000517:prevention & control; D009842:Oligopeptides / Q000008:administration & dosage / Q000138:chemical synthesis; D011355:Prodrugs / Q000008:administration & dosage / Q000138:chemical synthesis; D047368:Tumor Burden / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects; D000099240:Asparaginyl Endopeptidase
chemical_list: D062365:Aminobenzoates; D003546:Cysteine Endopeptidases; D009842:Oligopeptides; D011355:Prodrugs; D000099240:Asparaginyl Endopeptidase; C543533:auristatin