title: Antiamnestic effects of antibodies to glutamate in experimental Alzheimer's disease.
abstract: Experiments on rats showed that neurodegenerative brain damage caused by administration of neurotoxic fragment of β-amyloid protein Aβ25-35 in a dose of 2 μg into Meynert giant cell nucleus leads to long-term memory impairment in rats. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage restores learning capacity of the experimental animals in the conditioned passive avoidance paradigm.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Gorbatov
authors.forename: N A
authors.initials: NA
authors.lastname: Trekova
authors.forename: V G
authors.initials: VG
authors.lastname: Fomina
authors.forename: T V
authors.initials: TV
authors.lastname: Davydova
mesh_terms: D000281:Administration, Intranasal; D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy*; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D001362:Avoidance Learning / Q000187:drug effects; D018698:Glutamic Acid / Q000276:immunology*; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016229:Amyloid beta-Peptides; D000906:Antibodies; D018698:Glutamic Acid