title: [Molecular actors in Alzheimer's disease: which diagnostic and therapeutic consequences?].
abstract: Alzheimer's disease is a neurodegenerative disorder characterized by neuropathological lesions: amyloid deposits and neurofibrillary degeneration. However, the links between these two brain hallmarks are still poorly understood. Until now, mainly amyloid pathology has been targeted un many clinical trials without any success. Both new therapeutic strategies and diagnosis improvement are needed.
authors.affiliation: Inserm U837, Place de Verdun, Lille, France. luc.buee@inserm.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Buée
authors.forename: David
authors.initials: D
authors.lastname: Blum
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bombois
authors.forename: Valérie
authors.initials: V
authors.lastname: Buée-Scherrer
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Caillet-Boudin
authors.forename: Morvane
authors.initials: M
authors.lastname: Colin
authors.forename: Vincent
authors.initials: V
authors.lastname: Deramecourt
authors.forename: Claire-Marie
authors.initials: CM
authors.lastname: Dhaenens
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Galas
authors.forename: Malika
authors.initials: M
authors.lastname: Hamdane
authors.forename: Sandrine
authors.initials: S
authors.lastname: Humez
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Maurage
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.forename: Bernard
authors.initials: B
authors.lastname: Sablonnière
authors.forename: Susanna
authors.initials: S
authors.lastname: Schraen-Maschke
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sergeant
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D006801:Humans; D016874:Neurofibrillary Tangles / Q000473:pathology*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor