title: [A case of duodenal perforation during mFOLFOX6 treatment for metastatic sigmoid colon cancer].
abstract: We present a case of metastatic sigmoid colon cancer causing duodenal perforation during modified FOLFOX6 chemotherapy. The patient was a 68-year-old man who underwent sigmoidectomy for an advanced sigmoid cancer in September 2007. He has been received mFOLFOX6 chemotherapy for multiple liver metastases since January 2009. In March 2010, the patient complained of abdominal pain during the 24th course of chemotherapy, and was admitted to our hospital. On admission, his vital signs were normal, and abdominal findings revealed no peritonitis signs. An abdominal CT scan showed free air and fluid collection on the first day of admission. The patient was diagnosed with gastrointestinal perforation, and underwent emergency operation for abdominal drainage. The leakage of biliary fluids was recognized at the drain to the Winslow postoperatively. It ceased on the 25th admission day, and an upper gastrointestinal examination showed good passage of fluids and no leakage at the duodenum. However, the patient died 36 days after admission from remarkable pleural effusion and respiratory failure.
authors.affiliation: Ichikawa Gastrointestinal Hospital, Juntendo University.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Koichiro
authors.initials: K
authors.lastname: Niwa
authors.forename: Seigo
authors.initials: S
authors.lastname: Ono
authors.forename: Shun
authors.initials: S
authors.lastname: Ishiyama
authors.forename: Kiichi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kamiyama
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Komiyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kojima
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Tomiki
authors.forename: Junji
authors.initials: J
authors.lastname: Ichikawa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004378:Duodenal Diseases / Q000209:etiology*; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology*; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012811:Sigmoid Neoplasms / Q000150:complications* / Q000188:drug therapy*
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil