title: Potassium transport--an update.
abstract: Potassium homeostasis depends on the coordinated interaction between tightly regulated potassium transfer in and out of the extracellular fluid compartment, and renal excretion or retention of potassium. Potassium transport along the nephron involves extensive proximal tubule reabsorption of potassium. Potassium is also reabsorbed along the thick ascending limb of Henle's loop. Regulated potassium secretion, or potassium reabsorption in exchange for hydrogen ions along the connecting tubule and collecting tubule, is responsible for potassium excretion. Renal potassium transport is modulated by potassium intake, several hormones, acid-base factors and distal nephron sodium delivery. WNK family kinases have also emerged as factors regulating sodium and potassium transport in the distal nephron.
authors.affiliation: Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. Gerhard.giebisch@yale.edu
authors.forename: Gerhard H
authors.initials: GH
authors.lastname: Giebisch
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Wang
mesh_terms: D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D017136:Ion Transport; D015778:Minor Histocompatibility Antigens; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D000076204:WNK Lysine-Deficient Protein Kinase 1
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D015778:Minor Histocompatibility Antigens; D015221:Potassium Channels; D017346:Protein Serine-Threonine Kinases; D000076204:WNK Lysine-Deficient Protein Kinase 1; C498743:WNK1 protein, human; C433806:WNK4 protein, human; D011188:Potassium