title: Expression of nervous tissue nuclear protein and glial fibrillary acidic protein during morphogenesis of the neocortex.
abstract: We studied the distribution of glial fibrillary acidic protein (GFAP) and neuron-specific nuclear histone protein NeuN in sulci of the brain cortex during the pre- and postnatal ontogeny. The expression of GFAP during morphogenetic development of the sulci and gyri is cyclic. After functional reorientation of GFAP in human fetuses at weeks 28-30 it ceases to be a marker of morphogenetically active glia and becomes a marker of glial cells exclusively. Redistribution of NeuN expression in different layers of sulci during their formation was found: enhanced expression of NeuN in the cortical layer 6 of sulci and its reduced expression in the upper layers were noted, whereas outside the cortical sulci NeuN expression was similar in all layers. At weeks 24-25 of gestation, NeuN serves as a marker of ingrowth of secondary visual fibers from the dorsal thalamus.
authors.affiliation: Laboratory of Nervous System Development, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. godovalova@inbox.ru
authors.forename: O S
authors.initials: OS
authors.lastname: Godovalova
mesh_terms: D000328:Adult; D034961:Antigens, Nuclear / Q000096:biosynthesis*; D001344:Autopsy; D005260:Female; D005333:Fetus / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis*; D006801:Humans; D007223:Infant; D008875:Middle Aged; D019579:Neocortex / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third
chemical_list: D034961:Antigens, Nuclear; D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; C506808:neuronal nuclear antigen NeuN, human