title: Mechanisms of centrosome separation and bipolar spindle assembly.
abstract: Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly.
authors.affiliation: Department of Medical Oncology, University Medical Center, CG Utrecht, the Netherlands.
authors.forename: Marvin E
authors.initials: ME
authors.lastname: Tanenbaum
authors.forename: René H
authors.initials: RH
authors.lastname: Medema
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002455:Cell Division / Q000502:physiology*; D018385:Centrosome / Q000502:physiology*; D006801:Humans; D016547:Kinesins / Q000502:physiology; D018386:Kinetochores / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology; D009685:Nuclear Envelope / Q000502:physiology; D011418:Prophase / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology*
chemical_list: D020409:Molecular Motor Proteins; D016547:Kinesins