title: [Relationship between paraoxonase/glutathione S-transferase gene polymorphism and health conditions of floriculture farmers].
abstract: OBJECTIVE
  In this study we conducted a cross-sectional study and reported on the distribution of two common genetic polymorphisms of the PON1 gene and two common genetic polymorphisms of the GST gene as well as the association between those polymorphisms and other predictors in a population of floriculture workers from Kunming city.
  
  
  METHODS
  136 pesticide-exposed farmers were recruited. PON1 and GST T1, M1 genotype were determined by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  (1) Compared with exposure group, the GLB in control group was higher (β = -0.16, t = -2.30, P = 0.02), but the A/G in control group was lower (β = 0.14, t = 2.09, P = 0.04); (2) Compared with the persons who carried QQ genotype, the accumulative symptom scores were lower in the persons who carried RR genotype (t = -2.78, P = 0.006); (3) Compared with GST T1 carriers, non-carriers' GLB (β = -0.20, t = -3.01, P = 0.00) and IgG (β = -0.20, t = -3.01, P = 0.00) were higher, but the A/G was lower; (4) The abnormities of cardiograms among people who had been exposed to pesticides were higher compared to people who did not expose to any pesticides (β = 1.147, P = 0.042).
  
  
  CONCLUSIONS
  PON1-192 and GST T1 gene were associated with the farmers health condition after pesticides exposure.
authors.affiliation: Department of Environmental and Occupational Health, School of Public Health, Kunming Medical College, Kunming 650031, China.
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: He
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000383:Agriculture; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010575:Pesticides / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; D005982:Glutathione Transferase; D010575:Pesticides; C413545:glutathione S-transferase T1; C468406:PON1 protein, human