title: The efficacy of Tc-99m sestamibi for sentinel node mapping in breast carcinomas: comparison with Tc-99m antimony sulphide colloid.
abstract: BACKGROUND
  To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel node mapping in breast carcinoma.
  
  
  METHODS
  Fifty patients with early-stage breast cancer were included in our study. 17.5 MBq Tc-99m-MIBI was injected intradermally to 25 patients and the remainders were injected with the same dose of Tc-99m-antimony sulphide colloid. Anterior and lateral static images were taken at 2 minutes. If sentinel lymph node was not detected, delayed imaging by up to 180 minutes was carried out. The patients were operated on 2-4 hours post-injection. Sentinel lymph node biopsy was performed by the aid of gamma probe and blue dye during surgery.
  
  
  RESULTS
  In the Tc-99m-MIBI group, 23 patients had lymph nodes on scintigraphy images, and sentinel nodes were detected during surgery in all 23 patients. In the Tc-99m-antimony sulphide colloid group, 24 patients had lymph nodes on scintigraphy images, and sentinel nodes were identified during surgery in 24 patients.
  
  
  CONCLUSIONS
  We concluded that 99mTc-MIBI is a suitable radiopharmaceutical for sentinel node detection.
authors.affiliation: Nuclear Medicine Research Centre, Faculty of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. sadeghir@mums.ac.ir
authors.forename: Ramin
authors.initials: R
authors.lastname: Sadeghi
authors.forename: Seyed Rasoul
authors.initials: SR
authors.lastname: Zakavi
authors.forename: Mohammad Naser
authors.initials: MN
authors.lastname: Forghani
authors.forename: Kamran
authors.initials: K
authors.lastname: Aryana
authors.forename: Vahid Reza Dabbagh
authors.initials: VR
authors.lastname: Kakhki
authors.forename: Narjes Khatoon
authors.initials: NK
authors.lastname: Ayati
authors.forename: Fatemeh Homaee
authors.initials: FH
authors.lastname: Shandiz
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ghavamnasiri
authors.forename: Mohammed
authors.initials: M
authors.lastname: Keshtgar
mesh_terms: D000328:Adult; D000965:Antimony / Q000008:administration & dosage / Q000737:chemistry*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D003102:Colloids; D005260:Female; D006801:Humans; D007267:Injections; D009367:Neoplasm Staging; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D017556:Technetium Compounds / Q000008:administration & dosage / Q000737:chemistry*; D017256:Technetium Tc 99m Sestamibi / Q000008:administration & dosage
chemical_list: D003102:Colloids; D017556:Technetium Compounds; C019096:technetium Tc 99m antimony sulfide; D017256:Technetium Tc 99m Sestamibi; D000965:Antimony