title: CE-MS for metabolomics: Developments and applications in the period 2008-2010.
abstract: This review provides an update of the state-of-the-art of CE-MS for metabolomic purposes, covering the scientific literature from July 2008 to June 2010. This review describes the different analytical aspects with respect to non-targeted and targeted metabolomics and the new technological developments used in CE-MS for metabolomics. The applicability of CE-MS in metabolomics research is illustrated by examples of the analysis of biomedical and clinical samples, and for bacterial and plant extracts. The relevant papers on CE-MS for metabolomics are comprehensively summarized in a table, including, e.g. information on sample type and pretreatment, and MS detection mode. Future considerations such as challenges for large-scale and (quantitative) clinical metabolomics studies and the use of sheathless interfacing and different ionization techniques are discussed.
authors.affiliation: Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. r.ramautar@lumc.nl
authors.forename: Rawi
authors.initials: R
authors.lastname: Ramautar
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Mayboroda
authors.forename: Govert W
authors.initials: GW
authors.lastname: Somsen
authors.forename: Gerhardus J
authors.initials: GJ
authors.lastname: de Jong
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000378:metabolism; D020811:Biomedical Technology / Q000379:methods*; D001709:Biotechnology / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D055432:Metabolomics / Q000379:methods*; D008829:Microbiology; D010944:Plants / Q000737:chemistry / Q000378:metabolism