title: Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma.
abstract: In this issue of Cancer Cell, Rui et al. identify JAK2 and JMJDC2 as two contiguous, coamplified oncogenes in primary mediastinal B cell and Hodgkin lymphoma. Together, JAK2 and JMJD2C induce major changes in chromatin structure and gene expression. Targeting these proteins with small molecules represents a new avenue for therapy.
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Dong-Joon
authors.initials: DJ
authors.lastname: Min
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Licht