title: Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells.
abstract: Methylmercury is an environmental pollutant that causes severe central nervous system disorders. We searched for transcription factors involved in the development of methylmercury toxicity and found that the decreased expression of a homeobox protein, HOXB13, in HEK293 cells conferred strong resistance to methylmercury.
authors.affiliation: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.
authors.forename: Gi-Wook
authors.initials: GW
authors.lastname: Hwang
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ryoke
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Akira
authors.initials: A
authors.lastname: Naganuma
mesh_terms: D018929:Cell Culture Techniques; D002470:Cell Survival / Q000187:drug effects / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics*; D004785:Environmental Pollutants / Q000633:toxicity*; D020868:Gene Silencing; D057809:HEK293 Cells; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008767:Methylmercury Compounds / Q000633:toxicity*; D034741:RNA, Small Interfering / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection
chemical_list: D004785:Environmental Pollutants; C484414:HOXB13 protein, human; D018398:Homeodomain Proteins; D008767:Methylmercury Compounds; D034741:RNA, Small Interfering; C004925:methylmercuric chloride