title: Neuroprotective properties of l-carnosine in the brain slices exposed to autoblood in the hemorrhagic stroke model in vitro.
abstract: Neuroprotective properties of L-carnosine have been studied in our in vitro model on olfactory cortex slices of hypertensive rats under a long autoblood (blood clot) influence. Application of L-carnosine (5 mg/ml) on slices before autoblood influence leads to restoration of the activity of glutamatergic and GABA-ergic receptors inhibited in the presence of autoblood and interferes with swelling of slices. L-carnosine protects a bioelectric activity of nervous cells in case of long influence of autoblood and also renders an anti edema effect. This model of hemorrhagic stroke may provide a perspective for investigating the mechanisms of neuroprotection.
authors.affiliation: Pavlov Institute Physiology, Russian Academy Sciences, Saint-Petersburg, Russia.
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Khama-Murad
authors.forename: A A
authors.initials: AA
authors.lastname: Mokrushin
authors.forename: L I
authors.initials: LI
authors.lastname: Pavlinova
mesh_terms: D000200:Action Potentials; D000818:Animals; D001777:Blood Coagulation; D001929:Brain Edema / Q000378:metabolism / Q000503:physiopathology; D002336:Carnosine / Q000378:metabolism / Q000494:pharmacology; D055724:Electrophysiological Phenomena / Q000502:physiology; D006973:Hypertension; D020300:Intracranial Hemorrhages / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008867:Microtomy; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D009833:Olfactory Pathways / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D018079:Receptors, GABA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D020521:Stroke / Q000378:metabolism / Q000503:physiopathology; D046509:Tissue Culture Techniques / Q000379:methods*; D014867:Water / Q000032:analysis
chemical_list: D018696:Neuroprotective Agents; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D014867:Water; D002336:Carnosine