title: [Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].
abstract: OBJECTIVE
  To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism.
  
  
  METHODS
  We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism.
  
  
  RESULTS
  Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats.
  
  
  CONCLUSIONS
  Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.
authors.affiliation: Shanghai Institute of Endocrinology, Shanghai Second Medical University, Shanghai 200025.
authors.forename: D S
authors.initials: DS
authors.lastname: Cai
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Luo
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D018891:Dentate Gyrus / Q000378:metabolism*; D005260:Female; D044385:GTP-Binding Protein alpha Subunits / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006624:Hippocampus / Q000378:metabolism*; D007037:Hypothyroidism / Q000235:genetics / Q000378:metabolism*; D017403:In Situ Hybridization; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D044385:GTP-Binding Protein alpha Subunits; D012333:RNA, Messenger; D013963:Thyroid Hormones; C084618:olfactory G protein subunit alpha olf