title: Bayesian ensemble methods for survival prediction in gene expression data.
abstract: BACKGROUND
  We propose a Bayesian ensemble method for survival prediction in high-dimensional gene expression data. We specify a fully Bayesian hierarchical approach based on an ensemble 'sum-of-trees' model and illustrate our method using three popular survival models. Our non-parametric method incorporates both additive and interaction effects between genes, which results in high predictive accuracy compared with other methods. In addition, our method provides model-free variable selection of important prognostic markers based on controlling the false discovery rates; thus providing a unified procedure to select relevant genes and predict survivor functions.
  
  
  RESULTS
  We assess the performance of our method several simulated and real microarray datasets. We show that our method selects genes potentially related to the development of the disease as well as yields predictive performance that is very competitive to many other existing methods.
  
  
  BACKGROUND
  http://works.bepress.com/veera/1/.
authors.affiliation: Pfizer Inc., Groton, CT 06340, USA.
authors.forename: Vinicius
authors.initials: V
authors.lastname: Bonato
authors.forename: Veerabhadran
authors.initials: V
authors.lastname: Baladandayuthapani
authors.forename: Bradley M
authors.initials: BM
authors.lastname: Broom
authors.forename: Erik P
authors.initials: EP
authors.lastname: Sulman
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Aldape
authors.forename: Kim-Anh
authors.initials: KA
authors.lastname: Do
mesh_terms: D001499:Bayes Theorem; D001932:Brain Neoplasms / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D016019:Survival Analysis