title: Facile, rapid, and high-yield synthesis of pillar[5]arene from commercially available reagents and its X-ray crystal structure.
abstract: We monitored the progress of formation of dimethoxypillar[5]arene by size-exclusion chromatography. Surprisingly, the cyclization reaction completely finished in just 3 min. By improving the reaction conditions and purification process, we successfully obtained dimethoxypillar[5]arene in a short time and in high yield (71%) from commercially available reagents. By improving the deprotection reaction of the methoxy moieties, pillar[5]arene was isolated quantitatively. Single crystal X-ray analysis confirmed the structure of pillar[5]arene in the solid state.
authors.affiliation: Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. ogoshi@t.kanazawa-u.ac.jp
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ogoshi
authors.forename: Takamichi
authors.initials: T
authors.lastname: Aoki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kitajima
authors.forename: Shuhei
authors.initials: S
authors.lastname: Fujinami
authors.forename: Tada-aki
authors.initials: TA
authors.lastname: Yamagishi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakamoto