title: Blockade of 5-HT2A/2C-type receptors impairs learning in female rats in the course of estrous cycle.
abstract: We studied the effects of chronic administration (14 days) of agonist of 5-HT2B/2C serotonin receptors m-CPP (0.5 mg/kg subcutaneously) and agonist of 5-HT2A/2C serotonin receptors ketanserin (0.1 mg/kg intraperitoneally) on conditioned reactions in female rats in different phases of the estrous cycle. Passive avoidance (PA) paradigm and Morris water maze were used as behavioral tests. Chronic administration of m-CPP did not affect PA retrieval during the proestrus and estrus phases, but improved the dynamics of spatial learning in Morris water maze in comparison with control rats. Chronic administration of ketanserin uniformly impaired processes of spatial and nonspatial learning in female rats irrespective to the phase of the estrous cycle. A modulating role of 5-HT2A/2C and 5-HT2B/2C serotonin receptors in process of learning in female rats during the key phases of the estrous cycle was demonstrated.
authors.affiliation: Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology Russian Academy of Sciences, St. Petersburg, Russia. julia.fedotova@mail.ru
authors.forename: Yu O
authors.initials: YO
authors.lastname: Fedotova
authors.forename: N E
authors.initials: NE
authors.lastname: Ordyan
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D030762:Estrous Cycle / Q000187:drug effects*; D005260:Female; D007650:Ketanserin / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D018782:Maze Learning / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D044403:Receptor, Serotonin, 5-HT2B / Q000378:metabolism; D044405:Receptor, Serotonin, 5-HT2C / Q000378:metabolism*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology
chemical_list: D010879:Piperazines; D044402:Receptor, Serotonin, 5-HT2A; D044403:Receptor, Serotonin, 5-HT2B; D044405:Receptor, Serotonin, 5-HT2C; D058826:Serotonin 5-HT2 Receptor Agonists; D007650:Ketanserin; C015068:1-(3-chlorophenyl)piperazine