title: The new bronchopulmonary dysplasia.
abstract: OBJECTIVE
  Bronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth. A number of recent animal models and clinical studies provide new information about pathophysiology and treatment.
  
  
  RESULTS
  The epidemiology of BPD continues to demonstrate that birth weight and gestational age are most predictive of BPD. Correlations of BPD with chorioamnionitis are clouded by the complexity of the fetal exposures to inflammation. Excessive oxygen use in preterm infants can increase the risk of BPD but low saturation targets may increase death. Numerous recent trials demonstrate that many preterm infants can be initially stabilized after delivery with continuous positive airway response (CPAP) and then be selectively treated with surfactant for respiratory distress syndrome. The growth of the lungs of the infant with BPD through childhood remains poorly characterized.
  
  
  CONCLUSIONS
  Recent experiences in neonatology suggest that combining less invasive care strategies that avoid excessive oxygen and ventilation, decrease postnatal infections, and optimize nutrition may decrease the incidence and severity of BPD.
authors.affiliation: Cincinnati Children's Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229-3039, USA. alan.jobe@cchmc.org
authors.forename: Alan H
authors.initials: AH
authors.lastname: Jobe
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D002821:Chorioamnionitis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D039902:Multipotent Stem Cells / Q000637:transplantation; D009569:Nitric Oxide / Q000627:therapeutic use; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects; D011247:Pregnancy; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*
chemical_list: D009569:Nitric Oxide