title: Minimally invasive procedures for evacuation of intracerebral hemorrhage reduces perihematomal glutamate content, blood-brain barrier permeability and brain edema in rabbits.
abstract: BACKGROUND
  To observe the effects of the minimally invasive removal of an intracerebral hematoma on the glutamate concentration, blood-brain barrier (BBB) permeability and brain water content in the brain tissue surrounding the hematoma and to provide a theoretical basis for minimally invasive removal of intracerebral hematomas.
  
  
  METHODS
  Thirty rabbits (2.8-3.4 kg body weight) were selected to establish a model of intracerebral hemorrhage, and they were randomly divided into a model control group and a minimally invasive group after the model was prepared successfully. The intracerebral hematoma was evacuated by stereotactic procedures in minimally invasive group 6 h after the model was established. The glutamate content, the permeability of the BBB and the brain water content in perihematomal brain tissues were determined and compared between the two groups.
  
  
  RESULTS
  The glutamate content, the permeability of the BBB and the brain water content in the perihematomal brain tissues were significantly decreased compared to the model control group 1, 3, and 7 days after the minimally invasive removal of the intracerebral hematoma.
  
  
  CONCLUSIONS
  Minimally invasive surgery for removal of an intracerebral hematoma could significantly reduce the glutamate content, BBB permeability and the brain water content in perihematomal brain tissues.
authors.affiliation: Department of Emergency, Affiliated Hospital, Guiyang Medical College, Guiyang City, Guizhou Province, China. wuguofeng3013@sina.com
authors.forename: Guofeng
authors.initials: G
authors.lastname: Wu
authors.forename: Chang
authors.initials: C
authors.lastname: Li
authors.forename: Likun
authors.initials: L
authors.lastname: Wang
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Mao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D001929:Brain Edema / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D002543:Cerebral Hemorrhage / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006406:Hematoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D019635:Neurosurgical Procedures / Q000379:methods*; D011817:Rabbits; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D018698:Glutamic Acid