title: IRBIT: it is everywhere.
abstract: IRBIT (IP(3)Rs binding protein released with IP(3)) is a protein originally identified by the Mikoshiba group as an inhibitor of IP(3) receptors function. Subsequently it was found to have multiple functions and regulate the activity of diverse proteins, including regulation of HCO(3)(-) transporters to coordinate epithelial HCO(3)(-) secretion and to determine localization of the Fip1 subunit of the CPSF complex to regulate mRNA processing. This review highlights the remarkably divers functions of IRBIT that are likely only a fraction of all the potential functions of this protein.
authors.affiliation: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda, MD 20892, USA.
authors.forename: Dongki
authors.initials: D
authors.lastname: Yang
authors.forename: Nikolay
authors.initials: N
authors.lastname: Shcheynikov
authors.forename: Shmuel
authors.initials: S
authors.lastname: Muallem
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D003713:Dendritic Cells / Q000502:physiology; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000502:physiology*; D037181:Lectins, C-Type / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D027982:Sodium-Bicarbonate Symporters / Q000502:physiology
chemical_list: D001639:Bicarbonates; C470184:CLECL1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D037181:Lectins, C-Type; D008565:Membrane Proteins; C498899:Slc4a4 protein, mouse; D027982:Sodium-Bicarbonate Symporters