title: [Sero-epidemiologic investigation on tick-borne diseases of humans and domestic animals in Zhejiang province].
abstract: OBJECTIVE
  To investigate the seroprevalence of tick-borne diseases in humans and domestic animals from rural areas of Zhejiang province.
  
  
  METHODS
  Anji county, Jindong district and Tiantai county were selected for samples collection according to their geographic locations and historical prevalence of tick-borne diseases. Blood samples of humans and domestic animals were collected in the three sites. An indirect immuno-fluorescent antibody test was used to determine the presence of IgG antibodies of Rickettsiae heilongjiangii, Orientia tsutsugamushi, R. typhi, Anaplasma phagocytosis, Ehrlichia chaffeensis, Bartonella, R. hainan and Coxiella burnetii in these samples.
  
  
  RESULTS
  Six hundred and eighty-three blood samples including 579 from humans and 104 from domestic animals (53 from cattles and 51 from sheep) were collected from the three sites. Antibody positive rates of Orientia tsutsugamushi, R. typhi, Ehrlichia chaffeensis and Coxiella burnetii were significantly different between these sites. IgG from all the 8 pathogens were detected in samples from humans. It was found that the sero-prevalence rates of R. typhi, Bartonella and C. burnetii (20.7%, 10.9%, 5.5%) of adults were higher than those of other Rickettsiae under investigation. The seroprevalence of R. typhi increased along with age. IgG from the 7 pathogens were detected in samples from domestic animals except for Anaplasma phagocytosis. The sero-prevalence rates of R. typhi, Bartonella and R. hainan (69.2%, 51.0%, 22.1%) of adults were higher than those of other Rickettsiae investigated.
  
  
  CONCLUSIONS
  Tick-borne diseases did spread widely in humans and domestic animals from different rural areas of Zhejiang province. The sero-prevalence rates of R. typhi, B. henselae, R. hainan and C. burnetii were higher than that from other pathogens.
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. chlchai@yahoo.cn
authors.forename: Cheng-liang
authors.initials: CL
authors.lastname: Chai
authors.forename: Qun-ying
authors.initials: QY
authors.lastname: Lu
authors.forename: Ji-min
authors.initials: JM
authors.lastname: Sun
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Jiang
authors.forename: Feng
authors.initials: F
authors.lastname: Ling
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Shou-gui
authors.initials: SG
authors.lastname: Zheng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Ge
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001473:Bartonella / Q000276:immunology / Q000302:isolation & purification; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012281:Rickettsia / Q000276:immunology / Q000302:isolation & purification; D016036:Seroepidemiologic Studies; D012756:Sheep; D017282:Tick-Borne Diseases / Q000453:epidemiology* / Q000662:veterinary*; D013987:Ticks / Q000382:microbiology; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial