title: Pyogenic liver abscess and peritonitis due to Rhizopus oryzae in a child with Papillon-Lefevre syndrome.
abstract: Papillon-Lefevre syndrome (PLS) is an autosomal recessive disease that is characterized by symmetric palmoplantar keratodermatitis and severe periodontal destruction. Mutations in the cathepsin C gene (CTSC) have recently been detected in PLS. Immune dysregulation, due to a mutation in CTSC, increases the risk of pyogenic infections in PLS patients. A child with PLS is presented here with liver abscesses and peritonitis caused by Rhizopus oryzae. His liver abscess and peritonitis were cured with amphotericin B without surgical care. This is the first case in the literature liver abscess due to Rhizopus oryzae in a child with PLS.
authors.affiliation: Department of Pediatric Gastroenterology, Faculty of Medicine, Gazi University, Besevler, 06500, Ankara, Turkey.
authors.forename: Buket
authors.initials: B
authors.lastname: Dalgic
authors.forename: Aysegul
authors.initials: A
authors.lastname: Bukulmez
authors.forename: Sinan
authors.initials: S
authors.lastname: Sari
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D006801:Humans; D046290:Liver Abscess, Pyogenic / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D009091:Mucormycosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D010214:Papillon-Lefevre Disease / Q000175:diagnosis*; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology*; D012233:Rhizopus / Q000302:isolation & purification*; D016896:Treatment Outcome
chemical_list: D000666:Amphotericin B