title: Fungal sepsis: optimizing antifungal therapy in the critical care setting.
abstract: Invasive fungal infections (IFI) and fungal sepsis in the intensive care unit are increasing and are associated with considerable morbidity and mortality. In this setting, IFI are predominantly caused by Candida species. Outcomes continue to be suboptimal; however, there are a few key clinician modifiable factors. PK-PD studies with the approved antifungal agents have provided guidance on the dosing strategy that predicts improved outcome. In addition, time to therapy is a critical element. Therefore early recognition through improved risk factor analysis and diagnostics will be key developments. Source control for infected devices and endophthalmitis must be considered.
authors.affiliation: University of Wisconsin, MFCB, Room 5218, 1685 Highland Avenue, Madison, WI 53705-2281, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Lepak
authors.forename: David
authors.initials: D
authors.lastname: Andes
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002175:Candida / Q000187:drug effects; D058387:Candidemia / Q000188:drug therapy; D003422:Critical Care / Q000379:methods*; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007362:Intensive Care Units
chemical_list: D000935:Antifungal Agents