title: [Mediation of abdominal obesity on the association between cigarette smoking and β-cell function].
abstract: OBJECTIVE
  To confirm the effect of cigarette smoking on β-cell function, and further investigate the mediation effect of abdominal obesity.
  
  
  METHODS
  Participants would include 1440 Chinese smokers who had participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. They were interviewed with structured questionnaire on their socio-demographic status and smoking behaviors. Waist-to-hip ratio (WHR) and fasting serum C-peptide concentration were also measured.
  
  
  RESULTS
  After adjustment for the potential confounding factors, when compared with smokers with consumption 1 - 10 cigarettes/day, smokers with consumption of 11 - 20 cigarettes/day (adjusted OR = 1.53, 95%CI: 1.22 - 1.90) or > 20 cigarettes/day (adjusted OR = 1.92, 95%CI: 1.32 - 2.79) had significant higher risks to get C-peptide concentration larger than its median. Furthermore, 37.54% of the effect of cigarette smoking on C-peptide concentration was partially mediated by abdominal obesity.
  
  
  CONCLUSIONS
  Cigarette smoking might be a risk factor for β-cell dysfunction and abdominal obesity.
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Quan
authors.initials: Q
authors.lastname: Qiu
authors.forename: Li-li
authors.initials: LL
authors.lastname: Tan
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xue-qing
authors.initials: XQ
authors.lastname: Yu
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Sun
authors.forename: Wei-qing
authors.initials: WQ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D050417:Insulin-Secreting Cells; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000453:epidemiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D055815:Young Adult