title: Systemic lupus erythematosus in a 3-month old male presenting as thrombocytopenia.
abstract: We report a case of a 3-month old male infant, born to a mother with a known history of systemic lupus erythematosus (SLE). The infant initially presented with petechiae, anemia, and thrombocytopenia. His evaluation revealed antinuclear antibody (ANA) titer of 1 : 160, negative anti-SS-A/SS-B antibody, positive anti-Smith antibody, elevated anti-dsDNA titer, and a slightly low C4 level. His subsequent development of hematuria with nephrotic grade proteinuria fulfilled criteria for a diagnosis of SLE. His condition improved with corticosteroids, mycophenolate mofetil and low-dose aspirin. At 18 months of age, he is clinically well, off all immunosuppression with normal growth parameters and no detectable autoantibodies.
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Dang Do
authors.forename: R A
authors.initials: RA
authors.lastname: Umoren
authors.forename: S E
authors.initials: SE
authors.lastname: Tarvin
authors.forename: B R
authors.initials: BR
authors.lastname: Heilbrunn
authors.forename: A
authors.initials: A
authors.lastname: Mahajerin
authors.forename: S L
authors.initials: SL
authors.lastname: Bowyer
mesh_terms: D001241:Aspirin / Q000008:administration & dosage; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology*
chemical_list: D005343:Fibrinolytic Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011239:Prednisolone; D009173:Mycophenolic Acid; D001241:Aspirin