title: Magnesium-enriched hydroxyapatite at immediate implants: a histomorphometric study in dogs.
abstract: OBJECTIVE
  To evaluate the influence of magnesium-enriched hydroxyapatite (MHA) (SintLife(®)) on bone contour preservation and osseointegration at implants placed immediately into extraction sockets.
  
  
  METHODS
  In the mandibular pre-molar region, implants were installed immediately into extraction sockets of six Labrador dogs. MHA was placed at test sites, while the control sites did not receive augmentation materials. Implants were intended to heal in a submerged mode. After 4 months of healing, the animals were sacrificed, and ground sections were obtained for histomorphometric evaluation.
  
  
  RESULTS
  After 4 months of healing, one control implant was not integrated leaving n=5 test and control implants for evaluation. Both at the test and the control sites, bone resorption occurred. While the most coronal bone-to-implant contact was similar between test and control sites, the alveolar bony crest outline was maintained to a higher degree at the buccal aspect of the test sites (loss: 0.7 mm) compared with the control sites (loss: 1.2 mm), even though this difference did not reach statistical significance.
  
  
  CONCLUSIONS
  The use of MHA to fill the defect around implants placed into the alveolus immediately after tooth extraction did not contribute significantly to the maintenance of the contours of the buccal alveolar bone crest.
authors.affiliation: UNESP - Faculty of Dentistry of Araçatuba, São Paulo State University, Brazil.
authors.forename: Marco
authors.initials: M
authors.lastname: Caneva
authors.forename: Daniele
authors.initials: D
authors.lastname: Botticelli
authors.forename: Edoardo
authors.initials: E
authors.lastname: Stellini
authors.forename: Sergio Luis Scombatti
authors.initials: SL
authors.lastname: Souza
authors.forename: Luiz Antonio
authors.initials: LA
authors.lastname: Salata
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001641:Bicuspid / Q000601:surgery; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002113:Calcification, Physiologic / Q000502:physiology; D003238:Connective Tissue / Q000473:pathology; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D017886:Durapatite / Q000627:therapeutic use*; D057893:Immediate Dental Implant Loading; D017616:Magnesium Compounds / Q000627:therapeutic use*; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D016348:Osseointegration / Q000502:physiology; D013499:Surface Properties; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000473:pathology / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D017616:Magnesium Compounds; D017886:Durapatite