title: Candidate gene association study of magnetic resonance imaging-based hip osteoarthritis (OA): evidence for COL9A2 gene as a common predisposing factor for hip OA and lumbar disc degeneration.
abstract: OBJECTIVE
  To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA).
  
  
  METHODS
  Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed.
  
  
  RESULTS
  Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA.
  
  
  CONCLUSIONS
  The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.
authors.affiliation: Institute for Molecular Medicine Finland (FIMM), Biomedicum Helsinki 2U, University of Helsinki, Helsinki, Finland.
authors.forename: Annu
authors.initials: A
authors.lastname: Näkki
authors.forename: Tapio
authors.initials: T
authors.lastname: Videman
authors.forename: Urho M
authors.initials: UM
authors.lastname: Kujala
authors.forename: Matti
authors.initials: M
authors.lastname: Suhonen
authors.forename: Minna
authors.initials: M
authors.lastname: Männikkö
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: Michele C
authors.initials: MC
authors.lastname: Battié
authors.forename: Jaakko
authors.initials: J
authors.lastname: Kaprio
authors.forename: Janna
authors.initials: J
authors.lastname: Saarela
mesh_terms: D000328:Adult; D000368:Aged; D024081:Collagen Type IX / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000235:genetics / Q000473:pathology; D008159:Lumbar Vertebrae / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D018433:Twin Studies as Topic
chemical_list: C120282:COL9A2 protein, human; D024081:Collagen Type IX