title: Magnetic resonance imaging of intracranial tumors: intra-patient comparison of gadoteridol and ferumoxytol.
abstract: This study aims to compare gadoteridol with ferumoxytol for contrast-enhanced and perfusion-weighted (PW) MRI of intracranial tumors. The final analysis included 26 patients, who underwent 3 consecutive days of 3T MRI. Day 1 consisted of anatomical pre- and postcontrast images, and PW MRI was acquired using gadoteridol (0.1 mmol/kg). On Day 2, the same MRI sequences were obtained with ferumoxytol (510 mg) and on Day 3, the anatomical images were repeated to detect delayed ferumoxytol-induced signal changes. The T₁-weighted images were evaluated qualitatively and quantitatively for enhancement volume and signal intensity (SI) changes; PW data were used to estimate the relative cerebral blood volume (rCBV). All 26 lesions showed 24-hour T₁-weighted ferumoxytol enhancement; 16 also had T₂-weighted hypointensities. In 6 patients, ferumoxytol-induced signal changes were noted in areas with no gadoteridol enhancement. Significantly greater (P< .0001) SI changes were seen with gadoteridol, and qualitative analyses (lesion border delineation, internal morphology, contrast enhancement) also showed significant preferences (P= .0121; P = .0015; P < .0001, respectively) for this agent. There was no significant difference in lesion enhancement volumes between contrast materials. The ferumoxytol-rCBV values were significantly higher (P = .0016) compared with the gadoteridol-rCBV values. In conclusion, ferumoxytol provides important information about tumor biology that complements gadoteridol imaging. The rCBV measurements indicate areas of tumor undergoing rapid growth, whereas the 24-hour scans mark the presence of inflammatory cells. Both of these functions provide useful information about tumor response to treatment. We suggest that dynamic and anatomical imaging with ferumoxytol warrant further assessment in brain tumor therapy.
authors.affiliation: Department of Neurology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, L603, Portland, OR 97239-3098, USA.
authors.forename: Edit
authors.initials: E
authors.lastname: Dósa
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Guillaume
authors.forename: Marianne
authors.initials: M
authors.lastname: Haluska
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Lacy
authors.forename: Bronwyn E
authors.initials: BE
authors.lastname: Hamilton
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Njus
authors.forename: William D
authors.initials: WD
authors.lastname: Rooney
authors.forename: Dale F
authors.initials: DF
authors.lastname: Kraemer
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Muldoon
authors.forename: Edward A
authors.initials: EA
authors.lastname: Neuwelt
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy; D003287:Contrast Media; D005260:Female; D052203:Ferrosoferric Oxide; D005682:Gadolinium; D006397:Hematinics; D006571:Heterocyclic Compounds; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011379:Prognosis; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D006397:Hematinics; D006571:Heterocyclic Compounds; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium; D052203:Ferrosoferric Oxide