title: The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population.
abstract: The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been variably associated with insulin resistance and type 2 diabetes (T2D) in several populations. However, this association has not been studied in Iranian subjects and we hypothesized that the K121Q variant might be associated with T2D and related metabolic traits in this population. The K121Q genotypes were determined by PCR-restriction fragment length polymorphism in 377 normoglycemic controls and 155 T2D patients. T2D patients had significantly higher values for systolic and diastolic blood pressure, BMI, glucose, cholesterol, triglyceride, LDL, apoB, insulin, and HOMA-IR, and lower levels of HDL than the normoglycemic subjects. The frequency of the Q allele did not differ between T2D and normoglycemic subjects (OR 0.96, 95% CI 0.90-2.00, P = 0.70). The Q allele frequency was 16.5% in T2D and 15.2% in normoglycemic subjects. The ENPP1 genotype (KQ + QQ) was not associated with the systolic and diastolic blood pressure, glucose, triglyceride, cholesterol, LDL-C and HDL-C, apo B, BMI, HOMA-IR, and insulin levels in both normoglycemic and T2D groups. Our results suggest that the ENPP1 121Q allele might not be associated with T2D and related metabolic traits among Iranian subjects.
authors.affiliation: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
authors.forename: Hamzeh
authors.initials: H
authors.lastname: Saberi
authors.forename: Narges
authors.initials: N
authors.lastname: Mohammadtaghvaei
authors.forename: Shekufeh
authors.initials: S
authors.lastname: Gulkho
authors.forename: Salar
authors.initials: S
authors.lastname: Bakhtiyari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadi
authors.forename: Parichehr
authors.initials: P
authors.lastname: Hanachi
authors.forename: Siavash
authors.initials: S
authors.lastname: Gerayesh-Nejad
authors.forename: Mehryar
authors.initials: M
authors.lastname: Zargari
authors.forename: Farangis
authors.initials: F
authors.lastname: Ataei
authors.forename: Leila
authors.initials: L
authors.lastname: Parvaneh
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Reza
authors.initials: R
authors.lastname: Meshkani
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution / Q000235:genetics / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D007492:Iran / Q000453:epidemiology; D008239:Lysine / Q000235:genetics; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D010727:Phosphoric Diester Hydrolases / Q000235:genetics* / Q000502:physiology; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011755:Pyrophosphatases / Q000235:genetics* / Q000502:physiology; D055815:Young Adult
chemical_list: D018698:Glutamic Acid; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases; D008239:Lysine