title: Induction of a state of iron limitation in uropathogenic Escherichia coli CFT073 by cranberry-derived proanthocyanidins as revealed by microarray analysis.
abstract: Transcriptional profiles of uropathogenic Escherichia coli CFT073 exposed to cranberry-derived proanthocyanidins (PACs) were determined. Our results indicate that bacteria grown on media supplemented with PACs were iron deprived. To our knowledge, this is the first time that PACs have been shown to induce a state of iron limitation in this bacterium.
authors.affiliation: Dept. of Chemical Engineering, McGill University, Montreal, Quebec H3A 2B2, Canada.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Hidalgo
authors.forename: André
authors.initials: A
authors.lastname: Ponton
authors.forename: Julien
authors.initials: J
authors.lastname: Fatisson
authors.forename: Che
authors.initials: C
authors.lastname: O'May
authors.forename: Bahareh
authors.initials: B
authors.lastname: Asadishad
authors.forename: Tim
authors.initials: T
authors.lastname: Schinner
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tufenkji
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects; D020869:Gene Expression Profiling; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000494:pharmacology*; D046228:Microarray Analysis; D010936:Plant Extracts; D044945:Proanthocyanidins / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D056689:Uropathogenic Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029799:Vaccinium macrocarpon / Q000737:chemistry
chemical_list: D007502:Iron Chelating Agents; D010936:Plant Extracts; D044945:Proanthocyanidins; D007501:Iron