title: Elucidation of the α-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition.
authors.affiliation: Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85748 München, Germany.
authors.forename: Melissa Ann
authors.initials: MA
authors.lastname: Gräwert
authors.forename: Nerea
authors.initials: N
authors.lastname: Gallastegui
authors.forename: Martin
authors.initials: M
authors.lastname: Stein
authors.forename: Boris
authors.initials: B
authors.lastname: Schmidt
authors.forename: Peter-Michael
authors.initials: PM
authors.lastname: Kloetzel
authors.forename: Robert
authors.initials: R
authors.lastname: Huber
authors.forename: Michael
authors.initials: M
authors.lastname: Groll
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001665:Binding Sites; D020134:Catalytic Domain; D003198:Computer Simulation; D003500:Cyclization; D004353:Drug Evaluation, Preclinical; D007659:Ketones / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors; D011485:Protein Binding; D012545:Schiff Bases / Q000737:chemistry
chemical_list: D000447:Aldehydes; D007659:Ketones; D010455:Peptides; D061988:Proteasome Inhibitors; D012545:Schiff Bases; D046988:Proteasome Endopeptidase Complex