title: Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer.
abstract: Cancer risks for a person who has inherited a MUTYH mutation from only one parent (monoallelic mutation carrier) are uncertain. Using the Colon Cancer Family Registry and Newfoundland Familial Colon Cancer Registry, we identified 2,179 first- and second-degree relatives of 144 incident colorectal cancer (CRC) cases who were monoallelic or biallelic mutation carriers ascertained by sampling population complete cancer registries in the United States, Canada and Australia. Using Cox regression weighted to adjust for sampling on family history, we estimated that the country-, age- and sex-specific standardized incidence ratios (SIRs) for monoallelic mutation carriers, compared to the general population, were: 2.04 (95% confidence interval, CI 1.56-2.70; p < 0.001) for CRC, 3.24 (95%CI 2.18-4.98; p < 0.001) for gastric cancer, 3.09 (95%CI 1.07-12.25; p = 0.07) for liver cancer and 2.33 (95%CI 1.18-5.08; p = 0.02) for endometrial cancer. Age-specific cumulative risks to age 70 years, estimated using the SIRs and US population incidences, were: for CRC, 6% (95%CI 5-8%) for men and 4% (95%CI 3-6%) for women; for gastric cancer, 2% (95%CI 1-3%) for men and 0.7% (95%CI 0.5-1%) for women; for liver cancer, 1% (95%CI 0.3-3%) for men and 0.3% (95%CI 0.1-1%) for women and for endometrial cancer, 4% (95%CI 2-8%). There was no evidence of increased risks for cancers of the brain, pancreas, kidney, lung, breast or prostate. Monoallelic MUTYH mutation carriers with a family history of CRC, such as those identified from screening multiple-case CRC families, are at increased risk of colorectal, gastric, endometrial and possibly liver cancers.
authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Parkville, VIC, Australia.
authors.forename: Aung Ko
authors.initials: AK
authors.lastname: Win
authors.forename: Sean P
authors.initials: SP
authors.lastname: Cleary
authors.forename: James G
authors.initials: JG
authors.lastname: Dowty
authors.forename: John A
authors.initials: JA
authors.lastname: Baron
authors.forename: Joanne P
authors.initials: JP
authors.lastname: Young
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Buchanan
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.forename: Terrilea
authors.initials: T
authors.lastname: Burnett
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Parfrey
authors.forename: Roger C
authors.initials: RC
authors.lastname: Green
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Polly A
authors.initials: PA
authors.lastname: Newcomb
authors.forename: Robert W
authors.initials: RW
authors.lastname: Haile
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
authors.forename: Mark A
authors.initials: MA
authors.lastname: Jenkins
mesh_terms: D001315:Australia / Q000453:epidemiology; D002170:Canada / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology; D045647:DNA Glycosylases / Q000235:genetics*; D005190:Family; D005260:Female; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D008297:Male; D009154:Mutation; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics; D012042:Registries; D018570:Risk Assessment; D014481:United States / Q000453:epidemiology
chemical_list: D045647:DNA Glycosylases; C061738:mutY adenine glycosylase