title: [Protective role of endogenous carbon monoxide to lung and kidney tissues during septic shock].
abstract: OBJECTIVE
  To study the protective role of endogenous carbon monoxide to lung and kidney tissues during septic shock and its mechanism.
  
  
  METHODS
  A rat model of CLP was built by using the method of CLP. The malondialdehyde (MDA) content and the activity of superoxide dematase (SOD) in blood, lung and kidney were detected by immunohistochemical technique and light microscope.
  
  
  RESULTS
  Pathological changes of lung and kidney in CLP + Hemin group were lighter than CLP group, inflammatory reaction and lipid peroxidation were also lighter.
  
  
  CONCLUSIONS
  Endogenous CO can protect lung and kidney from the oxidative injury. It can suppress in flammation and the oxidative injury caused by activated inflammatory cells, it is probably an important mechanism of its protective effects.
authors.affiliation: Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Jia-Qing
authors.initials: JQ
authors.lastname: Tan
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Ding
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Suo
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Ling
authors.forename: Xiao-Rao
authors.initials: XR
authors.lastname: Liu
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000502:physiology*; D006427:Hemin / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D015227:Lipid Peroxidation; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000378:metabolism / Q000473:pathology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D008315:Malondialdehyde; D006427:Hemin; D002248:Carbon Monoxide; D013482:Superoxide Dismutase