title: [Effect of bradykinin on the sodium channel current in dorsal root ganglion neuron].
abstract: OBJECTIVE
  To investigate the effects of bradykinin on voltage-dependent sodium channel currents in rat dorsal root ganglion neurons (DRG).
  
  
  METHODS
  Whole-cell patch clamp technique was used to determine sodium channel current.
  
  
  RESULTS
  Bradykinin at 0.01 - 10.0 micromol/L dose dependently increased the frequency of repetitive firing of DRG. Bradykinin at 0.01 - 10.0 micromol/L dose dependently enhanced the TTX-R sodium current, and had no effect on TTX-S sodium current.
  
  
  CONCLUSIONS
  Mechanism underlying the inflammation induced by bradykinin is related to the TTX-R sodium channel.
authors.affiliation: Department of Physiology, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Bi
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Pei
authors.forename: Miao-Zhang
authors.initials: MZ
authors.lastname: Zhu
authors.forename: San-Jue
authors.initials: SJ
authors.lastname: Hu
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*
chemical_list: D015222:Sodium Channels; D001920:Bradykinin