title: CYP2C19 gene polymorphism may be a risk factor for bronchial asthma.
abstract: OBJECTIVE
  The aim of the present study was to investigate whether the genetic polymorphism of CYP2C19 plays a role in susceptibility to bronchial asthma.
  
  
  METHODS
  104 healthy individuals who visited our hospital, including hospital staff, and 97 patients with bronchial asthma (62 atopic and 35 nonatopic) participated in this study. CYPC19*2 and CYP21C9*3 alleles were detected by using LightCycler and CYP2C19 mutation detection kits by real-time PCR with LightCycler.
  
  
  RESULTS
  The CYP2C19*3 genotype was found to be the wild type in all cases, and in the control group, the CYP2C19*2 heterozygous genotype had a 2.46-fold increased risk of bronchial asthmacompared with the CYPC19*2 homozygous wild genotype in the control group(p = 0.01, OR = 2.46, 95% CI 1.24-4.88).
  
  
  CONCLUSIONS
  Our data suggest that the CYP2C19*2 heterozygous genotype may be involved in the development of bronchial asthma.
authors.affiliation: Department of Biochemistry, College of Medicine, Mersin University, Mersin, Turkey. haticeyldrm@yahoo.com
authors.forename: Hatice
authors.initials: H
authors.lastname: Yildirim Yaroğlu
authors.forename: Mukadder
authors.initials: M
authors.lastname: Calikoğlu
authors.forename: Lülüfer
authors.initials: L
authors.lastname: Tamer Gümüş
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D065731:Cytochrome P-450 CYP2C19; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19