title: Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.
abstract: Harnessing the immune system to clear protein aggregates is emerging as a promising approach to treat various neurodegenerative diseases. In Alzheimer's disease (AD), several clinical trials are ongoing using active and passive immunotherapy targeting the amyloid-β (Aβ) peptide. Limited emphasis has been put into clearing tau/tangle pathology, another major hallmark of the disease. Recent findings from the first Aβ vaccination trial suggest that this approach has limited effect on tau pathology and that Aβ plaque clearance may not halt or slow the progression of dementia in individuals with mild-to-moderate AD. To assess within a reasonable timeframe whether targeting tau pathology with immunotherapy could prevent cognitive decline, we developed a new model with accelerated tangle development. It was generated by crossing available strains that express all six human tau isoforms and the M146L presenilin mutation. Here, we show that this unique approach completely prevents severe cognitive impairment in three different tests. This remarkable effect correlated well with extensive clearance of abnormal tau within the brain. Overall, our findings indicate that immunotherapy targeting pathological tau is very feasible for tauopathies, and should be assessed in clinical trials in the near future.
authors.affiliation: Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA.
authors.forename: Allal
authors.initials: A
authors.lastname: Boutajangout
authors.forename: David
authors.initials: D
authors.lastname: Quartermain
authors.forename: Einar M
authors.initials: EM
authors.lastname: Sigurdsson
mesh_terms: D000544:Alzheimer Disease / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000627:therapeutic use; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology / Q000276:immunology / Q000628:therapy; D004268:DNA-Binding Proteins; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005911:Gliosis / Q000209:etiology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000235:genetics / Q000276:immunology; D009154:Mutation / Q000235:genetics / Q000276:immunology*; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism; D063146:Polycomb-Group Proteins; D053764:Presenilin-1 / Q000235:genetics; D011597:Psychomotor Performance / Q000187:drug effects; D021641:Recognition, Psychology / Q000502:physiology; D045442:Rotarod Performance Test; D018709:Statistics, Nonparametric; D014157:Transcription Factors / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D016229:Amyloid beta-Peptides; D000906:Antibodies; D004268:DNA-Binding Proteins; C508853:PSEN1 protein, human; D010446:Peptide Fragments; C533390:Phf1 protein, mouse; D063146:Polycomb-Group Proteins; D053764:Presenilin-1; D014157:Transcription Factors; C075222:amyloid beta-protein (1-42); D016875:tau Proteins