title: Skeletal muscle dysfunction in critical care: wasting, weakness, and rehabilitation strategies.
abstract: Understanding the trajectory of skeletal muscle loss, evaluating its relationship to the subsequent functional impairment, and understanding the underlying mechanisms of skeletal muscle wasting will provide goals for novel treatment strategies in the intensive care setting. A focused approach on the effect of critical illness on muscle morphology, muscle protein turnover, and the associated muscle-signaling pathways during the early and recovery stages of critical illness is required. This could potentially lead to targeted pharmacologic and nonpharmacologic strategies to treat, or even prevent, peripheral muscle wasting and weakness.
authors.affiliation: Lane Fox Respiratory Unit, Guy's and St Thomas' Foundation Trust and Kings College, London, UK.
authors.forename: Zudin
authors.initials: Z
authors.lastname: Puthucheary
authors.forename: Stephen
authors.initials: S
authors.lastname: Harridge
authors.forename: Nicholas
authors.initials: N
authors.lastname: Hart
mesh_terms: D003422:Critical Care; D016638:Critical Illness / Q000534:rehabilitation; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D018908:Muscle Weakness / Q000209:etiology* / Q000517:prevention & control / Q000534:rehabilitation; D018482:Muscle, Skeletal / Q000503:physiopathology; D009133:Muscular Atrophy / Q000209:etiology* / Q000517:prevention & control / Q000534:rehabilitation