title: Familial tendency and risk of nasopharyngeal carcinoma in taiwan: effects of covariates on risk.
abstract: In the present study, the authors compared the long-term risk of nasopharyngeal carcinoma (NPC) of male participants in an NPC multiplex family cohort with that of controls in a community cohort in Taiwan after adjustment for anti-Epstein-Barr virus (EBV) seromarkers and cigarette smoking. A total of 43 incident NPC cases were identified from the 1,019 males in the NPC multiplex family cohort and the 9,622 males in the community cohort, for a total of 8,061 person-years and 185,587 person-years, respectively. The adjusted hazard ratio was 6.8 (95% confidence interval (CI): 2.3, 20.1) for the multiplex family cohort compared with the community cohort. In the evaluation of anti-EBV viral capsid antigen immunoglobulin A and anti-EBV deoxyribonuclease, the adjusted hazard ratios were 2.8 (95% CI: 1.3, 6.0) and 15.1 (95% CI: 4.2, 54.1) for those positive for 1 EBV seromarker and positive for both seromarkers, respectively, compared with those negative for both EBV seromarkers. The adjusted hazard ratio was 31.0 (95% CI: 9.7, 98.7) for participants who reported a family history of NPC and who were anti-EBV-seropositive compared with individuals without such a history who were anti-EBV-seronegative. The findings suggest that both family history of NPC and anti-EBV seropositivity are important determinants of subsequent NPC risk and that the effect of family history on NPC risk cannot be fully explained by mediation through EBV serologic responses.
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors.forename: Wan-Lun
authors.initials: WL
authors.lastname: Hsu
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Yu
authors.forename: Yin-Chu
authors.initials: YC
authors.lastname: Chien
authors.forename: Chun-Ju
authors.initials: CJ
authors.lastname: Chiang
authors.forename: Yu-Juen
authors.initials: YJ
authors.lastname: Cheng
authors.forename: Jen-Yang
authors.initials: JY
authors.lastname: Chen
authors.forename: Mei-Ying
authors.initials: MY
authors.lastname: Liu
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Chou
authors.forename: San-Lin
authors.initials: SL
authors.lastname: You
authors.forename: Mow-Ming
authors.initials: MM
authors.lastname: Hsu
authors.forename: Pei-Jen
authors.initials: PJ
authors.lastname: Lou
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Wang
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Hong
authors.forename: Yi-Shing
authors.initials: YS
authors.lastname: Leu
authors.forename: Ming-Hsui
authors.initials: MH
authors.lastname: Tsai
authors.forename: Mao-Chang
authors.initials: MC
authors.lastname: Su
authors.forename: Sen-Tien
authors.initials: ST
authors.lastname: Tsai
authors.forename: Wen-Yuan
authors.initials: WY
authors.lastname: Chao
authors.forename: Luo-Ping
authors.initials: LP
authors.lastname: Ger
authors.forename: Peir-Rong
authors.initials: PR
authors.lastname: Chen
authors.forename: Czau-Siung
authors.initials: CS
authors.lastname: Yang
authors.forename: Allan
authors.initials: A
authors.lastname: Hildesheim
authors.forename: Scott R
authors.initials: SR
authors.lastname: Diehl
authors.forename: Chien-Jen
authors.initials: CJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D015331:Cohort Studies; D003851:Deoxyribonucleases / Q000097:blood; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology; D014764:Viral Proteins / Q000097:blood
chemical_list: D000956:Antigens, Viral; D014408:Biomarkers, Tumor; D007070:Immunoglobulin A; D014764:Viral Proteins; D003851:Deoxyribonucleases; C083203:deoxyribonuclease, Epstein-Barr virus