title: Proteomic serum biomarkers and their potential application in cancer screening programs.
abstract: Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs.
authors.affiliation: Department of Surgery, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands; E-Mails: a.huijbers@lumc.nl (A.H.); b.velstra@lumc.nl (B.V.); w.e.mesker@lumc.nl (W.E.M.).
authors.forename: Anouck
authors.initials: A
authors.lastname: Huijbers
authors.forename: Berit
authors.initials: B
authors.lastname: Velstra
authors.forename: Tim J A
authors.initials: TJ
authors.lastname: Dekker
authors.forename: Wilma E
authors.initials: WE
authors.lastname: Mesker
authors.forename: Yuri E M
authors.initials: YE
authors.lastname: van der Burgt
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Mertens
authors.forename: André M
authors.initials: AM
authors.lastname: Deelder
authors.forename: Rob A E M
authors.initials: RA
authors.lastname: Tollenaar
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood*; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D040901:Proteomics / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins