title: Hemorheological effects of ortho-isobornyl phenol derivative under conditions of brain ischemia in rats.
abstract: Hemorheological activity of 4-methyl-2,6-di-isobornyl phenol, a new o-isobornyl phenol derivative, was studied under conditions of experimental prolonged partial cerebral ischemia. Brain ischemia is associated with hemorheological disorders which can be characterized as blood hyperviscosity syndrome: increased viscosity of the whole blood (within a wide range of shear rates), plasma viscosity, fibrinogen content in blood plasma, and platelet aggregation; deterioration of platelet deformability and reduced availability of oxygen for tissues. A course (5 days) of intragastric 4-methyl-2,6-di-isobornyl phenol (100 mg/kg) prevented the development of blood hyperviscosity syndrome by modulating blood macrorheology (reduction of plasma viscosity and fibrinogen content) and microrheology (reduction of erythrocyte aggregation and improvement of their deformability).
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, the Russian Academy of Medical Sciences. mbp2001@mail.ru
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: V I
authors.initials: VI
authors.lastname: Smolyakova
authors.forename: I S
authors.initials: IS
authors.lastname: Ivanov
authors.forename: G A
authors.initials: GA
authors.lastname: Chernisheva
authors.forename: A V
authors.initials: AV
authors.lastname: Kuchin
authors.forename: I J
authors.initials: IJ
authors.lastname: Chukicheva
authors.forename: E A
authors.initials: EA
authors.lastname: Krasnov
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D008297:Male; D010636:Phenols / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012212:Rheology
chemical_list: D010636:Phenols