title: Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation.
abstract: We present evidence of hydrogen bond formation, not salt formation, as the driving force in the liquefaction of a solid pharmaceutical in the form of a neutral acid-base complex, as exemplified by the liquid formed from a mixture of the local anesthetic lidocaine with fatty acids; these complexes exist at the boundary between simple eutectics and partially ionised ionic liquids.
authors.affiliation: Institute of Applied Synthetic Chemistry, Vienna University of Technology, 1060 Vienna, Austria. kbica@ioc.tuwien.ac.at
authors.forename: Katharina
authors.initials: K
authors.lastname: Bica
authors.forename: Julia
authors.initials: J
authors.lastname: Shamshina
authors.forename: Whitney L
authors.initials: WL
authors.lastname: Hough
authors.forename: Douglas R
authors.initials: DR
authors.lastname: MacFarlane
authors.forename: Robin D
authors.initials: RD
authors.lastname: Rogers
mesh_terms: D003460:Crystallization; D005227:Fatty Acids / Q000737:chemistry; D006860:Hydrogen Bonding; D052578:Ionic Liquids / Q000737:chemistry; D008012:Lidocaine / Q000737:chemistry; D012492:Salts / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D005227:Fatty Acids; D052578:Ionic Liquids; D012492:Salts; D008012:Lidocaine