title: Continuous flow coupling and decarboxylation reactions promoted by copper tubing.
abstract: A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
authors.affiliation: Novartis Institutes for Biomedical Research Inc., Global Discovery Chemistry, 100 Technology Square, Cambridge, Massachusetts 02139, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Jamison
authors.forename: Sejal
authors.initials: S
authors.lastname: Patel
authors.forename: Nello
authors.initials: N
authors.lastname: Mainolfi
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000295:instrumentation* / Q000379:methods; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: D001555:Benzene Derivatives; D007202:Indicators and Reagents; D003300:Copper