title: Cisplatin and temozolomide combination in the treatment of leptomeningeal carcinomatosis from ethmoid sinus intestinal-type adenocarcinoma.
abstract: Intestinal-type adenocarcinoma of the nasal cavities and paranasal sinuses is a relatively rare tumor. Standard therapeutic modalities include surgery followed by radiotherapy, sometimes with chemotherapy treatment. Despite these treatments, the outcome is poor due to frequent local recurrences constituting the main cause of death among patients; leptomeningeal carcinomatosis is not a frequent event, and its presence indicates short expected survival. The therapy of neoplastic meningitis includes cranial irradiation, intrathecal chemotherapy and high-dose systemic chemotherapy. However, these approaches report important side effects with only modest efficacy. Thus, it is important to discover better treatment for this cancer complication. We present, for the first time, a case of leptomeningeal carcinomatosis from invasive intestinal-type adenocarcinoma treated with temozolomide and cisplatin chemotherapy obtaining a prolonged reduction and stabilization of the lesion improving the clinical condition of the patient.
authors.affiliation: Medical Oncology 1 Unit, Istituto Oncologico Veneto-IRCCS, Via Gattamelata, 64, 35128 Padova, Italy. giuseppe.lombardi@ioveneto.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lombardi
authors.forename: Fable
authors.initials: F
authors.lastname: Zustovich
authors.forename: Alessandro
authors.initials: A
authors.lastname: Della Puppa
authors.forename: Lucia
authors.initials: L
authors.lastname: Borgato
authors.forename: Enrico
authors.initials: E
authors.lastname: Orvieto
authors.forename: Renzo
authors.initials: R
authors.lastname: Manara
authors.forename: Diego
authors.initials: D
authors.lastname: Cecchin
authors.forename: Franco
authors.initials: F
authors.lastname: Berti
authors.forename: Patrizia
authors.initials: P
authors.lastname: Farina
authors.forename: Marina Paolo
authors.initials: MP
authors.lastname: Gardiman
authors.forename: Renato
authors.initials: R
authors.lastname: Scienza
authors.forename: Vittorina
authors.initials: V
authors.lastname: Zagonel
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D055756:Meningeal Carcinomatosis / Q000188:drug therapy* / Q000473:pathology; D013346:Subarachnoid Space / Q000473:pathology; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D002945:Cisplatin; D000077204:Temozolomide