title: High-frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage.
abstract: To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1-3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor with minimized invasiveness and collateral damages.
authors.affiliation: Center for Microwave-Bio Integrated Systems, Department of Electrical Engineering and Computer Science, Institute of New Media and Communications, Seoul National University, Seoul, Korea.
authors.forename: Jeonghoon
authors.initials: J
authors.lastname: Yoon
authors.forename: Jeiwon
authors.initials: J
authors.lastname: Cho
authors.forename: Namgon
authors.initials: N
authors.lastname: Kim
authors.forename: Dae-Duk
authors.initials: DD
authors.lastname: Kim
authors.forename: Eunsook
authors.initials: E
authors.lastname: Lee
authors.forename: Changyul
authors.initials: C
authors.lastname: Cheon
authors.forename: Youngwoo
authors.initials: Y
authors.lastname: Kwon
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D051379:Mice; D008872:Microwaves / Q000009:adverse effects / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D011899:Ranitidine; D014183:Transplantation, Heterologous
chemical_list: D011899:Ranitidine