title: No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women.
abstract: ABCC11 is an ATP-binding cassette transporter responsible for the transport of a diverse range of lipophilic compounds. A single nucleotide polymorphism (SNP) encoding an amino acid change has recently been shown to determine whether cerumen (earwax) is wet or dry. We hypothesised that this ABCC11 SNP may be associated with breast cancer risk because an association has been reported between wet earwax and increased risk of breast cancer. We therefore analysed the frequency of the functional SNP in 1342 cases and 2256 controls from two breast cancer studies of Caucasian women but found no evidence for an association with breast cancer risk.
authors.affiliation: Genetics and Population Health Division, Queensland Institute of Medical Research, Herston, 4006, Brisbane, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Beesley
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Johnatty
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Chen
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Spurdle
authors.forename: Paolo
authors.initials: P
authors.lastname: Peterlongo
authors.forename: Monica
authors.initials: M
authors.lastname: Barile
authors.forename: Valeria
authors.initials: V
authors.lastname: Pensotti
authors.forename: Siranoush
authors.initials: S
authors.lastname: Manoukian
authors.forename: Paolo
authors.initials: P
authors.lastname: Radice
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D016022:Case-Control Studies; D002571:Cerumen; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D044465:White People; D055815:Young Adult
chemical_list: C435500:ABCC11 protein, human; D018528:ATP-Binding Cassette Transporters; D004273:DNA, Neoplasm