title: Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients.
abstract: OBJECTIVE
  Endothelial lipase (EL) is a key enzyme in lipid metabolism, and a polymorphism in the EL gene may be a candidate for modulating lipid parameters in type 2 diabetic (T2D) patients.
  
  
  METHODS
  In 396 T2D patients (age: 59.5 ± 10.7 years; BMI: 28.9 ± 5.3 kg/m(2); HbA(1c): 8.2 ± 1.9%), the c.584C>T polymorphism (rs2000813, p.Thr111Ile) was studied in 225 men (frequency of c.584T: 0.351) and 171 women (frequency of c.584T: 0.304). Patients' metabolic parameters, and macrovascular and microvascular complications, were assessed at baseline and at follow-up (mean: 4.2 years).
  
  
  RESULTS
  Patients who were homozygous for the minor allele displayed modestly decreased low-density lipoprotein (LDL) cholesterol and raised apolipoprotein B at baseline, and raised systolic blood pressure and high-density lipoprotein (HDL) cholesterol on follow-up. Homozygosity for the minor allele was significantly associated with frequency of retinopathy (P=0.025), with TT homozygous patients more likely to have diabetic retinopathy (OR: 3.505; 95% CI: 1.491-8.239) both initially and at follow-up.
  
  
  CONCLUSIONS
  The c.584C>T EL polymorphism is associated with a higher risk of diabetic retinopathy that could be linked to modifications in HDL-cholesterol metabolism and blood pressure levels.
authors.affiliation: Pôle thoracique et cardiovasculaire, hôpital Robert-Debré, CHU de Reims, France. vincent.durlach@univ-reims.fr
authors.forename: V
authors.initials: V
authors.lastname: Durlach
authors.forename: A
authors.initials: A
authors.lastname: Durlach
authors.forename: I
authors.initials: I
authors.lastname: Movesayan
authors.forename: E
authors.initials: E
authors.lastname: Socquard
authors.forename: C
authors.initials: C
authors.lastname: Zellner
authors.forename: C
authors.initials: C
authors.lastname: Clavel
authors.forename: P
authors.initials: P
authors.lastname: Nazeyrollas
authors.forename: M J
authors.initials: MJ
authors.lastname: Malloy
authors.forename: C R
authors.initials: CR
authors.lastname: Pullinger
authors.forename: J P
authors.initials: JP
authors.lastname: Kane
authors.forename: A
authors.initials: A
authors.lastname: Ducasse
authors.forename: B E
authors.initials: BE
authors.lastname: Aouizerat
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000201:enzymology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008049:Lipase / Q000235:genetics* / Q000378:metabolism*; D050356:Lipid Metabolism / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C410382:LIPG protein, human; D008049:Lipase