title: [Treatment of 58 cases of penile squamous cell carcinoma].
abstract: OBJECTIVE
  To search for rational and effective treatments for penile squamous cell carcinoma (PSCC).
  
  
  METHODS
  We retrospectively analyzed the clinical data of 58 cases of pathologically confirmed PSCC, focusing on the treatment methods.
  
  
  RESULTS
  Based on Jackson Staging, 25 of the 58 cases fell into stage I, 18 stage II, 11 stage III, and 4 stage IV. Fifty-three of the patients were treated by surgery, of whom 43 underwent limited resection of the tumor or partial amputation of the penis, and the other 10 received total penis amputation plus perineal urethrostomy and clearance of lymphoglandulae iliacae and inguinal lymph nodes, with the lymphoglandulae iliacae positive in 1 case and the inguinal lymph nodes positive in all. Thirty-seven cases received neoadjuvant hormonal therapy (thermotherapy plus chemotherapy) and combined postoperative chemotherapy, 12 postoperative chemotherapy only, and 4 merely surgery. Five of the total number underwent chemotherapy and/or radiotherapy without surgery. The 2-5 years follow-up of 48 patients found recurrence in 4 cases of partial penis amputation within 2 years, 4 deaths within 2 years, 7 deaths from 2 to 5 years. The 2- and 5-year survival rates were 91.7% and 77.1%, respectively. Ten of the cases were lost in follow-up.
  
  
  CONCLUSIONS
  Surgery + neoadjuvant hormonal therapy + postoperative chemotherapy and/or radiotherapy is an effective method for PSCC, but whether it can reduce the recurrence of PSCC and improve the survival of the patients remains to be further studied.
authors.affiliation: Department of Urology, Zhabei Central Hospital, Shanghai 200070, China. tjmxj@sina.com
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Tan
authors.forename: Xin-liang
authors.initials: XL
authors.lastname: Jin
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
authors.forename: Dan-feng
authors.initials: DF
authors.lastname: Xu
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Zhou
authors.forename: Tao-liang
authors.initials: TL
authors.lastname: Zhang
authors.forename: Jia-jun
authors.initials: JJ
authors.lastname: Xu
authors.forename: Xin-hua
authors.initials: XH
authors.lastname: Fu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome