title: Beta-adrenergic receptors in cancer: therapeutic implications.
abstract: The beta-adrenergic receptors transduce catecholamine signals to the G protein, which through a cascade of chemical reactions in cells generates highly specific parallel signals. The beta2-adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes. Previous studies have determined the relationship of ADRB2 with various aspects related to cancer. Basically, it seems to be related with cell proliferation and apoptosis, chemotaxis, development of metastasis and tumor growth, and angiogenesis. The purpose of this review is to update the implications of these receptors in the pathogenesis of cancer and study the possible application of agonist drugs and/or antagonists in antitumor therapy.
authors.affiliation: Unidad de Medicina Molecular-Fundación Pública Galega de Medicina Xenómica, Edificio de Consultas planta-2, Hospital Clinico Universitario, Santiago de Compostela, Spain. perezsayans@gmail.com
authors.forename: Mario
authors.initials: M
authors.lastname: Pérez-Sayáns
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Somoza-Martín
authors.forename: Francisco
authors.initials: F
authors.lastname: Barros-Angueira
authors.forename: Pilar Gayoso
authors.initials: PG
authors.lastname: Diz
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Gándara Rey
authors.forename: Abel
authors.initials: A
authors.lastname: García-García
mesh_terms: D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D002633:Chemotaxis; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
chemical_list: D011943:Receptors, Adrenergic, beta