title: Nanoparticles for highly efficient multiphoton fluorescence bioimaging.
abstract: In this paper, we demonstrate for the first time that the new class of fluoride-based inorganic upconverting nanoparticles, NaYF4:Er3+, Yb3+, are the most efficient multiphoton excited fluorescent nanoparticles developed to date. The near-infrared-to-visible conversion efficiency of the aforementioned nanoparticles surpasses that of CdSe quantum dots and gold nanorods, which are the commercially available inorganic fluorescent nanoprobes presently used for multiphoton fluorescence bioimaging. The results presented here open new perspectives for the implementation of fluorescence tomography by multiphoton fluorescence imaging.
authors.affiliation: GIEL, Departamento de Física de Materiales, Universidad Autónoma de Madrid, 8049 Madrid, Spain.
authors.forename: Laura Martinez
authors.initials: LM
authors.lastname: Maestro
authors.forename: Emma Martín
authors.initials: EM
authors.lastname: Rodriguez
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Vetrone
authors.forename: Rafik
authors.initials: R
authors.lastname: Naccache
authors.forename: Hector Loro
authors.initials: HL
authors.lastname: Ramirez
authors.forename: Daniel
authors.initials: D
authors.lastname: Jaque
authors.forename: John A
authors.initials: JA
authors.lastname: Capobianco
authors.forename: José García
authors.initials: JG
authors.lastname: Solé
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008163:Luminescent Measurements; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D018036:Selenium Compounds; C058667:cadmium selenide