title: Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives.
abstract: Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID(50)=0.18÷0.72μmol/cm(2)) to that of the reference drug indomethacin (ID(50)=0.23μmol/cm(2)), a non-steroidal anti-inflammatory drug.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università G. D'Annunzio Chieti-Pescara, Via dei Vestini 31, Chieti Scalo (CH) 66013, Italy. fepifano@unich.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Silvio
authors.initials: S
authors.lastname: Sosa
authors.forename: Aurelia
authors.initials: A
authors.lastname: Tubaro
authors.forename: M Carla
authors.initials: MC
authors.lastname: Marcotullio
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001897:Boronic Acids / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use*; D003436:Croton Oil; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001897:Boronic Acids; D003436:Croton Oil; D007213:Indomethacin