title: Self-antigen presentation by dendritic cells and lymphoid stroma and its implications for autoimmunity.
abstract: The induction and maintenance of T cell tolerance is essential to prevent autoimmunity. A combination of central and peripheral mechanisms acts to control autoreactive T cells. In secondary lymphoid organs, dendritic cells (DCs) presenting self-antigen were thought to play a major role in the induction of peripheral T cell tolerance. Multiple recent studies have demonstrated that DCs are not absolutely essential to induce and maintain tolerance. Furthermore, it has also been recently shown that non-hematopoietic stromal cells expressing peripheral tissue-restricted antigens can induce T cell tolerance, independently of DCs. Together these studies imply that peripheral tolerance is more complex than previously thought and a consequence of the tolerogenic functions of the hematopoietic and non-hematopoietic compartments within secondary lymphoid organs.
authors.affiliation: Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA.
authors.forename: Veronika
authors.initials: V
authors.lastname: Lukacs-Kornek
authors.forename: Shannon J
authors.initials: SJ
authors.lastname: Turley
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015551:Autoimmunity; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*; D017154:Stromal Cells / Q000276:immunology*