title: Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease.
abstract: Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-pseudoxanthoma elasticum, acquired cutis laxa, EPS and anetoderma. Herein we present a case of cutis laxa and EPS in a 34-year-old man who was previously on a long-term, high-dose of penicillamine for Wilson's disease. The combination of EPS and cutis laxa induced by penicillamine has rarely been reported and we report the first such case in Korea.
authors.affiliation: Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Korea.
authors.forename: Se Young
authors.initials: SY
authors.lastname: Na
authors.forename: Mira
authors.initials: M
authors.lastname: Choi
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Soyun
authors.initials: S
authors.lastname: Cho