title: Seminoma in a koi carp Cyprinus carpio: histopathological and immunohistochemical findings.
abstract: A spontaneous seminoma in a 3 yr old male koi carp Cyprinus carpio L. is described. The animal, presenting a symmetric abdominal enlargement, showed a celomatic multinodular, white-yellowish and firm mass that infiltrated the liver and the intestine wall. Histologically, the neoplasm was non-encapsulated and poorly demarcated, showed invasive growth and was characterized by a lobular architecture, subdivided by abundant fibro-connective septa. Large necrotic and calcified areas together with small aggregates of residual spermatids were present. We diagnosed a classical seminoma with a diffuse pattern. Neoplastic cells cross-reacted with vimentin, placental alkaline phosphatase, and c-KIT. An immunohistochemical phenotypization of the tumor was performed to exclude other celomatic neoplasms and to compare this seminoma with those reported in mammals and humans.
authors.affiliation: Servizio di Prova di Anatomia Patologica, Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Facoltà di Medicina Veterinaria, Alma Mater Studiorum Università di Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia (BO), Italy. rubina.sirri2@unibo.it
authors.forename: Rubina
authors.initials: R
authors.lastname: Sirri
authors.forename: Luciana
authors.initials: L
authors.lastname: Mandrioli
authors.forename: Valeria
authors.initials: V
authors.lastname: Grieco
authors.forename: Barbara
authors.initials: B
authors.lastname: Bacci
authors.forename: Barbara
authors.initials: B
authors.lastname: Brunetti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sarli
authors.forename: Heike
authors.initials: H
authors.lastname: Schmidt-Posthaus
mesh_terms: D000818:Animals; D002347:Carps; D005393:Fish Diseases / Q000473:pathology*; D008297:Male; D018239:Seminoma / Q000473:pathology / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000473:pathology / Q000662:veterinary*