title: Optimum chemotherapy regimens for neoadjuvant therapy of hepatic colorectal metastases.
abstract: Resection of metastatic colorectal cancer hepatic lesions has gained support as surgical advances have made resections safer. Subsequently, the use of neoadjuvant therapy to cytoreduce tumors coupled with improved medical therapy has enhanced resection rates leading to improved outcomes. In "unresectable" disease, the addition of biologic therapies has further enhanced antitumor response, resulting in successful disease resection in certain patients. This review examines approaches to the neoadjuvant management of colorectal liver metastases with systemic therapies.
authors.affiliation: Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7305, USA.
authors.forename: Janine M
authors.initials: JM
authors.lastname: Davies
authors.forename: Richard M
authors.initials: RM
authors.lastname: Goldberg
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D020360:Neoadjuvant Therapy
chemical_list: D000970:Antineoplastic Agents