title: Comparative tissue distributions of cadmium chloride and cadmium-based quantum dot 705 in mice: Safety implications and applications.
abstract: Cadmium (Cd) is a component in quantum dot 705 (QD705). Whether QD705 behaves similar to Cd in vivo is of great concern. We compared the distributional kinetics of cadmium chloride (CdCl(2)) and QD705 in mice after intravenous injection. QD705 showed a longer plasma and body retention than CdCl(2) and could be detected in the brain during early exposure. While both the liver and spleen demonstrated a constant Cd concentration for 28 days after QD705 injection, it is likely that this represents intact QD705 stored in mononuclear phagocytes. The kidneys showed a time-dependent accumulation of Cd in the QD705-exposed animals. By day 28, Cd in the kidneys from QD705 was 3-fold that of CdCl(2). QD705 and CdCl(2) have very different kinetics in distribution and metabolism. The long body retention of QD705 in the kidneys may mean that QD705 has even more renal toxicity than CdCl(2).
authors.affiliation: Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan.
authors.forename: Teng-Kuang
authors.initials: TK
authors.lastname: Yeh
authors.forename: Jui-Pin
authors.initials: JP
authors.lastname: Wu
authors.forename: Louis W
authors.initials: LW
authors.lastname: Chang
authors.forename: Ming-Hsien
authors.initials: MH
authors.lastname: Tsai
authors.forename: Wan-Hsuan
authors.initials: WH
authors.lastname: Chang
authors.forename: Hui-Ti
authors.initials: HT
authors.lastname: Tsai
authors.forename: Chung Shi
authors.initials: CS
authors.lastname: Yang
authors.forename: Pinpin
authors.initials: P
authors.lastname: Lin
mesh_terms: D000818:Animals; D019256:Cadmium Chloride / Q000493:pharmacokinetics* / Q000633:toxicity; D003952:Diagnostic Imaging / Q000379:methods; D015386:Hazardous Substances / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D053768:Metal Nanoparticles / Q000633:toxicity*; D008668:Metallothionein / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D045663:Quantum Dots; D014018:Tissue Distribution
chemical_list: D015386:Hazardous Substances; D008668:Metallothionein; D019256:Cadmium Chloride