title: Identification of HLA-G*01:17, a new allele possibly generated by an interloci gene conversion event involving exon 3 of HLA-B.
abstract: HLA-G*01:17 was discovered in a woman of Kenyan descent who was enrolled in a mother-to-child HIV-1 transmission cohort. The new allele was identical to HLA-G*01:06 at exons 2, 3, and 4 with the exception of a base pair substitution at codon 169 (CAC → CGC) resulting in a coding change from histidine to arginine and codon 171 (TAC → CAC), resulting in turn in a coding change from tyrosine to histidine. The World Health Organization (WHO) Nomenclature Committee has named this allele HLA-G*01:17.
authors.affiliation: National Microbiology Laboratory, Winnipeg, Manitoba, Canada.
authors.forename: Chris
authors.initials: C
authors.lastname: Czarnecki
authors.forename: Gary
authors.initials: G
authors.lastname: Van Domselaar
authors.forename: Joanne
authors.initials: J
authors.lastname: Embreé
authors.forename: Robert
authors.initials: R
authors.lastname: Brunham
authors.forename: Francis A
authors.initials: FA
authors.lastname: Plummer
authors.forename: Ma
authors.initials: M
authors.lastname: Luo
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6; D005260:Female; D005785:Gene Conversion; D005838:Genotype; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011487:Protein Conformation; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
chemical_list: D006680:HLA Antigens; D015235:HLA-B Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I