title: The beta identity of class I PtdIns3K: A positive role of p110β in autophagy revealed.
abstract: Autophagy is critically controlled by phosphatidylinositol 3-kinases (PtdIns3Ks). The common understanding for mammalian autophagy is that class I PtdIns3Ks inhibit autophagy by activating the Akt-TOR kinase cascade, whereas the class III PtdIns3K (Vps34) promotes autophagy by generating the phospholipid PtdIns(3)P. However, direct genetic evidence for a role of class I PtdIns3Ks in autophagy has been lacking. Using mice with a conditional deletion of the class I PtdIns3K catalytic subunit isoform p110α or p110β, we revealed an unexpected function of p110β as a positive regulator of autophagy.
authors.affiliation: Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Zhixun
authors.initials: Z
authors.lastname: Dou
authors.forename: Ji-An
authors.initials: JA
authors.lastname: Pan
authors.forename: Richard Z
authors.initials: RZ
authors.lastname: Lin
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Zong
mesh_terms: D000818:Animals; D001343:Autophagy; D002460:Cell Line; D058546:Class III Phosphatidylinositol 3-Kinases / Q000378:metabolism; D058543:Class Ia Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D058546:Class III Phosphatidylinositol 3-Kinases; D058543:Class Ia Phosphatidylinositol 3-Kinase; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases