title: [Research advances on associated genes and pathogenesis of hydrocephalus].
abstract: Hydrocephalus is a common medical condition characterized by abnormalities in the secretion,circulation or resorption of cerebrospinal fluid (CSF), resulting in ventricular dilatation. The pathogenetic mechanism for the hydrocephalus is attributed to: the overproduction of CSF by the choroid plexus; the defect in CSF absorption and obstruction of CSF flow in the cerebral ventricles. However, the underlying etiology is poorly understood. With the development of genetic engineering, a growing body of evidence indicates that genetic factors play an essential role in the pathogenesis of hydrocephalus. It is the aim of this review to summarize these findings.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Jia-jun
authors.initials: JJ
authors.lastname: Zhou
authors.forename: Mei-ping
authors.initials: MP
authors.lastname: Ding
authors.forename: Jian-ren
authors.initials: JR
authors.lastname: Liu
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000473:pathology; D004195:Disease Models, Animal; D006849:Hydrocephalus / Q000235:genetics* / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout