title: Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.
abstract: OBJECTIVE
  To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population.
  
  
  METHODS
  Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.
  
  
  RESULTS
  There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10(-12) and 3.0 × 10(-4)) and allelic frequencies (P = 2.3 × 10(-13) and 4.0 × 10(-5)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility.
  
  
  CONCLUSIONS
  This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.
authors.affiliation: Mei-Due Yang, Chao-Hsiang Chang, Hwei-Chung Wang, Department of Surgery, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China.
authors.forename: Mei-Due
authors.initials: MD
authors.lastname: Yang
authors.forename: Ru-Yin
authors.initials: RY
authors.lastname: Tsai
authors.forename: Chiu-Shong
authors.initials: CS
authors.lastname: Liu
authors.forename: Chao-Hsiang
authors.initials: CH
authors.lastname: Chang
authors.forename: Hwei-Chung
authors.initials: HC
authors.lastname: Wang
authors.forename: Yung-An
authors.initials: YA
authors.lastname: Tsou
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Wang
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Song-Kun
authors.initials: SK
authors.lastname: Shyue
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau