title: Androgen deprivation and bone.
abstract: Bone health in men with prostate cancer on androgen deprivation therapy (ADT) has gained increased attention in recent years. Therapies that are becoming available to prevent bone loss and associated complications are changing practice for this patient population. In addition to basic vitamin D and calcium supplementation, bisphosphonates may be an option to treat these patients, and denosumab, a receptor activator of nuclear factor-κB ligand inhibitor, has been proven to be effective in preventing bone loss through a randomized clinical trial. This review examines the importance of bone health in patients on ADT, with an overview of available treatment modalities and guidelines for managing these patients.
authors.affiliation: Departments of Surgery and Urology, Centre Hospitalier de l'Université de Montréal, 1560 Sherbrooke East, Montreal, Quebec H2L 4M1, Canada. jean-baptiste.lattouf@umontreal.ca
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Lattouf
authors.forename: Hicham
authors.initials: H
authors.lastname: Fadlallah
authors.forename: Fred
authors.initials: F
authors.lastname: Saad
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D061067:Antibodies, Monoclonal, Humanized; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D002136:Calcium, Dietary / Q000494:pharmacology; D000069448:Denosumab; D004164:Diphosphonates / Q000494:pharmacology; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D053245:RANK Ligand / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D014807:Vitamin D / Q000494:pharmacology
chemical_list: D000726:Androgen Antagonists; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D004164:Diphosphonates; D053245:RANK Ligand; D014807:Vitamin D; D000069448:Denosumab