title: MicroRNA regulation of core apoptosis pathways in cancer.
abstract: Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear that many miRNAs are anti-apoptotic and mediate this effect by targeting pro-apoptotic mRNAs or positive regulators of pro-apoptotic mRNAs. Conversely, many pro-apoptotic miRNAs target anti-apoptotic mRNAs or their positive regulators. We have reviewed the current knowledge in this area including evidence of miRNA involvement in cancer drug resistance.
authors.affiliation: IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal.
authors.forename: Raquel T
authors.initials: RT
authors.lastname: Lima
authors.forename: Sara
authors.initials: S
authors.lastname: Busacca
authors.forename: Gabriela M
authors.initials: GM
authors.lastname: Almeida
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gaudino
authors.forename: Dean A
authors.initials: DA
authors.lastname: Fennell
authors.forename: M Helena
authors.initials: MH
authors.lastname: Vasconcelos
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000037:antagonists & inhibitors; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000502:physiology; D053453:Caspase 9 / Q000378:metabolism; D015536:Down-Regulation; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D035683:MicroRNAs / Q000502:physiology*; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D010446:Peptide Fragments / Q000378:metabolism; D010750:Phosphoproteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051020:bcl-X Protein / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; C494811:BCL2L1 protein, human; C491073:BCL2L2 protein, human; C474007:Bax protein (53-86); D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; D047908:Intracellular Signaling Peptides and Proteins; D035683:MicroRNAs; D064549:Myeloid Cell Leukemia Sequence 1 Protein; C092039:PEA15 protein, human; D010446:Peptide Fragments; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D051020:bcl-X Protein; D053453:Caspase 9