title: Effect of selective inhibitors of nitric oxide synthesis on the course of experimental hemorrhagic shock.
abstract: Selective inhibitors of NO synthesis (derivatives of lysine, ornithine, and isothiourea) increased the efficiency of infusion therapy for experimental hemorrhagic shock in rats. These changes were related to improvement of cardiac function (increase in stroke volume, cardiac output, and left ventricular efficiency). Among the three inhibitors, N5-(1-iminoethyl)-L-ornithine dihydrochloride was most potent on this experimental model. This compound improved cardiac function and microcirculation and provided 100% survival of experimental animals.
authors.affiliation: Laboratory of Experimental Pathology, Russian Research Institute of Hematology and Transfusion Medicine, Russian Ministry of Health, St. Petersburg, Russia. rnhiit@mail.ru
authors.forename: M I
authors.initials: MI
authors.lastname: Remizova
authors.forename: K A
authors.initials: KA
authors.lastname: Gerbut
authors.forename: N I
authors.initials: NI
authors.lastname: Kochetygov
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007550:Isothiuronium / Q000031:analogs & derivatives / Q000494:pharmacology; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D008833:Microcirculation / Q000187:drug effects; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012771:Shock, Hemorrhagic
chemical_list: D004791:Enzyme Inhibitors; C090663:N(6)-(1-iminoethyl)lysine; D007550:Isothiuronium; C065027:N(G)-iminoethylornithine; D009952:Ornithine; D019001:Nitric Oxide Synthase; C027744:S-methylisothiopseudouronium; D008239:Lysine