title: Neuromotor outcomes in infants with bronchopulmonary dysplasia.
abstract: We examine the neuromotor outcomes of preterm infants with bronchopulmonary dysplasia. Two hundred and nineteen infants (gestational age, ≤ 32 weeks; birth weight, ≤ 1500 g) were studied. Neuromotor development was assessed using the Hammersmith Infant Neurological Examination. All potential risk factors associated with neuromotor scores (P < 0.015) were included in the generalized linear model (multiple linear regression) to determine if bronchopulmonary dysplasia had an independent relationship with neuromotor scores. Infants with severe bronchopulmonary dysplasia had lower global scores at ages 6 and 12 months. After adjustment for confounding factors, scores of infants with severe bronchopulmonary dysplasia were reduced by 13.2 units, whereas scores for those with periventricular leukomalacia were reduced by 11.1 units, at age 6 months. At age 12 months, scores for those with periventricular leukomalacia were reduced by 11.9 units. Duration of hospital stay reduced scores by 0.1 for each additional day increase in hospital. Bronchopulmonary dysplasia constitutes a major cause of poor neuromotor outcomes at age 6 months, but improvements in motor outcomes occur over time.
authors.affiliation: Department of Neonatology and B'NICU, Aristotle University of Thessaloniki, General Papageorgiou Hospital, Thessaloniki, Greece. karagpar@med.auth.gr
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Karagianni
authors.forename: Christos
authors.initials: C
authors.lastname: Tsakalidis
authors.forename: Maria
authors.initials: M
authors.lastname: Kyriakidou
authors.forename: Georgios
authors.initials: G
authors.lastname: Mitsiakos
authors.forename: Helias
authors.initials: H
authors.lastname: Chatziioanidis
authors.forename: Maria
authors.initials: M
authors.lastname: Porpodi
authors.forename: Athanasios
authors.initials: A
authors.lastname: Evangeliou
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Nikolaides
mesh_terms: D001034:Apgar Score; D001997:Bronchopulmonary Dysplasia / Q000150:complications* / Q000503:physiopathology*; D002657:Child Development; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007902:Length of Stay; D007969:Leukomalacia, Periventricular / Q000473:pathology; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology*; D009460:Neurologic Examination; D011446:Prospective Studies; D012307:Risk Factors