title: Intersectin multidomain adaptor proteins: regulation of functional diversity.
abstract: Adaptor/scaffold proteins serve as platforms for the assembly of multiprotein complexes and regulate the efficiency and specificity of signalling cascades. Intersectins (ITSNs) are an evolutionarily conserved adaptor protein family engaged in endo- and exocytosis, actin cytoskeleton rearrangement and signal transduction. This review summarizes recent advances in the function of ITSNs in neuronal and non-neuronal cells, the role of alternative splicing and alternative transcription in regulating the structural and functional diversity of ITSNs, their expression patterns in different tissues and during development, their interactions with proteins, as well as the potential relevance of ITSNs for neurodegenerative diseases and cancer. The diversity of mechanisms in the regulation of ITSN expression and specificity in different cells emphasizes the important role of ITSN proteins in vesicle trafficking and signalling.
authors.affiliation: Department of Functional Genomics, Institute of Molecular Biology and Genetics, NASU, 150 Zabolotnogo Street, Kyiv, Ukraine.
authors.forename: Liudmyla
authors.initials: L
authors.lastname: Tsyba
authors.forename: Oleksii
authors.initials: O
authors.lastname: Nikolaienko
authors.forename: Oleksandr
authors.initials: O
authors.lastname: Dergai
authors.forename: Mykola
authors.initials: M
authors.lastname: Dergai
authors.forename: Olga
authors.initials: O
authors.lastname: Novokhatska
authors.forename: Inessa
authors.initials: I
authors.lastname: Skrypkina
authors.forename: Alla
authors.initials: A
authors.lastname: Rynditch
mesh_terms: D000199:Actins; D033942:Adaptor Proteins, Vesicular Transport / Q000737:chemistry / Q000502:physiology*; D017398:Alternative Splicing; D000818:Animals; D004705:Endocytosis; D005089:Exocytosis; D005786:Gene Expression Regulation; D009474:Neurons / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000199:Actins; D033942:Adaptor Proteins, Vesicular Transport; C115919:intersectin 1; D020794:Receptor Protein-Tyrosine Kinases