title: Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents.
abstract: Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C(16)) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C(16)-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance ((1)H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C(16)-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C(16)-ED-DOTA-Gd.
authors.forename: Sang Young
authors.initials: SY
authors.lastname: Jeong
authors.forename: Hyo Jeong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Byung-Kook
authors.initials: BK
authors.lastname: Kwak
authors.forename: Ha-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Hasoo
authors.initials: H
authors.lastname: Seong
authors.forename: Byung Cheol
authors.initials: BC
authors.lastname: Shin
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Hwang
authors.forename: Sun Hang
authors.initials: SH
authors.lastname: Cho