title: Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease.
abstract: OBJECTIVE
  the association of autosomal-dominant polycystic kidney disease (ADPKD) with intracranial aneurysm (ICAN) is well known but little is known about the characteristics of ICAN in ADPKD. The purpose of this study was to investigate the prevalence and characteristics of ICAN in ADPKD.
  
  
  METHODS
  we screened 355 patients with ADPKD (mean age, 46.5 ± 13.2 years; range, 7 to 87 years) with 3-dimensional time-of-flight MR angiography. Size, location, and morphology of aneurysms were assessed. The prevalence and characteristics of ICAN in patients with ADPKD were evaluated. Patients with ICAN found by MR angiography and moderate renal function subsequently were recommended to undergo digital subtraction angiography for comparison.
  
  
  RESULTS
  the prevalence of ICAN in ADPKD was 12.4% (95% CI, 8.95% to 15.82%) with an equal gender distribution. The prevalence increased as age increased, reaching a peak value of 23.3% (95% CI, 16.85 to 29.75%) in the 60- to 69-year age group. The prevalence of ICAN in patients with ADPKD with a positive family history of hemorrhagic stroke or ICAN was higher than patients with ADPKD lacking such family history (relative risk, 1.968; 95% CI, 1.57 to 2.67). The mean diameter of ICAN was 3.85 ± 3.25 mm. The most frequent site of ICAN was the internal carotid artery. The result of digital subtraction angiography of 15 patients with 18 ICANs and moderate renal function corresponded to the detection of MR angiography.
  
  
  CONCLUSIONS
  the characteristics of ICAN in patients with ADPKD were different from some previous reports. Systematic screening of ICAN with 3-dimensional time-of-flight MR angiography is recommended for patients with ADPKD, particularly for adult patients (≧30 years) or patients with a positive family history of hemorrhagic stroke or ICAN.
authors.affiliation: Institute of Diagnostic and Interventional Radiology, the Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yi Shan Road, ShangHai, China.
authors.forename: H W
authors.initials: HW
authors.lastname: Xu
authors.forename: Sheng Qiang
authors.initials: SQ
authors.lastname: Yu
authors.forename: Chang Lin
authors.initials: CL
authors.lastname: Mei
authors.forename: Ming Hua
authors.initials: MH
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002343:Carotid Artery, Internal / Q000473:pathology / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D007677:Kidney Function Tests; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D015995:Prevalence; D012189:Retrospective Studies