title: Multi-scale model for investigating the electrical properties and mechanical properties of liver tissue undergoing ablation.
abstract: OBJECTIVE
  Radio-frequency (RF) has been used to induce ablation and coagulation in liver for minimizing blood loss during liver resection. A multi-level tissue model that we have developed to investigate the changes in electrical properties of liver tissue during RF ablation.
  
  
  METHODS
  The proposed computational model comprises of an equivalent circuit consisting of resistors and capacitors. The potential difference across the cells and the extracellular structure is used to help predicting the associated changes in tissue electrical property. Experiments were done to validate the proposed model and computer simulation.
  
  
  RESULTS
  The changes in tissue mechanical properties were correlated with that of electrical property using experiments.
  
  
  CONCLUSIONS
  Knowledge of tissue properties changes in associated with changes at the cells and the extracellular structure can be used to optimize RF ablation and tissue division during surgery.
authors.affiliation: Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore. g0800395@nus.edu.sg
authors.forename: Wei-Hsuan
authors.initials: WH
authors.lastname: Huang
authors.forename: Chee-Kong
authors.initials: CK
authors.lastname: Chui
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Swee-Hin
authors.initials: SH
authors.lastname: Teoh
authors.forename: Stephen
authors.initials: S
authors.lastname: Chang
mesh_terms: D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods; D003198:Computer Simulation; D004867:Equipment Design; D004869:Equipment Safety; D006498:Hepatectomy / Q000295:instrumentation / Q000379:methods; D006801:Humans; D021621:Imaging, Three-Dimensional; D008099:Liver / Q000473:pathology / Q000601:surgery*; D008954:Models, Biological; D012680:Sensitivity and Specificity