title: Embolization of polycystic kidneys as an alternative to nephrectomy before renal transplantation: a pilot study.
abstract: In autosomal polycystic kidney disease, nephrectomy is required before transplantation if kidney volume is excessive. We evaluated the effectiveness of transcatheter arterial embolization (TAE) to obtain sufficient volume reduction for graft implantation. From March 2007 to December 2009, 25 patients with kidneys descending below the iliac crest had unilateral renal TAE associated with a postembolization syndrome protocol. Volume reduction was evaluated by CT before, 3, and 6 months after embolization. The strategy was considered a success if the temporary contraindication for renal transplantation could be withdrawn within 6 months after TAE. TAE was well tolerated and the objective was reached in 21 patients. The temporary contraindication for transplantation was withdrawn within 3 months after TAE in 9 patients and within 6 months in 12 additional patients. The mean reduction in volume was 42% at 3 months (p = 0.01) and 54% at 6 months (p = 0.001). One patient required a cyst sclerosis to reach the objective. The absence of sufficient volume reduction was due to an excessive basal renal volume, a missed accessory artery and/or renal artery revascularization. Embolization of enlarged polycystic kidneys appears to be an advantageous alternative to nephrectomy before renal transplantation.
authors.affiliation: Department of Adult Diagnostic and Interventional Imaging, Bordeaux University Hospital, Place Amélie Raba Léon, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Cornelis
authors.forename: L
authors.initials: L
authors.lastname: Couzi
authors.forename: Y
authors.initials: Y
authors.lastname: Le Bras
authors.forename: R
authors.initials: R
authors.lastname: Hubrecht
authors.forename: E
authors.initials: E
authors.lastname: Dodré
authors.forename: M
authors.initials: M
authors.lastname: Geneviève
authors.forename: V
authors.initials: V
authors.lastname: Pérot
authors.forename: H
authors.initials: H
authors.lastname: Wallerand
authors.forename: J M
authors.initials: JM
authors.lastname: Ferrière
authors.forename: P
authors.initials: P
authors.lastname: Merville
authors.forename: N
authors.initials: N
authors.lastname: Grenier
mesh_terms: D000328:Adult; D000368:Aged; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000150:complications; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D016891:Polycystic Kidney, Autosomal Dominant / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome