title: Diagnostic performance of 320-detector CT coronary angiography in patients with atrial fibrillation: preliminary results.
abstract: OBJECTIVE
  To evaluate the feasibility, diagnostic accuracy, and radiation dose of CT coronary angiography (CTCA) in patients with atrial fibrillation (AF) using 320-detector CT.
  
  
  METHODS
  Thirty-seven patients with persistent AF and suspected coronary artery disease (CAD) were enrolled. All patients underwent both 320-detector CTCA and conventional coronary angiography (CCA). CT image quality and the presence of significant (≥ 50%) stenosis were evaluated by two radiologists blinded to the results of CCA. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated using CCA as the reference standard. Differences in detection of coronary artery stenosis between 320-detector CTCA and CCA were evaluated with McNemar's test. Patient radiation dose was calculated by multiplying dose length product by conversion coefficient of 0.017.
  
  
  RESULTS
  In total 474 evaluated coronary segments, 459 (96.8%) segments were diagnostically evaluable. On per-segment analysis, sensitivity, specificity, PPV and NPV were 90.0% (18 of 20), 99.3% (436 of 439), 85.7% (18 of 21) and 99.5% (436 of 438). No significant difference was found between 320-detector CTCA and CCA on the detection of significant stenosis (P = 1.000). Effective doses of 320-detector CTCA was 13.0 ± 4.7 mSv.
  
  
  CONCLUSIONS
  320-detector CTCA is feasible and accurate in excluding CAD in patients with AF.
authors.affiliation: Department of radiology, Beijing Anzhen Hospital, Capital Medical University, No 2, Anzhen Road, Chaoyang District, 100029 Beijing, China. leixu2001@hotmail.com
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Zhanming
authors.initials: Z
authors.lastname: Fan
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Biao
authors.initials: B
authors.lastname: Lv
authors.forename: Zhaoqi
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000000981:diagnostic imaging*; D003251:Constriction, Pathologic; D017023:Coronary Angiography / Q000295:instrumentation* / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011871:Radiology / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods*