title: Effect of steric hindrance on the properties of antibacterial and biocompatible copolymers.
abstract: The development of polymers that are both bactericidal and biocompatible would have many applications and are currently of substantial research interest. It is well known that polymers of alkyl-quaternized poly(4-vinylpyridine) are known to be effective against a wide range of microbes: when copolymerized with monomers that form biocompatible materials, they has also been shown to possess biocompatible properties. However, the relationship of the various physical and chemical properties of these polymers and copolymers with the antibacterial and biocompatible properties remains poorly understood: maximizing the selectivity and performance of these materials is absolutely needed before they have the potential for commercial applications. Maximizing the performance will require a complete understanding of the effect of physical and chemical adjustments on these quaternized polymer bactericides. This article seeks to explore and characterize the effect of one specific property, steric hindrance, on the copolymers' antibacterial and biocompatible properties. We have thus synthesized and characterized a new class of copolymers from 2-vinylpyridine and poly(ethylene glycol) methyl ether methacrylate, measured its bactericidal and biocompatible properties, and compared its performance to chemically similar but sterically different polymer bactericides. This work thereby enables both a greater understanding of the properties of the 2-vinylpyridine copolymers and an improved understanding of the material properties that are vital for the development of antibacterial polymers.
authors.affiliation: School of Materials Engineering, Purdue University, 701 West Stadium Avenue, West Lafayette, Indiana 47907, United States.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Stratton
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Applegate
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Youngblood
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004912:Erythrocytes; D019453:Escherichia coli O157 / Q000254:growth & development*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008422:Materials Testing; D011145:Polyvinyls / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011145:Polyvinyls