title: Behavioral and personality features in patients with lateralized Parkinson's disease.
abstract: BACKGROUND
  Dopamine neurotransmission plays a key role in several brain activities, including motor, cognitive, and behavioral functions. Parkinson's disease (PD) typically begins with asymmetrical motor features related to asymmetrical dopamine denervation. This study was designed to examine whether distinct cognitive, behavioral, and personality features are related to this asymmetry.
  
  
  METHODS
  Fifty-six patients with mild PD and lateralized motor features were grouped according to dominant side of motor features and evaluated using a neuropsychological assessment focused on attention and executive functions, impulse control disorders, and personality inventory.
  
  
  RESULTS
  There were no differences in neuropsychological functions between patients with right and left lateralized PD, but differences occurred in personality features. Patients with motor impairment predominant on the left-hand side had prevalence of hypomania and conversion profile.
  
  
  CONCLUSIONS
  This study suggests that side dominance of dopaminergic denervation may be related to personality features in patients with PD that could influence behavioral aspects.
authors.affiliation: Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy. piacentini@istituto-besta.it
authors.forename: S
authors.initials: S
authors.lastname: Piacentini
authors.forename: R
authors.initials: R
authors.lastname: Versaci
authors.forename: L
authors.initials: L
authors.lastname: Romito
authors.forename: F
authors.initials: F
authors.lastname: Ferré
authors.forename: A
authors.initials: A
authors.lastname: Albanese
mesh_terms: D000368:Aged; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000145:classification* / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D010554:Personality Disorders / Q000145:classification* / Q000175:diagnosis* / Q000209:etiology