title: Oral treatment for Mycobacterium ulcerans infection: results from a pilot study in Benin.
abstract: Mycobacterium ulcerans infection is responsible for severe skin lesions in sub-Saharan Africa. We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oral chemotherapy using rifampicin plus clarithromycin during an 8-week period. The treatment was well tolerated, and all patients were healed by 12 months after initiation of therapy without relapse.
authors.affiliation: Centre de Diagnostic et de Traitement de l'Ulcère de Buruli, Pobè, Bénin.
authors.forename: Annick
authors.initials: A
authors.lastname: Chauty
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Ardant
authors.forename: Laurent
authors.initials: L
authors.lastname: Marsollier
authors.forename: Gerd
authors.initials: G
authors.lastname: Pluschke
authors.forename: Jordi
authors.initials: J
authors.lastname: Landier
authors.forename: Ambroise
authors.initials: A
authors.lastname: Adeye
authors.forename: Aimé
authors.initials: A
authors.lastname: Goundoté
authors.forename: Jane
authors.initials: J
authors.lastname: Cottin
authors.forename: Titilola
authors.initials: T
authors.lastname: Ladikpo
authors.forename: Therese
authors.initials: T
authors.lastname: Ruf
authors.forename: Baohong
authors.initials: B
authors.lastname: Ji
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001541:Benin; D054312:Buruli Ulcer / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000008:administration & dosage / Q000009:adverse effects; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019911:Mycobacterium ulcerans / Q000302:isolation & purification*; D010865:Pilot Projects; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin; D012293:Rifampin