title: Protective effects of green tea on intestinal ischemia-reperfusion injury.
abstract: OBJECTIVE
  The intestinal mucosa is known to be adversely affected by ischemia-reperfusion (I/R). Previously we showed that green tea protects the intestinal mucosa from fasting-induced damage. The aim of this study is to determine whether green tea has any protective role in I/R of the intestine.
  
  
  METHODS
  Three groups of male rats were used in this study. Group I (I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. Group III (control) had sham I/R. After the experiments, the jejunum was removed and the tissues were processed for histopathologic examination and immunohistochemical analysis for cell proliferation markers and antioxidant enzymes.
  
  
  RESULTS
  The intestinal mucosa in group II was preserved compared with that in group I. The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) and cellular antioxidants (superoxide dismutase and catalase) in group II were similar to those in group III and much less than in group I, reflecting the protective effects of green tea in group II animals.
  
  
  CONCLUSIONS
  In this animal model, administration of green tea before inducing I/R protects the intestinal mucosa from injury.
authors.affiliation: Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
authors.forename: S M
authors.initials: SM
authors.lastname: Abdeen
authors.forename: T C
authors.initials: TC
authors.lastname: Mathew
authors.forename: H M
authors.initials: HM
authors.lastname: Dashti
authors.forename: S
authors.initials: S
authors.lastname: Asfar
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers; D002374:Catalase / Q000032:analysis; D049109:Cell Proliferation; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007583:Jejunum / Q000187:drug effects / Q000473:pathology; D008297:Male; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D013662:Tea / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D013662:Tea; D002374:Catalase; D013482:Superoxide Dismutase