title: Underlying conditions in children with invasive pneumococcal disease in the conjugate vaccine era.
abstract: We analyzed characteristics of invasive pneumococcal disease cases occurring in Massachusetts after the introduction and use of conjugate vaccine by underlying risk. Among 578 cases with sufficient information, 16% had high-risk or presumed high-risk conditions (HR/PHR), 3% had asthma, and 80% had no known risk (NKR). The most common HR/PHR conditions were disorders associated with immunosuppression. HR/PHR cases tended to be older and were more likely to be hospitalized than were children with NKR. Children with asthma presented with pneumonia more often than children with NKR.
authors.affiliation: Section of Pediatric Infectious Diseases, Boston University School of Public Health, Boston University Medical Center, Boston, MA, USA.
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Hsu
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Shea
authors.forename: Abbie E
authors.initials: AE
authors.lastname: Stevenson
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Pelton
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008404:Massachusetts / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000473:pathology*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012307:Risk Factors; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate