title: [Different expression of histamine H4 receptor in nasal mucosa in allergic rhinitis patients].
abstract: OBJECTIVE
  To observe expression and distribution of histamine H4 receptor in nasal mucosa in normal people and allergic rhinitis patients,and understand role of histamine H4 receptor in allergic rhinitis.
  
  
  METHODS
  Select normal people and allergic rhinitis patients each 10, take the nasal mucosa, detect expression and distribution of histamine H4 receptor at proteins and transcription level respectively by immunohistochemical method and RT-PCR, and compared.
  
  
  RESULTS
  Histamine H4 receptor at proteins and transcription level were found in normal nasal mucosa (25 509 +/- 6 441, 0.42 +/- 0.08), increased significantly in nasal mucosa of allergic rhinitis patients (49 676 +/- 8 541, 0.69 +/- 0.11, P < 0.05), which in structural cells and immune cells.
  
  
  CONCLUSIONS
  Histamine H4 receptors exist in normal nasal mucosa, its express significantly enhance, flew histamine H4 receptor may be mediated histamine in pathogenesis of allergic rhinitis ,who is one of the ligands of histamine.
authors.affiliation: Department of Otolaryngology, 97th Hospital of PLA, Xuzhou 221004, China. yanzhiq2000@yahoo.com.cn
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yan
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Deben
authors.initials: D
authors.lastname: Li
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Yu
authors.forename: Shenghong
authors.initials: S
authors.lastname: Gao
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Shao
authors.forename: Jinke
authors.initials: J
authors.lastname: Hong
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D011968:Receptors, Histamine / Q000378:metabolism*; D000074040:Receptors, Histamine H4; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: C418607:HRH4 protein, human; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4