title: Adenosine A3 receptor agonist reduces early brain injury in subarachnoid haemorrhage.
abstract: Inflammation plays an important role in the pathogenesis of early brain injury after subarachnoid haemorrhage. Adenosine A3 receptor (A3R) activation produces anti-inflammatory effects. In this study, the effects of a selective A3R agonist, 2-chloro-N⁶-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (CL-IB-MECA), on early brain injury and inflammatory response after subarachnoid haemorrhage were studied. Our results showed that mortality, neurological impairment and brain oedema were significantly attenuated after the administration of CL-IB-MECA. Moreover, treatment with CL-IB-MECA inhibited microglial activation and reduced the expression of proinflammatory cytokines including tumour necrosis factor-α and interleukin-1β. These data suggest that activation of A3R provides a neuroprotective effect against brain injury after subarachnoid haemorrhage, and that these effects may be associated with the anti-inflammatory properties of A3R.
authors.affiliation: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, PR China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Luo
authors.forename: Bin
authors.initials: B
authors.lastname: Yi
authors.forename: Guocai
authors.initials: G
authors.lastname: Tao
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.forename: Weihua
authors.initials: W
authors.lastname: Tang
authors.forename: John H
authors.initials: JH
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Feng
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D058909:Adenosine A3 Receptor Agonists / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000188:drug therapy*
chemical_list: D058909:Adenosine A3 Receptor Agonists; D000241:Adenosine; C090034:2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide