title: hOGG1 Ser326Cys polymorphism and renal cell carcinoma risk in a Chinese population.
abstract: Oxidative DNA damage caused by reactive oxygen species plays an important role in cancer development. Human 8-oxoguanine DNA glycosylase (hOGG1) is involved in base excision repair of 8-oxoguanine from damaged DNA. We hypothesized that variants in the hOGG1 gene are associated with risk of renal cell carcinoma (RCC). In a hospital-based case-control study of 572 RCC patients and 575 cancer-free controls frequency matched by age and sex, we genotyped the functional polymorphism Ser326Cys (rs1052133) and assessed its associations with risk of RCC in a Chinese population. We found that individuals with the Cys allele were associated with an increased risk of RCC (odds ratio [OR] = 1.40, 95% confidence interval [CI] = 1.02-1.90), compared with those with the Ser/Ser genotype, particularly among subgroups of body mass index >24 kg/m(2) (OR = 1.75, 95% CI = 1.12-2.73) and non-smokers (OR = 1.60, 95% CI = 1.07-2.38). Further, the polymorphism was associated with risk of developing localized stage and well-differentiated RCC. Our results suggested that the polymorphism is involved in the etiology of RCC and thus may be a marker for genetic susceptibility to RCC.
authors.affiliation: Department of Urology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Wuxi, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Zhao
authors.forename: Chao
authors.initials: C
authors.lastname: Qin
authors.forename: Fu
authors.initials: F
authors.lastname: Yan
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Cao
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Changjun
authors.initials: C
authors.lastname: Yin
mesh_terms: D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human