title: [Study on the effect of hyperbaric oxygen on apoptosis in the CA1 region of hippocampus following forebrain ischemia reperfusion].
abstract: OBJECTIVE
  To study the mechanism of hyperbaric oxygen (HBO) on the treatment of cerebral ischemia, and to provide theoretical basis for hyperbaric oxygen treatment (HBOT), we examined the effect of 0.15 MPa and 0.25 MPa HBO treatment (60 min/d, for 3 successive days ) on ischemia reperfusion - induced apoptosis in gerbil hippocampus CA1 using TUNEL staining method.
  
  
  RESULTS
  The number of neuronal apoptosis in hippocampus CA1 was significantly decreased in HBOT groups(P < 0.01). Neuronal apoptosis in hippocampus CA1 in 0.25 MPa groups were less than that in 0.15 MPa groups (P < 0.01).
  
  
  CONCLUSIONS
  HBOT is effective in reducing neuronal apoptosis and in protecting neurons from injury of ischemia reperfusion, and 0.25 MPa is an appropriate pressure for HBOT.
authors.affiliation: Naval Medical Research Institute of CPLA, Shanghai 200433.
authors.forename: J G
authors.initials: JG
authors.lastname: Zhou
authors.forename: J C
authors.initials: JC
authors.lastname: Liu
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Fang
mesh_terms: D000818:Animals; D017209:Apoptosis; D002545:Brain Ischemia / Q000473:pathology* / Q000628:therapy; D056547:CA1 Region, Hippocampal / Q000473:pathology*; D005849:Gerbillinae; D006931:Hyperbaric Oxygenation / Q000379:methods*; D009474:Neurons / Q000473:pathology*; D015427:Reperfusion Injury