title: Consuming a small-moderate dose of red wine alone can alter the glucose-insulin relationship.
abstract: The aim in the present study was to assess the effect of small-moderate red wine ingestion on the level of serum insulin and plasma glucose when nutritional status is varied. Twenty nondiabetic males (19-22 years) participated in the study. In the fasting trial, all participants underwent a 6 h fast prior to consuming 4 standard units of red wine (40 g alcohol) or the equivalent amount of placebo as dealcoholized wine (containing <0.5% alcohol, 0% resveratrol) over a 135 min period. Alternatively, in the feeding trial, participants consumed food for 45 min prior to ingesting 4 standard units of red wine (40 g alcohol) or placebo over 135 min. Serum insulin and plasma glucose were assessed at regular 45 min intervals during all trials. The results showed a significant decrease in the level of serum insulin and no significant change in plasma glucose concentration in the fasting trial. Alternatively, a significant alcohol-induced decrease in plasma glucose and no change in serum insulin occurred when red wine alone was consumed after food. It was concluded that red wine can alter the glucose-insulin relationship and ingesting red wine alone (without food) should not be encouraged in nondiabetic individuals.
authors.affiliation: School of Psychological Science, La Trobe University, P.O. Box 199, Bendigo, Victoria 3552, Australia. A.Kokavec@latrobe.edu.au
authors.forename: Anna
authors.initials: A
authors.lastname: Kokavec
authors.forename: Mark A
authors.initials: MA
authors.lastname: Halloran
mesh_terms: D000428:Alcohol Drinking / Q000097:blood*; D000434:Alcoholic Beverages; D001786:Blood Glucose / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage; D005215:Fasting / Q000097:blood; D005502:Food; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D009752:Nutritional Status / Q000502:physiology*; D014920:Wine; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000431:Ethanol