title: Fecal lactoferrin and Clostridium spp. in stools of autistic children.
abstract: Stools from autistic and healthy children were studied for fecal lactoferrin, Clostridium difficile toxins, Clostridium perfringens enterotoxin and cultured for Clostridium spp. Elevated level of FLA was demonstrated in 24.4% stools, all from boys (31.25%). No toxins were detected. Clostridium spp. was isolated with similar frequency from all samples. C. perfringens were isolated significantly often from the autistic stools, intermediate sensitive strains to penicillin 19%, to clindamycin 11.3%, and to metronidazole 7.5% were detected. Further studies on fecal microflora and inflammatory mediators, with larger groups of patients, are required in order to explain their role in neurological deficits.
authors.affiliation: Department of Medical Microbiology, Medical University of Silesia, Katowice, Poland. gmartir@sum.edu.pl
authors.forename: Gayane
authors.initials: G
authors.lastname: Martirosian
authors.forename: Alicja
authors.initials: A
authors.lastname: Ekiel
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Aptekorz
authors.forename: Barbara
authors.initials: B
authors.lastname: Wiechuła
authors.forename: Beata
authors.initials: B
authors.lastname: Kazek
authors.forename: Ewa
authors.initials: E
authors.lastname: Jankowska-Steifer
authors.forename: Jarosław
authors.initials: J
authors.lastname: Jóźwiak
authors.forename: Stanisław
authors.initials: S
authors.lastname: Moskalewski
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001321:Autistic Disorder; D001427:Bacterial Toxins / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003013:Clostridium / Q000302:isolation & purification*; D005243:Feces / Q000737:chemistry* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007781:Lactoferrin / Q000032:analysis*; D008297:Male; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; C490098:LTF protein, human; D007781:Lactoferrin