title: MicroRNAs and other small silencing RNAs in cancer.
abstract: Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognosis, and treatment of cancer. We also describe the possible mechanisms underlying small RNA-mediated transformation and outline the future describing new small RNA families with great potential in cancer biology.
authors.affiliation: Department of Oncology, Lund University, Lund, Sweden.
authors.forename: Carlos
authors.initials: C
authors.lastname: Rovira
authors.forename: Maria C
authors.initials: MC
authors.lastname: Güida
authors.forename: Alfonso
authors.initials: A
authors.lastname: Cayota
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D009369:Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D034622:RNA Interference
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs