title: Antibiotic prophylaxis in the placement of totally implanted central venous access ports.
abstract: BACKGROUND
  Antibiotic prophylaxis during placement of implanted central venous access ports (CVAP) has not been studied. This retrospective review compared the rate of catheter-related infections (CRIs) with and without perioperative antibiotics.
  
  
  METHODS
  This was a single-center study that compared patients treated with and without a single dose of antibiotics during CVAP placement. CRIs were defined as a patient treated with antibiotics for port site induration, positive blood cultures, or suspicion of infection that led to port removal within 30 days of placement.
  
  
  RESULTS
  CVAP were placed in 459 patients, 103 of whom (22.4%) received antibiotic prophylaxis. Surgical technique and patient demographics were similar to those patients not receiving antibiotics (356). All 9 (2%) CRIs occurred in the non-prophylactic antibiotic group (P = .218), with 5 infections resulting in port removal.
  
  
  CONCLUSIONS
  Single-dose perioperative antibiotics may decrease CVAP infection rates and should be studied further in a prospective randomized trial.
authors.affiliation: Department of Surgery, University of Utah, East Salt Lake City, UT 84132, USA. courtney.scaife@hsc.utah.edu
authors.forename: Courtney L
authors.initials: CL
authors.lastname: Scaife
authors.forename: Molly E
authors.initials: ME
authors.lastname: Gross
authors.forename: Mary C
authors.initials: MC
authors.lastname: Mone
authors.forename: Heidi J
authors.initials: HJ
authors.lastname: Hansen
authors.forename: Codi L
authors.initials: CL
authors.lastname: Litz
authors.forename: Edward T
authors.initials: ET
authors.lastname: Nelson
authors.forename: Clayton J
authors.initials: CJ
authors.lastname: Anderson
authors.forename: Graham
authors.initials: G
authors.lastname: Wagner
authors.forename: Ute
authors.initials: U
authors.lastname: Gawlick
authors.forename: Edward W
authors.initials: EW
authors.lastname: Nelson
mesh_terms: D019072:Antibiotic Prophylaxis; D000970:Antineoplastic Agents / Q000008:administration & dosage; D055499:Catheter-Related Infections / Q000517:prevention & control*; D002405:Catheterization, Central Venous; D002408:Catheters, Indwelling; D005260:Female; D006801:Humans; D007601:Jugular Veins; D008297:Male; D008875:Middle Aged; D013350:Subclavian Vein
chemical_list: D000970:Antineoplastic Agents