title: Gerontome: a web-based database server for aging-related genes and analysis pipelines.
abstract: BACKGROUND
  Aging is a complex and challenging phenomenon that requires interdisciplinary efforts to unravel its mystery. Insight into genes relevant to the aging process would offer the chance to delay and avoid some of deteriorative aspects of aging through the use of preventive methods. To assist basic research on aging, a comprehensive database and analysis platform for aging-related genes is required.
  
  
  RESULTS
  We developed a web-based database server, called Gerontome that contains aging-related gene information and user-friendly analysis pipelines. To construct the Gerontome database, we integrated aging-related genes and their annotation data. The aging-related genes were categorized by a set of structural terms from Gene Ontology (GO). Analysis pipelines for promoter analysis and protein-ligand docking were developed. The promoter analysis pipeline allows users to investigate the age-dependent regulation of gene expression. The protein-ligand docking pipeline provides information on the position and orientation of a ligand in an age-related protein surface.
  
  
  CONCLUSIONS
  Gerontome can be accessed through web interfaces for querying and browsing. The server provides comprehensive age-related gene information and analysis pipelines. Gerontome is available free at http://gerontome.kobic.re.kr.
authors.affiliation: Korean BioInformation Center (KOBIC), KRIBB, Daejeon, Korea. kwon@kribb.re.kr
authors.forename: Jekeun
authors.initials: J
authors.lastname: Kwon
authors.forename: Byungwook
authors.initials: B
authors.lastname: Lee
authors.forename: Haeyoung
authors.initials: H
authors.lastname: Chung
mesh_terms: D000375:Aging / Q000235:genetics*; D016208:Databases, Factual; D006801:Humans; D020407:Internet; D012106:Research; D014584:User-Computer Interface