title: Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei).
abstract: An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B(1), showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB(1) and proliferation of a cancer cell line.
authors.affiliation: Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico. gris_wilson@hotmail.com
authors.forename: Griselda
authors.initials: G
authors.lastname: Wilson-Sanchez
authors.forename: Carolina
authors.initials: C
authors.lastname: Moreno-Félix
authors.forename: Carlos
authors.initials: C
authors.lastname: Velazquez
authors.forename: Maribel
authors.initials: M
authors.lastname: Plascencia-Jatomea
authors.forename: Anita
authors.initials: A
authors.lastname: Acosta
authors.forename: Lorena
authors.initials: L
authors.lastname: Machi-Lara
authors.forename: María-Lourdes
authors.initials: ML
authors.lastname: Aldana-Madrid
authors.forename: Josafat-Marina
authors.initials: JM
authors.lastname: Ezquerra-Brauer
authors.forename: Ramón
authors.initials: R
authors.lastname: Robles-Zepeda
authors.forename: Armando
authors.initials: A
authors.lastname: Burgos-Hernandez
mesh_terms: D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors; D000818:Animals; D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D008055:Lipids; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D033561:Penaeidae; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000235:genetics; D014020:Tissue Extracts / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D016587:Antimutagenic Agents; D008055:Lipids; D014020:Tissue Extracts; D016604:Aflatoxin B1