title: Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome.
abstract: OBJECTIVE
  To compare the predictive power of different endothelial progenitor cell (EPC) phenotypic markers for future cardiovascular events.
  
  
  METHODS
  Peripheral blood was collected from 76 consecutive patients with acute coronary syndromes (ACS) who underwent percutaneous coronary intervention in our institute. The various EPC phenotypes of peripheral blood mononuclear cells were CD34+CD133+, CD34+KDR+, and CD 133+KDR+. The outcome endpoint included cardiovascular mortality, recurrent ACS, and hospitalization for decompensated heart failure during a 24-mo follow-up period.
  
  
  RESULTS
  CD34+CD133+ cells (P = 0.034), but not CD34+KDR+ (P = 0.35) or CD 133+KDR+ cells (P = 0.19), were found to predict recurrent ACS. We found no correlation between EPCs measured by any of the three phenotypic combinations of accepted CD markers and the total combination of these separate outcomes.
  
  
  CONCLUSIONS
  The EPC CD34+CD133+ phenotype, but not the CD34+KDR+ or the CD 133+KDR+ phenotypes, is predictive of future adverse cardiovascular outcomes.
authors.affiliation: Shmuel Schwartzenberg, Jacob George, Department of Cardiology, Kaplan Medical Center, affiliated to the Hebrew University, Rehovot 76100, Israel.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Schwartzenberg
authors.forename: Arnon
authors.initials: A
authors.lastname: Afek
authors.forename: Gideon
authors.initials: G
authors.lastname: Charach
authors.forename: Ardon
authors.initials: A
authors.lastname: Rubinstein
authors.forename: Yossi
authors.initials: Y
authors.lastname: Ben-Shoshan
authors.forename: Sarina
authors.initials: S
authors.lastname: Kissil
authors.forename: Sofia
authors.initials: S
authors.lastname: Maisel-Auslender
authors.forename: Gad
authors.initials: G
authors.lastname: Keren
authors.forename: Jacob
authors.initials: J
authors.lastname: George