title: A preclinical in vivo investigation of high-intensity focused ultrasound combined with radiotherapy.
abstract: This study aims to perform an in vivo investigation evaluating the injury to the pancreas and adjacent tissue of swine resulting with high-intensity focused ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by the animal ethics committee at the Peking University First Hospital. A total of 12 domestic swine were divided into four groups: control, HIFU only, RT only and HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the acoustic path of the HIFU beam was assessed based on gross and histologic findings. For the targeted region of the pancreas, the score of the combined group was higher than that of the HIFU group and there was significant difference. For the acoustic path tissue, there was no significant difference except between the control group and the other groups. HIFU combined with RT increased the injury to the targeted pancreas, without increased injury to tissue outside of the targeted region.
authors.affiliation: Department of Radiation Oncology, Peking University First Hospital, Beijing, China.
authors.forename: Chao-Xing
authors.initials: CX
authors.lastname: Liu
authors.forename: Xian-Shu
authors.initials: XS
authors.lastname: Gao
authors.forename: Liu-Lin
authors.initials: LL
authors.lastname: Xiong
authors.forename: Hui-Yu
authors.initials: HY
authors.lastname: Ge
authors.forename: Xin-Yong
authors.initials: XY
authors.lastname: He
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Hong-Zhong
authors.initials: HZ
authors.lastname: Bai
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lin
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.forename: Junichi
authors.initials: J
authors.lastname: Asaumi
mesh_terms: D000818:Animals; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000528:radiation effects*; D010315:Particle Accelerators; D018787:Radiation Oncology; D011897:Random Allocation; D018709:Statistics, Nonparametric; D013552:Swine; D014159:Transducers; D014463:Ultrasonography