title: Antimicrobial resistance: Not community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)! A clinician's guide to community MRSA - its evolving antimicrobial resistance and implications for therapy.
abstract: There is significant diversity in methicillin-resistant Staphylococcus aureus (MRSA) clones arising in the community worldwide, with considerable geographical differences in typical antimicrobial resistance profiles. Many community clones of MRSA have a non-multidrug resistant antimicrobial profile, providing increased options for empirical and directed therapy of infections caused by these strains. However, the recent description of increasing non-β lactam resistance in community clones of MRSA, especially USA300, provides a timely warning for clinicians making decisions about therapy for patients potentially infected with these strains. Continued monitoring of global epidemiology and emerging drug resistance data is critical for the effective management of these infections.
authors.affiliation: Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
authors.forename: Kyra
authors.initials: K
authors.lastname: Chua
authors.forename: Frederic
authors.initials: F
authors.lastname: Laurent
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Coombs
authors.forename: M Lindsay
authors.initials: ML
authors.lastname: Grayson
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Howden
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D058873:Pandemics; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents