title: [Effects of soybean isoflavones on the cell cycles, the cell apoptosis and the proliferation of spleen in radiated mice].
abstract: OBJECTIVE
  To study effect of soybean isoflavones (SI) on spleen in radiated mice.
  
  
  METHODS
  90 male mice were randomly divided into control group, radiated group, radiated plus 0.5% dose SI group. After 2-week feeding, the mice received 4.0 Gy 137Cs gamma-radiation, the cell cycles, cell apoptosis and proliferation on the spleen and the spleen index were observed in radiated after 12 h, 24 h, 1 week and 2 weeks.
  
  
  RESULTS
  After the mice were radiated, the spleen were significantly atrophy, the rate of the cell apoptosis and the cell cycles of G0-G1 phase in splenocytes were significantly increased (P < 0.01), the cell cycles rate of S phase and the proliferation index were significantly decreased in spleen (P < 0.05). Compared with radiated group, the spleen atrophy and the rate of the cell cycles of G0-G1 phase were significantly decreased (P < 0.05), and the cell cycles of G2-M phase and the proliferation index were significantly increased (P < 0.05) in the mice supplied 0.5% soybean isoflavones.
  
  
  CONCLUSIONS
  The soybean isoflavones could significantly increase spleen radioprotective effect in mice.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.forename: Xian-Yuan
authors.initials: XY
authors.lastname: Wang
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Wen-Kao
authors.initials: WK
authors.lastname: Nan
authors.forename: Pei-Bing
authors.initials: PB
authors.lastname: Li
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Wu
authors.forename: Lan-Xing
authors.initials: LX
authors.lastname: Gao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002453:Cell Cycle / Q000187:drug effects* / Q000528:radiation effects; D022082:Cellular Structures; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011839:Radiation, Ionizing; D013025:Glycine max; D013154:Spleen / Q000166:cytology
chemical_list: D007529:Isoflavones