title: Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia.
abstract: The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.02 mg/kg) and compared with dogs injected with saline solution (0.2 mL/kg). Adiponectin and IGF-1 were both decreased in response to endotoxins in the dog. Significant positive correlations were found between adiponectin and IGF-1 (r=0.31; p<0.05). Adiponectin had also a significant negative correlation with CRP (r=-0.39; p<0.05) and Hp (r=-0.27; p<0.05), whereas IGF-1 had significant negative correlation with CRP (r=-0.52; p<0.001). The results obtained in the present study indicate that adiponectin and IGF-1 behave as negative acute phase proteins after acute inflammatory stimulus in dogs.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Murcia University, 30100 Murcia, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.forename: Oya
authors.initials: O
authors.lastname: Eralp
authors.forename: Meric
authors.initials: M
authors.lastname: Kocaturk
authors.forename: Zeki
authors.initials: Z
authors.lastname: Yilmaz
authors.forename: Jose J
authors.initials: JJ
authors.lastname: Ceron
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000097:blood / Q000276:immunology* / Q000382:microbiology; D004285:Dogs; D019446:Endotoxemia / Q000097:blood / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male
chemical_list: D052242:Adiponectin; D006242:Haptoglobins; D008070:Lipopolysaccharides; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein