title: Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment.
abstract: Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a microgravity environment on protein crystallization, especially in the case of this protein.
authors.affiliation: Confocal Science Inc., Japan. tanakah@confsci.co.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Tsurumura
authors.forename: Kosuke
authors.initials: K
authors.lastname: Aritake
authors.forename: Naoki
authors.initials: N
authors.lastname: Furubayashi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Takahashi
authors.forename: Mari
authors.initials: M
authors.lastname: Yamanaka
authors.forename: Erika
authors.initials: E
authors.lastname: Hirota
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sano
authors.forename: Masaru
authors.initials: M
authors.lastname: Sato
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tanaka
authors.forename: Koji
authors.initials: K
authors.lastname: Inaka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Urade
mesh_terms: D003460:Crystallization / Q000379:methods*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000037:antagonists & inhibitors / Q000737:chemistry*; D054834:Lipocalins / Q000037:antagonists & inhibitors / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry; D013026:Space Flight; D014893:Weightlessness; D014961:X-Ray Diffraction
chemical_list: C116322:4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine; D054834:Lipocalins; D010880:Piperidines; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase