title: Domino N-H/C-H bond activation: copper-catalyzed synthesis of nitrogen-bridgehead heterocycles using azoles and 1,4-dihalo-1,3-dienes.
abstract: Copper-catalyzed tandem coupling of 1,4-dihalo-1,3-dienes with azoles via an N-H bond and its adjacent C-H bond activation has been described. The reaction exhibits good regioselectivity when unsymmetrical 1,4-dihalo-1,3-diene is employed. This method provided a novel route to the synthesis of nitrogen-bridgehead azolopyridine derivatives.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liao
authors.forename: Liyun
authors.initials: L
authors.lastname: Zhang
authors.forename: Shutao
authors.initials: S
authors.lastname: Li
authors.forename: Chanjuan
authors.initials: C
authors.lastname: Xi
mesh_terms: D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry*
chemical_list: D001393:Azoles; D006574:Heterocyclic Compounds, 2-Ring; D011090:Polyenes; D003300:Copper