title: [Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease].
abstract: We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver. The diagnosis was suspected when abnormalities in liver function tests were observed and transabdominal ultrasonography and upper gastrointestinal endoscopy showed signs of portal hypertension. The final diagnosis was established by liver biopsy, showing the characteristic alterations in liver architecture. Outcome was favorable after treatment discontinuation, with complete normalization of liver function tests within a year. The present article describes the incidence and the main clinical characteristics of this adverse effect to thiopurines.
authors.affiliation: Servicio de Aparato Digestivo y CIBEREHD, Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: López-Martín
authors.forename: Enrique
authors.initials: E
authors.lastname: de la Fuente-Fernández
authors.forename: Paloma
authors.initials: P
authors.lastname: Corbatón
authors.forename: María Chaparro
authors.initials: MC
authors.lastname: Sánchez
authors.forename: J P
authors.initials: JP
authors.lastname: Gisbert
mesh_terms: D001379:Azathioprine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003424:Crohn Disease / Q000188:drug therapy*; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced; D006975:Hypertension, Portal / Q000139:chemically induced*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine