title: Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression.
abstract: Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2) production were induced in those cells by increasing COX-2 promoter transcription activity, which could be attenuated by a specific p38MAPK inhibitor, suggesting a role for peritoneal fluid in the etiopathogenesis of endometriosis.
authors.affiliation: Department of Chinese Traditional Medicine, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Han
authors.forename: Dongxia
authors.initials: D
authors.lastname: Zai
authors.forename: Zailong
authors.initials: Z
authors.lastname: Cai
authors.forename: Chaoqin
authors.initials: C
authors.lastname: Yu
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000473:pathology / Q000502:physiology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000494:pharmacology; D051546:Cyclooxygenase 2 / Q000235:genetics* / Q000378:metabolism; D004715:Endometriosis / Q000473:pathology*; D004717:Endometrium / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D010532:Peritoneal Diseases / Q000473:pathology*; D011453:Prostaglandins / Q000378:metabolism; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D017077:Culture Media, Conditioned; D011453:Prostaglandins; D051546:Cyclooxygenase 2