title: Decreased small dense LDL levels in Gilbert's syndrome.
abstract: OBJECTIVE
  To investigate the role of small dense low density lipoprotein cholesterol (sd-LDL-C) in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).
  
  
  METHODS
  sd-LDL-C, ox-LDL, and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (n=42) and compared to healthy controls (n=52).
  
  
  RESULTS
  Age, gender and body mass index (BMI) distributions were similar between the two groups. sd-LDL-C, ox-LDL and hs-CRP levels were lower in GS than the healthy controls (p<0.001, p<0.001 and p=0.001, respectively). Unconjugated bilirubin was negatively correlated with sd-LDL-C, ox-LDL and hs-CRP (r=-0.594, p<0.001; r=-0.249, p=0.016 and r=-0.373, p<0.001 respectively). In addition, sd-LDL-C was positively correlated with ox-LDL (r=0.307, p=0.003).
  
  
  CONCLUSIONS
  The findings of this preliminary study suggest that reduced sd-LDL-C, ox-LDL and hs-CRP levels may have a role in preventing atherosclerosis in subjects with GS.
authors.affiliation: Department of Medical Biochemistry, Gulhane School of Medicine, Ankara, Turkey. serkantapan7@yahoo.com
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Nuri
authors.initials: N
authors.lastname: Karadurmus
authors.forename: Teoman
authors.initials: T
authors.lastname: Dogru
authors.forename: Cemal Nuri
authors.initials: CN
authors.lastname: Ercin
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Cumhur
authors.initials: C
authors.lastname: Bilgi
authors.forename: Ismail
authors.initials: I
authors.lastname: Kurt
authors.forename: Mehmet Kemal
authors.initials: MK
authors.lastname: Erbil
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D001663:Bilirubin / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005878:Gilbert Disease / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein; D001663:Bilirubin