title: Three novel NEIL1 promoter polymorphisms in gastric cancer patients.
abstract: OBJECTIVE
  To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients.
  
  
  METHODS
  The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses.
  
  
  RESULTS
  Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients.
  
  
  CONCLUSIONS
  Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.
authors.affiliation: Masanori Goto, Kazuya Shinmura, Hong Tao, Haruhiko Sugimura, First Department of Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, Shizuoka 431-3192, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Goto
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shinmura
authors.forename: Hong
authors.initials: H
authors.lastname: Tao
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sugimura