title: [Expressions of Cyr61 and WISP-3 in non-small cell lung cancer and its clinical significance].
abstract: BACKGROUND
  Cysteine-rich protein 61 (Cyr61) plays a role as a tumor suppressor in non-small cell lung cancer (NSCLC). Cyr61 and WISP-3 have a very significant sequence homology, belonging to the same CCN gene family. The aim of this study is to investigate the expressions of Cyr61 and WISP-3 in NSCLC, and explore the relationship between their expressions and tumor's clinicopathological characteristics.
  
  
  METHODS
  The expressions of Cyr61 and WISP-3 were detected in 54 cases with primary NSCLC and their corresponding normal lung tissues in control group by immunohistochemical staining (SP), and the clinical data were analyzed.
  
  
  RESULTS
  Down-regulation of Cyr61 and up-regulation of WISP-3 were both found in lung cancer tissue compared with the corresponding normal lung tissue (both P < 0.001); The expression of Cyr61 was negatively correlated with the expression of WISP-3 (r=-0.395, P=0.003); Cyr61 expression levels was closely correlated with tumor grade, tumor type, clinical stage, family history, smoking and metastasis (P < 0.05). Also, WISP-3 was closely correlated with tumor grade, clinical stage and age (P < 0.05).
  
  
  CONCLUSIONS
  The expressions of Cyr61 and/or WISP-3 may be important biological markers in reflecting the progression, biological behaviors, metastatic potential and prognosis of NSCLC.
authors.affiliation: Department of Thoracic Surgery, People's Hospital of Hanchuan, Hanchuan 431600, China.
authors.forename: Jianfa
authors.initials: J
authors.lastname: LV
authors.forename: Youcheng
authors.initials: Y
authors.lastname: ZOU
authors.forename: Chunwei
authors.initials: C
authors.lastname: ZHANG
authors.forename: Zhifu
authors.initials: Z
authors.lastname: MAO
mesh_terms: D000328:Adult; D000368:Aged; D055511:CCN Intercellular Signaling Proteins; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D055515:Cysteine-Rich Protein 61 / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D055511:CCN Intercellular Signaling Proteins; C501848:CCN1 protein, human; C400081:CCN6 protein, human; D055515:Cysteine-Rich Protein 61; D018969:Insulin-Like Growth Factor Binding Proteins