title: A Mangifera indica L. extract could be used to treat neuropathic pain and implication of mangiferin.
abstract: It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic pain. Vimang is an aqueous extract of Mangifera indica L. traditionally used in Cuba for its analgesic, anti-inflammatory, antioxidant and immunomodulatory properties. Several formulations are available, and also for mangiferin, its major component. Preclinical studies demonstrated that these products prevented tumor necrosis factor α -induced IκB degradation and the binding of nuclear factor κB to DNA, which induces the transcription of genes implicated in the expression of some mediators and enzymes involved in inflammation, pain, oxidative stress and synaptic plasticity. In this paper we propose its potential utility in the neuropathic pain treatment. This hypothesis is supported in the cumulus of preclinical and clinical evidence around the extract and mangiferin, its major component, and speculates about the possible mechanism of action according to recent advances in the physiopathology of neuropathic pain.
authors.affiliation: Laboratorio de Farmacología Molecular del Centro de Investigación y Desarrollo de Medicamentos, Ave. 26 No. 1605, Nuevo Vedado, Havana, Cuba. beatriz.garrido@infomed.sld.cu
authors.forename: Bárbara B
authors.initials: BB
authors.lastname: Garrido-Suárez
authors.forename: Gabino
authors.initials: G
authors.lastname: Garrido
authors.forename: Rene
authors.initials: R
authors.lastname: Delgado
authors.forename: Fe
authors.initials: F
authors.lastname: Bosch
authors.forename: María
authors.initials: M
authors.lastname: del C Rabí
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D031022:Mangifera / Q000737:chemistry*; D016328:NF-kappa B / Q000378:metabolism; D009437:Neuralgia / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D044004:Xanthones / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D018836:Inflammation Mediators; C501277:Mangifera indica extract; D016328:NF-kappa B; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D044004:Xanthones; C013592:mangiferin