title: Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis.
abstract: Interleukin 17 (IL-17) is a Th17 cytokine associated with inflammation, autoimmunity, and defense against some bacteria; it has been implicated in many chronic autoimmune diseases including psoriasis, multiple sclerosis, and systemic sclerosis. However, whether IL-17 plays a role in the pathogenesis of ankylosing spondylitis (AS) remains unclear. To analyze the content of IL-17 and IL-23 in the serum from patients with AS compared with health control subject, 50 patients with AS and 43 healthy volunteers were recruited. Serum IL-17 levels were examined by enzyme linked immunosorbent assay (ELISA). Statistic analyses were performed by SPSS 13.0. Results show that the serum IL-17 and IL-23 levels were significantly elevated in AS patients as compared with normal controls. Nevertheless, no associations of serum IL-17 and IL-23 levels with clinical and laboratory parameters were found; no significant difference regarding serum IL-17 and IL-23 levels was found between less active AS and more active AS. However, there was a strong positive association between the serum levels of IL-17 and IL-23 in the AS patients. Our results indicate increased serum IL-17 and IL-23 levels in AS patients, suggesting that this two cytokine may play critical roles in the pathogenesis of AS. Therefore, further studies are required to confirm this preliminary data.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Mei
authors.forename: Faming
authors.initials: F
authors.lastname: Pan
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Rui
authors.initials: R
authors.lastname: Ge
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Duan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zeng
authors.forename: Fangfang
authors.initials: F
authors.lastname: Liao
authors.forename: Guo
authors.initials: G
authors.lastname: Xia
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Shengqian
authors.initials: S
authors.lastname: Xu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Dongqing
authors.initials: D
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000097:blood*
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23