title: Kaposi's sarcoma in two primary liver allograft recipients occurring under FK506 immunosuppression.
abstract: Of 1463 liver allograft recipients receiving the combination of FK506 and steroids as their primary immunosuppressive regimen, 2 patients developed Kaposi's sarcoma. Although previously described as a complication of organ transplantation, this is the first case report of Kaposi's sarcoma occurring in association with the macrolide immunosuppressive agent FK506. A discussion of the clinical presentation and course of Kaposi's sarcoma in these 2 patients, as well as a review of the past literature on Kaposi's sarcoma in organ transplant recipients, emphasizes the therapeutic difficulties encountered. Kaposi's sarcoma is also compared to lymphoproliferative disorders, another well-recognized complication of immunosuppression, highlighting the differences between these two entities.
authors.affiliation: Pittsburgh Transplant Institute, Departments of Surgery, University of Pittsburgh Health and Science Center, Pittsburgh, PA.
authors.forename: Zaklyah
authors.initials: Z
authors.lastname: Kadry
authors.forename: Oscar
authors.initials: O
authors.lastname: Bronsther
authors.forename: David H
authors.initials: DH
authors.lastname: Van Thiel
authors.forename: Parmjeet
authors.initials: P
authors.lastname: Randhawa
authors.forename: John J
authors.initials: JJ
authors.lastname: Fung
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Starzl