title: Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae.
abstract: To elucidate mechanisms of arsenic toxicity and biological defense mechanisms against arsenic, we searched for genes that, when overexpressed, conferred arsenite resistance on yeast. Employing a Saccharomyces cerevisiae open reading frame (ORF) library, four genes associated with arsenite resistance, FAP7, MIG3, TMA19, and YLR392c, were identified.
authors.affiliation: Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Toomi
authors.initials: T
authors.lastname: Yano
authors.forename: Junxuan
authors.initials: J
authors.lastname: Zhu
authors.forename: Gi-Wook
authors.initials: GW
authors.lastname: Hwang
authors.forename: Akira
authors.initials: A
authors.lastname: Naganuma
mesh_terms: D018053:Arsenites / Q000633:toxicity*; D025141:Drug Resistance, Fungal / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects*; D015723:Gene Library; D016366:Open Reading Frames / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D015854:Up-Regulation; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D018053:Arsenites; D029701:Saccharomyces cerevisiae Proteins; D014874:Water Pollutants, Chemical; C015001:arsenite