title: Shedding pattern and serological profile of porcine circovirus type 2 infection in cesarean-derived, colostrum-deprived and farm-raised pigs.
abstract: Six 5-week-old porcine circovirus type 2 (PCV2)-free, cesarean-derived, colostrums-deprived (CDCD) pigs were inoculated intranasally with 10(6) TCID(50) of PCV2. Four CDCD pigs were untreated cohabitants. Forty farm-raised pigs from two PCV2-contaminated herds were randomly selected for PCV2 trace investigations. Blood, nasal, oropharyngeal and fecal samples were collected from all tested pigs weekly. The PCV2 DNA shed at 6-11 and 7-12 weeks of age for PCV2-inoculated pigs and cohabitants, respectively. All the CDCD pigs exhibited seroconversion after PCV2 exposure. In the farm-raised animals, PCV2 shed at 9-15 weeks of age and seroconversion started at 11 weeks of age. Collectively, the pigs had a prolonged PCV2 shedding period following viral exposure, and growing pigs were the source of horizontal PCV2 transmission in PCV2-infected herds.
authors.affiliation: Department of Veterinary Medicine, National Pingtung University of Science and Technology, Neipu, Pingtung 912, Taiwan R.O.C. mtchiou@mail.npust.edu.tw
authors.forename: Ming-Tang
authors.initials: MT
authors.lastname: Chiou
authors.forename: Cheng-Yao
authors.initials: CY
authors.lastname: Yang
authors.forename: Tsung-Chou
authors.initials: TC
authors.lastname: Chang
authors.forename: Chimin
authors.initials: C
authors.lastname: Chen
authors.forename: Chuen-Fu
authors.initials: CF
authors.lastname: Lin
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Ye
mesh_terms: D000375:Aging; D000818:Animals; D002585:Cesarean Section / Q000662:veterinary*; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D017925:Circovirus; D003126:Colostrum; D005243:Feces / Q000821:virology; D009093:Mucus / Q000821:virology; D009960:Oropharynx / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000821:virology*; D017201:Virus Shedding / Q000502:physiology*