title: [A study of effects of impaired glucose tolerance on ventricular remodeling].
abstract: OBJECTIVE
  To evaluate the effects of impaired glucose tolerance (IGT) on ventricular remodeling.
  
  
  METHODS
  Parameters of every subject including left ventricular mass (LVM), left ventricular mass index (LVMI), E/A ratio, 75 g oral glucose tolerance test (OGTT), ambulatory blood pressure monitoring (ABPM) data including 24-hour mean systolic blood pressure (mSBP) and 24-hour mean diastolic blood pressure (mDBP) were collected. Then the relationship of IGT and myocardial remodeling related parameters were analyzed.
  
  
  RESULTS
  The rate of diastolic dysfunction was higher in the IGT combined with hypertensive group (74%) compared with the hypertensive group (39%) (χ(2) = 6.5, P < 0.05). The rate of diastolic dysfunction was higher in the IGT group (34%) compared with the normal group (10%) (χ(2) = 5.2, P < 0.05). The rate of Left Ventricular Hypertrophy (LVH) in the IGT combined with hypertensive group (24%) was higher than the other three groups (Hypertension group 7%, IGT group 0, Normal group 0) (χ(2) = 4.56 1, P < 0.05), and there was no significance between the rest three groups (P > 0.05). Stepwise multiple regression showed age and 2 Hours' Postprandial Blood Glucose were independent risk factors of E/A ratio.
  
  
  CONCLUSIONS
  These results suggested that IGT is a possible contributor to left ventricular hypertrophy and diastolic dysfunction, and is one of the histopathology of left ventricular remodeling.
authors.affiliation: Department of Cardiology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China.
authors.forename: Jian-xi
authors.initials: JX
authors.lastname: Tang
authors.forename: Xiu-fang
authors.initials: XF
authors.lastname: Lin
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Xie
authors.forename: Zhi-juan
authors.initials: ZJ
authors.lastname: Zhou
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.forename: Lan
authors.initials: L
authors.lastname: Yao
authors.forename: Yu-sheng
authors.initials: YS
authors.lastname: Zheng
mesh_terms: D000328:Adult; D005260:Female; D018149:Glucose Intolerance; D044882:Glucose Metabolism Disorders / Q000378:metabolism* / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020257:Ventricular Remodeling