title: Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus.
abstract: A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) or saline in lipid and protein oxidation levels and superoxide dismutase (SOD) and catalase (CAT) activities in rat prefrontal cortex and hippocampus. Acute and chronic treatments with imipramine and harmine reduced lipid and protein oxidation, compared to control group in prefrontal cortex and hippocampus. The SOD and CAT activities increased with acute and chronic treatments with imipramine and harmine, compared to control group in prefrontal cortex and hippocampus. In conclusion, our results indicate positive effects of imipramine antidepressant and β-carboline harmine of oxidative stress parameters, increasing SOD and CAT activities and decreasing lipid and protein oxidation.
authors.affiliation: Laboratório de Neurociências, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC Brazil.
authors.forename: Gislaine Z
authors.initials: GZ
authors.lastname: Réus
authors.forename: Roberto B
authors.initials: RB
authors.lastname: Stringari
authors.forename: Bruna
authors.initials: B
authors.lastname: de Souza
authors.forename: Fabrícia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: Jaime E
authors.initials: JE
authors.lastname: Hallak
authors.forename: Antônio W
authors.initials: AW
authors.lastname: Zuardi
authors.forename: José A
authors.initials: JA
authors.lastname: Crippa
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D003863:Depression / Q000188:drug therapy; D006247:Harmine / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D006247:Harmine; D002374:Catalase; D013482:Superoxide Dismutase; D007099:Imipramine