title: Microencapsulation of okadaic acid as a tool for studying the accumulation of DSP toxins in mussels.
abstract: The possibility and effectiveness of microencapsulation of okadaic acid (OA) in gelatin-acacia microcapsules has been studied. The encapsulation efficiency was higher than 33%. The microcapsules were shown to be very stable, not leaching more than 9% of the encapsulated OA in a 20-h period. OA from the microcapsules was absorbed by the mussels very efficiently, accumulating--after 3 days of feeding and one of depuration--65% of the OA in microcapsules and 22% of the total OA used at the beginning of the microencapsulation process. These efficiencies and the possibility of encapsulating single DSP toxins and derivatives constitute a valuable tool for the study of the accumulation and biotransformation of DSP toxins in bivalves.
authors.affiliation: Centro de Investigacións Mariñas (CIMA), Pedras de Corón, s/n. Apdo. 13, 36620 Vilanova de Arousa, Pontevedra, Spain.
authors.forename: Araceli E
authors.initials: AE
authors.lastname: Rossignoli
authors.forename: David
authors.initials: D
authors.lastname: Fernández
authors.forename: Carmen P
authors.initials: CP
authors.lastname: Acosta
authors.forename: Juan
authors.initials: J
authors.lastname: Blanco
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000378:metabolism*; D004141:Dinoflagellida / Q000472:pathogenicity; D004339:Drug Compounding; D008387:Marine Toxins / Q000378:metabolism*; D019319:Okadaic Acid / Q000737:chemistry / Q000378:metabolism*; D057096:Shellfish Poisoning; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D008387:Marine Toxins; D019319:Okadaic Acid