title: [Kidney, adipose tissue, adipocytes--what's new?].
abstract: Increased evidence suggests that obesity-related glomerulopathy and chronic kidney diseases should be identified as isolated complications of obesity. It is questioned if the numerous adipose tissue productions could play a role in the initiation/maintenance of such kidney diseases. This review will provide a sum-up of recent advances on fat cell metabolism and adipose tissue physiology. The adipose tissue behaves as an endocrine organ with multiple activities. It is secreting hormones (leptin, adiponectin, apelin) and numerous factors with autocrine, paracrine and systemic effects. These secretions are coming from adipocytes themselves or from cells present in the stroma-vascular fraction of the adipose tissue. When expanding, the adipose tissue of the obese is infiltrated by immune cells such as macrophages and lymphocytes; the role of which is not fully clarified. An attempt will be done to delineate if alterations of lipid storage/fatty acid release or of the secretion potencies of adipose tissue could contribute to kidney lipotoxicity and other chronic kidney diseases described in the obese.
authors.affiliation: Équipe 1, unité Inserm 1048, institut des maladies cardiovasculaires et métaboliques, BP 84225, 31432 Toulouse cedex 4, France. max.lafontan@inserm.fr
authors.forename: Max
authors.initials: M
authors.lastname: Lafontan
mesh_terms: D017667:Adipocytes / Q000276:immunology / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D052436:Adipose Tissue, White / Q000276:immunology / Q000378:metabolism*; D000073861:Apelin; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D016207:Cytokines / Q000378:metabolism; D019317:Evidence-Based Medicine; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000276:immunology / Q000378:metabolism*
chemical_list: C115436:APLN protein, human; D052242:Adiponectin; D000073861:Apelin; D015415:Biomarkers; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin