title: Could helical tomotherapy do whole brain radiotherapy and radiosurgery?
abstract: Whole brain radiotherapy (WBRT) remains the standard management of breast cancer patients with brain metastases, allowing for symptomatic improvement and good local control in most patients. However, its results remain suboptimal in terms of both efficacy and toxicity. In highly selected breast cancer patients, stereotaxic radiotherapy demonstrates a very good local control with a low toxicity. With the purpose of improving the efficacy/toxicity ratio, we report the association of integrated boost with WBRT in a breast cancer patient with brain metastases. Two and a half years after completion of helical tomotherapy (HT), the patient experienced clinical and radiological complete remission of her brain disease. No delayed toxicity occurred and the patient kept her hair without need of radiosurgical procedure. The HT provided a high dosimetric homogeneity, delivering integrated radiation boosts, and avoiding critical structures involved in long-term neurological toxicity. Further assessment is required and recruitment of breast cancer patients into clinical trials is encouraged.
authors.affiliation: Youlia M Kirova, Cyrus Chargari, Sofia Zefkili, François Campana, Department of Radiation Oncology, Institut Curie, 75005 Paris, France.
authors.forename: Youlia M
authors.initials: YM
authors.lastname: Kirova
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
authors.forename: Sofia
authors.initials: S
authors.lastname: Zefkili
authors.forename: François
authors.initials: F
authors.lastname: Campana