title: Candidate gene association studies.
abstract: Candidate gene association studies aim to establish or characterise association between the genetic -variation occurring within a specific gene or locus and a phenotype. If the phenotype is quantitative, then the effect size is often measured as the difference between the genotype specific means or a per allele effect. When the phenotype is binary and the disease is either present or absent, the effect is summarised as a genotype specific risk or relative risk. This chapter focuses on methodology employed when a single or small number of genetic loci are being investigated for an association with a specific phenotype.
authors.affiliation: Health Services Research, School of Health and Related Research, University of Sheffield, Sheffield, UK.
authors.forename: M Dawn
authors.initials: MD
authors.lastname: Teare
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies / Q000379:methods*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D015201:Meta-Analysis as Topic; D010024:Osteoporosis / Q000235:genetics; D019655:Quantitative Trait, Heritable; D009626:Terminology as Topic