title: Alzheimer's disease gene signature says: beware of brain viral infections.
abstract: BACKGROUND
  Recent findings from a genome wide association investigation in a large cohort of patients with Alzheimer's disease (AD) and non demented controls (CTR) showed that a limited set of genes was in a strong association (p > l0-5) with the disease.
  
  
  OBJECTIVE
  In this report we suggest that the polymorphism association in 8 of these genes is consistent with a non conventional interpretation of AD etiology.Nectin-2 (NC-2), apolipoprotein E (APOE), glycoprotein carcinoembryonic antigen related cell adhesion molecule- 16 (CEACAM-16), B-cell lymphoma-3 (Bcl-3), translocase of outer mitochondrial membrane 40 homolog (T0MM-40), complement receptor-1 (CR-l), APOJ or clusterin and C-type lectin domain A family-16 member (CLEC-16A) result in a genetic signature that might affect individual brain susceptibility to infection by herpes virus family during aging, leading to neuronal loss, inflammation and amyloid deposition.
  
  
  CONCLUSIONS
  We hypothesized that such genetic trait may predispose to AD via complex and diverse mechanisms each contributing to an increase of individual susceptibility to brain viral infections.
authors.affiliation: Department of Experimental Pathology, School of Medicine, University of Bologna Italy. federico.licastro@unibo.it.
authors.forename: Elisa
authors.initials: E
authors.lastname: Porcellini
authors.forename: Ilaria
authors.initials: I
authors.lastname: Carbone
authors.forename: Manuela
authors.initials: M
authors.lastname: Ianni
authors.forename: Federico
authors.initials: F
authors.lastname: Licastro