title: Current academic clinical trials in ovarian cancer: Gynecologic Cancer Intergroup and US National Cancer Institute Clinical Trials Planning Meeting, May 2009.
abstract: OBJECTIVE
  To review the current status of large phase academic clinical trials for women with ovarian cancer, address cross-cutting issues, and identify promising areas for future collaboration.
  
  
  METHODS
  In May 2009, the Gynecologic Cancer Intergroup, which represents 19 Cooperative Groups conducting trials for women with gynecologic cancer, and the US National Cancer Institute convened a Clinical Trials Planning Meeting.
  
  
  RESULTS
  The topics covered included the impact of new developments in cancer biology upon molecular targets and novel agents, pharmacogenomics, advances in imaging, the potential benefit of diet and exercise to reduce the risk of recurrence, academic partnership with industry, statistical considerations for phases 2 and 3 trials, trial end points, and symptom benefit and health-related quality-of-life issues. The clinical trials discussed spanned the spectrum of ovarian cancer from initial diagnosis, staging, and cytoreductive surgery to consolidation chemotherapy, and treatment of recurrent disease.
  
  
  CONCLUSIONS
  Ongoing and effective collaboration with industry, government, and patients aims to ensure that the most important scientific questions can be answered rapidly. We encourage women with ovarian cancer and their oncologists to consider participation in the academic clinical trials conducted by the member groups of the Gynecologic Cancer Intergroup.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7436, USA. tt6m@nih.gov
authors.forename: Edward L
authors.initials: EL
authors.lastname: Trimble
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Birrer
authors.forename: William J
authors.initials: WJ
authors.lastname: Hoskins
authors.forename: Christian
authors.initials: C
authors.lastname: Marth
authors.forename: Ray
authors.initials: R
authors.lastname: Petryshyn
authors.forename: Michael
authors.initials: M
authors.lastname: Quinn
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Thomas
authors.forename: Henry C
authors.initials: HC
authors.lastname: Kitchener
authors.forename: Carol
authors.initials: C
authors.lastname: Aghajanian
authors.forename: David S
authors.initials: DS
authors.lastname: Alberts
authors.forename: Deborah
authors.initials: D
authors.lastname: Armstrong
authors.forename: Jubilee
authors.initials: J
authors.lastname: Brown
authors.forename: Robert L
authors.initials: RL
authors.lastname: Coleman
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Colombo
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Eisenhauer
authors.forename: Michael
authors.initials: M
authors.lastname: Friedlander
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Sally
authors.initials: S
authors.lastname: Hunsberger
authors.forename: Stan
authors.initials: S
authors.lastname: Kaye
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ledermann
authors.forename: Susanna
authors.initials: S
authors.lastname: Lee
authors.forename: Katherine
authors.initials: K
authors.lastname: Look
authors.forename: Robert
authors.initials: R
authors.lastname: Mannel
authors.forename: Iain A
authors.initials: IA
authors.lastname: McNeish
authors.forename: Lori
authors.initials: L
authors.lastname: Minasian
authors.forename: Amit
authors.initials: A
authors.lastname: Oza
authors.forename: Jim
authors.initials: J
authors.lastname: Paul
authors.forename: Andres
authors.initials: A
authors.lastname: Poveda
authors.forename: Eric
authors.initials: E
authors.lastname: Pujade-Lauraine
authors.forename: Mason
authors.initials: M
authors.lastname: Schoenfeldt
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Swart
authors.forename: Vivian
authors.initials: V
authors.lastname: von Gruenigen
authors.forename: Lari
authors.initials: L
authors.lastname: Wenzel
mesh_terms: D000046:Academic Medical Centers; D002986:Clinical Trials as Topic; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007391:International Cooperation; D054547:National Cancer Institute (U.S.); D014481:United States