title: Tuberculosis treatment in a refugee and migrant population: 20 years of experience on the Thai-Burmese border.
abstract: METHODS
  Although tuberculosis (TB) is a curable disease, it remains a major global health problem and an important cause of morbidity and mortality among vulnerable populations, including refugees and migrants.
  
  
  OBJECTIVE
  To describe results and experiences over 20 years at a TB programme in refugee camps on the Thai-Burmese border in Tak Province, Thailand, and to identify risk factors associated with adverse outcomes (e.g., default, failure, death).
  
  
  METHODS
  Retrospective review of routine records of 2425 patients admitted for TB treatment in the Mae La TB programme between May 1987 and December 2005.
  
  
  RESULTS
  TB cases notified among refugees decreased over 20 years. Among patients treated with a first-, second- or third-line regimen, 77.5% had a successful outcome, 13.5% defaulted, 7.6% died and 1.3% failed treatment. Multivariate analysis for new cases showed higher likelihood of adverse outcomes for patients who were Burmese migrants or Thai villagers, male, aged >15 years or with smear-negative pulmonary TB.
  
  
  CONCLUSIONS
  These findings suggest that treatment outcomes depend on the programme's capacity to respond to specific patients' constraints. High-risk groups, such as migrant populations, need a patient-centred approach, and specific, innovative strategies have to be developed based on the needs of the most vulnerable and marginalised populations.
authors.affiliation: Médecins Sans Frontières, Paris, France. andrea.minetti@epicentre.msf.org
authors.forename: A
authors.initials: A
authors.lastname: Minetti
authors.forename: O
authors.initials: O
authors.lastname: Camelique
authors.forename: K
authors.initials: K
authors.lastname: Hsa Thaw
authors.forename: S
authors.initials: S
authors.lastname: Thi
authors.forename: W
authors.initials: W
authors.lastname: Swaddiwudhipong
authors.forename: C
authors.initials: C
authors.lastname: Hewison
authors.forename: L
authors.initials: L
authors.lastname: Pinoges
authors.forename: M
authors.initials: M
authors.lastname: Bonnet
authors.forename: P J
authors.initials: PJ
authors.lastname: Guerin
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D002052:Myanmar / Q000208:ethnology; D018802:Patient-Centered Care / Q000379:methods; D012036:Refugees / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D013183:Sputum / Q000382:microbiology; D013785:Thailand / Q000453:epidemiology; D014171:Transients and Migrants / Q000706:statistics & numerical data; D017211:Treatment Failure; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology / Q000208:ethnology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000453:epidemiology / Q000208:ethnology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents