title: Regional cerebral blood flow changes in patients with idiopathic REM sleep behavior disorder.
abstract: BACKGROUND
  Recent studies have shown an association between rapid eye movement sleep behavior disorder (RBD) and neurodegenerative disorders, especially alpha-synucleinopathies.
  
  
  OBJECTIVE
  We investigated regional cerebral blood flow (rCBF) changes using single photon emission computed tomography (SPECT) in patients with idiopathic RBD (iRBD), to determine functional brain alterations associated with the disorder.
  
  
  METHODS
  The SPECT data of 24 patients with iRBD were compared with those of 18 age-matched normal controls using statistical parametric mapping 2.
  
  
  RESULTS
  We found decreased rCBF in the parietooccipital lobe (precuneus), limbic lobe, and cerebellar hemispheres in patients with iRBD, which is commonly seen in patients with Lewy body disease (Parkinson's disease and dementia with Lewy bodies) or multiple system atrophy.
  
  
  CONCLUSIONS
  Our SPECT study suggests that iRBD can be a presymptomatic stage of alpha-synucleinopathies.
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan. h-hanyu@tokyo-med.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Hanyu
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: H
authors.initials: H
authors.lastname: Kanetaka
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Sasai
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
mesh_terms: D000368:Aged; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D015897:Comorbidity / Q000639:trends; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020187:REM Sleep Behavior Disorder / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D011877:Radionuclide Imaging; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein