title: New imidazoline/α(2)-adrenoceptors affecting compounds-4(5)-(2-aminoethyl)imidazoline (dihydrohistamine) derivatives. Synthesis and receptor affinity studies.
abstract: Compilation of agmatine structure and imidazoline moiety leads to a new group of imidazoline/α(2)-adrenoceptor ligands, 4(5)-(2-aminoethyl)imidazoline derivatives. In this study the exploration of previously unknown 4(5)-(2-aminoethyl)imidazolines including the analogues of reported imidazoline and α(2)-aderenoceptors ligands: clonidine, rilmenidine, idazoxan, efaroxan, antazoline, tracizoline is described. The synthesis of a variety of novel 4(5)-(2-aminoethyl)imidazolines and their I(1), I(2), α(2)-adrenoceptors affinities are reported.
authors.affiliation: Department of Pharmaceutical Technology and Biochemistry, The Faculty of Chemistry, Gdańsk University of Technology, Narutowicza St 11/12, 80-952 Gdańsk, Poland.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Treder
authors.forename: Ryszard
authors.initials: R
authors.lastname: Andruszkiewicz
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Zgoda
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Walkowiak
authors.forename: Celeste
authors.initials: C
authors.lastname: Ford
authors.forename: Alan L
authors.initials: AL
authors.lastname: Hudson
mesh_terms: D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects*
chemical_list: D007093:Imidazoles; D018341:Receptors, Adrenergic, alpha-2