title: Potential of casein kinase I in digestive cancer screening.
abstract: Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential therapeutic targets in treatment of digestive cancers. In this review, we summarize up to date what is known about this family of kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in digestive cancers and their potential for cancer screening and therapy.
authors.affiliation: Cristina Modak, Jianyuan Chai, Department Research (09-151), VA Long Beach Healthcare System, Long Beach, 90822 and the University of California, Irvine, CA 92697, United States.
authors.forename: Cristina
authors.initials: C
authors.lastname: Modak
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Chai