title: [Risks of cyclosporine therapy in paediatric age].
abstract: BACKGROUND
  Cyclosporine has been found to be effective and safe in many inflammatory skin disorders such as psoriasis and atopic dermatitis (AD), in adults and in children. Its use in paediatrics is still under scope. We present three patients who started cyclosporine but stopped due to complications. It is our aim to warn about potential side effects of cyclosporine and recommend cautious utilization.
  
  
  METHODS
  Two children, aged 4 and 13 years, with AD and one child, aged 2 years, with erythrodermic psoriasis, were treated with oral cyclosporine.
  
  
  METHODS
  developed secondary impetigo on the 6th day of treatment. Started topical corticosteroids and topical calcineurin inhibitors afterwards, with no relapses.
  
  
  METHODS
  developed herpetic infection, hepatic and renal impairment (eventual drug interaction) on the 4th day of treatment. THIRD CASE: Psoriasis and impetigo, treated with flucloxacillin, gentamicin. Generalized angioedema and urticariform lesions after 6 days of cyclosporine. Beta lactam hypersensitivity reaction under study. Eventual cyclosporine toxicity to consider.
  
  
  CONCLUSIONS
  The data on cyclosporine use in children is still scarce. Use should be limited to cases with precise indication, after considering risks and benefits.
authors.affiliation: Serviços de Imunoalergologia, Unidade de Infecciologia, Hospital Dona Estefânia, Lisboa.
authors.forename: João
authors.initials: J
authors.lastname: Antunes
authors.forename: Catarina
authors.initials: C
authors.lastname: Gouveia
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Brito
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D016572:Cyclosporine / Q000009:adverse effects*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D011565:Psoriasis / Q000188:drug therapy*; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine