title: Overexpression of transglutaminase in the Drosophila wing imaginal disc induced an extra wing crossvein phenotype.
abstract: To determine the roles of Drosophila transglutaminase-A (dTG-A), we examined a phenotype induced through ectopic expression of dTG-A. Overexpression of dTG-A in the wing imaginal disc induced an extra wing crossvein phenotype. This phenotype was suppressed by crossing with epidermal growth factor receptor (Egfr) signaling pathway mutant flies. These results indicate that this phenotype, induced by dTG-A, is related to enhancement of the Egfr signaling pathway.
authors.affiliation: Department of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ichikawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Yamada
authors.forename: Harunobu
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Umehara
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Koji
authors.initials: K
authors.lastname: Ikura
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000033:anatomy & histology* / Q000201:enzymology* / Q000235:genetics; D015870:Gene Expression; D010641:Phenotype; D011503:Transglutaminases / Q000235:genetics*; D014921:Wings, Animal / Q000033:anatomy & histology* / Q000201:enzymology*
chemical_list: D011503:Transglutaminases