title: [Interest of immunohistochemistry for the diagnosis of benign hepatocellular tumors].
abstract: In this review, we focus on the interest of immunohistochemistry first, to differentiate the two types of benign hepatocellular nodules: focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) and second, to recognize the different subtypes of HCA: HNF1α inactivated HCA, β-catenin activated HCA and inflammatory HCA. This pathomolecular classication followed the study of genotype/phenotype correlations which led to the identification of immunohistochemical data characteristic of each subgroup. Immunohistochemical characteristics described on resected specimen are suitable on biopies of these tumors, facilitating their diagnosis and therefore allowing a better management of the patients.
authors.affiliation: Hôpital Pellegrin, CHU de Bordeaux, France. paulette.bioulac-sage@chu-bordeaux.fr
authors.forename: Paulette
authors.initials: P
authors.lastname: Bioulac-Sage
authors.forename: Charles
authors.initials: C
authors.lastname: Balabaud
authors.forename: Jessica
authors.initials: J
authors.lastname: Zucman-Rossi
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D003937:Diagnosis, Differential; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D005974:Glutamate-Ammonia Ligase / Q000032:analysis / Q000502:physiology; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000032:analysis / Q000235:genetics / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D008113:Liver Neoplasms / Q000737:chemistry / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D051176:beta Catenin / Q000032:analysis / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D051176:beta Catenin; D005974:Glutamate-Ammonia Ligase