title: Association analysis of Toll-like receptor 7 gene polymorphisms and Behçet's disease in Japanese patients.
abstract: Action of Toll-like receptors (TLRs) is deeply associated with defense mechanisms of the innate and adaptive immune responses to microbial pathogens. There have been reports of genetic polymorphisms within the TLR7 gene being closely related to a variety of inflammatory and infectious diseases. Behçet's disease (BD) is an autoinflammatory disease, and the pathogenesis has yet to be fully discovered. We investigated whether polymorphisms of Toll-like receptor 7 (TLR7) are associated with BD by analyzing the frequency of eight single nucleotide polymorphisms (SNPs) within 200 Japanese BD patients and 102 randomized controls. We genotyped nine SNPs in the TLR7 gene and assessed the allele/genotype diversity between cases and controls for all SNPs. In all eight SNPs, statistically significant differences were not observed between cases and controls.
authors.affiliation: Department of Ophthalmology and Visual Science, Yokohama City University, Graduate School of Medicine, Kanagawa, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sada
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Katsuyama
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nomura
authors.forename: Riyo
authors.initials: R
authors.lastname: Uemoto
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Nishide
authors.forename: Eiichi
authors.initials: E
authors.lastname: Okada
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics; D001528:Behcet Syndrome / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D056660:Hereditary Autoinflammatory Diseases / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007564:Japan; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D051199:Toll-Like Receptor 7 / Q000235:genetics*
chemical_list: C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7