title: IFITM6 expression is increased in macrophages of tumor-bearing mice.
abstract: The family of interferon-induced transmembrane protein (IFITM) genes consists of IFITM1, 2, 3, 5, and 6. They encode cell surface proteins that modulate cell-cell adhesion and cell differentiation. In a previous study, we showed that IFITM1 is involved in the immune escape and metastasis of gastric cancer cells. In this study, we determined the difference in expression of IFITM family genes in tumor-bearing mice. IFITM1 and 6 were found to be significantly increased. IFITM6 gene expression was increased only in the spleen of tumor-bearing mice but not in the bone marrow, lymph node, or thymus. IFITM6 expression was induced in various macrophages, including splenic, thioglycollate-elicited, and bone marrow-derived macrophages, but not in T cells. Lipopolysaccharides (LPS) also increased IFITM6 expression 24 h after administration, and Toll-like receptor 1, 2, 3, 4, and 9 agonists stimulated IFITM6 expression. These findings imply that the increase in IFITM6 expression may be involved in macrophage functions of tumor-bearing mice.
authors.affiliation: Department of Biological Science, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
authors.forename: Jeong Hye
authors.initials: JH
authors.lastname: Han
authors.forename: Sunyi
authors.initials: S
authors.lastname: Lee
authors.forename: Yun Sun
authors.initials: YS
authors.lastname: Park
authors.forename: Jeong Su
authors.initials: JS
authors.lastname: Park
authors.forename: Kun-Yong
authors.initials: KY
authors.lastname: Kim
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lim
authors.forename: Ki Sook
authors.initials: KS
authors.lastname: Oh
authors.forename: Young
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D005810:Multigene Family; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D014185:Transplantation, Isogeneic; D015854:Up-Regulation / Q000235:genetics
chemical_list: C558000:IFITM6 protein, mouse; D008562:Membrane Glycoproteins; D008565:Membrane Proteins