title: [Relationship between cyclooxysenase 2 and serious hepatitis].
abstract: OBJECTIVE
  To study the cytokines regulated downstream effecter cyclooxygenase (COX-2's) function in the progression of serious hepatitis.
  
  
  METHODS
  Samples from 75 patients with hepatitis B virus (HBV)-associated serious liver disease with well-characterised clincal profiles and 30 HBV-infected patients were assessed by ELISA.
  
  
  RESULTS
  Compared with the general HBV-infected patients, serum TXB2 and 6-keto-PG1α level were uniformly elevated in all serious hepatitis patients (acute serious hepatitis patients vs general HBV-infected patients (P < 0.001); sub-acute serious hepatitis patients vs general HBV-infected patients (P < 0.01); chronic serious hepatitis patients vs general HBV-infected patients (P < 0.001). But there were no significant difference of these cytokines levels among the different types of serious hepatitis patients (P > 0.05).
  
  
  CONCLUSIONS
  In conclusion, product of COX-2 metabolism TXB2 and 6-keto-PGF1α were associated with the clinical progression of serious hepatitis; especially TXB2/6-keto-PGF1α ratio is an effective biological marker for prognosis and diagnosis for serious hepatitis.
authors.affiliation: Department of Gasteroenterology, Yanan University, Xi'an, China.
authors.forename: Ma
authors.initials: M
authors.lastname: Dong-rui
authors.forename: Yuan
authors.initials: Y
authors.lastname: Dong-hong
authors.forename: Xie
authors.initials: X
authors.lastname: Hua-hong
authors.forename: Liu
authors.initials: L
authors.lastname: Jie
mesh_terms: D015415:Biomarkers / Q000097:blood*; D051546:Cyclooxygenase 2 / Q000097:blood*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006505:Hepatitis / Q000175:diagnosis; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000378:metabolism; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D004279:DNA, Viral; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human