title: [Advanced breast cancer in a patient achieving long-term SD after letrozole administration for liver metastasis developing during anastrozole therapy].
abstract: We report a 69-year-old woman with breast cancer who was effectively treated with letrozole as a second-line therapy after becoming resistant to anastrozole. Her chief complaint at presentation was back pain. Physical examination and imaging studies showed a left breast tumor with skin invasion, multiple intramammary lesions, enlarged left axillary lymph node, and multiple bone metastases. Needle biopsy revealed invasive ductal carcinoma(scirrhous carcinoma)that was ER+/PgR+/ HER2-. The administration of anastrozole and bisphosphonate for 13 months resulted in a 33% reduction of the longest diameters of the breast tumors, but a liver metastasis developed. The treatment was changed to letrozole administration from January 2007.T he optimal effect of letrozole as determined by measurement on CT images was long-term SD maintained for about 13 months. No significant side effects were observed, and the QOL was favorable.
authors.affiliation: Dept. of Surgery, Takatsuki Red Cross Hospital.
authors.forename: You
authors.initials: Y
authors.lastname: Ichinose
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Akihisa
authors.initials: A
authors.lastname: Fujimoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Uchida
authors.forename: Tetsu
authors.initials: T
authors.lastname: Sasaoki
authors.forename: Kenzo
authors.initials: K
authors.lastname: Goto
mesh_terms: D000368:Aged; D000077384:Anastrozole; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D000077289:Letrozole; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D009570:Nitriles / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D000077289:Letrozole