title: Slow-release formulation of a new biological pesticide, pyoluteorin, with mesoporous silica.
abstract: A slow-release formula of potential biological pesticide Pyoluteorin (Plt) was prepared by using nanophase material of silicon dioxide loading drugs. The final experimental formula was m(Plt:Brij56:TMOS:HCl(aq)) = 0.04:1.4:2:1, synthesized by a highly ordered monolith (HOM) method. This formula can continuously release 85.13 ± 2.03 % of Plt within 28 days. A characterization study showed the formula formed a well-ordered mesoporous structure, with a surface area of 822 m(2) g(-1), with a measured mesoporous volume of 0.41 cm(3) g(-1) and a narrow distribution for the pore size centered at 2.4 nm. A bioactivity experiment showed it authentically prolonged the antifungal effects. This study is the first to report mesoporous formulations for biological pesticides and indicates a potentially interesting drug carrier. The association of a nanostructured silica to the molecular state of the drug holds great interests for field applications as it overcomes the rapid loss of biological function during drug utilities.
authors.affiliation: Key Laboratory of Microbial Metabolism, Ministry of Education, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Xu
authors.forename: Xuehong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000737:chemistry; D010575:Pesticides / Q000493:pharmacokinetics*; D010636:Phenols / Q000493:pharmacokinetics*; D016062:Porosity; D011758:Pyrroles / Q000493:pharmacokinetics*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D010575:Pesticides; D010636:Phenols; D011758:Pyrroles; C095503:pyoluteorin; D012822:Silicon Dioxide