title: Oxaliplatin-Related Ocular Toxicity.
abstract: We report the case of a 52-year-old woman with advanced colorectal cancer who was treated with oxaliplatin on a FOLFOX schedule. After 3 cycles of chemotherapy, she started to complain of visual loss, altered color vision and neurological symptoms. Due to the suspicion of ocular and neurological toxicity, antineoplastic treatment was stopped. Her visual field showed a concentric bilateral scotoma and the electrooculogram test revealed severe impairment of the retinal pigment epithelium. Visual acuity, color vision and visual field recovered completely 8 months later, although electrooculogram remained abnormal. Ocular toxicity has been reported as an infrequent adverse event of oxaliplatin. Findings in this case indicate toxicity of this chemotherapeutic agent on the retinal pigment epithelium, which has not been reported before. This damage could be permanent, and it thus differs from previously described oxaliplatin-induced ocular toxicities, which are usually transient and reversible. With increasing use of oxaliplatin as first-line treatment in advanced colorectal cancer, we have to be aware of this possible toxicity.
authors.affiliation: Ophthalmology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Mesquida
authors.forename: Bernardo
authors.initials: B
authors.lastname: Sanchez-Dalmau
authors.forename: Santiago
authors.initials: S
authors.lastname: Ortiz-Perez
authors.forename: Laura
authors.initials: L
authors.lastname: Pelegrín
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Molina-Fernandez
authors.forename: Marc
authors.initials: M
authors.lastname: Figueras-Roca
authors.forename: Ricardo
authors.initials: R
authors.lastname: Casaroli-Marano
authors.forename: Alfredo
authors.initials: A
authors.lastname: Adán