title: Plasma deposited stability enhancement coating for amorphous ketoprofen.
abstract: A hydrophobic fluorocarbon coating deposited onto amorphous ketoprofen via pulsed plasma-enhanced chemical vapor deposition (PPECVD) significantly prolonged the onset of recrystallization compared to uncoated drug. Rapid freezing (RF) employed to produce amorphous ketoprofen was followed by PPECVD of perfluorohexane. The effect of coating thickness on the recrystallization and dissolution behavior of ketoprofen was investigated. Samples were stored in open containers at 40°C and 75% relative humidity, and the onset of recrystallization was monitored by DSC. An increase in coating thickness provided enhanced stability against recrystallization for up to 6 months at accelerated storage conditions (longest time of observation) when compared to three days for uncoated ketoprofen. Results from XPS analysis demonstrated that an increase in coating thickness was associated with improved surface coverage thus enabling superior protection. Dissolution testing showed that at least 80% of ketoprofen was released in buffer pH 6.8 from all coated samples. Overall, an increase in coating thickness resulted in a more complete drug release due to decreased adhesion of the coating to the substrate.
authors.affiliation: Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712, USA. sbosselmann@mail.utexas.edu
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bosselmann
authors.forename: Donald E
authors.initials: DE
authors.lastname: Owens
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Kennedy
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Herpin
authors.forename: Robert O
authors.initials: RO
authors.lastname: Williams
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D007660:Ketoprofen / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen