title: [The relationship between the lung function and the level of TNF-α in serum in COPD department of respiratory].
abstract: OBJECTIVE
  To explore the relationship between the lung function and the level of TNF-α in serum in COPD.
  
  
  METHODS
  60 patients with COPD and 35 normal subjects were involved in the study. The serum TNF-α level was measured by ELISA and the lung function were determined.
  
  
  RESULTS
  The level of TNF-α were significantly different in acute and stable COPD group, control group (P < 0.01). The levels of FEVI, FVC, FEVI/FVC and MMEF in acute and stable COPD group were significantly lower than those control group (P < 0.01). The levels of TNF-α was negatively correlated with FEVI, FVC, FEVI/FVC and MMEF (r = -0.586, -0.714, -0.527, -0.639, P < 0.05).
  
  
  CONCLUSIONS
  The TNF-α are involved in airway inflammation and the pathogenetic process of COPD, and may influence the lung function.
authors.affiliation: Department of Respiratory of the Second People's Hospital of Ba-Nan Area, Chongqin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yong-hong
authors.forename: Wang
authors.initials: W
authors.lastname: Dao-xin
mesh_terms: D000368:Aged; D006140:Guaifenesin / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D012129:Respiratory Function Tests; D012143:Respiratory Physiological Phenomena / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000097:blood*; D014797:Vital Capacity / Q000276:immunology
chemical_list: D014409:Tumor Necrosis Factor-alpha; D006140:Guaifenesin