title: [Effects of Honeysuckle flower and Scutellaria Baicalensis Georgi on constraction and electric activity of rabbit small intestine smooth muscle].
abstract: OBJECTIVE
  To investigate the effect of Honeysuckle flower (HF) and Scutellaria Baicalensis Georgi (SBG) on contraction and electric activity of small intestine smooth muscle in rabbit and the underlying mechanisms.
  
  
  METHODS
  Using organ bath technique to observe the effect of HF and SBG on contractive and electric activity of small intestine smooth muscle in rabbit.
  
  
  RESULTS
  HF and SBG significantly decreased the amplitude, frequency and area under the curve of contractive, as well as electric activity in a dose-depended manner. IC50 of the contractive amplitude was 6.30 g/L and 1.56 g/L by Logit Loglinear analysis. The inhibitive effect of HF and SBG on contractive activity could be partly decreased by beta-receptor blocker Propranolol, NO synthase inhibitor L-NAME, and K+ channel blocker Glibenclamide. Also HF and SBG inhibited acetylcholine-induced both intracellular and extracellular calcium-depended contraction significantly.
  
  
  CONCLUSIONS
  HF and SBG obviously inhibit the contractive and electric activity of small intestine smooth muscle of rabbit. The mechanisms are related to several pathways.
authors.affiliation: Department of Physiology, the College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Shi-jun
authors.initials: SJ
authors.lastname: Song
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Yuan
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D003864:Depression, Chemical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D035264:Flowers / Q000737:chemistry; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000502:physiology; D031239:Lonicera / Q000737:chemistry*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology*; D011817:Rabbits; D031364:Scutellaria baicalensis / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal