title: Different profiles of Alzheimer's disease cerebrospinal fluid biomarkers in controls and subjects with subjective memory complaints.
abstract: Cerebrospinal fluid (CSF) biomarkers, such as Aβ(42), total-tau and phosphorylated-tau(181) reflect neuropathological changes of Alzheimer's disease (AD). We studied these biomarkers in 24 controls and 19 subjects with subjective memory complaints, and we distinguished different CSF profiles: normal (group 1, 55.8%), only pathologic Aβ(42) (group 2, 27.9%), pathologic Aβ(42) plus pathologic total-tau and/or phosphorylated-tau(181) (group 3, 7%), and only pathologic total-tau and phosphorylated-tau(181) (group 4, 9.3%). Group 2 could represent an earlier phase of preclinical AD than group 3, and group 4 an unknown etiology.
authors.affiliation: Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), C/Villarroel, 170, 08036, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Antonell
authors.forename: Juan
authors.initials: J
authors.lastname: Fortea
authors.forename: Lorena
authors.initials: L
authors.lastname: Rami
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bosch
authors.forename: Mircea
authors.initials: M
authors.lastname: Balasa
authors.forename: Raquel
authors.initials: R
authors.lastname: Sánchez-Valle
authors.forename: Alex
authors.initials: A
authors.lastname: Iranzo
authors.forename: José Luis
authors.initials: JL
authors.lastname: Molinuevo
authors.forename: Albert
authors.initials: A
authors.lastname: Lladó
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins