title: [The crucial role of the proto-oncogene c-mos in regulation of oocyte maturation].
abstract: Meiosis arrest before fertilization is a common and unique feature of oogenesis in many animal species. On account of the unclear biological significance of meiosis arrest at various stages and for different durations in different animal species, this process and its regulation are the subject of many scientific studies. Studies on the development of ovarian teratomas proved to be helpful in defining the role of particular genes and biochemical cycles in control of the cell cycle in animals. These benign tumors are a valuable source of information on oocyte maturation. The c-mos proto-oncogene, which is specifically expressed in female and male germ cells, plays a crucial role in control of meiotic cell division in mammals. Its product--Mos protein kinase--acting through mitogen-activated protein kinases (MAPKs) regulates critical cellular functions required for homeostasis and decides about cell survival or apoptosis. The MAPK kinase kinase--MAPK kinase--MAPK (MKKK-MKK-MAPK) phosphorelay system, in view of its role in cells, seems to be the ideal target for therapeutic intervention in cancer and other diseases. The recent research on human oocytes suggests that the basic mechanisms regulating various stages of oocyte maturation are similar to those described in animals.
authors.affiliation: I Katedra i Klinika Ginekologii i Położnictwa Akademii Medycznej we Wrocławiu, 50-369 Wrocław. irejoz@interia.pl
authors.forename: Irena
authors.initials: I
authors.lastname: Jałocha
authors.forename: Marian Stanisław
authors.initials: MS
authors.lastname: Gabryś
authors.forename: Jarosław
authors.initials: J
authors.lastname: Bal
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D016200:Maturation-Promoting Factor / Q000378:metabolism; D008540:Meiosis / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology; D000090063:Proto-Oncogene Mas; D017231:Proto-Oncogene Proteins c-mos / Q000378:metabolism*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D017231:Proto-Oncogene Proteins c-mos; D016200:Maturation-Promoting Factor; D020928:Mitogen-Activated Protein Kinases