title: Antibacterial and anti-inflammatory activities of 4-hydroxycordoin: potential therapeutic benefits.
abstract: 4-Hydroxycordoin (1), a natural isopentenyloxychalcone, is a plant secondary metabolite that is relatively rare. Since there are very few reports about the biological activities of 1, its potential benefits for periodontal disease were investigated. A marked and dose-dependent antibacterial activity of 1 was observed against the three major periodontal pathogens, Porphyromonas gingivalis, Fusobacterium nucleatum, and Prevotella intermedia. Moreover, compound 1 showed an antiadhesion effect, since it inhibited attachment of P. gingivalis to oral epithelial cells. Finally, using a macrophage model, the ability of 1 to inhibit the secretion of inflammatory mediators induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide was demonstrated. The anti-inflammatory effect observed was associated with reduced activation of the nuclear factor-κB (NF-κB) p65 and activator protein-1 (AP-1) pathways.
authors.affiliation: Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 Rue de la Terrasse, Québec City, QC, Canada, G1V 0A6.
authors.forename: Mark
authors.initials: M
authors.lastname: Feldman
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tanabe
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Daniel
authors.initials: D
authors.lastname: Grenier
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015232:Dinoprostone / Q000032:analysis / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008954:Models, Biological; D015394:Molecular Structure; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000382:microbiology; D051818:Replication Protein C / Q000187:drug effects; D051996:Transcription Factor RelA / Q000187:drug effects
chemical_list: C558040:4-hydroxycordoin; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D047188:Chalcones; D008070:Lipopolysaccharides; D051996:Transcription Factor RelA; D051818:Replication Protein C; D015232:Dinoprostone