title: Magnetic resonance findings in the pregeniculate visual pathways in Leber hereditary optic neuropathy.
abstract: Two relatives, a 61-year-old man and the 21-year-old grandson of his sister, suffered from bilateral visual loss and were diagnosed with Leber hereditary optic neuropathy. In both cases, the diagnosis was molecularly confirmed with the 11778 mitochondrial mutation. MRI showed increased T2 signal not only in the optic nerves and chiasm but also in the optic tracts, extending to the lateral geniculate bodies. To our knowledge, the latter finding has not been described previously.
authors.affiliation: Department of Neuroradiology, Center for Medical Imaging and Physiology, Skåne University Hospital, and Department of Diagnostic Radiology, Lund University, Lund, Sweden. danielle.van_westen@med.lu.se
authors.forename: Danielle
authors.initials: D
authors.lastname: van Westen
authors.forename: Björn
authors.initials: B
authors.lastname: Hammar
authors.forename: Gunnel
authors.initials: G
authors.lastname: Bynke
mesh_terms: D001339:Autonomic Fibers, Preganglionic / Q000473:pathology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D029242:Optic Atrophy, Hereditary, Leber / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D014795:Visual Pathways / Q000473:pathology*; D055815:Young Adult