title: Modulation of cytokine secretion and oxidative metabolism of innate immune effectors by Rhodococcus biosurfactant.
abstract: The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells.
authors.affiliation: Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm.
authors.forename: V A
authors.initials: VA
authors.lastname: Chereshnev
authors.forename: S V
authors.initials: SV
authors.lastname: Gein
authors.forename: T A
authors.initials: TA
authors.lastname: Baeva
authors.forename: T V
authors.initials: TV
authors.lastname: Galkina
authors.forename: M S
authors.initials: MS
authors.lastname: Kuyukina
authors.forename: I B
authors.initials: IB
authors.lastname: Ivshina
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D007113:Immunity, Innate; D010084:Oxidation-Reduction; D012240:Rhodococcus / Q000502:physiology*; D013501:Surface-Active Agents / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D013501:Surface-Active Agents