title: Modelling lung cancer due to radon and smoking in WISMUT miners: preliminary results.
abstract: A mechanistic two-stage carcinogenesis model has been applied to model lung-cancer mortality in the largest uranium-miner cohort available. Models with and without smoking action both fit the data well. As smoking information is largely missing from the cohort data, a method has been devised to project this information from a case-control study onto the cohort. Model calculations using 256 projections show that the method works well. Preliminary results show that if an explicit smoking action is absent in the model, this is compensated by the values of the baseline parameters. This indicates that in earlier studies performed without smoking information, the results obtained for the radiation parameters are still valid. More importantly, the inclusion of smoking-related parameters shows that these mainly influence the later stages of lung-cancer development.
authors.affiliation: Laboratory for Radiation Research, National Institute for Public Health and the Environment (RIVM), PO Box 1, NL-3720 MA Bilthoven, The Netherlands. harmen.bijwaard@rivm.nl
authors.forename: Harmen
authors.initials: H
authors.lastname: Bijwaard
authors.forename: Fieke
authors.initials: F
authors.lastname: Dekkers
authors.forename: Teun
authors.initials: T
authors.lastname: van Dillen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005859:Germany, East / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D008906:Mining / Q000706:statistics & numerical data*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D015995:Prevalence; D016016:Proportional Hazards Models; D011886:Radon / Q000032:analysis*; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking; D055815:Young Adult
chemical_list: D011886:Radon