title: Discovery of a novel biomarker in the urine in women with endometriosis.
abstract: OBJECTIVE
  To investigate whether proteins secreted in urine differ between women with and without endometriosis.
  
  
  METHODS
  Laboratory study using human urine.
  
  
  METHODS
  University-based laboratory.
  
  
  METHODS
  Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage.
  
  
  METHODS
  Urine collection from women with and without endometriosis.
  
  
  METHODS
  Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis.
  
  
  RESULTS
  On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis.
  
  
  CONCLUSIONS
  Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.
authors.affiliation: Department of Obstetrics and Gynaecology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, Sydney, New South Wales, Australia. ntokushige@med.usyd.edu.au
authors.forename: Natsuko
authors.initials: N
authors.lastname: Tokushige
authors.forename: Robert
authors.initials: R
authors.lastname: Markham
authors.forename: Ben
authors.initials: B
authors.lastname: Crossett
authors.forename: Seong B
authors.initials: SB
authors.lastname: Ahn
authors.forename: Vidya L
authors.initials: VL
authors.lastname: Nelaturi
authors.forename: Alamgir
authors.initials: A
authors.lastname: Khan
authors.forename: Ian S
authors.initials: IS
authors.lastname: Fraser
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine*; D015153:Blotting, Western; D004715:Endometriosis / Q000175:diagnosis* / Q000652:urine*; D005260:Female; D006801:Humans; D053539:Keratin-19 / Q000652:urine*; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D015854:Up-Regulation / Q000502:physiology
chemical_list: D015415:Biomarkers; D053539:Keratin-19