title: [Application study of periarticular multimodal drug injection in total knee arthroplasty].
abstract: OBJECTIVE
  To investigate and compare the analgesic effect of a periarticular multimodal drug injection and patient-controlled epidural analgesia (PCEA) in total knee arthroplasty (TKA).
  
  
  METHODS
  Thirty-six patients undergoing unilateral TKA were randomly divided into two groups (A and B). Group A received a periarticular injection of ropivacaine, morphine and epinephrine at operation and Group B did not. All patients received postoperative patient-controlled epidural analgesia (PCEA). Preoperative baseline data, surgery-related conditions, postoperative VAS (visual analog score), range of motion (ROM), time of opening PCEA, drug dosage in PCEA and side effects were recorded respectively.
  
  
  RESULTS
  At 6, 12 hour VAS in Group A was lower than Group B (P < 0.05). The time of opening PCEA in Group A was longer than Group B (P < 0.05). The drug dosage in PCEA in Group A was less than Group B (P < 0.05). There was no difference of surgical conditions, ROM, 24/48 hour VAS and side effects between two groups (P > 0.05).
  
  
  CONCLUSIONS
  Periarticular drug injection during TKA can relieve pain early after TKA, prolong the time of opening PCEA and reduce the drug dosage in PCEA.
authors.affiliation: Department of Orthopedics, Peking Union Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. qww007@sohu.com
authors.forename: Wen-wei
authors.initials: WW
authors.lastname: Qian
authors.forename: Xi-sheng
authors.initials: XS
authors.lastname: Weng
authors.forename: Qi
authors.initials: Q
authors.lastname: Fei
authors.forename: Ye
authors.initials: Y
authors.lastname: Li
authors.forename: Ji-liang
authors.initials: JL
authors.lastname: Zhai
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Bian
mesh_terms: D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local