title: The Bulgarian vaccine Crimean-Congo haemorrhagic fever virus strain.
abstract: The Crimean-Congo haemorrhagic fever virus (CCHFV) is a 3-segmented RNA virus, which causes disease with a high fatality rate in humans. An inactivated suckling mouse brain-derived vaccine is used in Bulgaria for protection against CCHF. Strain V42/81 is currently used for the vaccine preparation. As the M-RNA segment plays a major role in the immune response, the full-length M segment sequence of the V42/81 strain was characterized. A great genetic diversity was observed among CCHFV strains. In order to gain an insight into the topology of the strain in the CCHFV phylogenetic trees, the full-length S and partial L segments were additionally sequenced and analyzed.
authors.affiliation: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
authors.forename: Anna
authors.initials: A
authors.lastname: Papa
authors.forename: Evangelia
authors.initials: E
authors.lastname: Papadimitriou
authors.forename: Iva
authors.initials: I
authors.lastname: Christova
mesh_terms: D002031:Bulgaria; D016000:Cluster Analysis; D014644:Genetic Variation; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000235:genetics* / Q000276:immunology; D006479:Hemorrhagic Fever, Crimean / Q000517:prevention & control*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D015164:Vaccines, Inactivated / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics* / Q000276:immunology
chemical_list: D012367:RNA, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines