title: Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae?
abstract: Imipenem and meropenem Vitek 2 MICs were evaluated for a panel of 104 Enterobacteriaceae for identification of carbapenemase producers. The sensitivity and specificity values for the new CLSI interpretative criteria (CLSI document M100-S20-U, 2010) were 98% and 83% for imipenem and 76% and 83% for meropenem, respectively. We propose an algorithm that is highly sensitive (98%) and specific (94%) for carbapenemase screening based on the combined use of imipenem and meropenem MICs.
authors.affiliation: Servicio Antimicrobianos, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Carlos G. Malbrán, Ministerio de Salud y Ambiente de la Nación, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Fernando
authors.initials: F
authors.lastname: Pasteran
authors.forename: Celeste
authors.initials: C
authors.lastname: Lucero
authors.forename: Rolando
authors.initials: R
authors.lastname: Soloaga
authors.forename: Melina
authors.initials: M
authors.lastname: Rapoport
authors.forename: Alejandra
authors.initials: A
authors.lastname: Corso
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000032:analysis*; D004755:Enterobacteriaceae / Q000201:enzymology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests / Q000379:methods; D012680:Sensitivity and Specificity; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; C063912:carbapenemase; D000077731:Meropenem