title: Effect of the fixator stiffness on the young regenerate bone after bone transport: computational approach.
abstract: Bone transport is a well accepted technique for the treatment of large bony defects. This process is mechanically driven, where mechanical forces play a central role in the development of tissues within the distracted gap. One of the most important mechanical factors that conditions the success of bone regeneration during distraction osteogenesis is the fixator stiffness not only during the distraction phase but also during the consolidation phase. Therefore, the aim of the present work is to evaluate the effect of the stiffness of the fixator device on the interfragmentary movements and the tissue outcome during the consolidation phase. A previous differentiation model (Claes and Heigele, 1999) is extended in order to take into account the different behaviors of the tissues in tension and compression. The numerical results that were computed concur with experimental findings; a stiff fixator promotes bone formation while the excessive motion induced by extremely flexible fixators is adverse for bony bridging. Experimental interfragmentary movement is similar to that computed numerically.
authors.affiliation: Department of Mechanical Engineering, University of Seville, 41092 Seville, Spain. erreina@us.es
authors.forename: E
authors.initials: E
authors.lastname: Reina-Romo
authors.forename: M J
authors.initials: MJ
authors.lastname: Gómez-Benito
authors.forename: J
authors.initials: J
authors.lastname: Domínguez
authors.forename: F
authors.initials: F
authors.lastname: Niemeyer
authors.forename: T
authors.initials: T
authors.lastname: Wehner
authors.forename: U
authors.initials: U
authors.lastname: Simon
authors.forename: L E
authors.initials: LE
authors.lastname: Claes
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D001842:Bone and Bones / Q000473:pathology*; D019245:Compressive Strength; D016267:External Fixators; D020342:Finite Element Analysis; D005592:Fracture Fixation; D006801:Humans; D010012:Osteogenesis; D019857:Osteogenesis, Distraction; D012756:Sheep; D012984:Software; D013314:Stress, Mechanical; D013718:Tensile Strength; D014018:Tissue Distribution