title: Regional and subcellular localization of cycloprolylglycine in rat brain.
abstract: HPLC analysis showed that endogenous cyclopeptide cycloprolylglycine exhibiting mnemotropic and anxiolytic properties is nonuniformly distributed between brain structures in rats: its contents in the whole brain, cortex, and hippocampus were 29.2±1.6, 38.9±8.0, 126.4±32.4 nmol/g, respectively. Cycloprolylglycine distribution between subcellular fractions of brain neurons is also nonuniform: 60% cyclopeptide appeared in the nuclear fraction.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S S
authors.initials: SS
authors.lastname: Boiko
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: M V
authors.initials: MV
authors.lastname: Vichuzhanin
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D008297:Male; D010456:Peptides, Cyclic / Q000378:metabolism*; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism*
chemical_list: D010456:Peptides, Cyclic; C062238:cyclo(prolylglycyl)