title: The role of PML in the nervous system.
abstract: The promyeloctic leukemia protein PML is a tumor suppressor that was originally identified due to its involvement in the (15;17) translocation of acute promyelocytic leukemia. While the majority of early research has focused upon the role of PML in the pathogenesis of leukemia, more recent evidence has identified important roles for PML in tissues outside the hemopoietic system, including the central nervous system (CNS). Here, we review recent literature on the role of PML in the CNS, with particular focus on the processes of neurodevelopment and neurodegeneration, and propose new lines of investigation.
authors.affiliation: Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. p.salomoni@ucl.ac.uk
authors.forename: Paolo
authors.initials: P
authors.lastname: Salomoni
authors.forename: Joanne
authors.initials: J
authors.lastname: Betts-Henderson
mesh_terms: D000818:Animals; D006801:Humans; D009420:Nervous System / Q000166:cytology / Q000378:metabolism*; D058953:Neural Stem Cells / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins