title: Impact of early rise of intraocular pressure on visual outcome following diabetic vitrectomy.
abstract: OBJECTIVE
  The objective was to study the incidence and risk factors for an early rise in intraocular pressure (IOP) following pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR) and to correlate its impact on visual outcome.
  
  
  METHODS
  This was a longitudinal prospective study. IOP and best corrected visual acuity (BCVA) for 73 cases of PDR (52 males and 21 females) who underwent PPV were recorded at day 1, week 1, and months 1, 3, and 6. Risk factors for the early IOP rise, defined as IOP ≥ 30 mmHg at day 1, were evaluated using cross-tabulation and the t-test.
  
  
  RESULTS
  Mean IOP at day 1 was 21.8 ± 9.8 mmHg with 15 cases (20.5%) having an early rise in IOP. Risk factors for the early IOP rise included intraoperative fibrovascular frond removal (P = 0.003), lens removal (P = 0.043), and intraoperative vitreous bleed (P = 0.008). The early rise in IOP was also associated with consistently raised IOP (P = 0.02), defined as IOP > 21 mmHg during first three consecutive follow-up visits. Further, difference in BCVA at 6 months among the two groups, i.e., with and without an early IOP rise was statistically significant (3.11 ± 1.52 logMAR vs. 2.11 ± 1.49 logMAR; P = 0.025).
  
  
  CONCLUSIONS
  An early rise in IOP is a significant risk factor which compromises the visual outcome of patients undergoing diabetic vitrectomy.
authors.affiliation: Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Yog Raj
authors.initials: YR
authors.lastname: Sharma
authors.forename: Archna
authors.initials: A
authors.lastname: Pruthi
authors.forename: Raj Vardhan
authors.initials: RV
authors.lastname: Azad
authors.forename: Atul
authors.initials: A
authors.lastname: Kumar
authors.forename: Rashim
authors.initials: R
authors.lastname: Mannan
mesh_terms: D000328:Adult; D003930:Diabetic Retinopathy / Q000601:surgery*; D005139:Eyeglasses; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000209:etiology* / Q000503:physiopathology*; D011446:Prospective Studies; D013997:Time Factors; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects*