title: Biotransformation of quinazoline and phthalazine by Aspergillus niger.
abstract: Cultures of Aspergillus niger NRRL-599 in fluid Sabouraud medium were grown with quinazoline and phthalazine for 7 days. Metabolites were purified by high-performance liquid chromatography and identified by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Quinazoline was oxidized to 4-quinazolinone and 2,4-quinazolinedione, and phthalazine was oxidized to 1-phthalazinone.
authors.affiliation: National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. john.sutherland@fda.hhs.gov
authors.forename: John B
authors.initials: JB
authors.lastname: Sutherland
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Heinze
authors.forename: Laura K
authors.initials: LK
authors.lastname: Schnackenberg
authors.forename: James P
authors.initials: JP
authors.lastname: Freeman
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Williams
mesh_terms: D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010793:Phthalazines / Q000378:metabolism*; D011799:Quinazolines / Q000378:metabolism*
chemical_list: D003470:Culture Media; D010793:Phthalazines; D011799:Quinazolines; C081989:2,4(1H,3H)-quinazolinedione; C043388:phthalazine