title: Low incidence of abacavir hypersensitivity reaction among African children initiating antiretroviral therapy.
abstract: Hypersensitivity reactions are reported in approximately 5% of adults receiving abacavir, but there are few published data in children. Among 1150 African children receiving antiretroviral therapy in a randomized trial, suspected hypersensitivity reactions to abacavir were rare (0.3%; 95% CI, 0.01-0.9). Patients were managed successfully through the provision of clear guidelines and education of clinical staff, children, and their caregivers.
authors.affiliation: MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute, Entebbe, Uganda.
authors.forename: Patricia
authors.initials: P
authors.lastname: Nahirya-Ntege
authors.forename: Victor
authors.initials: V
authors.lastname: Musiime
authors.forename: Bethany
authors.initials: B
authors.lastname: Naidoo
authors.forename: Sabrina
authors.initials: S
authors.lastname: Bakeera-Kitaka
authors.forename: Kusum
authors.initials: K
authors.lastname: Nathoo
authors.forename: Paula
authors.initials: P
authors.lastname: Munderi
authors.forename: Peter
authors.initials: P
authors.lastname: Mugyenyi
authors.forename: Adeodata
authors.initials: A
authors.lastname: Kekitiinwa
authors.forename: Mutsa F
authors.initials: MF
authors.lastname: Bwakura-Dangarembizi
authors.forename: Jane
authors.initials: J
authors.lastname: Crawley
mesh_terms: D000293:Adolescent; D000349:Africa; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D015224:Dideoxynucleosides / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D015994:Incidence; D007223:Infant; D008297:Male; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D000099227:Abacavir