title: [Protective effects of glucagon-like peptide 2 on intestinal ischemia/reperfusion injury in mice].
abstract: OBJECTIVE
  To investigate the protective effects of glucagon-like peptide 2(GLP-2) on intestinal ischemia/reperfusion (I/R) injury in mice.
  
  
  METHODS
  Intestinal ischemia/reperfusion model in mice were set up and 32 mice of Kunming species were divided randomly into 4 groups (n=8): Sham group, I/R group, I/R + GLP-2 group and I/R + glutamine group. The morphologic changes of intestinal mucosa were observed under LM. The villus height and crypt depth of intestine, the activity of diamine oxidase (DAO) in intestine and bacterial translocation rates of mesenteric lymph nodes (MLN) were detected.
  
  
  RESULTS
  Compared with sham operation group, the intestinal villi were sloughed in I/R group with decreased villus height and crypt depth (P < 0.01), the DAO activities were decreased (P < 0.01), and MLN bacterial translocation rates were increased (P < 0.05). While GLP-2 administration improved the villus damage, increased DAO activity (P < 0.01), and decreased MLN bacterial translocation rates (P < 0.05), compared with I/R group.
  
  
  CONCLUSIONS
  GLP-2 have protective effects on intestinal morphology and barrier function after ischemia/reperfusion injury in mice.
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian 116027, China.
authors.forename: Li-li
authors.initials: LL
authors.lastname: Guan
authors.forename: De-zheng
authors.initials: DZ
authors.lastname: Gong
authors.forename: Nan
authors.initials: N
authors.lastname: Tian
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zou
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D053767:Glucagon-Like Peptide 2 / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007421:Intestine, Small / Q000098:blood supply; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015427:Reperfusion Injury / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D053767:Glucagon-Like Peptide 2