title: Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves.
abstract: Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves' ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use.
authors.affiliation: Departamento Farmacêutico, Faculdade de Farmácia e Bioquímica, Universidade Federal de Juiz de Fora, Campus Universitário, Martelos, 36036-330, Juiz de Fora, MG, Brazil; E-Mails: dinafgs@hotmail.com (L.L.F.); glauciemar@gmail.com (G.D.-V.V.); jose.pinho@ufjf.edu.br (J.J.R.G.P.); hytomani@yahoo.com (C.H.Y.).
authors.forename: Leopoldina Leonor
authors.initials: LL
authors.lastname: Fagundes
authors.forename: Glauciemar Del-Vechio
authors.initials: GD
authors.lastname: Vieira
authors.forename: José de Jesus R G
authors.initials: Jde J
authors.lastname: de Pinho
authors.forename: Célia Hitomi
authors.initials: CH
authors.lastname: Yamamoto
authors.forename: Maria Silvana
authors.initials: MS
authors.lastname: Alves
authors.forename: Paulo César
authors.initials: PC
authors.lastname: Stringheta
authors.forename: Orlando Vieira
authors.initials: OV
authors.lastname: de Sousa
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000431:Ethanol / Q000737:chemistry; D051379:Mice; D059225:Nociception / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D019664:Polygonaceae / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D000431:Ethanol