title: Neuroprotective effects of diallyl trisulfide in SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis.
abstract: Diallyl trisulfide (DATS) is one of the major constituents in garlic oil and has been documented to transcriptionally activate phase II enzymes. The purpose of this study is to evaluate the effects of DATS in prolonging disease duration and survival in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). SOD1-G93A transgenic mice were randomly divided into DATS-treated group (80mg/kg/d, p.o.) and vehicle-treated group at disease onset stage. Oral administration of DATS beginning at clinical onset stage significantly prolonged disease duration and extended life span for about one week. DATS treatment induced HO-1 and reduced GFAP expression in the lumbar spinal cord of SOD1-G93A transgenic mice. This study indicates that DATS has multifunctional neuroprotective effects in SOD1-G93A transgenic mice.
authors.affiliation: Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China.
authors.forename: Yansu
authors.initials: Y
authors.lastname: Guo
authors.forename: Kunxi
authors.initials: K
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Zhongyao
authors.initials: Z
authors.lastname: Li
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Yin
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Xu
authors.forename: Weisong
authors.initials: W
authors.lastname: Duan
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
mesh_terms: D000498:Allyl Compounds / Q000627:therapeutic use*; D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology* / Q000235:genetics / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005737:Garlic; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009821:Oils; D011897:Random Allocation; D013440:Sulfides / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000498:Allyl Compounds; D018696:Neuroprotective Agents; D009821:Oils; D013440:Sulfides; C042577:diallyl trisulfide; C109415:SOD1 G93A protein; D013482:Superoxide Dismutase