title: Life and destruction: ubiquitin-mediated proteolysis in aging and longevity.
abstract: The ubiquitin/proteasome system (UPS) regulates the turnover of improperly folded and damaged proteins to maintain protein homeostasis (proteostasis), cellular function, and viability. It is commonly thought that an age-related impairment of the UPS affects general proteostasis networks, which causes enhanced protein aggregation and contributes to normal aging. Recent studies identified the existence of ubiquitin-dependent degradation pathways that specifically control lifespan regulators, suggesting additional roles for ubiquitylation in aging and longevity.
authors.affiliation: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) at the Institute for Genetics, University of Cologne Zülpicher Str 47a, 50674 Cologne Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Hoppe