title: Role of reflux in tracheoesophageal fistula problems after laryngectomy.
abstract: OBJECTIVE
  The purpose of this 2-year prospective nonrandomized study was to investigate the relationship between pathological supraesophageal reflux and the occurrence of speech fistula complications, especially severe fistula enlargement, in patients who underwent total laryngectomy and prosthetic voice restoration.
  
  
  METHODS
  We objectively assessed the presence of reflux disease using 24-hour dual-probe pH monitoring in 60 laryngectomized patients, correlated the incidence of tracheoesophageal fistula complications with the severity of reflux, and assessed the risk of problems by determining the absolute number of reflux events at the level of the speech fistula, the reflux area index score, and the DeMeester score.
  
  
  RESULTS
  All patients with fistula enlargement showed highly pathological results in the diagnostic tests for reflux disease. Depending on reflux severity, the relative risk of developing fistula complications was up to 10 times higher for these patients.
  
  
  CONCLUSIONS
  We found a significant correlation between the occurrence of tracheoesophageal fistula complications and the severity of supraesophageal reflux. Potential chronic irritation of the esophageal and tracheal mucosa can possibly contribute to the development of these problems. If the presence of reflux disease has been confirmed by 24-hour dual-probe pH monitoring, patients with fistula complications should be treated with proton pump inhibitors.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, German Armed Forces Hospital of Ulm, Ulm, Germany.
authors.forename: Kai J
authors.initials: KJ
authors.lastname: Lorenz
authors.forename: Laura
authors.initials: L
authors.lastname: Grieser
authors.forename: Theresa
authors.initials: T
authors.lastname: Ehrhart
authors.forename: Heinz
authors.initials: H
authors.lastname: Maier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery; D007825:Laryngectomy; D007831:Larynx, Artificial; D008875:Middle Aged; D009092:Mucous Membrane / Q000528:radiation effects; D015999:Multivariate Analysis; D011446:Prospective Studies; D014138:Tracheoesophageal Fistula / Q000150:complications* / Q000473:pathology