title: Comparison of oral versus sublingual piroxicam during postoperative pain management after lower third molar extraction.
abstract: In this study, 53 patients received piroxicam, administered orally or sublingually, after undergoing removal of symmetrically positioned lower third molars, during two separate appointments. This study used a randomized, blind, cross-over protocol. Objective and subjective parameters were recorded for comparison of postoperative results for 7 days after surgery. Patients treated with oral or sublingual piroxicam reported low postoperative pain scores. The patients who received piroxicam orally took a similar average amount of analgesic rescue medication compared with patients who received piroxicam sublingually (p>0.05). Patients exhibited similar values for mouth opening measured just before surgery and immediately following suture removal 7 days later (p>0.05), and showed no significant differences between routes of piroxicam administration for swelling control during the second or seventh postoperative days (p>0.05). In summary, pain, trismus and swelling after lower third molar extraction, independent of surgical difficulty, could be controlled by piroxicam 20mg administered orally or sublingually and no significant differences were observed between the route of delivery used in this study.
authors.affiliation: Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: P A K
authors.initials: PA
authors.lastname: Trindade
authors.forename: F P M
authors.initials: FP
authors.lastname: Giglio
authors.forename: B L
authors.initials: BL
authors.lastname: Colombini-Ishikiriama
authors.forename: A M
authors.initials: AM
authors.lastname: Calvo
authors.forename: K C S
authors.initials: KC
authors.lastname: Modena
authors.forename: D A
authors.initials: DA
authors.lastname: Ribeiro
authors.forename: T J
authors.initials: TJ
authors.lastname: Dionísio
authors.forename: D T
authors.initials: DT
authors.lastname: Brozoski
authors.forename: J R P
authors.initials: JR
authors.lastname: Lauris
authors.forename: F A C
authors.initials: FA
authors.lastname: Faria
authors.forename: C F
authors.initials: CF
authors.lastname: Santos
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000284:Administration, Oral; D000286:Administration, Sublingual; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004487:Edema / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008964:Molar, Third / Q000601:surgery*; D010027:Osteotomy; D010149:Postoperative Pain / Q000188:drug therapy*; D010894:Piroxicam / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy; D016059:Range of Motion, Articular / Q000502:physiology; D016037:Single-Blind Method; D013997:Time Factors; D014081:Tooth Extraction; D016896:Treatment Outcome; D014313:Trismus / Q000188:drug therapy; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D000082:Acetaminophen