title: Dynamic formation of oriented patches in chondrocyte cell cultures.
abstract: Growth factors have a significant impact not only on the growth dynamics but also on the phenotype of chondrocytes (Barbero et al. in J. Cell. Phys. 204:830-838, 2005). In particular, as chondrocytes approach confluence, the cells tend to align and form coherent patches. Starting from a mathematical model for fibroblast populations at equilibrium (Mogilner et al. in Physica D 89:346-367, 1996), a dynamic continuum model with logistic growth is developed. Both linear stability analysis and numerical solutions of the time-dependent nonlinear integro-partial differential equation are used to identify the key parameters that lead to pattern formation in the model. The numerical results are compared quantitatively to experimental data by extracting statistical information on orientation, density and patch size through Gabor filters.
authors.affiliation: Institute of Mathematics, Rheinsprung 21, 4051, Basel, Switzerland. Marcus.Grote@unibas.ch
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Grote
authors.forename: Viviana
authors.initials: V
authors.lastname: Palumberi
authors.forename: Barbara
authors.initials: B
authors.lastname: Wagner
authors.forename: Andrea
authors.initials: A
authors.lastname: Barbero
authors.forename: Ivan
authors.initials: I
authors.lastname: Martin
mesh_terms: D000293:Adolescent; D000368:Aged; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism*; D003198:Computer Simulation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D010641:Phenotype
chemical_list: D036341:Intercellular Signaling Peptides and Proteins