title: Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds.
abstract: Chelating neutral (N,O) and cationic (N,N) first- and second-generation ruthenium(II) arene metallodendrimers based on poly(propyleneimine) dendrimer scaffolds were obtained from dinuclear arene ruthenium precursors by reactions with salicylaldimine and iminopyridyl dendritic ligands, respectively. The N,N cationic complexes were isolated as hexafluorophosphate salts and were characterised by NMR and IR spectroscopy, and MALDI-TOF mass spectrometry. Related mononuclear complexes were obtained in a similar manner and their molecular structures have been determined by X-ray diffraction analysis. The cytotoxicities of the mono- and multinuclear complexes were established using A2780 and A2780cisR human ovarian carcinoma cancer cell lines.
authors.affiliation: Department of Chemistry, University of Cape Town, Rondebosch, 7701, Cape Town, South Africa.
authors.forename: Preshendren
authors.initials: P
authors.lastname: Govender
authors.forename: Anna K
authors.initials: AK
authors.lastname: Renfrew
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Clavel
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Smith
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D002614:Chelating Agents / Q000494:pharmacology*; D050091:Dendrimers / Q000494:pharmacology*; D051379:Mice; D011126:Polypropylenes / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D050091:Dendrimers; D011126:Polypropylenes; D017975:Ruthenium Compounds; C443641:poly(propyleneimine)