title: Formulation and in vitro characterization of spray dried microspheres of amoxicillin.
abstract: The purpose of the present study was to design muco-adhesive chitosan microspheres containing amoxicillin. Chitosan microspheres with a small particle size and good sphericity were prepared by a spray-drying method followed by chemical treatment with a chemical crosslinking agent (glutaraldehyde). Parameters affecting the crosslinking extent of the crosslinking time and the concentration of the crosslinker agent. Crosslinked spray-dried chitosan microspheres were analyzed for their morphological aspects, particle size, drug entrapment efficiency, swelling percent and in vitro drug release. Batch M4 with a drug polymer ratio of 1:2, dissolved in minimum concentration of acetic acid solution treated with glutaraldehyde, was found to be optimal giving controlled drug release for 10 h. It was found that both the increase of glutaraldehyde concentration and crosslinking duration decreased the swelling capacity of chitosan microspheres. This could be directly correlated to drug release from the microspheres.
authors.affiliation: S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-Gozaria Highway Kherva, Gujarat, India. jignyasha26@yahoo.com
authors.forename: Jignyasha A
authors.initials: JA
authors.lastname: Raval
authors.forename: Jayvadan K
authors.initials: JK
authors.lastname: Patel
authors.forename: Madhabhai M
authors.initials: MM
authors.lastname: Patel
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000268:Adhesiveness; D000658:Amoxicillin / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations; D003890:Desiccation; D004339:Drug Compounding; D005976:Glutaral / Q000737:chemistry; D006801:Humans; D008863:Microspheres; D010316:Particle Size; D011108:Polymers; D012995:Solubility; D014783:Viscosity
chemical_list: D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D011108:Polymers; D000658:Amoxicillin; D048271:Chitosan; D019342:Acetic Acid; D005976:Glutaral