title: The role of the TGF-β coreceptor endoglin in cancer.
abstract: Endoglin (CD105) is an auxiliary membrane receptor of transforming growth factor beta (TGF-β) that interacts with type I and type II TGF-β receptors and modulates TGF-β signaling. Endoglin is overexpressed in the tumor-associated vascular endothelium, where it modulates angiogenesis. This feature makes endoglin a promising target for antiangiogenic cancer therapy. In addition, recent studies on human and experimental models of carcinogenesis point to an important tumor cell-autonomous role of endoglin by regulating proliferation, migration, invasion, and metastasis. These studies suggest that endoglin behaves as a suppressor of malignancy in experimental and human epithelial carcinogenesis, although it can also promote metastasis in other types of cancer. In this review, we evaluate the implication of endoglin in tumor development underlying studies developed in our laboratories in recent years.
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid, Madrid, Spain. eperez@bbm1.ucm.es
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pérez-Gómez
authors.forename: Gaelle
authors.initials: G
authors.lastname: Del Castillo
authors.forename: Santibáñez
authors.initials: S
authors.lastname: Juan Francisco
authors.forename: Jose Miguel
authors.initials: JM
authors.lastname: López-Novoa
authors.forename: Carmelo
authors.initials: C
authors.lastname: Bernabéu
authors.forename: Miguel
authors.initials: M
authors.lastname: Quintanilla
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism* / Q000502:physiology; D002465:Cell Movement; D049109:Cell Proliferation; D000071063:Endoglin; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism* / Q000502:physiology; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta