title: [Arrhythmia triggered by stretching rabbit left ventricles and the block effect of streptomysin].
abstract: OBJECTIVE
  To observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, and to investigate its possible mechanisms.
  
  
  METHODS
  Stretch (120 mmHg, 50 ms) was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit cardiac activity and streptomycin (500 micromol/L) was used to identify the mechanism.
  
  
  RESULTS
  Stretch in the end of action potential caused arrhythmia (P < 0.05) and streptomycin blocked the above effect (P < 0.05).
  
  
  CONCLUSIONS
  Streptomycin could block the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, which indicates that stretch-activated ion channels involve it.
authors.affiliation: Department of Physiology, Capital Medical University, Beijing 100069, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wei
authors.forename: Zhi-Fei
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Huang
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Niu
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects*; D011434:Proprioception; D011817:Rabbits; D013307:Streptomycin / Q000494:pharmacology*
chemical_list: D007473:Ion Channels; D013307:Streptomycin