title: Functionalized cyclic RGD peptidomimetics: conjugable ligands for αvβ3 receptor imaging.
abstract: The α(v)β(3) integrin is an adhesion molecule involved in physiological and pathological angiogenesis as well as in tumor invasion and metastasis, and therefore, there is a strong interest in developing novel agents interacting with this molecule. We report the synthesis and characterization of fluorescent α(v)β(3) integrin probes and their use to visualize integrin α(v)β(3) expression on human normal and cancer cells. The fluorescent probes we describe here may be of use for noninvasive imaging of α(V)β(3) integrin expression also in vivo.
authors.affiliation: CNR-Istituto di Scienze e Tecnologie Molecolari (ISTM), Milan, Italy. daniela.arosio@istm.cnr.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Arosio
authors.forename: Leonardo
authors.initials: L
authors.lastname: Manzoni
authors.forename: Elena M V
authors.initials: EM
authors.lastname: Araldi
authors.forename: Andrea
authors.initials: A
authors.lastname: Caprini
authors.forename: Eugenia
authors.initials: E
authors.lastname: Monferini
authors.forename: Carlo
authors.initials: C
authors.lastname: Scolastico
mesh_terms: D045744:Cell Line, Tumor; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000378:metabolism; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000032:analysis* / Q000378:metabolism; D008024:Ligands; D057054:Molecular Imaging / Q000379:methods*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000378:metabolism; D057786:Peptidomimetics / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005456:Fluorescent Dyes; D039302:Integrin alphaVbeta3; D008024:Ligands; D010456:Peptides, Cyclic; D057786:Peptidomimetics; C507169:cyclic arginine-glycine-aspartic acid peptide