title: Keratocystic odontogenic tumour: systematic review.
abstract: OBJECTIVE
  The aim of this review is to evaluate the principal clinical and conventional radiographic features of non-syndromic keratocystic odontogenic tumour (KCOT) by systematic review (SR), and to compare the frequencies between four global groups.
  
  
  METHODS
  The databases searched were the PubMed interface of Medline and LILACS. Only those reports of KCOTs that occurred in a series of consecutive cases, in the reporting authors' caseload, were considered.
  
  
  RESULTS
  51 reports, of 49 series of cases, were included in the SR. 11 SR-included series were in languages other than English. KCOTs affected males more frequently and were three times more prevalent in the mandible. Although the mean age at first presentation was 37 years, the largest proportion of cases first presented in the third decade. The main symptom was swelling. Over a third were found incidentally. Nearly two-thirds displayed buccolingual expansion. Over a quarter of cases recurred. Only a quarter of all SR-included reported series of cases included details of at least one radiological feature. The East Asian global group presented significantly as well-defined, even corticated, multilocular radiolucencies with buccolingual expansion. The KCOTs affecting the Western global group significantly displayed an association with unerupted teeth.
  
  
  CONCLUSIONS
  Long-term follow-up of large series that would have revealed detailed radiographic description and long-term outcomes of non-syndromic KCOT was lacking.
authors.affiliation: Division of Oral & Maxillofacial Radiology, Faculty of Dentistry, UBC, 2199 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. dmacdon@interchange.ubc.ca
authors.forename: D S
authors.initials: DS
authors.lastname: MacDonald-Jankowski
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D016009:Chi-Square Distribution; D005006:Ethnicity; D005060:Europe / Q000453:epidemiology; D005202:Asia, Eastern / Q000453:epidemiology; D006801:Humans; D007633:Keratins; D007843:Latin America / Q000453:epidemiology; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000473:pathology; D008441:Maxillary Neoplasms / Q000000981:diagnostic imaging / Q000208:ethnology / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D009808:Odontogenic Tumors / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000473:pathology; D011859:Radiography; D012744:Sex Ratio; D014481:United States / Q000453:epidemiology
chemical_list: D007633:Keratins