title: [Experimental research of prevention and therapy effect of anisodamine on acute respiratory distress syndrome (ARDS)].
abstract: OBJECTIVE
  To study preventive and therapeutic effect of anisodamine on acute respiratory distress syndrome(ARDS) induced by oleic acid and their mechanism of action.
  
  
  METHODS
  Model of ARDS was made in rabbits by oleic acid (OA). The effect of anisodamine on the malondialdehyde (MDA), fibronectin (FN), lactate dehydrogenase (LDH) and acid phosphatase (ACP) in plasma, and superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate and pathological examination of lung were observed.
  
  
  RESULTS
  The administration of anisodamine before and after 30 minutes of injection OA decreased MDA, LDH and ACP, prevented the reduction of SOD, FN and PS. Compared with ARDS group, there was marked difference between the two, and alleviated lung injury.
  
  
  CONCLUSIONS
  Anisodamine possesses preventive and therapeutic effects on ARDS by inhibiting lipid peroxidation and stabilizing membranes.
authors.affiliation: North Coal Medical College, Tangshan 063000, China.
authors.forename: You-Ling
authors.initials: YL
authors.lastname: Jing
authors.forename: Yan-Lei
authors.initials: YL
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Chun-Xiu
authors.initials: CX
authors.lastname: Zhao
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Kong
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D019301:Oleic Acid; D011817:Rabbits; D011897:Random Allocation; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*
chemical_list: D016166:Free Radical Scavengers; D012991:Solanaceous Alkaloids; C003922:anisodamine; D019301:Oleic Acid