title: [Acquired von Willebrand's disease type 2A following arteriovenous fistula for haemodialysis?].
abstract: Acquired von Willebrand's disease (aVWD) is considered to be an underestimated cause of unexplained bleeding. Adsorption of von Willebrand factor (VWF) to tumour cells or hydroxyethyl starch and elimination of VWF by autoantibodies as well as shear stress-induced mechanical alteration of VWF with concomitant cleavage by enzymes may lead to an acquired deficiency of VWF and a bleeding disorder. We report a 39-year-old woman who developed spontaneous bleeding five years after surgical creation of an arteriovenous fistula (AVF) for haemodialysis treatment. AVWD type 2A was diagnosed after successful renal transplantation. One year after surgical closure of the AVF, the aVWD could not be verified again. Thus, the aVWD may have developed because of altered blood flow and shear stress inside the arteriovenous fistula.
authors.affiliation: Klinik für Anästhesiologie, Intensiv-, Notfall-, Transfusionsmedizin und Schmerztherapie, Evangelisches Krankenhaus Bielefeld. Klaus.Leimkuehler@evkb.de
authors.forename: K
authors.initials: K
authors.lastname: Leimkühler
authors.forename: F
authors.initials: F
authors.lastname: Bach
authors.forename: S
authors.initials: S
authors.lastname: Kuhlmann
authors.forename: B
authors.initials: B
authors.lastname: Feidicker
authors.forename: M U
authors.initials: MU
authors.lastname: Heim
authors.forename: C
authors.initials: C
authors.lastname: Susemihl
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: F
authors.initials: F
authors.lastname: Mertzlufft
mesh_terms: D000328:Adult; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D001780:Blood Coagulation Tests; D005260:Female; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000097:blood / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology*; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D056728:von Willebrand Disease, Type 2 / Q000097:blood / Q000175:diagnosis / Q000209:etiology*