title: Non-alcoholic steatohepatitis (NASH) and oral lichen planus: a rare occurrence.
abstract: Oral lichen planus (OLP) is frequently associated with hepatitis C virus infection but uncommonly with other causes of liver disorder. The authors report the case of a 41-year-old male patient with a clinical and histological diagnosis of OLP who presented with a marked alteration of the transaminase values, with no signs of past or present HBV, HCV, HGV or TTV infection. The patient did not consume alcohol and no exposure to hepatotoxic substances was reported. All autoantibodies were negative. Hepatic fine needle biopsy showed macrovesicular steatosis with a slight chronic portal inflammatory infiltrate and signs of siderosis. Iron metabolism was slightly altered. Genetic tests showed a heterozygotic mutation for hereditary haemochromatosis gene (HLA-H C282Y) but not for HLA-H63D. The patient presented slight insulin resistance but had normal glycaemic values. The results are consistent with a diagnosis of non-alcoholic steatohepatitis (NASH). This is the first reported case of NASH associated with OLP.
authors.affiliation: Division of Otorhinolaryngology, Department of Clinical Physiopathology, Oral Medicine Section, University of Turin, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Conrotto
authors.forename: E
authors.initials: E
authors.lastname: Bugianesi
authors.forename: L
authors.initials: L
authors.lastname: Chiusa
authors.forename: M
authors.initials: M
authors.lastname: Carrozzo
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D003545:Cysteine / Q000235:genetics; D005234:Fatty Liver / Q000150:complications*; D006432:Hemochromatosis / Q000235:genetics; D000071020:Hemochromatosis Protein; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I; D006801:Humans; D017676:Lichen Planus, Oral / Q000150:complications*; D008297:Male; D008565:Membrane Proteins; D009154:Mutation / Q000235:genetics; D012806:Siderosis / Q000150:complications; D014443:Tyrosine / Q000235:genetics
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D014443:Tyrosine; D003545:Cysteine