title: [Effect of Ang II on PDGF receptor expression in vascular smooth muscle cell].
abstract: OBJECTIVE
  To study the effect of angiotensin II (Ang II) on platelet-derived growth factor(PDGF) receptor expression in vascular smooth muscle cell(VSMC).
  
  
  METHODS
  Restenosis model was established by balloon injury in rat aorta. The morphologic change and level of Ang II were measured at 14th day after operation. The expression of PDGF-beta receptor was detected by Western blot. The cultured VSMC pretreated with or without losartan were treated with Ang II.
  
  
  RESULTS
  Compared with sham group, the sections of injured aorta showed marked intimal thickening with large numbers of VSMCs proliferation throughout intima and media, the level of Ang II obviously increased by 78.8% (P < 0.05), the expression of PDGF-beta receptor significantly increased by 83.9% (P < 0.05) at 14th day after operation. The expression of PDGF-beta receptor in cultured VSMC treated with Ang II was higher than that of control group (P < 0.01). The effect of Ang II was inhibited remarkably by pretreatment with losartan.
  
  
  CONCLUSIONS
  Ang II can stimulate PDGF receptor expression in VSMC, it may be an important mechanism of Ang II-induced VSMC proliferation.
authors.affiliation: Department of Pathophysiology, Xinxiang Medical College, Xinxiang 453003, China.
authors.forename: Yin-ping
authors.initials: YP
authors.lastname: Sun
authors.forename: Dong-qi
authors.initials: DQ
authors.lastname: Xing
authors.forename: Xiang-ting
authors.initials: XT
authors.lastname: Wang
authors.forename: Sao-yong
authors.initials: SY
authors.lastname: Hu
authors.forename: Hua
authors.initials: H
authors.lastname: Bai
authors.forename: Li-ling
authors.initials: LL
authors.lastname: Wu
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000473:pathology; D002478:Cells, Cultured; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism*
chemical_list: D000804:Angiotensin II; D017479:Receptors, Platelet-Derived Growth Factor