title: The usefulness of albumin-adjusted ischemia-modified albumin index as early detecting marker for ischemic stroke.
abstract: This study was conducted to investigate whether albumin-adjusted ischemia-modified albumin index (IMA index) is more sensitive and accurate than ischemia-modified albumin (IMA) as early detection marker of ischemic stroke, and to compare IMA and IMA index in progression and non-progression of ischemic stroke. This case-control study was done at an emergency medical center of a university hospital. 52 patients with neurological symptoms were enrolled (28 Ischemic Stroke Group and 24 Non-Stroke Group). In the ROC analysis of IMA index to diagnose stroke, area under the curve (AUC) was 0.990 (cutoff value 91.4; 95% CI: 0.970-1.000; sensitivity: 96.4%; specificity 95.8%). The AUC for IMA value was 0.928 (cutoff value 98 U/ml; 95% CI 0.857-0.999; sensitivity 89.3%; specificity 88.5%). [corrected] The difference between progression (n = 12) and non-progression group (n = 16) in IMA and IMA index were statistically insignificant (p > 0.01). IMA index was more sensitive than conventional IMA value as diagnostic biomarker of stroke, however, arguable as a predictive biomarker for progression of ischemic stroke.
authors.affiliation: Emergency Department, Ajou University School of Medicine, Woncheon-dong, Yeongtong-gu, Suwon, 443-721, Republic of Korea.
authors.forename: Jung Hwan
authors.initials: JH
authors.lastname: Ahn
authors.forename: Sang Cheon
authors.initials: SC
authors.lastname: Choi
authors.forename: Wee Gyo
authors.initials: WG
authors.lastname: Lee
authors.forename: Yoon Seok
authors.initials: YS
authors.lastname: Jung
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000473:pathology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D012709:Serum Albumin / Q000032:analysis*; D018709:Statistics, Nonparametric; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology
chemical_list: D015415:Biomarkers; D012709:Serum Albumin