title: NOD1-Mediated Mucosal Host Defense against Helicobacter pylori.
abstract: Infection of the stomach with Helicobacter pylori is an important risk factor for gastritis, peptic ulcer, and gastric carcinoma. Although it has been well established that persistent colonization by H. pylori is associated with adaptive Th1 responses, the innate immune responses leading to these Th1 responses are poorly defined. Recent studies have shown that the activation of nucleotide-binding oligomerization domain 1 (NOD1) in gastric epithelial cells plays an important role in innate immune responses against H. pylori. The detection of H. pylori-derived ligands by cytosolic NOD1 induces several host defense factors, including antimicrobial peptides, cytokines, and chemokines. In this paper, we review the molecular mechanisms by which NOD1 contributes to mucosal host defense against H. pylori infection of the stomach.
authors.affiliation: Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC Room 5W3940, 10 Center Drive, Bethesda, MD 20892, USA.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Naoki
authors.initials: N
authors.lastname: Asano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kitani
authors.forename: Ivan J
authors.initials: IJ
authors.lastname: Fuss
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Chiba
authors.forename: Warren
authors.initials: W
authors.lastname: Strober