title: [Association of DNA methyltransferase 3B gene polymorphism with early-onset schizophrenia].
abstract: OBJECTIVE
  To investigate the association of DNA methyltransferase 3B (DNMT3B) gene polymorphism with the development of early-onset schizophrenia.
  
  
  METHODS
  A single nucleotide polymorphism (rs6119954) of DNMT3B gene was genotyped in 279 early-onset schizophrenic patients and 395 healthy controls, using TaqMan SNP Genotyping Assays. To detect the interaction between the DNMT3B gene and environmental factors, the prenatal information of the patients was collected.
  
  
  RESULTS
  Genotype distribution of the rs6119954 locus was significantly different between patients and controls (Chi-square = 12.27, P< 0.01). The frequency of the G allele of this locus was significantly higher in patients than in controls (Chi-square = 12.76, P< 0.01). The G allele was highly associated with an earlier age of onset (P= 0.026). No interaction between the DNMT3B gene and environmental factors was found.
  
  
  CONCLUSIONS
  DNMT3B gene is associated with early-onset schizophrenia and rs6119954 may plays an important role in age of onset of schizophrenia.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Yiru
authors.initials: Y
authors.lastname: Fang
authors.forename: Bin
authors.initials: B
authors.lastname: Xie
authors.forename: Ya-song
authors.initials: YS
authors.lastname: Du
authors.forename: Wen-hong
authors.initials: WH
authors.lastname: Cheng
authors.forename: Dong-xiang
authors.initials: DX
authors.lastname: Wang
authors.forename: Shun-ying
authors.initials: SY
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D004777:Environment; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult; D000097584:DNA Methyltransferase 3B
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases; D000097584:DNA Methyltransferase 3B