title: [The expressional alterations of CSF-1R after ischemic injury of cerebral cortex].
abstract: OBJECTIVE
  To observe the expressional alterations of colony stimulating factor-1 receptor (CSF-1R) after ischemic injury of cerebral cortex, and study the function of colony stimulating factor-1 (CSF-1)/CSF-1R signal during the process of ischemic injury and repair of central nervous system (CNS).
  
  
  METHODS
  We examined the distribution and expression of CSF-1R in normal brain tissues and ischemic brain tissues by immunohistology and Western blot analysis.
  
  
  RESULTS
  The expression of CSF-1R in neurons could be up-regulated by ischemic injury in CNS.
  
  
  CONCLUSIONS
  CSF-1/CSF-1R might take part in the process of ischemic injury and repair.
authors.affiliation: Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Dong Hui
authors.initials: DH
authors.lastname: Yu
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Zeng-Min
authors.initials: ZM
authors.lastname: Tian
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Liu
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Ge
authors.forename: Chang-Man
authors.initials: CM
authors.lastname: Zhou
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply*; D005260:Female; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000378:metabolism; D011897:Random Allocation; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015427:Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor