title: [Collagen-polyvinylpyrrolidone: a new therapeutic option for treatment of sequelae after radical mastectomy in women with breast cancer. Preliminary study].
abstract: BACKGROUND
  Approximately 30% of women who undergo mastectomy without reconstructive treatment due to breast cancer present sequelae. These include paresthesias, keloid healing, hypoesthesia, lymphedema and limitation of the function of the ipsilateral upper extremity. We undertook this study to present the results using collagen-polyvinylpyrrolidone (Clg- Pvp) as treatment for posmastectomy sequelae in women with breast cancer.
  
  
  METHODS
  We conducted a unicentric, longitudinal and prospective clinical trial between August 1, 2007 and July 31, 2008. Included variables were age, lymphedema, limitation of the function of the ipsilateral upper extremity, collapse of the wound, keloid healing, paresthesias, and appearance of the surgical area. The appearance of the surgical area (aesthetic aspect) was evaluated before and 6 months after treatment was initiated. Clg-Pvp was administered weekly for a 6-month period.
  
  
  RESULTS
  Seven women were included with a median age of 49 years (range: 40-72 years). One patient (14.28%) presented lymphedema, two patients (28.57%) presented collapse of the wound, two patients (28.57%) had keloid healing, three patients (42.85%) experienced paresthesias, five patients (71.4%) reported pain, and five patients (71.4%) reported limitation of the function of the ipsilateral upper extremity. At the completion of the treatment, aesthetic improvement was statistically significant (p = 0.0020, Mann-Whitney U test).
  
  
  CONCLUSIONS
  Clinical and aesthetic results are good after application of Clg-Pvp for treating sequelae in women with breast cancer who underwent mastectomy without reconstructive surgery.
authors.affiliation: Departamento de Cirugía Plástica, Hospital General Regional 36, Instituto Mexicano del Seguro Social, Puebla, México. alvaro.montielj@imss.gob.mx
authors.forename: Rafael
authors.initials: R
authors.lastname: Ruiz-Eng
authors.forename: Alvaro
authors.initials: A
authors.lastname: Montiel-Jarquín
authors.forename: Raúl
authors.initials: R
authors.lastname: de la Rosa-Pérez
authors.forename: Aurelio
authors.initials: A
authors.lastname: López-Colombo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gómez-Conde
authors.forename: Leticia
authors.initials: L
authors.lastname: Zamudio-Huerta
mesh_terms: D000328:Adult; D000368:Aged; D001132:Arm; D001943:Breast Neoplasms / Q000601:surgery*; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004954:Esthetics; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007627:Keloid / Q000209:etiology / Q000517:prevention & control; D008197:Lymph Node Excision / Q000009:adverse effects*; D008209:Lymphedema / Q000209:etiology / Q000517:prevention & control*; D015409:Mastectomy, Radical / Q000009:adverse effects*; D008875:Middle Aged; D010292:Paresthesia / Q000209:etiology / Q000517:prevention & control*; D011205:Povidone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D016059:Range of Motion, Articular; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003879:Dermatologic Agents; C120488:collagen-PVP; D003094:Collagen; D011205:Povidone