title: Nitric oxide concentrations are normal and unrelated to activity level in chronic fatigue syndrome: a case-control study.
abstract: OBJECTIVE
  since patients with chronic fatigue syndrome (CFS) often present elevated levels of nitric oxide (NO) and low levels of physical activity, this study aimed at revealing possible correlations between NO concentration and physical activity.
  
  
  METHODS
  thirty CFS patients and 29 age- and gender-matched sedentary controls wore an accelerometer for one week and underwent venous blood sampling at the beginning and the end of the week.
  
  
  RESULTS
  CFS patients were significantly less active (p=0.001), but no significant differences in the amounts of NO (p=0.464 and 0.569) or interaction between NO levels and activity levels in either the CFS patients or controls were revealed.
  
  
  CONCLUSIONS
  these results provide further evidence for reduced activity levels in CFS patients, but refute there being any interaction between the amount of blood NO and activity level in both groups. The blood NO was neither predictive of, nor dependent on the activity level in CFS.
authors.affiliation: Division of Musculoskeletal Physiotherapy, Artesis University College (AHA), Department of Health Sciences, Van Aertselaerstraat 31, 2170 Merksem, Belgium.
authors.forename: Mira
authors.initials: M
authors.lastname: Meeus
authors.forename: Inge
authors.initials: I
authors.lastname: VAN Eupen
authors.forename: Jasmien
authors.initials: J
authors.lastname: Hondequin
authors.forename: Lieve
authors.initials: L
authors.lastname: DE Hauwere
authors.forename: Daphne
authors.initials: D
authors.lastname: Kos
authors.forename: Jo
authors.initials: J
authors.lastname: Nijs
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015444:Exercise; D015673:Fatigue Syndrome, Chronic / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*
chemical_list: D009569:Nitric Oxide