title: Endo-polysaccharide of Phellinus igniarius exhibited anti-tumor effect through enhancement of cell mediated immunity.
abstract: The purpose of this study was to assess the anti-tumor and immunomodulatory effects of PIE on tumor cells Sarcoma 180 and Hepatoma 22 in implanted mice. The monosaccharide composition of PIE was analyzed by GC. The results demonstrated that PIE monosaccharide composition was n(Xyl): n(Man): n(Fuc): n(Glc): n(Gal)=2.3: 1: 6.4: 22.1: 19.83. The oral administration of PIE characteristically inhibited the growth of S180 and H22 cells and increased the life span. The concentrations of serum IL-2 and IL-18 were significantly increased in the S180 implanted mice fed with PIE in the doses of 500 mg/kg and 250 mg/kg compared with those in control (p<0.01). The concentrations of serum IL-2 were significantly increased in H22 implanted mice in the doses of 500 mg/kg and 250 mg/kg compared with those in control (p<0.01).
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agricultural University Changchun, Jilin, 130118 PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Jingzhi
authors.initials: J
authors.lastname: Pan
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Meng
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D016207:Cytokines / Q000276:immunology; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D025282:Mycelium / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D011134:Polysaccharides