title: MRI-BASED PROSTATE BRACHYTHERAPY SEED LOCALIZATION.
abstract: A magnetic resonance imaging (MRI) pulse sequence and a corresponding image processing algorithm to localize prostate brachytherapy seeds during or after therapy are presented. Inversion-Recovery with ON-resonant water suppression (IRON) is an MRI methodology that generates positive contrast in regions of magnetic field susceptibility, as created by prostate brachytherapy seeds. Phantoms comprising of several materials found in brachytherapy seeds were created to assess the usability of the IRON pulse sequence for imaging seeds. Resulting images show that seed materials are clearly visible with high contrast using IRON, agreeing with theoretical predictions. A seed localization algorithm to process IRON images demonstrates the potential of this imaging technique for seed localization and dosimetry.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Nathanael
authors.initials: N
authors.lastname: Kuo
authors.forename: Junghoon
authors.initials: J
authors.lastname: Lee
authors.forename: Clare
authors.initials: C
authors.lastname: Tempany
authors.forename: Matthias
authors.initials: M
authors.lastname: Stuber
authors.forename: Jerry
authors.initials: J
authors.lastname: Prince