title: Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010.
abstract: Neisseria gonorrhoeae has developed resistance to most of the available therapeutic antimicrobials. The susceptibility to extended-spectrum cephalosporins, the last remaining first-line treatment option, is decreasing globally. This report describes the first two cases outside Japan of verified gonorrhoea clinical failures using internationally recommended first-line cefixime treatment. Enhanced awareness and more frequent follow-up examination, test-of-cure and appropriate verification/falsification of presumed clinical treatment failures, involving several clinical and laboratory parameters should be strongly emphasised worldwide.
authors.affiliation: Swedish Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden. magnus.unemo@orebroll.se
authors.forename: M
authors.initials: M
authors.lastname: Unemo
authors.forename: D
authors.initials: D
authors.lastname: Golparian
authors.forename: G
authors.initials: G
authors.lastname: Syversen
authors.forename: D F
authors.initials: DF
authors.lastname: Vestrheim
authors.forename: H
authors.initials: H
authors.lastname: Moi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020682:Cefixime / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000008:administration & dosage; D024881:Drug Resistance, Bacterial; D006069:Gonorrhea / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D009664:Norway; D016133:Polymerase Chain Reaction; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D020682:Cefixime