title: Acute coagulopathy and early deaths post major trauma.
abstract: OBJECTIVE
  Acute traumatic coagulopathy is observed in 10-25% of patients post major trauma and its management forms an integral part of haemostatic resuscitation. The identification and treatment of this coagulopathy is difficult and there is uncertainty regarding optimal therapeutic guidelines during the early phases of trauma resuscitation. This study aimed to examine the association between acute coagulopathy and early deaths post major trauma.
  
  
  METHODS
  A retrospective review of data over a 5 year period was performed to determine the associations between variables considered to contribute to mortality for adult major trauma patients (Injury Severity Score (ISS)>15) receiving blood transfusions as part of their initial resuscitation. Early death, defined as death in ED, or death in the operating theatre (OT), Intensive Care Unit (ICU) or wards within 24 h of admission was the primary end-point. Patients with non-survivable head injury on initial imaging were excluded. Univariate associations were calculated and multivariable logistic regression analysis was used to determine independent associations with mortality.
  
  
  RESULTS
  There were 772 patients included in this study with a median ISS of 29 (19-41), with 91.7% blunt trauma. All-cause in-hospital mortality was 17.5%, while 77 (9.7%) patients died early. Increasing age (OR 1.04), a GCS of 3-8 (OR 5.05), and the presence of acute coagulopathy (OR 8.77) were significant independent variables associated with early death.
  
  
  CONCLUSIONS
  Acute traumatic coagulopathy, independent of injury severity, transfusion practice or other physiological markers for haemorrhage, was associated with early death in major trauma patients requiring a blood transfusion. Early recognition and management of coagulopathy, independent of massive transfusion guidelines, may improve outcome from trauma resuscitation. Further studies are required for the early recognition of acute traumatic coagulopathy to enable the development of an evidence base for management.
authors.affiliation: Emergency & Trauma Centre, The Alfred Hospital, Melbourne, VIC, Australia. b.mitra@alfred.org.au
authors.forename: Biswadev
authors.initials: B
authors.lastname: Mitra
authors.forename: Peter A
authors.initials: PA
authors.lastname: Cameron
authors.forename: Alfredo
authors.initials: A
authors.lastname: Mori
authors.forename: Mark
authors.initials: M
authors.lastname: Fitzgerald
mesh_terms: D000208:Acute Disease; D000328:Adult; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D001803:Blood Transfusion / Q000379:methods / Q000401:mortality*; D042241:Early Diagnosis; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015601:Injury Severity Score; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012151:Resuscitation / Q000379:methods / Q000401:mortality*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D014949:Wounds, Nonpenetrating / Q000150:complications / Q000401:mortality* / Q000628:therapy; D014950:Wounds, Penetrating / Q000150:complications / Q000401:mortality* / Q000628:therapy