title: Effect of laparoscopic ovarian drilling on vascular endothelial growth factor and ovarian stromal blood flow using 3-dimensional power Doppler.
abstract: OBJECTIVE
  To determine, by using 3-dimensional power Doppler ultrasonography, the effect of laparoscopic ovarian drilling (LOD) on the serum level of vascular endothelial growth factor (VEGF) and ovarian stromal blood flow changes in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  A prospective controlled clinical study was conducted on 26 clomiphene-resistant women with PCOS who were scheduled for LOD and a control group of 22 fertile regularly menstruating women. VEGF and 3 ovarian Doppler indices-vascularization index, flow index, and vascularization flow index-were measured and compared between the 2 groups, and before and after LOD in the PCOS group.
  
  
  RESULTS
  Serum VEGF and the Doppler indices of ovarian stromal blood flow were significantly higher in the PCOS group than in the control group. Serum VEGF and the ovarian stromal blood flow Doppler indices were significantly reduced in the PCOS group after LOD.
  
  
  CONCLUSIONS
  Increased vascularity in PCOS demonstrated by Doppler blood flow measurements might be explained by the high level of VEGF. LOD reduced ovarian vascularization and serum VEGF.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt. mbhry@hotmail.com
authors.forename: Manal M
authors.initials: MM
authors.lastname: El Behery
authors.forename: Abdalla E
authors.initials: AE
authors.lastname: Diab
authors.forename: Hala
authors.initials: H
authors.lastname: Mowafy
authors.forename: Moustafa A
authors.initials: MA
authors.lastname: Ebrahiem
authors.forename: Amal E
authors.initials: AE
authors.lastname: Shehata
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D010053:Ovary / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000601:surgery*; D011446:Prospective Studies; D018608:Ultrasonography, Doppler / Q000379:methods*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D055815:Young Adult
chemical_list: D042461:Vascular Endothelial Growth Factor A