title: MicroRNAs in chronic lymphocytic leukemia.
abstract: Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Recent research, conducted primarily in basic science laboratories, has indicated a role for microRNAs (miRNAs) in the pathogenesis and prognosis of this disease. MiRNAs are small, non-coding, functional RNAs, that mediate post-transcriptional inhibition of messenger RNAs. Because miRNA expression levels in CLL patients differ from that of normal patients, there may be a role for these novel small molecules as biomarkers in this disease.
authors.affiliation: Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Ward
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Tsongalis
authors.forename: Prabhjot
authors.initials: P
authors.lastname: Kaur
mesh_terms: D019008:Drug Resistance, Neoplasm / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53