title: Candida parapsilosis meningitis associated with Gliadel (BCNU) wafer implants.
abstract: A 58-year old male presented with meningitis associated with subgaleal and subdural collections 6 weeks following a temporal craniotomy for resection of recurrent glioblastoma multiforme and Gliadel wafer implantation. Candida parapsilosis was cultured from cerebrospinal fluid (CSF) and Gliadel wafers removed during surgical debridement. He was successfully treated with liposomal amphotericin B. To our knowledge, this is the first reported case of Candida parapsilosis meningitis secondary to Gliadel wafer placement.
authors.affiliation: Department of Clinical Microbiology, Beaumont Hospital, Dublin, Ireland. de.obrien@svuh.ie
authors.forename: Deirdre
authors.initials: D
authors.lastname: O'Brien
authors.forename: Meaghan
authors.initials: M
authors.lastname: Cotter
authors.forename: Chor Hiang
authors.initials: CH
authors.lastname: Lim
authors.forename: Muhammad T
authors.initials: MT
authors.lastname: Sattar
authors.forename: Edmond
authors.initials: E
authors.lastname: Smyth
authors.forename: Fidelm
authors.initials: F
authors.lastname: Fitzpatrick
mesh_terms: D001672:Biocompatible Materials; D001932:Brain Neoplasms / Q000601:surgery; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology*; D002330:Carmustine; D003131:Combined Modality Therapy / Q000379:methods; D003652:Decanoic Acids / Q000627:therapeutic use; D004343:Drug Implants / Q000009:adverse effects*; D005909:Glioblastoma / Q000601:surgery; D006801:Humans; D008297:Male; D016921:Meningitis, Fungal / Q000188:drug therapy / Q000382:microbiology*; D008875:Middle Aged; D011091:Polyesters / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D003652:Decanoic Acids; D004343:Drug Implants; D011091:Polyesters; C055401:decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer; D002330:Carmustine