title: Verrucisidinol and verrucosidinol acetate, two pyrone-type polyketides isolated from a marine derived fungus, Penicillium aurantiogriseum.
abstract: The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene α-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.
authors.affiliation: Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yu
authors.forename: Biao
authors.initials: B
authors.lastname: Ren
authors.forename: Junli
authors.initials: J
authors.lastname: Wei
authors.forename: Caixia
authors.initials: C
authors.lastname: Chen
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Sun
authors.forename: Fuhang
authors.initials: F
authors.lastname: Song
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D010407:Penicillium / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D011753:Pyrones; C556618:verrucosidinol; C556619:verrucosidinol acetate; C048224:verrucosidin