title: Ca²(+) transfer from the ER to mitochondria: channeling cell death by a tumor suppressor.
abstract: The mitochondrial gateway to cell death is a frequent target for tumor suppressors, which largely utilize Bcl-2-dependent apoptotic pathways. Reporting in Science, Giorgi et al. (2010) now show that PML exerts its tumor suppressor function via a distinct mechanism: Ca²(+) transfer from the endoplasmic reticulum to the mitochondria.
authors.affiliation: Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, UK.
authors.forename: Aleck W E
authors.initials: AW
authors.lastname: Jones
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Szabadkai