title: Human papillomavirus and non-muscle invasive urothelial bladder cancer: potential relationship from a pilot study.
abstract: The relationship between urothelial bladder cancer and high-risk human papillomaviruses (HR-HPV) is still a poorly understood entity, even if some studies have supposed a probably correlation. The aim of the present study was to assess the potential relationship between the presence of HR-HPV and non-muscle invasive urothelial bladder cancers (NMIBC). One hundred and thirty-seven subjects (78 patients affected by NMIBC and 59 controls) were recruited in this prospective study. HR-HPV DNA was evaluated both in urine and tumour tissues. Data from patients were compared with data from controls. The relationship between patients and controls, in terms of HR-HPV presence was performed. The relationship between all pathological data and HR-HPV presence in patient group was carried out. HR-HPV DNA in tissue was found in 27 of 78 (34.6%) tumour samples and in 6 of 59 (10.1%) specimens from TUR-P, with a statistically significant difference (p=0.0009; dF=1; χ2=10.98). HR-HPV DNA in urine was found in 36 of 78 (46.1%) samples obtained from patients, whereas in only 8 of 59 (13.5%) samples from controls (p<0.0001: dF=1; χ2=16.37). A statistical significant difference in terms of HR-HPV frequency between high-grade and low-grade urothelial bladder cancer, was found (p=0.032; RR=0.52-95% CI 0.27-0.93; OR=0.34-95% CI 0.13-0.90). In conclusion, this study highlights the correlation between urothelial bladder cancer and high-risk type HPV infection, suggesting the potential etiopathogenetic role of HR-HPV in urothelial bladder cancer development.
authors.affiliation: Department of Urology, Santa Chiara Hospital, Largo Medaglie d'Oro 9, Trento, Italy. ktommy@libero.it
authors.forename: Tommaso
authors.initials: T
authors.lastname: Cai
authors.forename: Sandra
authors.initials: S
authors.lastname: Mazzoli
authors.forename: Francesca
authors.initials: F
authors.lastname: Meacci
authors.forename: Gabriella
authors.initials: G
authors.lastname: Nesi
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Geppetti
authors.forename: Gianni
authors.initials: G
authors.lastname: Malossini
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bartoletti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification; D002277:Carcinoma / Q000453:epidemiology / Q000209:etiology* / Q000652:urine / Q000821:virology; D016022:Case-Control Studies; D004279:DNA, Viral / Q000032:analysis / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology / Q000652:urine / Q000821:virology; D010865:Pilot Projects; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000652:urine / Q000821:virology; D019459:Urothelium / Q000473:pathology
chemical_list: D004279:DNA, Viral