title: Surface microstructure and cell compatibility of calcium silicate and calcium phosphate composite coatings on Mg-Zn-Mn-Ca alloys for biomedical application.
abstract: A calcium silicate and calcium phosphate (CaSiO(3)/CaHPO(4)·2H(2)O) composite coating was applied by a chemical reaction to Mg-Zn-Mn-Ca alloy to improve its biocompatiblity. The surface microstructure was observed by scanning electronic microscopy (SEM) and the surface bioactivity was assessed by a cell interaction experiment. SEM observation showed that a microporous layer was formed on the surface of Mg-Zn-Mn-Ca alloy. It was shown by XRD that the reaction layer was mainly composed of CaHPO(4)·2H(2)O and a small amount of CaSiO(3). In vitro cell experiments indicated that osteoblasts showed good adhesion, high growth rates and proliferation characteristics on the coated Mg-Zn-Mn-Ca alloy, indicating that the surface cytocompatibility of Mg-Zn-Mn-Ca alloy was significantly improved by the calcium phosphate coating.
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Du
authors.forename: Zunjie
authors.initials: Z
authors.lastname: Wei
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Erlin
authors.initials: E
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Zuo
authors.forename: Lianping
authors.initials: L
authors.lastname: Du
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000818:Animals; D017610:Calcium Compounds / Q000737:chemistry / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology*; D055664:Electrochemical Techniques; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008422:Materials Testing / Q000379:methods*; D008670:Metals / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects; D044367:Phase Transition / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017640:Silicates / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties / Q000187:drug effects; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D017610:Calcium Compounds; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D008670:Metals; D017640:Silicates; C020243:calcium phosphate; C031293:calcium silicate