title: [Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats].
abstract: OBJECTIVE
  To study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats.
  
  
  METHODS
  The fever model was established by intracerebroventricular injection of IL-1beta in rats. The effect of naloxone on the body temperature of feverrats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected.
  
  
  RESULTS
  Naloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01).
  
  
  CONCLUSIONS
  Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA.
authors.affiliation: Department of Physiology, China Medical University, Shenyang 110001, China.
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Qin
authors.forename: Yu
authors.initials: Y
authors.lastname: Cao
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Shu-fen
authors.initials: SF
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D005334:Fever / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020665:Septum of Brain / Q000187:drug effects / Q000378:metabolism
chemical_list: D001127:Arginine Vasopressin; D009270:Naloxone; D000242:Cyclic AMP