title: Meiotic studies of a 38,XY/39,XXY mosaic boar.
abstract: Klinefelter's syndrome (KS) is the most common sex chromosome abnormality identified in human males. This syndrome is generally associated with infertility. Men with KS may have a 47,XXY or a 46,XY/47,XXY karyotype. Studies carried out in humans and mice suggest that only XY cells are able to enter and complete meiosis. These cells could originate from the XY cells present in mosaic patients or from XXY cells that have lost one X chromosome. In pig, only 3 cases of pure 39,XXY have been reported until now, and no meiotic analysis was carried out. For the first time in pig species we report the analysis of a 38,XY/39,XXY boar and describe the origin of the supplementary X chromosome and the chromosomal constitutions of the germ and Sertoli cells.
authors.affiliation: UMR 444 INRA-ENVT Génétique Cellulaire, Toulouse, France. a.pinton@envt.fr
authors.forename: A
authors.initials: A
authors.lastname: Pinton
authors.forename: H
authors.initials: H
authors.lastname: Barasc
authors.forename: I
authors.initials: I
authors.lastname: Raymond Letron
authors.forename: M
authors.initials: M
authors.lastname: Bordedebat
authors.forename: N
authors.initials: N
authors.lastname: Mary
authors.forename: K
authors.initials: K
authors.lastname: Massip
authors.forename: N
authors.initials: N
authors.lastname: Bonnet
authors.forename: A
authors.initials: A
authors.lastname: Calgaro
authors.forename: A M
authors.initials: AM
authors.lastname: Dudez
authors.forename: K
authors.initials: K
authors.lastname: Feve
authors.forename: J
authors.initials: J
authors.lastname: Riquet
authors.forename: M
authors.initials: M
authors.lastname: Yerle
authors.forename: A
authors.initials: A
authors.lastname: Ducos
mesh_terms: D000818:Animals; D033481:Chromosomes, Mammalian; D008297:Male; D008540:Meiosis; D018895:Microsatellite Repeats; D012730:Sex Chromosomes; D034421:Sus scrofa / Q000235:genetics*; D013737:Testis / Q000166:cytology / Q000378:metabolism