title: Epithelial-mesenchymal transition in the skin.
abstract: Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, and malignant cutaneous cancers, including squamous cell carcinoma and melanoma.
authors.affiliation: Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. motonaka@med.uoeh-u.ac.jp
authors.forename: Motonobu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D008545:Melanoma / Q000209:etiology / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000254:growth & development* / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
chemical_list: D000071250:Snail Family Transcription Factors; D014157:Transcription Factors