title: Analgesic use during pregnancy and risk of infant leukaemia: a Children's Oncology Group study.
abstract: BACKGROUND
  Infant leukaemia is likely initiated in utero.
  
  
  METHODS
  We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.
  
  
  RESULTS
  With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios=0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.
  
  
  CONCLUSIONS
  Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia.
authors.affiliation: Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, 420 Delaware Street SE, MMC 422, Minneapolis, MN 55455, USA. ognja001@umn.edu
authors.forename: S
authors.initials: S
authors.lastname: Ognjanovic
authors.forename: C
authors.initials: C
authors.lastname: Blair
authors.forename: L G
authors.initials: LG
authors.lastname: Spector
authors.forename: L L
authors.initials: LL
authors.lastname: Robison
authors.forename: M
authors.initials: M
authors.lastname: Roesler
authors.forename: J A
authors.initials: JA
authors.lastname: Ross
mesh_terms: D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000009:adverse effects* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000209:etiology*; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D055815:Young Adult
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin