title: Liver transplantation for severe hepatic graft-versus-host disease in two children after hematopoietic stem cell transplantation.
abstract: Chronic graft-versus-host disease (GVHD) is a frequent complication of bone marrow transplantation (BMT). After the skin, the liver is the second, most frequent target of GVHD, which presenting with hyperbilirubinemia, elevated liver enzymes, and coagulopathy. Progressive destruction of small intrahepatic bile ducts causes vanishing bile duct syndrome and leads to end-stage liver disease. We report 2 successful cases of orthotopic liver transplantation performed in children with severe GVHD after hematopoietic stem cell transplantation from a matched unrelated donor (HSCT-MUD).
authors.affiliation: Department of Gastroenterology, Hepatology, and Immunology, Children's Memorial Health Institute, Warsaw, Poland. m.teisseyre@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Teisseyre
authors.forename: J
authors.initials: J
authors.lastname: Teisseyre
authors.forename: P
authors.initials: P
authors.lastname: Kalicinski
authors.forename: B
authors.initials: B
authors.lastname: Wolska-Kusnierz
authors.forename: H
authors.initials: H
authors.lastname: Ismail
authors.forename: E
authors.initials: E
authors.lastname: Bernatowska
authors.forename: M
authors.initials: M
authors.lastname: Markiewicz-Kijewska
authors.forename: A
authors.initials: A
authors.lastname: Ostoja-Chyzynska
authors.forename: I
authors.initials: I
authors.lastname: Jankowska
authors.forename: P
authors.initials: P
authors.lastname: Kluge
authors.forename: J
authors.initials: J
authors.lastname: Pawlowska
authors.forename: M
authors.initials: M
authors.lastname: Szymczak
mesh_terms: D002648:Child; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016031:Liver Transplantation; D008297:Male
chemical_list: D007166:Immunosuppressive Agents