title: Effects of human defensin-α(1)on Trypanosoma cruzi trypomastigotes in vitro.
abstract: Human defensin-α(1)is a biologically active peptide exhibiting a dose-dependent trypanocidal effect in vitro against trypomastigotes and amastigotes of Trypanosoma cruzi line Tulahuen. This effect is determined by fragmentation of parasite DNA reducing the capacity of passaged T. cruzi to invade HeLa cells.
authors.affiliation: Department of Microbiology and Immunology, Meharry Medical College, Nashville, TN, USA.
authors.forename: Yu E
authors.initials: YE
authors.lastname: Kleschenko
authors.forename: L P
authors.initials: LP
authors.lastname: Karpenko
authors.forename: F
authors.initials: F
authors.lastname: Villalta
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D023082:Defensins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D014349:Trypanosoma cruzi / Q000502:physiology*
chemical_list: D023082:Defensins; C058181:insect defensin A