title: Gene expression and association analysis of the epithelial membrane protein 1 gene in major depressive disorder in the Japanese population.
abstract: The epithelial membrane protein 1 (EMP1) plays a role in neuronal differentiation and neurite outgrowth, which are involved in the pathogenesis of major depressive disorder (MDD). We sought to determine whether the EMP1 gene is implicated in MDD. We determined the mRNA expression levels of the EMP1 gene in peripheral-blood leukocytes of patients and control subjects (n=27 each). Next, we performed case-control association analyses (MDD, n=182; controls, n=350) in the Japanese population. The level of expression of the EMP1 mRNA was significantly lower in medication-free patients compared with control subjects (P<0.001). The association analysis revealed an absence of association between the polymorphisms studied and MDD, whereas a gender-specific association was observed between male controls and male patients for marker rs7315725 (permutation P=0.039). Our results suggest that the EMP1 gene may be implicated in the pathophysiology of MDD in the Japanese population.
authors.affiliation: Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 18-15 Kuramoto-cho 3, Tokushima 770-8509, Japan. nktk@clin.med.tokushima-u.ac.jp
authors.forename: Masahito
authors.initials: M
authors.lastname: Nakataki
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Iga
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Eriko
authors.initials: E
authors.lastname: Yoshimoto
authors.forename: Kanami
authors.initials: K
authors.lastname: Kodera
authors.forename: Shin-ya
authors.initials: SY
authors.lastname: Watanabe
authors.forename: Hongwei
authors.initials: H
authors.lastname: Song
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000097:blood / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007564:Japan; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000097:blood; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C097051:epithelial membrane protein-1