title: [Prophylactic and therapeutic efficacies of Ingavirin, a novel Russian chemotherapeutic, with respect to influenza pathogen A (H5N1)].
abstract: The experimental study of the Ingavirin efficacy against the influenza virus A (H5N1) on intranasally-infected albino mice vs. Tamiflue and Arbidol showed that when used for the prophylaxis, urgent prophylaxis and therapy it was effective in the protectiom of the animals from death. The efficient dose for the prophylaxis of the influenza infection was 5 mg/kg (protective efficacy of 46.7%) and for the urgent prophylaxis and therapy it was 15 mg/kg (protective efficacy of 40.0 and 35.0% respectively).
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Loginova
authors.forename: S V
authors.initials: SV
authors.lastname: Borisevich
authors.forename: O M
authors.initials: OM
authors.lastname: Shkliaeva
authors.forename: V A
authors.initials: VA
authors.lastname: Maksimov
authors.forename: V P
authors.initials: VP
authors.lastname: Bondarev
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
mesh_terms: D000577:Amides / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002208:Caproates; D003998:Dicarboxylic Acids / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007211:Indoles / Q000627:therapeutic use; D053124:Influenza A Virus, H5N1 Subtype; D007251:Influenza, Human / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D053139:Oseltamivir / Q000627:therapeutic use; D013440:Sulfides
chemical_list: D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D007093:Imidazoles; D007211:Indoles; D053139:Oseltamivir; C539419:pentanedioic acid imidazolyl ethanamide; C086979:umifenovir; D013440:Sulfides