title: Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells.
abstract: A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by (1)H NMR, mass spectrometry analysis and Gaussian calculations.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Hu
authors.forename: Jiangli
authors.initials: J
authors.lastname: Fan
authors.forename: Honglin
authors.initials: H
authors.lastname: Li
authors.forename: Kedong
authors.initials: K
authors.lastname: Song
authors.forename: Song
authors.initials: S
authors.lastname: Wang
authors.forename: Guanghui
authors.initials: G
authors.lastname: Cheng
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Peng
mesh_terms: D000042:Absorption; D002470:Cell Survival; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D006710:Homocysteine / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D005456:Fluorescent Dyes; D006710:Homocysteine; D003545:Cysteine