title: Ecto-F₁-ATPase: a moonlighting protein complex and an unexpected apoA-I receptor.
abstract: Mitochondrial ATP synthase has been recently detected at the surface of different cell types, where it is a high affinity receptor for apoA-I, the major protein component in high density lipoproteins (HDL). Cell surface ATP synthase (namely ecto-F₁-ATPase) expression is related to different biological effects, such as regulation of HDL uptake by hepatocytes, endothelial cell proliferation or antitumor activity of Vγ9/Vδ2 T lymphocytes. This paper reviews the recently discovered functions and regulations of ecto-F₁-ATPase. Particularly, the role of the F₁-ATPase pathway(s) in HDL-cholesterol uptake and apoA-I-mediated endothelial protection suggests its potential importance in reverse cholesterol transport and its regulation might represent a potential therapeutic target for HDL-related therapy for cardiovascular diseases. Therefore, it is timely for us to better understand how this ecto-enzyme and downstream pathways are regulated and to develop pharmacologic interventions.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U1048, Toulouse F-31000, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Vantourout
authors.forename: Claudia
authors.initials: C
authors.lastname: Radojkovic
authors.forename: Laeticia
authors.initials: L
authors.lastname: Lichtenstein
authors.forename: Véronique
authors.initials: V
authors.lastname: Pons
authors.forename: Eric
authors.initials: E
authors.lastname: Champagne
authors.forename: Laurent O
authors.initials: LO
authors.lastname: Martinez
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism*; D002470:Cell Survival; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D008099:Liver / Q000378:metabolism; D025261:Mitochondrial Proton-Translocating ATPases / Q000378:metabolism; D008958:Models, Molecular; D009369:Neoplasms / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D002784:Cholesterol; D000251:Adenosine Triphosphatases; C027201:ectoATPase; D025261:Mitochondrial Proton-Translocating ATPases