title: Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.
abstract: We have identified desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions. This opening improves access to receptors, for example, CD46 and Her2/neu, that are trapped in intercellular junctions. In addition to complete virions, dodecahedral particles (PtDds), formed by excess amounts of viral capsid proteins, penton base and fiber during viral replication, can trigger DSG-2-mediated opening of intercellular junctions as shown by studies with recombinant Ad3 PtDds. Our findings shed light on adenovirus biology and pathogenesis and may have implications for cancer therapy.
authors.affiliation: University of Washington, Division of Medical Genetics, Seattle, Washington, USA.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Wang
authors.forename: Zong-Yi
authors.initials: ZY
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Jonas
authors.initials: J
authors.lastname: Persson
authors.forename: Ines
authors.initials: I
authors.lastname: Beyer
authors.forename: Thomas
authors.initials: T
authors.lastname: Möller
authors.forename: Dilara
authors.initials: D
authors.lastname: Koyuncu
authors.forename: Max R
authors.initials: MR
authors.lastname: Drescher
authors.forename: Robert
authors.initials: R
authors.lastname: Strauss
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Zhang
authors.forename: James K
authors.initials: JK
authors.lastname: Wahl
authors.forename: Nicole
authors.initials: N
authors.lastname: Urban
authors.forename: Charles
authors.initials: C
authors.lastname: Drescher
authors.forename: Akseli
authors.initials: A
authors.lastname: Hemminki
authors.forename: Pascal
authors.initials: P
authors.lastname: Fender
authors.forename: André
authors.initials: A
authors.lastname: Lieber
mesh_terms: D000258:Adenovirus Infections, Human / Q000503:physiopathology; D000260:Adenoviruses, Human / Q000472:pathogenicity / Q000502:physiology*; D000595:Amino Acid Sequence; D001943:Breast Neoplasms / Q000235:genetics; D002051:Burkitt Lymphoma; D002460:Cell Line; D045744:Cell Line, Tumor; D051301:Desmoglein 2 / Q000502:physiology*; D005260:Female; D006367:HeLa Cells / Q000821:virology; D006801:Humans; D020014:K562 Cells; D008969:Molecular Sequence Data; D011991:Receptors, Virus / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D012141:Respiratory Tract Infections / Q000503:physiopathology / Q000821:virology; D020349:Surface Plasmon Resonance; D014161:Transduction, Genetic; D014552:Urinary Tract Infections / Q000503:physiopathology / Q000821:virology; D053585:Virus Attachment
chemical_list: C495314:DSG2 protein, human; D051301:Desmoglein 2; D011991:Receptors, Virus; C085301:adenovirus receptor