title: Resolution of iris neovascularization following chemoreduction of retinoblastoma.
abstract: The authors report a case of advanced retinoblastoma (group E) with iris neovascularization. A 30-month-old girl was diagnosed as having group B retinoblastoma in the right eye and group E retinoblastoma and iris neovascularization with an intraocular pressure of 13 mm Hg in the left eye. The tumors were treated with six cycles of chemotherapy using vincristine (0.9 mg/m(2)), carboplatin (336 mg/m(2)), and etoposide (90 mg/m(2)). At 1 month of follow-up, there was dramatic regression of the retinoblastoma in the left eye and complete resolution of the iris neovascularization, which remained stable at 3 months of follow-up. Chemotherapy is an effective conservative treatment for advanced retinoblastoma and can successfully salvage eyes with neovascularization, particularly before the onset of glaucoma.
authors.affiliation: Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: Jinali
authors.initials: J
authors.lastname: Patel
authors.forename: Kiran
authors.initials: K
authors.lastname: Turaka
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use; D002675:Child, Preschool; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007498:Iris / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016896:Treatment Outcome; D014463:Ultrasonography; D014750:Vincristine / Q000627:therapeutic use; D014792:Visual Acuity / Q000502:physiology
chemical_list: D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin