title: Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopause women.
abstract: OBJECTIVE
  To evaluate the effects of treatment with Trifolium pratense on climacteric symptoms and sexual satisfaction in postmenopausal women.
  
  
  METHODS
  This is a prospective, randomized, double-blind, placebo-controlled study. Initially, 120 women aged 45-65 years with menopausal symptoms, more than 12-month amenorrhea and no treatment in the past six months were selected. The participants were then divided into two groups: TG – receiving 40 mg Trifolium pratense, 1 capsule/day; PG – receiving placebo capsules containing lactose (control), 1 capsule/day. The duration of treatment was 12 months. The patients underwent clinical and laboratory evaluation before treatment and at four, eight and 12 months of treatment. The Kupperman Menopausal Index and the Golombok Rust Inventory of Sexual Satisfaction (GRISS) were used. At the end of the study, each group comprised 50 patients.
  
  
  RESULTS
  According to the Kupperman Menopausal Index, there was significant improvement in menopausal symptoms after four months of treatment, especially in relation to hot flashes, when compared to baseline data in both groups. However, no significant differences were observed between groups. There was no improvement in sexual satisfaction after treatment.
  
  
  CONCLUSIONS
  A 12-month treatment with a daily dose of 40 mg Trifolium pratense did not yield a significant improvement in menopausal symptoms and sexual satisfaction.
authors.affiliation: departamento de Obstetrícia e Ginecologia da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Cecília
authors.initials: C
authors.lastname: del Giorno
authors.forename: Angela Maggio da
authors.initials: AM
authors.lastname: Fonseca
authors.forename: Vicente Renato
authors.initials: VR
authors.lastname: Bagnoli
authors.forename: Joserita Serrano de
authors.initials: JS
authors.lastname: Assis
authors.forename: José Maria
authors.initials: JM
authors.lastname: Soares
authors.forename: Edmund Chada
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002979:Climacteric / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy; D006801:Humans; D007529:Isoflavones / Q000009:adverse effects*; D008875:Middle Aged; D010549:Personal Satisfaction; D017698:Postmenopause / Q000187:drug effects*; D011446:Prospective Studies; D012725:Sexual Behavior / Q000187:drug effects* / Q000523:psychology; D013997:Time Factors; D029921:Trifolium / Q000009:adverse effects*
chemical_list: D007529:Isoflavones