title: Oxygen-promoted PdCl2-catalyzed ligand-free Suzuki reaction in aqueous media.
abstract: A simple and efficient protocol has been developed for the PdCl(2)-catalyzed ligand-free and aerobic Suzuki reaction of aryl bromides or nitrogen-based heteroaryl bromides with arylboronic acids in good to excellent yields in aqueous ethanol. A systematic investigation on the effect of different atmospheres on the reactivity of the palladium-catalyzed Suzuki reaction has been carried out, the results show that an aerobic atmosphere demonstrates a positive effect on the reactivity of the Suzuki reaction in an aqueous media and a negative effect in a pure organic solvent, which exhibits that the water plays a crucial role for the function of the atmosphere on the palladium-catalyzed ligand-free Suzuki reaction.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Zhongshan Road 158, 116012, Dalian, China. chunliu70@yahoo.com
authors.forename: Chun
authors.initials: C
authors.lastname: Liu
authors.forename: Qijian
authors.initials: Q
authors.lastname: Ni
authors.forename: Pingping
authors.initials: P
authors.lastname: Hu
authors.forename: Jieshan
authors.initials: J
authors.lastname: Qiu
mesh_terms: D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D008024:Ligands; D010165:Palladium; C008756:palladium chloride; D010100:Oxygen