title: Successful management with CHOP for pulmonary lymphomatoid granulomatosis in a dog.
abstract: A 3-year-old, spayed female miniature dachshund was presented for vomiting and anorexia. Thoracic radiographs and CT scan revealed abnormal pulmonary opacities at bilateral caudal lobe. Cytological analysis of the pulmonary mass revealed the presence of large lymphohistiocytic cells and small lymphocytes with occasional neutrophils and plasma cells. An open lung biopsy was performed and a diagnosis of pulmonary lymphomatoid granulomatosis (LYG) was made. The dog was administered CHOP based therapy (modified UW-25), and it survived for 1,022 days after admission. Immunohistochemistry revealed pulmonary lesions consisted of many CD79a positive B cells aggregation and proliferation with prominent angiocentric pattern. This was the first case of canine pulmonary LYG managed by CHOP chemotherapy.
authors.affiliation: Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan.
authors.forename: Singo
authors.initials: S
authors.lastname: Hatoya
authors.forename: Daijiro
authors.initials: D
authors.lastname: Kumagai
authors.forename: Seiko
authors.initials: S
authors.lastname: Takeda
authors.forename: Emi
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Masako
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kuwamura
authors.forename: Kikuya
authors.initials: K
authors.lastname: Sugiura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasai
authors.forename: Jyoji
authors.initials: J
authors.lastname: Yamate
authors.forename: Toshio
authors.initials: T
authors.lastname: Inaba
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D008175:Lung Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D008230:Lymphomatoid Granulomatosis / Q000188:drug therapy / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone