title: Occurrence of allergic bronchopulmonary mycosis in patients with asthma: An Eastern India experience.
abstract: BACKGROUND
  Allergic bronchopulmonary mycosis (ABPM) is a clinical syndrome associated with immune sensitivity to various fungi notably Aspergillus spp. that colonize the airways of asthmatics. Early diagnosis and treatment with systemic corticosteroids is the key in preventing the progression of the disease to irreversible lung fibrosis.
  
  
  OBJECTIVE
  To study the occurrence of ABPM among asthma patients with fungal sensitization attending a chest clinic of a tertiary hospital of eastern India. The clinico-radiological and aetiological profiles are also described.
  
  
  METHODS
  All consecutive patients with asthma presenting to the chest clinic over a period of one year were screened for cutaneous hypersensitivity to 12 common fungal antigens. The skin test positive cases were further evaluated for ABPM using standard criteria.
  
  
  RESULTS
  One hundred and twenty-six asthma patients were screened using twelve common fungal antigens; forty patients (31.74%) were found to be skin test positive, and ABPM was diagnosed in ten patients (7.93%). Of the 10 cases of ABPM, nine cases were those of allergic bronchopulmonary aspergillosis (ABPA) and one case was identified as caused by sensitization to Penicillium spp. A majority of the cases of ABPM had advanced disease and had significantly lower FEV1 compared to non-ABPM skin test positive asthmatics. Central bronchiectasis on high resolution CT scan was the most sensitive and specific among the diagnostic parameters.
  
  
  CONCLUSIONS
  There is a significant prevalence of ABPM in asthma patients attending our hospital and this reinforces the need to screen asthma patients for fungal sensitisation. This will help in early diagnosis and prevention of irreversible lung damage.
authors.affiliation: Department of TB and Respiratory Diseases, Medical College, Kolkata, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Sarkar
authors.forename: Abhijit
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Aloke Gopal
authors.initials: AG
authors.lastname: Ghoshal
authors.forename: Somenath
authors.initials: S
authors.lastname: Kundu
authors.forename: Subhra
authors.initials: S
authors.lastname: Mitra