title: Angiotensin II receptors and drug discovery in cardiovascular disease.
abstract: Hypertension is one of the cardiovascular diseases that might cause cardiovascular remodeling and endothelial dysfunction besides high blood pressure. Angiotensin II (Ang II) receptors are implicated in hypertension. Genetic and epigenetic manipulations of the Ang II receptors play a crucial part in the programming of cardiovascular diseases, and certain variants of the Ang II type 1 and Ang II type 2 receptors are constitutively predisposed to higher cardiovascular risk and hypertension. In this review, we focus on the expression, mode of action of Ang II receptors, and their role in programming the cardiovascular diseases in utero. In addition, we discuss possible therapeutic interventions of Ang II stimulation. Collectively, this information might lead us to new drug designs against cardiovascular diseases.
authors.affiliation: Fetal-Origin Diseases Institute, First Affiliated Hospital of Soochow University, Suzhou 215000, China.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Dasgupta
authors.forename: Lubo
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D055808:Drug Discovery / Q000379:methods; D005260:Female; D006801:Humans; D011247:Pregnancy; D011945:Receptors, Angiotensin / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
chemical_list: D057911:Angiotensin Receptor Antagonists; D002317:Cardiovascular Agents; D011945:Receptors, Angiotensin; D000804:Angiotensin II