title: Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma.
abstract: Plexiform (multinodular) cellular schwannomas are rare tumors, not associated with neurofibromatosis type 1, that occur more often in children and can be congenital. Their biology is benign and is characterized by the tendency to recur locally without being metastatic. Cytogenetic studies in adult cases of schwannoma indicate a complete or partial loss of chromosome 22 as the most common abnormality. Only two cytogenetic studies describe cases in children, one of which concerned a congenital cellular plexiform schwannoma. Here, we report the cytogenetic analysis of a second case in an 8-month-old boy with recurrence of trisomy 17.
authors.affiliation: Department of Pediatric Hematology/Oncology, Giannina Gaslini Institute, Genova, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Tassano
authors.forename: Angela Rita
authors.initials: AR
authors.lastname: Sementa
authors.forename: Elisa
authors.initials: E
authors.lastname: Tavella
authors.forename: Alberto
authors.initials: A
authors.lastname: Garaventa
authors.forename: Claudio
authors.initials: C
authors.lastname: Panarello
authors.forename: Cristina
authors.initials: C
authors.lastname: Morerio
mesh_terms: D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D003582:Cytogenetics; D004452:Echocardiography; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D009362:Neoplasm Metastasis; D009442:Neurilemmoma / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014314:Trisomy