title: Controlled ovarian hyperstimulation for low responders in in vitro fertilization/intracytoplasmic sperm injection: a low-dose flare protocol.
abstract: In this retrospective study of 652 anticipated low response women, the overall clinical outcomes (live birth rate and clinical pregnancy rate [PR]) of low-dose flare (LDF) protocol appeared lower than those of conventional down-regulation (DR) (LDF: 15.1% vs. DR: 20.6% and LDF: 10.3% vs. DR: 17.4%, respectively). The findings that LDF protocol improved the clinical outcome in older women, or when LDF followed an unsuccessful IVF/intracytoplasmic sperm injection (ICSI) cycle with DR (LDF: 19.4% vs. DR: 9.76% and LDF: 13.9% vs. DR: 4.2% respectively), need further evaluation through randomized trials.
authors.affiliation: Centre for Reproductive Medicine, St Bartholomew's Hospital, London, United Kingdom. adrija65@yahoo.com
authors.forename: Adrija Kumar
authors.initials: AK
authors.lastname: Datta
authors.forename: Srisailesh
authors.initials: S
authors.lastname: Vitthala
authors.forename: Amanda
authors.initials: A
authors.lastname: Tozer
authors.forename: Ariel
authors.initials: A
authors.lastname: Zosmer
authors.forename: Luca
authors.initials: L
authors.lastname: Sabatini
authors.forename: Colin
authors.initials: C
authors.lastname: Davis
authors.forename: Talha
authors.initials: T
authors.lastname: Al-Shawaf
mesh_terms: D000328:Adult; D001723:Birth Rate; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D017211:Treatment Failure
chemical_list: D005300:Fertility Agents, Female