title: Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development.
abstract: Gene expression is regulated by the combined action of transcriptional activators and transcriptional repressors. Transcriptional repressors function by recruiting corepressor complexes containing histone-modifying enzymes to specific sites within DNA. Chromatin modifying complexes are subsequently recruited, either directly by transcriptional repressors, or indirectly via corepressor complexes and/or histone modifications, to remodel chromatin into either a transcription-friendly 'open' form or an inhibitory 'closed' form. Transcriptional repressors, corepressors and chromatin modifying complexes play critical roles throughout T cell development. Here, we highlight those genes that function to repress transcription and that have been shown to be required for T cell development.
authors.affiliation: Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Shapiro
authors.forename: Virginia Smith
authors.initials: VS
authors.lastname: Shapiro
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D056970:Co-Repressor Proteins / Q000378:metabolism*; D006801:Humans; D008957:Models, Genetic; D018448:Models, Immunological; D012097:Repressor Proteins / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D056970:Co-Repressor Proteins; D012097:Repressor Proteins