title: Active scaffolds for on-demand drug and cell delivery.
abstract: Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.
authors.affiliation: Soft Active Materials Laboratory, Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
authors.forename: Xuanhe
authors.initials: X
authors.lastname: Zhao
authors.forename: Jaeyun
authors.initials: J
authors.lastname: Kim
authors.forename: Christine A
authors.initials: CA
authors.lastname: Cezar
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Huebsch
authors.forename: Kangwon
authors.initials: K
authors.lastname: Lee
authors.forename: Kamal
authors.initials: K
authors.lastname: Bouhadir
authors.forename: David J
authors.initials: DJ
authors.lastname: Mooney
mesh_terms: D001672:Biocompatible Materials; D018925:Chemokines / Q000008:administration & dosage; D004247:DNA / Q000008:administration & dosage; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels / Q000627:therapeutic use*; D008280:Magnetics / Q000379:methods*; D008942:Mitoxantrone / Q000008:administration & dosage; D011108:Polymers / Q000627:therapeutic use*; D016062:Porosity; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D018925:Chemokines; D003692:Delayed-Action Preparations; D005782:Gels; D011108:Polymers; D004247:DNA; D008942:Mitoxantrone