title: The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.
abstract: OBJECTIVE
  To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility.
  
  
  METHODS
  The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing.
  
  
  RESULTS
  We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results.
  
  
  CONCLUSIONS
  Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
authors.affiliation: Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
authors.forename: Jasper C A
authors.initials: JC
authors.lastname: Broen
authors.forename: Marieke J H
authors.initials: MJ
authors.lastname: Coenen
authors.forename: Blanca
authors.initials: B
authors.lastname: Rueda
authors.forename: Torsten
authors.initials: T
authors.lastname: Witte
authors.forename: Leonid
authors.initials: L
authors.lastname: Padyukov
authors.forename: Lars
authors.initials: L
authors.lastname: Klareskog
authors.forename: Roger
authors.initials: R
authors.lastname: Hesselstrand
authors.forename: Dirk M
authors.initials: DM
authors.lastname: Wuttge
authors.forename: Carmen
authors.initials: C
authors.lastname: Simeon
authors.forename: Norberto
authors.initials: N
authors.lastname: Ortego-Centeno
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
authors.forename: Anna
authors.initials: A
authors.lastname: Pros
authors.forename: Nicholas
authors.initials: N
authors.lastname: Hunzelman
authors.forename: Gabriela
authors.initials: G
authors.lastname: Riemekasten
authors.forename: Alexander
authors.initials: A
authors.lastname: Kreuter
authors.forename: Madelon
authors.initials: M
authors.lastname: Vonk
authors.forename: Rafaella
authors.initials: R
authors.lastname: Scorza
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Beretta
authors.forename: Paulo
authors.initials: P
authors.lastname: Airò
authors.forename: Piet L C M
authors.initials: PL
authors.lastname: van Riel
authors.forename: Robert
authors.initials: R
authors.lastname: Kimberly
authors.forename: Javier
authors.initials: J
authors.lastname: Martin
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Edberg
authors.forename: Timothy R D J
authors.initials: TR
authors.lastname: Radstake
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005060:Europe; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011961:Receptors, Fc / Q000235:genetics*; D012595:Scleroderma, Systemic / Q000235:genetics*
chemical_list: D015703:Antigens, CD; C036832:Fc(alpha) receptor; D011961:Receptors, Fc