title: Effects induced by exercise on lymphocyte β-adrenergic receptors and plasma catecholamine levels in performance horses.
abstract: The effect of dynamic exercise on complete blood cell count, lymphocyte β-adrenergic receptor and plasma catecholamine (adrenaline and noradrenaline) levels in horses performing different disciplines were investigated during rest and after exercise. Blood samples were collected from jumping horses (n=6), Arabian Endurance horses (n=6) and Standardbred trotters (n=6) before and immediately after competition. Dynamic exercise caused a significant increase in red blood cell count (Standardbred trotters: P=0.0012), haemoglobin concentration (jumping horses: P=0.001; Standardbred trotters: P=0.01), haematocrit percentage (Standardbred trotters: P=0.005), neutrophil percentage (jumping horses: P=0.0003), lymphocyte percentage (jumping horses: P=0.0003), monocyte percentage (Standardbred trotters: P=0.0008), lymphocyte β-AR numbers (jumping horses: P=0.01; Arabian Endurance horses: P=0.016; Standardbred trotters: P=0.05), plasma adrenaline concentration (Standardbred trotters: P=0.0001) and plasma noradrenaline levels (Standardbred trotters: P=0.003). It is concluded that acute increases in plasma catecholamine concentrations depended on the exercise performed and may induce up-regulation of β-AR in equine lymphocytes. However, the exact mechanism of β-AR up-regulation still remains unclear.
authors.affiliation: Department of Animal Pathology, University of Turin, Via Leonardo da Vinci 44, Grugliasco Italy. barbara.cuniberti@unito.it
authors.forename: B
authors.initials: B
authors.lastname: Cuniberti
authors.forename: P
authors.initials: P
authors.lastname: Badino
authors.forename: R
authors.initials: R
authors.lastname: Odore
authors.forename: C
authors.initials: C
authors.lastname: Girardi
authors.forename: G
authors.initials: G
authors.lastname: Re
mesh_terms: D000818:Animals; D001772:Blood Cell Count / Q000662:veterinary; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006736:Horses / Q000097:blood / Q000502:physiology*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D004837:Epinephrine