title: [Effects of zinc on activity of NOS and expression of nNOS in hippocampus of acute hypoxic mice].
abstract: OBJECTIVE
  To explore the effect of zinc on vigor of nitric oxide synthase (NOS) and the expression level of neuronal nitric oxide synthase (nNOS) in the hippocampus of acute hypoxic mice and the protective effects of zinc.
  
  
  METHODS
  Model of acute hypoxic mice was duplicated, NADPH-d histochemistry and nNOS immunohistochemistry were used to investigate the changes of NOS in different groups.
  
  
  RESULTS
  Compared with the NS group, the hypoxia endurance of the zinc group was significantly increased; the number of NOS positive neurons and nNOS positive neurons in hippocampus and CA1 were significantly decreased.
  
  
  CONCLUSIONS
  Zinc might play an important role in decreasing the level of NOS in hippocampus to protect the brain against hypoxic damage.
authors.affiliation: Institute of Military Preventive Medicine, Armed Police Force Medical College, Tianjin 300162, China.
authors.forename: Hua-Ren
authors.initials: HR
authors.lastname: Wang
authors.forename: Ji-Sheng
authors.initials: JS
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
chemical_list: D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D015032:Zinc