title: [Experimental investigation of Ingavirin antiviral activity against human parainfluenza virus].
abstract: The Ingavirin antiviral properties with respect to the parainfluenza virus, as an actual human respiratory tract pathogen, were investigated by two methods, i.e. immunoenzymatic analysis and microtetrazolium test. The results showed that along with the immediate antiviral activity Ingavirin had nonspecific cytoprotective properties. While affecting the virus proteins synthesis, Ingavirin lowered the virus cytopathogenic action. The drug significantly decreased the portion of the bronchial epithelium cells killed at the stage of acute infection.
authors.forename: V V
authors.initials: VV
authors.lastname: Zarubaev
authors.forename: V Z
authors.initials: VZ
authors.lastname: Krivitskaia
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
authors.forename: O I
authors.initials: OI
authors.lastname: Kiselev
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects / Q000473:pathology / Q000821:virology; D002208:Caproates; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects*; D019610:Cytoprotection; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007124:Immunoenzyme Techniques; D010252:Paramyxoviridae / Q000187:drug effects*; D018184:Paramyxoviridae Infections / Q000473:pathology / Q000821:virology; D020545:Respiratory Mucosa / Q000187:drug effects / Q000473:pathology / Q000821:virology; D013778:Tetrazolium Salts / Q000737:chemistry
chemical_list: D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D007093:Imidazoles; D013778:Tetrazolium Salts; C539419:pentanedioic acid imidazolyl ethanamide