title: 5-aminolevulinic acid-mediated photodynamic therapy on cervical condylomata acuminata.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (PDT) on cervical condylomata accuminate (CA) and to determine the ultrastructural changes of the lesion after treatment.
  
  
  BACKGROUND
  Although there are many methods to treat cervical CA, a high recurrence rate and cervical scars are troublesome problems.
  
  
  METHODS
  Forty-eight patients with cervical CA were treated with topical 20% ALA gel followed by PDT through a cylindrical fiber with a wavelength of 630 nm of laser light. The treatment was repeated 7 days later if the lesion had not been removed completely. Eight cases were biopsied before and after treatment, and the biopsied lesions were evaluated by electron microscopy.
  
  
  RESULTS
  After the first PDT treatment, the cervical condylomatous lesions were removed completely in 62.5% (30/48). The complete response (CR) rate was 95.8% (46/48) after three treatments. The recurrence rate was 4.4% at the 12-month follow-up. Electron microscopy revealed that ALA-PDT damaged proliferative keratinocytes of CA lesions while the surrounding normal tissue injury was less damaged.
  
  
  CONCLUSIONS
  ALA-PDT is an effective and minimally invasive treatment for cervical CA.
authors.affiliation: Department of Dermatology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P. R. China .
authors.forename: Mu-Kai
authors.initials: MK
authors.lastname: Chen
authors.forename: Di-Qing
authors.initials: DQ
authors.lastname: Luo
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Zeng-Wei
authors.initials: ZW
authors.lastname: Huang
authors.forename: Qin-Fen
authors.initials: QF
authors.lastname: Zhang
authors.forename: Jian-De
authors.initials: JD
authors.lastname: Han
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D015331:Cohort Studies; D003218:Condylomata Acuminata / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D016896:Treatment Outcome; D002577:Uterine Cervical Diseases / Q000473:pathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid