title: [Endogenous catecholamine participates in the action of interleukin-2 on the isolated rat heart].
abstract: OBJECTIVE
  To explore whether endogenous catecholamine participates in the effect of interleukin-2 on the isolated heart.
  
  
  METHODS
  The number of premature ventricular contraction (PVC), left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure(LVEDP), heart rate (HR) and coronary flow(CF)were recorded in isolated Langendorff perfused rat hearts.
  
  
  RESULTS
  (1) 50 U/ml IL-2 increased the PVC number, LVDP LVEDP, HR and CF. (2) Pretreatment of reserpine or propranolol abolished the cardiac effect of IL-2 at 50 U/ml, while pretreatment with phentolamine did not change the effect of IL-2. (3) 200 U/ml IL-2 increased the number of PVC,but did not increase LVDP, LVEDP, HR and CF. (4) After pretreatment of reserpine or propranolol, IL-2 failed to increase the number of PVC, but caused decrease of LVDP, HR and CF, and elevation of LVEDP.
  
  
  CONCLUSIONS
  Endogenous catecholamine mediates the arrhythmogenic, positively chronotropic and inotropic effects of IL-2. IL-2 at 200 U/ml inhibits the cardiac function in the isolated rat heart.
authors.affiliation: Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310031, China.
authors.forename: Lin-lin
authors.initials: LL
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xia
authors.forename: Yue-liang
authors.initials: YL
authors.lastname: Shen
authors.forename: Zhi-guo
authors.initials: ZG
authors.lastname: Ye
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002395:Catecholamines; D007376:Interleukin-2