title: Morphofunctional characteristics of syncytiotrophoblast and content of heat shock protein 70 in it during exacerbation of herpesvirus infection in pregnant women.
abstract: Exacerbation of herpesvirus infection during pregnancy is associated with damage to syncytiotrophoblast inflicted by herpesvirus either directly or via TNF-α (due to contact of NK lymphocytes with villus surface). A sharp decrease in the content of heat shock protein with a molecular weight of 70 Da and activation of caspase-3 were noted in placenta homogenate. This leads to disturbances in syncytiotrophoblast cytosol structure and increase in the relative content of apoptotic nuclei.
authors.affiliation: Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Blagoveshchensk, Russia. Lucenkomt@mail.ru
authors.forename: M T
authors.initials: MT
authors.lastname: Lutsenko
authors.forename: N N
authors.initials: NN
authors.lastname: Dorofienko
authors.forename: I A
authors.initials: IA
authors.lastname: Andrievskaya
mesh_terms: D017209:Apoptosis / Q000502:physiology; D053148:Caspase 3 / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006566:Herpesviridae Infections / Q000503:physiopathology*; D006801:Humans; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology* / Q000378:metabolism* / Q000821:virology
chemical_list: D018840:HSP70 Heat-Shock Proteins; D053148:Caspase 3