title: [Frusemide plus doxazosin therapy for nocturia in patients with BPH/LUTS].
abstract: OBJECTIVE
  To determine the efficacy and safety of a diuretic agent, frusemide, combined with doxazosin in the treatment of nocturia in patients with benign prostate hyperplasia / lower urinary tract symptoms (BPH/LUTS).
  
  
  METHODS
  Sixty-four BPH/LUTS patients with nocturia were equally randomized into two groups, one treated with doxazosin (4 mg/d), and the other with frusemide (40 mg/d) and doxazosin (4 mg/d), given 6 h before sleep, both for 4 weeks. Urine volume, IPSS, QOL, serum electrolytes, plasma osmolality were recorded and compared between the two groups before and after the treatment.
  
  
  RESULTS
  Compared with the doxazosin group, the frusemide plus doxazosin group showed significantly reduced nocturia frequency (P < 0.01), increased daytime urine output (P < 0.01), decreased nocturia urine output (P < 0.01), unchanged total urine output (P > 0.05), improved IPSS and QOL (P < 0.05, P < 0.01), but with no remarkable differences in the levels of serum sodium, potassium, chlorine, and osmotic pressure (P > 0.05).
  
  
  CONCLUSIONS
  Four-week treatment with frusemide plus doxazosin was safe and effective for nocturia in patients with BPH/LUTS.
authors.affiliation: Department of Urology, Union Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350001, China. monkeytreeh4y@sina.com
authors.forename: Shi-yong
authors.initials: SY
authors.lastname: Huang
authors.forename: Shao-xing
authors.initials: SX
authors.lastname: Zhu
authors.forename: Bang-wei
authors.initials: BW
authors.lastname: Zeng
authors.forename: De-sheng
authors.initials: DS
authors.lastname: Zhu
authors.forename: Rong-jin
authors.initials: RJ
authors.lastname: Fang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017292:Doxazosin / Q000627:therapeutic use*; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000188:drug therapy* / Q000209:etiology; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*
chemical_list: D005665:Furosemide; D017292:Doxazosin