title: Fibrinogen and D-dimer analysis of chronic subdural hematomas and computed tomography findings: a prospective study.
abstract: OBJECTIVE
  We investigated the relationship between fibrinolytic factors and computed tomography (CT) findings in patients with chronic subdural hematomas (CSDHs).
  
  
  METHODS
  Thirty-one patients with CSDHs were divided on the basis of CT findings into heterogeneous and homogeneous groups. A sample from the subdural hematoma was obtained at surgery to measure the concentrations of fibrinogen and D-dimer.
  
  
  RESULTS
  The mean level of fibrinogen in the heterogeneous group, including the layering (n=4) and mixed (n=10) type, was 88.2±121.2 mg/dL, whereas in the homogeneous group, including high density (n=2), isodensity (n=9), and low density (n=6) types, it was <25 mg/dL. The concentration of fibrinogen was significantly higher in the heterogeneous group than in the homogeneous group (p=0.006). The mean level of D-dimer in the heterogeneous group was 35,407.9±16,325.5 μg/L, whereas for the homogeneous group it was 1476.4±2091.4 μg/L. The concentration of D-dimer was significantly higher in the heterogeneous group than in the homogeneous group (p<0.001).
  
  
  CONCLUSIONS
  The layering and mixed types of CSDH exhibited higher concentrations of fibrinogen and D-dimer in subdural hematoma than the homogeneous types. These fibrinolytic factors appear to be associated with evolution in CSDHs with heterogeneous density.
authors.affiliation: Department of Neurosurgery, Kyungpook National University Hospital 50, Samduk-2-ga, Jung-gu, Daegu, 700-721, South Korea. nsdoctor@naver.com
authors.forename: Seong-Hyun
authors.initials: SH
authors.lastname: Park
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Kang
authors.forename: Jaechan
authors.initials: J
authors.lastname: Park
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Hwang
authors.forename: Sung-Kyoo
authors.initials: SK
authors.lastname: Hwang
authors.forename: Joo-Kyung
authors.initials: JK
authors.lastname: Sung
authors.forename: In-Suk
authors.initials: IS
authors.lastname: Hamm
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging; D004322:Drainage; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis* / Q000502:physiology; D005340:Fibrinogen / Q000032:analysis* / Q000502:physiology; D020200:Hematoma, Subdural, Chronic / Q000097:blood* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011446:Prospective Studies; D007507:Therapeutic Irrigation; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000933:Antifibrinolytic Agents; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen