title: Apoptosis promotes early tumorigenesis.
abstract: One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.
authors.affiliation: Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA. tangd2@upmc.edu
authors.forename: D
authors.initials: D
authors.lastname: Tang
authors.forename: M T
authors.initials: MT
authors.lastname: Lotze
authors.forename: R
authors.initials: R
authors.lastname: Kang
authors.forename: H J
authors.initials: HJ
authors.lastname: Zeh
mesh_terms: D017209:Apoptosis; D002471:Cell Transformation, Neoplastic; D006801:Humans