title: [Effect of dynorphin A1-13 on C6 glioma cells swelling induced by glutamate].
abstract: OBJECTIVE
  To explore the cell mechanism of brain edema and the effect of dynorphin A1-13 on swelling of C6 glioma cells. Water content of cell are studied by using 3-O-methyl-D-glucose.
  
  
  RESULTS
  (1) Glutamate (0.5, 1.0, 10.0 mmol/L) increased the water content of C6 glioma at an hour. (2) Dynorphin A1-13 could significantly decrease the increasing in water content of C6 glioma cells induced by glutamate. (3) nor-BNI, a antagonist, could inhibit the effect of dynorphin A1-13 on water content of swelling C6 glioma cells.
  
  
  CONCLUSIONS
  Glutamate could induce the swelling of C6 glioma cells. Dynorphin A1-13 could reduce C6 glioma cells swelling induced by glutamate via kappa opioid receptor.
authors.affiliation: Institute of Neuroscience, Department of Neurobiology, Second Military Medical University, Shanghai 200433.
authors.forename: X J
authors.initials: XJ
authors.lastname: Sun
authors.forename: X Q
authors.initials: XQ
authors.lastname: Wang
authors.forename: C H
authors.initials: CH
authors.lastname: Wang
authors.forename: C L
authors.initials: CL
authors.lastname: Lu
mesh_terms: D000818:Animals; D004399:Dynorphins / Q000494:pharmacology*; D005910:Glioma / Q000473:pathology; D018698:Glutamic Acid / Q000009:adverse effects*; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D018698:Glutamic Acid; D004399:Dynorphins