title: Multiple functions of the S-phase checkpoint mediator.
abstract: There is mounting evidence that replication defects are the major source of spontaneous genomic instability in cells, and that S-phase checkpoints are the principal defense against such instability. The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase. In this review, the multiple functions and the regulation of the S-phase checkpoint mediator are discussed.
authors.affiliation: Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan. katsunori@kwansei.ac.jp
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism*; D004261:DNA Replication; D004789:Enzyme Activation; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism; D055550:Protein Stability; D016196:S Phase
chemical_list: D018797:Cell Cycle Proteins; D011494:Protein Kinases