title: Differential expression of type 2 3α/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) in tumors of the central nervous system.
abstract: Human aldo-keto reductase (AKR) 1C3, type 2 3α-hydroxysteroid dehydrogenase (HSC)/ type 5 17β-HSD, is known to be involved in steroids, prostaglandins, and lipid aldehydes metabolism. The expression of AKR1C3 has been demonstrated in hormone-dependent normal tissues such as breast, endometrium, prostate, and testis; and de -regulated AKR1C3 expression has been shown in breast carcinoma, endometrial hyperplasia, endometrial carcinoma, and prostate carcinoma. AKR1C3 expression has also been demonstrated in hormone-independent normal tissues (renal tubules and urothelium) and neoplastic tissues (renal cell carcinoma, Wilm's tumor, and urothelial cell carcinoma). Extensive expression of AKR1C3 in normal and neoplastic as well as hormone-dependent and hormone-independent tissues indicates that AKR1C3 may have functions beyond steroid hormone metabolism. In this report, we describe a widespread expression of AKR1C3 in glial neoplasms and meningiomas, with limited expression in medulloblastoma and no expression in Schwannoma. These tumors, except meningioma, are not classically considered to be sex hormone-dependent or related brain tumors. The current results corroborate our earlier observations that AKR1C3 is expressed in both sex hormone-dependent and hormone-independent malignancies. Similar to AKR1C3 distribution in Wilm's tumor, we also demonstrate that expression of AKR1C3 is reduced in tumors with embryonic phenotypes.
authors.affiliation: College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Aubrey L
authors.initials: AL
authors.lastname: Park
authors.forename: Hsueh-Kung
authors.initials: HK
authors.lastname: Lin
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Chor Wing
authors.initials: CW
authors.lastname: Sing
authors.forename: Michael
authors.initials: M
authors.lastname: Fan
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Mapstone
authors.forename: Naina L
authors.initials: NL
authors.lastname: Gross
authors.forename: Mary K
authors.initials: MK
authors.lastname: Gumerlock
authors.forename: Michael D
authors.initials: MD
authors.lastname: Martin
authors.forename: Craig H
authors.initials: CH
authors.lastname: Rabb
authors.forename: Kar-Ming
authors.initials: KM
authors.lastname: Fung
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000074425:Aldo-Keto Reductase Family 1 Member C3; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D005910:Glioma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism*; D007150:Immunohistochemistry; D008527:Medulloblastoma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D009442:Neurilemmoma / Q000201:enzymology* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D015096:3-Hydroxysteroid Dehydrogenases; D006911:Hydroxyprostaglandin Dehydrogenases; C487341:AKR1C3 protein, human; D000074425:Aldo-Keto Reductase Family 1 Member C3