title: A novel cationic triazatetrabenzcorrole: selective detection of mercury(II) by nucleic acid-induced aggregation.
abstract: In the present work, a novel water-soluble cationic triazatetrabenzcorrole compound was synthesised. Its aggregation and fluorescence quenching properties are demonstrated by serval methods, such as UV-vis and fluorescence spectroscopic studies and naked-eye visualization. Unlike the traditional Hg(2+) sensor based on thymine-Hg(2+)-thymine, we use a novel approach, exploiting the high affinity of Hg(2+) for sulfur in phosphorothioate DNA. Based on the S-Hg(2+)-S pairs, we designed the phosphorothioate DNA T4G4-S3 as an Hg(2+) sensor, which can detect Hg(2+) sensitively and selectively in aqueous solution. And this sensing system is fairly fast and convenient.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan, 430072, P. R. of China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Minggang
authors.initials: M
authors.lastname: Deng
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Du
authors.forename: Shengyong
authors.initials: S
authors.lastname: Yan
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Weng
authors.forename: Chuluo
authors.initials: C
authors.lastname: Yang
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002412:Cations; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D008628:Mercury / Q000032:analysis* / Q000737:chemistry; D054735:Phosphorothioate Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013455:Sulfur / Q000737:chemistry / Q000378:metabolism; D013941:Thymine / Q000737:chemistry
chemical_list: D002412:Cations; D005456:Fluorescent Dyes; D054735:Phosphorothioate Oligonucleotides; D011166:Porphyrins; D012996:Solutions; C431863:corrole; C558267:triazatetrabenzcorrole; D013455:Sulfur; D004247:DNA; D008628:Mercury; D013941:Thymine