title: Water-soluble peptide-coated nanoparticles: control of the helix structure and enhanced differential binding to immune cells.
abstract: The stabilizing action of C(α)-tetrasubstituted α-amino acids inserted into a sequence of short peptides allowed for the first time the preparation of water-soluble nanoparticles of different materials coated with a helix-structured undecapeptide. This peptide coating strongly favors nanoparticle uptake by human immune system cells.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Padova, via Marzolo 1, 35131 Padova, Italy.
authors.forename: Iria M
authors.initials: IM
authors.lastname: Rio-Echevarria
authors.forename: Regina
authors.initials: R
authors.lastname: Tavano
authors.forename: Valerio
authors.initials: V
authors.lastname: Causin
authors.forename: Emanuele
authors.initials: E
authors.lastname: Papini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Mancin
authors.forename: Alessandro
authors.initials: A
authors.lastname: Moretto
mesh_terms: D006367:HeLa Cells; D006801:Humans; D007107:Immune System / Q000166:cytology*; D008264:Macrophages / Q000378:metabolism; D008958:Models, Molecular; D009000:Monocytes / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D017433:Protein Structure, Secondary; D012833:Siloxanes / Q000737:chemistry; D012995:Solubility; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry*
chemical_list: D010455:Peptides; D012833:Siloxanes; C510784:ormosil; D014867:Water