title: [The effect of aldosterone of promotion on proliferation of ventricular fibroblasts].
abstract: OBJECTIVE
  To study the effect of promoting aldosterone on proliferation of ventricular fibroblasts.
  
  
  METHODS
  Assay of [3H]-TdR incorporation rate and RT-PCR were used.
  
  
  RESULTS
  Aldosterone could promote [3H]-TdR incorporation of ventricular fibroblasts, the effective dose of aldosterone was among (1 x 10(-9)-1 x 10(-6))mol/L, and had dose-dependent manner, the c-fos gene was expressed after stimulated by aldosterone for 15 min, and studied the highest in 1 h, then reduced later. Spironolactone, aldosterone receptor antagonist could block the effect of aldosterone.
  
  
  CONCLUSIONS
  Aldosterone promotes the proliferation of ventricular fibroblasts, mediated by aldosterone receptor.
authors.affiliation: Department of Physiology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Gong
authors.forename: P Q
authors.initials: PQ
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: Lu
authors.forename: Z
authors.initials: Z
authors.lastname: Tan
authors.forename: S G
authors.initials: SG
authors.lastname: Fu
authors.forename: J Y
authors.initials: JY
authors.lastname: Pan
mesh_terms: D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects*; D006352:Heart Ventricles / Q000166:cytology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000450:Aldosterone