title: Designing tyrosine-derived polycarbonate polymers for biodegradable regenerative type neural interface capable of neural recording.
abstract: Next-generation neuroprosthetic limbs will require a reliable long-term neural interface to residual nerves in the peripheral nervous system (PNS). To this end, we have developed novel biocompatible materials and a fabrication technique to create high site-count microelectrodes for stimulating and recording from regenerated peripheral nerves. Our electrodes are based on a biodegradable tyrosine-derived polycarbonate polymer system with suitable degradation and erosion properties and a fabrication technique for deployment of the polymer in a porous, degradable, regenerative, multiluminal, multielectrode conduit. The in vitro properties of the polymer and the electrode were tuned to retain mechanical strength for over 24 days and to completely degrade and erode within 220 days. The fabrication technique resulted in a multiluminal conduit with at least 10 functioning electrodes maintaining recording site impedance in the single-digit kOhm range. Additionally, in vivo results showed that neural signals could be recorded from these devices starting at four weeks postimplantation and that signal strength increased over time. We conclude that our biodegradable regenerative-type neural interface is a good candidate for chronic high fidelity recording electrodes for integration with regenerated peripheral nerves.
authors.affiliation: New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, 08854, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Lewitus
authors.forename: R Jacob
authors.initials: RJ
authors.lastname: Vogelstein
authors.forename: Gehua
authors.initials: G
authors.lastname: Zhen
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Choi
authors.forename: Joachim
authors.initials: J
authors.lastname: Kohn
authors.forename: Stuart
authors.initials: S
authors.lastname: Harshbarger
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Jia
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D017097:Electric Impedance; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation; D055595:Mechanical Phenomena; D008839:Microelectrodes; D008970:Molecular Weight; D009482:Neurophysiology; D011076:Polycarboxylate Cement / Q000737:chemistry*; D011108:Polymers; D019736:Prostheses and Implants; D011474:Prosthesis Design / Q000379:methods*; D011817:Rabbits; D012815:Signal Processing, Computer-Assisted; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011076:Polycarboxylate Cement; D011108:Polymers; C005506:polycarbonate; D014443:Tyrosine