title: Effectiveness of the homeopathic preparation Zeel compared with carprofen in dogs with osteoarthritis.
abstract: The authors compared the symptomatic effectiveness of a complex homeopathic preparation Zeel (1-3 tablets orally per day depending on body weight) to carprofen (4 mg/kg body weight) in dogs (n=68) aged >1 yr diagnosed with osteoarthritis in a multicenter, prospective, observational open-label cohort study in 12 German veterinary clinics. The active treatment period was 56 days. Symptomatic effectiveness, lameness, stiffness of movements, and pain on palpation were evaluated by treating veterinarians and owners. Clinical signs of osteoarthritis improved significantly (P<0.05) at all time points (days 1, 28, and 56) with both therapies. At the end of the treatment period, effectiveness was comparable in both groups. Both treatment regimens were well tolerated with only three treatment-related adverse events, all in the carprofen group.
authors.affiliation: Clinic for Small Animals, Institute of Veterinary Medicine, University of Goettingen, Germany. sneuman@gwdg.de
authors.forename: Stephan
authors.initials: S
authors.lastname: Neumann
authors.forename: Pelle
authors.initials: P
authors.lastname: Stolt
authors.forename: Gabriele
authors.initials: G
authors.lastname: Braun
authors.forename: Klaus
authors.initials: K
authors.lastname: Hellmann
authors.forename: Erich
authors.initials: E
authors.lastname: Reinhart
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D015331:Cohort Studies; D000529:Complementary Therapies / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000628:therapy*; D004285:Dogs; D005260:Female; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy / Q000628:therapy / Q000662:veterinary*; D010936:Plant Extracts / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D010936:Plant Extracts; C007005:carprofen