title: Cross-domain neurobiology data integration and exploration.
abstract: BACKGROUND
  Understanding the biomedical implications of data from high throughput experiments requires solutions for effective cross-scale and cross-domain data exploration. However, existing solutions do not provide sufficient support for linking molecular level data to neuroanatomical structures, which is critical for understanding high level neurobiological functions.
  
  
  RESULTS
  Our work integrates molecular level data with high level biological functions and we present results using anatomical structure as a scaffold. Our solution also allows the sharing of intermediate data exploration results with other web applications, greatly increasing the power of cross-domain data exploration and mining.
  
  
  CONCLUSIONS
  The Flex-based PubAnatomy web application we developed enables highly interactive visual exploration of literature and experimental data for understanding the relationships between molecular level changes, pathways, brain circuits and pathophysiological processes. The prototype of PubAnatomy is freely accessible at: [http://brainarray.mbni.med.umich.edu/Brainarray/prototype/PubAnatomy].
authors.affiliation: Psychiatry Department and Molecular and Behavioral Neuroscience Institute, University of Michigan, USA. wxuan@umich.edu
authors.forename: Weijian
authors.initials: W
authors.lastname: Xuan
authors.forename: Manhong
authors.initials: M
authors.lastname: Dai
authors.forename: Josh
authors.initials: J
authors.lastname: Buckner
authors.forename: Barbara
authors.initials: B
authors.lastname: Mirel
authors.forename: Jean
authors.initials: J
authors.lastname: Song
authors.forename: Brian
authors.initials: B
authors.lastname: Athey
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Watson
authors.forename: Fan
authors.initials: F
authors.lastname: Meng
mesh_terms: D057225:Data Mining / Q000379:methods*; D003628:Database Management Systems; D016208:Databases, Factual; D053263:Gene Regulatory Networks; D020407:Internet; D016239:MEDLINE; D008959:Models, Neurological; D014584:User-Computer Interface