title: Antibiotic prophylaxis for patients undergoing elective laparoscopic cholecystectomy.
abstract: BACKGROUND
  Cholecystectomy is a common surgical procedure. In the open cholecystectomy area, antibiotic prophylaxis showed beneficial effects, but it is not known if its benefits and harms are similar in laparoscopic cholecystectomy. Some clinical trials suggest that antibiotic prophylaxis may not be necessary in laparoscopic cholecystectomy.
  
  
  OBJECTIVE
  To assess the beneficial and harmful effects of antibiotic prophylaxis versus placebo or no prophylaxis for patients undergoing elective laparoscopic cholecystectomy.
  
  
  METHODS
  We searched the The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library (Issue 3, 2010), MEDLINE (1985 to August 2010), EMBASE (1985 to August 2010), SCI-EXPANDED (1985 to August 2010), LILACS (1988 to August 2010) as well as reference lists of relevant articles.
  
  
  METHODS
  Randomised clinical trials comparing antibiotic prophylaxis versus placebo or no prophylaxis in patients undergoing elective laparoscopic cholecystectomy.
  
  
  METHODS
  Our outcome measures were all-cause mortality, surgical site infections, extra-abdominal infections, adverse events, and quality of life. All outcome measures were confined to within hospitalisation or 30 days after discharge. We summarised the outcome measures by reporting odds ratios and 95% confidence intervals (CI), using both the fixed-effect and the random-effects models.
  
  
  RESULTS
  We included eleven randomised clinical trials with 1664 participants who were mostly at low anaesthetic risk, low frequency of co-morbidities, low risk of conversion to open surgery, and low risk of infectious complications. None of the trials had low risk of bias. We found no statistically significant differences between antibiotic prophylaxis and no prophylaxis in the proportion of surgical site infections (odds ratio (OR) 0.87, 95% CI 0.49 to 1.54) or extra-abdominal infections (OR 0.77, 95% CI 0.41 to 1.46). Heterogeneity was not statistically significant.
  
  
  CONCLUSIONS
  This systematic review shows that there is not sufficient evidence to support or refute the use of antibiotic prophylaxis to reduce surgical site infection and global infections in patients with low risk of anaesthetic complications, co-morbidities, conversion to open surgery, and infectious complications, and undergoing elective laparoscopic cholecystectomy. Larger randomised clinical trials with intention-to-treat analysis and patients also at high risk of conversion to open surgery are needed.
authors.affiliation: Department of Surgery, School of Medicine-Universidad de La Sabana, Fundación Abood Shaio, Campus Puente del Comun km 21 via Chia, Chia, Cundinamarca, Colombia.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Sanabria
authors.forename: Luis C
authors.initials: LC
authors.lastname: Dominguez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Valdivieso
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gomez
mesh_terms: D019072:Antibiotic Prophylaxis / Q000009:adverse effects / Q000379:methods*; D001424:Bacterial Infections / Q000517:prevention & control; D017081:Cholecystectomy, Laparoscopic; D017558:Elective Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013530:Surgical Wound Infection / Q000517:prevention & control*