title: [Study on the cytotoxicity induced by ceramic alloys].
abstract: OBJECTIVE
  To investigate the cytotoxicity of 3 kinds of dental ceramic alloys.
  
  
  METHODS
  Methods of 4-methyl-thiazolyl tetrazolium assay (MTT) and single cell gel electrophoresis (comet assay) were used to detect the influence on mouse fibroblast L929 relative growth rate (relative growth rate, RGR) and damage of DNA induced by three kinds of ceramic alloys.
  
  
  RESULTS
  RGR of the golden alloy group was 87.7 ± 11.3 which showed no significant difference when compared with the cobalt-chromium alloy group and the control group, while among other groups, there were statistically significant differences in RGR (P<0.05); the rank of DNA damage of nickel-chromium alloy was severe, while the ranks of cobalt-chromium alloy and golden alloy group were moderate and mild respectively.
  
  
  CONCLUSIONS
  The influence of golden alloy and cobalt-chromium alloy on RGR is significantly lower than nickel-chromium alloy, meanwhile the damage of DNA caused by golden alloy is lightest, so it is a kind of dental ceramic alloy with good biocompatibility.
authors.affiliation: Department of Prosthodontics, Affiliated Dental Hospital, Zunyi Medical College, Zunyi, China. zhangyong0852@126.com
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yong
authors.forename: Wei
authors.initials: W
authors.lastname: Ji-ying
mesh_terms: D000497:Alloys / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D002516:Ceramics / Q000633:toxicity*; D002858:Chromium Alloys / Q000633:toxicity; D003722:Dental Alloys / Q000633:toxicity*; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D051379:Mice
chemical_list: D000497:Alloys; D002858:Chromium Alloys; D003722:Dental Alloys