title: Sparse reconstruction for quantitative bioluminescence tomography based on the incomplete variables truncated conjugate gradient method.
abstract: In this paper, we present an incomplete variables truncated conjugate gradient (IVTCG) method for bioluminescence tomography (BLT). Considering the sparse characteristic of the light source and insufficient surface measurement in the BLT scenarios, we combine a sparseness-inducing (ℓ1 norm) regularization term with a quadratic error term in the IVTCG-based framework for solving the inverse problem. By limiting the number of variables updated at each iterative and combining a variable splitting strategy to find the search direction more efficiently, it obtains fast and stable source reconstruction, even without a priori information of the permissible source region and multispectral measurements. Numerical experiments on a mouse atlas validate the effectiveness of the method. In vivo mouse experimental results further indicate its potential for a practical BLT system.
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an 710071, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: He
authors.forename: Jimin
authors.initials: J
authors.lastname: Liang
authors.forename: Xiaorui
authors.initials: X
authors.lastname: Wang
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yu
authors.forename: Xiaochao
authors.initials: X
authors.lastname: Qu
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Hou
authors.forename: Duofang
authors.initials: D
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008163:Luminescent Measurements / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D009928:Organ Specificity; D041622:Tomography, Optical / Q000379:methods*; D055114:X-Ray Microtomography