title: Perspectives for tailored chemoprevention and treatment of colorectal cancer in Lynch syndrome.
abstract: Lynch syndrome (LS) is caused by a germline mutation in one of the mismatch repair (MMR) genes. The resulting loss of MMR gene function induces a strong mutator phenotype and predisposition to colorectal cancer (CRC). LS mutation carriers undergo regular colonoscopic surveillance and have extensive colonic resection in case of cancer because of the chance of metachronous tumors. Given the high risk and early onset of CRC, LS mutation carriers are good candidates for chemoprevention. Furthermore, evidence increases indicating that the response of MMR-deficient tumors to standard chemotherapy and radiotherapy differs from that of MMR-proficient tumors. Efforts should thus be directed at designing tailored strategies concerning both chemoprevention and medical cancer treatment for LS individuals. This review provides guidance for future studies in this field based on results from clinical and preclinical research.
authors.affiliation: Department of Medical Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Dianne M
authors.initials: DM
authors.lastname: Heijink
authors.forename: Elisabeth G E
authors.initials: EG
authors.lastname: de Vries
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Koornstra
authors.forename: Geke A P
authors.initials: GA
authors.lastname: Hospers
authors.forename: Robert M W
authors.initials: RM
authors.lastname: Hofstra
authors.forename: Marcel A T M
authors.initials: MA
authors.lastname: van Vugt
authors.forename: Steven
authors.initials: S
authors.lastname: de Jong
authors.forename: Jan H
authors.initials: JH
authors.lastname: Kleibeuker
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control* / Q000532:radiotherapy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control* / Q000532:radiotherapy; D006801:Humans; D009154:Mutation / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents