title: Hyperadiponectinemia is independent of kidney function, diabetes duration, and control in type 1 diabetic patients without microangiopathy.
abstract: BACKGROUND
  High total adiponectin (ADPN) levels were reported in type 1 diabetes (T1D) and related to long diabetes duration and nephropathy. We studied whether ADPN and its specific isoforms were elevated in T1D without microangiopathy and whether they were related to kidney function.
  
  
  METHODS
  Total, high, medium, and low molecular weight ADPN and insulin levels were measured in 47 consecutive normoalbuminuric, normotensive T1D patients without retinopathy and in 47 age-, sex-, and body mass index-matched controls. Glomerular filtration rate was estimated by (51)Cr-EDTA plasma clearance.
  
  
  RESULTS
  Total and high molecular weight ADPN ratio were higher in T1D patients than in controls. ADPN levels were not related to anthropometric measures, whereas they were in controls. In T1D, ADPN levels were not related to glycosylated hemoglobin, diabetes duration, or glomerular filtration rate. Peripheral insulin levels were higher in T1D patients than in controls, but they were not related to ADPN levels. In controls, insulin levels were positively related to total ADPN.
  
  
  CONCLUSIONS
  In T1D without microangiopathy, high ADPN levels could not be related to anthropometric diabetes parameters, kidney function, or high insulin levels. The nature of this elevation remains unknown.
authors.affiliation: Service de Diabétologie Endocrinologie Nutrition, Hôpital Bichat, Assistance Publique des Hôpitaux de Paris, 75877 Paris, France.
authors.forename: Charbel
authors.initials: C
authors.lastname: Abi Khalil
authors.forename: Kamel
authors.initials: K
authors.lastname: Mohammedi
authors.forename: Roberte
authors.initials: R
authors.lastname: Aubert
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Abou Jaoude
authors.forename: Florence
authors.initials: F
authors.lastname: Travert
authors.forename: Samy
authors.initials: S
authors.lastname: Hadjadj
authors.forename: Frédéric
authors.initials: F
authors.lastname: Fumeron
authors.forename: Ronan
authors.initials: R
authors.lastname: Roussel
authors.forename: Michel
authors.initials: M
authors.lastname: Marre
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry; D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D008970:Molecular Weight; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin