title: A proposal for identifying the low renal uric acid clearance phenotype.
abstract: Investigation of the genetic basis of hyperuricaemia is a subject of intense interest. However, clinical studies commonly include hyperuricaemic patients without distinguishing between 'over-producers' or 'under-excretors' of urate. The statistical power of studies of genetic polymorphisms of genes encoding renal urate transporters is diluted if 'over-producers' of uric acid are included. We propose that lower than normal fractional renal clearance of urate is a better inclusion criterion for these studies. We also propose that a single daytime spot urine sample for calculation of fractional renal clearance of urate should be preferred to calculation from 24-hour urine collections.
authors.affiliation: Faculty of Medicine, University of New South Wales, NSW, 2052, Australia.
authors.forename: Praveen L
authors.initials: PL
authors.lastname: Indraratna
authors.forename: Sophie L
authors.initials: SL
authors.lastname: Stocker
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Williams
authors.forename: Garry G
authors.initials: GG
authors.lastname: Graham
authors.forename: Graham
authors.initials: G
authors.lastname: Jones
authors.forename: Richard O
authors.initials: RO
authors.lastname: Day
mesh_terms: D006801:Humans; D033461:Hyperuricemia / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D007677:Kidney Function Tests / Q000379:methods*; D027361:Organic Anion Transporters / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D027361:Organic Anion Transporters; C103862:urate transporter; D014527:Uric Acid