title: Association of thyroglobulin gene variants with carcass and meat quality traits in beef cattle.
abstract: Thyroid hormones play an important role in regulating metabolism and can affect homeostasis of fat deposition. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. In the present study, we identified 6 novel SNPs at the 3' flanking region of the TG gene. The SNP marker association analysis indicated that the T354C, G392A, A430G and T433G SNP markers were significantly associated with marbling score (P < 0.05). Animals with the new homozygote genotype had higher marbling score than those with the other genotypes. Otherwise, the linkage disequilibrium analysis indicated that these four SNPs were completely linked (r (2) = 1). Results from this study suggest that TG gene-specific SNP may be a useful marker for meat quality traits in future marker assisted selection programs in beef cattle.
authors.affiliation: Institute of Tropical Crop Genetic Resources, Chinese Academy of Tropical Agricultural Sciences (CATAS), Danzhou Hainan 571737, China. guanyuhou@126.com
authors.forename: Guan-Yu
authors.initials: GY
authors.lastname: Hou
authors.forename: Zheng-Rong
authors.initials: ZR
authors.lastname: Yuan
authors.forename: Han-Lin
authors.initials: HL
authors.lastname: Zhou
authors.forename: Lu-Pei
authors.initials: LP
authors.lastname: Zhang
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.forename: Dong-Jing
authors.initials: DJ
authors.lastname: Wang
authors.forename: Hui-Jiang
authors.initials: HJ
authors.lastname: Gao
authors.forename: Shang-Zhong
authors.initials: SZ
authors.lastname: Xu
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D005819:Genetic Markers; D005838:Genotype; D008460:Meat / Q000592:standards*; D008969:Molecular Sequence Data; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D013954:Thyroglobulin / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D013954:Thyroglobulin