title: Immunological peculiarities of CD-56-positive serous ovarian adenocarcinoma.
abstract: Here we present the results of evaluation of the expression of neural cell adhesion molecules CD56 (NCAM) in serous ovarian adenocarcinoma. The expression was detected in 48.5% cases. Infiltration of tumor stroma and parenchyma with CD8+ and CD4+ lymphocytes was significantly less pronounced in tumors expressing neural cell adhesion molecules; CD3+CD4+CD25+ predominate among CD4+ lymphocytes in CD56+ tumors. CD56+ tumors were lower in size (5.2±0.6, 7.9±0.8 and 10.3±1.5 cm in monomorphic, mosaic, and negative phenotypes, respectively (p=0.05) and were characterized by the absence of cystic component (p=0.012), larger disseminations in the peritoneum (4.2±1.1 and 2.7±0.5 cm; p=0.05), and larger volume of the residual tumor (p=0.018) after surgical treatment. NCAM phenotype of the tumor does not correlate with the stage and differentiation degree of serous ovarian adenocarcinoma.
authors.affiliation: Laboratory of Hemopoiesis Immunology, Institute of Clinical Oncology, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. faccell@rambler.ru
authors.forename: E V
authors.initials: EV
authors.lastname: Zueva
authors.forename: M Z
authors.initials: MZ
authors.lastname: Kairbayeva
authors.forename: S O
authors.initials: SO
authors.lastname: Nikogosyan
authors.forename: A V
authors.initials: AV
authors.lastname: Mozhenkova
authors.forename: M A
authors.initials: MA
authors.lastname: Digaeva
authors.forename: I V
authors.initials: IV
authors.lastname: Tereshkina
authors.forename: N N
authors.initials: NN
authors.lastname: Tupitsyn
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D019002:CD56 Antigen / Q000096:biosynthesis / Q000276:immunology*; D000077216:Carcinoma, Ovarian Epithelial; D018284:Cystadenocarcinoma, Serous / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology; D010051:Ovarian Neoplasms / Q000276:immunology
chemical_list: D015703:Antigens, CD; D019002:CD56 Antigen; C522918:NCAM1 protein, human