title: Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates.
abstract: BACKGROUND
  T1- and T2-W MR sequences used for obtaining diagnostic information and morphometric measurements in the neonatal brain are frequently acquired using different imaging protocols. Optimizing one protocol for obtaining both kinds of information is valuable.
  
  
  OBJECTIVE
  To determine whether high-resolution T1- and T2-W volumetric sequences optimized for preterm brain imaging could provide both diagnostic and morphometric value.
  
  
  METHODS
  Thirty preterm neonates born between 24 and 32 weeks' gestational age were scanned during the first 2 weeks after birth. T1- and T2-W high-resolution sequences were optimized in terms of signal-to-noise ratio, contrast-to-noise ratio and scan time and compared to conventional spin-echo-based sequences.
  
  
  RESULTS
  No differences were found between conventional and high-resolution T1-W sequences for diagnostic confidence, image quality and motion artifacts. A preference for conventional over high-resolution T2-W sequences for image quality was observed. High-resolution T1 images provided better delineation of thalamic myelination and the superior temporal sulcus. No differences were found for detection of myelination and sulcation using conventional and high-resolution T2-W images.
  
  
  CONCLUSIONS
  High-resolution T1- and T2-W volumetric sequences can be used in clinical MRI in the very preterm brain to provide both diagnostic and morphometric information.
authors.affiliation: Department of Diagnostic Imaging, The Hospital for Sick Children, Neurosciences & Mental Health, Research Institute, 555 University Ave., Toronto, M5G 1X8, Canada. rmanor@phenogenomics.ca
authors.forename: Revital
authors.initials: R
authors.lastname: Nossin-Manor
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Chung
authors.forename: Drew
authors.initials: D
authors.lastname: Morris
authors.forename: João P
authors.initials: JP
authors.lastname: Soares-Fernandes
authors.forename: Bejoy
authors.initials: B
authors.lastname: Thomas
authors.forename: Hai-Ling M
authors.initials: HL
authors.lastname: Cheng
authors.forename: Hilary E A
authors.initials: HE
authors.lastname: Whyte
authors.forename: Margot J
authors.initials: MJ
authors.lastname: Taylor
authors.forename: John G
authors.initials: JG
authors.lastname: Sled
authors.forename: Manohar M
authors.initials: MM
authors.lastname: Shroff
mesh_terms: D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity