title: Exercise capacity in pediatric patients with inflammatory bowel disease.
abstract: OBJECTIVE
  To examine exercise capacity in youth with Crohn's disease (CD) and ulcerative colitis (UC).
  
  
  METHODS
  Eleven males and eight females with CD and six males and four females with UC participated. Patients performed standard exercise tests to assess peak power (PP) and mean power (MP) and peak aerobic mechanical power (W(peak)) and peak oxygen uptake (VO(2peak)). Fitness variables were compared with reference data and also correlated with relevant clinical outcomes.
  
  
  RESULTS
  Pediatric patients with inflammatory bowel disease had lower PP (∼90% of predicted), MP (∼88% of predicted), W(peak) (∼91% of predicted), and VO(2peak) (∼75% of predicted) compared with reference values. When patients with CD or UC were compared separately to reference values, W(peak) was significantly lower only in the CD group. No statistically significant correlations were found between any exercise variables and disease duration (r = 0.01 to 0.14, P = .47 to .95) or disease activity (r = -0.19 to -0.31, P = .11 to .38), measured by pediatric CD activity index or pediatric ulcerative colitis activity index. After controlling for chronological age, recent hemoglobin levels were significantly correlated with PP (r = 0.45, P = .049), MP (r = 0.63, P = .003), VO(2peak) (r = 0.62, P = .004), and W(peak) (r = 0.70, P = .001).
  
  
  CONCLUSIONS
  Pediatric patients with inflammatory bowel disease exhibit impaired aerobic and anaerobic exercise capacity compared with reference values.
authors.affiliation: Institute of Human Movement Sciences, University of Groningen, Groningen, The Netherlands.
authors.forename: Hilde E
authors.initials: HE
authors.lastname: Ploeger
authors.forename: Tim
authors.initials: T
authors.lastname: Takken
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Wilk
authors.forename: Robert M
authors.initials: RM
authors.lastname: Issenman
authors.forename: Ryan
authors.initials: R
authors.lastname: Sears
authors.forename: Soni
authors.initials: S
authors.lastname: Suri
authors.forename: Brian W
authors.initials: BW
authors.lastname: Timmons
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D010101:Oxygen Consumption; D011379:Prognosis; D012720:Severity of Illness Index