title: Studies on stabilities of some human chorionic gonadotropin complexes with β-emitting radionuclides.
abstract: Human chorionic gonadotropin (hCG) is a peptide hormone, whose one of the structural subunits is identical to that of thyroid-stimulating hormone (TSH). As a consequence, the receptors of TSH also act as receptor for hCG hormone. Keeping in mind this interesting property of hCG we have studied the complex formation ability of various no-carrier-added β-emitting isotopes of (61)Cu (3.3 h), (62)Zn (9.2 h), (90)Nb (14.60 h) and (99)Mo (66.02 h) with hCG molecule. Stability of the hCG-M (M=metal ions) complexes was investigated by dialysis with respect to triple distilled water and ringer lactate solution, which has the same composition as extracellular fluid.
authors.affiliation: Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Moumita
authors.initials: M
authors.lastname: Maiti
authors.forename: Kamalika
authors.initials: K
authors.lastname: Sen
authors.forename: Souvik
authors.initials: S
authors.lastname: Sen
authors.forename: Susanta
authors.initials: S
authors.lastname: Lahiri
mesh_terms: D006063:Chorionic Gonadotropin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003301:Copper Radioisotopes / Q000737:chemistry*; D004355:Drug Stability; D006044:Goiter, Nodular / Q000532:radiotherapy; D006801:Humans; D007552:Isotonic Solutions / Q000737:chemistry; D008982:Molybdenum / Q000737:chemistry; D009556:Niobium / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011989:Receptors, Thyrotropin / Q000378:metabolism*; D000077325:Ringer's Lactate; D015037:Zinc Radioisotopes / Q000737:chemistry*
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003301:Copper Radioisotopes; D007552:Isotonic Solutions; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D011989:Receptors, Thyrotropin; D000077325:Ringer's Lactate; D015037:Zinc Radioisotopes; D009556:Niobium; D008982:Molybdenum