title: CD200 (OX-2 membrane glycoprotein) is expressed by follicular T helper cells and in angioimmunoblastic T-cell lymphoma.
abstract: CD200, an immunoglobulin superfamily membrane glycoprotein, is expressed in B cells, a subset of T cells, and in a range of B-cell lymphoproliferative disorders. We recently found, by immunohistochemical staining, that follicular helper T cells associated with neoplastic L and H cells in nodular lymphocyte predominant Hodgkin lymphoma, express CD200. Here we show that CD200 is expressed by follicular helper T cells in reactive lymphoid tissue, using single-color and 2-color immunohistochemical staining. Immunohistochemical staining of a range of T-cell lymphoproliferative disorders shows that the neoplastic cells in angioimmunoblastic T-cell lymphoma are immunoreactive for CD200, and the pattern of expression is similar to that of other follicular helper T-cell markers, PD-1 and CXCL13. In contrast, only a minority of cases of T-cell neoplasms other than angioimmunoblastic T-cell lymphoma are immunoreactive for CD200. A subset of CD200-positive peripheral T-cell lymphoma, not otherwise specified, cases may represent evolving angioimmunoblastic T-cell lymphoma or another neoplasm derived from follicular T helper cells. We conclude that CD200 is a useful immunophenotypic marker of angioimmunoblastic T-cell lymphoma and may be a suitable therapeutic target for an anti-CD200 immunotherapy undergoing clinical trial.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. ddorfman@partners.org
authors.forename: David M
authors.initials: DM
authors.lastname: Dorfman
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Shahsafaei
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D014408:Biomarkers, Tumor; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000276:immunology* / Q000473:pathology; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008221:Lymphoid Tissue / Q000276:immunology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000276:immunology* / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C042739:antigens, CD200