title: [Effects of noninvasive limb ischemic preconditioning on anti-stress ability in mice].
abstract: OBJECTIVE
  To explore the effects of noninvasive limb ischemic preconditioning on the anti-stress ability in mice.
  
  
  METHODS
  Mice were divided into: normal group, control group, preconditioning group and drug group. Hypoxia tolerance test, swimming with weight loading, cold tolerance test and thermostable test were performed, and tolerance time in all the stringent state were observed. SOD activity of serum in hypoxia tolerance test and lactic acid of serum in swimming with weight loading test were determined.
  
  
  RESULTS
  The time of hypoxia tolerance in preconditioning group was markedly increased, and SOD activity of preconditioning group mice was significantly higher than those of control group, while they were both shorter than drug group. The average time of swimming in preconditioning group was markedly increased and the level of increasing the swimming time of preconditioning was the same as caffeine. Preconditioning could increase the survival time on high temperature markedly, and there was no significantly difference in the level of increasing the survival time between preconditioning group and chlorpromazine group. Preconditioning could increase the time of cold tolerance markedly compared with normal group.
  
  
  CONCLUSIONS
  Noninvasive limb ischemic preconditioning can improve the ability of anti-hypoxia, anti-fatigue, thermoresistance and cold-resistance in mice.
authors.affiliation: Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Peng
authors.forename: Shu-juan
authors.initials: SJ
authors.lastname: Li
authors.forename: Yan-na
authors.initials: YN
authors.lastname: Wu
authors.forename: Jian-jie
authors.initials: JJ
authors.lastname: Jiao
authors.forename: Yan-xia
authors.initials: YX
authors.lastname: Liu
authors.forename: Jian-shi
authors.initials: JS
authors.lastname: Lou
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D005121:Extremities / Q000098:blood supply*; D005221:Fatigue / Q000517:prevention & control; D005260:Female; D000860:Hypoxia / Q000517:prevention & control*; D019194:Ischemic Preconditioning / Q000379:methods*; D008297:Male; D051379:Mice; D013312:Stress, Physiological / Q000502:physiology*