title: Management of patients hospitalized for diabetic foot infection: results of the French OPIDIA study.
abstract: OBJECTIVE
  This study was an analysis of how diabetic patients with infected foot wounds are managed in hospital by departments specializing in diabetic foot pathology, including an evaluation of the outcome 1 year after discharge.
  
  
  METHODS
  This was a prospective study of a cohort of patients hospitalized for diabetic foot infection at 38 hospital centres in France and followed-up for 1 year after discharge.
  
  
  RESULTS
  Altogether, 291 patients were included (73% male; 85% type 2 diabetes; mean age: 64.3±11.7 years). Most of the wounds were located on the toes and forefoot, and infection was most often graded as moderate; nevertheless, in about 50% of patients, osteomyelitis was suspected. Also, 87% of patients had peripheral neuropathy and 50-62% had peripheral artery disease. Gram-positive cocci, and Staphylococcus aureus in particular, were by far the most frequently isolated microorganisms. During hospitalization, lower-limb amputation was performed in 35% of patients; in 52%, the wound healed or had a favourable outcome. A year after discharge, 150 non-amputated patients were examined: at this time, 19% had to undergo amputation, whereas 79% had healed their wounds with no relapse. Risk factors for amputation were location (toes), severity of the wound and presence of osteomyelitis. Peripheral artery disease was associated with a poor prognosis, yet was very often neglected.
  
  
  CONCLUSIONS
  In spite of being managed at specialized centres that were, in general, following the agreed-upon published guidelines, the prognosis for diabetic foot infection remains poor, with a high rate (48%) of lower-limb amputation.
authors.affiliation: Department of Diabetology and Nutritional Diseases, Carémeau University Hospital, place du Professeur-Robert-Debré, 30029 Nîmes cedex 9, France. jean.louis.richard@chu-nimes.fr
authors.forename: J-L
authors.initials: JL
authors.lastname: Richard
authors.forename: J-P
authors.initials: JP
authors.lastname: Lavigne
authors.forename: I
authors.initials: I
authors.lastname: Got
authors.forename: A
authors.initials: A
authors.lastname: Hartemann
authors.forename: D
authors.initials: D
authors.lastname: Malgrange
authors.forename: D
authors.initials: D
authors.lastname: Tsirtsikolou
authors.forename: A
authors.initials: A
authors.lastname: Baleydier
authors.forename: E
authors.initials: E
authors.lastname: Senneville
mesh_terms: D000368:Aged; D017719:Diabetic Foot / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome