title: DNA microarray analysis of the liver of mice treated with cobalt chloride.
abstract: To investigate the in vivo effects of cobalt chloride on gene expression at early time points, DNA microarray analysis was performed on the liver of mice injected subcutaneously with cobalt chloride. The liver tissue samples were taken 0.5, 1, and 3 hr after injection. Of the 14 genes up-regulated at 0.5 hr after injection, 7 are related to immunological responses, and 4 of the 7 were found to be involved in the activation of interferon.
authors.affiliation: Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hitomi
authors.initials: H
authors.lastname: Fujishiro
authors.forename: Masahiko
authors.initials: M
authors.lastname: Satoh
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Himeno
mesh_terms: D000818:Animals; D003035:Cobalt / Q000633:toxicity*; D018076:DNA, Complementary / Q000235:genetics; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000235:genetics; D018075:RNA, Complementary / Q000235:genetics; D018675:Toxicity Tests
chemical_list: D018076:DNA, Complementary; D018075:RNA, Complementary; D003035:Cobalt; D012313:RNA; C018021:cobaltous chloride