title: Tetrabromobisphenol-A, hexabromocyclododecane and its degradation products in UK human milk: relationship to external exposure.
abstract: Tetrabromobisphenol-A (TBBP-A), hexabromocyclododecane (HBCD) and its degradation products were determined in 34 human milk samples from Birmingham, UK. TBBP-A was detected in 36% of samples (average=0.06 ng g(-1) lw), with HBCDs detected in all samples (average ΣHBCDs=5.95 ng g(-1) lw). α-HBCD comprised 62-95% ΣHBCDs while β- and γ-HBCD constituted 2-18% and 3-33% respectively. Enantioselective enrichment of (-)-α-HBCD (average enantiomer fraction=0.29) was observed indicating potential enantioselectivity associated with HBCD absorption, metabolism and/or excretion. The degradation products pentabromocyclododecenes (average=0.04 ng g(-1) lw; n=9) and tetrabromocyclododecadienes (average=0.15 ng g(-1) lw; n=25) were detected for the first time in human tissues. Average exposures of a nursing infant to ΣHBCDs and TBBP-A (35 and 1 ng kg(-1) bw day(-1) respectively) via breast milk exceeded upper-bound dietary intakes of both UK adults and toddlers. Using a simple pharmacokinetic model, intakes of UK adults via inhalation, diet and dust ingestion were converted to predicted body burdens. Predictions compared well with those observed for HBCDs but observed body burdens of TBBP-A exceeded predictions. This may indicate the human half-life of TBBP-A is greater than observed previously, that intakes may be underestimated, or that concentrations reported here reflect recent elevated episodic exposure.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt. mae_abdallah@yahoo.co.uk
authors.forename: Mohamed Abou-Elwafa
authors.initials: MA
authors.lastname: Abdallah
authors.forename: Stuart
authors.initials: S
authors.lastname: Harrad
mesh_terms: D001822:Body Burden; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis / Q000378:metabolism*; D004787:Environmental Pollution / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000032:analysis / Q000378:metabolism*; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D011075:Polybrominated Biphenyls / Q000032:analysis / Q000378:metabolism*; D006113:United Kingdom
chemical_list: D004785:Environmental Pollutants; D006842:Hydrocarbons, Brominated; D011075:Polybrominated Biphenyls; C089796:hexabromocyclododecane; C020806:tetrabromobisphenol A