title: Rickettsial infection with hemophagocytosis.
abstract: A five-year-old girl admitted with scrub typhus developed multiple organ dysfunction associated with hyperferritinaemia, hypofibrinogenaemia and hyperlipidaemia. Bone marrow aspiration studies confirmed haemophagocytic lymphohistiocytosis (HLH). HLH is a syndrome characterized by the uncontrolled activation and proliferation of macrophages and T-cells and can occur together with infections, connective tissue disorders, malignancies and genetic disorders.
authors.affiliation: Department of Paediatrics, Institute of Maternal and Child Health, Calicut Medical College, Calicut 8, Kerala 673 008, India. mp.jayakrishnan@gmail.com
authors.forename: M P
authors.initials: MP
authors.lastname: Jayakrishnan
authors.forename: John
authors.initials: J
authors.lastname: Veny
authors.forename: M
authors.initials: M
authors.lastname: Feroze
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009102:Multiple Organ Failure / Q000821:virology; D010198:Pancytopenia / Q000473:pathology; D011379:Prognosis; D012282:Rickettsia Infections / Q000150:complications*; D012612:Scrub Typhus / Q000150:complications*; D013577:Syndrome; D013601:T-Lymphocytes / Q000473:pathology / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D004318:Doxycycline