title: Plasma matrix metalloproteinase 9 correlates with disorders of brain magnesium homeostasis in patients undergoing coronary artery bypass surgery.
abstract: BACKGROUND
  Changes in plasma matrix metalloproteinase 9 (MMP-9) concentrations and parallel changes in brain magnesium homeostasis have not been examined in cardiac surgery patients. The purpose of the present study was to analyse these relationships in patients undergoing coronary artery bypass surgery (CABG) with extracorporeal circulation (ECC). Additionally, the effect of volatile anaesthetics was considered.
  
  
  METHODS
  Adult patients undergoing CABG with ECC under general anaesthesia were studied. Plasma MMP-9 and total (tMg) and ionized (iMg) magnesium concentrations were measured during surgery and during the early postoperative period. The plasma arteriovenous (a-v) tMg and iMg differences in the brain circulation were considered to be markers for brain magnesium homeostasis. The Mini-Mental State Examination test and computer tomography were used to diagnose postoperative neuropsychological disorders (PNPDs).
  
  
  RESULTS
  In total, 92 patients were examined. PNPDs were noted in 17 cases. Cardiac surgery resulted in increased plasma levels of MMP-9. The highest MMP-9 concentrations were observed in patients with PNPDs. MMP-9 concentrations strongly correlated with a-v tMg and a-v iMg differences. Compared with arterial measurements, venous tMg and iMg concentrations were higher during and immediately after surgery and lower during the early postoperative period. The most severe differences in a-v tMg and iMg were noted in patients with PNPDs.
  
  
  CONCLUSIONS
  1. Cardiac surgery resulted in an increase in plasma MMP-9 concentrations. 2. This increase in MMP-9 was significantly greater in patients with PNPDs. 3. The plasma MMP-9 concentration was correlated with disorders of brain Mg homeostasis.
authors.affiliation: Department of Anaesthesiology Intensive Therapy, Medical University of Lublin, Poland. w.dabrowski5@yahoo.com
authors.forename: Wojciech
authors.initials: W
authors.lastname: Dabrowski
authors.forename: Ziemowit
authors.initials: Z
authors.lastname: Rzecki
authors.forename: Marek
authors.initials: M
authors.lastname: Czajkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Pilat
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Biernacka
authors.forename: Edyta
authors.initials: E
authors.lastname: Kotlinska
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Pasternak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Stążka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sztanke
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sztanke
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged
chemical_list: D020780:Matrix Metalloproteinase 9; D008274:Magnesium