title: A biology-based dynamic approach for the reconciliation of acute and chronic toxicity tests: application to Daphnia magna.
abstract: There is the need to integrate existing toxicity data in a coherent framework for extending their domain of applicability as well as their extrapolation potential. This integration would also reduce time and cost-consuming aspects of these tests and reduce animal usage. In this work, based on data extracted from literature, we have assessed the advantages that a dynamic biology-toxicant fate coupled model for Daphnia magna could provide when assessing toxicity data, in particular, the possibility to obtain from short-term (acute) toxicity test long-term (chronic) toxicity values taking into account the inherent variability of D. magna populations and the multiple sources of data. The results show that this approach overcomes some of the limitations of existing toxicity tests and that the prediction errors are considerably reduced when compared with the factor from 2 to 5 obtained using acute-to-chronic ratios.
authors.affiliation: European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Systems Toxicology Unit, Ispra (VA), Italy. jose.zaldivar-comenges@jrc.ec.europa.eu
authors.forename: José-Manuel
authors.initials: JM
authors.lastname: Zaldívar
authors.forename: Joaquín
authors.initials: J
authors.lastname: Baraibar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D007631:Chlordecone / Q000633:toxicity; D003621:Daphnia / Q000187:drug effects*; D007700:Kinetics; D008670:Metals / Q000633:toxicity; D008954:Models, Biological; D053758:Nanoparticles / Q000633:toxicity; D011725:Pyridines / Q000633:toxicity; D023382:Toxicity Tests, Acute / Q000379:methods*; D036401:Toxicity Tests, Chronic / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000900:Anti-Bacterial Agents; D008670:Metals; D011725:Pyridines; D014874:Water Pollutants, Chemical; C023666:pyridine; D007631:Chlordecone