title: [Study on visual evoked related potentials in young adults of different COMT genotypes by using a numeric working memory task].
abstract: OBJECTIVE
  To explore the change of number working memory ability in healthy young adults, a continuous 3-back number working memory task were performed for an hour and 12 Blocks according to different COMT genotypes of young adults.
  
  
  METHODS
  18 different genotype subjects were chosen from 112 healthy young adults, P3 event-related potentials was utilized to observe the relationship between this COMT polymorphism and cortical physiology in a continuous working memory task.
  
  
  RESULTS
  Subjects bearing the Val/Val homozygote had significantly higher mean P3 amplitudes than Val/Met heterozygote (P < 0.01), however, no significant differences in comparison to Met/Met homozygote.
  
  
  CONCLUSIONS
  Val/Met Heterozygote subjects are associated with the poorest performance of working memory. There is a relationship between COMT genotype and P3 visual event-related potentials evoked from 3-back task.
authors.affiliation: Institute of Sports Medicine, Soochow University, Suzhou 215021, China.
authors.forename: Chun-lin
authors.initials: CL
authors.lastname: Yue
authors.forename: Xue-chuan
authors.initials: XC
authors.lastname: Sun
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Deng
mesh_terms: D000328:Adult; D001921:Brain / Q000201:enzymology* / Q000502:physiology; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D018913:Event-Related Potentials, P300 / Q000235:genetics*; D005074:Evoked Potentials, Visual / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D002394:Catechol O-Methyltransferase