title: The genetic epidemiology of obesity: a case study.
abstract: Obesity (OMIM #601665) is a disease where excessive stores of body fat impact negatively on health. The first law of thermodynamics dictates that energy cannot be created or destroyed so if energy is taken into the body, but not transformed to ATP for metabolic work or dissipated as heat, it will be stored as fat. Therefore, the ultimate cause of obesity is a long-term positive energy imbalance [energy intake (EI) exceeds energy expenditure (EE)]. Despite this simple explanation, there is no single reason why EI may exceed EE meaning that the proximate causes of obesity are multi-factorial in origin involving a complex interplay of genetic, behavioural, and environmental influences on metabolism, diet, and activity.
authors.affiliation: Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, UK. l.m.johnson@ucl.ac.uk
authors.forename: Laura M
authors.initials: LM
authors.lastname: Johnson
mesh_terms: D015992:Body Mass Index; D002874:Chromosome Mapping; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D017720:Molecular Epidemiology / Q000379:methods*; D009765:Obesity / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*