title: Squamous cell carcinoma arising in discoid lupus erythematosus lesions of the ears infected with human papillomavirus.
abstract: We describe a 51-year-old white man with discoid lupus erythematosus (DLE) of the head, neck, trunk, and upper extremities of more than 20 years' duration who developed rapidly progressive squamous cell carcinoma (SCC) of the bilateral ear helices. Human papillomavirus (HPV) was detected from excised specimens from the ears via tissue immunohistochemistry. Human papillomavirus infection of discoid lesions may be responsible for the rapid progression of SCC of this patient's bilateral ear helices.
authors.affiliation: Department of Dermatology, Veterans Administration Medical Center, University Dr C, Pittsburgh, PA 15240, USA.
authors.forename: Joanne K
authors.initials: JK
authors.lastname: Simpson
authors.forename: Rafael
authors.initials: R
authors.lastname: Medina-Flores
authors.forename: Jau-Shyong
authors.initials: JS
authors.lastname: Deng
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000821:virology; D004431:Ear, External / Q000473:pathology / Q000821:virology; D005500:Follow-Up Studies; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000150:complications*; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications*; D012878:Skin Neoplasms / Q000209:etiology* / Q000821:virology