title: Two new resorcinol derivatives with strong cytotoxicity from the roots of Ardisia brevicaulis Diels.
abstract: Two new resorcinol derivatives, 4-hydroxy-2-methoxy-6-[(8Z)-pentadec-8-en-1-yl]phenyl acetate (1) and 4-hydroxy-2-methoxy-6-pentadecylphenyl acetate (2), together with known compounds ardisiphenol D (3), 5-tridecylresorcinol (4), 5-pentadecylresorcinol (5), 5-[(8Z)-pentadec-8-en-1-yl]resorcinol (6), belamcandaquinones C and D (7 and 8, resp.), ardisicrenoside A, ardisiacrispin B, (22E)-24-ethyl-5α-cholesta-7,22-dien-3-one, and (22E)-24-ethyl-5α-cholesta-7,22-dien-3β-ol were isolated from the MeOH extract of the roots of Ardisia brevicaulis Diels. Their structures were determined by spectroscopic analysis including ESI- and EI-MS, and NMR data. Cytotoxicities of 1-4 against cell lines A549, MCF-7, and PANC-1 were tested in vitro by the MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method. Compounds 1-4 showed cytotoxic activity against all cell lines stronger than that of cisplatin against A549.
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing, P R China.
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Manyuan
authors.initials: M
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Yisong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
mesh_terms: D000085:Acetates / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000840:Anisoles / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D031644:Ardisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D012118:Resorcinols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C557092:4-hydroxy-2-methoxy-6-(pentadec-8-en-1-yl)phenyl acetate; C557093:4-hydroxy-2-methoxy-6-pentadecylphenyl acetate; D000085:Acetates; D000840:Anisoles; D000972:Antineoplastic Agents, Phytogenic; D012118:Resorcinols; C000596532:ardisiphenol D; C031389:resorcinol