title: Inhibitor of indoleamine-2,3-dioxygenase 1-methyl-D-tryptophan can stimulate the growth of immunogenic tumors.
abstract: We studied the effect of 1-methyl-D-tryptophan, an inhibitor of indoleamine-2,3-dioxygenase, on the growth of transplanted hepatocarcinoma-29 in C3HA mice. Hepatocarcinoma-29 transplanted into the thigh muscles undergoes immunological rejection in more than 50% non-syngeneic recipients. Chronic local administration of 1-methyl-D-tryptophan promotes progressive growth of the tumor in recipient mice leading to 100% animal death. The stimulating effect of 1-methyl-D-tryptophan on tumor growth is discussed.
authors.affiliation: Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
authors.forename: E D
authors.initials: ED
authors.lastname: Vasil'eva
authors.forename: V P
authors.initials: VP
authors.lastname: Nikolin
authors.forename: N A
authors.initials: NA
authors.lastname: Popova
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000503:physiopathology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D019042:Muscle Neoplasms / Q000503:physiopathology; D009368:Neoplasm Transplantation; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; C028129:tryptophan methyl ester; D014364:Tryptophan