title: [Effects of gypsum on the firing of pyrogen-treated thermosensitive neurons in PO/AH of cats].
abstract: OBJECTIVE
  To investigate the possible central mechanism of antipyretic effects of Chinese medicine gypsum.
  
  
  METHODS
  Gypsum was injected after the fever model was established. The firing rate of thermosensitive neurons in preoptic-anterior hypothalamus(PO/AH) region was recorded by using extracellular microelectrode technique.
  
  
  RESULTS
  The injection of pyrogen evoked decrease in firing rate of the warm-sensitive neurons and increase in the cold-sensitive neurons in the region of PO/AH; the changes of the firing rate of pyrogen- treated warm-sensitive and cold-sensitive neurons could be reversed by the injection of gypsum.
  
  
  CONCLUSIONS
  The result may suggest that antipyretic action of gypsum is mediated by its influences on the thermosensitivity neurons in the region of PO/AH.
authors.affiliation: Department of Physiology, China Medical University, Shenyang 110001, China. spring1216@163.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Xia
authors.initials: X
authors.lastname: Bai
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Sun
authors.forename: Yu-Huan
authors.initials: YH
authors.lastname: Wu
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Yang
mesh_terms: D000200:Action Potentials; D000818:Animals; D058633:Antipyretics / Q000494:pharmacology*; D002133:Calcium Sulfate / Q000494:pharmacology*; D002415:Cats; D005334:Fever / Q000503:physiopathology*; D007032:Hypothalamus, Anterior / Q000503:physiopathology*; D008297:Male; D008419:Materia Medica / Q000494:pharmacology; D009474:Neurons / Q000502:physiology*; D011301:Preoptic Area / Q000503:physiopathology; D011749:Pyrogens
chemical_list: D058633:Antipyretics; D008419:Materia Medica; D011749:Pyrogens; D002133:Calcium Sulfate