title: [Effects of pumpkin polysaccharides on blood glucose and blood lipids in diabetic rats].
abstract: OBJECTIVE
  To investigate the effects of pumpkin polysaccharides on blood glucose and lipids levels in diabetic rats.
  
  
  METHODS
  Diabetic rats induced by alloxan through intraperitoneal injection were randomly divided into three groups, diabetes, xiaoke pill and pumpkin polysaccharides group, according to weight and blood glucose level. And the normal control group was founded at the same time. The normal control group and diabetes group were lavaged with distilled water, other two groups were respectively lavaged with xiaoke pill or pumpkin polysaccharides. Weighed once a week, and analyzed fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, and free fatty acid level in serum after 4 weeks.
  
  
  RESULTS
  In diabetes group, weight and high density lipoprotein level decreased, and fasting blood glucose, total cholesterol, triglyceride, low density lipoprotein, and free fatty acid level in serum increased significantly. But, all of the indexes changed oppositely in xiaoke pill group and pumpkin polysaccharides group, and effects of pumpkin polysaccharides were better.
  
  
  CONCLUSIONS
  Pumpkin polysaccharides can increase the weight, decrease the blood glucose and lipids levels in diabetic rats, and have some good effects to diabetes and diabetes complications.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.forename: Zhi-qin
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Wen-kao
authors.initials: WK
authors.lastname: Nan
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Yi-yong
authors.initials: YY
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D028464:Cucurbita / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008055:Lipids; D011134:Polysaccharides