title: [The effect of Astragalus membranaceus (Fisch) bge. on lipid peroxidation and NO level of myocardium from rats with diabetic nephropathy].
abstract: OBJECTIVE
  To study the effect of astragalus membranaceus (Fisch) bge. on the lipid peroxidation and NO level of myocardium from rats with diabetic nephropathy.
  
  
  METHODS
  Male wistar rats were divided into five groups: (1) A normal control group, (2) Diabetes group, (3) Diabetic nephropathy group, (4) Diabetic nephropathy group complicated with acute renal function damage, (5) Astragalus membranaceus (Fisch) bge. treatment group. The activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), nitric oxide synthase (NOS) and content of malondialdehyde (MDA), nitric oxide (NO) was determined biochemically from myocardial homogenate among different groups.
  
  
  RESULTS
  The activity of GSH-Px, SOD decreased and the content of MDA, NO and NOS activity increased in each experimental group compared with control group, as was more obvious in diabetic nephropathy group with acute renal function damage, which astragalus membranaceus (Fisch) bge could improve.
  
  
  CONCLUSIONS
  Astragalus membranaceus (Fisch) bge. could protect the myocardium in diabetic nephropathy by inhibiting lipid peroxidation and decreasing the level of NO.
authors.affiliation: First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: G R
authors.initials: GR
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S Z
authors.initials: SZ
authors.lastname: Mao
authors.forename: J M
authors.initials: JM
authors.lastname: Li
authors.forename: C F
authors.initials: CF
authors.lastname: Zhen
mesh_terms: D000818:Animals; D027885:Astragalus propinquus; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase