title: Scale-free dynamics of somatic adaptability in immune system.
abstract: The long-time dynamics of somatic adaptability in immune system is simulated by a simple physical model defined in the shape space. The immune system described by the model exhibits a scale free behavior as is observed in living systems. The balance between the positive and negative feedbacks of the model leads to a robust immune system where the positive one corresponds to the formation of memory cells and the negative one to immunosuppression. Also the immunosenescence of the system is discussed based on the time-dependence of the epigenetic landscape of the adaptive immune cells in the shape space.
authors.affiliation: Department of Physics, Kyushu University, Fukuoka, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Saito
authors.forename: Osamu
authors.initials: O
authors.lastname: Narikiyo
mesh_terms: D016922:Cellular Senescence; D044127:Epigenesis, Genetic; D025461:Feedback, Physiological; D007107:Immune System / Q000502:physiology*; D007108:Immune Tolerance; D007156:Immunologic Memory; D008954:Models, Biological