title: Clinical review: Guyton--the role of mean circulatory filling pressure and right atrial pressure in controlling cardiac output.
abstract: Arthur Guyton's concepts of the determinative role of right heart filling in cardiac output continue to be controversial. This paper reviews his seminal experiments in detail and clarifies the often confusing concepts underpinning his model. One primary criticism of Guyton's model is that the parameters describing venous return had not been measured in a functioning cardiovascular system in humans. Thus, concerns have been expressed in regard to the ability of Guyton's simplistic model, with few parameters, to model the complex human circulation. Further concerns have been raised in regard to the artificial experimental preparations that Guyton used. Recently reported measurements in humans support Guyton's theoretical and animal work.
authors.affiliation: Critical Care Medicine, Vancouver General Hospital, ICU, JPPN, 2nd Floor, Room 2438, 899 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada. williamhenderson@shaw.ca
authors.forename: William R
authors.initials: WR
authors.lastname: Henderson
authors.forename: Donald E G
authors.initials: DE
authors.lastname: Griesdale
authors.forename: Keith R
authors.initials: KR
authors.lastname: Walley
authors.forename: A William
authors.initials: AW
authors.lastname: Sheel
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008955:Models, Cardiovascular; D010827:Physiology / Q000266:history*