title: Atypical dengue Fever in a splenectomized boy with glucose-6- phosphodehydrogenase deficiency and thalassemia intermedia.
abstract: The authors report the difficulties faced in diagnosing and managing dengue fever in a 16-year-old boy suffering from glucose-6-phosphodehydrogenase deficiency and thalassemia intermedia 2 months after splenectomy. Prolonged fever, hepatomegaly, decrease in hematocrit were observed. Negative blood cultures, normal procalcitonin and persistent fever despite broad-spectrum antibiotics decreased the possibility of bacterial sepsis. Platelet count decreased to 58,000/μL on the day of defervescence and dengue IgM serology was positive. The course of dengue fever can be very different if underlying thalassemia, splenectomy and/or G-6PD deficiency are present.
authors.affiliation: Pediatric Hematology Oncology and BMT Unit, Department of Pediatrics, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, 110060, India.
authors.forename: Veronique
authors.initials: V
authors.lastname: Dinand
authors.forename: Vera
authors.initials: V
authors.lastname: Metzler
authors.forename: Satya Prakash
authors.initials: SP
authors.lastname: Yadav
authors.forename: Anupam
authors.initials: A
authors.lastname: Sachdeva
mesh_terms: D000293:Adolescent; D003715:Dengue / Q000175:diagnosis*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D008297:Male; D013156:Splenectomy; D017086:beta-Thalassemia / Q000150:complications*