title: A possible role of plasma aldosterone in hypotension secondary to iron-deficiency anaemia combined with zinc deficiency in rats.
abstract: Patients with Fe-deficiency anaemia are often afflicted by hypotension. However, the mechanism of secondary hypotension in Fe-deficiency anaemia is unknown. To investigate the pathogenesis of secondary hypotension in Fe-deficiency anaemia, we examined the effects of Fe deprivation on plasma aldosterone concentration and blood pressure in rats. A total of forty 4-week-old male Sprague-Dawley rats were assigned into four treatment groups of ten each for the 4-week study: Fe-deficient group (FD), Zn-deficient group (ZD), Fe/Zn-deficient group (FZD) and control group (CON). At days 26 and 27, blood pressure was measured by the tail-cuff method. Plasma aldosterone concentration was determined by ELISA. The data were analysed by Tukey's multiple comparison test. Rats in the FZD had significantly lower mean blood pressure (P < 0·01) and diastolic blood pressures (P < 0·05) and plasma aldosterone concentration (P < 0·01) compared to the CON. These results suggest that blood pressure is decreased in Fe-deficiency anaemia combined with Zn deficiency partly due to decreased circulating aldosterone concentrations in addition to decreased haematocrit.
authors.affiliation: Department of Human Nutrition, Seitoku University Graduate School, 550 Iwase, Matsudo, Chiba 271-8555, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Konomi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yokoi
mesh_terms: D000450:Aldosterone / Q000097:blood*; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000150:complications*; D000818:Animals; D001794:Blood Pressure; D004797:Enzyme-Linked Immunosorbent Assay; D006400:Hematocrit; D007022:Hypotension / Q000097:blood* / Q000150:complications*; D000090463:Iron Deficiencies; D008024:Ligands; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D015032:Zinc / Q000097:blood* / Q000172:deficiency*
chemical_list: D008024:Ligands; D000450:Aldosterone; D015032:Zinc