title: [Clinical validation of minimally invasive evaluation of systolic function].
abstract: OBJECTIVE
  Pulse contour continuous cardiac output (PiCCO) monitoring by means of transpulmonary thermodilution provides 2 indices of systolic function: the cardiac function index and the global ejection fraction. Our aim was to compare these 2 PiCCO indices to the left-ventricular ejection fraction obtained by transthoracic echocardiography.
  
  
  METHODS
  This was a prospective clinical study of 35 adult patients in the critical care unit of a university hospital. Each patient provided his or her own control data. Patients with marked changes in regional segment contractility or nonsinus rhythm were excluded. We collected patient variables, reason for admission to the critical care unit, the Acute Physiology and Chronic Health Evaluation II score, the reason for hemodynamic monitoring, and the infusion of vasoactive drugs at the time of the procedure.
  
  
  RESULTS
  Statistically significant correlations were found between the left-ventricular ejection fraction and the global ejection fraction (r=0.79, P<.001) and the cardiac function index (r=0.66, P<.001). The mean (SD) difference between the left-ventricular ejection fraction and the global ejection fraction and the cardiac function index were 1.05% (10.2%) (range, 19.0% to 29.1%) and 0.001% (12.4%) (range, -24.3% to 24.3%), respectively. For predicting a left-ventricular ejection fraction of less than 40%, the area under the curve was 0.879 for the global ejection fraction and 0.805 for the cardiac function index of A global ejection fraction less than 13.5% and a cardiac function index less than 3.15 min(-1) predicted a left-ventricular ejection fraction less than 40% with sensitivities of 97% and 96% and specificities of 85% and 77%, respectively.
  
  
  CONCLUSIONS
  In patients without marked changes in regional segment contractility, the global ejection fraction and the cardiac function index calculated by the PiCCO monitor offer a reliable and simple way to assess left-ventricular systolic function. Low values for these indicators suggest the need for echocardiographic assessment of left- and right-ventricular function.
authors.affiliation: Hospital Clínico Universitario, Valencia.
authors.forename: F J
authors.initials: FJ
authors.lastname: Belda
authors.forename: G
authors.initials: G
authors.lastname: Aguilar
authors.forename: J L
authors.initials: JL
authors.lastname: Jover
authors.forename: C
authors.initials: C
authors.lastname: Ferrando
authors.forename: S
authors.initials: S
authors.lastname: Postigo
authors.forename: B
authors.initials: B
authors.lastname: Aznárez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002302:Cardiac Output; D003422:Critical Care / Q000379:methods*; D004452:Echocardiography; D005260:Female; D005336:Fiber Optic Technology / Q000295:instrumentation; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D010092:Oximetry / Q000295:instrumentation / Q000379:methods*; D011446:Prospective Studies; D011674:Pulse; D015203:Reproducibility of Results; D013318:Stroke Volume; D013599:Systole / Q000502:physiology*; D013815:Thermodilution / Q000295:instrumentation / Q000379:methods*