title: Sentinel lymph node dissection is technically feasible in older breast cancer patients.
abstract: BACKGROUND
  Previous studies suggested that sentinel lymph node (SLN) identification rates are lower in older breast cancer patients. This study was undertaken to compare identification rates in patients 70 years of age and older versus those younger than 70 years in a large cohort undergoing sentinel lymph node dissection (SLND).
  
  
  METHODS
  Patients undergoing SLND between August 1993 and December 2006 were identified and grouped by age. Clinicopathologic data and details regarding the procedure were reviewed.
  
  
  RESULTS
  Of the 3995 patients undergoing SLND, 3406 (85.3%) were under 70 years of age, and 589 (14.7%) were 70 years or older. Age was significantly associated with clinical stage (P = .001) and tumor grade (P < .0001). A greater proportion in the older group had clinical stage I disease (74.7% vs. 66.8%), and a lower proportion had grade 3 tumors (24.0% vs. 36.1%). There were no significant differences by age in the mapping method or site of injection. Overall SLN identification rate was 97.2% and did not differ significantly by age. The SLN was positive in 23.1% of younger patients and 18.2% of older patients (P = .01).
  
  
  CONCLUSIONS
  Sentinel lymph node dissection can be performed with high identification rates regardless of patient age. Breast cancer patients 70 years and older with clinically negative axillary lymph nodes should be offered SLND, as the presence of lymph node metastasis may alter adjuvant therapy recommendations.
authors.affiliation: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: Vicente
authors.initials: V
authors.lastname: Valero
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Kong
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Hunt
authors.forename: Min
authors.initials: M
authors.lastname: Yi
authors.forename: Rosa F
authors.initials: RF
authors.lastname: Hwang
authors.forename: Funda
authors.initials: F
authors.lastname: Meric-Bernstam
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bedrosian
authors.forename: Merrick I
authors.initials: MI
authors.lastname: Ross
authors.forename: Gildy V
authors.initials: GV
authors.lastname: Babiera
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Litton
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Mittendorf
mesh_terms: D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011446:Prospective Studies; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*