title: Immunohistochemical detection of olfactory-specific sensory transduction proteins in olfactory neuroblastoma.
abstract: Olfactory neuroblastoma (ONB) is a malignant tumor found in the superior nasal cavity. Although there is not adequate molecular evidence, ONB is considered to develop from olfactory sensory neurons (OSNs). Here, we immunohistochemically detected intense signals for the olfactory-specific sensory transduction proteins, G(αolf), adenylyl cyclase III, and cyclic-nucleotide-gated channel A2 in ONB, together with the conventional ONB marker, neuron-specific enolase, while the established OSN markers, olfactory marker protein and growth-associated protein 43, were not detected. These results indicate that ONB and OSNs share the same lineage and that the detected transduction proteins could serve as specific tumor markers for ONB.
authors.affiliation: The BCPH Unit of Molecular Physiology, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Matayoshi
authors.forename: Joji M
authors.initials: JM
authors.lastname: Otaki
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000328:Adult; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000378:metabolism*; D018304:Esthesioneuroblastoma, Olfactory; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009669:Nose Neoplasms; D015398:Signal Transduction
chemical_list: D054815:Cyclic Nucleotide-Gated Cation Channels; D009419:Nerve Tissue Proteins; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D000262:Adenylyl Cyclases; C421784:adenylate cyclase 3