title: Efficacy of sublingual administration of detomidine gel for sedation of horses undergoing veterinary and husbandry procedures under field conditions.
abstract: OBJECTIVE
  To determine whether sublingual detomidine gel administration to horses would be effective in providing an appropriate degree of sedation and restraint to facilitate completion of veterinary and husbandry procedures under field conditions.
  
  
  METHODS
  Multicenter, prospective, randomized, blinded, placebo-controlled clinical study.
  
  
  METHODS
  270 client-owned horses known to require sedation or strong restraint to enable veterinary and husbandry procedures to be performed.
  
  
  METHODS
  Horses randomly received a single dose of detomidine gel (0.04 mg/kg [0.018 mg/lb]) or placebo gel administered sublingually. Horses were sedated to facilitate cleaning the prepuce, cutting of hair with electric clippers, hoof trimming or application of shoes, manual dental floating (ie, rasping or filing of the teeth to remove irregularities), nasogastric passage of a stomach tube or endoscope, and radiography. The primary determinant of efficacy was an assessment by a veterinarian on the ability or inability to successfully conduct the procedure.
  
  
  RESULTS
  171 horses met all the study protocol criteria. One hundred twenty-nine horses were treated with detomidine. The procedure was completed successfully for 76% (98/129) of the detomidine-treated horses, while the procedure was completed successfully for only 7% (3/42) of the placebo-treated horses. The percentage of horses in which the procedure was successfully completed was significantly different between detomidine-treated horses and placebo-treated horses. No serious adverse effects were reported.
  
  
  CONCLUSIONS
  Detomidine gel administered to horses sublingually at a dose of 0.04 mg/kg provided an appropriate degree of sedation and restraint to facilitate completion of veterinary and husbandry procedures in horses known to require sedation for such procedures.
authors.affiliation: BW Furlong and Associates, 101 Homestead Rd, Oldwick, NJ 08858, USA.
authors.forename: Rachel B
authors.initials: RB
authors.lastname: Gardner
authors.forename: Gary W
authors.initials: GW
authors.lastname: White
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Ramsey
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Boucher
authors.forename: W Randal
authors.initials: WR
authors.lastname: Kilgore
authors.forename: Mirja K
authors.initials: MK
authors.lastname: Huhtinen
mesh_terms: D000286:Administration, Sublingual; D000818:Animals; D016292:Procedural Sedation / Q000662:veterinary; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male
chemical_list: D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine