title: [Overcoming of radiation resistances].
abstract: Despite good achievements in prevention and control, cancer is still a leading cause of death worldwide. The development of resistances against conventional treatment modalities is one of the main causes of failure in the treatment of cancer. Radio- and chemotherapies fail frequently due to intrinsic or acquired resistances in apoptotic signalling pathways or alterations in DNA-repair processes. Targeted radiotherapies employing α-particle-emitting radionuclides and Auger-emitting electrons are a promising approach in cancer treatment to break radio- and chemoresistance by overcoming DNA-repair mechanisms and reversing deficient activation of apoptotic pathways in cancer cells.
authors.affiliation: Institut für Rechtsmedizin, Universität Ulm, Prittwitzstr. 6, 89075 Ulm. claudia.friesen@uni-ulm.de
authors.forename: C
authors.initials: C
authors.lastname: Friesen
authors.forename: I
authors.initials: I
authors.lastname: Hormann
authors.forename: M
authors.initials: M
authors.lastname: Roscher
authors.forename: S
authors.initials: S
authors.lastname: Bacher
authors.forename: E
authors.initials: E
authors.lastname: Miltner
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D011836:Radiation Tolerance; D020266:Radiotherapy, Conformal / Q000639:trends*; D017211:Treatment Failure