title: Primary cutaneous anaplastic large-cell lymphoma.
abstract: Primary cutaneous anaplastic large-cell lymphoma (ALCL) is a form of cutaneous T-cell lymphoma that is characterized by solitary or localized nodules or plaques. Histopathologic features include a diffuse, non-epidermotropic infiltrate with cohesive sheets of large anaplastic CD30+ tumor cells. This entity must be distinguished from systemic ALCL with cutaneous involvement and lymphomatoid papulosis. Treatment modalities include clinical monitoring, radiation therapy, and surgical excision, with systemic chemotherapy reserved for disseminated or extracutaneous disease.
authors.affiliation: Department of Dermatology, New York University, New York, NY, USA.
authors.forename: Tracey
authors.initials: T
authors.lastname: Newlove
authors.forename: Aaron
authors.initials: A
authors.lastname: Loyd
authors.forename: Rishi
authors.initials: R
authors.lastname: Patel
authors.forename: Josef
authors.initials: J
authors.lastname: Jelinek
authors.forename: Jo-Ann
authors.initials: JA
authors.lastname: Latkowski
mesh_terms: D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D017730:Ki-1 Antigen