title: Cysteine-activated hydrogen sulfide (H2S) donors.
abstract: H(2)S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H(2)S has been hindered by the lack of controllable H(2)S donors that could mimic the slow and continuous H(2)S generation process in vivo. Herein we report a series of cysteine-activated H(2)S donors. Structural modifications of these molecules can regulate the rates of H(2)S generation. These compounds can be useful tools in H(2)S research.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D003545:Cysteine / Q000378:metabolism*; D006862:Hydrogen Sulfide / Q000378:metabolism*; D007700:Kinetics
chemical_list: D003545:Cysteine; D006862:Hydrogen Sulfide