title: Fatal Subacute Hepatic Failure in a Patient with AA-Type Amyloidosis: Case Report.
abstract: Although systemic amyloidosis of amyloid-associated protein (AA) type (secondary or reactive amyloidosis) frequently involves the liver, it rarely causes clinically apparent liver disease. Mild elevation of alkaline phosphatase and hepatomegaly are the most common biochemical and clinical findings, respectively. We report a case of systemic amyloidosis of AA type, which clinically presented as subacute hepatic failure and resulted in a fatal clinical course in a 69-year-old man. To the best of our knowledge, this is the fifth case of hepatic amyloidosis of AA type that clinically presented as fatal subacute hepatic failure, an unusual clinical presentation for hepatic involvement by systemic AA-type amyloid.
authors.affiliation: Department of Hepatobiliary and Liver Transplantation, King Abdulaziz Medical City, P.O. Box 22490, Riyadh 11426, Saudi Arabia.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Altraif
authors.forename: Fayaz A
authors.initials: FA
authors.lastname: Handoo
authors.forename: Khaled O
authors.initials: KO
authors.lastname: Alsaad
authors.forename: Adel
authors.initials: A
authors.lastname: Gublan