title: The bioavailability of eicosapentaenoic acid from reconstituted triglyceride fish oil is higher than that obtained from the triglyceride and monoglyceride forms.
abstract: Omega 3 fatty acids have healthcare benefits, but their absorption characteristics are not well defined, particularly for strategies to improve their bioavailability. We performed a double blind study comparing the bioavailability of 20% eicosapentaenoic acid in 4.5 grams of: natural triglyceride, reconstituted triglyceride, enzymatically synthesized triglyceride, monoglyceride and diglyceride. Seven healthy volunteers were given the supplements on five occasions while repeated measurements of eicosapentaenoic acid were taken to calculate the area under the curve for the next 24 hours. There was a significant difference between the mean of calculated area under the curve of eicosapentaenoic acid from reconstituted triglyceride (30.2) and that of the enzymatically synthesized triglyceride (11.9) and monoglyceride (13.4), z=-2.36 and -2.19, respectively, p<0.05. In summary, eicosapentaenoic acid bioavailability of chemically reconstituted triglycerides was better than that obtained from enzymatically synthesized triglyceride and monoglyceride.
authors.affiliation: Hull Royal Infirmary, Michael White Diabetes Centre, Hull, UK. ammar.wakil@gmail.com
authors.forename: Ammar
authors.initials: A
authors.lastname: Wakil
authors.forename: Miquel
authors.initials: M
authors.lastname: Mir
authors.forename: Duane D
authors.initials: DD
authors.lastname: Mellor
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Mellor
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Atkin
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005395:Fish Oils / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D050178:Monoglycerides / Q000097:blood / Q000493:pharmacokinetics*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D005395:Fish Oils; D050178:Monoglycerides; D014280:Triglycerides; D015118:Eicosapentaenoic Acid