title: Enantioselective synthesis of optically pure β-amino ketones and γ-aryl amines by Rh-catalyzed asymmetric hydrogenation.
abstract: A series of optically pure β-amino ketones have been synthesized in high enantioselectivities (ee > 99%) by Rh-DuanPhos-catalyzed asymmetric hydrogenation of readily prepared β-keto enamides. Further reduction of these β-amino ketones with hydrogen and Pd/C leads to the formation of a variety of protected enantiomerically pure γ-aryl amines (ee > 99%), which are key building blocks in many bioactive molecules.
authors.affiliation: College of Science, Northwest Agriculture & Forestry University, Yangling, Shaanxi 712100, P. R. China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Geng
authors.forename: Kexuan
authors.initials: K
authors.lastname: Huang
authors.forename: Tian
authors.initials: T
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhang
authors.forename: Le
authors.initials: L
authors.lastname: Zhou
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wu
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007659:Ketones; D012238:Rhodium