title: Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest.
abstract: Investigation of the endemic Madagascar plant Leptadenia madagascariensis Decne. (Apocynaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the four new cardenolides 1-4. The structure elucidations of these compounds were based on analyzes of their 1D and 2D NMR spectra and mass spectrometric data. The cardenolides were strongly antiproliferative to the A2780 ovarian cancer cell line, with IC(50) values of 0.18, 0.21, 0.17, and 0.29μM line, and to the H460 human lung cancer cell line, with IC(50) values of 0.16, 0.68, 0.37, and 0.48μM, respectively.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States.
authors.forename: Ende
authors.initials: E
authors.lastname: Pan
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.forename: Martin
authors.initials: M
authors.lastname: Callmander
authors.forename: Stephan
authors.initials: S
authors.lastname: Rakotonandrasana
authors.forename: Etienne
authors.initials: E
authors.lastname: Rakotobe
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: Karen
authors.initials: K
authors.lastname: Tendyke
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.forename: Edward M
authors.initials: EM
authors.lastname: Suh
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D008270:Madagascar; D010051:Ovarian Neoplasms / Q000473:pathology
chemical_list: D002298:Cardenolides