title: Laparoscopy-assisted total gastrectomy for advanced gastric cancer with carcinomatous ascites after S1 plus cisplatin chemotherapy: a case report.
abstract: A 29-year-old man with a type 4 tumor, in the lower third of the stomach, and carcinomatous ascites was diagnosed by aspiration cytology of the ascitic fluid. Curative resection was considered impossible, and S1 (120 mg/d) and cisplatin (90 mg/d) were given for 21 days in 1 course. The cancer lesion showed marked remission (partial response), and the ascites completely disappeared after the fourth course. Twenty-five days after completion of the S1 treatment, laparoscopy-assisted total gastrectomy was performed. Histopathological examination showed no remnant cancer cells in the resected specimen and no lymph node metastases. The tumor was replaced with fibrosis having a granulomatous change. The patient's postoperative course was uneventful. The patient was continued with S1 monotherapy after surgery, and no signs of recurrence or metastases have been seen on any examination 12 months after the surgery.
authors.affiliation: Department of Surgery, International University of Health and Welfare Hospital, Nasushiobara, Tochigi, Japan. ohdaira@iuhw.ac.jp
authors.forename: Hironori
authors.initials: H
authors.lastname: Ohdaira
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Mai
authors.initials: M
authors.lastname: Tsutsui
authors.forename: Taizo
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Munefumi
authors.initials: M
authors.lastname: Arita
authors.forename: Takuji
authors.initials: T
authors.lastname: Noro
authors.forename: Naruo
authors.initials: N
authors.lastname: Kawasaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ohara
authors.forename: Keiichi
authors.initials: K
authors.lastname: Yoshino
authors.forename: Hajime
authors.initials: H
authors.lastname: Kuroda
authors.forename: Masaki
authors.initials: M
authors.lastname: Kitajima
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001201:Ascites / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004338:Drug Combinations; D016099:Endoscopy, Gastrointestinal; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin