title: Vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk: a meta-analysis involving 4,138 subjects.
abstract: The association between vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk is still controversial and ambiguous. The objective of our study was to investigate this association. The Medline and Embase databases were searched by two investigators. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to test the association between VEGF +936 C/T polymorphisms and gastric cancer risk. Our meta-analysis comprised seven case-control studies, which included 1,893 gastric cancer cases and 2,245 controls. The combined results showed that there was no relationship between VEGF +936 C/T gene polymorphisms and gastric cancer risk (CC: OR 0.97, 95% CI 0.85, 1.11; CT: OR 1.01, 95% CI 0.88, 1.16; TT: OR 1.10, 95% CI 0.79, 1.55). Subgroup analysis by ethnicity and stage, location, and Lauren classification of gastric cancer did not change the results. This meta-analysis suggests that there is no association between VEGF +936 C/T polymorphisms and gastric cancer risk. Further studies should pay attention to other potentially functional SNPs.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Wen
authors.initials: W
authors.lastname: Hu
authors.forename: Wen
authors.initials: W
authors.lastname: Zhuang
authors.forename: Guan-Jian
authors.initials: GJ
authors.lastname: Liu
authors.forename: Tai-Xiang
authors.initials: TX
authors.lastname: Wu
authors.forename: Xun
authors.initials: X
authors.lastname: Yao
authors.forename: Liang
authors.initials: L
authors.lastname: Du
authors.forename: Mao-Ling
authors.initials: ML
authors.lastname: Wei
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Wu
mesh_terms: D044466:Asian People; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D044465:White People
chemical_list: D042461:Vascular Endothelial Growth Factor A