title: Role of Ca(V)2.1-mediated NMDA receptor signaling in the nucleus accumbens in spatial short-term memory.
abstract: Heterozygous rolling Nagoya (rol/+) mice with a Ca(V)2.1α₁ mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0 μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5 μg/side) or Ca(V)2.1 inhibitor levetiracetam (0.1 μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that Ca(V)2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.
authors.affiliation: Research Resources Center, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, Saitama, 351-0198, Japan. etakahashi@brain.riken.jp
authors.forename: Eiki
authors.initials: E
authors.lastname: Takahashi
authors.forename: Kimie
authors.initials: K
authors.lastname: Niimi
authors.forename: Chitoshi
authors.initials: C
authors.lastname: Itakura
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D020864:Calcium Channels, N-Type / Q000235:genetics / Q000378:metabolism*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D000077287:Levetiracetam; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D016202:N-Methylaspartate / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D010889:Piracetam / Q000031:analogs & derivatives / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*
chemical_list: D020864:Calcium Channels, N-Type; D016291:Dizocilpine Maleate; D018691:Excitatory Amino Acid Antagonists; D000077287:Levetiracetam; D016202:N-Methylaspartate; D010889:Piracetam; D016194:Receptors, N-Methyl-D-Aspartate