title: Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection: a cohort study with 945 patients.
abstract: BACKGROUND
  Diabetes mellitus plays an important role in cancer prevalence and outcomes. The aim of this study was to evaluate the influence of DM on stages and outcomes among patients with colorectal cancer.
  
  
  METHODS
  The study enrolled 945 patients who were diagnosed as having colorectal carcinoma from August 1994 to December 2002. In the cohort, 26 patients were diagnosed as having DM. With a median follow-up of 45.8 months, differences in overall survival and disease-free survival between the diabetes and non-diabetes groups were analyzed.
  
  
  RESULTS
  Kaplan and Meier analysis showed that there were no significant differences between the two groups in overall survival rates at 3 years or 5 years. At 5 years, patients with DM, compared with patients without diabetes, experienced a significantly lower disease-free survival rate (34.2% diabetics vs. 55.1% non-diabetics; P = 0.025).
  
  
  CONCLUSIONS
  DM was associated with an increased risk of recurrence in patients with colorectal cancer.
authors.affiliation: Department of Gastrointestinal and Colorectal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
authors.forename: Chuang-Qi
authors.initials: CQ
authors.lastname: Chen
authors.forename: Le-Kun
authors.initials: LK
authors.lastname: Fang
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Cai
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Ma
authors.forename: Guang-Xin
authors.initials: GX
authors.lastname: Yang
authors.forename: Wan
authors.initials: W
authors.lastname: Yang
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhan
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000401:mortality*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged