title: [The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats].
abstract: OBJECTIVE
  To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.
  
  
  METHODS
  SD rats were divided into three groups: Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.
  
  
  RESULTS
  There was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.
  
  
  CONCLUSIONS
  Ang-(1-7) can relieve the renal process of diabetic rats.
authors.affiliation: Department of Endocrinology, The Affiliated No. 1 Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Shuo-ping
authors.initials: SP
authors.lastname: Chen
authors.forename: Jing-chen
authors.initials: JC
authors.lastname: Zheng
authors.forename: Lian-Song
authors.initials: LS
authors.lastname: Ni
authors.forename: Guo-rong
authors.initials: GR
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; D053773:Transforming Growth Factor beta1; D000803:Angiotensin I; C118790:angiotensin I (1-7)