title: p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells.
abstract: The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p53 in the curtailment of tumor progression and colonization of secondary sites by negatively regulating tumor cell metastasis ( 4;5) . Recently, we have found that p53 suppresses Src-induced formation of podosomes and associated invasive phenotypes in fibroblasts and vascular smooth muscle cells (VSMC) ( 6;7) . In this review, I will focus on some recent studies that have identified p53 as a suppressor of cell migration and invasion in general, and VSMC podosome formation and ECM degradation in particular.
authors.affiliation: Department of Biochemistry, Queen's University, Kingston, Ontario, Canada. maka@queensu.ca
authors.forename: Alan S
authors.initials: AS
authors.lastname: Mak
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002148:Calmodulin-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D002450:Cell Communication; D002465:Cell Movement; D051356:Cortactin / Q000235:genetics / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D016158:Genes, p53; D016391:Genes, src; D006801:Humans; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D012397:Rosette Formation; D050796:STAT3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D000199:Actins; D002148:Calmodulin-Binding Proteins; D051356:Cortactin; D050796:STAT3 Transcription Factor; D016159:Tumor Suppressor Protein p53; D051059:PTEN Phosphohydrolase