title: Unexplored nucleophilic ring opening of aziridines.
abstract: The reactivity of dianions of carboxylic acids towards aziridines has been studied. Although, a similar reactivity to that of enolates from ketones, esters or amides has been observed, the method directly yields γ-aminoacids in one step. The method is complementary of previous results of enenediolate reactivity with other electrophiles. A comparative study with the reactivity of this enediolates with epoxides is included.
authors.affiliation: Instituto de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, 46100 Burjassot, Spain. Ana.costero@uv.es
authors.forename: Ana María
authors.initials: AM
authors.lastname: Costero
authors.forename: Salvador
authors.initials: S
authors.lastname: Gil
authors.forename: Margarita
authors.initials: M
authors.lastname: Parra
authors.forename: Pablo
authors.initials: P
authors.lastname: Rodríguez
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D001388:Aziridines / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D007659:Ketones / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001388:Aziridines; D004852:Epoxy Compounds; D007659:Ketones