title: Insulin signaling: inositol phosphates get into the Akt.
abstract: An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophosphate IP7, which is produced in response to insulin, inhibits the Akt kinase, a primary effector of insulin signaling.
authors.affiliation: Department of Genetics and Complex Diseases, Harvard School of Public Heath, Boston, MA 02115, USA. bmanning@hsph.harvard.edu
authors.forename: Brendan D
authors.initials: BD
authors.lastname: Manning