title: Primary pleural epithelioid hemangioendothelioma (EHE)--two cases and review of the literature.
abstract: BACKGROUND
  We present two cases with symptoms of progressively worsening cough, dyspnea, decreased exercise tolerance and right-sided back pain in the first case and upper respiratory symptoms characterized by cough and a low grade fever in the second case.
  
  
  METHODS
  Report of two cases.
  
  
  RESULTS
  The initial chest X-ray in both the cases showed pleural effusion. Further imaging with computed tomography of the chest confirmed the effusion in both cases. Thoracentesis was done in both of them revealed an exudative effusion that did not reveal any infection or malignancy. Both cases underwent surgical biopsy and the diagnosis of primary pleural epithelioid hemangioendothelioma was made.
  
  
  CONCLUSIONS
  Both the cases had progressive clinical deterioration despite chemotherapy with Taxol and Bevacizumab in one case and carboplatin, etoposide, and bevacizumab, in the second case. Both developed metastatic disease to lungs and died.
authors.affiliation: Uniformed Services University, National Naval Medical Center, Bethesda, MD, USA. angeline.lazarus@med.navy.mil
authors.forename: Angeline
authors.initials: A
authors.lastname: Lazarus
authors.forename: Gregory
authors.initials: G
authors.lastname: Fuhrer
authors.forename: Christina
authors.initials: C
authors.lastname: Malekiani
authors.forename: Sean
authors.initials: S
authors.lastname: McKay
authors.forename: John
authors.initials: J
authors.lastname: Thurber
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D018323:Hemangioendothelioma, Epithelioid / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D019152:Paracentesis; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D014057:Tomography, X-Ray Computed