title: Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: an update.
abstract: OBJECTIVE
  What is the current evidence regarding the association between hemorrhagic disease of the newborn and maternal use of hepatic enzyme-inducing antiepileptic drugs (eg, carbamazepine, phenobarbitone, topiramate)?
  
  
  CONCLUSIONS
  Women with epilepsy who take enzyme-inducing antiepileptic drugs should be advised that there is no adequate evidence to support or refute taking vitamin K in late pregnancy to prevent bleeding complications in a newborn.
authors.affiliation: Motherisk Team, Hospital for Sick Children, Toronto.
authors.forename: Aleksey
authors.initials: A
authors.lastname: Kazmin
authors.forename: Renee C
authors.initials: RC
authors.lastname: Wong
authors.forename: Mathew
authors.initials: M
authors.lastname: Sermer
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011295:Prenatal Care; D012955:Societies, Medical; D014812:Vitamin K / Q000008:administration & dosage / Q000627:therapeutic use*; D006475:Vitamin K Deficiency Bleeding / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000927:Anticonvulsants; D014812:Vitamin K