title: [The impact of detecting endothelial dysfunction in atherosclerosis: Role of positron emission tomography (PET)].
abstract: The endothelium plays an important role in the regulation of the intracellular fluid, vascular permeability, and modulation of vascular focal tone and angiogenesis. Endothelial dysfunction is manifested by the loss of the endothelium ability to modulate physiology changes in its vascular bed, and actually it is considered a prognostic marker of coronary artery disease. The relevance of assessing endothelial dysfunction relies in that it has been observed in different pathologies like DM, dyslipidemia, hypertension, tabaquism and in immunologic diseases like antiphospholipid syndrome and systemic lupus. PET is a non invasive method that allows the absolute quantification of myocardial blood flow during rest, stress and adrenergic stimulation, which allows to asses endothelial function. Therefore PET is a useful diagnostic technique to identify patients with endothelial dysfunction, and in the assessment of its response to administered therapy, allowing an optimal control and prevention of secondary adverse events of these diseases.
authors.affiliation: "Departamento de Medicina Nuclear, Instituto Nacional de Cardiología Ignacio Chávez. México, D.F. Unidad PET/CT Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México. México, D.F.
authors.forename: Erick
authors.initials: E
authors.lastname: Alexánderson-Rosas
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Calleja-Torres
authors.forename: Alfonso
authors.initials: A
authors.lastname: Martínez-García
authors.forename: Pedro Alberto
authors.initials: PA
authors.lastname: Lamothe-Molina
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Ochoa-López
authors.forename: Gabriela
authors.initials: G
authors.lastname: Meléndez
authors.forename: Eric
authors.initials: E
authors.lastname: Kimura-Hayama
authors.forename: Aloha
authors.initials: A
authors.lastname: Meave-González
mesh_terms: D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D049268:Positron-Emission Tomography