title: Effect of inhibitors of inducible and neuronal NO synthases on the development of audiogenic stress-induced damage in Krushinskii-Molodkina rats.
abstract: Experiments on the models of epileptiform seizure and hemorrhagic stroke (Krushinskii-Molodkina rats) showed that selective inhibitors of inducible and neuronal NO synthases (aminoguanidine and 7-nitroindazole) significantly decrease the mortality rate, reduce the severity of motor disorders, and prevent the development of intracranial hemorrhages under conditions of audiogenic stress.
authors.affiliation: Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Krushinskii
authors.forename: V S
authors.initials: VS
authors.lastname: Kuzenkov
authors.forename: V E
authors.initials: VE
authors.lastname: D'yakonova
authors.forename: V P
authors.initials: VP
authors.lastname: Reutov
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D007191:Indazoles / Q000627:therapeutic use*; D008297:Male; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors*; D052250:Nitric Oxide Synthase Type III / Q000037:antagonists & inhibitors*; D051381:Rats; D012640:Seizures / Q000188:drug therapy / Q000517:prevention & control; D012771:Shock, Hemorrhagic / Q000517:prevention & control; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D004791:Enzyme Inhibitors; D006146:Guanidines; D007191:Indazoles; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III; C004479:pimagedine; C080122:7-nitroindazole