title: Folic acid conjugates for nuclear imaging of folate receptor-positive cancer.
abstract: The folate receptor (FR) is overexpressed on a variety of tumor types, whereas its distribution in normal tissues and organs is highly limited. Exploration of the utility of the FR revealed its promising potential for targeting with folate-based radiopharmaceuticals. Herein, we report the principle of the FR-targeting strategy and summarize the development of several folic acid radioconjugates useful for SPECT and PET of cancer diseases. The potential applicability of folate radiopharmaceuticals for FR-targeted radionuclide therapy is also discussed.
authors.affiliation: Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland. cristina.mueller@psi.ch
authors.forename: Cristina
authors.initials: C
authors.lastname: Müller
authors.forename: Roger
authors.initials: R
authors.lastname: Schibli
mesh_terms: D058973:Folate Receptors, GPI-Anchored / Q000032:analysis*; D005492:Folic Acid / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D058973:Folate Receptors, GPI-Anchored; D019275:Radiopharmaceuticals; D005492:Folic Acid