title: [44-year-old woman with elevated liver enzymes and a family history for cholelithiasis].
abstract: "Low phospholipid associated cholelithiasis" (LPAC) syndrome is an important differential diagnosis in younger patients with biliary symptoms after cholecystectomy and concomitant elevated serum liver tests. Typical symptoms include recurrence of biliary colics after cholecystectomy, echogenic material in the intrahepatic bile ducts, intrahepatic cholestasis of pregnancy or cholestasis under hormonal contraception and a family history of gallstone disease. Patients with LPAC syndrome can be successfully treated with ursodeoxycholic acid.
authors.affiliation: Medizinische Klinik und Poliklinik II, LMU Klinikum der Universität München - Campus Großhadern, Marchioninistraße 15, 81377, München, Deutschland. corinna.hopf@med.uni-muenchen.de
authors.forename: C
authors.initials: C
authors.lastname: Hopf
authors.forename: U
authors.initials: U
authors.lastname: Beuers
authors.forename: H
authors.initials: H
authors.lastname: Bikker
authors.forename: G U
authors.initials: GU
authors.lastname: Denk
authors.forename: C
authors.initials: C
authors.lastname: Rust
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D000483:Alleles; D001219:Aspartate Aminotransferases / Q000097:blood*; D001649:Bile Duct Diseases / Q000175:diagnosis*; D001653:Bile Ducts, Intrahepatic; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000175:diagnosis* / Q000235:genetics* / Q000601:surgery; D003085:Colic / Q000209:etiology; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D008111:Liver Function Tests; D010375:Pedigree; D010743:Phospholipids / Q000172:deficiency*; D017354:Point Mutation / Q000235:genetics; D017562:Postcholecystectomy Syndrome / Q000175:diagnosis* / Q000209:etiology; D013577:Syndrome; D014463:Ultrasonography; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D010743:Phospholipids; C095122:multidrug resistance protein 3; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase