title: Hypermethylation-mediated reduction of LMX1A expression in gastric cancer.
abstract: LMX1A is epigenetically inactivated in cervical cancer. However, the expression and methylation status of LMX1A in gastric cancer tissues remains unknown. In the present study, we found that the expression of LMX1A was significantly decreased in gastric cancer tissues compared with normal tissues. A statistically significant inverse association was found between the LMX1A methylation status and expression of LMX1A in tumor tissues (P = 0.008). Restoration of LMX1A induced cell apoptosis and suppressed anchorage-independent growth, suggesting LMX1A may be a potential biomarker for gastric cancer.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Dong
authors.forename: Li
authors.initials: L
authors.lastname: Feng
authors.forename: Yun
authors.initials: Y
authors.lastname: Xie
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Yunlin
authors.initials: Y
authors.lastname: Wu
mesh_terms: D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D015153:Blotting, Western; D002469:Cell Separation; D019175:DNA Methylation / Q000235:genetics*; D005434:Flow Cytometry; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D060850:LIM-Homeodomain Proteins; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors
chemical_list: D014408:Biomarkers, Tumor; D018398:Homeodomain Proteins; D060850:LIM-Homeodomain Proteins; C078021:LMX1A protein, human; D014157:Transcription Factors