title: Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1β in the rat eye retinal neurons.
abstract: Proinflammatory cytokine IL-1β specifically stimulates caspase-3/7 in vitro in RGC-5 rat eye retinal neurons. Insulin and insulin-like growth factor-1 and their combination inhibit caspase-3/7 activation in these cells, induced by removal of the serum from culture medium and/or by IL-1β treatment.
authors.affiliation: Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow. sainhershy@yandex.ru
authors.forename: S S
authors.initials: SS
authors.lastname: Shushanov
mesh_terms: D000818:Animals; D053148:Caspase 3 / Q000378:metabolism*; D053179:Caspase 7 / Q000378:metabolism*; D002460:Cell Line; D007328:Insulin / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000494:pharmacology*; D015850:Interleukin-6 / Q000494:pharmacology; D051381:Rats; D055351:Retinal Neurons / Q000187:drug effects* / Q000201:enzymology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D007328:Insulin; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007334:Insulin-Like Growth Factor I; D053148:Caspase 3; D053179:Caspase 7