title: In vitro activity and in vivo efficacy of anidulafungin in murine infections by Aspergillus flavus.
abstract: Anidulafungin (AFG) showed high activity against 27 strains of Aspergillus flavus by use of broth microdilution and disk diffusion methods. This drug was effective in vivo in a murine model of disseminated infection with five isolates tested. AFG was able to prolong survival and reduce tissue burden of infected mice but not able to reduce galactomannan serum concentrations. The AFG serum levels were above the corresponding minimum effective concentrations (MEC) for all of the strains tested.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Calvo
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.forename: Valentina
authors.initials: V
authors.lastname: Salas
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000097:blood* / Q000627:therapeutic use*; D001228:Aspergillosis / Q000097:blood / Q000188:drug therapy; D001231:Aspergillus flavus / Q000187:drug effects* / Q000472:pathogenicity*; D054714:Echinocandins / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D051379:Mice
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin