title: [Safety of rheumatic disease drugs at childbearing age].
abstract: The aim of this study is to determine the safety of commonly prescribed antirheumatic drugs at childbearing age, in pregnancy and lactation, through systematic literature review. Patients who take cytotoxic drugs should be informed of the risks of impared fertility. During pregnancy, non steroidal anti-inflammatory drugs (NSAIDs) can be safely administered until gestational week 32. Acetaminophen and low to moderate doses of corticosteroids are safe. Among, the disease-modifying agents, antimalarial agents, sulfasalazine, azathioprine and ciclosporin are compatible with pregnancy, and can be administered until birth. Paracetamol, prednison, antimalarial agents, sulfasalazine and most NSAIDs can safely be used by lactating mothers. To ensure a favourable outcome for both the mother and the child, the pregnancy should be planned, started during a period of disease stability, monitored closely and treated as needed.
authors.affiliation: Service de Rhumatologie, CHU Fattouma Bourguiba de Monastir, Monastir, Tunisie. saoussenzrour@yahoo.fr
authors.forename: Saoussen
authors.initials: S
authors.lastname: Zrour-Hassen
authors.forename: Mahbouba
authors.initials: M
authors.lastname: Jguirim
authors.forename: Karim
authors.initials: K
authors.lastname: Aouam
authors.forename: Wided
authors.initials: W
authors.lastname: Korbaa
authors.forename: Mohamed
authors.initials: M
authors.lastname: Younes
authors.forename: Ismail
authors.initials: I
authors.lastname: Bejia
authors.forename: Mongi
authors.initials: M
authors.lastname: Touzi
authors.forename: Naceur
authors.initials: N
authors.lastname: Bergaoui
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007774:Lactation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D012216:Rheumatic Diseases / Q000150:complications / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D005938:Glucocorticoids