title: Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels.
  
  
  METHODS
  Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure.
  
  
  METHODS
  Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation.
  
  
  METHODS
  Restoration of ovarian activity.
  
  
  RESULTS
  Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg.
  
  
  CONCLUSIONS
  Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.
authors.affiliation: Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Unité de Recherche GYNE, Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels, Belgium. jacques.donnez@uclouvain.be
authors.forename: Jacques
authors.initials: J
authors.lastname: Donnez
authors.forename: Jean
authors.initials: J
authors.lastname: Squifflet
authors.forename: Pascale
authors.initials: P
authors.lastname: Jadoul
authors.forename: Dominique
authors.initials: D
authors.lastname: Demylle
authors.forename: Anne-Céline
authors.initials: AC
authors.lastname: Cheron
authors.forename: Anne
authors.initials: A
authors.lastname: Van Langendonckt
authors.forename: Marie-Madeleine
authors.initials: MM
authors.lastname: Dolmans
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005615:Freezing; D018380:Hematopoietic Stem Cell Transplantation; D006358:Hot Temperature; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology / Q000534:rehabilitation* / Q000628:therapy*; D010053:Ovary / Q000502:physiology / Q000637:transplantation*; D011247:Pregnancy; D014182:Transplantation, Autologous