title: Characterization of physiologic 18F-FDG uptake with PET-CT in dogs.
abstract: We evaluated the whole body distribution of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) in seven beagle dogs using positron emission tomography/computed tomography. The mean and maximum standard uptake values (SUV) for various tissues were computed. The SUV of the aortic blood pool was 0.65 +/- 0.19. Moderate uptake was present in brain (3.40 +/- 1.01). Mild uptake was present in orbital muscles, soft palate, laryngeal and pharyngeal region, mandibular salivary gland, myocardium, liver, pancreas, kidney, and intestine. 18F-FDG uptake would be normally higher in these tissues because of normal physiologic activity. Mean and maximum SUV values of the eye, skeletal muscle, bone tissue, spleen, adrenal gland, stomach, tongue, gall bladder, and lung were similar to or lower than that of the aortic blood pool. These data provide a normal baseline for comparing pathologic 18F-FDG uptake.
authors.affiliation: Department of Veterinary Radiology & Diagnostic Imaging, College of Veterinary Medicine, Konkuk University, 1, Hwayang-dong, Kwangjin-ku, Seoul 143-701, Korea.
authors.forename: Min-Su
authors.initials: MS
authors.lastname: Lee
authors.forename: Ah-Ra
authors.initials: AR
authors.lastname: Lee
authors.forename: Mi-Ae
authors.initials: MA
authors.lastname: Jung
authors.forename: In-Hye
authors.initials: IH
authors.lastname: Lee
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Choi
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Chung
authors.forename: Soon-Wuk
authors.initials: SW
authors.lastname: Jeong
authors.forename: Sang-Soep
authors.initials: SS
authors.lastname: Nahm
authors.forename: Ki-Dong
authors.initials: KD
authors.lastname: Eom
mesh_terms: D000818:Animals; D004285:Dogs / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods / Q000662:veterinary*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012016:Reference Values; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000662:veterinary*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18