title: HIV vaccine development: past, present and future.
abstract: The search for an HIV vaccine began following the discovery of the virus more than 25 years ago. Despite important progress, an effective vaccine remains an elusive goal that will likely require many more years of R&D to achieve. Following recent advances in research, however, there has been increased optimism that a prophylactic HIV vaccine is feasible. A consensus is forming among researchers to support a larger role for proof-of-concept efficacy clinical trials, conducted in parallel with invigorated basic research efforts and testing in animal models, to accelerate the discovery of key principles that will guide rational vaccine development.
authors.affiliation: US Military HIV Research Program, 1600 Gude Drive, Rockville, MD 20850, USA. mrobb@hivresearch.org
authors.forename: Merlin L
authors.initials: ML
authors.lastname: Robb
mesh_terms: D016915:AIDS Vaccines / Q000266:history* / Q000276:immunology* / Q000627:therapeutic use; D000818:Animals; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D012107:Research Design
chemical_list: D016915:AIDS Vaccines