title: Fluorescence sensors for lithium ions and small peptides.
abstract: Simple but powerful chemosensors were developed by taking advantage of self-assembly processes. First, we will describe a turn-on fluorescent sensor for the pharmacologically important lithium ion. The sensor can be used in purely aqueous solution, and it displays a very high selectivity for lithium over sodium and magnesium ions. It is based on a metallacrown receptor unit, which can be assembled in situ from simple building blocks. Furthermore, we will describe a cross-reactive sensor array for the detection of small peptides. The individual sensors of the array are formed by mixing metal complexes with fluorescent dyes.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, Institut des Sciences et Ingénierie Chimiques, CH-1015 Lausanne. sebastein.rochat@epfl.ch
authors.forename: Sébastien
authors.initials: S
authors.lastname: Rochat
authors.forename: Kay
authors.initials: K
authors.lastname: Severin
mesh_terms: D002414:Cations, Monovalent / Q000032:analysis / Q000097:blood; D047248:Crown Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D018020:Lithium Compounds / Q000032:analysis* / Q000097:blood; D009942:Organometallic Compounds / Q000737:chemistry*; D010455:Peptides / Q000032:analysis* / Q000097:blood; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D002414:Cations, Monovalent; D047248:Crown Compounds; D005456:Fluorescent Dyes; D018020:Lithium Compounds; D009942:Organometallic Compounds; D010455:Peptides