title: Bilateral pallidal deep brain stimulation in primary Meige syndrome.
abstract: Primary Meige syndrome is an idiopathic movement disorder that manifests as craniofacial and often cervical dystonias. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has emerged as a powerful surgical option in the treatment of primary generalized or segmental dystonia. However, the experience with GPi-DBS in Meige syndrome is limited. We followed 5 patients with disabling Meige syndrome treated by bilateral GPi-DBS for 49 ± 43.7 (mean ± SD) months. All patients were assessed before surgery and at the last follow-up after surgery using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) which includes both the movement and disability scales. Bilateral GPi-DBS produced a sustained and long-lasting improvement in dystonia symptoms associated with Meige syndrome. At the last follow-up, the mean scores of BFMDRS movement and disability scales improved significantly by 84 ± 6.8% (range, 75-94%) and 89 ± 8.1% (range, 80-100%), respectively. Bilateral pallidal stimulation is a beneficial therapeutic option for long-term relief of the disabling dystonia symptoms in Meige syndrome.
authors.affiliation: Parkinson's Disease and Dystonia Research Center, Tokushima University Hospital, Tokushima 770-8503, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Sako
authors.forename: Ryoma
authors.initials: R
authors.lastname: Morigaki
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Mizobuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ima
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Ushio
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
authors.forename: Satoshi
authors.initials: S
authors.lastname: Goto
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008297:Male; D008538:Meige Syndrome / Q000503:physiopathology* / Q000628:therapy*; D008875:Middle Aged; D016896:Treatment Outcome