title: Immune response to Aspergillus fumigatus in compromised hosts: from bedside to bench.
abstract: The relevance of studies aimed at understanding host immune response against Aspergillus fumigatus takes on much significance given that all patients with invasive aspergillosis are invariably immunocompromised. This article attempts to correlate relevant findings from recent experimental studies to clinical observations made by the physician at the bedside. It is hoped that the increased understanding of host-fungus immune interaction may pave the way for the development of new management strategies against this difficult-to-treat fungal disease.
authors.affiliation: Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. chailouis@hotmail.com
authors.forename: Louis Y A
authors.initials: LY
authors.lastname: Chai
authors.forename: Alieke G
authors.initials: AG
authors.lastname: Vonk
authors.forename: Bart-Jan
authors.initials: BJ
authors.lastname: Kullberg
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology*; D016207:Cytokines; D006801:Humans; D007113:Immunity, Innate; D016867:Immunocompromised Host; D009894:Opportunistic Infections / Q000188:drug therapy / Q000276:immunology; D010586:Phagocytes; D012307:Risk Factors
chemical_list: D000935:Antifungal Agents; D016207:Cytokines