title: [Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method].
abstract: Using furosemide (FU) as a model drug, we examined the wet granulation method as a way to improve the taste masking and physical characteristics of orally disintegrating tablets (ODTs). In the wet granulation method, yogurt powder (YO) was used as a corrective and maltitol (MA) was used as a binding agent. The taste masked FU tablets were prepared using the direct compression method. Microcrystalline cellulose (Avicel® PH-302) and mannitol were added as excipients at a mixing ratio of 1/1 by weight. Based on the results of sensory test on taste, the prepared granules markedly improved the taste of FU, and a sufficient masking effect was obtained at the YO/FU ratio of 1 or more. Furthermore, it was found that the masking effect achieved by YO granules made with the wet granulation method was similar to or better than that produced by the granules made with dry granulation method. All types of tablets displayed sufficient hardness (over 3.5×10(-2) kN), and rapidly disintegrating tablets were obtained with YO granules produced at a mixing ratio of FU/YO=1/1, which disintegrated within 20 s. Disintegration time lengthened as the mixing ratio of YO to FU increased. In the mixing ratio of FU/YO=1/1, the hardness of tablets with granules made by the wet granulation method exceeded that of tablets with granules made by the dry granulation method, with minimal differences in disintegration time. The hardness and disintegration time of the tablets with granules made by the wet granulation method could be controlled by varying the compression force. In conclusion, YO was found to be a useful additive for masking unpleasant tastes. FU ODTs with improved taste, rapid disintegration and greater hardness could be prepared with YO-containing granules made by the wet granulation method using MA as a binding agent.
authors.affiliation: Department of Drug Delivery Research, Hoshi University, Tokyo, Japan. y.kawano@pha.twmu.ac.jp
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kawano
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ito
authors.forename: Masanaho
authors.initials: M
authors.lastname: Sasatsu
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Machida
authors.forename: Hiraku
authors.initials: H
authors.lastname: Onishi
mesh_terms: D000328:Adult; D002482:Cellulose; D004339:Drug Compounding / Q000379:methods*; D005079:Excipients; D005260:Female; D005665:Furosemide; D006244:Hardness; D006801:Humans; D008297:Male; D008353:Mannitol; D011208:Powders; D012995:Solubility; D013607:Tablets; D013649:Taste / Q000502:physiology; D015014:Yogurt
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets; D008353:Mannitol; D005665:Furosemide; D002482:Cellulose; C109691:microcrystalline cellulose