title: [The effect of ischemic preconditioning on adenosine phosphate content after spinal cord ischemia in rabbits].
abstract: OBJECTIVE
  To study the effect of ischemic preconditioning (IP) on adenosine phosphate content after spinal cord ischemia in rabbits.
  
  
  METHODS
  We established a lumbar spinal cord ischemia model by inflating the balloon of a 4F Swan-Ganz catheter positioned in the abdominal aorta of the rabbits. All rabbits were divided into sham-operated group, ischemic group and IP group. Adenosine phosphate content in spinal cord of all rabbits was determined at 4 hours, 2 days and 5 days after spinal cord ischemia by using reverse phase HPLC.
  
  
  RESULTS
  ATP content in lumbar spinal cord of rabbits in ischemic group was markedly reduced (P < 0.01 vs sham-operated group). But in IP group, it was obviously elevated at each time point compared with ischemic group (P < 0.01).
  
  
  CONCLUSIONS
  IP can significantly elevated ATP content in postischemic lumbar spinal cord in rabbits. This may be one of the mechanisms that IP can protect spinal cord from ischemic injury.
authors.affiliation: Department of Cardiovascular Surgery, Beijing 100853, China.
authors.forename: G
authors.initials: G
authors.lastname: Meng
authors.forename: L B
authors.initials: LB
authors.lastname: Zhu
authors.forename: Y F
authors.initials: YF
authors.lastname: Yu
authors.forename: J
authors.initials: J
authors.lastname: Liao
authors.forename: Y L
authors.initials: YL
authors.lastname: Zhao
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D019194:Ischemic Preconditioning; D008297:Male; D011817:Rabbits; D015424:Reperfusion; D013116:Spinal Cord / Q000378:metabolism; D020760:Spinal Cord Ischemia / Q000378:metabolism*
chemical_list: D000227:Adenine Nucleotides