title: The efficacy and safety of levobupivacaine administered by lumbosacral epidural route in conscious sheep.
abstract: The aim of this study was to evaluate 3 doses of levobupivacaine (LB) epidurally administered in sheep. Six adult male 24-36 month-old sheep received levobupivacaine at 3 doses, LB05 (0.05 mg/kg), LB15 (0.15 mg/kg), and LB25 (0.25mg/kg), and saline solution into the lumbosacral epidural space. Heart rate, arterial blood pressure (systolic, diastolic, and mean), respiratory rate, rectal, and skin temperature, local anesthesia, and ataxia were determined before treatment and at predetermined intervals. The duration of local anesthesia was 30±5 min, 145±27 min, and 290±18 min for LB05, LB15, and LB25, respectively (P<0.05). Ataxia determined for LB05, LB15, or LB25 was similar to the anesthetic times. There was an increase in heart rate and reduction in arterial pressure in LB25 (P<0.05), whereas LB05 or LB15 did not affect these parameters. Lumbosacral epidural levobupivacaine is an appropriate choice for local anesthesia in sheep.
authors.affiliation: Department of Veterinary Medicine, Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil. derossi@nin.ufms.br
authors.forename: Rafael
authors.initials: R
authors.lastname: DeRossi
authors.forename: Amadeu B
authors.initials: AB
authors.lastname: Silva-Neto
authors.forename: Cassio T D
authors.initials: CT
authors.lastname: Pompermeyer
authors.forename: Fabrício O
authors.initials: FO
authors.lastname: Frazílio
authors.forename: Paulo H A
authors.initials: PH
authors.lastname: Jardim
authors.forename: Andrea C L
authors.initials: AC
authors.lastname: de Barros
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007268:Injections, Epidural / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D000077554:Levobupivacaine; D008161:Lumbosacral Region; D008297:Male; D056152:Respiratory Rate / Q000187:drug effects; D012756:Sheep; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D000077554:Levobupivacaine; D002045:Bupivacaine