title: Cell-derived microparticles in the pathogenesis of cardiovascular disease: friend or foe?
abstract: Microparticles are ascribed important roles in coagulation, inflammation, and endothelial function. These processes are mandatory to safeguard the integrity of the organism, and their derangements contribute to the development of atherosclerosis and cardiovascular disease. More recently, the presumed solely harmful role of microparticles has been challenged because microparticles may also be involved in the maintenance and preservation of cellular homeostasis and in promoting defense mechanisms. Here, we summarize recent studies revealing these 2 faces of microparticles in cardiovascular disease.
authors.affiliation: Department of Clinical Chemistry, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. r.nieuwland@amc.uva.nl
authors.forename: Maarten E
authors.initials: ME
authors.lastname: Tushuizen
authors.forename: Michaela
authors.initials: M
authors.lastname: Diamant
authors.forename: Augueste
authors.initials: A
authors.lastname: Sturk
authors.forename: Rienk
authors.initials: R
authors.lastname: Nieuwland
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators