title: Neuroglial and synaptic rearrangements associated with photic entrainment of the circadian clock in the suprachiasmatic nucleus.
abstract: Rhythmic biological functions in mammals are orchestrated by a circadian timekeeper in the suprachiasmatic nucleus of the hypothalamus (SCN) which precisely adjusts clock outputs to solar time through the process of photic synchronization. Entrainment to the 24-h light-dark cycle is known to act on the molecular loops which trigger circadian oscillations but is also thought to involve day-night adjustments in the intercellular phasing of the multiple component SCN oscillators. This view is supported by data showing that the SCN undergoes important rearrangements of its neuroglial architecture throughout the 24-h cycle. The present paper highlights our data showing in rat that the two main sources of SCN efferents, composed of neurons synthesizing either vasopressin (AVP) or vasoactive intestinal peptide (VIP), are differentially involved in day-night SCN neuroglial plasticity. We found that the synaptic inputs received by the VIP neurons, which are major integrators of photic signals in the retinorecipient SCN subregion, increased during the day while those received by the AVP neurons remained unchanged at day and night. Glutamatergic axons, known to convey photic information from the retina, together with nonglutamatergic axons, contribute to the synaptic remodellings on VIP neurons. Experimental data providing strong indication that these plastic events may subserve synchronization of the clock to the light-dark cycle and that the daily fluctuations of plasma glucocorticoid hormones may act as temporal endocrine signals that may modulate SCN neuroglial plasticity through the rhythmic release of serotonin are also reviewed.
authors.affiliation: Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2M), CNRS-UMR 6231, Université de la Méditerranée, Marseille, France.
authors.forename: Clémence
authors.initials: C
authors.lastname: Girardet
authors.forename: Denis
authors.initials: D
authors.lastname: Becquet
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Blanchard
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: François-Bellan
authors.forename: Olivier
authors.initials: O
authors.lastname: Bosler
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D005938:Glucocorticoids / Q000097:blood; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010775:Photic Stimulation; D013493:Suprachiasmatic Nucleus / Q000166:cytology* / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D001127:Arginine Vasopressin; D014660:Vasoactive Intestinal Peptide