title: Prevalence and patient characteristics associated with CIN 3 in adolescents.
abstract: OBJECTIVE
  We sought to identify patient characteristics associated with cervical intraepithelial neoplasia (CIN) 3 in adolescents.
  
  
  METHODS
  A cross-sectional cohort study was done using a colposcopic database. Data collected included demographic and clinical information as well as cytologic and histologic results. Variables associated with CIN 3 in the univariable analysis (P ≤ .10) were included in a multivariable logistic regression model.
  
  
  RESULTS
  Of 614 adolescents evaluated, 48 (8%; 95% confidence interval, 6-10%) had CIN 3. No cancers were detected. In the univariable analysis, parity, ≥ 4 lifetime male sexual partners, and a history of sexually transmitted infections were associated with an increased risk of CIN 3. In the final model, only ≥ 4 sexual partners (compared to <4; adjusted odds ratio, 3.66; 95% confidence interval, 1.26-10.61) was significantly associated with the finding of CIN 3.
  
  
  CONCLUSIONS
  CIN 3 was infrequently encountered in adolescents, and those with multiple sexual partners were at increased risk for CIN 3.
authors.affiliation: Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island and the Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Aine E
authors.initials: AE
authors.lastname: Clements
authors.forename: Christina A
authors.initials: CA
authors.lastname: Raker
authors.forename: Amy S
authors.initials: AS
authors.lastname: Cooper
authors.forename: Lori A
authors.initials: LA
authors.lastname: Boardman
mesh_terms: D000293:Adolescent; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012747:Sexual Partners; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology