title: Internal carotid artery dissection and ischemic cerebral infarction in the setting of essential thrombocythemia.
abstract: Cervical artery dissection (CAD) is an important etiology of stroke in young adults. Its etiology is incompletely understood. Here, we report a young woman who presented with acute ischemic stroke in the setting of internal carotid artery (ICA) dissection and essential thrombocythemia (ET). We present a review of previous cases with comorbidity of CAD and ET and discuss the pathophysiological implications of this co-occurrence. In particular, we speculate that ET may increase the susceptibility of cervical vessels to spontaneous dissection, for example, by disturbing the microcirculation within the vessel wall.
authors.affiliation: Department of Neurology, Ludwig-Maximilians-Universität, Klinikum Großhadern, Munich, Germany. tobias.freilinger@med.uni-muenchen.de
authors.forename: T
authors.initials: T
authors.lastname: Freilinger
authors.forename: T
authors.initials: T
authors.lastname: Saam
authors.forename: M
authors.initials: M
authors.lastname: Duering
authors.forename: M
authors.initials: M
authors.lastname: Dichgans
authors.forename: N
authors.initials: N
authors.lastname: Peters
mesh_terms: D000328:Adult; D020215:Carotid Artery, Internal, Dissection / Q000097:blood*; D002544:Cerebral Infarction / Q000097:blood*; D005260:Female; D006801:Humans; D013920:Thrombocythemia, Essential / Q000150:complications*