title: Haemophagocytic syndrome and rickettsial diseases.
abstract: Haemophagocytic lymphohistiocytosis is a rare but potentially fatal disease resulting from dysregulated activation and proliferation of lymphocytes. We present a case of haemophagocytic syndrome occurring in a 5-year-old Italian boy as a complication of Mediterranean spotted fever. The characteristics of this case have been analysed and contextualized among those of another 15 cases of haemophagocytic syndrome associated with rickettsial diseases found through a systematic review of the international literature.
authors.affiliation: AILMI (Associazione Italiana per la Lotta contro le Malattie infettive) Universitï¿½ di Messina, Messina, Italy.|Dipartimento di Patologia Umana, Università di Messina, Messina, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cascio
authors.affiliation: Unità Operativa Complessa Malattie Infettive, ARNAS 'Civico, Di Cristina, Benfratelli', Palermo, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Giordano
authors.affiliation: Unità Operativa Complessa Malattie Infettive, ARNAS 'Civico, Di Cristina, Benfratelli', Palermo, Italy.
authors.forename: Piera
authors.initials: P
authors.lastname: Dones
authors.affiliation: Unità Operativa Complessa Oncoematologia Pediatrica, ARNAS 'Civico, Di Cristina, Benfratelli', Palermo, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Venezia
authors.affiliation: Dipartimento di Malattie Infettive e Tropicali, Università 'La Sapienza', Roma, Italy.|AILMI (Associazione Italiana per la Lotta contro le Malattie infettive) Universitï¿½ di Messina, Messina, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Iaria
authors.affiliation: Unità Operativa Complessa Oncoematologia Pediatrica, ARNAS 'Civico, Di Cristina, Benfratelli', Palermo, Italy.
authors.forename: Ottavio
authors.initials: O
authors.lastname: Ziino
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001907:Boutonneuse Fever / Q000150:complications* / Q000188:drug therapy; D002675:Child, Preschool; D006801:Humans; D007558:Italy; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents