title: [Mechanism of changes in intestinal epithelium permeability and its countermeasure after burn injury].
abstract: After a series of studies, we found that the intestinal permeability was increased, tight junction protein (zonula occluden-1) obviously decreased and redistributed, accompanied by an increase in expression of myosin light chain (MLC) phosphorylation in severely burned rats. After using inhibitor of MLC kinase (ML-9 2 mg/kg) or of Rho-associated kinase (Y-27632 2 mg/kg), above-mentioned changes could be alleviated. Therefore, to regulate the MLC phosphorylation of tight junction protein and perijunctional actin-myosin ring may be one of the key links to lessen the intestinal epithelium permeability after burn injury.
authors.affiliation: Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, China.
authors.forename: Shi-liang
authors.initials: SL
authors.lastname: Wang
mesh_terms: D000818:Animals; D002056:Burns / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D018994:Myosin Light Chains / Q000378:metabolism; D010539:Permeability; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D062826:Zonula Occludens-1 Protein; D054460:rho-Associated Kinases / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D018994:Myosin Light Chains; D010750:Phosphoproteins; C569044:Tjp1 protein, rat; D062826:Zonula Occludens-1 Protein; D054460:rho-Associated Kinases