title: Fatigue in colchicine myopathy: a study of transcranial magnetic stimulation.
abstract: BACKGROUND
  Transcranial magnetic stimulation (TMS) is a noninvasive method to assess brain physiology and plasticity. TMS has shown that nervous system excitability may be altered in myopathy, and it presents with motor disinhibition on cortical and subcortical levels. Eight patients who had colchicine myopathy were observed to have fatigue, but they did not have significant weakness. This study investigated whether there was central reorganization to compensate for their muscle strength.
  
  
  METHODS
  TMS was applied to study the central compensative mechanism. The TMS parameters included motor evoked potentials, central conduction time, cortical silent period and intracortical inhibition of paired TMS paradigms.
  
  
  RESULTS
  TMS results did not show any significant differences between patient and control groups.
  
  
  CONCLUSIONS
  Although central reorganization may occur in patients with hereditary myopathy to compensate for muscular strength, our study did not find any change in cortical excitabilities in acquired myopathy due to colchicine. Muscle fatigue may precede weakness as an early symptom of myopathy.
authors.affiliation: Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
authors.forename: Kon-Ping
authors.initials: KP
authors.lastname: Lin
authors.forename: Yang-Ching
authors.initials: YC
authors.lastname: Lo
authors.forename: Chia-Yi
authors.initials: CY
authors.lastname: Lin
authors.forename: Jen-Tse
authors.initials: JT
authors.lastname: Chen
authors.forename: Yung-Yang
authors.initials: YY
authors.lastname: Lin
authors.forename: Yi-Chung
authors.initials: YC
authors.lastname: Lee
authors.forename: Kwong-Kum
authors.initials: KK
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D003078:Colchicine / Q000009:adverse effects*; D005221:Fatigue / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation
chemical_list: D003078:Colchicine