title: Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder.
abstract: Convergent studies have implicated white matter abnormalities in the pathophysiology of major depressive disorder (MDD). In this study, diffusion tensor imaging (DTI) was used to examine white matter abnormalities in 23 single-episode, medication-naive MDD participants versus 21 healthy control participants. Voxel-based analysis was used to investigate whole brain white matter abnormalities in the MDD group. Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group.
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Tang
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Lingtao
authors.initials: L
authors.lastname: Kong
authors.forename: Wenge
authors.initials: W
authors.lastname: Sun
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Dongyan
authors.initials: D
authors.lastname: Kong
authors.forename: Yanliang
authors.initials: Y
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D003865:Major Depressive Disorder / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D018709:Statistics, Nonparametric; D055815:Young Adult