title: Desmopressin is an effective treatment for mixed nocturia with nocturnal polyuria and decreased nocturnal bladder capacity.
abstract: To investigate the efficacy and safety of desmopressin in patients with mixed nocturia, Patients aged ≥ 18 yr with mixed nocturia (≥ 2 voids/night and a nocturnal polyuria index [NPi] >33% and a nocturnal bladder capacity index [NBCi] >1) were recruited. The optimum dose of oral desmopressin was determined during a 3-week dose-titration period and the determined dose was maintained for 4 weeks. The efficacy was assessed by the frequency-volume charts and the sleep questionnaire. The primary endpoint was the proportion of patients with a 50% or greater reduction in the number of nocturnal voids (NV) compared with baseline. Among 103 patients enrolled, 94 (79 men and 15 women) were included in the analysis. The proportion of patients with a 50% or greater reduction in NV was 68 (72%). The mean number of NV decreased significantly (3.20 to 1.34) and the mean nocturnal urine volume, nocturia index, NPi, and NBCi decreased significantly. The mean duration of sleep until the first NV was prolonged from 118.4 ± 44.1 to 220.3 ± 90.7 min (P<0.001). The overall impression of patients about their quality of sleep improved. Adverse events occurred in 6 patients, including one asymptomatic hyponatremia. Desmopressin is an effective and well-tolerated treatment for mixed nocturia.
authors.affiliation: Department of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.forename: Myung-Soo
authors.initials: MS
authors.lastname: Choo
authors.forename: Jeong Gu
authors.initials: JG
authors.lastname: Lee
authors.forename: Choal Hee
authors.initials: CH
authors.lastname: Park
authors.forename: Jae-Seung
authors.initials: JS
authors.lastname: Paick
authors.forename: Jeong Zoo
authors.initials: JZ
authors.lastname: Lee
authors.forename: Deok Hyun
authors.initials: DH
authors.lastname: Han
authors.forename: Won Hee
authors.initials: WH
authors.lastname: Park
authors.forename: Kyu-Sung
authors.initials: KS
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050034:Antidiuretic Agents / Q000008:administration & dosage*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000150:complications / Q000188:drug therapy*; D011141:Polyuria / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D011795:Surveys and Questionnaires; D001743:Urinary Bladder / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin