title: Antiviral activity of Anaferon (pediatric formulation) in mice infected with pandemic influenza virus A(H1N1/09).
abstract: Anaferon (pediatric formulation) administered in the therapeutic-and-prophylactic regimen to mice receiving intranasally 100% infecting dose of A/California/07/2009(H1N1)v influenza virus exhibited an antiviral effect and 10-fold reduced the production of influenza virus in the lungs of infected mice on days 4, 6, and 8 after infection compared to the control (distilled water). The efficiency of Anaferon (pediatric formulation) administered before and after infection with A/California/07/2009(H1N1)v influenza virus was not inferior to the use of Tamiflu after infection.
authors.affiliation: Vector Research Center of Virology and Biotechnology, Federal Service on Surveillance for Consumer Rights Protection and Human WellBeing, Kol'tsovo, Novosibirsk Region, Russia. shish@vector.nsc.ru
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: M O
authors.initials: MO
authors.lastname: Skarnovich
authors.forename: A S
authors.initials: AS
authors.lastname: Kabanov
authors.forename: A A
authors.initials: AA
authors.lastname: Sergeev
authors.forename: S E
authors.initials: SE
authors.lastname: Olkin
authors.forename: S A
authors.initials: SA
authors.lastname: Tarasov
authors.forename: M V
authors.initials: MV
authors.lastname: Belopolskaya
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: E M
authors.initials: EM
authors.lastname: Malkova
authors.forename: E A
authors.initials: EA
authors.lastname: Stavsky
authors.forename: I G
authors.initials: IG
authors.lastname: Drozdov
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D008168:Lung / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000821:virology; D053139:Oseltamivir / Q000627:therapeutic use
chemical_list: D000906:Antibodies; D000998:Antiviral Agents; C547732:anaferon; D053139:Oseltamivir