title: [Association between polymorphisms of HIF-1alpha, eNOS genes and individual variation in response to hypoxia training].
abstract: OBJECTIVE
  To investigated association between polymorphisms of HIF-1alpha, eNOS genes and individual variation in response to intermittent hypoxia training.
  
  
  METHODS
  41 health subjects, completed 4 weeks hypoxia training program (hypoxia exposure 10 h each day and 3 times hypoxia training each week), to observed the relationship between C1772T polymorphism in exon 12 of HIF-1alpha gene and 27-base pair(bp) variable number of tandem repeat polymorphism (VNTR), 4b/a, in intron 4 of eNOS gene and physiological parameters, such as VO2(max), Hb, RBC and SpaO2.
  
  
  RESULTS
  The results showed that the change of VO2(max) was higher in carriers with CT genotype than those of CC genotype, and the changes of Hb and RBC indicated higher tendency in the subjects carrying the CT genotype. Same results were observed in the changes of SpaO2 during period of exercising under hypoxic condition.
  
  
  CONCLUSIONS
  These findings suggested the possible associations between SNP/C1772T, VNTR/4ba and the individual variation in response to hypoxia training.
authors.affiliation: Department of Sports and Wenzhou Medical College, Wenzhou, 325035, China.
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010806:Physical Education and Training; D010807:Physical Endurance / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III