title: Contact sensitization in the elderly.
abstract: Contact dermatitis from irritant and allergic sources is the reason for 6% to 10% of all dermatologic visits with considerable morbidity and economic impact. Allergic contact dermatitis is a T-cell-mediated inflammatory reaction and develops in predisposed individuals as a consequence of environmental exposure to allergens. Aging is correlated with the rate and type of contact sensitization because of "immunosenescence." The number of old people is growing around the world. This contribution reviews the main findings from published epidemiologic studies on contact allergy in elderly populations. In all examined studies, patch testing was performed in patients with cutaneous manifestations possibly related to contact dermatitis; the prevalence of contact dermatitis in the elderly was from 33% to 64%. Establishing the most frequent allergens responsible for allergic contact dermatitis in the elderly is a hard task. The commonest allergens reported were nickel sulfate, fragrance mix, diamino diphenylmethane, lanolin alcohols, paraben mix, Euxyl K400, quinoline mix, and balsam of Peru. We emphasize that allergens surveillance is needed to realize an "elderly series" for having a useful adjunct to contact allergy that may help the treatment of each patient.
authors.affiliation: Department of Dermatology, University of Naples Federico II, via S. Pansini n.5, 80131 Naples, Italy. annabalato@yahoo.it
authors.forename: Anna
authors.initials: A
authors.lastname: Balato
authors.forename: Nicola
authors.initials: N
authors.lastname: Balato
authors.forename: Luisa
authors.initials: L
authors.lastname: Di Costanzo
authors.forename: Fabio
authors.initials: F
authors.lastname: Ayala
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007871:Leg Ulcer / Q000276:immunology; D015995:Prevalence
chemical_list: D000485:Allergens