title: Low-level laser therapy in burning mouth syndrome patients: a pilot study.
abstract: OBJECTIVE
  The aim of this study was to investigate the effect of low-level laser therapy (LLLT) on the treatment of burning mouth syndrome (BMS). In addition, the laser effect was compared on the different affected oral sites.
  
  
  METHODS
  Eleven subjects with a total of 25 sites (tongue, lower lip, upper lip, and palate) affected by a burning sensation were selected. The affected areas were irradiated once a week for three consecutive weeks with an infrared laser (λ = 790 nm). The probe was kept in contact with the tissue, and the mucosal surface was scanned during the irradiation. The exposure time was calculated based on the fluence of 6 J/cm(2), the output power of 120 mW, and the area to be treated. Burning intensity was recorded through a visual analog scale before and after the treatment and at the 6-week follow-up. The percentage of the improvement in symptoms was also obtained.
  
  
  RESULTS
  Burning intensity at the end of the laser therapy was statistically lower than at the beginning (p < 0.01). Patients reported an 80.4% reduction in the intensity of symptoms after laser treatment. There was no statistical difference between the end of the treatment and the 6-week follow-up, except for the tongue site.
  
  
  CONCLUSIONS
  Under the investigated parameters, infrared LLLT proved to be a valuable alternative for BMS treatment, providing a significant and lasting reduction in symptoms.
authors.affiliation: Centro de Lasers e Aplicações, Instituto de Pesquisas Energéticas e Nucleares-IPEN/CNEN-SP, Cidade Universitária, São Paulo, Brazil.
authors.forename: Ilka Tiemy
authors.initials: IT
authors.lastname: Kato
authors.forename: Vivian Diane
authors.initials: VD
authors.lastname: Pellegrini
authors.forename: Renato Araujo
authors.initials: RA
authors.lastname: Prates
authors.forename: Martha Simões
authors.initials: MS
authors.lastname: Ribeiro
authors.forename: Niklaus Ursus
authors.initials: NU
authors.lastname: Wetter
authors.forename: Norberto Nobuo
authors.initials: NN
authors.lastname: Sugaya
mesh_terms: D000328:Adult; D000368:Aged; D002054:Burning Mouth Syndrome / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010865:Pilot Projects