title: [Trauma-associated bleeding in the severely injured. Relevance, risk stratification and current therapy approaches].
abstract: Of all trauma-related deaths 40% are due to exsanguination. The causes for acute,  hemorrhaging are uncontrolled bleeding sources and the development of acute posttraumatic coagulopathy. Clinical observations and recent research results emphasize the key role of this disorder in acute trauma care. The present synopsis summarizes the results from different analyses based on datasets from severely injured patients derived from the Trauma Register of the German Trauma Society (DGU) on frequency, potential triggers and strategies to manage acute posttraumatic coagulopathy. In an extension to this work a clinical scoring system for early identification of patients at high risk for ongoing bleeding is presented. High risk patients seem to benefit from a more balanced transfusion regimen.
authors.affiliation: Klinik für Unfallchirurgie und Orthopädie, Kliniken der Stadt Köln gGmbH, Krankenhaus Köln-Merheim, Universitätsklinikum Witten-Herdecke, Standort Köln-Merheim, Ostmerheimerstrasse 200, Köln, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Peiniger
authors.forename: M
authors.initials: M
authors.lastname: Maegele
mesh_terms: D000465:Algorithms; D001778:Blood Coagulation Disorders / Q000145:classification / Q000401:mortality / Q000601:surgery*; D016913:Blood Component Transfusion; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D005260:Female; D005264:Femoral Fractures / Q000145:classification / Q000401:mortality / Q000601:surgery; D005597:Fractures, Open / Q000145:classification / Q000401:mortality / Q000601:surgery; D006465:Hemoperitoneum / Q000145:classification / Q000401:mortality / Q000601:surgery; D006470:Hemorrhage / Q000145:classification / Q000401:mortality / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D009104:Multiple Trauma / Q000145:classification / Q000401:mortality / Q000601:surgery*; D010384:Pelvic Bones / Q000293:injuries / Q000601:surgery; D012189:Retrospective Studies; D012737:Sex Factors; D012774:Shock, Traumatic / Q000150:complications / Q000401:mortality; D015996:Survival Rate