title: The value of recognizing suspect diagnoses in the triple diagnosis of giant cell tumor of bone.
abstract: Giant cell tumor (GCT) of bone is the most frequently over-diagnosed neoplasm in orthopedic pathology because giant cells are a common component of many neoplastic and nonneoplastic conditions of bone. Triple diagnosis, requiring substantial individual and collective inputs by orthopedic surgeons, radiologists and pathologists, is the preferred method for the workup of patients with suspected bone neoplasms. At each stage in triple diagnosis, deviations from the typical must be regarded as clues to alternate diagnoses: the greater the deviation, the more a diagnosis of GCT must be considered suspect. A suspect diagnosis must trigger renewed analysis of the available data and a diligent search to exclude alternate diagnoses.This review lists suspect diagnoses of GCT with a brief overview of each.
authors.affiliation: Department of Pathology, University College of Medical Sciences and GTB Hospital, Delhi - 110 095, India.
authors.forename: Mrinalini
authors.initials: M
authors.lastname: Kotru
authors.forename: Navjeevan
authors.initials: N
authors.lastname: Singh