title: Serum triglyceride concentrations in Miniature Schnauzers with and without a history of probable pancreatitis.
abstract: BACKGROUND
  The association between hypertriglyceridemia and pancreatitis remains obscure in dogs. A possible role of hypertriglyceridemia as a cause of pancreatitis in Miniature Schnauzers has been suspected.
  
  
  OBJECTIVE
  To compare serum triglyceride concentrations between Miniature Schnauzers with and without a recent history of pancreatitis.
  
  
  METHODS
  Seventeen Miniature Schnauzers with a history of pancreatitis (group 1) and 34 age-matched Miniature Schnauzers without a history of pancreatitis (group 2) were prospectively enrolled.
  
  
  METHODS
  Prospective case-control study. Two samples were collected from each of the 17 Miniature Schnauzers with pancreatitis: 1 during pancreatitis and 1 after clinical and biochemical resolution of pancreatitis. Serum triglyceride and cholesterol concentrations were compared between group 1 (after resolution of pancreatitis) and group 2.
  
  
  RESULTS
  Miniature Schnauzers in group 1 were significantly more likely to have hypertriglyceridemia (>108 mg/dL) (71%) after resolution of pancreatitis than Miniature Schnauzers in group 2 (33%; odds ratio = 5.02; 95% confidence interval = 1.4-17.8; P = .0163). Serum triglyceride concentrations were significantly higher in dogs of group 1 (median: 605.0 mg/dL) after resolution of pancreatitis than in dogs of group 2 (median: 73.5 mg/dL; P = .002).
  
  
  CONCLUSIONS
  Miniature Schnauzers with a history of pancreatitis were 5 times more likely to have hypertriglyceridemia than controls. Hypertriglyceridemia might be associated with the development of pancreatitis in some dogs of this breed. Additional studies are needed to further clarify the role of hypertriglyceridemia in the development of pancreatitis in Miniature Schnauzers as well as other dog breeds.
authors.affiliation: Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. pxenoulis@cvm.tamu.edu
authors.forename: P G
authors.initials: PG
authors.lastname: Xenoulis
authors.forename: M D
authors.initials: MD
authors.lastname: Levinski
authors.forename: J S
authors.initials: JS
authors.lastname: Suchodolski
authors.forename: J M
authors.initials: JM
authors.lastname: Steiner
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs / Q000097:blood*; D005260:Female; D015228:Hypertriglyceridemia / Q000097:blood / Q000662:veterinary*; D008297:Male; D010195:Pancreatitis / Q000097:blood* / Q000662:veterinary*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol