title: The effects of loss versus alteration of consciousness on inhibition-related brain activity among individuals with a history of blast-related concussion.
abstract: In this investigation, 27 individuals who experienced blast-related concussion, i.e., brief loss (LOC) or alteration (AOC) of consciousness, performed a stop task during functional magnetic resonance imaging. LOC versus AOC subjects displayed altered ventromedial prefrontal cortex activity, which correlated with somatic symptom severity-findings which may suggest a neural correlate of impaired self awareness after LOC.
authors.affiliation: Department of Psychiatry, University of California San Diego, CA, USA. scmatthews@ucsd.edu
authors.forename: Scott
authors.initials: S
authors.lastname: Matthews
authors.forename: Alan
authors.initials: A
authors.lastname: Simmons
authors.forename: Irina
authors.initials: I
authors.lastname: Strigo
mesh_terms: D000328:Adult; D001753:Blast Injuries / Q000150:complications; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001924:Brain Concussion / Q000209:etiology / Q000473:pathology*; D001931:Brain Mapping; D000077463:Carbamide Peroxide; D003243:Consciousness / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009010:Monte Carlo Method; D010545:Peroxides / Q000097:blood; D014474:Unconsciousness / Q000473:pathology / Q000503:physiopathology*; D014508:Urea / Q000031:analogs & derivatives / Q000097:blood; D055815:Young Adult
chemical_list: D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea