title: Anti-oxidative effect of lipoic Acid in spinal cord ischemia/reperfusion.
abstract: OBJECTIVE
  Lipoic acid (LA) is an effective anti-oxidant agent that can scavenge free radicals in biological systems. The aim of this research was to study the probable protective effect of LA in spinal ischemic/reperfusion (I/R) injury.
  
  
  METHODS
  Thirty male Wistar rats, weighing 230-285 g, were assigned randomly into 3 groups (10 animals in each group): sham spinal I/R, and spinal I/R + LA. The spinal I/R + LA rats received LA 100 mg/kg subcutaneously 3 days prior to ischemia induction and 3 days after. The induction of ischemia lasted for 30 min.
  
  
  RESULTS
  At 72 h postoperatively, the neurological status was worse in the I/R group than the sham group (p < 0.05). The neurological status of animals in the LA-treated group appeared better than the I/R group (p < 0.05). In the I/R group, tissue glutathione peroxidase (GPx) and super oxide dismutase (SOD) activity were significantly less compared to the control group (p < 0.05). In the LA-treated group, tissue GPx and SOD levels were higher compared to the I/R group (p < 0.05).
  
  
  CONCLUSIONS
  LA pretreatment reduced neurologic injury in the rats, most probably by maintaining the oxidant/anti-oxidant ion balance during spinal cord ischemia. Reperfusion may have contributed to the protective effects seen in the LA pretreatment.
authors.affiliation: Neuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sheyda
authors.initials: S
authors.lastname: Shaafi
authors.forename: Mohammad Razm
authors.initials: MR
authors.lastname: Afrooz
authors.forename: Babak
authors.initials: B
authors.lastname: Hajipour
authors.forename: Alireza
authors.initials: A
authors.lastname: Dadadshi
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Hosseinian
authors.forename: Ali
authors.initials: A
authors.lastname: Khodadadi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion; D020760:Spinal Cord Ischemia / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000032:analysis; D008063:Thioctic Acid / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D008063:Thioctic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase