title: Nanocytology: a novel class of biomarkers for cancer management.
abstract: Recently, cellular mechanical properties have received increasing attention as a potential biophysical marker for cancer cells. The analysis of mechanical profiles at the single-cell level may provide information that is potentially useful to assess tumor prognosis and response to therapy. This feature review discusses a novel nanocytology approach that combines traditional morphology assessment, molecular analysis and nanomechanical analysis of cancer cells.
authors.affiliation: Edeixa LLC, Marketing and Product Development, 28723 Colina Vista, Agoura Hills, CA 91301, USA.
authors.forename: Lorance
authors.initials: L
authors.lastname: Wilson
authors.forename: Sarah
authors.initials: S
authors.lastname: Cross
authors.forename: James
authors.initials: J
authors.lastname: Gimzewski
authors.forename: JianYu
authors.initials: J
authors.lastname: Rao
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001696:Biomechanical Phenomena; D002448:Cell Adhesion; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D018625:Microscopy, Atomic Force; D016252:Microscopy, Scanning Tunneling; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D059010:Single-Cell Analysis / Q000379:methods*
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor