title: Plasma long-chain fatty acids profile and metabolic outcomes in normolipidaemic obese children after one-year nutritional intervention.
abstract: OBJECTIVE
  To assess the association between changes in plasma long-chain polyunsaturated fatty acids (LCPUFAs) profile and metabolic outcomes after 1-year nutritional intervention in normolipidaemic obese children.
  
  
  METHODS
  Fifty-seven normolipidaemic obese children, aged 8-13 years, were recruited in the study. Body mass index (BMI) z-scores were calculated. Fasting blood samples were analysed for insulin, glucose, lipid profile and fatty acid (FA) levels at baseline and after an 1-year nutritional-behaviour intervention. Insulin resistance was estimated by homeostatic model assessment (HOMA).
  
  
  RESULTS
  Fifty-one obese children completed the study. At the end of the intervention, the children showed decreased BMI z-score (mean reduction 0.25; 95% confidence interval [CI], 0.18-0.31), HOMA index (1.6; 0.6-2.5), plasma-saturated FA (1.49; 0.67-2.31 mg/dL), C20:3n-9 (0.05; 0.02-0.07 mg/dL) and increased plasma levels of monounsaturated FA (mean increase 1.35; 0.63-2.07 mg/dL), n-6 PUFA (1.02; 0.08-1.97 mg/dL), n-3 PUFA (0.24; 0.07-0.40 mg/dL), C20:4n-6 (0.37; 0.11-0.63 mg/dL), C18:3n-3 (0.04; 0.01-0.07 mg/dL), C22:6n-3 (0.30; 0.17-0.42 mg/dL) and the C22:6n-3/C20:4n-6 ratio (0.02; 0.01-0.03 mg/dL) ratio.
  
  
  CONCLUSIONS
  Nutritional interventions may improve plasma LCPUFA profile and metabolic outcomes of normolipidaemic obese children.
authors.affiliation: Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy. elvira.verduci@unimi.it
authors.forename: Elvira
authors.initials: E
authors.lastname: Verduci
authors.forename: Giovanni
authors.initials: G
authors.lastname: Radaelli
authors.forename: Michela
authors.initials: M
authors.lastname: Salvioni
authors.forename: Enrica
authors.initials: E
authors.lastname: Riva
authors.forename: Marcello
authors.initials: M
authors.lastname: Giovannini
mesh_terms: D000293:Adolescent; D001521:Behavior Therapy / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D018752:Diet, Fat-Restricted / Q000379:methods*; D005227:Fatty Acids / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood* / Q000737:chemistry; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D007328:Insulin; D008055:Lipids