title: A rabbit bone tumor model for high-intensity focused ultrasound therapy.
abstract: The incidence of malignant bone tumor increases every year. Because the application of high-intensity focused ultrasound (HIFU) for the treatment of bone tumors is still at a nascent stage, it is essential to study the effectiveness of this technique in ideal animal models in order to obtain a beneficial reference for imaging studies. In this study, we established a VX2 malignant bone tumor model and evaluated this model by contrast-enhanced sonography and magnetic resonance imaging (MRI). The results show that all tumors were enhanced after injection of SonoVue. A contrast-enhanced MRI scan revealed obvious enhancement within the tumors. Histological examination revealed the presence of a large number of tumor cells. The model can serve as an ideal experimental model for the study of HIFU therapy in the treatment of malignant bone tumors and as a reference for imaging studies during follow-ups.
authors.affiliation: Department of Ultrasound in Medicine, Shanghai tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wu
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Kuang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Ma
authors.forename: Bu-Lin
authors.initials: BL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology / Q000628:therapy*; D003287:Contrast Media; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D011817:Rabbits
chemical_list: D003287:Contrast Media