title: Carcinogenic potential, levels and sources of polycyclic aromatic hydrocarbon mixtures in indoor and outdoor environments and their implications for air quality standards.
abstract: Both the World Health Organization and the UK Expert Panel on Air Quality Standards (EPAQS) have considered benzo(a)pyrene (BaP) as a marker of the carcinogenic potency of the polycyclic aromatic hydrocarbons (PAH) mixture, when recommending their respective guidelines for PAHs in outdoor air. The aim of this research is to compare the concentrations and relative abundance of individual PAH and their contribution to the overall carcinogenic potential of the PAH mixture in indoor and outdoor environments to assess the suitability of the UK air quality standard derived for outdoor air for use as a guideline for indoor environments. Samples were collected onto filters using active sampling in different indoor and outdoor microenvironments. The ratio of individual compounds to BaP, the BaP equivalent concentrations and the percentage contribution of each individual compound to the total carcinogenic potential of the PAH mixture were calculated. Mean concentrations were generally lower indoors (BaP=0.10 ng/m(3)) than outdoors (BaP=0.19 ng/m(3)), with the exception of indoor environments with wood burners (BaP=2.4 ng/m(3)) or ETS (BaP=0.6 ng/m(3)). The ratio of individual PAHs to BaP showed no significant differences between indoors (e.g. DahA/BaP=0.27) and outdoors (DahA/BaP=0.31). The relative contribution of BaP to the PAH overall carcinogenic potency is similar indoors (49%), outdoors (54%) and in the smelter environment (48%) used by EPAQS to derive the UK Air Quality Standard for ambient air. These results suggest the suitability of BaP as a marker for the carcinogenic potential of the PAH mixture irrespective of the environment. Despite small differences in PAH mixture composition indoors and outdoors, the level of protection afforded by the present EPAQS standard is likely to be similar whether it is applied to indoor or outdoor air.
authors.affiliation: Division of Environmental Health & Risk Management, School of Geography, Earth & Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Juana Maria
authors.initials: JM
authors.lastname: Delgado-Saborit
authors.forename: Christopher
authors.initials: C
authors.lastname: Stark
authors.forename: Roy M
authors.initials: RM
authors.lastname: Harrison
mesh_terms: D000393:Air Pollutants / Q000032:analysis* / Q000592:standards / Q000633:toxicity; D016902:Air Pollution, Indoor / Q000032:analysis* / Q000706:statistics & numerical data; D001564:Benzo(a)pyrene / Q000032:analysis / Q000592:standards / Q000633:toxicity; D002274:Carcinogens, Environmental / Q000032:analysis / Q000592:standards / Q000633:toxicity; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis* / Q000592:standards / Q000633:toxicity; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000393:Air Pollutants; D002274:Carcinogens, Environmental; D011084:Polycyclic Aromatic Hydrocarbons; D001564:Benzo(a)pyrene