title: Effect of phenol inducing the antioxidant responsive element on Drosophila melanogaster lifespan.
abstract: The effect of hydrophilic synthetic antioxidant TC-13 (3-(3'-tert-butyl-4'-hydroxyphenyl)propylthiosulfonate sodium) inducing the antioxidant-responsive element on the lifespan of Drosophila melanogaster was studied. Addition of 1% TC-13 to diets prolonged the lifespan of long-lived D. melanogaster Canton S strain females and males, but not of short-lived Oregon R insects and reduced the mean lifespan of D. melanogaster males of the lgl558OR/Cy strain containing a recessive lethal mutation of tumor suppressor in the heterozygotic state. The geroprotective effects of TC-13 synthetic phenol antioxidant depended on D. melanogaster genotype and gender.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. lemen@soramn.ru
authors.forename: E B
authors.initials: EB
authors.lastname: Menshchikova
authors.forename: N K
authors.initials: NK
authors.lastname: Zenkov
authors.forename: N Ya
authors.initials: NY
authors.lastname: Weisman
authors.forename: N V
authors.initials: NV
authors.lastname: Kandalintseva
authors.forename: A E
authors.initials: AE
authors.lastname: Prosenko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005838:Genotype; D008136:Longevity / Q000187:drug effects* / Q000235:genetics; D008297:Male; D015394:Molecular Structure; D019800:Phenol / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012737:Sex Factors
chemical_list: D000975:Antioxidants; D019800:Phenol