title: Low frequency of HIV-1 tropism evolution in patients successfully treated for at least 2 years.
abstract: The aim of this study was to analyse tropism evolution in HIV-1 patients with at least 2 years of viral load undetectability. For this purpose, HIV-1-infected antiretroviral-treated patients (n = 128) with a viral load less than 50 copies/ml for 4 years in median were studied. No change of virus tropism was observed in 92.9% of patients. Therefore, before the use of CCR5 antagonists, genotypic viral DNA tropism determination is an available tool.
authors.affiliation: Université Pierre et Marie Curie-Paris, UMR S, France. cathia.soulie@psl.aphp.fr
authors.forename: Cathia
authors.initials: C
authors.lastname: Soulie
authors.forename: Sidonie
authors.initials: S
authors.lastname: Lambert-Niclot
authors.forename: Marc
authors.initials: M
authors.lastname: Wirden
authors.forename: Anne
authors.initials: A
authors.lastname: Simon
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Valantin
authors.forename: Slim
authors.initials: S
authors.lastname: Fourati
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019713:Receptors, CCR5 / Q000235:genetics / Q000502:physiology*; D019562:Viral Load; D056189:Viral Tropism; D055815:Young Adult
chemical_list: D019713:Receptors, CCR5