title: Immunoreactivity of neuron-specific enolase (NSE) in human pancreas in health and type 1 diabetes mellitus.
abstract: The role of neuron-specific enolase (glycolytic enzyme; marker of nerve fibers and Langerhans islet in human pancreas) in the development of type 1 diabetes mellitus was studied in autopsy specimens from 6 adult patients. Autopsied specimens of the pancreas from 7 subjects without carbohydrate metabolism disorders served as the control. Autopsied specimens of the pancreas from a child with the clinical diagnosis of type 1 diabetes mellitus, a child without carbohydrate metabolism disorders, and from 7 human fetuses of 15-40 weeks gestation were also studied. In control specimens, the neuron-specific enolase was detected in the pancreatic nerve fibers and Langerhans islets. Studies of pancreatic tissue specimens from adult patients with type 1 diabetes mellitus showed no immunopositive reaction to neuron-specific enolase in insulin-negative specimens. A possible mechanism of type 1 diabetes mellitus development is suggested.
authors.affiliation: Institute of Human Morphology, the Russian Academy of Medical Sciences, Moscow, Russia. proschina@mtunet
authors.forename: A E
authors.initials: AE
authors.lastname: Proshchina
authors.forename: S V
authors.initials: SV
authors.lastname: Savelyev
authors.forename: V M
authors.initials: VM
authors.lastname: Barabanov
authors.forename: Yu S
authors.initials: YS
authors.lastname: Krivova
mesh_terms: D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000201:enzymology* / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*
chemical_list: D007328:Insulin; D010751:Phosphopyruvate Hydratase