title: Serum appearance of anti-p53 antibody in triple negative breast cancer.
abstract: BACKGROUND
  Significance of serum appearance of anti-p53 antibody in breast cancer has not been discussed fully.
  
  
  METHODS
  The relationship between serum appearance of anti-p53 antibody and the clinicopathological features was investigated on the basis of the data of 42 women with breast cancer who had been treated with surgical resection.
  
  
  RESULTS
  The proportion of tumors with histological grade 3 was significantly higher among tumors with serum appearance of anti-p53 antibody (P = 0.020). The proportion of triple negative tumors was also significantly higher among tumors with serum appearance of anti-p53 antibody (P = 0.003).
  
  
  CONCLUSIONS
  Preoperative appearance of anti-p53 antibody in sera can be correlated with the incidence of triple negative breast cancer and could therefore help identify tumors with aggressive potential.
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga, 811-3195, Japan. paper7777@yahoo.co.jp
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Nozoe
authors.forename: Emiko
authors.initials: E
authors.lastname: Mori
authors.forename: Mayuko
authors.initials: M
authors.lastname: Kono
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Maeda
authors.forename: Akito
authors.initials: A
authors.lastname: Matsukuma
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ezaki
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D017697:Premenopause; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000097:blood; D011980:Receptors, Progesterone / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000276:immunology* / Q000378:metabolism
chemical_list: D000906:Antibodies; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53; C495901:TP53 protein, human; C508053:ERBB2 protein, human