title: Association between sperm quality, oxidative stress, and seminal antioxidant activity.
abstract: OBJECTIVE
  To determine seminal antioxidant capacity, oxidative stress markers, and their association with semen quality as oxidative stress is considered to be a major etiological factor in male infertility.
  
  
  METHODS
  Semen samples were obtained from 138 men and categorized on the basis of sperm count, motility, and morphology. Seminal oxidative and antioxidant markers are as follows: lipid peroxidation (LPO), protein carbonyls (PC), superoxide dismutase (SOD), catalase (CAT), thiols, and ascorbic acid were determined.
  
  
  RESULTS
  Sperm count significantly correlated positively with progressive sperm motility and normal morphology. Sperm count and normal morphology showed significant negative correlation with LPO and PC. Sperm count and progressive motility showed significant positive relationship with SOD. The SOD, CAT, and thiols positively whereas LPO and PC negatively associated with elevated sperm count.
  
  
  CONCLUSIONS
  Insufficient antioxidant enzymes and increased oxidative stress may attribute to the risk of declining semen quality and hence protective role for antioxidant enzymes against the oxidative damage cannot be ruled out.
authors.affiliation: Division of Reproductive and Cytotoxicology, National Institute of Occupational Health (ICMR), Ahmedabad-380016, India.
authors.forename: Murarka
authors.initials: M
authors.lastname: Shiva
authors.forename: Anil K
authors.initials: AK
authors.lastname: Gautam
authors.forename: Yogendra
authors.initials: Y
authors.lastname: Verma
authors.forename: Vijay
authors.initials: V
authors.lastname: Shivgotra
authors.forename: Haresh
authors.initials: H
authors.lastname: Doshi
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000032:analysis; D002374:Catalase / Q000032:analysis; D015984:Causality; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism* / Q000503:physiopathology; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D050050:Protein Carbonylation; D055101:Semen Analysis; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000166:cytology* / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000032:analysis; D013482:Superoxide Dismutase / Q000032:analysis; D055815:Young Adult
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid