title: Vascular endothelial growth factor in gingival crevicular fluid around dental implants.
abstract: BACKGROUND
  Angiogenesis occurs under physiological and pathological conditions and is regulated by cytokines and growth factors. Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine that plays a significant role in inflammation and immune responses implicated in the pathogenesis of inflammatory processes in the implant- surrounding tissues.
  
  
  OBJECTIVE
  The study investigated the concentration of VEGF in gingival crevicular fluid (GCF) in healthy and diseased soft tissues surrounding implants.
  
  
  METHODS
  Clinical examinations were focused on assessing the periodontal status of soft tissues around dental implants with the use of Florida Probe. Bone loss was examined radiologically. VEGF concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA).
  
  
  RESULTS
  VEGF concentrations were found higher in crevicular fluid around implants than in clinically healthy sites. They were also strongly correlated with the pocket depth.
  
  
  CONCLUSIONS
  The presence of VEGF in gingival crevicular fluid in patients with peri-implants can be implicated in the progression of peri-implantitis, possibly by promoting the formation of new blood vessels during angiogenic processes.
authors.affiliation: Department of Prosthodontics, Warsaw Medical University, Warsaw, Poland. m_pokorski@hotmail.com
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Mierzwinska-Nastalska
authors.forename: L
authors.initials: L
authors.lastname: Lomzynski
authors.forename: M
authors.initials: M
authors.lastname: Jaworska-Zaremba
authors.forename: J
authors.initials: J
authors.lastname: Kostrzewa-Janicka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003773:Dental Plaque / Q000378:metabolism; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D057873:Peri-Implantitis / Q000209:etiology*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
chemical_list: D042461:Vascular Endothelial Growth Factor A