title: Anti-inflammatory potency of oral disulfiram compared with dexamethasone on endotoxin-induced uveitis in rats.
abstract: To investigate potency of oral disulfiram (DSF) compared with that of dexamethasone (Dexa), on endotoxin-induced uveitis (EIU) in rats. The oral administration with 750 mg/kg DSF suppressed the number of inflammatory cells, protein concentration, and levels of tumor necrosis factor (TNF)-α, Nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor and improved the histiologic status of the ocular tissue at 24 hr after lipopolysaccharide (LPS) injection. The anti-inflammatory potency of DSF oral administration was as strong as that observed with 0.5 mg/kg Dexa in the present study. The results suggest that DSF might pave the way for a novel therapeutic agent for the management of uveitis.
authors.affiliation: Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034–8628, Japan. kanai@vmas.kitasato-u.ac.jp
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kanai
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Itoh
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Ito
authors.forename: Noriaki
authors.initials: N
authors.lastname: Nagai
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Hori
authors.forename: Seishirou
authors.initials: S
authors.lastname: Chikazawa
authors.forename: Fumio
authors.initials: F
authors.lastname: Hoshi
authors.forename: Seiichi
authors.initials: S
authors.lastname: Higuchi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004221:Disulfiram / Q000008:administration & dosage / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000633:toxicity*; D051381:Rats; D011917:Rats, Inbred Lew; D014605:Uveitis / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D003907:Dexamethasone; D004221:Disulfiram