title: [Sustained electrical stimulation of Bötzinger complex on phrenic nerve discharges in rabbits].
abstract: OBJECTIVE
  To observe the effects of sustained electrical stimulation at Bötzinger complex (Böt. c) on phrenic nerve discharges.
  
  
  METHODS
  Sustained electrical stimulation (10--50 microA, 40-100 Hz, 0.3 ms, for 15-30 s) of Böt. C on 30 urethane anaesthetized, vagotomized, paralyzed and artificially ventilated rabbits.
  
  
  RESULTS
  Sustained electrical stimulation of Bot. C produced the inhibition or "inspiratory off-switch" of phrenic discharge during the stimulation. The inhibition of the phrenic discharges showed intensity and frequency dependence. Habituation was shown during the stimulation, showing the magnitude of the phrenic nerve discharge increased gradually. Post-stimulus rebound exhibited upon the cessation of the stimulation, showing the magnitude of the phrenic activity increased significantly. Short-term memory was shown in the habituation of the phrenic activity.
  
  
  CONCLUSIONS
  Non-associative learning is involved in the central control of respiratory modulation in the Böt. C and synaptic plasticity may exist in the respiratory neurons of Böt. C.
authors.affiliation: Institute of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
authors.forename: Gui-Min
authors.initials: GM
authors.lastname: Wang
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.forename: Shu-Yan
authors.initials: SY
authors.lastname: Yu
authors.forename: Fa-Yan
authors.initials: FY
authors.lastname: Zhang
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Cao
authors.forename: Gang
authors.initials: G
authors.lastname: Song
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005154:Facial Nerve / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology*; D011817:Rabbits