title: Cytotoxic amide alkaloids from Piper boehmeriaefolium.
abstract: Eight new amide alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC(50) value of 2.7 μg/mL.
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Chen
authors.forename: Bei-Ying
authors.initials: BY
authors.lastname: Qiu
authors.forename: Li
authors.initials: L
authors.lastname: Sheng
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Guang-Wan
authors.initials: GW
authors.lastname: Hu
authors.forename: Fu-Wei
authors.initials: FW
authors.lastname: Zhao
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Ma
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Qiao-Qin
authors.initials: QQ
authors.lastname: Huang
authors.forename: Jin-Jin
authors.initials: JJ
authors.lastname: Xu
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
authors.forename: Jia
authors.initials: J
authors.lastname: Li
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031701:Piper / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: C558042:1-((9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl)pyrrolidine; D000470:Alkaloids; D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011759:Pyrrolidines