title: [Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia].
abstract: OBJECTIVE
  To study the effect of aspirin on chronic hypoxia and hypercapnic pulmonary hypertension.
  
  
  METHODS
  SD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + aspirin group (C). The concentration of TXB2 and 6-keto-PGF1alpha in plasma and in lung were detected by the technique of radioimmunology.
  
  
  RESULTS
  (1) mPAP was significantly higher in B group than those of A and C group. Differences of mCAP were not significant in three groups. (2) Light microscopy showed that WA/TA (vessel wall area/total area) and PAMT (the thickness of medial smooth cell layer) were significantly higher in B group than those of A and C group. (3) The concentration of TXB2 and 6-keto-PGF1alpha in plasma and lung as well as the ratio of TXB2/6-keto-PGF1alpha were significantly higher in rats of B group than those of A and C group.
  
  
  CONCLUSIONS
  Aspirin may inhibit hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling.
authors.affiliation: Department of Respirology, Institute of Cor Pulmonale, First Hospital, Wenzhou Medical College, Wenzhou 325003, China.
authors.forename: Hai-Huan
authors.initials: HH
authors.lastname: Zeng
authors.forename: Liang-Xing
authors.initials: LX
authors.lastname: Wang
authors.forename: Shao-Xian
authors.initials: SX
authors.lastname: Chen
authors.forename: Ming-Shan
authors.initials: MS
authors.lastname: Wang
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Fan
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology; D011464:Epoprostenol / Q000378:metabolism; D006935:Hypercapnia / Q000503:physiopathology*; D006976:Hypertension, Pulmonary / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D011651:Pulmonary Artery / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013928:Thromboxane A2 / Q000378:metabolism
chemical_list: D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D001241:Aspirin