title: CuI/I2-promoted electrophilic tandem cyclization of 2-ethynylbenzaldehydes with ortho-benzenediamines: synthesis of iodoisoquinoline-fused benzimidazoles.
abstract: An efficient tandem route to the synthesis of iodoisoquinoline-fused benzimidazole derivatives including an iodocyclization strategy has been developed. In the presence of CuI, a variety of 2-ethynylbenzaldehydes underwent the tandem reaction with benzenediamines and iodine to afford the corresponding iodoisoquinoline-fused benzimidazoles in moderate to good yields.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
authors.forename: Huang-Che
authors.initials: HC
authors.lastname: Ouyang
authors.forename: Ri-Yuan
authors.initials: RY
authors.lastname: Tang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhong
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: Zhang
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D001547:Benzaldehydes; D001562:Benzimidazoles; D007546:Isoquinolines; C413250:ethynylbenzaldehyde; D007455:Iodine