title: The characterization of a novel V1b antagonist lead series.
abstract: The SAR around a V1b antagonist HTS hit 3 was explored to produce a series of thiazole sulfonamides as a lead series with selectivity over the related V1 and oxytocin receptors.
authors.affiliation: GlaxoSmithKline Research and Development, New Frontiers Science Park, Harlow, UK.
authors.forename: Chris A
authors.initials: CA
authors.lastname: Smethurst
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Borthwick
authors.forename: Simon
authors.initials: S
authors.lastname: Gaines
authors.forename: Steve
authors.initials: S
authors.lastname: Watson
authors.forename: Andrew
authors.initials: A
authors.lastname: Green
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Schulz
authors.forename: George
authors.initials: G
authors.lastname: Burton
authors.forename: Alberto A
authors.initials: AA
authors.lastname: Buson
authors.forename: Roberto
authors.initials: R
authors.lastname: Arban
mesh_terms: D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D057166:High-Throughput Screening Assays; D051381:Rats; D018045:Receptors, Oxytocin / Q000037:antagonists & inhibitors / Q000378:metabolism; D017483:Receptors, Vasopressin / Q000378:metabolism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; D013449:Sulfonamides; D013844:Thiazoles