title: [Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats].
abstract: OBJECTIVE
  To observe the change of STR neuronal firing rates with high frequency stimulation of subthalamic nucleus in PD rats.
  
  
  METHODS
  A model of Parkinson's disease was induced by unilateral administration of 6-hydroxydopamine into right substantia nigra in rats. After the high-frequency stimulation to STN, the spontaneous firing rates of STR on normal and PD rats were recorded by using extracellular recordings.
  
  
  RESULTS
  Stimulation caused a direct excited effect of STR neurons in normal rats whereas a excited and inhibited effect in PD rats. The inhibited effect was correlated with the stimulation period (r = 0.94).
  
  
  CONCLUSIONS
  Stimulation to STN may inhibit the spontaneous firing rates of STR neurons in PD rats. These results also give some clues that high-frequency stimulation to STN may be a effective therapy to the clinical treatment of Parkinson's disease.
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110015, China.
authors.forename: Pei-Fei
authors.initials: PF
authors.lastname: Gu
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Gao
authors.forename: Yu
authors.initials: Y
authors.lastname: Shang
mesh_terms: D000200:Action Potentials; D000818:Animals; D003342:Corpus Striatum / Q000503:physiopathology*; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy; D008297:Male; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020531:Subthalamic Nucleus