title: Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma.
abstract: Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows MYC rearrangements with non-IGH genes in the setting of a complex karyotype possibly involving BCL2 and, less frequently, BCL6 rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with MYC, BCL2, and BCL6 rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.
authors.affiliation: Hematology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. krysmotllo@hotmail.com
authors.forename: Cristina
authors.initials: C
authors.lastname: Motlló
authors.forename: Javier
authors.initials: J
authors.lastname: Grau
authors.forename: Jordi
authors.initials: J
authors.lastname: Juncà
authors.forename: Neus
authors.initials: N
authors.lastname: Ruiz
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Mate
authors.forename: Elisa
authors.initials: E
authors.lastname: Orna
authors.forename: José-Tomás
authors.initials: JT
authors.lastname: Navarro
authors.forename: Susana
authors.initials: S
authors.lastname: Vives
authors.forename: Juan-Manuel
authors.initials: JM
authors.lastname: Sancho
authors.forename: Daniel
authors.initials: D
authors.lastname: Esteban
authors.forename: Isabel
authors.initials: I
authors.lastname: Granada
authors.forename: Evarist
authors.initials: E
authors.lastname: Feliu
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Ribera
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Millá
mesh_terms: D000328:Adult; D000368:Aged; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D003582:Cytogenetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D051560:Proto-Oncogene Proteins c-bcl-6; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051560:Proto-Oncogene Proteins c-bcl-6; D016271:Proto-Oncogene Proteins c-myc