title: Spontaneously regulated vs. controlled ventilation of acute lung injury/acute respiratory distress syndrome.
abstract: OBJECTIVE
  To present an updated discussion of those aspects of controlled positive pressure breathing and retained spontaneous regulation of breathing that impact the management of patients whose tissue oxygenation is compromised by acute lung injury.
  
  
  RESULTS
  The recent introduction of ventilation techniques geared toward integrating natural breathing rhythms into even the earliest phase of acute respiratory distress syndrome support (e.g., airway pressure release, proportional assist ventilation, and neurally adjusted ventilatory assist), has stimulated a burst of new investigations.
  
  
  CONCLUSIONS
  Optimizing gas exchange, avoiding lung injury, and preserving respiratory muscle strength and endurance are vital therapeutic objectives for managing acute lung injury. Accordingly, comparing the physiology and consequences of breathing patterns that preserve and eliminate breathing effort has been a theme of persisting investigative interest throughout the several decades over which it has been possible to sustain cardiopulmonary life support outside the operating theater.
authors.affiliation: University of Minnesota, St. Paul, Minnesota, USA. john.j.marini@healthpartners.com
authors.forename: John J
authors.initials: JJ
authors.lastname: Marini
mesh_terms: D055371:Acute Lung Injury / Q000503:physiopathology*; D006801:Humans; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology*; D012119:Respiration; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*