title: Novel bis-indole agents active against multidrug-resistant Acinetobacter baumannii.
abstract: The in vitro activity of 5 novel Microbiotix bis-indole agents (MBXs) (Microbiotix, Worcester, MA) against 30 multidrug-resistant (MDR) Acinetobacter baumannii (including 18 resistant to carbapenems) was evaluated. Overall, MIC(90)'s ranged from 1 to 8 μg/mL, whereas those for imipenem were >64 μg/mL. MBX 1196 was the most potent (MIC(90), 1 μg/mL). MBXs are compounds that are highly effective against MDR A. baumannii.
authors.affiliation: Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH 44106, USA. mrj6@cwru.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: Saralee
authors.initials: S
authors.lastname: Bajaksouzian
authors.forename: Caryn E
authors.initials: CE
authors.lastname: Good
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Butler
authors.forename: John D
authors.initials: JD
authors.lastname: Williams
authors.forename: Norton P
authors.initials: NP
authors.lastname: Peet
authors.forename: Terry L
authors.initials: TL
authors.lastname: Bowlin
authors.forename: Andrea
authors.initials: A
authors.lastname: Endimiani
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles