title: Efficient singlet oxygen generation by luminescent 2-(2′-thienyl)pyridyl cyclometalated platinum(II) complexes and their calixarene derivatives.
abstract: Luminescent cyclometalated platinum(II) complexes, namely [Pt(Thpy)(PPh3)X]n+ (HThpy = 2-(2′-thienyl)pyridine; X = Cl− (1), n = 0; X = CH3CN (2), pyridine (3), n = 1) and [Pt(Thpy)(HThpy)Y]n+ (Y = Cl− (4), n = 0; Y = pyridine (5), n = 1), exhibit structured emission with peak maximum at ∼556 and 598 nm in degassed acetonitrile and with emission quantum yield and lifetime of up to 0.38 and 26 μs, respectively. These complexes are efficient photosensitizers of singlet oxygen with yields up to >90%. Complex 5 exhibited photocytotoxicity towards cancer cells and fluorescence microscopic images of cells incubated with 5 reveal substantial uptake at the nucleus and mitochondria.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Hong Kong SAR, China. swlai@hku.hk
authors.forename: Siu-Wai
authors.initials: SW
authors.lastname: Lai
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Lok
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
authors.forename: Matthias
authors.initials: M
authors.lastname: Selke
mesh_terms: D000818:Animals; D047250:Calixarenes / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D004247:DNA / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D066298:In Vitro Techniques; D049449:Luminescence; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology*; D055668:Photochemical Processes; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000187:drug effects; D026082:Singlet Oxygen / Q000737:chemistry*; D013053:Spectrophotometry
chemical_list: D009944:Organoplatinum Compounds; D017319:Photosensitizing Agents; D047250:Calixarenes; D026082:Singlet Oxygen; D012710:Serum Albumin, Bovine; D004247:DNA