title: Approaching MALDI molecular imaging for clinical proteomic research: current state and fields of application.
abstract: MALDI imaging mass spectrometry ('MALDI imaging') is an increasingly recognized technique for biomarker research. After years of method development in the scientific community, the technique is now increasingly applied in clinical research. In this article, we discuss the use of MALDI imaging in clinical proteomics and put it in context with classical proteomics techniques. We also highlight a number of upcoming challenges for personalized medicine, development of targeted therapies and diagnostic molecular pathology where MALDI imaging could help.
authors.affiliation: Institute of Pathology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rauser
authors.forename: Sören-Oliver
authors.initials: SO
authors.lastname: Deininger
authors.forename: Detlev
authors.initials: D
authors.lastname: Suckau
authors.forename: Heinz
authors.initials: H
authors.lastname: Höfler
authors.forename: Axel
authors.initials: A
authors.lastname: Walch
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D006801:Humans; D008279:Magnetic Resonance Imaging; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D040081:Protein Array Analysis; D040901:Proteomics / Q000379:methods* / Q000639:trends; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends