title: Migraine in women with chronic pelvic pain with and without endometriosis.
abstract: OBJECTIVE
  To examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis.
  
  
  METHODS
  Prospective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endometriosis was diagnosed pathologically. Headaches were classified as migraine or non-migraine using International Headache Society criteria.
  
  
  METHODS
  Clinical research hospital.
  
  
  METHODS
  108 women in a clinical trial for chronic pelvic pain (NCT00001848).
  
  
  METHODS
  Laparoscopy to diagnose endometriosis, assessment by neurologist to assess headaches.
  
  
  METHODS
  Prevalence of migraine and other headaches in women with chronic pelvic pain with or without endometriosis. Headache frequency, severity and relationship to pelvic pain and endometriosis.
  
  
  RESULTS
  Lifetime prevalence of definite or possible migraine was 67% of women with chronic pelvic pain. An additional 8% met criteria for possible migraine. Migraine was no more likely in women with endometriosis than those without. Women with the most severe headaches had a lower quality of life compared with those with pelvic pain alone.
  
  
  CONCLUSIONS
  Migraine headache is common in women with chronic pelvic pain, regardless of endometriosis, and contributes to disability in those with both conditions. The strong association suggests a common pathophysiology.
authors.affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1109, USA.
authors.forename: Barbara Illowsky
authors.initials: BI
authors.lastname: Karp
authors.forename: Ninet
authors.initials: N
authors.lastname: Sinaii
authors.forename: Lynnette K
authors.initials: LK
authors.lastname: Nieman
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Silberstein
authors.forename: Pamela
authors.initials: P
authors.lastname: Stratton
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004715:Endometriosis / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology*; D017699:Pelvic Pain / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery; D010919:Placebos; D015995:Prevalence; D011446:Prospective Studies; D011788:Quality of Life; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D004965:Estrogen Antagonists; D010919:Placebos; D020849:Raloxifene Hydrochloride