title: MAO inhibitors: risks, benefits, and lore.
abstract: Monoamine oxidase (MAO) inhibitors were the first antidepressants introduced, but their use has dwindled because of their reported side effects, their food and drug interactions, and the introduction of other classes of agents. However, interest in MAO inhibitors is reviving. Here, we discuss their use, risks, and benefits in clinical medicine.
authors.affiliation: Department of Psychiatry and Psychology, P57, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. wimbism@ccf.org
authors.forename: Molly
authors.initials: M
authors.lastname: Wimbiscus
authors.forename: Olga
authors.initials: O
authors.lastname: Kostenko
authors.forename: Donald
authors.initials: D
authors.lastname: Malone
mesh_terms: D000279:Administration, Cutaneous; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002611:Cheese; D003865:Major Depressive Disorder / Q000188:drug therapy; D005247:Feeding Behavior; D018565:Food-Drug Interactions; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000517:prevention & control; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D009206:Myocardium; D012307:Risk Factors; D012642:Selegiline / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014439:Tyramine
chemical_list: D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D014439:Tyramine