title: Pharmacological correction of testosterone deficiency during experimental myocardial ischemia.
abstract: Experiments on rats with myocardial ischemia modeled by occlusion of the left coronary artery aggravated by alimentary dislipoproteinemia showed that therapy with taurepar (50 mg/kg), a taurine derivative, decreased blood corticosterone concentration and increased the level of endogenous testosterone, which attests to normalization of the compensatory-adaptive and gonadotropic functions of the organism.
authors.affiliation: Department of Neuropharmacology, Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia. sns@iem.spb.ru
authors.forename: L K
authors.initials: LK
authors.lastname: Khnychenko
authors.forename: I V
authors.initials: IV
authors.lastname: Okunevich
authors.forename: Yu O
authors.initials: YO
authors.lastname: Fedotova
authors.forename: N S
authors.initials: NS
authors.lastname: Sapronov
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D050171:Dyslipidemias / Q000188:drug therapy; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000503:physiopathology*; D051381:Rats; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013739:Testosterone / Q000097:blood / Q000172:deficiency*
chemical_list: D004041:Dietary Fats; C518136:taurepar; D013654:Taurine; D013739:Testosterone; D003345:Corticosterone