title: [Inulicin inhibits activation and expression of vascular remodeling enzymes induced by de-endothelium].
abstract: OBJECTIVE
  To observe the effects of inulicin on the neointimal hyperplasia and expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) after balloon injury in rat aorta.
  
  
  METHODS
  The intimal hyperplasia model was replicated by balloon injury. The histological changes in vascular wall were observed by HE staining. MMP-2 activation was tested by gelatin zymogram analysis; MMP-2 and TIMP-2 expression was detected by Western blot and immunohistochemistry analysis.
  
  
  RESULTS
  Neointimal hyperplasia induced by balloon injury was significantly inhibited by inulicin. The proteolytic activity and the expression of MMP-2 and ratio of MMP-2 and TIMP-2 were also returned to control level by inulicin after balloon injury.
  
  
  CONCLUSIONS
  Inulicin inhibits hyperplasia of neointima by modulating the balance of MMP-2 and TIMP-2.
authors.affiliation: Hebei Laboratory of Medical Biotechnology, Institute of Basic Medicine, Heibei Medical University, Shijiazhuang 050017, China.
authors.forename: Juan-Juan
authors.initials: JJ
authors.lastname: Li
authors.forename: Jin-Kun
authors.initials: JK
authors.lastname: Wen
authors.forename: Mei
authors.initials: M
authors.lastname: Han
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D006965:Hyperplasia / Q000517:prevention & control; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D058426:Neointima / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D012717:Sesquiterpenes / Q000494:pharmacology*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; D019716:Tissue Inhibitor of Metalloproteinase-2; C031971:inulicin; D020778:Matrix Metalloproteinase 2; C522363:Mmp2 protein, rat