title: New antibody to stop tumor angiogenesis and lymphatic spread by blocking receptor partnering.
abstract: Tvorogov et al. (2010) describe in this issue of Cancer Cell an antibody that inhibits homodimerization of vascular endothelial growth factor receptor-3 (VEGFR-3) and its heterodimerization with VEGFR-2, but not ligand binding. The work provides mechanistic insights into receptor dimerization and an approach to suppress both angiogenesis and lymphangiogenesis.
authors.affiliation: UCSF Comprehensive Cancer Center, Cardiovascular Research Institute, Department of Anatomy, University of California, San Francisco, CA 94143, USA. donald.mcdonald@ucsf.edu
authors.forename: Donald M
authors.initials: DM
authors.lastname: McDonald