title: Complication of adenoid cystic carcinoma and sialolithiasis in the submandibular gland: report of a case and its etiological background.
abstract: The authors report a case of adenoid cystic carcinoma (ACC) complicated with sialolithiasis of the submandibular gland. The patient was a 43-year-old female with a history of papillotubular carcinoma of the breast almost at the same time. She had noticed a swelling in her sublingual area for 10 years, which was later diagnosed by her dentist to be due to a sialolith in the left submandibular gland. After several years of observation, the patient was referred to have her left submandibular gland, containing the stone, surgically removed with a diagnosis of atrophic sialadenitis. Histopathologically, the submandibular gland was extensively replaced with fibrous granulation tissue, in which there were small but invasive foci of ACC. The present case indicates that ACC could arise in the background of chronic sialadenitis. It is suggested that long-standing sialadenitis cases should be carefully examined to exclude suspicion of malignancy before surgery.
authors.affiliation: Division of Oral Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: J
authors.initials: J
authors.lastname: Cheng
authors.forename: S
authors.initials: S
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: A
authors.initials: A
authors.lastname: Iida
authors.forename: R
authors.initials: R
authors.lastname: Takagi
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: C
authors.initials: C
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Saku
mesh_terms: D000328:Adult; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D018987:Salivary Ducts / Q000473:pathology; D015494:Salivary Gland Calculi / Q000175:diagnosis*; D012793:Sialadenitis / Q000175:diagnosis*; D013364:Submandibular Gland Diseases / Q000175:diagnosis*; D013365:Submandibular Gland Neoplasms / Q000175:diagnosis*