title: The role of cobalt-albumin binding analysis in the diagnosis of experimental abdominal compartment syndrome in rabbits.
abstract: BACKGROUND
  The purpose of our study was to examine the role of cobalt-albumin binding assay (CABA) for the early diagnosis of abdominal compartment syndrome (ACS).
  
  
  METHODS
  Twenty-four anesthetized and ventilated rabbits were randomly assigned to four groups as 1 to 4, with each group comprised of six animals. Intraabdominal hypertension of 25 mmHg was induced for 15, 30, 45, and 60 minutes by insufflation in the four groups, respectively. Five ml of blood was drawn from each animal before the animals were sacrificed. A CABA test was performed on the samples and results were compared with pathologic diagnosis of intestinal samples shown as a score of damage severity values.
  
  
  RESULTS
  Ischemia-modified albumin (IMA) in Group 4 was significantly higher than in Group 1 and Group 2 (0.65 ± 0.16, 0.60 ± 0.25 and 0.61 ± 0.14, respectively; p < 0.05). However, there was no significant difference between the IMA of Group 3 and Group 4. Score of damage severity values reached statistically significant levels in Group 4 compared with Group 1 and Group 2 (p < 0.004 and 0.006, respectively) and in Group 3 compared with Group 1 (p < 0.004). There was also a statistically significant difference between Groups 1 and 2 (p < 0.004).
  
  
  CONCLUSIONS
  CABA plays an important role in the early diagnosis of ACS at the beginning of intestinal ischemia.
authors.affiliation: Department of Emergency Medicine, İzmir Atatürk Research and Training Hospital, İzmir, Turkey. erdenun@yahoo.com
authors.forename: Erol Erden
authors.initials: EE
authors.lastname: Unlüer
authors.forename: Turgay Yilmaz
authors.initials: TY
authors.lastname: Kiliç
authors.forename: Evren
authors.initials: E
authors.lastname: Akgöl
authors.forename: Duygu
authors.initials: D
authors.lastname: Işgüven
authors.forename: Enver
authors.initials: E
authors.lastname: Vardar
authors.forename: Umit
authors.initials: U
authors.lastname: Bayol
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Nazif
authors.initials: N
authors.lastname: Erkan
authors.forename: Necati
authors.initials: N
authors.lastname: Gökmen
mesh_terms: D000005:Abdomen / Q000473:pathology / Q000503:physiopathology*; D000007:Abdominal Injuries / Q000175:diagnosis / Q000473:pathology; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D003161:Compartment Syndromes / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000209:etiology; D007327:Insufflation; D007511:Ischemia / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism; D013990:Tidal Volume / Q000502:physiology
chemical_list: D012709:Serum Albumin; D010100:Oxygen