title: The Brazilian database on pregnancy in multiple sclerosis.
abstract: OBJECTIVE
  To report the results from the Brazilian database on multiple sclerosis (MS) and pregnancy.
  
  
  METHODS
  Retrospective data from MS patients who became pregnant at any time of their disease were sent to a Brazilian database, using a specific file for this purpose.
  
  
  RESULTS
  Data on 128 women (142 pregnancies) from 30 neurologists working in 21 cities in Brazil were collected. Patients' average age at pregnancy was 29.8 years (range 16-42). EDSS at start of pregnancy was 1.5±1.4; and the relapse rate in the year preceding pregnancy was 1.2±1.5. Exposure to medication at any time during pregnancy was high (69.7%): 48.6% to interferon beta; 14.1% to glatiramer acetate; and 7% to other immunomodulatory and immunosuppressive drugs. There was a significant decrease in relapse rate during pregnancy. The prevalence of complications was relatively low, with 4.9% of obstetric and 1.4% neonatal unfavorable outcomes.
  
  
  CONCLUSIONS
  Our patients had low degrees of disability, short histories of disease, high drug exposure, and relatively high relapse rate in the year previous to pregnancy. Obstetric and neonatal outcomes were successful in over 90% of our patients.
authors.affiliation: HC de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Finkelsztejn
authors.forename: Y D
authors.initials: YD
authors.lastname: Fragoso
authors.forename: M L B
authors.initials: ML
authors.lastname: Ferreira
authors.forename: M A
authors.initials: MA
authors.lastname: Lana-Peixoto
authors.forename: S V
authors.initials: SV
authors.lastname: Alves-Leon
authors.forename: S
authors.initials: S
authors.lastname: Gomes
authors.forename: B P
authors.initials: BP
authors.lastname: Damasceno
authors.forename: M F
authors.initials: MF
authors.lastname: Mendes
authors.forename: P R
authors.initials: PR
authors.lastname: Salgado
authors.forename: E C
authors.initials: EC
authors.lastname: Correa
authors.forename: E R
authors.initials: ER
authors.lastname: Comini-Frota
authors.forename: D S
authors.initials: DS
authors.lastname: Diniz
authors.forename: P D
authors.initials: PD
authors.lastname: Gama
authors.forename: D R
authors.initials: DR
authors.lastname: Kaimen-Maciel
authors.forename: R R
authors.initials: RR
authors.lastname: Morales
authors.forename: W O
authors.initials: WO
authors.lastname: Arruda
authors.forename: A K
authors.initials: AK
authors.lastname: Grzesiuk
authors.forename: J M N
authors.initials: JM
authors.lastname: Khouri
authors.forename: J S
authors.initials: JS
authors.lastname: Lopes
authors.forename: C F
authors.initials: CF
authors.lastname: Rocha
authors.forename: R
authors.initials: R
authors.lastname: Domingues
authors.forename: M V M
authors.initials: MV
authors.lastname: Gonçalves
authors.forename: M A
authors.initials: MA
authors.lastname: Lorenti
authors.forename: M K F
authors.initials: MK
authors.lastname: Parolin
authors.forename: F
authors.initials: F
authors.lastname: Siquineli
authors.forename: E D
authors.initials: ED
authors.lastname: Tosta
authors.forename: J B B
authors.initials: JB
authors.lastname: Brooks
authors.forename: A S
authors.initials: AS
authors.lastname: Gallina
authors.forename: L D M
authors.initials: LD
authors.lastname: Melges
authors.forename: H H
authors.initials: HH
authors.lastname: Ruocco
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight / Q000187:drug effects; D001938:Brazil / Q000453:epidemiology; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D005260:Female; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D007370:Interferon Type I / Q000009:adverse effects / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000453:epidemiology*; D010455:Peptides / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011994:Recombinant Proteins; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D007370:Interferon Type I; D010455:Peptides; D011994:Recombinant Proteins; D000068717:Glatiramer Acetate