title: Specific detection of D-glucose by a tetraphenylethene-based fluorescent sensor.
abstract: A conceptually new "light-up" biosensor with a high specificity for d-glucose (Glu) in aqueous media has been developed. The emission from a tetraphenylethene (TPE)-cored diboronic acid (1) was greatly boosted when the fluorogen was oligomerized with Glu because of restriction of the intramolecular rotations of the aryl rotors of TPE by formation of the oligomer. Little change in the light emission was observed when 1 was mixed with D-fructose, D-galactose, or D-mannose, as these saccharides are unable to oligomerize with the fluorogen.
authors.affiliation: Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, MoE Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Chunmei
authors.initials: C
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Tang
authors.forename: Anjun
authors.initials: A
authors.lastname: Qin
authors.forename: Rongrong
authors.initials: R
authors.lastname: Hu
authors.forename: Jing Zhi
authors.initials: JZ
authors.lastname: Sun
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D005030:Ethylenes / Q000737:chemistry*; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008027:Light; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D001555:Benzene Derivatives; D001897:Boronic Acids; D005030:Ethylenes; D005947:Glucose