title: [Anti-tumoral matrikines: potential interest in oncology].
abstract: The word 'matrikine' designates certain peptides derived from partial degradation of extracellular matrix macromolecules and capable of modulating cellular activities. Some matrikines have been shown to inhibit tumor progression and/or neo-angiogenesis, suggesting they may have therapeutic potential. This review examines the main matrikines with anti-tumoral properties, and particularly those originating from basement membrane macromolecules. After a brief description of their discovery and main characteristics, we discuss their mode of production, mechanism of anti-tumor action, and therapeutic potential.
authors.affiliation: Laboratoire de Biochimie et Biologie Moléculaire, CNRS UMR 6237, Université de Reims Champagne-Ardenne, CHU de Reims, 51 rue Cognac Jay - 51095 Reims cedex. fmaquart@chu-reims.fr
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Maquart
mesh_terms: D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology*; D009389:Neovascularization, Pathologic; D010455:Peptides / Q000378:metabolism*
chemical_list: D010455:Peptides; D020782:Matrix Metalloproteinases