title: Evidence of human hantavirus infection and zoonotic investigation of hantavirus prevalence in rodents in western Java, Indonesia.
abstract: During febrile surveillance in the western Java City of Bandung, Indonesia, a patient with clinical symptoms consistent with hantavirus infection was found to have elevated titers of hantavirus-specific immunoglobulin M (IgM) and IgG antibodies. A subsequent epizoological investigation demonstrated a higher prevalence of hantavirus IgG antibodies in rodents trapped in the vicinity of the patient's home compared with rodents from a control area (13.2% vs. 4.7%, p = 0.036). The Old World Seoul hantavirus was detected by reverse transcriptase-polymerase chain reaction in the organs of 71% of the seropositive rodents tested. This is the first report of a Seoul virus infection in Indonesia supported by clinical, serological, and epizoological evidences. These findings suggest that hantavirus infection should be on the clinical differential diagnosis when acutely ill febrile patients report for care in western Java.
authors.affiliation: U.S. Naval Medical Research Unit 2, Jakarta, Indonesia.
authors.forename: Herman
authors.initials: H
authors.lastname: Kosasih
authors.forename: Ima Nurisa
authors.initials: IN
authors.lastname: Ibrahim
authors.forename: Rudi
authors.initials: R
authors.lastname: Wicaksana
authors.forename: Bachti
authors.initials: B
authors.lastname: Alisjahbana
authors.forename: Yumilia
authors.initials: Y
authors.lastname: Hoo
authors.forename: Iing H
authors.initials: IH
authors.lastname: Yo
authors.forename: Ungke
authors.initials: U
authors.lastname: Antonjaya
authors.forename: Susana
authors.initials: S
authors.lastname: Widjaja
authors.forename: Imelda
authors.initials: I
authors.lastname: Winoto
authors.forename: Maya
authors.initials: M
authors.lastname: Williams
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Blair
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D018778:Hantavirus Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D012377:Rodentia / Q000821:virology*; D015047:Zoonoses / Q000453:epidemiology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M