title: Potential of immunotherapy for hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. Since HCC has been shown to be immunogenic, T cell-based immunotherapy is considered a promising treatment. In this review, we summarize current knowledge of T cell responses against tumour-associated antigens, as well as the mechanisms underlying the poor quality of these responses in patients with HCC. Insights into these important aspects of HCC immunology are crucial for the further development of novel immunotherapies.
authors.affiliation: Department of Medicine II, University of Freiburg, Hugstetter Strasse 55, D-79106 Freiburg, Germany.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Breous
authors.forename: Robert
authors.initials: R
authors.lastname: Thimme
mesh_terms: D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000378:metabolism; D019496:Cancer Vaccines / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D008113:Liver Neoplasms / Q000276:immunology / Q000628:therapy*; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines