title: Utility of ProGRP determinations in cancer patients.
abstract: BACKGROUND
  The aim of this study was to assess the utility of ProGRP determinations in patients with selected cancer localization, during and after therapy.
  
  
  METHODS
  The study involved a reference group and a population of lung, breast, ovarian, and prostate cancer patients. ProGRP was evaluated using two-step chemiluminescent microparticle immunoassay (CMIA) manufactured by Abbott Diagnostics, and Architect i2000 analyzer.
  
  
  RESULTS
  During follow-up of SCLC patients, an increased value for ProGRP was found in 51% and for NSE only in 25.5% of the patients, whereas in NSCLC patients, percentages with elevated ProGRP and CYFRA 21-1 were 8.6% and 55.7%, respectively. SCLC patients also had the highest AUC values for ProGRP. In other cancers, the frequency of elevated ProGRP results were as follows: 13.1%--in breast cancer patients, 19.6%--in ovarian cancer patients, and 15.1%--in prostate cancer patients.
  
  
  CONCLUSIONS
  The presented study revealed that ProGRP is a tumor marker of choice in SCLC, because of its high diagnostic specificity in relation to the reference group and to the group with other malignancies.
authors.affiliation: Department of Clinical Biochemistry, Center of Oncology, M. Sklodowska-Curie Memorial Institute, Cracow Division, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wojcik
authors.forename: Urszula
authors.initials: U
authors.lastname: Rychlik
authors.forename: Piotr
authors.initials: P
authors.lastname: Skotnicki
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jakubowicz
authors.forename: Jan Kanty
authors.initials: JK
authors.lastname: Kulpa
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D007118:Immunoassay; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood; D012372:ROC Curve; D011994:Recombinant Proteins / Q000097:blood; D012016:Reference Values
chemical_list: D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D011994:Recombinant Proteins; C087079:pro-gastrin-releasing peptide (31-98); D010751:Phosphopyruvate Hydratase