title: Three-dimensional models of the oligomeric human asialoglycoprotein receptor (ASGP-R).
abstract: The work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor (ASGP-R), by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown. An articulated step-wise modeling protocol was used in order to build the receptor model in a minimal oligomeric form, necessary for it to bind multi-antennary carbohydrate ligands. The ultimate target of the study is to contribute to increasing the knowledge of interactions between the human ASGP-R and carbohydrate ligands, at the molecular level, pertinent to applications in the field of hepatic tissue engineering.
authors.affiliation: UdR INSTM, Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy; E-Mail: ilaria@dcci.unipi.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Massarelli
authors.forename: Federica
authors.initials: F
authors.lastname: Chiellini
authors.forename: Emo
authors.initials: E
authors.lastname: Chiellini
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Bianucci
mesh_terms: D000595:Amino Acid Sequence; D037263:Asialoglycoprotein Receptor / Q000737:chemistry*; D001665:Binding Sites; D006801:Humans; D062105:Molecular Docking Simulation; D008969:Molecular Sequence Data; D011485:Protein Binding; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary
chemical_list: D037263:Asialoglycoprotein Receptor