title: [Progress in metabolic mechanism of docosahexenoic acid production by fermentation].
abstract: Docosahexenoic acid (DHA) is an important polyunsaturated fatty acid which is beneficial to human health. Compared with the DHA derived from fish oil, DHA by microbial production possesses many advantages, and has a bright prospect. In this article, we reviewed strains, metabolic pathway, key enzymes and mechanism of lipid accumulation for microbial production of DHA. Those information would be greatly helpful for further improving DHA production by metabolic engineering.
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Feng
authors.forename: Lujing
authors.initials: L
authors.lastname: Ren
authors.forename: Ping
authors.initials: P
authors.lastname: Wei
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Tong
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ji
authors.forename: He
authors.initials: H
authors.lastname: Huang
mesh_terms: D004281:Docosahexaenoic Acids / Q000096:biosynthesis*; D056890:Eukaryota / Q000378:metabolism*; D005285:Fermentation; D007218:Industrial Microbiology / Q000379:methods*; D060847:Metabolic Engineering / Q000379:methods*
chemical_list: D004281:Docosahexaenoic Acids