title: Nasopharyngeal T-cell monomorphic posttransplant lymphoproliferative disorders and combined IgA nephropathy and membranous glomerulonephritis in a patient with renal transplantation: a case report with literature review.
abstract: Recurrent and/or de novo glomerular diseases occurring in a renal allograft have been reported in the literature and are an important cause of graft dysfunction and eventual loss. The simultaneous occurrence of two glomerulonephritis, although reported in the literature, is a rare phenomenon. Posttransplant lymphoproliferative disorders (PTLD) are well known and one of the most serious and potentially fatal complications of chronic immunosuppression in the solid organ transplant recipient. Here, we are reporting the first case, to the best of our knowledge, of simultaneous occurrence of nasopharyngeal monomorphic monoclonal PTLD and two distinctive glomerular diseases (IgA nephropathy and membranous glomerulonephritis) in a 49-year-old patient who was 5 years post-renal transplantation. We have provided the clinical history of our patient who presented with nephrotic range proteinuria, microscopic hematuria, and a nasopharyngeal mass as well as a review of the literature.
authors.affiliation: Department of Histopathology, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia. halakfoury@hotmail.com
authors.forename: H K
authors.initials: HK
authors.lastname: Kfoury
authors.forename: M
authors.initials: M
authors.lastname: Alghonaim
authors.forename: A K
authors.initials: AK
authors.lastname: AlSuwaida
authors.forename: S Naseem
authors.initials: SN
authors.lastname: Zaidi
authors.forename: M
authors.initials: M
authors.lastname: Arafah
mesh_terms: D005922:Glomerulonephritis, IGA / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation; D008232:Lymphoproliferative Disorders / Q000473:pathology*; D009305:Nasopharynx / Q000473:pathology*; D013601:T-Lymphocytes / Q000166:cytology*