title: Beta-fibrinogen G-455A polymorphisms and recurrent miscarriage.
abstract: OBJECTIVE
  The aim of this study was to investigate whether differences could be detected in genotype and allele frequencies of β-fibrinogen G-455A in relation to recurrent miscarriage (RM).
  
  
  METHODS
  β-Fibrinogen G-455A polymorphism was investigated by sequencing analysis in 98 women with RM and 78 control women who had no history of miscarriage (controls).
  
  
  RESULTS
  The frequency of the -455 A/A genotype of β-fibrinogen was significantly different in women with RM compared with control women. The A/A genotype was found in 8 women of Group 1 (8.2%), but was not detected in any woman of the control group. In contrast, no differences were found in the allele frequencies between RM and control women.
  
  
  CONCLUSIONS
  Women with the A/A genotype could have an increased risk of RM. However, the allele frequencies were similar between women with recurrent pregnancy loss and control women, suggesting that the effect of β-fibrinogen polymorphisms on RM, if any, is actually very slight.
authors.affiliation: Department of Surgery, Section of Gynecology and Obstetrics, Tor Vergata University, Rome, Italy. ticconi@med.uniroma2.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Ticconi
authors.forename: Francesca
authors.initials: F
authors.lastname: Mancinelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Gravina
authors.forename: Giorgio
authors.initials: G
authors.lastname: Federici
authors.forename: Emilio
authors.initials: E
authors.lastname: Piccione
authors.forename: Sergio
authors.initials: S
authors.lastname: Bernardini
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics; D055815:Young Adult
chemical_list: D005340:Fibrinogen