title: Is there a role of p53 codon 72 polymorphism in the susceptibility to type 2 diabetes in overweight subjects? A study in patients with cardiovascular diseases.
abstract: Two hundred and eighty six subjects with cardiovascular diseases and 147 healthy newborns were studied. P53 codon 72 polymorphism was determined by DNA analysis. The association between BMI and diabetes depends on p53 polymorphism: Odds Ratio shows a high significant association between BMI and diabetes in *Arg/*Arg subjects (p=0.00001). No significant association is observed in *Pro allele carriers (p=0.203).
authors.affiliation: Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy. gloria@med.uniroma2.it
authors.forename: F
authors.initials: F
authors.lastname: Gloria-Bottini
authors.forename: M
authors.initials: M
authors.lastname: Banci
authors.forename: P
authors.initials: P
authors.lastname: Saccucci
authors.forename: A
authors.initials: A
authors.lastname: Magrini
authors.forename: E
authors.initials: E
authors.lastname: Bottini
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications / Q000235:genetics*; D003062:Codon; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D003062:Codon