title: [Immunological alterations and selectin values in hypertensive patients treated according to current criteria].
abstract: OBJECTIVE
  To calculate the relationship of E and P selectins with immunological changes in essential hypertension.
  
  
  METHODS
  We included 261 patients with essential hypertension with or without left ventricular hypertrophy (LVH), in whom selectins and specific cytokines were quantified.
  
  
  RESULTS
  E-and P-selectins were increased in hypertension compared to controls [75(51) ng/mL versus 45(17) ng/mL, (p<0.0001) and 47(18) ng/mL versus 38(15) ng/mL, (p=0.049), respectively], as well as cytokine concentrations (p<0.0001). Furthermore, selectin values were significantly correlated with changes in immunological markers. The multivariate analysis showed that IL-1ra (p<0.0001) and P-selectin (p=0.013) were independent factors of E-selectin values. For P-selectin, IL-1ra (p=0.005), IL-8 (p<0.0001) and selectin-E (p=0.013) influenced on its concentration. Finally, selectin values were similar between patients with or without left ventricular hypertrophy.
  
  
  CONCLUSIONS
  Immunological activation influenced on selectin concentrations in cardiologic asymptomatic patients with essential hypertension. LVH did not induce significant changes.
authors.affiliation: Unidad de Cardiocirculación, Centro de Investigación, Hospital Universitario La Fe, Valencia, España.
authors.forename: Raquel
authors.initials: R
authors.lastname: Cortés
authors.forename: Manuel
authors.initials: M
authors.lastname: Portolés
authors.forename: Esther
authors.initials: E
authors.lastname: Roselló-Lletí
authors.forename: José Ramón
authors.initials: JR
authors.lastname: González-Juanatey
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu
authors.forename: Miguel
authors.initials: M
authors.lastname: Rivera
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D058070:Asymptomatic Diseases; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D048909:Diabetes Complications / Q000453:epidemiology; D050171:Dyslipidemias / Q000453:epidemiology; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000209:etiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D012907:Smoking / Q000453:epidemiology
chemical_list: D000959:Antihypertensive Agents; D016207:Cytokines; D019040:E-Selectin; D019007:P-Selectin