title: 20-HETE in acute kidney injury.
abstract: Ischemia/reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) that is associated with a patient mortality of up to 50%. Currently there are not effective pharmacologic therapies for AKI. This Commentary highlights recent evidence indicating that 20-HETE plays an important role in IRI and that drugs that target this pathway have potential as therapeutic agents for AKI.
authors.affiliation: Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA. rroman@umc.edu
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Roman
authors.forename: Talha
authors.initials: T
authors.lastname: Akbulut
authors.forename: Frank
authors.initials: F
authors.lastname: Park
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Regner
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000037:antagonists & inhibitors* / Q000378:metabolism* / Q000627:therapeutic use; D051381:Rats; D015427:Reperfusion Injury / Q000150:complications*
chemical_list: C494667:20-hydroxyeicosa-6(Z),15(Z)-dienoic acid; D006893:Hydroxyeicosatetraenoic Acids; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid