title: One allele's loss is another's gain: alterations of NKX2-8 in non-small cell lung cancer.
abstract: Large-scale genetic changes such as loss or gain of chromosomes are important drivers of solid tumor carcinogenesis. Recent technological advances in genomic profiling have allowed quantitative detection of gene copy numbers, leading to identification of the 14q13.3 gene locus as functionally important in non-small cell lung cancers.
authors.affiliation: Stanford Cancer Center, Stanford, California, USA.
authors.forename: Joel W
authors.initials: JW
authors.lastname: Neal
authors.forename: Alice T
authors.initials: AT
authors.lastname: Shaw
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics*; D058990:Molecular Targeted Therapy; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; C108070:NKX2-8 protein, human; D014157:Transcription Factors