title: [Relationship between lung injury induced by hemorrhagic shock/reperfusion and nitric oxide and beneficial effect of taurine].
abstract: OBJECTIVE
  To approach the relationship between lung injury induced by shock/reperfusion and nitric oxide as well as the beneficial effect of taurine.
  
  
  METHODS
  Twenty four rabbits were divided randomly into 3 groups (n = 8): control group, shock group, taurine group. The model of lung injury induced by shock/reperfusion was used. The activities of nitric oxide synthase (NOS), superoxide dismutase (SOD), the contents of malondialdehyde (MDA), nitric oxide products (NO2-/NO3-) in plasma and lung homogenate, lung wet/dry weight, lung water content, lung permeability index, and protein content in the pulmonary alveolar lavage fluid were measured. Meanwhile, pathologic samples treated routinely.
  
  
  RESULTS
  (1) At 3 hours after reperfusion, the activities of SOD in plasma and lung homogenate decreased markedly, but the other indexes above mentioned were increased significantly compared with the control group (P < 0.01). (2) A close correlation was shown between MDA content and NO2-/NO3- content in plasma and lung. Furthermore, the content of NO2-/NQ3- in lung homogenate showed strong positive correlation with the lung injury parameters. (3) Taurine (40 mg x kg(-1) i.v.) could attenuate all the changes above mentioned at the same time points of reperfusion.
  
  
  CONCLUSIONS
  NO may play an important role in lung injury induced by shock/reperfusion. Taurine can ameliorate the lung injury, mechanism of which may be related to decreasing the generation of NO and anti-lipoperoxidation.
authors.affiliation: Department of Pathophysiology, Medical College of Shihezi University, Shihezi 832002, China.
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Sun
authors.forename: Feng-Mei
authors.initials: FM
authors.lastname: Deng
authors.forename: Hua
authors.initials: H
authors.lastname: Zhong
authors.forename: Cheng-Jing
authors.initials: CJ
authors.lastname: Chu
mesh_terms: D000818:Animals; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D055370:Lung Injury / Q000209:etiology / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011817:Rabbits; D015427:Reperfusion Injury / Q000150:complications / Q000188:drug therapy; D012771:Shock, Hemorrhagic / Q000150:complications / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D013654:Taurine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase