title: The relationship of insulin secretion and GAD65 antibody levels at diagnosis on glycemic control in type 2 diabetes.
abstract: OBJECTIVE
  To determine if pretreatment insulin and C-peptide levels together with antibody status are predictive of HbAlc levels before and during therapy in obese African-American youth with type 2 diabetes.
  
  
  METHODS
  Records of African-American patients with clinical diagnosis of type 2 diabetes were retrospectively analyzed. Insulin, C-peptide, blood glucose, HbA1c and islet autoantibodies at diagnosis were recorded. These variables were compared with HbA1c levels during therapy.
  
  
  RESULTS
  Eight of 45 patients were islet autoantibody positive. There was no difference in age, Body Mass Index z-score, insulin, C-peptide, glucose or HbAlc levels between antibody positive or negative patients. Insulin (r = -0.45, p < 0.01 n=45) and C-peptide (r = -0.59, p < 0.001, n=36) were correlated with HbA1c at diagnosis but not during therapy.
  
  
  CONCLUSIONS
  Higher insulin levels were associated with lower HbA1c at presentation but not during therapy. Antibody status was not associated with differences in insulin, C-peptide levels or HbAlc level.
authors.affiliation: Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Louisiana State University Health Sciences Center-School of Medicine and Children's Hospital, New Orleans, LA, USA.
authors.forename: Pinar
authors.initials: P
authors.lastname: Gumus
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gomez
authors.forename: Alfonso
authors.initials: A
authors.lastname: Vargas
authors.forename: Stuart
authors.initials: S
authors.lastname: Chalew
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D015992:Body Mass Index; D002096:C-Peptide / Q000032:analysis; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000628:therapy; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D002096:C-Peptide; D005968:Glutamate Decarboxylase; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human; C401141:glutamate decarboxylase 2