title: [Autologous fat grafting in radiated tissue prior to breast prosthetic reconstruction: is the technique reliable?].
abstract: BACKGROUND
  Prosthetic breast reconstruction is critical in the radiated breast. The main purpose of this study was to determine whether fat grafting prior to breast reconstruction could improve thoracic tissue trophicity enough to perform a simple prosthetic reconstruction, avoiding a flap procedure.
  
  
  METHODS
  A total of 25 patients who had undergone a modified radical mastectomy followed by radiotherapy were retrieved. Fat was injected according to Coleman's technique. Prosthetic reconstruction was performed three to six months after the fat grafting procedure. Reconstruction of the nipple-areola complex was performed 3 months after implant positioning. Median follow-up interval was two years. Patient satisfaction was ascertained with a self-assessment questionnaire. Three independent blinded physician observers judged preoperative and postoperative photographs to determine the quality of reconstruction.
  
  
  RESULTS
  The mean refined fat injected volume was 160ml. In all cases except two, a unique fat grafting procedure was necessary. Prosthetic reconstruction was achieved in 23 cases. The technique failed in two cases and breast reconstruction was achieved by a latissimus dorsi flap with implant. During the follow-up interval, two complications occurred in two patients presenting with fat necrosis and oil cysts. The mean number of total surgical procedures was 2.5 per patient. Quality of reconstruction was judged as good by both physicians and patients.
  
  
  CONCLUSIONS
  Autologous fat grafting in radiated tissue prior to breast reconstruction is a safe and reliable technique. In selected cases, a simple prosthetic reconstruction can be achieved avoiding a flap procedure.
authors.affiliation: Service de chirurgie plastique et reconstructrice, hôpital Nord, chemin des Bourrely, 13915 Marseille cedex 20, France. yves.irani@gmail.com
authors.forename: Y
authors.initials: Y
authors.lastname: Irani
authors.forename: D
authors.initials: D
authors.lastname: Casanova
authors.forename: E
authors.initials: E
authors.lastname: Amar
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D000368:Aged; D001940:Breast / Q000528:radiation effects*; D018427:Breast Implants; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D015411:Mastectomy, Modified Radical / Q000009:adverse effects*; D008875:Middle Aged; D017060:Patient Satisfaction; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D015203:Reproducibility of Results; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014182:Transplantation, Autologous; D016896:Treatment Outcome