title: Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults.
abstract: Beneficial effects on body weight of supplementation with BCAA, including leucine, isoleucine, and valine, have been observed in animal and human studies. However, population-based studies on dietary BCAA intake and body weight are lacking. The objective of this study was to examine the association between dietary BCAA intake and risk of overweight status/obesity among multi-ethnic populations. The International Study of Macro-/Micronutrients and Blood Pressure is a cross-sectional epidemiological investigation in China, Japan, the UK, and the US. The study cohort included 4429 men and women ages 40-59 y who were free of diabetes. Diet was assessed by 4 multi-pass 24-h recalls; data on nutrients including BCAA were derived from country-specific food tables. Overweight status and obesity were defined as BMI ≥ 25 and BMI ≥ 30 kg/m(2), respectively. Multivariable-adjusted OR of overweight status/obesity and 95% CI by quartiles of BCAA intake were estimated by logistic regression. Mean BCAA intake was 2.6 ± 0.6% energy; intake was significantly lower among Chinese participants and similar among participants from the other 3 countries. Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of overweight status from the 2nd to 4th quartiles of BCAA intake were 0.97 (0.80-1.17), 0.91 (0.75-1.11), and 0.70 (0.57-0.86), respectively (P-trend < 0.01). BCAA intake and obesity were also inversely associated (P-trend = 0.03). In conclusion, higher dietary BCAA intake is associated with lower prevalence of overweight status/obesity among apparently healthy middle-aged adults from East Asian and Western countries.
authors.affiliation: Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Qin
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Xun
authors.forename: Deborah
authors.initials: D
authors.lastname: Bujnowski
authors.forename: Martha L
authors.initials: ML
authors.lastname: Daviglus
authors.forename: Linda
authors.initials: L
authors.lastname: Van Horn
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Stamler
authors.forename: Ka
authors.initials: K
authors.lastname: He
mesh_terms: D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000627:therapeutic use*; D002681:China / Q000453:epidemiology; D004032:Diet; D015930:Diet Records; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000517:prevention & control*; D016017:Odds Ratio; D050177:Overweight / Q000453:epidemiology / Q000517:prevention & control*; D015995:Prevalence; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D000597:Amino Acids, Branched-Chain