title: Improvement of urodynamic indices by single dose oral tadalafil in men with supra sacral spinal cord injury.
abstract: OBJECTIVE
  To investigate the changes in urodynamic indices following a single dose of oral tadalafil in patients with supra sacral spinal cord injury (SCI).
  
  
  METHODS
  Urodynamic study was accomplished on 20 patients with supra sacral SCI before and one hour after administration of 20 mg oral tadalafil as a single dose. Changes in the bladder capacity and compliance, maximum voiding detrusor pressure, and maximum detrusor filling pressure before and after tadalafil administration were recorded.
  
  
  RESULTS
  Following administration of 20 mg oral tadalafil, there was a significant increase in the bladder compliance (from 12.7 to 18.5 mL/cmH₂O, P < .001), bladder capacity (from 169.8 to 198.5 mL, P < .001), maximum voiding detrusor pressure (from 64.8 to 48.6 cmH₂O, P < .001), and maximum detrusor filling pressure (from 24.3 to 14.0 cmH₂O, P < .001).
  
  
  CONCLUSIONS
  Single dose of oral tadalafil has significant positive effects on urodynamic indices in patients with supra sacral SCI.
authors.affiliation: Department of Urology, Imam Khomeini Grand Hospital, Jondishapour University of Medical Sciences, Ahvaz, Iran.
authors.forename: Karim
authors.initials: K
authors.lastname: Taie
authors.forename: Hayat
authors.initials: H
authors.lastname: Moombeini
authors.forename: Dinyar
authors.initials: D
authors.lastname: Khazaeli
authors.forename: Mohammad
authors.initials: M
authors.lastname: Salari Panah Firouzabadi
mesh_terms: D002243:Carbolines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D010865:Pilot Projects; D013119:Spinal Cord Injuries / Q000150:complications*; D000068581:Tadalafil; D001743:Urinary Bladder / Q000187:drug effects* / Q000503:physiopathology; D014555:Urination Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects*
chemical_list: D002243:Carbolines; D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil