title: Atypical dermatofibroma with predominant epithelioid/deciduoid-like cell component. Histogenetic considerations in the wide spectrum of fibrohistiocytic dermal tumours.
abstract: Atypical and epithelioid cell variants of dermatofibroma may represent a potential diagnostic pitfall. Only rarely atypical dermatofibroma may show focal epithelioid cell features. We herein report a rare case of dermatofibroma composed of a predominant (> 90%) epithelioid/deciduoid-like cell component, in which rare multinucleated bizarre cells and atypical mitoses were additional findings. Tumour was classified as "atypical dermatofibroma with predominant epithelioid/deciduoid-like cell component". The coexistence of at least two different variants, i.e. epithelioid and atypical variants, in the same dermatofibroma suggests that dermal fibrohistiocytic tumours belong to a continuous morphological spectrum. Accordingly, the morphological variants of dermatofibroma should be regarded as variations on a common basic theme. Differential diagnosis with other epitheliod cell dermal tumour- and tumour-like lesions is discussed.
authors.affiliation: Dipartimento G.F. Ingrassia, Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele, Anatomia Patologica, Università di Catania, Italy. paoloamico@interfree.it
authors.forename: P
authors.initials: P
authors.lastname: Amico
authors.forename: G M
authors.initials: GM
authors.lastname: Vecchio
authors.forename: M
authors.initials: M
authors.lastname: Bisceglia
authors.forename: E
authors.initials: E
authors.lastname: Vasquez
authors.forename: G
authors.initials: G
authors.lastname: Magro
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D051677:Histiocytoma, Malignant Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor