title: Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study.
abstract: A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD.
authors.affiliation: Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. daniel.weintraub@uphs.upenn.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Weintraub
authors.forename: Mandy
authors.initials: M
authors.lastname: Sohr
authors.forename: Marc N
authors.initials: MN
authors.lastname: Potenza
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Siderowf
authors.forename: Mark
authors.initials: M
authors.lastname: Stacy
authors.forename: Valerie
authors.initials: V
authors.lastname: Voon
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Whetteckey
authors.forename: Glen R
authors.initials: GR
authors.lastname: Wunderlich
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
mesh_terms: D000368:Aged; D000547:Amantadine / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000978:Antiparkinson Agents; D000547:Amantadine