title: [Long-term results of dual anti-collagen membrane in guided tissue regeneration].
abstract: OBJECTIVE
  To evaluate the long-term clinical effect of dual anti-collagen membranes in guided tissue regeneration (GTR).
  
  
  METHODS
  This randomized clinical trial included 26 teeth in 24 patients, presenting a total of 31 lesions consisting of intrabony defects and furcation defects. Twenty-six teeth were divided into two groups and treated by GTR with dual anti-collagen membranes and atelocollagen membranes, respectively. At baseline, 6 months, 1, 3 and 6 years, the following parameters were recorded: clinical attachment level, probing depth, gingival recession and the quantity of alveolar bone analyzed by computer assisted densitometry image analysis (CADIA).
  
  
  RESULTS
  At 1 year after GTR surgery, the gain of clinical attachment in dual anti-collagen membranes group was (3.93 ± 1.74) mm, compared with (2.25 ± 1.90) mm in atelocollagen group (P = 0.044). The increasing of the value of CADIA in dual anti-collagen membrane and atelocollagen group were (53.14 ± 21.35) and (32.96 ± 17.97), P = 0.031. At 3 and 6 years, clinical parameters remained basically stable in both groups, compared to that at 1 year after surgery.
  
  
  CONCLUSIONS
  The regeneration of periodontal tissues obtained by GTR with dual anti-collagen membranes could be maintained on a long-term basis.
authors.affiliation: Department of Periodontology, Wuhan University, Wuhan 430079, China.
authors.forename: Shu-huan
authors.initials: SH
authors.lastname: Shang
authors.forename: Cheng-zhang
authors.initials: CZ
authors.lastname: Li
authors.forename: Ming-wen
authors.initials: MW
authors.lastname: Fan
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D001861:Bone Regeneration; D003094:Collagen; D003720:Densitometry / Q000379:methods; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery*; D010512:Periodontal Index; D055815:Young Adult
chemical_list: D008567:Membranes, Artificial; C059821:atelocollagen; D003094:Collagen