title: Brain atrophy and cerebral small vessel disease: a prospective follow-up study.
abstract: OBJECTIVE
  cerebral small vessel disease (SVD) is the most common cause of vascular dementia. Interest in the use of surrogate markers is increasing. The aims of this study were to determine if brain volume was different between patients with SVD and control subjects, whether it correlated with cognition in SVD, and whether changes in brain volume could be detected during prospective follow-up.
  
  
  METHODS
  thirty-five patients (mean age, 68.8 years) who had a lacunar stroke and radiological evidence of confluent leukoaraiosis and 70 age- and gender-matched control subjects were recruited. Whole-brain T1-weighted imaging and neuropsychological testing were performed after 1 year on all patients and after 2 years for the control subjects. Fully automated software was used to determine brain volume and percentage brain volume change. An executive function score was derived.
  
  
  RESULTS
  there was a significant difference in brain volume between the patients with SVD and control subjects (mean ± SD [mL] 1529 ± 84 versus 1573 ± 69, P=0.019). In the patients with SVD, there was a significant association between brain volume and executive function (r=0.501, P<0.05). The mean ± SD yearly brain atrophy rate for patients with SVD and control subjects was significantly different (-0.914% ± 0.8% versus -0.498% ± 0.4%, respectively, P=0.017). No change in executive function score was detected over this period.
  
  
  CONCLUSIONS
  brain volume is reduced in SVD and a decline is detectable prospectively. The correlation with executive function at a cross-sectional level and the change in brain volume with time are both promising for the use of brain atrophy as a surrogate marker of SVD progression.
authors.affiliation: Clinical Neuroscience, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK. a.nitkunan@sgul.ac.uk
authors.forename: Arani
authors.initials: A
authors.lastname: Nitkunan
authors.forename: Silvia
authors.initials: S
authors.lastname: Lanfranconi
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Charlton
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Barrick
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Markus
mesh_terms: D000368:Aged; D001284:Atrophy; D015415:Biomarkers; D001921:Brain / Q000473:pathology*; D015140:Dementia, Vascular / Q000209:etiology / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D049292:Leukoaraiosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D020521:Stroke / Q000150:complications / Q000473:pathology*
chemical_list: D015415:Biomarkers