title: Effects of sidestream cigarette smoke exposure on baroreflex components in spontaneously hypertensive rats.
abstract: We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) normotensive rats. Rats were exposed to SSCS during three weeks, 180 min, five days per week, in a concentration of carbon monoxide (CO) between 100 and 300 ppm. We observed that SSCS exposure increased tachycardic peak and heart rate range while it attenuated bradycardic reflex in WKY. In respect to SHR, SSCS also increased tachycardic peak. Taken together, our data suggests that three weeks of exposure to SSCS affects the sympathetic and parasympathetic component of the baroreflex in normotensive WKY while it tended to affect the sympathetic component in SHR.
authors.affiliation: Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. valenti@unifesp.br
authors.forename: Vitor E
authors.initials: VE
authors.lastname: Valenti
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Abreu
authors.forename: Paulo H
authors.initials: PH
authors.lastname: Saldiva
authors.forename: Tatiana D
authors.initials: TD
authors.lastname: Carvalho
authors.forename: Celso
authors.initials: C
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D017704:Baroreflex; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D010275:Parasympathetic Nervous System / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012906:Smoke / Q000009:adverse effects*; D013045:Species Specificity; D013564:Sympathetic Nervous System / Q000187:drug effects; D013610:Tachycardia / Q000503:physiopathology*
chemical_list: D012906:Smoke