title: The potential economic value of a hookworm vaccine.
abstract: Hookworm infection is a significant problem worldwide. As development of hookworm vaccine proceeds, it is essential for vaccine developers and manufacturers, policy makers, and other public health officials to understand the potential costs and benefits of such a vaccine. We developed a decision analytic model to evaluate the cost-effectiveness of introducing a hookworm vaccine into two populations in Brazil: school-age children and non-pregnant women of reproductive age. Results suggest that a vaccine would provide not only cost savings, but potential health benefits to both populations. In fact, the most cost-effective intervention strategy may be to combine vaccine with current drug treatment strategies.
authors.affiliation: Public Health Computational and Operations Research, PA, USA. BYL1@pitt.edu
authors.forename: Bruce Y
authors.initials: BY
authors.lastname: Lee
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Bacon
authors.forename: Rachel
authors.initials: R
authors.lastname: Bailey
authors.forename: Ann E
authors.initials: AE
authors.lastname: Wiringa
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000723:Ancylostomatoidea / Q000276:immunology*; D000818:Animals; D001938:Brazil / Q000453:epidemiology; D002648:Child; D003362:Cost-Benefit Analysis; D005260:Female; D006725:Hookworm Infections / Q000191:economics / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D014612:Vaccines / Q000191:economics* / Q000276:immunology*
chemical_list: D014612:Vaccines