title: Unusual clinical presentations of new-onset herpetic eye disease after ocular surgery.
abstract: OBJECTIVE
  To report five cases of new-onset herpetic eye disease with unusual presentation after ocular surgery.
  
  
  METHODS
  Herpetic eye disease was suspected in five cases, three after cataract surgery and two after lamellar corneal transplantation surgery. Of these, four cases presented within 2-6 weeks of surgery. The clinical presentation was in the form of an epithelial defect, suspected epithelial down growth, graft oedema with unexplained anterior chamber inflammation and graft-host interface infection. A swab for viral detection with real-time polymerase chain reaction was performed in all the described cases.
  
  
  RESULTS
  Herpes simplex disease was detected in all cases. All cases responded to the antiherpetic medications.
  
  
  CONCLUSIONS
  Our study shows that new-onset herpetic eye disease may occur after cataract surgery and lamellar corneal transplantation, and a high index of suspicion may be necessary for the diagnosis in such cases.
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Vishal
authors.initials: V
authors.lastname: Jhanji
authors.forename: Mervyn
authors.initials: M
authors.lastname: Ferdinands
authors.forename: Harsha
authors.initials: H
authors.lastname: Sheorey
authors.forename: Namrata
authors.initials: N
authors.lastname: Sharma
authors.forename: Darren
authors.initials: D
authors.lastname: Jardine
authors.forename: Rasik B
authors.initials: RB
authors.lastname: Vajpayee
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D016039:Corneal Transplantation; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D018259:Herpesvirus 1, Human / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D016849:Keratitis, Herpetic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D016133:Polymerase Chain Reaction; D014775:Virus Activation; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D000212:Acyclovir