title: Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively.
abstract: Thirty-one dogs were randomised to receive intermittent wound infusion of bupivacaine or saline after surgery. Wound pressure sensitivity, pain scores, body temperature, heart rate, respiratory rate, analgesic drugs administered, time to walking and time to eating after surgery were recorded. Plasma bupivacaine concentrations were measured. The relative frequency distributions of the non-interventional and interventional pain scores, but not the relative frequency distributions of palpation pain scores or wound pressure sensitivity, were significantly different between groups following surgery. There was a significant difference between groups in the time to eating and in the amount and timing of analgesic drugs administered. Measured plasma bupivacaine concentrations demonstrated systemic absorption of the drug. Bupivacaine infusion into surgical wounds after surgery may improve post-operative recovery, but no effect on wound tenderness was demonstrated in this study.
authors.affiliation: College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 20606, USA. Electronic address: lizette_hardie@ncsu.edu.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Hardie
authors.affiliation: College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 20606, USA.
authors.forename: B Duncan X
authors.initials: BDX
authors.lastname: Lascelles
authors.affiliation: College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 20606, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: Meuten
authors.affiliation: College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 20606, USA.
authors.forename: Gigi S
authors.initials: GS
authors.lastname: Davidson
authors.affiliation: College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 20606, USA.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Papich
authors.affiliation: College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St., Raleigh, NC 20606, USA.
authors.forename: Bernie D
authors.initials: BD
authors.lastname: Hansen
mesh_terms: D000779:Anesthetics, Local / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D002045:Bupivacaine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004285:Dogs / Q000601:surgery*; D004311:Double-Blind Method; D036502:Infusions, Intralesional / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary*; D011182:Postoperative Care / Q000662:veterinary; D011446:Prospective Studies; D020127:Recovery of Function; D014945:Wound Healing
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine