title: Relationship between changes of bone mineral density over seven years and A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene or lifestyle factors in Japanese female workers.
abstract: A longitudinal study was conducted to investigate the relation between the changes of bone mineral density (BMD) over a seven-year period and A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) gene or lifestyle factors. The subjects were 113 premenopausal female employees from a large-scale integrated manufacturing facility in Japan aged 25.6 ± 4.2 years (mean ± standard deviation) at baseline. BMD was measured at the radius by dual energy X-ray absorptiometry. Lifestyle information was obtained by a questionnaire. The genotype frequencies of LRP5 gene polymorphism were 52%, 39%, and 9% for AA, AV, and VV, respectively. After seven years, BMD showed a significant decrease (from 0.463 ± 0.045 to 0.456 ± 0.046 g/m²) in subjects with the AV or VV genotypes, but not in subjects with the AA genotype. Analysis of covariance with adjustment for age and body mass index showed that subjects who drank alcohol displayed a significantly greater change of BMD if they had the AV or VV genotype than if they had the AA genotype (F=4.547, p=0.036). Investigation of LRP5 A1330V polymorphism may be useful for identifying individuals who are susceptible to osteoporosis, allowing early preventive measures to be provided.
authors.affiliation: Department of Public Health, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Funakoshi
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Omori
authors.forename: Hironori
authors.initials: H
authors.lastname: Yada
authors.forename: Takahiko
authors.initials: T
authors.lastname: Katoh
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics*; D004032:Diet / Q000379:methods / Q000706:statistics & numerical data; D015444:Exercise; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D026502:LDL-Receptor Related Proteins / Q000235:genetics*; D008019:Life Style; D008137:Longitudinal Studies; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D011110:Polymorphism, Genetic / Q000235:genetics*; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D005819:Genetic Markers; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5