title: HLA-DR alleles associated with skin warts induced by human  papillomavirus infection.
abstract: BACKGROUND
  The skin wart is a benign proliferation of the skin and mucous, secondary to human papillomavirus (HPV) infection.
  
  
  OBJECTIVE
  The objective of this study is to determine gene frequencies of HLA-DR alleles in Mexican patients with skin warts and compare them with those present in ethnically matched healthy subjects.
  
  
  METHODS
  Fifty-two patients with clinically and histologically confirmed skin warts from the Dermatology Outpatient Clinic, with results of high-resolution DNA typing for HLA-DR polymorphism.
  
  
  RESULTS
  HLA-DR3 and DR9 were increased (P = 0.0029, OR: 2.5, 95% CI: 1.3–4.7 and P = 0.0062, OR: 5.4, 95% CI: 1.4–19.5, respectively), and HLA-DR6 allele was found decreased (P = 0.0002).
  
  
  CONCLUSIONS
  The major histocompatibility complex contribution in the infection and elimination of the virus is not clear and perhaps also contributes to a series of events not well established yet.
  
  
  CONCLUSIONS
  This study follows the preponderant role of class II genes in the susceptibility or resistance to the development of skin warts caused by HPV infection.
authors.affiliation: Department of Dermatology, Hospital General Dr. Manuel Gea González, México City, Mexico. itzamma@hotmail.com
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Corona
authors.forename: Elisa
authors.initials: E
authors.lastname: Vega-Memije
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Barquera
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D015343:DNA Probes, HLA; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000235:genetics*; D011110:Polymorphism, Genetic; D014860:Warts / Q000235:genetics* / Q000821:virology; D055815:Young Adult
chemical_list: D015343:DNA Probes, HLA; D006684:HLA-DR Antigens