title: Spontaneous periodic hypothermia and hyperhidrosis: a possibly novel cerebral neurotransmitter disorder.
abstract: Spontaneous periodic episodes of hypothermia still defy medical knowledge. In 1969, Shapiro et al. described the first two cases of spontaneous periodic hypothermia associated with agenesis of the corpus callosum. Recently, Dundar et al. reported a case of spontaneous periodic hypothermia and hyperhidrosis without corpus callosum agenesis, suggesting that the periodic episodes of hypothermia might be of epileptiform origin. Here we describe two paediatric patients with spontaneous periodic hypothermia without corpus callosum agenesis and demonstrate, to our knowledge for the first time, altered levels of neurotransmitter metabolites within the cerebrospinal fluid.
authors.affiliation: Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo, Brazil. mmasruha@ig.com.br
authors.forename: Marcelo
authors.initials: M
authors.lastname: Rodrigues Masruha
authors.forename: Jaime
authors.initials: J
authors.lastname: Lin
authors.forename: Juliana Harumi
authors.initials: JH
authors.lastname: Arita
authors.forename: Eduardo Ferreira
authors.initials: EF
authors.lastname: De Castro Neto
authors.forename: Débora Amado
authors.initials: DA
authors.lastname: Scerni
authors.forename: Esper Abrão
authors.initials: EA
authors.lastname: Cavalheiro
authors.forename: Maria Da Graça Naffah
authors.initials: Mda G
authors.lastname: Mazzacoratti
authors.forename: Luiz Celso Pereira
authors.initials: LC
authors.lastname: Vilanova
mesh_terms: D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000150:complications*; D007035:Hypothermia / Q000150:complications*; D007223:Infant; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010507:Periodicity
chemical_list: D018377:Neurotransmitter Agents