title: Achiral bis-imine in combination with CoCl₂: A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol.
abstract: A bis-imine (prepared via a new FeCl₃-based method) in combination with CoCl₂ facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine.
authors.affiliation: Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India.
authors.forename: K
authors.initials: K
authors.lastname: Arunkumar
authors.forename: M Appi
authors.initials: MA
authors.lastname: Reddy
authors.forename: T Sravan
authors.initials: TS
authors.lastname: Kumar
authors.forename: B Vijaya
authors.initials: BV
authors.lastname: Kumar
authors.forename: K B
authors.initials: KB
authors.lastname: Chandrasekhar
authors.forename: P Rajender
authors.initials: PR
authors.lastname: Kumar
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal