title: Anemia at one year is an independent risk factor of graft survival.
abstract: BACKGROUND
  Post-transplant anemia is multifactorial and highly prevalent. Some studies have associated anemia with mortality and graft failure. The purpose of this study was to assess whether the presence of anemia at 1 year is an independent risk factor of mortality and graft survival.
  
  
  METHODS
  All patients transplanted at a single center who survived at least 1 year after transplantation and showed no graft loss (n = 214) were included. Demographic and clinical data were collected at baseline and at 1 year. Patients were divided into two groups (anemic and nonanemic) based on the presence of anemia (hemoglobin < 130 g/l in men and 120 g/l in women).
  
  
  RESULTS
  Baseline characteristics such as age, gender, type of donor, CKD etiology, rejection, and mismatches were similar in both groups. Creatinine clearance was similar in both anemic and nonanemic groups (69.32 ± 29.8 × 75.69 ± 30.5 ml/mim; P = 0.17). A Kaplan-Meier plot showed significantly poorer death-censored graft survival in the anemic group, P = 0.003. Multivariate analysis revealed that anemic patients had a hazard ratio for the graft loss of 3.85 (95% CI: 1.49-9.96; P = 0.005).
  
  
  CONCLUSIONS
  In this study, anemia at 1 year was independently associated with death-censored graft survival and anemic patients were 3.8-fold more likely to lose the graft.
authors.affiliation: Department of Internal Medicine, Botucatu Medical School, Botucatu, ZIP Code: 18.610-000, Brazil. landrade@fmb.unesp.br
authors.forename: Luís Gustavo Modelli
authors.initials: LG
authors.lastname: de Andrade
authors.forename: Juliana Maria Gera
authors.initials: JM
authors.lastname: Abrão
authors.forename: Maria Fernanda Cordeiro
authors.initials: MF
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D000740:Anemia / Q000097:blood* / Q000150:complications*; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D005260:Female; D006085:Graft Survival; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D051436:Renal Insufficiency, Chronic / Q000601:surgery; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D003404:Creatinine