title: Beyond the crystallization paradigm: structure determination from diffraction patterns from ensembles of randomly oriented particles.
abstract: We amplify on the principles of the method we have recently proposed for recovering an oversampled diffraction pattern of a single particle from measured diffraction patterns from multiple particles in orientations related by rotation about an axis parallel to the incident radiation. We propose an alternative method of phasing a reference resolution ring by means of a non-negativity constraint on the diffraction intensities, point out the need for caution about enantiomeric ambiguities in the reconstruction of a diffraction pattern from its angular correlations, and show that converged correlations may be deduced by appropriate averaging of even very noisy data.
authors.affiliation: Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Poon
authors.forename: D K
authors.initials: DK
authors.lastname: Saldin
mesh_terms: D000465:Algorithms; D003460:Crystallization / Q000379:methods*; D004583:Electrons; D007091:Image Processing, Computer-Assisted; D011829:Radiation Dosage; D014961:X-Ray Diffraction / Q000379:methods*