title: [Adrenal lesions in patients of multiple endocrine neoplasia type 1].
abstract: OBJECTIVE
  To investigate the prevalence and characteristics of adrenal lesions in Chinese multiple endocrine neoplasia type 1 (MEN-1) patients.
  
  
  METHODS
  Adrenal CT scan and clinical manifestations were retrospectively reviewed in 32 consecutive MEN-1 patients who were evaluated at our hospital during January 1986 to December 2009.
  
  
  RESULTS
  Adrenal lesions were identified in 16 of 32 (50%) MEN-1 patients. Five (31.3%) patents with adrenal involvement showed bilateral lesions, including bilateral adenoma (n=1), bilateral hyperplasia (n=2) and adenoma and hyperplasia on each side (n=2). Unilateral adrenal lesion was presented in 11 (68.7%) patients. Among which, 63.6% had adenomas with a mean diameter of 2.3 cm (0.8-4.0 cm) and the remainder was of hyperplasia or enlargement. In two patients, functioning adrenal abnormalities were detected including Cushing adenoma (n=1) and aldosterone-secreting adenoma (n=1).
  
  
  CONCLUSIONS
  The prevalence of adrenal lesion in MEN-1 patient is similar between China and western countries. These tumors are mostly benign, small and nonfunctioning. Taking into account a high incidence of adrenal carcinoma in previous foreign studies, routine screening and close surveillance are still recommended for adrenal lesions in MEN-1 patients.
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Hua-bing
authors.initials: HB
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Nai-shi
authors.initials: NS
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Fu
authors.forename: Ou
authors.initials: O
authors.lastname: Wang
authors.forename: Ling-ling
authors.initials: LL
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: An-li
authors.initials: AL
authors.lastname: Tong
authors.forename: Hui-juan
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Ming-ming
authors.initials: MM
authors.lastname: Hu
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
authors.forename: Jiang-feng
authors.initials: JF
authors.lastname: Mao
authors.forename: Tao
authors.initials: T
authors.lastname: Yuan
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Xia
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Xing
mesh_terms: D000311:Adrenal Glands / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult