title: Ethanol and vestibular stimulation reveal simple and complex aspects of cerebellar heterogeneity.
abstract: Unlike the cerebral cortex, the cerebellum is characterized by a simple histological organization that is relatively uniform throughout. However, molecular characteristics of its constituent elements create a high degree of heterogeneity and complexity resulting in the delineation of modules defined by both parasagittal and anteroposterior boundaries. Eccles notion of the cerebellum as "designed to process input information in some unique and essential manner" may relate to analysis of temporal elements involved in both motor and cognitive behaviors. The complexity of molecular heterogeneities may provide for subtle alterations in temporal processing and lead to behavioral perturbations seen after alcohol or other disruptive stimuli.
authors.affiliation: Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. Leonard.Eisenman@jefferson.edu
authors.forename: Leonard M
authors.initials: LM
authors.lastname: Eisenman
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002531:Cerebellum / Q000033:anatomy & histology / Q000187:drug effects*; D002772:Cholera Toxin / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D000431:Ethanol / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006360:Heat-Shock Proteins / Q000378:metabolism; D051379:Mice; D018832:Molecular Chaperones; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009434:Neural Pathways / Q000502:physiology*; D010852:Picrotoxin / Q000494:pharmacology; D043585:Receptor, Muscarinic M2 / Q000378:metabolism; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism; D014722:Vestibule, Labyrinth / Q000502:physiology*
chemical_list: D001285:Atropine; D002492:Central Nervous System Depressants; D002772:Cholera Toxin; D000431:Ethanol; D018756:GABA Antagonists; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D018727:Muscarinic Antagonists; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D010852:Picrotoxin; D043585:Receptor, Muscarinic M2; D018094:Receptors, Metabotropic Glutamate; C486113:Hsbp1 protein, mouse; C104077:metabotropic glutamate receptor type 1; C092565:zebrin I