title: Recent cerebrospinal fluid biomarker studies of Alzheimer's disease.
abstract: Alzheimer's disease is a progressive neurodegenerative disorder and the most common form of dementia. The disease is confirmed by the presence of neuritic plaques and neurofibrillary tangles in the cerebral cortex at autopsy, but the accuracy of antemortem diagnosis, especially at the early stages of the disease, is not ideal. Thus, there is a substantial need for the discovery and validation of diagnostic biomarkers. Many Alzheimer's disease biomarker discovery studies emphasize the analysis of cerebrospinal fluid (CSF) because of its close association with the brain. Here, we review recent mass spectrometry-based studies of Alzheimer's disease CSF, and additionally discuss issues associated with CSF in proteomics studies.
authors.affiliation: Department of Chemical Engineering and Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA.
authors.forename: Yong Seok
authors.initials: YS
authors.lastname: Choi
authors.forename: Leila H
authors.initials: LH
authors.lastname: Choe
authors.forename: Kelvin H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D000818:Animals; D015415:Biomarkers / Q000134:cerebrospinal fluid; D006801:Humans; D040901:Proteomics / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D053719:Tandem Mass Spectrometry; D057825:Two-Dimensional Difference Gel Electrophoresis
chemical_list: D015415:Biomarkers