title: Immunogenicity and safety of diphtheria-tetanus vaccine in adults.
abstract: This study was conducted to evaluate the immunogenicity and safety of diphtheria-tetanus (Td) vaccine in adults over 40 yr old who had never received a diphtheria-tetanus-pertussis (DTP) vaccination. A total of 242 subject completed three-doses of Td vaccination and subsequent assays for immunogenicity. Before vaccination, 33.9% and 96.7% participants showed antibody levels of diphtheria and tetanus, respectively, which were below protective level (<0.1 U/mL). After the first dose of Td vaccine, 92.6% and 77.6% of subjects gained protective antibody concentrations (≥ 0.1 U/mL) for diphtheria and tetanus, with an increase to 99.6% and 100% after the third dose. Local and systemic adverse events occurred in 37.9% and 15.5% of the subjects. No serious adverse event requiring an unscheduled hospital visit occurred. In conclusion, three-doses of Td vaccination to unimmunized adults are safe and effective in inducing protective immunity against diphtheria and tetanus.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Choi
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Choo
authors.forename: Aejung
authors.initials: A
authors.lastname: Huh
authors.forename: Su-Mi
authors.initials: SM
authors.lastname: Choi
authors.forename: Joong Sik
authors.initials: JS
authors.lastname: Eom
authors.forename: Jin Seo
authors.initials: JS
authors.lastname: Lee
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Park
authors.forename: Jin Han
authors.initials: JH
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D004165:Diphtheria / Q000517:prevention & control; D022422:Diphtheria-Tetanus Vaccine / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D013742:Tetanus / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022422:Diphtheria-Tetanus Vaccine; D013745:Tetanus Toxoid