title: SERS chiral recognition and quantification of enantiomers through cyclodextrin supramolecular complexation.
abstract: We introduce here a simple approach in which a cyclodextrin, functionalized with thiols in the narrower rim, is assembled onto the silver surface of a SERS platform composed of polystyrene beads coated with silver nanoparticles. Trapping properties of the fabricated sensor are demonstrated through the retention of different enantiomers (R,R or/and S,S) of hydrobenzoin (HBZ), a molecule that has not been reported before in SERS because it has no affinity for coinage metal surfaces. Further, selective recognition of each enantiomer and semiquantification of its proportion in a racemic mixture are provided by the analysis of the SERS spectra of the HBZ-cyclodextrin complex, in full agreement with the surface selection rules.
authors.affiliation: Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Abalde-Cela
authors.forename: José M
authors.initials: JM
authors.lastname: Hermida-Ramón
authors.forename: Pablo
authors.initials: P
authors.lastname: Contreras-Carballada
authors.forename: Luisa
authors.initials: L
authors.lastname: De Cola
authors.forename: Andrés
authors.initials: A
authors.lastname: Guerrero-Martínez
authors.forename: Ramón A
authors.initials: RA
authors.lastname: Alvarez-Puebla
authors.forename: Luis M
authors.initials: LM
authors.lastname: Liz-Marzán