title: [A study on the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia].
abstract: OBJECTIVE
  To investigate the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia.
  
  
  METHODS
  In the case-control study, the gene polymorphisms of glutathione S-transferases were tested in Tibetan mountaineers and sea-level Han Chinese by multiple-PCR and PCR-RELP.
  
  
  RESULTS
  The frequency of GSTT1 null genotype was significant different between Tibetan mountaineers and sea-level Han Chinese (P < 0.05), OR = 1.86 (95% CI = 1.01-3.39), and also for GSTP(1-105) mutant genotype in two groups (P < 0.01), OR = 2.19 (95% CI = 1.16-4.13). There was significant difference between A allele and G allele of GSTP(1-105) groups (P < 0.01). There was no difference for GSTM1 null genotype between two groups (P > 0.05), OR = 0.78 (95% CI = 0.43 - 1.42).
  
  
  CONCLUSIONS
  GSTT1 and GSTP(1-105) genotype may be associated with susceptibility response to altitude hypoxia.
authors.affiliation: Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine of Sichuan University, Chengdu 610041, China.
authors.forename: Hui-qin
authors.initials: HQ
authors.lastname: Yan
authors.forename: Xue-chuan
authors.initials: XC
authors.lastname: Sun
authors.forename: Kong-xiang
authors.initials: KX
authors.lastname: Liu
authors.forename: Sheng-wei
authors.initials: SW
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D002681:China; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D000860:Hypoxia / Q000235:genetics*; D008297:Male; D009051:Mountaineering; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species / Q000378:metabolism; D055815:Young Adult
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D017382:Reactive Oxygen Species; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human