title: Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia.
abstract: Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.
authors.affiliation: Department of Medical Oncology, Istanbul Bilim University School of Medicine, Istanbul, Turkey. keremokutur007@yahoo.com
authors.forename: Kerem
authors.initials: K
authors.lastname: Okutur
authors.forename: Baris
authors.initials: B
authors.lastname: Hasbal
authors.forename: Kubra
authors.initials: K
authors.lastname: Aydin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Bozkurt
authors.forename: Esat
authors.initials: E
authors.lastname: Namal
authors.forename: Buge
authors.initials: B
authors.lastname: Oz
authors.forename: Kamil
authors.initials: K
authors.lastname: Kaynak
authors.forename: Gokhan
authors.initials: G
authors.lastname: Demir
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D006177:Gynecomastia / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008198:Lymph Nodes / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human