title: Role of clusters in insulin-regulated GLUT4 trafficking in adipose cells: a new paradigm?
abstract: Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et al. found that insulin controls the spatial distribution of GLUT4 on the surface of isolated adipose cells through regulation of their post-fusion dispersal. The presence of GLUT4 in plasma membrane-associated clusters is suggestive of a new paradigm in membrane protein recycling.
authors.affiliation: EDMNS, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 , USA. jian.yang@nih.gov
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D021381:Protein Transport / Q000187:drug effects*
chemical_list: D051275:Glucose Transporter Type 4; D007328:Insulin