title: Primary sarcoma of the liver and transplantation: a case study and literature review.
abstract: Primary sarcomas of the liver are rare tumors and their diagnosis is difficult to assess, particularly on percutaneous liver biopsy. Epithelioid hemangioendothelioma (EHE) is an infrequent indication for liver transplantation, and angiosarcoma (AS) is a widely recognized contraindication because of its poor prognosis. We report the case of a young woman who underwent liver transplantation (LT) for an infiltrative hepatic tumor with several features suggestive of EHE, although the analysis of the native liver revealed AS. Everolimus was used as the main immunosuppressive drug. More than two years after LT, her physical condition remained stable despite a local recurrence at 10 months. In this setting, the ranking of new immunosuppressive agents belonging to the family of the proliferation signal inhibitors will need to be precise, but their intrinsic properties suggest a potential use in treatments after LT for atypical malignancies.
authors.affiliation: Service des Maladies de l'Appareil Digestif et de la Nutrition;
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bismuth
authors.forename: Hélène
authors.initials: H
authors.lastname: Castel
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Boleslawski
authors.forename: David
authors.initials: D
authors.lastname: Buob
authors.forename: Marc
authors.initials: M
authors.lastname: Lambert
authors.forename: Nicole
authors.initials: N
authors.lastname: Declerck
authors.forename: Valérie
authors.initials: V
authors.lastname: Canva
authors.forename: Eli-Serge
authors.initials: ES
authors.lastname: Zafrani
authors.forename: Philippe
authors.initials: P
authors.lastname: Mathurin
authors.forename: François-René
authors.initials: FR
authors.lastname: Pruvot
authors.forename: Sébastien
authors.initials: S
authors.lastname: Dharancy