title: Short- and long-term outcomes of living donors in Tunisia: a retrospective study.
abstract: Despite initiatives to increase cadaveric donation, there is still a shortfall in donor organs. Kidneys from living donors now makes a significant contribution to increasing the number of organs available for transplantation in Tunisia. We performed a retrospective study of 405 kidney transplantations, including 321 (79.3%) from living donors performed from June 1986 to December 2007. We obtained information on only 162 (50.4%), namely, 64 men (39.5%) and 98 women (60.5%), whose mean age at the time of donation was 42.3 ± 12.2 years. Twelve (8.22%) perioperative complications occurred: wound infections (n = 4), pneumothorax (n = 4), phlebitis (n = 1), hematomas (n = 2), and urinary infection (n = 1). The mean follow-up period was 117.4 ± 74.4 months. Hypertension occurred in 42 donors (25.9%) with mean values of 134 ± 20 for systolic and 79 ± 10 for diastolic blood pressure. Twelve donors (7.4%) developed proteinuria (mean proteinuria, 0.08 ± 1.25 g/d). Renal insufficiency was found in 28 donors (19.44%), 2 of whom developed chronic renal failure requiring dialysis at intervals of 36 and 84 months. In both cases, we diagnosed a familial form of focal segmental glomerulosclerosis. Two donors (1.2%) died within 10 years after kidney donation due to senility. The relatively favorable outcomes suggest that living-donor kidney transplantation is an acceptable approach, in view of the superior results it yields in recipients. However, efforts to increase the number of cadaveric donors in Tunisia should be made. It is also important to develop a registry of long-term kidney function after kidney donation.
authors.affiliation: Department of Internal Medicine A, Charles Nicolle Hospital, Tunis, Tunisia. mejdacherif@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Cherif
authors.forename: M
authors.initials: M
authors.lastname: Ounissi
authors.forename: C
authors.initials: C
authors.lastname: Karoui
authors.forename: K
authors.initials: K
authors.lastname: Boubaker
authors.forename: I
authors.initials: I
authors.lastname: Helal
authors.forename: F
authors.initials: F
authors.lastname: Ben Hamida
authors.forename: E
authors.initials: E
authors.lastname: Abderrahim
authors.forename: F
authors.initials: F
authors.lastname: El Younsi
authors.forename: A
authors.initials: A
authors.lastname: Kheder
authors.forename: A
authors.initials: A
authors.lastname: Derouich
authors.forename: M
authors.initials: M
authors.lastname: Sfaxi
authors.forename: R
authors.initials: R
authors.lastname: Ben Slama
authors.forename: M
authors.initials: M
authors.lastname: Chebil
authors.forename: R
authors.initials: R
authors.lastname: Bardi
authors.forename: I
authors.initials: I
authors.lastname: Sfar
authors.forename: T
authors.initials: T
authors.lastname: Ben Abdallah
authors.forename: Y
authors.initials: Y
authors.lastname: Gorgi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications; D012189:Retrospective Studies; D014416:Tunisia