title: [Effect of propofol on anti-oxidation capability in the ischemia/reperfusion injury after hepatic ischemia in rabbits].
abstract: OBJECTIVE
  To investigate the role of oxygen free radicals (OFR) in hepatic ischemia and reperfusion injury (HI/RI) and effect of propofol on them.
  
  
  METHODS
  The rabbits were randomly divided into three groups (n=10), sham operated group (Control), HIR group(I/R) and HIR + propofol group (PRO). Changes of several parameters which included malondialdehyde (MDA), superoxide dismutase (SOD), xanthine oxidase (XO) and alanine aminotransferase(ALT) were measured before ischemia, 45 minutes after ischemia and 45 minutes after reperfusion in plasma. Meanwhile MDA concentration, SOD, XO activities and ALT value in liver tissue were measured, and the ultrastructure changes in liver tissue were observed under electron microscope at 45 minutes after reperfusion.
  
  
  RESULTS
  As compared with group control, XO, MDA and ALT increased and SOD decreased during HI/RI (P < 0.05 and P < 0.01) in plasma, and XO, MDA increased as well as SOD decreased at 45 minutes after reperfusion (P < 0.05 and P < 0.01) in liver tissue and there were abnormal changes of the hepatic ultrastructure at 45 minutes after reperfusion. Propofol reversed the results of mentioned indices as above markedly (P < 0.05 and P < 0.01).
  
  
  CONCLUSIONS
  OFR is an important factor during HI/RI, propofol may attenuate hepatic ischemia-reperfusion injury by dropping OFR level (raising SOD activity and dropping XO activity) and antagonizing lipid pe-reoxidation (reducing MDA content).
authors.affiliation: Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325027, China.
authors.forename: Wan-tie
authors.initials: WT
authors.lastname: Wang
authors.forename: Li-na
authors.initials: LN
authors.lastname: Lin
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Li
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D016166:Free Radical Scavengers / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000648:ultrastructure; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D000410:Alanine Transaminase; D015742:Propofol