title: Laser systems for ablative fractional resurfacing.
abstract: Ablative fractional resurfacing (AFR) creates microscopic vertical ablated channels that are surrounded by a thin layer of coagulated tissue, constituting the microscopic treatment zones (MTZs). AFR induces epidermal and dermal remodeling, which raises new possibilities for the treatment of a variety of skin conditions, primarily chronically photodamaged skin, but also acne and burn scars. In addition, it is anticipated that AFR can be utilized in the laser-assisted delivery of topical drugs. Clinical efficacy coupled with minimal downtime has driven the development of various fractional ablative laser systems. Fractionated CO(2) (10,600-nm), erbium yttrium aluminum garnet, 2940-nm and yttrium scandium gallium garnet, 2790-nm lasers are available. In this article, we present an overview of AFR technology, devices and histopathology, and we summarize the current clinical possibilities with AFR incorporating our personal experience. AFR is still in the exploratory era, and systematic investigations of clinical outcomes related to various system settings are needed.
authors.affiliation: University of Leipzig, Department for Dermatology, Venerology and Allergology, Philipp-Rosenthal-Strasse 23, 04103 Leipzig, Germany. Uwe.Paasch@medizin.uni-leipzig.de
authors.forename: Uwe
authors.initials: U
authors.lastname: Paasch
authors.forename: Merete
authors.initials: M
authors.lastname: Haedersdal
mesh_terms: D003357:Cosmetic Techniques / Q000295:instrumentation*; D062109:Dermatologic Surgical Procedures; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation*; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing