title: [The correlation between the expression of EGFR in tumor tissue and in peripheral blood in non-small cell lung cancer patients].
abstract: OBJECTIVE
  it has been proven that EGFR plays an important role in cell proliferation, and has predictive values for diagnosis and prognosis. The aim of this study is to investigate the correlation between the expression of EGFR in tumor tissue and peripheral blood in non-small cell lung cancer (NSCLC) patients.
  
  
  METHODS
  the expression of EGFR was analyzed by real-time RT-PCR in 46 NSCLC tumor tissues and by ELISA in peripheral blood, compared with 10 patients with benign pulmonary diseases as control.
  
  
  RESULTS
  linear correlation analysis revealed there was a correlation of the expression of EGFR protein between peripheral blood and tumor tissue (P=0.016, R2=0.83).
  
  
  CONCLUSIONS
  the expression of EGFR mRNA in tumor tissue was positively correlated with EGFR protein in plasma. Detection of protein in plasma may replace that in tumor tissue, providing a quicker and easier examination method for the patients lacking biopsy tissue.
authors.affiliation: Department of Medical Oncology, Affiliated Hospital of Binzhou Medical College, Binzhou 256603, China.
authors.forename: Chen
authors.initials: C
authors.lastname: GUO
authors.forename: Qisen
authors.initials: Q
authors.lastname: GUO
authors.forename: Hongsheng
authors.initials: H
authors.lastname: ZENG
authors.forename: Yinling
authors.initials: Y
authors.lastname: ZHUO
authors.forename: Yan
authors.initials: Y
authors.lastname: GUAN
authors.forename: Xiuju
authors.initials: X
authors.lastname: LIU
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000235:genetics / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D066246:ErbB Receptors / Q000097:blood* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors