title: [The inhibition activity of chemical constituents in hawthorn fruit and their synergistic action to HMG-CoA reductase].
abstract: OBJECTIVE
  To study the hypolipidemic active compounds from Crataegus pinnatifida and mechanism of action of those.
  
  
  METHODS
  Guided by the inhibitory activity to HMG-CoA reductase, the active compounds were separated and purified with macroporous resin and silica gel.
  
  
  RESULTS
  Four active compounds were obtained, which were quercetin, hyperoside, rutin and chlorogenic acid, the sum of their inhibitory rate was 50.01%, and the total inhibitory rate of the mixture of four active compounds matched was 79.48%.
  
  
  CONCLUSIONS
  Quercetin and hyperoside were the principle active components inhibiting HMG-CoA reductase in Hawthorn fruit, and there were synergistic action among them.
authors.affiliation: Institute of Pharmaceutical Resources, School of Pharmaceutical Science, Southwest University, Chongqing 400716, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Huang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Ye
authors.forename: Xuegang
authors.initials: X
authors.lastname: Li
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Lan
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Jiaying
authors.initials: J
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Feng
mesh_terms: D027825:Crataegus / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006903:Hydroxymethylglutaryl CoA Reductases / Q000032:analysis; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010936:Plant Extracts; D006903:Hydroxymethylglutaryl CoA Reductases