title: [Inhibitory effect of soman on stress induced hyperthermia in rats and the influence of central and peripheral cholinergic antagonists].
abstract: OBJECTIVE
  To determine the effect of soman on stress induced hyperthermia and the influence of central and peripheral cholinergic antagonists.
  
  
  METHODS
  Effects of subcutaneous injection of soman, scopolamine, methylscopolamine and pyridostigmine on stress-induced hyperthermia were observed in rats by radio telemetry in an open-field environment. Plasma cholinesterase (ChE) activity was measured by a spectrophotometry.
  
  
  RESULTS
  (1) Core temperature of the control group increased by 0.96 degrees C when exposed to open-field, whereas core temperature only increased by 0.55 degrees C in soman treated animals. Scopolamine, a central cholinergic antagonist, nearly abolished inhibitory effects of soman on core temperature when exposed to open-field. Methylscopolamine, a peripheral cholinergic antagonist, coadministered with soman reduced significantly the hyperthermic response to open-field exposure compared with rats dosed with soman. (2) Pyridostigmine, a peripheral anti-ChE agent that caused a 52% decrease in plasma ChE activity led to a significant enhancement of the hyperthermic response to open-field exposure. Methyl scopolamine nearly abolished the effects of pyridostigmine on stress-induced hyperthermia response.
  
  
  CONCLUSIONS
  Inhibitory effect of soman on the open field hyperthermia suggested that soman treatment hampered the ability of the rat to develop a normal hyperthermic response when placed in the open-field environment. Its inhibitory effects were mediated primarily through a central muscarinic pathway. In addition, peripheral cholinergic nerve was involved in the control of stress hyperthermic response.
authors.affiliation: Department of Pathophysiology, Chengdu Medical College, Chengdu 610081, China. ylyang@cmc.edu.cn
authors.forename: Yong-Lu
authors.initials: YL
authors.lastname: Yang
authors.forename: Yun-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lai
authors.forename: Jin
authors.initials: J
authors.lastname: Hui
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Chen
mesh_terms: D000818:Animals; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D002802:Cholinesterases / Q000097:blood; D005260:Female; D005334:Fever / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012999:Soman / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D013312:Stress, Physiological
chemical_list: D018680:Cholinergic Antagonists; D012999:Soman; D002802:Cholinesterases