title: Evaluation of destructive and reparative processes in the liver in experimental chronic granulomatosis of mixed (silicotic and tuberculous) etiology.
abstract: Experimental silicosis and silicotuberculosis induced by intravenous injection of silicon dioxide particles are characterized by extensive degenerative and necrotic processes in the liver parenchyma. After 6 months, fibrosis of portal tracts in silicotuberculosis and silicosis was 2.8- and 1.4-fold more pronounced that in BCG granulomatosis and silicosis, respectively. Depression of cellular and intracellular regeneration processes in the liver parenchyma was also observed.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Skurupiy
authors.forename: A P
authors.initials: AP
authors.lastname: Nadeev
authors.forename: M A
authors.initials: MA
authors.lastname: Karpov
mesh_terms: D000818:Animals; D002908:Chronic Disease; D006099:Granuloma / Q000209:etiology*; D008099:Liver / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012829:Silicosis / Q000150:complications / Q000473:pathology*; D014376:Tuberculosis / Q000150:complications / Q000473:pathology*