title: AT2 receptor signaling and sympathetic regulation.
abstract: There is a growing consensus that the balance between Angiotensin Type 1 (AT1R) and Angiotensin Type 2 (AT2R) signaling in many tissues may determine the magnitude and, in some cases the direction, of the biological response. Sympatho-excitation in cardiovascular diseases is mediated by a variety of factors and is, in part, dependent on Angiotensin II signaling in the central nervous system. Recent data have provided evidence that the AT2R can modulate sympatho-excitation in animals with hypertension and heart failure. The evidence for this concept is reviewed and a model is put forward to support the rationale that therapeutic targeting of the central AT2R may be beneficial in the setting of chronic heart failure.
authors.affiliation: Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA.
authors.forename: Lie
authors.initials: L
authors.lastname: Gao
authors.forename: Irving H
authors.initials: IH
authors.lastname: Zucker
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000502:physiology; D044140:Receptor, Angiotensin, Type 1 / Q000032:analysis / Q000502:physiology; D044139:Receptor, Angiotensin, Type 2 / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2