title: [Anthropometric and metabolic evaluation of first-degree male relatives of women with polycystic ovary syndrome].
abstract: OBJECTIVE
  To evaluate clinical and laboratory characteristics of first-degree male relatives of patients with a confirmed diagnosis of polycystic ovary syndrome (PCOS) and to compare the findings with a control group with no family history of PCOS.
  
  
  METHODS
  We randomly selected 28 male individuals aged 18 to 65 years who were first-degree relatives of women diagnosed with PCOS and 28 controls matched for age, waist and body mass index (BMI).
  
  
  RESULTS
  Men with 1st degree kinship with women with PCOS had higher levels of triglycerides (189.6±103.1 versus 99.4±37.1, p<0.0001), Homeostasis Model Assessment (HOMA-IR) (3.5±9.1 versus 1.0±1.0, p=0.0077) and glucose (130.1±81.7 versus 89.5±7.8, p=0.005), and lower levels of sex hormone binding globulin (SHBG) (23.8±13.8 versus 31.1±9.1, p=0.003). SHBG levels correlated independently with triglyceride levels. These individuals also had more clinical signs of hyperandrogenism.
  
  
  CONCLUSIONS
  Male individuals who are first-degree relatives of patients with PCOS have a higher degree of dyslipidemia and insulin resistance, lower levels of SHBG, and more evident clinical signs of hyperandrogenism. These findings suggest that insulin resistance may be of hereditary origin in individuals with a family history of PCOS regardless of anthropometric parameters.
authors.affiliation: Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, RJ, Brasil. karinaschiavoni@yahoo.com.br
authors.forename: Karina Schiavoni Scandelai Cardoso dos
authors.initials: KS
authors.lastname: Reis
authors.forename: Rodrigo Oliveira
authors.initials: RO
authors.lastname: Moreira
authors.forename: Walmir Ferreira
authors.initials: WF
authors.lastname: Coutinho
authors.forename: Fernanda
authors.initials: F
authors.lastname: Vaisman
authors.forename: Carolina
authors.initials: C
authors.lastname: Gaya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000235:genetics; D055105:Waist Circumference / Q000235:genetics; D049629:Waist-Hip Ratio; D055815:Young Adult