title: [Expression of CD4+ CD25+ regulatory T cells and TGF-ß1 in patient with idiopathic thrombocytopenic purpura].
abstract: OBJECTIVE
  To investigate the expression rate of CD4+ CD25+ regulatory T cells and TGF-ß1 in peripheral blood of the patients with idiopathic thrombocytopenic purpura (ITP), and the role they play in the pathogenesis of ITP.
  
  
  METHODS
  The population of CD4+ CD25+ regulatory T cells in peripheral blood of 31 patients and 25 healthy donors was evaluated by flow cytometry, ELISA was used to test the level of TGF-ß1 in blood serum, and analysed the correlation between levels of CD4+ CD25+ regulatory T cells and TGF-ß1.
  
  
  RESULTS
  ITP patients had a lower proportion of CD4+ CD25+ regulatory T cells than the healthy donors (P<0.05). The level of TGF-ß1 in ITP patients was also lower than healthy donors (P<0.05). There was not positive correlation between levels of CD4+ CD25+ regulatory T cells and TGF-ß1 (P<0.05).
  
  
  CONCLUSIONS
  The results indicate that the decreasing of CD4+ CD25+ regulatory T cells in ITP patients may be connected with cellular immunity disturbance of idiopathic thrombocytopenic purpura. Further research need to be performed in metabolic changes on CD4+ CD25+ regulatory T cells and TGF-ß1 in patients with idiopathic thrombocytopenic purpura.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Xinjiang Medical University, China.
authors.forename: Ayimunisa
authors.initials: A
authors.lastname: Abudureheman
authors.forename: Halida
authors.initials: H
authors.lastname: Yasen
authors.forename: Zhao
authors.initials: Z
authors.lastname: Fang
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xue
authors.forename: Ding
authors.initials: D
authors.lastname: Jian-bing
authors.forename: Ma
authors.initials: M
authors.lastname: Xiu-min
authors.forename: Guo
authors.initials: G
authors.lastname: Xin-hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015704:CD4 Antigens / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000276:immunology / Q000473:pathology*; D015375:Receptors, Interleukin-2; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D053773:Transforming Growth Factor beta1 / Q000032:analysis / Q000097:blood*; D055815:Young Adult
chemical_list: D015704:CD4 Antigens; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit; D015375:Receptors, Interleukin-2; D053773:Transforming Growth Factor beta1