title: Compartmentalization of TNF-receptor 1 signaling: TNF-R1-associated caspase-8 mediates activation of acid sphingomyelinase in late endosomes.
authors.affiliation: Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Michaelisstr. 5, Kiel D-24105, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Bertsch
authors.forename: Bärbel
authors.initials: B
authors.lastname: Edelmann
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tchikov
authors.forename: Supandi
authors.initials: S
authors.lastname: Winoto-Morbach
authors.forename: Stefan
authors.initials: S
authors.lastname: Schütze
mesh_terms: D000818:Animals; D017209:Apoptosis; D053181:Caspase 8 / Q000378:metabolism*; D002402:Cathepsin D / Q000378:metabolism; D002451:Cell Compartmentation; D053418:Death Domain Receptor Signaling Adaptor Proteins / Q000378:metabolism; D004705:Endocytosis; D011992:Endosomes / Q000201:enzymology*; D004789:Enzyme Activation; D006801:Humans; D051379:Mice; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism*; D015398:Signal Transduction; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*
chemical_list: D053418:Death Domain Receptor Signaling Adaptor Proteins; D047888:Receptors, Tumor Necrosis Factor, Type I; D013108:Sphingomyelin Phosphodiesterase; D053181:Caspase 8; D002402:Cathepsin D