title: [The protective effects of ginkgolide B and hypoxic preconditioning against acute hypoxia injury in mice].
abstract: OBJECTIVE
  To investigate the protective effects of ginkgolide B and hypoxic preconditioning against acute hypoxia injury in mice.
  
  
  METHODS
  Ordinary pressure acute hypoxia model in mice was adopted to observe the ethology, the duration of the death and the degree of brain edema. Meanwhile the expression of RTP801 mRNA and erythropoietin (EPO) were measured by RT-PCR and Western blot, respectively.
  
  
  RESULTS
  Ginkgolide B and hypoxic preconditioning could both prolong the survival time of hypoxia under ordinary pressure,and significantly decreased the degree of brain edema. Besides ginkgolide B and hypoxic preconditioning could both up-regulate the expression of RTP801mRNA and EPO.
  
  
  CONCLUSIONS
  Ginkgolide B has the similar effect to hypoxic preconditioning against acute hypoxia. Both of these protective effects may be associated with the up-regulation of the expression of RTP801 mRNA and EPO.
authors.affiliation: Institute of Nautical Medicine, Nantong University, Nantong 226001, China.
authors.forename: Qian-qian
authors.initials: QQ
authors.lastname: Luo
authors.forename: Jun-xia
authors.initials: JX
authors.lastname: Yang
authors.forename: Xiao-min
authors.initials: XM
authors.lastname: Zhang
authors.forename: Jie-jia
authors.initials: JJ
authors.lastname: Li
authors.forename: Jia-xin
authors.initials: JX
authors.lastname: Shao
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000517:prevention & control; D004921:Erythropoietin / Q000378:metabolism; D005260:Female; D046934:Ginkgolides / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D019194:Ischemic Preconditioning / Q000379:methods*; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors; D015854:Up-Regulation / Q000187:drug effects
chemical_list: C000632146:Ddit4 protein, rat; D046934:Ginkgolides; D007783:Lactones; D012333:RNA, Messenger; D012097:Repressor Proteins; D014157:Transcription Factors; D004921:Erythropoietin; C045856:ginkgolide B