title: Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease.
abstract: OBJECTIVE
  To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Northern Manhattan, New York.
  
  
  METHODS
  One thousand one hundred thirty elderly individuals free of cognitive impairment at baseline.
  
  
  METHODS
  High-density lipoprotein cholesterol (HDL-C) levels.
  
  
  RESULTS
  Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03). In addition, higher levels of total and non-HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOE e4 genotype.
  
  
  CONCLUSIONS
  High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.
authors.affiliation: Gertrude H. Sergievsky Center, Columbia University, New York, NY 10032, USA. cr2101@columbia.edu
authors.forename: Christiane
authors.initials: C
authors.lastname: Reitz
authors.forename: Ming-Xin
authors.initials: MX
authors.lastname: Tang
authors.forename: Nicole
authors.initials: N
authors.lastname: Schupf
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Manly
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
authors.forename: José A
authors.initials: JA
authors.lastname: Luchsinger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism*; D001057:Apolipoproteins E; D008078:Cholesterol, LDL / Q000378:metabolism; D003072:Cognition Disorders / Q000150:complications / Q000378:metabolism; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D016016:Proportional Hazards Models; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL