title: Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity.
abstract: The finding of new PXR modulators as potential leads for treatment of human disorders characterized by dysregulation of innate immunity and with inflammation is of wide interest. In this paper, we report the identification of the first example of natural marine PXR agonists, solomonsterols A and B, from a Theonella swinhoei sponge. The structures were determined by interpretation of NMR and ESIMS data, and the putative binding mode to PXR has been obtained through docking calculations.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Carmen
authors.initials: C
authors.lastname: Festa
authors.forename: Simona
authors.initials: S
authors.lastname: De Marino
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: D'Auria
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bifulco
authors.forename: Barbara
authors.initials: B
authors.lastname: Renga
authors.forename: Stefano
authors.initials: S
authors.lastname: Fiorucci
authors.forename: Sylvain
authors.initials: S
authors.lastname: Petek
authors.forename: Angela
authors.initials: A
authors.lastname: Zampella
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002757:Cholanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008958:Models, Molecular; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid / Q000819:agonists* / Q000737:chemistry; D013463:Sulfuric Acid Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047232:Theonella / Q000737:chemistry*; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: C562251:24-norcholan-2,3,24-tryl-2,3,23-sulfuric acid; D000893:Anti-Inflammatory Agents; D002757:Cholanes; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid; D013463:Sulfuric Acid Esters; C561233:cholan-2,3,24-tryl-2,3,24-trisulfate