title: Male meiosis: Y keep it silenced?
abstract: What drives defective spermatocytes into apoptosis during mid-pachytene? A recent study identifies the first mid-pachytene 'killer' genes: two Y-linked transcription factors, the Zfy1/2 gene pair, must be silenced to avoid apoptosis.
authors.affiliation: Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Fiedlerstr. 42, MTZ, D-01307 Dresden, Germany.
authors.forename: Attila
authors.initials: A
authors.lastname: Tóth
authors.forename: Rolf
authors.initials: R
authors.lastname: Jessberger
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D005260:Female; D020868:Gene Silencing; D006801:Humans; D008297:Male; D008540:Meiosis; D013090:Spermatocytes / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics; D014998:Y Chromosome
chemical_list: D014157:Transcription Factors