title: Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS.
abstract: The Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS) is a national research resource supported by the National Center for Research Resources of the US National Institutes of Health. MacCHESS is pursuing several research initiatives designed to benefit both CHESS users and the wider structural biology community. Three initiatives are presented in further detail: microcrystallography, which aims to improve the collection of diffraction data from crystals a few micrometers across, or small well diffracting regions of inhomogeneous crystals, so as to obtain high-resolution structures; pressure cryocooling, which can stabilize transient structures and reduce lattice damage during the cooling process; and BioSAXS (small-angle X-ray scattering on biological solutions), which can extract molecular shape and other structural information from macromolecules in solution.
authors.affiliation: MacCHESS, Cornell University, Ithaca, NY 14853, USA. ue22@cornell.edu
authors.forename: Ulrich
authors.initials: U
authors.lastname: Englich
authors.forename: Irina A
authors.initials: IA
authors.lastname: Kriksunov
authors.forename: Richard A
authors.initials: RA
authors.lastname: Cerione
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cook
authors.forename: Richard
authors.initials: R
authors.lastname: Gillilan
authors.forename: Sol M
authors.initials: SM
authors.lastname: Gruner
authors.forename: Qingqui
authors.initials: Q
authors.lastname: Huang
authors.forename: Chae Un
authors.initials: CU
authors.lastname: Kim
authors.forename: William
authors.initials: W
authors.lastname: Miller
authors.forename: Soren
authors.initials: S
authors.lastname: Nielsen
authors.forename: David
authors.initials: D
authors.lastname: Schuller
authors.forename: Scott
authors.initials: S
authors.lastname: Smith
authors.forename: Doletha M E
authors.initials: DM
authors.lastname: Szebenyi
mesh_terms: D003080:Cold Temperature; D018360:Crystallography, X-Ray / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry*; D008967:Molecular Biology; D011312:Pressure; D053838:Scattering, Small Angle; D012996:Solutions / Q000737:chemistry; D017356:Synchrotrons; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D046911:Macromolecular Substances; D012996:Solutions