title: Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties.
abstract: Three, structurally characterised, bis-phen Cu(II) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)](2) and Poly[d(G-C)](2) binding.
authors.affiliation: The inorganic pharmaceutical and biomimetic research centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin, 8, Ireland. andrew.kellett@dit.ie
authors.forename: Andrew
authors.initials: A
authors.lastname: Kellett
authors.forename: Mark
authors.initials: M
authors.lastname: O'Connor
authors.forename: Malachy
authors.initials: M
authors.lastname: McCann
authors.forename: Mary
authors.initials: M
authors.lastname: McNamara
authors.forename: Patrick
authors.initials: P
authors.lastname: Lynch
authors.forename: Georgina
authors.initials: G
authors.lastname: Rosair
authors.forename: Vickie
authors.initials: V
authors.lastname: McKee
authors.forename: Bernie
authors.initials: B
authors.lastname: Creaven
authors.forename: Maureen
authors.initials: M
authors.lastname: Walsh
authors.forename: Siobhan
authors.initials: S
authors.lastname: McClean
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Foltyn
authors.forename: Denis
authors.initials: D
authors.lastname: O'Shea
authors.forename: Orla
authors.initials: O
authors.lastname: Howe
authors.forename: Michael
authors.initials: M
authors.lastname: Devereux
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000378:metabolism*; D008958:Models, Molecular; D010618:Phenanthrolines / Q000737:chemistry*; D010795:Phthalic Acids / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010618:Phenanthrolines; D010795:Phthalic Acids; D003300:Copper; D004247:DNA