title: Chemical composition and antidiabetic activity of Opuntia Milpa Alta extracts.
abstract: Three new compounds, 1-3, and 20 known compounds were isolated from the AcOEt and BuOH extract of edible Opuntia Milpa Alta. The petroleum ether extract was examined by GC and MS. A total of 26 compounds were identified, representing 95.6% of the total extract, phytosterol (36.03%) being the most abundant component, and polyunsaturated fatty acids (18.57%) represented the second largest group, followed by phytol (12.28%), palmitic acid, palmitate (13.54%), vitamin E (4.51%), and other compounds (7.47%). The effects of various extracts from edible Opuntia Milpa Alta (petroleum ether extract, AcOEt extract, BuOH extract, aqueous extract, H₂O parts) and the positive control (received dimethylbiguanide) were tested on streptozotocin (STZ)-induced diabetic mice. The results indicated that all the treatment groups could significantly decrease blood glucose levels in STZ-induced diabetic mice compared to the model control group (P<0.01), except the aqueous extract group (P<0.05). Especially, the petroleum ether extract group and the positive control group showed remarkable decrease of blood glucose levels. Taken together, the results indicate that the petroleum ether extract is the major hypoglycemic part in edible Opuntia Milpa Alta, which may be developed to a potential natural hypoglycemic functional ingredient.
authors.affiliation: Department of Medicinal Chemistry, Second Military Medical University, Shanghai, P R China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Luo
authors.forename: Wannian
authors.initials: W
authors.lastname: Zhang
authors.forename: Chunquan
authors.initials: C
authors.lastname: Sheng
authors.forename: Chengjian
authors.initials: C
authors.lastname: Zheng
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Yao
authors.forename: Zhenyuan
authors.initials: Z
authors.lastname: Miao
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D008401:Gas Chromatography-Mass Spectrometry; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D029747:Opuntia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013644:Tartrates / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013644:Tartrates