title: Amantadine-associated corneal edema treated with descemet's stripping automated endothelial keratoplasty.
abstract: The authors report the successful use of Descemet's stripping automated endothelial keratoplasty (DSAEK) to treat a 45-year-old woman with amantadine-associated corneal edema. Discontinuation of the medication and treatment with corticosteroids did not result in resolution of the edema. The patient underwent sequential phakic DSAEK in both eyes with significant anatomic, visual, and functional improvement. Histopathologic analysis of Descemet's membrane by light microscopy revealed a paucity of endothelial cells. This case highlights the importance of considering amantadine toxicity in the differential diagnosis of corneal edema without an identifiable ocular cause and suggests the utility of DSAEK in the treatment of this rare condition.
authors.affiliation: Cole Eye Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Hood
authors.forename: Roger H S
authors.initials: RH
authors.lastname: Langston
authors.forename: Lynn R
authors.initials: LR
authors.lastname: Schoenfield
authors.forename: William J
authors.initials: WJ
authors.lastname: Dupps
mesh_terms: D000547:Amantadine / Q000009:adverse effects* / Q000627:therapeutic use; D001331:Automation; D015715:Corneal Edema / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery*; D057111:Descemet Stripping Endothelial Keratoplasty; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000547:Amantadine