title: [Effects of simulated hypoxia on dielectric properties of mouse erythrocytes].
abstract: OBJECTIVE
  To explore the influence of simulated altitude hypoxia on dielectric properties of mouse erythrocytes.
  
  
  METHODS
  Experimental animals were divided into the plain control group(control) and simulated altitude hypoxia group (altitude). The AC impedance of mouse erythrocytes was measured with the Agilent 4294A impedance analyzer, the influence of simulated altitude hypoxia on dielectric properties of mouse erythrocytes was observed by cell dielectric spectroscopy, Cole-Cole plots, loss factor spectrum, loss tangent spectrum, and curve fitting analysis of Cole-Cole equation.
  
  
  RESULTS
  After mice were exposed to hypoxia at simulated 5000 m altitude for 4 weeks, permittivity at low frequency (epsilonl) and dielectric increment (deltaepsilon) increased 57% and 59% than that of control group respectively, conductivity at low frequency (kappal) and conductivity at high frequency (kappah) reduced 49% and 11% than that of control group respectively.
  
  
  CONCLUSIONS
  The simulated altitude hypoxia could arise to increase dielectric capability and depress conductive performance on mouse erythrocytes.
authors.affiliation: Institute of Physiology and Pharmacology, Medical School of Ningho University, Ningbo 315211, China. maqing@nbu.edu.cn
authors.forename: Qing
authors.initials: Q
authors.lastname: Ma
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Tang
authors.forename: Qin-Wen
authors.initials: QW
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000531:Altitude; D000818:Animals; D003198:Computer Simulation; D004553:Electric Conductivity; D017097:Electric Impedance; D004563:Electrochemistry / Q000379:methods; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013057:Spectrum Analysis / Q000379:methods*