title: Phosphate transport in the kidney.
abstract: In kidneys of mammals, filtered phosphate ions (Pi) are reabsorbed along the proximal tubules. Transcellular transport of phosphate is initiated by several apically localized sodium-dependent Pi cotransporters (Na/Pi-cotransporters) that belong to the SLC 20 (SLC20A2) and 34 (SLC34A1, SLC34A3) families. Apical abundance of these Na/Pi-cotransporters is adjusted by numerous hormones/phosphatonins and metabolic factors in order to adjust the extent of renal Pi reabsorption according to body needs. Acute hormonal regulation of Pi reabsorption occurs mainly by a change of the abundance of SLC34A1 (NaPi-IIa) via modulation of the interaction of NaPi-IIa with the PDZ-protein NHERF1.
authors.affiliation: Institute of Physiology and Centre of Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
authors.forename: Heini
authors.initials: H
authors.lastname: Murer
authors.forename: Jürg
authors.initials: J
authors.lastname: Biber
mesh_terms: D000042:Absorption; D000818:Animals; D004298:Dopamine / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000502:physiology; D010710:Phosphates / Q000008:administration & dosage / Q000378:metabolism*; D010750:Phosphoproteins / Q000502:physiology; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology; D050608:Sodium-Phosphate Cotransporter Proteins / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D010750:Phosphoproteins; D017923:Sodium-Hydrogen Exchangers; D050608:Sodium-Phosphate Cotransporter Proteins; C093376:sodium-hydrogen exchanger regulatory factor; D004298:Dopamine