title: In vitro interaction of itraconazole with amphotericin B, caspofungin, and terbinafine against clinical isolates of Trichosporon asahii.
abstract: Treatment of disseminated trichosporosis is still challenging. Itraconazole is a widely used broad-spectrum antifungal drug. In vitro interactions of itraconazole (ICZ) with amphotericin B (AMB), caspofungin (CAS), and terbinafine (TBF) against 18 clinical isolates of Trichosporon asahii were assessed by chequerboard microdilution method. ICZ combined with CAS showed the highest percentage of synergistic effect (72.2%), followed by ICZ/AMB (11%) and ICZ/TBF (11%) combination. Antagonistic effect was not observed. This study demonstrates that itraconazole can enhance the antifungal activity of CAS against T. asahii, suggesting that this combination may be a potential strategy for treating disseminated trichosporosis.
authors.affiliation: Department of Dermatology, Peking University People's Hospital, No. 11, Xizhimen South Street, West District, Beijing, 100044, People's Republic of China.
authors.forename: Houmin
authors.initials: H
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Qiao
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wan
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D000077336:Caspofungin; D004347:Drug Interactions; D054714:Echinocandins / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D009281:Naphthalenes / Q000494:pharmacology*; D000077291:Terbinafine; D014250:Trichosporon / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D000666:Amphotericin B; D000077336:Caspofungin; D000077291:Terbinafine