title: Experimental models for assaying microvascular endothelial cell pathophysiology in stroke.
abstract: It is important to understand the molecular mechanisms underlying neuron death following stroke in order to develop effective neuroprotective strategies. Since studies on human stroke are extremely limited due to the difficulty in collecting post-mortem tissue at different time points after the onset of stroke, brain ischaemia research focuses on information derived from in-vitro models of neuronal death through ischaemic injury [1]. This review aims to provide an update on the different in-vitro stroke models with brain microvascular endothelial cells that are currently being used. These models provide a physiologically relevant tool to screen potential neuroprotective drugs in stroke and to study the molecular mechanisms involved in brain ischaemia.
authors.affiliation: Department of Neurology, Girona Biomedical Research Institute (IdiBGi), Dr. Josep Trueta University Hospital, Av de França s/n, 17007 Girona, Spain. scamos.girona.ics@gencat.cat
authors.forename: Susanna
authors.initials: S
authors.lastname: Camós
authors.forename: Judith
authors.initials: J
authors.lastname: Mallolas
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D016923:Cell Death; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D055806:Microvessels / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008955:Models, Cardiovascular; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use; D020521:Stroke / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*
chemical_list: D018696:Neuroprotective Agents