title: Direct synthesis of 1-indanones via Pd-catalyzed olefination and ethylene glycol-promoted aldol-type annulation cascade.
abstract: A wide range of multisubstituted 1-indanones of potential pharmaceutical use were synthesized in a one-pot fashion in moderate to excellent yields via palladium catalysis in ethylene glycol. The Heck reaction first installs an enol functionality on the aromatic ring; this is followed by an ethylene glycol promoted aldol-type annulation with a neighboring carbonyl group, resulting in the formation of various 1-indanones.
authors.affiliation: Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK.
authors.forename: Jiwu
authors.initials: J
authors.lastname: Ruan
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Iggo
authors.forename: Jianliang
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D019855:Ethylene Glycol / Q000737:chemistry*; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000475:Alkenes; D007189:Indans; D010165:Palladium; C116609:3-hydroxybutanal; D019855:Ethylene Glycol