title: Successively-responsive drug-carrier vesicles assembled by 'supramolecular amphiphiles'.
abstract: Novel vesicles assembled by 'supramolecular amphiphiles' based on the inclusion complexes between 1 and β-CDs (β-CD and HP-β-CD) were found to carry drugs and be successively-responsive to external stimuli for the first time. These vesicles were observed by TEM and SEM and confirmed by DLS. The formation patterns of 'supramolecular amphiphiles' characterized by UV and NMR can be controlled by choosing different hosts. Unlike traditional drug delivery and releasing systems, the 'useless' inclusion complexes 1·β-CDs in thinking formula can assemble into vesicles to carry both cytotoxic 1 and drugs (piroxicam and ampicillin) at one time, confirmed by TEM, UV, and NMR data. Also the vesicles assembled by 1·β-CDs can be successively-responsive to acidifying and oxidizing, and release drugs and cytotoxic compounds in order.
authors.affiliation: School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, PR China.
authors.forename: Huacheng
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhaona
authors.initials: Z
authors.lastname: Liu
authors.forename: Feifei
authors.initials: F
authors.lastname: Xin
authors.forename: Wei
authors.initials: W
authors.lastname: An
authors.forename: Aiyou
authors.initials: A
authors.lastname: Hao
authors.forename: Jianye
authors.initials: J
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.forename: Lizhen
authors.initials: L
authors.lastname: Sun
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhao
authors.forename: Yueming
authors.initials: Y
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Kong
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000667:Ampicillin / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D010894:Piroxicam / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D013501:Surface-Active Agents; D047392:beta-Cyclodextrins; D010894:Piroxicam; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000667:Ampicillin