title: Human platelet FcγRIIA and phagocytes in immune-complex clearance.
abstract: In addition to their primary role in hemostasis and wound healing, platelets play important roles in a multitude of physiological functions including immune and inflammatory responses. We present data that platelets, by virtue of their expression of the human specific FcγR, FcγRIIA, bind IgG complexes in vivo and that circulating phagocytes from healthy individuals internalize platelets in vivo. Human platelets, as a consequence of their expression of FcγRIIA, may thus, contribute to the clearance of IgG-containing complexes from the circulation.
authors.affiliation: Division of Hematology/Oncology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, United States. zyh@mail.med.upenn.edu
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Huang
authors.forename: Paul
authors.initials: P
authors.lastname: Chien
authors.forename: Zena K
authors.initials: ZK
authors.lastname: Indik
authors.forename: Alan D
authors.initials: AD
authors.lastname: Schreiber
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001792:Blood Platelets / Q000166:cytology / Q000276:immunology* / Q000648:ultrastructure; D002465:Cell Movement; D004705:Endocytosis / Q000276:immunology; D005434:Flow Cytometry; D006262:Health; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000648:ultrastructure; D010586:Phagocytes / Q000166:cytology / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D011485:Protein Binding; D017452:Receptors, IgG / Q000276:immunology*; D014019:Tissue Donors
chemical_list: D000936:Antigen-Antibody Complex; C080568:Fc gamma receptor IIA; D007074:Immunoglobulin G; D017452:Receptors, IgG