title: Vascular endothelial growth factor +936C/T and +405G/C polymorphisms and cancer risk: a meta-analysis.
abstract: OBJECTIVE
  A number of investigators have studied the possible association between vascular endothelial growth factor (VEGF) polymorphisms and cancer risk, but the results have been conflicting. To examine the risk of cancer associated with the +936C/T and +405G/C polymorphisms of VEGF, all available studies were considered in the present meta-analysis.
  
  
  METHODS
  We performed a computerized search of PubMed and Embase database for relevant studies. Articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using the statistical techniques of meta-analysis.
  
  
  RESULTS
  Overall, the 936C allele showed no significant effect on cancer risk compared with the 936T allele in all subjects (OR = 0.77, 95% CI = 0.53-1.14; random model). Similarly, no significant effect of 405G allele compared with 405C on cancer risk was found (OR = 1.08, 95% CI = 0.94-1.24; random model). It indicated that the VEGF +936C/T and +405G/C polymorphisms might not be risk factors for cancer, but the 936C allele was associated with a decreased risk of oral cancer (OR = 0.72, 95% CI = 0.53-0.97; fixed model).
  
  
  CONCLUSIONS
  The evidence from our meta-analysis supports that there was an association between 936C allele and decreased oral cancer risk, although no evidence of association between VEGF +936C/T or +405G/C polymorphism and cancer was observed in all examined patients. Further studies based on larger, stratified population are required to explore the role of VEGF polymorphisms on cancer risk.
authors.affiliation: Department of Respiratory Medicine, The Affiliated Hospital-School of Medicine, Ningbo University, Ningbo, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Cao
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Fang
authors.forename: Tao
authors.initials: T
authors.lastname: Ying
authors.forename: Shi-Fang
authors.initials: SF
authors.lastname: Sun
authors.forename: Dan
authors.initials: D
authors.lastname: Lv
authors.forename: Zhong-Bo
authors.initials: ZB
authors.lastname: Chen
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Ma
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Yu
authors.forename: Qun-Li
authors.initials: QL
authors.lastname: Ding
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Shu
authors.forename: Zai-Chun
authors.initials: ZC
authors.lastname: Deng
mesh_terms: D000483:Alleles; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D039781:PubMed; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A