title: Fetuses with ventriculomegaly diagnosed in the second trimester of pregnancy by in utero MR imaging: what happens in the third trimester?
abstract: OBJECTIVE
  Although MR imaging of the fetal brain has been shown to provide additional diagnostic information, the optimal timing of the study and the value of repeat studies remain unclear. The primary purpose of this study was to look for structural abnormalities of the fetal brain shown at 30-32 weeks' gestational age but not on the 20-24 weeks' study in fetuses originally referred with isolated VM. In particular, we wished to study the hypothesis that third-trimester fetal MR imaging studies would not show extra brain abnormalities compared with the second-trimester studies in this group.
  
  
  METHODS
  Ninety-nine women were admitted for a fetal MR study between 20-24 weeks' gestational age, and 46 of these women agreed to return for a second MR imaging examination at 30-32 weeks' gestational age. The other women were either lost to follow-up or declined the invitation to return. Two experienced observers measured the width of the trigones, and the results were compared, to test reliability. Changes in the degree of VM are reported along with changes in the diagnosis of structural brain abnormalities.
  
  
  RESULTS
  There was excellent reproducibility of trigone measurements between the 2 observers, with a mean absolute difference of <1 mm in the 40 fetuses that were ultimately shown to have isolated VM. Twenty-eight of 40 fetuses studied had mild VM on the first iuMR imaging examination, but in just more than half, the category of VM changed between the studies (5 had become normal-sized, 7 had progressed to moderate, 3 had become severe, and 13 remained mild). In 1 case, hypogenesis of the corpus callosum was recognized at 30-32 weeks but had not been reported on the 20-24 weeks' examination; the other 5 fetuses had brain pathology recognized on both fetal MR studies.
  
  
  CONCLUSIONS
  Trigone measurements can be made in a highly repeatable fashion on iuMR imaging. We have not shown any major advantage in repeating iuMR imaging at 30-32 weeks' gestation in terms of improved diagnosis of other structural brain abnormalities. With the converse of that argument, however, our data suggest that there is no advantage in delaying iuMR imaging studies to 30-32 weeks in the hope of improving detection rates.
authors.affiliation: Academic Unit of Radiology, University of Sheffield, United Kingdom. p.griffiths@sheffield.ac.uk
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
authors.forename: J E
authors.initials: JE
authors.lastname: Morris
authors.forename: G
authors.initials: G
authors.lastname: Mason
authors.forename: S A
authors.initials: SA
authors.lastname: Russell
authors.forename: M N J
authors.initials: MN
authors.lastname: Paley
authors.forename: E H
authors.initials: EH
authors.lastname: Whitby
authors.forename: M J
authors.initials: MJ
authors.lastname: Reeves
mesh_terms: D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity