title: Induction of a Th-1-biased IgG subclass response against equine herpesvirus type 1 in horses previously infected with type 4 virus.
abstract: An immunoglobulin G (IgG) subclass response against equine herpesvirus type 1 (EHV-1) infection was investigated in horses that were naïve to EHV-1/4 and those that had previously been exposed to EHV-4. The IgG subclass response was determined by an ELISA using EHV-1-specific recombinant gG protein as an antigen. In most horses naïve to EHV-1/4, IgGa, IgGb, and IgG(T) were induced after experimental infection with EHV-1. In contrast, a subclass response dominated by IgGa and IgGb, with no apparent increase in IgG(T), was observed after EHV-1 infection in horses previously infected with EHV-4. Horses naturally infected with EHV-1 in the field showed similar responses. These results indicated that pre-infection with EHV-4 induced a Th-1-biased IgG subclass response against subsequent EHV-1 infection.
authors.affiliation: Epizootic Research Center, Equine Research Institute, Japan Racing Association, 1400–4 Shiba, Shimotsuke, Tochigi 329–0412, Japan. bannai@epizoo.equinst.go.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Bannai
authors.forename: Koji
authors.initials: K
authors.lastname: Tsujimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
authors.forename: Manabu
authors.initials: M
authors.lastname: Nemoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Takeo
authors.initials: T
authors.lastname: Sugiura
authors.forename: Ken
authors.initials: K
authors.lastname: Maeda
authors.forename: Tomio
authors.initials: T
authors.lastname: Matsumura
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D006566:Herpesviridae Infections / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D023141:Herpesvirus 4, Equid / Q000276:immunology*; D006734:Horse Diseases / Q000276:immunology / Q000821:virology*; D006736:Horses; D007074:Immunoglobulin G / Q000097:blood*; D018417:Th1 Cells / Q000502:physiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G