title: The impact of dose calculation algorithms on partial and whole breast radiation treatment plans.
abstract: BACKGROUND
  This paper compares the calculated dose to target and normal tissues when using pencil beam (PBC), superposition/convolution (AAA) and Monte Carlo (MC) algorithms for whole breast (WBI) and accelerated partial breast irradiation (APBI) treatment plans.
  
  
  METHODS
  Plans for 10 patients who met all dosimetry constraints on a prospective APBI protocol when using PBC calculations were recomputed with AAA and MC, keeping the monitor units and beam angles fixed. Similar calculations were performed for WBI plans on the same patients. Doses to target and normal tissue volumes were tested for significance using the paired Student's t-test.
  
  
  RESULTS
  For WBI plans the average dose to target volumes when using PBC calculations was not significantly different than AAA calculations, the average PBC dose to the ipsilateral breast was 10.5% higher than the AAA calculations and the average MC dose to the ipsilateral breast was 11.8% lower than the PBC calculations. For ABPI plans there were no differences in dose to the planning target volume, ipsilateral breast, heart, ipsilateral lung, or contra-lateral lung. Although not significant, the maximum PBC dose to the contra-lateral breast was 1.9% higher than AAA and the PBC dose to the clinical target volume was 2.1% higher than AAA. When WBI technique is switched to APBI, there was significant reduction in dose to the ipsilateral breast when using PBC, a significant reduction in dose to the ipsilateral lung when using AAA, and a significant reduction in dose to the ipsilateral breast and lung and contra-lateral lung when using MC.
  
  
  CONCLUSIONS
  There is very good agreement between PBC, AAA and MC for all target and most normal tissues when treating with APBI and WBI and most of the differences in doses to target and normal tissues are not clinically significant. However, a commonly used dosimetry constraint, as recommended by the ASTRO consensus document for APBI, that no point in the contra-lateral breast volume should receive >3% of the prescribed dose needs to be relaxed to >5%.
authors.affiliation: Department of Medical Physics, BC Cancer Agency-Vancouver Island Centre, Victoria, British Columbia, Canada. pbasran@bccancer.bc.ca
authors.forename: Parminder S
authors.initials: PS
authors.lastname: Basran
authors.forename: Sergei
authors.initials: S
authors.lastname: Zavgorodni
authors.forename: Tanya
authors.initials: T
authors.lastname: Berrang
authors.forename: Ivo A
authors.initials: IA
authors.lastname: Olivotto
authors.forename: Wayne
authors.initials: W
authors.lastname: Beckham
mesh_terms: D000465:Algorithms; D001940:Breast / Q000528:radiation effects; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012189:Retrospective Studies