title: [Association of lipoprotein lipase gene Hind III and S447X polymorphisms in metabolic syndrome patients among Kazakh and Han ethnics from Xinjiang].
abstract: OBJECTIVE
  To investigate the association of lipoprotein lipase gene Hind III and S447X polymorphisms with metabolic syndrome among Kazakh and Han ethnicities in Xinjiang.
  
  
  METHODS
  PCR-RFLP was used to detect 802 subjects' lipoprotein lipase Hind III and S447X genotypes (including 201 controls and 200 metabolic syndrome patients in Kazakh and Han ethnicities, respectively).
  
  
  RESULTS
  (1) Frequencies of H+H-/H-H- genotype (32.50% vs. 47.76%), H- allele (18.00% vs. 28.86%), SX/XX genotype (8.00% vs. 22.39%) and X allele (4.00% vs. 12.44%) for metabolic syndrome in Han ethnicity were all significantly lower than those in controls (P < 0.01). (2) The frequencies of H+H-/H-H- genotype (33.50% vs. 46.80%), H- allele (22.00% vs. 28.60%), SX/XX genotype (10.50% vs. 22.90%) and X allele (5.50% vs. 12.44%) in patients with metabolic syndrome in Kazakh were all significantly lower than those for controls (P < 0.01). (3) The frequencies of lipoprotein lipase gene Hind III and S447X genotypes and alleles in Kazakh were not significantly different from Han (all P > 0.05). (4) The levels of waist circumference, systolic blood pressure, diastolic blood pressure, triglyceride and FPG in H+H-/H-H- and SX/XX genotype were significantly lower than those in H+H+ and SS genotype. HDL-C was significantly higher than that in H+H+ and SS genotype (P < 0.05). (5) The frequencies of H+H+ and SS genotype increased along with the increase in number of metabolic syndrome component.
  
  
  CONCLUSIONS
  The lipoprotein lipase gene Hind III and S447X polymorphisms were associated with metabolic syndrome risk in Kazakh, and H+H-/H-H- genotype, H- allele, SX/XX genotype and X allele might have served as protective factors of metabolic syndrome. H+H-/H-H- and SX/XX genotype seemed to have had beneficial effects for all the metabolic syndrome components, and the frequencies of H+H+ and SS genotype were increasing along with the increase of number in the metabolic syndrome components.
authors.affiliation: Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China. pge888@sina.com
authors.forename: Shu-xia
authors.initials: SX
authors.lastname: Guo
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Yang
authors.forename: Heng
authors.initials: H
authors.lastname: Guo
authors.forename: Jing-yu
authors.initials: JY
authors.lastname: Zhang
authors.forename: Jing-xia
authors.initials: JX
authors.lastname: Tang
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Rui
authors.forename: Ru-lin
authors.initials: RL
authors.lastname: Ma
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000208:ethnology / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D008071:Lipoprotein Lipase