title: Alterations in regional homogeneity of baseline brain activity in pediatric temporal lobe epilepsy.
abstract: Recent findings on intracortical EEG measurements show that the synchrony of localized neuronal networks is altered in epileptogenesis, leading to generalized seizure activity via connector hubs in the neuronal networks. Regional homogeneity (ReHo) analysis of blood oxygen level-dependent (BOLD) signals has demonstrated localized signal synchrony and disease-related alterations in a number of instances. We wanted to find out whether the ReHo of resting-state activity can be used to detect regional signal synchrony alterations in children with non-lesional temporal lobe epilepsy (TLE). Twenty-one TLE patients were compared with age and gender-matched healthy controls. Significantly increased ReHo was discovered in the posterior cingulate gyrus and the right medial temporal lobe of the patients, and they also had significantly decreased ReHo in the cerebellum compared with the healthy controls. However, the alterations in ReHo differed between the patients with normal and abnormal interictal EEGs, the latter showing significantly increased ReHo in the right fusiform gyrus and significantly decreased ReHo in the right medial frontal gyrus relative to the controls, while those with normal EEGs had significantly increased ReHo in the right inferior temporal gyrus and the left posterior cingulate gyrus. We conclude that altered BOLD signal synchrony can be detected in the cerebral and cerebellar cortices of children with TLE even in the absence of interictal EEG abnormalities.
authors.affiliation: Department of Pediatrics, Oulu University Hospital, Oulu, Finland. katariina.mankinen@oulu.fi
authors.forename: Katariina
authors.initials: K
authors.lastname: Mankinen
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Long
authors.forename: Jyri-Johan
authors.initials: JJ
authors.lastname: Paakki
authors.forename: Marika
authors.initials: M
authors.lastname: Harila
authors.forename: Seppo
authors.initials: S
authors.lastname: Rytky
authors.forename: Osmo
authors.initials: O
authors.lastname: Tervonen
authors.forename: Juha
authors.initials: J
authors.lastname: Nikkinen
authors.forename: Tuomo
authors.initials: T
authors.lastname: Starck
authors.forename: Jukka
authors.initials: J
authors.lastname: Remes
authors.forename: Heikki
authors.initials: H
authors.lastname: Rantala
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
authors.forename: Vesa
authors.initials: V
authors.lastname: Kiviniemi
mesh_terms: D000293:Adolescent; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen; D010372:Pediatrics
chemical_list: D010100:Oxygen