title: [A case of capecitabine-resistant recurrent breast cancer found to be responsive to S-1].
abstract: Thirteen months following surgery, local recurrence and multiple lung metastases occurred. Hormone therapy was continued following the recurrence but was found to be ineffective, so the patient was referred to our hospital 9 months after the recurrence. Capecitabine-based chemotherapy was administered but found to be ineffective; 3 months later, the anti-cancer drug was changed to S-1. After 3 months of S-1 administration, a CT scan showed a marked reduction in sites of recurrence and metastasis, making it possible to control progression of the disease over a longer period. No critical adverse reactions were observed, suggesting that S-1 can be useful and safe for the treatment of capecitabine-resistant recurrent breast cancer.
authors.affiliation: Dept. of Surgery, Matsuyama Red Cross Hospital.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Inoue
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yano
authors.forename: Rinsyun
authors.initials: R
authors.lastname: Shimabukuro
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishizaki
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Murakami
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004338:Drug Combinations; D019008:Drug Resistance, Neoplasm; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000069287:Capecitabine; D005472:Fluorouracil