title: Silver nanocluster aptamers: in situ generation of intrinsically fluorescent recognition ligands for protein detection.
abstract: We have synthesized an intrinsically fluorescent recognition ligand that combines the high fluorescence quantum yield (>50%) of oligonucleotide templated AgNCs with the specificity and strong binding affinity of DNA aptamers for their target proteins, to develop a new strategy for detection of specific proteins.
authors.affiliation: MPA-CINT, Mail Stop, K771, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
authors.forename: Jaswinder
authors.initials: J
authors.lastname: Sharma
authors.forename: Hsin-Chih
authors.initials: HC
authors.lastname: Yeh
authors.forename: Hyojong
authors.initials: H
authors.lastname: Yoo
authors.forename: James H
authors.initials: JH
authors.lastname: Werner
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Martinez
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D049329:Nanostructures / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011789:Quantum Theory; D012834:Silver / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013917:Thrombin / Q000032:analysis*
chemical_list: D052157:Aptamers, Nucleotide; D008024:Ligands; D009841:Oligonucleotides; D012834:Silver; D013917:Thrombin