title: Cannabinoid hyperemesis syndrome: an underreported entity causing nausea and vomiting of pregnancy.
abstract: BACKGROUND
  In the western world, cannabis is the most widely used drug of abuse. Cannabinoid hyperemesis syndrome, which seems to be a rare paradoxical reaction in individuals with a particular predisposition, is characterized by cyclic severe nausea and vomiting in long-term cannabis users. While the symptoms are unresponsive to antiemetic drugs, compulsive hot baths result in a considerable symptom relief.
  
  
  METHODS
  We report the first case of cannabinoid hyperemesis syndrome in pregnancy. A 26-year-old patient was admitted to our clinic in the 10th week of gestation.
  
  
  CONCLUSIONS
  Before undertaking time-consuming and expensive medical examinations to rule out other medical reasons for therapy-resistant hyperemesis in pregnancy, obstetricians should determine whether compulsive bathing or showering provides symptomatic relief and ask specific questions regarding possible/suspected cannabis consumption.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Basel (UHB), Spitalstrasse 21, 4031 Basel, Switzerland.
authors.forename: Seraina M
authors.initials: SM
authors.lastname: Schmid
authors.forename: Olav
authors.initials: O
authors.lastname: Lapaire
authors.forename: Dorothy J
authors.initials: DJ
authors.lastname: Huang
authors.forename: Frank Edwin
authors.initials: FE
authors.lastname: Jürgens
authors.forename: Uwe
authors.initials: U
authors.lastname: Güth
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use; D001494:Baths; D002186:Cannabinoids / Q000009:adverse effects* / Q000652:urine; D005260:Female; D006801:Humans; D006875:Hydrotherapy / Q000379:methods; D006939:Hyperemesis Gravidarum / Q000139:chemically induced* / Q000188:drug therapy / Q000652:urine; D009325:Nausea / Q000139:chemically induced / Q000628:therapy; D011247:Pregnancy; D011261:Pregnancy Trimester, First
chemical_list: D000932:Antiemetics; D002186:Cannabinoids