title: Preoperative chemoradiation and extended pelvic lymphadenectomy for rectal cancer: Two distinct principles.
abstract: Extended pelvic lymphadenectomy (EPL) with total mesorectal excision (TME) has been reported to provide oncological benefit in lower rectal cancer in Japan. In Western countries EPL is not widely accepted because of frequent morbidity but instead preoperative chemoradiation (CRT) followed by TME has been established as a standard treatment for decreasing local recurrence. Recently, several studies have focused on the comparison between these two distinct therapeutic approaches in Western countries and Japan. A study comparing Dutch trial data and Japanese data revealed that EPL and RT are almost equivalent in decreasing local recurrence in lower rectal cancer as compared with TME alone. Considering that almost 45% survival can be achieved by EPL even in the presence of metastatic lateral lymph nodes (LLNs), EPL performed by experienced surgeons definitely contributes to decrease local recurrence. On the other hand, a randomized controlled trial in Japan that compared EPL with conventional TME following preoperative RT revealed that EPL is associated with a higher frequency of sexual and urinary dysfunction without oncological benefits in the presence of preoperative RT. On this point, preoperative CRT followed by conventional TME without EPL would be a better therapeutic approach in patients without evident metastatic LLNs. For future treatment, it would be desirable to have a narrower indication for EPL using full advantage of recent improvement in image diagnosis. Although objective comparison of these two principles between Japan and the West is difficult due to differences in patient groups, further studies would lead to the next great step towards future improvement in treating lower rectal cancer.
authors.affiliation: Tsuyoshi Konishi, Masatoshi Oya, Masashi Ueno, Hiroya Kuroyanagi, Yoshiya Fujimoto, Takashi Akiyoshi, Toshiharu Yamaguchi, Tetsuichiro Muto, Department of Gastroenterological Surgery, Cancer Institute Hospital, Tokyo, 135-8550, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Konishi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nagawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Oya
authors.forename: Masashi
authors.initials: M
authors.lastname: Ueno
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kuroyanagi
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiyoshi
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Tetsuichiro
authors.initials: T
authors.lastname: Muto