title: [Effect of one month treatment with dutasteride on transurethral resection of the prostate].
abstract: OBJECTIVE
  Evaluate the effect of dutasteride in perioperative bleeding during Transurethral Resection of Prostate (TURP).
  
  
  METHODS
  Forty consecutive patients with criteria for TURP were included. Finasteride/dutasteride use, renal impairment, prostate < 30 cc, age <50 were excluded. Patients were divided in 2 groups. Group 1: 24 consecutive patients treated with dutasteride 0.5 mg/day/30-days prior TURP. Group 2: 16 without treatment. Prostatic volume, difference in hemoglobin pre/post TURP, duration and amount of resected tissue were recorded. Surgeon was blinded.
  
  
  METHODS
  Multiple linear regression, Mann-Whitney and student t-tests were used.
  
  
  RESULTS
  In group 1, 33% (8) improved their lower urinary tract symptoms and skipped TURP. Mean Hemoglobin loss difference between groups was 0.11 gr/dl (CI 95% -0.55; 0.77, p=0.88). There was no statistical difference among variables. No positive or negative predictive values in the linear regression model.
  
  
  CONCLUSIONS
  Dutasteride did not significantly impact the studied variables in these non randomized and small sample size settings.
authors.affiliation: Servicio de Urología, Hospital Universitario «Dr. José E. González» UANL Monterrey, NL México.
authors.forename: J A
authors.initials: JA
authors.lastname: Arratia-Maqueo
authors.forename: R
authors.initials: R
authors.lastname: Garza-Cortés
authors.forename: L S
authors.initials: LS
authors.lastname: Gómez-Guerra
authors.forename: J R
authors.initials: JR
authors.lastname: Cortés-González
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000627:therapeutic use*; D000368:Aged; D001378:Azasteroids / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D000068538:Dutasteride; D006801:Humans; D008297:Male; D013997:Time Factors; D020728:Transurethral Resection of Prostate
chemical_list: D058891:5-alpha Reductase Inhibitors; D001378:Azasteroids; D000068538:Dutasteride