title: Neuroprotective effects of Eriobotrya japonica against β-amyloid-induced oxidative stress and memory impairment.
abstract: The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of neurodegenerative disorders. Eriobotrya japonica has been used to treat several diseases in East Asia. In this study, we investigated the protective effect of an E. japonica extract against Aβ peptide-induced oxidative stress. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay demonstrated that the E. japonica extract scavenged approximately 40% of DPPH radicals. Also, treatment of the E. japonica extract inhibited Aβ(1-42)-mediated neuronal cell death. Furthermore, treatment of E. japonica extract efficiently suppressed the increase in intracellular ROS triggered by the Aβ(1-42) peptide. Importantly, mice pre-treated with the E. japonica extract showed restoration of alternation behavior and reversal of Aβ(1-42)-induced memory impairment. Consequently, the E. japonica extract substantially inhibited the increase in lipid peroxidation and restored superoxide dismutase activity. These results suggest that E. japonica protects from oxidative stress and cognitive deficits induced by the Aβ peptide.
authors.affiliation: Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Severance Medical Research Institute, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, South Korea.
authors.forename: Mi-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Ah-Reum
authors.initials: AR
authors.lastname: Seong
authors.forename: Yoo-Hyun
authors.initials: YH
authors.lastname: Lee
authors.forename: Yung-Jae
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hum-Young
authors.initials: HY
authors.lastname: Baek
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kim
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Jun
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
mesh_terms: D000818:Animals; D031983:Eriobotrya / Q000502:physiology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008569:Memory Disorders / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress; D016716:PC12 Cells; D051381:Rats
chemical_list: D016166:Free Radical Scavengers; D018696:Neuroprotective Agents