title: The Coulter principle for analysis of subvisible particles in protein formulations.
abstract: The Coulter principle can be used for analysis of subvisible particles in protein formulations. The approach has several advantages including: an orthogonal operating principle, high sensitivity, ability to detect very small particles, excellent reproducibility, and high-resolution size information. This minireview discusses some of the important considerations that must be taken into account when utilizing the Coulter principle for subvisible particle analysis in protein formulations.
authors.affiliation: Particle Characterization Business Center, Beckman Coulter, Inc., 11800 SW 147th Ave, Miami, Florida 33196, USA. mnrhyner@beckman.com
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Rhyner
mesh_terms: D000465:Algorithms; D002021:Buffers; D004044:Dietary Proteins / Q000032:analysis*; D004553:Electric Conductivity; D005504:Food Analysis / Q000295:instrumentation*; D005526:Food, Formulated / Q000032:analysis*; D015233:Models, Statistical; D010316:Particle Size; D015203:Reproducibility of Results; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D002021:Buffers; D004044:Dietary Proteins; D012710:Serum Albumin, Bovine