title: [Anti-hypoxia protective role of the effective component extracted from angelia injection].
abstract: OBJECTIVE
  To investigate anti-hypoxia protective roles of the effective component extracted from angelia injection using hypoxia injury model in mice and ECV304 cells separately.
  
  
  METHODS
  The survival time of mice was observed separately under normobaric and hypobaric hypoxia. The activity of ECV304 cells was tested by MTT assay, and the mortality rate was examined by Trypan blue exclusion assay to evaluate the pharmacodynamic effects.
  
  
  RESULTS
  After exposed to hypoxia the survival time of mice was increased in medicine groups,compared with the control groups (P < 0.05). The cell survival rate was decreased and the cell mortality rate was increased after cells were exposed to hypoxia,while the cell survival rate was significantly increased (P < 0.01), and the cell mortality rate was significantly decreased (P < 0.1) in the medicine groups compared with the control groups.
  
  
  CONCLUSIONS
  The effective component extracted from angelia injection can protect against the injury induced by hypoxia.
authors.affiliation: Institute of Neuro-Science, Capital Medical University School of Basic Medical Sciences,Beijing 100069, China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wu
authors.forename: Tong
authors.initials: T
authors.lastname: Zhao
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Du
authors.forename: Lei
authors.initials: L
authors.lastname: Xiong
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Zhu
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice
chemical_list: C421565:2-(glucopyranosyloxymethyl)-5-hydroxymethylfuran; D004365:Drugs, Chinese Herbal; D005663:Furans; D006027:Glycosides