title: Another tier for caspase regulation: IAPs as NEDD8 E3 ligases.
abstract: Many inhibitor of apoptosis proteins (IAPs) function as E3 ligases to ubiquitinate important cell death proteins, including caspases. Broemer et al. (2010) report recently in Molecular Cell that IAPs can also inhibit caspases by promoting conjugation of the UBL NEDD8.
authors.affiliation: Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.
authors.forename: Sigi
authors.initials: S
authors.lastname: Benjamin
authors.forename: Hermann
authors.initials: H
authors.lastname: Steller