title: Genetic distance and markers used in linkage mapping.
abstract: In this chapter, we focus on maps and markers used for a linkage analysis. More detail regarding the actual linkage analysis methodology follows in Chapter 11. There are two major types of maps: genetic maps and physical maps. Genetic maps indicate the expected number of meiotic crossover events between two loci on a chromosome and are measured in centiMorgans (cM). Physical maps use molecular techniques, such as DNA sequencing, to determine the location of markers on a chromosome and are measured in base pairs (bp). Linkage analysis relies on genetic maps, and hence they are discussed in this chapter. In addition to a discussion of genetic maps and various map functions, we also discuss the selection of markers for a linkage analysis, including the more traditional microsatellite markers and the newer single nucleotide polymorphism (SNP) markers.
authors.affiliation: Genetic Epidemiology Division, Department of Biomedical Informatics, University of Utah, Salt Lake City, UT, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Allen-Brady
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Camp
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D008040:Genetic Linkage; D056426:Genetic Loci / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D010375:Pedigree; D020161:Physical Chromosome Mapping; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics
chemical_list: D005819:Genetic Markers