title: Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies.
abstract: OBJECTIVE
  in a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden.
  
  
  METHODS
  we examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies.
  
  
  RESULTS
  no significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13).
  
  
  CONCLUSIONS
  the single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations.
authors.affiliation: Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, the Sahlgrenska Academy, SE-413 45 Gothenburg, Sweden. sandra.olsson@neuro.gu.se
authors.forename: Sandra
authors.initials: S
authors.lastname: Olsson
authors.forename: Olle
authors.initials: O
authors.lastname: Melander
authors.forename: Katarina
authors.initials: K
authors.lastname: Jood
authors.forename: J Gustav
authors.initials: JG
authors.lastname: Smith
authors.forename: Håkan
authors.initials: H
authors.lastname: Lövkvist
authors.forename: Marketa
authors.initials: M
authors.lastname: Sjögren
authors.forename: Gunnar
authors.initials: G
authors.lastname: Engström
authors.forename: Bo
authors.initials: B
authors.lastname: Norrving
authors.forename: Arne
authors.initials: A
authors.lastname: Lindgren
authors.forename: Christina
authors.initials: C
authors.lastname: Jern
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*; D013548:Sweden