title: FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy.
abstract: This is the first case report of Candida glabrata-disseminated candidiasis describing the acquisition of echinocandin resistance following anidulafungin treatment. The initial isolates recovered were susceptible to echinocandins. However, during 27 days of anidulafungin treatment, two resistant strains were isolated (from the blood and peritoneal fluid). The resistant peritoneal fluid isolate exhibited a Ser663Pro mutation in position 1987 of FKS2 HS1 (hot spot 1), whereas the resistant blood isolate displayed a phenylalanine deletion (Phe659).
authors.affiliation: Department of Microbiology, Faculty of Medicine, Porto University, Alameda Professor Hernani Monteiro, 4200-319 Porto, Portugal. sqco@med.up.pt.
authors.forename: Sofia
authors.initials: S
authors.lastname: Costa-de-Oliveira
authors.forename: Isabel
authors.initials: I
authors.lastname: Marcos Miranda
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Silva
authors.forename: Ana
authors.initials: A
authors.lastname: Pinto E Silva
authors.forename: Rita
authors.initials: R
authors.lastname: Rocha
authors.forename: António
authors.initials: A
authors.lastname: Amorim
authors.forename: Acácio
authors.initials: A
authors.lastname: Gonçalves Rodrigues
authors.forename: Cidália
authors.initials: C
authors.lastname: Pina-Vaz
mesh_terms: D000368:Aged; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000627:therapeutic use*; D041221:Candida glabrata / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D025141:Drug Resistance, Fungal / Q000235:genetics; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D005964:Glucosyltransferases / Q000235:genetics*; D006801:Humans; D009154:Mutation
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin; D005964:Glucosyltransferases