title: [Predictors of adherence to treatment of chronic hepatitis C in drug-dependent inmate patients in four prisons in Barcelona, Spain].
abstract: BACKGROUND
  Drug addiction is not a contraindication to indicate treatment of chronic hepatitis C (CHC), but it has been observed that consumers are more abandon. To study the clinical outcome of hepatitis C treatment in inmate patients with a history in injecting drugs and to analyze which were the causes of abandon.
  
  
  METHODS
  A multicenter retrospective clinical trial including 162 inmate patients that underwent HCV therapy with pegylated interpheron and ribavirin between January 2003 and January 2008 was performed. It was found in medical history who completed treatment. We used a questionnaire to determine variables associated with discontinuation of treatment and multivariate analysis was performed using logistic regression to identify predictors.
  
  
  RESULTS
  82.7% were intravenous drug users, 21.7% had HIV coinfection and 20.5% were on methadone maintenance therapy. 91.4% completed the whole treatment; 33.1% admitted heroin and/or cocaine consumption during therapy and 7.9% admitted needle and syringe-sharing. Relapse in intravenous consumption in or out of prison was the only one predictive factor of treatment interruption (OR: 10.39, IC: 1.93-55.88; p = 0.006).
  
  
  CONCLUSIONS
  Only 9,6% of patients discontinued treatment. Drug use was the main cause of discontinuation of treatment. We recommend the treatment of drug addiction to reduce the discontinuations of treatment for chronic hepatitis C.
authors.affiliation: Servicios Médicos Penitenciarios, La Modelo, Barcelona. andres.marco.m@gmail.com
authors.forename: Andrés
authors.initials: A
authors.lastname: Marco Mouriño
authors.forename: Antonio
authors.initials: A
authors.lastname: da Silva Morán
authors.forename: Jordi
authors.initials: J
authors.lastname: Ortiz Seuma
authors.forename: Concepció
authors.initials: C
authors.lastname: Solé Carbó
authors.forename: Mercè
authors.initials: M
authors.lastname: Roget Alemany
authors.forename: Carmen
authors.initials: C
authors.lastname: Sarriera Gracia
authors.forename: Núria
authors.initials: N
authors.lastname: Teixidó Pérez
authors.forename: Pilar
authors.initials: P
authors.lastname: Robres Guillén
authors.forename: Rafael Alonso
authors.initials: RA
authors.lastname: Guerrero Moreno
mesh_terms: D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D055118:Medication Adherence; D011329:Prisoners; D011379:Prognosis; D013030:Spain; D019966:Substance-Related Disorders; D011795:Surveys and Questionnaires; D016896:Treatment Outcome