title: [Pathology background of targeted therapy; quality control in pathology].
abstract: The administration of targeted therapy of gastric carcinoma is a very important recent improvement of its treatment and prognosis. The basis of the successful treatment is the excellent quality of pathology, now including HER2 testing: the use of validated methods and strict criteria. This is especially important if we consider that many gastric cancers are diagnosed in small biopsy material, in which HER2 testing is challenging. This requires standardized, validated methods and experienced pathologists. Being of diagnostic and predictive significance, high quality of both the technique and the interpretation of the test is mandatory. In order to achieve general high quality in this field, technical and interpretation external quality control of HER2 testing is necessary. Hungarian pathologists with the help of Roche Hungary Ltd. completed an external quality control round which showed that most of the participating laboratories are able. Kulka J, Szirtes I, Szász AM, Kupcsulik P, Kenessey I, Lotz G, Tímár J. Pathology background of targeted therapy; quality control in pathology.
authors.affiliation: Semmelweis Egyetem II. sz. Patológiai Intézet 1091 Budapest Üllői út 93. kj@korb2.sote.hu
authors.forename: Janina
authors.initials: J
authors.lastname: Kulka
authors.forename: Ildikó
authors.initials: I
authors.lastname: Szirtes
authors.forename: A Marcell
authors.initials: AM
authors.lastname: Szász
authors.forename: Péter
authors.initials: P
authors.lastname: Kupcsulik
authors.forename: István
authors.initials: I
authors.lastname: Kenessey
authors.forename: Gábor
authors.initials: G
authors.lastname: Lotz
authors.forename: József
authors.initials: J
authors.lastname: Tímár
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D006814:Hungary; D058990:Molecular Targeted Therapy / Q000592:standards; D010336:Pathology / Q000592:standards*; D011786:Quality Control; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D013274:Stomach Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases