title: Selective central nervous system tropism of primary central nervous system lymphoma.
abstract: Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSLforthe CNS and its vasculature.
authors.affiliation: Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA
authors.forename: Liuyan
authors.initials: L
authors.lastname: Jiang
authors.forename: Laura A
authors.initials: LA
authors.lastname: Marlow
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Cooper
authors.forename: Christina V
authors.initials: CV
authors.lastname: Roemeling
authors.forename: David M
authors.initials: DM
authors.lastname: Menke
authors.forename: John A
authors.initials: JA
authors.lastname: Copland
authors.forename: Han W
authors.initials: HW
authors.lastname: Tun
mesh_terms: D000328:Adult; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D001921:Brain / Q000098:blood supply / Q000473:pathology; D001932:Brain Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D016543:Central Nervous System Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D053495:Osteopontin / Q000378:metabolism; D014183:Transplantation, Heterologous
chemical_list: D014408:Biomarkers, Tumor; D053495:Osteopontin