title: Reality distortion is related to the structure of the salience network in schizophrenia.
abstract: BACKGROUND
  An intrinsic cerebral network comprising the anterior cingulate and anterior insula (the salience network) is considered to play an important role in salience detection in healthy volunteers. Aberrant salience has been proposed as an important mechanism in the production of psychotic symptoms such as delusions and hallucinations (reality distortion). We investigated whether structural deficits in the salience network are associated with the reality distortion seen in schizophrenia.
  
  
  METHODS
  A sample of 57 patients in a clinically stable state of schizophrenia and 41 controls were studied with high-resolution magnetic resonance imaging.
  
  
  RESULTS
  Bilateral volume reduction was seen in the anterior cingulate and anterior insula in patients with schizophrenia. Reduced volume in the two left-sided regions of the salience network was significantly correlated with the severity of reality distortion.
  
  
  CONCLUSIONS
  These findings suggest that a deficit of grey matter in the salience network leads to an impaired attribution of salience to stimuli that is associated with delusions and hallucinations in schizophrenia.
authors.affiliation: Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen's Medical Centre, Nottingham, UK. Lena.Palaniyappan@nottingham.ac.uk
authors.forename: L
authors.initials: L
authors.lastname: Palaniyappan
authors.forename: P
authors.initials: P
authors.lastname: Mallikarjun
authors.forename: V
authors.initials: V
authors.lastname: Joseph
authors.forename: T P
authors.initials: TP
authors.lastname: White
authors.forename: P F
authors.initials: PF
authors.lastname: Liddle
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology