title: Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-α and IFN-α levels.
abstract: Glycyrrhiza species possess preventive and therapeutic potentials against various cancers. In the present study, we have evaluated regulation of apoptotic cell death by aqueous extracts of leaf and flower of an endemic Glycyrrhiza species; Glycyrrhiza flavescens subsp. antalyensis, in mouse melanoma cell lines. Both leaf and flower extracts induced apoptosis in terms of induction of caspase-3 activity, TNF-α and IFN-γ release. Concentrations of both TNF-α and IFN-γ in extract-treated groups were significantly and dose dependently exalted as compared to their relative controls. The effects of extracts on caspase-3, TNF-α and IFN-γ processes mediate the plausible mechanism of apoptosis induction of G. flavescens subsp. antalyensis.
authors.affiliation: Department of Biology, Faculty of Arts and Sciences, Akdeniz University, Antalya, Turkey. esra072000@yahoo.com
authors.forename: Esra Arslan
authors.initials: EA
authors.lastname: Aydemir
authors.forename: Ece Simsek
authors.initials: ES
authors.lastname: Oz
authors.forename: Ramazan Süleyman
authors.initials: RS
authors.lastname: Göktürk
authors.forename: Gülcan
authors.initials: G
authors.lastname: Ozkan
authors.forename: Kayahan
authors.initials: K
authors.lastname: Fiskin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006035:Glycyrrhiza / Q000737:chemistry*; D016898:Interferon-alpha / Q000378:metabolism*; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D016898:Interferon-alpha; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha