title: Two new resveratrol tetramers isolated from Cayratia japonica (Thunb.) Gagn. with strong inhibitory activity on fatty acid synthase and antioxidant activity.
abstract: Two new resveratrol tetramers, cajyphenol A (1) and cajyphenol B (2), together with two known resveratrol dimers, quadrangularin A (3) and pallidol (4), and resveratrol (5) were isolated from the stems of Cayratia japonica (Thunb.) Gagn. Their structures were established by means of NMR (¹H,¹H-COSY, ¹H, ¹³C-HSQC, HMBC, and NOESY) and ESI-MS analyses. Compounds 1-5 showed fast-binding inhibitory activities on fatty acid synthase with the IC₅₀ values of 1.63±0.02, 1.49±0.03, 7.50±0.01, 11.1±0.01, and 10.2±0.01 μM, respectively. Compounds 1-5 also exhibited antioxidant activities in the ORAC assay.
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing, P R China.
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Ma
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Song
authors.forename: Manyuan
authors.initials: M
authors.lastname: Wang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007192:Indenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012118:Resorcinols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000077185:Resveratrol; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D027844:Vitaceae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D007192:Indenes; D012118:Resorcinols; D013267:Stilbenes; C557095:cajyphenol A; C557096:cajyphenol B; D064429:Fatty Acid Synthases; D000077185:Resveratrol