title: Involvement of Glutamate transporter-1 in neuroprotection against global brain ischemia-reperfusion injury induced by postconditioning in rats.
abstract: Ischemic postconditioning refers to several transient reperfusion and ischemia cycles after an ischemic event and before a long duration of reperfusion. The procedure produces neuroprotective effects. The mechanisms underlying these neuroprotective effects are poorly understood. In this study, we found that most neurons in the CA1 region died after 10 minutes of ischemia and is followed by 72 hours of reperfusion. However, brain ischemic postconditioning (six cycles of 10 s/10 s reperfusion/re-occlusion) significantly reduced neuronal death. Significant up-regulation of Glutamate transporter-1 was found after 3, 6, 24, 72 hours of reperfusion. The present study showed that ischemic postconditioning decreases cell death and that upregulation of GLT-1 expression may play an important role on this effect.
authors.affiliation: Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; E-Mails: zhang951154@sina.com (W.Z.); 553909021@qq.com (Y.M.); kingwww629@126.com (B.W.); 13958354209@139.com (Q.L.).
authors.forename: Weiqiao
authors.initials: W
authors.lastname: Zhang
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Miao
authors.forename: Sanquan
authors.initials: S
authors.lastname: Zhou
authors.forename: Baofeng
authors.initials: B
authors.lastname: Wang
authors.forename: Qizhong
authors.initials: Q
authors.lastname: Luo
authors.forename: Yongming
authors.initials: Y
authors.lastname: Qiu
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D016923:Cell Death; D027342:Excitatory Amino Acid Transporter 2 / Q000235:genetics / Q000378:metabolism*; D057775:Ischemic Postconditioning; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism* / Q000628:therapy
chemical_list: D027342:Excitatory Amino Acid Transporter 2; C493395:Slc1a2 protein, rat