title: A fatal case of AIDS-defining meningoencephalitis by C. neoformans, sensitive to antifungal therapy.
abstract: Cryptococcus neoformans is the most common cause of life threatening meningoencephalitis in HIV-infected patients. Diagnosis is based on tests for cryptoccocal antigen in serum and cerebrospinal fluid, and on culture of the organism. We present a case of AIDS-related cryptococcal meningoencephalitis unresponsive to antifungal combination therapy, despite of evidence of fungal susceptibility in vitro. Significant decreases in cryptococcal antigen titers in serum and cerebrospinal fluid did not correlate with progress in disease and fatal outcome.
authors.affiliation: Clinic for Immunology and Rheumatology, Medical University of Hanover, Carl-Neuberg Str. 1, 30625 Hanover, Germany. Mohammad-Khani.Somayeh@mh-hannover.de
authors.forename: S
authors.initials: S
authors.lastname: Mohammad-Khani
authors.forename: B
authors.initials: B
authors.lastname: Otremba
authors.forename: R
authors.initials: R
authors.lastname: Klein
authors.forename: H H
authors.initials: HH
authors.lastname: Capelle
authors.forename: F
authors.initials: F
authors.lastname: Logemann
authors.forename: F C
authors.initials: FC
authors.lastname: Bange
authors.forename: R E
authors.initials: RE
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Stoll
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000134:cerebrospinal fluid / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents