title: [The changes of neurotransmitter content in spinal cord after exercise-induced central fatigue].
abstract: OBJECTIVE
  To investigate the changes of neurotransmitter concentration in spinal cord after exercise-induced central fatigue and study the mechanism of central fatigue at spinal level.
  
  
  METHODS
  Establish exercise-induced central fatigue model according to Bedford incremental loading training. The rats were divided into three groups, control group (C), immediately after training group (IT), rest 3 hours after training group (RT). Then using high performance liquid chromatography (HPLC) to detect the concentration of neurotransmitter in spinal cord.
  
  
  RESULTS
  Amino acid neurotransmitters in spinal cord increased in IT group: Glu, GABA increased significantly (P < 0.05), Gly also increased but have no statistic difference; while in RT group, amino acid neurotransmitters got back to normal. However monoamine neurotransmitters NE, 5-HT tended to decrease in IT group. In RT group 5-HT decreased dramatically (P < 0.05).
  
  
  CONCLUSIONS
  Exercise-induced fatigue changed the concentration of neurotransmitter in spinal cord.The results suggested that neurotransmitter in spinal cord might have relationship with exercise-induced fatigue, especially 5-HT might have more important effect on recovery of fatigue.
authors.affiliation: Institute of Healthy and Environmental Medicine, Academy of Military Medical Sciences, TianJin 300050, China.
authors.forename: Chuan-Xiang
authors.initials: CX
authors.lastname: Xu
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D005221:Fatigue / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000378:metabolism*; D009435:Synaptic Transmission
chemical_list: D018377:Neurotransmitter Agents