title: Blood levels of inflammatory and destructive biomarkers in coronary atherosclerosis of different severity.
abstract: In male patients with coronary atherosclerosis without acute coronary syndrome, the levels of inflammatory-destructive biomarkers of atherosclerotic plaque instability depended on the severity and dissemination of coronary atherosclerosis. The highest levels of C-reactive protein and matrix metalloproteinase 3 were found in men with atherosclerotic involvement of all three main coronary arteries, primarily their middle and distal segments, and in men with predominance of low-grade stenoses (<50%) of coronary arteries in areas of atherosclerotic plaques.
authors.affiliation: E. N. Meshalkin Research Institute of Circulatory Pathology, Federal Agency for High-Technological Medical Care, Novosibirsk, Russia. ragino@mail.ru
authors.forename: Yu I
authors.initials: YI
authors.lastname: Ragino
authors.forename: A M
authors.initials: AM
authors.lastname: Chernjavski
authors.forename: Ya V
authors.initials: YV
authors.lastname: Polonskaja
authors.forename: S Yu
authors.initials: SY
authors.lastname: Tchimbal
authors.forename: D A
authors.initials: DA
authors.lastname: Redjkin
authors.forename: E V
authors.initials: EV
authors.lastname: Semaeva
authors.forename: E V
authors.initials: EV
authors.lastname: Kashtanova
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood*; D023921:Coronary Stenosis / Q000097:blood*; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000473:pathology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D019278:Matrix Metalloproteinase 3