title: [Effects of melatonin on anti-oxidative function of lung injury induced by lipopolysaccharide in rats and ICAM-1 expression].
abstract: OBJECTIVE
  To investigate the protective effect of melatonin (MT) on lung tissues during acute lung injury (ALI) in rats and its possible mechanism.
  
  
  METHODS
  All rats were randomly divided into four groups: control group, lipopolysaccharide (LPS) group, dexamethasone (DEX) and MT treatment group. Myeloperoxidase (MPO) activity, superoxide dismutase (SOD) activity and malonaldehyde (MDA) content of lung tissues were detected at 3, 6 and 12 h after intratracheal instillation in each group. In addition, the expression of intercellular adhesion molecule-1 (ICAM-1) were observed through immunohistochemistry staining in lung tissues.
  
  
  RESULTS
  Compared with control group, SOD activity decreased significantly in LPS group (P < 0.01), but MPO activity,MDA content and the expression of ICAM-1 increased obviously (P < 0.01). The administration of MT and DEX mitigated above changes significantly (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  MT possessed protective effect on lung tissues during ALI through scavenging free radicals and inhibiting the expression of ICAM-1 probably.
authors.affiliation: Department of Pathophysiology, The School of Basic Medical Science, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Jun-yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Chun-hua
authors.initials: CH
authors.lastname: Ding
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Suo
authors.forename: Cai-feng
authors.initials: CF
authors.lastname: Dong
authors.forename: Yi-ling
authors.initials: YL
authors.lastname: Ling
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism*; D008070:Lipopolysaccharides; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009195:Peroxidase / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D008070:Lipopolysaccharides; D020011:Protective Agents; D018799:Intercellular Adhesion Molecule-1; D009195:Peroxidase; D013482:Superoxide Dismutase; D008550:Melatonin