title: Activation of AMP deaminase and adenosine deaminase in the liver during ammonia poisoning and hepatitis.
abstract: We studied the effect of acute ammonia poisoning and CCl4-induced subacute hepatitis on activities of AMP deaminase and adenosine deaminase in rat liver. Both models of liver failure were accompanied by an increase in activities of AMP deaminase and adenosine deaminase in the cytoplasmic fraction of the liver (by 2.4-4.2 times compared to the control). A direct correlation was found between activities of AMP deaminase and adenosine deaminase. We believe that two parallel pathways of AMP degradation are activated simultaneously, which leads to rapid depletion of adenylate reserves under pathological conditions.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Kosenko
authors.forename: Yu G
authors.initials: YG
authors.lastname: Kaminsky
mesh_terms: D000659:AMP Deaminase / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000641:Ammonia / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D006505:Hepatitis / Q000201:enzymology* / Q000209:etiology; D022124:Hyperammonemia / Q000139:chemically induced / Q000201:enzymology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000641:Ammonia; D002251:Carbon Tetrachloride; D000243:Adenosine Deaminase; D000659:AMP Deaminase