title: Rationale for reduced pressure reaming when stabilizing actual or impending pathological femoral fractures: a review of the literature.
abstract: Surgical treatment for impending or actual pathologic femoral fractures due to metastatic carcinoma has been shown to improve pain and quality of life. Surgery usually involves manipulation of the intramedullary (IM) portion of the femur to provide adequate stability and to restore function. IM nailing is generally considered the preferred treatment over plate osteosynthesis for most areas of the femur due to load sharing capabilities. Several reports have shown a high incidence of oxygen desaturation, hypotension, fat or air embolism, and mortality in the surgical treatment of femoral metastatic disease. The patient with a metastatic lesion in the femur is at risk for cardiopulmonary complications associated with entering the IM canal. Complications and mortality reported in the literature are varied. Benefits of IM nailing of femoral lesions and associated complications in the literature are discussed. The theoretical benefit of aspiration and irrigation while reaming is also reviewed. Reaming while irrigating under negative pressure provided through suction may potentially minimize cardiopulmonary and oncologic complications.
authors.affiliation: Orthopaedic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA. leddyl@musc.edu
authors.forename: Lee R
authors.initials: LR
authors.lastname: Leddy
mesh_terms: D000818:Animals; D003646:Debridement / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D005264:Femoral Fractures / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005266:Femoral Neoplasms / Q000150:complications / Q000556:secondary; D005594:Fracture Fixation, Intramedullary / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D006801:Humans; D011312:Pressure; D012307:Risk Factors; D012756:Sheep; D016019:Survival Analysis; D007507:Therapeutic Irrigation / Q000009:adverse effects / Q000295:instrumentation; D016896:Treatment Outcome