title: Long-term effect of toltrazuril on growth performances of dairy heifers and beef calves exposed to natural Eimeria zuernii and Eimeria bovis infections.
abstract: The long-term effects of a toltrazuril treatment against natural Eimeria bovis and/or Eimeria zuernii infections were investigated in comparison with diclazuril and untreated controls on two dairy (Italian Friesian breed) and two beef (Chianina breed) farms. At each trial site, 30 calves were allocated into three groups of 10 calves each: T (treated with toltrazuril), D (treated with diclazuril) and C (left untreated). For 40 weeks post-treatment, the calves were weighed and examined clinically and parasitologically. The oocyst counts as well as the number of scour days were significantly lower in the T group than in the D and C groups. Final bodyweights and body condition scores of the T group exceeded those of groups C and D. The results confirmed that toltrazuril was highly efficacious, safe and provided productive benefits in dairy and beef calves.
authors.affiliation: Department of Biopathological Science and Hygiene of Animal and Food Productions, University of Perugia, 4 San Costanzo Street, Postal Box 06126, Perugia, Italy.
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Veronesi
authors.affiliation: Department of Biopathological Science and Hygiene of Animal and Food Productions, University of Perugia, 4 San Costanzo Street, Postal Box 06126, Perugia, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Diaferia
authors.affiliation: Department of Biopathological Science and Hygiene of Animal and Food Productions, University of Perugia, 4 San Costanzo Street, Postal Box 06126, Perugia, Italy.
authors.forename: Orfeo
authors.initials: O
authors.lastname: Viola
authors.affiliation: Department of Biopathological Science and Hygiene of Animal and Food Productions, University of Perugia, 4 San Costanzo Street, Postal Box 06126, Perugia, Italy. Electronic address: daniela.piergilifioretti@unipg.it.
authors.forename: Daniela Piergili
authors.initials: DP
authors.lastname: Fioretti
mesh_terms: D000818:Animals; D002417:Cattle / Q000254:growth & development; D002418:Cattle Diseases / Q000188:drug therapy*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule / Q000662:veterinary; D004539:Eimeria / Q000302:isolation & purification*; D005243:Feces / Q000469:parasitology; D006128:Growth / Q000187:drug effects*; D016014:Linear Models; D009570:Nitriles / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D003049:Coccidiostats; D009570:Nitriles; D014227:Triazines; C057884:diclazuril; C036670:toltrazuril