title: Okicamelliaside, an extraordinarily potent anti-degranulation glucoside isolated from leaves of Camellia japonica.
abstract: Guided by anti-degranulation assays, we isolated from leaves of Camellia japonica an ellagic acid glucoside named okicamelliaside. The structure was elucidated as 3,4-dioxoloellagic acid 4'-O-β-D-glucopyranoside by spectroscopic and chemical methods. Okicamelliaside was 12,000 times more potent than the antihistaminic drug, ketotifen fumarate, in inhibiting the degranulation of RBL-2H3 cells.
authors.affiliation: Tropical Technology Center, Core Laboratory, Okinawa Health Biotechnology Research Development Center, Uruma, Okinawa, Japan. kenichi@subtropics.or.jp
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Onodera
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsuha
authors.forename: Mina
authors.initials: M
authors.lastname: Yasumoto-Hirose
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Tsuha
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hanashiro
authors.forename: Hideo
authors.initials: H
authors.lastname: Naoki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yasumoto
mesh_terms: D000818:Animals; D028244:Camellia / Q000737:chemistry*; D015550:Cell Degranulation / Q000187:drug effects*; D045744:Cell Line, Tumor; D004610:Ellagic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats
chemical_list: D005960:Glucosides; C556914:okicamelliaside; D004610:Ellagic Acid