title: Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection.
abstract: The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. In this review, I shall attempt to discuss current knowledge about the role of IL-19 on macrophages and the potential role in inflammatory bowel disease.
authors.affiliation: Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Izumisano, Osaka 598-8531, Japan. azuma@vet.osakafu-u.ac.jp
authors.forename: Yasu-Taka
authors.initials: YT
authors.lastname: Azuma
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Nakajima
authors.forename: George D
authors.initials: GD
authors.lastname: Yancopoulos
authors.forename: David M
authors.initials: DM
authors.lastname: Valenzuela
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Murphy
authors.forename: Margaret
authors.initials: M
authors.lastname: Karow
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003106:Colon / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D007378:Interleukins / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology / Q000503:physiopathology
chemical_list: C421250:IL19 protein, human; D007155:Immunologic Factors; D007378:Interleukins