title: Short term dietary fish oil supplementation improves motor deficiencies related to reserpine-induced parkinsonism in rats.
abstract: Fish oil (FO) supplementation could cause an increase in the concentration of plasmatic free fatty acids and, consequently, could compete with pro-inflammatory arachidonic acid (ARA) derived from brain biomembranes metabolism in the cerebrospinal fluid. Essential fatty acids (EFA) (n-3) have been reported by their antioxidant and neuroprotective properties, and therefore the influence of the FO supplementation on the reserpine-induced motor disorders was studied. Wistar rats were orally treated with FO solution for 5 days, and co-treated with reserpine (R; 1 mg/kg/mL) or its vehicle for 3 days (every other day). Reserpine-induced orofacial dyskinesia and catalepsy (P < 0.05) were prevented by FO (P < 0.05). Biochemical evaluations showed that reserpine treatment increased the lipid peroxidation in the cortex and striatum (P < 0.05), while the FO supplementation prevented this oxidative effect in both brain regions (P < 0.05). Our results showed the protective role of FO in the brain lipid membranes, reinforcing the beneficial effect of n-3 fatty acids in the prevention of degenerative and motor disorders.
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS 97105-900, Brazil.
authors.forename: Raquel Cristine Silva
authors.initials: RC
authors.lastname: Barcelos
authors.forename: Dalila Moter
authors.initials: DM
authors.lastname: Benvegnú
authors.forename: Nardeli
authors.initials: N
authors.lastname: Boufleur
authors.forename: Camila
authors.initials: C
authors.lastname: Pase
authors.forename: Angélica Martelli
authors.initials: AM
authors.lastname: Teixeira
authors.forename: Patrícia
authors.initials: P
authors.lastname: Reckziegel
authors.forename: Tatiana
authors.initials: T
authors.lastname: Emanuelli
authors.forename: João Batista T
authors.initials: JB
authors.lastname: da Rocha
authors.forename: Marilise Escobar
authors.initials: ME
authors.lastname: Bürger
mesh_terms: D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000517:prevention & control*; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000633:toxicity
chemical_list: D005395:Fish Oils; D020011:Protective Agents; D012110:Reserpine