title: Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging.
abstract: Positron emission tomography (PET) using [F-18]2-fluoro-2-deoxyglucose (FDG) fused with CT ((18)F-FDG PET/CT) has been widely adopted in oncological imaging. However, it is known that benign lesions and other metabolically active tissues, such as brown adipose tissue (BAT), can accumulate (18)F-FDG, potentially resulting in false-positive interpretation. Previous studies have reported that (18)F-FDG uptake in BAT is more common in children than in adults. We illustrate BAT FDG uptake in various anatomical locations in children and adolescents. We also review what is known about the effects of patient-related physical attributes and environmental temperatures on BAT FDG uptake, and discuss methods used to reduce BAT FDG uptake on (18)F-FDG PET.
authors.affiliation: Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada.
authors.forename: Terence S
authors.initials: TS
authors.lastname: Hong
authors.forename: Amer
authors.initials: A
authors.lastname: Shammas
authors.forename: Martin
authors.initials: M
authors.lastname: Charron
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Zukotynski
authors.forename: Laura A
authors.initials: LA
authors.lastname: Drubach
authors.forename: Ruth
authors.initials: R
authors.lastname: Lim
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging / Q000378:metabolism*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D007223:Infant; D008297:Male; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013382:Subtraction Technique; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18