title: Emerging therapeutic approaches in the management of retinal angiogenesis and edema.
abstract: Conditions resulting in retinal angiogenesis and edema (exudative age-related macular degeneration, diabetic retinopathy, retinal vein occlusion and retinopathy of prematurity) are major causes of visual impairment, with significant impact on quality of life. There has been increasing clinical usage of anti-vascular endothelial growth factor (anti-VEGF) agents to stop retinal angiogenesis and resolve intraretinal fluid arising from these conditions. However, anti-VEGFs have not been completely successful in curing these conditions, and a range of emerging treatments aimed at supplementing or competing with anti-VEGF agents are being developed. We will discuss the proposed merits these emerging agents bring to the treatment arsenal and how they compare with anti-VEGFs with regards to therapeutic activity, potency, specificity and safety. This review will also highlight recent pre-clinical research findings and suggest where future research might be directed.
authors.affiliation: Centre for Vascular Research, University of New South Wales, 3rd floor, Lowy Cancer Research Centre, Sydney, NSW 2052, Australia.
authors.forename: An
authors.initials: A
authors.lastname: Truong
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.forename: Levon M
authors.initials: LM
authors.lastname: Khachigian
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000150:complications* / Q000188:drug therapy*; D012160:Retina / Q000187:drug effects / Q000473:pathology; D012171:Retinal Vessels / Q000187:drug effects / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D042461:Vascular Endothelial Growth Factor A