title: Polymorphism of clotting factors in Hungarian patients with Raynaud's phenomenon.
abstract: Patients with primary Raynaud's phenomenon may have a genetically determined risk for clotting factors that predispose them to aberrant microvascular thrombosis. We investigated the prevalence of factor V substitution of G to A at position 1691 (FVLeiden), prothrombin G20210A, and methyltetrahydrofolate reductase C677T mutations in these patients. Two hundred (158 women, 42 men, mean age of 42.4 ± 13.7 years) consecutive patients with primary Raynaud's phenomenon and 200 age-sex-matched healthy controls of Hungarian origin were included in a case-control study. The prevalence of methyltetrahydrofolate reductase C677T homozygous among patients was significantly lower than in the control group (odds ratio 0.4, 95% confidence interval 0.2-0.9, P < 0.05). The prevalence of other thrombosis-associated alleles did not differ between patients with primary Raynaud's phenomenon and control subjects. FVLeiden, prothrombin G20210A, and polymorphism, prothrombin G20210A mutations have no apparent effect on the etiology of primary Raynaud's phenomenon.
authors.affiliation: Central Laboratory, Erzsébet Hospital, Sátoraljaújhely, Hungary.
authors.forename: Amir-Houshang
authors.initials: AH
authors.lastname: Shemirani
authors.forename: Edit
authors.initials: E
authors.lastname: Szomják
authors.forename: Emese
authors.initials: E
authors.lastname: Balogh
authors.forename: Csilla
authors.initials: C
authors.lastname: András
authors.forename: Dóra
authors.initials: D
authors.lastname: Kovács
authors.forename: Judit
authors.initials: J
authors.lastname: Acs
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Csiki
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*; D011928:Raynaud Disease / Q000453:epidemiology / Q000235:genetics*; D013927:Thrombosis / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)