title: Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform.
abstract: There is no technology available to support failing lung function for patients outside the hospital. An implantable lung assist device would augment lung function as a bridge to transplant or possible destination therapy. Utilizing biomimetic design principles, a microfluidic vascular network was developed for blood inflow from the pulmonary artery and blood return to the left atrium. Computational fluid dynamics analysis was used to optimize blood flow within the vascular network. A micro milled variable depth mold with 3D features was created to achieve both physiologic blood flow and shear stress. Gas exchange occurs across a thin silicone membrane between the vascular network and adjacent alveolar chamber with flowing oxygen. The device had a surface area of 23.1 cm(2) and respiratory membrane thickness of 8.7 ± 1.2 μm. Carbon dioxide transfer within the device was 156 ml min(-1) m(-2) and the oxygen transfer was 34 ml min(-1) m(-2). A lung assist device based on tissue engineering architecture achieves gas exchange comparable to hollow fiber oxygenators yet does so while maintaining physiologic blood flow. This device may be scaled up to create an implantable ambulatory lung assist device.
authors.affiliation: Center for Regenerative Medicine, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Hoganson
authors.forename: Howard I
authors.initials: HI
authors.lastname: Pryor
authors.forename: Erik K
authors.initials: EK
authors.lastname: Bassett
authors.forename: Ira D
authors.initials: ID
authors.lastname: Spool
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Vacanti
mesh_terms: D000818:Animals; D040761:Biomimetic Materials; D001775:Blood Circulation; D002245:Carbon Dioxide; D002417:Cattle; D003198:Computer Simulation; D006801:Humans; D008168:Lung / Q000098:blood supply*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008955:Models, Cardiovascular; D010100:Oxygen; D011474:Prosthesis Design; D011659:Pulmonary Gas Exchange / Q000502:physiology; D054457:Tissue Scaffolds
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen