title: Managing acute and chronic pancreatitis.
abstract: Pancreatitis may be acute or chronic. Although both can be caused by similar aetiologies, they tend to follow distinct natural histories. Around 80% of acute pancreatitis (AP) diagnoses occur secondary to gallstone disease and alcohol misuse. AP is commonly associated with sudden onset of upper abdominal pain radiating to the back that is usually severe enough to warrant the patient seeking urgent medical attention. Onset of pain may be related to a recent alcohol binge or rich, fatty meal. The patient may appear unwell, be tachycardic and have exquisite tenderness in the upper abdomen. Overall, 10-25% of AP episodes are classified as severe, leading to an associated mortality rate of 7.5%. Disease severity is best predicted from a number of clinical scoring systems which can be applied at diagnosis in association with repeated clinical assessment, measurement of acute inflammatory markers, and CT. All patients with suspected AP should be referred urgently. Chronic pancreatitis (CP) follows continued, repetitive or sustained injury to the pancreas and 70% of diagnoses occur secondary to alcohol abuse. The characteristic presenting feature of CP is insidious progression of chronic, severe, upper abdominal pain, radiating to the back, caused by a combination of progressive pancreatic destruction, inflammation and duct obstruction. Signs and symptoms include weight loss and steatorrhoea and later on diabetes. CP patients may also present with recurrent episodes mimicking AP, both symptomatically and metabolically. Diagnosis of CP should be based on symptom profile, imaging and assessment of exocrine and endocrine pancreatic function. CT should be the first-line imaging investigation.
authors.affiliation: Department of Surgery & Interventional Science, UCL.
authors.forename: James R A
authors.initials: JR
authors.lastname: Skipworth
authors.forename: Arjun
authors.initials: A
authors.lastname: Shankar
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Pereira
mesh_terms: D000208:Acute Disease; D005260:Female; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000175:diagnosis / Q000628:therapy*; D050500:Pancreatitis, Chronic / Q000175:diagnosis / Q000628:therapy; D012017:Referral and Consultation