title: Association of IL-1 polymorphisms and IL-1 serum levels with susceptibility to nasopharyngeal carcinoma.
abstract: Previous studies demonstrated that the polymorphism of interleukin-1 (IL-1) produce alterations of the protein expression and may contribute to oncogenetic processes. The aim of this study was to investigate the relationship between IL-1A gene polymorphisms and NPC susceptibility and the influence of on IL-1α serum levels in cases versus controls. To test whether the genetic variants of IL-1A gene modify the risk of nasopharyngeal carcinoma (NPC), we compared the -889C/T and rs3783553 polymorphisms between 248 patients with NPC and 296 healthy controls using polymerase chain reaction-restriction fragment length polymorphism. Serum IL-1α levels were measured by enzyme-linked immunosorbent assay. The rs3783553 (TTCA insertion or deletion) polymorphism of the IL-1A gene was significantly associated with the susceptibility to NPC. The variant homozygote genotype +/+ was associated with a significantly reduced risk of NPC as compared with the wild homozygote -/- genotype, and the serum IL-1α levels were significantly lower in individuals with homozygous +/+ genotypes. No association was found between the -889C/T polymorphisms and risk of NPC, and no statistically significant differences were found between rs3783553 polymorphism and clinical pathology indices. The IL-1A rs3783553 polymorphism might contribute to a risk of developing NPC by affecting the serum IL-1α secretion in the Chinese population.
authors.affiliation: Department of Pathology, Luzhou Medical College, Luzhou, Sichuan, People's Republic of China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Yang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Dai
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Qing-Xi
authors.initials: QX
authors.lastname: Guo
authors.forename: Shi-Ning
authors.initials: SN
authors.lastname: Li
mesh_terms: D002277:Carcinoma; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D012307:Risk Factors
chemical_list: D007375:Interleukin-1