title: γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs.
authors.affiliation: Medicinal Chemistry, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium. doehlric@ITS.JNJ.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Oehlrich
authors.forename: Didier J-C
authors.initials: DJ
authors.lastname: Berthelot
authors.forename: Harrie J M
authors.initials: HJ
authors.lastname: Gijsen
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000201:enzymology; D000577:Amides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000096:biosynthesis; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000577:Amides; D016229:Amyloid beta-Peptides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002934:Cinnamates; D036145:Ginsenosides; D007527:Isoenzymes; D053829:Amyloid Precursor Protein Secretases