title: Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC).
abstract: We retrospectively reviewed acute toxicity with cetuximab and radiotherapy, comparing it with a matched cisplatin group. The cetuximab group experienced significantly more toxicity--grade ≥3 oral mucositis (p=0.014), skin dermatitis (p=0.0004), ≥10% weight loss (p=0.03), and enteral feeding requirement (p=0.05). This finding of enhanced toxicity is similar to recent publications.
authors.affiliation: Department of Radiation Oncology, St. Luke's Hospital, Dublin, Ireland.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Walsh
authors.forename: Charles
authors.initials: C
authors.lastname: Gillham
authors.forename: Mary
authors.initials: M
authors.lastname: Dunne
authors.forename: Ian
authors.initials: I
authors.lastname: Fraser
authors.forename: Donal
authors.initials: D
authors.lastname: Hollywood
authors.forename: John
authors.initials: J
authors.lastname: Armstrong
authors.forename: Pierre
authors.initials: P
authors.lastname: Thirion
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002277:Carcinoma / Q000188:drug therapy / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell; D000068818:Cetuximab; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D010349:Patient Compliance; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068818:Cetuximab; D002945:Cisplatin