title: [Clinical guidelines for the diagnosis and treatment of dermatitis herpetiformis].
abstract: Dermatitis herpetiformis is an autoimmune blistering disease that appears as a cutaneous manifestation of gluten intolerance. It is one of a group of disorders that have gluten sensitivity in common, including celiac disease and gluten ataxia. Patients with dermatitis herpetiformis present with a pruritic papulovesicular rash on extensor surfaces and on the buttocks. Immunological studies demonstrate the presence of specific immunoglobulin (Ig) A anti-endomysial and anti-transglutaminase antibodies. The finding of granular deposits of IgA along the dermal-epidermal junction is pathognomonic of dermatitis herpetiformis. Treatment of dermatitis herpetiformis is based on a life-long, strict gluten-free diet, which improves all clinical aspects of gluten sensitivity, and dapsone, a drug that is only effective for the skin manifestations.
authors.affiliation: Departamento de Dermatología, Hospital del Mar, Parc de Salut Mar, Institut Municipal d'Investigació Mèdica, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain. jherrero@hospitaldelmar.org
authors.forename: J E
authors.initials: JE
authors.lastname: Herrero-González
mesh_terms: D003874:Dermatitis Herpetiformis / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D017410:Practice Guidelines as Topic