title: [Apigenin affects semen parameters in male mice].
abstract: OBJECTIVE
  To explore the effect of apigenin on semen parameters in male mice.
  
  
  METHODS
  Totally 100 healthy male mice of Kunming strain were randomly divided into 5 groups according to the body weight: negative control, solvent control, low-dose apigenin, median-dose apigenin and high-dose apigenin, the latter three groups given intragastric apigenin at a fixed time every day for 7 and 14 days. At 35 days after the first medication, all the mice were killed and detected for the sperm motion parameters by computer aided sperm analysis (CASA).
  
  
  RESULTS
  There were no statistically significant differences in sperm motion parameters, density and motility between the negative control and the three apigenin groups after 7-day medication. At 14 days, the high-dose apigenin group showed remarkable decreases in average path velocity (VAP), straight line velocity (VSL), straightness (STR), wobbliness (WOB), the percentage of grade b sperm and sperm motility, and a significant increase in beat cross frequency (BCF) as compared with the negative control group (P < 0.05).
  
  
  CONCLUSIONS
  Apigenin affects sperm motility in male mice to a certain extent.
authors.affiliation: Maternal and Child Health Service of Chengguan District, Lanzhou, Gansu 730030, China.
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Shi
authors.forename: Shu-yu
authors.initials: SY
authors.lastname: Liu
authors.forename: Ya
authors.initials: Y
authors.lastname: Chen
authors.forename: Fu-lun
authors.initials: FL
authors.lastname: Li
authors.forename: Hong-li
authors.initials: HL
authors.lastname: Xue
authors.forename: Yu-hui
authors.initials: YH
authors.lastname: Dang
authors.forename: Zhi-lan
authors.initials: ZL
authors.lastname: Li
mesh_terms: D000818:Animals; D047310:Apigenin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012661:Semen / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D047310:Apigenin