title: [Role of substance P in pressor response of nucleus ventromedialis to glutamate].
abstract: OBJECTIVE
  To analyze mechanism underlying pressor response of the nucleus ventromedialis (NVM) to glutamate.
  
  
  METHODS
  Effects of different drugs delivered by intra-brain or i.v. injections on blood pressure and heart rate were observed in rats.
  
  
  RESULTS
  (1) Excitation of the NVM by L-glutamate (Glu), injection of substance P (SP) into the nucleus dorsomedialis (NDM), nucleus paraventricularis (NPV) or rostral ventrolateral medulla (RVL), all induced pressor responses. (2) NVM pressor responses could be attenuated by preinjection of [D-Pro2, D-Phe7, D-Trp9]-SP (DPDPDT, a substance P antagonist) bilaterally into the NDM, NPV or RVL, but preinjection of atropine into the RVL had no such effect. (3) Phentolamine (i.v. ) also reduced the NVM pressor response, but propranolol or methyl atropine (i.v.) had no significant effect.
  
  
  CONCLUSIONS
  The NVM SPergic neurons can activate NDM SPergic neurons, which proceed to excite the NPV pressor area (SP receptor) and RVL (SP receptor)-sympathetic vasoconstrictor nerve system, thereby induce pressor response. The cardiac sympathetic and cardiac vagal nerves are not involved in this response.
authors.affiliation: Department of Physiology, Beijing Medical University, Bejing 100083.
authors.forename: J S
authors.initials: JS
authors.lastname: Wu
authors.forename: X
authors.initials: X
authors.lastname: Ding
authors.forename: Y H
authors.initials: YH
authors.lastname: Gu
authors.forename: Y G
authors.initials: YG
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Tan
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D018698:Glutamic Acid / Q000494:pharmacology*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology*
chemical_list: D017470:Receptors, Glutamate; D013373:Substance P; D018698:Glutamic Acid