title: [Association of abnormal lipid metabolism with INSIG2 gene variant in overweight and obese children].
abstract: OBJECTIVE
  To study the relationship between insulin induced gene 2 (INSIG2) variant and obesity or lipid metabolism in Chinese children and adolescents.
  
  
  METHODS
  A total number of 2030 school students at the age from 7 to 18 years were selected in Beijing. Physical indicators, serum lipids and the rs13428113 polymorphism in INSIG2 gene were examined for all the subjects.
  
  
  RESULTS
  The overall mutation rate of the rs13428113 polymorphism (T > C) was 49.3%. The differences of genotype and allele frequencies were not statistically significant among normal-weight, overweight and obesity groups (P > 0.05). Among the overweight students, those with CC genotype had higher body mass index, waist-hip ratio, bronchial triceps skin-fold, and anterior superior iliac spine skin-fold than TT/TC carriers. Among the obese group, those with CC genotype had higher total cholesterol level than TT/TC carriers (P < 0.05).
  
  
  CONCLUSIONS
  The rs13428113 polymorphism in INSIG2 gene was associated with abnormal lipid metabolism in overweight and obese children, which increasing the degree of obesity and abnormal serum lipids.
authors.affiliation: Division of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Hai-jun
authors.initials: HJ
authors.lastname: Wang
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D050177:Overweight / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins