title: Pharmacokinetics of polymyxin B in an infant with multidrug-resistant Klebsiella pneumoniae bacteremia.
abstract: We report our experience with a 9-month-old infant treated with intravenous polymyxin B for multidrug-resistant Klebsiella pneumoniae bacteremia. Serial blood samples were obtained at steady state and serum drug concentrations were determined using a validated liquid chromatography-mass spectrometry method. The elimination half-lives of polymyxin B1 and isoleucine-polymyxin B1 were found to be 3.1 and 4.7 hours, respectively.
authors.affiliation: Division of Pediatric Infectious Diseases, Weill-Cornell Medical College, New York, NY, USA. chs2032@med.cornell.edu
authors.forename: Christine M
authors.initials: CM
authors.lastname: Salvatore
authors.forename: Kamilia
authors.initials: K
authors.lastname: Abdelraouf
authors.forename: Deyin D
authors.initials: DD
authors.lastname: Hsing
authors.forename: Vincent H
authors.initials: VH
authors.lastname: Tam
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D002853:Chromatography, Liquid; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D013058:Mass Spectrometry; D011112:Polymyxin B / Q000008:administration & dosage / Q000493:pharmacokinetics*; D044967:Serum / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D011112:Polymyxin B