title: Angiogenic activity of sera from interstitial lung disease patients in relation to pulmonary function.
abstract: OBJECTIVE
  Chronic inflammation and fibrosis are characteristic of interstitial lung diseases (ILD) and are accompanied by neovascularisation. The aim of this study was to examine the relationship between the angiogenic activity of sera from ILD patients and pulmonary function tests.
  
  
  METHODS
  Serum samples were obtained from 225 ILD patients: 83 with sarcoidosis, 31 with idiopathic pulmonary fibrosis, 29 with extrinsic allergic alveolitis, 16 with collagen vascular diseases, 13 with scleroderma with pulmonary manifestations (SCL), 14 with Wegener's granulomatosis (WG), 12 with silicosis, 12 with pulmonary Langerhans cells histiocytosis, 10 with drug-induced pulmonary fibrosis, 5 with cryptogenic organizing pneumonia, and 36 healthy volunteers. An animal model of leukocyte induced angiogenesis assay was used as an angiogenic test. In all patients spirometry, whole body plethysmography, static lung compliance, and single breath diffusing capacity of the lungs for carbon monoxide (DLco) were performed.
  
  
  RESULTS
  The angiogenic properties of sera from ILD differed, depending on the disease. In the examined ILD, the most important functional disturbances were decreases in static compliance and DLco. The correlation between DLco and angiogenic activity of sera was observed (P<0.05).
  
  
  CONCLUSIONS
  The data show that sera from ILD patients constitute a source of mediators modulating angiogenesis. Angiogenic activity of sera of ILD patients is related to DLco.
authors.affiliation: Department of Family Medicine, Warsaw Medical University, Warsaw, Poland. tmzielonka@wp.pl
authors.forename: Tadeusz M
authors.initials: TM
authors.lastname: Zielonka
authors.forename: U
authors.initials: U
authors.lastname: Demkow
authors.forename: E
authors.initials: E
authors.lastname: Radzikowska
authors.forename: B
authors.initials: B
authors.lastname: Bialas
authors.forename: M
authors.initials: M
authors.lastname: Filewska
authors.forename: K
authors.initials: K
authors.lastname: Zycinska
authors.forename: M H
authors.initials: MH
authors.lastname: Obrowski
authors.forename: J
authors.initials: J
authors.lastname: Kowalski
authors.forename: K A
authors.initials: KA
authors.lastname: Wardyn
authors.forename: E
authors.initials: E
authors.lastname: Skopinska-Rozewska
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D042461:Vascular Endothelial Growth Factor A