title: Hemostimulating effects of immobilized hyaluronidase and their mechanisms during cytostatic-induced myelosuppression.
abstract: We studied the effect of immobilized hyaluronidase on hemopoiesis under conditions of cyclophosphamide-induced suppression. The preparation was shown to possess high hemostimulating activity. The stimulatory effect of hyaluronidase on the erithron was more pronounced than its effect on the granulocytic hemopoietic stem due to increase in functional activity of hemopoietic precursors and hemopoiesis-inducing microenvironment.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: A V
authors.initials: AV
authors.lastname: Artamonov
authors.forename: A A
authors.initials: AA
authors.lastname: Bekarev
authors.forename: E I
authors.initials: EI
authors.lastname: Vereschagin
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskiy
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D004800:Enzymes, Immobilized / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA
chemical_list: D004800:Enzymes, Immobilized; D003520:Cyclophosphamide; D006821:Hyaluronoglucosaminidase