title: Characterization of nitric oxide delivery systems produced by various nanotechnologies.
abstract: Advanced formulations having the capability of long-term protection and preserving the integrity of the nitric oxide molecule were developed for the efficient delivery of nitric oxide. The methods for the production and delivery of nitric oxide produced from diethylenetriamine diazeniumdiolate or S-nitrosoglutathione as a nitric oxide donor to desired target sites in a controlled and sustained release manner are described. The pharmacological assessments of advanced formulations using in vitro and in vivo tests are also described in detail. These systems can be used for the treatment of cardiovascular diseases and sexual dysfunctions.
authors.affiliation: School of Pharmacy, University of Missouri, Kansas City, MO, USA. leech@umkc.edu
authors.forename: Chi H
authors.initials: CH
authors.lastname: Lee
mesh_terms: D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008567:Membranes, Artificial; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry; D009569:Nitric Oxide / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D009569:Nitric Oxide; D019344:Lactic Acid