title: [Progress in metabolic engineering of microbial production of 1,3-dihydroxyacetone].
abstract: 1,3-Dihydroxyacetone is widely used in cosmetics, medicines and food products. We reviewed the recent progress in metabolic pathways, key enzymes, as well as metabolic engineering for microbial production of 1,3-dihydroxyacetone. We addressed the research trend to increase yield of 1,3-dihydroxyacetone by improving the activity of glycerol dehydrogenase with genetic engineering, and regulating of fermentation process based on metabolic characteristic of the strain.
authors.affiliation: Institute of Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Sun
authors.forename: Zhongce
authors.initials: Z
authors.lastname: Hu
authors.forename: Yuguo
authors.initials: Y
authors.lastname: Zheng
authors.forename: Yinchu
authors.initials: Y
authors.lastname: Shen
mesh_terms: D004098:Dihydroxyacetone / Q000096:biosynthesis*; D005285:Fermentation; D005818:Genetic Engineering / Q000379:methods*; D020600:Gluconobacter oxydans / Q000235:genetics* / Q000378:metabolism; D007218:Industrial Microbiology / Q000379:methods; D060847:Metabolic Engineering / Q000379:methods*; D013401:Sugar Alcohol Dehydrogenases / Q000378:metabolism
chemical_list: D013401:Sugar Alcohol Dehydrogenases; C020672:glycerol dehydrogenase; D004098:Dihydroxyacetone