title: [Determination of cyanuric acid in milk and milk powder by high performance liquid chromatography-tandem mass spectrometry].
abstract: A method for the determination of cyanuric acid (CYA) in milk and milk powder was developed using high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI MS/MS). The target analyte was extracted from samples by acetonitrile, and the proteins were precipitated at the same time. The supernatant was cleaned up and enriched with a strong anion exchange column, analysed by HPLC-MS/MS with an AX column, and quantified by internal standard method. Good linearity was obtained in the range of 50-2000 microg/L. The recoveries were all ranged from 97% to 121% at three levels, 200, 500 and 1000 microg/kg, and the relative standard deviations (RSDs) were all below 4.8%. Limit of quantification (LOQ) was 200 microg/kg. The method has high accuracy and precision, the operation is fast, easy and suitable for the determination of CYA in milk and milk powder.
authors.affiliation: Animal, Plant and Food Inspection Center of Jiangsu Entry-Exit Inspection and Quarantine Bureau, Nanjing 210001, China. wendy_gqw@yahoo.com.cn
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Gui
authors.forename: Han
authors.initials: H
authors.lastname: Liu
authors.forename: Zengyun
authors.initials: Z
authors.lastname: Zhao
authors.forename: Tao
authors.initials: T
authors.lastname: Ding
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Xu
authors.forename: Weijian
authors.initials: W
authors.lastname: Shen
authors.forename: Chongyu
authors.initials: C
authors.lastname: Shen
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005506:Food Contamination / Q000032:analysis; D008892:Milk / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014227:Triazines / Q000032:analysis*
chemical_list: D014227:Triazines; C004632:cyanuric acid