title: [The effect of Gynostemma pentaphyllum (GP) on plasma lipoprotein metabolism and lipoperoxidation lipoprotein in the experimental hyperglycemia rats].
abstract: OBJECTIVE
  To study the regulation mechanism of GP on plasma lipoprotein metabolism and To explore its mechanism of anti-lipoperoxidation in the experimental hyperglycemia rats.
  
  
  METHODS
  The rats were raised with high fat diet for six weeks,and the model of hyperglycemia was then established. After that, those rats were treated with high or low dose of GP and xuezhikang as a masculine comparison for four weeks. Then, those rat were executed, and detected the plasma TC, TG, LDL-C, HDL-C, GSH-Px, at the same time the SOD, CAT and MDA concentration also be mensurated.
  
  
  RESULTS
  The results showed that high and low dose of GP could decrease the concentration of serum LDL-C, cholesterol and triglyceride remarkably and raise the concentration of HDL-C. The activity of GSH-Px, SOD and CAT in GP groups were promoted and the level of MDA was decreased distinctly.
  
  
  CONCLUSIONS
  The GP can therapy the abnormity of serum lipid and has obviously anti-lipoperoxidation affection.
authors.affiliation: Sports Department of Hunan University of Science and Technology, Xiangtan 411201.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Xu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Shi
authors.forename: Chi-Pin
authors.initials: CP
authors.lastname: Liu
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D029774:Gynostemma; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism*; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids; D008075:Lipoproteins, HDL; D010936:Plant Extracts; D014280:Triglycerides; C474918:gypenoside; D002784:Cholesterol