title: Decoy receptor 3 expression in esophageal squamous cell carcinoma: correlation with tumour invasion and metastasis.
abstract: OBJECTIVE
  Decoy receptor 3 (DcR3) is a soluble receptor, which can bind to and inactivate the apoptosis-inducing ligands. We studied a possible association between DcR3 expression and clinicopathologic features in patients with esophageal squamous cell carcinoma (ESCC).
  
  
  METHODS
  The mRNA expression of DcR3 was examined by RT-PCR in 109 primary ESCC patients. For the 52 pairs of DcR3 positive tissues, the protein expression was determined by immunohistochemistry.
  
  
  RESULTS
  There was a strong correlation among DcR3 mRNA expression and tumor invasion (P=0.01) and lymph node metastasis (P=0.036). We also found that there was a correlation between DcR3 overexpression with lymph node metastasis (P=0.014) in 52 pairs of DCR3 mRNA positive tissues.
  
  
  CONCLUSIONS
  Our finding suggested that the overexpression of DcR3 is significantly related with ESCC clinical staging. DcR3 might be a candidate as a tumor specific biomarker for ESCC.
authors.affiliation: Department of Thoracic and Cardiac Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xiong
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Ge
authors.forename: Xueqing
authors.initials: X
authors.lastname: Xu
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Yang
authors.forename: Kang
authors.initials: K
authors.lastname: Yang
authors.forename: Yaoguang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yun
authors.initials: Y
authors.lastname: Bai
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007150:Immunohistochemistry; D008137:Longitudinal Studies; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012995:Solubility
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D053323:Receptors, Tumor Necrosis Factor, Member 6b