title: Gene polymorphisms involved in triptans pharmacokinetics and pharmacodynamics in migraine therapy.
abstract: BACKGROUND
  Migraine is a debilitating and painful neurological disorder affecting millions of people worldwide and often worsened by chronification. Triptans represent a powerful pharmacological resource in migraine management; nevertheless, a significant portion of treated patients do not obtain consistent pain relief through triptans. Pharmacogenomics may offer a new way to rationalise triptans administration, based on characterisation of the individual genomic profile.
  
  
  METHODS
  The review summarises the results of association studies between polymorphisms in genes involved in the kinetics and dynamics of triptans, and clinical response to them in migraineurs.
  
  
  RESULTS
  A summary of data available at present from genetic studies in the field of triptan therapy in migraine, and a picture of the difficulties facing research into the pharmacogenomics of triptans.
  
  
  CONCLUSIONS
  Pharmacogenomic studies of triptans suggest that some genetic determinants influence drug response, but the complexity of the field calls for application of a systematic approach to genetic association studies, allowing identification of a therapy response prediction panel with adequate predictive power.
authors.affiliation: Sapienza University, 2nd School of Medicine, Advanced Molecular Diagnostic Unit, Department of Biochemical Sciences, Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Gentile
authors.forename: Marina
authors.initials: M
authors.lastname: Borro
authors.forename: Maurizio
authors.initials: M
authors.lastname: Simmaco
authors.forename: Serena
authors.initials: S
authors.lastname: Missori
authors.forename: Noemi
authors.initials: N
authors.lastname: Lala
authors.forename: Paolo
authors.initials: P
authors.lastname: Martelletti
mesh_terms: D002986:Clinical Trials as Topic; D056726:Genetic Association Studies; D015894:Genome, Human; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000235:genetics*; D008995:Monoamine Oxidase / Q000235:genetics / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000235:genetics; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D014363:Tryptamines / Q000493:pharmacokinetics* / Q000627:therapeutic use*
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D014363:Tryptamines; D008995:Monoamine Oxidase