title: Stachylines A-D from the sponge-derived fungus Stachylidium sp.
abstract: The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of E/Z-isomers.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.
authors.forename: Celso
authors.initials: C
authors.lastname: Almeida
authors.forename: Natalja
authors.initials: N
authors.lastname: Part
authors.forename: Sarah
authors.initials: S
authors.lastname: Bouhired
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000382:microbiology; D013237:Stereoisomerism; D014443:Tyrosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C558039:stachyline A; D014443:Tyrosine