title: [Experimental studies of Panax notoginseng saponins and Ginkgo biloba extracts on preventing acute oxygen toxicity].
abstract: OBJECTIVE
  To investigate the preventive effects of Panax notoginseng saponins (PNS) and Ginkgo biloba extracts (GbE) on acute oxygen toxicity and the possible mechanisms.
  
  
  METHODS
  Mice were injected intraperitoneally with PNS and GbE for 5 days, then were exposed to 500 kPa hyperbaric oxygen (HBO) for 60 min, the convulsion latency, times and interval were observed. Moreover, reactive oxygen (RO) unit, MDA, NO, GSH levels and GSH-Px, CAT, MAO activities of mice brain were determined after they were exposed to HBO for 15 min.
  
  
  RESULTS
  PNS and GbE could markedly prolong the convulsion latency and interval, reduce convulsion times, decrease contents of MDA and NO in mice brain, keep RO unit, GSH and GSH-Px at higher levels, but had no effects on CAT and MAO activities.
  
  
  CONCLUSIONS
  PNS and GbE could effectively prevent acute oxygen toxicity, which were related to their antioxidant activities.
authors.affiliation: Department of Nautical Medicine, Faculty of Navy Medicine, Second Military Medical University of PLA, Shanghai 200433, China.
authors.forename: Run-ping
authors.initials: RP
authors.lastname: Li
authors.forename: Yong-bing
authors.initials: YB
authors.lastname: Cao
authors.forename: Han-ming
authors.initials: HM
authors.lastname: Zhang
authors.forename: Heng-yi
authors.initials: HY
authors.lastname: Tao
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Xiong-fei
authors.initials: XF
authors.lastname: Xu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004242:Diving / Q000009:adverse effects; D020441:Ginkgo biloba; D006931:Hyperbaric Oxygenation / Q000009:adverse effects; D008297:Male; D051379:Mice; D010100:Oxygen / Q000506:poisoning*; D053723:Panax notoginseng; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D012503:Saponins; D010100:Oxygen