title: Serum paraoxonase and arylesterase activities in patients with lacunar infarction: a case control study.
abstract: OBJECTIVE
  The aim of this study was to assess paraoxonase (PON1) and arylesterase (ARE) activities and polymorphism in patients with lacunar infarctions.
  
  
  METHODS
  The PON1 activity, ARE and lipid profile were determined in 37 patients and 53 healthy individuals. Descriptive and inferential statistics were used to analyze the data.
  
  
  RESULTS
  A total of 37 patients (20 males and 17 females) were studied. The levels of PON1 activity in patients and healthy individuals were 63.5±46.7IU/L and 95.5±75.5IU/L, respectively (p=0.024). The same values for ARE were 54.3±19.3KU/L for patients and 69.1±29.3KU/L for controls (p=0.008). Polymorphism in Q192R location shows statistically different presentation in patient group compared to healthy controls with an odds ratio of 3.42 (CI 95%: 1.24-9.44, p=0.017).
  
  
  CONCLUSIONS
  According to this study, we suggest that PON1 192R polymorphism may play a minor role as a risk marker for developing lacunar infarctions in a group of Iranian population.
authors.affiliation: Neurology Department, Zahedan University of Medical Sciences, Zahedan, Iran. amoghtaderi@gmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Moghtaderi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.forename: Soroosh
authors.initials: S
authors.lastname: Dabiri
authors.forename: Abdolkarim
authors.initials: A
authors.lastname: Moazeni-Roodi
authors.forename: Motahreh
authors.initials: M
authors.lastname: Hosseini
mesh_terms: D000483:Alleles; D043303:Aryldialkylphosphatase / Q000097:blood / Q000235:genetics*; D020520:Brain Infarction / Q000097:blood / Q000235:genetics*; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044967:Serum / Q000737:chemistry
chemical_list: D008055:Lipids; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human