title: RNA interference in the clinic: challenges and future directions.
abstract: Inherent difficulties with blocking many desirable targets using conventional approaches have prompted many to consider using RNA interference (RNAi) as a therapeutic approach. Although exploitation of RNAi has immense potential as a cancer therapeutic, many physiological obstacles stand in the way of successful and efficient delivery. This Review explores current challenges to the development of synthetic RNAi-based therapies and considers new approaches to circumvent biological barriers, to avoid intolerable side effects and to achieve controlled and sustained release.
authors.affiliation: U.T. M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Chad V
authors.initials: CV
authors.lastname: Pecot
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
authors.forename: Robert L
authors.initials: RL
authors.lastname: Coleman
authors.forename: Gabriel
authors.initials: G
authors.lastname: Lopez-Berestein
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D034622:RNA Interference / Q000502:physiology*