title: Clinical management of uterine papillary serous carcinoma.
abstract: Uterine papillary serous carcinoma (UPSC) is an aggressive variant of endometrial cancer. Owing to its rarity, most clinicians are unfamiliar with the clinical aspects and management of UPSC. Furthermore, little prospective evidence exists regarding how best to treat this subset of patients. In anticipation of prospective clinical trials, this article summarizes the latest results of various clinical management options in the different substages of UPSC, with a special focus on the effects of cytoreductive surgery, comprehensive surgical staging and different adjuvant treatment options in relation to recurrence rate and survival outcome.
authors.affiliation: Radboud University Nijmegen Medical Centre, 791 Department of Obstetrics and Gynecology, PO Box 9101, 6500 HB Nijmegen, The Netherlands. t.roelofsen@obgyn.umcn.nl
authors.forename: Thijs
authors.initials: T
authors.lastname: Roelofsen
authors.forename: Maaike A
authors.initials: MA
authors.lastname: van Ham
authors.forename: Joanne A
authors.initials: JA
authors.lastname: de Hullu
authors.forename: Leon F
authors.initials: LF
authors.lastname: Massuger
mesh_terms: D024221:Antineoplastic Protocols; D002291:Carcinoma, Papillary / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D018284:Cystadenocarcinoma, Serous / Q000628:therapy*; D005260:Female; D006801:Humans; D054539:Medication Therapy Management; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D015996:Survival Rate; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000628:therapy*