title: The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats.
abstract: The aim of this study was to evaluate the activities of anti-inflammatory and analgesic of the total flavonoids extraction from Oxytropis falcate Bunge (FEO) after transdermal administration. The pharmacokinetics and absolute bioavailability of FEO in rat, furthermore, was studied. Firstly, the anti-inflammatory and analgesic effects of the FEO were studied by xylene-induced ear edema, adjuvant-induced joint inflammation law in rats, acetic acid-induced writhing and hot-plate tests in mice. Secondly, we developed a sensitive and specific HPLC method to analyze 2', 4'-dihydroxychalcone (TFC, the mainly ingredient of FEO) in rat plasma to study the pharmacokinetic of TEC. The results showed FEO has anti-inflammatory and analgesic property in a dose-dependent manner, and that the high dose group (90.6 mg/kg) of FEO appeared more significantly effective than the positive drug. From the pharmacokinetic studies of TFC in rats, we got the main pharmacokinetic parameters of TFC, providing a basis for the future studies in clinic.
authors.affiliation: Department of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, PR China.
authors.forename: Zhi-peng
authors.initials: ZP
authors.lastname: Chen
authors.forename: Min-ming
authors.initials: MM
authors.lastname: Qu
authors.forename: Hong-xuan
authors.initials: HX
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Yan-yu
authors.initials: YY
authors.lastname: Xiao
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Tu-lin
authors.initials: TL
authors.lastname: Lu
authors.forename: Bao-chang
authors.initials: BC
authors.lastname: Cai
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001682:Biological Availability; D047188:Chalcones / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005419:Flavonoids / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use; D006358:Hot Temperature; D007249:Inflammation / Q000097:blood / Q000188:drug therapy; D007592:Joint Diseases / Q000097:blood / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D033021:Oxytropis / Q000737:chemistry*; D010146:Pain / Q000097:blood / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014992:Xylenes
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D047188:Chalcones; D005419:Flavonoids; D010936:Plant Extracts; D014992:Xylenes; C059354:2',4'-dihydroxychalcone; D019342:Acetic Acid