title: Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay.
abstract: We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge.
authors.affiliation: Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, Maryland 20852, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Castelán-Vega
authors.forename: Laura
authors.initials: L
authors.lastname: Corvette
authors.forename: Lev
authors.initials: L
authors.lastname: Sirota
authors.forename: Juan
authors.initials: J
authors.lastname: Arciniega
mesh_terms: D000818:Animals; D022122:Anthrax Vaccines / Q000276:immunology* / Q000528:radiation effects*; D000907:Antibodies, Bacterial / Q000097:blood; D000992:Antitoxins / Q000097:blood; D004355:Drug Stability; D006358:Hot Temperature; D051379:Mice; D009500:Neutralization Tests
chemical_list: D022122:Anthrax Vaccines; D000907:Antibodies, Bacterial; D000992:Antitoxins