title: [Therapeutic effects of left ventricular assist device on pump failure caused by acute myocardial infarction].
abstract: OBJECTIVE
  To evaluate the therapeutic effects of a left ventricular assist device (LVAD) on pump failure caused by acute myocardial infarction (AMI) in dogs.
  
  
  METHODS
  The pump failure caused by AMI was established in 18 dogs, 9 of them were treated with a LVAD that could expel the autoblood from the left ventricle into the aorta and named the experimental group, and the rest of them were treated with intravenous infusion and served as the control group. The changes of arrhythmia, mortality, pulmonary capillary wedge pressure (PCWP), left ventricular end-diastolic pressure (LVEDP), peripheral artery pressure and the diameter of left ventricular chamber were observed.
  
  
  RESULTS
  The ratio of ventricular extrasystole and the mortality resulted from ventricular fibrillation of the experimental group were lower than that of the control group. The systolic blood pressure of peripheral artery of the control group was significantly lower (< 100 mmHg) than that of the experimental group (>100 mmHg, P < 0.01). The PCWP and LVEDP of the experimental group during all the stages 45 minutes after the procedures were significantly lower than that of the control group (P < 0.01). The left ventricular end-diastolic diameter of the control group was larger than that of the experimental groups (P < 0.01).
  
  
  CONCLUSIONS
  To assist circulation by expelling autoblood from left ventricle into aorta in dogs with AMI could reduce the frequency of ventricular fibrillation, improve hemodynamics, and prevent the enlargement of left ventricle. Therefore, it could play an important role in assisting the left ventricular functions.
authors.affiliation: PLA General Hospital, Beijing 100853, China.
authors.forename: Dong-ya
authors.initials: DY
authors.lastname: Wang
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Li
authors.forename: De-xin
authors.initials: DX
authors.lastname: Liu
authors.forename: Rui-han
authors.initials: RH
authors.lastname: Chen
mesh_terms: D000818:Animals; D001243:Assisted Circulation / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D006353:Heart-Assist Devices; D006439:Hemodynamics; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*; D016277:Ventricular Function, Left