title: Lessons from anti-TNF biologics: infliximab failure in a TRAPS family with the T50M mutation in TNFRSF1A.
authors.affiliation: Centre for Diabetes, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Whitechapel, London E1 2AT, UK. b.nedjai@imperial.ac.uk
authors.forename: Belinda
authors.initials: B
authors.lastname: Nedjai
authors.forename: Niamh
authors.initials: N
authors.lastname: Quillinan
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Coughlan
authors.forename: Leigh
authors.initials: L
authors.lastname: Church
authors.forename: Michael F
authors.initials: MF
authors.lastname: McDermott
authors.forename: Graham A
authors.initials: GA
authors.lastname: Hitman
authors.forename: Mark D
authors.initials: MD
authors.lastname: Turner
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D000068800:Etanercept; D005190:Family; D005260:Female; D005334:Fever; D056660:Hereditary Autoinflammatory Diseases / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D000069285:Infliximab; D007494:Ireland; D008297:Male; D051379:Mice; D050505:Mutant Proteins / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D010375:Pedigree; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics*; D017211:Treatment Failure; D000079424:Tumor Necrosis Factor Inhibitors; D048069:Tumor Necrosis Factors / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D001688:Biological Products; D007074:Immunoglobulin G; D050505:Mutant Proteins; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D000079424:Tumor Necrosis Factor Inhibitors; D048069:Tumor Necrosis Factors; D000069285:Infliximab; D000068800:Etanercept