title: Alzheimer's Disease Drug Discovery--11th International Conference--Promising New Therapeutic Approaches. 27-28 September 2010, Jersey City, NJ, USA.
abstract: The 11th Alzheimer's Disease Drug Discovery International Conference, held in Jersey City, NJ, USA, included topics covering new therapeutic developments in the field of Alzheimer's disease. This conference report highlights selected presentations on the use of patient-specific stem cells, and neuroprotection, regeneration and cognitive enhancement strategies for the prevention or treatment of Alzheimer's disease. Investigational approaches discussed include allopregnanolone for neuron protection and regeneration, PDE5 inhibitors as therapeutics, upregulating the protein Klotho to prevent cognitive decline, targeting memory deficits induced by Aβ42 oligomers, inhibiting striatal-enriched protein tyrosine phosphatase (STEP) for treating neuropsychiatric disorders, and agonism of GABA-A receptors to treat age-related cognitive deficits.
authors.affiliation: Brigham & Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. mwolfe@rics.bwh.harvard.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Wolfe
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D003072:Cognition Disorders / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy; D055808:Drug Discovery; D058785:GABA-A Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D000090265:Klotho Proteins; D008569:Memory Disorders / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy; D058990:Molecular Targeted Therapy; D009416:Nerve Regeneration / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D033581:Stem Cell Transplantation / Q000639:trends
chemical_list: D058785:GABA-A Receptor Agonists; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D058986:Phosphodiesterase 5 Inhibitors; D005966:Glucuronidase; D000090265:Klotho Proteins