title: Hailey-Hailey disease treatment with Botulinum toxin type A.
abstract: Two sisters with recurrent lesions, one on axillae and other on the groin, and with limited response to classical treatments were treated with injections botulinum toxin type A. We observed marked improvement in the patient treated in the groin and complete remission in the patient treated in the axillae. It was possible to spare the use of systemic antibiotics and topical corticosteroids. The high cost is a restrictive factor to routine use and large studies are necessary to access efficacy and cost benefit profile.
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre, RS, Brasil.
authors.forename: Giancarlo Rezende
authors.initials: GR
authors.lastname: Bessa
authors.forename: Thaís Corsetti
authors.initials: TC
authors.lastname: Grazziotin
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Manzoni
authors.forename: Magda Blessmann
authors.initials: MB
authors.lastname: Weber
authors.forename: Renan Rangel
authors.initials: RR
authors.lastname: Bonamigo
mesh_terms: D000368:Aged; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D019274:Botulinum Toxins, Type A