title: Role of the antiangiogenic agent bevacizumab in the treatment of elderly patients with metastatic colorectal cancer.
abstract: Although major progress has been achieved in the treatment of metastatic colorectal cancer with the employment of biological antiangiogenic agents, several questions remain open for discussion regarding the use of this therapy in elderly patients with metastatic colorectal cancer. In Western countries, the total number of elderly patients with colorectal cancer is expected to increase in the future. As adverse physical or socioeconomic conditions are more common in the elderly, an assessment of the patient's suitability for this therapy should be performed before a treatment decision is made. Most patients in clinical trials of the antiangiogenic drug bevacizumab were aged <65 years and thus the efficacy and tolerability of this agent in older patients has been less well explored. However, this article shows that older and younger patients with metastatic colorectal cancer appeared to derive similar survival benefit from bevacizumab treatment. Elderly patients were also found to have significant prolongation of median progression-free survival with the addition of bevacizumab to their treatment, with a similar magnitude of improvement in this outcome being observed in younger and older patients. It should be emphasized that the patients included in the studies discussed in this article were eligible for clinical trials and therefore may not be representative of a more general elderly population. Careful selection of patients and monitoring of treatment effects are required to optimize use of the antiangiogenic agent bevacizumab in older patients.
authors.affiliation: Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. maria.dibartolomeo@istitutotumori.mi.it
authors.forename: Maria
authors.initials: M
authors.lastname: Di Bartolomeo
authors.forename: Filippo
authors.initials: F
authors.lastname: Pietrantonio
authors.forename: Antonia
authors.initials: A
authors.lastname: Martinetti
authors.forename: Roberto
authors.initials: R
authors.lastname: Buzzoni
authors.forename: Arpine
authors.initials: A
authors.lastname: Gevorgyan
authors.forename: Emilio
authors.initials: E
authors.lastname: Bajetta
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D018572:Disease-Free Survival; D006801:Humans
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab