title: Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance.
abstract: Obesity is a multifactor disease with a very complicated etiology. Genetic factors play an important role in the development of primary obesity. They may be responsible for up to 40% of causes leading to obesity. There are a great number of genes affecting food intake and energy expenditure. Serious consequences accompanying obesity, e.g., type 2 diabetes and lipid abnormalities may be caused by increased level of proinflammatory cytokines, such as IL-1, IL-6, and TNF. It is possible that polymorphisms located in cytokine genes affect the level of protein expression. It is known that IL-6 plays a role in lipid metabolism and energy expenditure. The polymorphism found in point 174 (G174C) of a promoter region of IL-6 gene affects the level of interleukin-6 expression and, consequently, may lead to obesity and correlated conditions.
authors.affiliation: Department of Laboratory Diagnostics, Warsaw Medical University, Warsaw, Poland. aksiak@interia.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Popko
authors.forename: E
authors.initials: E
authors.lastname: Gorska
authors.forename: U
authors.initials: U
authors.lastname: Demkow
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D004734:Energy Metabolism; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D019947:Receptors, Interleukin-6 / Q000502:physiology
chemical_list: D015850:Interleukin-6; D019947:Receptors, Interleukin-6