title: Structure of the liver in mice with transplanted Lewis carcinoma during polychemotherapy and correction with betulonic acid and its derivatives.
abstract: Morphological and morphometric studies of the liver with transplanted Lewis carcinoma were performed after polychemotherapy and correction with betulonic and [3-oxo-20(29)-lupene-28-oil]-3-aminopropionic acids and their methyl esters. It was demonstrated than betulonic and [3-oxo-20(29)-lupene-28-oil]-3-aminopropionic acids reduced the degree of degenerative changes and volume density of necrotic changes in hepatocytes after polychemotherapy. Methyl esters of these acids little changed the severity and spreading of destructive and necrotic changes in the liver caused by complex cytostatic therapy. It was also shown that all studied triterpenoids exhibited more pronounced antimetastatic effect (evaluated by the decrease in volume density of liver metastases) compared to polychemotherapy.
authors.affiliation: N. N. Vorozhtsov Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Zhukova
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashih
authors.forename: D E
authors.initials: DE
authors.lastname: Semenov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D018827:Carcinoma, Lewis Lung; D004359:Drug Therapy, Combination / Q000379:methods*; D022781:Hepatocytes / Q000187:drug effects* / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D011422:Propionates / Q000737:chemistry / Q000627:therapeutic use; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D009828:Oleanolic Acid; D011422:Propionates; C118308:betulonic acid; D000094062:Betulinic Acid