title: Sumatriptan as a treatment for cyclic vomiting syndrome: a clinical trial.
abstract: OBJECTIVE
  Cyclic vomiting syndrome (CVS) is associated with migraine. This study aimed to evaluate the efficacy of sumatriptan in treating CVS.
  
  
  METHODS
  Twelve patients were enrolled in this trial. Sumatriptan was administered either subcutaneously [(age x 4 + 20)/100 x 3 mg] or by nasal spray (NS; 20 mg). Response to the treatment was classified as complete, effective, or noneffective.
  
  
  RESULTS
  Eleven patients, who presented with 35 attacks, were treated by subcutaneous injection of sumatriptan. The treatment was responsive in 19 attacks. The efficacy of sumatriptan was high in attacks that occurred in cases with a family history of migraine compared to those without (p = .0482). Five patients were treated with sumatriptan NS for six attacks. The treatment was completely responsive in two of six attacks. We observed no adverse effects associated with sumatriptan treatment in this trial.
  
  
  CONCLUSIONS
  We conclude that sumatriptan has potential efficacy in treating of patients with CVS.
authors.affiliation: Department of Pediatrics, Teikyo University School of Medicine, Japan. t-hikita@ra2.so-net.ne.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hikita
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kodama
authors.forename: Sono
authors.initials: S
authors.lastname: Kaneko
authors.forename: Kaori
authors.initials: K
authors.lastname: Amakata
authors.forename: Kaori
authors.initials: K
authors.lastname: Ogita
authors.forename: Daishi
authors.initials: D
authors.lastname: Mochizuki
authors.forename: Fumiaya
authors.initials: F
authors.lastname: Kaga
authors.forename: Natsue
authors.initials: N
authors.lastname: Nakamoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujii
authors.forename: Akira
authors.initials: A
authors.lastname: Kikuchi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D018170:Sumatriptan / Q000627:therapeutic use*; D016896:Treatment Outcome; D014839:Vomiting / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D018170:Sumatriptan