title: The effect of HAART and calendar period on Kaposi's sarcoma and non-Hodgkin lymphoma: results of a match between an AIDS and cancer registry.
abstract: OBJECTIVE
  To assess the impact of HAART use on AIDS-defining Kaposi's sarcoma and non-Hodgkin lymphoma (NHL) among adults with AIDS.
  
  
  METHODS
  Registry linkage study.
  
  
  METHODS
  Adults diagnosed with AIDS from 1990 to 2000 in the San Francisco AIDS case registry were matched with cancer cases diagnosed from 1985 to 2002 in the California Cancer Registry. Multivariate Cox proportional hazard models were used to evaluate the risk and survival of AIDS-related Kaposi's sarcoma, systemic NHL, and primary central nervous system (CNS) lymphoma.
  
  
  RESULTS
  Of the 14 183 adults with AIDS, 3028 were diagnosed with Kaposi's sarcoma, 776 with systemic NHL, and 254 with CNS NHL. After adjustment for potential confounders, more recent calendar period and use of HAART were significantly associated with a decreased risk of Kaposi's sarcoma, whereas HAART use but not calendar period was significantly associated with systemic and CNS NHL. In adjusted analysis of Kaposi's sarcoma survival time, there was strong evidence of a reduced risk of death associated with HAART use and more recent calendar period. In contrast, in adjusted analyses of systemic NHL survival time, HAART use was not associated with improved survival time; however, calendar period was associated with longer survival. In adjusted analysis of CNS NHL survival time, only cancer treatment was associated with a longer survival time.
  
  
  CONCLUSIONS
  After controlling for calendar period and other confounders, use of HAART decreased the risk of Kaposi's sarcoma, systemic NHL, and CNS NHL. Use of HAART also increased Kaposi's sarcoma survival time but not NHL survival time.
authors.affiliation: San Francisco Department of Public Health, AIDS Office, USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Pipkin
authors.forename: Susan
authors.initials: S
authors.lastname: Scheer
authors.forename: Ijeoma
authors.initials: I
authors.lastname: Okeigwe
authors.forename: Sandra
authors.initials: S
authors.lastname: Schwarcz
authors.forename: David H
authors.initials: DH
authors.lastname: Harris
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Hessol
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012042:Registries; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult