title: [Pathogenetic concepts for pigment epithelial detachment in exudative AMD].
abstract: Retinal pigment epithelial detachment (PED) as a specific manifestation in exudative age-related macular degeneration (AMD) may lead to a substantial decrease of central vision. An understanding of important events during the development of PED is necessary for a successful therapeutic intervention. At present the leading pathogenetic theory is that of reduced hydraulic conductivity of Bruch's membrane. The mechanisms underlying this process are caused by increased deposition of lipids, enhanced collagen cross-linking and alteration in the ratio of tissue-dissolving enzymes and their inhibitors. The association of newly formed vessels and an unaltered RPE pump activity can lead to the clinical picture of serous PED during exudative AMD.
authors.affiliation: Ophtha-Lab, Hohenzollernring 74, Münster, Germany. susanne.wasmuth@makula-centrum-muenster.de
authors.forename: S
authors.initials: S
authors.lastname: Wasmuth
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000502:physiology; D001813:Blood-Retinal Barrier / Q000502:physiology; D016570:Bruch Membrane / Q000473:pathology / Q000503:physiopathology*; D002463:Cell Membrane Permeability / Q000502:physiology; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D057092:Geographic Atrophy / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008055:Lipids; D008268:Macular Degeneration / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology / Q000502:physiology; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000503:physiopathology; D012163:Retinal Detachment / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D015861:Retinal Neovascularization / Q000473:pathology / Q000503:physiopathology; D019717:Tissue Inhibitor of Metalloproteinase-3 / Q000378:metabolism; D057135:Wet Macular Degeneration / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*
chemical_list: D008055:Lipids; D019717:Tissue Inhibitor of Metalloproteinase-3