title: Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study.
abstract: OBJECTIVE
  To assess the association between serum triglyceride levels and cancer risk.
  
  
  METHODS
  The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio.
  
  
  RESULTS
  Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06-1.26) in men and 1.15 (1.05-1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers.
  
  
  CONCLUSIONS
  Data from our study provided evidence for a possible role of serum triglycerides in cancer development.
authors.affiliation: Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Austria.
authors.forename: Wegene
authors.initials: W
authors.lastname: Borena
authors.forename: Tanja
authors.initials: T
authors.lastname: Stocks
authors.forename: Håkan
authors.initials: H
authors.lastname: Jonsson
authors.forename: Susanne
authors.initials: S
authors.lastname: Strohmaier
authors.forename: Gabriele
authors.initials: G
authors.lastname: Nagel
authors.forename: Tone
authors.initials: T
authors.lastname: Bjørge
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Randi
authors.initials: R
authors.lastname: Selmer
authors.forename: Martin
authors.initials: M
authors.lastname: Almquist
authors.forename: Christel
authors.initials: C
authors.lastname: Häggström
authors.forename: Anders
authors.initials: A
authors.lastname: Engeland
authors.forename: Steinar
authors.initials: S
authors.lastname: Tretli
authors.forename: Hans
authors.initials: H
authors.lastname: Concin
authors.forename: Alexander
authors.initials: A
authors.lastname: Strasak
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Hanno
authors.initials: H
authors.lastname: Ulmer
mesh_terms: D000328:Adult; D000465:Algorithms; D015992:Body Mass Index; D003299:Cooperative Behavior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides