title: Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease.
abstract: Both phenotype and treatment response vary in patients with Parkinson's disease. Anatomical and functional imaging studies suggest that individual symptoms may represent malfunction of different segregated networks running in parallel through the basal ganglia. In this study, we use a newly described, electrophysiological method to describe cortico-subthalamic networks in humans. We performed combined magnetoencephalographic and subthalamic local field potential recordings in thirteen patients with Parkinson's disease at rest. Two spatially and spectrally separated networks were identified. A temporoparietal-brainstem network was coherent with the subthalamic nucleus in the alpha (7-13 Hz) band, whilst a predominantly frontal network was coherent in the beta (15-35 Hz) band. Dopaminergic medication modulated the resting beta network, by increasing beta coherence between the subthalamic region and prefrontal cortex. Subthalamic activity was predominantly led by activity in the cortex in both frequency bands. The cortical topography and frequencies involved in the alpha and beta networks suggest that these networks may be involved in attentional and executive, particularly motor planning, processes, respectively.
authors.affiliation: Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Litvak
authors.forename: Ashwani
authors.initials: A
authors.lastname: Jha
authors.forename: Alexandre
authors.initials: A
authors.lastname: Eusebio
authors.forename: Robert
authors.initials: R
authors.lastname: Oostenveld
authors.forename: Tom
authors.initials: T
authors.lastname: Foltynie
authors.forename: Patricia
authors.initials: P
authors.lastname: Limousin
authors.forename: Ludvic
authors.initials: L
authors.lastname: Zrinzo
authors.forename: Marwan I
authors.initials: MI
authors.lastname: Hariz
authors.forename: Karl
authors.initials: K
authors.lastname: Friston
authors.forename: Peter
authors.initials: P
authors.lastname: Brown
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D058256:Brain Waves / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D046690:Deep Brain Stimulation / Q000379:methods; D018491:Dopamine Agonists / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D012146:Rest; D020531:Subthalamic Nucleus / Q000503:physiopathology*
chemical_list: D018491:Dopamine Agonists