title: Histometric analysis of bone repair in bone-implant interface using a polylactic/polyglycolic acid copolymer associated with implants in rabbit tibia.
abstract: The purpose of this study was to evaluate the association of the combination of polylactic/polyglycolic acid around implants installed with and without primary stability through the histometric analysis of bone-implant interface. We used male rabbits, each of which received 2 titanium implants in each tibial metaphysis. The animals were divided into 4 groups: control with primary stability (CPS), control without primary stability (C), polymer with primary stability (PPS), and polymer without primary stability (P). Euthanasia was performed at postoperative days 40 and 90. The pieces were embedded in resin, sectioned, scraped, and stained with alizarin red and Stevenel blue. Histometric analysis evaluated the linear extension of contact between the bone and implant surface on the implant collar (CIC) and contact between the bone and implant surface on the first thread (CFT). Also evaluated was the area of newly formed bone (ANB) in the first thread. The results showed that there was new bone formation in all groups and during all periods. At 40 days, the ANB was higher in the PPS group than in the P group (P < .001); the CFT was statistically higher in the CPS group than the PPS group (P < .001) and was higher in the CPS group than the C group (P < .001). At 40 and 90 days, the CIC was higher in the P group than in the C group (P < .001). In conclusion, the copolymer had biocompatibility, enhanced bone healing, and presented osteoconductive properties, thus raising the contact between bone and implant, even without primary stability.
authors.affiliation: Department of Morphology, Piracicaba Dental School - UNICAMP, Piracicaba, São Paulo, Brazil. alefreire@fop.unicamp.br
authors.forename: Alexandre Rodrigues
authors.initials: AR
authors.lastname: Freire
authors.forename: Ana Cláudia
authors.initials: AC
authors.lastname: Rossi
authors.forename: Thallita Pereira
authors.initials: TP
authors.lastname: Queiroz
authors.forename: Jéssica Lemos
authors.initials: JL
authors.lastname: Gulinelli
authors.forename: Francisley Ávila
authors.initials: FÁ
authors.lastname: Souza
authors.forename: Rogério
authors.initials: R
authors.lastname: Margonar
authors.forename: Idelmo Rangel
authors.initials: IR
authors.lastname: Garcia-Júnior
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hochuli-Vieira
authors.forename: Roberta
authors.initials: R
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D015921:Dental Implants; D017268:Dental Prosthesis Retention; D019344:Lactic Acid / Q000737:chemistry / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008297:Male; D016348:Osseointegration / Q000187:drug effects* / Q000502:physiology; D011100:Polyglycolic Acid / Q000737:chemistry / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits; D013977:Tibia / Q000166:cytology / Q000187:drug effects / Q000601:surgery
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D015921:Dental Implants; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid