title: [Effects of NMDA and non-NMDA agonists on the respiratory rhythmical discharge of the hypoglossal nerve in the medullary slice from neonatal rats].
abstract: OBJECTIVE
  To study the possible role of the NMDA and non-NMDA receptor on the generation and modulation of basic respiratory rhythm.
  
  
  METHODS
  Experiments were performed on the medullary slices isolated from the neonatal rats. Respiratory rhythmical discharge activity (RRDA) of the hypoglossal nerve was recorded by suction electrode, then the effects of the excitatory amino acids and its antagonists on the RRDA were investigated by adding these drugs into the perfused modified Kreb's solution.
  
  
  RESULTS
  After applying the non-NMDA receptor agonist KA, it was found that the respiratory circle and the expiratory time were lightly lengthened, but the NMDA receptor agonist NMDA had no effect on the RRDA. Both of the mutual antagonist DNQX and AP-5 remarkably decreased the discharge frequency and the integral amplitude, accompanied by the shortening of the inspiratory time, DNQX simultaneously shortened the respiratory circle and the expiratory time.
  
  
  CONCLUSIONS
  During the generation and modulation of the mammalian respiratory rhythm, NMDA receptor may mainly play a role in the amplitude of the respiratory activity, the non-NMDA receptor can not only affect the amplitude of the respiratory discharge also modulate the frequency of the respiratory rhythm.
authors.affiliation: Department of Physiology, First Military Medical University, Guangzhou 510515, China.
authors.forename: B X
authors.initials: BX
authors.lastname: Pan
authors.forename: Z H
authors.initials: ZH
authors.lastname: Wu
authors.forename: S H
authors.initials: SH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D007002:Hypoglossal Nerve / Q000502:physiology; D008526:Medulla Oblongata / Q000502:physiology*; D016202:N-Methylaspartate / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012125:Respiratory Center / Q000502:physiology*
chemical_list: D016202:N-Methylaspartate