title: The influence of family history on prostate cancer risk: implications for clinical management.
abstract: • The most recent evidence for the link between a family history of prostate cancer and individual risk for future disease was examined, with the aim of understanding what the existence and nature of a family history of prostate cancer does to a man's risk of developing the disease. • Our findings highlighted the clear association between a family history of prostate cancer and increased risk of developing the disease; with a greater proximity of relatedness, greater number of family members affected and/or earlier age at diagnosis of the family member elevating risk further. • These findings have important clinical implications for the identification and subsequent management of men deemed to be at increased risk of developing prostate cancer. The evidence for prostate cancer risk reduction with the mono 5α-reductase inhibitor (5ARI) finasteride in a low-risk population and, more recently, with the dual 5ARI dutasteride in a population at increased risk of developing the disease, has potential to expand management options for men at risk of developing prostate cancer beyond more frequent and/or earlier surveillance. • Given that family history can be easily assessed in routine clinical practice, it should be regarded as an important parameter to consider alongside PSA level for prostate cancer risk assessment.
authors.affiliation: Department of Urology and Andrology, Danube Hospital, Vienna, AustriaDepartment of Urology, Hospital Clinic Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, SpainDivision of Surgery and Interventional Science, University College London (UCL) Hospitals NHS Foundation Trust/UCL Comprehensive Biomedical Research Centre, London, UKDepartment of Urology, Academic Hospital, Braunschweig, GermanyDepartment of Urology and Andrology, Hospital St. John of God, Vienna, AustriaDepartment of Urology, Erasmus Medical Center, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Sant'Andrea Hospital 2nd School of Medicine, 'La Sapienza' University of Rome, Rome, Italy.
authors.forename: Stephan
authors.initials: S
authors.lastname: Madersbacher
authors.affiliation: Department of Urology and Andrology, Danube Hospital, Vienna, AustriaDepartment of Urology, Hospital Clinic Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, SpainDivision of Surgery and Interventional Science, University College London (UCL) Hospitals NHS Foundation Trust/UCL Comprehensive Biomedical Research Centre, London, UKDepartment of Urology, Academic Hospital, Braunschweig, GermanyDepartment of Urology and Andrology, Hospital St. John of God, Vienna, AustriaDepartment of Urology, Erasmus Medical Center, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Sant'Andrea Hospital 2nd School of Medicine, 'La Sapienza' University of Rome, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Alcaraz
authors.affiliation: Department of Urology and Andrology, Danube Hospital, Vienna, AustriaDepartment of Urology, Hospital Clinic Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, SpainDivision of Surgery and Interventional Science, University College London (UCL) Hospitals NHS Foundation Trust/UCL Comprehensive Biomedical Research Centre, London, UKDepartment of Urology, Academic Hospital, Braunschweig, GermanyDepartment of Urology and Andrology, Hospital St. John of God, Vienna, AustriaDepartment of Urology, Erasmus Medical Center, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Sant'Andrea Hospital 2nd School of Medicine, 'La Sapienza' University of Rome, Rome, Italy.
authors.forename: Mark
authors.initials: M
authors.lastname: Emberton
authors.affiliation: Department of Urology and Andrology, Danube Hospital, Vienna, AustriaDepartment of Urology, Hospital Clinic Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, SpainDivision of Surgery and Interventional Science, University College London (UCL) Hospitals NHS Foundation Trust/UCL Comprehensive Biomedical Research Centre, London, UKDepartment of Urology, Academic Hospital, Braunschweig, GermanyDepartment of Urology and Andrology, Hospital St. John of God, Vienna, AustriaDepartment of Urology, Erasmus Medical Center, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Sant'Andrea Hospital 2nd School of Medicine, 'La Sapienza' University of Rome, Rome, Italy.
authors.forename: Peter
authors.initials: P
authors.lastname: Hammerer
authors.affiliation: Department of Urology and Andrology, Danube Hospital, Vienna, AustriaDepartment of Urology, Hospital Clinic Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, SpainDivision of Surgery and Interventional Science, University College London (UCL) Hospitals NHS Foundation Trust/UCL Comprehensive Biomedical Research Centre, London, UKDepartment of Urology, Academic Hospital, Braunschweig, GermanyDepartment of Urology and Andrology, Hospital St. John of God, Vienna, AustriaDepartment of Urology, Erasmus Medical Center, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Sant'Andrea Hospital 2nd School of Medicine, 'La Sapienza' University of Rome, Rome, Italy.
authors.forename: Anton
authors.initials: A
authors.lastname: Ponholzer
authors.affiliation: Department of Urology and Andrology, Danube Hospital, Vienna, AustriaDepartment of Urology, Hospital Clinic Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, SpainDivision of Surgery and Interventional Science, University College London (UCL) Hospitals NHS Foundation Trust/UCL Comprehensive Biomedical Research Centre, London, UKDepartment of Urology, Academic Hospital, Braunschweig, GermanyDepartment of Urology and Andrology, Hospital St. John of God, Vienna, AustriaDepartment of Urology, Erasmus Medical Center, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Sant'Andrea Hospital 2nd School of Medicine, 'La Sapienza' University of Rome, Rome, Italy.
authors.forename: Fritz H
authors.initials: FH
authors.lastname: Schröder
authors.affiliation: Department of Urology and Andrology, Danube Hospital, Vienna, AustriaDepartment of Urology, Hospital Clinic Department of Urology, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, SpainDivision of Surgery and Interventional Science, University College London (UCL) Hospitals NHS Foundation Trust/UCL Comprehensive Biomedical Research Centre, London, UKDepartment of Urology, Academic Hospital, Braunschweig, GermanyDepartment of Urology and Andrology, Hospital St. John of God, Vienna, AustriaDepartment of Urology, Erasmus Medical Center, University Medical Centre, Rotterdam, The NetherlandsDepartment of Urology, Sant'Andrea Hospital 2nd School of Medicine, 'La Sapienza' University of Rome, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tubaro
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D055088:Early Detection of Cancer / Q000379:methods*; D005192:Family Health; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D058891:5-alpha Reductase Inhibitors