title: [Effects of infrasound exposure on several enzymes activities of spleen and liver in rats].
abstract: OBJECTIVE
  To investigate the changes of several enzymes activities in the spleen and liver of rats after exposure to 8 Hz 130 dB infrasound for different time.
  
  
  METHODS
  Thirty-five male SD rats were randomly divided into five groups. Rats of group 1 served as control, rats from group 2 to 5 were exposed to 8 Hz 130 dB infrasound, 2 hours per day, for 1 wk, 2 wk, 3 wk, and 4 wk, respectively. The changes of enzymes activities in spleen and liver of rats were observed.
  
  
  RESULTS
  Monoamine oxidase activities in spleen were significantly increased at 1 wk and 2 wk, it was decreased at 3 wk, and increased again at 4 wk (P < 0.05). There were no changes in the liver compared with the control group. Glutathione peroxides activities in spleen were significantly increased at 4 wk (P < 0.05) and it also increased in liver at 1 wk (P < 0.05). Superoxide dismutase activities in spleen were increased significantly from 1 wk to 4 wk, but there were no markedly changes in liver. The level of malondialdehyde in spleen were increased at 3 wk and 4 wk. In the liver, it were increased at 1 wk and 2 wk, and decreased at 3 wk, but it increased again at 4 wk (P < 0.05).
  
  
  CONCLUSIONS
  The results indicated that lipid peroxidation and oxygen free radicals in spleen and liver were increased after infrasound exposure and it might induce the damage in tissue or cells.
authors.affiliation: Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710033, China.
authors.forename: Yao-ming
authors.initials: YM
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
authors.forename: Shuang-bin
authors.initials: SB
authors.lastname: Gao
authors.forename: Dong-hai
authors.initials: DH
authors.lastname: Zhu
authors.forename: Weng-jing
authors.initials: WJ
authors.lastname: Luo
authors.forename: Xiu-hong
authors.initials: XH
authors.lastname: Liu
authors.forename: Jing-yuan
authors.initials: JY
authors.lastname: Chen
authors.forename: Jing-zao
authors.initials: JZ
authors.lastname: Chen
mesh_terms: D000818:Animals; D004781:Environmental Exposure; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D009622:Noise; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D013154:Spleen / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase