title: [Determination of baicalin in Shuanghuanglian oral liquid on composite mercury film electrode based on chemical modified].
abstract: OBJECTIVE
  A novel Eu-PB composite mercury film electrode (GC/Eu-PB/MFE) based on chemical modified was developed for the determination of baicalin and the investigation of its the electrochemical behavior.
  
  
  METHODS
  Cyclic voltammetry and differential pulse voltammetry were used.
  
  
  RESULTS
  The adsorption characteristic of baicalin was observed in Britton-Robinson buffer solution (pH 6.0) at GC/Eu-PB/MFE. The reduction peak of baicalin was observed at -1.22 V (vs SCE) and peak current was linear to the baicalin from 8.0 x 10(-9) to 1.0 x 10(-6) mol x L(-1) (r = 0.9992, n=8). The limit of detection was 1.2 x 10(-9) mol x L(-1) (S/N = 3). The average recovery was 99.83%, with RSD of 2.3% (n=8). The baicalin in Shuanghuanglian oral can be directly determined without pretreatment.
  
  
  CONCLUSIONS
  The GC/Eu-PB/MFE was used to determine baicalin in Shuanghuanglian oral with good repeatability and high sensitivity. The method can be used for the quality control of Chinese traditional medicines containing Scutellaria baicalensis.
authors.affiliation: School of Pharmacy, Medical College of QingHai University, Xining 810001, China. yqsong1224@163.com
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Song
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiufang
authors.initials: X
authors.lastname: Hou
mesh_terms: D000327:Adsorption; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000032:analysis*; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D005419:Flavonoids / Q000032:analysis*; D008628:Mercury / Q000737:chemistry; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C038044:baicalin; D008628:Mercury