title: Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease.
abstract: OBJECTIVE
  Cerebral small vessel disease (SVD), including white matter lesions and lacunar infarcts, is related to gait disturbances. Microbleeds (MB) are another manifestation of SVD, but their clinical impact remains unclear. We therefore investigated the relation between the number and location of MB and gait, independently of white matter lesions and lacunar infarcts.
  
  
  METHODS
  MRI scanning was performed in 485 nondemented elderly individuals with cerebral SVD. The number and location of MB were rated. Gait was assessed with a GAITRite system and the Tinetti and Timed-Up-and-Go tests. MB were related to gait parameters by age, height, total brain volume, white matter lesions, and number of lacunar infarcts-adjusted linear regression.
  
  
  RESULTS
  A higher number of MB was independently related to a shorter stride length and poorer performance on the Tinetti and Timed-Up-and-Go tests. These relations seemed to be explained by MB in the temporal and frontal lobe and basal ganglia, including the thalamus.
  
  
  CONCLUSIONS
  This study offers the first indication that MB may be associated with gait disturbances, independently of other coexisting markers of SVD.
authors.affiliation: Department of Neurology, Radboud University, Nijmegen Medical Centre, 6500 HB Nijmegen, the Netherlands.
authors.forename: Karlijn F
authors.initials: KF
authors.lastname: de Laat
authors.forename: Heleen A C
authors.initials: HA
authors.lastname: van den Berg
authors.forename: Anouk G W
authors.initials: AG
authors.lastname: van Norden
authors.forename: Rob A R
authors.initials: RA
authors.lastname: Gons
authors.forename: Marcel G M
authors.initials: MG
authors.lastname: Olde Rikkert
authors.forename: Frank-Erik
authors.initials: FE
authors.lastname: de Leeuw
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D015331:Cohort Studies; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D055806:Microvessels / Q000503:physiopathology*; D008875:Middle Aged; D011446:Prospective Studies