title: [Cancer immunotherapy. Importance of overcoming immune suppression].
abstract: Increasing evidence indicates that the immune system is involved in the control of tumor progression. Effective antitumor immune response depends on the interaction between several components of the immune system, including antigen-presenting cells and different T cell subsets. However, tumor cells develop a number of mechanisms to escape recognition and elimination by the immune system. In this review we discuss these mechanisms and address possible therapeutic approaches to overcome the immune suppression generated by tumors.
authors.affiliation: Laboratorio de Terapia Génica, Facultad de Ciencias Biomédicas, Universidad Austral, Buenos Aires, Argentina.
authors.forename: Mariana
authors.initials: M
authors.lastname: Malvicini
authors.forename: Guillermo
authors.initials: G
authors.lastname: Puchulo
authors.forename: Pablo
authors.initials: P
authors.lastname: Matar
authors.forename: Guillermo
authors.initials: G
authors.lastname: Mazzolini
mesh_terms: D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007167:Immunotherapy / Q000379:methods*; D023461:Myeloid Progenitor Cells; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D050378:T-Lymphocytes, Regulatory; D019139:Tumor Escape / Q000276:immunology*