title: Extraskeletal effects of vitamin D: facts, uncertainties, and controversies.
abstract: Vitamin D was long viewed as a hormone acting chiefly to regulate calcium-phosphate metabolism and bone mineralization. Over the last decade, however, basic science and clinical researchers have produced a bewildering amount of information on the extraskeletal effects of vitamin D. This article is a review of the clinical and biological actions of vitamin D including effects on the immune system, auto-immune diseases, infections, cancer, metabolic syndrome, fall risk, cognitive function, and muscle function.
authors.affiliation: Service de rhumatologie, CHU d'Angers, université d'Angers, UNAM, 49933 Angers, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Bouvard
authors.forename: Cédric
authors.initials: C
authors.lastname: Annweiler
authors.forename: Agnès
authors.initials: A
authors.lastname: Sallé
authors.forename: Olivier
authors.initials: O
authors.lastname: Beauchet
authors.forename: Daniel
authors.initials: D
authors.lastname: Chappard
authors.forename: Maurice
authors.initials: M
authors.lastname: Audran
authors.forename: Erick
authors.initials: E
authors.lastname: Legrand
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D012307:Risk Factors; D035501:Uncertainty; D014807:Vitamin D / Q000276:immunology* / Q000378:metabolism*
chemical_list: D014807:Vitamin D