title: Determination of 195 pesticide residues in Chinese herbs by gas chromatography-mass spectrometry using analyte protectants.
abstract: The phenomenon known as "matrix-induced enhancement effect" is not only observed in the analysis of pesticides in food, but also in Chinese herbs. Several approaches have been proposed to overcome the matrix-induced effect, but each method has serious limitations. Compared with standard calibration methods, the procedure with adding analyte protectants offers a more convenient and effective route to solve the problem. In the current study, we have analyzed 195 types of pesticides in Chinese herbs by gas chromatography-mass spectrometry (GC-MS), and the compounds that are susceptible to matrix effect were picked up and confirmed. In addition, several analyte protectants were evaluated and the most effective combination was determined. D-ribonic acid-γ-lactone (2 mg/ml) and D-sorbitol (1 mg/ml) were shown to be the best analyte protectants for the analysis of most pesticides.
authors.affiliation: Department of Traditional Chinese Medicine, National Institute for the Control of Pharmaceutical & Biological Products, Beijing 100050, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Jin
authors.forename: Shuang-Cheng
authors.initials: SC
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Rui-Chao
authors.initials: RC
authors.lastname: Lin
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D007783:Lactones / Q000737:chemistry; D010573:Pesticide Residues / Q000032:analysis* / Q000737:chemistry; D012680:Sensitivity and Specificity; D013012:Sorbitol / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D007783:Lactones; D010573:Pesticide Residues; D013012:Sorbitol