title: Quantitative detection of serum survivin and its relationship with prognostic factors in ovarian cancer.
abstract: OBJECTIVE
  This study was conducted to determine the clinical significance of serum survivin in ovarian cancer.
  
  
  METHODS
  A total of 65 patients with ovarian tumors including 21 epithelial ovarian cancer, 22 benign epithelial ovarian tumor, 13 dermoid cyst and 9 endometrioma cases were investigated. All histologic types of cancer were serous carcinoma except for 1 case of undifferentiated carcinoma. ELISA was employed to evaluate the serum survivin levels. For statistical analysis, we used Fisher's exact test, Spearman's correlation coefficient test, the Mann-Whitney U test, the log-rank test and Cox regression analysis.
  
  
  RESULTS
  The survivin level was higher in serous ovarian cancer than in benign epithelial tumors with marginal significance. In ovarian cancer, serum survivin was positively correlated with age, advanced stage and poor disease-free survival. Interestingly, high survivin level positivity was associated with positive peritoneal cytology and omental metastasis of ovarian cancer.
  
  
  CONCLUSIONS
  Our data collectively suggest that serum survivin reflects the peritoneal metastasis of serous ovarian cancer and may thus be useful as a prognostic biomarker.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: No
authors.forename: Yong-Tark
authors.initials: YT
authors.lastname: Jeon
authors.forename: Yong-Beom
authors.initials: YB
authors.lastname: Kim
authors.forename: Yong-Sang
authors.initials: YS
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D003884:Dermoid Cyst / Q000097:blood / Q000175:diagnosis; D004715:Endometriosis / Q000097:blood / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000097:blood*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis; D000077022:Survivin; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D015415:Biomarkers; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin