title: Monitoring of motor disorders in 7-day-old rats with severe hypoxic-ischemic injury of the brain.
abstract: Seven-day old rats were subjected to unilateral ligation of the common carotid artery followed by 2-h exposure to a gas mixture consisting of 8% oxygen and 92% nitrogen. Locomotor function of rats was monitored weekly. Functional deficit in these animals persisted for at least 3 months. The exercise tests of rotarod, hanging, and narrowing track were most informative. Our results can be used in preclinical studies of new drugs for the therapy of perinatal brain injury.
authors.affiliation: V. P. Serbskii State Research Center for Social and Forensic Psychiatry, Russian State Medical University, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Karasev
authors.forename: S V
authors.initials: SV
authors.lastname: Lebedev
authors.forename: T V
authors.initials: TV
authors.lastname: Garats
authors.forename: A M
authors.initials: AM
authors.lastname: Sharibzhanova
authors.forename: A V
authors.initials: AV
authors.lastname: Makarov
authors.forename: N N
authors.initials: NN
authors.lastname: Volodin
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D005260:Female; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology*; D008297:Male; D009069:Movement Disorders / Q000503:physiopathology*; D051381:Rats