title: Giant cell glioblastoma in the cerebrum of a Pembroke Welsh corgi.
abstract: A 6-year-old, neutered female Pembroke Welsh corgi was presented with a 1-month history of ataxia and panting. The clinical signs progressed until the dog became anorexic, obtunded and exhibited circling to the left. At necropsy examination, a mass was detected in the left forebrain, impinging on the cribriform plate. Microscopically, the mass was composed of sheets of round to pleomorphic neoplastic cells with vacuolated cytoplasm. Nuclear atypia, anisocytosis and anisokaryosis were common. Numerous bizarre, multinucleated giant cells containing 60 or more nuclei and giant mononuclear cells were present. The matrix contained abundant reticulin. Immunohistochemistry revealed the neoplastic cells uniformly to express vimentin, and a small number of neoplastic cells expressed glial fibrillary acid protein. A diagnosis of giant cell glioblastoma was made. Although well recognized in man, this tumour has been documented rarely in the veterinary literature.
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. dgiri@ils-inc.com
authors.forename: D K
authors.initials: DK
authors.lastname: Giri
authors.forename: F
authors.initials: F
authors.lastname: Aloisio
authors.forename: F
authors.initials: F
authors.lastname: Alosio
authors.forename: D K
authors.initials: DK
authors.lastname: Ajithdoss
authors.forename: A
authors.initials: A
authors.lastname: Ambrus
authors.forename: J A
authors.initials: JA
authors.lastname: Lidbury
authors.forename: H E
authors.initials: HE
authors.lastname: Hein
authors.forename: B F
authors.initials: BF
authors.lastname: Porter
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D054022:Cerebrum / Q000378:metabolism / Q000473:pathology*; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D014746:Vimentin