title: Nitroxyl antioxidant TPPA-TEMPO increases the efficacy of antitumor therapy on the model of transplantable mouse tumor.
abstract: Nitroxyl antioxidant 4-triphenylphosphonioacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl (TPPA-TEMPO) was synthesized from 4-chloroacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl chloride and triphenylphosphine. Systemic administration of TPPA-TEMPO in the subtoxic dose to mice with lymphosarcoma inhibited tumor growth, but did not prolong animal lifespan. Combined treatment with TPPA-TEMPO and cyclophosphamide increased the efficacy of antitumor therapy: it prolonged animal lifespan and increased the number of recovered mice.
authors.affiliation: N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Kirilyuk
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
authors.forename: N A
authors.initials: NA
authors.lastname: Popova
authors.forename: V P
authors.initials: VP
authors.lastname: Nikolin
authors.forename: E D
authors.initials: ED
authors.lastname: Vasil'eva
authors.forename: I A
authors.initials: IA
authors.lastname: Grigor'ev
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D003497:Cyclic N-Oxides / Q000737:chemistry / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000975:Antioxidants; D003497:Cyclic N-Oxides; D003520:Cyclophosphamide; C003959:TEMPO