title: Synthesis and insecticidal activity of N-tert-butyl-N,N'-diacylhydrazines containing 1,2,3-thiadiazoles.
abstract: N-tert-Butyl-N,N'-diacylhydrazines are nonsteroidal ecdysone agonists used as environmental benign pest regulators. In this paper, two series of new N-tert-butyl-N,N'-diacylhydrazine derivatives containing 1,2,3-thiadiazole were designed and synthesized. All structures of the synthesized compounds were confirmed by proton nuclear magnetic resonance ((1)H NMR), infrared spectroscopy (IR), and high-resolution mass spectrometry (HRMS). Bioasssay results indicated that most of the synthesized compounds possessed good insecticidal activities against Plutella xylostella L. and Culex pipiens pallens as compared with the positive control, tebufenozide. The results of this study indicated that 1,2,3-thiadiazoles, as an important active substructure, could improve or maintain the activity of the dicylhydrazines and favor novel pesticide development.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Nankai University, No. 94 Weijin Road, Nankai District, Tianjin 300071, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Yang
authors.forename: Zhijin
authors.initials: Z
authors.lastname: Fan
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Wu
authors.forename: Youjun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: Mi
authors.forename: Shouxin
authors.initials: S
authors.lastname: Wang
authors.forename: Zhengcai
authors.initials: Z
authors.lastname: Zhang
authors.forename: Haibin
authors.initials: H
authors.lastname: Song
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
mesh_terms: D000818:Animals; D003465:Culex / Q000187:drug effects; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D013830:Thiadiazoles