title: Translational research: not just bench to bedside.
abstract: The translation of proteins within the cell has been increasingly implicated in multiple malignancies as an important regulatory checkpoint. Although evidence continues to mount regarding the role of translation in cancer, questions persist as to how translation is activated and the overall significance in thoracic malignancies. Two recent articles are reviewed here that explore the role of enhanced translation in tumorigenesis and prognosis.
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: McCauley
authors.forename: Jonathan
authors.initials: J
authors.lastname: D'Cunha
mesh_terms: D015197:Carcinogenicity Tests; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008910:Minnesota; D010766:Phosphorylation; D011379:Prognosis; D058570:TOR Serine-Threonine Kinases / Q000187:drug effects; D013899:Thoracic Neoplasms / Q000188:drug therapy / Q000401:mortality; D057170:Translational Research, Biomedical
chemical_list: C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases