title: [Different procedures of alimentary tract reconstruction after subtotal distal gastrectomy in dogs].
abstract: OBJECTIVE
  To explore an ideal procedure of alimentary tract reconstructions after subtotal distal gastrectomy.
  
  
  METHODS
  Thirty-two healthy adult beagle dogs were randomly divided into experimental groups A, B, C and control group (n=8). Groups A, B, C operated by subtotal distal gastrectomy underwent 3 different reconstruction methods: continual jejunal interposition (CJI), Billroth II and Roux-en-Y. The control group received a sham operation. Dogs were observed for 12 weeks post-operation. The different parameters of body weight, food intake, PNI (prognostic nutritional index) and peripheral blood concentration of ghrelin were measured in 4 groups.
  
  
  RESULTS
  The body weight, food intake and PNI in Groups A, B, C decreased significantly at post-operation versus pre-operation. There was a slow elevation of body weight, food intake and PNI at Week 12. Group A was significantly better than Groups B and C (P<0.05) while there was no significant difference between Groups B and C. The plasma ghrelin concentrations in Groups A, B, C were significantly reduced at Day 1 post-operation versus pre-operation. But no difference was observed among Groups A, B and C. However an elevated ghrelin concentration was observed at Week 1 post-operation. At Week 12 post-operation, the plasma ghrelin concentration in Group A increased significantly versus Groups B and C (both P<0.05). However, the plasma ghrelin concentration, food intake and PNI were not significantly changed in control group (P>0.05).
  
  
  CONCLUSIONS
  The CJI reconstruction procedure is ideally suited for the preservation of duodenal passage after subtotal distal gastrectomy. Subsequently it leads to a significant elevation of circulating ghrelin concentration and a rapid post-operative recovery of food intake, body weight and PNI.
authors.affiliation: Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China. yezaiyuan@126.com
authors.forename: Zai-yuan
authors.initials: ZY
authors.lastname: Ye
authors.forename: Yuan-shui
authors.initials: YS
authors.lastname: Sun
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yuan-yu
authors.initials: YY
authors.lastname: Wang
authors.forename: Qiao-qiong
authors.initials: QQ
authors.lastname: Dai
authors.forename: Qin-shu
authors.initials: QS
authors.lastname: Shao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Zhen-ye
authors.initials: ZY
authors.lastname: Lü
authors.forename: Ji
authors.initials: J
authors.lastname: Xu
mesh_terms: D000713:Anastomosis, Roux-en-Y; D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D013505:Digestive System Surgical Procedures / Q000379:methods*; D004285:Dogs; D005260:Female; D005743:Gastrectomy; D041981:Gastrointestinal Tract / Q000601:surgery*; D054439:Ghrelin / Q000097:blood; D007583:Jejunum / Q000601:surgery*; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods*
chemical_list: D054439:Ghrelin