title: Large B-cell lymphoma with an unusual infiltrating pattern: report of two cases.
abstract: Large B-cell lymphoma presents with the most varied infiltrating patterns and morphologies. Here we report two cases of unusual large B-cell lymphoma in two old female patients. Both lymphomas show: 1) scattered and clustered large B-cells infiltrating the periphery of polyclonal lymphoid nodules; 2) large B-cells with an immunoblastic morphology; 3) large B-cell infiltration associated with vascular proliferation; 4) coexisting lymphoid nodules with hyaline vascular proliferation. The first case took an aggressive clinical course with transformation into acute leukemia, and imparted a short patient survival, whereas the second case responded to chemotherapy, experienced a local recurrence and long survival for >7 years. To our knowledge, these are the first reported cases of large B-cell lymphomas with a paranodular infiltrating pattern, immunoblastic morphology, and associated vascular proliferation.
authors.affiliation: Department of Pathology, University of Maryland Medical Center Baltimore, MD, USA.
authors.forename: Neil G
authors.initials: NG
authors.lastname: Haycocks
authors.forename: X Frank
authors.initials: XF
authors.lastname: Zhao
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000098:blood supply / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D018482:Muscle, Skeletal / Q000473:pathology; D009361:Neoplasm Invasiveness; D018365:Neoplasm, Residual; D009389:Neovascularization, Pathologic
chemical_list: D004273:DNA, Neoplasm