title: [Changes of erythrocyte rheology properties in immigrant subjects at different altitudes and its mechanism].
abstract: OBJECTIVE
  To explore the influence of altitude changes on red blood cell rheology properties and negative effects caused by it and possible mechanism.
  
  
  METHODS
  Erythrocyte filtration index (EFI), superoxide dismutase (SOD) and Malondialdehyde (MDA) were detected the mechanisms in which EFI changes.
  
  
  RESULTS
  EFI increased with increasing altitudes and there was a significant different in EFI at the different range of Hb at the same altitude and a significant different in EFI at the similar range of Hb at different altitudes. Correlative analyses showed that EFI was in a negative correlation with SOD activities, relations between EFI and MDA were on the contrary.
  
  
  CONCLUSIONS
  Changes of SOD and MDA with increasing altitudes lead to abnormalities of erythrocyte rheology properties in healthy subjects.
authors.affiliation: Geriatrics Institute, People's Hospital of Qinghai Province, Xining 810007.
authors.forename: A Q
authors.initials: AQ
authors.lastname: Xi
mesh_terms: D000328:Adult; D000531:Altitude; D001809:Blood Viscosity; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000378:metabolism; D012212:Rheology; D013482:Superoxide Dismutase / Q000032:analysis; D014171:Transients and Migrants; D055815:Young Adult
chemical_list: D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D013482:Superoxide Dismutase