title: The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients.
abstract: BACKGROUND
  The cannabinoid receptor gene 1 (CNR1) encodes the human cannabinoid receptor CB1. This receptor has a widespread distribution in the central nervous system (CNS), the main ligands being anandamide, 2-araquidonoil glycerol and marijuana constituents. There is evidence to suggest an anti-neoplastic effect of these ligands in glial tissues mediated through stimulation of the receptor.
  
  
  METHODS
  We have studied the G1359A polymorphism of the gene CNR1 with a TaqMan allelic discrimination assay in 200 patients diagnosed with glioma, 109 patients diagnosed with meningioma and 403 healthy subjects. Results Genotypic distribution of the G1359A CNR1 polymorphism in glioma patients showed significant differences when compared to the control group.
  
  
  CONCLUSIONS
  Our results suggest that allele G of the CNR1 gene could be associated with a lower susceptibility to glioma.
authors.affiliation: Cancer Research Center-IBMCC, University of Salamanca-CSIC, Salamanca, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Núñez
authors.forename: Sandra
authors.initials: S
authors.lastname: Perdomo
authors.forename: Juan
authors.initials: J
authors.lastname: Moreta
authors.forename: Ángel
authors.initials: Á
authors.lastname: Santos-Briz
authors.forename: Rogelio
authors.initials: R
authors.lastname: González-Sarmiento
mesh_terms: D000328:Adult; D000483:Alleles; D016543:Central Nervous System Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics; D008579:Meningioma / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D013030:Spain
chemical_list: C571130:CNR1 protein, human; D043884:Receptor, Cannabinoid, CB1