title: Circadian transcription profile of mouse breast cancer under light-dark and dark-dark conditions.
abstract: The circadian clock exists in virtually every cell and regulates key biological processes in cells and tissues. Even in cancer cells, DNA synthesis, cell division and tumor growth are gated by the circadian clock. This study examined the gene expression profiles of transplanted mouse breast tumor cells under normal light-dark (LD) as well as constant dark (DD) conditions. It was found that the overall percentage of rhythmic transcripts in breast tumor tissue was lower than that in normal tissue. Few transcripts had unaltered rhythmic expression patterns under both LD and DD conditions. Most rhythmic transcripts in DD displayed 12h or shorter periods. These results suggest that in addition to the circadian clock control of gene transcription, altering light, feeding, physical activity and other factors characteristically affect the expression of many genes.
authors.affiliation: Medical Chronobiology Laboratory, Dorn Research Institute,WJB Dorn VA Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209, U.S.A.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Oh
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yang
authors.forename: Alex
authors.initials: A
authors.lastname: Friedman
authors.forename: Christine M
authors.initials: CM
authors.lastname: Ansell
authors.forename: Jovelyn
authors.initials: J
authors.lastname: Du-Quiton
authors.forename: Dinah F
authors.initials: DF
authors.lastname: Quiton
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Wood
authors.forename: William J M
authors.initials: WJ
authors.lastname: Hrushesky
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D049109:Cell Proliferation / Q000528:radiation effects*; D002940:Circadian Rhythm / Q000502:physiology*; D003624:Darkness; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D008027:Light; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger