title: Formulation and pharmacokinetic evaluation of hard gelatin capsule encapsulating lyophilized Vasa Swaras for improved stability and oral bioavailability of vasicine.
abstract: The oral bioavailability of vasicine (1) was investigated in hard gelatin capsules of lyophilized Vasa Swaras (aqueous extract of Adhatoda vasica Nees.,Fam.: Acanthaceae) The rat pharmacokinetic profile of lyophilized Vasa Swaras, Vasa Swaras, vasicine (1) (chief marker compounds of A. vasica) and a marketed capsule formulation of A. vasica were compared. Vasicine (1) was found to be more orally bioavailable from lyophilized Vasa Swaras, with an overall minor conversion to vasicinone (2).
authors.affiliation: Department of Natural Products, National Institute of Pharmaceutical Education and Research-Ahmedabad, Ahmedabad, Gujarat, India.
authors.forename: Tejas
authors.initials: T
authors.lastname: Vyas
authors.forename: Ranjeet Prasad
authors.initials: RP
authors.lastname: Dash
authors.forename: Sheetal
authors.initials: S
authors.lastname: Anandjiwala
authors.forename: Manish
authors.initials: M
authors.lastname: Nivsarkar
mesh_terms: D000470:Alkaloids / Q000378:metabolism / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D002214:Capsules; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004355:Drug Stability; D005612:Freeze Drying; D005780:Gelatin; D027902:Justicia / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000378:metabolism / Q000493:pharmacokinetics*; D011799:Quinazolines / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000470:Alkaloids; D002214:Capsules; D010936:Plant Extracts; D011799:Quinazolines; C019592:vasicine; D005780:Gelatin