title: Optical system based on time-gated, intensified charge-coupled device camera for brain imaging studies.
abstract: An imaging system for brain oxygenation based on a time-gated, intensified charge-coupled device camera was developed. It allows one to image diffusely reflected light from an investigated medium at defined time windows delayed with respect to the laser pulse. Applying a fast optomechanical switch to deliver the light at a wavelength of 780 nm to nine source fibers allowed one to acquire images in times as short as 4 s. Thus, the system can be applied in in vivo studies. The system was validated in phantom experiments, in which absorbing inclusions were localized at different depths and different lateral positions. Then, the decrease in absorption of the brain tissue related to increase in oxygenation was visualized in the motor cortex area during finger tapping by a healthy volunteer.
authors.affiliation: Polish Academy of Sciences, Institute of Biocybernetics and Biomedical Engineering, Warsaw 02-109, Poland. psawosz@ibib.waw.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Sawosz
authors.forename: Michal
authors.initials: M
authors.lastname: Kacprzak
authors.forename: Norbert
authors.initials: N
authors.lastname: Zolek
authors.forename: Wojciech
authors.initials: W
authors.lastname: Weigl
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Wojtkiewicz
authors.forename: Roman
authors.initials: R
authors.lastname: Maniewski
authors.forename: Adam
authors.initials: A
authors.lastname: Liebert
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D006801:Humans; D008297:Male; D055096:Optical Devices; D010100:Oxygen / Q000378:metabolism*; D012666:Semiconductors; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation*
chemical_list: D010100:Oxygen