title: Evaluation of the effects of thiopental, propofol, and etomidate on glomerular filtration rate measured by the use of dynamic computed tomography in dogs.
abstract: OBJECTIVE
  To evaluate the effects of thiopental, propofol, and etomidate on glomerular filtration rate (GFR) measured by the use of dynamic computed tomography in dogs.
  
  
  METHODS
  17 healthy Beagles.
  
  
  METHODS
  Dogs were randomly assigned to receive 2 mg of etomidate/kg (n = 5), 6 mg of propofol/kg (7), or 15 mg of thiopental/kg (5) during induction of anesthesia; anesthesia was subsequently maintained by isoflurane evaporated in 100% oxygen. A 1 mL/kg dosage of a 300 mg/mL solution of iohexol was administered at a rate of 3 mL/s during GFR measurement. Regions of interest of the right kidney were manually drawn to exclude vessels and fatty tissues and highlight the abdominal portion of the aorta. Iohexol clearance per unit volume of the kidney was calculated by use of Patlak plot analysis.
  
  
  RESULTS
  Mean ± SD weight-adjusted GFR of the right kidney after induction of anesthesia with thiopental, propofol, and etomidate was 2.04 ± 0.36 mL/min/kg, 2.06 ± 0.29 mL/min/kg, and 2.14 ± 0.43 mL/min/kg, respectively. However, no significant differences in weight-adjusted GFR were detected among the treatment groups.
  
  
  CONCLUSIONS
  Results obtained for the measurement of GFR in anesthetized dogs after anesthetic induction with etomidate, propofol, or thiopental and maintenance with isoflurane did not differ significantly. Therefore, etomidate, propofol, or thiopental can be used in anesthesia-induction protocols that involve the use of isoflurane for maintenance of anesthesia without adversely affecting GFR measurements obtained by the use of dynamic computed tomography in dogs.
authors.affiliation: Department of Medical Imaging, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea.
authors.forename: Jinhwa
authors.initials: J
authors.lastname: Chang
authors.forename: Sujin
authors.initials: S
authors.lastname: Kim
authors.forename: Joohyun
authors.initials: J
authors.lastname: Jung
authors.forename: Heechun
authors.initials: H
authors.lastname: Lee
authors.forename: Dongwoo
authors.initials: D
authors.lastname: Chang
authors.forename: Youngwon
authors.initials: Y
authors.lastname: Lee
authors.forename: Inhyung
authors.initials: I
authors.lastname: Lee
authors.forename: Junghee
authors.initials: J
authors.lastname: Yoon
authors.forename: Mincheol
authors.initials: M
authors.lastname: Choi
mesh_terms: D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs / Q000502:physiology*; D005045:Etomidate / Q000494:pharmacology; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D008297:Male; D015742:Propofol / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology; D014057:Tomography, X-Ray Computed
chemical_list: D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol; D005045:Etomidate