title: Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease.
abstract: Nuclear receptors (NRs) play a key role in the transcriptional control of critical steps of hepatobiliary transport and phase I/II metabolism of endo- and xenobiotics such as bile acids and drugs. Apart from these metabolic roles, NRs may also play a key role in the control of hepatic inflammation. Hereditary and acquired alterations of NRs contribute to our understanding of the pathogenesis of cholestasis and gallstone disease. Moreover, NRs may represent attractive drug targets for these disorders. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.
authors.affiliation: Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University Graz, Austria.
authors.forename: Thierry
authors.initials: T
authors.lastname: Claudel
authors.forename: Gernot
authors.initials: G
authors.lastname: Zollner
authors.forename: Martin
authors.initials: M
authors.lastname: Wagner
authors.forename: Michael
authors.initials: M
authors.lastname: Trauner
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002779:Cholestasis / Q000503:physiopathology*; D042882:Gallstones / Q000503:physiopathology*; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*
chemical_list: D001647:Bile Acids and Salts; D018160:Receptors, Cytoplasmic and Nuclear