title: Effects of a calcium phosphate coating on the osseointegration of endosseous implants in a rabbit model.
abstract: OBJECTIVE
  The aim of the present study was to evaluate a Ca-P coated implant surface in a rabbit model. The Ca-P surface (test) was compared to the titanium porous oxide surface (control) in terms of bone-to-implant contact (BIC) and removal torque value.
  
  
  METHODS
  Two hundred and sixteen dental implants were inserted in the tibia and in the femur of 36 rabbits. One hundred and eight were represented by Ca-P oxidized surface implant and other 108 were titanium porous oxide surface modified implants. Each rabbit received six implants. Animals were sacrificed after 2, 4 and 9 weeks of healing. Each group included 12 rabbits. The femoral implant and the proximal implant of the tibia of each animal were subjected to the histologic analysis and the distal implants of the tibia underwent removal torque test (RTQ).
  
  
  RESULTS
  Histological analysis in terms of BIC and RTQ did not revealed any significant difference between the Ca-P oxidized surface and the oxidized surface at 2 and 4 weeks. At 9 weeks, the oxidized surface demonstrated better results in terms of RTQ in the tibia.
  
  
  CONCLUSIONS
  In conclusion, findings from the present study suggested that the Ca-P coating had no beneficial effect in improving bonding strength at the bone-implant interface either at 2, 4 and 9 weeks.
authors.affiliation: Department of Implant Dentistry, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyDepartment of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyCRABCC - Reseach Center on Biotechnological Applications, Università degli studi di Milano, Milano, ItalyDepartment of Periodontics, School of dental Medicine, University of Pennsylvania, Philadelphia, PA, USAPrivate Practice, Pessano con Bornago, Milano, ItalyChairman, Department of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Fontana
authors.affiliation: Department of Implant Dentistry, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyDepartment of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyCRABCC - Reseach Center on Biotechnological Applications, Università degli studi di Milano, Milano, ItalyDepartment of Periodontics, School of dental Medicine, University of Pennsylvania, Philadelphia, PA, USAPrivate Practice, Pessano con Bornago, Milano, ItalyChairman, Department of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Rocchietta
authors.affiliation: Department of Implant Dentistry, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyDepartment of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyCRABCC - Reseach Center on Biotechnological Applications, Università degli studi di Milano, Milano, ItalyDepartment of Periodontics, School of dental Medicine, University of Pennsylvania, Philadelphia, PA, USAPrivate Practice, Pessano con Bornago, Milano, ItalyChairman, Department of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Addis
authors.affiliation: Department of Implant Dentistry, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyDepartment of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyCRABCC - Reseach Center on Biotechnological Applications, Università degli studi di Milano, Milano, ItalyDepartment of Periodontics, School of dental Medicine, University of Pennsylvania, Philadelphia, PA, USAPrivate Practice, Pessano con Bornago, Milano, ItalyChairman, Department of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, Italy.
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.affiliation: Department of Implant Dentistry, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyDepartment of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyCRABCC - Reseach Center on Biotechnological Applications, Università degli studi di Milano, Milano, ItalyDepartment of Periodontics, School of dental Medicine, University of Pennsylvania, Philadelphia, PA, USAPrivate Practice, Pessano con Bornago, Milano, ItalyChairman, Department of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Zanotti
authors.affiliation: Department of Implant Dentistry, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyDepartment of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, ItalyCRABCC - Reseach Center on Biotechnological Applications, Università degli studi di Milano, Milano, ItalyDepartment of Periodontics, School of dental Medicine, University of Pennsylvania, Philadelphia, PA, USAPrivate Practice, Pessano con Bornago, Milano, ItalyChairman, Department of Periodontology, Università degli studi di Milano, Fondazione IRCCS Ca' Grande, Milano, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Simion
mesh_terms: D000818:Animals; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D003799:Dental Stress Analysis; D020878:Device Removal; D020007:Implants, Experimental; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000502:physiology*; D011817:Rabbits; D018709:Statistics, Nonparametric; D013499:Surface Properties; D013977:Tibia / Q000601:surgery; D019415:Torque
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants