title: [CDK4, a specific target in the treatment of lung adenocarcinomas mutated for KRAS].
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubus
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000628:therapy*; D000236:Adenoma / Q000188:drug therapy / Q000235:genetics / Q000628:therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016922:Cellular Senescence / Q000187:drug effects / Q000235:genetics; D051358:Cyclin-Dependent Kinase 4 / Q000037:antagonists & inhibitors* / Q000502:physiology; D004354:Drug Screening Assays, Antitumor; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D011905:Genes, ras; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000628:therapy*; D051379:Mice; D058990:Molecular Targeted Therapy; D009154:Mutation; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000502:physiology; D011725:Pyridines / Q000627:therapeutic use; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000627:therapeutic use*; D018631:ras Proteins
chemical_list: D000970:Antineoplastic Agents; C117307:KRAS protein, human; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D011725:Pyridines; D034741:RNA, Small Interfering; C495900:CDK4 protein, human; C495902:Cdk4 protein, mouse; D051358:Cyclin-Dependent Kinase 4; C495971:Hras protein, mouse; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins; C500026:palbociclib