title: Renal biopsy in type 2 diabetes: timing of complications and evaluating of safety in Chinese patients.
abstract: OBJECTIVE
  It has been recognized that renal lesions in patients with diabetes often have other causes of renal damage concomitantly. Renal biopsy is a valuable tool to provide histological evidence. However, the safety in patients with type 2 diabetes receiving renal biopsy is not well evaluated. This study was conducted to monitor the dynamic complications and to evaluate the safety of biopsy in diabetic patients.
  
  
  METHODS
  A prospective observation was performed on 130 patients with type 2 diabetes and 150 patients not undergoing renal biopsy. The complications were monitored at 4 h, 8 h, 24 h, 48 h and 72 h sequentially after biopsy.
  
  
  RESULTS
  Haematoma was observed in 34 (26.15%) patients with diabetes and 50 (33.33%) in controls (P=0.19). The timing of large haematoma peaked at 4 h. Gross haematuria occurred in 12 (9.23%) diabetic patients and eight (5.33%) controls (P=0.207). It happened mainly within 8 h. Renal pathological diagnosis showed 96 (73.85%) cases with diabetic nephropathy and 34 (26.15%) cases with non-diabetic renal disease.
  
  
  CONCLUSIONS
  Renal biopsy in patients with type 2 diabetes is safe. The frequency of complications after renal biopsy in diabetes is no higher than those without diabetes. The complications mostly happened within 8 h, especially within 4 h. Biopsy is also very necessary to rule out other chronic renal diseases in diabetes.
authors.affiliation: Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Zhang
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Ge
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Li
authors.forename: Hong-Lang
authors.initials: HL
authors.lastname: Xie
authors.forename: Lei-Shi
authors.initials: LS
authors.lastname: Li
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Liu
mesh_terms: D000328:Adult; D001706:Biopsy / Q000009:adverse effects*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000473:pathology; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology; D006406:Hematoma / Q000209:etiology*; D006417:Hematuria / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000209:etiology / Q000473:pathology; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D055815:Young Adult