title: (3S,4R)-4-(4-Fluoro-phen-yl)-3-(hydroxy-meth-yl)piperidinium chloride.
abstract: The title compound, C(12)H(17)FNO(+)·Cl(-), is a degradation impurity of paroxetine hydro-chloride hemihydrate (PAXIL), an anti-depressant belonging to the group of drugs called selective serotonin reuptake inhibitors (SSRIs). Similar to the paroxetine hydro-chloride salt with protonation having taken place on the basic piperidine ring, the degradation impurity also exists as the hydro-chloride salt. The cyclic six-membered piperidinium ring adopts a chair conformation with the hydroxy-methyl and 4-fluoro-phenyl groups in the equatorial positions. The ions form a tape along the b axis through charge-assisted N(+)-H⋯Cl(-) hydrogen bonds; these tapes are connected by O-H⋯Cl(-) hydrogen bonds along the a axis.
authors.forename: M
authors.initials: M
authors.lastname: Nirmala
authors.forename: B R
authors.initials: BR
authors.lastname: Sreekanth
authors.forename: Peddy
authors.initials: P
authors.lastname: Vishweshwar
authors.forename: J
authors.initials: J
authors.lastname: Moses Babu
authors.forename: Y
authors.initials: Y
authors.lastname: Anjaneyulu