title: Dentin hypersensitivity and oxalates: a systematic review.
abstract: Treatment of dentin hypersensitivity with oxalates is common, but oxalate efficacy remains unclear. Our objective was to systematically review clinical trials reporting an oxalate treatment compared with no treatment or placebo with a dentin hypersensitivity outcome. Risk-of-bias assessment and data extraction were performed independently by two reviewers. Standardized mean differences (SMD) were estimated by random-effects meta-analysis. Of 677 unique citations, 12 studies with high risk-of-bias were included. The summary SMD for 3% monohydrogen-monopotassium oxalate (n = 8 studies) was -0.71 [95% Confidence Interval: -1.48, 0.06]. Other treatments, including 30% dipotassium oxalate (n = 1), 30% dipotassium oxalate plus 3% monohydrogen monopotassium oxalate (n = 3), 6% monohydrogen monopotassium oxalate (n = 1), 6.8% ferric oxalate (n = 1), and oxalate-containing resin (n = 1), also were not statistically significantly different from placebo treatments. With the possible exception of 3% monohydrogen monopotassium oxalate, available evidence currently does not support the recommendation of dentin hypersensitivity treatment with oxalates.
authors.affiliation: Dental Public Health Sciences, Box 357475, School of Dentistry, University of Washington, Seattle, WA 98195-7475, USA. silvajcc@u.washington.edu
authors.forename: J
authors.initials: J
authors.lastname: Cunha-Cruz
authors.forename: J R
authors.initials: JR
authors.lastname: Stout
authors.forename: L J
authors.initials: LJ
authors.lastname: Heaton
authors.forename: J C
authors.initials: JC
authors.lastname: Wataha
mesh_terms: D015982:Bias; D018849:Controlled Clinical Trials as Topic; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D006801:Humans; D010070:Oxalates / Q000627:therapeutic use*; D010147:Pain Measurement
chemical_list: D057133:Dentin Desensitizing Agents; D010070:Oxalates