title: Jun dimerization protein 2 controls senescence and differentiation via regulating histone modification.
abstract: Transcription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences. JDP2 plays a key role as a repressor of adipocyte differentiation by regulation of the expression of the gene C/EBPδ via inhibition of histone acetylation. Moreover, JDP2-deficient mouse embryonic fibroblasts (JDP2(-/-) MEFs) are resistant to replicative senescence. JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16(Ink4a), resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27). Therefore, it seems that chromatin-remodeling factors, including the PRC complex controlled by JDP2, may be important players in the senescence program. The novel mechanisms that underline the action of JDP2 in inducing cellular senescence and suppressing adipocyte differentiation are reviewed.
authors.affiliation: Center of Excellence for Environmental Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, San Ming District, Kaohsiung 80708, Taiwan.
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Huang
authors.forename: Hitomi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Shin-Wei
authors.initials: SW
authors.lastname: Wang
authors.forename: Chia-Chen
authors.initials: CC
authors.lastname: Ku
authors.forename: Ying-Chu
authors.initials: YC
authors.lastname: Lin
authors.forename: Shyh-Shin
authors.initials: SS
authors.lastname: Chiou
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.forename: Deng-Chyang
authors.initials: DC
authors.lastname: Wu
authors.forename: Eing-Mei
authors.initials: EM
authors.lastname: Tsai
authors.forename: Shigeo
authors.initials: S
authors.lastname: Saito
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Kazunari K
authors.initials: KK
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D006657:Histones / Q000502:physiology*; D006801:Humans; D051379:Mice; D012097:Repressor Proteins / Q000502:physiology*
chemical_list: D006657:Histones; C491387:JDP2 protein, human; C491386:Jundp2 protein, mouse; D012097:Repressor Proteins