title: NF-κB, inflammation, and metabolic disease.
abstract: Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.
authors.affiliation: Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Rebecca G
authors.initials: RG
authors.lastname: Baker
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Hayden
authors.forename: Sankar
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008659:Metabolic Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D000097782:NF-kappaB-Inducing Kinase
chemical_list: D018836:Inflammation Mediators; D016328:NF-kappa B; D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase