title: Induced pluripotent stem cell-derived human platelets: one step closer to the clinic.
abstract: The era of induced pluripotent stem (iPS) cells carries with it the promise of virtually unlimited sources of autologous cells for regenerative medicine. However, efficiently differentiating iPS cells into fully functional mature cell types remains challenging. A new study reporting the formation of fully functional platelets from human iPS (hiPS) cells improves upon recent efforts to generate this enucleated cell type, which remains in high demand for therapeutic transfusions. Notably, their lack of nucleus renders platelets unable to retain the pluripotent or tumorigenic properties of iPS cells.
authors.affiliation: Differentiation and Cancer Program, Center for Genomic Regulation, 08003 Barcelona, Spain.
authors.forename: Christos
authors.initials: C
authors.lastname: Gekas
authors.forename: Thomas
authors.initials: T
authors.lastname: Graf
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D017713:Platelet Transfusion / Q000379:methods / Q000639:trends; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D013921:Thrombocytopenia / Q000628:therapy
chemical_list: D016271:Proto-Oncogene Proteins c-myc