title: Rifampin-bonded vascular grafts and postoperative infections.
abstract: Postoperative wound and graft infections remain a major challenge for vascular surgeons. The bonding of antimicrobial substances on the graft material has been considered for many years, but the demonstration of safety and efficacy of these techniques is far from evident. Among the different proposed options, bonding of rifampin to the grafts has been the most evaluated technique, both experimentally and clinically. The objective of this review was to present and analyze the available data on rifampin-bonding and the possible evolutions of this technique to improve the resistance of vascular prostheses.
authors.affiliation: Department of Vascular Surgery, Ambroise Paré University Hospital, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, France. olivier.goeau-brissonniere@apr.aphp.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Goëau-Brissonnière
authors.forename: Isabelle
authors.initials: I
authors.lastname: Javerliat
authors.forename: Fabien
authors.initials: F
authors.lastname: Koskas
authors.forename: Marc
authors.initials: M
authors.lastname: Coggia
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Pechère
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D004285:Dogs; D019317:Evidence-Based Medicine; D006801:Humans; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000517:prevention & control*; D012293:Rifampin / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D012293:Rifampin