title: Cystatin C estimated renal dysfunction predicts T wave axis deviation in US adults: results from NHANES III.
abstract: Patients with impaired kidney function are at increased risk of ventricular arrhythmia and sudden death. The association between chronic kidney disease and frontal T wave axis deviation, a cardiovascular risk factor, in individuals without heart disease is unexplored and unknown. To test the hypothesis that chronic kidney disease predicts frontal T-wave axis deviation, American participants 40 years of age or older from NHANES III, were categorized as having and not having chronic kidney disease based on glomerular filtration rates estimated by both serum cystatin C and serum creatinine and serum creatinine alone. Frontal T-wave axis deviation was measured from the standard 12-lead electrocardiogram. Multivariable adjustments for age, ace, smoking, metabolic syndrome, albuminuria, left ventricular mass, QRS duration and heart rate were performed. In multivariable weighted regression analysis, the odds ratio for abnormal frontal T wave axis deviations and their corresponding 95% CIs in patients with decreased glomerular filtration rate determined by an equation included cystatin and creatinine was 1.90 (1.20-3.32). The odds ratio of frontal T wave axis deviation due to decreased kidney function, determined using an equation included serum creatinine alone, was 1.65 (1.10-2.90). This study suggests that abnormal frontal T wave axis deviation abnormalities occur in subjects with chronic kidney disease. Those with decline in renal function should be considered at risk for potentially serious T-wave associated arrhythmias and thus carefully monitored.
authors.affiliation: Epidemiology Department, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, USA. mohammed.el-faramawi@unthsc.edu
authors.forename: Mohammed F
authors.initials: MF
authors.lastname: Faramawi
authors.forename: James L
authors.initials: JL
authors.lastname: Caffrey
authors.forename: Jamshid
authors.initials: J
authors.lastname: Amanzadeh
authors.forename: Lakpa Diku
authors.initials: LD
authors.lastname: Sharpa
authors.forename: Raquel
authors.initials: R
authors.lastname: Qualls-Hampton
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D055316:Cystatin C / Q000097:blood*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine