title: Drug interaction between rifampicin and sirolimus in transplant patients.
abstract: We report two cases of drug interaction between rifampicin and sirolimus in renal trans-plant patients who were diagnosed with tuberculosis after transplantation and induction of immuno-suppressive therapy with sirolimus. The dosage of sirolimus had to be increased, in one case up to six-fold and in the second case up to five-fold, to maintain serum levels after starting the rifampicin. The two patients tolerated the treatment well, with no signs of tuberculosis and good renal function.
authors.affiliation: Transplant Unit, Department of Surgery and Medicine and the Medical Research Council Liver Research Centre, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
authors.forename: B T
authors.initials: BT
authors.lastname: Ngo
authors.forename: M
authors.initials: M
authors.lastname: Pascoe
authors.forename: Delawir
authors.initials: D
authors.lastname: Khan
mesh_terms: D000328:Adult; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects*; D020123:Sirolimus / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000904:Antibiotics, Antitubercular; D007166:Immunosuppressive Agents; D012293:Rifampin; D020123:Sirolimus