title: [Antimicrobial susceptibility, capsular serotypes and clonal relationship of invasive streptococcus pneumoniae isolates in adult population of the Bio-Bio region, Chile. 2005-2006].
abstract: Streptococcus pneumoniae infections constitute a public health problem. In our country there is scarce information regarding isolates from bacteraemic episodes in adult population. The antibiotic susceptibility, serotypes and clonal relationship of 56 isolates of S. pneumoniae from adult patients with bacteraemic infections in Concepcion-Talcahuano, Bio-Bio Region, Chile, were studied. Resistance to tetracycline (21.4%), trimethoprim/ sulfamethoxazole (18%), erythromycin (18%), chloramphenicol (7%) and 1 penicillin resistant isolate from a meningeal focus (2%) was found. Also, all the isolates were susceptible to cefotaxime, levofloxacin, moxifloxacin and vancomycin. A wide variety of capsular serotypes was demonstrated, with predominance of serotypes 1, 5, 23F, 7F and 3. The macrorestriction analysis by pulse field electrophoresis revealed 31 electrophoretic patterns and 12 clonal groups, discarding a predominant clone. According to the results, at least, 80% of the S. pneumoniae serotypes isolated from bacteraemic adult patients are included in the available commercial vaccine.
authors.affiliation: Universidad de Concepción, Chile. Facultad de Ciencias Biológicas. Departamento Microbiología.
authors.forename: Cristian
authors.initials: C
authors.lastname: Aguilera R
authors.forename: Gerardo
authors.initials: G
authors.lastname: González R
authors.forename: Helia
authors.initials: H
authors.lastname: Bello T
authors.forename: Sergio
authors.initials: S
authors.lastname: Mella M
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Blamey D
authors.forename: Henriette
authors.initials: H
authors.lastname: Chabouty G
authors.forename: Juan C
authors.initials: JC
authors.lastname: Hormazábal O
authors.forename: Aurora
authors.initials: A
authors.lastname: Maldonado B
authors.forename: Bianca
authors.initials: B
authors.lastname: Rojas U
authors.forename: Mabel
authors.initials: M
authors.lastname: Seoane M
authors.forename: Mariana
authors.initials: M
authors.lastname: Domínguez Y
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002677:Chile / Q000453:epidemiology; D002701:Chloramphenicol / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D016521:Electrophoresis, Gel, Pulsed-Field; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects*; D013752:Tetracycline / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D002701:Chloramphenicol; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013752:Tetracycline