title: [Effect of fetus hypobaric hypoxia on NMDA receptor of hippocampus neurons].
abstract: OBJECTIVE
  To study the effect of fetus hypobaric hypoxia on the number and channel character of NMDA receptor of hippocampus neurons.
  
  
  METHODS
  Use in situ hybridization and patch-clamp techniques.
  
  
  RESULTS
  After hypobaric hypoxia the number of NMDA mRNA positive neurons was decreased, the open probability of NMDA receptor was reduced, the open time constant was decreased, the close time constant was increased.
  
  
  CONCLUSIONS
  Hypobaric hypoxia may change the development of NMDA receptor in fetus rat, then maybe effect learning and memory.
authors.affiliation: Department of Neurobiology, The Third Military Medical University, Chongqing 400038, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.forename: Huai-zhen
authors.initials: HZ
authors.lastname: Ruan
authors.forename: Xiao-tang
authors.initials: XT
authors.lastname: Fan
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D005333:Fetus / Q000503:physiopathology; D006624:Hippocampus / Q000166:cytology / Q000503:physiopathology*; D017403:In Situ Hybridization; D019585:Intracranial Hypotension / Q000503:physiopathology; D016202:N-Methylaspartate / Q000378:metabolism; D009474:Neurons / Q000473:pathology*; D018408:Patch-Clamp Techniques; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate