title: Chlamydia psittaci Infection in nongastrointestinal extranodal MALT lymphomas and their precursor lesions.
abstract: Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence of Chlamydia psittaci, Chlamydia pneumoniae, and Chlamydia trachomatis DNA in 47 nongastrointestinal and 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, and 27 autoimmune precursor lesions by polymerase chain reaction amplification and direct sequencing. In 47 nongastrointestinal MALT lymphomas, 13 (28%) were positive for C psittaci DNA compared with 4 (11%) of 37 nonmalignant control samples (P = .09). C psittaci was detected at variable frequencies in MALT lymphomas of different sites: lung, 100% (5/5; P < .01); thyroid gland, 30% (3/10; P > .05); salivary gland, 13% (2/15; P > .05); ocular adnexa, 15% (2/13); and skin, 25% (1/4). Of 27 autoimmune precursor lesions (11 Hashimoto thyroiditis and 16 Sjögren syndrome), 11 (41%) contained C psittaci DNA. Only 1 (7%) of 14 gastrointestinal MALT lymphomas was positive for C psittaci. All specimens were negative for C trachomatis and C pneumoniae. Besides ocular adnexal lymphomas, C psittaci infection is associated with nongastrointestinal MALT lymphomas and autoimmune precursor lesions, suggesting possible involvement of C psittaci-induced antigenic-driven MALT lymphomagenesis.
authors.affiliation: Department of Pathology, Medical University of Graz, Austria.
authors.forename: Ariane
authors.initials: A
authors.lastname: Aigelsreiter
authors.forename: Tanja
authors.initials: T
authors.lastname: Gerlza
authors.forename: Alexander J A
authors.initials: AJ
authors.lastname: Deutsch
authors.forename: Eva
authors.initials: E
authors.lastname: Leitner
authors.forename: Christine
authors.initials: C
authors.lastname: Beham-Schmid
authors.forename: Alfred
authors.initials: A
authors.lastname: Beham
authors.forename: Helmut
authors.initials: H
authors.lastname: Popper
authors.forename: Nicole
authors.initials: N
authors.lastname: Borel
authors.forename: Andreas
authors.initials: A
authors.lastname: Pospischil
authors.forename: Markus
authors.initials: M
authors.lastname: Raderer
authors.forename: Harald H
authors.initials: HH
authors.lastname: Kessler
authors.forename: Peter
authors.initials: P
authors.lastname: Neumeister
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D016993:Chlamydophila pneumoniae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D002691:Chlamydophila psittaci / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000032:analysis; D005134:Eye Neoplasms / Q000382:microbiology* / Q000473:pathology; D050031:Hashimoto Disease / Q000097:blood / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D018442:Lymphoma, B-Cell, Marginal Zone / Q000097:blood / Q000382:microbiology* / Q000473:pathology; D009956:Psittacosis / Q000097:blood / Q000175:diagnosis / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D012859:Sjogren's Syndrome / Q000097:blood / Q000382:microbiology / Q000473:pathology
chemical_list: D000942:Antigens, Bacterial; D004269:DNA, Bacterial