title: [Effectiveness criteria for the topical application of glucocorticosteroids to the treatment of exudative otitis media associated with allergic rhinitis].
abstract: We undertook comparative analysis of ciliotoxic effect of glucocorticosteroids frequently used for catheterization of the eustachian tube in patients presenting with exudative otitis media and concomitant allergic rhinitis. It was shown that the recovery of transport function of ciliary epithelium and appreciable clinical effect of the treatment were achieved by the application of mometasone furoate. Dexamethasone was next to mometasone in terms of efficiency whereas hydrocortisone produced much lower beneficial effect. It is concluded that, taking into account high bioavailability of dexametasone and hydrocortisone (> 80%) and contraindications to their intranasal administration, the preference should be given to medications with lower bioavailability.
authors.forename: S D
authors.initials: SD
authors.lastname: Poliakova
authors.forename: E A
authors.initials: EA
authors.lastname: Popova
mesh_terms: D000293:Adolescent; D000328:Adult; D002404:Catheterization; D002923:Cilia / Q000187:drug effects / Q000502:physiology; D003907:Dexamethasone / Q000009:adverse effects / Q000627:therapeutic use*; D004848:Epithelium / Q000187:drug effects; D005064:Eustachian Tube; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate; D010034:Otitis Media with Effusion / Q000150:complications / Q000188:drug therapy*; D011244:Pregnadienediols / Q000009:adverse effects / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000150:complications*; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D003907:Dexamethasone; D006854:Hydrocortisone