title: Endolymphatic hydrops and blood-labyrinth barrier in Ménière's disease.
abstract: CONCLUSIONS
  The blood-labyrinth barrier is impaired in association with the hydrops grade in Ménière's disease.
  
  
  OBJECTIVE
  To investigate the relationship between endolymphatic hydrops and the clinical characteristics of patients with Ménière's disease revealed by 3 T magnetic resonance imaging (MRI).
  
  
  METHODS
  A double dose of gadoteridol (Gd; 0.2 mmol/kg) was injected intravenously in 12 patients with Ménière's disease. We performed three-dimensional fluid attenuated inversion recovery MRI and three-dimensional real inversion recovery MRI 4 h later using a 3 T MRI unit. Ten patients had unilateral and two had bilateral Ménière's disease.
  
  
  RESULTS
  Fourteen ears with Ménière's disease showed intense Gd contrast on MRI compared with that in the 10 asymptomatic contralateral ears of patients with unilateral Ménière's disease (1.12 ± 0.36 vs 0.82 ± 0.15). The hydrops grade was correlated significantly with the contrast effect. The 14 ears with Ménière's disease had endolymphatic hydrops. Of the 10 contralateral ears of patients with unilateral Ménière's disease, 2 had endolymphatic hydrops in the cochlea and 6 had endolymphatic hydrops in the vestibule.
authors.affiliation: Department of Otorhinolaryngology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, Aichi, Japan. mi-man@ra2.so-net.ne.jp
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Tagaya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Teranishi
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
authors.forename: Tadao
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hironao
authors.initials: H
authors.lastname: Otake
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nakata
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage; D007758:Ear, Inner / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005682:Gadolinium; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008575:Meniere Disease / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium