title: Preoperative administration of cephalosporins for elective caesarean delivery.
abstract: BACKGROUND
  Antibiotic prophylaxis means administration of antibiotics in prevention of infections.
  
  
  OBJECTIVE
  To investigate the efficacy of a single dose preoperative administration of ceftriaxone and cefazolin in the prevention of intra- and postoperative infections in the parturients without high risk of inflammation.
  
  
  METHODS
  The first group of 45 pregnant and 4 non-pregnant women were preoperatively administered ceftriaxone in a dose of 2 g, i.v., 10 minutes before the planned surgery. The second group of 45 pregnant and 4 non-pregnant women were preoperatively administered cefazolin in a dose of 2 g i.v., 10 minutes before the planned surgery. The concentrations of antibiotics were estimated immediately and 6 hours following the operation, as well as in the amniotic fluid and umbilical cord in the group of pregnant women. The estimation of antibiotic concentration was done by the method of liquid chromatography.
  
  
  RESULTS
  The mean concentrations of antibiotics in the patients following the elective caesarean section were as follows: ceftriaxone--22.7 microg/I. vs cefazolin--44.8 microg/l. Six hours later, the concentration of antibiotic decreased, but the concentration of cefazolin was still over the MIC for sensitive bacteria. The mean concentrations of antibiotics following gynaecological surgery in the non-pregnant patients were as follows: ceftriaxone--12.0 microg/I vs cefazolin--30.1 microg/l. Six hours later, the concentration of antibiotic decreased.
  
  
  CONCLUSIONS
  It is most optimal to administer a single-dose of the first generation cephalosporins -cefazolin- immediately following the clamping of the umbilical cord as well as in preoperative prophylaxis in gynaecological operations.
authors.affiliation: Department of Obstetrics and Gynaecology, Clinical Centre of Vojvodina, Branimira Cosića 37, 21000 Novi Sad, Serbia. zorg@neobee.net
authors.forename: Zorica
authors.initials: Z
authors.lastname: Grujić
authors.forename: Jovan
authors.initials: J
authors.lastname: Popović
authors.forename: Mirjana
authors.initials: M
authors.lastname: Bogavac
authors.forename: Ilija
authors.initials: I
authors.lastname: Grujić
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019072:Antibiotic Prophylaxis; D002511:Cephalosporins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002585:Cesarean Section; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D011247:Pregnancy
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins