title: [Clinicopathological characteristics and potential etiologies of neonatal spontaneous gastric perforation].
abstract: OBJECTIVE
  To study the etiology and clinicopathological features of neonatal spontaneous gastric perforation.
  
  
  METHODS
  The clinical data of 15 cases with neonatal gastric perforation seen from 2001 to 2009 were retrospectively analyzed. Immunohistochemical staining was adopted for all the cases.
  
  
  RESULTS
  The typical clinical manifestations of this disease were vomiting, abdominal distention and respiratory distress. Abdominal orthostatic X-ray showed free gas under diaphragm and seroperitoneum. In most of the cases the stomach perforation occurred at the greater curvature. Eight of the cases died in this group, the mortality was 53.33%. Six of the deaths occurred within 1 day after birth with symptoms. There were thinning and defect of stomach wall muscle and interstitial cells of Cajal (ICC) reduction as demonstrated by microscope.
  
  
  CONCLUSIONS
  Spontaneous neonatal gastric perforation is associated with abnormal gastric wall structure and reduction of ICC. Prognosis is closely related to the time of onset and the timely surgical operation.
authors.affiliation: Department of Pathology, Yu Ying Children's Hospital, Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Li-wei
authors.initials: LW
authors.lastname: Xie
authors.forename: Hong-fang
authors.initials: HF
authors.lastname: Wu
authors.forename: Zong-min
authors.initials: ZM
authors.lastname: Wang
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D013275:Stomach Rupture / Q000209:etiology* / Q000473:pathology*