title: Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis?
abstract: The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r(-/-)) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052 ± 601 pg/mL vs. 10,950 ± 541 pg/mL; P < .01) compared to the group receiving the high fat diet alone. There was a highly significant correlation between the plasma leptin levels and aortic atherosclerotic lesions. From this we conclude that chronic exposure to dietary Ox-LA increases the plasma levels of leptin in LDL r(-/-) mice on a high fat diet. Considering our previous finding that dietary Ox-LA increased atherosclerosis, the current findings emphasize the need to reduce dietary intake of oxidized fat.
authors.affiliation: Division of Nutrition, School of Health Professions, Georgia State University, Atlanta, Georgia, USA.
authors.forename: Meera
authors.initials: M
authors.lastname: Penumetcha
authors.forename: Nadya
authors.initials: N
authors.lastname: Merchant
authors.forename: Sampath
authors.initials: S
authors.lastname: Parthasarathy
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D050197:Atherosclerosis / Q000139:chemically induced* / Q000473:pathology*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008078:Cholesterol, LDL / Q000097:blood; D020738:Leptin / Q000097:blood*; D019787:Linoleic Acid / Q000008:administration & dosage*; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000473:pathology; D018384:Oxidative Stress; D011973:Receptors, LDL / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D020738:Leptin; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D014280:Triglycerides; D019787:Linoleic Acid