title: Replication study of SNP associations for colorectal cancer in Hong Kong Chinese.
abstract: BACKGROUND
  Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC.
  
  
  METHODS
  An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs.
  
  
  RESULTS
  Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs4779584 on 15q14 and rs12953717 on 18q21.2. There was significant linear association between CRC risk and the number of independent risk variants possessed by an individual (P=2.29 × 10(-5)).
  
  
  CONCLUSIONS
  These results indicate that some previously reported SNP associations also impact on CRC risk in the Chinese population. Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations. Our results suggest that many associations for CRC are likely to generalise across populations.
authors.affiliation: Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: J W
authors.initials: JW
authors.lastname: Ho
authors.forename: S-c
authors.initials: SC
authors.lastname: Choi
authors.forename: Y-f
authors.initials: YF
authors.lastname: Lee
authors.forename: T C
authors.initials: TC
authors.lastname: Hui
authors.forename: S S
authors.initials: SS
authors.lastname: Cherny
authors.forename: M-M
authors.initials: MM
authors.lastname: Garcia-Barceló
authors.forename: L
authors.initials: L
authors.lastname: Carvajal-Carmona
authors.forename: R
authors.initials: R
authors.lastname: Liu
authors.forename: S-h
authors.initials: SH
authors.lastname: To
authors.forename: T-k
authors.initials: TK
authors.lastname: Yau
authors.forename: C C
authors.initials: CC
authors.lastname: Chung
authors.forename: C C
authors.initials: CC
authors.lastname: Yau
authors.forename: S M
authors.initials: SM
authors.lastname: Hui
authors.forename: P Y
authors.initials: PY
authors.lastname: Lau
authors.forename: C-h
authors.initials: CH
authors.lastname: Yuen
authors.forename: Y-w
authors.initials: YW
authors.lastname: Wong
authors.forename: S
authors.initials: S
authors.lastname: Ho
authors.forename: S S
authors.initials: SS
authors.lastname: Fung
authors.forename: I P
authors.initials: IP
authors.lastname: Tomlinson
authors.forename: R S
authors.initials: RS
authors.lastname: Houlston
authors.forename: K K
authors.initials: KK
authors.lastname: Cheng
authors.forename: P C
authors.initials: PC
authors.lastname: Sham
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide