title: [Research of regulation on calcium-activated potassium channel in hypothalamic neurons by nitric oxide].
abstract: OBJECTIVE
  To study the effects of nitric oxide on calcium-activated potassium channels (KCa) in hypothalamus neurons.
  
  
  METHODS
  The data was recorded by adopting cell-attached or inside-out configuration of patch-clamp technique.
  
  
  RESULTS
  Nitric oxide was found to increase the open probability of the channels directly or through increasing cGMP, which resulted from both the prolongation of open period and increase of open frequency.
  
  
  CONCLUSIONS
  Nitric oxide could regulate calcium-activated potassium channels in hypothalamic neurons through alternative pathways.
authors.affiliation: Department of Neurosurgery, Bethune International Peaceful Hospital, Hebei, Shijiazhuang 050082, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.forename: Zhen-Gang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Zou
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology*; D009474:Neurons / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D024681:Potassium Channels, Calcium-Activated / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D024681:Potassium Channels, Calcium-Activated; D009569:Nitric Oxide; D002118:Calcium