title: Does long-course radiotherapy influence postoperative perineal morbidity after abdominoperineal resection of the rectum for cancer?
abstract: OBJECTIVE
  The aim of the study was to define risk factors for perineal wound complications after abdominoperineal resection (APR), with particular reference to preoperative radiotherapy.
  
  
  METHODS
  Patients undergoing APR at our institution between 1985 and 2009 were reviewed. Wound complications were classified according to the Center for Disease Control and Prevention classification of surgical site infection (SSI). Perineal complications were identified in patients who had preoperative long-course radiotherapy (Group 1) and those who had surgery alone (Group 2).
  
  
  RESULTS
  One hundred and fifty-seven patients met the inclusion criteria. Preoperative radiotherapy was performed in 68 (44.7%) patients (Group 1), and 89 (65.3%) patients (Group 2) underwent surgery alone. The overall rate of perineal wound complications was 14.8%. The wound infection rate was similar in each group (Group 1, 10/68, 14.7%; Group 2, 13/89, 14.9%; P = 0.9). An elevated BMI (>30) was the only factor correlated with perineal morbidity on univariate analysis (P = 0.01).
  
  
  CONCLUSIONS
  Preoperative radiotherapy does not influence perineal healing other than in patients with obesity.
authors.affiliation: Department of General Surgery, Colorectal Unit, University of Cagliari, Cagliari, Italy. gizorcolo@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Zorcolo
authors.forename: A
authors.initials: A
authors.lastname: Restivo
authors.forename: F
authors.initials: F
authors.lastname: Capra
authors.forename: G
authors.initials: G
authors.lastname: Fantola
authors.forename: L
authors.initials: L
authors.lastname: Marongiu
authors.forename: G
authors.initials: G
authors.lastname: Casula
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D010502:Perineum / Q000601:surgery; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D013529:Surgical Wound Dehiscence / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology*; D014945:Wound Healing / Q000528:radiation effects*