title: The tumor suppressor LKB1 emerges as a critical factor in hematopoietic stem cell biology.
abstract: How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling.
authors.affiliation: Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Krock
authors.forename: Nicolas
authors.initials: N
authors.lastname: Skuli
authors.forename: M Celeste
authors.initials: MC
authors.lastname: Simon