title: Hepatoid adenocarcinoma of the stomach - a rare pathological entity.
abstract: Hepatoid adenocarcinoma is a rare cancer with an extremely poor prognosis. Here, we describe two cases referred to our hospital with suspected gastric cancer. Gastrointestinal endoscopy revealed lesions in the stomach. Biopsy from the lesions was reported as adenocarcinoma. Both the patients underwent exploratory laparotomy. One was an operable lesion and the other was an inoperable lesion. Total gastrectomy was done in the operable lesion and feeding jejunostomy was done in the inoperable case. Histologically, both turned out to be hepatoid adenocarcinomas. Retrospective analysis showed the serum levels of alphafetoprotein (AFP) are markedly elevated in both cases. We describe this rare entity of hepatoid adenocarcinoma of the stomach, and review the literature concerning the clinicopathological aspects of the cases.
authors.affiliation: Division of Surgical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India. cancersurgeon@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Muralee
authors.forename: I
authors.initials: I
authors.lastname: Ahamed
authors.forename: T
authors.initials: T
authors.lastname: Somanathan
authors.forename: K S
authors.initials: KS
authors.lastname: Anila
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins