title: High antibacterial efficiency of pDMAEMA modified silicon nanowire arrays.
abstract: Materials of high antibacterial activity based on quaternized poly (2-(dimethylamino ethyl) methacrylate) (pDMAEMA) have been developed. DMAEMA was graft polymerized on silicon nanowire arrays (SiNWAs) by atom transfer radical polymerization (ATRP), and quaternized using benzyl chloride. The graft density on the modified nanowire arrays was much higher than on analogous smooth silicon, leading to higher bacterial adhesion on the nanowire arrays (34.6±0.39×10(6) vs. 5.0±0.15×10(6) cells/cm(2)). Incubation of Escherichia coli on the substrates for 18 h resulted in 95% cell death on the quaternized nanowire material compared to less than 45% on the quaternized smooth silicon. The results suggest that silicon nanowire array modified with quaternized pDMAEMA is a highly effective antibacterial material due to a high density of antibacterial polymer and consequent high bacterial adhesion and killing.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Renai Rd, , Suzhou, 215123, PR China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Pengchao
authors.initials: P
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects*; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D053770:Nanowires / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry / Q000494:pharmacology*; D012825:Silicon / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D008689:Methacrylates; D009757:Nylons; C407037:poly(2-(dimethylamino)ethyl methacrylate); D012825:Silicon