title: Phenalinolactones A-D, terpenoglycoside antibiotics from Streptomyces sp. Tü 6071.
abstract: Four new terpenoglycoside antibiotics, phenalinolactones A-D were isolated from Streptomyces sp. Tü 6071. The structures were elucidated on the basis of detailed NMR and MS analyses. Phenalinolactones combine a diterpenoid tricycle, a 2,3,6-trideoxysugar, a pyrrole-carboxylic acid and an uncommonly oxidized unsaturated γ-lactone in a unique manner. Phenalinolactones show an inhibitory activity against gram-positive bacteria.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Gebhardt
authors.forename: Sven W
authors.initials: SW
authors.lastname: Meyer
authors.forename: Jochen
authors.initials: J
authors.lastname: Schinko
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bringmann
authors.forename: Axel
authors.initials: A
authors.lastname: Zeeck
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D006027:Glycosides; D007783:Lactones; C558342:phenalinolactone A; C558343:phenalinolactone B; C558344:phenalinolactone C; C558345:phenalinolactone D