title: [Effects of stress on the cognitive function and physical fitness and its biological mechanisms].
abstract: OBJECTIVE
  To study the effects of stress on the cognitive function and physical fitness and its biological mechanisms, provide scientific basis for seeking protective measures to reduce stress-induced damage.
  
  
  METHODS
  The model of restraint stress was adopted in our experiment. Step-down test and exhaustive swimming test were used to measure the learning and memory function and physical fitness in mice, respectively. The contents of GC in plasma, hippocampus LTP, ECG, myocardial ultra-structure, cell apoptosis rate and the level of Hsp70 expression of myocardium in rats were detected.
  
  
  RESULTS
  Compared with control group, the impairment of learning and memory function and decline of exercise tolerance were observed in restraint stress group. The elevation in plasma GC levels, ECG abnonrmality, and cell apoptosis rate were also observed under restraint stress. Furthermore, myocardial structure was damaged, and myocardial Hsp70 expression and hippocampus LTP were suppressed in restraint stress group than those in the control.
  
  
  CONCLUSIONS
  Stress may cause the neuro-endocrine dysfunction and homeostasis disorder, and then, lead to the cognitive function and physical fitness damage consequently.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Fa-qing
authors.initials: FQ
authors.lastname: Yang
authors.forename: Xin-xing
authors.initials: XX
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.forename: Ling-jia
authors.initials: LJ
authors.lastname: Qian
mesh_terms: D000818:Animals; D003071:Cognition / Q000502:physiology*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006624:Hippocampus / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D010809:Physical Fitness / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D018840:HSP70 Heat-Shock Proteins