title: Chemical affinity matrix-based identification of prohibitin as a binding protein to anti-resorptive sulfonyl amidine compounds.
abstract: In order to identify the binding proteins to anti-resorptive 5-chloro-1-(2,6-dimethylpiperidin-1-yl)-N-tosylpentan-1-imine (1), the chemical affinity matrix for the compound 1 (2b) was designed and synthesized. Using 2b-based chemical proteomics, prohibitin was identified as one of strong binding proteins for 2b.
authors.affiliation: Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea.
authors.forename: Sung-Youn
authors.initials: SY
authors.lastname: Chang
authors.forename: Su Jung
authors.initials: SJ
authors.lastname: Bae
authors.forename: Myung Yun
authors.initials: MY
authors.lastname: Lee
authors.forename: Seung-Hwa
authors.initials: SH
authors.lastname: Baek
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000578:Amidines / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D050071:Bone Density Conservation Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002846:Chromatography, Affinity / Q000379:methods*; D051379:Mice; D000091402:Prohibitins; D011485:Protein Binding; D040901:Proteomics / Q000379:methods; D012097:Repressor Proteins / Q000302:isolation & purification / Q000378:metabolism*; D013441:Sulfinic Acids / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000578:Amidines; D050071:Bone Density Conservation Agents; D000091402:Prohibitins; D012097:Repressor Proteins; D013441:Sulfinic Acids