title: Concentrations of tenofovir and emtricitabine in breast milk of HIV-1-infected women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2.
abstract: The aim was to evaluate emtricitabine (FTC) and tenofovir (TFV) neonatal ingestion through breast milk. Median TFV and FTC breast milk doses represented 0.03% and 2%, respectively, of the proposed oral infant doses. Neonatal simulated plasma concentrations were extremely low for TFV but between the half-maximal inhibitory concentration and the adult minimal expected concentration for FTC. The rare children who will acquire HIV despite TDF-FTC therapy will need to be monitored for viral resistance acquisition.
authors.affiliation: Unité de Recherche Clinique, Hôpital Tarnier, 89 Rue d'Assas, 75006 Paris, France.
authors.forename: Sihem
authors.initials: S
authors.lastname: Benaboud
authors.forename: Alain
authors.initials: A
authors.lastname: Pruvost
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Coffie
authors.forename: Didier K
authors.initials: DK
authors.lastname: Ekouévi
authors.forename: Saïk
authors.initials: S
authors.lastname: Urien
authors.forename: Elise
authors.initials: E
authors.lastname: Arrivé
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
authors.forename: Frédéric
authors.initials: F
authors.lastname: Théodoro
authors.forename: Divine
authors.initials: D
authors.lastname: Avit
authors.forename: François
authors.initials: F
authors.lastname: Dabis
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Tréluyer
authors.forename: Déborah
authors.initials: D
authors.lastname: Hirt
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000032:analysis; D019380:Anti-HIV Agents / Q000032:analysis*; D007560:Cote d'Ivoire; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000032:analysis; D000068679:Emtricitabine; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry*; D063065:Organophosphonates / Q000032:analysis*; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D003841:Deoxycytidine; D000068698:Tenofovir; D000068679:Emtricitabine; D000225:Adenine