title: [Pharmacotherapy of motor manifestations in late stages of Parkinson's disease].
abstract: Accumulating data on experience of long therapy with levodopa revealed the pathomorphosis of clinical presentations of Parkinson's disease during its progression, in particular, described, the occurrence of motor fluctuations and levodopa-induced dyskinesias. In later stages of the illness, these disturbances attracted special attention of both the patient, and the attending, worsening quality of a life of patients. The article describes the main issues of the pathogenesis of this type of disorders and the currently available strategies for its treatment. We present our own experience of treatment motor fluctuations by means of the combined three-component medical product stalevo containing levodopa, carbidopa and entacapone.
authors.forename: R R
authors.initials: RR
authors.lastname: Bogdanov
authors.forename: S V
authors.initials: SV
authors.lastname: Kotov
authors.forename: A N
authors.initials: AN
authors.lastname: Kunitsyna
authors.forename: L G
authors.initials: LG
authors.lastname: Turbina
mesh_terms: D000368:Aged; D002230:Carbidopa / Q000009:adverse effects / Q000627:therapeutic use*; D002396:Catechols / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D002396:Catechols; D004338:Drug Combinations; C481098:Stalevo; D007980:Levodopa; D002230:Carbidopa