title: Anti-protozoal activity of diamine derivatives.
abstract: Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ.
authors.affiliation: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil.
authors.forename: R B
authors.initials: RB
authors.lastname: Giordani
authors.forename: D P
authors.initials: DP
authors.lastname: Araújo
authors.forename: M
authors.initials: M
authors.lastname: Duarte
authors.forename: J A
authors.initials: JA
authors.lastname: Zuanazzi
authors.forename: T
authors.initials: T
authors.lastname: Tasca
authors.forename: M V
authors.initials: MV
authors.lastname: De Almeida
mesh_terms: D000981:Antiprotozoal Agents / Q000494:pharmacology*; D003959:Diamines / Q000494:pharmacology*; D016829:Giardia lamblia / Q000187:drug effects; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D003959:Diamines