title: SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations.
abstract: Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota (DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets.
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Hälsovägen 7, S-141 83 Huddinge, Sweden. Hans.Matsson@ki.se
authors.forename: Hans
authors.initials: H
authors.lastname: Matsson
authors.forename: Kristiina
authors.initials: K
authors.lastname: Tammimies
authors.forename: Marco
authors.initials: M
authors.lastname: Zucchelli
authors.forename: Heidi
authors.initials: H
authors.lastname: Anthoni
authors.forename: Päivi
authors.initials: P
authors.lastname: Onkamo
authors.forename: Jaana
authors.initials: J
authors.lastname: Nopola-Hemmi
authors.forename: Heikki
authors.initials: H
authors.lastname: Lyytinen
authors.forename: Paavo H T
authors.initials: PH
authors.lastname: Leppanen
authors.forename: Nina
authors.initials: N
authors.lastname: Neuhoff
authors.forename: Andreas
authors.initials: A
authors.lastname: Warnke
authors.forename: Gert
authors.initials: G
authors.lastname: Schulte-Körne
authors.forename: Johannes
authors.initials: J
authors.lastname: Schumacher
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Juha
authors.initials: J
authors.lastname: Kere
authors.forename: Myriam
authors.initials: M
authors.lastname: Peyrard-Janvid
mesh_terms: D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D015331:Cohort Studies; D019852:Diacylglycerol Kinase / Q000235:genetics*; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D005387:Finland; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D005858:Germany; D006239:Haplotypes; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D019852:Diacylglycerol Kinase