title: Distribution of Chlamydia trachomatis genovars among youths and adults in Brazil.
abstract: Despite a high prevalence of sexually transmitted Chlamydia trachomatis infections in Brazil and other countries in South America, very little is known about the distribution of C. trachomatis genovars. In this study, we genotyped C. trachomatis strains from urine or endocervical specimens collected from 163 C. trachomatis-positive female and male youths, and female adults, residing in two different regions of Brazil, the city of Goiânia located in the central part of Brazil, and the city of Vitória in the south-east region. C. trachomatis strains were genotyped by amplifying and sequencing the ompA gene encoding the chlamydial major outer-membrane protein, which is genovar specific. We found nine different C. trachomatis genovars: E (39.3%), F (16.6%), D (15.9%), I (8.6%), J (7.4%), G (4.9%), K (3.1%), H (2.4%) and B (1.8%). The distribution of the C. trachomatis genovars in the two regions of Brazil was similar, and there was no statistically significant association of serovars with age, gender, number of sexual partners or clinical symptoms. The overall distribution of C. trachomatis genovars in Brazil appears similar to that found in other regions of the world, where E, D and F are the most common. This supports the notion that, during the last few decades, the overall distribution of C. trachomatis genovars throughout the world has been relatively stable.
authors.affiliation: Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Brazil.
authors.forename: Ana C S
authors.initials: ACS
authors.lastname: Machado
authors.affiliation: Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Claudiu I
authors.initials: CI
authors.lastname: Bandea
authors.affiliation: Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Brazil.
authors.forename: Maria F C
authors.initials: MFC
authors.lastname: Alves
authors.affiliation: Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Kahaliah
authors.initials: K
authors.lastname: Joseph
authors.affiliation: Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Igietseme
authors.affiliation: Nucleus of Infectious Diseases, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Angélica E
authors.initials: AE
authors.lastname: Miranda
authors.affiliation: Division of Adolescent Medicine, Department of Pediatrics, Faculty of Medicine, Federal University of Goiás, Brazil.
authors.forename: Eleuse M B
authors.initials: EMB
authors.lastname: Guimarães
authors.affiliation: Department of Community Health, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Brazil.
authors.forename: Marília D
authors.initials: MD
authors.lastname: Turchi
authors.affiliation: Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Black
mesh_terms: D000293:Adolescent; D000328:Adult; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D001938:Brazil / Q000453:epidemiology; D002584:Cervix Uteri / Q000382:microbiology; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D058889:Molecular Typing; D015995:Prevalence; D014556:Urine / Q000382:microbiology; D055815:Young Adult
chemical_list: D001425:Bacterial Outer Membrane Proteins; C078167:OMPA outer membrane proteins