title: The dual role of interleukin-25 in the control of immune-mediated pathologies.
abstract: Interleukin-25 (IL-25) plays a key role in the initiation and expansion of T helper (Th) 2 cell-mediated immune responses, thereby contributing to allergic diseases and host defense against helminthic parasites. More recent studies have however shown that IL-25 can also control the function of non-T cells, such as antigen presenting cells and endothelial cells, and reduces Th1/Th17-mediated pathologies. These new and exciting observations reveal a broader role for IL-25 than previously anticipated, and delineate various scenarios where therapeutic interventions around IL-25 activity can be imagined.
authors.affiliation: Dipartimento di Medicina Interna, Università Tor Vergata, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Caruso
authors.forename: C
authors.initials: C
authors.lastname: Stolfi
authors.forename: D
authors.initials: D
authors.lastname: De Nitto
authors.forename: F
authors.initials: F
authors.lastname: Pallone
authors.forename: G
authors.initials: G
authors.lastname: Monteleone
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000378:metabolism; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17