title: Efficacy of Cordyceps sinensis in long term treatment of renal transplant patients.
abstract: High doses of cyclosporin A (CsA) can not be used in the long term treatment of kidney allograft recipients primarily due to severe side effects. In the present study, we investigated the potential application of Cordyceps sinensis (CS) in the long term treatment of renal transplant patients. The renal function and survival rates of grafts and patients did not show significantly different between the control group and the treatment group. However, the incidences of complications were significantly lower in the treatment group compared with that in control group with the exception of those showing acute rejection. Furthermore, the dosage and the whole blood trough concentrations of CsA were significantly lower than control group. However, there was no significant difference in the serum level of IL-2 in the two groups. Interestingly, the serum level of IL-10 in the treatment group was significantly higher than that in control group. These data demonstrat that CS may be used in combination with a low dose of CsA in the long term treatment of kideny transplant patients.
authors.affiliation: Department of Renal Transplantation, the First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Ding
authors.forename: Pu-xun
authors.initials: PX
authors.lastname: Tian
authors.forename: Wujun
authors.initials: W
authors.lastname: Xue
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Ding
authors.forename: Hang
authors.initials: H
authors.lastname: Yan
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Pan
authors.forename: Xinshun
authors.initials: X
authors.lastname: Feng
authors.forename: Heli
authors.initials: H
authors.lastname: Xiang
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Tian
mesh_terms: D000328:Adult; D032661:Cordyceps / Q000737:chemistry*; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016753:Interleukin-10 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
chemical_list: D004365:Drugs, Chinese Herbal; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D016753:Interleukin-10; D016572:Cyclosporine