title: Association between tryptophan hydroxylase 2 gene polymorphism and completed suicide.
abstract: The association between suicide and a single nucleotide polymorphism (rs1386483) was examined in the recently identified tryptophan hydroxylase 2 (TPH2) gene. Blood samples of 143 suicide victims and 162 age- and sex-matched controls were examined. The frequency of the TT genotype in the TPH2 polymorphism was higher in suicide victims than in controls (17.5% vs. 8.6%; p = 0.02), particularly in those with a history of repeated suicide attempts (53.3% vs. 8.6%; p < 0.0001). The examined TPH2 polymorphism was found to be associated with suicide. This genetic marker may be particularly important in understanding risk of multiple suicide attempts. Further analyses are needed to confirm these results.
authors.affiliation: Medical University of Warsaw, Warsaw, Poland. sylwiaf@umich.edu
authors.forename: Sylwia
authors.initials: S
authors.lastname: Fudalej
authors.forename: Mark
authors.initials: M
authors.lastname: Ilgen
authors.forename: Marcin
authors.initials: M
authors.lastname: Fudalej
authors.forename: Grazyna
authors.initials: G
authors.lastname: Kostrzewa
authors.forename: Kristen
authors.initials: K
authors.lastname: Barry
authors.forename: Marcin
authors.initials: M
authors.lastname: Wojnar
authors.forename: Pawel
authors.initials: P
authors.lastname: Krajewski
authors.forename: Frederic
authors.initials: F
authors.lastname: Blow
authors.forename: Rafal
authors.initials: R
authors.lastname: Ploski
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013405:Suicide; D013406:Suicide, Attempted; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase