title: Positive correlations between tumor uptake on FDG PET and energy expenditure of patients with esophageal cancer.
abstract: OBJECTIVE
  Cancer patients are prone to clinical malnutrition; moreover, the energy expenditure in patients with certain cancers is higher than that in healthy individuals, rendering their nutritional management a challenging issue. We hypothesized that 2-deoxy-2-[(18)F]fluoro-D: -glucose (FDG) uptake on positron emission tomography (PET) may be related to the energy expenditure and analyzed the FDG uptake and energy expenditure in esophageal cancer patients to clarify this.
  
  
  METHODS
  Esophageal cancer patients [n = 13, 10 males and 3 females, age 66.5 ± 8.9 (51-82) years] were evaluated for FDG uptake using PET. The resting energy expenditure (REE) and basal energy expenditure (BEE) were calculated using indirect calorimetry and the Harris-Benedict formula, respectively. Regression analyses were performed to compare the parameters of imaging and energy expenditure.
  
  
  RESULTS
  Positive correlations were found between tumor uptake on FDG PET and the parameters of energy expenditure. Among them, the correlations between SUV(max) and the ratio of REE to BEE (REE/BEE, r = 0.59; p = 0.035) and between SUV(max) and the difference between REE and BEE (REE - BEE, r = 0.58; p = 0.036) were moderate and statistically significant. Further, the correlation between tumor uptake expressed as a percentage (%TU) and REE/BEE was mild (r = 0.51) but not significant (p = 0.07), while that between %TU and REE-BEE was weak (r = 0.42) and not significant (p = 0.15).
  
  
  CONCLUSIONS
  Significant positive correlations between SUV(max) on FDG PET and energy expenditure were noted in our study; we consider that these results may aid in determining the nutritional management for esophageal cancer patients.
authors.affiliation: Division of Advanced Surgical Science and Technology, Tohoku University, Aoba-ku, Sendai, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mitamura
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneta
authors.forename: Go
authors.initials: G
authors.lastname: Miyata
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takanami
authors.forename: Tomomichi
authors.initials: T
authors.lastname: Hiraide
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukuda
authors.forename: Shoki
authors.initials: S
authors.lastname: Takahashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Satomi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D004734:Energy Metabolism; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012146:Rest; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18