title: Left ventricular systolic strain in chronic kidney disease and hemodialysis patients.
abstract: BACKGROUND
  The impact of chronic kidney disease (CKD) and hemodialysis on heart function is not fully understood. We aimed to investigate the influence of different stages of CKD and maintenance hemodialysis on heart function.
  
  
  METHODS
  One hundred fifty-three patients were categorized into 3 subgroups [56 without CKD as controls; 37 with moderate-advanced CKD, stages 3, 4 or 5, and 60 with end-stage renal disease (ESRD) undergoing maintenance hemodialysis]. Left ventricular (LV) function was assessed by conventional echocardiography and 2-dimensional speckle-tracking echocardiography with strain analysis (2D strain analysis).
  
  
  RESULTS
  There was no significant difference of gender, age and LV ejection fraction among groups. Compared with controls, global peak systolic longitudinal strain (GS(l)), circumferential strain and strain rate were decreased in the CKD group. Along with the decline of renal function, GS(l) deteriorated. Moreover, compared with moderate-advanced CKD patients, GS(l), circumferential strain and strain rate were better in ESRD group receiving maintenance hemodialysis.
  
  
  CONCLUSIONS
  Worsening renal function was associated with a reduction of systolic function, and could be quantified by 2D strain analysis. The hemodialysis patients have better LV systolic function than the moderate-advanced CKD patients.
authors.affiliation: Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan.
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Liu
authors.forename: Chi-Ting
authors.initials: CT
authors.lastname: Su
authors.forename: Yao-Yi
authors.initials: YY
authors.lastname: Huang
authors.forename: Chun-Shin
authors.initials: CS
authors.lastname: Yang
authors.forename: Jenq-Wen
authors.initials: JW
authors.lastname: Huang
authors.forename: Mao-Ting
authors.initials: MT
authors.lastname: Yang
authors.forename: Jyh-Hong
authors.initials: JH
authors.lastname: Chen
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Tsai
mesh_terms: D000368:Aged; D002309:Cardiology / Q000379:methods; D004452:Echocardiography / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000628:therapy*; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D014682:Vena Cava, Inferior / Q000473:pathology; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000628:therapy*