title: Determination of the polar and total surface energy distributions of particulates by inverse gas chromatography.
abstract: This Letter reports a technique of measuring polar surface energy distributions of lactose using inverse gas chromatography (IGC). The significance of this study is that the total surface energy distributions can now be characterized by combining the already known dispersive surface energy distribution with polar surface energy distribution determined in this study. The polar surface energy was calculated from the specific free energies for surface interactions with a monopolar basic probe, ethyl acetate, and a monopolar acidic probe, dichloromethane.
authors.affiliation: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville campus), 381 Royal Parade, Victoria 3052, Australia. shyamal.das@monash.edu
authors.forename: Shyamal C
authors.initials: SC
authors.lastname: Das
authors.forename: Ian
authors.initials: I
authors.lastname: Larson
authors.forename: David A V
authors.initials: DA
authors.lastname: Morton
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Stewart
mesh_terms: D000085:Acetates / Q000737:chemistry; D002849:Chromatography, Gas; D007785:Lactose / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry; D010316:Particle Size; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D000085:Acetates; D008752:Methylene Chloride; C007650:ethyl acetate; D007785:Lactose