title: The efficacy, sensitivity, and specificity of strip meniscometry in conjunction with tear function tests in the assessment of tear meniscus.
abstract: OBJECTIVE
  To evaluate the specificity and sensitivity of strip meniscometry (SM) testing in conjunction with tear function tests in the diagnosis of dry eye (DE) disease and to investigate the effect of SM on reflex tearing.
  
  
  METHODS
  One hundred seven left eyes of 107 patients with definite DE disease according to the Japanese DE diagnostic criteria and 68 left eyes of 68 age- and sex-matched control subjects were studied. Tear meniscus height (TMH) measurements, fluorescein tear film break-up time (FTBUT), fluorescein (F) and rose bengal (RB) staining, and Schirmer's test-1 (ST) were also performed. The assessment of reflex tearing before and after SM application was assessed with a graticule scale at the slit lamp and by optical coherence tomography. The sensitivity and specificity of SM alone and in combination with tear function tests were also sought.
  
  
  RESULTS
  The SM scores, TMH measurements, FTBUTs, and STs were significantly lower in dry eye patients than in the controls (P < 0.001). The RB and F staining scores were significantly higher in the dry eye group than in the control group (P < 0.001). The meniscometry strips did not induce significant changes in relation to reflex tearing. SM had an acceptable sensitivity and specificity.
  
  
  CONCLUSIONS
  SM is a swift, noninvasive, promising method of assessing tear meniscus volume. The combined SM and FTBUT examination appears to be a sensitive approach to the assessment of dry eye disease.
authors.affiliation: Johnson & Johnson Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan.
authors.forename: Osama M A
authors.initials: OM
authors.lastname: Ibrahim
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Samantha K
authors.initials: SK
authors.lastname: Ward
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Tais Hitomi
authors.initials: TH
authors.lastname: Wakamatsu
authors.forename: Katsushi
authors.initials: K
authors.lastname: Ishida
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tsuyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.forename: Jun
authors.initials: J
authors.lastname: Shimazaki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007368:Interferometry; D007765:Lacrimal Apparatus / Q000378:metabolism; D008027:Light; D008297:Male; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D013666:Tears / Q000737:chemistry / Q000378:metabolism*; D041623:Tomography, Optical Coherence