title: [Leukemia stem/progenitor cells and target therapy for leukemia-- review].
abstract: Human leukemias are considered as clonal malignancies initiated at stage as early as hematopoietic stem/progenitor cells. The drug resistance and relapse are two major causes for treatment failure of leukemia. Recently, the discovery of leukemia stem/progenitor cells (LSPC) and subsequent research have provided a cue to elucidate the pathogenesis of leukemia and to explore the strategies of targeted therapy against LSPC. This review summarizes the molecular characteristics of LSPC and some research advances of therapy targeting LSPC including therapy targeting to surface molecules of LSPC, interference of interaction between LSPC and bone marrow microenvironment, regulation mechanisms of some specific molecular and so on.
authors.affiliation: Department of Hematology, Southeast University Medical College, Nanjing 210009, Jiangsu Province, China.
authors.forename: Tian-Tian
authors.initials: TT
authors.lastname: Wang
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Chen
mesh_terms: D006801:Humans; D007938:Leukemia / Q000628:therapy*; D014411:Neoplastic Stem Cells; D033581:Stem Cell Transplantation