title: Effect of non-surgical periodontal treatment on chronic kidney disease patients.
abstract: Chronic kidney disease (CKD) is a debilitating systemic condition. Our working hypothesis is that CKD predialysis patients with periodontitis would respond poorly to periodontal treatment owing to immunologic compromise. Twenty-one predialysis patients (group 1) and 19 individuals without clinical evidence of kidney disease (group 2) with chronic periodontitis were subjected to non-surgical periodontal treatment with no antibiotics. Clinical periodontal and systemic parameters were evaluated at baseline and 3 months after treatment. Both groups showed significant and similar post-treatment improvements in all periodontal parameters examined. Most interestingly, periodontal treatment had a statistically significant positive effect on the glomerular filtration rate of each individual (group 1, p = 0.04; group 2, p = 0.002). Our results indicate that chronic periodontitis in predialysis kidney disease patients improved similarly in patients with chronic periodontitis and no history of CKD after receiving non-surgical periodontal therapy. This study demonstrates that CKD predialysis patients show a good response to non-surgical periodontal treatment.
authors.affiliation: Department of Dental Clinic, Federal University of Rio de Janeiro, RJ, Brazil. hilanartese@gmail.com
authors.forename: Hilana Paula Carillo
authors.initials: HP
authors.lastname: Artese
authors.forename: Celso Oliveira de
authors.initials: CO
authors.lastname: Sousa
authors.forename: Ronir Raggio
authors.initials: RR
authors.lastname: Luiz
authors.forename: Carmelo
authors.initials: C
authors.lastname: Sansone
authors.forename: Maria Cynésia Medeiros de Barros
authors.initials: MC
authors.lastname: Torres
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D055113:Chronic Periodontitis / Q000628:therapy*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D018709:Statistics, Nonparametric; D016896:Treatment Outcome