title: Association study of PDE4B with panic disorder in the Japanese population.
abstract: BACKGROUND
  Panic disorder (PD) is a severe and chronic psychiatric disorder with genetic components underlying in its etiology. The Phosphodiesterase 4B (PDE4B) gene has been reported to be associated with several psychiatric disorders. Several studies indicated that PDE4B may be involved in the regulation of anxiety and depression. Therefore, we investigate the association of PDE4B with PD in the Japanese population.
  
  
  METHODS
  We genotyped 14 single nucleotide polymorphisms (SNPs) of PDE4B in 231 PD cases (85 males and 146 females) and 407 controls (162 males and 245 females). Differences in the genotype, allele and haplotype frequencies between the two groups were compared.
  
  
  RESULTS
  We found a significant association between PDE4B and PD in the haplotype analysis (haplotype C-T-T-A, permutation P=0.031, OR=1.81, 95% CI=1.30-2.51). Sex-specific analyses demonstrated that PDE4B was associated with PD in females in the allele/genotype and haplotype analyses (rs10454453, allele P=0.042, genotype P=0.0034; haplotype C-T-T-A, permutation P=0.028).
  
  
  CONCLUSIONS
  Our results suggest that PDE4B may play a role in the pathophysiology of PD in the Japanese population. Replication studies using larger samples will be needed for more reliable conclusions.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan. totowa@vcu.edu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Nagisa
authors.initials: N
authors.lastname: Sugaya
authors.forename: Eiji
authors.initials: E
authors.lastname: Yoshida
authors.forename: Takafumi
authors.initials: T
authors.lastname: Shimada
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Liu
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Taku
authors.initials: T
authors.lastname: Miyagawa
authors.forename: Nao
authors.initials: N
authors.lastname: Nishida
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Kaiya
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000483:Alleles; D001008:Anxiety Disorders / Q000235:genetics; D044466:Asian People / Q000235:genetics; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000235:genetics* / Q000502:physiology; D003863:Depression / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D016584:Panic Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D020641:Polymorphism, Single Nucleotide; D012727:Sex Characteristics
chemical_list: D054703:Cyclic Nucleotide Phosphodiesterases, Type 4