title: Computed tomography reflected endocrine function of the pancreas.
abstract: BACKGROUNS/AIMS: There are few studies about the assessment of pancreatic function using computed tomography (CT) volumetry. In this study, we examined the correlation between CT volumetry and endocrine parameters (blood glucose and HbA1c) of the pancreas.
  
  
  METHODS
  A total of 68 patients underwent enhanced CT for pancreatic disease from January to December in 2008. In particular, we analyzed the correlation of diabetic status and pancreatic CT parameters at 1 year after pancreatoduodenectomy in 32 patients. CT parameters including volume, volume/body weight, arterial phase density, the arterial phase to portal phase density ratio (A/P ratio) of the pancreas, and size of pancreatic duct were also analyzed. Correlation between CT parameters and diabetic status was analyzed preoperatively and postoperatively by ANOVA test.
  
  
  RESULTS
  The preoperative diabetic status and parameters correlated well with arterial phase density (p = 0.004), A/P ratio, and pancreatic duct size (p < 0.0001). In the patients who underwent pancreatectomy, two out of 25 patients without preoperative diabetes mellitus (DM) had DM, and two out of seven patients with preoperative DM recovered from DM. Postoperative CT parameters correlated with the DM status 1 year after pancreatectomy.
  
  
  CONCLUSIONS
  CT is a useful modality for evaluation of the pancreatic endocrine function and could be used for the prediction of postoperative diabetic outcome.
authors.affiliation: Division of Hepato-Biliary Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. n-sakata@surg1.med.tohoku.ac.jp
authors.forename: Naoaki
authors.initials: N
authors.lastname: Sakata
authors.forename: Shinichi
authors.initials: S
authors.lastname: Egawa
authors.forename: Toshiki
authors.initials: T
authors.lastname: Rikiyama
authors.forename: Gumpei
authors.initials: G
authors.lastname: Yoshimatsu
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Masuda
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohtsuka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ottomo
authors.forename: Kei
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Takanori
authors.initials: T
authors.lastname: Morikawa
authors.forename: Tohru
authors.initials: T
authors.lastname: Onogawa
authors.forename: Kuniharu
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Masanori
authors.initials: M
authors.lastname: Akada
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Motoi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Naitoh
authors.forename: Yu
authors.initials: Y
authors.lastname: Katayose
authors.forename: Michiaki
authors.initials: M
authors.lastname: Unno
mesh_terms: D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003920:Diabetes Mellitus / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D021621:Imaging, Three-Dimensional; D009929:Organ Size; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D016577:Pancreaticoduodenectomy / Q000009:adverse effects; D057234:Preoperative Period; D012372:ROC Curve; D014057:Tomography, X-Ray Computed
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human