title: Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus.
abstract: The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA.
authors.affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S102TN, UK.
authors.forename: Gethin
authors.initials: G
authors.lastname: Allen
authors.forename: Mike
authors.initials: M
authors.lastname: Bromley
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Kaye
authors.forename: David
authors.initials: D
authors.lastname: Keszenman-Pereyra
authors.forename: Tiago D
authors.initials: TD
authors.lastname: Zucchi
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Price
authors.forename: Mike
authors.initials: M
authors.lastname: Birch
authors.forename: Jason D
authors.initials: JD
authors.lastname: Oliver
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Turner
mesh_terms: D000213:Acyl Carrier Protein / Q000378:metabolism; D001232:Aspergillus fumigatus / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D050296:Microbial Viability; D008928:Mitochondria / Q000201:enzymology*; D013379:Substrate Specificity; D017855:Transferases (Other Substituted Phosphate Groups) / Q000235:genetics / Q000378:metabolism*
chemical_list: D000213:Acyl Carrier Protein; D001426:Bacterial Proteins; C082662:phosphopantetheinyl transferase; D017855:Transferases (Other Substituted Phosphate Groups)