title: [The protect effect of ischemic preconditioning on the gastric mucosal injury following ischemia/reperfusion of hind limbs of rats].
abstract: OBJECTIVE
  To observe the degree of gastric mucosal injury following limb ischemia/reperfusion (LI/R), and to investigate the mechanism of gastric mucosal injury and the protection of ischemic preconditioning (IPC) on gastric mucosal injury.
  
  
  METHODS
  The model rats which underwent 4 hours of ischemia and 4 hours of reperfusion of hind limbs were made. Then we respectively observed and determined the histologic lesion score after I/R and IPC + I/R. The gastric barrier mucus in mucus were measured in different groups. The values of MPO, SOD, MDA and XOD in gastric mucosa and the values of MDA, XOD, SOD, LDH in plasma were detected.
  
  
  RESULTS
  In the LI/R group, the histologic lesion score increased significantly. The content of gastric barrier mucus in mucus decreased significantly. The value of MPO, MDA, XOD in gastric mucosa and the values of MDA, XOD, LDH in plasma increased remarkably and SOD activity in gastric mucosa and in plasma decreased. However in the IPC group, the histologic lesion score decreased significantly and the content of gastric barrier mucus in mucus increased significantly and the value of MPO MDA XOD LDH in gastric mucosa or in plasma decreased remarkably and the SOD activity increased compared to LI/R group.
  
  
  CONCLUSIONS
  LI/R will lead to the development of stress ulcer, oxygen free radicals play an important role in it. IPC can alleviate the damage of gastric mucosa following ischemia/reperfusion of hind limbs. The decrease of OFR is one of the protection mechanism of IPC.
authors.affiliation: Department of Pathophysiology, North China Coal Medical Collage, Tangshan 063000, China.
authors.forename: Rui-Li
authors.initials: RL
authors.lastname: Yao
authors.forename: Lian-Yuan
authors.initials: LY
authors.lastname: Zhang
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Men
authors.forename: Shu-Yun
authors.initials: SY
authors.lastname: Dong
authors.forename: Quan-Hui
authors.initials: QH
authors.lastname: Yang
mesh_terms: D000818:Animals; D005121:Extremities / Q000098:blood supply; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D019194:Ischemic Preconditioning; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology*