title: [Hereditary complement deficiency in Tunisian adults with purulent meningitis].
abstract: Inherited complement deficiency is a rare disease. It predisposes to autoimmune diseases, glomerulonephritis, angioedema, and meningococcal meningitis. A prospective study was conducted over five years. The goal was to evaluate the prevalence of deficiency in Tunisian patients presenting with community acquired purulent meningitis and identify the type of deficiency. We enrolled 122 patients, 15 of whom presented with a complement deficiency (12.3%). This prevalence was higher than the one observed in the global Tunisian population and in reported international data. The mean age of deficient patients (13 men and two women) was 24.7 years.
authors.affiliation: Service des maladies infectieuses, hôpital La Rabta, Jebari, Tunis, Tunisia. rimabdelmalek@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Abdelmalek
authors.forename: M
authors.initials: M
authors.lastname: Kallel Sallemi
authors.forename: Y
authors.initials: Y
authors.lastname: Zerzri
authors.forename: B
authors.initials: B
authors.lastname: Kilani
authors.forename: L
authors.initials: L
authors.lastname: Laadhar
authors.forename: F
authors.initials: F
authors.lastname: Kanoun
authors.forename: H
authors.initials: H
authors.lastname: Tiouiri Benaissa
authors.forename: A
authors.initials: A
authors.lastname: Ghoubantini
authors.forename: L
authors.initials: L
authors.lastname: Ammari
authors.forename: S
authors.initials: S
authors.lastname: Makni
authors.forename: T
authors.initials: T
authors.lastname: Ben Chaabane
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017714:Community-Acquired Infections / Q000097:blood / Q000150:complications / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis / Q000172:deficiency* / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D016920:Meningitis, Bacterial / Q000097:blood / Q000150:complications* / Q000276:immunology; D008590:Meningoencephalitis / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D003165:Complement System Proteins