title: [Effects of zinc on the free radical signals and apoptosis in liver with ischemia/ reperfusion injury].
abstract: OBJECTIVE
  In order to explore the preventive mechanism of zinc, the changes of free radical signals and apoptosis in hepatic ischemia/reperfusion injury (HIR) rats were observed.
  
  
  METHODS
  The MDA levels in serum were measured by fluorophotometry, free radical signals in liver were analyzed with electron spin resonance (ESR) method; and apoptosis was assayed by flow cytometry (FCM).
  
  
  RESULTS
  MDA levels in serum and free radical contents in liver were both increased in rats with HIR. After zinc supplementation, they were decreased. After HIR, the percentage of subdiploid cells was 57.72% while it was reduced to 40.85% after zinc supplementation.
  
  
  CONCLUSIONS
  Zinc may protect against HIR injury by inhibiting the production of free radicals in liver and hepatocellular apoptosis.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Jiang
authors.forename: C J
authors.initials: CJ
authors.lastname: Guo
authors.forename: J Y
authors.initials: JY
authors.lastname: Wei
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005609:Free Radicals / Q000378:metabolism*; D007511:Ischemia / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology; D015032:Zinc / Q000494:pharmacology*
chemical_list: D005609:Free Radicals; D015032:Zinc