title: Method of gene delivery in large animal models of cardiovascular diseases.
abstract: Cardiovascular disease is a major cause of morbidity and mortality in contemporary societies. While progress in conventional treatment modalities is making steady and incremental gains to reduce this disease burden, there remains a need to explore new and potentially therapeutic approaches. Gene therapy, which was initially envisioned as a treatment strategy for inherited monogenic disorders, has been found to hold broader potential that also includes acquired polygenic diseases, such as atherosclerosis, arrhythmias, and heart failure. Advances in the understanding of the molecular basis of conditions such as these, together with the evolution of increasingly efficient gene transfer technology, have placed some cardiovascular pathophysiologies within the reach of gene-based therapy. In fact, gene therapy holds great promise as a targeted treatment for cardiovascular diseases. One of the major hurdles for effective cardiovascular gene therapy is the delivery of the viral vectors to the heart. In this chapter, we will present the various types of delivery techniques in preclinical, large animal models of cardiovascular diseases.
authors.affiliation: The Cardiovascular Research Center, Mount Sinai School of Medicine, Atran Berg Laboratory Building, Floor 05, 1428 Madison Avenue, New York, NY, USA.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawase
authors.forename: Dennis
authors.initials: D
authors.lastname: Ladage
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Hajjar
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization; D006348:Cardiac Surgical Procedures / Q000379:methods; D002318:Cardiovascular Diseases / Q000235:genetics / Q000628:therapy*; D000229:Dependovirus / Q000235:genetics; D004195:Disease Models, Animal; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D007267:Injections; D008863:Microspheres