title: Evaluation of endothelial function and effect of glycemic control (excellent vs. poor / fair control) on endothelial function in uncontrolled type 2 diabetes mellitus.
abstract: OBJECTIVE
  To evaluate the endothelial functions before and after glycemic control in type II diabetes mellitus.
  
  
  METHODS
  It was an open, randomized and comparative study on 30 patients of type 2 diabetes mellitus. The study was of 12 weeks spread over 5 visits. The initial visit (visit 1) is for screening of patients. Other visits (visits 2 to 5) constituted the follow up of patients. The primary efficacy parameters included blood sugar (fasting and postprandial) done on each visit and glycosylated hemoglobin (HbA1c) done at visits 1 and 5. Based on glycosylated hemoglobin (HbA1c) only poorly controlled and fairly controlled patients were included in the study. Brachial artery flow mediated vasodilatation (FMD) was studied in all these patient at visits 1 and 5 to see the effect of glycemic control on endothelial functions. Results obtained were statistically analyzed with appropriate method.
  
  
  RESULTS
  There was a significant improvement in endothelial functions in patients with fair, good and excellent control of diabetes. During uncontrolled state (HbA1c 10.08 +/- 0.48%) FMD was lowest, i.e., 2.88 +/- 0.53 at 1st week which improved to 11.94 +/- 3.33 at 12th week with control of diabetes (HbA1c 6.74 +/- 0.16%). The FMD in patients who had fair control (HbAlc 8.45 +/- 0.30%) in the beginning was 6.74 +/- 2.43% and after excellent control in these patients FMD rises to 12.81 +/- 3.16%.
  
  
  CONCLUSIONS
  Our data showed that the endothelial functions improved sequentially with control of diabetes from fair to good to excellent glycemic control.
authors.affiliation: Department of Medicine, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak & Pt. B. D. Sharma University of Health Sciences, Rohtak, Haryana, India.
authors.forename: S N
authors.initials: SN
authors.lastname: Chugh
authors.forename: Surekha
authors.initials: S
authors.lastname: Dabla
authors.forename: Vinish
authors.initials: V
authors.lastname: Jain
authors.forename: Kiran
authors.initials: K
authors.lastname: Chugh
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Sen
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D001916:Brachial Artery / Q000502:physiology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005215:Fasting; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D019518:Postprandial Period; D012931:Social Environment; D014664:Vasodilation / Q000502:physiology
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents