title: [The protection of vitamin E on LTP in hippocampal dentate gyrus of rats under stress].
abstract: OBJECTIVE
  To study the effects of vitamin E on stress-induced impairments in hippocampus of rats.
  
  
  METHODS
  Twenty four male Wistar rats were randomly allocated into four groups: control, stress, control+ VE, stress+ VE. The rat stress model was built by restraining for 6 h/d,21 d. The long-term potentiation was induced in rat hippocampal dentate gyrus (DG) by high-frequency test stimulation.
  
  
  RESULTS
  Compared with control group, the rats suffered from restraint stress showed that the number of crossing in open-field test and the content of glucocorticoids in plasma was significantly increased, the changes of amplitude of population spike (PS) were significantly lower. After VE supplementation in stress rats, the indices mentioned above were significantly improved.
  
  
  CONCLUSIONS
  Opportune supplementation of vitamin E may improve the brain function under stress.
authors.affiliation: Institue of Health and Environmental Medicine, Tianjin 300050, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hong
authors.forename: Yi-Yong
authors.initials: YY
authors.lastname: Cheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D014810:Vitamin E