title: Effects of porcine MC4R and LEPR polymorphisms, gender and Duroc sire line on economic traits in Duroc × Iberian crossbred pigs.
abstract: Polymorphisms MC4R c.1426 A>G (p.Asp298Asn) and LEPR c.2002 C>T (p.Leu663Phe) have been associated in pigs with feed intake, growth and fatness. Our aims were to analyze how these polymorphisms influence production and quality traits in Duroc × Iberian crossbred pigs, and moreover evaluate how the effects of gender and Duroc line were affecting these traits. Significant effects of gender, Duroc sire line and LEPR c.2002 C>T mutation, were detected on the main traits. LEPR c.2002 T allele increased body weight (2.5 ± 0.7 kg), backfat thickness (1.5 ± 0.4mm), loin intramuscular fat (0.7 ± 0.2 %), and lightness (1.0 ± 0.3); however it was decreasing premium cuts yield (-0.9 ± 0.2%). Allele c.2002 T increased SFA (0.60 ± 0.12 %), and decreased MUFA (-0.35 ± 0.12%) and PUFA (-0.25 ± 0.06%). No significant effects of MC4R c.1426 A>G SNP were identified. A genetic test based on the LEPR c.2002 C>T SNP may be useful to select Duroc sires to reduce undesirable heterogeneity of carcasses and premium cuts of crossbred animals.
authors.affiliation: Departamento de Mejora Genética Animal, INIA, Ctra. Coruña Km 7, 28040 Madrid, Spain. munoz.gloria@inia.es
authors.forename: G
authors.initials: G
authors.lastname: Muñoz
authors.forename: E
authors.initials: E
authors.lastname: Alcázar
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.forename: C
authors.initials: C
authors.lastname: Barragán
authors.forename: A
authors.initials: A
authors.lastname: Carrasco
authors.forename: E
authors.initials: E
authors.lastname: de Pedro
authors.forename: L
authors.initials: L
authors.lastname: Silió
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez
authors.forename: M C
authors.initials: MC
authors.lastname: Rodríguez
mesh_terms: D000483:Alleles; D000818:Animals; D001823:Body Composition; D001835:Body Weight; D003433:Crosses, Genetic; D005260:Female; D005838:Genotype; D008297:Male; D008460:Meat; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D054411:Receptors, Leptin / Q000235:genetics*; D012737:Sex Factors; D013552:Swine / Q000235:genetics*
chemical_list: D054411:Receptors, Leptin