title: Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the phosphatidylinositol-3-OH kinase (PI-3K) / Akt pathway.
abstract: Activation of Akt by insulin is transmitted via phosphatidylinositol-3-OH kinase (PI-3K) and enhances glucose uptake. The PI-3K/Akt signaling is diminished in insulin resistance. Thus, approaches that activate PI-3K/Akt signaling leading to improved glucose uptake may ameliorate hyperglycemia. Here we showed that low-intensity electrical current or mild electrical stimulation (MES) activated the PI-3K/Akt signaling and increased the glucose uptake in rat skeletal muscle (L6) cells. The glucose uptake enhanced by MES in muscle cells, the major cells involved in glucose disposal, suggests MES may have a possible beneficial effect on hyperglycemia.
authors.affiliation: Department of Molecular Medicine, Kumamoto University, Japan.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Yano
authors.forename: Saori
authors.initials: S
authors.lastname: Morino-Koga
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kondo
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Suico
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Koga
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Shimauchi
authors.forename: Shingo
authors.initials: S
authors.lastname: Matsuyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shuto
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Eiichi
authors.initials: E
authors.lastname: Araki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kai
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004558:Electric Stimulation; D005947:Glucose / Q000378:metabolism*; D006943:Hyperglycemia / Q000628:therapy; D007328:Insulin / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction
chemical_list: D007328:Insulin; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D005947:Glucose