title: Serial pediatric symptom checklist screening in children with prenatal drug exposure.
abstract: OBJECTIVE
  To examine screening results obtained by serial annual behavioral assessment of children with prenatal drug exposure.
  
  
  METHODS
  The Maternal Lifestyle Study enrolled children with prenatal cocaine exposure (PCE) at birth for longitudinal assessments of developmental, behavioral, and health outcomes. At 8, 9, 10, 11, and 12 years of age, caregivers rated participants on the Pediatric Symptom Checklist (PSC). Serial PSC results were compared with an established broad-based behavioral measure at 9, 11, and 13 years. PSC results were analyzed for 1081 children who had at least 2 annual screens during the 5-year time span. Most subjects (87%) had 4 or more annual screens rated by the same caregiver (80%). PSC scores (and Positive screens) over time were compared at different time points for those with and without PCE. Covariates, including demographic factors and exposures to certain other substances, were controlled.
  
  
  RESULTS
  Children with PCE had significantly higher scores overall, with more Positive screens for behavior problems than children without PCE. Children with PCE had more externalizing behavior problems. Children exposed to tobacco prenatally and postnatally also showed higher PSC scores. Over time, PSC scores differed slightly from the 8-year scores, without clear directional trend. Earlier PSC results predicted later behavioral outcomes.
  
  
  CONCLUSIONS
  Findings of increased total PSC scores and Positive PSC screens for behavioral concerns in this group of children with prenatal substance exposure support the growing body of evidence that additional attention to identification of mental health problems may be warranted in this high-risk group.
authors.affiliation: Department of Pediatrics, Boling Center for Developmental Disabilities, University of Tennessee College of Medicine, Memphis, TN 38105, USA. twhitaker@uthsc.edu
authors.forename: Toni M
authors.initials: TM
authors.lastname: Whitaker
authors.forename: Henrietta S
authors.initials: HS
authors.lastname: Bada
authors.forename: Carla M
authors.initials: CM
authors.lastname: Bann
authors.forename: Seetha
authors.initials: S
authors.lastname: Shankaran
authors.forename: Linda
authors.initials: L
authors.lastname: LaGasse
authors.forename: Barry M
authors.initials: BM
authors.lastname: Lester
authors.forename: Charles R
authors.initials: CR
authors.lastname: Bauer
authors.forename: Jane
authors.initials: J
authors.lastname: Hammond
authors.forename: Rosemary
authors.initials: R
authors.lastname: Higgins
mesh_terms: D000293:Adolescent; D000367:Age Factors; D017028:Caregivers; D057189:Checklist / Q000379:methods; D002648:Child; D002653:Child Behavior Disorders / Q000139:chemically induced* / Q000175:diagnosis* / Q000523:psychology; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000175:diagnosis*; D012307:Risk Factors; D011795:Surveys and Questionnaires / Q000592:standards
chemical_list: D003042:Cocaine