title: An enyne cycloisomerization approach to the triple reuptake inhibitor GSK1360707F.
abstract: The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of this work such as the choice of the nitrogen protecting group and initial enantioselectivity studies are discussed.
authors.affiliation: Chemical Development, GlaxoSmithKline, 5 Moore Dr., Research Triangle Park, North Carolina 27709, United States.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Deschamps
authors.forename: Vassil I
authors.initials: VI
authors.lastname: Elitzin
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Mark B
authors.initials: MB
authors.lastname: Mitchell
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Sharp
authors.forename: Elie A
authors.initials: EA
authors.lastname: Tabet
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D053961:Azabicyclo Compounds; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014179:Neurotransmitter Uptake Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D010984:Platinum / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C557997:1-(3,4-dichlorophenyl)-6-(methoxymethyl)-4-azabicyclo(4.1.0)heptane; D000480:Alkynes; D053961:Azabicyclo Compounds; D006574:Heterocyclic Compounds, 2-Ring; D014179:Neurotransmitter Uptake Inhibitors; D010984:Platinum; D006046:Gold