title: Long-term effects of neonatal glutamine-enriched nutrition in very-low-birth-weight infants.
abstract: Several studies in very-low-birth-weight (VLBW) infants have investigated the effect of parenteral or enteral glutamine supplementation on morbidity, mortality, and outcome in the neonatal period. No evidence of toxicity of glutamine supplementation was found in these clinical trials, but the results for efficacy on a limited number of outcomes have been mixed. The use of glutamine supplementation in VLBW infants has not become routine. Some authors suggest that further study in this area is no longer warranted. In this review, more recent research in the area of glutamine supplementation is described, which suggests additional studies are warranted.
authors.affiliation: Division of Neonatology, Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Annelies
authors.initials: A
authors.lastname: van Zwol
authors.forename: Josef
authors.initials: J
authors.lastname: Neu
authors.forename: Ruurd M
authors.initials: RM
authors.lastname: van Elburg
mesh_terms: D004750:Enteral Nutrition; D005973:Glutamine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology*; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D010288:Parenteral Nutrition; D016896:Treatment Outcome
chemical_list: D005973:Glutamine