title: Effect of selected accelerants on setting time and biocompatibility of mineral trioxide aggregate (MTA).
abstract: OBJECTIVE
  Various additives have been suggested to be used with mineral trioxide aggregate (MTA) to improve its handling characteristics. The purpose of this study was to evaluate the effects of various additives on setting time and cell attachment on gray MTA (GMTA).
  
  
  METHODS
  Single-rooted caries-free teeth were split, and dentin disks with class I cavity were made and filled with test and control materials. Setting time was measured using Gilmore apparatus. Mouse MC3T3-E1 osteoblasts and L929 mouse fibroblasts were grown on dentin and GMTA disks. Cell attachment was examined under fluorescent microscope.
  
  
  RESULTS
  Adding KY liquid, CaCl(2), and NaOCl to GMTA improved the handling properties and decreased setting time. Osteoblasts and fibroblasts attached and spread on GMTA mixed with additives in a manner similar to GMTA mixed with water.
  
  
  CONCLUSIONS
  The various additives could be possible substitutes to water to decrease MTA setting time. MTA is biocompatible when mixed with the various additives.
authors.affiliation: Division of Endodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030-1715, USA.
authors.forename: Amer Z
authors.initials: AZ
authors.lastname: AlAnezi
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.forename: Yu-Hsiung
authors.initials: YH
authors.lastname: Wang
authors.forename: Kamran E
authors.initials: KE
authors.lastname: Safavi
authors.forename: Jin
authors.initials: J
authors.lastname: Jiang
mesh_terms: D016475:3T3 Cells; D017607:Aluminum Compounds / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D017610:Calcium Compounds / Q000737:chemistry*; D002448:Cell Adhesion / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D003804:Dentin; D004338:Drug Combinations; D004339:Drug Compounding; D005347:Fibroblasts / Q000187:drug effects; D005990:Glycerol / Q000494:pharmacology; D007739:L Cells; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects; D010087:Oxides / Q000737:chemistry*; D010710:Phosphates / Q000494:pharmacology; D011409:Propylene Glycols / Q000494:pharmacology; D012387:Root Canal Filling Materials / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry*; D012973:Sodium Hypochlorite / Q000494:pharmacology; D013997:Time Factors
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D017610:Calcium Compounds; D004338:Drug Combinations; C042973:K-Y jelly; D010087:Oxides; D010710:Phosphates; D011409:Propylene Glycols; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D002482:Cellulose; D012973:Sodium Hypochlorite; D002122:Calcium Chloride; D005990:Glycerol