title: PUGSVM: a caBIG™ analytical tool for multiclass gene selection and predictive classification.
abstract: Phenotypic Up-regulated Gene Support Vector Machine (PUGSVM) is a cancer Biomedical Informatics Grid (caBIG™) analytical tool for multiclass gene selection and classification. PUGSVM addresses the problem of imbalanced class separability, small sample size and high gene space dimensionality, where multiclass gene markers are defined by the union of one-versus-everyone phenotypic upregulated genes, and used by a well-matched one-versus-rest support vector machine. PUGSVM provides a simple yet more accurate strategy to identify statistically reproducible mechanistic marker genes for characterization of heterogeneous diseases.
  
  
  BACKGROUND
  http://www.cbil.ece.vt.edu/caBIG-PUGSVM.htm.
authors.affiliation: Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Huai
authors.initials: H
authors.lastname: Li
authors.forename: Sook
authors.initials: S
authors.lastname: Ha
authors.forename: Ie-Ming
authors.initials: IeM
authors.lastname: Shih
authors.forename: Robert
authors.initials: R
authors.lastname: Clarke
authors.forename: Eric P
authors.initials: EP
authors.lastname: Hoffman
authors.forename: Subha
authors.initials: S
authors.lastname: Madhavan
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xuan
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D020869:Gene Expression Profiling; D052138:Genes, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000145:classification / Q000235:genetics*; D010641:Phenotype; D012984:Software