title: [Relationship of Chinese medicine syndrome pattern with heart function and brain natriuretic peptide in patients with heart failure].
abstract: OBJECTIVE
  To observe the relationship of Chinese medicine (CM) syndrome pattern with heart function detected by ultrasonic cardiography and brain natriuretic peptide (BNP) level in patients with heart failure (HF).
  
  
  METHODS
  One hundred and sixteen inpatients of HF hospitalized in Dongfang Hospital from January, 2007 to January, 2009 were assigned to three groups according to their CM syndrome pattern differentiated, the qi-yin deficiency group (QYD), the qi-deficiency and blood-stasis group (QDBS) and the yang-deficiency with water overflowing group (YDWO). Ultrasonic cardiographic (USCG) parameters, including left ventricular end-systolic diameter (LVEDs), left ventricular end-diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) were detected, and blood level of BNP was measured.
  
  
  RESULTS
  LVEF was decreased while BNP was increased in patients with syndrome patterns in the order of QYD --> QDBS --> YDWO, and showed significant difference between groups (P < 0.01); CM syndrome patterns was related with all the USCG parameters and BNP level, especially the BNP (r = 0.71, P < 0.05) and LVEF (r = -0.34, P < 0.05).
  
  
  CONCLUSIONS
  LVEF and BNP can reflect the severity of heart failure, and they could be taken as the beneficial objective and quantitative indices for syndrome pattern differentiation.
authors.affiliation: Department of Cardiology, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing. lihui8832@163.com
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Shu-Yun
authors.initials: SY
authors.lastname: Xie
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D013318:Stroke Volume / Q000502:physiology; D014463:Ultrasonography; D016276:Ventricular Function / Q000502:physiology*; D055815:Young Adult
chemical_list: D020097:Natriuretic Peptide, Brain