title: Altered blood flow distribution in the rat spinal cord under chronic compression.
abstract: METHODS
  Sham-operation-controlled animal study to assess alterations in blood flow in the spinal cord in a chronic compression model. Laboratory investigation.
  
  
  OBJECTIVE
  Cervical myelopathy is a common cause of disability in elderly patients. Hypothesis was made that ischemia subsequent to the spinal cord compression plays an important role in the pathogenesis of the spinal cord dysfunction. This study was undertaken to assess alterations in the blood flow of the spinal cord under chronic compression in a rat model.
  
  
  BACKGROUND
  Histologic study of spinal cord from patients with spondylotic myelopathy showed ischemic tissue changes. Experimentally, spinal cord hypoperfusion in combination with chronic spinal cord compression induced myelopathy in dogs. We previously showed that chronic compression of the spinal cord in rats produces gradual deterioration of mobility of the animals accompanied by cord tissue degeneration compatible with ischemic changes.
  
  
  METHODS
  Chronic compression of the cervical spinal cord was implemented by implantation of a thin urethane polymer sheet under the C5-C6 laminae, which expands by absorbing tissue water over 48-72 hours. The control group underwent sham operation. Twelve weeks later, blood flow to the C3-C4 and C5-C6 spinal cord segments were measured by fluorescent microsphere methods.
  
  
  RESULTS
  In the control group, the blood flow in the C5-C6 segment was larger than C3-C4 segment. In the compression group, the blood flow in the C5-C6 was significantly reduced compared to the C3-C4 segment.
  
  
  CONCLUSIONS
  Under chronic focal spinal cord compression, there was a decrease of the blood flow in the compressed segment in comparison to the rostral segment. Our data are compatible with the hypothesis that alteration in the spinal cord blood flow contributes to pathogenesis of myelopathy.
authors.affiliation: Department of Neurologic Surgery, Dokkyo University, Japan.
authors.forename: Ryu
authors.initials: R
authors.lastname: Kurokawa
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Murata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ogino
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ueki
authors.forename: Phyo
authors.initials: P
authors.lastname: Kim
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002574:Cervical Vertebrae / Q000601:surgery; D004195:Disease Models, Animal; D015536:Down-Regulation; D005456:Fluorescent Dyes / Q000008:administration & dosage; D007267:Injections; D008297:Male; D008863:Microspheres; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D013050:Spectrometry, Fluorescence; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology; D013117:Spinal Cord Compression / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D020760:Spinal Cord Ischemia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D005456:Fluorescent Dyes