title: UNCovering the molecular machinery of dependence receptor signaling.
abstract: Dependence receptors send opposite signals in the presence or absence of ligand, but the underlying mechanisms have been elusive. In this issue of Molecular Cell, Guenebeaud et al. (2010) elucidate the molecular signaling machinery of the dependence receptor UNC5B.
authors.affiliation: Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Bagri
authors.forename: Avi
authors.initials: A
authors.lastname: Ashkenazi