title: [Efficacy and securyty of therapeutic hypothermia for hypoxic ischemic encephalopathy: a meta-analysis].
abstract: BACKGROUND
  Animal and human experimental models suggest that therapeutic hypothermia could reduce neurological disabilities in asphyxiated newborn without adverse events. The objective of this study was review the effectiveness and safety of hypothermia as treatment for hypoxic ischemic encephalophaty.
  
  
  METHODS
  MEDLINE, COCHRANE LIBRARY, Academic Google and LILACS databases were searched. Randomized controlled trials with main outcomes of death, neurodevelopmental disability and adverse events were eligible for inclusion in the meta-analysis.
  
  
  RESULTS
  Tree studies were included with 751 patients. Combined results of death reduction was not significant (RR 0.83 CI95% 0.67 to 1.04). Severe to moderate neurodevelopmental disability (RR 0.70 CI95% 0.55 to 0.89) and cerebral palsy (RR 0.66 CI95% 0.50 to 0.89) were reduced significantly in newborns receiving hypothermia compared with controls. Cardiac arrhythmias (RR 3.51 CI95% 1.29 to 9.54) and coagulation disorders (RR 1,23 CI95% 1.03 a 1.48) were more common adverse events with hypothermia.
  
  
  CONCLUSIONS
  Hypothermia is effective in reducing neurological disability and cerebral palsy. Cardiac arrhythmias and coagulation disorders were more common with hypothermia, however they were clinically benign.
authors.affiliation: Servicio de Pediatría y Neonatología Hospital Privado Centro Médico de Córdoba, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Rizzotti
authors.forename: José
authors.initials: J
authors.lastname: Bas
authors.forename: Eduardo
authors.initials: E
authors.lastname: Cuestas
mesh_terms: D002658:Developmental Disabilities / Q000517:prevention & control; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000401:mortality / Q000628:therapy*; D007231:Infant, Newborn; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D016896:Treatment Outcome