title: Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine.
abstract: Intramuscular vaccination may lead to loss of subcutaneous fat resulting in skin depression at the site of injection. We report for the first time a delayed lipoatrophy after with AS03-adjuvanted influenza A (H1N1) 2009 vaccine. Inadequate administration into the adipose tissue may be causative. During next pandemic, education to optimal intramuscular administration and prolonged monitoring of adverse effects could be proposed.
authors.affiliation: Department of Infectious Diseases and Tropical Medicine, Laveran Military Teaching Hospital, Marseille Cedex 13, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Javelle
authors.forename: Benjamin
authors.initials: B
authors.lastname: Soulier
authors.forename: Christian
authors.initials: C
authors.lastname: Brosset
authors.forename: Solène
authors.initials: S
authors.lastname: Lorcy
authors.forename: Fabrice
authors.initials: F
authors.lastname: Simon
mesh_terms: D000328:Adult; D004338:Drug Combinations; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D007273:Injections, Intramuscular; D008060:Lipodystrophy / Q000139:chemically induced* / Q000473:pathology; D011136:Polysorbates / Q000008:administration & dosage / Q000009:adverse effects*; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D013185:Squalene / Q000008:administration & dosage / Q000009:adverse effects*; D040521:Subcutaneous Tissue / Q000473:pathology; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D004338:Drug Combinations; D007252:Influenza Vaccines; D011136:Polysorbates; D013185:Squalene; C550253:AS03 adjuvant; D024502:alpha-Tocopherol