title: Serum uric acid is inversely related to acute ischemic stroke morbidity in hemodialysis patients.
abstract: OBJECTIVE
  Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population. The aim of this study is to evaluate the role of sUA in AIS among hemodialysis (HD) patients.
  
  
  METHODS
  We followed up the occurrence of AIS in 226 HD patients for 18 months from January 2009 to June 2010. The parameters included demographic characteristics, duration of HD, sUA, serum albumin, and other parameters. Logistic regression was performed to evaluate the function of SUC levels in the occurrence of AIS.
  
  
  RESULTS
  A total of 43 patients suffered from AIS. By univariate logistic regression analysis an inverse association was observed in sUA level with the risk of AIS (p = 0.005), but the significance of this inverse association was attenuated while adjusted for age, gender and pulse pressure (PP) (p = 0.029), and even weakened while adjusted for age, gender, PP and diabetes nephropathy (DN) (p = 0.065), and finally abolished after adjustment for age, gender, PP, DN, hsCRP and pre-albumin.
  
  
  CONCLUSIONS
  This study indicates an inverse association between sUC and the occurrence of AIS in HD patients. Demographic characteristics and malnutrition-microinflammation syndrome seem to play a significant role in this association.
authors.affiliation: Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Yuemei
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Teng
authors.forename: Jianzhou
authors.initials: J
authors.lastname: Zou
authors.forename: Yihong
authors.initials: Y
authors.lastname: Zhong
authors.forename: Yi
authors.initials: Y
authors.lastname: Fang
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Liu
authors.forename: Shaowei
authors.initials: S
authors.lastname: Xu
authors.forename: Yimei
authors.initials: Y
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002545:Brain Ischemia / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012044:Regression Analysis; D006435:Renal Dialysis / Q000379:methods*; D012737:Sex Factors; D020521:Stroke / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid