title: The impact of inflammation on bone mass in children.
abstract: Bone is a dynamic tissue. Skeletal bone integrity is maintained through bone modeling and remodeling. The mechanisms underlying this bone mass regulation are complex and interrelated. An imbalance in the regulation of bone remodeling through bone resorption and bone formation results in bone loss. Chronic inflammation influences bone mass regulation. Inflammation-related bone disorders share many common mechanisms of bone loss. These mechanisms are ultimately mediated through the uncoupling of bone remodeling. Cachexia, physical inactivity, pro-inflammatory cytokines, as well as iatrogenic factors related to effects of immunosuppression are some of the common mechanisms. Recently, cytokine signaling through the central nervous system has been investigated for its potential role in bone mass dysregulation in inflammatory conditions. Growing research on the molecular mechanisms involved in inflammation-induced bone loss may lead to more selective therapeutic targeting of these pathological signaling pathways.
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, Mail Code 0634, La Jolla, CA 92093-0634, USA.
authors.forename: Wai W
authors.initials: WW
authors.lastname: Cheung
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Zhan
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Paik
authors.forename: Robert H
authors.initials: RH
authors.lastname: Mak
mesh_terms: D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000503:physiopathology; D015398:Signal Transduction / Q000276:immunology*