title: Chemical priming for spinal cord injury: a review of the literature part II-potential therapeutics.
abstract: BACKGROUND
  Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of "arousal" towards better function. Priming can be mechanical as trauma is known to enhance activity in cells.
  
  
  METHODS
  A comprehensive review of the literature was performed to better understand the possible chemical primers used for spinal cord injuries.
  
  
  CONCLUSIONS
  Taken together, many studies have shown various promising results using the substances outlined herein for treating SCI.
authors.affiliation: Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AR, USA.
authors.forename: Martin M
authors.initials: MM
authors.lastname: Mortazavi
authors.forename: Ketan
authors.initials: K
authors.lastname: Verma
authors.forename: Aman
authors.initials: A
authors.lastname: Deep
authors.forename: Fatemeh B
authors.initials: FB
authors.lastname: Esfahani
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Pritchard
authors.forename: R Shane
authors.initials: RS
authors.lastname: Tubbs
authors.forename: Nicholas
authors.initials: N
authors.lastname: Theodore
mesh_terms: D000818:Animals; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D009414:Nerve Growth Factors