title: Synthesis of a Benzodiazepine-derived Rhodium NHC Complex by C-H Bond Activation.
abstract: The synthesis and characterization of a Rh(I)-NHC complex generated by C-H activation of 1,4-benzodiazepine heterocycle are reported. This complex constitutes a rare example of a carbene tautomer of a 1,4-benzodiazepine aldimine stabilized by transition metal coordination and demonstrates the ability of the catalytically relevant RhCl(PCy(3))(2) fragment to induce NHC-forming tautomerization of heterocycles possessing a single carbene-stabilizing heteroatom. Implications for the synthesis of benzodiazepines and related pharmacophores via C-H functionalization are discussed.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Gribble
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ellman
authors.forename: Robert G
authors.initials: RG
authors.lastname: Bergman