title: Role and impact of carbapenem in nosocomial infections.
abstract: Although carbapenem antibiotics are one of the most effective agents in the treatment of nosocomial infections caused by Gram-negative bacteria, their use is threatened by the emergence of antibiotic resistance. The bacterial resistance to carbapenems parallels their increasing use and has dramatic clinical implications such as increase in mortality and cost of care. This article reviews recently published patents claiming for carbapenem antibacterial agents. New forms including crystalline forms with high oral bioavailability and modified spectrum including methicillin-resistant Staphylococci are some of new patents described in this review.
authors.affiliation: Department of Internal Medicine, Beaujon Hospital, 100 Boulevard du Général Leclerc, 92110 Clichy, France.
authors.forename: T M
authors.initials: TM
authors.lastname: Goulenok
authors.forename: Kamel
authors.initials: K
authors.lastname: Majed
authors.forename: Mehran
authors.initials: M
authors.lastname: Monchi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015780:Carbapenems / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004304:Dosage Forms; D004352:Drug Resistance, Microbial; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D010330:Patents as Topic
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004304:Dosage Forms