title: The role of pramipexole in a severe Parkinson's disease model in mice.
abstract: BACKGROUND
  Pramipexole is one of a new generation of dopamine agonists. Recently there have been questions regarding its neuroprotective effects. These effects have been tested against various insults, which have yielded conflicting results.
  
  
  METHODS
  In this study, we introduced a combination of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/paraquat to induce a severe Parkinson's disease model. The mice, after receiving the combination of toxins, were evaluated using mortality rates and immunohistochemistry for degenerating tyrosine hydroxylase-positive neurons.
  
  
  CONCLUSIONS
  Pramipexole was tested for its capacity to offer protection against neurotoxic the effects of MPTP/paraquat in this model; however, the results showed no improvement with pramipexole therapy.
authors.affiliation: Toxicology Department, Mansoura University, Mansoura, Egypt.
authors.forename: Seham Gad
authors.initials: SG
authors.lastname: Elhak
authors.forename: Abdel Aziz
authors.initials: AA
authors.lastname: Ghanem
authors.forename: Hasan
authors.initials: H
authors.lastname: Abdelghaffar
authors.forename: Sahar
authors.initials: S
authors.lastname: Eldakroury
authors.forename: Dina
authors.initials: D
authors.lastname: Eltantawy
authors.forename: Sara
authors.initials: S
authors.lastname: Eldosouky
authors.forename: Mohamed
authors.initials: M
authors.lastname: Salama