title: [Microdialysis and HPLC method for determination of concentration of pantoprazole in rat striatum aftercombined administration with borneol].
abstract: OBJECTIVE
  To observe the influence of borneol, a traditional Chinese medicine, on the concentration of ceftriaxone in the rat brain striatum and evaluate the relativity.
  
  
  METHODS
  The sample of cerebrospinal fluid in the rat brain striatum was collected via brain microdialysis technology, and then the contents of ceftriaxone in standard preparation and sample were detected by high efficiency liquid chromatography combined with diode array detector respectively and analyzed statistically. The concentration of ceftriaxone in rat brain striatum in the ceftriaxone + Borneol group was compared with that in the ceftriaxone-only group.
  
  
  RESULTS
  The concentration of ceftriaxone in the rat brain in the ceftriaxone + Borneol group (13.01-4.43 mg x L(-1)) is significantly higher than that in the ceftriaxone-only group (2.41-0.94 mg x L(-1)).
  
  
  CONCLUSIONS
  Borneol can promote ceftriaxone through blood-brain barrier, and increase the concentration thereof in striatum.
authors.affiliation: Outpatient Pharmacy of PLA General Hospital, Beijing 100853, China. w4244@sina.com
authors.forename: Yuning
authors.initials: Y
authors.lastname: Wei
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Xinrong
authors.initials: X
authors.lastname: He
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000493:pharmacokinetics*; D000818:Animals; D001812:Blood-Brain Barrier; D001892:Camphanes / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004338:Drug Combinations; D008297:Male; D008516:Medicine, Chinese Traditional; D017551:Microdialysis; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D000077402:Pantoprazole; D051381:Rats; D017208:Rats, Wistar
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001892:Camphanes; D004338:Drug Combinations; D002443:Ceftriaxone; D000077402:Pantoprazole; C022871:isoborneol