title: Effects of peroxisome proliferator activated receptor-gamma 2 gene Pro12Ala polymorphism on fasting blood lipids: a meta-analysis.
abstract: OBJECTIVE
  Results from the published studies on the association of peroxisome proliferator activated receptor-gamma 2 (PPARγ2) Pro12Ala polymorphism with blood lipids are conflicting. In this meta-analysis, we investigated the association of the Pro12Ala polymorphism with total cholesterol, triglycerides, low density lipoprotein cholesterol, and high-density lipoprotein cholesterol.
  
  
  METHODS
  74 studies with 52,998 subjects were included in this meta-analysis. Dominant model and additive model were used for this meta-analysis.
  
  
  RESULTS
  We did not detect significant overall association of the Pro12Ala polymorphism with total cholesterol, low density lipoprotein cholesterol, or high-density lipoprotein cholesterol (P>0.05). Under dominant model, significant association between the PPARγ2 Pro12Ala polymorphism and increased blood TC in male subjects was detected: standardized mean difference=0.10, 95% confidence interval (0.02, 0.22), P=0.02, Pheterogeneity=0.14. We found a marginal association of the Pro12Ala polymorphism with increased HDL-C in healthy subjects under dominant model: standardized mean difference=0.10, 95% confidence interval (-0.00, 0.20), P=0.06, Pheterogeneity=0.96. We also found subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians: for analysis including the outlier studies: SMD=-0.40, 95% CI (-0.76, -0.05), P=0.02, Pheterogeneity<0.00001, and for analysis excluding the outlier studies: SMD=-0.23, 95% CI (-0.39, -0.06), P=0.006, Pheterogeneity=0.86.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that, compared with non-carriers, carriers of Ala allele have significant increased blood TC in male subjects, and marginally significant increased blood HDL-C in healthy subjects. Our meta-analysis also supports that subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians.
authors.affiliation: College of Life Sciences, Zhejiang University, and Department of GEriatrics, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310000, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Huang
authors.forename: Jiangpei
authors.initials: J
authors.lastname: Zhao
authors.forename: Tongfeng
authors.initials: T
authors.lastname: Zhao
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005215:Fasting / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood; D044465:White People / Q000235:genetics
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D047495:PPAR gamma; D014280:Triglycerides; D002784:Cholesterol