title: Eating disorders in adolescents: correlations between symptoms and central control of eating behavior.
abstract: The aim of this study was to verify the relationship between eating disorders (binge eating and bulimia nervosa) and body image dissatisfaction with BMI, anorexigenic and orexigenic factors in adolescents. Thirty-two adolescents, (13 obese [BMI=36.65±5.68] and 19 non-obese [BMI=22.18±3.11]), aged between 14 and 19y, were recruited. Symptoms of eating disorders were measured by self-report questionnaires (BSQ, BITE and BES). Hormones, cytokines and neuropeptides were determined by Elisa kits (Phoenix peptide). A positive correlation was found between: leptin and BES (r=.724), BSQ (r=.705) and BITE (r=.696); BMI and BES (r=.663), BSQ (r=.525) and BITE (r=.732); the same pattern was observed to insulin and TNF-α. A negative correlation was found in α-MSH and AgRP with BES, BSQ and BITE. Blood levels of hormones and neuropeptides could be the link between obesity and eating disorders in adolescents. However, it is not clear which is the cause and which is the consequence.
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo, Paulista Medicine School--UNIFESP-EPM, São Paulo/SP, Brazil. maralofrano@gmail.com
authors.forename: Mara Cristina
authors.initials: MC
authors.lastname: Lofrano-Prado
authors.forename: Wagner Luiz do
authors.initials: WL
authors.lastname: Prado
authors.forename: Aline
authors.initials: A
authors.lastname: de Piano
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.forename: Danielle Arisa
authors.initials: DA
authors.lastname: Caranti
authors.forename: Claudia Maria Oller do
authors.initials: CM
authors.lastname: Nascimento
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Marco Túlio
authors.initials: MT
authors.lastname: de Mello
authors.forename: Ana Raimunda
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D000293:Adolescent; D054369:Agouti-Related Protein / Q000097:blood; D000856:Anorexia Nervosa; D001828:Body Image; D015992:Body Mass Index; D002032:Bulimia / Q000523:psychology*; D052018:Bulimia Nervosa / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D009765:Obesity / Q000523:psychology; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult; D000521:alpha-MSH / Q000097:blood
chemical_list: C515198:AGRP protein, human; D054369:Agouti-Related Protein; D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D000521:alpha-MSH