title: Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.
abstract: The placenta plays an important role as a regulator of fetal nutrition and growth throughout development and placental factors contribute to gestational abnormalities such as preeclampsia. This study describes the genome-wide gene expression profiles of a large (n = 60) set of human placentas in order to uncover gene expression patterns associated with preeclampsia. In addition to confirming changes in expression of soluble factors associated with preeclampsia such as sFLT1 (soluble fms-like tyrosine kinase-1), sENG (soluble endoglin), and INHA (inhibin alpha), we also find changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeclampsia. Notably, we also find evidence of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases.
authors.affiliation: Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
authors.forename: S
authors.initials: S
authors.lastname: Tsai
authors.forename: N E
authors.initials: NE
authors.lastname: Hardison
authors.forename: A H
authors.initials: AH
authors.lastname: James
authors.forename: A A
authors.initials: AA
authors.lastname: Motsinger-Reif
authors.forename: S R
authors.initials: SR
authors.lastname: Bischoff
authors.forename: B H
authors.initials: BH
authors.lastname: Thames
authors.forename: J A
authors.initials: JA
authors.lastname: Piedrahita
mesh_terms: D000115:Acetylesterase / Q000096:biosynthesis*; D015703:Antigens, CD / Q000096:biosynthesis; D000071063:Endoglin; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D007231:Infant, Newborn; D007265:Inhibins / Q000096:biosynthesis; D008297:Male; D011225:Pre-Eclampsia / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D040081:Protein Array Analysis; D011956:Receptors, Cell Surface / Q000096:biosynthesis; D014327:Trophoblasts / Q000502:physiology; D015854:Up-Regulation; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000096:biosynthesis*
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; C094377:inhibin-alpha subunit; D007265:Inhibins; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1; D000115:Acetylesterase; C046298:sialate O-acetylesterase