title: [Treatment effects of electroacupuncture on gentamycin ototoxicity and its mechanism in guinea pigs].
abstract: OBJECTIVE
  To investigate the effects of electroacupuncture on gentamycin (GE) ototoxicity in guinea pigs.
  
  
  METHODS
  Brainstem auditory evoked potential (BAEP) and histochemistry were used in our study.
  
  
  RESULTS
  Electroacupuncture reduced the elevated BAEP thresholds and shortened the prolongated BAEP wave latencies and interpeak latencies. It protected the activity of mitochondrial enzyme in the cochlear hair cells and cochlear stria vascularis.
  
  
  CONCLUSIONS
  Electroacupuncture therapy can reduce GE ototoxicity. The mechanism of electroacupuncture therapy may be associated with its protected activity of mitochondrial enzyme and maintenance of energy metabolism of the cochlear hair cells and cochlear stria vascularis.
authors.affiliation: Department of Physiology, Taishan Medical College, Taian 271000, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Kang
authors.forename: X J
authors.initials: XJ
authors.lastname: Shi
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Shi
authors.forename: Z L
authors.initials: ZL
authors.lastname: Zeng
mesh_terms: D000818:Animals; D015671:Electroacupuncture; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects*; D008297:Male; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D005839:Gentamicins; D013385:Succinate Dehydrogenase