title: Interaction of cationic liposomes with cell membrane models.
abstract: The interaction of phosphatidylcholine liposomes used as cell models, with cationic liposomes formulated with 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine and amphiphiles based on a pyrrolidinium headgroup was investigated by differential scanning calorimetry and fluorescence resonance energy transfer experiments. The results obtained showed that subtle variations in the formulation can influence lipid interactions and were correlated to a previous biological evaluation.
authors.affiliation: Dipartimento di Ingegneria Chimica, dei Materiali, delle Materie Prime e dell'Ambiente, Università degli Studi di Roma Sapienza, P.le A. Moro 5, 00185 Roma, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bonicelli
authors.forename: Luisa
authors.initials: L
authors.lastname: Giansanti
authors.forename: Marco
authors.initials: M
authors.lastname: Ierino
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mancini
mesh_terms: D002152:Calorimetry, Differential Scanning; D002412:Cations / Q000737:chemistry / Q000378:metabolism; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry / Q000378:metabolism*; D004735:Energy Transfer; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism*; D011759:Pyrrolidines / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
chemical_list: D002412:Cations; D008081:Liposomes; D010713:Phosphatidylcholines; D011759:Pyrrolidines; D004134:Dimyristoylphosphatidylcholine