title: The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy.
abstract: This study was conducted by the Japanese Society of Chemotherapy and is the first nationwide study on bacterial pathogens isolated from patients with urinary tract infections at 28 hospitals throughout Japan between January 2008 and June 2008. A total of 688 bacterial strains were isolated from adult patients with urinary tract infections. The strains investigated in this study are as follows: Enterococcus faecalis (n = 140), Escherichia coli (n = 255), Klebsiella pneumoniae (n = 93), Proteus mirabilis (n = 42), Serratia marcescens (n = 44), and Pseudomonas aeruginosa (n = 114). The minimum inhibitory concentrations of 39 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. All Enterococcus faecalis strains were susceptible to ampicillin and vancomycin. Although a majority of the E. faecalis strains were susceptible to linezolid, 11 strains (7.8%) were found to be intermediately resistant. The proportions of fluoroquinolone-resistant Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and S. marcescens strains were 35.7%, 29.3%, 18.3%, and 15.2%, respectively. The proportions of E. coli, P. mirabilis, K. pneumoniae, and S. marcescens strains producing extended-spectrum β-lactamase were 5.1%, 11.9%, 0%, and 0%, respectively. The proportions of Pseudomonas aeruginosa strains resistant to carbapenems, aminoglycosides, and fluoroquinolones were 9.2%, 4.4%, and 34.8%, respectively, and among them, 2 strains (1.8%) were found to be multidrug resistant. These data present important information for the proper treatment of urinary tract infections and will serve as a useful reference for periodic surveillance studies in the future.
authors.affiliation: Japanese Society of Chemotherapy (JSC), Nichinai Kaikan B1, Tokyo, Japan. karyo@jc4.so-net.ne.jp
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yasuda
authors.forename: Shinya
authors.initials: S
authors.lastname: Uehara
authors.forename: Tetsuro
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authors.lastname: Muratani
authors.forename: Morimasa
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authors.lastname: Yagisawa
authors.forename: Junko
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authors.lastname: Sato
authors.forename: Yoshihito
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authors.lastname: Niki
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Totsuka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hanaki
authors.forename: Rikizo
authors.initials: R
authors.lastname: Hattori
authors.forename: Michinori
authors.initials: M
authors.lastname: Terada
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Kozuki
authors.forename: Akinori
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authors.lastname: Maruo
authors.forename: Kohei
authors.initials: K
authors.lastname: Morita
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Yoshisaburo
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuda
authors.forename: Takaoki
authors.initials: T
authors.lastname: Hirose
authors.forename: Noriomi
authors.initials: N
authors.lastname: Miyao
authors.forename: Tasuku
authors.initials: T
authors.lastname: Hayashi
authors.forename: Koh
authors.initials: K
authors.lastname: Takeyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyota
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tomita
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yusu
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Koide
authors.forename: Shoji
authors.initials: S
authors.lastname: Kimura
authors.forename: Masanori
authors.initials: M
authors.lastname: Yanaoka
authors.forename: Hajime
authors.initials: H
authors.lastname: Sato
authors.forename: Toru
authors.initials: T
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Deguchi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Hisao
authors.initials: H
authors.lastname: Komeda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Asano
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishihara
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Nakano
authors.forename: Kazushi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsui
authors.forename: Akira
authors.initials: A
authors.lastname: Fujii
authors.forename: Shingo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Michio
authors.initials: M
authors.lastname: Nojima
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Higuchi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ueda
authors.forename: Sojun
authors.initials: S
authors.lastname: Kanamaru
authors.forename: Koichi
authors.initials: K
authors.lastname: Monden
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Tsushima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Seno
authors.forename: Masaya
authors.initials: M
authors.lastname: Tsugawa
authors.forename: Tadasu
authors.initials: T
authors.lastname: Takenaka
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Hamasuna
authors.forename: Naohiro
authors.initials: N
authors.lastname: Fujimoto
authors.forename: Takehiko
authors.initials: T
authors.lastname: Sho
authors.forename: Koichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Hisato
authors.initials: H
authors.lastname: Inatomi
authors.forename: Naoya
authors.initials: N
authors.lastname: Takahashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ikei
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayami
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamane
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Kariya
authors.forename: Takashi
authors.initials: T
authors.lastname: Arima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D013293:Enterococcus faecalis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012958:Societies, Scientific; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents