title: Serum ischemia-modified albumin levels in an experimental acute mesenteric ischemia model.
abstract: OBJECTIVE
  This experimental study aimed to assess the changes in the levels of serum ischemia-modified albumin (IMA) and interleukin-6 (IL-6) by time in cases of acute mesenteric ischemia due to superior mesenteric artery occlusion.
  
  
  METHODS
  Twenty-one New Zealand rabbits were randomly divided into three groups. Blood samples were collected at hours 0, 1, 3, and 6 from animals in a control group; a sham group following a simple laparotomy; and in an ischemia group following superior mesenteric artery ligation. All blood samples were analyzed for serum IMA and IL-6 levels, and then the time-dependent changes of biomarkers were investigated.
  
  
  RESULTS
  The serum IMA levels of the ischemia group at hours 3 and 6 were significantly higher than those of the control and sham groups (hour 3, p = 0.017; hour 6, p = 0.001). The increase in serum IL-6 levels in the ischemia group at hours 1, 3, and 6 compared to the control and sham groups was also significant (hour 1, p = 0.002; hour 3, p = 0.003; hour 6, p = 0.003).
  
  
  CONCLUSIONS
  IMA may be helpful as a marker in the diagnosis of acute mesenteric ischemia; however, its diagnostic value and use as a routine biochemical test should be assessed in further studies.
authors.affiliation: Emergency Medicine Department, Selcuk University, Konya, Turkey. zerdef@hotmail.com
authors.forename: Zerrin Defne
authors.initials: ZD
authors.lastname: Dundar
authors.forename: Basar
authors.initials: B
authors.lastname: Cander
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gul
authors.forename: Keziban Ucar
authors.initials: KU
authors.lastname: Karabulut
authors.forename: Sadik
authors.initials: S
authors.lastname: Girisgin
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D005260:Female; D015850:Interleukin-6 / Q000097:blood*; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000097:blood*; D008638:Mesenteric Arteries / Q000473:pathology; D008641:Mesenteric Vascular Occlusion; D009092:Mucous Membrane / Q000473:pathology; D011817:Rabbits; D011897:Random Allocation; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D012709:Serum Albumin