title: [Herbal drug-drug interaction and adverse drug reactions].
abstract: Herbal medicines are used by many patients. Their known or potential adverse events should be taken into account during treatment with herbal medicines. In this article adverse effects of commonly used herbs are presented. St. John's wort is known to be a potent inducer of cytochrome P450 (CYP) 3A4 leading to reduced blood concentrations of a number of CYP3A4 substrates. For many other combinations evidence is sparse but due to a number of case reports of adverse interactions they should only cautiously be combined with certain critical dose drugs until their risk is fully assessed. Pertinent examples are the immunostimulant Echinacea which could decrease the effect of immunosuppressants. Ginseng and ginkgo should not be combined with anticoagulants. Excessive sedation may occur with concomitant use of valerian and barbiturates.
authors.affiliation: Abteilung Klinische Pharmakologie und Pharmakoepidemiologie, Medizinische Klinik, Universitätsklinikum Heidelberg. verena.hafner@med.uni-heidelberg.de
authors.forename: Verena
authors.initials: V
authors.lastname: Hafner-Blumenstiel
mesh_terms: D051544:Cytochrome P-450 CYP3A / Q000187:drug effects; D020900:Echinacea / Q000633:toxicity; D004790:Enzyme Induction; D020441:Ginkgo biloba / Q000633:toxicity; D041743:Herb-Drug Interactions; D006801:Humans; D020902:Hypericum / Q000633:toxicity; D005894:Panax / Q000633:toxicity; D008517:Phytotherapy / Q000009:adverse effects*; D010936:Plant Extracts / Q000633:toxicity; D028321:Plant Preparations / Q000633:toxicity*; D014632:Valerian / Q000633:toxicity
chemical_list: D010936:Plant Extracts; D028321:Plant Preparations; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human