title: [Diffuse brown discoloration of skin, mucosa and urine].
abstract: A 45-year-old woman presented with diffuse melanosis, icteric sclera and melanuria. Physical examination revealed a massive nodular melanoma with ulceration and satellite metastases on the back. Further investigation showed distant cutaneous and visceral metastasis. After palliative debulking along with postoperative multidrug chemotherapy, the patient has shown objective disease regression for more than 11 months. However, it remains to be seen if disease regression will translate into increased survival.
authors.affiliation: Fachklinik Hornheide, Dorbaumstr. 300, 48157, Münster. Christian.Hallermann@Fachklinik-Hornheide.de
authors.forename: C
authors.initials: C
authors.lastname: Hallermann
authors.forename: H-J
authors.initials: HJ
authors.lastname: Schulze
mesh_terms: D005260:Female; D006801:Humans; D008543:Melanins / Q000652:urine; D008545:Melanoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy / Q000652:urine*; D008548:Melanosis / Q000175:diagnosis / Q000209:etiology* / Q000652:urine; D008875:Middle Aged; D012074:Remission Induction; D015422:Scleral Diseases / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
chemical_list: D008543:Melanins