title: The role of photodynamic therapy for hilar cholangiocarcinoma.
abstract: The prognosis for hilar cholangiocarcinoma is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses results in median survival times of 4-6 months for advanced bile duct cancer. Photodynamic therapy (PDT) is a local photochemical tumor treatment consisting of a photosensitizing agent combined with laser irradiation of a distinct wavelength. Tumor ablation with PDT combined with biliary stenting reduces cholestasis and significantly improves median survival time. However, the treatment is not widely available, and the photosensitizers used for PDT cause prolonged photosensitivity. Optimum control of tumor spread along the bile ducts and control of cholestasis and cholangitis will prolong survival in one to two thirds of patients, and renders them suitable for other antitumor therapies.
authors.affiliation: Institute for Digestive Research and Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, Korea. yksky001@hanmail.net
authors.forename: Young Koog
authors.initials: YK
authors.lastname: Cheon
mesh_terms: D001650:Bile Duct Neoplasms / Q000188:drug therapy*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000188:drug therapy*; D006801:Humans; D010778:Photochemotherapy; D016896:Treatment Outcome