title: Thermal FT-IR microspectroscopy for rapid detection of solid-state ion-exchange reaction between metoclopramide HCl monohydrate and potassium bromide.
abstract: The combination of Fourier transform infrared (FT-IR) microspectroscopy with a thermal analyzer was applied to quickly investigate the solid-state ion-exchange reaction of metoclopramide HCl monohydrate (MCP H(2)O) by clipping MCP H(2)O powder between two KBr or KCl pellets. The physical and ground mixtures of MCP H(2)O or 150 °C-preheated MCP powder and KBr or KCl powders with a weight ratio of 1 : 100 were also prepared and determined by FT-IR microspectroscopy. The samples of MCP H(2)O or 150 °C-preheated MCP were identified by using differential scanning calorimetry (DSC) and thermogravimetric (TG) analysis. The results of present study indicate that the ion-exchange reaction was easily induced between MCP H(2)O and KBr by grinding and heating processes. The possible mechanism of ion-exchange reaction may take place between the HCl salt of MCP H(2)O and a KBr matrix by grinding or heating to yield a mixture of HCl and HBr salts of the MCP sample in the presence of hydrated water. The crystal hydrate played an important role to improve this ion-exchange reaction between MCP H(2)O and KBr. However, no ion-exchange reaction occurred between MCP H(2)O and KCl or between 150 °C-preheated MCP and KBr. The solid-state ion-exchange reaction was more easily determined by this novel thermal FT-IR microspectroscopy than other conventional methods.
authors.affiliation: Lab. Pharm. Biopharm., Department of Biotechnology, Yuanpei University, Hsin Chu, Taiwan, Republic of China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Cheng
authors.forename: Shun-Li
authors.initials: SL
authors.lastname: Wang
authors.forename: Shan-Yang
authors.initials: SY
authors.lastname: Lin
mesh_terms: D001965:Bromides / Q000032:analysis*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D006358:Hot Temperature; D007474:Ion Exchange; D008787:Metoclopramide / Q000032:analysis*; D017680:Potassium Compounds / Q000032:analysis*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D001965:Bromides; D017680:Potassium Compounds; D008787:Metoclopramide; C039004:potassium bromide