title: Nitric oxide: a key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2.
abstract: Diabetes mellitus type-2 (DM-2) contributes to atherogenesis by inducing endothelial cell injury and dysfunction. Endothelial progenitor cells (EPCs) are essential to blood vessel formation, can differentiate into mature endothelial cells, and promote the repair of damaged endothelium. In DM-2, the circulating EPC count is low and their functionality is impaired. The mechanisms that underlie this reduced count and impaired functionality are poorly understood. Nitric oxide (NO) is a short-lived signalling molecule that is produced by vascular endothelial cells and participates in the maintenance of vascular tone. NO is also known to participate in other physiological processes, such as cell survival, proliferation, and migration. The bioavailability of NO is reduced in EPCs from DM-2 patients. Interestingly, an inverse relationship exists between the reduction in NO bioavailability in EPCs and the patient's plasma glucose and glycated haemoglobin levels. In addition, NO bioavailability in EPCs correlates with plasma oxidized low-density lipoprotein levels in DM-2. Although this reduction in NO bioavailability could be attributed to oxidative stress in DM-2 patients, it also may be due to impairment of one or more members of the protein signalling cascades that are responsible for NO production. The stimulation of NO production or its signalling cascades in EPCs may increase their numbers and improve their function, thus attenuating endothelium damage, independent of the vasodilatory effects of NO. This review summarizes the metabolic alterations that underlie the molecular mechanisms that may be responsible for EPC decrease and dysfunction in DM-2 with emphasis on the involvement of the NO system.
authors.affiliation: Department of Cardiology, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Saher
authors.initials: S
authors.lastname: Hamed
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brenner
authors.forename: Ariel
authors.initials: A
authors.lastname: Roguin
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D009569:Nitric Oxide / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008077:Lipoproteins, LDL; D009569:Nitric Oxide; C517652:hemoglobin A1c protein, human; C099252:oxidized low density lipoprotein