title: Encapsulating peritoneal sclerosis associated with abnormal liver development in a young dog.
abstract: A 6-month-old male miniature pinscher dog developed chronic ascites, formation of fibrous membrane covering the abdominal organs, and numerous adhesions between the intestinal loops. The membrane and adhesions were surgically removed twice, but the dog died 1 month after initial presentation. Necropsy revealed recurrence of the membrane and intestinal adhesions. The fibrous membrane was composed of a thick layer of mature collagenous connective tissue, covered by immature collagenous connective tissue with mild lymphoplasmacytic infiltration, prominent neovascularization, and fibrin exudation. Similar fibrotic lesions were observed in the serosa of the liver, spleen, stomach and intestines. These findings are consistent with encapsulating peritoneal fibrosis reported in humans and dogs. The dog also had a maldeveloped liver, which is characterized by disorganized hepatic lobules and disarranged hepatic cords.
authors.affiliation: Laboratory of Veterinary Pathology, Osaka Prefecture University, Rinku-Orai Kita, Izumisano, Osaka, Japan. izawa@vet.osakafu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Izawa
authors.forename: Fumi
authors.initials: F
authors.lastname: Murai
authors.forename: Hideo
authors.initials: H
authors.lastname: Akiyoshi
authors.forename: Fumihito
authors.initials: F
authors.lastname: Ohashi
authors.forename: Jyoji
authors.initials: J
authors.lastname: Yamate
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kuwamura
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D017809:Fatal Outcome; D008099:Liver / Q000002:abnormalities*; D008107:Liver Diseases / Q000150:complications / Q000151:congenital / Q000628:therapy / Q000662:veterinary*; D008297:Male; D056627:Peritoneal Fibrosis / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone