title: Genetic modification of T cells.
abstract: Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.
authors.affiliation: Experimental Hematology Unit, Research Division of Regenerative Medicine, Gene Therapy and Stem Cells, Hematology and BMT Unit, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Bonini
authors.forename: Malcolm K
authors.initials: MK
authors.lastname: Brenner
authors.forename: Helen E
authors.initials: HE
authors.lastname: Heslop
authors.forename: Richard A
authors.initials: RA
authors.lastname: Morgan
mesh_terms: D019264:Adoptive Transfer / Q000379:methods* / Q000592:standards; D006801:Humans; D057131:Immune Evasion; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000637:transplantation*; D014162:Transfection; D019139:Tumor Escape