title: Complete resolution of a squamous cell carcinoma of the skin using intralesional 5-aminolevulinic acid photodynamic therapy intralesional PDT for SCC.
abstract: We present an 82-year-old female patient with a 2-year history of an infiltrative squamous cell carcinoma (SCC) on her right cheek. The patient was treated with one intralesional photodynamic therapy (PDT) session using 10% 5-aminolevulinic acid solution. We used red light by a non-coherent light source at a light dose of 100 J/cm² and a fluency rate of 100 mW/cm². Complete clinical and histological response was achieved 3 months after the treatment procedure. Cosmetic outcome was evaluated as fair. The patient remains disease free with the absence of any clinical sign of recurrence 16 months after PDT. Long-term follow-up is needed for assessment of recurrences. Optimization of the therapeutic protocol, as well as justification of our results in larger studies are needed in order to elicit safe conclusions.
authors.affiliation: First Dermatologic Department, Medical School, Aristotle University Thessaloniki, Thessaloniki, Greece. elenasotiriou@yahoo.gr
authors.forename: Eleni
authors.initials: E
authors.lastname: Sotiriou
authors.forename: Zoi
authors.initials: Z
authors.lastname: Apalla
authors.forename: Demetris
authors.initials: D
authors.lastname: Ioannides
mesh_terms: D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D010778:Photochemotherapy / Q000379:methods*; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000622:Aminolevulinic Acid