title: [false-positive results of human chorionic gonadotropin β measurement after high orchiectomy for stage i seminoma: report of a case].
abstract: A 21-year-old male presented at our hospital with a complaint of left scrotal swelling. The serum human chorionic gonadotropin-β (hCG-β) level was 1.3 ng/ml. A left high orchitectomy was performed, and a histological study demonstrated seminoma. Computerized tomography showed no evidence of metastasis. Adjuvant radiation therapy with 25 Gy was performed for stage I seminoma. Although complete clinical remission was achieved,the hCG-β level remained slightly positive (0.3-0.5 ng/ml). The urine hCG-β-core fragment was determined to be within normal limits. This confirmed that the result of serum hCG-β measurement was false-positive in our case. The patient received no additional treatment, and is free from recurrence 3 years and 1 month after surgery. In the testicular germ cell tumors,the measurement of urine hCG-β-core fragment is useful for differential diagnosis in cases of low level-positive serum hCG-β without clinical evidence of disease.
authors.affiliation: The Department of Urology, Kohka Public Hospital, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Tomita
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Nishikawa
authors.forename: Keitaand
authors.initials: K
authors.lastname: Takimoto
authors.forename: Chul Jang
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood* / Q000652:urine; D005189:False Positive Reactions; D006801:Humans; D008297:Male; D009919:Orchiectomy; D010446:Peptide Fragments / Q000652:urine; D018239:Seminoma / Q000175:diagnosis*; D013736:Testicular Neoplasms / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; C063554:urinary gonadotropin fragment