title: [Studies on anti-platelet activation effect and partial mechanisms of Taohong Siwu decoction].
abstract: OBJECTIVE
  To explore the anti-platelet activation effect and partial mechanisms of Taohong Siwu decoction (TSD).
  
  
  METHODS
  The effect to venous thrombosis model and pulmonary thromboembolism model induced by vein injecting ADP and Adr was observed. The platelet adhesion rate was analyzed by using spinning glass bottle, and the platelet aggregation rate induced by ADP, Adr was analyzed by using turbidimetry. The acute blood stasis rat model was established to analyze the content of plasm TXB2 and PGI2 by RIA, and the content of VWF, GMP-14 by ELISA.
  
  
  RESULTS
  TSD could effectively reduce platelet the adhesion rate of normal rat, inhibit the platelet aggregation of normal rat induced by ADP, Adr. It significantly reduced the plasma TXB2 VWF, and GMP-140 level of blood stasis rats. It also had significant tendency to increase 6-keto-PGF1alpha level.
  
  
  CONCLUSIONS
  TSD possessed obvious activity of inhibiting platelet activation. The mechanism related with the restraining of platelet adhesion, platelet aggregation and platelet releasion.
authors.affiliation: Key Laboratory of Chinese Medicine Research and Development in Anhui Province, Anhui College of Traditional Chinese Medicine, Hefei 230038, China. hanlan56@yahoo.com.cn
authors.forename: Lan
authors.initials: L
authors.lastname: Han
authors.forename: Daiyin
authors.initials: D
authors.lastname: Peng
authors.forename: Fan
authors.initials: F
authors.lastname: Xu
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D008516:Medicine, Chinese Traditional; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; C519463:Taohong Siwu decoction II