title: Neuropharmacological safety evaluation of jigrine: A polyherbal hepatoprotective formulation.
abstract: OBJECTIVE
  Jigrine is a herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants. Present study was designed to evaluate per se neuropharmacological effects of jigrine in mice.
  
  
  METHODS
  Jigrine was evaluated in a number of pharmacological test paradigms, viz. open field arena, actophotometer, hole board, rotarod, traction test, grip strength test, spontaneous alternation behavior, passive avoidance task, and phenobarbital sleeping time.
  
  
  CONCLUSIONS
  Jigrine pretreatment (1 and 2 ml/kg, p.o.) did not produce any significant effect as compared to normal saline treated animals and was found to be free from any acute undesirable central effects at these two dose levels.
authors.affiliation: Department of Pharmacology, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Najmi
authors.forename: K K
authors.initials: KK
authors.lastname: Pillai
authors.forename: S N
authors.initials: SN
authors.lastname: Pal
authors.forename: M
authors.initials: M
authors.lastname: Akhtar
authors.forename: M
authors.initials: M
authors.lastname: Mujeeb
authors.forename: A
authors.initials: A
authors.lastname: Aftab