title: A critical time window for the survival of neural progenitor cells by HDAC inhibitors in the hippocampus.
abstract: Histone deacetylase inhibitors (HDACIs) that modulate gene expression by inhibiting HDAC enzymes may contribute to the survival of immature hippocampal neurons. However, it remains unknown how and when HDACIs regulate the survival of newly generated immature hippocampal neurons. In the present study, if the treatment of valproic acid (VPA) and sodium butyrate (SBt) in the specific time window during the development of newly generated n eurons r esulted in the i ncreased survival of bromodeoxyuridine (BrdU)(+) neurons in the dentate gyrus (DG) of hippocampus in mice was investigated. It was found that the number of BrdU(+) cells, the expressions of anti-apoptotic Bcl-2 family members and pCREB [D1] were increased by HDACIs when HDACIs were treated no later than 2-3 weeks after BrdU labeling. This suggests that epigenetic modification within a specific time window is critical for the survival of newborn hippocampal neurons by inhibiting the apoptotic pathway.
authors.affiliation: Department of Biochemistry and Molecular Biology, Hanyang University, Seoul, Korea.
authors.forename: Byung-Woo
authors.initials: BW
authors.lastname: Kim
authors.forename: Sera
authors.initials: S
authors.lastname: Yang
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Hyeon
authors.initials: H
authors.lastname: Son
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects; D002087:Butyrates / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D058953:Neural Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014635:Valproic Acid / Q000494:pharmacology; D051020:bcl-X Protein / Q000378:metabolism
chemical_list: D002087:Butyrates; C492004:Creb1 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D056572:Histone Deacetylase Inhibitors; D051020:bcl-X Protein; D014635:Valproic Acid