title: The role of stem cells in cutaneous wound healing: what do we really know?
abstract: Wound repair is a complex process involving the orchestrated interaction of multiple growth factors, cytokines, chemokines, and cell types. Dysregulation of this process leads to problems such as excessive healing in the form of keloids and hypertrophic scars and chronic, nonhealing wounds. These issues have broad global implications. Stem cells offer enormous potential for enhancing tissue repair and regeneration following injury. The rapidly developing fields of stem cell biology and skin tissue engineering create translational opportunities for the development of novel stem cell-based wound-healing therapies.
authors.affiliation: Stanford, Calif.; Washington, D.C.; Pittsburgh, Pa.; Portland, Ore.; and Chapel Hill, N.C. From the Hagey Laboratory for Pediatric and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, and the Departments of Surgery of Georgetown University Hospital, University of Pittsburgh Medical Center, University of Oregon Medical Center, and University of North Carolina at Chapel Hill.
authors.forename: Sae Hee
authors.initials: SH
authors.lastname: Ko
authors.forename: Allison
authors.initials: A
authors.lastname: Nauta
authors.forename: Victor
authors.initials: V
authors.lastname: Wong
authors.forename: Jason
authors.initials: J
authors.lastname: Glotzbach
authors.forename: Geoffrey C
authors.initials: GC
authors.lastname: Gurtner
authors.forename: Michael T
authors.initials: MT
authors.lastname: Longaker
mesh_terms: D006801:Humans; D012867:Skin / Q000503:physiopathology; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy*