title: [SNP767A/T of FUS2 gene and lung cancer risk in Chinese population].
abstract: BACKGROUND
  FUS2 gene locating at 3p21.3 is considered a promising candidate tumor suppressor gene. The aim of this study is to examine the difference in FUS2-767A/T polymorphism site between lung cancer patients and normal controls in Chinese population.
  
  
  METHODS
  The genotype FUS2-767A/T was detected in 146 lung cancer patients and 113 normal controls by PCR-SSCP method. The relationship between lung cancer risk and difference in genotypes of FUS2 gene was analysed.
  
  
  RESULTS
  FUS2-767A/T was significantly related to histological type (P=0.044), age of the patients with lung cancer (P=0.011) and vessel cancer embolus (P=0.031) in lung cancer group. There was no significant difference in distribution of FUS2 genotypes between lung cancer patients and normal controls (P=0.945).
  
  
  CONCLUSIONS
  The results suggest that the FUS2-767A/T polymorphism may be a susceptibility factor for lung cancer among Chinese population.
authors.affiliation: Laboratory of Thoracic Surgical Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, P.R.China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Mu
authors.forename: Kang
authors.initials: K
authors.lastname: Shao
authors.forename: Cuiyan
authors.initials: C
authors.lastname: Zhang
authors.forename: Zhaoli
authors.initials: Z
authors.lastname: Chen
authors.forename: Junting
authors.initials: J
authors.lastname: Wan
authors.forename: Kezhi
authors.initials: K
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.forename: Meihua
authors.initials: M
authors.lastname: Xiong
authors.forename: Jie
authors.initials: J
authors.lastname: He