title: 4'-Methyl-3-(4-nitro-phen-yl)-4-phenyl-4,5,1',2',3',4'-hexa-hydro-spiro-[isoxazole-5,2'-naphthalen]-1'-one.
abstract: The title compound, C(25)H(20)N(2)O(4), is a new spiro-isoxazoline derivative. It contains a five-membered isoxazoline ring (A), a tetra-lone unit (E and D), a 4-nitro-phenyl substituent (B), and a phenyl ring (C). The isoxazoline ring (A) has an envelope conformation, while the cyclo-hexenone ring (D) has an inter-mediate sofa/half-chair conformation. The aromatic ring of the 4-nitro-phenyl substituent (B) is inclined at an angle of 78.97 (10)° to the phenyl ring (C). The rigid pharmacophore site, Osp(2)-C-C-Osp(3), is characterized by an O⋯O distance of 3.113 (2) Å and an O-C-C-O torsion angle of 97.8 (2)°. In the crystal structure, mol-ecules are linked by C-H⋯O contacts.
authors.forename: Ghali
authors.initials: G
authors.lastname: Alhouari
authors.forename: Abdelali
authors.initials: A
authors.lastname: Kerbal
authors.forename: Najib Ben
authors.initials: NB
authors.lastname: Larbi
authors.forename: Brahim
authors.initials: B
authors.lastname: Bennani
authors.forename: Taibi Ben
authors.initials: TB
authors.lastname: Hadda
authors.forename: Helen
authors.initials: H
authors.lastname: Stoeckli-Evans