title: Synthesis of orthogonally protected disulfide bridge mimetics.
abstract: Concise routes to four orthogonally protected, enantiopure disulfide bridge mimetics are reported. These four dicarba analogues possess an alkyne, an (E)-alkene, a (Z)-alkene, and an alkane as substitutes for the disulfide bridge. Selective deprotection of one of these mimetics is also illustrated.
authors.affiliation: Division of Pharmaceutical Chemistry, Faculty of Pharmacy, PO Box 56, FI-00014, University of Helsinki, Helsinki, Finland.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Tadd
authors.forename: Kristian
authors.initials: K
authors.lastname: Meinander
authors.forename: Kristina
authors.initials: K
authors.lastname: Luthman
authors.forename: Erik A A
authors.initials: EA
authors.lastname: Wallén
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D004220:Disulfides / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D004220:Disulfides