title: Efficacy of mefenamic acid and hyoscine for pain relief during saline infusion sonohysterography in infertile women: a double blind randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the efficacy and level of satisfaction from mefenamic acid and hyoscine when used for pain relief during saline infusion sonohysterography.
  
  
  METHODS
  In this double blind randomized controlled trial, 141 nulliparous women were allocated to receive 500 mg of mefenamic acid, 10mg of hyoscine or a placebo, which was packed in the same outer capsule. Saline infusion sonohysterography (SIS) was performed 30 min later by one operator. Pain and satisfaction scores were evaluated using a 10 cm visual analog scale. Baseline characteristics, pain and satisfaction scores were compared among the three groups. Pain scores were recorded before, after catheter insertion, during, immediately after, and 30 min after the procedure.
  
  
  RESULTS
  No statistically significant differences were found in baseline characteristics, pain and satisfaction scores among the three groups. Maximum pain during SIS was 4.40 ± 3.34, 4.67 ± 3.14 and 4.85 ± 3.19 in the mefenamic acid, hyoscine and placebo groups respectively. There was a 31.1% prevalence of intrauterine abnormality and the most frequent finding was endometrial polyp.
  
  
  CONCLUSIONS
  There is no benefit in using mefenamic acid and hyoscine in the prevention of pain occurring from SIS.
authors.affiliation: Infertility Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
authors.forename: Rossathum
authors.initials: R
authors.lastname: Jareethum
authors.forename: Singpetch
authors.initials: S
authors.lastname: Suksompong
authors.forename: Somsin
authors.initials: S
authors.lastname: Petyim
authors.forename: Japarath
authors.initials: J
authors.lastname: Prechapanich
authors.forename: Pitak
authors.initials: P
authors.lastname: Laokirkkiat
authors.forename: Roungsin
authors.initials: R
authors.lastname: Choavaratana
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004717:Endometrium / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects*; D007247:Infertility, Female / Q000209:etiology*; D008528:Mefenamic Acid / Q000627:therapeutic use*; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D017060:Patient Satisfaction; D011127:Polyps / Q000000981:diagnostic imaging / Q000503:physiopathology; D012601:Scopolamine / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects*; D014463:Ultrasonography; D014591:Uterine Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D008528:Mefenamic Acid; D012965:Sodium Chloride; D012601:Scopolamine