title: Miconazole mucoadhesive tablet for oropharyngeal candidiasis.
abstract: Oropharyngeal candidiasis is a commonly encountered problem in daily clinical practice. Topical therapies for oropharyngeal candidiasis are considered preferable to systemic therapies in most patient populations. However, traditional topical therapies have limitations including short contact time with the oral mucosa and the need for multiple doses each day. Miconazole mucoadhesive tablet has recently been approved in Europe (Loramyc®) and the USA (Oravig™) for the treatment of oropharyngeal candidiasis. This tablet adheres to the oral mucosa and provides sustained local release of miconazole over a period of several hours with just one daily application. This article reviews the pharmacology, safety and efficacy of this novel agent.
authors.affiliation: Section of Oral Medicine, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1605, USA. lalla@uchc.edu
authors.forename: Rajesh V
authors.initials: RV
authors.lastname: Lalla
authors.forename: René-Jean
authors.initials: RJ
authors.lastname: Bensadoun
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000382:microbiology; D005060:Europe; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D009061:Mouth Mucosa / Q000382:microbiology; D009960:Oropharynx / Q000382:microbiology; D016032:Randomized Controlled Trials as Topic; D013607:Tablets / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D014481:United States
chemical_list: D000935:Antifungal Agents; D013607:Tablets; D008825:Miconazole