title: Immunogenicity and tolerability of an inactivated and adjuvanted pandemic H1N1 influenza vaccine, in HIV-1-infected patients.
abstract: We evaluated the efficacy and tolerability of a single dose of the split virion AS03-adjuvanted pandemic H1N1 influenza vaccine (A/California/7/2009) in 84 HIV-1 infected individuals. Antibody titers were determined by hemagglutination inhibition assay and by microneutralization. Vaccine was well tolerated. At 21 days post vaccination, 56 (67%) patients had seroconverted. There was no correlation between baseline CD4 cell count (p=0.539) or HIV viral load (p=0.381) and immune response. Other vaccine strategies should be evaluated in this HIV population, to improve response rates.
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Qc, Canada. c.tremblay@umontreal.ca
authors.forename: Cécile L
authors.initials: CL
authors.lastname: Tremblay
authors.forename: Danielle
authors.initials: D
authors.lastname: Rouleau
authors.forename: Claude
authors.initials: C
authors.lastname: Fortin
authors.forename: Emil
authors.initials: E
authors.lastname: Toma
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sylla
authors.forename: Lise
authors.initials: L
authors.lastname: Cyr
authors.forename: Serge
authors.initials: S
authors.lastname: Cote
authors.forename: Mariana
authors.initials: M
authors.lastname: Baz
authors.forename: John
authors.initials: J
authors.lastname: Sampalis
authors.forename: Lydie
authors.initials: L
authors.lastname: Trautman
authors.forename: Rafick-Pierre
authors.initials: RP
authors.lastname: Sékaly
authors.forename: Guy
authors.initials: G
authors.lastname: Boivin
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D011446:Prospective Studies; D011792:Quebec; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D019562:Viral Load
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated