title: Synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives: application in solution peptide synthesis.
abstract: A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide synthesis. The new triazinyloxyimino derivatives failed to activate the carboxyl group during formation of peptide bonds, but gave the corresponding N-triazinyl amino acid derivatives as a major product. The oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) uronium salt was superior to other uronium salts in terms of racemization, while 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT, 9) gave the best results.
authors.affiliation: Women Students-Medical Studies and Sciences Sections, Chemistry Department, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia. tarfah-w@hotmail.com
authors.forename: Tarfah I
authors.initials: TI
authors.lastname: Al-Warhi
authors.forename: Hassan M A
authors.initials: HM
authors.lastname: Al-Hazimi
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Faham
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry
chemical_list: D010455:Peptides; D014230:Triazoles