title: Is insulin resistance a disorder of the brain?
abstract: There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.
authors.affiliation: Jawaharlal Nehru Technological University, Kakinada 533 003, India. undurti@hotmail.com
authors.forename: Undurti N
authors.initials: UN
authors.lastname: Das
authors.forename: Gaston
authors.initials: G
authors.lastname: Repossi
authors.forename: Alejandro
authors.initials: A
authors.lastname: Dain
authors.forename: Aldo Renato
authors.initials: AR
authors.lastname: Eynard
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001927:Brain Diseases / Q000503:physiopathology*; D007031:Hypothalamus / Q000502:physiology*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D009479:Neuropeptides / Q000502:physiology; D009765:Obesity / Q000503:physiopathology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: D015306:Biogenic Monoamines; D007328:Insulin; D009479:Neuropeptides