title: Family coronary heart disease: a call to action.
abstract: A family history of coronary heart disease (CHD) is an accepted risk factor for cardiovascular events and is independent of common CHD risk factors. Advances in the understanding of genetic influences on CHD risk provide the opportunity to apply this knowledge and improve patient care. Utility of inherited cardiovascular risk testing exists by utilizing both phenotypes and genotypes and includes improved CHD risk prediction, selection of the most appropriate treatment, prediction of outcome, and family counseling. The major impediment to widespread clinical adoption of this concept involves un-reimbursed staff time, educational needs, access to a standardized and efficient assessment mechanism, and privacy issues. The link between CHD and inheritance is indisputable and the evidence strong and consistent. For clinicians, the question is how to utilize this information, in an efficient manner, in order to improve patient care and detection of high-risk family members.
authors.affiliation: Center for Genomics and Human Health, Saint Joseph's Translational Research Institute, Atlanta, Georgia, USA. Robert.superko@celera.com
authors.forename: H Robert
authors.initials: HR
authors.lastname: Superko
authors.forename: Robert
authors.initials: R
authors.lastname: Roberts
authors.forename: Brenda
authors.initials: B
authors.lastname: Garrett
authors.forename: Lakshmana
authors.initials: L
authors.lastname: Pendyala
authors.forename: Spencer
authors.initials: S
authors.lastname: King
mesh_terms: D003327:Coronary Disease / Q000175:diagnosis / Q000191:economics / Q000235:genetics* / Q000628:therapy; D003362:Cost-Benefit Analysis; D005817:Genetic Counseling / Q000191:economics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000191:economics; D017048:Health Care Costs; D040941:Heredity; D006801:Humans; D010375:Pedigree; D010641:Phenotype; D018570:Risk Assessment; D012307:Risk Factors