title: Tirucallane triterpenoids from Cornus walteri.
abstract: Twelve new tirucallane triterpenoids, named cornusalterins A-L (1-12), and two known tirucallane triterpenoids, deoxyflindissone (13) and (-)-leucophyllone (14), were isolated from a MeOH extract of stems and stem bark of Cornus walteri. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D NMR analyses. Compounds 12 and 13, possessing a tetrahydrofuran ring in the side chain, exhibited significant cytotoxic activity against the A549, SK-OV-3, SK-MEL-2, and XF498 cell lines.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029768:Cornus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C514393:tirucallane