title: Dual-mode imaging of cutaneous tissue oxygenation and vascular function.
abstract: Accurate assessment of cutaneous tissue oxygenation and vascular function is important for appropriate detection, staging, and treatment of many health disorders such as chronic wounds. We report the development of a dual-mode imaging system for non-invasive and non-contact imaging of cutaneous tissue oxygenation and vascular function. The imaging system integrated an infrared camera, a CCD camera, a liquid crystal tunable filter and a high intensity fiber light source. A Labview interface was programmed for equipment control, synchronization, image acquisition, processing, and visualization. Multispectral images captured by the CCD camera were used to reconstruct the tissue oxygenation map. Dynamic thermographic images captured by the infrared camera were used to reconstruct the vascular function map. Cutaneous tissue oxygenation and vascular function images were co-registered through fiduciary markers. The performance characteristics of the dual-mode image system were tested in humans.
authors.affiliation: Department of Biomedical Engineering, The Ohio State University, USA.
authors.forename: Ronald X
authors.initials: RX
authors.lastname: Xu
authors.forename: Kun
authors.initials: K
authors.lastname: Huang
authors.forename: Ruogu
authors.initials: R
authors.lastname: Qin
authors.forename: Jiwei
authors.initials: J
authors.lastname: Huang
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Xu
authors.forename: Liya
authors.initials: L
authors.lastname: Ding
authors.forename: Urmila S
authors.initials: US
authors.lastname: Gnyawali
authors.forename: Gayle M
authors.initials: GM
authors.lastname: Gordillo
authors.forename: Surya C
authors.initials: SC
authors.lastname: Gnyawali
authors.forename: Chandan K
authors.initials: CK
authors.lastname: Sen
mesh_terms: D001808:Blood Vessels / Q000502:physiology; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D007259:Infrared Rays; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D012867:Skin / Q000098:blood supply* / Q000378:metabolism*; D013817:Thermography / Q000379:methods
chemical_list: D010100:Oxygen