title: Associations between adipokines and obesity-related cancer.
abstract: There is increasing evidence that obesity may have pathophysiological effects that extend beyond its well-known co-morbidities; in particular its role in cancer has received considerable epidemiological support. As adipose tissue becomes strongly established as an endocrine organ, two of its most abundant and most investigated adipokines, leptin and adiponectin, are also taken beyond their traditional roles in energy homeostasis, and are implicated as mediators of the effects of obesity on cancer development. This review examines these adipokines in relation to the prostate, breast, colorectal, thyroid, renal, pancreatic, endometrial and oesophageal cancers, and how they may orchestrate the influence of obesity on the development of these malignancies.
authors.affiliation: Department of Translational Medicine, The John Curtin School of Medical Research, The Australian National University, Garran Rd, building 131, Canberra, Australia.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Paz-Filho
authors.forename: Ee Lyn
authors.initials: EL
authors.lastname: Lim
authors.forename: Ma-Li
authors.initials: ML
authors.lastname: Wong
authors.forename: Julio
authors.initials: J
authors.lastname: Licinio
mesh_terms: D052242:Adiponectin / Q000502:physiology*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000209:etiology / Q000503:physiopathology; D015179:Colorectal Neoplasms / Q000209:etiology / Q000503:physiopathology; D016889:Endometrial Neoplasms / Q000209:etiology / Q000503:physiopathology; D004938:Esophageal Neoplasms / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology / Q000503:physiopathology; D020738:Leptin / Q000502:physiology*; D008297:Male; D009369:Neoplasms / Q000209:etiology*; D009765:Obesity / Q000150:complications*; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000209:etiology / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000209:etiology / Q000503:physiopathology
chemical_list: D052242:Adiponectin; D020738:Leptin