title: Sonographic abnormalities in idiopathic restless legs syndrome (RLS) and RLS in Parkinson's disease.
abstract: We aimed to investigate and compare sonographic abnormalities in the substantia nigra (SN) in patients with idiopathic restless legs syndrome (iRLS), those with RLS and Parkinson's disease (RLS-PD), those with idiopathic Parkinson's disease (iPD), and healthy controls. Study participants totaled 60 patients with RLS (41 iRLS, 19 RLS-PD), 25 iPD patients, and 35 age-matched healthy controls. Comparing all groups, the SN region's echogenicity area in the iRLS patients was significantly decreased compared with that in the PD-RLS, iPD, and control groups (p < 0.0001), and the PD-RLS group demonstrated a significantly increased echogenicity area compared with the control group (p < 0.05) and iRLS group (p < 0.0001). We found that the RLS-PD group's sonological results and clinical findings were different from those of the iRLS group.
authors.affiliation: Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, 761-1, Sanggye 7 dong, No won gu, Seoul 139-707, Republic of Korea.
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Ryu
authors.forename: Myung Sik
authors.initials: MS
authors.lastname: Lee
authors.forename: Jong Sam
authors.initials: JS
authors.lastname: Baik
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging*; D012148:Restless Legs Syndrome / Q000150:complications / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013378:Substantia Nigra / Q000000981:diagnostic imaging*; D014463:Ultrasonography