title: [Correlation between multi-slice spiral CT pulmonary perfusion imaging and cavity of microvessel in lung cancer].
abstract: OBJECTIVE
  To investigate the relation between multi-slice spiral CT pulmonary perfusion imaging and the cavity of microvessel in lung cancer.
  
  
  METHODS
  Altogether 36 patients with malignant nodules who underwent multi-slice spiral CT perfusion scan were examined.The perfusion parameters were collected and compared with the microvessel density (MVD), the incomplete lumen MVD, and the differentiation of non-small cell lung cancer (NSCLC). The patients were divided into a hyper-perfusion group and a hypo-perfusion group by the value of perfusion parameters. The maturity of microvessel and the degree of differentiation in NSCLC between the 2 groups was analyzed.
  
  
  RESULTS
  Blood flow (BF), blood volume (BV), and peak enhancement image(PEI) of the malignant nodules were (39.7±11.5) mL/(100 mg.min), (8.6±3.8)mL/100 g, and (20.1±8.6)HU, respectively. There was a positive correlation between PEI and MVD(r=0.645,P<0.01), and a negative correlation between BF and MVD(r=-0.280,P=0.048). There were negative correlations of BF, BV, PEI with the incomplete lumen MVD (P<0.05). BF had the highest correlation coefficient(r=-0.882,P<0.01).The incomplete lumen MVD of the hyper-perfusion group was significantly lower than that of hypo-perfusion group (P<0.05),but there was no significant difference in MVD between the 2 groups. There were negative correlations of BF, BV,PEI with the degree of differentiation (P<0.05). BF had the highest correlation coefficient(r=-0.751,P<0.01).
  
  
  CONCLUSIONS
  Multi-slice spiral CT pulmonary perfusion imaging is helpful to evaluate the degree of differentiation and status of angiogenesis in lung cancer, and its basis is the cavity of microvessel.
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Jinkang
authors.initials: J
authors.lastname: Liu
authors.forename: Zeng
authors.initials: Z
authors.lastname: Xiong
authors.forename: Chengping
authors.initials: C
authors.lastname: Hu
authors.forename: Moling
authors.initials: M
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia
mesh_terms: D002196:Capillaries / Q000473:pathology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D003074:Solitary Pulmonary Nodule / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D036542:Tomography, Spiral Computed / Q000379:methods*