title: DNA replication licensing control and rereplication prevention.
abstract: Eukaryotic DNA replication is tightly restricted to only once per cell cycle in order to maintain genome stability. Cells use multiple mechanisms to control the assembly of the prereplication complex (pre-RC), a process known as replication licensing. This review focuses on the regulation of replication licensing by posttranslational modifications of the licensing factors, including phosphorylation, ubiquitylation and acetylation. These modifications are critical in establishing the pre-RC complexes as well as preventing rereplication in each cell cycle. The relationship between rereplication and diseases, including cancer and virus infection, is discussed as well.
authors.affiliation: Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX 77030, USA.
authors.forename: Chonghua
authors.initials: C
authors.lastname: Li
authors.forename: Jianping
authors.initials: J
authors.lastname: Jin
mesh_terms: D000107:Acetylation; D000818:Animals; D002453:Cell Cycle; D004261:DNA Replication / Q000235:genetics* / Q000502:physiology*; D042522:DNA Replication Timing; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D042822:Genomic Instability; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination; D014777:Virus Diseases / Q000235:genetics / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm