title: Clinically relevant changes in emotional expression in children with ADHD treated with lisdexamfetamine dimesylate.
abstract: OBJECTIVE
  To describe clinically relevant effects of lisdexamfetamine dimesylate (LDX) on emotional expression (EE) in children with ADHD.
  
  
  METHODS
  Children with ADHD participated in a 7-week, open-label, LDX dose-optimization study. Expression and Emotion Scale for Children (EESC) change scores were analyzed post hoc using two methods to determine proportion of participants with different categories of clinical response based on (a) clinically significant (movement >2 SD from baseline mean)/reliable change (not due to measurement error) and (b) standard error of measurement (SEM) as a measure of clinically meaningful change.
  
  
  RESULTS
  With LDX, no participants showed clinically significant/reliable improvement; 0.7% showed clinically significant/reliable deterioration of EE by reliable change index and movement from baseline mean. One third of participants had improved EE by SEM criteria; 9.2% had categorical worsening.
  
  
  CONCLUSIONS
  Using clinically meaningful change and clinically significant/reliable change categories derived from the EESC, most participants had no worsening of EE with LDX.
authors.affiliation: Claghorn-Lesem Research Clinic, Bellaire, TX 77008, USA. alain@claghorn-lesem.com
authors.forename: Alain
authors.initials: A
authors.lastname: Katic
authors.forename: Lawrence
authors.initials: L
authors.lastname: Ginsberg
authors.forename: Rakesh
authors.initials: R
authors.lastname: Jain
authors.forename: Ben
authors.initials: B
authors.lastname: Adeyi
authors.forename: Bryan
authors.initials: B
authors.lastname: Dirks
authors.forename: Thomas
authors.initials: T
authors.lastname: Babcock
authors.forename: Brian
authors.initials: B
authors.lastname: Scheckner
authors.forename: Cynthia
authors.initials: C
authors.lastname: Richards
authors.forename: Robert
authors.initials: R
authors.lastname: Lasser
authors.forename: Atilla
authors.initials: A
authors.lastname: Turgay
authors.forename: Robert L
authors.initials: RL
authors.lastname: Findling
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects*; D005260:Female; D006801:Humans; D000069478:Lisdexamfetamine Dimesylate; D008297:Male; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D000069478:Lisdexamfetamine Dimesylate; D003913:Dextroamphetamine