title: The significance of anticardiolipin antibody and immunologic abnormality in livedoid vasculitis.
abstract: OBJECTIVE
  To evaluate the significance of anticardiolipin and immunologic abnormality in the livedoid vasculitis (LV).
  
  
  METHODS
  30 patients with biopsy-proven LV and 30 normal controls involved in the study. Indirect immunofluorescence, immunoblot, and ELISA were used for detecting antinuclear antibody (ANA), circulating immune complex, immune globulin, anticardiophospholipin antibody (ACA), and anti-β(2) GP1.
  
  
  RESULTS
  ANA was positive in four patients with LV, and among them, two patients were diagnosed as Systemic Lupus Erythematosus (SLE) later. Addition to the two SLE patients, the level of ENA and immunoglobulin were normal in the rest of patients. Anticardiolipin antibodies were present in 13 (43.33%), and β(2) GP1 was present in nine (30%) of 30 patients. There were significant differences between LV and controls.
  
  
  CONCLUSIONS
  ACA is one of important pathogenesis of LV. Numerous heterogeneous coagulation abnormalities and thrombogenesis may involve the LV.
authors.affiliation: Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, China. fengsuying@medmail.com.cn
authors.forename: Su-ying
authors.initials: SY
authors.lastname: Feng
authors.forename: Pei-ying
authors.initials: PY
authors.lastname: Jin
authors.forename: Chang-geng
authors.initials: CG
authors.lastname: Shao
mesh_terms: D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000097:blood; D001706:Biopsy; D002308:Cardiolipins / Q000097:blood / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D054068:Livedo Reticularis / Q000097:blood / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology; D008297:Male; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D002308:Cardiolipins; D053482:beta 2-Glycoprotein I