title: Possible cross-species transmission of circoviruses and cycloviruses among farm animals.
abstract: Circoviruses consist of highly prevalent and genetically diverse porcine and avian pathogens. The genomes of cycloviruses, a proposed new genus in the family Circoviridae, were recently identified in human and chimpanzee faeces. Here, six cyclovirus and four circovirus genomes from the tissues of chickens, goats, cows, and a bat were amplified and sequenced using rolling-circle amplification and inverse PCR. A goat cyclovirus was nearly identical to a cyclovirus from a cow. USA beef contained circoviruses with >99% similarity to porcine circovirus 2b. Circoviruses in chicken were related to those of pigeons. The close genetic similarity of a subset of cycloviruses and circoviruses replicating in distinct animal species may reflect recent cross-species transmissions. Further studies will be required to determine the impact of these highly prevalent infections on the health of farm animals.
authors.affiliation: Blood Systems Research Institute, San Francisco, CA 94118, USA.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.forename: Tongling
authors.initials: T
authors.lastname: Shan
authors.forename: Oderinde Bamidele
authors.initials: OB
authors.lastname: Soji
authors.forename: Muhammad Masroor
authors.initials: MM
authors.lastname: Alam
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Kunz
authors.forename: Sohail Zahoor
authors.initials: SZ
authors.lastname: Zaidi
authors.forename: Eric
authors.initials: E
authors.lastname: Delwart
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000635:transmission / Q000821:virology*; D002645:Chickens; D002685:Chiroptera; D018136:Circoviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D018173:Circoviridae Infections / Q000635:transmission / Q000662:veterinary*; D016000:Cluster Analysis; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D015511:Goat Diseases / Q000635:transmission / Q000821:virology*; D006041:Goats; D008969:Molecular Sequence Data; D010802:Phylogeny; D011201:Poultry Diseases / Q000635:transmission / Q000821:virology*; D017422:Sequence Analysis, DNA; D014481:United States
chemical_list: D004279:DNA, Viral