title: Soluble levels of cell adhesion molecules (CAMs) in coronary artery disease.
abstract: OBJECTIVE
  To analyze soluble levels ofcell adhesion molecules (CAM) such as Intercellular CAM (ICAM), vascular CAM (VCAM-1), platelet endothelial CAM (PECAM-1), Endothelial (E)-selectin, and Platelet (P)-selectin in coronary artery disease patients and correlate with degree of severity of the disease.
  
  
  METHODS
  Study population included patients who suffered myocardial infarction at presentation (N=49) and those with unstable angina (N=79) and stable angina (N=14). Soluble levels of CAMs were measured by ELISA.
  
  
  RESULTS
  At acute event in AMI patients, there was significant rise of soluble (s) E-selectin (4.5 fold, P = 0.001), sVCAM-1 (65.6%, p = 0.001), sPECAM-1 (46.2%, p = 0.02), sP-selectin (42.7%, p = 0.001) and sICAM-1 (20.1%, p = 0.003) as compared to controls. In unstable angina group as compared to AMI there was significant decrease in the levels observed in, sE-selectin (62.7%, p = 0.001), sPECAM-1 (47.5%, p = 0.001) as well as sVCAM-1 (17.9%, p = 0.04) and insignificant decrease with respect to sICAM-1 and no change with respect to sP-selectin levels. Stable angina group as compared to unstable angina group demonstrated no significant difference in sCAMs and the trend with AMI group was similar to that seen between unstable angina and AMI group. Significantly elevated levels of sE-selectin, sVCAM-1 and sPECAM-1 at acute event suggest them to be causal molecules as well as markers of plaque destabilization. Levels of sP-selectin in stable angina were similar to that observed in AMI and unstable angina groups suggesting elevated platelet activation in stable angina as well.
authors.affiliation: Sir H. N. Hospital and Research Centre, Mumbai, Maharashtra, India.
authors.forename: Manoj R
authors.initials: MR
authors.lastname: Mashru
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Shah
authors.forename: Surendra L
authors.initials: SL
authors.lastname: Soneji
authors.forename: Yunus S
authors.initials: YS
authors.lastname: Loya
authors.forename: Jagdish B
authors.initials: JB
authors.lastname: Vasvani
authors.forename: Sachin
authors.initials: S
authors.lastname: Payannavar
authors.forename: Amar
authors.initials: A
authors.lastname: Walvalkar
authors.forename: Shilpa S
authors.initials: SS
authors.lastname: Mithbawkar
authors.forename: Rajashree
authors.initials: R
authors.lastname: Mokal
authors.forename: Ketki
authors.initials: K
authors.lastname: Kudalkar
authors.forename: Ajin
authors.initials: A
authors.lastname: Abraham
authors.forename: Priti K
authors.initials: PK
authors.lastname: Thakur
authors.forename: Kavita K
authors.initials: KK
authors.lastname: Shalia
mesh_terms: D000328:Adult; D000367:Age Factors; D000789:Angina, Unstable / Q000097:blood*; D015815:Cell Adhesion Molecules; D003327:Coronary Disease / Q000097:blood*; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D012307:Risk Factors; D019087:Selectins / Q000097:blood; D012737:Sex Factors
chemical_list: D015815:Cell Adhesion Molecules; D019087:Selectins