title: B cell immunotherapy in autoimmunity--2010 update.
abstract: B cells play important roles in normal immunity and human disease. While much has been learned from elegant studies utilizing genetically modified mice or with immunotherapy in normal and in autoimmune mice, we are merely at the start of learning about the mechanism(s) by which B cells contribute to human autoimmune disease. Here, I will review the most recent insights obtained with immunomodulatory therapies in human disease highlighting the clinical and immunological lessons we have learned with B cell depleting (e.g., rituximab) and immunomodulatory (e.g., BAFF/BLys neutralization through belimumab) therapies.
authors.affiliation: Department of Immunology, Genentech, Inc., One DNA Way, MS-34, Building 11-215, South San Francisco, CA 94080, USA. acc@gene.com
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Chan
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000628:therapy*; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D056747:Immunomodulation; D007167:Immunotherapy; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D000069283:Rituximab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab; C511911:belimumab