title: How pharmacogenomics of biological response modifiers will influence clinical response and toxicity in dermatology.
abstract: Biological response modifiers (BRMs) have dramatically changed therapeutic approaches in dermatology. Pharmacogenomic studies are increasingly integral to the early development phases of targeted therapies. The first evidence supporting the impact that genetic background has on responses to BRMs was from rituximab, where the clinical response was correlated with Fc-gamma receptor gene polymorphisms. Later, many studies were done to investigate the impact of gene polymorphism on the mechanism of action of BRMs. Growing evidence supports the view that both efficacy and toxicity of BRMs can be highly influenced by genetic background. The foreseeable objective is to select personalized therapeutics, based on genetics characteristics that will result in more efficient and less toxic treatment. We review the current data focusing on the BRMs widely used in the practice of dermatology.
authors.affiliation: Service de dermatologie, Université Claude Bernard Lyon I, Hospices Civils de Lyon, Lyon, France. stephane.dalle@chu-lyon.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dalle
authors.forename: Luc
authors.initials: L
authors.lastname: Thomas
authors.forename: Neil H
authors.initials: NH
authors.lastname: Shear
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001549:Benzamides; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004351:Drug Resistance / Q000235:genetics*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics*; D006801:Humans; D000068877:Imatinib Mesylate; D007155:Immunologic Factors / Q000627:therapeutic use*; D010597:Pharmacogenetics; D010879:Piperazines / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D057285:Precision Medicine; D011743:Pyrimidines / Q000627:therapeutic use; D017452:Receptors, IgG / Q000037:antagonists & inhibitors / Q000235:genetics; D000069283:Rituximab; D012871:Skin Diseases / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000235:genetics*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D001549:Benzamides; D003879:Dermatologic Agents; D007155:Immunologic Factors; D010879:Piperazines; D011743:Pyrimidines; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha; D000069283:Rituximab; D000068877:Imatinib Mesylate; D066246:ErbB Receptors