title: A stimulating way to improve T cell responses to poxvirus-vectored vaccines.
abstract: Vaccines remain one of the most cost-effective public health measures. Despite ongoing efforts, protective vaccines against cancer and many infectious diseases, including malaria, tuberculosis, and HIV/AIDS, are still not in hand. Most investigators believe that to succeed against these difficult targets, vaccines that generate potent T cell responses are needed. In this issue of the JCI, Salek-Ardakani et al. show how the relative virulence of a virus/vaccine vector affects the memory CD8+ T cells generated and how the response may be enhanced. The work has important implications for the development of future vaccines that aim to trigger CD8+ T cell responses.
authors.affiliation: University of Pennsylvania School of Medicine, Department of Medicine, Division of Infectious Diseases, Philadelphia, Pennsylvania 19104-6073, USA. isaacs@mail.med.upenn.edu
authors.forename: Stuart N
authors.initials: SN
authors.lastname: Isaacs
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005822:Genetic Vectors; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D018448:Models, Immunological; D011212:Poxviridae / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics* / Q000276:immunology*; D014774:Virulence / Q000235:genetics / Q000276:immunology
chemical_list: D014614:Vaccines, Synthetic