title: Evaluation of biocompatibility of Targis Dentin and Artglass by using subcutaneous implantation test.
abstract: BACKGROUND
  Biocompatibility of a crown-bridge material is as important as its physical and mechanical properties. It is also one of the most important factors for the long-lasting clinical success of that restoration. It directly contacts the vital prepared tooth and that is the reason it has to be nontoxic to the local tissues, such as the pulp, gingiva, or the rest of the body. Materials with different physical properties are used in the conventional fixed prosthodontic restorations. Recently, metal-free systems that are reinforced with fibers have been improved for crown and bridge restorations. These new composite systems have the advantages of both ceramic and polymer chemistry.
  
  
  METHODS
  In this research, biocompatibility of two ceramic-polymer-based prosthetic materials (Targis Dentin® and Artglass Dentin® ) was studied using a subcutaneous implantation test on rats. Initially (15 th day) mild inflammatory reactions were observed in tissues, which directly contacted the Artglass, Targis, and control tubes. These probably originated from the surgical traumas. After the 90th day of implantation, these reactions resolved and healthy, well-organized fibrous connective capsules were seen around the implants.
  
  
  RESULTS
  Initially (15 th day) mild inflammatory reactions were observed in tissues, which directly contacted the Artglass, Targis, and control tubes. These probably originated from the surgical traumas. After the 90 th day of implantation, these reactions resolved and healthy, well-organized fibrous connective capsules were seen around the implants.
  
  
  CONCLUSIONS
  At the end of the study, according to the FDI and ISO-7405 standards, Targis and Artglass indicated biocompatibility with the subcutaneous connective tissue of the rat.
authors.affiliation: Department of Prosthodontics, Hacettepe University, Ankara, Turkey. nalansulesonmez@gmail.com
authors.forename: Nalan Sule
authors.initials: NS
authors.lastname: Sonmez
authors.forename: Erhan
authors.initials: E
authors.lastname: Sonmez
authors.forename: Cihan
authors.initials: C
authors.lastname: Akcaboy
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002196:Capillaries / Q000473:pathology; D002481:Cellulitis / Q000473:pathology; D002516:Ceramics / Q000737:chemistry*; D003188:Composite Resins / Q000737:chemistry*; D003238:Connective Tissue / Q000473:pathology; D003764:Dental Materials / Q000737:chemistry*; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D005899:Glass Ionomer Cements / Q000737:chemistry*; D020007:Implants, Experimental; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008422:Materials Testing; D009504:Neutrophils / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D011138:Polytetrafluoroethylene; D051381:Rats; D017208:Rats, Wistar; D012823:Silicate Cement / Q000737:chemistry*; D040521:Subcutaneous Tissue / Q000473:pathology; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D003188:Composite Resins; D003764:Dental Materials; D005899:Glass Ionomer Cements; C111841:ceromer; C111282:dental polyglass; D012823:Silicate Cement; D011138:Polytetrafluoroethylene