title: Colon carcinoma--classification into right and left sided cancer or according to colonic subsite?--Analysis of 29,568 patients.
abstract: BACKGROUND
  It is common to distinguish between right and left colon cancer (RCC and LCC). But, little is known about the influence of its exact location on the tumor stage and characteristics when considering the colonic subsite within the right or left colon.
  
  
  METHODS
  During a five-year period, 29,568 consecutive patients were evaluated by data from the German multi-centered observational study "Colon/Rectal Carcinoma". Patients were split into 7 groups, each group representing a colonic subsite. They were compared regarding demographic factors, tumor stage, metastatic spread and histopathological characteristics.
  
  
  RESULTS
  Analysis of tumor differentiation and histological subtype revealed a linear correlation to the ileocecal valve, supporting the right and left side classification model. However, cancers arising from the RCC's cecum (52.3%) and LCC's splenic flexure (51.0%) showed the highest proportion of UICC stage III/IV tumors and lymphatic invasion, whereas the RCC's ascending colon (46.5%) and LCC's descending (44.7%) showed the lowest, which supports a more complex classification system, breaking down the right and left sides into colonic subsites.
  
  
  CONCLUSIONS
  Age, tumor grade and histological subtype support the right and left side classification model. However, gender, UICC stage, metastatic spread, T and N status, and lymphatic invasion correlated with a specific colonic subsite, irrespective of the side. The classification of RCC or LCC provides a general understanding of the tumor, but identification of the colonic subsite provides additional prognostic information. This study shows that the standard right and left side classification model may be insufficient.
authors.affiliation: Department of General, Visceral and Vascular Surgery, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, Magdeburg D-39120, Germany. frankbenedix@gmx.de
authors.forename: F
authors.initials: F
authors.lastname: Benedix
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: P
authors.initials: P
authors.lastname: Mroczkowski
authors.forename: I
authors.initials: I
authors.lastname: Gastinger
authors.forename: H
authors.initials: H
authors.lastname: Lippert
authors.forename: R
authors.initials: R
authors.lastname: Kube
mesh_terms: D000328:Adult; D015179:Colorectal Neoplasms / Q000145:classification* / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging