title: [Pendrin: its role in kidney function and hypertension].
abstract: Loss-of-function mutations of the pendrin gene are responsible for a pathology characterized by dysfunctions of thyroid and inner ear. However, it rapidly appeared after its discovery that the anion exchanger encoded by this gene plays a central role in kidneys. This brief review pictures the evolution of our knowledge regarding renal functions of pendrin, with a special emphasis to its recently identified roles in the maintenance of sodium homeostasis and blood pressure.
authors.affiliation: Universités Paris 5 et Paris 6, Inserm (UMRS 872) et CNRS (ERL 7226), Laboratoire de génomique, physiologie et physiopathologie rénales, Centre de recherche des Cordeliers, 15, rue de l'École de Médecine, 75006 Paris, France. alain.doucet@crc.jussieu.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Doucet
authors.forename: Dominique
authors.initials: D
authors.lastname: Eladari
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000818:Animals; D027321:Anion Transport Proteins / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D001834:Body Water / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D006042:Goiter / Q000235:genetics / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000235:genetics / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D017136:Ion Transport; D007668:Kidney / Q000502:physiology*; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009154:Mutation; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D000076988:Sulfate Transporters
chemical_list: D027321:Anion Transport Proteins; D002712:Chlorides; D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; C494849:Slc26a4 protein, mouse; D000076988:Sulfate Transporters; D012964:Sodium; D011188:Potassium