title: Primitive neuroectodermal tumor after radiation therapy for craniopharyngioma.
abstract: The authors report a case of primitive neuroectodermal tumor induced by radiation therapy of craniopharyngioma. This African-American male patient originally presented with craniopharyngioma, for which he underwent resection and whole-brain radiation therapy. Eight years later, at the age of 20 years, he returned with a left facial droop and left hemiparesis. A right basal ganglia mass was identified and resected. Histopathological examination identified the lesion as primitive neuroectodermal tumor. Although radiation therapy has shown to be beneficial in decreasing the recurrence rate in subtotally resected craniopharyngioma, the risks of radiation treatment should be clearly communicated to the patients, their families, and neurosurgeons before starting such treatment. This report expands the spectrum of reported radiation-induced neoplasms in the CNS.
authors.affiliation: Department of Neurosurgery, University of Illinois at Chicago, Illinois 60612, USA. mchan7@uic.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Chan
authors.forename: Sebastian R
authors.initials: SR
authors.lastname: Herrera
authors.forename: Sergey
authors.initials: S
authors.lastname: Neckrysh
authors.forename: Adam
authors.initials: A
authors.lastname: Wallace
authors.forename: Tibor
authors.initials: T
authors.lastname: Valyi-Nagy
authors.forename: Fady T
authors.initials: FT
authors.lastname: Charbel
mesh_terms: D000328:Adult; D003397:Craniopharyngioma / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D018242:Neuroectodermal Tumors, Primitive / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D014916:Whole-Body Irradiation / Q000009:adverse effects*