title: [Effects of Chinese herbs on glucocorticoid receptor in rat brain regions with chronic immobilization stress].
abstract: OBJECTIVE
  To investigate the changes of glucocorticoid receptor (GR) in rat brain regions with chronic immobilization stress and the influence of Chinese herbs.
  
  
  METHODS
  We copied the rat model of chronic immobilization stress (180 min daily, repeated 7 days or 21 days), and characterized the changes of GR in hippocampus CA1, cortex, dentate gyrus via immunohistochemistry integrated image analysis.
  
  
  RESULTS
  The contents of glucocorticoid receptors in hippocampus CA1 , cortex, dentate gyrus were increased and the intensity of immunity reaction was significantly stronger in the model group of 7 days than that in the normal control group (P < 0.05). The contents of GR were significantly decreased and the intensity of immunity reaction was weaken in the model group of 21 days (P < 0.05).
  
  
  CONCLUSIONS
  Compared with the model group of 21 days, the contents of GR were significantly increased and immunity reaction was intensified in three groups of treatment with Chinese herbs (P < 0.05), in which the group treated with soothing-liver herbs Xiaoyaopowder was the best.
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
authors.forename: Jia-Xu
authors.initials: JX
authors.lastname: Chen
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Zhu-Feng
authors.initials: ZF
authors.lastname: Wang
authors.forename: Guang-Xin
authors.initials: GX
authors.lastname: Yue
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000187:drug effects* / Q000378:metabolism*; D012149:Restraint, Physical; D013312:Stress, Physiological
chemical_list: D004365:Drugs, Chinese Herbal; D011965:Receptors, Glucocorticoid