title: Comparing the cochlear spiral modiolar artery in type-1 and type-2 diabetes mellitus:a human temporal bone study.
abstract: This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel x 100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.
authors.affiliation: International Hearing Foundation, Minneapolis, Minnesota 55454, USA.
authors.forename: Shin
authors.initials: S
authors.lastname: Kariya
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
authors.forename: Hisaki
authors.initials: H
authors.lastname: Fukushima
authors.forename: Norimasa
authors.initials: N
authors.lastname: Morita
authors.forename: Muzeyyen Y
authors.initials: MY
authors.lastname: Baylan
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Maeda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001158:Arteries / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D003051:Cochlea / Q000098:blood supply*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013701:Temporal Bone / Q000473:pathology*; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin