title: Substrate-specific regulation of ubiquitination by the anaphase-promoting complex.
abstract: By orchestrating the sequential degradation of a large number of cell cycle regulators, the ubiquitin ligase anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The correct timing of APC/C-dependent substrate degradation, a critical feature of progression through mitosis, was long known to be controlled by mechanisms targeting the core APC/C-machinery. Recent experiments, however, have revealed an important contribution of substrate-specific regulation of the APC/C to achieve accurate cell division. In this perspective, we describe different mechanisms of substrate-specific APC/C-regulation and discuss their importance for cell division.
authors.affiliation: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Song
authors.forename: Michael
authors.initials: M
authors.lastname: Rape
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002455:Cell Division / Q000502:physiology; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D013379:Substrate Specificity / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*; D054875:Ubiquitination / Q000502:physiology*
chemical_list: D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome