title: Hepatitis B, hepatitis C and HIV transfusion-transmitted infections in the 21st century.
abstract: In the past, transfusion-transmitted virus (TTV) infections were not uncommon. In recent years with advanced technologies and improved donor screening, the risk of viral transfusion transmission has been markedly reduced. Hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have all shown marked reduction in transmission rates. However, the newer technologies, including nucleic acid technology (NAT) testing, have affected the residual rates differently for these virally transmitted diseases. Zero risk, which has been the goal, has yet to be achieved. False negatives still persist, and transmissions of these viruses still occur, although rarely. It is known that HBV serological testing misses some infected units; likewise, HBV NAT-negative units have also been known to transmit the virus. Similarly, HIV minipool NAT-negative units have transmitted HIV, as recently as 2007; likely, these transmissions would have been prevented with single-unit NAT testing. Newer technologies, such as pathogen inactivation (PI), will (ideally) eliminate these falsely test negative components, regardless of the original testing method used for detecting the viruses.
authors.affiliation: Department of Pathology, University of California Davis Medical Center, Sacramento, CA 95817, USA. denis.dwyre@ucdmc.ucdavis.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Dwyre
authors.forename: L P
authors.initials: LP
authors.lastname: Fernando
authors.forename: P V
authors.initials: PV
authors.lastname: Holland
mesh_terms: D001782:Blood Donors; D058731:Blood Safety; D004279:DNA, Viral; D046148:Donor Selection; D015658:HIV Infections / Q000266:history / Q000517:prevention & control / Q000635:transmission*; D006509:Hepatitis B / Q000266:history / Q000517:prevention & control / Q000635:transmission*; D006526:Hepatitis C / Q000266:history / Q000517:prevention & control / Q000635:transmission*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D021141:Nucleic Acid Amplification Techniques; D065227:Transfusion Reaction
chemical_list: D004279:DNA, Viral