title: Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus.
abstract: OBJECTIVE
  The aim of the present study was to assess the prevalence of Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus -16 in oral lichen planus cases and to evaluate whether any clinical variant, histopathological or demographic feature correlates with these viruses.
  
  
  METHODS
  The study was conducted on 65 cases. Viruses were detected immunohistochemically. We evaluated the histopathological and demographic features and statistically analysed correlation of these features with Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus-16 positivity.
  
  
  RESULTS
  Herpes Simplex virus was positive in six (9%) cases and this was not statistically significant. The number of Epstein Barr virus positive cases was 23 (35%) and it was statistically significant. Human Papilloma virus positivity in 14 cases (21%) was statistically significant. Except basal cell degeneration in Herpes Simplex virus positive cases, we did not observe any significant correlation between virus positivity and demographic or histopathological features. However an increased risk of Epstein Barr virus and Human Papilloma virus infection was noted in oral lichen planus cases.
  
  
  CONCLUSIONS
  Taking into account the oncogenic potential of both viruses, oral lichen planus cases should be detected for the presence of these viruses.
authors.affiliation: Gazi University, Faculty of Dentistry, Oral Pathology Department, Ankara, Turkey.
authors.forename: Benay
authors.initials: B
authors.lastname: Yildirim
authors.forename: Burcu
authors.initials: B
authors.lastname: Sengüven
authors.forename: Cem
authors.initials: C
authors.lastname: Demir
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D006801:Humans; D017676:Lichen Planus, Oral / Q000821:virology*; D008297:Male; D008875:Middle Aged; D018139:Simplexvirus / Q000302:isolation & purification*; D055815:Young Adult