title: Innovative, non-stirred bioreactors in scales from milliliters up to 1000 liters for suspension cultures of cells using disposable bags and containers--a Swiss contribution.
abstract: Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards 'wave', or using orbital shaking to generate a 'wave' that runs round in a cylindrical container, have proved to be successful for the suspension cultures of cells, especially when combined with disposable materials. This article presents an overview of the engineering characteristics when these new principles are applied in bioreactors, and case studies covering scales of operation from milliliters to 1000 liters.
authors.affiliation: Zürcher Hochschule für Angewandte Wissenschaften, Institut für Biotechnologie, Wädenswil.
authors.forename: Sören
authors.initials: S
authors.lastname: Werner
authors.forename: Regine
authors.initials: R
authors.lastname: Eibl
authors.forename: Christine
authors.initials: C
authors.lastname: Lettenbauer
authors.forename: Marcel
authors.initials: M
authors.lastname: Röll
authors.forename: Dieter
authors.initials: D
authors.lastname: Eibl
authors.forename: Maria
authors.initials: M
authors.lastname: De Jesus
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhang
authors.forename: Matthieu
authors.initials: M
authors.lastname: Stettler
authors.forename: Stephanie
authors.initials: S
authors.lastname: Tissot
authors.forename: Cedric
authors.initials: C
authors.lastname: Bürki
authors.forename: Gilles
authors.initials: G
authors.lastname: Broccard
authors.forename: Markus
authors.initials: M
authors.lastname: Kühner
authors.forename: Rolf
authors.initials: R
authors.lastname: Tanner
authors.forename: Lucia
authors.initials: L
authors.lastname: Baldi
authors.forename: David
authors.initials: D
authors.lastname: Hacker
authors.forename: Florian M
authors.initials: FM
authors.lastname: Wurm
mesh_terms: D019149:Bioreactors; D001709:Biotechnology; D018929:Cell Culture Techniques; D004864:Equipment and Supplies; D013557:Switzerland