title: [Effect of ulinastatin on thromboxane B₂ and deep vein thrombosis in elderly patients after hip joint replacement].
abstract: OBJECTIVE
  To determine the effect of ulinastatin on plasma thromboxane B(2) and deep vein thrombosis(DVT) in elderly patients after hip joint replacement.
  
  
  METHODS
  Eighty ASAI-IIpatients aged 65-81 years undergoing hip joint replacement were randomly divided into 4 groups (n=20): Group U1 (ulinastatin 5 000 U/kg);Group U2 (ulinastatin 10 000 U/kg); Group U3 (ulinastatin 20 000 U/kg); and Group C (the same volume of saline as control).The blood samples were collected at 5 time points: preoperation (T(1)), immediately after the operation (T(2)), 1 d (T(3)), 2 d (T(4)) and 3 d after the operation (T(5)), respectively. Thromboxane B(2) was detected, and DVT was also examined through color Doppler ultrasonography 3 d after the operation.
  
  
  RESULTS
  Compared with T(1), the level of thromboxane B(2) significantly increased in Group C at T(2)-5, in Group U1 at T(2-4), in Group U2 and U3 at T(2) (P<0.01). Compared with Group C, the concentration of thromboxane B(2) decreased in Group U1 at T(2-3), in Group U2 and U3 at T(2-4) (P<0.01). Compared with Group U1, thromboxane B(2) significantly decreased in Group U2 and U3 at T(2-4) (P<0.01).The incidence rate of DVT was 40% in Group C, 10% in Group U1. There was no incidence of DVT in the Group U2 and U3 (P>0.05).
  
  
  CONCLUSIONS
  Ulinastatin can inhibit blood thromboxane B(2) level in dose dependent manner and prevent DVT in elderly patients after hip joint replacement.
authors.affiliation: Department of Anesthesiology, Ningbo 6th Hospital, Ningbo Zhejiang 315040, China. geyeying59198@163.com
authors.forename: Yeying
authors.initials: Y
authors.lastname: Ge
authors.forename: Jianqing
authors.initials: J
authors.lastname: Cheng
authors.forename: Wenjiao
authors.initials: W
authors.lastname: Xi
authors.forename: Shufen
authors.initials: S
authors.lastname: Zheng
authors.forename: Yamei
authors.initials: Y
authors.lastname: Kang
authors.forename: Yandi
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D006620:Hip Fractures / Q000601:surgery; D006801:Humans; D008297:Male; D013929:Thromboxane B2 / Q000097:blood*; D014361:Trypsin Inhibitors / Q000627:therapeutic use*; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*
chemical_list: D006023:Glycoproteins; D014361:Trypsin Inhibitors; D013929:Thromboxane B2; C028665:urinastatin