title: Body mass index and its change in adulthood and breast cancer risk in China.
abstract: OBJECTIVE
  To investigate the association between the risk of breast cancer and body mass index (BMI) and its change in adulthood.
  
  
  METHODS
  A population-based case-control study was conducted in China from 2008 to 2009. The study sample included 643 cases with pathologically-confirmed breast cancer and 590 controls. Information on adult height and weight at diagnosis, at five years before diagnosis, and at age 21 years was collected by face-to-face interview using a structured questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained using unconditional logistic regression analyses.
  
  
  RESULTS
  There was an increased risk of breast cancer associated with overweight or obesity in adulthood in Chinese women. Compared with the women who never had overweight or obesity in their adulthood, the adjusted ORs of breast cancer were 1.99 (1.42-2.79) for a BMI ≥25.0 at age 21 and just before diagnosis. This rose to 3.04 (1.18-7.86) if, in addition, BMI ≥25.0 was also present five years before diagnosis.
  
  
  CONCLUSIONS
  Weight gain throughout adulthood is associated with an increased risk of breast cancer in Chinese women.
authors.affiliation: Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: C D'Arcy
authors.initials: CD
authors.lastname: Holman
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Yuee
authors.initials: Y
authors.lastname: Teng
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D012307:Risk Factors; D011795:Surveys and Questionnaires