title: [Repeated prolonged thrombolytic therapy after unsuccessful thrombolysis in massive pulmonary embolism: a case report].
abstract: We report on a 43-year-old woman who presented with shortness of breath and syncope due to massive pulmonary embolism. Transthoracic echocardiography showed signs of right ventricular overload, and contrast-enhanced chest computed tomography demonstrated filling defects in both main pulmonary arteries consistent with obstructing thrombi. Initially, thrombolytic therapy with recombinant tissue plasminogen activator was given, but shock was not resolved. Thrombolytic therapy was repeated with streptokinase and infusion was extended to 48 hours, which yielded a successful result without any hemorrhagic complication. Repeated prolonged thrombolytic therapy after initial unsuccessful thrombolysis can be considered an alternative option in massive pulmonary embolism.
authors.affiliation: Diyarbakır Eğitim ve Araştırma Hastanesi Kardiyoloji Kliniği, Diyarbakır, Turkey. drhyazici@gmail.com
authors.forename: Hüseyin Uğur
authors.initials: HU
authors.lastname: Yazıcı
authors.forename: Burak
authors.initials: B
authors.lastname: Akçay
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tasal
authors.forename: Unal
authors.initials: U
authors.lastname: Oztürk
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D011655:Pulmonary Embolism / Q000628:therapy*; D015912:Thrombolytic Therapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents