title: Emergence of modularity and disassortativity in protein-protein interaction networks.
abstract: In this paper, we present a simple evolution model of protein-protein interaction networks by introducing a rule of small-preference duplication of a node, meaning that the probability of a node chosen to duplicate is inversely proportional to its degree, and subsequent divergence plus nonuniform heterodimerization based on some plausible mechanisms in biology. We show that our model cannot only reproduce scale-free connectivity and small-world pattern, but also exhibit hierarchical modularity and disassortativity. After comparing the features of our model with those of real protein-protein interaction networks, we believe that our model can provide relevant insights into the mechanism underlying the evolution of protein-protein interaction networks.
authors.affiliation: Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Wan
authors.forename: Shuiming
authors.initials: S
authors.lastname: Cai
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Zengrong
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D005075:Biological Evolution; D016000:Cluster Analysis; D008954:Models, Biological; D011485:Protein Binding; D025941:Protein Interaction Mapping; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins