title: [Low response rate to a vaccination against hepatitis B in patients with end-stage liver disease].
abstract: Hepatitis B vaccination was started in 41 patients with end-stage liver disease who were liver transplant candidates. Patients received three 20 microg or, starting from 1999, 40 microg doses of recombinant vaccine at 0, 2 and 4 weeks. Blood samples were obtained 4 weeks after vaccination or each revaccination; patients without protective hepatitis B surface antibodies (anti-HBs) were once or repeatedly revaccinated. Thirty-eight patients received at least 3 doses of vaccine. Protective anti-HBs level (≥ 10 IU/l) was detected in 17 of 34 patients (50 %) after the third up to eight dose. No case of chronic HBsAg carrier status was detected. Immunisation against hepatitis B in persons with liver cirrhosis is associated with a poor response and new vaccines should be considered for these patients.
authors.affiliation: Klinika Infeckcního Lékarsitví, Fakultní Nemocine Ostrava a FZS Ostravské Univerzity, Ostrava, Czech Republic. ludek.roznovsky@fnspo.cz
authors.forename: Luděk
authors.initials: L
authors.lastname: Rožnovský
authors.forename: Irena
authors.initials: I
authors.lastname: Orságová
authors.forename: Lenka
authors.initials: L
authors.lastname: Petroušová
authors.forename: Josef
authors.initials: J
authors.lastname: Tvrdík
authors.forename: Libuše
authors.initials: L
authors.lastname: Kabieszová
authors.forename: Martin
authors.initials: M
authors.lastname: Rydlo
authors.forename: Ivo
authors.initials: I
authors.lastname: Lochman
authors.forename: Alena
authors.initials: A
authors.lastname: Kloudová
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008103:Liver Cirrhosis / Q000276:immunology*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D014614:Vaccines, Synthetic; D055815:Young Adult
chemical_list: C075654:Engerix-B; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic