title: Acute oxidative stress following intravenous iron injection in patients on chronic hemodialysis: a comparison of iron-sucrose and iron-dextran.
abstract: OBJECTIVE
  Intravascular iron release from parenteral iron formulations can catalyze various harmful oxidative reactions. These topics have mainly been investigated in vivo with iron-sucrose (IS). The aim of our study was to compare IS and iron-dextran (ID) regarding iron release and induction of oxidative stress.
  
  
  METHODS
  Twenty hemodialysis patients were enrolled. Plasma iron and oxidative stress parameters were measured before and 10 min after intravenous (IV) injection of 100 mg IS and ID, respectively.
  
  
  RESULTS
  Intravascular iron increased significantly more after IS. The mean ± SD changes in plasma iron were 314 ± 172% after IS versus 90 ± 44% after ID (p < 0.001). Comparable changes in non-transferrin bound iron were 86 ± 42 versus 45 ± 45%, respectively (p < 0.05). Plasma ascorbic free radical did not change following ID (-1.8 ± 11.2%) but increased by 29 ± 31.3% after IS (p < 0.01). Further, protein carbonyls increased following IS (p < 0.05) but not after ID.
  
  
  CONCLUSIONS
  Increased oxidative stress was found only after IV injection with IS.
authors.affiliation: Departments of Molecular and Clinical Medicine and Nephrology, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. bergur.stefansson @ wlab.gu.se
authors.forename: Bergur V
authors.initials: BV
authors.lastname: Stefánsson
authors.forename: Börje
authors.initials: B
authors.lastname: Haraldsson
authors.forename: Ulf
authors.initials: U
authors.lastname: Nilsson
mesh_terms: D000328:Adult; D000368:Aged; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D000077605:Ferric Oxide, Saccharated; D005609:Free Radicals / Q000097:blood*; D005937:Glucaric Acid; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects; D006435:Renal Dialysis
chemical_list: D003911:Dextrans; D005290:Ferric Compounds; D005609:Free Radicals; D007501:Iron; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid