title: Zebrafish models of the immune response: taking it on the ChIn.
abstract: The zebrafish is proving to be an extremely versatile new experimental model for unraveling the mysteries of innate immunity and has considerable promise as a system for the identification of novel modulators of this crucial biological process. A rate-limiting factor, however, is the mechanical stimulus required to induce the inflammatory response. A new chemically induced inflammation assay ('ChIn' assay) published in BMC Biology obviates this requirement and seems set to accelerate progress in the field.
authors.affiliation: MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Renshaw
authors.forename: Philip W
authors.initials: PW
authors.lastname: Ingham
mesh_terms: D000818:Animals; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D023421:Models, Animal; D015027:Zebrafish / Q000276:immunology*