title: New lead structures in antifungal drug discovery.
abstract: During the past two decades, the incidence of invasive fungal infections has been increasing dramatically. Clinical available antifungal agents have several drawbacks such as limited potency and spectrum, drug related toxicity, non-optimal pharmacokinetics, and severe resistance. There is an emergent need to develop new antifungal drugs with novel chemical structures and novel mechanism of action. This review will focus on the most significant achievements in the discovery of antifungal lead structures within last few years. In particular, we pay more attention on the structure-activity relationship of antifungal leads and provide perspectives for future antifungal drug discovery.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
authors.forename: C
authors.initials: C
authors.lastname: Sheng
authors.forename: W
authors.initials: W
authors.lastname: Zhang
mesh_terms: D058888:14-alpha Demethylase Inhibitors / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use; D055808:Drug Discovery; D054714:Echinocandins / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D006801:Humans; D009181:Mycoses / Q000188:drug therapy*; D009285:Naphthoquinones / Q000627:therapeutic use; D058886:Sterol 14-Demethylase / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D058888:14-alpha Demethylase Inhibitors; D000935:Antifungal Agents; D002227:Carbazoles; D054714:Echinocandins; D004791:Enzyme Inhibitors; D009285:Naphthoquinones; D014230:Triazoles; D058886:Sterol 14-Demethylase; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase