title: First synthesis of C. difficile PS-II cell wall polysaccharide repeating unit.
abstract: Clostridium difficile is the most commonly diagnosed cause of nosocomial diarrhea with increasing incidence and mortality among elderly and hospitalized patients. We report the first synthesis of the surface polysaccharide PS-II repeating unit and its nonphosphorylated analogue, with a linker for conjugation, via a (4 + 2) convergent approach from a common AB(D)C tetrasaccharide intermediate.
authors.affiliation: Novartis Vaccines & Diagnostics, Vaccine Chemistry Department, Via Fiorentina 1, 53100 Siena, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Danieli
authors.forename: Luigi
authors.initials: L
authors.lastname: Lay
authors.forename: Daniela
authors.initials: D
authors.lastname: Proietti
authors.forename: Francesco
authors.initials: F
authors.lastname: Berti
authors.forename: Paolo
authors.initials: P
authors.lastname: Costantino
authors.forename: Roberto
authors.initials: R
authors.lastname: Adamo
mesh_terms: D000368:Aged; D002240:Carbohydrate Sequence; D002473:Cell Wall / Q000737:chemistry; D016360:Clostridioides difficile / Q000737:chemistry*; D003967:Diarrhea / Q000453:epidemiology*; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
chemical_list: D011135:Polysaccharides, Bacterial; C556379:polysaccharide II, Clostridium difficile