title: Therapeutic approach to multiple sclerosis by novel oral drug.
abstract: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system and the most common cause of neurological disability in young adults, along with a considerable clinical and pathological heterogeneity. Since, current therapies appear to be modest in the magnitude of their treatment effects, particularly in the progressive phase of this disease, thus novel promising therapeutic strategies might open a light horizon in approaching to an efficient treatment in MS. In this review, we will discuss about relevant patents and novel designed immunosuppressive and anti-inflammatory oral drugs promising for treatment of multiple sclerosis.
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran-14155, Box: 6446, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Jadidi-Niaragh
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
mesh_terms: D000284:Administration, Oral; D017338:Cladribine / Q000627:therapeutic use; D003437:Crotonates / Q000627:therapeutic use; D004224:Diterpenes / Q000627:therapeutic use; D004852:Epoxy Compounds / Q000627:therapeutic use; D000068876:Fingolimod Hydrochloride; D005650:Fumarates / Q000627:therapeutic use; D006801:Humans; D006885:Hydroxybutyrates; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009570:Nitriles; D010330:Patents as Topic; D010616:Phenanthrenes / Q000627:therapeutic use; D011409:Propylene Glycols / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D013110:Sphingosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014052:Toluidines / Q000627:therapeutic use
chemical_list: D003437:Crotonates; D004224:Diterpenes; D004852:Epoxy Compounds; D005650:Fumarates; D006885:Hydroxybutyrates; D009570:Nitriles; D010616:Phenanthrenes; D011409:Propylene Glycols; D015363:Quinolones; D014052:Toluidines; C001899:triptolide; C527525:teriflunomide; D017338:Cladribine; C032005:fumaric acid; C476223:laquinimod; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine