title: Oral nimodipine inhibits the ovarian cycle in mice.
abstract: Nimodipine, a calcium-channel blocker that can cross the blood-brain barrier, has been shown to inhibit pulsatile GnRH release in vitro. We now show that oral nimodipine can effectively inhibit the ovarian cycle in mice in a dose-related manner.
authors.affiliation: Toronto Centre for Advanced Reproductive Technology, Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ofer
authors.initials: O
authors.lastname: Fainaru
authors.forename: Ross
authors.initials: R
authors.lastname: Firestone
authors.forename: Robert F
authors.initials: RF
authors.lastname: Casper
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D030762:Estrous Cycle / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006727:Hormone Antagonists / Q000008:administration & dosage; D051379:Mice; D009553:Nimodipine / Q000008:administration & dosage*
chemical_list: D006727:Hormone Antagonists; D009553:Nimodipine