title: MicroRNA-related cofilin abnormality in Alzheimer's disease.
abstract: Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown. We found that microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD. These results suggest that microRNAs may play an important role in cytoskeletal pathology in AD.
authors.affiliation: Department of Neurology, Weill-Cornell Medical College, New York, New York, United States of America.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Yao
authors.forename: Tom
authors.initials: T
authors.lastname: Hennessey
authors.forename: Alex
authors.initials: A
authors.lastname: Flynt
authors.forename: Eric
authors.initials: E
authors.lastname: Lai
authors.forename: M Flint
authors.initials: MF
authors.lastname: Beal
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lin
mesh_terms: D051339:Actin Depolymerizing Factors / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism; D014176:Protein Biosynthesis
chemical_list: D051339:Actin Depolymerizing Factors; D035683:MicroRNAs