title: [Effect of substance K on the contractility of cardiomyocytes].
abstract: OBJECTIVE
  To investigate the influence and the mechanism of SK on the contractility of cultured cardiomyocytes of rats.
  
  
  METHODS
  The primary cultured single myocardial cell was treated with SK and the contraction frequency and size of cardiomyocyte were determined by a computer image analysis system. At the same time the effects of propranolol (a beta receptor antagonist), phentolamine (a alpha receptor antagonist), DSP (a tachykinin receptor antagonist) on the action of SK were investigated.
  
  
  RESULTS
  SK increased contractive extend of the cardiomyocyte, in which a dose-response relationship of SK at 1.78 x 10(-8) - 1.78 x 10(-5) mol/L exists. But the frequency of contraction did not change, pretreatment with propranolol, phentolamine had no action on the effect of SK, but DSP markedly attenuated the effects of SK.
  
  
  CONCLUSIONS
  SK may directly enhance the contractility of single cardiomyocyte, which may be related with the tachykinin receptor.
authors.affiliation: Department of Physiology, Zunyi Medical College, Guizhou 563003, China.
authors.forename: Min
authors.initials: M
authors.lastname: Cheng
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Yang
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Guo
authors.forename: Ai-Dong
authors.initials: AD
authors.lastname: Liu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001596:Benzylamines / Q000494:pharmacology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D009200:Myocardial Contraction / Q000187:drug effects*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000502:physiology; D015288:Neurokinin A / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors
chemical_list: D001596:Benzylamines; D018039:Receptors, Tachykinin; D015288:Neurokinin A; D011433:Propranolol; C012102:DSP 4; D010646:Phentolamine