title: Protective Effect of Ethanol Extract of Gymnosporia montana (Roth) Bemth. in Paracetamol-induced Hepatotoxicity in Rats.
abstract: The aim of the present study was to explore the hepatoprotective activity of the ethanol extract of leaves of Gymnosporia montana (Roth) Bemth. (Family: Celastraceous) against paracetamol-induced hepatotoxicity. Hepatotoxicity in Wistar rats was induced by a single intraperitoneal dose of 500 mg/kg of paracetamol and studied by comparing parameters such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase and histopathological examination of liver. Pre and post-treatment with ethanol extract of Gymnosporia montana (Roth) Bemth. at doses of 50 and 100 mg/kg was studied by comparing the above mentioned parameters with silymarin (100 mg/kg) as standard. Both doses of ethanol extract of Gymnosporia montana (Roth) Bemth. were found to be hepatoprotective. Extract at the dose of 100 mg/kg produced effects comparable to those of silymarin. The present study indicates that alcohol extract of Gymnosporia montana (Roth) Bemth. possessed significant hepatoprotective activity.
authors.affiliation: Department of Pharmacology, Government Medical College, Bhavnagar - 364 001, In3dia.
authors.forename: Parvati B
authors.initials: PB
authors.lastname: Patel
authors.forename: T K
authors.initials: TK
authors.lastname: Patel
authors.forename: P
authors.initials: P
authors.lastname: Shah
authors.forename: Seema N
authors.initials: SN
authors.lastname: Baxi
authors.forename: H O
authors.initials: HO
authors.lastname: Sharma
authors.forename: C B
authors.initials: CB
authors.lastname: Tripathi