title: Autoantibodies against the fibrinolytic receptor, annexin A2, in cerebral venous thrombosis.
abstract: OBJECTIVE
  Cerebral venous thrombosis (CVT) may be a manifestation of underlying autoimmune disease. Antibodies against annexin A2 (anti-A2Ab) coincide with antiphospholipid syndrome, in which antiphospholipid antibodies (aPLA) are associated with thrombosis in any vascular bed. Annexin A2, a profibrinolytic receptor and binding site for β2-glycoprotein-I, the main target for aPLA, is highly expressed on cerebral endothelium. Here we evaluate the prevalence of anti-A2Ab in CVT.
  
  
  METHODS
  Forty individuals with objectively documented CVT (33 women and 7 men) and 145 healthy controls were prospectively studied for hereditary and acquired prothrombotic risk factors, classical aPLA, and anti-A2Ab.
  
  
  RESULTS
  One or more prothrombotic risk factors were found in 85% of CVT subjects, (pregnancy/puerperium in 57.5%, classical aPLA in 22.5%, and hereditary procoagulant risk factors in 17.5%). Anti-A2Ab (titer >3 SD) were significantly more prevalent in patients with CVT (12.5%) than in healthy individuals (2.1%, P<0.01, OR, 5.9).
  
  
  CONCLUSIONS
  Anti-A2Ab are significantly associated with CVT and may define a subset of individuals with immune-mediated cerebral thrombosis.
authors.affiliation: Department of Hematology, National Cancer Institute, México City, México. gcesarman@gmail.com
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cesarman-Maus
authors.forename: Carlos
authors.initials: C
authors.lastname: Cantú-Brito
authors.forename: Fernando
authors.initials: F
authors.lastname: Barinagarrementeria
authors.forename: Rosario
authors.initials: R
authors.lastname: Villa
authors.forename: Elba
authors.initials: E
authors.lastname: Reyes
authors.forename: Jorge
authors.initials: J
authors.lastname: Sanchez-Guerrero
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Hajjar
authors.forename: Ethel Garcia
authors.initials: EG
authors.lastname: Latorre
mesh_terms: D000293:Adolescent; D000328:Adult; D017306:Annexin A2 / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005342:Fibrinolysis / Q000276:immunology*; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D055815:Young Adult
chemical_list: C472822:ANXA2 protein, human; D017306:Annexin A2; D001323:Autoantibodies; D015415:Biomarkers