title: A diagnostic and therapeutic scheme for a solitary cysticercus granuloma.
abstract: BACKGROUND
  Solitary cysticercus granuloma (SCG) is one of the most common forms of presentation of neurocysticercosis (NCC). The diagnostic workup and management approach to this condition remain uncertain and controversial.
  
  
  OBJECTIVE
  To review evidence and develop a consensus approach to the diagnosis and treatment of SCG.
  
  
  METHODS
  A multidisciplinary expert group meeting was convened in order to review and discuss various aspects of management of patients with SCG. Evidence reviewed was classified and a consensus was evolved according to standard protocols.
  
  
  RESULTS
  SCG is commonly recognized on CT as an enhancing lesion measuring <20 mm. Further evaluation with MRI does not add much information. The use of antihelminthic agents (specifically, albendazole in combination with corticosteroids) and corticosteroids alone have been shown to improve radiologic resolution and seizure outcome in patients with SCG. However, the sizes of the effects are modest. By convention, all patients with SCG presenting with seizures are initiated on antiepileptic drugs (AEDs). Available evidence suggests that withdrawal of AEDs after complete resolution of the SCG is safe. There is a high risk of seizure relapse after AED withdrawal in patients with calcific residue following resolution of the SCG. The duration of AED prophylaxis in these individuals is unclear.
  
  
  CONCLUSIONS
  It is desirable to have large, multicenter trials with sufficiently long follow-up, comparing outcomes with the use of antihelminthics with or without corticosteroids and corticosteroids alone in order to dissect out the benefits accrued due to each of these classes of drugs.
authors.affiliation: Department of Neurology, Dayanand Medical College, Ludhiana, Punjab, India
authors.forename: G
authors.initials: G
authors.lastname: Singh
authors.forename: V
authors.initials: V
authors.lastname: Rajshekhar
authors.forename: J M K
authors.initials: JM
authors.lastname: Murthy
authors.forename: S
authors.initials: S
authors.lastname: Prabhakar
authors.forename: M
authors.initials: M
authors.lastname: Modi
authors.forename: N
authors.initials: N
authors.lastname: Khandelwal
authors.forename: H H
authors.initials: HH
authors.lastname: Garcia
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000871:Anthelmintics / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000469:parasitology*; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D020019:Neurocysticercosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000469:parasitology; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000871:Anthelmintics; D000927:Anticonvulsants