title: Testosterone and growth hormone normalization: a retrospective study of health outcomes.
abstract: BACKGROUND
  Age-related declines in testosterone and growth hormone (GH) are associated with increased adiposity and decreases in lean mass and bone mineral density (BMD). A long-term retrospective study examined the effects of testosterone and/or GH supplementation on body composition and quality of life (QoL).
  
  
  METHODS
  A database survey assessed the records of 91 men and 97 women (ages 25-82) in treatment groups based on their hormonal status: dehydroepiandrosterone but no hormonal supplementation (control); testosterone only (Tes); GH only (GH); and testosterone plus GH (Tes+GH). Pre-and post-treatment assessments recorded changes in fat and lean mass, BMD, and QoL.
  
  
  RESULTS
  After an average of 3 years of treatment, weight decreased in women in the control and Tes+GH groups but remained stable in men in all groups. Tes and Tes+GH produced statistically significant increases in lean mass, reductions in fat mass, and improvements in BMD in both sexes; GH produced similar changes in women. QoL and mood improved in all groups. Treatments were generally safe and well tolerated.
  
  
  CONCLUSIONS
  In this retrospective survey, treatment with testosterone and/or GH was associated with favorable effects in men and women across a wide age range.
authors.affiliation: University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Enrique
authors.initials: E
authors.lastname: Ginzburg
authors.forename: Alvin
authors.initials: A
authors.lastname: Lin
authors.forename: Michael
authors.initials: M
authors.lastname: Sigler
authors.forename: Denise
authors.initials: D
authors.lastname: Olsen
authors.forename: Nancy
authors.initials: N
authors.lastname: Klimas
authors.forename: Alan
authors.initials: A
authors.lastname: Mintz