title: [Effect of total saponins of Panax notoginseng on urinary albumin in patients with chronic renal failure].
abstract: OBJECTIVE
  To observe the curative effect of total saponins of Panax notoginseng (PNS) on chronic renal failure (CRF).
  
  
  METHODS
  Sixty patients with CRF (non-uremic) were randomly divided into the experimental and the control groups, with 30 cases in each group. Patients in experimental group were given PNS extract Xueshuantong 0.45 g on the basis of the general symptomatic treatment, once a day. While the patients in the control group were treated with Bailing capsule of 1.0 g, three times a day. Total therapeutic courses were 2 months for both groups. The changes in renal function, hemoglobin, 24-hour urinary protein, parathyroid hormone (PTH), N-acutely-β-D-glucosaminidase (NAG) were observed in two groups.
  
  
  RESULTS
  After 2 months, the changes in serum creatinine (SCr), clearance rate of endogenous creatinine (CCr), blood urea nitrogen (BUN), uric acid (UA), hemoglobin, 24-hour urinary protein were improved in both groups, while the changes in CCr, BUN, hemoglobin, 24-hour urinary protein in the experimental group were more obvious [CCr (ml/s): 0.36±0.13 vs. 0.34±0.12, BUN (mmol/L): 15.66±9.05 vs. 20.32±8.30, hemoglobin (g/L): 101.2±9.4 vs. 95.4±8.7, 24-hour urinary protein (mg): 1 040±450 vs. 2 360±390, all P<0.05]. After treatment, NAG (U/L) were decreased significantly only in control group (18.2±9.8 vs. 28.9±12.0, P<0.05).
  
  
  CONCLUSIONS
  PNS has a good therapeutic effect for the treatment of CRF (non-uremic). It possesses such therapeutic effects as improving the renal function, and lowering urine protein.
authors.affiliation: Department of Traditional Chinese Medicine, Zhengzhou People's Hospital, Zhengzhou 450003, Henan, China.
authors.forename: Shu-ling
authors.initials: SL
authors.lastname: Peng
authors.forename: Zhao-an
authors.initials: ZA
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D053723:Panax notoginseng / Q000737:chemistry*; D008517:Phytotherapy; D012503:Saponins / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000418:Albumins; D004365:Drugs, Chinese Herbal; D012503:Saponins