title: The relevance of heat shock regulation in fungal pathogens of humans.
abstract: Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.
authors.affiliation: Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Aberdeen, UK. al.brown@abdn.ac.uk
authors.forename: Alistair J P
authors.initials: AJ
authors.lastname: Brown
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Leach
authors.forename: Susan
authors.initials: S
authors.lastname: Nicholls
mesh_terms: D002176:Candida albicans / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D018841:HSP90 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; D006360:Heat-Shock Proteins / Q000378:metabolism; D018869:Heat-Shock Response; D006801:Humans; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; C000619706:HSF1 protein, human; D018841:HSP90 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; D006360:Heat-Shock Proteins; D014157:Transcription Factors