title: Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480.
abstract: Susceptibility of clinical Mycobacterium tuberculosis isolates to PNU-100480 and linezolid was evaluated by the MGIT 960 system. The isolates had various susceptibilities to isoniazid (INH), rifampin, ethambutol, and streptomycin. The mean MIC for PNU-100480 was 3.2 times lower than that for linezolid. Therefore, PNU-100480 is a promising candidate to be developed further as an adjunct in the treatment of multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB).
authors.affiliation: Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, Netherlands. j.w.c.alffenaar@apoth.umcg.nl
authors.forename: J W C
authors.initials: JW
authors.lastname: Alffenaar
authors.forename: T
authors.initials: T
authors.lastname: van der Laan
authors.forename: S
authors.initials: S
authors.lastname: Simons
authors.forename: T S
authors.initials: TS
authors.lastname: van der Werf
authors.forename: P J
authors.initials: PJ
authors.lastname: van de Kasteele
authors.forename: H
authors.initials: H
authors.lastname: de Neeling
authors.forename: D
authors.initials: D
authors.lastname: van Soolingen
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000995:Antitubercular Agents / Q000009:adverse effects / Q000494:pharmacology*; D004977:Ethambutol / Q000494:pharmacology; D007538:Isoniazid / Q000494:pharmacology; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D023303:Oxazolidinones / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D018088:Tuberculosis, Multidrug-Resistant
chemical_list: D000081:Acetamides; D000995:Antitubercular Agents; D023303:Oxazolidinones; C543015:PNU-100480; D004977:Ethambutol; D000069349:Linezolid; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin