title: Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease.
abstract: Much evidence on the favorable effects of omega-3 ethyl esters on cardiovascular morbidity and mortality has been obtained in studies performed in healthy subjects and in different clinical settings. Here the clinical effects of omega-3 ethyl ester administration in patients with previous myocardial infarction or heart failure are reviewed, together with a discussion of underlying mechanisms of action. The pharmacokinetic and pharmacodynamic properties of omega-3 ethyl esters, as well as evidence concerning their safety and tolerability, are also reported.
authors.affiliation: Laboratory of Clinical Epidemiology of Cardiovascular Disease, Consorzio Mario Negri Sud, Chieti, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Levantesi
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Silletta
authors.forename: Roberto
authors.initials: R
authors.lastname: Marchioli