title: Prior knowledge based mining functional modules from Yeast PPI networks with gene ontology.
abstract: BACKGROUND
  In the literature, there are fruitful algorithmic approaches for identification functional modules in protein-protein interactions (PPI) networks. Because of accumulation of large-scale interaction data on multiple organisms and non-recording interaction data in the existing PPI database, it is still emergent to design novel computational techniques that can be able to correctly and scalably analyze interaction data sets. Indeed there are a number of large scale biological data sets providing indirect evidence for protein-protein interaction relationships.
  
  
  RESULTS
  The main aim of this paper is to present a prior knowledge based mining strategy to identify functional modules from PPI networks with the aid of Gene Ontology. Higher similarity value in Gene Ontology means that two gene products are more functionally related to each other, so it is better to group such gene products into one functional module. We study (i) to encode the functional pairs into the existing PPI networks; and (ii) to use these functional pairs as pairwise constraints to supervise the existing functional module identification algorithms. Topology-based modularity metric and complex annotation in MIPs will be used to evaluate the identified functional modules by these two approaches.
  
  
  CONCLUSIONS
  The experimental results on Yeast PPI networks and GO have shown that the prior knowledge based learning methods perform better than the existing algorithms.
authors.affiliation: School of Computer and Information Technology, Beijing Jiaotong University, Beijing, 100044, PR China. lpjinghk@gmail.com
authors.forename: Liping
authors.initials: L
authors.lastname: Jing
authors.forename: Michael K
authors.initials: MK
authors.lastname: Ng
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D057225:Data Mining; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005796:Genes; D025941:Protein Interaction Mapping / Q000379:methods*; D018875:Vocabulary, Controlled; D015003:Yeasts / Q000378:metabolism
chemical_list: D005656:Fungal Proteins