title: Gadoxetic acid disodium-enhanced magnetic resonance imaging for biliary and vascular evaluations in preoperative living liver donors: comparison with gadobenate dimeglumine-enhanced MRI.
abstract: OBJECTIVE
  To compare gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) with gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI in preoperative living liver donors for the evaluation of vascular and biliary variations.
  
  
  METHODS
  Sixty-two living liver donors who underwent preoperative MRI were included in this study. Thirty-one patients underwent MRI with Gd-EOB-DTPA enhancement, and the other 31 underwent MRI with Gd-BOPTA enhancement. Two abdominal radiologists retrospectively reviewed dynamic T1-weighted and T1-weighted MR cholangiography images and ranked overall image qualities for the depiction of the hepatic artery, portal vein, hepatic vein, and bile duct on a 5-point scale and determined the presence and types of normal variations in each dynamic phase. Semiquantitative analysis for bile duct visualization was also conducted by calculating bile duct-to-liver contrast ratios.
  
  
  RESULTS
  No statistical differences were found between the two contrast media in terms of hepatic artery or bile duct image quality by the two reviewers, or in terms of portal vein image quality by one reviewer (P > 0.05). Gd-BOPTA provided better image qualities than Gd-EOB-DTPA for the depiction of hepatic veins by both reviewers, and for the depiction of portal veins by one reviewer (P < 0.01). The two contrast media-enhanced images had similar bile duct-to-liver contrast ratios (P > 0.05). Regarding diagnostic accuracies with hepatic vascular/biliary branching types, no significant differences were observed between the two contrast media (P > 0.05).
  
  
  CONCLUSIONS
  Gd-EOB-DTPA could be as useful as Gd-BOPTA for the preoperative evaluation of living liver donors, and has the advantage of early hepatobiliary phase image acquisition.
authors.affiliation: Department of Radiology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Myoung Seok
authors.initials: MS
authors.lastname: Lee
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Park
authors.forename: Se Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Joon Koo
authors.initials: JK
authors.lastname: Han
authors.forename: Byung Ihn
authors.initials: BI
authors.lastname: Choi
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006499:Hepatic Artery / Q000473:pathology*; D006801:Humans; D016031:Liver Transplantation / Q000473:pathology*; D019520:Living Donors; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D018579:Patient Selection; D011300:Preoperative Care / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA