title: [Antagonist for calcium-sensing receptor. JTT-305/MK-5442].
abstract: Calcium-sensing receptor (CaSR) is a G protein-coupled receptor which was identified as a molecule that medicates the suppression of parathyroid hormone (PTH) secretion by extracellular Ca. Calcilytics are chemicals that enhance PTH secretion by antagonizing CaSR. JTT-305/MK-5442 is one of calcilytics made in Japan and is considered to be used as a bone anabolic agent through its stimulatory effect on PTH secretion. It is reported that JTT-305/MK-5442 increased lumbar bone mineral density by a placebo-controlled trial. However, further studies with more subjects are necessary to establish the clinical utility of JTT-305/MK-5442.
authors.affiliation: Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital.
authors.forename: Seiji
authors.initials: S
authors.lastname: Fukumoto
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism*; D044169:Receptors, Calcium-Sensing / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000502:physiology; D013268:Stimulation, Chemical
chemical_list: D010281:Parathyroid Hormone; D044169:Receptors, Calcium-Sensing