title: The effect of anaesthesia and aortic clamping on cardiac output measurement using arterial pulse power analysis during aortic aneurysm repair.
abstract: The LiDCO plus monitor (LiDCO Ltd, Cambridge, UK) uses pulse contour analysis of the arterial pressure waveform to indicate changes in stroke volume and cardiac output. Calibration against a lithium indicator dilution method is required to permit display of absolute values in addition to trends. The effect of haemodynamic changes during anaesthesia and surgery on this calibration factor has not previously been studied. Therefore, we investigated whether it remained constant during elective abdominal aortic aneurysm surgery in 15 patients. Comparison between the calibration factor values at different time points was made by repeated recalibration throughout the peri-operative period. Calibration factor increased by a mean of 53% after anaesthesia (epidural plus general) (p = 0.03) and decreased by a mean of 40% after aortic clamping (p = 0.0001). Recalibration should be undertaken after induction of anaesthesia and after aortic clamping if absolute values of cardiac output and stroke volume are required.
authors.affiliation: Department of Anaesthesia, Critical Care and Pain Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK. craig.beattie@luht.scot.nhs.uk
authors.forename: C
authors.initials: C
authors.lastname: Beattie
authors.forename: C
authors.initials: C
authors.lastname: Moores
authors.forename: A J
authors.initials: AJ
authors.lastname: Thomson
authors.forename: A F
authors.initials: AF
authors.lastname: Nimmo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000767:Anesthesia, Epidural / Q000379:methods; D000768:Anesthesia, General / Q000379:methods; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000494:pharmacology*; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology / Q000601:surgery*; D001794:Blood Pressure / Q000502:physiology; D002138:Calibration; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology*; D003250:Constriction; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods*
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local