title: Fixed dose (555 MBq; 15 mCi) radioiodine for the treatment of hyperthyroidism: outcome and its predictors.
abstract: Radioiodine therapy (RIT) is an accepted treatment for hyperthyroidism and a 555-MBq (15-mCi) dose is frequently used. We aimed to assess treatment outcome with this dose, and to identify predictors of successful treatment. An analysis of 478 treated patients demonstrated an overall four-month cure rate of 79.5%; success rate was higher in patients with toxic multinodular goitre, solitary toxic adenoma, a smaller thyroid or less severe disease. This information may be of further assistance if variation in the dose of RIT is considered.
authors.affiliation: Department of Nuclear Medicine and PET, John Hunter Hospital, Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales, Australia. sandeep_kr_gupta@rediffmail.com
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: McGrath
authors.forename: K
authors.initials: K
authors.lastname: Rogers
authors.forename: J
authors.initials: J
authors.lastname: Attia
authors.forename: G
authors.initials: G
authors.lastname: Lewis
authors.forename: S
authors.initials: S
authors.lastname: Viswanathan
authors.forename: M
authors.initials: M
authors.lastname: Saul
authors.forename: L
authors.initials: L
authors.lastname: Allen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes