title: Design of an in-dwelling cannula for convection-enhanced delivery.
abstract: Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.
authors.affiliation: Department of Neurosurgery, University of California San Francisco, 1855 Folsom St, MCB226, San Francisco, CA 94103-0555, USA.
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Rosenbluth
authors.forename: Matthias
authors.initials: M
authors.lastname: Luz
authors.forename: Erich
authors.initials: E
authors.lastname: Mohr
authors.forename: Stephan
authors.initials: S
authors.lastname: Mittermeyer
authors.forename: John
authors.initials: J
authors.lastname: Bringas
authors.forename: Krystof S
authors.initials: KS
authors.lastname: Bankiewicz
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002404:Catheterization / Q000295:instrumentation*; D003287:Contrast Media / Q000008:administration & dosage; D018481:Convection; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D005500:Follow-Up Studies; D005682:Gadolinium; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000008:administration & dosage; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium