title: [Hippocampal slice - a model in vitro for screening antiepileptic drugs].
abstract: OBJECTIVE
  To establish a model in vitro for screening antiepileptic drugs.
  
  
  METHODS
  Perfusing guinea pig hippocampal slice with penicillin offers a stable epileptiform discharge which was tested by two commonly clinically used antiepileptic drugs, phenytoin sodium and phenobarbital sodium at different concentration.
  
  
  RESULTS
  The experimental result showed that penicillin induced epileptiform discharge in the hippocampal slice and two antiepileptic drugs, phenytoin sodium and phenobarbital sodium inhibition of this discharge induced by penicillin.
  
  
  CONCLUSIONS
  This electrophysiological model has the advantage of simplicity, flexibility and ease of quantitation and has potential value for screen antiepileptic drugs and epilepsy research.
authors.affiliation: Department of Life Science & Biomedical Science, Zhejiang University, Hangzhou 310027, China.
authors.forename: W W
authors.initials: WW
authors.lastname: Feng
authors.forename: X C
authors.initials: XC
authors.lastname: Zhou
authors.forename: H B
authors.initials: HB
authors.lastname: Bai
authors.forename: X X
authors.initials: XX
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques
chemical_list: D000927:Anticonvulsants