title: Abnormal CEACAM6 expression in Crohn disease patients favors gut colonization and inflammation by adherent-invasive E. coli.
abstract: Abnormal expression of CEACAM6 is observed at the apical surface of the ileal epithelium in Crohn's disease (CD) patients, and CD ileal lesions are colonized by pathogenic adherent-invasive Escherichia coli (AIEC). The paper of Carvalho et al. recently reported that CD associated AIEC colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM6 acting as a receptor for type 1 pili produced by AIEC bacteria. AIEC also induce CEACAM6 expression by intestinal epithelial cells directly by adhering to host cells and indirectly via increased secretion of TNF-α from AIEC-infected macrophages. Patients expressing a basal level of CEACAM6 in ileum could be predisposed to develop ileal CD and blocking interaction between type 1 pili and CEACAM6 might serve as a specific means of disrupting the colonization and the subsequent inflammatory amplification loop.
authors.affiliation: Clermont Université, INRA, Clermont-Ferrand, France. nicolas.barnich@u-clermont1.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Barnich
authors.forename: Arlette
authors.initials: A
authors.lastname: Darfeuille-Michaud
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D001422:Bacterial Adhesion; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D003424:Crohn Disease / Q000276:immunology / Q000382:microbiology*; D004926:Escherichia coli / Q000254:growth & development / Q000472:pathogenicity*; D010861:Fimbriae, Bacterial / Q000378:metabolism; D058851:GPI-Linked Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007082:Ileum / Q000378:metabolism / Q000382:microbiology*; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008822:Mice, Transgenic; D014774:Virulence
chemical_list: D015703:Antigens, CD; C504117:CEACAM6 protein, human; D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins