title: Seroepidemiology of hepatitis A virus infection among schoolchildren in Taiwan.
abstract: Taiwan was a hyperendemic area for hepatitis A virus (HAV) infection before 1980. The aim of this study was to examine the association between seropositivity of antibodies against HAV (anti-HAV) by a community-based survey. School children from 10 elementary and 3 junior high schools, as well as staff members who worked at the above schools in central Taiwan were selected at random in this study. Anti-HAV was tested in sera of 1,954 healthy schoolchildren (aged 7-15 years old) and 254 teachers by enzyme-linked immunosorbent assay. Schoolchildren had a low prevalence of anti-HAV (2.3%) in contrast to the high seroprevalence in their teachers (52%). The seropositive rates of HAV antibody among the study subjects were increasing with age. No significant differences of anti-HAV seroprevalence among the study subjects were observed when they were stratified by gender, geographical area, household members, and parental education. Whereas, the anti-HAV seroprevalence was significantly higher in schoolchildren who were either aboriginal or living in areas without a supply of drinking tap-water. The seroprevalence of HAV data among the healthy pediatric population would be helpful to evaluate the need for mass vaccination policies.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
authors.forename: Chin-Feng
authors.initials: CF
authors.lastname: Tsai
authors.forename: Ding-Bang
authors.initials: DB
authors.lastname: Lin
authors.forename: Shiuan-Chih
authors.initials: SC
authors.lastname: Chen
authors.forename: Yih-Hsin
authors.initials: YH
authors.lastname: Chang
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Jye-Bin
authors.initials: JB
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000453:epidemiology*; D035922:Hepatitis A Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D012574:Schools; D016036:Seroepidemiologic Studies; D013624:Taiwan / Q000453:epidemiology
chemical_list: D035922:Hepatitis A Antibodies