title: B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans.
abstract: Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly.
authors.affiliation: Immunosenescence Unit, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bulati
authors.forename: Silvio
authors.initials: S
authors.lastname: Buffa
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Candore
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
authors.forename: Deborah K
authors.initials: DK
authors.lastname: Dunn-Walters
authors.forename: Mariavaleria
authors.initials: M
authors.lastname: Pellicanò
authors.forename: Yu-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Colonna Romano
mesh_terms: D000368:Aged; D000375:Aging / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D016922:Cellular Senescence; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007156:Immunologic Memory; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology
chemical_list: D007072:Immunoglobulin D; D007074:Immunoglobulin G; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7