title: Chaperoning the SNAREs: a role in preventing neurodegeneration?
abstract: Despite their potential importance as therapeutic targets, the initial events in neurodegenerative diseases are poorly understood. Emerging evidence suggests that presynaptic dysfunction might be an early event in these pathologies, and three papers now link dysregulation of SNAREprotein levels and function caused by the absence of synuclein or cysteine string protein (CSP) to activity-dependent neurodegeneration.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burgoyne
authors.forename: Alan
authors.initials: A
authors.lastname: Morgan
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D050956:HSP40 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008959:Models, Neurological; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D011485:Protein Binding; D050600:SNARE Proteins / Q000235:genetics / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics / Q000378:metabolism*; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D050956:HSP40 Heat-Shock Proteins; D008565:Membrane Proteins; D050600:SNARE Proteins; C494209:Snap25 protein, mouse; D050825:Synaptosomal-Associated Protein 25; D051844:alpha-Synuclein; C088460:cysteine string protein