title: Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents.
abstract: A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer activity. One of the compounds 4c amongst this series has shown promising anticancer activity. Further some detailed biological assays relating to the cell cycle aspects and tubulin depolymerization activity have been examined with a view to understand the mechanism of action of this conjugate.
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: E Vijaya
authors.initials: EV
authors.lastname: Bharathi
authors.forename: J Surendranadha
authors.initials: JS
authors.lastname: Reddy
authors.forename: M Janaki
authors.initials: MJ
authors.lastname: Ramaiah
authors.forename: D
authors.initials: D
authors.lastname: Dastagiri
authors.forename: M Kashi
authors.initials: MK
authors.lastname: Reddy
authors.forename: A
authors.initials: A
authors.lastname: Viswanath
authors.forename: T Lakshminarayan
authors.initials: TL
authors.lastname: Reddy
authors.forename: T Basha
authors.initials: TB
authors.lastname: Shaik
authors.forename: S N C V L
authors.initials: SN
authors.lastname: Pushpavalli
authors.forename: Manika Pal
authors.initials: MP
authors.lastname: Bhadra
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007555:Isoxazoles; D052999:Quinazolinones