title: Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: towards a multi-biomarker approach.
abstract: We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.
authors.affiliation: Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
authors.forename: M B I
authors.initials: MB
authors.lastname: Lobbes
authors.forename: M E
authors.initials: ME
authors.lastname: Kooi
authors.forename: E
authors.initials: E
authors.lastname: Lutgens
authors.forename: A W
authors.initials: AW
authors.lastname: Ruiters
authors.forename: V
authors.initials: V
authors.lastname: Lima Passos
authors.forename: S H J G
authors.initials: SH
authors.lastname: Braat
authors.forename: M
authors.initials: M
authors.lastname: Rousch
authors.forename: H
authors.initials: H
authors.lastname: Ten Cate
authors.forename: J M A
authors.initials: JM
authors.lastname: van Engelshoven
authors.forename: M J A P
authors.initials: MJ
authors.lastname: Daemen
authors.forename: S
authors.initials: S
authors.lastname: Heeneman