title: Sidestream cigarette smoke exposure effects on baroreflex in adult rats.
abstract: BACKGROUND
  It has been evidenced in the literature that exposure to cigarette smoke causes hypertension in rats; however, it has not been demonstrated if the baroreflex function is impaired before the animal becomes hypertensive.
  
  
  OBJECTIVE
  We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in Wistar normotensive rats.
  
  
  METHODS
  Rats were exposed to SSCS during three weeks, 180 minutes, five days per week, at a concentration of monoxide carbon between 100-300 ppm. Mean arterial pressure (MAP) and heart rate (HR) were evaluated through cannulation of the femoral vein and artery.
  
  
  RESULTS
  There was no significant difference between control and SSCS groups regarding basal mean arterial pressure and heart rate, sympathetic and parasympathetic components of the baroreflex function.
  
  
  CONCLUSIONS
  Our data suggest that three weeks of exposure to SSCS is not enough to significantly impair cardiovascular parameters and baroreflex sensitivity in normotensive Wistar rats.
authors.affiliation: Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP) , Rua Napoleão de Barros 715, São Paulo, SP, Brazil. valenti@unifesp.br
authors.forename: Vitor E
authors.initials: VE
authors.lastname: Valenti
authors.forename: Luiz Carlos de
authors.initials: LC
authors.lastname: Abreu
authors.forename: Celso
authors.initials: C
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution