title: Profiles of Alzheimer's disease-related pathology in an aging urban population sample in India.
abstract: Systematic studies on Alzheimer's disease (AD)-related pathology that complement clinical and epidemiological data on dementia from low and middle income countries are rare. We report the first large study on AD-related pathology in autopsy service-derived brains from an urban center in India, a low/middle income country, and compare findings with a similar sample from New York. Amyloid-β plaques and neurofibrillary tangles were assessed in 91 brain specimens derived from hospital autopsy cases from Mumbai, India (age 60+ years; mean age 71.1 years, ± 8.3 SD; range 60-107 years) and compared with identically examined age-matched sample obtained in New York. These cases had no known clinical history of dementia. Our study showed that in comparison with the New York sample, the mean brain weight of the Mumbai sample was lower (p = 0.013) and mean diffuse plaque density was higher (p = 0.019), while differences in mean density and counts of neurofibrillary tangles and neuritic plaques were not statistically significant (p > 0.05). Our findings indicate that the burden of AD-related pathology was approximately equivalent in Mumbai and New York samples, which is at variance with expected lower AD-related lesion burden based on the clinical/epidemiological studies suggesting lower prevalence of AD in India.
authors.affiliation: Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA. dushyant.purohit@mssm.edu
authors.forename: Dushyant P
authors.initials: DP
authors.lastname: Purohit
authors.forename: Nirmala O
authors.initials: NO
authors.lastname: Batheja
authors.forename: Mary
authors.initials: M
authors.lastname: Sano
authors.forename: Kusum D
authors.initials: KD
authors.lastname: Jashnani
authors.forename: Rajesh N
authors.initials: RN
authors.lastname: Kalaria
authors.forename: Arivarasan
authors.initials: A
authors.lastname: Karunamurthy
authors.forename: Shalinder
authors.initials: S
authors.lastname: Kaur
authors.forename: Asha S
authors.initials: AS
authors.lastname: Shenoy
authors.forename: Kathleen
authors.initials: K
authors.lastname: Van Dyk
authors.forename: James
authors.initials: J
authors.lastname: Schmeidler
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Perl
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D038622:Internationality; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology; D009518:New York / Q000453:epidemiology; D009929:Organ Size; D058225:Plaque, Amyloid / Q000453:epidemiology / Q000473:pathology; D014505:Urban Population