title: Non-covalent inhibitors of rhinovirus 3C protease.
abstract: The first known non-covalent inhibitors of rhinovirus 3C protease (3CP) have been identified through fragment based screening and hit identification activities.
authors.affiliation: AstraZeneca, R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Baxter
authors.forename: Mark
authors.initials: M
authors.lastname: Chambers
authors.forename: Fredrik
authors.initials: F
authors.lastname: Edfeldt
authors.forename: Karl
authors.initials: K
authors.lastname: Edman
authors.forename: Adrian
authors.initials: A
authors.lastname: Freeman
authors.forename: Cristian
authors.initials: C
authors.lastname: Johansson
authors.forename: Sarah
authors.initials: S
authors.lastname: King
authors.forename: Andy
authors.initials: A
authors.lastname: Morley
authors.forename: Jens
authors.initials: J
authors.lastname: Petersen
authors.forename: Phil
authors.initials: P
authors.lastname: Rawlins
authors.forename: Loredana
authors.initials: L
authors.lastname: Spadola
authors.forename: Bob
authors.initials: B
authors.lastname: Thong
authors.forename: Hervé
authors.initials: H
authors.lastname: Van de Poël
authors.forename: Nicola
authors.initials: N
authors.lastname: Williams
mesh_terms: D000086042:3C Viral Proteases; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D003139:Common Cold / Q000188:drug therapy / Q000821:virology; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D010850:Picornaviridae Infections / Q000188:drug therapy / Q000821:virology; D012229:Rhinovirus / Q000201:enzymology*; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D000998:Antiviral Agents; D015853:Cysteine Proteinase Inhibitors; D014764:Viral Proteins; D003546:Cysteine Endopeptidases; D000086042:3C Viral Proteases