title: Alternations of maternal and cord plasma hemostasis in preeclampsia before and after delivery.
abstract: OBJECTIVE
  The aim of this study was to investigate the role of hemostatic factors in the pathogenesis of preeclampsia.
  
  
  METHODS
  Maternal and cord plasma concentrations of tissue factor (TF), tissue factor pathway inhibitor (TFPI), von willebrand factor (vWF), soluble P-selectin (sP-selectin), fibrinopeptide A (FPA), D-dimer, and antithrombin III (AT-III) were measured by enzyme-linked immunosorbent assay (ELISA) in 46 women with preeclampsia and 40 normotensive pregnant women before and after delivery.
  
  
  RESULTS
  The maternal plasma concentrations of TF, vWF, and sP-selectin were higher, but lower concentrations of TFPI, AT-III, and D-dimer were observed in women with preeclampsia compared to normotensive pregnant women before and after delivery. Compared with maternal plasma, fetal plasma concentrations of TF concentrations were increased significantly in both groups, whereas vWF, FPA, TFPI, AT-III, and D-dimer were decreased. Compared with normotensive pregnancy, fetal plasma concentrations of TF were markedly increased in preeclampsia, accompanied with a higher vWF and a lower sP-selectin and D-dimer levels. Furthermore, fetal plasma TF concentrations were more significantly increased in women with high blood pressure and severe proteinuria.
  
  
  CONCLUSIONS
  Imbalance in the coagulation/fibrinolysis equilibrium, especially alterations in the extrinsic pathway of coagulation and anticoagulation, may play an important role in the pathogenesis of preeclampsia. In addition, fetal alteration of TF may be involved in the pathogenesis of fetal complications of preeclampsia.
authors.affiliation: Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiong
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Zhou
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.forename: Zheng-Fang
authors.initials: ZF
authors.lastname: Xu
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Lou
authors.forename: Qing-Sang
authors.initials: QS
authors.lastname: Guo
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.forename: Ting
authors.initials: T
authors.lastname: Peng
authors.forename: Duan
authors.initials: D
authors.lastname: Ma
authors.forename: Xiao-Tian
authors.initials: XT
authors.lastname: Li
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D019007:P-Selectin / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D018180:Thrombomodulin / Q000097:blood; D013925:Thromboplastin / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000097:blood; D014470:Umbilical Cord / Q000098:blood supply*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D019007:P-Selectin; D018180:Thrombomodulin; C036309:fibrin fragment D; D014841:von Willebrand Factor; D013925:Thromboplastin; D010959:Tissue Plasminogen Activator