title: LOC387761 polymorphism is associated with type 2 diabetes in the Mexican population.
abstract: Worldwide researchers have invested time, effort, and money during the last years to find new genes associated with diabetes susceptibility, such as LOC387761, HHEX, EXT2, and SLC30A8. The aim of the present study was to evaluate whether single-nucleotide polymorphisms (SNPs) of these genes are associated with type 2 diabetes (T2D) and metabolic traits in the Mexican population. We also assessed these SNPs in Mexican indigenous groups to identify a possible inherited susceptibility. Seven SNPs were analyzed in 789 Mexicans (234 control subjects, 455 type 2 diabetic patients, and 100 of indigenous origin), using the KASPar assay (KBioscience Company). Analysis of the data showed an association of the LOC387761 SNP rs7480010 with T2D (p = 0.019). The risk allele A of rs7480010 increased body mass index in diabetic patients (p = 0.01). In addition, there was no association between T2D and the SNPs of HHEX, EXT2, and SLC30A8. Our findings suggest that the SNP rs7480010 (LOC387761) can contribute to a failure in insulin secretion, thus increasing the susceptibility to T2D in Mexicans.
authors.affiliation: Facultad de Química, Universidad Nacional Autónoma de México, México, México.
authors.forename: Roxana
authors.initials: R
authors.lastname: Gutiérrez-Vidal
authors.forename: Adriana
authors.initials: A
authors.lastname: Rodríguez-Trejo
authors.forename: Samuel
authors.initials: S
authors.lastname: Canizales-Quinteros
authors.forename: Martín
authors.initials: M
authors.lastname: Herrera-Cornejo
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: Granados-Silvestre
authors.forename: Isela
authors.initials: I
authors.lastname: Montúfar-Robles
authors.forename: María Guadalupe
authors.initials: MG
authors.lastname: Ortiz-López
authors.forename: Marta
authors.initials: M
authors.lastname: Menjívar
mesh_terms: D000483:Alleles; D015992:Body Mass Index; D027682:Cation Transport Proteins / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D000078790:Insulin Secretion; D008800:Mexico; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics; D000075703:Zinc Transporter 8; D000099065:Exostosin 2
chemical_list: D027682:Cation Transport Proteins; C078492:HHEX protein, human; D018398:Homeodomain Proteins; D007328:Insulin; C492522:SLC30A8 protein, human; D014157:Transcription Factors; D000075703:Zinc Transporter 8; D017351:N-Acetylglucosaminyltransferases; D000099065:Exostosin 2