title: New genetic resources for mammalian developmental biologists.
abstract: The utilization of homologous recombination in embryonic stem cells as a means to generate mice carrying pre-determined modifications of genomic sequences has revolutionized the study of developmental biology. Recognizing the potential efficiencies that can be obtained by high-throughput production at centralized technology centers, a number of large-scale efforts for generating mice with targeted mutations have been funded. These programs are reaching fruition, and a variety of libraries of embryonic stem cells with defined mutations are now available.
authors.affiliation: Genetics Division, Brigham and Women's Hospital, Harvard Medical School New Research Building 77 Avenue Louis Pasteur, Boston, MA 02115 USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Beier