title: Nicolau livedoid dermatitis following intramuscular benzathine penicillin injection.
abstract: We report the case of a 64-year-old male presenting with a rapidly enlarging painful violaceous plaque in the left buttock and posterior thigh, following a gluteal intramuscular injection of benzathine penicillin. Associated urinary incontinence and lower left limb paresis were consistent with sciatic and lower sacral nerve damage, as confirmed by electromyography. Additional underlying muscular damage was observed in ultrasound and computer tomodensitometry scans and supported by high serum levels of creatine kinase and lactate dehydrogenase. Aggressive treatment was performed with fluid expansion, intravenous steroid bolus, vasodilators and anticoagulation, resulting in slow improvement of cutaneous and muscular lesions. However, no significant effect was observed on neurologic dysfunction after 6 months of regular neuromuscular rehabilitation. Nicolau Livedoid Dermatitis is a rare and potentially fatal condition showing variable levels of tissue impairment and unpredictable course and prognosis. Specific treatment is not consensual and the efficacy of any particular treatment remains to be established.
authors.affiliation: Serviço de Dermatologia e Venereologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Andrade
authors.forename: N
authors.initials: N
authors.lastname: Pereira
authors.forename: M M
authors.initials: MM
authors.lastname: Brites
authors.forename: M
authors.initials: M
authors.lastname: Gonçalo
authors.forename: A
authors.initials: A
authors.lastname: Figueiredo
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D001158:Arteries / Q000187:drug effects / Q000293:injuries*; D002081:Buttocks; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects*; D007511:Ischemia / Q000139:chemically induced* / Q000188:drug therapy; D008160:Lumbosacral Plexus / Q000098:blood supply / Q000293:injuries*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced*; D010291:Paresis / Q000139:chemically induced / Q000209:etiology* / Q000628:therapy; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000009:adverse effects*; D011693:Purpura / Q000139:chemically induced; D012584:Sciatic Nerve / Q000098:blood supply / Q000293:injuries*; D012867:Skin / Q000098:blood supply*; D013587:Syphilis / Q000150:complications / Q000188:drug therapy; D013848:Thigh; D014549:Urinary Incontinence / Q000139:chemically induced / Q000209:etiology* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D010401:Penicillin G Benzathine