title: [Thin layer chromatography and infrared spectroscopy in the diagnosis of salicylic intoxication].
abstract: Drugs are the main causal agents in intoxications with suicidal purpose. Salicylates are few frequently related. In this paper we reported a patient with suspicion of acute exogenous intoxication with salicylates. The patient showed clinical symptoms of fever, hypoglycemia, low cardiac rhythm, hyperventilation, pulmonary edema and coma. We employed analytical toxicology to elucidate the drug involved in the intoxication, using thin layer chromatography (TLC) and infrared spectrometry to detect acetyl salicylic acid, as the cause agent of intoxication clinical pattern, in acids extracts from urine and gastric content. The analytical results corresponds with clinical symptoms showed by the patient and the information obtained by medical monitoring of him.
authors.affiliation: Centro de Toxicología y Biomedicina (Toximed), Instituto Superior de Ciencias Médicas de Santiago de Cuba, Cuba. tito@toxi.scu.sld.cu
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Rodríguez-Tito
authors.forename: Oneyda
authors.initials: O
authors.lastname: Clapé-Laffita
authors.forename: Dayana
authors.initials: D
authors.lastname: Marín-Sánchez
authors.forename: Neyda
authors.initials: N
authors.lastname: Pérez-Garrido
authors.forename: Raúl
authors.initials: R
authors.lastname: Bonne-Hernández
mesh_terms: D002855:Chromatography, Thin Layer; D006801:Humans; D008297:Male; D011041:Poisoning / Q000175:diagnosis; D012459:Salicylates / Q000302:isolation & purification / Q000506:poisoning*; D017550:Spectroscopy, Fourier Transform Infrared; D055815:Young Adult
chemical_list: D012459:Salicylates