title: NT-pro-BNP levels as a marker of success of percutaneous transvenous mitral commissurotomy.
abstract: BACKGROUND
  Brain natriureticpeptide (BNP) levels are elevated in patients with rheumatic mitral stenosis (MS) and decrease after a successful percutaneous transvenous mitral commissurotomy (PTMC).
  
  
  METHODS
  In 37 consecutive patients of symptomatic MS (mean age 30 +/- 8.6 years) NTpro BNP levels were determined pre and 24-hours post PTMC. We seek to determine whether NT-pro-BNP levels be used as a marker of success of PTMC.
  
  
  RESULTS
  PTMC was successful orpartial successful in 33 (89 %) cases. The mean NT-pro- BNP levels decreasedfrom 771 +/- 456 pg/ml to 700 +/- 595 pg/ml (p < 0.05) following PTMC. The mean NT-pro-BNP levels decreased by 20.6% in patients with a successful PTMC and decreased by 10.8% in patients with a partially successful PTMC, while the levels increased by 33.4% in patients with an unsuccessful procedure. Patients with associated aortic regurgitation failed to show a decline in NT-pro-BNP levels despite a successful procedure.
  
  
  CONCLUSIONS
  NT-pro-BNP levels fall significantly after a successful PTMC, and a significant decrease in levels is a good marker of success of PTMC. It may not decrease in patients with associated aortic regurgitation despite a successfiul PTMC.
authors.affiliation: Department of Cardiology, All India Institute of Medical Sciences, New Delhi.
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishnan
authors.forename: Anand
authors.initials: A
authors.lastname: Agarwal
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singh
authors.forename: Ganesan
authors.initials: G
authors.lastname: Karthikeyan
authors.forename: Sandeep
authors.initials: S
authors.lastname: Seth
authors.forename: Rajiv
authors.initials: R
authors.lastname: Narang
authors.forename: Balram
authors.initials: B
authors.lastname: Bhargava
mesh_terms: D000293:Adolescent; D000328:Adult; D002404:Catheterization; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000097:blood / Q000628:therapy*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors; D016896:Treatment Outcome
chemical_list: D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain