title: Optothermophysical properties of demineralized human dental enamel determined using photothermally generated diffuse photon density and thermal-wave fields.
abstract: Noninvasive dental diagnostics is a growing discipline since it has been established that early detection and quantification of tooth mineral loss can reverse caries lesions in their incipient state. A theoretical coupled diffuse photon density and thermal-wave model was developed and applied to photothermal radiometric frequency responses, fitted to experimental data using a multiparameter simplex downhill minimization algorithm for the extraction of optothermophysical properties from artificially demineralized human enamel. The aim of this study was to evaluate the reliability and robustness of the advanced fitting algorithm. The results showed a select group of optical and thermal transport parameters and thicknesses were reliably extracted from the computational fitting algorithm. Theoretically derived thicknesses were accurately predicted, within about 20% error, while the estimated error in the optical and thermal property evaluation was within the values determined from early studies using destructive analyses. The high fidelity of the theoretical model illustrates its efficacy, reliability, and applicability toward the nondestructive characterization of depthwise inhomogeneous sound enamel and complex enamel caries lesions.
authors.affiliation: Center for Advanced Diffusion-Wave Technologies, Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario M5S 3G8, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Hellen
authors.forename: Anna
authors.initials: A
authors.lastname: Matvienko
authors.forename: Andreas
authors.initials: A
authors.lastname: Mandelis
authors.forename: Yoav
authors.initials: Y
authors.lastname: Finer
authors.forename: Bennett T
authors.initials: BT
authors.lastname: Amaechi
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003731:Dental Caries / Q000175:diagnosis* / Q000473:pathology; D003743:Dental Enamel / Q000473:pathology*; D006801:Humans; D007834:Lasers; D008962:Models, Theoretical; D015999:Multivariate Analysis; D017785:Photons; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D014070:Tooth / Q000473:pathology