title: [Association between herpetic burden and chronic ischemic heart disease: matched case-control study].
abstract: OBJECTIVE
  Previous studies showed a plausible association between herpetic burden and ischemic heart disease. Our aim is to test this hypothesis in an spanish seroepidemiological context.
  
  
  METHODS
  Sex and age matched case-control study (1:1) including patients with chronic ischemic heart disease and healthy controls. Herpetic burden was defined as the aggregate number of antibody seropositivities (IgG) for Epstein Barr Virus, cytomegalovirus, varicella zoster virus, Herpes simplex type 1 and type 2.
  
  
  RESULTS
  We found that 90.7% of cases and 70,7% of controles (P=.002), were seropositive to 4 or more herpesvirus (high herpetic burden). Within control group, hypercholesterolemic subjects had a higher proportion of high burden (88,5% vs. 61,2%, P=.02). High herpetic burden was associated with ischemic heart disease, even after adjusting for diabetes, smoking, hypertension and literacy level, (OR: 4,5 [1,23-16,53]), but not when hypercholesterolemia was included in the model (OR 2,2 [0,45-10,62]).
  
  
  CONCLUSIONS
  The hypothesized relationship is independent from most but not all classical cardiovascular risk factors.
authors.affiliation: Departamento de Medicina Preventiva, Salud Pública e Inmunología y Microbiología médicas, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, Madrid, España. jesus.esteban@urjc.es
authors.forename: Jesús
authors.initials: J
authors.lastname: Esteban-Hernández
authors.forename: Jesús
authors.initials: J
authors.lastname: San Román Montero
authors.forename: Ruth
authors.initials: R
authors.lastname: Gil
authors.forename: María
authors.initials: M
authors.lastname: Anegón
authors.forename: Angel
authors.initials: A
authors.lastname: Gil
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D004522:Educational Status; D005260:Female; D006566:Herpesviridae Infections / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D017202:Myocardial Ischemia / Q000453:epidemiology*; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012907:Smoking / Q000453:epidemiology; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G