title: Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma.
abstract: BACKGROUND
  The 14-3-3 sigma gene is transcriptionally activated by p53 after DNA damage and facilitates DNA repair during G2 arrest. The present study analyzed the clinical significance of 14-3-3 sigma expression in esophageal squamous cell carcinoma.
  
  
  METHODS
  The relationship between 14-3-3 sigma and p53 expressions was investigated immunohistochemically in surgical specimens of primary tumors from 248 patients with esophageal squamous cell carcinoma.
  
  
  RESULTS
  The positive expression rates of cytoplasmic and nuclear 14-3-3 sigma were 61.7% and 41.9%, respectively. There was no correlation between 14-3-3 sigma and p53 expression. Positive expression of nuclear 14-3-3 sigma was significantly correlated with depth of invasion, stage, lymphatic invasion, and poor prognosis. Multivariate analysis indicated that negative expression of nuclear 14-3-3 sigma was an independent prognostic factor.
  
  
  CONCLUSIONS
  Evaluation of the expression of nuclear 14-3-3 sigma proteins may be useful in predicting the outcome in patients with esophageal squamous cell carcinoma.
authors.affiliation: Department of Surgical Oncology, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan. hokumura@m.kufm.kagoshima-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okumura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kita
authors.forename: Naoya
authors.initials: N
authors.lastname: Yokomakura
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Uchikado
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Setoyama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Sakurai
authors.forename: Itaru
authors.initials: I
authors.lastname: Omoto
authors.forename: Masataka
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Owaki
authors.forename: Sumiya
authors.initials: S
authors.lastname: Ishigami
authors.forename: Shoji
authors.initials: S
authors.lastname: Natsugoe
mesh_terms: D048948:14-3-3 Proteins / Q000096:biosynthesis* / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005092:Exonucleases / Q000096:biosynthesis* / Q000235:genetics; D005095:Exoribonucleases; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics
chemical_list: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human