title: Proton pump inhibitor side effects and drug interactions: much ado about nothing?
abstract: Proton pump inhibitors (PPIs) are widely prescribed for acid-peptic disease. In general, the safety of this class of drugs has been excellent. However, in the past several years, epidemiologic studies have indicated possible risks that are biologically plausible.
authors.affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, CB #7080, Chapel Hill, NC 27599, USA. madanick@med.unc.edu
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Madanick
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000139:chemically induced / Q000453:epidemiology; D000897:Anti-Ulcer Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000077144:Clopidogrel; D004347:Drug Interactions; D005598:Fractures, Spontaneous / Q000139:chemically induced / Q000453:epidemiology; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D009393:Nephritis / Q000139:chemically induced / Q000453:epidemiology; D010024:Osteoporosis / Q000139:chemically induced / Q000453:epidemiology; D010437:Peptic Ulcer / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D011014:Pneumonia / Q000453:epidemiology; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use; D014804:Vitamin B Deficiency / Q000139:chemically induced / Q000453:epidemiology
chemical_list: D000897:Anti-Ulcer Agents; D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine