title: Hippocampal synaptic metaplasticity requires the activation of NR2B-containing NMDA receptors.
abstract: The potential to exhibit synaptic plasticity itself is modulated by previous synaptic activity, which has been termed as metaplasticity. In this paper, we demonstrated that the activation of N-methyl-d-aspartate (NMDA) receptor 2B (NR2B) subunit in NNDA receptors was required for hippocampal metaplasticity at Schaffer collateral-commissural fiber-CA1 synapses. Brief 5 Hz priming stimulation did not cause long-term synaptic plasticity; however, it could result in the inhibition of subsequently evoked long-term potentiation (LTP). Meanwhile, the application of selective antagonists for NR2B subunit of NMDA receptors after delivering priming stimulation could block the metaplasticity. In contrast, LTP induction was not affected by NR2B antagonists in slices without pre-treatment of priming stimulation. These results indicated that the activation of NR2B-containing NMDA receptors was required for metaplasticity.
authors.affiliation: Laboratory of Synaptic Signaling and Behavioral Neurosciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Liao
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Xiao
authors.forename: Qing-Shu
authors.initials: QS
authors.lastname: Lin
authors.forename: Yi-Sheng
authors.initials: YS
authors.lastname: Zhu
authors.forename: Sheng-Tian
authors.initials: ST
authors.lastname: Li
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate