title: Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma.
abstract: Gliomas are aggressive brain tumor. Association studies were consistent for an inverse association between asthma and allergic conditions (IgE levels) and risk of glioma. Studies reported that the IL-4Ra, IL-13 and STAT6 genes played a relatively strong role in IgE production or allergy. This population-based case-control study aimed to find potential association between single nucleotide polymorphisms IL-13rs20541, IL-4Rars1801275 and glioma susceptibility in population, as well as STAT6 rs1059513 and STAT6 rs324015. Among non-smokers, homozygote GG of STAT6 4610A/G showed an increased association with risk of glioma compared with AA (adjusted OR=1.691, 95%CI=1.152-2.481, p=0.007, corrected p=0.028), and the haplotype with A allele at rs1059513 and G allele at rs324015 was revealed to increase glioma risk significantly (OR=1.321,95%CI= 1.081-1.614, p=0.007,corrected p=0.028). GG genotype of STAT6 4610A/G was a significant risk factor compared with AA in glioblastoma (adjusted OR=1.856, 95%CI=1.153-2.987, p=0.011, corrected p=0.044). GG of STAT6 4610A/G was significantly related to increased WHO IV risk compared with AA (adjusted OR=1.591,95%CI=1.030-2.459, p=0.036, corrected p=0.144). Interaction between IL-13 Arg130Gln and IL-4Ra Gln576Arg was observed in decreasing glioma risk (p=0.045).
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhenchao
authors.initials: Z
authors.lastname: Ruan
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lili
authors.initials: L
authors.lastname: Yan
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fan
authors.forename: Juxiang
authors.initials: J
authors.lastname: Chen
authors.forename: Qihan
authors.initials: Q
authors.lastname: Wu
authors.forename: Ji
authors.initials: J
authors.lastname: Qian
authors.forename: Tianbao
authors.initials: T
authors.lastname: Zhang
authors.forename: KeKe
authors.initials: K
authors.lastname: Zhou
authors.forename: Yin
authors.initials: Y
authors.lastname: Mao
authors.forename: Liangfu
authors.initials: L
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
mesh_terms: D001249:Asthma / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D007073:Immunoglobulin E / Q000378:metabolism; D018793:Interleukin-13 / Q000235:genetics*; D016015:Logistic Models; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012307:Risk Factors; D050800:STAT6 Transcription Factor / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D018793:Interleukin-13; D019948:Receptors, Interleukin-4; D050800:STAT6 Transcription Factor; D007073:Immunoglobulin E