title: Transgastric transhepatic endosonography-guided biliary drainage: histological assessment of its sinus tract in an autopsy case.
abstract: Endosonography-guided biliary drainage (ESBD) is gaining attention as a promising drainage technique for obstructive jaundice. However, histological changes resulting from ESBD have not been well understood. We had an opportunity to histologically investigate the influence of ESBD, established between the left hepatic duct and the stomach, on the relevant organs in an autopsy case with bile duct cancer extending from the pancreatic head to the hepatic hilum with duodenal invasion. Localized fibrous connective tissues were present around and along the sinus tract, including the connection between the surfaces of the left lobe of the liver and the gastric serosa, without hemorrhage, inflammatory changes, or cancer invasion. The inside of the ESBD stent was slightly stenotic at the intramural portion of the stomach due to proliferation of granulation tissue. No bile stasis or abscess was observed in the left lobe. These results are quite suggestive of the high safety and efficacy of ESBD with adequate performance.
authors.affiliation: Department of Gastroenterology, Sendai City Medical Center, Sendai, Japan. noda@openhp.or.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Noda
authors.forename: Naotaka
authors.initials: N
authors.lastname: Fujita
authors.forename: Go
authors.initials: G
authors.lastname: Kobayashi
authors.forename: Kei
authors.initials: K
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Obana
authors.forename: Jun
authors.initials: J
authors.lastname: Horaguchi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Koshita
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Kanno
authors.forename: Takashi
authors.initials: T
authors.lastname: Sawai
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001344:Autopsy; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D002423:Cause of Death; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000473:pathology*; D004322:Drainage / Q000379:methods; D004379:Duodenal Neoplasms / Q000473:pathology*; D019160:Endosonography; D005260:Female; D006801:Humans; D008100:Liver Abscess / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D018805:Sepsis; D015607:Stents