title: Palm olein and olive oil cause a higher increase in postprandial lipemia compared with lard but had no effect on plasma glucose, insulin and adipocytokines.
abstract: Postprandial lipemia impairs insulin sensitivity and triggers the pro-inflammatory state which may lead to the progression of cardiovascular diseases. A randomized, crossover single-blind study (n = 10 healthy men) was designed to compare the effects of a high-fat load (50 g fat), rich in palmitic acid from both plant (palm olein) or animal source (lard) versus an oleic acid-rich fat (virgin olive oil) on lipemia, plasma glucose, insulin and adipocytokines. Serum triacylglycerol (TAG) concentrations were significantly lower after the lard meal than after the olive oil and palm olein meals (meal effect P = 0.003; time effect P < 0.001). The greater reduction in the plasma non-esterified free fatty acids levels in the lard group compared to the olive oil meal was mirrored by the changes observed for serum TAG levels (P < 0.05). The magnitude of response for plasma glucose, insulin and adipocytokines [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and leptin] were not altered by the type of dietary fats. A significant difference in plasma IL-1β was found over time following the three high fat loads (time effect P = 0.036). The physical characteristics and changes in TAG structure of lard may contribute to the smaller increase in postprandial lipemia compared with palm olein. A high fat load but not the type of fats influences concentrations of plasma IL-1β over time but had no effect on other pro-inflammatory markers tested in the postprandial state.
authors.affiliation: Food Technology and Nutrition Unit, Product Development and Advisory Services, Malaysian Palm Oil Board, Kajang, Selangor, Malaysia. kt.teng@gmail.com
authors.forename: Kim-Tiu
authors.initials: KT
authors.lastname: Teng
authors.forename: Gowri
authors.initials: G
authors.lastname: Nagapan
authors.forename: Hwee Ming
authors.initials: HM
authors.lastname: Cheng
authors.forename: Kalanithi
authors.initials: K
authors.lastname: Nesaretnam
mesh_terms: D054392:Adipokines / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D007328:Insulin / Q000097:blood*; D008297:Male; D000069463:Olive Oil; D000073878:Palm Oil; D010938:Plant Oils / Q000008:administration & dosage*; D019518:Postprandial Period; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D000069463:Olive Oil; D010938:Plant Oils; D000073878:Palm Oil; C029310:lard