title: Aggressive systemic mastocytosis associated with mesangioproliferative glomerulonephritis.
abstract: OBJECTIVE
  Aggressive systemic mastocytosis (ASM) is a subtype of systemic mastocytosis, which comprises a heterogenous group of disorders characterized by infiltration of bone marrow, skin, liver, spleen, lymph nodes and gastrointestinal tract by neoplastic mast cells. There is lack of data on the association of ASM with renal involvement, as kidney is not among the known organs affected by ASM.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first case of ASM associated with mesangioproliferative glomerulonephritis and monoclonal gammopathy of undetermined significance, without the presence of nephrotic syndrome. The patient's clinical course and the intriguing family history, along with the treatment selection are described. Finally, the proposed possible pathophysiological mechanisms explaining the renal involvement of our patient are discussed.
authors.affiliation: Department of Haematology, Aristotle University of Thessaloniki, AHEPA Hospital, Greece. diamantidis79@yahoo.gr
authors.forename: Michael D
authors.initials: MD
authors.lastname: Diamantidis
authors.forename: Athena D
authors.initials: AD
authors.lastname: Myrou
authors.forename: Georgia D
authors.initials: GD
authors.lastname: Kaiafa
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Kaloutsi
authors.forename: Georgia
authors.initials: G
authors.lastname: Karayannopoulou
authors.forename: Andreas
authors.initials: A
authors.lastname: Theodoridis
authors.forename: Alexandra
authors.initials: A
authors.lastname: Adamidou
authors.forename: Athanasios
authors.initials: A
authors.lastname: Papadopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Grekas
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D034721:Mastocytosis, Systemic / Q000175:diagnosis* / Q000628:therapy; D050527:Mesangial Cells / Q000473:pathology*; D008998:Monoclonal Gammopathy of Undetermined Significance