title: Multiple cerebral infarction and cardiomyopathy with pheochromocytoma.
abstract: A 44-year-old woman was admitted to our hospital with altered mental status and weakness in the left upper and lower limbs. A brain magnetic resonance imaging indicated multiple cerebral infarctions in the bilateral frontal and parietal lobes and in the left occipital lobe. Magnetic resonance angiography indicated overall arterial wall irregularity and stenosis. An electrocardiogram showed negative T waves, troponin I was elevated at 0.60 ng/mL, and an echocardiogram showed severe hypokinesis, leading to a diagnosis of ischemic heart disease; however, no stenosis was found at cardiac catheterization. No other etiology for the angiopathy could be found. Whole-body computed tomography demonstrated an adrenal tumor and urinary catecholamine levels were elevated. Following excision of the adrenal tumor, a diagnosis of pheochromocytoma was made. Postoperatively, the patient's arterial stenosis and cardiac abnormalities improved. It was hypothesized that the patient's cardiomyopathy and vasospasm were secondary to excessive catecholamine secretion from the pheochromocytoma.
authors.affiliation: Department of Neurology, Yokohama City University School of Medicine, Yokohama, Japan. uedan@ck49.so-net.ne.jp
authors.forename: Naohisa
authors.initials: N
authors.lastname: Ueda
authors.forename: Shinobu
authors.initials: S
authors.lastname: Satoh
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kuroiwa
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000503:physiopathology; D000328:Adult; D009202:Cardiomyopathies / Q000209:etiology* / Q000503:physiopathology; D002395:Catecholamines / Q000097:blood; D002544:Cerebral Infarction / Q000209:etiology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D038524:Diffusion Magnetic Resonance Imaging; D004562:Electrocardiography; D005260:Female; D006801:Humans; D010673:Pheochromocytoma / Q000150:complications* / Q000503:physiopathology
chemical_list: D002395:Catecholamines