title: Selected human leukocyte antigen class II polymorphisms and risk of adult glioma.
abstract: Few studies have examined the relationship between human leukocyte antigen (HLA) polymorphisms and adult glioma, particularly at class II loci. We evaluated the association between selected HLA class II polymorphisms and adult glioma in a large, hospital-based case-control study, using unconditional logistic regression. DQB1 06 (OR=1.67, 95% CI=1.17-2.39) and DRB1 13 (OR=1.69, 95% CI=1.08-2.64) alleles were associated with an increased risk of glioma, while the DQB1 05 allele showed an inverse association (OR=0.63, 95% CI=0.43-0.93). These results, which were of borderline significance once controlled for the false discovery rate, suggest a potential role for the DQB1 06, DQB1 05, and DRB1 13 alleles in glioma susceptibility.
authors.affiliation: Yale School of Public Health, Yale School of Medicine, 60 College Street, P.O. Box 208034, New Haven, CT 06510, USA.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Bassig
authors.forename: Peter D
authors.initials: PD
authors.lastname: Inskip
authors.forename: Laurie
authors.initials: L
authors.lastname: Burdette
authors.forename: William R
authors.initials: WR
authors.lastname: Shapiro
authors.forename: Robert G
authors.initials: RG
authors.lastname: Selker
authors.forename: Howard A
authors.initials: HA
authors.lastname: Fine
authors.forename: Jay S
authors.initials: JS
authors.lastname: Loeffler
authors.forename: Peter M
authors.initials: PM
authors.lastname: Black
authors.forename: Robert
authors.initials: R
authors.lastname: Dubrow
authors.forename: Alina V
authors.initials: AV
authors.lastname: Brenner
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005910:Glioma / Q000235:genetics* / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000276:immunology
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains