title: [Effects of cold-stress stimulation on filial growth and development of pregnant mice].
abstract: OBJECTIVE
  To inspect the effects of cold-stress on filial growth and development of pregnant mice.
  
  
  METHODS
  Pregnant mice were divided into pregnant control group(PN) and pregnant cold-stress group (PC). The PC were kept in (4 +/- 2) C from 8:00 to 12:00 every day and the PN were kept in 25 degrees C. After 18 days, the blood pressure of pregnant mice were measured, and the weight of fetus, placenta and amniotic fluid were recorded. The natal mice visceral organs weight, visceral organs weight and body weight ratio were also measured. Growth curve and increment ratio curve of body weight were protracted every day from 1 st day to 44th day. Blood pressure of all filiality were measured in 8 weeks after they were born.
  
  
  RESULTS
  The blood pressure in PC was increased than that in PN (P < 0.05), the weight of fetus, placenta and amniotic fluid of PC decreased significantly compared with PN (P < 0.01). The filial visceral organ weight of PC reduced obviously compared with PN (P < 0.05), while the visceral organs weight and body weight ratio had no statistical meanings between the offspring of PC and PN (P > 0.05). Obvious difference of growth curve of the two filial groups was also existed until sexual maturity, but increment ratio curve of body weight of the two filial groups was basically fitted close. Filial blood pressure of PC was evidently higher than that in PN.
  
  
  CONCLUSIONS
  Cold-stress stimulations seriously affect filial growth and development of pregnant mice.
authors.affiliation: Department of Biology, Huaiyin Teachers college, Huai'an 223300, China.
authors.forename: Zheng-jun
authors.initials: ZJ
authors.lastname: Pan
authors.forename: Zhong-ke
authors.initials: ZK
authors.lastname: Chen
mesh_terms: D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D046110:Hypertension, Pregnancy-Induced / Q000209:etiology*; D008297:Male; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013312:Stress, Physiological / Q000502:physiology*