title: [Fusarium solani infection in a patient after allogeneic hematopoietic stem cell transplantation: case report and literature review].
abstract: OBJECTIVE
  To study Fusarium solani infection as a complication in patients after allogeneic hematopoietic stem cell transplantation and to discuss the diagnosis and appropriate therapy.
  
  
  METHODS
  Symptoms, physical examination, laboratory tests, computed tomographic (CT) scans, treatments and outcomes of Fusarium solani infection in a patient with acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation were retrospectively analyzed, and related literatures reviewed.
  
  
  RESULTS
  The patient developed pulmonary infiltration and systemic multiple subcutaneous masses after allogeneic hematopoietic stem cell transplantation. Tissue biopsy smear showed a large number of hyphae and spores, and fungal culture grew Fusarium solani. The subcutaneous masses were incised and drained, while amphotericin B and voriconazole were administered, with granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) for hematopoietic recovery. The patient was discharge after full recovery.
  
  
  CONCLUSIONS
  Fusarium solani infection is a rare but fatal complication after allogeneic hematopoietic stem cell transplantation. Once the skin lesions or subcutaneous masses developed, tissue smear and culture should be done as soon as possible. Early diagnosis and effective treatment to recovery of the patient after allogeneic hematopoietic stem cell transplant. Moreover, the recovery of adequate neutrophil levels is the most important factor in the resolution of fusarial infection.
authors.affiliation: Hematopoietic Stem Cell Transplantation Center of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, China.
authors.forename: Jiang-Wei
authors.initials: JW
authors.lastname: Hu
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Shu
authors.forename: Jing
authors.initials: J
authors.lastname: Ren
authors.forename: Xiu-Yun
authors.initials: XY
authors.lastname: Yin
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Liang-Ding
authors.initials: LD
authors.lastname: Hu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Hu
authors.initials: H
authors.lastname: Chen
mesh_terms: D060585:Fusariosis / Q000175:diagnosis* / Q000188:drug therapy; D005670:Fusarium / Q000472:pathogenicity*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D014184:Transplantation, Homologous