title: Local transplantation of G-CSF-mobilized CD34(+) cells in a patient with tibial nonunion: a case report.
abstract: Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34(+) cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been  reported. Here, we report the first case of tibial nonunion receiving autologous, granulocyte colony stimulating factor mobilized CD34(+) cells accompanied with autologous bone grafting. No serious adverse event occurred, and the novel therapy performed 9 months after the primary  operation resulted in bone union 3 months later without any symptoms including pain and gait disturbance.
authors.affiliation: Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan. kurodar@med.kobe-u.ac.jp
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kuroda
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Miwa
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Kawamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Mifune
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fukui
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Takahiro
authors.initials: T
authors.lastname: Niikura
authors.forename: Sang Yang
authors.initials: SY
authors.lastname: Lee
authors.forename: Keisuke
authors.initials: K
authors.lastname: Oe
authors.forename: Taro
authors.initials: T
authors.lastname: Shoji
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kuroda
authors.forename: Miki
authors.initials: M
authors.lastname: Horii
authors.forename: Ayumi
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ono
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Koibuchi
authors.forename: Shin
authors.initials: S
authors.lastname: Kawamata
authors.forename: Masanori
authors.initials: M
authors.lastname: Fukushima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kurosaka
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asahara
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism*; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000628:therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D019990:Perioperative Care; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D018952:Antigens, CD34; D016179:Granulocyte Colony-Stimulating Factor