title: Breast cancer after bilateral risk-reducing mastectomy.
abstract: This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.
authors.affiliation: Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark. Anne-Bine.Skytte@slb.regionsyddanmark.dk
authors.forename: A-B
authors.initials: AB
authors.lastname: Skytte
authors.forename: D
authors.initials: D
authors.lastname: Crüger
authors.forename: M
authors.initials: M
authors.lastname: Gerster
authors.forename: A-V
authors.initials: AV
authors.lastname: Laenkholm
authors.forename: C
authors.initials: C
authors.lastname: Lang
authors.forename: K
authors.initials: K
authors.lastname: Brøndum-Nielsen
authors.forename: M K
authors.initials: MK
authors.lastname: Andersen
authors.forename: L
authors.initials: L
authors.lastname: Sunde
authors.forename: S
authors.initials: S
authors.lastname: Kølvraa
authors.forename: A-M
authors.initials: AM
authors.lastname: Gerdes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000601:surgery*; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D009154:Mutation; D040242:Risk Reduction Behavior; D055815:Young Adult