title: Inflammation, HIF-1, and the epigenetics that follows.
abstract: We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequences of these changes are depicted in terms of gene expression and cellular phenotypes. We finally integrate available data to introduce novel speculations on the relationship between inflammation, histones, and DNA function and integrity.
authors.affiliation: Tumor Genetics Laboratory, National Institute for Cancer Research, Largo Benzi, 10, 16132 Genova, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Brigati
authors.forename: Barbara
authors.initials: B
authors.lastname: Banelli
authors.forename: Angela
authors.initials: A
authors.lastname: di Vinci
authors.forename: Ida
authors.initials: I
authors.lastname: Casciano
authors.forename: Giorgio
authors.initials: G
authors.lastname: Allemanni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Forlani
authors.forename: Luana
authors.initials: L
authors.lastname: Borzì
authors.forename: Massimo
authors.initials: M
authors.lastname: Romani
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D056466:Histone Demethylases / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism; D051793:Hypoxia-Inducible Factor 1 / Q000096:biosynthesis / Q000235:genetics*; D007249:Inflammation / Q000235:genetics* / Q000378:metabolism
chemical_list: D006657:Histones; D051793:Hypoxia-Inducible Factor 1; D056466:Histone Demethylases