title: [The role of diffusion 3-Tesla MRI in detecting prostate cancer before needle biopsy: multiparametric study of 111 patients].
abstract: OBJECTIVE
  Evaluate diffusion MRI in the multiparametric assessment of prostate cancer before needle biopsy.
  
  
  METHODS
  One hundred eleven patients with suspected prostate cancer (mean age: 63 years old, median PSA: 7 ng/mL) were examined before undergoing needle biopsy (59 patients with a history of a negative biopsy and 52 without a history of biopsy). A diffusion sequence type SS SE-EPI (TR/TE: 5357/58, fEPI: 73, b 0 and 1000 s/mm², axial) with a qualitative analysis of the ADC map was performed in addition to T2 and T1 gadolinium enhanced sequences on 3 T MRI with an endorectal coil. The histological correlations were obtained by ultrasound guided needle biopsy (85 patients) or radical prostatectomy (26 patients).
  
  
  RESULTS
  The correlation of the results of the diffusion sequence in the series of the 111 patients and the biopsies of the entire prostate or the hemiprostate had a sensitivity of: 92%, 77%; a specificity of: 55%, 70%; a positive predictive value of: 77%, 62%; a negative predictive value of: 84%, 80% and an efficacy of 78%, 75% respectively. The agreement of the three sequences had a specificity of 84.3%.
  
  
  CONCLUSIONS
  The sensitivity of diffusion MRI is high for the detection of cancer of the prostate. Specificity of sequences is good. The results of simple visual assessment of the ADC map are good.
authors.affiliation: Service de Radiologie B, Hopitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, 1 Place de l'Hôpital, BP 426, 67091 Strasbourg Cedex. catherine.roy@chru-strasbourg.fr
authors.forename: C
authors.initials: C
authors.lastname: Roy
authors.forename: R
authors.initials: R
authors.lastname: Pasquali
authors.forename: A
authors.initials: A
authors.lastname: Matau
authors.forename: G
authors.initials: G
authors.lastname: Bazille
authors.forename: H
authors.initials: H
authors.lastname: Lang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle; D015331:Cohort Studies; D003287:Contrast Media / Q000008:administration & dosage; D038524:Diffusion Magnetic Resonance Imaging; D019160:Endosonography; D005682:Gadolinium; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media; D005682:Gadolinium; D017430:Prostate-Specific Antigen