title: A cell kinetic model of granulopoiesis under radiation exposure: extension from rodents to canines and humans.
abstract: As significant ionising radiation exposure will occur during prolonged space travel in future, it is essential to understand their adverse effects on the radiosensitive organ systems that are important for immediate survival of humans, e.g. the haematopoietic system. In this paper, a biomathematical model of granulopoiesis is used to analyse the granulocyte changes seen in the blood of mammalians under acute and continuous radiation exposure. This is one of a set of haematopoietic models that have been successfully utilised to simulate and interpret the experimental data of acute and chronic radiation on rodents. Extension to canine and human systems indicates that the results of the model are consistent with the cumulative experimental and empirical data from various sources, implying the potential to integrate them into one united model system to monitor the haematopoietic response of various species under irradiation. The suppression of granulocytes' level of a space traveller under chronic stress of low-dose irradiation as well as the granulopoietic response when encountering a historically large solar particle event is also discussed.
authors.affiliation: Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA. shaowen.hu-1@nasa.gov
authors.forename: Shaowen
authors.initials: S
authors.lastname: Hu
authors.forename: Francis A
authors.initials: FA
authors.lastname: Cucinotta
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006098:Granulocytes / Q000502:physiology* / Q000528:radiation effects*; D006801:Humans; D007700:Kinetics; D019891:Leukopoiesis / Q000502:physiology* / Q000528:radiation effects*; D051379:Mice; D008954:Models, Biological; D011829:Radiation Dosage; D051381:Rats; D012993:Solar Energy; D013045:Species Specificity