title: Enantioselective total synthesis of (+)-salvileucalin B.
abstract: An enantioselective total synthesis of the diterpenoid natural product (+)-salvileucalin B is reported. Key findings include a copper-catalyzed arene cyclopropanation reaction to provide the unusual norcaradiene core and a reversible retro-Claisen rearrangement of a highly functionalized norcaradiene intermediate.
authors.affiliation: The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
authors.forename: Sergiy
authors.initials: S
authors.lastname: Levin
authors.forename: Roger R
authors.initials: RR
authors.lastname: Nani
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Reisman
mesh_terms: D003521:Cyclopropanes / Q000737:chemistry; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D003521:Cyclopropanes; D004224:Diterpenes; C533291:salvileucalin B; C030797:cyclopropane