title: [The roles of carbon monoxide on hypoxic pulmonary vasoconstriction].
abstract: OBJECTIVE
  To study the roles of carbon monoxide on hypoxic pulmonary vasoconstriction (HPV) by investigating the effects of exogenous carbon monoxide and heme oxygenase inhibitor ZnPPIX on hypoxic vasoconstriction reaction of isolated rat pulmonary arterial rings (PAR).
  
  
  RESULTS
  Hypoxia caused constriction in PAR preconstricted by PE. Both ZnPPIX and carbon monoxide inhibited hypoxic pulmonary constriction significantly by increasing the cGMP level after hypoxia.
  
  
  CONCLUSIONS
  ZnPPIX and exogenous carbon monoxide can inhibit HPV. The reduction of cGMP induced by the decreased of CO may be one of reasons of HPV.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Ding
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Liu
authors.forename: Zhuo-Ren
authors.initials: ZR
authors.lastname: Sheng
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000502:physiology*; D000860:Hypoxia; D066298:In Vitro Techniques; D008297:Male; D011651:Pulmonary Artery / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000502:physiology*
chemical_list: D002248:Carbon Monoxide