title: Modulation of exteroceptive suppression periods in human jaw-closing muscles by subanaesthetic dose of propofol.
abstract: Exteroceptive suppression (ES) periods in human jaw-closing muscles can be conditioned by a wide range of somatosensory stimuli and cognitive states. The aim of this study was to examine the effects of subanaesthetic doses of midazolam, ketamine and propofol on the short latency (ES1) and long latency (ES2) reflex in the jaw-closing muscles. First, we tried to evaluate the various methodological criteria for ES recording. We then examined the effect of subanaesthetic doses of midazolam (0·035 mg kg(-1)), ketamine (0·30 mg kg(-1)) and propofol (0·35 mg kg(-1)) on these reflexes of recording left masseter and temporalis muscle. ES duration did not differ greatly in the present study, recorded with the correct adjustment of stimulating and recording conditions. None of the subanaesthetic doses of the agents influenced ES1, and no significant effects on ES2 were observed with midazolam and ketamine. However, significant inhibitory change was observed in ES2 with propofol. ES2 is thought to be mediated by afferents, which descend in the spinal trigeminal tract and connect with a polysynaptic chain of excitatory interneurones located in the lateral reticular formation. Our observations indicate that propofol is uniquely effective not only through involvement of the gamma-aminobutyric acid type A receptor, but also through a range of other effects.
authors.affiliation: Department of Dental Anesthesiology, Kagoshima University of Medical and Dental Hospital, Kagoshima, Japan. toyosato21@xc4.so-net.ne.jp
authors.forename: A
authors.initials: A
authors.lastname: Toyosato
authors.forename: M
authors.initials: M
authors.lastname: Begum
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: G
authors.initials: G
authors.lastname: Someya
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D001732:Bite Force; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology; D008406:Masseter Muscle / Q000187:drug effects* / Q000502:physiology; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D018079:Receptors, GABA / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D018709:Statistics, Nonparametric; D013703:Temporal Muscle / Q000187:drug effects* / Q000502:physiology; D014278:Trigeminal Nuclei / Q000502:physiology; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine; D008874:Midazolam; D015742:Propofol