title: [Activation of periphery group III metabotropic glutamate receptors inhibits formalin-induced activation of spinal p38-MAPK in rats].
abstract: OBJECTIVE
  To explore the effects of periphery injection of L-SOP on the activation of p38MAPK in spinal cord in formalin pain model in rats.
  
  
  METHODS
  Fourty-eight male Wistar rats were divided randomly into four groups (n=12): NS group and three different dose of L-SOP groups. For each group, 6 rats used to observe flinching and licking time every as nociception behavior 3 minutes in 1 hour after formalin injected and the other 6 rats used to observe the activation of p38(P-p38) by Western blotting.
  
  
  RESULTS
  All the three different groups of L-SOP could inhibit nociception behavior in the tonic phase,and 250 nmoVl/L and 500 nmol/L groups could suppress not only in the tonic phase but also in the acute phase. 250 nmol/L and 500 nmol/L groups could reduce activated or phosphorylated p38MAPK in spinal cord.
  
  
  CONCLUSIONS
  Periphery injection of L-SOP can reduce nociceptive behavior and phosphorylated p38MAPK in the spinal cord in formalin-induced hyperalgia, it is suggested that there is functional expression of mGluRs III in the periphery and is involved in the processing of peripheral noxious informations.
authors.affiliation: Department of Anesthesiology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Yan
authors.forename: Zhi-feng
authors.initials: ZF
authors.lastname: Peng
authors.forename: Xiao-rong
authors.initials: XR
authors.lastname: Yang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Nai-hong
authors.initials: NH
authors.lastname: Liu
authors.forename: Xing
authors.initials: X
authors.lastname: Jin
authors.forename: Qiao
authors.initials: Q
authors.lastname: Cheng
authors.forename: Ce
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005557:Formaldehyde; D008297:Male; D059225:Nociception / Q000502:physiology; D010146:Pain / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D010768:Phosphoserine / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*; D013116:Spinal Cord / Q000378:metabolism* / Q000503:physiopathology; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D018094:Receptors, Metabotropic Glutamate; C102718:metabotropic glutamate receptor 3; D010768:Phosphoserine; D005557:Formaldehyde; D048051:p38 Mitogen-Activated Protein Kinases