title: Mitral annular longitudinal function preservation after mitral valve repair: the MARTE study.
abstract: BACKGROUND
  In patients with chronic mitral regurgitation (MR), undergoing surgical mitral valve repair, current Guidelines only recommend standard echocardiographic indices i.e. left ventricular (LV) ejection fraction (EF), and LV end-systolic and end-diastolic diameters as preoperative variables. However LV EF is often preserved until advanced stages of the valve disease. Aim of this study was to evaluate changes in LV systolic longitudinal function, 3 months after mitral valve repair in patients with chronic degenerative MR and normal preoperative EF.
  
  
  METHODS
  We measured M-mode mitral lateral annulus systolic excursion (MAPSE) and Tissue Doppler (TD) peak systolic annular velocity (S(m)) in 31 patients with moderate to severe MR and normal EF (59.9 ± 4.7%) candidates for mitral valve repair, preoperatively and 3 months after surgery.
  
  
  RESULTS
  After mitral valve repair, S(m) increased from 7.8 ± 1.4 to 9.6 ± 2.2 cm/s (p<0.0001) and MAPSE increased from 1.33 ± 0.26 to 1.55 ± 0.25 cm (p=0.0013). EF decreased from 59.9 ± 4.7 to 51.3 ± 5.9% (p<0.0001). As expected, LV diameters and volumes, wall thicknesses, midwall fractional shortening (mFS), and left atrial (LA) size were all reduced after surgery.
  
  
  CONCLUSIONS
  This study suggests that assessment of LV long axis systolic velocity and amplitude of excursion by echocardiography is more sensitive than simple determination of EF for revealing the beneficial impact of MR surgery on overall systolic function.
authors.affiliation: Department of Cardiovascular Disease, University of Siena, Italy. matteo.lisi@hotmail.it
authors.forename: M
authors.initials: M
authors.lastname: Lisi
authors.forename: P
authors.initials: P
authors.lastname: Ballo
authors.forename: M
authors.initials: M
authors.lastname: Cameli
authors.forename: F
authors.initials: F
authors.lastname: Gandolfo
authors.forename: M
authors.initials: M
authors.lastname: Galderisi
authors.forename: M
authors.initials: M
authors.lastname: Chiavarelli
authors.forename: M Y
authors.initials: MY
authors.lastname: Henein
authors.forename: S
authors.initials: S
authors.lastname: Mondillo
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D020127:Recovery of Function / Q000502:physiology*; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology*