title: Measurement of cerebral blood flow responses to the thigh cuff maneuver: a comparison of TCD with a novel MRI method.
abstract: Cerebral autoregulation (CA) describes the mechanism responsible for maintaining cerebral blood flow (CBF) relatively constant, despite changes in mean arterial blood pressure (ABP). This paper introduces a novel method for assessing CA using magnetic resonance imaging (MRI). Images are rapidly and repeatedly acquired using a gradient-echo echo-planar imaging pulse sequence for a period of 4 minutes, during which a transient decrease in ABP is induced by rapid release of bilateral thigh cuffs. The method was validated by comparing the observed MRI signal intensity change with the CBF velocity change in the middle cerebral arteries, as measured by transcranial Doppler (TCD) ultrasound, using a standardized thigh cuff maneuver in both cases. Cross-correlation analysis of the response profiles from the left and right hemispheres showed a greater consistency for MRI measures than for TCD, both for interhemisphere comparisons and for repeated measures. The new MRI method may provide opportunities for assessing regional autoregulatory changes following acute stroke, and in other conditions in which poor autoregulation is implicated.
authors.affiliation: Department of Cardiovascular Sciences, Ageing and Stroke Medicine Group, University of Leicester NHS Trust, Gwendolen Road, Leicester, UK.
authors.forename: Nazia P
authors.initials: NP
authors.lastname: Saeed
authors.forename: Mark A
authors.initials: MA
authors.lastname: Horsfield
authors.forename: Ronney B
authors.initials: RB
authors.lastname: Panerai
authors.forename: Amit K
authors.initials: AK
authors.lastname: Mistri
authors.forename: Tom G
authors.initials: TG
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017585:Ultrasonography, Doppler, Transcranial