title: The relationship between adipocyte fatty acid binding protein-4, retinol binding protein-4 levels and early diabetic nephropathy in patients with type 2 diabetes.
abstract: Adipocyte fatty acid binding protein-4 (A-FABP4) and retinol binding protein-4 (RBP4) have recently been linked to type 2 diabetes mellitus (DM). Serum A-FABP4 and RBP4 levels and their relationships with early diabetic nephropathy were examined in 87 type 2 diabetic patients. The patients with diabetic nephropathy showed high A-FABP4 levels compared to the patients without diabetic nephropathy (p=0.0001). Log A-FABP4 correlated positively with age (p=0.02), log duration of diabetes (p=0.04), log body mass index (BMI) (p=0.0001), log creatinine (p=0.007), log C-reactive protein (CRP) (p=0.01), log albumin excretion rate (AER) (p=0.001), and negatively with MDRD-GFR (p=0.0001). Serum RBP4 levels were similar between the patients with and without diabetic nephropathy. RBP4 correlated positively with triglycerides (p=0.001), log creatinine (p=0.009), and negatively with MDRD-GFR (p=0.04). In regression analysis, log A-FABP4 was associated with age, sex, log BMI, and log AER (r(2)=0.43) and RBP4 was associated with triglycerides and log creatinine (r(2)=0.22). In conclusion, we found high serum A-FABP4 but unchanged RBP4 concentrations and their associations with renal function and early diabetic nephropathy in type 2 DM.
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Besevler, 06500 Ankara, Turkey. fusunbalostoruner@yahoo.com
authors.forename: Fusun
authors.initials: F
authors.lastname: Toruner
authors.forename: Alev E
authors.initials: AE
authors.lastname: Altinova
authors.forename: Mujde
authors.initials: M
authors.lastname: Akturk
authors.forename: Meral
authors.initials: M
authors.lastname: Kaya
authors.forename: Emre
authors.initials: E
authors.lastname: Arslan
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bukan
authors.forename: Erdal
authors.initials: E
authors.lastname: Kan
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yetkin
authors.forename: Metin
authors.initials: M
authors.lastname: Arslan
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000097:blood* / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma