title: [Effects of psychological stress on performances in open-field test of rats and tyrosine's modulation].
abstract: OBJECTIVE
  To explore the effects of different doses of tyrosine modulation on behavioral performances in open field test of psychological stress rats.
  
  
  METHODS
  The animal model of psychological stress was developed by restraint stress for 21 days. Wistar rats were randomly assigned to five groups (n = 10) as follows: control group (CT), stress control group (SCT), low, medium and high-doses of tyrosine modulation stress groups (SLT, SMT and SIT). The changes of behavioral performances were examined by open-field test. Serum levels of cortisol, norepinephrine and dopamine were also detected.
  
  
  RESULTS
  The levels of serum cortisol were all increased obviously in the four stress groups, and their bodyweight gainings were diminished. The behavioral performances of SCT rats in open-field test were changed significantly in contrast to that of CT rats. However, The behavioral performances of SMT and SHT rats were not different from that of CT rats. In addition, the serum levels of norepinephrine and dopamine were downregulated obviously in SCT and SLT groups, and no differences were observed in other groups.
  
  
  CONCLUSIONS
  Psychological stress can impair body behavioral performances, and moderate tyrosine modulation may improve these abnormal changes. The related mechanisms may be involved with the changes of norepinephrine and dopamine.
authors.affiliation: Institute of Health and Environmental Medicine, Tianjin, China.
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Chen
authors.forename: Yi-Yong
authors.initials: YY
authors.lastname: Cheng
authors.forename: Shu-Tian
authors.initials: ST
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Hong
authors.forename: Dong-Lan
authors.initials: DL
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004298:Dopamine / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000523:psychology; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology*; D014443:Tyrosine / Q000627:therapeutic use*
chemical_list: D014443:Tyrosine; D004298:Dopamine; D009638:Norepinephrine