title: [Nanometer detection of self-assembly morphology of sodium hyaluronate injection on mica].
abstract: OBJECTIVE
  To detect the self-assembly morphology of sodium hyaluronate injection on mica using atomic force microscopy(AFM).
  
  
  METHODS
  Atomic force microscopy with nanometer resolution was used to observe the self-assembly morphology of different concentrations of sodium hyaluronate injection on mica at room temperature.
  
  
  RESULTS
  The self-assembly morphology of 0.001, 0.01, and 0.1 mg/ml sodium hyaluronate injection on mica featured piebald, reticular and dendritic structures, respectively. At 1 and 5 mg/ml, sodium hyaluronate injection displayed bacilliform and spherical structures on mica, respectively; the diameter and height of the particles of 5 mg/ml sodium hyaluronate was 197.97±78.48 nm and 30.79±18.67 nm, significantly greater than those of 0.1 mg/ml sodium hyaluronate injection (49.52±11.93 nm and 5.37±1.59 nm, respectively, P<0.05).
  
  
  CONCLUSIONS
  The self-assembly morphology of sodium hyaluronate injection on mica varies with its concentration. The piebald and reticular structure may facilitate the function of sodium hyaluronate, and the dendritic feature resembles the representative model of diffusion-limited aggregation (DLA).
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangzhou, China.
authors.forename: Mu-dan
authors.initials: MD
authors.lastname: He
authors.forename: Tian-xing
authors.initials: TX
authors.lastname: Xu
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Wang
authors.forename: Ya-lan
authors.initials: YL
authors.lastname: Li
authors.forename: Yu-yong
authors.initials: YY
authors.lastname: Liu
authors.forename: Shan-e
authors.initials: SE
authors.lastname: Duan
mesh_terms: D000538:Aluminum Silicates / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D049329:Nanostructures; D013499:Surface Properties
chemical_list: D000538:Aluminum Silicates; D006820:Hyaluronic Acid; C011934:mica