title: Wnt signaling: multivesicular bodies hold GSK3 captive.
abstract: Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.
authors.affiliation: German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, Heidelberg, Germany. niehrs@dkfz.de
authors.forename: Christof
authors.initials: C
authors.lastname: Niehrs
authors.forename: Sergio P
authors.initials: SP
authors.lastname: Acebron