title: Receptor-mediated T cell absorption of antigen presenting cell-derived molecules.
abstract: T cells tend to acquire a variety of cell surface molecules derived from antigen presenting cells (APCs). The molecule uptake occurs mainly during direct T/APC contact and is instigated by specific receptor/ligand interactions, such as T cell receptor (TCR) with a cognate peptide/MHC complex (pMHC) or CD28 with B7. The acquired molecules are targeted for internalization and degradation in the lysosome. Nevertheless, those molecules are expressed on the surface of T cells for a period of time. The presentation of APC-derived ligands by T cells exhibited a multitude of immunological effects via antigen-specific T/T interaction upon recognition of the absorbed antigens by contact with other T cells. Ligand uptake also occurs via absorption of membrane vesicles shed from APCs prior to contact (e.g., exosomes and plasma membrane-derived vesicles). As in ligand absorption via direct T/APC interaction, the absorption of pre-formed membrane vesicles is also dependent on specific receptor/ligand interactions. In this review, biological mechanisms underlying the ligand absorption process as well as the biological significance and application of the event will be discussed.
authors.affiliation: Department of Chemistry and Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. inkyu@scripps.edu
authors.forename: Inkyu
authors.initials: I
authors.lastname: Hwang
authors.forename: DaLim
authors.initials: D
authors.lastname: Ki
mesh_terms: D000042:Absorption; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D055354:Exosomes / Q000502:physiology; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008024:Ligands; D011948:Receptors, Antigen, T-Cell