title: Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review.
abstract: This review examines the current state of the art lab-on-a-chip and microfluidic based biosensor technologies used in the detection of cardiac biomarkers. The determination and quantification of blood based, cardiac biomarkers are crucial in the triage and management of a range of cardiac related conditions, where time delay has a major impact on short and longer-term outcomes of a patient. The design and manufacturing of biomarker detection systems are multi-disciplinary in nature and require researchers to have knowledge of both life sciences and engineering for the full potential of this field to be realised. This review will therefore provide a comprehensive overview of chip based immunosensing technology as applied to cardiac biomarker detection, while discussing the potential suitability and limitations of each configuration for incorporation within a clinical diagnostics device suitable for point-of-care applications.
authors.affiliation: Heriot-Watt University, MicroSystems Engineering Centre (MISEC), School of Engineering & Physical Sciences, Earl Mountbatten Building, Edinburgh, Scotland.
authors.forename: Mazher-Iqbal
authors.initials: MI
authors.lastname: Mohammed
authors.forename: Marc P Y
authors.initials: MP
authors.lastname: Desmulliez
mesh_terms: D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007118:Immunoassay; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques
chemical_list: D015415:Biomarkers