title: [Protective effect of magnesium on hippocampal neurons damage induced by glutamic acid].
abstract: OBJECTIVE
  To investigate the effect of magnesium ion (Mg2+) on neuronic damage induced by 0.1 mmol/L glutamic acid.
  
  
  METHODS
  The neurons isolated from hippocampus in rats were cultured for 6-9 days, and then randomly divided into three groups: A. medium alone. B. medium + glutamic acid. C. medium+ Mg2+, and + glutamic acid (30 min late).
  
  
  RESULTS
  (1) DAs compared with A group, the survival rate of hippocampal neurons in B group was remarkably decreased in dose dependent mauner. (2) In contrast to B group, when the concentration of Mg2+ was lower, the survival rates of hippocampal neurons in C group was significantly increased.
  
  
  CONCLUSIONS
  Mg2+ in lower concentration could protect hippocampal neurons from damage induced by glutamic acid.
authors.affiliation: School of life sciences, Xiangtan Normal University of Hunan, Xiangtan 411201, China.
authors.forename: Feng-ling
authors.initials: FL
authors.lastname: Huang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002470:Cell Survival; D002478:Cells, Cultured; D018698:Glutamic Acid / Q000633:toxicity*; D006624:Hippocampus / Q000166:cytology*; D008274:Magnesium / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018698:Glutamic Acid; D008274:Magnesium