title: [Insulin resistance model induced by dexamethasone in rats].
abstract: OBJECTIVE
  To build a easy and reliable rat model of insulin resistance.
  
  
  METHODS
  Changes concerning sugar metabolism were observed in experimental rats injected intraperitoneally by different doses of dexamethasone.
  
  
  RESULTS
  The changes by dexamethasone in fasting blood insulin and insulin resistance prior to that of fasting blood glucose were dose and time dependent.
  
  
  CONCLUSIONS
  It was convenience to set up a insulin resistance model induced by dexamethasone in rats which would favor other related research.
authors.affiliation: Fujian Uniou Hospital Affiliated to Fujian Medical University, Fujian Institute of Endocrinology, Fujian 350001, China.
authors.forename: Fang-Lin
authors.initials: FL
authors.lastname: Zhang
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Liu
authors.forename: Yi-Chuan
authors.initials: YC
authors.lastname: Linn
authors.forename: Kai-Zhen
authors.initials: KZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D003907:Dexamethasone