title: Glycated albumin is independently associated with estimated glomerular filtration rate in nondiabetic patients with chronic kidney disease.
abstract: BACKGROUND
  Glycated albumin (GA) may contribute to diabetic nephropathy, but the clinical significance of GA in patients with chronic kidney disease (CKD) is unknown.
  
  
  METHODS
  Patients were classified with the NKF/DOQI classification system as mild (stage I, II), moderate (stage III), or advanced CKD (stage IV). Those undergoing dialysis or with CKD stage V were excluded. GA was measured using the Lucica TM GA-L assay kit. The relationship between GA and renal dysfunction was analyzed in patients with or without diabetes.
  
  
  RESULTS
  A total of 187 subjects were enrolled. GA values in those with normal, mild, moderate and advanced CKD were 18.4 ± 1.4%, 18.4 ± 3.1%, 19.0 ± 3.8%, 20.4 ± 6.4%, respectively, in diabetic patients (N=67, p=0.5), and were 14.1 ± 1.9%, 14.2 ± 2.2%, 15.9 ± 1.9%, 15.0 ± 1.7%, respectively, in nondiabetic patients (N=120, p=0.004). GA value was negatively correlated to eGFR in nondiabetic patients (r=-0.35, p<0.001) but not in diabetic patients (r=-0.11, p=0.39). In the adjusted model, GA is independently correlated to eGFR only in nondiabetic subjects.
  
  
  CONCLUSIONS
  Increased GA concentrations are independently associated with renal dysfunction in nondiabetic patients with CKD.
authors.affiliation: Department of Internal Medicine, Cardinal Tien Hospital, Medical School, Catholic Fu Jen University, Xindien City, Taipei County, Taiwan.
authors.forename: Wen-Ya
authors.initials: WY
authors.lastname: Ma
authors.forename: Chia-Chao
authors.initials: CC
authors.lastname: Wu
authors.forename: Dee
authors.initials: D
authors.lastname: Pei
authors.forename: Kuo-Chin
authors.initials: KC
authors.lastname: Hung
authors.forename: Te-Lin
authors.initials: TL
authors.lastname: Hsia
authors.forename: Ching-Chieh
authors.initials: CC
authors.lastname: Su
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Chu
authors.forename: Kuo-Cheng
authors.initials: KC
authors.lastname: Lu
mesh_terms: D005260:Female; D005919:Glomerular Filtration Rate; D006031:Glycosylation; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D012709:Serum Albumin