title: Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones.
abstract: Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albino mice by maximal electroshock method using phenytoin as a standard. The compound (9l) bearing a cinnamyl function displays a very high activity (82.74 %) at dose level of 100 mg/kg b.w.
authors.affiliation: Department of Pharmaceutical Chemistry, C. L. Baid Mehta College of Pharmacy, Jyothi Nagar, Rajiv Gandhi Salai, Thorapakkam, Chennai - 600 097, India.
authors.forename: P
authors.initials: P
authors.lastname: Paneersalvam
authors.forename: T
authors.initials: T
authors.lastname: Raj
authors.forename: M P S
authors.initials: MP
authors.lastname: Ishar
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: B A
authors.initials: BA
authors.lastname: Rather