title: Multiple births conceived by assisted reproductive technology in Korea.
abstract: OBJECTIVE
  The recent trends of multiple births (MBs) conceived by assisted reproductive technology (ART) in Korea were analyzed as well as the relationship with maternal age, especially advanced maternal age.
  
  
  METHODS
  Data were obtained from the Korean Statistical Information Service and annual ART reports from the ART committee of the Korean Society of Obstetrics and Gynecology.
  
  
  RESULTS
  MBs increased from the early 1990s; there was a 275% increase by 2008. The number of total live births was 448,153 and MBs accounted for 10,767; the MB rate was 24.0% in 2006. Among 2,326 deliveries conceived by ART, multiple deliveries accounted for 786 (33.8%). The total number of live births with ART was 3,125 and 1,585 (50.7%) of them were MBs. During 2006, 14.7% of the entire MBs in Korea were associated with ART. The proportion of women of advanced maternal age was much higher in the ART group than in the total live birth group.
  
  
  CONCLUSIONS
  MBs in women of advanced maternal age have been increasing in Korea with the use of ART. The results of this study showed that ART was a significant factor associated with the increase in MBs in Korea.
authors.affiliation: Department of Pediatrics, Kyung Hee University East West Neo Medical Center, Seoul, Korea.
authors.forename: Young Sil
authors.initials: YS
authors.lastname: Park
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Kye Shik
authors.initials: KS
authors.lastname: Shim
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Chang
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Hahn
authors.forename: Yong Sung
authors.initials: YS
authors.lastname: Choi
authors.forename: Chong-Woo
authors.initials: CW
authors.lastname: Bae