title: Copper-catalyzed intramolecular C-N bond formation: a straightforward synthesis of benzimidazole derivatives in water.
abstract: A straightforward, efficient, and more sustainable copper-catalyzed method has been developed for intramolecular N-arylation providing the benzimidazole ring system. With Cu(2)O (5 mol %) as the catalyst, DMEDA (10 mol %) as the ligand, and K(2)CO(3) as the base, this protocol was applied to synthesize a small library of benzimidazoles in high yields. Remarkably, the reaction was exclusively carried out in water, rendering the methodology highly valuable from both environmental and economical points of view.
authors.affiliation: Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin, 150040, PR China. jspeng1998@163.com
authors.forename: Jinsong
authors.initials: J
authors.lastname: Peng
authors.forename: Min
authors.initials: M
authors.lastname: Ye
authors.forename: Cuijuan
authors.initials: C
authors.lastname: Zong
authors.forename: Fangyun
authors.initials: F
authors.lastname: Hu
authors.forename: Lingtong
authors.initials: L
authors.lastname: Feng
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Chunxia
authors.initials: C
authors.lastname: Chen
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014867:Water / Q000737:chemistry*
chemical_list: D001562:Benzimidazoles; D014867:Water; D003300:Copper