title: Interplay between p53-family, their regulators, and PARPs in DNA repair.
abstract: Abnormalities of the p53 tumor suppressor gene are among the most frequent molecular events in human neoplasia. p53 is consequently one of the most studied proteins, and is the subject of over 55,500 scientific papers. In this review, attention is focused on the functions of p53 in DNA repair. We highlight the recent progress in the analysis of protein signals to p53, including PARPs, and ubiquitination cascade proteins MDM2, CRM1, USP10 and 14-3-3σ.
authors.affiliation: Inserm UMR S938, centre de recherche Saint-Antoine, université Pierre-et-Marie-Curie (université Paris-6), 184, rue du faubourg-Saint-Antoine, 75571 Paris cedex 12, France. shahin.emami@inserm.fr
authors.forename: S
authors.initials: S
authors.lastname: Emami
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism*; D004260:DNA Repair; D016158:Genes, p53; D006801:Humans; D028884:Karyopherins / Q000378:metabolism*; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*; D000097606:Exportin 1 Protein
chemical_list: D048948:14-3-3 Proteins; D028884:Karyopherins; D009687:Nuclear Proteins; D011065:Poly(ADP-ribose) Polymerases; D051736:Proto-Oncogene Proteins c-mdm2; D018160:Receptors, Cytoplasmic and Nuclear; D016159:Tumor Suppressor Protein p53; D043222:Ubiquitin Thiolesterase; D000097606:Exportin 1 Protein; C431363:USP10 protein, human