title: Characterization of extended-spectrum beta-lactamases and qnr plasmid-mediated quinolone resistance in German isolates of Enterobacter species.
abstract: The objective of this study was to characterize the antimicrobial resistance patterns of 100 clinical isolates of Enterobacter spp. with special regard to the occurrence of extended-spectrum beta-lactamases (ESBLs) and plasmid-mediated quinolone resistance by qnr-determinants. The rate of ESBL- and qnr-positive isolates was 7% and 14%, respectively. Thirteen isolates harbored a qnrA1, and a further isolate harbored a qnrB4 gene. Moreover, qnr-determinants were significantly associated with ESBL-expression. No carbapeneme or tigecycline resistance was detected in the collective tested. To conclude, these data confirm the increase of multiple antimicrobial resistance mechanisms in Enterobacter spp.
authors.affiliation: Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
authors.forename: Sophia
authors.initials: S
authors.lastname: Müller
authors.forename: Anett
authors.initials: A
authors.lastname: Oesterlein
authors.forename: Matthias
authors.initials: M
authors.lastname: Frosch
authors.forename: Marianne
authors.initials: M
authors.lastname: Abele-Horn
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Valenza
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004754:Enterobacter / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D015363:Quinolones / Q000494:pharmacology*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015363:Quinolones; D001618:beta-Lactamases