title: Racial differences in hypogonadal improvement and prostate-specific antigen levels in hypogonadal men treated with testosterone replacement therapy.
abstract: OBJECTIVE
  To observe hypogonadal men undergoing testosterone replacement therapy (TRT) and assess racial differences in hypogonadal improvement and prostate-specific antigen (PSA) levels.
  
  
  METHODS
  In a retrospective analysis, 75 hypogonadal men were followed for an average 34 months after initiating TRT. Total testosterone and PSA levels were assessed every 6 months, and patients diagnosed with prostatitis or prostate cancer during treatment were excluded.
  
  
  RESULTS
  For 16 African American men, the average age at diagnosis of hypogonadism was 53.5 years, compared with 57.8 years in 59 Caucasian men (p=NS). Pre- and post-treatment testosterone was 219 ng/dL and 310 ng/dL in African American men, and 247 ng/dL and 497 ng/dL in Caucasian men (p=NS). Symptomatic response was 81% in African American men and 93% in Caucasian men (p=NS). Baseline PSA level was 1.32 ng/mL in African American men and 1.27 ng/mL in Caucasian men, and there was no significant difference in PSA between racial groups at 6-month intervals, although there was a small decreasing trend in the PSA of African Americans compared with Caucasians.
  
  
  CONCLUSIONS
  Hypogonadal African American men have a similar normalization of testosterone and symptomatic response as hypogonadal Caucasian men, and PSA levels remain stable over time in both groups. In this hypogonadal cohort, in contrast to studies of eugonadal men, higher PSA levels in African Americans were not observed.
authors.affiliation: Division of Urologic Surgery, The University of North Carolina, Chapel Hill, North Carolina 27599-7235, USA. rcoward@unch.unc.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Coward
authors.forename: Jay
authors.initials: J
authors.lastname: Simhan
authors.forename: Culley C
authors.initials: CC
authors.lastname: Carson
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000208:ethnology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis*; D012189:Retrospective Studies; D013739:Testosterone / Q000172:deficiency* / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D044465:White People; D055815:Young Adult
chemical_list: D013739:Testosterone; D017430:Prostate-Specific Antigen