title: Estrogen receptor beta genetic variants and combined oral contraceptive use as relates to the risk of hypertension in Chinese women.
abstract: OBJECTIVE
  Estrogen receptor beta (ESR2) plays an important role in cardiovascular physiology and blood pressure regulation, whereas estrogens may influence gene expression, growth, and cellular differentiation in target tissues by activating estrogen receptors. This study aims to investigate the association between common genetic variants of ESR2 gene and the risk of hypertension and to explore the combined effected of ESR2 variants and combined oral contraceptive (COC) use for hypertension risk.
  
  
  METHODS
  A population-based case-control study was conducted in 621 female hypertensive patients and 621 female normotensive controls.
  
  
  RESULTS
  ESR2 G1082A heterozygote genotype (GA) was in significant relationship with hypertension (crude odds ratio [OR] = 1.38, 95% CI: 1.09-1.76; adjusted odds ratio [OR] = 1.38, 95% CI: 1.09-1.76). No association was observed for ESR2 G1730A polymorphism. Furthermore, the joint effects of the heterozygote of G1082A polymorphism (heterozygote model: GG/AA vs. GA) and cumulative COC use time ≥15 years significantly increased the risk of hypertension [adjusted odds ratio (OR) = 2.19, 95% CI: 1.49-3.24], and the interaction effects between those two risk factors were significant (p = 0.0001).
  
  
  CONCLUSIONS
  The heterozygote GA genotype of ESR2 gene G1082A polymorphism may be a risk genotype for hypertension in Chinese women, and the GA genotype (heterozygote model: GG/AA vs. GA) of G1082A locus together with COC use simultaneously contributed to hypertension development.
authors.affiliation: Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Hongxin
authors.initials: H
authors.lastname: Pan
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Sun
authors.forename: Yulin
authors.initials: Y
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Ba
authors.forename: Jinna
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D003277:Contraceptives, Oral, Combined; D047629:Estrogen Receptor beta