title: Migraine and preterm birth.
abstract: OBJECTIVE
  To investigate whether maternal migraine was associated with preterm birth.
  
  
  METHODS
  Case-control sample within a population-based study of risk factors for cerebral palsy (CP). Infants without CP were matched for gestational age with those with CP. Maternal migraine was self-identified at first prenatal visit, most in the first trimester.
  
  
  RESULTS
  Infants without CP born to women with migraine had a higher rate of preterm birth (odds ratio (OR)=3.5, 95% confidence interval (CI) 1.5, 8.5), as did infants who died in the perinatal period (OR=7.3, 95% CI 0.98, 54), the difference marginal for nominal statistical significance. In all outcome groups, infants of women with migraine had a higher observed rate of suboptimal intrauterine growth. In term infants, the rate of maternal migraine was higher in those with CP than in controls (OR=2.18, 95% CI 0.92, 5.25). Pre-eclampsia was reported more frequently in women with migraine who gave birth to a child with CP or a perinatal death, particularly in those born preterm; OR=5.1 (1.3, 20) and OR=2.9 (1.1, 7.6), respectively, but not in women giving birth to a control whether term or preterm.
  
  
  CONCLUSIONS
  Maternal migraine, as self-reported early in pregnancy, was associated with preterm birth in survivors without CP and in infants who died in the perinatal period. The combination of maternal migraine and pre-eclampsia was associated with CP and perinatal death. The association of maternal migraine with outcomes of pregnancy warrants further study.
authors.affiliation: Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, West Path.
authors.forename: E M
authors.initials: EM
authors.lastname: Blair
authors.forename: K B
authors.initials: KB
authors.lastname: Nelson
mesh_terms: D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000453:epidemiology / Q000401:mortality; D003430:Cross-Sectional Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000401:mortality; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008881:Migraine Disorders / Q000453:epidemiology*; D007752:Obstetric Labor, Premature / Q000453:epidemiology*; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D012307:Risk Factors; D015996:Survival Rate; D014904:Western Australia