title: Effects of local electric fields on the redox free energy of single stranded DNA.
abstract: Influence of external electric field as well as base substitution effects on the reduction/oxidation free energies of single stranded DNA suggest that base sequencing via measuring redox properties might be feasible under the conditions that (i) a difference of ∼ 230 kJ mol(-1) in the oxidation potentials is enough to discriminate between nucleobases conductance signals and (ii) the strand is long enough to reduce end effects.
authors.affiliation: Departamento de Bioquímica y Biología Molecular Universitat de Barcelona, Barcelona, Spain. marco.dabramo.cnio@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: D'Abramo
authors.forename: Modesto
authors.initials: M
authors.lastname: Orozco
authors.forename: Andrea
authors.initials: A
authors.lastname: Amadei
mesh_terms: D004277:DNA, Single-Stranded / Q000737:chemistry*; D055664:Electrochemical Techniques; D008962:Models, Theoretical; D010084:Oxidation-Reduction; D011789:Quantum Theory; D013816:Thermodynamics
chemical_list: D004277:DNA, Single-Stranded