title: Synthesis of molluscicidal agent cyanolide a macrolactone from D-(-)-pantolactone.
abstract: An efficient synthesis of potent molluscicidal agent cyanolide A, a glycosidic 16-membered macrolide, starting from D-(-)-pantolactone is reported. Highly stereoselective aldol, oxa-Michael addition, and Yamaguchi macrolactonization are the key steps in the present synthesis.
authors.affiliation: Advinus Therapeutics Ltd., Pune, India.
authors.forename: Atul K
authors.initials: AK
authors.lastname: Hajare
authors.forename: Velayutham
authors.initials: V
authors.lastname: Ravikumar
authors.forename: Shaik
authors.initials: S
authors.lastname: Khaleel
authors.forename: Debnath
authors.initials: D
authors.lastname: Bhuniya
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008975:Molluscacides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; D008975:Molluscacides; C548188:cyanolide A; C005412:pantolactone; D015107:4-Butyrolactone