title: Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin.
abstract: Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with β-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with β-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with β-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results.
authors.affiliation: Gurunanak College of Pharmacy, Near Dixit Nagar, Nari, Nagpur-440 026, India.
authors.forename: Nidhi P
authors.initials: NP
authors.lastname: Sapkal
authors.forename: Vaishali A
authors.initials: VA
authors.lastname: Kilor
authors.forename: Bharti D
authors.initials: BD
authors.lastname: Shewale
authors.forename: K P
authors.initials: KP
authors.lastname: Bhusari
authors.forename: A S
authors.initials: AS
authors.lastname: Daud