title: Growth hormone-releasing hormone stimulates the secretion of interleukin 17 from human peripheral blood mononuclear cells in vitro.
abstract: OBJECTIVE
  Growth hormone-releasing hormone (GHRH) plays a crucial role in the secretion of GH from the pituitary, acts as a growth factor in variety of cancer cells and possesses immunomodulatory activity. Interleukin(IL)-17 apart from its pro-inflammatory role has been also shown to play a role in carcinogenesis. The effect of GHRH on the IL-17 has not been studied so far.
  
  
  OBJECTIVE
  To evaluate the effect of GHRH on the secretion of IL-17 from human peripheral blood mononuclear cells (PBMC) in vitro.
  
  
  METHODS
  The concentrations of IL-17 in supernatants from PBMC cultured for 24 hrs were assessed using ELISA kit.
  
  
  RESULTS
  We show for the first time that GHRH can stimulate the secretion of IL-17 from human PBMC in 24 hrs culture, and that GHRH antagonist counteracts this effect.
  
  
  CONCLUSIONS
  Our study further elucidates the immunomodulatory role of GHRH.
authors.affiliation: Department of General and Endocrinological Surgery, Copernicus Memorial Hospital, Pabianicka Street 62, 93-513 Lodz, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stepien
authors.forename: Hanna
authors.initials: H
authors.lastname: Lawnicka
authors.forename: Jan
authors.initials: J
authors.lastname: Komorowski
authors.forename: Henryk
authors.initials: H
authors.lastname: Stepien
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Siejka
mesh_terms: D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D020381:Interleukin-17 / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*
chemical_list: D020381:Interleukin-17; D013007:Growth Hormone-Releasing Hormone