title: Blood donations from previously transfused or pregnant donors: a multicenter study to determine the frequency of alloexposure.
abstract: BACKGROUND
  Transfusion-related acute lung injury (TRALI) mitigation strategies include the deferral of female donors from apheresis platelet (PLT) donations and the distribution of plasma for transfusion from male donors only. We studied the implications of these policies in terms of component loss at six blood centers in the United States.
  
  
  METHODS
  We collected data from allogeneic blood donors making whole blood and blood component donations during calendar years 2006 through 2008. We analyzed the distribution of donations in terms of the sex, transfusion and pregnancy histories, and blood type.
  
  
  RESULTS
  A TRALI mitigation policy that would not allow plasma from female whole blood donors to be prepared into transfusable plasma components would result in nearly a 50% reduction in the units of whole blood available for plasma manufacturing and would decrease the number of type AB plasma units that could be made from whole blood donations by the same amount. Deferral of all female apheresis PLT donors, all female apheresis PLT donors with histories of prior pregnancies, or all female apheresis PLT donors with histories of prior pregnancies and positive screening test results for antibodies to human leukocyte antigens (HLAs) will result in a loss of 37.1, 22.5, and 5.4% of all apheresis PLT donations, respectively.
  
  
  CONCLUSIONS
  A TRALI mitigation policy that only defers female apheresis PLT donors with previous pregnancies and HLAs would result in an approximately 5% decrease in the inventory of apheresis PLTs, but would eliminate a large proportion of components that are associated with TRALI.
authors.affiliation: New England Region, American Red Cross Blood Services, Dedham, Massachusetts, USA.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Rios
authors.forename: Karen S
authors.initials: KS
authors.lastname: Schlumpf
authors.forename: Ram M
authors.initials: RM
authors.lastname: Kakaiya
authors.forename: Darrell J
authors.initials: DJ
authors.lastname: Triulzi
authors.forename: John D
authors.initials: JD
authors.lastname: Roback
authors.forename: Steve H
authors.initials: SH
authors.lastname: Kleinman
authors.forename: Edward L
authors.initials: EL
authors.lastname: Murphy
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Gottschall
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Carey
mesh_terms: D001782:Blood Donors / Q000706:statistics & numerical data*; D001803:Blood Transfusion / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D010983:Plateletpheresis / Q000706:statistics & numerical data; D011247:Pregnancy