title: [Heat shock response in guinea pigs cochlea with gentamicin ototoxicity].
abstract: OBJECTIVE
  To explore the effects of gentamicin ototoxicity on the expression of heat shock protein 70 in guinea pigs cochlea.
  
  
  METHODS
  We used immunohistochemistry staining and image quantitative analysis system, combined with auditory brainstem response (ABR) measurement to investigate the change on the expression of HSP70 in guinea pigs cochlea of gentamicin ototoxicity.
  
  
  RESULTS
  The levels of HSP70 immunoreactivity in guinea pigs cochlea of experimental animals were high including Corti's organ, stria vascularis, medial spiral limbus, spiral ganglion cells and the threshold of ABR was in high correlation with the expression of HSP70 ([ r] > 0.8, P < 0.01).
  
  
  CONCLUSIONS
  Gentamicin can induce expression of HSP 70 in guinea pigs cochlea and protect hearing function.
authors.affiliation: Hearing Research Laboratory, China Medical University, Shenyang 110001, China.
authors.forename: Yue-Qiu
authors.initials: YQ
authors.lastname: Ni
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.forename: Wen-Shuang
authors.initials: WS
authors.lastname: Fu
mesh_terms: D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology; D005839:Gentamicins / Q000633:toxicity*; D006168:Guinea Pigs; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response / Q000187:drug effects*
chemical_list: D005839:Gentamicins; D018840:HSP70 Heat-Shock Proteins