title: Assessment of cerebral perfusion from bypass arteries using magnetic resonance regional perfusion imaging in patients with moyamoya disease.
abstract: OBJECTIVE
  The purpose of this study was to evaluate whether cerebral perfusion from bypassed arteries can be demonstrated on regional perfusion imaging (RPI) using arterial spin labeling. We then compared cerebral perfusion on RPI and digital subtraction angiography (DSA) in moyamoya patients who underwent extracranial-intracranial bypass surgery.
  
  
  METHODS
  We performed RPI using a 3-T magnetic resonance scanner and DSA studies in 11 moyamoya patients treated by bypass surgery. For RPI we placed a selective labeling slab on the bypassed external carotid artery. Two neuroradiologists determined the extent and location of the cerebral perfusion from bypass arteries in the middle cerebral artery territories on RPI and DSA. Kappa analysis was used to assess the interobserver agreement with respect to the extent and location of the cerebral perfusion and to evaluate the intermodality agreement between RPI and DSA.
  
  
  RESULTS
  Interobserver agreement for the extent of cerebral perfusion on RPI was very good (kappa=0.89), with excellent location (kappa=1.00). Intermodality agreement for the extent of perfusion was very good (kappa=0.89), with good location (kappa=0.74).
  
  
  CONCLUSIONS
  RPI is useful for evaluating cerebral perfusion from bypass arteries in moyamoya patients.
authors.affiliation: Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan. mkitaji@kumamoto-u.ac.jp
authors.forename: Mika
authors.initials: M
authors.lastname: Kitajima
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hirai
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Fukuoka
authors.forename: Akira
authors.initials: A
authors.lastname: Sasao
authors.forename: Tomoko
authors.initials: T
authors.lastname: Okuda
authors.forename: Motohiro
authors.initials: M
authors.lastname: Morioka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kai
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000293:Adolescent; D000328:Adult; D015901:Angiography, Digital Subtraction / Q000379:methods; D002548:Cerebral Revascularization; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology*; D009072:Moyamoya Disease / Q000473:pathology*; D015588:Observer Variation; D011183:Postoperative Complications / Q000473:pathology; D012189:Retrospective Studies; D013113:Spin Labels; D013699:Temporal Arteries / Q000473:pathology*; D055815:Young Adult
chemical_list: D013113:Spin Labels