title: [The role of dorsomedial hypothalamic nucleus in the cardiovascular responses induced by habenular nucleus stimulation and inhibitory effect of deep peroneal nerve].
abstract: OBJECTIVE
  To explore whether dorsomedial hypothalamic nucleus (DMH) is involved in the cardiovascular responses induced by habenular nucleus (Hb) stimulation and inhibitory effect of deep peroneal nerve (DPN) stimulation on above responses or not and to analysis transmitter mechanism.
  
  
  METHODS
  Experiments were performed on white male rabbits anesthetised with chloralose and urethan. Experimental data were collected by means of stimulating Hb and DPN, recording arterial blood pressure and ectal electrocardiogram (EECG) and microinjecting transmitter blocker.
  
  
  RESULTS
  Prominent pressor and ischemic EECG segment changes were elicited by Hb stimulation (P < 0.01) Microinjecting kynurenic acid into ipsilateral DMH had partial blocking effect on pressor and ischemic EECG-ST segment changes induced by Hb stimulation (P < 0.01). Stimulation of bilateral DPN prominently inhibited the pressor and ischemic EECG-ST changes induced by Hb stimulation (P < 0.01, P < 0.05). Microinjecting naloxone into ipsilateral DMH decreased the inhibitory effect of DPN stimulation on above cardiovascular responses elicited by Hb stimulation (P < 0.01, P < 0.05).
  
  
  CONCLUSIONS
  Glutamic acid receptor in DMH is involved in pressor and ischemic changes induced by Hb stimulation. DMH and opiate peptide receptors in DMH are involved in the inhibitory effect of DPN stimulation on pressor and ischemic changes induced by Hb stimulation.
authors.affiliation: Department of Physiology, College of Medical Sciences, Zhejiang University, Hangzhou 310006, China.
authors.forename: Ling-Ju
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Rong-Bao
authors.initials: RB
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002319:Cardiovascular System; D004302:Dorsomedial Hypothalamic Nucleus / Q000502:physiology*; D004558:Electric Stimulation; D004562:Electrocardiography; D019262:Habenula / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D010543:Peroneal Nerve / Q000502:physiology*; D011817:Rabbits