title: Data warehousing methods and processing infrastructure for brain recovery research.
abstract: In order to accelerate translational neuroscience with the goal of improving clinical care it has become important to support rapid accumulation and analysis of large, heterogeneous neuroimaging samples and their metadata from both normal control and patient groups. We propose a multi-centre, multinational approach to accelerate the data mining of large samples and facilitate data-led clinical translation of neuroimaging results in stroke. Such data-driven approaches are likely to have an early impact on clinically relevant brain recovery while we simultaneously pursue the much more challenging model-based approaches that depend on a deep understanding of the complex neural circuitry and physiological processes that support brain function and recovery. We present a brief overview of three (potentially converging) approaches to neuroimaging data warehousing and processing that aim to support these diverse methods for facilitating prediction of cognitive and behavioral recovery after stroke, or other types of brain injury or disease.
authors.affiliation: Rotman Research Institute and Centre for Stroke Recovery, Baycrest, Toronto, Canada. tgee@rotman-baycrest.on.ca
authors.forename: T
authors.initials: T
authors.lastname: Gee
authors.forename: S
authors.initials: S
authors.lastname: Kenny
authors.forename: C J
authors.initials: CJ
authors.lastname: Price
authors.forename: M L
authors.initials: ML
authors.lastname: Seghier
authors.forename: S L
authors.initials: SL
authors.lastname: Small
authors.forename: A P
authors.initials: AP
authors.lastname: Leff
authors.forename: A
authors.initials: A
authors.lastname: Pacurar
authors.forename: S C
authors.initials: SC
authors.lastname: Strother
mesh_terms: D001930:Brain Injuries / Q000503:physiopathology*; D019295:Computational Biology; D003628:Database Management Systems / Q000706:statistics & numerical data*; D006801:Humans; D008954:Models, Biological; D020127:Recovery of Function / Q000502:physiology*; D013997:Time Factors