title: Efficacy of a bioactive alloplast, in the treatment of human periodontal osseous defects-a clinical study.
abstract: Presently, bone replacement grafts are one of the modalities of therapy for which there is histologic evidence of regeneration coronal to the base of the previous osseous defect. Bioactive glasses are used extensively in medicine and dentistry. This study evaluated the additional efficacy of a bioactive alloplast, Perioglas, in comparison with open flap debridement only. 8 systemically healthy volunteers were chosen, each having 2 collateral sites with ≥6 mm clinical probing depth and radiographic evidence of an intrabony defect. Randomly, one defect was treated with open flap debridement plus bioactive glass (test) and the other with open flap debridement alone (control). At baseline, 3, 6, 9 months measurements were recorded which included plaque index, gingival index, pocket probing depth, clinical attachment level, and increase in gingival recession. Standardized radiographs were used to measure defect fill and alveolar crest resorption. The data were subjected to statistical analysis. Both treatments showed no significant differences between the two groups at any point of time. However, radiographically, bioactive glass group showing significant improvement in bone fill over the sites treated with open flap debridement alone. The alloplastic bone graft material, PerioGlas, demonstrated clinical advantages beyond that achieved by debridement alone.
authors.affiliation: Rajarajeswari Dental College and Hospital, Bangalore, Karnataka, India. subbaiah_rajiv@rediffmail.com
authors.forename: Rajiv
authors.initials: R
authors.lastname: Subbaiah
authors.forename: Biju
authors.initials: B
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002516:Ceramics; D006801:Humans; D008875:Middle Aged; D057747:Periodontal Debridement; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D018786:Bone Substitutes