title: Isolation and characterization of a process impurity in tizanidine hydrochloride.
abstract: A new process impurity was detected during the HPLC analysis of Tizanidine hydrochloride (I) batches. The impurity (II) was isolated by preparative HPLC and characterized by NMR and Mass spectral analysis as 5-S-ethyl-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride.
authors.affiliation: Mylan India Pvt. Ltd., Plot 1A/2, M.I.D.C. Industrial Estate, Taloja - 410 208, India.
authors.forename: E K S
authors.initials: EK
authors.lastname: Vijayakumar
authors.forename: V G
authors.initials: VG
authors.lastname: Gore
authors.forename: A
authors.initials: A
authors.lastname: Mahajan
authors.forename: M
authors.initials: M
authors.lastname: Kumar