title: Pharmacokinetics and dosage regimen of ciprofloxacin following single intramuscular administration in Teddy goats.
abstract: The objective of this study was to determine the pharmacokinetics and dosage regimen of ciprofloxacin in Teddy goats. Ciprofloxacin was administered intramuscularly at 5 mg/kg body weight in each of eight animals. Following drug administration, blood samples were collected at different time intervals and analyzed for ciprofloxacin using HPLC. Pharmacokinetic parameters were calculated using two compartment open model. Peak plasma concentration (Cmax) of ciprofloxacin, 1.77±0.20 µg/ml was achieved at 0.90±0.04 hours (Tmax). Values for half-life of absorption (t1/2 abs), distribution (t1/2 α) and elimination (t1/2 β) were 0.52±0.04, 0.52±0.04 and 2.62±0.39 hours, respectively. The value for apparent volume of distribution (Vd) was 3.76±0.92 l/kg, area-under-the-curve (AUC) 5.89±0.91 µg.hr/ml and total body clearance (CL) was 1.09±0.11 l/hr/kg. Based on these results, it was concluded that calculated dose should be higher than the dose recommended by the manufacturer to treat susceptible bacteria in goats.
authors.affiliation: Department of Pharmacology, Isra University, Hyderabad, Pakistan. zahid_dr@ymail.com
authors.forename: Zahid
authors.initials: Z
authors.lastname: Iqbal
authors.forename: Ijaz
authors.initials: I
authors.lastname: Javed
authors.forename: Abdul
authors.initials: A
authors.lastname: Basit
authors.forename: Ibadullah
authors.initials: I
authors.lastname: Jan
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Khan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006041:Goats / Q000378:metabolism*; D006207:Half-Life; D007273:Injections, Intramuscular; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin