title: Effects of two different dosing regimens of terlipressin on organ functions in ovine endotoxemia.
abstract: OBJECTIVE
  To test the hypothesis that a continuous infusion of the vasopressin analog terlipressin is associated with less organ dysfunction as compared to intermittent bolus infusion in an ovine sepsis model.
  
  
  METHODS
  Twenty-seven adult female sheep.
  
  
  METHODS
  All sheep were subjected to a Salmonella typhosa endotoxin infusion (10 ng/kg/min). After 16 h of endotoxemia, the surviving animals (n = 24) were randomized to (1) an untreated control group, (2) a continuous terlipressin group (2 mg/24 h), or (3) a terlipressin bolus group (1 mg/6 h).
  
  
  METHODS
  Hemodynamic variables were measured and blood was withdrawn at specific time points for the assessment of organ functions.
  
  
  RESULTS
  Continuous terlipressin infusion was associated with improved surrogate parameters of myocardial, renal, and hepatic function as compared with terlipressin bolus infusion. Reduced vascular hyperpermeability was evidenced by an attenuated decrease in plasma protein concentrations in sheep treated with continuous terlipressin infusion as compared to bolus injection or no treatment.
  
  
  CONCLUSIONS
  Continuous infusion of low-dose terlipressin preserved several surrogate parameters of organ function better than intermittent bolus injections in sheep with systemic inflammation.
authors.affiliation: Department of Anesthesiology and Intensive Care, University of Muenster, Albert-Schweitzer Str. 33, 48149, Muenster, Germany. lanm@gmx.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Lange
authors.forename: Christian
authors.initials: C
authors.lastname: Ertmer
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rehberg
authors.forename: Andrea
authors.initials: A
authors.lastname: Morelli
authors.forename: Gabriele
authors.initials: G
authors.lastname: Köhler
authors.forename: Tim G
authors.initials: TG
authors.lastname: Kampmeier
authors.forename: Hugo
authors.initials: H
authors.lastname: Van Aken
authors.forename: Martin
authors.initials: M
authors.lastname: Westphal
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000188:drug therapy*; D004731:Endotoxins / Q000378:metabolism; D005260:Female; D006439:Hemodynamics; D007249:Inflammation; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010539:Permeability; D011897:Random Allocation; D012485:Salmonella typhi / Q000378:metabolism; D012756:Sheep; D000077585:Terlipressin; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D001798:Blood Proteins; D004731:Endotoxins; D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin