title: Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome.
abstract: To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months. The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone-binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics.
authors.affiliation: Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, Siena, Italy. morgante@unisi.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Morgante
authors.forename: Claudia
authors.initials: C
authors.lastname: Tosti
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
authors.forename: Maria C
authors.initials: MC
authors.lastname: Musacchio
authors.forename: Paola
authors.initials: P
authors.lastname: Piomboni
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Leo
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood; D053627:Asthenozoospermia / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007248:Infertility, Male / Q000097:blood / Q000150:complications / Q000188:drug therapy; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008687:Metformin / Q000494:pharmacology*; D009845:Oligospermia / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D012661:Semen / Q000187:drug effects* / Q000502:physiology; D055101:Semen Analysis; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
chemical_list: D000728:Androgens; D007004:Hypoglycemic Agents; D012738:Sex Hormone-Binding Globulin; D008687:Metformin