title: Reassortment between seasonal and swine-origin H1N1 influenza viruses generates viruses with enhanced growth capability in cell culture.
abstract: One year after the emergence of the 2009 influenza (H1N1) pandemic, most cases have been relatively mild; however, the possibility of enhanced viral growth ability by reassortment with seasonal viruses cannot be overlooked. Here, we show that reassortant viruses containing a seasonal H1 HA and swine-origin NA and M genes have enhanced virus growth over their wild-type parental viruses. The emergence of such viruses in nature could, therefore, represent a threat.
authors.affiliation: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Cássio Pontes
authors.initials: CP
authors.lastname: Octaviani
authors.forename: Chengjun
authors.initials: C
authors.lastname: Li
authors.forename: Takeshi
authors.initials: T
authors.lastname: Noda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kawaoka
mesh_terms: D000818:Animals; D002460:Cell Line; D002645:Chickens; D004912:Erythrocytes / Q000821:virology; D005814:Genes, Viral / Q000235:genetics; D006168:Guinea Pigs; D057809:HEK293 Cells; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000502:physiology*; D007251:Influenza, Human / Q000821:virology*; D009976:Orthomyxoviridae Infections / Q000821:virology; D016865:Reassortant Viruses / Q000235:genetics / Q000502:physiology*; D011991:Receptors, Virus / Q000378:metabolism; D014422:Turkeys
chemical_list: D011991:Receptors, Virus