title: [Relationship between transforming growth factor beta-1 gene-509C/T polymorphism and severe chronic periodontitis].
abstract: OBJECTIVE
  To investigate the relationship between transforming growth factor beta-1 (TGF-β(1)) gene-509C/T polymorphism and severe chronic periodontitis in Chinese Hans population.
  
  
  METHODS
  TGF-β(1)-509C/T genotype polymorphism was analyzed in 102 patients with severe chronic periodontitis (periodontitis group) and 102 healthy controls (control group) by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  The distributions of TGF-β(1)-509C/T genotype and allele were significantly different between severe chronic periodontitis group and control group (P < 0.05). TGF-β(1)-509CC, CT and TT genotype frequency were 44.1% (45/102), 47.1% (48/102), 8.8% (9/102) in periodontitis group and 29.4% (30/102), 51.0% (52/102), 19.6% (20/102) in control group, respectively. The relative risk analysis found that C allele carriers had higher risk of suffering from severe chronic periodontitis compared with T allele carriers (OR = 1.718, 95%CI: 1.148-2.569).
  
  
  CONCLUSIONS
  TGF-β(1)-509C/T polymorphism is associated with severe chronic periodontitis in Chinese Hans population, and C allele may be an important genetic susceptibility gene for severe chronic periodontitis.
authors.affiliation: Department of Stomatology, Henan Provincial People's Hospital, Zhengzhou 450003, China.
authors.forename: Xi-zhen
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Ze-min
authors.initials: ZM
authors.lastname: Guan
authors.forename: Yan-min
authors.initials: YM
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D055113:Chronic Periodontitis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1