title: [Expression of integrin-linked kinase in oral squamous cell cancinoma and its significance].
abstract: OBJECTIVE
  To investigate the expression patterns of integrin-linked kinase (ILK) in oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  The expression of ILK in 170 OSCC cases was examined by immunohistochemistry and periodic acid-schiff histochemistry.
  
  
  RESULTS
  ILK immunoreactivity occurred in cancer cells and(or) stroma encircling the malignant tissue. Along with the deteriorated histopathologic grade of oral cancer, there was stepwise aberration exhibiting from ILK-negative, to ILK-positive in epithelia, to ILK-positive in both epithelia and stroma, and to ILK-positive in stroma. Through non-parameter test, in both lymphatic invasion [ILK-positive in stroma in well-differentiated, moderately-differentiated and poorly-differentiated is 2% (1/50), 18% (6/33) and 64% (18/28), respectively] and non-lymphatic invasion group [ILK-positive in stroma in well-differentiated, moderately-differentiated and poorly-differentiated is 16% (4/25), 9/18 and 10/16, respectively), the expression patterns of ILK exhibited significant correlations with histopathology (F = 17.742, P < 0.001, F = 4.394, P = 0.017). ILK expression between lymphatic metastasis and non-lymphatic metastasis group was significantly different (χ(2) = 14.418, P = 0.002).
  
  
  CONCLUSIONS
  ILK inclines to express in stroma during the OSCC progress.
authors.affiliation: Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Zhu-ling
authors.initials: ZL
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002454:Cell Differentiation; D004847:Epithelial Cells; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000099200:Scaffold Protein ILK
chemical_list: D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK