title: Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography.
abstract: Polarization-sensitive optical coherence tomography (PS-OCT) is known to be advantageous because of its additional tissue-specific contrast of the anterior eye. So far, this advantage has been shown only qualitatively. We evaluate the improved visibility afforded by 3-D PS corneal and anterior eye segment OCT (PS-CAS-OCT) in visualizing the trabecular meshwork (TM) based on statistical evidences. A total of 31 normal subjects participated in this study. The anterior eye segments of both the eyes of the subjects are scanned using a custom-made PS-CAS-OCT and the standard-scattering OCT (S-OCT) and polarization-sensitive phase-retardation OCT (P-OCT) images are obtained. Three graders grade the visibility of the TM using a four-leveled grading system. The intergrader agreement, intermodality differences, and interquadrant dependence of visibility are statistically examined. All three of three combinations of graders show substantial agreement in visibility with P-OCT (ρ = 0.74, 0.70, and 0.68, Spearman's correlation), while only one of three shows substantial agreement with S-OCT (ρ = 0.72). Significant dependence of the visibility on the modality (S-OCT versus P-OCT) and quadrants are found by the analysis of variance. A subsequent Wilcoxon signed-rank test reveals significantly improved visibility. PS-CAS-OCT may become a useful tool for screening angle-closure glaucoma.
authors.affiliation: University of Tsukuba, Computational Optics Group and Computational Optics and Ophthalmology Group, Ibaraki, Japan. yasuno@optlab2.bk.tsukuba.ac.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamanari
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kawana
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Shuichi
authors.initials: S
authors.lastname: Makita
authors.forename: Shingo
authors.initials: S
authors.lastname: Sakai
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Oshika
mesh_terms: D000328:Adult; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods*; D012031:Refractometry / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D014129:Trabecular Meshwork / Q000033:anatomy & histology*; D055815:Young Adult