title: [Vitamin D and multiple sclerosis. A prospective survey of patients of Poitou-Charentes area].
abstract: BACKGROUND
  Recent reports demonstrate the implication of vitamin D in multiple sclerosis (MS).
  
  
  METHODS
  In a multicentric regional study (Poitou-Charentes area) during the first trimester 2010, we measured the 25-OH vitamin D serum level in 170 consecutive MS patients, and in 170 controls matched for age (±4 years), sex and date of blood sample analysis. We searched for correlations between 25-OH vitamin D serum levels and the MS form, the disability (EDSS), the relapse rate during the previous year and the presence and number of enhancing lesions on T1-weighted MRI dating less than 12 months in relapsing MS.
  
  
  RESULTS
  Hypovitaminosis D was very frequent in MS patients and 25-OH vitamin D serum level was significantly lower (14.5 ± 9.2 mcg/mL) in MS patients than in the control group (16.7 ± 9.6 mcg/mL). This serum level was inversely correlated with the degree of disability measured with EDSS score and was lower in secondary progressive (RR-SP) and primary progressive (PP) MS than in relapsing MS (RR). No correlation was found between 25-OH vit D serum level and relapse rate during the previous year in RR MS and the presence and number of enhancing lesions on T1-weighted MRI dating from less than 12 months.
  
  
  CONCLUSIONS
  25-OH vit D serum level is very low in MS, mainly in RR-SP and PP MS and is correlated with disability. This suggests MS patients should be screened for vitamin D deficiency and given supplementation systematically when hypovitaminosis D is discovered.
authors.affiliation: Service de neurologie, CHU La Milétrie, 2, rue de la Milétrie, 86021 Poitiers cedex 05, France. jph.neau@chu-poitiers.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Neau
authors.forename: M S
authors.initials: MS
authors.lastname: Artaud-Uriot
authors.forename: V
authors.initials: V
authors.lastname: Lhomme
authors.forename: J Y
authors.initials: JY
authors.lastname: Bounaud
authors.forename: F
authors.initials: F
authors.lastname: Lebras
authors.forename: L
authors.initials: L
authors.lastname: Boissonnot
authors.forename: N
authors.initials: N
authors.lastname: Moinot
authors.forename: J
authors.initials: J
authors.lastname: Ciron
authors.forename: D
authors.initials: D
authors.lastname: Larrieu
authors.forename: S
authors.initials: S
authors.lastname: Mathis
authors.forename: G
authors.initials: G
authors.lastname: Godeneche
authors.forename: P
authors.initials: P
authors.lastname: Ingrand
mesh_terms: D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D005260:Female; D005602:France / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000453:epidemiology*; D011446:Prospective Studies; D012008:Recurrence; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D006887:Hydroxycholecalciferols; D014807:Vitamin D