title: [Changes of functional activity of peripheral blood leukocytes during the immunotherapy of tick-borne infections in children].
abstract: We studied the peculiarities of functional activity of peripheral blood leukocytes in different etiological variants and clinical forms of tick-borne infections in 629 children aged from 1 to 14 years. The decrease of biocide potential of neutrophils was accompanied by most severe clinical manifestations. The analysis of changes in defensin levels in different clinical forms of tick-borne infections revealed the most significant changes in cases of mixed infection. The dynamics of functional activity of leukocytes during the cycloferon immunotherapy reflected the effectiveness of recovering process in biocide potential regardless of the infection etiology. The main advantage of immunotherapy is the possibility of its use in the complex treatment before the serologic confirmation of the diagnosis regardless of disease etiology.
authors.forename: T V
authors.initials: TV
authors.lastname: Poponnikova
authors.forename: T N
authors.initials: TN
authors.lastname: Vakhrameeva
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Bedareva
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Galieva
mesh_terms: D000166:Acridines / Q000627:therapeutic use; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D023082:Defensins / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007167:Immunotherapy; D007223:Infant; D007369:Interferon Inducers / Q000627:therapeutic use; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D009504:Neutrophils / Q000276:immunology; D017282:Tick-Borne Diseases / Q000276:immunology / Q000382:microbiology / Q000628:therapy*
chemical_list: D000166:Acridines; D023082:Defensins; D007136:Immunoglobulins; D007155:Immunologic Factors; D007369:Interferon Inducers; C026430:10-carboxymethyl-9-acridanone