title: [Association of serum follicle stimulating hormone with osteoprotegerin, leptin, TGF-β1, and TGF-β2 in women].
abstract: OBJECTIVE
  To determine the relation between follicle-stimulating hormone (FSH) level and bone metabolism-related cytokines in women.
  
  
  METHODS
  A cross-sectional study of 703 healthy Chinese women, aged 20-80 years, was conducted. Serum FSH, osteoprotegerin (OPG), leptin, transforming growth factor-beta 1 (TGF-β1), and transforming growth factor-beta 2 (TGF-β2) were detected.
  
  
  RESULTS
  Serum FSH was positively correlated with OPG (r=0.447, P<0.01) and TGF-β2 (r=0.344, P<0.01), and negatively correlated with TGF-β1 (r=-0.374, P<0.01). After adjustment of age, a negative correlation was found between FSH and leptin (r=-0.265, P<0.01). The multiple linear stepwise regression analysis showed that serum FSH was a negative determinant factor of TGF-β1, and 22.6% changes in TGF-β1 was determined by FSH. FSH was, however, a positive determinant factor of OPG and TGF-β2, and 9.9% and 1.1% of the effect on OPG and TGF-β2 was performed by FSH, respectively. Serum FSH almost had no effect on leptin.
  
  
  CONCLUSIONS
  Serum FSH level in adult women is related to bone metabolism-related cytokines, such as TGF-β1, OPG, and TGF-β2.
authors.affiliation: Institute of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Xie
authors.forename: Xianping
authors.initials: X
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D053781:Transforming Growth Factor beta2 / Q000097:blood*; D055815:Young Adult
chemical_list: D020738:Leptin; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2; D005640:Follicle Stimulating Hormone