title: Successful management of gastrointestinal pythiosis in a dog using itraconazole, terbinafine, and mefenoxam.
abstract: Medical therapy for pythiosis is hampered by a lack of efficacious drugs. The present report describes a case of canine gastrointestinal pythiosis in which lesions were resolved through the administration of itraconazole, terbinafine, and the agricultural fungicide mefenoxam. No substantial adverse effects occurred in association with administration of the latter compound. Additional studies are needed to evaluate the pharmacokinetics of mefenoxam and to further assess its tolerability and potential efficacy for the treatment of pythiosis in dogs.
authors.affiliation: Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA. jimh@vshcarolinas.com
authors.forename: James
authors.initials: J
authors.lastname: Hummel
authors.forename: Amy
authors.initials: A
authors.lastname: Grooters
authors.forename: Gigi
authors.initials: G
authors.lastname: Davidson
authors.forename: Samuel
authors.initials: S
authors.lastname: Jennings
authors.forename: Jodi
authors.initials: J
authors.lastname: Nicklas
authors.forename: Adam
authors.initials: A
authors.lastname: Birkenheuer
mesh_terms: D000409:Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D004285:Dogs; D004386:Duodenum / Q000473:pathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D006651:Histocytochemistry; D017964:Itraconazole / Q000008:administration & dosage / Q000009:adverse effects; D009281:Naphthalenes / Q000008:administration & dosage / Q000009:adverse effects; D058968:Pythiosis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011775:Pythium / Q000302:isolation & purification*; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; C473256:mefenoxam; D000077291:Terbinafine; D000409:Alanine