title: Pre- versus post-column oxidation liquid chromatography fluorescence detection of paralytic shellfish toxins.
abstract: Both pre- and post-column oxidation liquid chromatography methods with fluorescence detection are available for detecting paralytic shellfish toxins. Each method has been evaluated in multiple laboratories and validated as a potential alternative to the mouse bioassay. This communication compares the advantages and limitations of both methods. For a given laboratory, the selection of either method may be based primarily on practicality and less on any deficiencies in scientific merit.
authors.affiliation: Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, Spectroscopy and Mass Spectrometry Branch, US FDA, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA. Stacey.Etheridge@fda.hhs.gov
authors.forename: Stacey L
authors.initials: SL
authors.lastname: DeGrasse
authors.forename: Jeffrey
authors.initials: J
authors.lastname: van de Riet
authors.forename: Robert
authors.initials: R
authors.lastname: Hatfield
authors.forename: Andrew
authors.initials: A
authors.lastname: Turner
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D010084:Oxidation-Reduction; D012530:Saxitoxin / Q000032:analysis*; D057096:Shellfish Poisoning; D013050:Spectrometry, Fluorescence
chemical_list: D012530:Saxitoxin