title: [Current alteration of K(V) channel in SLE patient's peripheral blood lymphocytes and it's significant].
abstract: OBJECTIVE
  To observe the property alteration of K(v) channel in SLE patient's peripheral blood lymphocyte and its significant.
  
  
  METHODS
  The patch-clamp technique was used to record the current of K(V) channel in SLE patient's peripheral lymphocyte.
  
  
  RESULTS
  The current amplitude of K(V) channel in the SLE patient's lymphocytes decreased, it was (258.6 +/- 112.5) pA in healthy people, but in SLE patient it was (139.4 +/- 58.5) pA (P < 0.05). There was no other changes in the property of channel, include activation potential, inactivation property, channel closing kinetics and its pharmacological property.
  
  
  CONCLUSIONS
  The decline of SLE patient's cell immunity may be related to the decrease of the amplitude of K(V) channel current.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Sun
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Guo-Gan
authors.initials: GG
authors.lastname: Zhong
authors.forename: Dong-Xiang
authors.initials: DX
authors.lastname: Zhang
authors.forename: Zhao-Yun
authors.initials: ZY
authors.lastname: Yin
mesh_terms: D016022:Case-Control Studies; D002462:Cell Membrane / Q000502:physiology; D005434:Flow Cytometry; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000502:physiology*; D009000:Monocytes / Q000378:metabolism / Q000502:physiology; D018408:Patch-Clamp Techniques; D024642:Potassium Channels, Voltage-Gated / Q000502:physiology*
chemical_list: D024642:Potassium Channels, Voltage-Gated