title: [Expression of pituitary tumor transforming gene in patients with AML].
abstract: The aim of study was to explore the expression of pituitary tumor-transforming gene (pttg) in acute myeloid leukemia (AML) and its relationship with the pathogenesis of AML, simultaneously to investigate the difference of the pttg expression among AML different subtypes. The expressions of pttg mRNA were quantitatively detected by real-time fluorescence quantitative polymerase chain reaction (real-time PCR) in bone marrow from 47 patients with AML and 28 normal controls. The results indicated that the expression of pttg mRNA was significantly higher in AML patients [(1.1323 ± 1.3934) × 10(5)] than that in normal controls [(4.5766 ± 1.1817) × 10(3)] (p < 0.05). The expression of pttg mRNA was higher in M(3) patients than that in other AML subtypes, such as M(1), M(2), M(4), M(5). It is concluded that the overexpression of pttg may be related to the pathogenesis and progression of AML, in which the overexpression of pttg may be more intimately related to the pathogenesis and progression of M(3). This study provides a new idea to research the pathogenesis and targeted gene therapy of AML.
authors.affiliation: Department of Hematology, Xiamen University, Xiamen 361004, Fujian Province, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.forename: Quan-Yi
authors.initials: QY
authors.lastname: Lu
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Niu
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Jiang-Ning
authors.initials: JN
authors.lastname: Zhao
authors.forename: Ke-Jie
authors.initials: KJ
authors.lastname: Zhang
authors.forename: Pu
authors.initials: P
authors.lastname: Li
authors.forename: Jia-Sheng
authors.initials: JS
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D064249:Securin; D055815:Young Adult
chemical_list: D009363:Neoplasm Proteins; D012333:RNA, Messenger; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human