title: Synthesis of isoxazoline N-oxides via [hydroxy(tosyloxy)iodo]benzene (HTIB)-mediated oxidative N-O coupling.
abstract: An HTIB mediated oxidative N-O coupling strategy for the synthesis of some isoxazoline N-oxide derivatives from β-hydroxyketoximes is described, along with a comparative study of the efficiency of N-O coupling in two different solvents. A plausible mechanism for the conversion is proposed.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, Taiwan 116, Republic of China.
authors.forename: Mustafa J
authors.initials: MJ
authors.lastname: Raihan
authors.forename: Veerababurao
authors.initials: V
authors.lastname: Kavala
authors.forename: Pateliya Mujjamil
authors.initials: PM
authors.lastname: Habib
authors.forename: Qiao-Zhi
authors.initials: QZ
authors.lastname: Guan
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Kuo
authors.forename: Ching-Fa
authors.initials: CF
authors.lastname: Yao
mesh_terms: D003461:Crystallography; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D058451:Oxidative Coupling; D012997:Solvents / Q000737:chemistry; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: C526017:(hydroxy(tosyloxy)iodo)benzene; D003497:Cyclic N-Oxides; D007462:Iodobenzenes; D007555:Isoxazoles; D012997:Solvents; D014105:Tosyl Compounds