title: [Protective effects of captopril against lung injury in rats with severe acute pancreatitis].
abstract: OBJECTIVE
  To investigate the protective effects of captopril against lung injury in a rat model of severe acute pancreatitis (SAP).
  
  
  METHODS
  Seventy-two male SD rats were randomized into sham-operated group (SO group), SAP group and captopril intervention group (CAP group). Serum amylase and myeloperoxidase (MPO) activity in the lung tissue were examined at 1, 6 and 12 h after the operation. TNF-α and AngII in the lung tissue were detected by ELISA, and the histopathological changes of the pancreas and lung were observed microscopically.
  
  
  RESULTS
  The MPO activity , which was similar between SAP group and CAP group at 1 h, were significantly lowered in CAP group at 6 and 12 h (P<0.05). Serum amylase level and the levels of TNF-α and AngII in the lung tissue homogenate were all reduced significantly in CAP group as compared to those in SAP group (P<0.01). The pathological injury of the lung was obviously lessened in CAP group in comparison with that in SAP group.
  
  
  CONCLUSIONS
  Captopril can ameliorate SAP-induced lung injury in rats.
authors.affiliation: Department of General Surgery, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, China. lishunle@sina.com
authors.forename: Shun-le
authors.initials: SL
authors.lastname: Li
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Xin-wu
authors.initials: XW
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Zong-zheng
authors.initials: ZZ
authors.lastname: Ji
mesh_terms: D000681:Amylases / Q000097:blood; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D008168:Lung / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D010195:Pancreatitis / Q000150:complications* / Q000188:drug therapy; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D000804:Angiotensin II; D002216:Captopril; D009195:Peroxidase; D000681:Amylases