title: Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines.
abstract: Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.
authors.affiliation: Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, 10065, USA. sjiang@nybloodcenter.org.|School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. sjiang@nybloodcenter.org.
authors.forename: Shibo
authors.initials: S
authors.lastname: Jiang
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Runming
authors.initials: R
authors.lastname: Li
authors.affiliation: Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, 10065, USA.
authors.forename: Lanying
authors.initials: L
authors.lastname: Du
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. liusw@smu.edu.cn.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Liu
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D058872:Epidemics; D006388:Hemagglutinins / Q000502:physiology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000628:therapy; D058873:Pandemics
chemical_list: D000998:Antiviral Agents; D006388:Hemagglutinins; D007252:Influenza Vaccines