title: [Indirect and direct effects of absorption components of composite for activating blood and removing stasis on coronary microvascular dysfunction and myocardial cell apoptosis].
abstract: It has been found that in case of targeted for coronary microvascular dysfunction and myocardial cell apoptosis, the anti-apoptosis effect of Guanxin No. 2, a Chinese herbal composite for activating blood and removing stasis (ABRS), is identical to that of its three absorption components (ferulic acid, Danshensu and hydroxylcarthamin yellow), and there exists a dose/myocardial flow-dependent direct or indirect acting path. Based on which, a hypothesis regarding the dose/myocardial flow related direct/indirect action of Chinese ABRS composite, with the same targets as before, was put forward by the authors in this paper, that is, the myocardial protective effect of acute high dose administration of the composite is acted through indirectly path by increasing the myocardial flow (MF); while that of chronic low dose administration is realized directly without change of MF. The evidence and significance of this hypothesis were discussed.
authors.affiliation: Institute of Integrated Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha. tcmhuangx59@163.com
authors.forename: Xi
authors.initials: X
authors.lastname: Huang
authors.forename: Feng
authors.initials: F
authors.lastname: Qin
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D008833:Microcirculation / Q000502:physiology; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000473:pathology*; D008517:Phytotherapy; D051381:Rats
chemical_list: D004365:Drugs, Chinese Herbal; C534196:guan xin II