title: Biological activities of Fructus arctii fermented with the basidiomycete Grifola frondosa.
abstract: Fructus arctii extract containing phenolic glycosides was cultured with Grifola frondosa mycelia to produce β-glucosidase and its biological activities were studied. This β-glucosidase converted the glycosides (arctiin and caffeic acid derivatives) into aglycones (arctigenin and caffeic acid). Fermented Fructus arctii extract (G-FAE) with G. frondosa had antioxidant and 5-lipoxygenase inhibitory activities. The photoprotective potential of G-FAE was tested in human dermal fibroblasts (HDF) exposed to ultra-violet A (UVA). It was revealed that G-FAE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDF. The treatment of UVA-irradiated HDF with G-FAE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. G-FAE also showed notable stimulation of collagen biosynthetic activity for fibroblasts. These diverse functionalities suggest that G-FAE could be a promising cosmetic ingredient.
authors.affiliation: R & D Center, Hanbul Cosmetics Co., Umsung 369-834, Korea.
authors.forename: Jin-Hwa
authors.initials: JH
authors.lastname: Kim
authors.forename: Jun-Tae
authors.initials: JT
authors.lastname: Bae
authors.forename: Min-Hyeon
authors.initials: MH
authors.lastname: Song
authors.forename: Geun-Su
authors.initials: GS
authors.lastname: Lee
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Choe
authors.forename: Hyeong-Bae
authors.initials: HB
authors.lastname: Pyo
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D031170:Arctium / Q000378:metabolism*; D002478:Cells, Cultured; D003358:Cosmetics / Q000737:chemistry*; D020405:Dermis / Q000187:drug effects; D005285:Fermentation; D005347:Fibroblasts / Q000187:drug effects; D048691:Grifola / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D025282:Mycelium / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014466:Ultraviolet Rays; D001617:beta-Glucosidase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D003358:Cosmetics; D016859:Lipoxygenase Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D012333:RNA, Messenger; D008084:Lipoxygenase; D001617:beta-Glucosidase; D020781:Matrix Metalloproteinase 1