title: Antagonistic effects of gestational dietary exposure to low-dose vinclozolin and genistein on rat fetal germ cell development.
abstract: Continuous, low-dose exposure to a phytoestrogen (1 mg/kg/day genistein) and/or to an antiandrogenic food contaminant (1 mg/kg/day vinclozolin) has been recently reported to affect male reproductive tract and fertility [1] in adults. We investigated whether alterations of the testis are already present at the end of in utero exposure using the same rat model and doses following exposure from conception to delivery. After vinclozolin exposure, we observed in the neonate a slight but significant alteration of steroidogenesis and gametogenesis with a reduction of testosterone secretion and of the number of gonocytes. In contrast, genistein exposure had no effect. While the vinclozolin-genistein mixture acts in a synergistic manner to induce the most significant alterations in the adult, interestingly, genistein antagonized the deleterious effect of vinclozolin on germ cells in the neonate. This difference emphasizes the importance of studying the effects of endocrine disruptors during various developmental stages to understand their effects.
authors.affiliation: Laboratory of Gonad Differentiation and Radiobiology, Stem Cells and Radiation Service, Institute of Cellular and Molecular Radiation Biology, Life Sciences Division, Commissariat à l'Energie Atomique, BP 6, 92265 Fontenay-aux-Roses, France
authors.forename: Abdelali
authors.initials: A
authors.lastname: Lehraiki
authors.forename: Sébastien
authors.initials: S
authors.lastname: Messiaen
authors.forename: Raymond
authors.initials: R
authors.lastname: Berges
authors.forename: Marie-Chantal
authors.initials: MC
authors.lastname: Canivenc-Lavier
authors.forename: Jacques
authors.initials: J
authors.lastname: Auger
authors.forename: René
authors.initials: R
authors.lastname: Habert
authors.forename: Christine
authors.initials: C
authors.lastname: Levacher
mesh_terms: D000367:Age Factors; D000375:Aging; D000726:Androgen Antagonists / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004347:Drug Interactions; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D019833:Genistein / Q000633:toxicity*; D005865:Gestational Age; D008297:Male; D010080:Oxazoles / Q000633:toxicity*; D048789:Phytoestrogens / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D039401:Prenatal Nutritional Physiological Phenomena; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000378:metabolism
chemical_list: D000726:Androgen Antagonists; D052244:Endocrine Disruptors; D010080:Oxazoles; D048789:Phytoestrogens; D013739:Testosterone; D019833:Genistein; C025643:vinclozolin