title: Chemical characterization of various fractions of leaves of Cinnamomum tamala Linn toward their antioxidant, hypoglycemic, and anti-inflammatory property.
abstract: Cinnamomum tamala (CT) Linn. (Lauraceae) is a component of Indian spices and is also used as antidiabetic agent. Its antioxidant potential was reported by other authors and recently our group has reported its immune-suppressive property. Here, CT leaves were extracted with methanol (CTT) and also with various organic solvents of increasing polarity such as hexane (CTH), ethyl acetate (CTEA), and methanol (CTE) in successive manner by continuous Soxhlet extractor. The active compounds of CTT and CTH were analyzed by GC-MS and most abundant compound (eugenol) was further analyzed by HPLC. These extracts were tested for their free radical (FR) scavenging potential for different FR species, hypoglycemic potential on alloxan-induced hyperglycemia, and anti-inflammatory property in carrageenan-induced paw edema and lipopolysaccharide (LPS)-induced nitric oxide (NO) production in rat peritoneal macrophage culture. Result showed that CTH was the most active fraction toward these parameters, which was parallel to its eugenol and total phenolic content concentration.
authors.affiliation: Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors.forename: J K
authors.initials: JK
authors.lastname: Chaurasia
authors.forename: Yamini B
authors.initials: YB
authors.lastname: Tripathi
mesh_terms: D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D002478:Cells, Cultured; D027424:Cinnamomum / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D016166:Free Radical Scavengers / Q000494:pharmacology; D006586:Hexanes / Q000737:chemistry; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D000432:Methanol / Q000737:chemistry; D009569:Nitric Oxide / Q000378:metabolism; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D006586:Hexanes; D007004:Hypoglycemic Agents; D008070:Lipopolysaccharides; D010636:Phenols; D010936:Plant Extracts; D009569:Nitric Oxide; D000496:Alloxan; D002351:Carrageenan; D000432:Methanol