title: Remifentanil in critically ill cardiac patients.
abstract: Remifentanil has a unique pharmacokinetic profile, with a rapid onset and offset of action and a plasmatic metabolism. Its use can be recommended even in patients with renal impairment, hepatic dysfunction or poor cardiovascular function. A potential protective cardiac preconditioning effect has been suggested. Drug-related adverse effects seem to be comparable with other opioids. In cardiac surgery, many randomized controlled trials demonstrated that the potential benefits of the use of remifentanil not only include a profound protection against intraoperative stressful stimuli, but also rapid postoperative recovery, early weaning from mechanical ventilation, and extubation. Remifentanil shows ideal properties of sedative agents being often employed for minimally invasive cardiologic techniques, such as transcatheter aortic valve implantation and radio frequency treatment of atrial flutter, or diagnostic procedures such as transesophageal echocardiography. In intensive care units remifentanil is associated with a reduction in the time to tracheal extubation after cessation of the continuous infusion; other advantages could be more evident in patients with organ dysfunction. Effective and safe analgesia can be provided in case of short and painful procedures (i.e. chest drain removal). In conclusion, thanks to its peculiar properties, remifentanil will probably play a major role in critically ill cardiac patients.
authors.affiliation: Department of Anesthesia and Intensive Care Medicine, Università Vita-Salute San Raffaele, Milan, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Ruggeri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Landoni
authors.forename: Fabio
authors.initials: F
authors.lastname: Guarracino
authors.forename: Sabino
authors.initials: S
authors.lastname: Scolletta
authors.forename: Elena
authors.initials: E
authors.lastname: Bignami
authors.forename: Alberto
authors.initials: A
authors.lastname: Zangrillo
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D000758:Anesthesia / Q000379:methods; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D006348:Cardiac Surgical Procedures; D016638:Critical Illness; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007362:Intensive Care Units; D010880:Piperidines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077208:Remifentanil
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D010880:Piperidines; D000077208:Remifentanil