title: Evaluation of immunomodulatory potential of ethanolic extract of Roscoea procera rhizomes in mice.
abstract: OBJECTIVE
  The aim of present study was to evaluate immunomodulatory potential of ethanolic extract of Roscoea procera (Zingiberaceae) rhizomes by using delayed-type hypersensitivity (DTH) and carbon clearance method in comparison to standard established immunosuppressant drug, cyclophosphamide (30 mg/kg, i.p.) in mice.
  
  
  METHODS
  The extract was comprised to acute toxicity (OECD-423 guideline), DTH and carbon clearance method for their immunomodulatory potential. Ethanolic extract of Roscoea procera rhizomes administered orally at doses 300 mg/kg and 600 mg/kg, p.o. to mice.
  
  
  CONCLUSIONS
  Result of our study revealed that, the foot pat thickness of ethanolic extract group (P<0.05) significantly enhanced the production of circulating antibody titre in response to Sheep red blood cells (SRBC) and phagocytic functions of mononuclear macrophages and non-specific immunity. Result were also supported by serological and haematological tests data. Hence, the present investigation reveals that, ethanolic extract of Roscoea procera rhizomes possesses immunostimulant properties. Further studies to identify the active moieties and elucidation of the mechanism of action are recommended.
authors.affiliation: Department of Pharmacognosy, Radharaman Institute of Pharmaceutical Sciences and Radharaman College of Pharmacy, Ratibad, Bhopal-462044, Madhya Pradesh, India.
authors.forename: Mahesh S
authors.initials: MS
authors.lastname: Sahu
authors.forename: Prashant Y
authors.initials: PY
authors.lastname: Mali
authors.forename: Shekhar B
authors.initials: SB
authors.lastname: Waikar
authors.forename: Vinod D
authors.initials: VD
authors.lastname: Rangari