title: [Neuropathologic investigation of area tempestas sclerosis in epileptic sensitive rats].
abstract: OBJECTIVE
  The relation between AT sclerosis (loss of neurons and proliferation of astrocytes) and long-lasting epileptic susceptibility was investigated by thionine staining, GFAP immunohistochemistry and observing the behavior of rats, after scorpion venom (SV) or normal saline (NS) administrated for three week.
  
  
  RESULTS
  Compared with NS+ NS group, both the loss of neurons and proliferation of astrocytes were very marked in KA+ NS group (epileptic susceptible rats) (P < 0.05), but those changes were not visible in KA+ NS group (epileptic nonsusceptible rats).
  
  
  CONCLUSIONS
  It suggested that AT sclerosis may be one of important reasons of the long-lasting epileptic susceptibility.
authors.affiliation: Department of Physiology, Dalian Medical University, Dalian 116027, China.
authors.forename: Xin-Lu
authors.initials: XL
authors.lastname: Du
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Wan-Qin
authors.initials: WQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000473:pathology*; D004827:Epilepsy / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005904:Glial Fibrillary Acidic Protein