title: [Effects of acute hypoxia on plasma metabolome in mice].
abstract: OBJECTIVE
  To explore the metabolic effects of acute hypoxia on mice plasma.
  
  
  METHODS
  Fourteen mice were randomly divided into two groups: control and hypoxia group. The mice of hypoxia group were exposed to a simulated altitude of 6000 meters for 8 hours. Nuclear magnetic resonance spectrometer was used to identify the metabolic changes after acute hypoxia.
  
  
  RESULTS
  Compared with control, the most notable significantly after acute hypoxia exposure. remarkably and lactate increased metabolic changes in plasma were as follows: camrnitine decreased levels of lipids and pyruvate, alanine, taurine, Decreases in levels of beta-HB, ethanol glycerol, glutamate, glycine and serine, and increased choline, glucose, and glutamine were also observed in hypoxia group.
  
  
  CONCLUSIONS
  Significant changes in the plasma carbohydrate, lipid and amino acid profiles were observed following acute hypoxia, suggesting a hypoxia-induced alteration in energy and related substances metabolism.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medieal Sciences, Tianjin 300050, China.
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Chang-jiang
authors.initials: CJ
authors.lastname: Guo
authors.forename: Ji-jun
authors.initials: JJ
authors.lastname: Yang
authors.forename: Jing-yu
authors.initials: JY
authors.lastname: Wei
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xian-zhong
authors.initials: XZ
authors.lastname: Yan
mesh_terms: D000208:Acute Disease; D000531:Altitude; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D055442:Metabolome / Q000502:physiology*; D055432:Metabolomics / Q000379:methods; D051379:Mice; D011897:Random Allocation
chemical_list: D001798:Blood Proteins