title: Factors affecting the stability of blood lipid and lipoprotein levels from youth to adulthood: evidence from the Childhood Determinants of Adult Health Study.
abstract: OBJECTIVE
  To examine the effect of lifestyle changes on the stability of blood lipid and lipoprotein levels from youth to adulthood.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Australia.
  
  
  METHODS
  Five hundred thirty-nine young adults who underwent measurement at baseline in 1985 when aged 9, 12, or 15 years and again at follow-up between 2004 and 2006.
  
  
  METHODS
  Changes in adiposity, cardiorespiratory fitness, saturated fat intake, smoking, and socioeconomic position.
  
  
  METHODS
  Child and adult blood lipid levels.
  
  
  RESULTS
  Using established cut points, we found that substantial proportions of individuals with high-risk blood lipid and lipoprotein levels at baseline no longer had high-risk levels at follow-up. Of the participants who had high-risk levels in youth, those with greater increases in adiposity or who commenced or continued smoking were more likely to maintain high-risk blood lipid and lipoprotein levels (P < .05). Participants who became high risk at follow-up had greater increases in adiposity, were less likely to improve their socioeconomic position, and tended to become less fit between surveys compared with those who maintained normal-risk levels (P ≤ .05). These effects tended to remain (P ≤ .10) after adjustment for all predictive lifestyle variables.
  
  
  CONCLUSIONS
  Unhealthy lifestyle changes that occur between youth and adulthood affect whether an individual maintains, loses, or develops high-risk blood lipid and lipoprotein levels in adulthood. Interventions that promote weight control in the first instance, but also physical activity, not smoking, and improved socioeconomic position in the transition from youth to adulthood, are likely to be of benefit in preventing adult dyslipidemia.
authors.affiliation: Menzies Research Institute, University of Tasmania, Hobart, Australia. cmagnuss@utas.edu.au
authors.forename: Costan G
authors.initials: CG
authors.lastname: Magnussen
authors.forename: Russell
authors.initials: R
authors.lastname: Thomson
authors.forename: Verity J
authors.initials: VJ
authors.lastname: Cleland
authors.forename: Obioha C
authors.initials: OC
authors.lastname: Ukoumunne
authors.forename: Terence
authors.initials: T
authors.lastname: Dwyer
authors.forename: Alison
authors.initials: A
authors.lastname: Venn
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001294:Attitude to Health; D001315:Australia / Q000453:epidemiology; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D050171:Dyslipidemias / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins