title: Can mean platelet volume predict coronary vasospasm?
abstract: Mean platelet volume (MPV) is an index of platelet function that reflects platelet production rate and sensitivity to activation. The relationship between MPV and coronary vasospasm has not been previously studied. In this study, we aimed to evaluate this relationship. A total of 696 patients (age 55.20 ± 12.26, male 46.4%, female 53.6%) with typical or atypical angina who underwent diagnostic coronary angiography (CAG) and an acetylcholine (Ach)-provocation test were enrolled. Each patient was assigned to either an Ach-induced coronary vasospasm group (n = 183) or a control group (n = 513). We compared MPV between the two groups. MPV and the platelet count showed a negative correlation (r = -0.289, p < 0.001). MPV was higher in the Ach-induced coronary vasospasm group than in the control group (9.03 ± 1.37 fl and 8.69 ± 1.25 fl, respectively, p = 0.002). In multivariate analysis, MPV independently predicted Ach-induced coronary vasospasm (OR = 1.188, p = 0.018). This study identified high MPV as an independent risk factor for Ach-induced coronary vasospasm.
authors.affiliation: Cardiovascular Center, Korea University, Guro Hospital, Seoul, South Korea.
authors.forename: Cheol Ung
authors.initials: CU
authors.lastname: Choi
authors.forename: Hong Seog
authors.initials: HS
authors.lastname: Seo
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Na
authors.forename: Hong Euy
authors.initials: HE
authors.lastname: Lim
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Eung Ju
authors.initials: EJ
authors.lastname: Kim
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.forename: Chang Gyu
authors.initials: CG
authors.lastname: Park
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Oh
mesh_terms: D000109:Acetylcholine; D001792:Blood Platelets / Q000502:physiology*; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000379:methods; D003329:Coronary Vasospasm / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D000109:Acetylcholine