title: Coupling temperature sensing and development: Hsp90 regulates morphogenetic signalling in Candida albicans.
abstract: Hsp90 is environmentally contingent molecular chaperone that influences the form and function of diverse signal transducers. Here we discuss our recent findings that Hsp90 regulates the morphogenetic transition from yeast to filamentous forms required for virulence of the most prevalent fungal pathogen of humans, Candida albicans, and does so via cAMP-PKA signalling. This transition is normally regulated by environmental cues that are contingent upon elevated temperature to relieve Hsp90-mediated repression of the morphogenetic program. Intriguingly, Hsp90 inhibition induces filamentation independent of the canonical PKA transcription factor Efg1, in striking similarity to a select set of morphogenetic stimuli. Further investigation will determine the downstream transcription factors through which Hsp90 regulates morphogenesis and the precise mechanism of Hsp90's interaction with the cAMP-PKA pathway. C. albicans is one of many fungal species that undergo a morphological transition in a temperature-dependent manner, thus Hsp90's capacity to govern this key developmental program may provide insight into morphogenesis of diverse organisms.
authors.affiliation: Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
authors.forename: R S
authors.initials: RS
authors.lastname: Shapiro
authors.forename: Leah
authors.initials: L
authors.lastname: Cowen
mesh_terms: D002176:Candida albicans / Q000254:growth & development* / Q000502:physiology / Q000528:radiation effects*; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D025301:Hyphae / Q000254:growth & development; D008954:Models, Biological; D015398:Signal Transduction; D013696:Temperature
chemical_list: D005656:Fungal Proteins; D018841:HSP90 Heat-Shock Proteins; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases