title: 2009 Influenza A H1N1 infections: delays in starting treatment with oseltamivir were associated with a more severe disease.
abstract: Respiratory failure has been the main severe complication described in pediatric patients with influenza A H1N1 2009 (pandemic H1N1) infection. We describe the pandemic H1N1 2009 disease in children who required hospital admission and the patients' data associated with pediatric intensive care unit admission. Respiratory failure was the main complication. Extrapulmonary manifestations were also observed. Of the 127 patients, 24 required pediatric intensive care unit admission. Four patients died. Patients admitted with chronic conditions and those in whom oseltamivir was delayed more than 72 hours had a more severe disease.
authors.affiliation: Infectious Diseases Unit, Department of Pediatrics, Hospital Universitari Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain. claunes@hsjdbcn.org
authors.forename: Cristian
authors.initials: C
authors.lastname: Launes
authors.forename: Juan-José
authors.initials: JJ
authors.lastname: García-García
authors.forename: Iolanda
authors.initials: I
authors.lastname: Jordán
authors.forename: Aina
authors.initials: A
authors.lastname: Martínez-Planas
authors.forename: Laura
authors.initials: L
authors.lastname: Selva
authors.forename: Carmen
authors.initials: C
authors.lastname: Muñoz-Almagro
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000706:statistics & numerical data; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology*; D008297:Male; D053139:Oseltamivir / Q000008:administration & dosage*; D012131:Respiratory Insufficiency / Q000453:epidemiology; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir