title: The effects of 2 week senofilcon-A silicone hydrogel contact lens daily wear on tear functions and ocular surface health status.
abstract: OBJECTIVE
  To prospectively investigate the effects of 2 week senofilcon A contact lens (CL) daily wear on the functional visual acuity (VA), ocular surface and tear film.
  
  
  METHODS
  Seventeen right eyes of 17 senofilcon A CL wearers without any ocular or systemic diseases were examined before and 2 weeks after lens wear. Visual acuity measurements, tear evaporation rate, ELISA for tear cytokines, strip meniscometry, tear lipid layer interferometry, tear film break-up time (BUT), in vivo confocal microscopy, corneal sensitivity, ocular surface vital staining, Schirmer I test and brush cytology for MUC5AC mRNA expression were performed before and after CL wear.
  
  
  RESULTS
  The best corrected Landolt VA, functional VA parameters, the mean lipid layer interferometry grades, tear evaporation rates, Schirmer test values, vital staining scores and in vivo confocal microscopy parameters did not show any significant differences after 2 weeks of CL wear. The tear film BUT showed a significant decrease together with a significant down regulation of MUC5 AC mRNA expression after CL wear. A statistically significant elevation in the mean tear interleukin (IL)-6 concentration was also observed after 2 weeks of CL wear.
  
  
  CONCLUSIONS
  Two week senofilcon A daily CL wear seems to be associated with tear instability, a decrease in MUC5AC expression, and elevation of IL-6 in tears without significant alterations in epithelial damage scores or in the morphology or density of in vivo keratoconjunctival cells and nerves. Alterations associated with long term wear and patients with dry eye disease need to be studied in future trials.
authors.affiliation: Keio University School of Medicine, Johnson and Johnson Department of Ocular Surface and Visual Optics, Shinanomachi, Shinjuku-ku, Tokyo, Japan. muratodooru@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Samantha K
authors.initials: SK
authors.lastname: Ward
authors.forename: Tais
authors.initials: T
authors.lastname: Wakamatsu
authors.forename: Osama
authors.initials: O
authors.lastname: Ibrahim
authors.forename: Cristina
authors.initials: C
authors.lastname: Schnider
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Junko
authors.initials: J
authors.lastname: Ogawa
authors.forename: Jun
authors.initials: J
authors.lastname: Shimazaki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000328:Adult; D003228:Conjunctiva / Q000166:cytology*; D003263:Contact Lenses, Hydrophilic; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D020100:Hydrogels; D008055:Lipids / Q000737:chemistry; D008297:Male; D055271:Mucin 5AC / Q000378:metabolism; D011446:Prospective Studies; D012828:Silicones; D013666:Tears / Q000502:physiology*; D013997:Time Factors; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D016207:Cytokines; D005136:Eye Proteins; D020100:Hydrogels; D008055:Lipids; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D012828:Silicones; C523196:senofilcon A; C042434:tear proteins