title: Noise cancellation: viral fine tuning of the cellular environment for its own genome replication.
abstract: Productive replication of DNA viruses elicits host cell DNA damage responses, which cause both beneficial and detrimental effects on viral replication. In response to the viral productive replication, host cells attempt to attenuate the S-phase cyclin-dependent kinase (CDK) activities to inhibit viral replication. However, accumulating evidence regarding interactions between viral factors and cellular signaling molecules indicate that viruses utilize them and selectively block the downstream signaling pathways that lead to attenuation of the high S-phase CDK activities required for viral replication. In this review, we describe the sophisticated strategy of Epstein-Barr virus to cancel such "noisy" host defense signals in order to hijack the cellular environment.
authors.affiliation: Division of Virology, Aichi Cancer Center Research Institute, Nagoya, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Sato
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Tsurumi
mesh_terms: D018844:Cyclin-Dependent Kinases; D004261:DNA Replication / Q000276:immunology*; D004279:DNA, Viral / Q000502:physiology*; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D004279:DNA, Viral; D018844:Cyclin-Dependent Kinases