title: Synthesis and reactivity of highly nucleophilic pyridines.
abstract: 3,4,5-Triamino-substituted pyridines are avid for electrophiles but are still willing to give them back. In these compounds three amino groups conjoin their forces into the heterocyclic nitrogen, making it a powerful Lewis base. A short and efficient synthesis is described, and the origin of its unique activity in nucleophilic organocatalysis is rationalized by kinetics and thermodynamic quantifications.
authors.affiliation: UniverSud Paris, Institut Lavoisier, Université de Versailles St. Quentin-en-Yvelines, UMR 8180, 45 avenue des Etats-Unis, 78035, Versailles, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: De Rycke
authors.forename: Guillaume
authors.initials: G
authors.lastname: Berionni
authors.forename: François
authors.initials: F
authors.lastname: Couty
authors.forename: Herbert
authors.initials: H
authors.lastname: Mayr
authors.forename: Regis
authors.initials: R
authors.lastname: Goumont
authors.forename: Olivier R P
authors.initials: OR
authors.lastname: David