title: [Research progress on second-hit in malignant lymphomagenesis-- review].
abstract: Stem/progenitor cells contribute to normal development of organs, but their mutation may lead to many human diseases including cancer. Stem/progenitor cells and some of the cancer cells have the same abilities of self-renewal and differentiation, suggesting that tumors were initiated from mutated stem/progenitor cells, the cancer stem/progenitor cells. The recent studies on the origin of the non-Hodgkin's lymphomas has proved that the second-hit aggravates gene mutation in lymphocytic progenitor cells, leading to the generation of lymphoma. This review summarizes the current advances in the studies of the second-hit at stem/progenitor cells in oncogenesis of B-cell non-Hodgkin's lymphoma.
authors.affiliation: Department of Hematology, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Li
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Li
mesh_terms: D006801:Humans; D007938:Leukemia / Q000209:etiology; D008223:Lymphoma / Q000209:etiology*; D009154:Mutation; D014411:Neoplastic Stem Cells / Q000166:cytology*