title: Clinical implications of methicillin-resistant Staphylococcus aureus in pregnancy.
abstract: OBJECTIVE
  Methicillin-resistant Staphylococcus aureus (MRSA) has become an increasingly aggressive and prevalent pathogen in medicine. This pattern has also been noted in obstetrics. This review will delineate the epidemiology and clinical implications of MRSA during pregnancy.
  
  
  RESULTS
  Investigations have focused on prevalence of MRSA colonization in obstetrics and the associated morbidity. In addition, some attention has been focused on the neonatal implications of maternal colonization. Overall, the rates of maternal MRSA colonization noted in the United States have been low, in the range of 0.5-4%. The clinical impact of MRSA colonization among pregnant women has also been estimated to be modest. Roughly 357 invasive MRSA infections per 100,000 live births in the United States occur on an annual basis. It is however important to note that published estimates likely underestimate the full scope of MRSA in pregnancy given the lack of formal reporting, importance of related neonatal colonization and morbidity, the complicated treatment implications in pregnant women, the recognized high pathogenicity of MRSA infections, and propensity for recurrent infections among community-acquired MRSA strains.
  
  
  CONCLUSIONS
  MRSA is an increasingly important pathogen in modern healthcare and in the obstetric population. Continued surveillance and research remains a top priority.
authors.affiliation: Divisions of Reproductive Infectious Diseases and Obstetric Specialties, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. rbeigi@mail.magee.edu
authors.forename: Richard H
authors.initials: RH
authors.lastname: Beigi
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000175:diagnosis; D005260:Female; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000378:metabolism*; D009774:Obstetrics / Q000379:methods; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D011256:Pregnancy Outcome; D012306:Risk; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis*
chemical_list: D000890:Anti-Infective Agents