title: [Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals].
abstract: OBJECTIVE
  To study effects of proanthocyanidins (PA) on contractile activity of isolated aortic smooth muscle in rats and rabbit platelet aggregation.
  
  
  METHODS
  Isolated rat aortic muscle rings were adopted to observe the effects of PA on their contraction induced by noradrenaline (NA) or KCl, and their tensions were recorded by BL-310 experimental system of biological function. Rabbit platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP), and collagen (Coll) was assayed by turbidimetry.
  
  
  RESULTS
  PA could significantly inhibit the contraction induced by NA (10(-6) mol/L), low the concentration-response curves of NA and the maximal response on the endothelium-intact or endothelium-denuded aortic rings. But PA couldn't relax the aortic rings precontracted with KCl and had no influence on rabbit platelet aggregation induced by AA, ADP, and Coll.
  
  
  CONCLUSIONS
  PA can inhibit the contraction induced by NA but not by KCl on isolated rat aortic rings. It also has no influence on rabbit platelet aggregation.
authors.affiliation: Department of Physiology, College of Basic Medicine, Lanzhou University, Lanzhou 730000, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Zhang
authors.forename: Wen-Guang
authors.initials: WG
authors.lastname: Li
authors.forename: Tian-Zhen
authors.initials: TZ
authors.lastname: Zheng
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D044945:Proanthocyanidins / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D027843:Vitis / Q000737:chemistry
chemical_list: D044945:Proanthocyanidins; D011189:Potassium Chloride; D009638:Norepinephrine