title: Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa.
abstract: By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their chemical structures were elucidated by mass, 1D, and 2D NMR spectroscopies. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity methods. Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5μM Trolox equivalents at the concentration of 2.0μM. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4μM.
authors.affiliation: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors.forename: Van Kiem
authors.initials: VK
authors.lastname: Phan
authors.forename: Xuan Cuong
authors.initials: XC
authors.lastname: Nguyen
authors.forename: Xuan Nhiem
authors.initials: XN
authors.lastname: Nguyen
authors.forename: Kim Thu
authors.initials: KT
authors.lastname: Vu
authors.forename: Khac Ban
authors.initials: KB
authors.lastname: Ninh
authors.forename: Van Minh
authors.initials: VM
authors.lastname: Chau
authors.forename: Huu Tai
authors.initials: HT
authors.lastname: Bui
authors.forename: Nam Hai
authors.initials: NH
authors.lastname: Truong
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Hae Dong
authors.initials: HD
authors.lastname: Jang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002839:Chromans / Q000494:pharmacology; D030681:Ficus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D000975:Antioxidants; C421808:C-glucosylflavone; D002839:Chromans; D005419:Flavonoids; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid