title: [Therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion(SMAO) shock].
abstract: OBJECTIVE
  To study preventive and therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion (SMAO) shock and their mechanism of action.
  
  
  METHODS
  Model of rabbit SMAO shock was made. The effect of zinc sulfate on the malondialdehyde (MDA) in erythrocyte membrane and plasma, oxidase (XOD) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate were observed.
  
  
  RESULTS
  The administration of zinc sulfate decreased MDA and XOD, prevented the reduction of SOD and PS, and alleviated lung injury.
  
  
  CONCLUSIONS
  It is suggested that lung is injured during SMAO shock and zinc sulfate possesses preventive and therapeutic effect, through stabilized membrane.
authors.affiliation: Department of Physiology, North Coal Medical College, Tangshan 063000, China.
authors.forename: You-Ling
authors.initials: YL
authors.lastname: Jing
authors.forename: Chun-Xiu
authors.initials: CX
authors.lastname: Zhao
authors.forename: Guo-Xian
authors.initials: GX
authors.lastname: Duan
authors.forename: Yan-Lei
authors.initials: YL
authors.lastname: Wang
authors.forename: Yong-Qi
authors.initials: YQ
authors.lastname: Hu
authors.forename: Lian-Yuan
authors.initials: LY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005260:Female; D008168:Lung / Q000378:metabolism; D055370:Lung Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D017538:Mesenteric Artery, Superior / Q000473:pathology; D008641:Mesenteric Vascular Occlusion / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D011817:Rabbits; D012769:Shock / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D019287:Zinc Sulfate / Q000627:therapeutic use*
chemical_list: D019287:Zinc Sulfate