title: Stromal mediation of radiation carcinogenesis.
abstract: Ionizing radiation is a well-established carcinogen in human breast and rodent mammary gland. This review addresses evidence that radiation elicits the critical stromal context for cancer, affecting not only frequency but the type of cancer. Recent data from the breast tumors of women treated with radiation therapy and the cellular mechanisms evident in experimental models suggest that radiation effects on stromal-epithelial interactions and tissue composition are a major determinant of cancer development.
authors.affiliation: Departments of Radiation Oncology and Cell Biology, New York University School of Medicine, 566 First Avenue, New York, NY 10016, USA. MHBarcellos-Hoff@nyumc.org
authors.forename: Mary Helen
authors.initials: MH
authors.lastname: Barcellos-Hoff
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000209:etiology* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D017154:Stromal Cells / Q000473:pathology / Q000528:radiation effects*