title: Clinicopathologic characteristics of CD99-positive diffuse large B-cell lymphoma.
abstract: BACKGROUND
  CD99 immunoreactivity has been documented in a variety of tumors, including lymphoid malignancies such as anaplastic large-cell lymphomas. However, few studies have investigated the prognostic impact of CD99 in diffuse large B-cell lymphoma (DLBCL).
  
  
  METHODS
  Using conventional paraffin embedding, immunoperoxidase staining and tissue microarrays, we retrospectively investigated CD99 expression in 155 DLBCL patients.
  
  
  RESULTS
  Of the 155 DLBCL patients, 60 (38.7%) were positive for CD99. CD99 positivity was significantly associated with advanced stage (p < 0.01), higher risk group according to the International Prognostic Index risk score (p < 0.01) and non-germinal center B cell-like type (p = 0.01). The difference in progression-free survival (PFS) between CD99+ and CD99- groups was statistically significant (p = 0.04), even though the difference in overall survival was not (p = 0.74). Multivariate analysis demonstrated that CD99 expression was marginally correlated with PFS.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first report on the clinicopathologic characteristics of CD99+ DLBCL, particularly unique clinicopathologic features.
authors.affiliation: Department of Medicine, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.
authors.forename: Sang Pyo
authors.initials: SP
authors.lastname: Lee
authors.forename: Sanghui
authors.initials: S
authors.lastname: Park
authors.forename: Jinny
authors.initials: J
authors.lastname: Park
authors.forename: Junshik
authors.initials: J
authors.lastname: Hong
authors.forename: Young Hyeh
authors.initials: YH
authors.lastname: Ko
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D018572:Disease-Free Survival; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules