title: Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support.
abstract: A simple, efficient and environment-friendly procedure is developed for the synthesis of 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in the presence of N,N-dimethylformamide as an energy transfer medium, p-TsOH as catalyst and basic alumina as solid support under microwave irradiation. The products are obtained in moderate to good yields and are in a state of high purity. Moreover, title compounds have been screened for antifungal activity.
authors.affiliation: Department of Chemistry, University of Jammu, Jammu-180006, India. monika.gupta77@indiatimes.com
authors.forename: Monika
authors.initials: M
authors.lastname: Gupta
authors.forename: Satya
authors.initials: S
authors.lastname: Paul
authors.forename: Rajive
authors.initials: R
authors.lastname: Gupta
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects*; D001234:Aspergillus niger / Q000187:drug effects*; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D015394:Molecular Structure; D010407:Penicillium / Q000187:drug effects*; D012233:Rhizopus / Q000187:drug effects*; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C558520:4H-pyrazolo(4,5-f)(1,2,4)triazolo(4,3-b)(1,2,4)triazepine; D000935:Antifungal Agents; D001381:Azepines; D014230:Triazoles