title: Beta blockers in coronary artery disease with and without hypertension.
abstract: Beta-adrenergic blockers (BB) were developed to treat angina. Trials of BB with myocardial infarction (MI) setting were highly successful in the pre-thrombolytic era. Subsequently BB proved to be beneficial in post-thrombolytic MI in long-term use. In stable angina BB gives good symptomatic relief primarily by reducing myocardial oxygen demand. In the set-up of unstable angina/non-ST elevation MI they prevent arrhythmia and progression to ST elevation MI. BB have also been shown to retard the progression of atherosclerosis. In congestive cardiac failure (CCF) they are now the first-line drugs with ACE inhibitors to impart prognostic benefit. Their role in improving outcome of cardiac and non-cardiac surgeries has found good evidence and recommendation. But in the field where BB have scored maximally, ie, in hypertension, their role is recently debated. But the unchallenged fact remains that in presence of any form of coronary artery disease, BB are the most preferred class of drugs to treat hypertension.
authors.affiliation: Department of Cardiology, Medical College, Kolkata-700 019, West Bengal, India. guhas55@hotmail.com
authors.forename: Santanu
authors.initials: S
authors.lastname: Guha
authors.forename: Saumitra
authors.initials: S
authors.lastname: Ray
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000188:drug therapy / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D050197:Atherosclerosis / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy*; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D009203:Myocardial Infarction / Q000188:drug therapy*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents