title: [Regulation of the transcription of oxidized low-density-lipoprotein receptor by angiotensin II].
abstract: OBJECTIVE
  To observe the effects of different concentrations Angiotensin II on the transcription of LOX1 in culture human umbilical vein endothelial cells and to explore its mechanism.
  
  
  METHODS
  Reverse transcription-polymerase chain reaction (RT-PCR).
  
  
  RESULTS
  (1) Angiotensin II cause a concentration-dependent increase of the level of LOX1 mRNA. (2) Losartan, the inhibitor of AT1 receptor subtypes, inhibited this effects.
  
  
  CONCLUSIONS
  Angiotensin II stimulated the gene expression of LOX1 by activating AT1 receptor subtype in culture human endothelial cells.
authors.affiliation: Department of Cardiology, First Hospital, Beijing Medical University, Beijing 100034, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Xu
authors.forename: J H
authors.initials: JH
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Ke
authors.forename: L Y
authors.initials: LY
authors.lastname: Feng
authors.forename: T
authors.initials: T
authors.lastname: Ning
authors.forename: J
authors.initials: J
authors.lastname: Cao
authors.forename: C S
authors.initials: CS
authors.lastname: Tang
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D019808:Losartan / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics; D011945:Receptors, Angiotensin / Q000235:genetics / Q000378:metabolism*; D051127:Scavenger Receptors, Class E / Q000235:genetics / Q000378:metabolism*
chemical_list: D057911:Angiotensin Receptor Antagonists; C495137:OLR1 protein, human; D012333:RNA, Messenger; D011945:Receptors, Angiotensin; D051127:Scavenger Receptors, Class E; D000804:Angiotensin II; D019808:Losartan