title: The effect of protectants and pH changes on the cellular growth and succinic acid yield of Mannheimia succiniciproducens LPK7.
abstract: The harmful effects of succinic acid and oxidative stress on cell growth were determined during batch fermentation with Mannheimia succiniciproducens LPK7, a powerful succinic acid-producing strain, and conditions were optimized to minimize these effects. In terms of toxicity, the cell concentration decreased as the concentration of succinic acid increased. By changing the pH from 6.5 to 7 during fermentation, the cell concentration increased by about 10%, and the level of succinic acid production was 6% higher than that of the control. In addition, by introducing protectants, the cell concentration increased by about 10%, and the level of succinic acid produced was increased by 3%.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 121-742, Republic of Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Oh
authors.forename: In Jae
authors.initials: IJ
authors.lastname: Oh
authors.forename: Changkyou
authors.initials: C
authors.lastname: Jung
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lee
authors.forename: Jinwon
authors.initials: J
authors.lastname: Lee
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D031121:Mannheimia / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism*; D018384:Oxidative Stress; D019802:Succinic Acid / Q000378:metabolism* / Q000633:toxicity*; D014199:Trehalose / Q000378:metabolism
chemical_list: D000975:Antioxidants; D019802:Succinic Acid; D014199:Trehalose; D005978:Glutathione