title: The effects of pargyline and 2-phenylethylamine on D1-like dopamine receptor binding.
abstract: 2-Phenylethylamine (PE) potentiates neuronal responses to dopamine by an unknown post-synaptic mechanism. Here, whether PE modifies D1-like receptor binding was examined. An unexpected effect of the monoamine oxidase inhibitor pargyline was observed, which did not involve competition for ligand binding. PE did not affect ligand binding in the presence or absence of pargyline. It is concluded that the effect of pargyline does not involve elevation of endogenous PE, and PE effects on dopaminergic neurotransmission are not due to altered D1-like receptor binding.
authors.affiliation: Department of Chemistry, Brandon University, Brandon, MB, R7A 6A9, Canada. berrym@brandonu.ca
authors.forename: Mark D
authors.initials: MD
authors.lastname: Berry
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*; D011485:Protein Binding / Q000502:physiology; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000378:metabolism*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D017447:Receptors, Dopamine D1; C029261:phenethylamine; D010293:Pargyline