title: Sublancin is not a lantibiotic but an S-linked glycopeptide.
abstract: Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a cysteine residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase was reconstituted in vitro, and the enzyme is shown to have relaxed substrate specificity, allowing the preparation of analogs of sublancin. Glycosylation is essential for its antimicrobial activity.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
authors.forename: Trent J
authors.initials: TJ
authors.lastname: Oman
authors.forename: John M
authors.initials: JM
authors.lastname: Boettcher
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Xenia N
authors.initials: XN
authors.lastname: Okalibe
authors.forename: Wilfred A
authors.initials: WA
authors.lastname: van der Donk
mesh_terms: D001430:Bacteriocins / Q000494:pharmacology*; D006020:Glycopeptides / Q000494:pharmacology*; D053719:Tandem Mass Spectrometry
chemical_list: D001430:Bacteriocins; D006020:Glycopeptides