title: Concurrent breast stroma sarcoma and breast carcinoma: a case report.
abstract: BACKGROUND
  Breast cancer is one of the most important health problems in the world and affects a great number of women over the entire globe. This group of tumors rarely presents as bilateral disease and, when it does happen, normally occurs within the same histological type. We report a rare case of concurrent bilateral breast cancer with two different histology types, a breast carcinoma and a breast sarcoma, in a 42-year-old woman referred to our hospital.
  
  
  METHODS
  A 42-year-old Caucasian woman admitted to our institute in August 1999, presented with a nodule in the left breast of 3.0 × 2.5 cm, and, in the right breast, one of 1.0 cm, suspected of malignancy and with a clinically negative armpit. Biopsies had revealed invasive mammary carcinoma (right breast) and sarcoma (left breast). She was submitted to bilateral modified radical mastectomy. A histological study showed an invasive mammary carcinoma degree II lobular pleomorphic type with invasion of seven of the 19 excised axillary nodes in the right breast and, in the left breast, a sarcoma of the mammary stroma, for which the immunohistochemistry study was negative for epithelial biomarkers and positive for vimentin. Later, she was submitted for chemotherapy (six cycles of 75 mg/m2 5-fluorouracil, epirubicin and cyclophosphamide) followed by radiotherapy of the thoracic wall and axillary nodes on the left. Hormone receptors were positive in the tumor of the right breast, and tamoxifen, 20 mg, was prescribed on a daily basis (five years) followed by letrozole, 2.5 mg, also daily (five years). She presented no sign of negative evolution in the last consultation.
  
  
  CONCLUSIONS
  The risk of development of bilateral breast cancer is about 1% each year within a similar histological type, but it is higher in tumors with lobular histology. In this case, the patient presented, simultaneously, two histologically distinct tumors, thus evidencing a rare situation.
authors.affiliation: Department of Medical Oncology, Instituto Português de Oncologia de Coimbra, Francisco Gentil, Avenida Bissaya Barreto, 98, 3000-075, Coimbra, Portugal. ramondemello@gmail.com.
authors.forename: Ramon Andrade
authors.initials: RA
authors.lastname: de Mello
authors.forename: Paulo
authors.initials: P
authors.lastname: Figueiredo
authors.forename: Mariela
authors.initials: M
authors.lastname: Marques
authors.forename: Gabriela
authors.initials: G
authors.lastname: Sousa
authors.forename: Teresa
authors.initials: T
authors.lastname: Carvalho
authors.forename: Helena
authors.initials: H
authors.lastname: Gervásio