title: Global Osteitis Scoring Scale and chronic rhinosinusitis: a marker of revision surgery.
abstract: OBJECTIVE
  Determine the incidence and severity of osteitis in patients with chronic rhinosinusitis using a new Global Osteitis Scoring Scale.
  
  
  METHODS
  Validation and prospective case-control study.
  
  
  METHODS
  Academic Tertiary Otolaryngology Department (Academic Medical Centre, Amsterdam).
  
  
  METHODS
  A prospective series of 102 patients undergoing a computed tomography (CT) sinuses as part of their evaluation for chronic rhinosinusitis between January and May 2008 (study group) and an age- and gender-matched control group of 68 non-rhinosinusitis patients. Seventy-eight of the chronic rhinosinusitis patients completed the nasal subset of the RhinoSinusitis Outcome Measure (RSOM-31) and visual analogue scales. Their CT scans were assessed for osteitis using a newly developed Global Osteitis Scoring Scale. A subsample of 35 scans were additionally scored by a second otolaryngologist and a radiologist.
  
  
  METHODS
  Global Osteitis Scoring Scale.
  
  
  RESULTS
  The interrater variability of Global Osteitis Scoring Scale was low (average intraclass correlation coefficient: 0.94). Forty per cent of the chronic rhinosinusitis group and none of the control group had evidence of clinically significant osteitis. In the chronic rhinosinusitis group (102 patients), the severity of osteitis was correlated with Lund-Mackay (L-M) score (P<0.001), duration of symptoms (P<0.01) and previous surgery (P<0.001), rising in incidence with increasing number of previous operations. There was no association between osteitis and age, gender, smoking, co-existing asthma, allergy or Sumpter's triad. Additionally, there was no correlation between osteitis and symptom burden including headache, facial pain and nasal subset score of the RhinoSinusitis Outcome Measure.
  
  
  CONCLUSIONS
  In patients with recalcitrant chronic rhinosinusitis who have undergone multiple surgeries in the past, the incidence of osteitis can be as high as 64%. It does not seem to be associated with more troublesome symptoms; however, it is strongly associated with previous sinus surgery, which may be a manifestation of a shared endpoint (underlying recalcitrant disease).
authors.affiliation: Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands. cgeorgalas1@yahoo.co.uk
authors.forename: C
authors.initials: C
authors.lastname: Georgalas
authors.forename: W
authors.initials: W
authors.lastname: Videler
authors.forename: N
authors.initials: N
authors.lastname: Freling
authors.forename: W
authors.initials: W
authors.lastname: Fokkens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000000981:diagnostic imaging* / Q000601:surgery; D011446:Prospective Studies; D012220:Rhinitis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D012720:Severity of Illness Index; D012852:Sinusitis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult