title: Effect of zoledronic acid used in the root surface treatment of late replanted teeth: a study in rats.
abstract: This study evaluated the use of zoledronic acid, a resorption inhibitor, as a medication for root resorption treatment of late replanted teeth. Twenty-four maxillary right central incisors of rats were avulsed and kept dry for 30 min. Then, the teeth were divided into 2 groups. In group I, root surface was treated with 2% sodium fluoride for 20 min; in group II, 10-6M zoledronic acid solution was used for 20 min. All root canals were filled with calcium hydroxide. Next, teeth were replanted in their respective sockets. After 15 and 60 days post-replantation, the animals were killed and the anatomic pieces were obtained and prepared for microscopic and morphometric analyses. The results showed that zoledronic acid was capable of limiting the occurrence of root resorption and preserving cementum resorption. Further research must be performed to confirm the use of zoledronic acid in root surface treatment of late replanted teeth.
authors.affiliation: Integrated Clinic Area, Araçatuba Dental School, São Paulo State University, Araçatuba, SP, Brazil. grazielagm@hotmail.com
authors.forename: Graziela Garrido
authors.initials: GG
authors.lastname: Mori
authors.forename: Daniela Maria de Mendonça
authors.initials: DM
authors.lastname: Janjacomo
authors.forename: Daniele Clapes
authors.initials: DC
authors.lastname: Nunes
authors.forename: Lithiene Ribeiro
authors.initials: LR
authors.lastname: Castilho
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003238:Connective Tissue / Q000187:drug effects; D003739:Dental Cementum / Q000187:drug effects; D004164:Diphosphonates / Q000627:therapeutic use*; D007091:Image Processing, Computer-Assisted; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D012389:Root Canal Obturation / Q000379:methods; D018915:Root Canal Preparation / Q000379:methods; D012391:Root Resorption / Q000188:drug therapy; D012969:Sodium Fluoride / Q000627:therapeutic use; D013997:Time Factors; D020254:Tooth Ankylosis / Q000209:etiology; D014084:Tooth Avulsion / Q000628:therapy; D014090:Tooth Replantation / Q000379:methods*; D014092:Tooth Root / Q000187:drug effects*; D020390:Tooth Socket / Q000601:surgery; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D012387:Root Canal Filling Materials; D000077211:Zoledronic Acid; D012969:Sodium Fluoride; D002126:Calcium Hydroxide