title: Assessment of experimental saccular aneurysm using selective angiography in common carotid artery of rabbits.
abstract: In order to study the treatment of aneurysms, the technique of making experimental aneurysms in laboratory animals must be established. In our study, to examine the feasibility of making experimental aneurysm and selective angiography on the common carotid artery in rabbits and to determine the size of experimental aneurysm after surgery, saccular aneurysms were fashioned on the right common carotid artery in 17 rabbits using a vein pouch technique. Selective angiography of the common carotid artery was performed immediately after surgery, and at 1 week, 4 weeks, and 8 weeks after surgery. Also, histological changes in the aneurysms were observed. In 16 rabbits with established successful experimental aneurysm, no differences were found in diet intake and behavior before and after surgery. The patency of the carotid artery was confirmed by selective angiography. The average size of the aneurysm immediately after surgery was similar to that of 1 week postoperatively in selective angiography, however it increased with time at 4weeks and 8 weeks. Histologically, infiltration of inflammatory cells and hemorrhage were found at the junction of the carotid artery and the vein pouch at 1 week, which disappeared at 4 weeks and 8 weeks. This study suggests experimental saccular aneurysm using the vein pouch technique might form aneurysms similar to that of the human in its properties such as increment of size, and selective angiography might be suitable for assessment of experimental aneurysm. Therefore, this animal model may be suitable for investigating new treatment methodologies for human aneurysms.
authors.affiliation: Department of Veterinary Radiology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
authors.forename: Dong Woo
authors.initials: DW
authors.lastname: Chang
authors.forename: Bong Kyung
authors.initials: BK
authors.lastname: Kim
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Shin
authors.forename: Young Min
authors.initials: YM
authors.lastname: Yoon
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Oh
authors.forename: Yeo Sung
authors.initials: YS
authors.lastname: Yoon
authors.forename: Sung-Hyeok
authors.initials: SH
authors.lastname: Hong
authors.forename: Ki Chang
authors.initials: KC
authors.lastname: Lee
authors.forename: Young Won
authors.initials: YW
authors.lastname: Lee
authors.forename: Kang Moon
authors.initials: KM
authors.lastname: Seo
authors.forename: Oh-Kyeong
authors.initials: OK
authors.lastname: Kweon
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Yoon
authors.forename: Nam-Shik
authors.initials: NS
authors.lastname: Shin
authors.forename: Kyu Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Jun-Gyo
authors.initials: JG
authors.lastname: Suh
authors.forename: Je Kyung
authors.initials: JK
authors.lastname: Seong