title: [Effect of losartan on arterial blood pressure and unit discharging of neurons in LHb and MHb of rat].
abstract: OBJECTIVE
  To investigate the effect of 2 mg/kg and 10 mg/kg losartan intraperitoneally (i.p) on arterial blood pressure (AP) and heart rate (HR) in rat and the involvement in the activity of habenulas neurons. Glass micropipette was used to record any changes of unit discharging of neurons in LHb and MHb before and after losartan was intraperitoneally injected.
  
  
  RESULTS
  AP and HR were not significantly changed by 2 mg/kg losartan (i.p). However, AP was apparently decreased by 10 mg/kg losartan (i.p), but HR was unchanged. After 10 mg/kg losartan (i.p), 66.66% (12/18) unit discharging of neurons in LHb were increased in frequency, and 61.90% (13/21) in MHb were decreased.
  
  
  CONCLUSIONS
  AP of rat was significantly decreased by 10 mg/kg losartan (i.p). Depressor effect of losartan (i.p) was involved in the excision of neurons in LHb and the inhibition in MHb.
authors.affiliation: Department of Physiology, The School of Basic Medical Sciences, Norman Bethune University of Medical Sciences, Jilin Changchun 130021, China.
authors.forename: Yu-Zhen
authors.initials: YZ
authors.lastname: Pan
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Wang
authors.forename: Shui-Sheng
authors.initials: SS
authors.lastname: Wu
authors.forename: Shao
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D019262:Habenula / Q000187:drug effects / Q000502:physiology*; D019808:Losartan / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019808:Losartan