title: Synthesis, characterization luminiscence studies and microbial activity of ethylenediamine ruthenium (II) complexes with dipyridophenazine ligands.
abstract: Three symmetric ligands 7-methyl dipyrido-[3,2-a;2',3'-c]phenazine (dppz-CH(3)), 7-nitro dipyrido-[3,2-a;2',3'-c]phenazine (dppz-NO(2)) and benzo[i]dipyrido-[3,2-a;2',3'-c]phenazine (dppn) and their ruthenium(II) complexes [Ru(en)(2)(L)][ClO(4)](2) (en= ethylenediamine), L= dppz-CH(3), dppz-NO(2) and dppn have been synthesized and characterized by IR, (1)H, (13)C NMR and Mass spectra. The interactions of these complexes with calf thymus DNA have been investigated by spectrophotometric, spectrofluorimetric, circular dichroism, viscosity and thermal denaturation studies. As the planar extension of the intercalative ligand increases, the interaction of the complex with DNA increases, indicating that the size and shape of the intercalalative ligand has a marked effect on the strength of interaction. The plot of log K versus log [Na(+)] yield a slope of -1.26, -1.53, -1.60 for the complexes 1, 2 and 3 respectively. These three complexes have been found to promote the cleavage of plasmid pBR 322 DNA upon irradiation.
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh, India PIN-500007.
authors.forename: Mynam
authors.initials: M
authors.lastname: Shilpa
authors.forename: Penumaka
authors.initials: P
authors.lastname: Nagababu
authors.forename: Y Praveen
authors.initials: YP
authors.lastname: Kumar
authors.forename: J Naveena Lavanya
authors.initials: JN
authors.lastname: Latha
authors.forename: M Rajender
authors.initials: MR
authors.lastname: Reddy
authors.forename: K S
authors.initials: KS
authors.lastname: Karthikeyan
authors.forename: Nazar Md
authors.initials: NM
authors.lastname: Gabra
authors.forename: Sirasani
authors.initials: S
authors.lastname: Satyanarayana
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D004247:DNA / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D005029:Ethylenediamines / Q000737:chemistry; D008024:Ligands; D008163:Luminescent Measurements; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D010619:Phenazines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D005029:Ethylenediamines; D008024:Ligands; D009942:Organometallic Compounds; D010619:Phenazines; C031234:ethylenediamine; D012428:Ruthenium; D004247:DNA; C427203:calf thymus DNA