title: Enhancing cell recognition by scrutinizing cell surfaces with a nanoparticle array.
abstract: We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.
authors.affiliation: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Peifu
authors.initials: P
authors.lastname: Jiao
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D001692:Biological Transport; D045744:Cell Line, Tumor; D058973:Folate Receptors, GPI-Anchored / Q000378:metabolism; D005492:Folic Acid / Q000378:metabolism; D005786:Gene Expression Regulation; D006046:Gold / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D053768:Metal Nanoparticles; D036103:Nanotechnology / Q000295:instrumentation*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D058973:Folate Receptors, GPI-Anchored; D008024:Ligands; D011956:Receptors, Cell Surface; D006046:Gold; D005492:Folic Acid