title: Nucleosome structural studies.
abstract: Chromatin plays a fundamental role in eukaryotic genomic regulation, and the increasing awareness of the importance of epigenetic processes in human health and disease emphasizes the need for understanding the structure and function of the nucleosome. Recent advances in chromatin structural studies, including the first structures of nucleosomes containing the Widom 601 sequence and the structure of a chromatin protein-nucleosome assembly, have provided new insight into stretching of nucleosomal DNA, nucleosome positioning, binding of metal ions, drugs and therapeutic candidates to nucleosomes, and nucleosome recognition by nuclear proteins. These discoveries ensure promising future prospects for unravelling structural attributes of chromatin.
authors.affiliation: Center for Eukaryotic Gene Regulation, Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Song
authors.initials: S
authors.lastname: Tan
authors.forename: Curt A
authors.initials: CA
authors.lastname: Davey
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D009707:Nucleosomes / Q000737:chemistry*; D011485:Protein Binding
chemical_list: D009687:Nuclear Proteins; D009707:Nucleosomes; D004247:DNA