title: Am I my brother's keeper?: fratricide in the kidney.
abstract: Experimental acute kidney injury (AKI) is accompanied by the death of renal tubule epithelial cells, necrosis and apoptosis of the terminal portion of the proximal tubule, and apoptosis in the distal nephron. While immune competent cells invading the kidney play a role in such cell death, intervention in these processes only partially ameliorates the extent of cell death. Given the results of Linkermann et al. in this issue of KI, an epithelium-derived component of immune mediated cell death must now be strongly considered.
authors.affiliation: Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. SafirsteinRobertL@uams.edu
authors.forename: Robert L
authors.initials: RL
authors.lastname: Safirstein
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D000818:Animals; D017209:Apoptosis; D002945:Cisplatin / Q000633:toxicity; D004847:Epithelial Cells / Q000276:immunology / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000276:immunology / Q000473:pathology; D051379:Mice; D009336:Necrosis
chemical_list: D002945:Cisplatin