title: Preliminary data on endoscopic treatment of vesicoureteric reflux with polyacrylate polyalcohol copolymer (Vantris®): surgical outcome following single injection.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of single injection of a new non-biodegradable agent (Vantris(®)) Manufactured by Promedon, Cordoba, Argentina for treatment of vesicoureteric reflux (VUR).
  
  
  METHODS
  38 children (11 males and 27 females) with a mean age of 5.3 ± 3.8 years underwent endoscopic treatment of VUR using Vantris. VUR was unilateral in 17 and bilateral in 21 patients, comprising 59 renal refluxing units (RRU). The VUR was primary in 42 RRU and 17 comprised complex cases: 3 duplex systems, 1 with prune belly syndrome, and 13 after failed previous endoscopic correction with Deflux(®). VUR was Grade I in 5, II in 11, III in 23, IV in 15 and V in 5 RRU.
  
  
  RESULTS
  All patients completed 3 months of follow up. The reflux was corrected in 56 (94.9%) of the 59 RRU (35/38 patients) after a single injection. Of the 38 patients, 21 completed 1 year of follow up, at which time ultrasound demonstrated no change compared with 1 month after injection. Eight of these 21 children underwent 1 year radionuclide cystography, and no reflux recurrence was shown.
  
  
  CONCLUSIONS
  Our short-term data show that Vantris injection provides a high level of reflux resolution. Long-term follow up with this tissue-augmenting substance is required.
authors.affiliation: Department of Pediatric Urology, Shaare Zedek Medical Center, Faculty of Medical Science, Hebrew University, P.O. Box 3235, 91031 Jerusalem, Israel. boris.chertin@gmail.com
authors.forename: Boris
authors.initials: B
authors.lastname: Chertin
authors.forename: Wael Abu
authors.initials: WA
authors.lastname: Arafeh
authors.forename: Alexander
authors.initials: A
authors.lastname: Zeldin
authors.forename: Stanislav
authors.initials: S
authors.lastname: Kocherov
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage*; D000293:Adolescent; D001672:Biocompatible Materials / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004724:Endoscopy; D005260:Female; D006801:Humans; D007223:Infant; D007267:Injections; D008297:Male; D019736:Prostheses and Implants; D014718:Vesico-Ureteral Reflux / Q000628:therapy*
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; C530415:Vantris