title: Role of dendritic cells: a step forward for the hygiene hypothesis.
abstract: The hygiene hypothesis was proposed more than two decades ago, but its mechanism remains unclear. This review focuses on recent advances in the field, especially on the role played by dendritic cells (DCs) and their modulating effects on various infections and allergic diseases, including allergic asthma. DCs isolated from mice long after the resolution of an infection were reported to have a significant modulating effect on allergen-specific Th2 responses in both in vitro and in vivo systems. These DCs showed DC1-like and/or tolerogenic DC capacity, which allowed for the inhibition of allergic responses by immune deviation (enhancing Th1 response) and immune regulation (through regulatory T-cell and Th2 hyporesponsiveness) mechanisms. These findings represented a significant advance in the elucidation of the mechanisms underlying the hygiene hypothesis. Further investigation on the mechanisms by which DCs are 'educated' by infectious agents and the influence of the type, time, and extent of infections on this 'education' process will help us understand immune regulation in disease settings and in the rational design of preventive/therapeutic approaches to allergy/asthma and infections.
authors.affiliation: Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada. yangxi@cc.umanitoba.ca
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Gao
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006920:Hygiene; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology; D055633:Immune System Phenomena / Q000502:physiology; D007108:Immune Tolerance / Q000502:physiology; D007109:Immunity / Q000502:physiology; D007239:Infections / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D058408:Th1-Th2 Balance; D018418:Th2 Cells / Q000276:immunology; D013997:Time Factors
chemical_list: D000485:Allergens