title: Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold.
abstract: Previously the synthesis of novel somatostatin mimetic from 1-deoxynojirimycin (DNJ) led to identification of a compound with affinity for human somatostatin receptor subtypes 4 and 5 (hSSTR4 and hSSTR5). Here we examined the properties of this peptidomimetic in a human umbilical vein endothelial cell (HUVEC) based assays. The peptidomimetic prevented capillary tube formation based on HUVECs. It also inhibited HUVEC proliferation by inducing G1 phase cell cycle arrest and apoptosis. Stress fiber assembly and cell migration in HUVECs was markedly suppressed by the somatostatin receptor ligand.
authors.affiliation: Department of Pharmacology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors.forename: Yunxue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Vincent
authors.initials: V
authors.lastname: Chagnault
authors.forename: Juying
authors.initials: J
authors.lastname: Wang
authors.forename: Xiumei
authors.initials: X
authors.lastname: Zhang
authors.forename: Paul V
authors.initials: PV
authors.lastname: Murphy
mesh_terms: D017485:1-Deoxynojirimycin / Q000737:chemistry / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D013004:Somatostatin / Q000737:chemistry / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology
chemical_list: D017485:1-Deoxynojirimycin; D013004:Somatostatin