title: Protective effect of embelin against acetic acid induced ulcerative colitis in rats.
abstract: The aim of the present study is to evaluate the effect of embelin isolated from Embelia ribes on acetic acid induced colitis in rats. Experimental animals received embelin (25 and 50 mg/kg, p.o.) and sulfasalazine (100mg/kg, p.o.) for five consecutive days before induction of colitis by intra-rectal acetic acid (3% v/v) administration and the treatment continued up to 7 days. The colonic mucosal injury was assessed by clinical, macroscopic, biochemical and histopathological examinations. Embelin treatment significantly decreased clinical activity score, gross lesion score, percent affected area and wet colon weight when compared to acetic acid induced controls. The treatment also reduced significantly the colonic myeloperoxidase activity, lipid peroxides and serum lactate dehydrogenase and significantly increased the reduced glutathione. The histopathological studies also confirmed the foregoing findings. The protective effect may be due to its antioxidant and anti-inflammatory activities.
authors.affiliation: Sree Siddaganga College of Pharmacy, Tumkur, KN, India. t_swamy@hotmail.com
authors.forename: Boreddy Shivanandappa
authors.initials: BS
authors.lastname: Thippeswamy
authors.forename: Sekar
authors.initials: S
authors.lastname: Mahendran
authors.forename: Mahantesh I
authors.initials: MI
authors.lastname: Biradar
authors.forename: Pooja
authors.initials: P
authors.lastname: Raj
authors.forename: Kamya
authors.initials: K
authors.lastname: Srivastava
authors.forename: Shrishailappa
authors.initials: S
authors.lastname: Badami
authors.forename: Veeresh Prabhakar
authors.initials: VP
authors.lastname: Veerapur
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D016227:Benzoquinones / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D031645:Embelia / Q000737:chemistry; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012460:Sulfasalazine / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016227:Benzoquinones; D005765:Gastrointestinal Agents; D012460:Sulfasalazine; D019342:Acetic Acid; C010945:embelin