title: Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury.
abstract: Microglial activation is one of the causative factors of neuroinflammation in cerebral ischemia. Activation via Toll-like receptors (TLRs) causes increased proinflammatory cytokine expression, such as interleukin-23 (IL-23) and interleukin-17 (IL-17), leading to inflammatory immune responses and neuronal damage. In this study, using a rat focal cerebral ischemia reperfusion (IR) model and an in vitro oxygen-glucose deprivation reperfusion (OGDR) system, we found that TLR2, IL-23 and IL-17 form an axis that leads to increased neuronal apoptosis. TLR2 activation results in IL-23 production which stimulates IL-17 production by microglia. This microglial axis may be a potential therapeutic target to control neuroinflammation in brain IR.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, PR China.
authors.forename: M
authors.initials: M
authors.lastname: Lv
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Su
authors.forename: Z
authors.initials: Z
authors.lastname: Su
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015153:Blotting, Western; D002545:Brain Ischemia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D007249:Inflammation / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D020381:Interleukin-17 / Q000378:metabolism*; D053759:Interleukin-23 / Q000378:metabolism*; D008297:Male; D017628:Microglia / Q000276:immunology / Q000378:metabolism*; D009474:Neurons / Q000473:pathology; D034741:RNA, Small Interfering; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology; D051195:Toll-Like Receptor 2 / Q000378:metabolism*; D014162:Transfection
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23; D034741:RNA, Small Interfering; C495343:Tlr2 protein, rat; D051195:Toll-Like Receptor 2