title: Association of anti-glomerular basement membrane antibody disease with dermatomyositis and psoriasis: case report.
abstract: BACKGROUND
  anti-glomerular basement membrane (anti-GBM) antibody syndrome is characterized by deposition of anti-GBM antibodies on affected tissues, associated with glomerulonephritis and/or pulmonary involvement. This syndrome has been described in association with other autoimmune disorders, but as far as we know, it has not been described in association with dermatomyositis and psoriasis.
  
  
  METHODS
  a 51-year-old man with a history of dermatomyositis and vulgar psoriasis presented with a condition of sensitive-motor polyneuropathy of the hands and feet, weight loss of 4 kg, malaise and fever. On admission, he had been making chronic use of cyclosporin and antihypertensive drugs for three months because of mild arterial hypertension. Laboratory tests showed anemia and leukocytosis, elevated serum urea and creatinine and urine presenting proteinuria, hematuria, leukocyturia and granular casts. The 24-hour proteinuria was 2.3 g. Renal biopsy showed crescentic necrotizing glomerulonephritis with linear immunoglobulin G (IgG) deposits on the glomerular basement membrane by means of direct immunofluorescence, which were suggestive of anti-GBM antibodies. The patient was then treated initially with methylprednisolone and with monthly cyclophosphamide in the form of pulse therapy.
authors.affiliation: Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Natália Pereira
authors.initials: NP
authors.lastname: Machado
authors.forename: Cintia Zumstein
authors.initials: CZ
authors.lastname: Camargo
authors.forename: Ana Cecília Diniz
authors.initials: AC
authors.lastname: Oliveira
authors.forename: Ana Letícia Pirozzi
authors.initials: AL
authors.lastname: Buosi
authors.forename: Mário Luiz Cardoso
authors.initials: ML
authors.lastname: Pucinelli
authors.forename: Alexandre Wagner Silva de
authors.initials: AW
authors.lastname: Souza
mesh_terms: D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D003882:Dermatomyositis / Q000150:complications / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic