title: [Experience in the management of pediatric patients with Gaucher disease].
abstract: Among lysosomal storage diseases, Gaucher disease depicts the highest rate of incidence, according with the international epidemiological reports. Gaucher disease is due to an impairing of the acid beta-glucosidase enzyme, since its lack promotes accumulation of the sphingolipid glucosylceramide at macrophages, leading to heterogeneous multiorganic damage (visceral, skeletal, and central nervous system affectation). This paper portrays a series of clinical cases of Gaucher disease with patients treated at the same city (Monterrey, Nuevo León), at the Paediatric Haematology Department of the Specialties General Hospital, UMAE 25, in Monterrey of the Instituto Mexicano del Seguro Social. Gaucher disease is symptomatic since early childhood in a good proportion of patients. The patients in this serie was treated with enzyme replacement therapy, and share the typical overall features of the disease.
authors.affiliation: Departamento de Hematología Pediátrica, Hospital de Especialidades 25, Instituto Mexicano del Seguro Social, Monterrey, Nuevo León, México. terepompa@yahoo.com.mx
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Pompa-Garza
authors.forename: María Guadalupe
authors.initials: MG
authors.lastname: González-Villarreal
authors.forename: José Luis
authors.initials: JL
authors.lastname: Cedillo-de la Cerda
mesh_terms: D002675:Child, Preschool; D005260:Female; D005776:Gaucher Disease / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D055815:Young Adult