title: Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir.
abstract: We studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and T97A-N155H. Thus, despite a 40% difference in integrase genes between HIV-1 and HIV-2, the genetic pathways leading to raltegravir resistance are similar.
authors.affiliation: Hôpital Bichat-Claude Bernard, Laboratoire de Virologie, 46 Rue Henri Huchard, 75018 Paris, France. charlotte.charpentier@bch.aphp.fr
authors.forename: Charlotte
authors.initials: C
authors.lastname: Charpentier
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Roquebert
authors.forename: Olivier
authors.initials: O
authors.lastname: Delelis
authors.forename: Lucile
authors.initials: L
authors.lastname: Larrouy
authors.forename: Sophie
authors.initials: S
authors.lastname: Matheron
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Marina
authors.initials: M
authors.lastname: Karmochkine
authors.forename: Xavier
authors.initials: X
authors.lastname: Duval
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chêne
authors.forename: Alexandre
authors.initials: A
authors.lastname: Storto
authors.forename: Gilles
authors.initials: G
authors.lastname: Collin
authors.forename: Antoine
authors.initials: A
authors.lastname: Bénard
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mouscadet
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics; D019427:HIV Integrase / Q000235:genetics*; D015498:HIV-2 / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D008969:Molecular Sequence Data; D011760:Pyrrolidinones / Q000627:therapeutic use*; D000068898:Raltegravir Potassium
chemical_list: D000998:Antiviral Agents; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D019427:HIV Integrase