title: TMEM16A protein: a new identity for Ca(2+)-dependent Cl⁻ channels.
abstract: Ca(+)-dependent Cl⁻ channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl⁻ secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.
authors.affiliation: Laboratory of Molecular Genetics, Istituto Giannina Gaslini, Genova, Italy.
authors.forename: Loretta
authors.initials: L
authors.lastname: Ferrera
authors.forename: Antonella
authors.initials: A
authors.lastname: Caputo
authors.forename: Luis J V
authors.initials: LJ
authors.lastname: Galietta
mesh_terms: D000818:Animals; D000075369:Anoctamin-1; D018118:Chloride Channels / Q000737:chemistry / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011487:Protein Conformation; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: C476213:ANO1 protein, human; C531181:ANO1 protein, mouse; C552942:ANO1 protein, rat; D000075369:Anoctamin-1; D018118:Chloride Channels; D002712:Chlorides; D008565:Membrane Proteins; D009363:Neoplasm Proteins