title: Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic.
abstract: Lurasidone is a second-generation antipsychotic newly approved by the U.S. Food and Drug Administration for the treatment of schizophrenia. Similar to most other second-generation antipsychotics, lurasidone is a full antagonist at dopamine D2 and serotonin 5HT2A receptors. Efficacy within the dose range of 40-120 mg/d was established in four 6-week, randomized, controlled trials. The recommended starting dose is 40 mg/d and the maximum recommended dose is 80 mg/d. Doses above 80 mg/d do not appear to confer added benefit and may be associated with a dose-related increase in certain adverse reactions such as somnolence and akathisia. Lurasidone is administered once daily with at least 350 calories of food in order to optimize bioavailability. Lurasidone is primarily metabolized in the liver through the CYP3A4 enzyme system, and coadministration with drugs that are strong inhibitors of CYP3A4 (such as ketoconazole) or strong inducers (such as rifampin) are contraindicated. Lurasidone is associated with minimal weight gain and no clinically meaningful alterations in glucose, lipids, or the ECG QT interval.
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY, USA. nntman@gmail.com
authors.forename: Leslie
authors.initials: L
authors.lastname: Citrome
mesh_terms: D017109:Akathisia, Drug-Induced / Q000209:etiology; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced; D065127:Dopamine D2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D006801:Humans; D054833:Isoindoles / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D000069056:Lurasidone Hydrochloride; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy*; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D013844:Thiazoles / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D016896:Treatment Outcome; D014481:United States; D014486:United States Food and Drug Administration; D015430:Weight Gain / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D065127:Dopamine D2 Receptor Antagonists; D054833:Isoindoles; D058830:Serotonin 5-HT2 Receptor Antagonists; D013844:Thiazoles; D000069056:Lurasidone Hydrochloride