title: Antibody-mediated (immune) transfusion-related acute lung injury.
abstract: Antibody-mediated transfusion-related acute lung injury (immune TRALI) is now recognized as the most common cause of transfusion-associated major morbidity and death in the Western world. Among the implicated leucocyte antibodies, these ones directed against the human leucocyte antigens (HLA) class II, human neutrophil alloantigens (HNA)-3a and HLA-A2 antigens are frequently associated with severe (artificial ventilation required) and fatal cases. There is accumulating evidence that preventive measures such as transfusion of plasma-rich blood components from male donors or from donors tested negative for leucocyte antibodies are effective in the reduction of severe and fatal immune TRALI.
authors.affiliation: German Red Cross Blood Service West, Hagen, Germany. j.bux@bsdwest.de
authors.forename: J
authors.initials: J
authors.lastname: Bux
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology; D007519:Isoantigens; D007962:Leukocytes / Q000276:immunology; D008297:Male; D018448:Models, Immunological; D009504:Neutrophils / Q000276:immunology; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies; D007519:Isoantigens