title: Dendrimer modified graphite sensors for detection of anticancer drug Daunorubicin by voltammetry and electrochemical impedance spectroscopy.
abstract: The development of amino-terminated G4 PAMAM dendrimer (PDR) modified disposable electrodes were developed as the first time in our study by using the dendrimer modified disposable graphite (PDR-PGE) and multiwalled carbon nanotube based screen-printed graphite (PDR-MWCNT-SPE) electrodes. Firstly, the microscopic characterization of bare PGEs and PDR modified PGEs was performed. These sensors were then applied for electrochemical monitoring of an anticancer drug, Daunorubicin (DNR). The enhanced oxidation signal of DNR was measured at +0.50 V by using differential pulse voltammetry (DPV) in combination with the PDR-PGEs. The detection limit, estimated from S/N = 3, corresponds accordingly to 317 nM and 128 nM for DNR respectively at the PGE and PDR-PGE. The voltammetric results were consistent with electrochemical impedance spectroscopy (EIS) that was used to characterize the successful modification of PDR onto the surface of PGE and MWCNT-SPE.
authors.affiliation: Ege University, Faculty of Pharmacy, Analytical Chemistry Department, Bornova, 35100 Izmir, Turkey. arzum.erdem@ege.edu.tr
authors.forename: Arzum
authors.initials: A
authors.lastname: Erdem
authors.forename: Hakan
authors.initials: H
authors.lastname: Karadeniz
authors.forename: Ayfer
authors.initials: A
authors.lastname: Caliskan
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D003630:Daunorubicin / Q000032:analysis*; D050091:Dendrimers / Q000737:chemistry*; D058266:Dielectric Spectroscopy / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D011199:Potentiometry / Q000295:instrumentation / Q000379:methods*
chemical_list: D000903:Antibiotics, Antineoplastic; D050091:Dendrimers; D037742:Nanotubes, Carbon; D006108:Graphite; D003630:Daunorubicin