title: Evolutionary dynamics of rabies viruses highlights the importance of China rabies transmission in Asia.
abstract: Rabies in Asia is emerging as a serious public health issue. To explore the possible origin, phylogenetic relationships, and evolutionary dynamics of Asian Rabies viruses (RABV), we examined 200 complete nucleoprotein (N) gene sequences from RABV isolates in the region. Phylogeny supported the classification of Asian RABVs into five distinct clusters in lyssavirus genotype 1. Our geospatial and temporal analyses demonstrated that China appears to be the prime source of Asian RABVs. Understanding of rabies transmission and associated human activities, such as dog translocation, can help rabies control and elimination in Asia through collaborative efforts or programs.
authors.affiliation: Wuhan Institute of Biological Products, Wuhan, 430060, China. msl3459@yahoo.com.cn
authors.forename: Shengli
authors.initials: S
authors.lastname: Meng
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Xianfu
authors.initials: X
authors.lastname: Wu
authors.forename: Jianrong
authors.initials: J
authors.lastname: Tang
authors.forename: Gelin
authors.initials: G
authors.lastname: Xu
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Lei
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Yan
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yang
authors.forename: Charles E
authors.initials: CE
authors.lastname: Rupprecht
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D021821:Communicable Diseases, Emerging / Q000453:epidemiology; D004285:Dogs; D019143:Evolution, Molecular; D005843:Geography; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins / Q000235:genetics; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011818:Rabies / Q000453:epidemiology* / Q000662:veterinary*; D011820:Rabies virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013997:Time Factors
chemical_list: D019590:Nucleocapsid Proteins; D012367:RNA, Viral; C099601:nucleocapsid protein, Rabies virus