title: Effectiveness of the combined use of lactic acid film and polypropylene mesh in the formation of intraperitoneal adhesions--an experimental model in rats.
abstract: OBJECTIVE
  To evaluate the efficacy of a lactic acid biomaterial (SurgiWrap®) as a protector of the polypropylene mesh (Marlex®) regarding the formation of intraperitoneal adhesions in rats.
  
  
  METHODS
  Forty Wistar rats formed the following groups: Group 0 (Sham)--only laparotomy; Group I--polypropylene mesh; Group II--polypropylene mesh protected by a film of lactic acid. These animals were submitted to laparotomy and placement (or not) of the meshes at closing. After 21 days they were sacrificed for analysis of the adhesion type (0-3), percentage of affected area and strength needed to rupture.
  
  
  RESULTS
  Group 0 showed no intraperitoneal adhesions. Regarding classification, type 3 adhesions had the highest prevalence in both groups 1 and 2. As for the strength to break adhesions, Group 1 had an average of 1.58 N and Group 2, 1.23 N. The mesh was surrounded by adhesions in more than 50% of their surface area in 87% of Group 1 subjects and in 84% of Group 2 individuals. Through different statistical methods we found that there was no significant difference between groups for both variables.
  
  
  CONCLUSIONS
  The combined use of polypropylene mesh and lactic acid bioprotector showed similar results in relation to intraperitoneal adhesion formation when compared to the sole use of the same mesh.
authors.affiliation: Lutheran University of Brazil, Canoas, RS, Brazil.
authors.forename: Marcelo Bentacor
authors.initials: MB
authors.lastname: Lontra
authors.forename: André Vicente
authors.initials: AV
authors.lastname: Bigolin
authors.forename: Ricardo Gonçalves da
authors.initials: RG
authors.lastname: Costa
authors.forename: João Vicente
authors.initials: JV
authors.lastname: Grossi
authors.forename: Priscila
authors.initials: P
authors.lastname: Scalco
authors.forename: Sérgio
authors.initials: S
authors.lastname: Roll
authors.forename: Leandro Totti
authors.initials: LT
authors.lastname: Cavazzola
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D004867:Equipment Design; D019344:Lactic Acid; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D011126:Polypropylenes; D019344:Lactic Acid