title: Anti-fouling bioactive surfaces.
abstract: Bioactive surfaces refer to surfaces with immobilized bioactive molecules aimed specifically at promoting or supporting particular interactions. Such surfaces are of great importance for various biomedical and biomaterials applications. In the past few years, considerable effort has been made to create bioactive surfaces by forming specific biomolecule-modified surfaces on a non-biofouling "base" or "background". Hydrophilic and bioinert polymers have been widely used as anti-fouling layers that resist non-specific protein interactions. They can also serve as "spacers" to effectively move the immobilized biomolecule away from the surface, thus enhancing its bioactivity. In this review we summarize several successful approaches for the design and preparation of bioactive surfaces based on different types of anti-fouling/spacer materials. Some perspectives on future research in this area are also presented.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yu
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.forename: John
authors.initials: J
authors.lastname: Brash
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D057219:Biofouling / Q000517:prevention & control*; D017665:Hydroxyl Radical / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D017665:Hydroxyl Radical; D011092:Polyethylene Glycols