title: Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension.
abstract: This study compared the effects of intravenous infusions of phenylephrine and mephentermine on the prevention of maternal hypotension and neonatal outcome in patients receiving spinal anaesthesia for caesarean section. Sixty ASA 1-2 patients with term, uncomplicated singleton pregnancy undergoing caesarean section under spinal anaesthesia were randomly divided into two groups of 30 each, to receive a prophylactic intravenous infusion of either phenylephrine or mephentermine. The incidence of hypotension was statistically similar in the two groups. However, in patients receiving phenylephrine, 7 (23%) developed bradycardia and 6 (20%), reactive hypertension. Neonatal outcome, in terms of Apgar scores and umbilical artery pH, was similar in both the groups. To conclude, phenylephrine and mephentermine infusions are equally effective in preventing post spinal hypotension in patients undergoing caesarean section and are associated with a similar neonatal outcome.
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India. medhamohta@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Mohta
authors.forename: S Sai
authors.initials: SS
authors.lastname: Janani
authors.forename: A K
authors.initials: AK
authors.lastname: Sethi
authors.forename: D
authors.initials: D
authors.lastname: Agarwal
authors.forename: A
authors.initials: A
authors.lastname: Tyagi
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists / Q000627:therapeutic use; D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D002585:Cesarean Section; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D007231:Infant, Newborn; D008616:Mephentermine / Q000627:therapeutic use*; D010656:Phenylephrine / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D008616:Mephentermine