title: Atopic dermatitis-like skin lesions reduced by topical application and intraperitoneal injection of Hirsutenone in NC/Nga mice.
abstract: Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.
authors.affiliation: Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Mi Sook
authors.initials: MS
authors.lastname: Jeong
authors.forename: Sun Eun
authors.initials: SE
authors.lastname: Choi
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Jung Shim
authors.initials: JS
authors.lastname: Kim
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Kim
authors.forename: Kwan Hee
authors.initials: KH
authors.lastname: Park
authors.forename: Do Ik
authors.initials: DI
authors.lastname: Lee
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Joo
authors.forename: Chung Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Hyoweon
authors.initials: H
authors.lastname: Bang
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Young Wook
authors.initials: YW
authors.lastname: Choi
authors.forename: Kap-sok
authors.initials: KS
authors.lastname: Li
authors.forename: Nam Ju
authors.initials: NJ
authors.lastname: Moon
authors.forename: Min Won
authors.initials: MW
authors.lastname: Lee
authors.forename: Seong Jun
authors.initials: SJ
authors.lastname: Seo
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002396:Catechols / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use*; D051546:Cyclooxygenase 2 / Q000097:blood; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000473:pathology*; D036381:Diarylheptanoids / Q000008:administration & dosage / Q000138:chemical synthesis / Q000302:isolation & purification / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004804:Eosinophils / Q000187:drug effects; D005260:Female; D007073:Immunoglobulin E / Q000097:blood; D007274:Injections, Intraperitoneal; D007378:Interleukins / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D052247:Nitric Oxide Synthase Type II / Q000097:blood; D012867:Skin / Q000473:pathology*
chemical_list: D002396:Catechols; D036381:Diarylheptanoids; D007378:Interleukins; C508777:hirsutenone; C409456:oregonin; D007073:Immunoglobulin E; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2