title: Hypertension and angiogenesis in the aging kidney: a review.
abstract: With advanced aging, main components of the kidney are altered, including blood vessels, glomeruli and tubulointerstitium. Disruption in these 3 elements is interconnected and associated with several modifications, such as loss of kidney mass and systemic, metabolic and immunologic diseases. In this review we focus on renal blood vessels, the key role of hypertension and angiogenesis in the elderly kidney, the hemodynamic and molecular mechanisms underlying this aging process and the main factors involved. So far, the present data suggests a strong association between renal disease and hypertension and the impairment of regulatory mechanisms, such as angiogenesis in the aging kidney. The endothelium is a key player in vascular control and appears to be also disrupted in many compensatory functions (i.e., vasodilation). Perspectives for the management of the dysfunctional aging kidney are also addressed.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: Delfim
authors.initials: D
authors.lastname: Duarte
authors.forename: Carla
authors.initials: C
authors.lastname: Santos-Araújo
authors.forename: Adelino F
authors.initials: AF
authors.lastname: Leite-Moreira
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000502:physiology; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply*; D008297:Male; D051379:Mice; D018919:Neovascularization, Physiologic; D009569:Nitric Oxide / Q000502:physiology; D051381:Rats; D012084:Renin-Angiotensin System / Q000502:physiology; D042442:Vascular Endothelial Growth Factors / Q000502:physiology
chemical_list: D042442:Vascular Endothelial Growth Factors; C487735:dimethylarginine; D009569:Nitric Oxide; D001120:Arginine