title: Protective effect of sodium aescinate on lung injury induced by methyl parathion.
abstract: Methyl parathion (MP) is a high venenosus insecticide. It has been used in pest control of agriculture for several years. The present study is performed to investigate the protective effect of sodium aescinate (SA) on lung injury induced by MP. Forty male Sprague-Dawley rats are randomly divided into five groups, with 8 animals in each group: control group, MP administration group, MP plus SA at doses of 0.45 mg/kg, 0.9 mg/kg and 1.8 mg/kg groups. Acetylcholinesterase (AChE) activity and nitric oxide (NO) level in plasma, myeloperoxidase (MPO) activity, NO level, and antioxidative parameters in lung tissue are assayed. Histopathological examination of lung is also performed. The results show that SA has no effect on AChE. Treatment with SA decreases the activity of MPO in lung and the level of NO in plasma and lung. The level of malondialdehyde in lung is decreased after SA treatments. SA increases the activities of superoxide dismutase, glutathione peroxidase and the content of glutathione in lung. SA administration also ameliorates lung injury induced by MP. The findings indicate that SA could protect lung injury induced by MP and the mechanism of action is related to the anti-inflammatory and anti-oxidative effect of SA.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Yantai University, NO. 32, Qingquan Road, Yantai 264005, Shandong, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Du
authors.forename: Tian
authors.initials: T
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Jiang
authors.forename: Ru-Tong
authors.initials: RT
authors.lastname: Ren
authors.forename: De-Lu
authors.initials: DL
authors.lastname: Zhao
authors.forename: Chong
authors.initials: C
authors.lastname: Li
authors.forename: Feng-Hua
authors.initials: FH
authors.lastname: Fu
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D004928:Escin / Q000737:chemistry / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D055370:Lung Injury / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity*; D009569:Nitric Oxide / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D007306:Insecticides; D020011:Protective Agents; D009569:Nitric Oxide; D008743:Methyl Parathion; D004928:Escin; D010088:Oxidoreductases; D005978:Glutathione