title: Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation.
abstract: Mitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with imported subunits that are encoded in the nucleus. New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex.
authors.affiliation: Abteilung für Biochemie II, Universität Göttingen, D-37073 Göttingen, Germany.
authors.forename: David U
authors.initials: DU
authors.lastname: Mick
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Fox
authors.forename: Peter
authors.initials: P
authors.lastname: Rehling
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D008954:Models, Biological; D014176:Protein Biosynthesis / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial; D003576:Electron Transport Complex IV