title: How host defense is encoded in the mammalian genome.
abstract: This issue of Mammalian Genome explores the genetic approach to infectious disease susceptibility as it has been applied in mammals. Although no single issue of any journal could give comprehensive treatment to a field so extensive and rapidly growing as this one, these texts describe key discoveries that provided new understanding of immune responses. Classical genetic studies opened and continue to pave the way to deep understanding of many issues in immunology.
authors.affiliation: Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. bruce@scripps.edu
authors.forename: Bruce
authors.initials: B
authors.lastname: Beutler
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Goodnow
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics; D020022:Genetic Predisposition to Disease; D016678:Genome; D006801:Humans; D007109:Immunity; D008322:Mammals / Q000235:genetics* / Q000276:immunology*