title: [Drug-drug interactions and nephrotoxicity].
abstract: Nephrotoxicity is a common and often clinically relevant adverse drug reaction. Mechanisms include vascular, tubulo-toxic, tubulo-obstructive, and immunological effects. Drug-drug interactions may occur at a pharmacokinetic or pharmacodynamic level. Such interactions can both increase (cisplatin and aminoglycoside) but also protect from nephrotoxicity (cidofovir and probenecid).Important measures for preventing nephrotoxicity are (1) consideration of potential pharmacokinetic and pharmacodynamic interactions when prescribing a drug, (2) prescription of nephrotoxic drugs for the shortest possible period, (3) detection of high-risk patients, and (4) consideration of hydration and prophylactic comedication.
authors.affiliation: Abteilung Klinische Pharmakologie und Pharmakoepidemiologie, Medizinische Klinik, Universitätsklinikum Heidelberg.
authors.forename: David
authors.initials: D
authors.lastname: Czock
authors.forename: Frieder
authors.initials: F
authors.lastname: Keller
mesh_terms: D000617:Aminoglycosides / Q000493:pharmacokinetics / Q000633:toxicity; D000700:Analgesics / Q000493:pharmacokinetics / Q000633:toxicity; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000633:toxicity; D019380:Anti-HIV Agents / Q000493:pharmacokinetics / Q000633:toxicity; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000633:toxicity; D018501:Antirheumatic Agents / Q000493:pharmacokinetics / Q000633:toxicity; D000077404:Cidofovir; D002945:Cisplatin / Q000493:pharmacokinetics / Q000633:toxicity; D003287:Contrast Media / Q000493:pharmacokinetics / Q000633:toxicity; D003404:Creatinine / Q000097:blood; D003596:Cytosine / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000633:toxicity; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D063065:Organophosphonates / Q000493:pharmacokinetics / Q000633:toxicity; D011339:Probenecid / Q000493:pharmacokinetics / Q000633:toxicity; D012307:Risk Factors; D014528:Uricosuric Agents / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D000617:Aminoglycosides; D000700:Analgesics; D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D018501:Antirheumatic Agents; D003287:Contrast Media; D063065:Organophosphonates; D014528:Uricosuric Agents; D003596:Cytosine; D003404:Creatinine; D000077404:Cidofovir; D011339:Probenecid; D002945:Cisplatin