title: The novel prostate cancer antigen 3 (PCA3) biomarker.
abstract: PCA3 is a prostate specific, nonprotein coding RNA that is significantly over expressed in prostate cancer, without any correlation to prostatic volume and/or other prostatic diseases (e.g. prostatitis). It can now easily be measured in urine with a novel transcription-mediated amplification based test. Quantification of PCA3 mRNA levels can predict the outcome of prostatic biopsies with a higher specificity rate in comparison to PSA. Several studies have demonstrated that PCA3 can be used as a prognostic marker of prostate cancer, especially in conjunction with other predictive markers. Novel PCA3-based nomograms have already been introduced into clinical practice. PCA3 test may be of valuable help in several PSA quandary situations such as negative prostatic biopsies, concomitant prostatic diseases, and active surveillance. Results from relevant clinical studies, comparative with PSA, are warranted in order to confirm the perspective of PCA3 to substitute PSA.
authors.affiliation: University Department of Urology, Sismanoglio Hospital, Athens, Greece.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bourdoumis
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papatsoris
authors.forename: Michael
authors.initials: M
authors.lastname: Chrisofos
authors.forename: Eleni
authors.initials: E
authors.lastname: Efstathiou
authors.forename: Andreas
authors.initials: A
authors.lastname: Skolarikos
authors.forename: Charalambos
authors.initials: C
authors.lastname: Deliveliotis
mesh_terms: D000951:Antigens, Neoplasm / Q000652:urine*; D001706:Biopsy; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000652:urine*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; C479341:prostate cancer antigen 3, human; D017430:Prostate-Specific Antigen