title: Long intergenic noncoding RNAs: new links in cancer progression.
abstract: The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.
authors.affiliation: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Miao-Chih
authors.initials: MC
authors.lastname: Tsai
authors.forename: Robert C
authors.initials: RC
authors.lastname: Spitale
authors.forename: Howard Y
authors.initials: HY
authors.lastname: Chang
mesh_terms: D018450:Disease Progression; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D022661:RNA, Untranslated / Q000235:genetics*
chemical_list: D022661:RNA, Untranslated