title: Sigma1 receptor antagonist BD1047 enhances reversal of conditioned place preference from cocaine to social interaction.
abstract: We have previously shown that only four 15-min social interaction episodes with a male adult conspecific reversed cocaine conditioned place preference (CPP) even despite continuing CPP training with cocaine. In the present study, we investigated if BD1047, a sigma1 receptor antagonist that has been shown to inhibit the expression of cocaine CPP, is able to enhance this effect. BD1047, given as a 10-min pretreatment, dose-dependently (ED50 of 0.0036 mg/kg i.p.) decreased the time spent in the previously cocaine-associated compartment in favour of the time spent in the compartment in which a single social interaction had taken place. Our findings indicate that sigma1 blockade may be used therapeutically to enhance treatment adherence in social interaction-based rehabilitation programs.
authors.affiliation: Experimental Psychiatry Unit, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Fritz
authors.forename: Sabine
authors.initials: S
authors.lastname: Klement
authors.forename: Rana
authors.initials: R
authors.lastname: El Rawas
authors.forename: Alois
authors.initials: A
authors.lastname: Saria
authors.forename: Gerald
authors.initials: G
authors.lastname: Zernig
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000628:therapy; D003131:Combined Modality Therapy; D003216:Conditioning, Operant / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005029:Ethylenediamines / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017480:Receptors, sigma / Q000037:antagonists & inhibitors*; D012919:Social Behavior; D000097605:Sigma-1 Receptor
chemical_list: D003042:Cocaine; D018765:Dopamine Uptake Inhibitors; D005029:Ethylenediamines; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor; C097963:N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin