title: Perforated mixed carcinoid-adenocarcinoma in transverse colon and at gastroenterostomy site: case report.
abstract: Goblet cell carcinoid of the large intestine is a rare neoplasm, usually located in ascending colon and rectum. A 60-year-old male patient underwent surgery after the diagnosis of acute abdomen. Exploratory laparotomy revealed perforation with a diameter of 1 cm at the site of the previously performed gastroenterostomy and dilatation of the right colic flexure, secondary to a solid obstructive mass located in the mid-portion of transverse colon. Histopathological investigation of the biopsies, taken from the gastroenterostomy site and the tumor, revealed mixed carcinoid-adenocarcinoma with carcinoid component, predominantly composed of goblet cells. Three cycles of FOLFOX-4 protocol was administered. Following respiratory distress secondary to pulmonary metastasis, the patient's condition deteriorated and subsequently died in the fourth postoperative month. Our aim with this paper is to point out that more cases should be reported for more effective diagnosis, histopathological study, clinical investigation, treatment and prognosis of this specific neoplasm.
authors.affiliation: Department of General Surgery, Eskişehir Osmangazi University, School of Medicine 26480, Eskişehir, Turkey. e.ihtiyar@ogu.edu.tr
authors.forename: Enver
authors.initials: E
authors.lastname: Ihtiyar
authors.forename: Ozgül
authors.initials: O
authors.lastname: Paşaoğlu
authors.forename: Serdar
authors.initials: S
authors.lastname: Erkasap
authors.forename: Barış R
authors.initials: BR
authors.lastname: Karakaş
authors.forename: Fatih N
authors.initials: FN
authors.lastname: Yaşar
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002276:Carcinoid Tumor / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D044684:Colon, Transverse / Q000473:pathology; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000627:therapeutic use; D005763:Gastroenterostomy; D006801:Humans; D007416:Intestinal Perforation / Q000473:pathology*; D007813:Laparotomy; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D011379:Prognosis
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil