title: Effect of the route of foot-and-mouth disease virus infection of piglets on the course of disease.
abstract: Three different routes of Foot-and-mouth disease virus (FMDV) infection of piglets, namely intranasal (i.n.) through drops, intradermal (i.d.) into the foot, and intramuscular (i.m.) were compared regarding the onset and severity of the disease. The results showed that the i.d. injection of the virus resulted in the fastest onset of the disease. The i.m. injection led to a delayed onset, but the final effect was identical with i.d. injection. Moreover, the i.m. injection was simpler to perform and easier to evaluate. Therefore, the i.m. injection of piglets is recommended as the optimal infection route for evaluation of the FMDV vaccine potency.
authors.affiliation: Chinese Academy of Agricultural Sciences, Lanzhou, People's Republic of China. lidongpaul@yahoo.com.cn
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: X W
authors.initials: XW
authors.lastname: Bai
authors.forename: P
authors.initials: P
authors.lastname: Sun
authors.forename: Y F
authors.initials: YF
authors.lastname: Fu
authors.forename: B X
authors.initials: BX
authors.lastname: Xie
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Lu
authors.forename: Y L
authors.initials: YL
authors.lastname: Chen
authors.forename: W J
authors.initials: WJ
authors.lastname: Cao
authors.forename: Z X
authors.initials: ZX
authors.lastname: Liu
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D005536:Foot-and-Mouth Disease / Q000188:drug therapy / Q000821:virology*; D029544:Foot-and-Mouth Disease Virus / Q000472:pathogenicity / Q000502:physiology*; D007271:Injections, Intradermal / Q000379:methods* / Q000662:veterinary; D007273:Injections, Intramuscular / Q000379:methods* / Q000662:veterinary; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000821:virology*; D014765:Viral Vaccines / Q000008:administration & dosage*; D014774:Virulence
chemical_list: D014765:Viral Vaccines