title: Effect of Atorvastatin in radiographic density on alveolar bone loss in wistar rats.
abstract: The purpose of this study was to evaluate the effect of Atorvastatin (ATV) on alveolar bone loss induced in rats. Periodontitis was induced by ligature placement around the upper second left molar in a total of 24 male Wistar rats (± 200 g). Groups of 6 animals received via oral gavage either saline or ATV (1, 3 and 9 mg/kg) during 11 days. After this time, the animals were sacrificed and their maxillae were removed, defleshed, radiographed by Digora System®, and latter stained to be photographed using a digital camera. Data were analyzed statistically by ANOVA and Bonferroni test at 5% significance level and presented as mean ± SEM. ATV (9 mg/kg) caused a significant increase on gray tone variation of over 48% (118.3 ± 12.0 gray tones) when compared to saline (79.8 ± 6.2 gray tones), indicating greater radiographic density. These data were corroborated by macroscopic findings, where ATV (9 mg/kg) reduced alveolar bone loss by over 47% (p<0.05), when compared to the group of untreated animals (saline). In summary, ATV was able to prevent alveolar bone loss seen on a ligature-induced periodontitis model.
authors.affiliation: Department of Clinical Dentistry, Federal University of Ceará, Fortaleza, CE, Brazil.
authors.forename: Paula
authors.initials: P
authors.lastname: Goes
authors.forename: Ana Patrícia Souza
authors.initials: AP
authors.lastname: Lima
authors.forename: Iracema Matos
authors.initials: IM
authors.lastname: Melo
authors.forename: Rodrigo Otávio Citó César
authors.initials: RO
authors.lastname: Rêgo
authors.forename: Vilma
authors.initials: V
authors.lastname: Lima
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D000704:Analysis of Variance; D000818:Animals; D000069059:Atorvastatin; D015519:Bone Density / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006538:Heptanoic Acids / Q000627:therapeutic use*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging; D010518:Periodontitis / Q000150:complications* / Q000188:drug therapy; D011758:Pyrroles / Q000627:therapeutic use*; D019252:Radiography, Dental, Digital / Q000662:veterinary; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin