title: [Experimental studies on antiarrhythmic effect of jumi extraction].
abstract: OBJECTIVE
  To investigate the antiarrhythmic effect of jumi (JM) extraction.
  
  
  METHODS
  The conventional antiarrhythmic methods were used.
  
  
  RESULTS
  Administration of JM extraction reduced the occurrence of ventricular fibrillation induced by chloroform in a dose-dependent manner in mice. Quinidine significantly decreased the number of ventricular premature beats and ventricular tachycardia, shortened the duration of arrhythmia in aconitine-treated rats. But JM extraction had no effect on aconitine-induced arrhythmia. Compared with control, arrhythmia score was lower in ischemia/reperfusion rats which pretreated with 2.0 g/kg of JM extraction.
  
  
  CONCLUSIONS
  JM extraction has obvious protection effects in chloroform- and ischemia-induced arrhythmia, but has no effect in aconitine-induced arrhythmia.
authors.affiliation: Department of Physiology, School of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Xu
authors.forename: Ting-mei
authors.initials: TM
authors.lastname: Ye
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Chen
authors.forename: Yue-liang
authors.initials: YL
authors.lastname: Shen
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000889:Anti-Arrhythmia Agents; D010936:Plant Extracts