title: Cutting edge issues in autoimmune gastritis.
abstract: Autoimmune gastritis is the outcome of a pathological CD4 T cell-mediated autoimmune response directed against the gastric H/K-ATPase. Silent initially, the gastric lesion becomes manifest in humans by the development of megaloblastic pernicious anemia arising from vitamin B12 deficiency. Cutting edge issues in this disease relate to its epidemiology, immunogenetics, a role for Helicobacter pylori as an infective trigger through molecular mimicry, its immunopathogenesis, associated organ-specific autoimmune diseases, laboratory diagnosis, and approaches to curative therapy.
authors.affiliation: Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University, Melbourne, VIC, Australia. Ban-Hock.Toh@monash.edu
authors.forename: Ban-Hock
authors.initials: BH
authors.lastname: Toh
authors.forename: James
authors.initials: J
authors.lastname: Chan
authors.forename: Tin
authors.initials: T
authors.lastname: Kyaw
authors.forename: Frank
authors.initials: F
authors.lastname: Alderuccio
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000453:epidemiology; D000818:Animals; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004789:Enzyme Activation; D005756:Gastritis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D020022:Genetic Predisposition to Disease; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007108:Immune Tolerance; D015994:Incidence; D014820:Vitiligo / Q000453:epidemiology
chemical_list: D017506:H(+)-K(+)-Exchanging ATPase