title: Cell therapy for cardiovascular disease: a comparison of methods of delivery.
abstract: The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods of delivery: systemic infusion, intracoronary infusion, transvenous coronary sinus, and intramyocardial. This review discusses the advantages and disadvantages of the delivery approaches above.
authors.affiliation: Mercy Gilbert and Chandler Regional Medical Centers, 3555 S. Val Vista Dr., Gilbert, AZ 85297, USA. ndib@heartsciencescenter.com
authors.forename: Nabil
authors.initials: N
authors.lastname: Dib
authors.forename: Harris
authors.initials: H
authors.lastname: Khawaja
authors.forename: Samantha
authors.initials: S
authors.lastname: Varner
authors.forename: Megan
authors.initials: M
authors.lastname: McCarthy
authors.forename: Ann
authors.initials: A
authors.lastname: Campbell
mesh_terms: D009202:Cardiomyopathies / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007262:Infusions, Intravenous; D007267:Injections; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000473:pathology*; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome