title: Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs.
abstract: OBJECTIVE
  The aim of the present study was to compare a newly developed biodegradable polylactide/polyglycolide/N-methyl-2-pyrrolidone (PLGA/NMP) membrane with a standard resorbable collagen membrane (RCM) in combination with and without the use of a bone substitute material (deproteinized bovine bone mineral [DBBM]) looking at the proposed tenting effect and bone regeneration.
  
  
  METHODS
  In five adult German sheepdogs, the mandibular premolars P2, P3, P4, and the molar M1 were bilaterally extracted creating two bony defects on each site. A total of 20 dental implants were inserted and allocated to four different treatment modalities within each dog: PLGA/NMP membrane only (Test 1), PLGA/NMP membrane with DBBM (Test 2), RCM only (negative control), and RCM with DBBM (positive control). A histomorphometric analysis was performed 12 weeks after implantation. For statistical analysis, a Friedman test and subsequently a Wilcoxon signed ranks test were applied.
  
  
  RESULTS
  In four out of five PLGA/NMP membrane-treated defects, the membranes had broken into pieces without the support of DBBM. This led to a worse outcome than in the RCM group. In combination with DBBM, both membranes revealed similar amounts of area of bone regeneration and bone-to-implant contact without significant differences. On the level of the third implant thread, the PLGA/NMP membrane induced more horizontal bone formation beyond the graft than the RCM.
  
  
  CONCLUSIONS
  The newly developed PLGA/NMP membrane performs equally well as the RCM when applied in combination with DBBM. Without bone substitute material, the PLGA/NMP membrane performed worse than the RCM in challenging defects, and therefore, a combination with a bone substitute material is recommended.
authors.affiliation: Department of Fixed and Removable Prosthodontics and Dental Material Science, Dental School, University of Zurich, Zurich, Switzerland. ronald.jung@zzmk.uzh.ch
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Jung
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kokovic
authors.forename: Milan
authors.initials: M
authors.lastname: Jurisic
authors.forename: Duygu
authors.initials: D
authors.lastname: Yaman
authors.forename: Karthikeyan
authors.initials: K
authors.lastname: Subramani
authors.forename: Franz E
authors.initials: FE
authors.lastname: Weber
mesh_terms: D020341:Absorbable Implants; D000540:Alveolar Ridge Augmentation / Q000379:methods; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D002417:Cattle; D003094:Collagen; D003758:Dental Implantation, Endosseous / Q000379:methods; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry; D008334:Mandible / Q000601:surgery; D008567:Membranes, Artificial; D008903:Minerals / Q000737:chemistry; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry; D011897:Random Allocation; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D011108:Polymers; D011760:Pyrrolidinones; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003094:Collagen; C038678:N-methylpyrrolidone