title: Submandibular salivary glands: influence on growth rate and life span in mice.
abstract: Submandibular glands accumulate a variety of growth factors, especially in male mice. Surgical excision of these glands (sialoadenectomy) results in alterations in several organs and systems including the liver, skin and reproductive system. We studied the life-long consequences of sialoadenectomy in male mice. Animals were operated at the age of 10 weeks. Thereafter, body weight and food and water intake were controlled until death. Few weeks after surgery, body weight was lower in sialoadenectomized than in control mice. The difference remained stable until the age of 80 weeks. In spite of the lower body weight, food intake was higher in sialoadenectomized mice than in controls. The first death of sialoadenectomized mice occurred 10 weeks earlier than that of the first control, and the initial death rate in sialoadenectomized mice was almost twice the rate in controls. After 100 weeks of life, the death rate increased in control mice, but suddenly decreased in sialoadenectomized mice. The consequence was that the mean life span of the last 25% surviving animals was 10 weeks longer in sialoadenectomized than in control mice. Autopsy examination suggests that the effect of sialoadenectomy on death rate may be the consequence of a contrasting effect on tumour growth. Our results indicate that submandibular glands, or rather the factors derived from these glands, have contrasting roles in tumour growth. At early ages they may be survival factors and protect tissues, whereas at later ages they may stimulate the growth of transformed cells.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain. iramirez@ub.edu
authors.forename: Ignasi
authors.initials: I
authors.lastname: Ramírez
authors.forename: Maria
authors.initials: M
authors.lastname: Soley
mesh_terms: D000367:Age Factors; D000818:Animals; D017209:Apoptosis; D001835:Body Weight; D008136:Longevity; D008297:Male; D051379:Mice; D009929:Organ Size / Q000502:physiology; D013363:Submandibular Gland / Q000378:metabolism* / Q000601:surgery