title: DNA replication: making two forks from one prereplication complex.
abstract: The copying of chromosomal DNA initiates from a single nucleoprotein assembly called the prereplication complex. New findings in a recent issue of Molecular Cell (Yardimci et al., 2010) reveal that this complex dissolves into two independent replisomes that move away from each other as DNA synthesis ensues.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. mbotchan@berkeley.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Botchan
authors.forename: James
authors.initials: J
authors.lastname: Berger