title: Cross-talk between tumor and myeloid cells: how to tip the balance in favor of antitumor immunity.
abstract: Myeloid differentiation is often disturbed in cancer, leading to reduced frequencies of immunostimulatory dendritic cells and an over-representation of immunosuppressive immature myeloid cells, granulocytes and macrophages. As a result of this skewed myeloid differentiation, a highly immunosuppressive myeloid subset becomes prevalent during cancer development; these myeloid-derived suppressor cells are also recruited as a collateral to certain protumorigenic inflammatory processes, resulting in an effective downregulation of T-cell-mediated immune surveillance and antitumor immunity. In this article, some of the important myeloid cell subsets and mediators involved in cancer-related immune suppression are reviewed. Furthermore, cross-talk between tumors and the myeloid compartment, and ways in which it can suppress effective cell-mediated immunity, are discussed, as well as possible therapeutic approaches to tip the balance in favor of antitumor immunity.
authors.affiliation: Department of Medical Oncology, Immunotherapy Laboratory, VU University Medical Center CCA2.22, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
authors.forename: Jelle J
authors.initials: JJ
authors.lastname: Lindenberg
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Fehres
authors.forename: Hester
authors.initials: H
authors.lastname: van Cruijsen
authors.forename: Dinja
authors.initials: D
authors.lastname: Oosterhoff
authors.forename: Tanja D
authors.initials: TD
authors.lastname: de Gruijl
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007165:Immunosuppression Therapy; D051379:Mice; D022423:Myeloid Cells / Q000166:cytology* / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*