title: Short-segment Barrett's esophagus and cardia intestinal metaplasia: A comparative analysis.
abstract: OBJECTIVE
  to investigate the endoscopy and histology of short-segment Barrett's esophagus (SSBE) and cardia intestinal metaplasia (CIM), and their correlation with Helicobacter pylori (H. pylori) gastritis and gastroesophageal reflux disease (GERD).
  
  
  METHODS
  biopsy specimens were taken from 32 SSBE patients and 41 CIM patients with normal appearance of the esophagogastric junction. Eight biopsy specimens from the lower esophagus, cardia, and gastric antrum were stained with hematoxylin/eosin, Alcian blue/periodic acid-Schiff, Alcian blue/high iron diamine and Gimenez dye. Results were graded independently by one pathologist.
  
  
  RESULTS
  the SSBE patients were younger than the CIM patients (P < 0.01). The incidence of dysplasia and incomplete intestinal metaplasia subtype was higher in SSBE patients than in CIM patients (P < 0.01). H. pylori infection was correlated with antral intestinal metaplasia (P < 0.05), but not with reflux symptomatic, endoscopic, or histological markers of GERD in CIM patients. SSBE was correlated with reflux symptomatic and endoscopic esophagitis (P < 0.01), but not with H. pylori infection and antral intestinal metaplasia.
  
  
  CONCLUSIONS
  dysplasia risk is significantly greater in SSBE patients than in CIM patients. CIM is a manifestation of H. pylori-associated and multifocal atrophic gastritis, whereas SSBE may result from GERD.
authors.affiliation: Digestive Endoscopic Center, Shanghai Sixth Hospital, Shanghai Jiao Tong University, Yishan Road 600, Shanghai 200233, China. mulan929@hotmail.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Chang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
mesh_terms: D001471:Barrett Esophagus / Q000209:etiology / Q000473:pathology*; D002299:Cardia / Q000473:pathology*; D004724:Endoscopy; D005764:Gastroesophageal Reflux / Q000150:complications / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications / Q000473:pathology; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008679:Metaplasia / Q000209:etiology / Q000473:pathology*; D012307:Risk Factors