title: Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides.
abstract: The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron-poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and solvent is required for achieving best results.
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204, United States.
authors.forename: Enrico T
authors.initials: ET
authors.lastname: Nadres
authors.forename: Anna
authors.initials: A
authors.lastname: Lazareva
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis
mesh_terms: D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D005663:Furans; D006843:Hydrocarbons, Chlorinated; D007211:Indoles; D008024:Ligands; D011758:Pyrroles; D012997:Solvents; D010165:Palladium; C030374:indole; C039281:furan