title: [Effects of ligustrazin on lipid peroxidation during hepatic ischemia reperfusion injury].
abstract: OBJECTIVE
  To explore the role of ligustrazin on dynamic changes of lipid peroxidation in hepatic ischemia/reperfusion injury (HIRI) and its mechanism.
  
  
  METHODS
  The HIRI model was used. Twenty rabbits were randomly divided into control group (n = 10) and ligustrazin group (n = 10). The xanthine oxidase (XO) activity, superoxide dismutase (SOD) activity,malondialdehyde (MDA) content and glutamic pyruvic transaminase (GPT) activity in plasma were observed before ischemia and at ischemia 25 min, reperfusion 25 min, reperfusion 60 min and reperfusion 120 min.
  
  
  RESULTS
  The XO activity, SOD activity, MDA content and GPT activity of ligustrazin group, as compared with control group, showed significant differences (P < 0.05 or P < 0.01) at total time points of reperfusion.
  
  
  CONCLUSIONS
  Ligustrazin has notable anti-lipid peroxidation effect on HIRI, which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.
authors.affiliation: Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325027, China.
authors.forename: Zheng-Jie
authors.initials: ZJ
authors.lastname: Xu
authors.forename: Wan-Tie
authors.initials: WT
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Lin
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D011719:Pyrazines / Q000494:pharmacology*; D011817:Rabbits; D015427:Reperfusion Injury / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D011719:Pyrazines; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D000410:Alanine Transaminase; C017953:tetramethylpyrazine