title: Design and synthesis of anti-MRSA benzimidazolylbenzene-sulfonamides. QSAR studies for prediction of antibacterial activity.
abstract: A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.
authors.affiliation: Programa de Doctorado en Ciencias Biológicas, Universidad Autónoma Metropolitana, México DF, Mexico.
authors.forename: Marco Martín
authors.initials: MM
authors.lastname: González-Chávez
authors.forename: Francisco
authors.initials: F
authors.lastname: Méndez
authors.forename: Roberto
authors.initials: R
authors.lastname: Martínez
authors.forename: Cuaúhtemoc
authors.initials: C
authors.lastname: Pérez-González
authors.forename: Fidel
authors.initials: F
authors.lastname: Martínez-Gutiérrez
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D013057:Spectrum Analysis / Q000379:methods; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides