title: Elucidation of the biosynthesis and degradation of allantofuranone by isotopic labelling and fermentation of modified precursors.
abstract: Feeding experiments with the ascomycete Allantophomopsis lycopodina indicated that the potent fungistatic allantofuranone is biosynthesized from phenylalanine. Further experiments with synthetic precursors gave evidence that the naturally occurring polyporic acid serves as a key intermediate in the biosynthesis. In addition to the formation of allantofuranone, its abiotic and metabolic degradation were investigated.
authors.affiliation: Institut für Biotechnologie und Wirkstoff-Forschung e.V. Erwin-Schroedinger-Strasse 56, 67663 Kaiserslautern, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Schüffler
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Liermann
authors.forename: Till
authors.initials: T
authors.lastname: Opatz
authors.forename: Timm
authors.initials: T
authors.lastname: Anke
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000935:Antifungal Agents / Q000378:metabolism* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects / Q000378:metabolism*; D007553:Isotope Labeling
chemical_list: D000935:Antifungal Agents; C544237:allantofuranone; D015107:4-Butyrolactone