title: [Relationship between expression of VEGF-C and lymph node metastasis in human non-small cell lung cancer].
abstract: BACKGROUND
  It has been showed that VEGF-C can induce the proliferation of lymphocytes. The aim of this study is to explore the expression of VEGF-C in human non-small cell lung can-cer (NSCLC) and its relationship with lymph node metastasis.
  
  
  METHODS
  The expression of VEGF-C was examined in 60 human NSCLC tissues by immunohistochemical technique..
  
  
  RESULTS
  The positive rate of VEGF-C expression was 65.00% (39/60) in NSCLC tissues. The expression of VEGF-C was significantly higher in cases with lymph node metastasis (83.33%, 20/24) than in those without lymph node metastasis (52.78%, 19/36) (P < 0.05).
  
  
  CONCLUSIONS
  There is an overexpression of VEGF-C protein in human NSCLC tissues, which may correlate with lymph node metastasis. The expression of VEGF-C protein might be used as a useful mar- ker of lymph node metastasis in NSCLC.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, The First People's Hospital of Yunnan province, Kunming, Yunnan 650032, P.R.China.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Xinlong
authors.initials: X
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Peng