title: [Clinical study of the effect of amnion membrane transplantation on diminishing corneal neovascularization induced by alkali burn].
abstract: OBJECTIVE
  To study the curative effect of amnion membrane transplantation on decreasing corneal neovascularization(CNV) induced by alkali burn.
  
  
  METHODS
  It was a non-randomized retrospective case-control study. Among 19 cases (23 eyes) of third-degree alkali burns from 2006 to 2010, 11 cases (13 eyes) were performed with amnion membrane transplantation operation, and others were not. Amnion membrane transplantation was performed at 3rd day after burns in the treatment group. Ages and treatments beyond surgery of double groups were matched. Areas of CNV in double groups were measured at the 14th and 60th days after burn. RESULTS：Area of CNV in the treatment group was (62.133±8.571) mm² at the 14th day after burn, and was 30.6% lower than that in the control group. Area of CNV in the treatment group was (112.019±17.362)mm² at the 14th day after burn, and was 13.5% lower than that in the control group. There was statistical significance between the two groups (P<0.05).
  
  
  CONCLUSIONS
  Amnion membrane transplantation operation can inhibit the growth of corneal neovascularization induced by alkali burn.
authors.affiliation: Department of Ophthalmology,the First Affiliated Hospital of The General Hospital of PLA,Beijing 100048,China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yin
authors.forename: Yuli
authors.initials: Y
authors.lastname: Pi
mesh_terms: D000468:Alkalies; D000650:Amnion / Q000637:transplantation; D002057:Burns, Chemical; D016022:Case-Control Studies; D016510:Corneal Neovascularization; D005126:Eye Burns / Q000601:surgery; D006801:Humans; D012189:Retrospective Studies
chemical_list: D000468:Alkalies