title: [Neural stem cells transplantation improved learning and memory abilities in Alzheimer's disease rat].
abstract: OBJECTIVE
  To investigate whether transplantation of neural stem cells can ameliorate learning and memory abilities in Alzheimer's disease (AD) rats.
  
  
  METHODS
  Neural stem cells were isolated from dentate gyrus of hippocampus of newborn rats. After labeled with Hoechst33258, neural stem cells were grafted into the hippocampus of AD rats. 2 or 4 weeks post transplantation, the rats underwent behavioral testing using Y-maze trial. Fluorescence observation and immunohistochemistry were used after the rats were sacrificed.
  
  
  RESULTS
  Neural stem cells grafted into hippocampus of AD rats could not only survive well, but also possessed the capacity of continuous proliferation and migrate along the hippocampus.
  
  
  CONCLUSIONS
  Neural stem cells grafted into hippocampus of AD rats can not only survive well, possess the capacity of continuous proliferation, but also ameliorate memory defects in Alzheimer's disease rats.
authors.affiliation: Department of Physiology, Medical College of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Shu-chun
authors.initials: SC
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Qiao
authors.forename: Zhao
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000601:surgery*; D000818:Animals; D004195:Disease Models, Animal; D006624:Hippocampus / Q000601:surgery*; D008297:Male; D018782:Maze Learning; D008568:Memory; D058953:Neural Stem Cells / Q000637:transplantation*; D009474:Neurons / Q000637:transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D033581:Stem Cell Transplantation