title: [RRM1 expression in tissue microarray and prognosis analysis in non-small cell lung cancer].
abstract: BACKGROUND
  RRM1 may be a prognostic factor in non-small cell lung cancer (NSCLC). The aim of this study is to evaluate RRM1 expression and prognosis in NSCLC by the means of tissue microarray.
  
  
  METHODS
  A total of 417 paraffin-embedded specimens of NSCLC from Lung Cancer Study Center in Guangdong Provincial People's Hospital were collected and tissue microarray was constructed. RRM1 expression was detected by SP method and its correlation with prognosis was evaluated.
  
  
  RESULTS
  No statistic difference was found in RRM1 expression in different gender, age, tumor site, histology, differentiation, T stage, N stage, M stage and pTNM stage groups (P > 0.05). Univariate analysis showed that RRM1 was not an independent prognostic factor (P > 0.05). At the multivariate analysis, differentiation and N stage were considered independent prognostic factors.
  
  
  CONCLUSIONS
  RRM1 expression detected by immunohistology is not an independent prognostic factor in NSCLC. TNM stage is still the best prognostic factor up to now.
authors.affiliation: Cancer Center, Lung Neoplasm Department, Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510080, P.R.China.
authors.forename: Riqiang
authors.initials: R
authors.lastname: Liao
authors.forename: Jiaying
authors.initials: J
authors.lastname: Lin
authors.forename: Guibin
authors.initials: G
authors.lastname: Qiao
authors.forename: Xinlan
authors.initials: X
authors.lastname: Luo
authors.forename: Jingji
authors.initials: J
authors.lastname: Yang
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wu