title: Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity.
abstract: Although there are several studies dealing with erythrocyte deformability (ED) in obese patients, research on this topic in morbidly obese subjects is scarce. In these studies ED seems to be decreased, although the cause remains unknown. A case-control study in 76 morbid obese subjects (23 women and 53 men, aged 44 ± 13 years) and in 79 normal-weight controls (30 women and 49 men, aged 43 ± 13 years) was undertaken. ED has been determined by ektacytometric techniques in a Rheodyn SSD, by means of the elongation index (EI) at 12, 30 and 60 Pascals, along with anthropometric, lipidic, metabolic and inflammatory parameters. EI was statistically lower in morbidly obese subjects than in controls at all the shear stresses tested (EI12: 47.3 ± 2.14 vs. 47.9 ± 2.07; p = 0.047, EI30: 52.16 ± 2.1 vs. 53.12 ± 1.4; p = 0.007, EI60: 53.9 ± 2.4 vs. 55.2 ± 2.50; p = 0.001) as were anthropometric lipidic and inflammatory parameters (p < 0.001). In the bivariate correlation EI60 correlated negatively with most anthropometric, lipidic and inflammatory parameters. However, in the multivariate analysis, the case-control status was not significantly associated with EI60 and only triglycerides, glucose, hs-CRP and waist circumference were independently associated with EI60, constituting independent predictors of altered ED although, waist circumference, showed the highest statistical significance (p = 0.007). ED is decreased in morbidly obese subjects associated with insulin resistance and inflammation parameters although abdominal obesity seems to be of paramount importance in altering this rheological parameter.
authors.affiliation: Hemorheology and Haemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain. vaya amp@gva.es
authors.forename: Amparo
authors.initials: A
authors.lastname: Vayá
authors.forename: Rosa
authors.initials: R
authors.lastname: Cámara
authors.forename: Antonio
authors.initials: A
authors.lastname: Hernádez-Mijares
authors.forename: Marco
authors.initials: M
authors.lastname: Romagnoli
authors.forename: Eva
authors.initials: E
authors.lastname: Solá
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
authors.forename: Begoña
authors.initials: B
authors.lastname: Laiz
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D016022:Case-Control Studies; D004907:Erythrocyte Deformability; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood*; D009767:Obesity, Morbid / Q000097:blood*; D055105:Waist Circumference