title: New bioinspired membrane made of a biological ion channel confined into the cylindrical nanopore of a solid-state polymer.
abstract: A hybrid nanoporous membrane made of a solid-state polymeric thin film in which an ion channel is confined is realized. The primary and extremely encouraging results obtained by confocal fluorescence spectroscopy and ion diffusion measurement demonstrate respectively that (i) the considered ion channel, that is, Gramicidin-A, can be confined selectively inside the nanopores and (ii) the ionic permeability of the membrane is enhanced. Atomistic molecular simulations are also reported and fruitfully compared to the experimental findings.
authors.affiliation: Institut Charles Gerhardt, UMR 5253, CNRS-UM2-ENSCM-UM1, Montpellier, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Balme
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Janot
authors.forename: Lydie
authors.initials: L
authors.lastname: Berardo
authors.forename: François
authors.initials: F
authors.lastname: Henn
authors.forename: Daniel
authors.initials: D
authors.lastname: Bonhenry
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kraszewski
authors.forename: Fabien
authors.initials: F
authors.lastname: Picaud
authors.forename: Christophe
authors.initials: C
authors.lastname: Ramseyer
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D006096:Gramicidin / Q000737:chemistry*; D007473:Ion Channels / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008567:Membranes, Artificial; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D016062:Porosity; D013499:Surface Properties
chemical_list: D007473:Ion Channels; D046911:Macromolecular Substances; D008567:Membranes, Artificial; D006096:Gramicidin