title: Optimal management of familial hypercholesterolemia: treatment and management strategies.
abstract: Familial hypercholesterolemia is an autosomally dominant disorder caused by various mutations in low-density lipoprotein receptor genes. This will lead to elevated levels of total and low-density lipoprotein cholesterol, which may in turn lead to premature coronary atherosclerosis and cardiac-related death. The symptoms are more severe in the homozygous type of the disease. Different options for the treatment of affected patients are now available. Diet therapy, pharmacologic therapy, lipid apheresis, and liver transplantation are among the various treatments. We clinically review the treatment and management strategies for the disease in order to shed light on the optimal management of familial hypercholesterolemia.
authors.affiliation: Cardiac Surgery Department, Faghihi Hospital, Shiraz, Iran.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Nemati
authors.forename: Behrooz
authors.initials: B
authors.lastname: Astaneh
mesh_terms: D001781:Blood Component Removal; D015897:Comorbidity; D004032:Diet; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006938:Hyperlipoproteinemia Type II / Q000175:diagnosis / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D016031:Liver Transplantation; D015201:Meta-Analysis as Topic
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008077:Lipoproteins, LDL