title: [Respiratory syncytial virus infection enhances airway hyperresponsiveness in guinea pigs and the underlined mechanism].
abstract: OBJECTIVE
  To study the relation between Respiratory Syncytial Virus infection and asthma development by measuring airway responsiveness (AR) and M2R function.
  
  
  METHODS
  Guinea pigs (n = 34) were randomly divided into 4 groups: Hep-2/NS group (group A, n = 9), RSV/NS group (group B, n =9), Hep-2/OVA group (group C, n = 8) and RSV/OVA group(group D, n = 8). On day 21 after infection we tested AR and M2R. Then counted eosinophils in BALF and observed pathological change.
  
  
  RESULTS
  Intraairway pressure(IP mmH20) of group B had no significant difference with group A(P > 0.01), and the extent of IP decrease also had no difference between groups A and B (P > 0. 05), but IP of C group were much higher than group A (P<0.05), with extent of IP decrease lower than group A (P < 0.05). And IP of group D were higher than group C (P < 0.01), with the extent of IP decrease much lower than group C (P < 0.05).
  
  
  CONCLUSIONS
  RSV infection could enhance OVA-induced M2R dysfunction, then develop AHR.
authors.affiliation: Respiratory Department,Xijing Hospital, Fourth Military Medical University, Xi'an, China).
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Fang
authors.forename: Hao-Wen
authors.initials: HW
authors.lastname: Qi
authors.forename: Han-Jun
authors.initials: HJ
authors.lastname: Lin
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Li
authors.forename: Dong-Liang
authors.initials: DL
authors.lastname: Xu
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D016535:Bronchial Hyperreactivity / Q000276:immunology* / Q000503:physiopathology* / Q000821:virology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D011897:Random Allocation; D043585:Receptor, Muscarinic M2 / Q000502:physiology; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology*; D012136:Respiratory Syncytial Viruses / Q000276:immunology
chemical_list: D043585:Receptor, Muscarinic M2; D010047:Ovalbumin