title: Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes.
abstract: A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.
authors.affiliation: Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad, 500 049, India.
authors.forename: Mohosin
authors.initials: M
authors.lastname: Layek
authors.forename: Appi
authors.initials: A
authors.lastname: Reddy M
authors.forename: A V Dhanunjaya
authors.initials: AV
authors.lastname: Rao
authors.forename: Mallika
authors.initials: M
authors.lastname: Alvala
authors.forename: M K
authors.initials: MK
authors.lastname: Arunasree
authors.forename: Aminul
authors.initials: A
authors.lastname: Islam
authors.forename: K
authors.initials: K
authors.lastname: Mukkanti
authors.forename: Javed
authors.initials: J
authors.lastname: Iqbal
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D002384:Catalysis; D003500:Cyclization; D004789:Enzyme Activation / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis*; D056564:Sirtuin 1 / Q000378:metabolism
chemical_list: C545227:2,3-dihydroquinolin-4(1H)-one; D006575:Heterocyclic Compounds, 3-Ring; D019216:Metals, Heavy; D011758:Pyrroles; D015363:Quinolones; C447939:SIRT1 protein, human; D056564:Sirtuin 1