title: The Genomic HyperBrowser: inferential genomics at the sequence level.
abstract: The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled approach to statistical analysis of sequence-level genomic information. We provide a growing collection of generic biological investigations that query pairwise relations between tracks, represented as mathematical objects, along the genome. The Genomic HyperBrowser implements the approach and is available at http://hyperbrowser.uio.no.
authors.affiliation: Department of Informatics, University of Oslo, Blindern, 0316 Oslo, Norway. geirksa@ifi.uio.no
authors.forename: Geir K
authors.initials: GK
authors.lastname: Sandve
authors.forename: Sveinung
authors.initials: S
authors.lastname: Gundersen
authors.forename: Halfdan
authors.initials: H
authors.lastname: Rydbeck
authors.forename: Ingrid K
authors.initials: IK
authors.lastname: Glad
authors.forename: Lars
authors.initials: L
authors.lastname: Holden
authors.forename: Marit
authors.initials: M
authors.lastname: Holden
authors.forename: Knut
authors.initials: K
authors.lastname: Liestøl
authors.forename: Trevor
authors.initials: T
authors.lastname: Clancy
authors.forename: Egil
authors.initials: E
authors.lastname: Ferkingstad
authors.forename: Morten
authors.initials: M
authors.lastname: Johansen
authors.forename: Vegard
authors.initials: V
authors.lastname: Nygaard
authors.forename: Eivind
authors.initials: E
authors.lastname: Tøstesen
authors.forename: Arnoldo
authors.initials: A
authors.lastname: Frigessi
authors.forename: Eivind
authors.initials: E
authors.lastname: Hovig
mesh_terms: D020029:Base Pairing; D019295:Computational Biology / Q000379:methods*; D005091:Exons; D015870:Gene Expression; D016678:Genome; D023281:Genomics / Q000379:methods*; D006657:Histones / Q000378:metabolism; D008954:Models, Biological; D009691:Nucleic Acid Denaturation; D020641:Polymorphism, Single Nucleotide; D017421:Sequence Analysis / Q000379:methods*; D012984:Software
chemical_list: D006657:Histones