title: Kinetochores: NDC80 toes the line.
abstract: Kinetochore-associated NDC80 complexes serve as the primary binding site for the plus-ends of spindle microtubules in mitosis. A recent study proposes a novel mechanism for regulating kinetochore-microtubule binding involving NDC80 complex oligomerization, which could be mediated by Aurora B kinase.
authors.affiliation: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80525, USA.
authors.forename: Lynsie J R
authors.initials: LJ
authors.lastname: Sundin
authors.forename: Jennifer G
authors.initials: JG
authors.lastname: Deluca
mesh_terms: D064107:Aurora Kinase B; D064127:Aurora Kinases; D003598:Cytoskeletal Proteins; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism
chemical_list: D003598:Cytoskeletal Proteins; C120529:NDC80 protein, human; D009687:Nuclear Proteins; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases