title: Hypoxia. 4. Hypoxia and ion channel function.
abstract: The ability to sense and respond to oxygen deprivation is required for survival; thus, understanding the mechanisms by which changes in oxygen are linked to cell viability and function is of great importance. Ion channels play a critical role in regulating cell function in a wide variety of biological processes, including neuronal transmission, control of ventilation, cardiac contractility, and control of vasomotor tone. Since the 1988 discovery of oxygen-sensitive potassium channels in chemoreceptors, the effect of hypoxia on an assortment of ion channels has been studied in an array of cell types. In this review, we describe the effects of both acute and sustained hypoxia (continuous and intermittent) on mammalian ion channels in several tissues, the mode of action, and their contribution to diverse cellular processes.
authors.affiliation: Div. of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. shimodal@welch.jhu.edu
authors.forename: Larissa A
authors.initials: LA
authors.lastname: Shimoda
authors.forename: Jan
authors.initials: J
authors.lastname: Polak
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002490:Central Nervous System / Q000378:metabolism / Q000502:physiology; D002628:Chemoreceptor Cells / Q000378:metabolism / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D051381:Rats
chemical_list: D007473:Ion Channels