title: [Clinical characteristics and operative effect of hippocampus lesions].
abstract: OBJECTIVE
  To study the clinical characteristics and operative effect of hippocampus lesions.
  
  
  METHODS
  We retrospectively analyzed the clinical characteristics and operative outcome of 44 patients with hippocampus lesions between August 2005 and April 2010.
  
  
  RESULTS
  Seizure attack was the initial symptom among 40 of the 44 patients. Pathological examinations revealed 18 gliomas, 9 cavernous malformations, 12 hippocampus sclerosis, 2 focal cortical dysplasia, 1 atypical hyperplasia, 1 injury glial scar, and 1 encephalomalacia. Thirteen patients received anterior medial temporal lobectomy and the other 31 received lesionectomy or selective amygdalohippocampectomy via transsylvian approach. An average of 15.7 month follow-up was accomplished in 37 patients. Postoperative epileptic outcomes were evaluated according to Engel classification: Grade I 73.0%(27/37), Grade II 13.5%(5/37), Grade III 10.8%(4/37) and Grade IV 2.7%(1/37). No perioperative death occurred. One patient experienced hemiplegia but recovered 8 months after the operation. Noticeable postoperative visual field deficit was left in 2 patients. Two patients with glioma died of remote tumor recurrence during follow-up.
  
  
  CONCLUSIONS
  Seizure attack is a major complaint of hippocampus lesions. Satisfactory seizure and tumor control may be achieved through anterior medial temporal lobectomy or selective amygdalohippocampectomy with lesionectomy.
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Xingjun
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Yang
authors.forename: Xianrui
authors.initials: X
authors.lastname: Yuan
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Dun
authors.initials: D
authors.lastname: Yuan
authors.forename: Xuejun
authors.initials: X
authors.lastname: Li
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000601:surgery*; D005260:Female; D005910:Glioma / Q000601:surgery*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012598:Sclerosis / Q000601:surgery; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult