title: Use of Infliximab as rescue therapy in acute severe Ulcerative Colitis with recent norovirus infection.
abstract: OBJECTIVE
  Norovirus infection is a common cause of acute diarrhoeal illness and may occur in the setting of inflammatory bowel disease.
  
  
  METHODS
  A patient with an acute severe first presentation of Ulcerative Colitis failed to settle with intravenous steroids and rescue therapy was considered. The isolation of norovirus in his stool caused concern about aggravating the infection if immunosuppression ensued. Following a brief period of watchful waiting and a full discussion between physician, surgeon and patient, Infliximab was administered (5 mg/kg).
  
  
  RESULTS
  The patient responded well both clinically and biochemically.
  
  
  CONCLUSIONS
  In this case, Infliximab was a safe and efficacious intervention in a patient with acute Ulcerative Colitis and recent norovirus infection.
authors.affiliation: Dept of Gastroenterology, Adelaide and Meath Hospital incorporating the National Children's Hospital/Trinity College Dublin, Belgard Road, Tallaght Dublin 24, Ireland.
authors.forename: J P A
authors.initials: JP
authors.lastname: O'Connor
authors.forename: C A
authors.initials: CA
authors.lastname: O'Moráin
authors.forename: P
authors.initials: P
authors.lastname: Neary
authors.forename: N P
authors.initials: NP
authors.lastname: Breslin