title: Direct nanopatterning of silsesquioxane/poly(ethylene glycol) blends with high stability and nonfouling properties.
abstract: A free-radical-polymerizable SSQ/PEG blend with direct patternability has been proposed as an ideal nonfouling material for nanostructure-based biomedical applications. Cured SSQ/PEG networks show an UV transparency of >90% at 365 nm, high resistance to organic/aqueous solutions, hydrophilicity and Young's moduli of 1.898-2.815 GPa. SSQ/PEG patterns with 25-nm linewidths, 25-nm spacing, and an aspect ratio of 4:1 were directly fabricated on transparent substrates by UV embossing, and cured SSQ/PEG networks with long-term stability under chemical, thermal, and biological stress showed strong resistance to the nonspecific adsorption of biomolecules. These characteristics may offer a new strategy for the development of a number of medical nanodevice applications such as labs-on-a-chip.
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology, Yuseong-gu, Daejeon, Korea.
authors.forename: Bong Kuk
authors.initials: BK
authors.lastname: Lee
authors.forename: Tomoji
authors.initials: T
authors.lastname: Kawai
authors.forename: Bong Hyun
authors.initials: BH
authors.lastname: Chung
mesh_terms: D000327:Adsorption; D055119:Elastic Modulus; D049452:Green Fluorescent Proteins / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008081:Liposomes; D008968:Molecular Conformation; D049329:Nanostructures; D017646:Organosilicon Compounds / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D008081:Liposomes; D017646:Organosilicon Compounds; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D011092:Polyethylene Glycols