title: 2D-speckle tracking echocardiography contributes to early identification of impaired left ventricular myocardial function in patients with chronic kidney disease.
abstract: OBJECTIVE
  Our aim was to investigate left ventricular (LV) physiology and short-axis and long-axis regional LV myocardial function throughout the cardiac cycle with 2D-speckle tracking echocardiography (2D-STE) in patients with chronic kidney disease.
  
  
  METHODS
  The study population consisted of 40 maintenance hemodialysis patients (hemodialysis group), 20 uremic patients hospitalized for creation of primary arteriovenous fistula (nondialysis group), and a control group of 20 healthy volunteers. LV regional longitudinal, circumferential and radial peak systolic velocity (Vs); early diastolic velocity (Ve); and peak systolic strain (ε) were measured with 2D-STE.
  
  
  RESULTS
  Increased LV wall thickness and a decreased E/A ratio were found in the nondialysis and hemodialysis groups as compared to the control group, but there was no difference between the 2 study groups. Longitudinal Vs and Ve of the LV basal segment and middle segment in hemodialysis group and nondialysis group were all slower than those in the control group, and Vs in the nondialysis group was slower than that of the hemodialysis group. Circumferential and radial Vs and Ve were not different among the 3 groups, except that the radial Vs of LV basal segment was markedly decreased in the nondialysis group. Longitudinal peak systolic strain in the hemodialysis and nondialysis groups were both decreased as compared to the control group. Circumferential and radial peak systolic strain was decreased only in the nondialysis group.
  
  
  CONCLUSIONS
  2D-STE may be used to identify early abnormalities in patients with chronic kidney disease who have preserved LV ejection fraction. LV regional function appeared to be better in the hemodialysis group than that in the nondialysis group.
authors.affiliation: Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yan
authors.forename: Haiming
authors.initials: H
authors.lastname: Li
authors.forename: Chuanming
authors.initials: C
authors.lastname: Hao
authors.forename: Haiming
authors.initials: H
authors.lastname: Shi
authors.forename: Yong
authors.initials: Y
authors.lastname: Gu
authors.forename: Guoqian
authors.initials: G
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D042241:Early Diagnosis; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012709:Serum Albumin / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D010446:Peptide Fragments; D012709:Serum Albumin; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002118:Calcium