title: [Transcription expression of endostatin mRNA in non-small cell lung cancer tissues].
abstract: BACKGROUND
  It has been proved that tumor development and metastasis are dependent on angiogenesis. Suppression of tumor angiogenesis can inhibit tumor growth and metastasis. Collagen X VIII/endostatin is one of the most effective inhibitors of angiogenesis at present. The aim of this study is to study the relationship between transcription expression of endostatin mRNA and clinical and pathophysiological characteristics in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  The transcription expression of endostatin mRNA was detected in 46 lung cancer tissues and paracancerous lung tissues, 14 benign pulmonary lesion tissues as control by RT-PCR method.
  
  
  RESULTS
  (1)The transcription expression of endostatin mRNA in lung cancer tissues (0.872±0.071) was significantly higher than that in paracancerous tissues (0.717±0.073) and benign pulmonary lesion tissues (0.611±0.026) (P < 0.001).(2)The transcription expression of endostatin mRNA in lung cancer tissues was closely related to P-TNM stages, distant metastasis, grade of cell differentiation and size of the primary tumors (P < 0.05), but not to location of tumor, lymph node status, histological classification, age and sex of the patients and smoking or not (P > 0.05).
  
  
  CONCLUSIONS
  The transcription expression of endostatin mRNA in NSCLC tissues is significantly higher than that in paracancerous tissues and benign pulmonary lesion tissues, and is closely related to P-TNM stages, distant metastasis, grade of cell differentiation and size of the primary tumors, hence it might be helpful to evaluate the biological behavior of lung cancer.
authors.affiliation: Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province, Department of Thoracocardiac Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
authors.forename: Zhilin
authors.initials: Z
authors.lastname: Sun
authors.forename: Zefang
authors.initials: Z
authors.lastname: Sun
authors.forename: Lunxu
authors.initials: L
authors.lastname: Liu
authors.forename: Wen
authors.initials: W
authors.lastname: Zhu
authors.forename: Yanping
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Chen