title: Asymmetric organocatalytic double-conjugate addition of malononitrile to dienones: efficient synthesis of optically active cyclohexanones.
abstract: 9-Amino-9-deoxyepiquinine efficiently catalyzed the double-conjugate addition of malononitrile to dienones. A number of 1,1,2,6-tetrasubstituted cyclohexanones were prepared in good yields, diastereoselectivities, and excellent enantioselectivities.
authors.affiliation: Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Xue-ming
authors.initials: XM
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Jun-min
authors.initials: JM
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011807:Quinolizines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C517737:9-amino-9-deoxyepiquinine; D000466:Alkadienes; D003512:Cyclohexanones; D009570:Nitriles; D011807:Quinolizines; C000945:dicyanmethane