title: [Adverse drug reactions in children].
abstract: Adverse drug reactions (ADRs) are important safety issues in pediatric pharmacotherapy because they can lead to significant morbidity and mortality in this population. It is currently assumed that the incidence of ADRs in children is between 0.6 % and 19.9 % and that between 0.6 % und 6 % of all hospital admissions of children are triggered by ADRs. Underreporting and insufficient documentation of ADRs in children, however, may obstruct the view on the true numbers. Pharmacovigilance centres in some countries are under way to increase the awareness of the problem. Their programs may help to systematically improve reporting and documentation of ADRs. One important goal is to better assess causality between the patients clinical reaction and drug use, because this is the key knowledge to specifically target an effective and safe pharmacotherapy.
authors.affiliation: Institut für Klinische Pharmazie und Pharmakotherapie, Heinrich-Heine-Universität Düsseldorf.
authors.forename: Linda
authors.initials: L
authors.lastname: Jaffan
authors.forename: Stephanie
authors.initials: S
authors.lastname: Läer
mesh_terms: D000293:Adolescent; D016907:Adverse Drug Reaction Reporting Systems; D000701:Analgesics, Opioid / Q000633:toxicity; D015984:Causality; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D056687:Off-Label Use; D019966:Substance-Related Disorders / Q000175:diagnosis
chemical_list: D000701:Analgesics, Opioid