title: Cardiac cirrhosis and hepatocellular carcinoma in a 13-year-old treated with doxorubicin microbead transarterial chemoembolization.
abstract: Increasing numbers of children are surviving into adulthood following surgery to correct or palliate congenital heart disease. This surgery can occasionally result in long-standing elevated right heart pressures and chronic hepatic venous congestion leading to cardiac cirrhosis. We report the first paediatric case of hepatocellular carcinoma in the setting of cardiac cirrhosis. A 13-year-old girl developed inoperable hepatocellular carcinoma and was treated with transarterial embolization with lipiodol and doxorubicin eluting microbeads. Promoting awareness of this association, even in younger patients, will hopefully result in better surveillance and screening of hepatic complications in survivors of complex cardiac surgery.
authors.affiliation: Department of Gastroenterology, Royal Children's Hospital, Melbourne, Victoria, Australia. jeremy.rosenbaum@rch.org.au
authors.forename: Jeremy
authors.initials: J
authors.lastname: Rosenbaum
authors.forename: John
authors.initials: J
authors.lastname: Vrazas
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Lane
authors.forename: Winita
authors.initials: W
authors.lastname: Hardikar
mesh_terms: D000293:Adolescent; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D016461:Chemoembolization, Therapeutic; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D008863:Microspheres; D009206:Myocardium / Q000473:pathology*; D014739:Victoria
chemical_list: D004317:Doxorubicin