title: Detailed exposure assessment of dietary furan for infants consuming commercially jarred complementary food based on data from the DONALD study.
abstract: Furan is a possible human carcinogen regularly occurring in commercially jarred complementary foods. This paper will provide a detailed exposure assessment for babies consuming these foods considering different intake scenarios. The occurrence data on furan in complementary foods were based on our own headspace-gas chromatography/mass spectrometry (HS-GC/MS) analytical results (n = 286). The average furan content in meals and menus was between 20 and 30 µg kg(-1), which is in excellent agreement with results from other European countries. Using measured food consumption data from the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study, the average exposures for consumers of commercially jarred foods ranged between 182 and 688 ng kg(-1) bw day(-1), with a worst case scenario for P95 consumers ranging between 351 and 1066 ng kg(-1) bw day(-1). The exposure data were then used to characterize risk using the margin of exposure method based on a benchmark dose lower confidence limit for a 10% response (BMDL10) of 1.28 mg kg(-1) bw day(-1) for hepatocellular tumours in rats. The margin of exposures (MOEs) were below the threshold of 10 000, which is often used to define public health risks, in all scenarios, ranging between 7022 and 1861 for average consumers and between 3642 and 1200 for the P95 consumers. Mitigative measures to avoid furan in complementary foods should be of high priority for risk management.
authors.affiliation: Chemisches und Veterinäruntersuchungsamt Karlsruhe, Karlsruhe, Germany. lachenmeier@web.de
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Lachenmeier
authors.forename: Elena
authors.initials: E
authors.lastname: Maser
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuballa
authors.forename: Helmut
authors.initials: H
authors.lastname: Reusch
authors.forename: Mathilde
authors.initials: M
authors.lastname: Kersting
authors.forename: Ute
authors.initials: U
authors.lastname: Alexy
mesh_terms: D001835:Body Weight; D002273:Carcinogens / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D005519:Food Preservation / Q000379:methods; D057141:Food, Preserved / Q000032:analysis*; D005663:Furans / Q000008:administration & dosage*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis*; D018570:Risk Assessment
chemical_list: D002273:Carcinogens; D005663:Furans; C039281:furan