title: Preparation of luminescent and mesoporous Eu3+/Tb3+ doped calcium silicate microspheres as drug carriers via a template route.
abstract: Luminescent and mesoporous Eu(3+)/Tb(3+) doped calcium silicate microspheres (LMCS) were synthesized by using mesoporous silica spheres as the templates. The LMCS and drug-loaded samples were characterized by means of X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), N(2) adsorption/desorption, and photoluminescence (PL) spectra. The results reveal that the LMCS have uniform spherical morphology with a diameter around 400 nm and the mesopore size of 6 nm. The prepared samples exhibit little cytotoxicity at concentrations below 5 mg mL(-1) via MTT assay. In addition, drug storage/release properties of the LMCS were demonstrated for ibuprofen (IBU). The obtained LMCS can be used to encapsulate drugs and release them. Under excitation by UV light, the IBU-loaded samples still show the characteristic (5)D(0)-(7)F(1-3) emission lines of Eu(3+) and the characteristic (5)D(4)-(7)F(3-6) emission lines of Tb(3+). The PL intensity of Eu(3+) in the drug carrier system increases with the cumulative released amount of IBU, making the drug release able to be tracked or monitored by the change of luminescence of Eu(3+). The LMCS reported here with mesoporous structure, good biocompatibility and luminescent property can be a promising drug delivery carrier.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Kang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Huang
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
authors.forename: Ping'an
authors.initials: P
authors.lastname: Ma
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000327:Adsorption; D000818:Animals; D017610:Calcium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D005063:Europium / Q000737:chemistry / Q000633:toxicity; D007052:Ibuprofen / Q000737:chemistry; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D016062:Porosity; D017640:Silicates / Q000138:chemical synthesis* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013725:Terbium / Q000737:chemistry / Q000633:toxicity; D013818:Thermogravimetry; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D017610:Calcium Compounds; D004337:Drug Carriers; D049408:Luminescent Agents; D017640:Silicates; D013725:Terbium; D005063:Europium; C031293:calcium silicate; D007052:Ibuprofen