title: Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics.
abstract: The present article summarizes the discussions of the 3rd European Science Foundation-University of Barcelona (ESF-UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain. It was focused on practical applications in routine medical practice. We provide practical recommendations for ten different clinical situations, that have either been approved or not approved by regulatory agencies. We propose some comments that might accompany the results of these tests, indicating the best drug and doses to be prescribed. The discussed examples include KRAS, cetuximab, panitumumab, EGFR-gefitinib, CYP2D6-tamoxifen, TPMT-azathioprine-6-mercaptopurine, VKORC1/CYP2C9-warfarin, CYP2C19-clopidogrel, HLA-B*5701-abacavir, HLA-B*5701-flucloxacillin, SLCO1B1-statins and CYP3A5-tacrolimus. We hope that these practical recommendations will help physicians, biologists, scientists and other healthcare professionals to prescribe, perform and interpret these genetic tests.
authors.affiliation: Univ Paris-Sud, Faculty of Medicine Paris-Sud, Pharmacology Department, Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin Bicêtre, France. laurent.becquemont@bct.aphp.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
authors.forename: Ana
authors.initials: A
authors.lastname: Alfirevic
authors.forename: Ursula
authors.initials: U
authors.lastname: Amstutz
authors.forename: Hiltrud
authors.initials: H
authors.lastname: Brauch
authors.forename: Evelyne
authors.initials: E
authors.lastname: Jacqz-Aigrain
authors.forename: Pierre
authors.initials: P
authors.lastname: Laurent-Puig
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Molina
authors.forename: Mikko
authors.initials: M
authors.lastname: Niemi
authors.forename: Matthias
authors.initials: M
authors.lastname: Schwab
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Somogyi
authors.forename: Eric
authors.initials: E
authors.lastname: Thervet
authors.forename: Anke-Hilse
authors.initials: AH
authors.lastname: Maitland-van der Zee
authors.forename: André Bp
authors.initials: AB
authors.lastname: van Kuilenburg
authors.forename: Ron Hn
authors.initials: RH
authors.lastname: van Schaik
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
authors.forename: Mia
authors.initials: M
authors.lastname: Wadelius
authors.forename: Ann K
authors.initials: AK
authors.lastname: Daly
mesh_terms: D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*; D017410:Practice Guidelines as Topic; D057285:Precision Medicine / Q000379:methods*; D055553:Prescription Drugs / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D055553:Prescription Drugs