title: Influence of two-component signal transduction systems of Lactobacillus casei BL23 on tolerance to stress conditions.
abstract: Lactobacillus casei BL23 carries 17 two-component signal transduction systems. Insertional mutations were introduced into each gene encoding the cognate response regulators, and their effects on growth under different conditions were assayed. Inactivation of systems TC01, TC06, and TC12 (LCABL_02080-LCABL_02090, LCABL_12050-LCABL_12060, and LCABL_19600-LCABL_19610, respectively) led to major growth defects under the conditions assayed.
authors.affiliation: Departamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas, P.O. Box 73, 46100 Burjassot, Valencia, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Alcántara
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Revilla-Guarinos
authors.forename: Manuel
authors.initials: M
authors.lastname: Zúñiga
mesh_terms: D004361:Drug Tolerance / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D007218:Industrial Microbiology; D007780:Lacticaseibacillus casei / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D016254:Mutagenesis, Insertional; D015398:Signal Transduction / Q000235:genetics*; D013312:Stress, Physiological / Q000235:genetics*