title: [Epidemiological surveillance of leptospirosis on Reunion Island in 2004-2008: possible impact of Chikungunya infection on the case fatality rate of leptospirosis].
abstract: In 2006, increased mortality due to leptospirosis in Reunion Island had alerted the authorities and justified the conduct of this study in order to update knowledge on the epidemiology of leptospirosis, whereas the latest epidemiological data published on the disease dated back to 2003. This study followed the scheme of a descriptive retrospective survey based on data from reporting and investigation of hospitalized cases of leptospirosis that occurred in Reunion between the 1st January 2004 and 31st December 2008. Data from the National Reference Center (NRC) have also been used. The annual number of reported cases (40 to 50) was stable over the period, which contrasted with the historical decreasing trend of incidence reported by the NRC. The circumstances of exposure were those usually associated with the disease on the island: about 80% of cases were infected between January and June, during the wet season; the main exposure factor identified was the practice of agriculture, declared or not; Leptospira icterohaemorrhagiae remained the most frequently isolated serovar, although regressing. Finally, our study has shown that excess mortality observed in 2006 did not result from an increased incidence but from a rise in the case fatality rate. This could be linked to the outbreak of chikungunya, which peaked in February 2006. In endemic areas of leptospirosis, health professionals should remain aware of the risk of occurrence of fatal cases during arbovirosis outbreaks.
authors.affiliation: Cellule de l'Institut de Veille Sanitaire en Région Océan Indien, 2 bis, avenue Georges-Brassens, F-97400, Saint-Denis (Réunion), France. philippe.renault@ars.sante.fr
authors.forename: P
authors.initials: P
authors.lastname: Renault
authors.forename: E
authors.initials: E
authors.lastname: Boidin
authors.forename: E
authors.initials: E
authors.lastname: D'Ortenzio
authors.forename: E
authors.initials: E
authors.lastname: Balleydier
authors.forename: B
authors.initials: B
authors.lastname: Daniel
authors.forename: L
authors.initials: L
authors.lastname: Filleul
mesh_terms: D000328:Adult; D018354:Alphavirus Infections / Q000401:mortality*; D002423:Cause of Death; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000276:immunology; D015897:Comorbidity; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006306:Health Surveys; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D041383:Leptospira interrogans serovar icterohaemorrhagiae / Q000276:immunology / Q000302:isolation & purification; D007922:Leptospirosis / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D012189:Retrospective Studies; D017508:Reunion / Q000453:epidemiology; D055815:Young Adult
chemical_list: D007075:Immunoglobulin M