title: Epigenetic mechanisms in inflammation.
abstract: Epigenetic modifications occur in response to environmental changes and play a fundamental role in gene expression following environmental stimuli. Major epigenetic events include methylation and acetylation of histones and regulatory factors, DNA methylation, and small non-coding RNAs. Diet, pollution, infections, and other environmental factors have profound effects on epigenetic modifications and trigger susceptibility to diseases. Despite a growing body of literature addressing the role of the environment on gene expression, very little is known about the epigenetic pathways involved in the modulation of inflammatory and anti-inflammatory genes. This review summarizes the current knowledge about epigenetic control mechanisms during the inflammatory response.
authors.affiliation: Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, School of Dentistry, University of Connecticut Health Center, 262 Farmington Avenue, Farmington, CT 06030, USA. dashzeveg@uchc.edu
authors.forename: D
authors.initials: D
authors.lastname: Bayarsaihan
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019175:DNA Methylation; D004777:Environment; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D006657:Histones / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics
chemical_list: D006657:Histones; D035683:MicroRNAs