title: KSRP, many functions for a single protein.
abstract: KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of post-translational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.
authors.affiliation: Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Briata
authors.forename: Ching-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Matteo
authors.initials: M
authors.lastname: Giovarelli
authors.forename: Michela
authors.initials: M
authors.lastname: Pasero
authors.forename: Michele
authors.initials: M
authors.lastname: Trabucchi
authors.forename: Andres
authors.initials: A
authors.lastname: Ramos
authors.forename: Roberto
authors.initials: R
authors.lastname: Gherzi
mesh_terms: D000818:Animals; D001483:Base Sequence; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*
chemical_list: C105789:KHSRP protein, human; D035683:MicroRNAs; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators