title: Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies?
abstract: The Pregenesys Consensus Meeting held in Cambridge on 13 July 2009 was organized by the Pregenesys Consortium to review and critically discuss current knowledge regarding early markers of preeclampsia, to identify priorities and opportunities for future research, to consider issues that may need to be addressed in future recommendations and to highlight key issues in cost effectiveness and national policies concerning prediction and early screening for the risk of developing preeclampsia. This report summarizes the outcome of the Consensus Meeting and draws attention to issues for further investigation with specific regard to single versus multiple markers, early versus late risk identification, and the long-term effects on both maternal and perinatal health and the need to include these in any future cost-benefit assessment.
authors.affiliation: Unit of Obstetrics and Gynaecology, Department of Clinical Sciences, L. Sacco and Centre for Fetal Research Giorgio Pardi, University of Milan, 20157 Milano, Italy. irene.cetin@unimi.it
authors.forename: I
authors.initials: I
authors.lastname: Cetin
authors.forename: B
authors.initials: B
authors.lastname: Huppertz
authors.forename: G
authors.initials: G
authors.lastname: Burton
authors.forename: H
authors.initials: H
authors.lastname: Cuckle
authors.forename: R
authors.initials: R
authors.lastname: Gonen
authors.forename: O
authors.initials: O
authors.lastname: Lapaire
authors.forename: L
authors.initials: L
authors.lastname: Mandia
authors.forename: K
authors.initials: K
authors.lastname: Nicolaides
authors.forename: C
authors.initials: C
authors.lastname: Redman
authors.forename: P
authors.initials: P
authors.lastname: Soothill
authors.forename: K
authors.initials: K
authors.lastname: Spencer
authors.forename: B
authors.initials: B
authors.lastname: Thilaganathan
authors.forename: D
authors.initials: D
authors.lastname: Williams
authors.forename: H
authors.initials: H
authors.lastname: Meiri
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D032921:Consensus; D003245:Consensus Statements as Topic; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D003944:Diagnostic Techniques, Obstetrical and Gynecological / Q000191:economics; D042241:Early Diagnosis; D005260:Female; D006287:Health Planning Guidelines; D006801:Humans; D008954:Models, Biological; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000191:economics / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D011315:Preventive Medicine / Q000191:economics / Q000379:methods*; D018570:Risk Assessment; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology / Q000502:physiology
chemical_list: D015415:Biomarkers