title: Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing.
abstract: Catalysed by members of the adenosine deaminase acting on RNA (ADAR) family of enzymes, adenosine-to-inosine (A-to-I) editing converts adenosines in RNA molecules to inosines, which are functionally equivalent to guanosines. Recently, global approaches to studying this widely conserved phenomenon have emerged. The use of bioinformatics, high-throughput sequencing and other approaches has increased the number of known editing sites by several orders of magnitude, and we now have a greater understanding of the control and the biological significance of editing. This Progress article reviews some of these recent global studies and their results.
authors.affiliation: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA. wulff@sas.upenn.edu
authors.forename: Bjorn-Erik
authors.initials: BE
authors.lastname: Wulff
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sakurai
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nishikura
mesh_terms: D000241:Adenosine / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007288:Inosine / Q000737:chemistry / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D017393:RNA Editing
chemical_list: D007288:Inosine; D012313:RNA; D000241:Adenosine