title: Tight junctions in cancer metastasis.
abstract: Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.
authors.affiliation: Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. martinta1@cf.ac.uk
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Martin
authors.forename: Malcolm D
authors.initials: MD
authors.lastname: Mason
authors.forename: Wen G
authors.initials: WG
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000503:physiopathology; D001943:Breast Neoplasms / Q000503:physiopathology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D057167:Claudins / Q000096:biosynthesis; D015179:Colorectal Neoplasms / Q000503:physiopathology; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D004848:Epithelium / Q000473:pathology; D004938:Esophageal Neoplasms / Q000503:physiopathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000503:physiopathology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007680:Kidney Neoplasms / Q000503:physiopathology; D008113:Liver Neoplasms / Q000503:physiopathology; D008175:Lung Neoplasms / Q000503:physiopathology; D008297:Male; D008545:Melanoma / Q000503:physiopathology; D008565:Membrane Proteins / Q000096:biosynthesis; D000075983:Nectins; D009361:Neoplasm Invasiveness / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D062793:Occludin; D010190:Pancreatic Neoplasms / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000503:physiopathology; D011956:Receptors, Cell Surface; D011991:Receptors, Virus / Q000096:biosynthesis; D013584:Sarcoma, Synovial / Q000503:physiopathology; D013274:Stomach Neoplasms / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000503:physiopathology; D019108:Tight Junctions / Q000502:physiology*; D001749:Urinary Bladder Neoplasms / Q000503:physiopathology
chemical_list: C568771:CLMP protein, human; D015815:Cell Adhesion Molecules; D057167:Claudins; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; C407243:F11R protein, human; D007136:Immunoglobulins; D008565:Membrane Proteins; D000075983:Nectins; C568985:OCLN protein, human; D062793:Occludin; D011956:Receptors, Cell Surface; D011991:Receptors, Virus