title: Growth hormone therapy and the risk of tumor recurrence after brain tumor treatment in children.
abstract: To assess the effect of human growth hormone (hGH) therapy and other factors on tumor recurrence after treatment of pediatric brain tumors (BTs), we retrospectively analyzed data from 108 craniopharyngioma, medulloblastoma, and ependymoma patients. Risk factors were identified using multifactorial univariate regression analysis. Recurrences occurred in 41 and second malignant neoplasms in 4 patients. There were significant correlations for completeness of tumor removal and recurrence-free survival (RFS). 13/44 hGH-treated and 28/59 non-hGH-treated children relapsed. This difference was found only for medulloblastomas and accounted for by higher rates of incomplete tumor removal in non-hGH patients. Craniopharyngioma recurrence correlated only with RFS. Malignant BT recurrence correlated with completeness of tumor removal, chemotherapy, and RFS. 4 children developed SMNs, 3/4 after hGH therapy. Our regression model yielded accurate within-sample prediction of recurrence for 90% of the study population. We conclude that hGH therapy after treatment of pediatric BTs does not increase tumor recurrence risk.
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Saarland University Hospital, Homburg/Saar, Germany.
authors.forename: Tilman R
authors.initials: TR
authors.lastname: Rohrer
authors.forename: Thorsten
authors.initials: T
authors.lastname: Langer
authors.forename: Gerhard G
authors.initials: GG
authors.lastname: Grabenbauer
authors.forename: Michael
authors.initials: M
authors.lastname: Buchfelder
authors.forename: Matthias
authors.initials: M
authors.lastname: Glowatzki
authors.forename: Helmuth G
authors.initials: HG
authors.lastname: Dörr
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D019382:Human Growth Hormone / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology; D012189:Retrospective Studies; D012306:Risk
chemical_list: D019382:Human Growth Hormone