title: A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.
abstract: Plasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a range of essential cellular processes, in particular Na(+)-dependent and proton-dependent secondary transport systems that are responsible for uptake and extrusion of metabolites and other ions. The ion gradients are also both directly and indirectly used to control pH homeostasis and to regulate cell volume. The plasma membrane H(+)-ATPase maintains a proton gradient in plants and fungi and the Na(+),K(+)-ATPase maintains a Na(+) and K(+) gradient in animal cells. Structural information provides insight into the function of these two distinct but related P-type pumps.
authors.affiliation: Danish National Research Foundation, Centre for Membrane Pumps in Cells and Disease - PUMPKIN, Denmark.
authors.forename: J Preben
authors.initials: JP
authors.lastname: Morth
authors.forename: Bjørn P
authors.initials: BP
authors.lastname: Pedersen
authors.forename: Morten J
authors.initials: MJ
authors.lastname: Buch-Pedersen
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Andersen
authors.forename: Bente
authors.initials: B
authors.lastname: Vilsen
authors.forename: Michael G
authors.initials: MG
authors.lastname: Palmgren
authors.forename: Poul
authors.initials: P
authors.lastname: Nissen
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006180:Proton-Translocating ATPases / Q000737:chemistry* / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D006180:Proton-Translocating ATPases; D000254:Sodium-Potassium-Exchanging ATPase