title: Epidermodysplasia verruciformis and susceptibility to HPV.
abstract: Epidermodysplasia verruciformis has been addressed in depth in the recent literature despite its rarity. The disease is characterized by a persistence in human papillomavirus infections and development of cutaneous malignancies, usually happening more frequently and at a younger age than in the general population. Because of the role of immunodeficiency to viral antigens eventually leading to cancer, EV has become a model for understanding a viral role in cutaneous oncogenesis. Susceptibility loci for EV have been mapped and encoded protein functions are becoming better understood. Discoveries of novel mutations and further study of EV-associated HPV serotypes in lesional and nonlesional skin of affected patients and the general population may help generate a cohesive theory regarding the true role of a defective immune barrier in oncogenesis.
authors.affiliation: Center for Clinical Studies, University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Tejas
authors.initials: T
authors.lastname: Patel
authors.forename: L Katie
authors.initials: LK
authors.lastname: Morrison
authors.forename: Peter
authors.initials: P
authors.lastname: Rady
authors.forename: Stephen
authors.initials: S
authors.lastname: Tyring
mesh_terms: D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D004819:Epidermodysplasia Verruciformis / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D027383:Papillomaviridae / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D015032:Zinc / Q000378:metabolism
chemical_list: D004279:DNA, Viral; D008565:Membrane Proteins; C470314:TMC6 protein, human; C470315:TMC8 protein, human; D015032:Zinc