title: The contribution of lower vertebrate animal models in human reproduction research.
abstract: Many advances have been carried out on the estrogens, GnRH and endocannabinoid system that have impact in the reproductive field. Indeed, estrogens, the generally accepted female hormones, have performed an unsuspected role in male sexual functions thanks to studies on non-mammalian vertebrates. Similarly, these animal models have provided important contributions to the identification of several GnRH ligand and receptor variants and their possible involvement in sexual behavior and gonadal function regulation. Moreover, the use of non-mammalian animal models has contributed to a better comprehension about the endocannabinoid system action in several mammalian reproductive events. We wish to highlight here how non-mammalian vertebrate animal model research contributes to advancements with implications on human health as well as providing a phylogenetic perspective on the evolution of reproductive systems in vertebrates.
authors.affiliation: Dipartimento di Medicina Sperimentale, Seconda Università degli Studi di Napoli, via Costantinopoli 16, 80138 Napoli, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Chianese
authors.forename: Teresa
authors.initials: T
authors.lastname: Chioccarelli
authors.forename: Giovanna
authors.initials: G
authors.lastname: Cacciola
authors.forename: Vincenza
authors.initials: V
authors.lastname: Ciaramella
authors.forename: Silvia
authors.initials: S
authors.lastname: Fasano
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pierantoni
authors.forename: Rosaria
authors.initials: R
authors.lastname: Meccariello
authors.forename: Gilda
authors.initials: G
authors.lastname: Cobellis
mesh_terms: D000818:Animals; D005075:Biological Evolution; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D023421:Models, Animal; D012098:Reproduction / Q000502:physiology*; D014714:Vertebrates
chemical_list: D063385:Cannabinoid Receptor Modulators; D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone