title: [Multidrug resistance of tumor/progenitor stem cells-- review].
abstract: Tumor Stem/Progenitor Cells are characterized by undifferentiation/hypodifferention, self-renewal, differentiation potential, which is responsible for tumor occurrence, growth and metastasis. The theory about tumor stem/progenitor cells provides a new insight to recognize the origin and essence of tumors. Gaining a better insight into the origin of tumor stem/progenitor cells and the mechanisms of tumor stem/progenitor cells resistance to chemotherapy may lead to new therapeutic targets and better anticancer strategies. This review summarizes recent progress of research on the origin of tumor stem/progenitor cells and multidrug resistance.
authors.affiliation: Department of Hematology, Southeast University Medical College, Nanjing 210009, Jiangsu Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D013234:Stem Cells / Q000187:drug effects*