title: An approach to the bis-oxazole macrocycle of diazonamides.
abstract: A convergent approach to a macrocyclic compound embodying the complete "eastern" quadrant of diazonamides is described. The opening sequence in this work relies on an oxazole-forming reaction devised earlier in this group, while a late step involves a Robinson-Gabriel cyclization of an amidoketone to form a second oxazole.
authors.affiliation: Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhang
authors.forename: Marco A
authors.initials: MA
authors.lastname: Ciufolini
mesh_terms: D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D047028:Macrocyclic Compounds; D010080:Oxazoles; C556380:diazonamide B