title: Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone.
abstract: Highly efficient preparations of anticancer β-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3-5 steps with excellent overall yields (43-54%). An enantioselective approach to these molecules is also described.
authors.affiliation: Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avda Fuente Nueva, s/n, 18071 Granada, Spain. afbarre@ugr.es
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Barrero
authors.forename: M Mar
authors.initials: MM
authors.lastname: Herrador
authors.forename: José F
authors.initials: JF
authors.lastname: Quílez del Moral
authors.forename: Pilar
authors.initials: P
authors.lastname: Arteaga
authors.forename: Niklas
authors.initials: N
authors.lastname: Meine
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Pérez-Morales
authors.forename: Julieta V
authors.initials: JV
authors.lastname: Catalán
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C445979:beta-elemene; D010165:Palladium; C048393:germacrone