title: Pulmonary manifestations of Sjögren's syndrome.
abstract: Sjögren's syndrome is a chronic inflammatory disorder characterized by lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary glands. However, extraglandular organ systems may frequently be involved, including the lungs. Although subclinical pulmonary inflammation exists in more than 50% of patients, clinically significant pulmonary involvement affects approximately 10% of patients and may be the first manifestation of the disease. The entire respiratory tract may be involved, with a wide spectrum of manifestations including xerotrachea and bronchial sicca, obstructive small airway disease, various patterns of interstitial lung disease, lymphoinfiltrative or lymphoproliferative lung disease, such as lymphoma (usually of MALT type), pulmonary hypertension, pleural involvement, lung cysts, and pulmonary amyloidosis.
authors.affiliation: Service de médecine interne, Centre national de référence des maladies systémiques et auto-immunes rares (sclérodermie), université Lille2, CHRU de Lille, place de Verdun, 59037 Lille, France. pyhatron@chru-lille.fr
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Hatron
authors.forename: Isabelle
authors.initials: I
authors.lastname: Tillie-Leblond
authors.forename: David
authors.initials: D
authors.lastname: Launay
authors.forename: Eric
authors.initials: E
authors.lastname: Hachulla
authors.forename: Anne Laure
authors.initials: AL
authors.lastname: Fauchais
authors.forename: Benoît
authors.initials: B
authors.lastname: Wallaert
mesh_terms: D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D017563:Lung Diseases, Interstitial / Q000209:etiology; D010995:Pleural Diseases / Q000209:etiology; D012859:Sjogren's Syndrome / Q000150:complications*