title: Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies.
abstract: The effect of a moderate, physiologically relevant rise in temperature on several neuroinflammatory parameters was investigated in vitro using human cell lines and cultured human astrocytes. A two degree Celsius rise in temperature was found to enhance the neurotoxicity of microglia-like and astrocytic cells, increase the release of monocyte chemotactic protein (MCP)-1 by activated human monocytic THP-1 cells and amplify the generation of reactive oxygen intermediates by differentiated HL-60 myelocytic cells. Moderate increases in body temperature may exacerbate neuroinflammation and neuronal injury in chronic neurodegenerative disorders. Hence, therapies aimed at lowering the body temperature could be used to slow down the progression of such diseases.
authors.affiliation: Department of Biology, University of British Columbia Okanagan, Kelowna, BC, Canada.
authors.forename: Manpreet
authors.initials: M
authors.lastname: Bahniwal
authors.forename: Erika B
authors.initials: EB
authors.lastname: Villanueva
authors.forename: Andis
authors.initials: A
authors.lastname: Klegeris
mesh_terms: D001831:Body Temperature / Q000276:immunology*; D001921:Brain / Q000276:immunology* / Q000473:pathology*; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D005334:Fever / Q000276:immunology* / Q000473:pathology; D018922:HL-60 Cells; D006801:Humans; D015213:Neuroimmunomodulation / Q000276:immunology*; D009474:Neurons / Q000276:immunology* / Q000473:pathology*