title: Effects of surfactant micelles on solubilization and DPPH radical scavenging activity of Rutin.
abstract: The interaction of the antioxidant Rutin with the radical DPPH (2,2-diphenyl-1-picrylhydrazyl) in presence of cationic (CTAB, TTAB, DTAB), non-ionic (Brij78, Brij58, Brij35), anionic (SDS) and mixed surfactant systems (CTAB-Brij58, DTAB-Brij35, SDS-Brij35) has been followed by spectrophotometric and tensiometric methods to evaluate the DPPH radical scavenging activity (RSA) of Rutin in these model self-assembled structures. The results show that the solubilization capacity of various single surfactant systems for both DPPH as well as Rutin followed the order cationics > non-ionics > anionic. The radical scavenging activity of Rutin in the solubilized form was higher within ionic micelles than in non-ionic micelles. However, the antioxidant exhibited enhanced activity for the radical in mixed cationic-non-ionic micelles compared with any of the single component micelles. In contrast, anionic-non-ionic mixed micelles modulated the activity of Rutin in-between that seen for pure anionic and non-ionic micelles only.
authors.affiliation: Department of Chemistry, University of Kashmir, Srinagar-190006, J&K, India.
authors.forename: Oyais Ahmad
authors.initials: OA
authors.lastname: Chat
authors.forename: Muzaffar Hussain
authors.initials: MH
authors.lastname: Najar
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Mir
authors.forename: Ghulam Mohammad
authors.initials: GM
authors.lastname: Rather
authors.forename: Aijaz Ahmad
authors.initials: AA
authors.lastname: Dar
mesh_terms: D000838:Anions / Q000737:chemistry; D001713:Biphenyl Compounds / Q000378:metabolism*; D002412:Cations / Q000737:chemistry; D016166:Free Radical Scavengers / Q000378:metabolism*; D008823:Micelles; D010851:Picrates / Q000378:metabolism*; D012431:Rutin / Q000378:metabolism*; D012995:Solubility; D013053:Spectrophotometry; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D000838:Anions; D001713:Biphenyl Compounds; D002412:Cations; D016166:Free Radical Scavengers; D008823:Micelles; D010851:Picrates; D013501:Surface-Active Agents; D012431:Rutin; C004931:1,1-diphenyl-2-picrylhydrazyl