title: The effect of diclofenac sodium on renal function in reversible unilateral ureteric obstruction.
abstract: The objective of the study was to investigate the effect of diclofenac sodium, when administered similar to its use in clinical practice, 2 weeks following different periods of complete reversible unilateral ureteric obstruction in the rat using accurate indicators of renal function. Male Wistar rats underwent reversible left ureteric obstruction for 2 days [D2-untreated (n = 8) and D2-DS (n = 8) groups] and 5 days [D5-untreated (n = 7) and D5-DS (n = 7) groups]. D2-DS and D5-DS received intramuscular diclofenac sodium (3 mg/kg per day) during the time of obstruction, whereas D2-untreated and D5-untreated groups did not receive any treatment. The renal functions of both kidneys were studied 2 weeks following the reversal. The basal heart rate and mean arterial blood pressure were similar in D2-untreated and D2-DS and in D5-untreated and D5-DS groups. In the D2-untreated group, the GFR and RBF of the left obstructed kidney were 76 and 72% that of the right non-obstructed kidney [0.99 ± 0.06 vs. 1.30 ± 0.08 (P < 0.05) and 4.25 ± 0.33 vs. 5.92 ± 0.61 (P < 0.05), respectively]. The urine volume and urinary and fractional sodium excretion were not significantly different from the right kidney. Similar response was obtained in the D2-DS group. In the D5-untreated group, the GFR and RBF of the left kidney was 66 and 62% that of the right kidney (0.80 ± 0.12 vs. 1.21 ± 0.6, P < 0.05 and 3.79 ± 0.32 vs. 6.16 ± 0.59, P < 0.05; respectively). The tubular functions of both kidneys were similar. In the D5-DS group, there was no difference in GFR or RBF between both kidneys (1.02 ± 0.08 vs. 1.12 ± 0.3, P = 0.24 and 5.10 ± 1.25 vs. 6.46 ± 1.11, P = 0.44, respectively). Similarly, there was no difference in the tubular functions. Treatment with diclofenac sodium during a relatively long period of reversible unilateral ureteric obstruction, similar to its use in the management of ureteric colic, appears to ameliorate the alterations in the hemodynamic glomerular functions at least 2 weeks following the reversal of obstruction.
authors.affiliation: Department of Surgery, Faculty of Medicine and Health Sciences, United Arab Emirates University, 17666 Al Ain, United Arab Emirates. fayez@mail2doctor.com
authors.forename: F T
authors.initials: FT
authors.lastname: Hammad
authors.forename: L
authors.initials: L
authors.lastname: Lubbad
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology*; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000098:blood supply / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D056844:Renal Colic / Q000188:drug therapy / Q000503:physiopathology; D014517:Ureteral Obstruction / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac