title: TLC for pharmaceutical analysis in resource limited countries.
abstract: This review article discusses the sustainability and robust advantages of planar chromatography that are critical to the successful performance of product quality assessments in resource limited areas including field applications. Because of the robustness and ease of use, the training required for successful performance of the high performance thin layer chromatography (HPTLC) assessments is much lower than that of other technologies with comparable reproducibility such as high performance liquid chromatography (HPLC). Some of the successful applications of planar chromatography in resource limited countries are presented. It should be noted that these planar chromatographic technologies have much lower plate counts and therefore separation power than column technologies such as HPLC and gas liquid chromatography (GLC). However in finished pharmaceutical products there are generally few active ingredients which are assessed making the HPTLC adequate for these analyses. In addition at this time there is a much wider array of detection technologies available for HPLC and GLC.
authors.affiliation: Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. elia.kaale@muhas.ac.tz
authors.forename: Eliangiringa
authors.initials: E
authors.lastname: Kaale
authors.forename: Peter
authors.initials: P
authors.lastname: Risha
authors.forename: Thomas
authors.initials: T
authors.lastname: Layloff
mesh_terms: D000349:Africa; D002851:Chromatography, High Pressure Liquid / Q000191:economics / Q000379:methods; D002855:Chromatography, Thin Layer / Q000191:economics* / Q000379:methods*; D003906:Developing Countries; D016903:Drug Monitoring / Q000191:economics / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results
chemical_list: D004364:Pharmaceutical Preparations