title: Translational research efforts in biomarkers and biology of early transplant-related complications.
abstract: In the time since the first allogeneic hematopoietic stem cell transplantation (HSCT) was performed over 40 years ago, this life-saving procedure has been used increasingly for patients with hematologic, metabolic, and malignant diseases. Despite major advances in our understanding of the immunologic processes (both beneficial and injurious) that are associated with HSCT and improvements in supportive and critical care medicine, successful outcomes are still limited by several serious complications. As such, the establishment of effective therapeutic strategies for these complications will be crucial as increasing numbers of high-risk transplants are performed each year. The development of such approaches is fundamentally dependent upon a basic understanding of pathophysiologic mechanisms of disease and also on our ability to successfully translate these insights back to the bedside. This brief review will highlight breakthroughs in translational research endeavors that have paved the way for the development of novel strategies intended to change the standard of care and optimize outcomes for patients in whom allogeneic HSCT offers the only hope for a cure.
authors.affiliation: Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA.
authors.forename: Sophie
authors.initials: S
authors.lastname: Paczesny
authors.forename: Maribel
authors.initials: M
authors.lastname: Diaz-Ricart
authors.forename: Enric
authors.initials: E
authors.lastname: Carreras
authors.forename: Enrique
authors.initials: E
authors.lastname: Carerras
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Cooke
mesh_terms: D015415:Biomarkers; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D006086:Graft vs Host Disease / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D040901:Proteomics / Q000379:methods; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D015415:Biomarkers