title: Clinical and pathological features of Riedel's thyroiditis.
abstract: OBJECTIVE
  To evaluate the clinical and pathological features of Riedel's thyroiditis (RT), and current diagnostic and treatment methods for that disease.
  
  
  METHODS
  Five RT cases identified by surgery and pathological examinations at Peking Union Medical College Hospital from 1985 to 2009 were analyzed and compared with the cases reported in the literature in terms of clinical and pathological features. Immunohistochemical staining of kappa and lambda light chains was carried out for RT tissues from all the five patients.
  
  
  RESULTS
  All the five cases were females, aged 45-55 years. Elevation of serum thyroid autoantibodies was found in only one patient, who had longer disease duration than the others. Pathological examination revealed invasive fibrosclerosis of the thyroid follicles, thyroid capsule, and the surrounding tissues. In RT tissues, the number of cells containing lambda chains was a little higher than those containing kappa chains.
  
  
  CONCLUSIONS
  RT is a rare disease which might be more common in middle-aged females than in other populations. Pathological features include the destruction of thyroid follicle, extension into surrounding tissues by inflammatory cells and fibrous tissues. Immunohistochemical staining of kappa and lambda chains could help diagnose RT.
authors.affiliation: Department of Endocrinology, Key Laboratory of Endocrine and Metabolic Diseases of Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Feng
authors.initials: F
authors.lastname: Gu
authors.forename: Wei-Xin
authors.initials: WX
authors.lastname: Dai
authors.forename: Wu-Yi
authors.initials: WY
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiao
authors.forename: Zheng-Pei
authors.initials: ZP
authors.lastname: Zeng
mesh_terms: D001323:Autoantibodies / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008861:Microsomes / Q000276:immunology; D008875:Middle Aged; D013965:Thyroidectomy; D013966:Thyroiditis / Q000276:immunology / Q000473:pathology* / Q000601:surgery
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin