title: Skin advanced glycation end product accumulation and muscle strength among adult men.
abstract: Aging is associated with decreased skeletal muscle function. Increased levels of advanced glycation end products (AGEs) in skeletal muscle tissue are observed with advancing age and in diabetes. Although serum AGE level is negatively associated with grip strength in elderly people, it is unknown whether this association is present in adult males. To determine the relationship between AGE accumulation in tissue and muscle strength and power among Japanese adult men. Skin autofluorescence (AF) (a noninvasive method for measuring tissue AGEs), grip strength (n = 232), and leg extension power (n = 138) were measured in Japanese adult men [median (interquartile range) age, 46.0 (37.0, 56.0) years]. After adjustment for potential confounders, the adjusted means [95% confidence interval (CI)] for grip strength across the tertiles of skin AF were 44.5 (43.2, 45.9) kg for the lowest tertile, 42.0 (40.6, 43.3) kg for the middle tertile, and 41.7 (40.3, 43.1) kg for the highest tertile (P for trend < 0.01). Moreover, the adjusted geometric means (95% CI) of leg extension power across the tertiles of skin AF were 17.8 (16.6, 19.1) W/kg for the lowest tertile, 17.5 (16.4, 18.7) W/kg for the middle tertile, and 16.0 (14.9, 17.1) W/kg for the highest tertile (P for trend = 0.04). Among Japanese adult men, participants with higher skin AF had lower muscle strength and power, indicating a relationship between AGE accumulation and muscle strength and power. A long-term prospective study is required to clarify the causality.
authors.affiliation: Department of Medicine and Science in Sports and Exercise, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Momma
authors.forename: Kaijun
authors.initials: K
authors.lastname: Niu
authors.forename: Yoritoshi
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Lei
authors.initials: L
authors.lastname: Guan
authors.forename: Mika
authors.initials: M
authors.lastname: Sato
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Masahiko
authors.initials: M
authors.lastname: Chujo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Otomo
authors.forename: Cui
authors.initials: C
authors.lastname: Yufei
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tadaura
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Saito
authors.forename: Takefumi
authors.initials: T
authors.lastname: Mori
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyata
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Nagatomi
mesh_terms: D000328:Adult; D000465:Algorithms; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D007866:Leg / Q000502:physiology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D016059:Range of Motion, Articular / Q000502:physiology; D012867:Skin / Q000378:metabolism*
chemical_list: D017127:Glycation End Products, Advanced