title: [Risk factors of early recurrence in patients with gastric cancer after curative resection].
abstract: OBJECTIVE
  To analyze the clinical and pathologic influencing factors of early recurrence in patents with gastric cancer after radical gastrectomy.
  
  
  METHODS
  Clinicopathological data of 141 patients with recurrence after curative gastrectomy for gastric cancer from January 2001 to December 2004 were analyzed retrospectively. Risk factors correlated with tumor early recurrence and survival difference between early recurrence group (< 1 year, 82 cases) and control group (1 year after, 59 cases) were assessed.
  
  
  RESULTS
  The 1- and 3-year survival rates of in early recurrence group and control group were 36.6%, 2.4% and 100%, 45.8%, respectively (P < 0.05). The median survival time after recurrence in the two groups was 3, 5 months, respectively (P < 0.05). Univariate analysis showed that the age, tumor Borrmann type, tumor site, invasive depth, lymph node metastasis, pTNM stage, metastatic lymph node ratio, surgical procedure and intraperitoneal hyperthermic perfusion chemotherapy (IHPC) were significant factors associated with early recurrence after curative gastrectomy for gastric cancer (P < 0.05). Lymph node metastasis, metastatic lymph node ratio and IHPC were independent factors associate with early recurrence after curative gastrectomy on multivariate analysis (P < 0.05).
  
  
  CONCLUSIONS
  The patients with early recurrence after the radical gastrectomy have a poorer survival compared with cases recur later. Lymph node metastasis, metastatic lymph node ratio and IHPC are independent factors associate with early recurrence after curative gastrectomy for gastric cancer.
authors.affiliation: Department of Gastrointestinal Cancer, Key Laboratory of Cancer Prevention and Treatment of Tianjin City, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China.
authors.forename: Liang-liang
authors.initials: LL
authors.lastname: Wu
authors.forename: Han
authors.initials: H
authors.lastname: Liang
authors.forename: Xiao-na
authors.initials: XN
authors.lastname: Wang
authors.forename: Ru-peng
authors.initials: RP
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Pan
authors.forename: Bao-gui
authors.initials: BG
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000473:pathology; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery