title: Solid phase strain promoted "click" modification of DNA via [3+2]-nitrile oxide-cyclooctyne cycloadditions.
abstract: Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctyne-nitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.
authors.affiliation: Department of Chemistry, National University of Ireland, Maynooth, Co. Kildare, Republic of Ireland. ishwar.singh@nuim.ie
authors.forename: Ishwar
authors.initials: I
authors.lastname: Singh
authors.forename: Frances
authors.initials: F
authors.lastname: Heaney
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D057930:Click Chemistry; D034242:Cyclooctanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry
chemical_list: D000480:Alkynes; D034242:Cyclooctanes; D009570:Nitriles; D010087:Oxides; D010091:Oximes; D004247:DNA