title: An atom-economic synthesis of nitrogen heterocycles from alkynes.
abstract: A robust route to 2,4-disubstituted pyrrole heterocycles relying upon a cascade reaction is reported. The reaction benefits from operational simplicity: it is air and moisture tolerant and is performed at ambient temperature. Control over the reaction conditions provides ready access to isopyrroles, 2,3,4-trisubstituted pyrroles, and 3-substituted pyrollidin-2-ones.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305-5080, United States. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Jean-Philip
authors.initials: JP
authors.lastname: Lumb
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Azzarelli
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D009584:Nitrogen / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000480:Alkynes; D011758:Pyrroles; D009584:Nitrogen