title: Estimating a mosquito repellent's potential to reduce malaria in communities.
abstract: OBJECTIVE
  Probability models for assessing a mosquito repellent's potential to reduce malaria transmission are not readily available to public health researchers. To provide a means for estimating the epidemiological efficacy of mosquito repellents in communities, we developed a simple mathematical model.
  
  
  METHODS
  A static probability model is presented to simulate malaria infection in a community during a single transmission season. The model includes five parameters- sporozoite rate, human infection rate, biting pressure, repellent efficacy, and product-acceptance rate.
  
  
  METHODS
  The model assumes that a certain percentage of the population uses a personal mosquito repellent over the course of a seven-month transmission season and that this repellent maintains a constant rate of protective efficacy against the bites of malaria vectors.
  
  
  METHODS
  This model measures the probability of evading infection in circumstances where vector biting pressure, repellent efficacy, and product acceptance may vary. [corrected]
  
  
  CONCLUSIONS
  Absolute protection using mosquito repellents alone requires high rates of repellent efficacy and product acceptance. [corrected] Using performance data from a highly effective repellent, the model estimates an 88.9% reduction of infections over a seven- month transmission season. A corresponding reduction in the incidence of super-infection in community members not completely evading infection can also be presumed. Thus, the model shows that mass distribution of a repellent with >98% efficacy and >98% product acceptance would suppress new malaria infections to levels lower than those achieved with insecticide treated nets (ITNs). A combination of both interventions could create synergies that result in reductions of disease burden significantly greater than with the use of ITNs alone.
authors.affiliation: Natural and Applied Sciences, Bentley University, Waltham, MA, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Kiszewski
authors.forename: S T
authors.initials: ST
authors.lastname: Darling
mesh_terms: D000818:Animals; D009033:Culicidae / Q000187:drug effects*; D006801:Humans; D007302:Insect Repellents / Q000494:pharmacology*; D008288:Malaria / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*; D008962:Models, Theoretical; D009032:Mosquito Control / Q000379:methods*; D012111:Residence Characteristics; D012423:Rural Health
chemical_list: D007302:Insect Repellents