title: Müllerian inhibiting substance is anterogradely transported and does not attenuate avulsion-induced death of hypoglossal motor neurons.
abstract: Müllerian Inhibiting Substance (MIS, Anti-Müllerian hormone) is a gonadal hormone that contributes to the subtle sex-biases in the nervous system. Mature neurons of both sexes also produce MIS, suggesting that MIS may be a paracrine regulator of adult neural networks. We report here that murine hypoglossal motor neurons produce MIS and its receptors, MISRII and bone morphogenetic protein receptor 1A (BMPR1A, ALK3), but differentially transport them, with only MIS being detectable in axons. The production of MIS and its receptors were rapidly down regulated after axonal damage, which is a characteristic of genes involved in mature neuronal function. MIS is a survival factor for embryonic spinal motor neurons, but the rate of cell loss after hypoglossal nerve avulsion was normal in Mis(-/-) mice and was not attenuated by intraventricular administration of MIS. These observations suggest that MIS may be involved in anterograde rather than autocrine or retrograde regulation of neurons.
authors.affiliation: Department of Anatomy and Structural Biology, University of Otago, PO Box 913, Dunedin 9054, New Zealand.
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Clarkson
authors.forename: Caroline L
authors.initials: CL
authors.lastname: Talbot
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Wang
authors.forename: David T
authors.initials: DT
authors.lastname: MacLaughlin
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Donahoe
authors.forename: Ian S
authors.initials: IS
authors.lastname: McLennan
mesh_terms: D000818:Animals; D054304:Anti-Mullerian Hormone / Q000378:metabolism*; D001369:Axons / Q000378:metabolism*; D052005:Bone Morphogenetic Protein Receptors, Type I / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D007002:Hypoglossal Nerve / Q000378:metabolism* / Q000473:pathology; D061228:Hypoglossal Nerve Injuries; D051379:Mice; D009046:Motor Neurons / Q000378:metabolism* / Q000473:pathology; D021381:Protein Transport / Q000502:physiology; D018000:Receptors, Peptide / Q000378:metabolism; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone; C498212:Bmpr1a protein, mouse; D052005:Bone Morphogenetic Protein Receptors, Type I