title: Brain natriuretic peptide rs198388 polymorphism and essential hypertension in Hunan Han people.
abstract: OBJECTIVE
  To investigate the relation between brain natriuretic peptide (BNP) rs198388 polymorphism and the susceptibility of essential hypertension in Han population of Hunan.
  
  
  METHODS
  A total of 567 patients with hypertension (the hypertension group) and 555 healthy volunteers (the control group) were enrolled. Gender, age, smoking and drinking history of the 2 groups were not significantly different. Blood pressure was measured in the 2 groups. After fasting for 12 h or more, blood glucose, total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured. DNA polymorphism analysis was done by polymerase chain reaction-restriction fragment length polymorphism method, and genotype was determined by agarose gel electrophoresis.
  
  
  RESULTS
  The GG, GA, and AA genotypes were detected.The frequencies of GA and AA genotypes and A allele were significantly lower in the hypertension group (GA and AA:12.3%;A:6.9%) than those in the control group (GA and AA:18.4%; A:9.7%; P=0.009, and P=0.014, respectively).
  
  
  CONCLUSIONS
  BNP rs198388 polymorphism may be associated with essential hypertension in Han people in Hunan. Carrying rs198388 GA and AA genotypes and A allele may be the reason for low risk of hypertension.
authors.affiliation: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.forename: Yijie
authors.initials: Y
authors.lastname: Guo
authors.forename: Ruizheng
authors.initials: R
authors.lastname: Shi
authors.forename: Guogang
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020097:Natriuretic Peptide, Brain / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D020097:Natriuretic Peptide, Brain