title: Anticancer active illudins: recent developments of a potent alkylating compound class.
abstract: An overview of anticancer active spirocyclopropanes of the illudin class is provided. After a short introduction on the history and general chemistry of illudins M and S, new discoveries concerning their mode of action and metabolism are reported as well as new synthetic endeavors towards derivatives with improved selectivity for and efficacy against cancer cells. In addition, common and recently tapped biological sources and isolation procedures for known and new illudins are discussed. Pertinent literature is covered up to 2010.
authors.affiliation: Organic Chemistry Laboratory, University of Bayreuth, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schobert
authors.forename: S
authors.initials: S
authors.lastname: Knauer
authors.forename: S
authors.initials: S
authors.lastname: Seibt
authors.forename: B
authors.initials: B
authors.lastname: Biersack
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000477:Alkylating Agents; D000970:Antineoplastic Agents; D013141:Spiro Compounds