title: Population expansion in the North African late Pleistocene signalled by mitochondrial DNA haplogroup U6.
abstract: BACKGROUND
  The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene.
  
  
  RESULTS
  Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East.
  
  
  CONCLUSIONS
  A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast.
authors.affiliation: Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Portugal. lpereira@ipatimup.pt
authors.forename: Luísa
authors.initials: L
authors.lastname: Pereira
authors.forename: Nuno M
authors.initials: NM
authors.lastname: Silva
authors.forename: Ricardo
authors.initials: R
authors.lastname: Franco-Duarte
authors.forename: Verónica
authors.initials: V
authors.lastname: Fernandes
authors.forename: Joana B
authors.initials: JB
authors.lastname: Pereira
authors.forename: Marta D
authors.initials: MD
authors.lastname: Costa
authors.forename: Haidé
authors.initials: H
authors.lastname: Martins
authors.forename: Pedro
authors.initials: P
authors.lastname: Soares
authors.forename: Doron M
authors.initials: DM
authors.lastname: Behar
authors.forename: Martin B
authors.initials: MB
authors.lastname: Richards
authors.forename: Vincent
authors.initials: V
authors.lastname: Macaulay
mesh_terms: D000352:Africa, Northern; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005060:Europe; D019143:Evolution, Molecular; D005828:Genetics, Population; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D016013:Likelihood Functions; D009154:Mutation; D010802:Phylogeny; D058974:Phylogeography; D012641:Selection, Genetic
chemical_list: D004272:DNA, Mitochondrial