title: Growth hormone, insulin like growth factor-1, and insulin-like growth factor-binding protein-3 levels in the neonatal period: a preliminary study.
abstract: BACKGROUND
  Growth hormone (GH), insulinlike growth factor-1 (IGF-1), and IGF-binding protein-3 (IGFBP-3) are used in the neonatal period for evaluation of diseases such as GH deficiency, intrauterine growth restriction, and hypoglycemia. However, GH level has been reported as a single value during the neonatal period. In this study, we attempted to determine the changes of GH, IGF-1, and IGFBP-3 in the neonatal period for each week.
  
  
  METHODS
  One hundred and two appropriate-for-gestational age (AGA) term neonates who did not have any diseases that would interfere with GH-IGF axis were included in this cross-sectional study. Blood samples were collected and serum GH, IGF-1 and IGFBP-3 levels were measured by immunoradiometric analysis (IRMA) and weekly values were obtained for the first postnatal four weeks.
  
  
  RESULTS
  We showed that GH level [median (1st-3rd quartile)] decreases from the first to the fourth postnatal week [25.1 (18.5-37.4); 17.2 (13.2-22.8); 17.6 (12.2-20.2); 14.4 (6.60-19.8) ng/mL, respectively)], IGF-1 and IGFBP-3 levels [median (lst-3rd quartile)] increase [41.7 (18.0-70.0); 55.9 (39.0-103); 53.0 (40.0-97.7); 71.7 (44.3-137) and 1852 (1597-2451); 2430 (1645-2838); 2841 (2280-3675); 3018 (2151-4189) ng/mL, respectively)].
  
  
  CONCLUSIONS
  GH, IGF-1 and IGFBP-3 values can be evaluated for each week separately instead of for the entire neonatal period.
authors.affiliation: Department of Pediatrics, Erciyes University School of Medicine, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
authors.forename: Meda
authors.initials: M
authors.lastname: Kondolot
authors.forename: Mümtaz M
authors.initials: MM
authors.lastname: Mazicioğlu
authors.forename: Nihal
authors.initials: N
authors.lastname: Hatipoğlu
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Akin
authors.forename: Başak
authors.initials: B
authors.lastname: Akyildiz
mesh_terms: D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I