title: Population-specific documentation of pharmacogenomic markers and their allelic frequencies in FINDbase.
abstract: OBJECTIVE
  Population and ethnic group-specific allele frequencies of pharmacogenomic markers are poorly documented and not systematically collected in structured data repositories. We developed the Frequency of Inherited Disorders Pharmacogenomics database (FINDbase-PGx), a separate module of the FINDbase, aiming to systematically document pharmacogenomic allele frequencies in various populations and ethnic groups worldwide.
  
  
  METHODS
  We critically collected and curated 214 scientific articles reporting pharmacogenomic markers allele frequencies in various populations and ethnic groups worldwide. Subsequently, in order to host the curated data, support data visualization and data mining, we developed a website application, utilizing Microsoft™ PivotViewer software.
  
  
  RESULTS
  Curated allelic frequency data pertaining to 144 pharmacogenomic markers across 14 genes, representing approximately 87,000 individuals from 150 populations worldwide, are currently included in FINDbase-PGx. A user-friendly query interface allows for easy data querying, based on numerous content criteria, such as population, ethnic group, geographical region, gene, drug and rare allele frequency.
  
  
  CONCLUSIONS
  FINDbase-PGx is a comprehensive database, which, unlike other pharmacogenomic knowledgebases, fulfills the much needed requirement to systematically document pharmacogenomic allelic frequencies in various populations and ethnic groups worldwide.
authors.affiliation: Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
authors.forename: Marianthi
authors.initials: M
authors.lastname: Georgitsi
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Viennas
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Gkantouna
authors.forename: Elena
authors.initials: E
authors.lastname: Christodoulopoulou
authors.forename: Zoi
authors.initials: Z
authors.lastname: Zagoriti
authors.forename: Christina
authors.initials: C
authors.lastname: Tafrali
authors.forename: Fotios
authors.initials: F
authors.lastname: Ntellos
authors.forename: Olga
authors.initials: O
authors.lastname: Giannakopoulou
authors.forename: Athanassia
authors.initials: A
authors.lastname: Boulakou
authors.forename: Panagiota
authors.initials: P
authors.lastname: Vlahopoulou
authors.forename: Eva
authors.initials: E
authors.lastname: Kyriacou
authors.forename: John
authors.initials: J
authors.lastname: Tsaknakis
authors.forename: Athanassios
authors.initials: A
authors.lastname: Tsakalidis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Poulas
authors.forename: Giannis
authors.initials: G
authors.lastname: Tzimas
authors.forename: George P
authors.initials: GP
authors.lastname: Patrinos
mesh_terms: D030541:Databases, Genetic; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D010597:Pharmacogenetics; D014584:User-Computer Interface
chemical_list: D005819:Genetic Markers