title: Fluoroquinolone-resistant Streptococcus agalactiae isolates from Argentina.
abstract: Fluoroquinolone resistance is a growing problem that has only recently emerged in S. agalactiae. Between 2005-2007, WHONET--Argentina network evaluated levofloxacin susceptibility in 1128 clinical S. agalactiae isolates, 10 (0.9%) of which proved to be resistant. Nine of them had come from 5 hospitals (in Buenos Aires City and 4 Argentinean provinces) and recovered from urine (n=7) and vaginal screening cultures (n=2). Three strains were also resistant to macrolides, lincosamides and B streptogramins due to the ermA gene. All nine fluoroquinolone-resistant isolates bore the same two mutations, Ser79Phe in ParC and Ser81Leu in GyrA proteins. Genetic relationships were analyzed by Apal-PFGE and two clones were determined, A (n=6) and B (n=3). To our knowledge, these are the first fluoroquinolone-resistant S. agalactiae isolates detected in Latin America.
authors.affiliation: Senrvicio Antimicrobianos, INEI-ANLIS Dr. Carlos G. Malbran, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: D
authors.initials: D
authors.lastname: Faccone
authors.forename: L
authors.initials: L
authors.lastname: Guerriero
authors.forename: E
authors.initials: E
authors.lastname: Méndez
authors.forename: L
authors.initials: L
authors.lastname: Errecalde
authors.forename: H
authors.initials: H
authors.lastname: Cano
authors.forename: N
authors.initials: N
authors.lastname: Yoyas
authors.forename: A
authors.initials: A
authors.lastname: Togneri
authors.forename: V
authors.initials: V
authors.lastname: Romanowski
authors.forename: M
authors.initials: M
authors.lastname: Galas
authors.forename: Red
authors.initials: R
authors.lastname: Whonet
authors.forename: A
authors.initials: A
authors.lastname: Corso
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001118:Argentina; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones