title: A positive correlation between hydrogen peroxide and soluble TNF-alpha receptor 2 early in maternal blood and at term in placenta of pregnant women with preeclampsia.
abstract: OBJECTIVE
  We hypothesized that hydrogen peroxide (H(2)O(2)) and soluble TNF-α receptor 2 (sTNF-R2) co-play a role in the pathogenesis of preeclampsia.
  
  
  METHODS
  Correlation of H(2)O(2) and sTNF-R2 was assessed in vivo in maternal blood and placenta, and in vitro in cytotrophoblasts culture.
  
  
  RESULTS
  We showed a positive correlation between increased levels of H(2)O(2) and sTNF-R2 early at 10-15 gestational weeks and at term in maternal serum, and in placenta of women with preeclampsia. Our in vitro experiments showed that H(2)O(2) induced the placental synthesis of sTNF-R2.
  
  
  CONCLUSIONS
  We propose to consider H(2)O(2) and sTNF-R2 as potential biomarkers in predicting preeclampsia.
authors.affiliation: Department of Obstetrics-Gynecology, Sherbrooke University Hospital Centre, Sherbrooke, QC, Canada.
authors.forename: Samuel
authors.initials: S
authors.lastname: Leblanc
authors.forename: Annie
authors.initials: A
authors.lastname: Ouellet
authors.forename: Yves
authors.initials: Y
authors.lastname: Giguère
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Forest
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Moutquin
authors.forename: Aziz
authors.initials: A
authors.lastname: Aris
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D047889:Receptors, Tumor Necrosis Factor, Type II; D006861:Hydrogen Peroxide