title: The redox state of albumin and serious cardiovascular incidence in hemodialysis patients.
abstract: Human serum albumin is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing powers and oxidized human non-mercaptoalbumin. The aim of this study is to clarify whether such redox state of albumin (HSA-redox) influences the incidence of cardiovascular disease (CVD) in chronic kidney disease patients on regular hemodialysis (HD). We measured HSA-redox using high-performance liquid chromatography in 86 anuric HD patients. The association between HSA-redox and incidental CVD events was evaluated. Twenty patients experienced symptomatic CVD events (16 patients died) at the 2-year follow-up. The fraction of HMA (f(HMA)) showed a significantly lower value in patients with CVD than that without CVD, in both pre-HD (36.5 ± 5.8% and 44.6 ± 9.8%, respectively) and post-HD (57.2 ± 6.2% and 67.2 ± 7.4%, respectively). The adjusted odds ratio (OR) for the incidental CVD event in patients with pre-HD f(HMA) < 40% was 5.0 (95% CI; 1.2 to 21.3), and that in patients with post-HD f(HMA) < 60% was 20.6 (3.2 to 134.7). Likewise, the adjusted OR for the CVD death in patients with pre-HD f(HMA) < 40% was 2.5 (0.6 to 12.5), and that in patients with post-HD f(HMA) < 60% was 25.6 (2.5 to 262.8). In conclusion, HSA-redox is closely related to serious CVD incidence and mortality among HD patients.
authors.affiliation: Division of Kidney and Hypertension, The Jikei University School of Medicine, Tokyo, Japan. terawaki@jikei.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Terawaki
authors.forename: Yukie
authors.initials: Y
authors.lastname: Takada
authors.forename: Seiichi
authors.initials: S
authors.lastname: Era
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Funakoshi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakayama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakayama
authors.forename: Makoto
authors.initials: M
authors.lastname: Ogura
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Ito
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D002851:Chromatography, High Pressure Liquid; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011446:Prospective Studies; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin