title: Biomimetic dentin desensitizer based on nano-structured bioactive glass.
abstract: OBJECTIVE
  This study evaluated the ability of a novel sol-gel bioactive glass, in conjunction with appropriate carrier vehicles, to reduce dentinal fluid flow, with an eye toward reducing dentinal hypersensitivity.
  
  
  METHODS
  Experiments were conducted to measure the reduction in tubule fluid flow after treatment of cut tooth surfaces with sol-gel bioactive glass particles in several carrier vehicles. Surfaces were also examined after exposure to brushing and acidic solutions. A non-bioactive particulate glass was compared.
  
  
  RESULTS
  Tubular occlusion produced by the bioactive glass was observed via SEM and a sustained reduction in hydrodynamic conductance was measured after exposure to various fluids and brushing.
  
  
  CONCLUSIONS
  This new material may be used with the tested carriers to significantly and durably reduce tubule fluid flow, ultimately resulting in reduced dentinal hypersensitivity.
authors.affiliation: Department of Restorative Dentistry, Division of Biomaterials and Biomechanics, Oregon Health & Science University, 611 SW Campus Drive, Portland, OR 97239, United States. mitchelj@ohsu.edu
authors.forename: John C
authors.initials: JC
authors.lastname: Mitchell
authors.forename: Lawrence
authors.initials: L
authors.lastname: Musanje
authors.forename: Jack L
authors.initials: JL
authors.lastname: Ferracane
mesh_terms: D000143:Acids; D001628:Beverages; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D040761:Biomimetic Materials / Q000737:chemistry / Q000627:therapeutic use*; D002253:Carbonated Beverages; D032083:Citrus paradisi; D003069:Coffee; D003804:Dentin / Q000187:drug effects / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D019234:Dentinal Fluid / Q000187:drug effects; D004337:Drug Carriers / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage; D005898:Glass / Q000737:chemistry; D005990:Glycerol / Q000008:administration & dosage; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000008:administration & dosage; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use*; D044367:Phase Transition; D019946:Propylene Glycol / Q000008:administration & dosage; D012212:Rheology; D012822:Silicon Dioxide / Q000627:therapeutic use; D012997:Solvents / Q000008:administration & dosage; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014099:Toothbrushing
chemical_list: D000143:Acids; D001672:Biocompatible Materials; D003069:Coffee; D057133:Dentin Desensitizing Agents; D004337:Drug Carriers; D008689:Methacrylates; D012997:Solvents; C448994:bioactive glass 58S; D000431:Ethanol; D019946:Propylene Glycol; C005044:hydroxyethyl methacrylate; D012822:Silicon Dioxide; D005990:Glycerol