title: Hypocomplementemic urticarial vasculitis in mixed connective tissue disease.
abstract: Urticarial vasculitis is characterized clinically by urticaria-like skin lesions and histologically by leukocytoclastic vasculitis. It may be idiopathic or associated with various conditions such as infections, hematologic disorders, drugs, and connective tissue diseases, primarily systemic lupus erythematosus; an association with mixed connective tissue disease (MCTD) has rarely been reported. We present a case of hypocomplementemic urticarial vasculitis in a patient with MCTD that responded to hydroxychloroquine after a period of corticosteroid dependence.
authors.affiliation: Department of Dermatology and Venereology, Hospital São João, Porto, Portugal.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Calistru
authors.forename: Carmen
authors.initials: C
authors.lastname: Lisboa
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Cruz
authors.forename: Luis
authors.initials: L
authors.lastname: Delgado
authors.forename: Licínio
authors.initials: L
authors.lastname: Poças
authors.forename: Filomena
authors.initials: F
authors.lastname: Azevedo
mesh_terms: D015932:Complement C3c / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D011928:Raynaud Disease / Q000209:etiology; D014581:Urticaria / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
chemical_list: D003181:Complement C4; D006886:Hydroxychloroquine; D015932:Complement C3c; D011241:Prednisone