title: Involvement of cathepsin D during tail regression in tadpoles of the common Indian tree frog, Polypedates maculatus (Anura: Rhacophoridae).
abstract: Cathepsin D, an aspartyl protease, plays a key role in the metabolic degradation of intracellular proteins in an acidic milieu of lysosomes. Proteolysis plays an essential role in anuran tail regression and a wide variety of thyroid hormone induced proteolytic enzymes have been reported to be involved in the regressing tail. The present study describes the trend of specific activity of cathepsin D in the tail of different developmental stages and immunohistochemical localization of cathepsin D during degradation of various tail tissues in the tadpoles of Polypedates maculatus. Cathepsin D has been found to be involved in the degradation of major tail tissues such as epidermis, muscle, spinal cord, notochord cells and blood cells in the regressing tail. Interestingly, it has also been found to be involved in the pre-regressing tail prior to visible tail regression. In addition, melanocytes have been described to be associated with degradation of different tail tissues.
authors.affiliation: Cell and Developmental Biology Laboratory, P.G. Department of Zoology, Utkal University, Orissa, India.
authors.forename: Cuckoo
authors.initials: C
authors.lastname: Mahapatra
authors.forename: Pravati Kumari
authors.initials: PK
authors.lastname: Mahapatra
mesh_terms: D000818:Animals; D001001:Anura / Q000254:growth & development* / Q000378:metabolism*; D002402:Cathepsin D / Q000032:analysis / Q000378:metabolism*; D007150:Immunohistochemistry; D007814:Larva / Q000201:enzymology / Q000254:growth & development; D013623:Tail / Q000201:enzymology* / Q000254:growth & development*
chemical_list: D002402:Cathepsin D