title: [Treatment of patients with moderate and severe nonpsychotic depressions].
abstract: Twenty-three patients with moderate and severe nonpsychotic depressions without psychotic symptoms were treated with valdoxan during 8 weeks. Valdoxan was used in the combination with antidepressants and tranquilizers in 73.9% patients, the latter drugs were withdrawn after 3-6 weeks in 65.3% of cases. The distinct positive changes in the mental state of patients were seen on CGI-I and HADM-21 scales. To the end of the study, 69.6% of patients were practically healthy according to the CGI-S scale; 17.4% had border-line psychiatric disorder without symptoms of depression; 13% had mild depressive symptoms. No significant side-effects were observed in 91.3% of patients.
authors.forename: M V
authors.initials: MV
authors.lastname: Zlokazova
mesh_terms: D000081:Acetamides / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014149:Tranquilizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives; D014149:Tranquilizing Agents; C084711:agomelatine; D009281:Naphthalenes