title: Detecting directional selection in the presence of recent admixture in African-Americans.
abstract: We investigate the performance of tests of neutrality in admixed populations using plausible demographic models for African-American history as well as resequencing data from African and African-American populations. The analysis of both simulated and human resequencing data suggests that recent admixture does not result in an excess of false-positive results for neutrality tests based on the frequency spectrum after accounting for the population growth in the parental African population. Furthermore, when simulating positive selection, Tajima's D, Fu and Li's D, and haplotype homozygosity have lower power to detect population-specific selection using individuals sampled from the admixed population than from the nonadmixed population. Fay and Wu's H test, however, has more power to detect selection using individuals from the admixed population than from the nonadmixed population, especially when the selective sweep ended long ago. Our results have implications for interpreting recent genome-wide scans for positive selection in human populations.
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. k.lohmueller@berkeley.edu
authors.forename: Kirk E
authors.initials: KE
authors.lastname: Lohmueller
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Bustamante
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Clark
mesh_terms: D001741:Black or African American / Q000235:genetics*; D044383:Black People / Q000235:genetics; D003198:Computer Simulation; D003710:Demography; D040961:Genetic Drift; D006239:Haplotypes; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D012641:Selection, Genetic