title: What is new with Nods?
abstract: Over the last few years, much research has focused on determining the function of members of the cytosolic Nod-like receptor (NLR) family in terms of their triggers and the signaling pathways that they control. Members of this family include the NLRP proteins, which play a role in sensing both microbial and danger signals and triggering the caspase-1 dependent inflammasome, and the Nod subfamily characterized by proteins with a caspase-activating and recruitment domain (CARD) or a so-called 'X' domain. Nod1, Nod2, NLRX1 and NLRC5 are all members of this subfamily and in this review, we will focus on recent work that has shown the importance of these molecules in both pathogen sensing and regulation of innate and adaptive immunity.
authors.affiliation: Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.
authors.forename: Joao G
authors.initials: JG
authors.lastname: Magalhaes
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Sorbara
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Girardin
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Philpott
mesh_terms: D000818:Animals; D001343:Autophagy; D053468:CARD Signaling Adaptor Proteins / Q000276:immunology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology; D024101:Mitochondrial Proteins / Q000276:immunology
chemical_list: D053468:CARD Signaling Adaptor Proteins; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins