title: [Influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal ischemia - reperfusion(I/R) injury].
abstract: OBJECTIVE
  To study the influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal I/R and their mechanism of action.
  
  
  METHODS
  Models of rabbits intestinal I/R injury were made. The effect of astragalus and zinc sulfate on the viscosity and malondialdehyde (MDA) in erythrocyte membrane, superoxide dismutase (SOD) in erythrocyte, oxidase (XO) in plasma and MDA tissues homogenate were observed.
  
  
  RESULTS
  The administration of astragalus and zinc sulfate decreased viscosity and MDA and XO, prevented the reduction of SOD, and alleviated I/R injury.
  
  
  CONCLUSIONS
  Lipid peroxidation injury of the erythrocyte membrane was one of the pathogenesis of I/R injury, and astragalus and the zinc sulfate possessed effects of anti-lipid peroxide, stabilized erythrocyte membrane, increased red blood cell deform ability and raised microcircular perfusion.
authors.affiliation: Department of Physiology of North China Coal Medical College, Tangshan 063000, China.
authors.forename: Chun-Xiu
authors.initials: CX
authors.lastname: Zhao
authors.forename: You-Ling
authors.initials: YL
authors.lastname: Jing
authors.forename: Lian-Fei
authors.initials: LF
authors.lastname: Chai
authors.forename: Guo-Xian
authors.initials: GX
authors.lastname: Duan
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Li
authors.forename: Shuo-Sen
authors.initials: SS
authors.lastname: Zhang
authors.forename: He-Qin
authors.initials: HQ
authors.lastname: Cui
mesh_terms: D000818:Animals; D027883:Astragalus Plant; D001809:Blood Viscosity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D007422:Intestines / Q000098:blood supply / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010088:Oxidoreductases / Q000032:analysis; D011817:Rabbits; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology*; D013482:Superoxide Dismutase / Q000032:analysis; D019287:Zinc Sulfate / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D019287:Zinc Sulfate; D010088:Oxidoreductases; D013482:Superoxide Dismutase