title: Chest tcpO2 changes during constant-load treadmill walking tests in patients with claudication.
abstract: Changes in chest transcutaneous-pO(2) at rest (ΔtcpO(2)) mimic absolute changes in arterial-pO(2) during moderate exercise, although the absolute starting values may dramatically differ. We retrospectively studied 485 patients (group 1), prospectively studied 292 new patients (group 2) and estimated the intra-test and the test-retest reproducibility of ΔtcpO(2) during constant-load treadmill tests: 3.2 km h(-1), 10% grade, using the cross correlation technique. Patients were classified into groups according to their best fit to nine pre-defined mathematic models. Respectively, 71% and 76% of patients of groups 1 and 2 fitted with a model showing a ΔtcpO(2) increase during and a decrease following exercise. Another 18% and 12% of the patients of groups 1 and 2 respectively fitted with a model that showed an abrupt decrease at exercise onset, a slow increase during walking and an overshoot in the recovery period, referred here as a walking-induced transcutaneous hack (WITH) profile. The mean r(max) value for the cross-correlation analysis was 0.919 ± 0.091 and 0.800 ± 0.129 for intra-test and test-retest reproducibility. Most profiles show the expected ΔtcpO(2) exercise-induced increase. Future studies are needed to confirm and explain the WITH profiles that we found, and screen for potential-associated diseases.
authors.affiliation: Laboratory of Physiology, CNRS, UMR6214, Angers, F-49045 France, Inserm, U771, Angers, F-49045 France.
authors.forename: N
authors.initials: N
authors.lastname: Ouedraogo
authors.forename: M
authors.initials: M
authors.lastname: Feuilloy
authors.forename: G
authors.initials: G
authors.lastname: Mahe
authors.forename: G
authors.initials: G
authors.lastname: Leftheriotis
authors.forename: J-L
authors.initials: JL
authors.lastname: Saumet
authors.forename: P
authors.initials: P
authors.lastname: Abraham
mesh_terms: D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D012867:Skin / Q000378:metabolism*; D013909:Thorax / Q000378:metabolism*; D016138:Walking
chemical_list: D010100:Oxygen