title: [Significance of the secreted frizzled-related protein 2 expression in earlobe keloid].
abstract: OBJECTIVE
  To investigate the expression and the role of secreted frizzled-related protein 2 (SFRP2) in the earlobe keloid and find a valid way to treat the keloid with gene therapy.
  
  
  METHODS
  The expression of SFRP2 mRNA and protein was tested with in situ hybridization and Western Blot Analysis method in the different period of earlobe keloid.
  
  
  RESULTS
  The SFRP2 mRNA and protein expression at the keloid edge was significantly high in 12 month group than in 3 or 6 month groups (P < 0.01), but not than in 24 month group. The SFRP2 expression started to decrease in the keloid center 12 month later (P < 0.01). The SFRP2 expression was always higher in edge than in center during all the period (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  The results suggest that SFRP2 may play an important role in the development of keloid, especially at the keloid edge. The high SFRP2 expression in endothelial cells and surrounding tissue is also important. It may be a new way for gene therapy of keloid by decreasing the SFRP2 expression.
authors.affiliation: Department of Plastic Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
authors.forename: Zhi-Cheng
authors.initials: ZC
authors.lastname: Sun
authors.forename: Chuan
authors.initials: C
authors.lastname: Cao
authors.forename: Zhen-Xiang
authors.initials: ZX
authors.lastname: Wang
authors.forename: Ju-Long
authors.initials: JL
authors.lastname: Wu
authors.forename: Bing
authors.initials: B
authors.lastname: Ma
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D004423:Ear; D005260:Female; D006801:Humans; D007627:Keloid / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D055815:Young Adult; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D008565:Membrane Proteins; C109618:SFRP2 protein, human; D000094742:Secreted Frizzled-Related Proteins