title: Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.
abstract: BACKGROUND
  The NADH-ubiquinone oxidoreductase flavoprotein gene (NDUFV2), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.
  
  
  METHODS
  We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese.
  
  
  RESULTS
  Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the NDUFV2 gene promoter variants and schizophrenia in Han Chinese.
  
  
  CONCLUSIONS
  The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.forename: Jinsong
authors.initials: J
authors.lastname: Tang
authors.forename: Liwen
authors.initials: L
authors.lastname: Tan
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Yao
mesh_terms: D044466:Asian People / Q000235:genetics* / Q000523:psychology; D002681:China / Q000453:epidemiology / Q000208:ethnology; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D009245:NADH Dehydrogenase / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*
chemical_list: D009245:NADH Dehydrogenase; C492562:NDUFV2 protein, human