title: [Effects of shenmai injection on lipid peroxidation in the lung following with ischemia/ reperfusion (I/R) injury of limb].
abstract: OBJECTIVE
  To explore the effects of shenmai (Chinese transitional medicine) injection on lipid peroxidation in the lung following with ischemia/reperfusion (I/R) injury of limb.
  
  
  METHODS
  The models of I/R injury of limb were constructed in rabbits. Superoxide dismutase (SOD) and malondialdehyde (MDA) in into and out-flowing pulmonary blood (IPB, OPB) and lung tissue were measured, as well as the effects of shenmai injection were observed.
  
  
  RESULTS
  Compared with sham group, the activity of SOD in IPB, OPB and lung tissue were decreased, and the content of MDA was increased after 4 h ischemia followed by 4 h reperfusion. SOD increased and MDA decreased significantly by icy shenmai injection 30 min before reperfusion. The correlation analysis indicated that MDA was negatively correlated with SOD .
  
  
  CONCLUSIONS
  Oxygen free radicals metabolic confusion of lung occurred in the course of I/R, shenmai injection can alleviate lipid peroxidation, get rid of free radicals and inhibit the damage of lung.
authors.affiliation: Department of Physiology of North China Coal Medical College, Tangshan 063000, China.
authors.forename: Yang-Lei
authors.initials: YL
authors.lastname: Wang
authors.forename: You-Ling
authors.initials: YL
authors.lastname: Jing
authors.forename: Jing-Xia
authors.initials: JX
authors.lastname: Zhao
authors.forename: Guo-Xian
authors.initials: GX
authors.lastname: Duan
authors.forename: Xiu-Hong
authors.initials: XH
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005121:Extremities / Q000098:blood supply; D007511:Ischemia / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D011817:Rabbits; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination; D008315:Malondialdehyde; D013482:Superoxide Dismutase