title: Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21.
abstract: In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P = 1.00 × 10⁻⁷) and the implicated 6p-risk region spans around 10 Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits.
authors.affiliation: Institute of Medical Biometry and Statistics, University at Lübeck, Germany.
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Johannes
authors.initials: J
authors.lastname: Schumacher
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: André
authors.initials: A
authors.lastname: Kleensang
authors.forename: Kerstin U
authors.initials: KU
authors.lastname: Ludwig
authors.forename: Tiemo
authors.initials: T
authors.lastname: Grimm
authors.forename: Nina
authors.initials: N
authors.lastname: Neuhoff
authors.forename: Maike
authors.initials: M
authors.lastname: Preis
authors.forename: Darina
authors.initials: D
authors.lastname: Roeske
authors.forename: Andreas
authors.initials: A
authors.lastname: Warnke
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: Helmut
authors.initials: H
authors.lastname: Remschmidt
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: Gerd
authors.initials: G
authors.lastname: Schulte-Körne
mesh_terms: D002648:Child; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D003071:Cognition; D004410:Dyslexia / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D040641:Quantitative Trait Loci / Q000235:genetics*
chemical_list: D005819:Genetic Markers