title: Platelet-derived microparticles - an updated perspective.
abstract: Platelet-derived microparticles (PMP) are a heterogeneous population of vesicles (< 1 mm) generated from the plasma membrane upon platelet activation by various stimuli. They are a discrete population differing from the exosomes which originate from the intracellular multivesicular bodies. PMP also differ from the microparticles derived from megakaryocytes despite the presence of several identical surface markers on the latter. The molecular properties and the functional roles of the PMP are beginning to be elucidated by the rapidly evolving research interest, but novel questions are simultaneously raised. This updated perspective discusses the most recent highlights in the PMP research in context with the methodological problems and the paradoxical role of the PMP in health and disease.
authors.affiliation: Department of Biosciences, Division of Biochemistry, University of Helsinki, Finland. Pia.Siljander@helsinki.fi
authors.forename: Pia R M
authors.initials: PR
authors.lastname: Siljander
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure*; D002458:Cell Fractionation; D055252:Cell-Derived Microparticles / Q000502:physiology* / Q000648:ultrastructure*; D005434:Flow Cytometry; D006801:Humans; D039661:Integrin beta3 / Q000097:blood; D051379:Mice; D010718:Phosphatidylserines; D015539:Platelet Activation / Q000502:physiology; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism; D040201:Platelet Membrane Glycoprotein IIb / Q000097:blood
chemical_list: D039661:Integrin beta3; D010718:Phosphatidylserines; D019038:Platelet Glycoprotein GPIb-IX Complex; D040201:Platelet Membrane Glycoprotein IIb