title: Synthesis and antimicrobial activity of novel 5-amino-4-cyano-1H-pyrazole and quinazolin-4(3H)-one derivatives.
abstract: New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.
authors.affiliation: Department of Chemistry, Faculty of Science, Menofeia University, Shebin-El-Koom 12345, Egypt. mtaha2000_2000@yahoo.com
authors.forename: Mohamed T
authors.initials: MT
authors.lastname: Abdel-Aal
authors.forename: Abdel-Aleem H
authors.initials: AA
authors.lastname: Abdel-Aleem
authors.forename: Laila I
authors.initials: LI
authors.lastname: Ibahim
authors.forename: Ahmed L
authors.initials: AL
authors.lastname: Zein
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C559582:5-amino-4-cyano-1H-pyrazole; D000890:Anti-Infective Agents; D006835:Hydrazones; D011720:Pyrazoles; D052999:Quinazolinones