title: Long-term outcome and impact of surgery on adults with coronary arteries originating from the opposite coronary cusp.
abstract: BACKGROUND
  An anomalous coronary artery from the opposite sinus of Valsalva may increase sudden death risk in children and young adults, and surgical intervention is often recommended. The impact of this lesion when recognized in the adult and its management are ill defined.
  
  
  RESULTS
  We reviewed 210 700 cardiac catheterizations performed over a 35-year period at a single institution and identified 301 adults with an anomalous coronary artery from the opposite sinus of Valsalva, either anomalous right coronary artery from the left cusp or anomalous left main coronary artery from the right cusp. Patients were stratified by the pathway of the anomalous artery and the chosen treatment. Among the 301 patients with anomalous coronary artery from the opposite sinus of Valsalva (0.14% of the cohort), 79% had anomalous right coronary artery from the left cusp, and 18% had an interarterial course (IAC). Patients with IAC were younger (52±13 versus 59±13 years; P=0.001) and more likely to undergo surgical intervention (52% versus 27%; P<0.001), but mortality was not increased with IAC. Among the 54 patients with IAC, 28 underwent surgical repair with no perioperative deaths. Patients evaluated since 2000 were significantly more likely to be referred for surgery (P=0.004). Surgical patients were more likely to have abnormal stress tests (90% versus 43%; P=0.01) and had more extensive atherosclerosis but less diabetes mellitus (0% versus 23%; P=0.01). Long-term survival at 10 years appeared similar in both groups.
  
  
  CONCLUSIONS
  In this single-center cohort study of patients with an anomalous coronary artery from the opposite sinus of Valsalva, surgical management appears to have been favored recently. Despite no perioperative mortality, a positive impact on long-term survival was not observed. The impact of surgery in older adults with anomalous coronary arteries arising from the opposite coronary sinus with IAC deserves further study.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA. krasusr@ccf.org
authors.forename: Richard A
authors.initials: RA
authors.lastname: Krasuski
authors.forename: Dari
authors.initials: D
authors.lastname: Magyar
authors.forename: Stephen
authors.initials: S
authors.lastname: Hart
authors.forename: Vidyasagar
authors.initials: V
authors.lastname: Kalahasti
authors.forename: Richard
authors.initials: R
authors.lastname: Lorber
authors.forename: Robert
authors.initials: R
authors.lastname: Hobbs
authors.forename: Gosta
authors.initials: G
authors.lastname: Pettersson
authors.forename: Eugene
authors.initials: E
authors.lastname: Blackstone
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D015331:Cohort Studies; D003330:Coronary Vessel Anomalies / Q000175:diagnosis / Q000601:surgery*; D003331:Coronary Vessels / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods* / Q000401:mortality; D012189:Retrospective Studies; D012850:Sinus of Valsalva / Q000002:abnormalities* / Q000601:surgery*; D015996:Survival Rate; D013895:Thoracic Arteries / Q000601:surgery; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000379:methods / Q000401:mortality