title: [Glucocorticoid treatment for cochlear ischemic and acoustic injuries].
abstract: The effect of glucocorticoids on sensorineural hearing loss of sudden onset remains to be controversial although glucocorticoids have been used for treatment of sudden sensorineural hearing loss. We review recent findings about the effect of glucocorticoids on cochlear ischemic and acoustic injuries obtained from animal experiments. Systemically administered glucocorticoids penetrate the blood-cochlear barrier well. Glucocorticoids ameliorated the cochlear ischemic and acoustic injuries at a relatively wide range of doses, and they protect cochlear hair cells in these types of injury. The therapeutic actions of glucocorticoids in cochlear injuries were considered to be mediated via both genomic and non-genomic pathways. Based on the results obtained in acoustic injury, therapeutic time window of glucocorticoids is considered to be short after the onset of injury. These findings obtained from animal experiments are important in considering clinical usage of glucocorticoids for the treatment of sensorineural hearing loss.
authors.affiliation: Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba.
authors.forename: Keiji
authors.initials: K
authors.lastname: Tabuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Hara
mesh_terms: D000818:Animals; D003051:Cochlea / Q000098:blood supply* / Q000293:injuries*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D051379:Mice
chemical_list: D005938:Glucocorticoids