title: QuEChERS multiresidue method validation and mass spectrometric assessment for the novel anthranilic diamide insecticides chlorantraniliprole and cyantraniliprole.
abstract: The gas-phase dissociation reactions of chlorantraniliprole (Rynaxypyr) and cyantraniliprole (Cyazypyr) have been studied in triple-quadrupole, ion trap, and orbitrap mass spectrometers equipped with electrospray and desorption electrospray ion sources, revealing the formation of odd-electron fragment ions, the structures of which were elucidated. The odd-electron fragments were unusually abundant, and their formation is proposed to occur via a tricyclic intermediate. The applicability of the QuEChERS multiresidue method for the quantitation of chlorantraniliprole and cyantraniliprole was also assessed in this study. Four matrices representative of oily, watery, acidic, and dry crop groups were tested, with a targeted limit of quantitation (LOQ) of 0.01 mg/kg. Average recoveries ranged between 87 and 107%, with relative standard deviations (RSD) of ≤ 8%. Linear calibration functions with correlation coefficients r > 0.99 were obtained. The study provides an expansion of the QuEChERS method to include anthranilic diamides and a mass spectrometric assessment for these two novel agrochemical active ingredients.
authors.affiliation: PTRL Europe GmbH, Science Park I, D-89081 Ulm, Germany. sergio.c.nanita@usa.dupont.com
authors.forename: Timo
authors.initials: T
authors.lastname: Schwarz
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Snow
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Santee
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Mulligan
authors.forename: Thomas
authors.initials: T
authors.lastname: Class
authors.forename: Michael P
authors.initials: MP
authors.lastname: Wadsley
authors.forename: Sergio C
authors.initials: SC
authors.lastname: Nanita
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005504:Food Analysis / Q000379:methods*; D013058:Mass Spectrometry; D010573:Pesticide Residues / Q000032:analysis*; D011720:Pyrazoles / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D062367:ortho-Aminobenzoates / Q000032:analysis*
chemical_list: D010573:Pesticide Residues; D011720:Pyrazoles; D062367:ortho-Aminobenzoates; C517733:chlorantranilipole; C558219:cyantraniliprole