title: Dietary restriction prevents diabetogenic effect of streptozotocin in mice.
abstract: The beneficial role of dietary restriction (DR) was studied in streptozotocin (STZ)-induced diabetes in mice. The DR mice exhibited the lower blood glucose (mg/dl) level as compared to ad libitum (AL) fed ones. After 3 months' DR, STZ treatment to both AL and DR mice showed significant (p < 0.001) elevation of the blood glucose level in AL-fed mice, while a lower level of glucose was maintained in DR-fed mice. The ability of maintaining a low blood glucose level in STZ-treated DR mice indicated that STZ might have been ineffective from its action on beta cells of pancreas by long-term DR. Thus, these findings suggested that DR may be an important tool for preventing the diabetic conditions. However, further studies are required to know the mechanism(s) of DR protection against diabetogenic action of STZ in experimental animals.
authors.affiliation: Defence Institute of Bio-Energy Research, Molecular Biology & Genetic Engineering Division, DRDO, P.O. Arjunpur (Haldwani) 263 139, Nainital (Uttarakhand), India.
authors.forename: D
authors.initials: D
authors.lastname: Goyary
authors.forename: R
authors.initials: R
authors.lastname: Sharma
mesh_terms: D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000517:prevention & control*; D004032:Diet; D004195:Disease Models, Animal; D005947:Glucose / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000166:cytology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010179:Pancreas / Q000378:metabolism; D013311:Streptozocin / Q000009:adverse effects* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D013311:Streptozocin; D005947:Glucose