title: An enantioselective synthesis of (+)-polyoxamic acid via phase-transfer catalytic conjugate addition and asymmetric dihydroxylation.
abstract: A new enantioselective synthetic method of (+)-polyoxamic acid is reported. (+)-Polyoxamic acid could be obtained in 7 steps with 46% overall yield from diphenylmethyl-glycineimine tert-butyl ester via an enantioselective phase-transfer conjugate addition (99% yield, 96% ee) and an asymmetric dihydroxylation (98% yield, 94% de) as the key reactions.
authors.affiliation: Marine Natural Products Chemistry Laboratory, Korea Ocean Research and Development Institute, Ansan 426-744, Korea.
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Yohan
authors.initials: Y
authors.lastname: Park
authors.forename: Mi-hyun
authors.initials: MH
authors.lastname: Kim
authors.forename: Sang-sup
authors.initials: SS
authors.lastname: Jew
authors.forename: Hyeung-geun
authors.initials: HG
authors.lastname: Park
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006900:Hydroxylation; D015394:Molecular Structure; D013237:Stereoisomerism; D013400:Sugar Acids / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D013400:Sugar Acids; C529752:polyoxamic acid