title: [Long term outcome in children of mothers with gestational diabetes].
abstract: OBJECTIVE
  To appreciate, in epidemiological studies, the impact of fetal exposure to gestational diabetes on the long term outcome of the offspring (type 2 diabetes, overweight and obesity, metabolic syndrome and neurological complications).
  
  
  METHODS
  A systematic search was conducted in Medline between January 1990 and April 2010. Prospective studies (follow-up of the offspring born of mothers with gestational diabetes) and retrospective studies (questionnaire about the parents'history of diabetes in diabetic patients) were searched and analysed.
  
  
  RESULTS
  The fetal exposure to maternal gestational diabetes is a moderate risk factor for metabolic syndrome in the offspring. But some other perinatal risk factors of metabolic syndrome carry a bigger influence. The influence of genetic factors and maternal overweight may not be easily distinguished from the impact of fetal exposure to gestational diabetes.
  
  
  CONCLUSIONS
  It remains uncertain if the control of maternal glycemia alone may be effective and sufficient to prevent the metabolic syndrome in the adult-aged offspring.
authors.affiliation: Inserm, UMR 5953, Recherche épidémiologique en Santé périnatale et Santé des femmes et des enfants, Hôpital Cochin, 1 boulevard Jeanne d'Arc, 75014 Paris, France. antoine.burguet@chu-dijon.fr
authors.forename: A
authors.initials: A
authors.lastname: Burguet
mesh_terms: D000328:Adult; D002648:Child; D016241:Child of Impaired Parents; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D016640:Diabetes, Gestational; D005260:Female; D006801:Humans; D008659:Metabolic Diseases / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology; D011247:Pregnancy; D012307:Risk Factors; D013997:Time Factors