title: Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease.
abstract: Apolipoprotein C-I (apoC-I) is a 6.6kDa serum protein associated with high density lipoproteins (HDL) and triglyceride-rich lipoproteins. In this study, apoC-I was examined in high density lipoprotein subfractions from individuals with and without coronary artery disease (CAD). New isoforms of apoC-I, were detected in the cohort of individuals with CAD using mass spectrometry while the expected apoC-I isoforms were absent. In addition, the apoC-I mass spectra for the CAD cohort had satellite peaks indicative of the involvement of oxidative processes. Further analysis of the mass spectra of the CAD and non-CAD cohorts suggest that the origin of these new isoforms may be due to genetic mutations that could compromise the function of apoC-I.
authors.affiliation: Laboratory for Cardiovascular Chemistry, Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
authors.forename: D'Vesharronne
authors.initials: D
authors.lastname: Moore
authors.forename: Catherine
authors.initials: C
authors.lastname: McNeal
authors.forename: Ronald
authors.initials: R
authors.lastname: Macfarlane
mesh_terms: D053302:Apolipoprotein C-I / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D020033:Protein Isoforms / Q000097:blood / Q000235:genetics / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D053302:Apolipoprotein C-I; D020033:Protein Isoforms