title: [Alkaloids from Senecio scandens].
abstract: OBJECTIVE
  To investigate the alkaloids from Senecio scandens.
  
  
  METHODS
  Compounds were isolated with silica gel and Sephadex LH-20 column chromatography and their structures were determined by spectral analysis and chemical evidence. The hepatic cytotoxicity of isolated compounds was tested by MTT method in vitro.
  
  
  RESULTS
  Six alkaloids were obtained and identified as adonifoline (1), 7-angeloylturneforcidine (2), hordenine (3), 1, 3, 6, 6-tetramethyl-5, 6, 7, 8-tetrahydro-isoquinolin-8-one (4), 4-(pyrrolidin-2-one) -phenyl acetic acid (5), (4-pyrrolidinophenyl) acetic acid (6).
  
  
  CONCLUSIONS
  Compound 6 is a new natural product, compounds 3, 4 were obtained from the genus Senecio for the first time, compounds 2, 5 were obtained from this plant for the first time. Compound 1 showed significant growth inhibitory effect against hepatocyte at 100 micromol x L(-1).
authors.affiliation: Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
authors.forename: Daopeng
authors.initials: D
authors.lastname: Tan
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Lili
authors.initials: L
authors.lastname: Ji
authors.forename: Guixin
authors.initials: G
authors.lastname: Chou
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Wang
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003911:Dextrans / Q000737:chemistry; D022781:Hepatocytes; D007783:Lactones / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D011763:Pyrrolizidine Alkaloids / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D012674:Senecio / Q000737:chemistry*; D058428:Silica Gel; D014439:Tyramine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D003911:Dextrans; D007783:Lactones; D011763:Pyrrolizidine Alkaloids; C546218:adonifoline; D058428:Silica Gel; C025614:sephadex; C007964:hordenine; D019342:Acetic Acid; D014439:Tyramine