title: 6-Benzylamino 4-oxo-1,4-dihydro-1,8-naphthyridines and 4-oxo-1,4-dihydroquinolines as HIV integrase inhibitors.
abstract: SAR studies on the quinolone carboxylic acid class of HIV-1 integrase inhibitors focused on improving the metabolic stability and led to the discovery of 27 and 38.
authors.affiliation: Department of Discovery Chemistry, Ardea Biosciences, Inc., 4939 Directors Place, San Diego, CA 92121, USA.
authors.forename: Johnny Y
authors.initials: JY
authors.lastname: Nagasawa
authors.forename: Jenny
authors.initials: J
authors.lastname: Song
authors.forename: Huanming
authors.initials: H
authors.lastname: Chen
authors.forename: Hong-Woo
authors.initials: HW
authors.lastname: Kim
authors.forename: Julie
authors.initials: J
authors.lastname: Blazel
authors.forename: Samedy
authors.initials: S
authors.lastname: Ouk
authors.forename: Bettina
authors.initials: B
authors.lastname: Groschel
authors.forename: Virginia
authors.initials: V
authors.lastname: Borges
authors.forename: Voon
authors.initials: V
authors.lastname: Ong
authors.forename: Li-Tain
authors.initials: LT
authors.lastname: Yeh
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Girardet
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Vernier
authors.forename: Anneke K
authors.initials: AK
authors.lastname: Raney
authors.forename: Anthony B
authors.initials: AB
authors.lastname: Pinkerton
mesh_terms: D000818:Animals; D004285:Dogs; D015658:HIV Infections / Q000188:drug therapy; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology*; D015497:HIV-1 / Q000201:enzymology*; D000882:Haplorhini; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism*; D009287:Naphthyridines / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C544515:1,4-dihydroquinoline; D019428:HIV Integrase Inhibitors; D009287:Naphthyridines; D011804:Quinolines