title: Targeted temperature management in critical care: a report and recommendations from five professional societies.
abstract: OBJECTIVE
  Representatives of five international critical care societies convened topic specialists and a nonexpert jury to review, assess, and report on studies of targeted temperature management and to provide clinical recommendations.
  
  
  METHODS
  Questions were allocated to experts who reviewed their areas, made formal presentations, and responded to questions. Jurors also performed independent searches. Sources used for consensus derived exclusively from peer-reviewed reports of human and animal studies.
  
  
  METHODS
  Question-specific studies were selected from literature searches; jurors independently determined the relevance of each study included in the synthesis.
  
  
  CONCLUSIONS
  1) The jury opines that the term "targeted temperature management" replace "therapeutic hypothermia." 2) The jury opines that descriptors (e.g., "mild") be replaced with explicit targeted temperature management profiles. 3) The jury opines that each report of a targeted temperature management trial enumerate the physiologic effects anticipated by the investigators and actually observed and/or measured in subjects in each arm of the trial as a strategy for increasing knowledge of the dose/duration/response characteristics of temperature management. This enumeration should be kept separate from the body of the report, be organized by body systems, and be made without assertions about the impact of any specific effect on the clinical outcome. 4) The jury STRONGLY RECOMMENDS targeted temperature management to a target of 32°C-34°C as the preferred treatment (vs. unstructured temperature management) of out-of-hospital adult cardiac arrest victims with a first registered electrocardiography rhythm of ventricular fibrillation or pulseless ventricular tachycardia and still unconscious after restoration of spontaneous circulation (strong recommendation, moderate quality of evidence). 5) The jury WEAKLY RECOMMENDS the use of targeted temperature management to 33°C-35.5°C (vs. less structured management) in the treatment of term newborns who sustained asphyxia and exhibit acidosis and/or encephalopathy (weak recommendation, moderate quality of evidence).
authors.affiliation: University of Chicago, Chicago, IL, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Nunnally
authors.forename: Roman
authors.initials: R
authors.lastname: Jaeschke
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: Bellingan
authors.forename: Jacques
authors.initials: J
authors.lastname: Lacroix
authors.forename: Bruno
authors.initials: B
authors.lastname: Mourvillier
authors.forename: Gloria M
authors.initials: GM
authors.lastname: Rodriguez-Vega
authors.forename: Sten
authors.initials: S
authors.lastname: Rubertsson
authors.forename: Theodoros
authors.initials: T
authors.lastname: Vassilakopoulos
authors.forename: Craig
authors.initials: C
authors.lastname: Weinert
authors.forename: Sergio
authors.initials: S
authors.lastname: Zanotti-Cavazzoni
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Buchman
mesh_terms: D000328:Adult; D000368:Aged; D001831:Body Temperature / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D003422:Critical Care / Q000592:standards; D016638:Critical Illness / Q000401:mortality* / Q000628:therapy; D005260:Female; D006323:Heart Arrest / Q000517:prevention & control; D006801:Humans; D007036:Hypothermia, Induced / Q000592:standards; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012955:Societies, Medical / Q000592:standards; D016019:Survival Analysis; D013696:Temperature; D014481:United States