title: Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice.
abstract: We examined juvenile social recognition and discrimination in mice with early post-natal onset, transgenic CRF over-expression (CRF-OE) and in their wild-type littermates (WT). CRF-OE mice showed enhanced social investigation during the first encounter, normal short-term and facilitated long-term social recognition memory, compared to WT. These results suggest that chronically elevated brain CRF tone may contribute in better remembering ethologically relevant and emotionally salient stimuli, such as social interaction.
authors.affiliation: Department of Pharmacology, University of Cambridge, Cambridge, UK.
authors.forename: Maki
authors.initials: M
authors.lastname: Kasahara
authors.forename: Lucianne
authors.initials: L
authors.lastname: Groenink
authors.forename: Martien J H
authors.initials: MJ
authors.lastname: Kas
authors.forename: Elisabeth Y
authors.initials: EY
authors.lastname: Bijlsma
authors.forename: Berend
authors.initials: B
authors.lastname: Olivier
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Sarnyai
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D021641:Recognition, Psychology / Q000502:physiology*; D012919:Social Behavior
chemical_list: D003346:Corticotropin-Releasing Hormone