title: Available fluoride in toothpastes used by Brazilian children.
abstract: Toothpastes should have a minimum concentration of 1000 ppm of fluoride (F) to control caries and also the active F agent must be chemically free (soluble) in the formulation. Thus, the aim of this study was to evaluate the concentration of soluble F in dentifrices used by 206 Brazilian children. The concentrations of total fluoride (TF), total soluble fluoride (TSF) and fluoride ion were determined. From these analyses, the concentrations of F as sodium monofluorophosphate (MFP) and % of insoluble F were calculated. F was analyzed with an ion specific electrode in duplicates. The majority of dentifrices used (96%) contained F and in 84% of them, TF concentration was according to that declared by the manufacturers. In the F-toothpastes, 78% showed TSF concentration ≥ 1000 ppm, varying from 422.3 to 1432.3 ppm F (mean ± SD of 1017.6 ± 239.4). These findings suggest that most dentifrices used by Brazilian children present available fluoride concentration for caries control.
authors.affiliation: Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil. jcury@fop.unicamp.br
authors.forename: Jaime Aparecido
authors.initials: JA
authors.lastname: Cury
authors.forename: Maria José Lages de
authors.initials: MJ
authors.lastname: Oliveira
authors.forename: Carolina Castro
authors.initials: CC
authors.lastname: Martins
authors.forename: Livia Maria Andaló
authors.initials: LM
authors.lastname: Tenuta
authors.forename: Saul Martins
authors.initials: SM
authors.lastname: Paiva
mesh_terms: D001682:Biological Availability; D001938:Brazil; D002327:Cariostatic Agents / Q000032:analysis* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D002675:Child, Preschool; D005459:Fluorides / Q000032:analysis* / Q000493:pharmacokinetics; D006801:Humans; D007223:Infant; D017736:Ion-Selective Electrodes; D010710:Phosphates / Q000032:analysis; D012969:Sodium Fluoride / Q000032:analysis; D012995:Solubility; D014100:Toothpastes / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D002327:Cariostatic Agents; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides