title: 2, 4-dinitrophenol poisoning caused by non-oral exposure.
abstract: 2, 4-Dinitrophenol (2, 4-DNP) is widely used in industry, but recently, poisoning through consumption for weight control has been frequently reported. We report the cases of two patients whose deaths were attributed to occupational and non-oral exposure of 2, 4-DNP. They were all poisoned through skin absorption and respiratory tract inhalation; common features were excessive sweating, hyperthermia, tachycardia, clouded consciousness and asystole. Because of the lack of specific early symptoms, effective antidotes and the means of washing the contamination from the skin, their arrival in hospital was delayed and the supportive therapy was ineffectual. Cardiac arrest occurred quickly and unexpected after admission.
authors.affiliation: Department of Emergency, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.lastname: Jiang Jiukun
authors.lastname: Yuan Zhihua
authors.lastname: Huang Weidong
authors.lastname: Wang Jiezan
mesh_terms: D019297:2,4-Dinitrophenol / Q000008:administration & dosage / Q000506:poisoning*; D000328:Adult; D004333:Drug Administration Routes; D017809:Fatal Outcome; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011041:Poisoning / Q000209:etiology* / Q000503:physiopathology; D012869:Skin Absorption
chemical_list: D019297:2,4-Dinitrophenol