title: Cyclosporine a-nanosuspension: formulation, characterization and in vivo comparison with a marketed formulation.
abstract: Cyclosporine A-nanosuspensions were prepared using zirconium oxide beads as a milling media, Poloxamer 407 as a stabilizer and distilled water as an aqueous medium using the Pearl Milling technique. The optimized formulation was characterized in terms of particle size distribution, surface morphology, drug-surfactant interaction, drug content, saturation solubility, osmolarity, and stability. The nanoparticles consisting of Poloxamer-bound cyclosporin A with a mean diameter of 213 nm revealed a spherical shape and 5.69 fold increased saturation solubility as compared to the parent drug. The formulation was found to be iso-osmolar with blood and stable up to 3 months at 2â8ÂC. In-vivo studies were carried out in albino rats and the pharmacokinetic parameters were compared with a marketed formulation, which indicated better results of the prepared formulation than the marketed one.
authors.affiliation: Unison Pharmaceuticals, Ahmedabad, Gujarat, India. nakmahen@yahoo.com
authors.forename: Mahendra
authors.initials: M
authors.lastname: Nakarani
authors.forename: Priyal
authors.initials: P
authors.lastname: Patel
authors.forename: Jayvadan
authors.initials: J
authors.lastname: Patel
authors.forename: Pankaj
authors.initials: P
authors.lastname: Patel
authors.forename: Rayasa S R
authors.initials: RS
authors.lastname: Murthy
authors.forename: Subhash S
authors.initials: SS
authors.lastname: Vaghani