title: Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle.
abstract: Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunella vulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the ability to regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as a lung cancer chemopreventive agent.
authors.affiliation: Key Laboratory of Delivery Systems of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Jiangsu, Nanjing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Jia
authors.forename: Maomao
authors.initials: M
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001580:Benzopyrenes / Q000494:pharmacology; D002289:Carcinoma, Non-Small-Cell Lung / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018890:Chemoprevention; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D051379:Mice; D008805:Mice, Inbred A; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D031347:Prunella
chemical_list: D001580:Benzopyrenes; D010936:Plant Extracts