title: Quantification of age- and gender-related changes in diffusion tensor imaging indices in deep grey matter of the normal human brain.
abstract: This study aimed to demonstrate age-related and gender-related changes in diffusion tensor imaging (DTI) indices of deep grey matter (GM) nuclei of the normal human brain. DTI was performed on 142 subjects (age: 10-52 years). Regions of interest were placed on the caudate nucleus (CN), putamen, globus pallidus, frontal white matter (WM), occipital WM, anterior and posterior limb of internal capsule, genu of the corpus callosum and splenium in all participants. The quadratic regression model was used to describe age-related and gender-related changes in DTI indices for GM and WM. We observed increased fractional anisotropy (FA) values with age up to adulthood in GM, and a rise up to the third decade of life followed by a decrease in FA for WM. We observed higher FA values in males compared to females in CN and all WM regions. Decreased mean diffusivity with age was observed in GM and WM irrespective of gender. This normative data may be valuable in the diagnosis of neurodegenerative diseases.
authors.affiliation: Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226 014, India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Pal
authors.forename: Richa
authors.initials: R
authors.lastname: Trivedi
authors.forename: Sona
authors.initials: S
authors.lastname: Saksena
authors.forename: Abhishek
authors.initials: A
authors.lastname: Yadav
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
authors.forename: Chandra M
authors.initials: CM
authors.lastname: Pandey
authors.forename: Ram Kishore S
authors.initials: RK
authors.lastname: Rathore
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D055815:Young Adult