title: Severe raltegravir-associated rhabdomyolysis: a case report and review of the literature.
abstract: Raltegravir (RAL), an HIV integrase inhibitor, may uncommonly induce an increase of serum creatine kinase (CK) both in naïve and antiretroviral (ARV)-experienced HIV-positive patients. We report the case of severe rhabdomyolysis requiring hospitalization in an ARV-experienced HIV/hepatitis C co-infected patient treated with a RAL-containing drug regimen. Factors favouring a severe clinical occurrence of RAL-induced rhabdomyolysis from cases reported in literature are described.
authors.affiliation: Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology, University of Milan, L Sacco Hospital, Milan, Italy. francesco.croce@hotmail.it
authors.forename: F
authors.initials: F
authors.lastname: Croce
authors.forename: P
authors.initials: P
authors.lastname: Vitello
authors.forename: A
authors.initials: A
authors.lastname: Dalla Pria
authors.forename: A
authors.initials: A
authors.lastname: Riva
authors.forename: M
authors.initials: M
authors.lastname: Galli
authors.forename: S
authors.initials: S
authors.lastname: Antinori
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy; D019428:HIV Integrase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D011760:Pyrrolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D000068898:Raltegravir Potassium; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D019428:HIV Integrase Inhibitors; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase