title: Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity.
abstract: The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt. raafat_mohareb@yahoo.com
authors.forename: Rafat M
authors.initials: RM
authors.lastname: Mohareb
authors.forename: Daisy H
authors.initials: DH
authors.lastname: Fleita
authors.forename: Ola K
authors.initials: OK
authors.lastname: Sakka
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001386:Azides / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006835:Hydrazones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001386:Azides; D003374:Coumarins; D006835:Hydrazones; D011725:Pyridines; D013844:Thiazoles; D013876:Thiophenes; C030123:coumarin; C023666:pyridine