title: Darunavir, ritonavir, and etravirine pharmacokinetics in the cervicovaginal fluid and blood plasma of HIV-infected women.
abstract: We report darunavir, ritonavir, and etravirine pharmacokinetics in cervicovaginal fluid and blood plasma for women from the Gender, Race and Clinical Experience (GRACE) study. Eight women received darunavir-ritonavir (600/100 mg) twice daily (b.i.d.); two also received etravirine (200 mg) b.i.d. Week 4 paired blood plasma and cervicovaginal fluid samples were collected over 12 h. Darunavir and etravirine cervicovaginal fluid exposures were higher than blood plasma exposures; ritonavir cervicovaginal fluid exposure was lower than blood plasma exposure. The high exposures of darunavir and etravirine in cervicovaginal fluid warrant further evaluation of these drugs for use in HIV-1 prevention.
authors.affiliation: University of North Carolina at Chapel Hill, AIDS Clinical Trials Unit, 130 Mason Farm Rd., CB 7215, Chapel Hill, NC 27599-7215, USA. Kristine_patterson@med.unc.edu
authors.forename: Kristine
authors.initials: K
authors.lastname: Patterson
authors.forename: Steven
authors.initials: S
authors.lastname: Jennings
authors.forename: Ron
authors.initials: R
authors.lastname: Falcon
authors.forename: Joseph
authors.initials: J
authors.lastname: Mrus
authors.forename: Angela
authors.initials: A
authors.lastname: Kashuba
mesh_terms: D000328:Adult; D000069454:Darunavir; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009570:Nitriles; D011724:Pyridazines / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D011743:Pyrimidines; D019438:Ritonavir / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D013449:Sulfonamides / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics
chemical_list: D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D013449:Sulfonamides; C451734:etravirine; D019438:Ritonavir; D000069454:Darunavir