title: [Value of serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and LOX-1 mRNA in peripheral mononuclear cells in early diagnosis of acute coronary syndrome].
abstract: OBJECTIVE
  To assess the value of serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) levels and LOX-1 mRNA expression in peripheral blood mononuclear cells in early diagnosis of acute coronary syndrome (ACS).
  
  
  METHODS
  Enzyme-linked immunosorbent assay was used to detect the levels of plasma ox-LDL and LOX-1 in 95 patients with ACS, 60 with stable angina pectoris (SAP) and 40 normal control subjects. The expression of LOX-1 mRNA in peripheral blood mononuclear cells was detected by RT-PCR in the 3 groups.
  
  
  RESULTS
  The levels of ox-LDL, LOX-1 and LOX-1 mRNA in the peripheral blood mononuclear cells were significantly higher in ACS patients than in SAP patients and normal control subjects (P<0.05). In ACS group, the level of plasma ox-LDL was significantly correlated to serum LOX-1 and LOX-1 mRNA expression in peripheral mononuclear cells.
  
  
  CONCLUSIONS
  The level of plasma soluble LOX-1 and LOX-1 mRNA in peripheral mononuclear cells are significantly increased in ACS, and when combined, they provide a useful means for detecting ACS in the prophase.
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China. 13606818486@139.com
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Zhu
authors.forename: Ming-juan
authors.initials: MJ
authors.lastname: Shi
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D000368:Aged; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D051127:Scavenger Receptors, Class E / Q000097:blood*
chemical_list: C495137:OLR1 protein, human; D012333:RNA, Messenger; D051127:Scavenger Receptors, Class E