title: [The research on monoamine neurotransmitters changes in plasma and cerebrospinal fluid in patients with persistent vegetative state].
abstract: OBJECTIVE
  To study the relationships between the pathogenesis of persistent vegetative state (PVS) and the levels of monoamine neurotransmitters in plasmas and cerebrospinal fluids (CSFs) in patients with PVS.
  
  
  METHODS
  The high-pressure liquid chromatography (HPLC) was used to detect.
  
  
  RESULTS
  It was found that the level of dopamine (1.95 +/- 0.99) was significantly increased in plasma compared with the control (1.16 +/- 0.47) (P < 0.05), but the levels of 5-HT, TYR, TRP, GABA of plasma were insignificantly changed. In cerebrospinal fluid, the level of DA was insignificantly changed, and the level of 5-HT (0.49 +/- 0.32) was significantly decreased compared with the control (1.02 +/- 0.35) (P < 0.05), but the levels of TYR (1.36 +/- 0.11), TRP (0.63 +/- 0.40), GABA (1.15 +/- 0.61) were significantly increased respectively compared with the controls (0.40 +/- 0.24; 0.29 +/- 0.22; 0.37 +/- 0.45) (P < 0.05; P < 0.05; P < 0.01). The levels of GABA and DA in plasma were significant correlated (P < 0.05), and GABA and DA in CSF were also significant correlated (P < 0.01).
  
  
  CONCLUSIONS
  The results of this study suggested that PVS is related to the decrease of 5-HT in CSF and the increase of DA in plasma.
authors.affiliation: Department of Biochemistry, Second Military Medical University Nanjing Military Medical College, Nanjing 210099, China.
authors.forename: Xue-Fang
authors.initials: XF
authors.lastname: Hu
authors.forename: Pei-Dong
authors.initials: PD
authors.lastname: Wang
authors.forename: De-Gon
authors.initials: DG
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D015306:Biogenic Monoamines / Q000097:blood* / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018458:Persistent Vegetative State / Q000097:blood* / Q000134:cerebrospinal fluid*; D055815:Young Adult
chemical_list: D015306:Biogenic Monoamines