title: [Effect of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig].
abstract: OBJECTIVE
  To observe the effects of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig.
  
  
  METHODS
  Using inside-out configuration of patch-clamp single channel recording technique.
  
  
  RESULTS
  Puerarin 20 micromol/L, 40 micromol/L, 80 microml/L could inhibit the open-close rate of K+ channel of isolated ventricular myocyte in guinea pig. At 80 micromol/L, Po was decreased from 0.867 +/- 0.13 to 0.019 +/- 0.01 (n = 5, P < 0.05).
  
  
  CONCLUSIONS
  Puerarin can inhibit K+ channel of isolated ventricular myocyte in guinea pig. It may be the mechanism of Puerarin against arrhythmias in molecular level.
authors.affiliation: Department of Physiology, Pharmacology Cheng Du University of Traditional Chinese Medicine, Chengdu 610075, China.
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Miao
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Shen
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Zeng
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000166:cytology; D007529:Isoflavones / Q000494:pharmacology*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology
chemical_list: D007529:Isoflavones; D015221:Potassium Channels; C033607:puerarin