title: Cell cyclins: triggering elements of cancer or not?
abstract: Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy.
authors.affiliation: 4th Department of Surgery, Medical School, University of Athens, Attikon General Hospital, Athens, Greece. mixalislak@gmail.com
authors.forename: Michael
authors.initials: M
authors.lastname: Stamatakos
authors.forename: Victoria
authors.initials: V
authors.lastname: Palla
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karaiskos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Xiromeritis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Alexiou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Pateras
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kontzoglou
mesh_terms: D000818:Animals; D002453:Cell Cycle; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D016213:Cyclins