title: Effects of dairy intake on hyperuricemia and gout.
abstract: Dietary modification is frequently recommended for patients with gout. Longitudinal observational studies have shown a clear inverse relationship between low-fat dairy intake and gout risk. Several checkpoints in gout pathogenesis may be targeted by dairy intake. Cross-sectional and short-term intervention studies of healthy volunteers have demonstrated that low-fat dairy intake has a moderate urate-lowering effect. In addition, certain dairy fractions, particularly glyco-macropeptide and G600 milk fat extract, have anti-inflammatory properties in experimental models of acute gout. Such anti-inflammatory properties may contribute to the reduction in gout risk through inhibition of the inflammatory response to monosodium urate crystals within the joint. Well-controlled intervention studies in patients with gout are now needed to determine the clinical relevance of these observations in order to guide dietary recommendations for this disease.
authors.affiliation: Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand. n.dalbeth@auckland.ac.nz
authors.forename: Nicola
authors.initials: N
authors.lastname: Dalbeth
authors.forename: Kate
authors.initials: K
authors.lastname: Palmano
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002364:Caseins / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D003611:Dairy Products; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D006073:Gout / Q000178:diet therapy*; D006074:Gout Suppressants / Q000008:administration & dosage*; D006801:Humans; D033461:Hyperuricemia / Q000178:diet therapy*; D010446:Peptide Fragments / Q000008:administration & dosage
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002364:Caseins; D004041:Dietary Fats; D004044:Dietary Proteins; D006074:Gout Suppressants; D010446:Peptide Fragments; C065989:caseinomacropeptide