title: Spectroscopic visualization of nanoscale deformation in bone: interaction of light with partially disordered nanostructure.
abstract: Given that bone is an intriguing nanostructured dielectric as a partially disordered complex structure, we apply an elastic light scattering-based approach to image prefailure deformation and damage of bovine cortical bone under mechanical testing. We demonstrate that our imaging method can capture nanoscale deformation in a relatively large area. The unique structure, the high anisotropic property of bone, and the system configuration further allow us to use the transfer matrix method to study possible spectroscopic manifestations of prefailure deformation. Our sensitive yet simple imaging method could potentially be used to detect nanoscale structural and mechanical alterations of hard tissue and biomaterials in a fairly large field of view.
authors.affiliation: Purdue University, Weldon School of Biomedical Engineering, West Lafayette, IN 47906, USA.
authors.forename: Zhengbin
authors.initials: Z
authors.lastname: Xu
authors.forename: Xuanhao
authors.initials: X
authors.lastname: Sun
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Song
authors.forename: Matthew
authors.initials: M
authors.lastname: Muckley
authors.forename: Ozan
authors.initials: O
authors.lastname: Akkus
authors.forename: Young L
authors.initials: YL
authors.lastname: Kim
mesh_terms: D000818:Animals; D002417:Cattle; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D005269:Femur / Q000502:physiology*; D008027:Light; D008954:Models, Biological; D049329:Nanostructures / Q000737:chemistry*; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D012542:Scattering, Radiation; D013057:Spectrum Analysis / Q000379:methods*