title: Glutathione S-transferase M1 (GSTM1) polymorphism is associated with atopic dermatitis susceptibility in a Korean population.
abstract: Atopic dermatitis (AD) is a chronic pruritic skin condition affecting as much as 15% of children in industrialized countries. While the underlying pathophysiology of AD is not entirely understood, several studies have suggested that AD may mediated by oxidative stress. Glutathione S-transferases (GSTs) are a class of polymorphic enzymes that function to protect against oxidative stress. To identify any possible associations between GSTs polymorphisms and AD susceptibility, the prevalence of two specific polymorphisms -GSTM1 and GSTT1 (homozygous deletion vs. undeleted) - were quantified by multiplex PCR in 145 patients with AD and 267 healthy controls. In individuals with AD, GSTM1/GSTT1 polymorphisms were compared with family history of AD, age of disease onset, disease severity [per SCORing Atopic Dermatitis (SCORAD)], serum IgE level and presence of other allergic diseases. While the GSTM1-null genotype was found to be significantly associated with AD (P = 0.033, OR = 1.579, 95% CI = 1.037-2.403), the correlation between the GSTT1-null genotype and AD did not reach statistical significance (P = 0.577, OR = 1.125, 95% CI = 0.744-1.702). The GSTM1-null genotype was also found to be significantly associated with a childhood onset of AD, the absence of other allergic diseases, and a family history of AD. In combination, these results suggest that GSTM1 is associated with AD susceptibility in Korean subjects.
authors.affiliation: Department of Dermatology, School of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Korea.
authors.forename: H-R
authors.initials: HR
authors.lastname: Cho
authors.forename: Y-K
authors.initials: YK
authors.lastname: Uhm
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: J-Y
authors.initials: JY
authors.lastname: Ban
authors.forename: J-H
authors.initials: JH
authors.lastname: Chung
authors.forename: S-V
authors.initials: SV
authors.lastname: Yim
authors.forename: B-K
authors.initials: BK
authors.lastname: Choi
authors.forename: M-H
authors.initials: MH
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003876:Dermatitis, Atopic / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D005982:Glutathione Transferase; D007073:Immunoglobulin E; C413545:glutathione S-transferase T1