title: Patient-specific computational hemodynamics of intracranial aneurysms from 3D rotational angiography and CT angiography: an in vivo reproducibility study.
abstract: OBJECTIVE
  Patient-specific simulations of the hemodynamics in intracranial aneurysms can be constructed by using image-based vascular models and CFD techniques. This work evaluates the impact of the choice of imaging technique on these simulations.
  
  
  METHODS
  Ten aneurysms, imaged with 3DRA and CTA, were analyzed to assess the reproducibility of geometric and hemodynamic variables across the 2 modalities.
  
  
  RESULTS
  Compared with 3DRA models, we found that CTA models often had larger aneurysm necks (P = .05) and that most of the smallest vessels (between 0.7 and 1.0 mm in diameter) could not be reconstructed successfully with CTA. With respect to the values measured in the 3DRA models, the flow rate differed by 14.1 ± 2.8% (mean ± SE) just proximal to the aneurysm and 33.9 ± 7.6% at the aneurysm neck. The mean WSS on the aneurysm differed by 44.2 ± 6.0%. Even when normalized to the parent vessel WSS, a difference of 31.4 ± 9.9% remained, with the normalized WSS in most cases being larger in the CTA model (P = .04). Despite these substantial differences, excellent agreement (κ ≥ 0.9) was found for qualitative variables that describe the flow field, such as the structure of the flow pattern and the flow complexity.
  
  
  CONCLUSIONS
  Although relatively large differences were found for all evaluated quantitative hemodynamic variables, the main flow characteristics were reproduced across imaging modalities.
authors.affiliation: Center for Computational Imaging and Simulation Technologies in Biomedicine, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: A J
authors.initials: AJ
authors.lastname: Geers
authors.forename: I
authors.initials: I
authors.lastname: Larrabide
authors.forename: A G
authors.initials: AG
authors.lastname: Radaelli
authors.forename: H
authors.initials: H
authors.lastname: Bogunovic
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: H A F
authors.initials: HA
authors.lastname: Gratama van Andel
authors.forename: C B
authors.initials: CB
authors.lastname: Majoie
authors.forename: E
authors.initials: E
authors.lastname: VanBavel
authors.forename: A F
authors.initials: AF
authors.lastname: Frangi
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012399:Rotation; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*