title: Copper(I)-mediated preparation of new pyrano[3',4':4,5]imidazo[1,2-a]pyridin-1-one compounds under mild palladium-free conditions.
abstract: A general and efficient Cu(I)-mediated cross-coupling and heterocyclization reaction of 3-iodoimidazo[1,2-a]pyridine-2-carboxylic acid, and terminal alkynes was developed under very mild conditions. This method allows the introduction in one pot of a third ring fused in positions 2 and 3 of the imidazo[1,2-a]pyridine core with reasonable yields and total regioselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.
authors.affiliation: Faculté des Sciences, Laboratoire de PhysicoChimie des Matériaux et Biomolécules EA 4244, Université François Rabelais, Parc de Grandmont, 37200 Tours, France.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Bahlaouan
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abarbri
authors.forename: Alain
authors.initials: A
authors.lastname: Duchêne
authors.forename: Jérôme
authors.initials: J
authors.lastname: Thibonnet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Henry
authors.forename: Cécile
authors.initials: C
authors.lastname: Enguehard-Gueiffier
authors.forename: Alain
authors.initials: A
authors.lastname: Gueiffier
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D011728:Pyridones; C557178:pyrano(3',4'-4,5)imidazo(1,2-a)pyridin-1-one; D010165:Palladium; D003300:Copper