title: Blood lipids and adipokines concentrations during a 6-month nutritional and physical activity intervention for metabolic syndrome treatment.
abstract: BACKGROUND
  To report changes in body weight, total and central fat mass, metabolic, hormonal and inflammatory parameters in overweight people who participated in a six months weight loss intervention associating diet management and exercise.
  
  
  METHODS
  Fourteen subjects (10 M, 4 F, mean age 62.9 ± 6.9 years, BMI 30.4+/- 3.8 kg/m2) presenting the characteristics of the Metabolic Syndrome (MS) were included in the survey. They followed a three weeks (D0 to D20) cure in a medical establishment and a six months (D20 to M3 and M6) follow up at home. During the cure, they receive a balanced diet corresponding to 500 Kcal deficit vs their daily energy expenditure (DEE) and they exercised 2 to 3 hours per day.At D0, D20, M3 and M6, body composition (lean mass, total and central fat mass) was analyzed with DEXA, blood pressure was taken and blood was collected to evaluate glycaemia, triglycerides, total, LDL and HDL cholesterol, insulin, leptin and adiponectin levels, CRP and pro-inflammatory interleukines IL1, IL.6 and TNFalpha.
  
  
  RESULTS
  All parameters listed above except the cytokine were improved at D20, so that 4 subjects among 14 still presented the MS. After returning to home, these parameters remained stable.
  
  
  CONCLUSIONS
  The efficacy of therapeutic lifestyle modifications with education and exercise and diet was demonstrated, but the compliance to the new healthy lifestyle initiated during the cure was not optimal.
authors.affiliation: Clermont University Blaise Pascal, BAPS, EA 3533, BP 10448, F 63000 Clermont-Ferrand, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dutheil
authors.forename: Bruno
authors.initials: B
authors.lastname: Lesourd
authors.forename: Daniel
authors.initials: D
authors.lastname: Courteix
authors.forename: Robert
authors.initials: R
authors.lastname: Chapier
authors.forename: Eric
authors.initials: E
authors.lastname: Doré
authors.forename: Gérard
authors.initials: G
authors.lastname: Lac
mesh_terms: D015502:Absorptiometry, Photon; D054392:Adipokines / Q000097:blood; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D016207:Cytokines / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008019:Life Style; D008074:Lipoproteins / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D016207:Cytokines; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides