title: A finite element method approach for the mechanobiological modeling of the osseointegration of a dental implant.
abstract: The aim of this paper is to introduce a new mathematical model using a mechanobiological approach describing the process of osseointegration at the bone-dental implant interface in terms of biological and mechanical factors and the implant surface. The model has been computationally implemented by using the finite element method. The results show the spatial-temporal patterns distribution at the bone-dental implant interface and demonstrate the ability of the model to reproduce features of the wound healing process such as blood clotting, osteogenic cell migration, granulation tissue formation, collagen-like matrix displacements and new osteoid formation. The model might be used as a methodological basis for designing a dental tool useful to predict the degree of osseointegration of dental implants and subsequent formulation of mathematical models associated with different types of bone injuries and different types of implantable devices.
authors.affiliation: Group of Mathematical Modeling and Numerical Methods GNUM-UN, Faculty of Engineering, National University of Colombia, Bogota, Colombia. jcvanegasa@unal.edu.co
authors.forename: J C
authors.initials: JC
authors.lastname: Vanegas-Acosta
authors.forename: N S
authors.initials: NS
authors.lastname: Landinez P
authors.forename: D A
authors.initials: DA
authors.lastname: Garzón-Alvarado
authors.forename: M C
authors.initials: MC
authors.lastname: Casale R
mesh_terms: D003198:Computer Simulation; D015921:Dental Implants; D017267:Dental Prosthesis Design / Q000379:methods*; D005337:Fibrin / Q000378:metabolism; D020342:Finite Element Analysis; D016348:Osseointegration / Q000502:physiology*; D013314:Stress, Mechanical; D013917:Thrombin / Q000378:metabolism
chemical_list: D015921:Dental Implants; D005337:Fibrin; D013917:Thrombin