title: [The autonomic nervous system involved in regulation of immune function in rats during hypoxia].
abstract: OBJECTIVE
  To study of autonomic nervous system modulation of lymphocyte proliferation during hypoxia.
  
  
  METHODS
  Rats were exposed to 5 km and 7 km altitude in a hypobaric chamber for 24 h or 48 h, the effect of autonomic nervous system on mitogen-induced spleen lymphocyte response to the acute hypoxia was investigated.
  
  
  RESULTS
  When rats were exposed to 5 km altitude for 24 h, which inhibited spleen T lymphocyte proliferation induced by concanavalin (Con A), but the action was abolished through peripheral sympathetic-destroyed. When mouse were exposed anoxia environment at 0.07 MPa for 10 min, the norepinephrine and epinephrine in plasma were increased markedly. T cells of rats were in vitro incubated simultaneously with ACh showing a concentration dependent enhancement of T cell proliferation. The plasma levels of ACh were decreased after rats were exposed to 5 km for 24 h.
  
  
  CONCLUSIONS
  Autonomic nervous system was involved in the regulation of immune function in rats during hypoxia.
authors.affiliation: Department of Biological Science and Medical Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Bai
authors.forename: J Z
authors.initials: JZ
authors.lastname: Du
authors.forename: X X
authors.initials: XX
authors.lastname: Zeng
mesh_terms: D000531:Altitude; D000818:Animals; D001341:Autonomic Nervous System / Q000276:immunology* / Q000502:physiology; D004837:Epinephrine / Q000097:blood; D000860:Hypoxia / Q000276:immunology* / Q000503:physiopathology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D009638:Norepinephrine; D004837:Epinephrine