title: Comparison of Chlorella vulgaris dressing and sodium alginate dressing: an experimental study in rats.
abstract: OBJECTIVE
  Chlorella vulgaris (CV) is a green microalgae enriched with nutrients, vitamins, minerals and chlorophyll. The aim of our study was to evaluate the potential wound healing effects of CV as a dressing while comparing it to sodium alginate dressing.
  
  
  METHODS
  Fifteen Sprague-Dawley rats were divided into three groups consisting of control (normal-wound with no dressing), CV and sodium alginate dressings. Wound was created on the dorsal surface of rats using a 6-mm sterilized punch biopsy. The wounds were examined on days 3, 6, 9 and 12 for dryness, exudation, contraction, period of epithelialization, complete wound closure and scar formation. All rats were sacrificed on day 12 and the granulation tissue formed on the wound was excised for the histological examination using Hematoxylin and Eosin stain (H&E).
  
  
  RESULTS
  The wound's size treated with CV dressing was significantly reduced (p<0.05) compared to the control and sodium alginate treated wounds. H&E staining showed that CV dressing minimized the formation of scar tissue during the healing process. Although there was no statistically significant difference in the complete wound closure and period of epithelialization among the groups, a significant difference was observed regarding the dryness, exudation and scar formation in the wound.
  
  
  CONCLUSIONS
  CV extract can be used as an effective supplement for wound dressing.
authors.affiliation: Departments of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.
authors.forename: N
authors.initials: N
authors.lastname: Zailan
authors.forename: A H
authors.initials: AH
authors.lastname: Abdul Rashid
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.forename: N A
authors.initials: NA
authors.lastname: Abdul Mokti
authors.forename: J
authors.initials: J
authors.lastname: Hassan Basri
authors.forename: S L
authors.initials: SL
authors.lastname: Teoh
authors.forename: W Z
authors.initials: WZ
authors.lastname: Wan Ngah
authors.forename: Y A
authors.initials: YA
authors.lastname: Mohd Yusof
mesh_terms: D000464:Alginates / Q000494:pharmacology; D000818:Animals; D001684:Biological Dressings; D048408:Chlorella vulgaris; D002921:Cicatrix / Q000517:prevention & control; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D005260:Female; D020723:Glucuronic Acid / Q000494:pharmacology; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D006603:Hexuronic Acids / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid