title: Alcohol seeking and consumption in the NVHL neurodevelopmental rat model of schizophrenia.
abstract: Alcohol abuse in schizophrenia exceeds rates in the general population and worsens illness outcomes. Neonatal ventral hippocampal lesion (NVHL) rats model multiple schizophrenia dimensions including addiction vulnerability. This study compared NVHL vs. SHAM-controls in operant alcohol seeking and consumption. NVHLs enhanced consumption of combined ethanol/sucrose solution but neither ethanol or sucrose only solutions, consistent with increased vulnerability specific to carbohydrate-laden alcohol beverages typically consumed in early stages of human alcoholism.
authors.affiliation: Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA. saberg@iupui.edu
authors.forename: S A
authors.initials: SA
authors.lastname: Berg
authors.forename: C L
authors.initials: CL
authors.lastname: Czachowski
authors.forename: R Andrew
authors.initials: RA
authors.lastname: Chambers
mesh_terms: D000428:Alcohol Drinking / Q000503:physiopathology* / Q000523:psychology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D058999:Drug-Seeking Behavior / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology