title: The development of vaccine viruses against pandemic A(H1N1) influenza.
abstract: Wild type human influenza viruses do not usually grow well in embryonated hens' eggs, the substrate of choice for the production of inactivated influenza vaccine, and vaccine viruses need to be developed specifically for this purpose. In the event of a pandemic of influenza, vaccine viruses need to be created with utmost speed. At the onset of the current A(H1N1) pandemic in April 2009, a network of laboratories began a race against time to develop suitable candidate vaccine viruses. Two approaches were followed, the classical reassortment approach and the more recent reverse genetics approach. This report describes the development and the characteristics of current pandemic H1N1 candidate vaccine viruses.
authors.affiliation: Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK. jim.robertson@nibsc.hpa.org.uk
authors.forename: James S
authors.initials: JS
authors.lastname: Robertson
authors.forename: Carolyn
authors.initials: C
authors.lastname: Nicolson
authors.forename: Ruth
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authors.lastname: Harvey
authors.forename: Rachel
authors.initials: R
authors.lastname: Johnson
authors.forename: Diane
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authors.lastname: Major
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authors.lastname: Guilfoyle
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authors.lastname: Roseby
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authors.lastname: Newman
authors.forename: Rebecca
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authors.lastname: Collin
authors.forename: Chantal
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authors.forename: Othmar G
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authors.lastname: Engelhardt
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authors.forename: Ramanunninair
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authors.forename: Jeanmarie
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authors.lastname: Silverman
authors.forename: Rene
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authors.lastname: Devis
authors.forename: Doris
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authors.lastname: Bucher
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authors.lastname: Verity
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authors.lastname: Agius
authors.forename: Sarina
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authors.lastname: Camuglia
authors.forename: Chi
authors.initials: C
authors.lastname: Ong
authors.forename: Steven
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authors.lastname: Rockman
authors.forename: Anne
authors.initials: A
authors.lastname: Curtis
authors.forename: Peter
authors.initials: P
authors.lastname: Schoofs
authors.forename: Olga
authors.initials: O
authors.lastname: Zoueva
authors.forename: Hang
authors.initials: H
authors.lastname: Xie
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Zhengshi
authors.initials: Z
authors.lastname: Lin
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Ye
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Chen
authors.forename: Eduardo
authors.initials: E
authors.lastname: O'Neill
authors.forename: Amanda
authors.initials: A
authors.lastname: Balish
authors.forename: Aleksandr S
authors.initials: AS
authors.lastname: Lipatov
authors.forename: Zhu
authors.initials: Z
authors.lastname: Guo
authors.forename: Irina
authors.initials: I
authors.lastname: Isakova
authors.forename: Charles T
authors.initials: CT
authors.lastname: Davis
authors.forename: Pierre
authors.initials: P
authors.lastname: Rivailler
authors.forename: Kortney M
authors.initials: KM
authors.lastname: Gustin
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Belser
authors.forename: Taronna R
authors.initials: TR
authors.lastname: Maines
authors.forename: Terrence M
authors.initials: TM
authors.lastname: Tumpey
authors.forename: Xiyan
authors.initials: X
authors.lastname: Xu
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Katz
authors.forename: Alexander
authors.initials: A
authors.lastname: Klimov
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
authors.forename: Ruben O
authors.initials: RO
authors.lastname: Donis
mesh_terms: D000818:Animals; D002460:Cell Line; D004285:Dogs; D055808:Drug Discovery / Q000379:methods*; D005289:Ferrets; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology* / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000138:chemical synthesis / Q000276:immunology / Q000627:therapeutic use*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control*; D058873:Pandemics / Q000517:prevention & control*
chemical_list: D007252:Influenza Vaccines