title: [Effects of taurine on NOS activity in myocardium and plasma of hemorrhagic shock resuscitation in rabbits].
abstract: OBJECTIVE
  To investigate the effect of taurine on nitric oxide synthase (NOS) activity and nitric oxide products (NO2 /NO3 ) content in myocardium and plasma during shock resuscitation.
  
  
  METHODS
  Twenty-four rabbits were divided randomly into 3 groups (n=8): control group, shock group, taurine group. The model of hemorrhagic shock resuscitation was used. The activities of nitric oxide synthase (NOS), lactate dehydrogenase (LDH) and the contents of nitric oxide products (NO2- /NO3-) in plasma were observed before shock and shock 1.5 hours, after resuscitation 1 hour, 2 hours and 3 hours. The activities of NOS and the contents of NO2-/NO3- in myocardium homogenate were measured after resuscitation 3 hours. Meanwhile, pathologic samples treated routinely.
  
  
  RESULTS
  (1) During resuscitation, the activities of NOS, LDH and the contents of NO2- /NO3- in plasma of shock group were significantly higher than that of before shock and shock 1.5 hours (P < 0.01). (2) After resuscitation 3 hours, the activity of NOS and the contents of NO2- / NO3 in myocardium of shock group were significantly higher than that of control group (P < 0.01). The cardiac myocyte appeared edema, fatty degeneration. (3) All the changes of above mentioned could be attenuated by intravenous injection taurine (40 mg/kg) (P < 0.01).
  
  
  CONCLUSIONS
  These results suggest that the NOS activation and NO release may mediated myocardium injury induced by shock resuscitation, taurine can ameliorate the myocardium injury, which may be related to decreasing the generation of NO.
authors.affiliation: Department of Pathophysiology, Medical College of Shihezi University, Shihezi 832002, China.
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.forename: Feng-mei
authors.initials: FM
authors.lastname: Deng
authors.forename: Hua
authors.initials: H
authors.lastname: Zhong
authors.forename: Cheng-jing
authors.initials: CJ
authors.lastname: Chu
authors.forename: Zhi-ping
authors.initials: ZP
authors.lastname: Sun
mesh_terms: D000818:Animals; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010949:Plasma / Q000378:metabolism*; D011817:Rabbits; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000097:blood / Q000378:metabolism*; D013654:Taurine / Q000494:pharmacology*
chemical_list: D013654:Taurine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase