title: [Relationship between genetic polymorphism of ERCC1 and susceptibility to liver cancer].
abstract: OBJECTIVE
  To investigate the association between genetic polymorphisms of ERCC1-C8092A and susceptibility to liver cancer, as well as the gene-environmental interaction on the etiology of liver cancer in Fuzhou.
  
  
  METHODS
  A case-control study was conducted to collect the information on environmental exposure while genetic polymorphism of ERCC1 was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. General relative risk regression models were further applied to fit the interaction between genetic polymorphisms of ERCC1-C8092A and the environmental factors of liver cancer.
  
  
  RESULTS
  ERCC1-C8092A variant genotypes were associated with significant increasing risk of liver cancer adjusted odds ratio (OR = 3.789, 95%CI: 2.792 - 5.142), compared to the wild-type homozygote. Data from the analysis of interaction showed that genetic polymorphism of ERCC1-8092A appeared super-additive interaction with drinking pond-ditch or with hepatitis B, and super-multiplicative interaction with eating moldy food.
  
  
  CONCLUSIONS
  The point mutation in ERCC1-8092A was possibly susceptible to liver cancer, and related synergistically with other risk factors in hepatocelluar carcinogenesis in Fuzhou.
authors.affiliation: Epidemiology and Statistics Departmen, Fujian Medical University, Fuzhou 350004, China. Email: hzj99955888@126.com.
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Hu
authors.forename: Jin-Fa
authors.initials: JF
authors.lastname: Xue
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Zhang
authors.forename: Xi-Shun
authors.initials: XS
authors.lastname: Shi
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms; D011110:Polymorphism, Genetic