title: A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx.
abstract: A new triterpene, 21-O-senecioyl-R(1)-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on a model of CaCl(2)-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of liriodendrin from 87.5% to 25%. The antiarrhythmic effect of liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, liriodendrin may be a potent suppressor of CaCl(2)-induced arrhythmias.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Feng
authors.forename: Bo-Gang
authors.initials: BG
authors.lastname: Li
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Gao
authors.forename: Hua-Yi
authors.initials: HY
authors.lastname: Qi
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D005663:Furans / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D008297:Male; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley; D019685:Rosales; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000188:drug therapy*; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D005663:Furans; D005960:Glucosides; D010936:Plant Extracts; D014315:Triterpenes; C068512:liriodendrin; D014700:Verapamil