title: [Galactosemia associated with Rogers syndrome in a 10-month-old infant].
abstract: Galactosemia and congenital Rogers syndrome or thiamine-responsive megaloblastic anemia are 2 rare inherited metabolic diseases. The combination of the 2 diseases has never been reported in the literature. We describe the case of an infant followed for congenital galactosemia since the age of 8 days, with thiamine-responsive megaloblastic anemia diagnosed at the age of 10 months. Galactosemia's symptoms occur in the first 2 weeks of life with severe liver disease. Total eviction of the galactose allows complete regression and prevention of early symptoms but does not prevent late complications. Rogers syndrome associates megaloblastic anemia, deafness, and diabetes mellitus that begin in childhood. Supplementation with thiamine allows regression of anemia and prevents the onset of diabetes at least until adolescence.
authors.affiliation: Pôle de pédiatrie, hôpital de l'Archet-II, 151 route de Saint-Antoine-de-Ginestière, Nice cedex 3, France. letiziacrouzet@yahoo.fr
authors.forename: L
authors.initials: L
authors.lastname: Crouzet-Ozenda Luci
authors.forename: S
authors.initials: S
authors.lastname: De Smet
authors.forename: F
authors.initials: F
authors.lastname: Monpoux
authors.forename: C
authors.initials: C
authors.lastname: Ferrero-Vacher
authors.forename: F
authors.initials: F
authors.lastname: Giuliano
authors.forename: N
authors.initials: N
authors.lastname: Sirvent
mesh_terms: D000749:Anemia, Megaloblastic / Q000150:complications; D003920:Diabetes Mellitus; D005260:Female; D005693:Galactosemias / Q000150:complications*; D006319:Hearing Loss, Sensorineural / Q000150:complications; D006801:Humans; D007223:Infant; D007655:Ketoglutarate Dehydrogenase Complex / Q000172:deficiency; D013832:Thiamine Deficiency / Q000151:congenital
chemical_list: D007655:Ketoglutarate Dehydrogenase Complex