title: Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10.
abstract: OBJECTIVE: to map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. METHODS: genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. RESULTS: 1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area.
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
authors.forename: Qing Yin
authors.initials: QY
authors.lastname: Zheng
authors.forename: Belinda S
authors.initials: BS
authors.lastname: Harris
authors.forename: Patricia F
authors.initials: PF
authors.lastname: Ward-Bailey
authors.forename: Heping
authors.initials: H
authors.lastname: Yu
authors.forename: Roderick T
authors.initials: RT
authors.lastname: Bronson
authors.forename: Muriel T
authors.initials: MT
authors.lastname: Davisson
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Johnson