title: Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study.
abstract: OBJECTIVE
  Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.
  
  
  METHODS
  Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case-cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.
  
  
  RESULTS
  No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates = 0.29). No interaction with meat intake was found (P value for interaction = 0.55).
  
  
  CONCLUSIONS
  The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.
authors.affiliation: Medical Department, Viborg Regional Hospital, Denmark. vibeke.andersen@viborg.rm.dk
authors.forename: Vibeke
authors.initials: V
authors.lastname: Andersen
authors.forename: Jane
authors.initials: J
authors.lastname: Christensen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Ulla
authors.initials: U
authors.lastname: Vogel
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D003718:Denmark / Q000453:epidemiology; D005247:Feeding Behavior; D005260:Female; D006418:Heme / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008460:Meat / Q000009:adverse effects / Q000706:statistics & numerical data; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012306:Risk
chemical_list: D006418:Heme; D051547:Heme Oxygenase-1