title: Stereotactic body radiotherapy (SBRT): Technological innovation and application in gynecologic oncology.
abstract: OBJECTIVE
  Stereotactic body radiotherapy (SBRT) is a novel form of noninvasive, highly conformal radiation treatment that delivers a high dose to tumor. The advantage of the technique resides in its ability to provide a high dose to tumor but spare normal tissues to an extent not previously possible. In this paper we will provide an introduction and review of this technology with regard to its use in gynecologic malignancies. Preliminary results from our experience are presented for the purpose of illustrating the range of SBRT applications in gynecologic oncology.
  
  
  METHODS
  A comprehensive literature review was conducted and our experience from the past three years was reviewed.
  
  
  RESULTS
  Six case series are published that report results of SBRT for gynecologic malignancies. Sixteen gynecologic patients have been treated with SBRT at our institution. Treatment sites include pelvic and periaortic nodes (9 patients), oligometastatic disease (2), and cervical or endometrial primary tumors when other conventional external radiation or brachytherapy techniques were unsuitable (5). Preliminary follow-up at a median of 11 months (range, 0.3-33 months) demonstrates 79% locoregional control, 43% distant failure, and 50% overall survival.
  
  
  CONCLUSIONS
  SBRT boosts to macroscopic periaortic node recurrences and other sites seem to provide local control and a possibility of long-term disease-free survival in carefully selected patients. Previously this had been difficult to achieve with conventional radiotherapy because of the proximity of periaortic nodes to small bowel. SBRT also offers a novel approach for minimally invasive treatment in the management of gynecological cancer where current surgical and radiotherapy techniques are unsuitable.
authors.affiliation: Department of Radiation Oncology, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27514, USA. daniel.higginson@gmail.com
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Higginson
authors.forename: David E
authors.initials: DE
authors.lastname: Morris
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Jones
authors.forename: Daniel
authors.initials: D
authors.lastname: Clarke-Pearson
authors.forename: Mahesh A
authors.initials: MA
authors.lastname: Varia
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016634:Radiosurgery / Q000379:methods*; D012371:Robotics