title: Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma: a meta-analysis.
abstract: BACKGROUND
  HLA-DRB1 allele polymorphisms have been reported to be associated with hepatocellular carcinoma susceptibility, but the results of these previous studies have been inconsistent. The purpose of the present study was to explore whether specific HLA-DRB1 alleles (DRB1*07, DRB1*12, DRB1*15) confer susceptibility to hepatocellular carcinoma.
  
  
  METHODS
  Case-control studies on HLA-DRB1 alleles association with HCC were searched up to January 2010 through a systematic review of the literature. The odds ratios (ORs) of HLA-DRB1 allele distributions in patients with hepatocellular carcinoma were analyzed against healthy controls. The meta-analysis software REVMAN 5.0 was applied for investigating heterogeneity among individual studies and for summarizing all the studies. Meta-analysis was performed using fixed-effect or random-effect methods, depending on absence or presence of significant heterogeneity.
  
  
  RESULTS
  Eight case-control studies were included in the final analysis. Among the 3 HLA-DRB1 alleles studied, DRB1*07 and DRB1*12 were significantly associated with the risk of HCC in the whole populations (OR = 1.65, 95% CI: 1.08-2.51, P = 0.02 and OR = 1.59, 95% CI: 1.09-2.32, P = 0.02, respectively). No significant association was established for DRB1*15 allele with HCC in the whole populations. Subgroup analysis by ethnicity showed that DRB1*07, DRB1*12 and DRB1*15 alleles significantly increased the risk of hepatocellular carcinoma in Asians (OR = 2.10, 95% CI: 1.06-4.14, P = 0.03; OR = 1.73, 95% CI: 1.17-2.57, P = 0.006 and OR = 2.88, 95%CI: 1.77-4.69, P <0.001, respectively).
  
  
  CONCLUSIONS
  These results support the hypothesis that specific HLA-DRB1 alleles might influence the susceptibility of hepatocellular carcinoma. Large, multi-ethnic confirmatory and well designed studies are needed to determine the host genetic determinants of hepatocellular carcinoma.
authors.affiliation: Medical College of Qingdao University, Shandong Province, China.
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Lin
authors.forename: Yong-Ning
authors.initials: YN
authors.lastname: Xin
authors.forename: Quan-Jiang
authors.initials: QJ
authors.lastname: Dong
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Zhan
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Xuan
mesh_terms: D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains