title: Modulation of programmed cell death pathways by the hepatitis C virus.
abstract: Hepatitis C virus (HCV), a positive stranded RNA virus of the family Flaviviridae, is the major cause of non-A, non-B hepatitis worldwide. The HCV genome encodes a precursor polyprotein of ~ 3,000 amino acids that is processed co-translationally and post-translationally to give rise to viral structural and non-structural proteins. Nearly all of these viral proteins have been shown to modulate cell death via various mechanisms. In addition, studies using the replicon and recombinant HCV cell culture systems have yield important insights into the modulation of programmed cell death by HCV replication. Here, we summarize current knowledge on the modulation of apoptosis and other programmed cell death pathways by the HCV in these cell culture systems.
authors.affiliation: Collaborative Anti-Viral Research Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.
authors.forename: Jude Juventus
authors.initials: JJ
authors.lastname: Aweya
authors.forename: Yee-Joo
authors.initials: YJ
authors.lastname: Tan
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002352:Carrier Proteins / Q000494:pharmacology; D016174:Hepacivirus / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D014758:Viral Core Proteins / Q000494:pharmacology; D014759:Viral Envelope Proteins / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000494:pharmacology; D014764:Viral Proteins / Q000494:pharmacology; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; D000086082:Viroporin Proteins; D012324:RNA-Dependent RNA Polymerase
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C087035:E1 protein, Hepatitis C virus; C097010:NS2 protein, Hepatitis C virus; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C455041:NS4A cofactor peptide, Hepatitis C virus; C088369:p7 protein, Hepatitis C virus; D000086082:Viroporin Proteins; C091015:glycoprotein E2, Hepatitis C virus; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase