title: CT color mapping of the arterial enhancement fraction of VX2 carcinoma implanted in rabbit liver: comparison with perfusion CT.
abstract: OBJECTIVE
  The purpose of this study was to compare the arterial enhancement fraction (AEF) calculated at multiphasic liver CT with the hepatic perfusion index (HPI) measured with cine mode perfusion CT.
  
  
  METHODS
  Cine mode perfusion CT was performed after VX2 tumor implantation in the livers of 10 rabbits. HPI and its color map were obtained with a computer application. With raw data from cine mode perfusion CT, images were extracted in the unenhanced, arterial, and portal venous phases to simulate multiphasic liver CT. On the basis of simulated multiphasic CT images, the AEF color map was obtained with prototype software. HPI and AEF were compared for the same regions of interest in the liver parenchyma, whole liver tumor, and viable tumor portion.
  
  
  RESULTS
  In the liver parenchyma, the mean HPI was 23.3% ± 2.6% (SD) and the AEF 24.4% ± 2.8%; in whole liver tumor, 73.4% ± 9.5% and 78.4% ± 10.5%; and in the viable tumor portion, 78.0% ± 7.7% and 78.3% ± 7.5%. The differences were not statistically significant (p > 0.05, Wilcoxon's signed rank test). Measurement agreement between the two parameters was moderate (Bland-Altman 95% limits of agreement, -14.9% and 19.2%), but there was a strong positive correlation between AEF and HPI (within-subject r = 0.91, p < 0.001). Functional maps of HPI and AEF correlated with the histologic findings.
  
  
  CONCLUSIONS
  AEF calculated from simulated multiphasic liver CT images correlates strongly with HPI obtained at cine mode perfusion CT. Further study of the AEF is warranted to explore its value in providing hepatic perfusion information without additional radiation exposure.
authors.affiliation: Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, 28 Yeongon-dong, Jongno-gu, Seoul 110-744, Korea.
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Kim
authors.forename: Ernst
authors.initials: E
authors.lastname: Klotz
authors.forename: Hyo-Cheol
authors.initials: HC
authors.lastname: Kim
authors.forename: Joon Koo
authors.initials: JK
authors.lastname: Han
authors.forename: Byung Ihn
authors.initials: BI
authors.lastname: Choi
mesh_terms: D000818:Animals; D003287:Contrast Media; D007150:Immunohistochemistry; D016014:Linear Models; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D011817:Rabbits; D012984:Software; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media