title: Synthesis and characterization of small circular double-stranded RNAs.
abstract: Small circular double-stranded RNAs (dsRNAs) were synthesized. The structural analysis by atomic force microscopy gave direct images for the interpretation of the structural strain present in circular dsRNAs. Finally, we demonstrated that circular dsRNA caused RNAi effect in cells.
authors.affiliation: Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Abe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abe
authors.forename: Takahito
authors.initials: T
authors.lastname: Ohshiro
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Mizuo
authors.initials: M
authors.lastname: Maeda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000818:Animals; D001483:Base Sequence; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D041681:NIH 3T3 Cells; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry* / Q000235:genetics; D034622:RNA Interference; D000079962:RNA, Circular; D012330:RNA, Double-Stranded / Q000138:chemical synthesis / Q000737:chemistry* / Q000235:genetics; D014162:Transfection
chemical_list: D000079962:RNA, Circular; D012330:RNA, Double-Stranded; D012313:RNA