title: [Pregabalin and postoperative hyperalgesia. A review].
abstract: Numerous studies support the theory that pregabalin causes an antihyperalgesic effect, which could be potentially beneficial in a perioperative setting. By binding to calcium channels pregabalin reduces the release of excitatory neurotransmitters and therefore inhibits central sensitization. Animal studies clearly demonstrated the antihyperalgesic potency of pregabalin but human experiments are, however, inconclusive. Clinical studies with quantitative sensory testing have not yet been published. Although strongly supported by theoretical considerations the routine preoperative application of pregabalin for the prevention of hyperalgesia cannot be recommended due to the lack of clinical studies. Future studies should incorporate secondary hyperalgesia and allodynia as primary parameters.
authors.affiliation: Universitätsklinik für Anästhesiologie und Intensivmedizin, Medizinische Universität Graz, Auenbruggerplatz 29, 8036 Graz, Austria.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lederer
authors.forename: H
authors.initials: H
authors.lastname: Bornemann-Cimenti
authors.forename: M
authors.initials: M
authors.lastname: Wejbora
authors.forename: C
authors.initials: C
authors.lastname: Kern-Pirsch
authors.forename: K
authors.initials: K
authors.lastname: Michaeli
authors.forename: A
authors.initials: A
authors.lastname: Sandner-Kiesling
mesh_terms: D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy*; D000069583:Pregabalin; D011292:Premedication; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D015220:Calcium Channels; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid