title: [Ozone therapy combined with sulfasalazine delivered via a colon therapy system for treatment of ulcerative colitis].
abstract: OBJECTIVE
  To assess the therapeutic effect of ozone therapy combined with sulfasalazine sulfasalazine delivered via a colon therapy system in the treatment of distal ulcerative colitis.
  
  
  METHODS
  This prospective randomized controlled clinical trial involved 54 patients with mild to moderate active distal ulcerative colitis, who were randomize into 3 groups in accordance with the inclusion criteria (n=18). Each group was given sulfasalazine at the daily dose of 2 g, and in colon therapy group and ozone therapy plus sulfasalazine therapy group, sulfasalazine was delivered via a colon therapy system on a daily basis; the control group received sulfasalazine via retention enema only. At 0, 2, and 4 weeks of the treatment, colonoscopy was performed to evaluate the disease activity, and biopsy samples were obtained at 0 and 4 weeks for histological examination.
  
  
  RESULTS
  In comparison with colon therapy group and control group, ozone therapy plus colon therapy resulted in more rapid alleviation of the clinical symptoms and better histological improvement without any adverse effects.
  
  
  CONCLUSIONS
  Ozone therapy combined with sulfasalazine delivered via a colon therapy system is feasible and effective for treatment of ulcerative colitis.
authors.affiliation: Department of Gastroenterology, Guangxi, China. gytools@163.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Geng
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.forename: Li-qiong
authors.initials: LQ
authors.lastname: Peng
authors.forename: Zhong-hui
authors.initials: ZH
authors.lastname: Liang
mesh_terms: D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000627:therapeutic use*; D011446:Prospective Studies; D012460:Sulfasalazine / Q000008:administration & dosage* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D012460:Sulfasalazine; D010126:Ozone