title: Nasopharyngeal cancer (NPC) around the Mediterranean area: standard of care.
abstract: Mediterranean area (MA) represents a zone of intermediate incidence (1-5/100,000) for NPC, the highest frequency being observed in North Africa (NA) where it is characterized by a bimodal age repartition due to a first adolescence peak. In MA and NA, NPC remain diagnosed at advanced stages which impact poorly on overall and disease-free survival. It's therapy in MA followed the progresses and standardisation of protocols, based on concomitant chemoradiotherapy (CCRT) alone or preceded by induction chemotherapy (ICT) in advanced (N2-3, T3-4) stages, while localized cases are managed irradiation alone. NPC overall an disease-free survival improved, due to the use of combined chemo and radiotherapy.
authors.affiliation: Department of Medical Oncology, Institut Salah Azaiz, Tunis, Tunisia. sarroura2000@yahoo.fr
authors.forename: Hamouda
authors.initials: H
authors.lastname: Boussen
authors.forename: Lilia
authors.initials: L
authors.lastname: Ghorbal
authors.forename: Lejri
authors.initials: L
authors.lastname: Naouel
authors.forename: Noureddine
authors.initials: N
authors.lastname: Bouaouina
authors.forename: Said
authors.initials: S
authors.lastname: Gritli
authors.forename: Farouk
authors.initials: F
authors.lastname: Benna
authors.forename: Jamel
authors.initials: J
authors.lastname: Daoud
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods; D006801:Humans; D019083:Mediterranean Region / Q000453:epidemiology; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy*; D009305:Nasopharynx / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D059039:Standard of Care
chemical_list: D000970:Antineoplastic Agents