title: Role of cereal type and processing in whole grain in vivo protection from oxidative stress.
abstract: The reduced risk of chronic diseases related to whole grain consumption is in part attributed to their high antioxidant content. Many studies have been performed on the in vitro antioxidant capacity of cereals, but in vivo studies are necessary. We have evaluated and compared the effect of whole grain durum wheat bread and whole grain Kamut khorasan bread on the oxidative status in rats. Two different bread-making processes were used for whole grain Kamut khorasan, sourdough and baker's yeast. After 7 weeks on the experimental diets rats were divided into two subgroups, one receiving an oxidative stress by doxorubicin injection. Our results evidenced both wheat durum and Kamut khorasan as good sources of antioxidants, and a lower oxidative state in rats fed the cereal-based diets. Furthermore, Kamut khorasan bread fed animals had a better response to stress than wheat durum fed, especially when a sourdough bread was supplied. Although further studies are needed, data herein reported suggest whole grains, particularly whole ancient grains, as a safe and convenient way of increasing antioxidant protection.
authors.affiliation: Department of Food Sciences, University of Bologna, Viale Fanin 44, 40127 Bologna, BO, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gianotti
authors.forename: Francesca
authors.initials: F
authors.lastname: Danesi
authors.forename: Vito
authors.initials: V
authors.lastname: Verardo
authors.forename: Diana Isabella
authors.initials: DI
authors.lastname: Serrazanetti
authors.forename: Veronica
authors.initials: V
authors.lastname: Valli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Russo
authors.forename: Ylenia
authors.initials: Y
authors.lastname: Riciputi
authors.forename: Nadia
authors.initials: N
authors.lastname: Tossani
authors.forename: Maria Fiorenza
authors.initials: MF
authors.lastname: Caboni
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Guerzoni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bordoni
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001786:Blood Glucose / Q000378:metabolism; D001939:Bread; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D004317:Doxorubicin; D002523:Edible Grain; D005511:Food Handling; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014908:Triticum
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004043:Dietary Fiber; D004317:Doxorubicin