title: Expression of MGMT and its clinopathological significance in thyroid carcinoma.
abstract: OBJECTIVE
  To study the expression of O(6)-methylguanine-DNA methyltransferase (MGMT) and its clinicopathological significance in thyroid cancer.
  
  
  METHODS
  Immunohistochemistry was used to determine the expression of MGMT in 61 thyroid cancer tissues, 21 thyroid adenomas, 15 Hashimoto's thyroiditis, 8 nodular goiter, and 12 peri-tumor tissues.
  
  
  RESULTS
  There was statistic difference in the expression of MGMT between the normal tissues and thyroid cancers (P<0.05). Expression of MGMT increased from the normal tissue (16.67%, 10/12), nodular goiter (25.00%, 2/8), Hashimoto's thyroiditis (60.00%, 9/15), and thyroid adenoma (52.38%, 11/21)to thyroid cancer (60.66%, 38/61). Expression of MGMT in papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) had significant difference (P<0.05), and the expression level of MGMT decreased with the malignancy of thyroid cancer, such as in PTC (72.22%, 26/36), and FTC (50.00%, 8/16). There was no statistic difference in MGMT expression in sex, age, and nationality (P>0.05).
  
  
  CONCLUSIONS
  High expression of MGMT might be related to the malignancy of thyroid cancer, which may be one of the diagnosis indexes for thyroid cancer. It will be a common clinical index in diagnosing thyroid cancer since there is no difference in MGMT expression among sexes, ages, and nationalities.
authors.affiliation: Department of Biology, College of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Xiamixinuer
authors.initials: X
authors.lastname: Yilike
authors.forename: Gulinaer
authors.initials: G
authors.lastname: Kuerban
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Shuang
authors.initials: S
authors.lastname: Wu
authors.forename: Abulizi
authors.initials: A
authors.lastname: Abudula
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D019853:O(6)-Methylguanine-DNA Methyltransferase