title: [Effect of corticosterone on the delayed rectified potassium currents of cultured rat hippocampal neurons in vitro].
abstract: OBJECTIVE
  The effect of stress hormone corticosterone on hippocampal neurons delayed rectified potassium currents was probed.
  
  
  METHODS
  The potassium currents of rat hippocampal neurons in primary culture were measured with patch clamp whole-cell recording.
  
  
  RESULTS
  It showed that the amplitudes of the potassium currents in hippocampal neurons decreased. However, the threshold potential of potassium currents increased.
  
  
  CONCLUSIONS
  It is speculated that excessive corticosterone may hurt the hippocampal neurons via its effects on the potassium currents of rat hippocampal cells.
authors.affiliation: Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, TianJin 300050, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Liu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D003345:Corticosterone / Q000494:pharmacology*; D051668:Delayed Rectifier Potassium Channels / Q000187:drug effects*; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar
chemical_list: D051668:Delayed Rectifier Potassium Channels; D003345:Corticosterone