title: Effects of polyphenols from seed shells of Japanese horse chestnut (Aesculus turbinata BLUME) on methotrexate-induced intestinal injury in rats.
abstract: The purpose of this study was to evaluate the effects of polyphenols from seed shells of Japanese horse chestnut (JHP) on methotrexate (MTX)-induced intestinal injury in rats. MTX application caused intestinal morphological injury and increase in malondialdehyde (MDA) levels, decrease in levels of glutathione (GSH) and glutathione peroxidase (GSH-Px) activities in small intestine. However, oral administration of JHP ameliorated MTX-induced intestinal injury and inhibited the increase in MDA and the decrease in GSH and GSH-Px activity in small intestine. In conclusion, our results indicated that oral administration of JHP alleviated MTX-induced intestinal injury through its antioxidant properties.
authors.affiliation: Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4–101 MinamiKoyama-cho, Tottori 680–8553, Japan. sugiyama@muses.tottori-u.ac.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sugiyama
authors.forename: Hideto
authors.initials: H
authors.lastname: Kimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ogawa
authors.forename: Kazushige
authors.initials: K
authors.lastname: Yokota
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D031319:Aesculus / Q000737:chemistry*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007410:Intestinal Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000633:toxicity*; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*
chemical_list: D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D008727:Methotrexate