title: [Effect of sex hormones on secretion of lysozyme in alveolar macrophage].
abstract: OBJECTIVE
  To further explore the functions of alveolar macrophage and their modulation mechanisms, the activity of lysozyme in rat alveolar macrophage assessed by electrophoresis was determined. The effects of androsterone and estradiol on lysozyme secretion and their mechanisms were also studied.
  
  
  RESULTS
  The results showed that androsterone and estradiol increased activity of lysozyme significantly (P < 0.01), indomethacin abolished those effects. This suggests that the insufficiency of sex hormones secretion as the retrogression of gonads is involved in the decrease of immunological functions, and the susceptibility to infectious diseases.
  
  
  CONCLUSIONS
  Sex hormones increased activity of lysozyme, and those effects related to prostaglandin.
authors.affiliation: Department of Physiology, Xiang-Ya Medical College, Central South University, Changsha 410078, China.
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Zhang
authors.forename: Cha-Xiang
authors.initials: CX
authors.lastname: Guan
authors.forename: Fu-Wen
authors.initials: FW
authors.lastname: Zhou
mesh_terms: D000738:Androsterone / Q000494:pharmacology*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009113:Muramidase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004958:Estradiol; D000738:Androsterone; D009113:Muramidase; D007213:Indomethacin