title: Neonatal sensory deprivation promotes development of absence seizures in adult rats with genetic predisposition to epilepsy.
abstract: Absence epilepsy has age-related onset. In a WAG/Rij rat genetic model, absence seizures appear after puberty and they are increased with age. It is known that (1) epileptic activity in WAG/Rij rats is initiated at the perioral area in the somatosensory cortex; (2) sensory deprivation, i.e., whisker trimming during the critical period of development, could enhance excitatory activity in the somatosensory cortex. It is hypothesized that the cortex may become more excitable after neonatal vibrissae removal, and this may precipitate absence seizures in adult rats. We found that whisker trimming during the first postnatal weeks caused more rapid development of EEG seizure activity in adult WAG/Rij rats. Epileptic discharges in the trimmed rats were more numerous (vs control), showed longer duration and often appeared in desynchronized and drowsy EEG. The number of absence-like spindle-shaped EEG events (spike-wave spindles) in the whisker-trimmed rats was higher than in control, especially during the intermediate sleep state. An age-dependent increase of intermediate sleep state was found in the trimmed rats, but not in the intact animals. We discuss epigenetic factors that can modulate absence epilepsy in genetically prone subjects.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia. jenia-s@mail.ru
authors.forename: Evgenia
authors.initials: E
authors.lastname: Sitnikova
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D058256:Brain Waves / Q000235:genetics; D003714:Denervation; D004195:Disease Models, Animal; D004832:Epilepsy, Absence / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D051381:Rats; D011922:Rats, Mutant Strains; D012683:Sensory Deprivation / Q000502:physiology*; D013003:Somatosensory Cortex / Q000254:growth & development / Q000503:physiopathology*