title: Cardioprotection through autophagy: ready for clinical trial?
abstract: Interventions that reduce infarct size in animal models have largely failed to improve outcome in patients suffering acute myocardial infarction (MI), or 'heart attack'. Our group recently reported a reduction of infarct size by chloramphenicol treatment in a porcine in vivo model of acute MI, through a mechanism involving the induction of autophagy. Since 2005 several studies have implicated autophagy as a target for cardioprotection.
authors.affiliation: Radical Therapeutix, Inc., Solana Beach, CA, USA. rgottlieb@radicaltx.com
authors.forename: Roberta A
authors.initials: RA
authors.lastname: Gottlieb
authors.forename: Robert M
authors.initials: RM
authors.lastname: Mentzer
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001343:Autophagy; D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002986:Clinical Trials as Topic; D015897:Comorbidity; D003331:Coronary Vessels / Q000473:pathology; D006801:Humans; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D010919:Placebos; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D010919:Placebos; D002701:Chloramphenicol; C026016:chloramphenicol succinate