title: [The effect of chronic intermittent hypoxia on p38MAPK in cerebral tissues of weanling rats].
abstract: OBJECTIVE
  To study the effect of chronic intermittent hypoxia on p38MAPK in partial cerebral tissues of weanling rats.
  
  
  METHODS
  Randomly, fifty male SD rats (3-week-old-4-week-old) were divided into five groups: 2-week-CIH group (2IH), 4-week-CIH group (4IH), 4-week-recovery group (4F), 2-week-control group (2C) and 4-week-control group (4C). Intermittent hypoxia model was induced by an intermittent hypoxia cabin. The expression of p38MAPK mRNA and the phosphorylation levels of p38MAPK (p-p38 protein) in the hippocampus and prefrontal cortex were measured by RT-PCR or Western blot respectively.
  
  
  RESULTS
  No matter in the hippocampus, or in the prefrontal cortex, the expression of p38MAPK mRNA and p-p38 protein in 2IH, 4IH and 4F groups were respectively higher than 2C and 4C groups (P < 0.05, respectively).
  
  
  CONCLUSIONS
  Chronic intermittent hypoxia can activate the p38MAPK in partial cerebral tissues of weanling rats.
authors.affiliation: Department of Child Health Care Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou 325027, China.
authors.forename: Yong-Hai
authors.initials: YH
authors.lastname: Zhou
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Cai
authors.forename: Cun-Xue
authors.initials: CX
authors.lastname: Zhang
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Jia
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Gong
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000201:enzymology*; D000860:Hypoxia / Q000201:enzymology / Q000503:physiopathology*; D008297:Male; D017397:Prefrontal Cortex / Q000201:enzymology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D048051:p38 Mitogen-Activated Protein Kinases