title: Role of a-kinase anchoring proteins (AKAPs) in reproduction.
abstract: Rapid spatio-temporal organized intracellular signaling is a pivotal mechanism for regulation of functions in many cells, in particular in the female and male gametes, in which functional regulation through rapid increases in protein content is not possible since the mechanisms of transcription/translation are somehow frozen due to meiosis block or DNA condensation respectively. A kinase-anchoring proteins (AKAPs) represent a functional conserved family of signal-organizing scaffolding proteins, which due to the specific subcellular distribution and focally compartmentalized cyclic-AMP-dependent protein kinase (PKA) and other enzymes, assuring the coordination of cAMP-responsive events and their integration with other intracellular signals. This review summarizes the actual knowledge on AKAP structure and functions, taking into particular account the role of different AKAPs in regulating reproductive functions such as gametogenesis. Evidence for sperm specific AKAP isoforms and their initiated signaling cascades in mature sperm and the role of this focally activated super-molecular signaling complex in motility are discussed in details with particular emphasis on putative relations between AKAP structural and functional alterations and defects in sperm motility.
authors.affiliation: Department of Clinical Physiopathology, Centre of Research, Endocrinology Unit, Transfer and High Education, DENOthe, University of Florence, Firenze, Italy. m.luconi@dfc.unifi.it
authors.forename: Michaela
authors.initials: M
authors.lastname: Luconi
authors.forename: Giulia
authors.initials: G
authors.lastname: Cantini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Baldi
authors.forename: Gianni
authors.initials: G
authors.lastname: Forti
mesh_terms: D054758:A Kinase Anchor Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000818:Animals; D053627:Asthenozoospermia; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005260:Female; D005306:Fertilization / Q000502:physiology; D006801:Humans; D008297:Male; D009866:Oogenesis / Q000502:physiology; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013081:Sperm Motility; D013091:Spermatogenesis / Q000502:physiology; D013094:Spermatozoa / Q000502:physiology
chemical_list: D054758:A Kinase Anchor Proteins; C119530:AKAP3 protein, human; C485480:AKAP4 protein, human; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases