title: Antibody response against Anopheles albimanus (Diptera: Culicidae) salivary protein as a measure of mosquito bite exposure in Haiti.
abstract: Antibodies against arthropod saliva have shown to be a good marker of bite exposure. Because Anopheles albimanus Wiedemann (Diptera: Culicidae) is the principal malaria vector in Haiti, we evaluated the immune response against salivary gland extract (SGE) of this species in malaria-positive and malaria-negative subjects from this country. The results showed that the level of anti-SGE immunoglobulin (Ig)G antibodies was higher in patients with clinical malaria than those in malaria uninfected people living in the same region. In addition, a significant positive correlation between the level of anti-An. albimanus IgG and IgM antibody levels was observed. These results suggest that antibodies against An. albimanus saliva, especially IgG, are useful markers of mosquito bite exposure in Haiti.
authors.affiliation: Department of Tropical Medicine, SPHTM, Tulane University, New Orleans, LA 70112, USA. blondono@tulane.edu
authors.forename: Berlin L
authors.initials: BL
authors.lastname: Londono-Renteria
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Eisele
authors.forename: Joseph
authors.initials: J
authors.lastname: Keating
authors.forename: Mark A
authors.initials: MA
authors.lastname: James
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Wesson
mesh_terms: D000818:Animals; D000852:Anopheles / Q000276:immunology*; D000906:Antibodies / Q000097:blood*; D006205:Haiti / Q000453:epidemiology; D006801:Humans; D007299:Insect Bites and Stings; D008288:Malaria / Q000097:blood / Q000453:epidemiology; D012471:Salivary Proteins and Peptides / Q000276:immunology*; D013997:Time Factors
chemical_list: D000906:Antibodies; D012471:Salivary Proteins and Peptides