title: State of the art in topical wound-healing products.
abstract: Chronic wounds represent a significant medical burden. Such wounds fail to normally progress through the stages of healing, often complicated by a proinflammatory milieu caused by increased proteinases, hypoxia, and bacterial burden. As a result, several modalities, such as dressings, antimicrobials, growth factors, and human skin substitutes, have been devised in an attempt to correct the chronic wound environment. This review addresses these modalities with a focus on evidence and randomized controlled trials.
authors.affiliation: Miami, Fla. From the University of Miami, Miller School of Medicine, and the Department of Dermatology and Cutaneous Surgery, University of Miami.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Fan
authors.forename: Jennifer
authors.initials: J
authors.lastname: Tang
authors.forename: Julia
authors.initials: J
authors.lastname: Escandon
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kirsner
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001458:Bandages; D002908:Chronic Disease; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D016038:Skin Transplantation; D017768:Skin, Artificial; D023822:Tissue Engineering; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014947:Wounds and Injuries / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000890:Anti-Infective Agents; D036341:Intercellular Signaling Peptides and Proteins