title: [Mechanism of the influence of CCE3 on bone mineral element metabolism in ovariectomized rats].
abstract: OBJECTIVE
  To investigate the influence of CCE3 on bone mineral element metabolism and relative hormone in ovariectomized rats.
  
  
  METHODS
  24 female SD rats were divided randomly into 4 groups (n = 6): (1) Normal control; (2) sham ovariectomy; (3) ovariectomy(OVX); (4) OVX + CCE3.
  
  
  RESULTS
  (1) Ca, Mg, S, Co, Mn, Zn reduced obviously and P increased in the bone of the OVX rats. (2) E2, P, TSH, T4, CT, cortisol, GH reduced obviously and IL-6, FSH, LH increased obviously in serum of the OVX rats. (3) CCE3 corrected the changes of Ca, Mg, S, Co, Mn, Zn and P in bone as well as the changes of E2, P, TSH, T4, CT, cortisol, GH and IL-6, FSH, LH in serum of the OVX rats.
  
  
  CONCLUSIONS
  Changes of relative hormone and IL-6 induced by CCE3 are the important mechanism of the influence of CCE3 on bone mineral element metabolism in ovariectomized rats.
authors.affiliation: Department of Physiology, Guangdong Medical College, Zhanjiang, China.
authors.forename: Zhao-Qiang
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Hao-Yu
authors.initials: HY
authors.lastname: Liu
authors.forename: Xi-Yi
authors.initials: XY
authors.lastname: Liu
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D004964:Estriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D010024:Osteoporosis / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D010052:Ovariectomy; D011800:Quinestrol / Q000031:analogs & derivatives; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015850:Interleukin-6; C010722:nylestriol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004964:Estriol; D011800:Quinestrol