title: Lipid membrane composition influences drug release from dioleoylphosphatidylethanolamine-based liposomes on exposure to ultrasound.
abstract: The effect of membrane composition on calcein release from dioleoylphosphatidylethanolamine (DOPE)-based liposomes on exposure to low doses of 1.13 MHz focused ultrasound (US) was investigated by multivariate analysis, with the goal of designing liposomes for US-mediated drug delivery. Regression analysis revealed a strong correlation between sonosensitivity and the non-bilayer forming lipids DOPE and pegylated distearoylphosphatidylethanolamine (DSPE-PEG 2000), with DOPE having the strongest impact. Unlike most of the previously studied distearoylphosphatidylethanolamine (DSPE)-based liposomes, all the current DOPE-based liposome formulations were found stable in 20% serum in terms of drug retention.
authors.affiliation: Epitarget AS, Oslo, Norway.
authors.forename: Tove J
authors.initials: TJ
authors.lastname: Evjen
authors.forename: Esben A
authors.initials: EA
authors.lastname: Nilssen
authors.forename: Robert A
authors.initials: RA
authors.lastname: Fowler
authors.forename: Sibylla
authors.initials: S
authors.lastname: Røgnvaldsson
authors.forename: Martin
authors.initials: M
authors.lastname: Brandl
authors.forename: Sigrid L
authors.initials: SL
authors.lastname: Fossheim
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D004355:Drug Stability; D005452:Fluoresceins / Q000737:chemistry; D008081:Liposomes; D008956:Models, Chemical; D015999:Multivariate Analysis; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012044:Regression Analysis; D014465:Ultrasonics
chemical_list: C519184:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000); D000970:Antineoplastic Agents; D005452:Fluoresceins; D008081:Liposomes; D010714:Phosphatidylethanolamines; C094877:dioleoyl phosphatidylethanolamine; D011092:Polyethylene Glycols; C007740:fluorexon