title: HCV infection and the incidence of CKD.
abstract: BACKGROUND
  The risk of hepatitis C virus (HCV) infection upon incident chronic kidney disease (CKD) in the presence of traditional risk factors and renal-modifying therapy is not well known.
  
  
  METHODS
  National cohort study.
  
  
  METHODS
  HCV-infected and -uninfected veterans in ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) in 2001-2006.
  
  
  METHODS
  HCV infection.
  
  
  RESULTS
  Incident CKD stages 3-5.
  
  
  RESULTS
  We identified 18,002 patients with HCV infection and 25,137 controls with estimated glomerular filtration rate >60 mL/min/1.73 m(2) at baseline. HCV-infected patients had a lower prevalence of several CKD risk factors, including diabetes (22.9% vs 26.6%), hypertension (52.4% vs 60.8%), and dyslipidemia (39.3% vs 73.9%; P < 0.001). HCV infection was associated with a higher risk of developing CKD stages 3-5 (HR, 1.30; 95% CI, 1.23-1.37). Increasing age, hypertension, and diabetes were associated with significantly higher risks of developing CKD in HCV-infected patients and controls. Decompensated liver disease was a strong predictor of CKD in HCV-infected patients (HR, 3.37; 95% CI, 3.10-3.66) and HCV-uninfected controls (HR, 2.04; 95% CI, 1.84-2.25). In Kaplan-Meier analysis, HCV-infected persons had a shorter time to CKD.
  
  
  CONCLUSIONS
  Lack of proteinuria data; small number of women.
  
  
  CONCLUSIONS
  HCV infection is associated with higher risk and shorter time to CKD despite having a lower prevalence of many CKD risk factors. HCV-infected persons should have targeted monitoring for the development and progression of CKD.
authors.affiliation: University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. butta@dom.pitt.edu
authors.forename: Adeel A
authors.initials: AA
authors.lastname: Butt
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Wang
authors.forename: Linda F
authors.initials: LF
authors.lastname: Fried
mesh_terms: D005260:Female; D005919:Glomerular Filtration Rate; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D014728:Veterans