title: Regulation of BCR signaling.
abstract: B cells and antibodies are important elements of acquired humoral immunity in the fight against various pathogens, and signals through the B cell receptor (BCR) are crucial for the development, activation and differentiation of B cells. Our laboratory has focused on understanding the molecular mechanisms of BCR-mediated signaling cascades that regulate these processes in B cells. In this review, I will briefly present our studies that have clarified the molecular components of signaling cascades, mainly focusing on data using DT40 B cells and their genetic variants.
authors.affiliation: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. kurosaki@rcai.riken.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kurosaki
mesh_terms: D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases / Q000276:immunology / Q000378:metabolism; D051966:Phospholipase C gamma / Q000276:immunology / Q000378:metabolism; D051567:Proto-Oncogene Proteins c-vav / Q000276:immunology / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*
chemical_list: D051567:Proto-Oncogene Proteins c-vav; D011947:Receptors, Antigen, B-Cell; D019869:Phosphatidylinositol 3-Kinases; D051966:Phospholipase C gamma