title: Receptor-based discovery strategies for insecticides and parasiticides: a review.
abstract: Drug discovery is an iterative process with high risks and low chance of success. New genomics technologies allow veterinary medicine and agrochemical companies to validate and functionally screen new receptor-based targets, including neuropeptide G-protein coupled receptors, which were previously not amenable to high throughput screening. However this is just the first step in a long process to translate a mechanistic assay hit into a drug on the market. In addition to effectively eradicating pests on crops and parasites on their host, the molecules must also be safe, cheap to synthesise, formulatable and patentable. This is a costly process in which early attrition of unsuitable molecules is key to any successful program. Although first principle discovery is risky the ultimate benefits are considerable and future genomics resources will help to generate higher quality hits to strengthen the discovery pipeline.
authors.affiliation: Pfizer Animal Health, Pfizer Inc, 7000 Portage Road, Kalamazoo, MI, 49009, USA. debra.j.woods@pfizer.com
authors.forename: Debra
authors.initials: D
authors.lastname: Woods
authors.forename: Cheryl
authors.initials: C
authors.lastname: Butler
authors.forename: Tracey
authors.initials: T
authors.lastname: Williams
authors.forename: Karen
authors.initials: K
authors.lastname: Greenwood
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007306:Insecticides / Q000494:pharmacology*; D007448:Invertebrates / Q000187:drug effects; D011955:Receptors, Drug / Q000187:drug effects / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000502:physiology; D018013:Receptors, Neuropeptide / Q000187:drug effects / Q000502:physiology
chemical_list: D000977:Antiparasitic Agents; D001688:Biological Products; D007306:Insecticides; D011955:Receptors, Drug; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide