title: Partial volume correction incorporating Rb-82 positron range for quantitative myocardial perfusion PET based on systolic-diastolic activity ratios and phantom measurements.
abstract: BACKGROUND
  Quantitative myocardial PET perfusion imaging requires partial volume corrections.
  
  
  METHODS
  Patients underwent ECG-gated, rest-dipyridamole, myocardial perfusion PET using Rb-82 decay corrected in Bq/cc for diastolic, systolic, and combined whole cycle ungated images. Diastolic partial volume correction relative to systole was determined from the systolic/diastolic activity ratio, systolic partial volume correction from phantom dimensions comparable to systolic LV wall thicknesses and whole heart cycle partial volume correction for ungated images from fractional systolic-diastolic duration for systolic and diastolic partial volume corrections.
  
  
  RESULTS
  For 264 PET perfusion images from 159 patients (105 rest-stress image pairs, 54 individual rest or stress images), average resting diastolic partial volume correction relative to systole was 1.14 ± 0.04, independent of heart rate and within ±1.8% of stress images (1.16 ± 0.04). Diastolic partial volume corrections combined with those for phantom dimensions comparable to systolic LV wall thickness gave an average whole heart cycle partial volume correction for ungated images of 1.23 for Rb-82 compared to 1.14 if positron range were negligible as for F-18.
  
  
  CONCLUSIONS
  Quantitative myocardial PET perfusion imaging requires partial volume correction, herein demonstrated clinically from systolic/diastolic absolute activity ratios combined with phantom data accounting for Rb-82 positron range.
authors.affiliation: Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Nils P
authors.initials: NP
authors.lastname: Johnson
authors.forename: Stefano
authors.initials: S
authors.lastname: Sdringola
authors.forename: K Lance
authors.initials: KL
authors.lastname: Gould
mesh_terms: D003971:Diastole; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D055414:Myocardial Perfusion Imaging; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography; D012414:Rubidium Radioisotopes; D013599:Systole
chemical_list: D012414:Rubidium Radioisotopes