title: Deep vein thrombosis in protein S deficiency.
abstract: Protein S is a vitamin K-dependent anticoagulant protein. It functions as a cofactor of activated protein C to inactivate activated factor V (FVa) and activated factor VIII (FVIIIa). Its deficiency is a rare condition and can lead to deep vein thrombosis, pulmonary embolism or stroke. It is often treated with long-term anti-coagulant therapy. Protein S deficiency may be hereditary or acquired; the latter is usually due to hepatic diseases or a vitamin K deficiency. Protein S deficiency manifests as an autosomal dominant trait; manifestations of thrombosis are observed in both heterozygous and homozygous genetic deficiencies of protein S. This case report is of DVT due to Protein S deficiency in a 53 year old male. Venous Doppler was used to diagnose DVT and free Protein S level measured by ELISA. IVC filter was placed on the third day of admission.
authors.affiliation: Norvic International Hospital, Thapathali, Kathmandu, Nepal. abhashjoshi221@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Joshi
authors.forename: J P
authors.initials: JP
authors.lastname: Jaiswal
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D018455:Protein S Deficiency / Q000150:complications*; D018608:Ultrasonography, Doppler; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology*; D014859:Warfarin / Q000008:administration & dosage
chemical_list: D000925:Anticoagulants; D014859:Warfarin