title: Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus (GDM): results from a national survey on prevalence of GDM.
abstract: The possibility of the 2 h oral glucose tolerance test (OGTT) as an alternative to the 3 h OGTT was investigated based on data from a national survey on pregnancy-associated diabetes. Data were retrieved from 4179 pregnant women who had OGTT performed after an abnormal 50 g glucose challenge test (GCT). All of the 4 glucose levels during their OGTT were collected and analyzed. According to American Diabetes Association (ADA) gestational diabetes mellitus (GDM) diagnostic criteria, among the 4179 pregnant women who required OGTT, 3429 (82.1%) were normal and 750 (17.9%) were diagnosed as GDM. If the 3rd h glucose levels were omitted from OGTT, 79 cases of GDM (10.5%) would be overlooked. No trend was shown where women with more risk factors were more likely to be overlooked if the 3rd h test was omitted (χ2 for trend=0.038, P>0.05). No significant differences were found in the rate of cesarean section (CS), preterm births or macrosomia between the 79 cases and those with normal OGTT results and in the gestational weeks when OGTT was performed. It shows that in order to diagnose one woman with GDM, another 52 pregnant women would have an innocent 3rd h glucose test. Omission of the 3rd h glucose test in OGTT might be reasonable due to its convenience, better compliance and a small number of possibly miss-diagnosed cases, and their pregnancy outcomes have no significant difference from those of normal pregnant women.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, 100034, China.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Gao
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Wei
authors.forename: Hui-Xia
authors.initials: HX
authors.lastname: Yang
authors.forename: Xian-Ming
authors.initials: XM
authors.lastname: Xu
authors.forename: Ling
authors.initials: L
authors.lastname: Fan
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: San-Cun
authors.initials: SC
authors.lastname: Zhao
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Hu
authors.forename: Zi
authors.initials: Z
authors.lastname: Yang
authors.forename: Yun-Ping
authors.initials: YP
authors.lastname: Zhang
authors.forename: Xing-Hui
authors.initials: XH
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Gou
authors.forename: Mei
authors.initials: M
authors.lastname: Xiao
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Wu
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002681:China / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000453:epidemiology; D005188:False Negative Reactions; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors
chemical_list: D001786:Blood Glucose