title: Physicochemical characterization of nanotemplate engineered solid lipid nanoparticles.
abstract: As the physicochemical characteristics of solid lipid nanoparticles (SLNs) play a critical role in their success, it is important to understand how the materials and process used in their preparation affect these properties. In this study, two stearyl alcohol-based formulations were prepared using nanotemplate engineering technology and characterized. Both formulations were of a small particle size (<100 nm), ellipsoidal shape, and low polydispersity. (1)H NMR spectroscopy confirmed that the SLNs have the expected solid core structure and PEGylated surface. Analysis of the bulk materials indicated that a number of complex interactions are present among the SLN components, including a eutectic between stearyl alcohol and Brij 78. The decreased crystallinity resulting from these interactions may allow for enhanced drug loading. Physiological stability was identified and confirmed as a potential problem due to the low melting point of the eutectic. However, it is expected that with appropriate formulation modifications nanotemplate engineered SLNs will possess the properties necessary for a successful drug delivery system.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, Lexington, Kentucky 40536-0596, United States.
authors.forename: Melissa D
authors.initials: MD
authors.lastname: Howard
authors.forename: Xiuling
authors.initials: X
authors.lastname: Lu
authors.forename: John J
authors.initials: JJ
authors.lastname: Rinehart
authors.forename: Michael
authors.initials: M
authors.lastname: Jay
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Dziubla
mesh_terms: D055598:Chemical Phenomena; D004655:Emulsions; D008027:Light; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D012542:Scattering, Radiation; D014961:X-Ray Diffraction
chemical_list: D004655:Emulsions; D008055:Lipids