title: An atom-economical access to β-heteroarylated ketones from propargylic alcohols via tandem ruthenium/indium catalysis.
abstract: The direct and chemoselective synthesis of β-heteroarylated ketones from secondary propargyl alcohols through tandem Ru/In catalysis is reported. Both electron-rich and neutral heteroarenes, such as furans and indoles, efficiently undergo the redox isomerization/conjugate addition (RICA) sequence to provide the corresponding adducts in yields of up to 97%.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305, USA. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Alexander
authors.initials: A
authors.lastname: Breder
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007204:Indium / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D020005:Propanols / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D007659:Ketones; D020005:Propanols; D007204:Indium; D012428:Ruthenium; C028255:propargyl alcohol