title: Roles of old players in the suppression of a new player: networks for the transcriptional control of angiogenesis.
abstract: During the formation of blood vessels, Id1, a member of the helix-loop-helix (HLH) family, and TAL1/SCL, a basic HLH (bHLH) transcription factor, play important roles in the activation of endothelial cells. Recent reports revealed that E2-2, another bHLH transcription factor, inhibits angiogenesis in vitro and in vivo by suppressing the expression of vascular endothelial growth factor receptor 2 (VEGFR2). Id1 and TAL1/SCL dimerize with E2-2 and relieve the E2-2-mediated down-regulation of VEGFR2 expression, leading to the activation of endothelial cells. These findings reveal a novel interplay between HLH transcription factors that regulate angiogenesis.
authors.affiliation: Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. t-watabe@umin.ac.jp
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Watabe
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism; D019281:Dimerization; D005786:Gene Expression Regulation; D018257:Helix-Loop-Helix Motifs; D051798:Inhibitor of Differentiation Protein 1 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D018919:Neovascularization, Physiologic; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D019485:Bone Morphogenetic Proteins; D051798:Inhibitor of Differentiation Protein 1; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D058118:Transcription Factor 7-Like 2 Protein; D040301:Vascular Endothelial Growth Factor Receptor-2; C544894:TCF7L2 protein, human; C067143:TAL1 protein, human