title: [Experimental study on the effect of ginkgo bioba extract on the expression of heme oxygenase-1 in bronchial asthma].
abstract: OBJECTIVE
  To explore the effect of the ginkgo bioba extract on the expression of heme oxygenase-1 (HO-1) in bronchial asthma.
  
  
  METHODS
  30 guinea pigs were randomly divided into 3 groups (n = 10): (1) Normal control group; (2) Asthmatic group; (3) Therapeutic group. Blood carbon monoxide Hb (COHb) percent value, Airway resistance and eosinophilic inflammation of airway wall were observed, the expression of HO-1 in lung tissue were observed by immunohistochemical staining.
  
  
  RESULTS
  The expression of HO-1 was mainly located in airway epithelium in these 3 groups, the optical densities were 0.170 +/- 0.020, 0.707 +/- 0.058, 0.397 +/- 0.034, respectively. The asthmatic group showed higher optical densities than that of the normal control group (P < 0.01), and the therapeutic group showed lower optical density than asthmatic group (P < 0.01).
  
  
  CONCLUSIONS
  The expression of HO-1 is inhibited significantly by the treatment of the ginkgo bioba extract, which may be one of the mechanism for treating asthma by ginkgo bioba extract.
authors.affiliation: Department of Respiratory Medicine, Hospital affiliated Guilin Medical College, Guilin 541001, China
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Zeng
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zeng
authors.forename: Bi-Wen
authors.initials: BW
authors.lastname: Mo
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D020441:Ginkgo biloba; D006168:Guinea Pigs; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D051547:Heme Oxygenase-1