title: [Effect of ligustrazine and L-arginine on function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits].
abstract: OBJECTIVE
  To study the effect of ligustrazine (LGT) and L-arginine(L-Arg)on function of mitochondria in myocardium after myocardial ischemia/reperfusion injury (MI/RI).
  
  
  METHODS
  50 rabbits were randomly divided into five groups (n=10): Control group(A), MI/R group(B), MI/R + LGT group (C), MI/R+ L-Arg group (D), MI/R+ LGT + L-Arg group (E). The mitochondrial respiratory function, Ca2+ concentration ([Ca2+]m), malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were deter mined. Meanwhile, the contents of ATP and EC in the myocardial tissue were measured, respectively.
  
  
  RESULTS
  It was found that mitochondrial respiratory control rate (RCR), state 3 (ST3), SOD in C, D, E group were higher than those of B group, state 4 (ST4), [Ca2+]m, MDA were lower than those of B group, ATP and EC levels of myocardial tissue were higher than those in B group; and there were not significant differences between E and A group of above.
  
  
  CONCLUSIONS
  LGT and IL-Arg can improve function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits by decreasing oxygen free radical level and Ca" overload in the mitochondria.
authors.affiliation: Department of Pathophysiology, Wenzhou Medical College, China. wzwwt@tom.com
authors.forename: Wan-tie
authors.initials: WT
authors.lastname: Wang
authors.forename: Mao-lin
authors.initials: ML
authors.lastname: Hao
authors.forename: Fang-yan
authors.initials: FY
authors.lastname: Wang
authors.forename: Shi-rong
authors.initials: SR
authors.lastname: Ni
authors.forename: Zhang-juan
authors.initials: ZJ
authors.lastname: Song
authors.forename: Ke-jian
authors.initials: KJ
authors.lastname: Xie
authors.forename: Zhou-xi
authors.initials: ZX
authors.lastname: Fang
mesh_terms: D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D008315:Malondialdehyde / Q000032:analysis; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology; D011719:Pyrazines / Q000494:pharmacology*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D011719:Pyrazines; D008315:Malondialdehyde; D001120:Arginine; D013482:Superoxide Dismutase; D002118:Calcium; C017953:tetramethylpyrazine