title: Adipose-derived stem cells for wound healing applications.
abstract: Nonhealing wounds remain a significant challenge for plastic surgeons. More than 600,000 people suffer from venous ulcers and 1.5 to 3 million people are being treated for pressure sores every year in the United States. The use of tissue engineering techniques such as stem-cell therapy and gene therapy to improve wound healing is a promising strategy. Adipose tissue represents a source of cells that may be able to enhance wound healing. Adipose-derived stem cells (ASCs) are adult stem cells that are easily harvested and of great interest for plastic surgeons. Specifically, ASCs secrete angiogenic growth factors that can induce tissue regeneration. This review describes innovative research strategies using ASCs therapies for treatment of chronic, nonhealing wounds.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Cherubino
authors.forename: J Peter
authors.initials: JP
authors.lastname: Rubin
authors.forename: Natasa
authors.initials: N
authors.lastname: Miljkovic
authors.forename: Arta
authors.initials: A
authors.lastname: Kelmendi-Doko
authors.forename: Kacey G
authors.initials: KG
authors.lastname: Marra
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002908:Chronic Disease; D006801:Humans; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology; D014945:Wound Healing / Q000502:physiology; D014947:Wounds and Injuries / Q000601:surgery*