title: Kidney transplant from the same donor without maintenance immunosuppression after previous hematopoietic stem cell transplant.
abstract: In January 2005, an 18-year-old male patient with acute myeloid leukemia (AML) received a haploidentical hematopoietic stem cell transplantation (HSCT) from his father. He developed hemolytic uremic syndrome and end-stage renal disease (ESRD) requiring hemodialysis on day 357 after HSCT. On day 1020 after HSCT, a living kidney donation from the stem cell donor was carried out. The creatinine before kidney transplantation (KT) was ≈450 μmol/L, 268 μmol/L on day 2 after KT, 88 μM on day 38 and 89 μmol/L on day 960 (day 1980 after HSCT). Immunosuppression was gradually discontinued: cortisone on day 28, tacrolimus on day 32 and MMF on day 100 after KT (day 1120 after HSCT). As of June 2010, 66 months after HSCT and 32 months after KT, the patient has had neither rejection episodes nor clinical manifestations of transplantation-related complications. The patient reached 100% hematopoietic donor chimerism prekidney transplant and retained this state postkidney transplant. This unique case is the first report of a successful kidney transplant without immunosuppression after HSCT from the same haploidentical donor.
authors.affiliation: Department of Surgery, Karl Olga Hospital Stuttgart, Stuttgart, Germany. josef.fangmann@karl-olga-krankenhaus.de
authors.forename: J
authors.initials: J
authors.lastname: Fangmann
authors.forename: H
authors.initials: H
authors.lastname: Kathrin Al-Ali
authors.forename: U
authors.initials: U
authors.lastname: Sack
authors.forename: M
authors.initials: M
authors.lastname: Kamprad
authors.forename: H M
authors.initials: HM
authors.lastname: Tautenhahn
authors.forename: S
authors.initials: S
authors.lastname: Faber
authors.forename: J
authors.initials: J
authors.lastname: Hauss
authors.forename: D
authors.initials: D
authors.lastname: Niederwieser
authors.forename: T
authors.initials: T
authors.lastname: Lindner
authors.forename: A
authors.initials: A
authors.lastname: Bachmann
mesh_terms: D000293:Adolescent; D000328:Adult; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000601:surgery*; D016030:Kidney Transplantation; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D019520:Living Donors; D008297:Male; D018183:Transplantation Chimera