title: Clinical microbiology of neonatal candidiasis in Hungary.
abstract: The occurrence of Candida spp. was investigated during a three-year period in two neonatal intensive care units, Budapest, Hungary. The species distribution among the 41 analysed cases was the following: C. albicans (30/41, 73%), C. parapsilosis (10/41, 24%) and C. glabrata (1/41, 3%). All of the isolates were susceptible to the tested drugs. There was a significant difference in the birth weight, the gestational age <30 weeks and the occurrence of caesarean section between the C. albicans and the C. parapsilosis groups of the cases. Respiratory tract colonization was the same (76-77%) in the extremely low birth weight (ELBW) and the very low birth weight (VLBW) groups. Comparing the ELBW, VLBW, and >1500 g birth weight groups, significant difference was found in the parenteral nutrition, the gestation weeks <36 or <30, the polymicrobial infection and the transfusion. The ratio of C. albicans, C. parapsilosis and C. glabrata was 9:7:1 in ELBW group; 6:3:0 in VLBW group and 15:1:0 in >1500 g group. The mortality rate for C. parapsilosis was higher than for C. albicans.
authors.affiliation: Institute of Laboratory Medicine, Semmelweis University, Budapest, Hungary. krikat@net.sote.hu
authors.forename: Katalin
authors.initials: K
authors.lastname: Kristóf
authors.forename: L
authors.initials: L
authors.lastname: Janik
authors.forename: Kinga
authors.initials: K
authors.lastname: Komka
authors.forename: Agnes
authors.initials: A
authors.lastname: Harmath
authors.forename: Júlia
authors.initials: J
authors.lastname: Hajdú
authors.forename: A
authors.initials: A
authors.lastname: Nobilis
authors.forename: F
authors.initials: F
authors.lastname: Rozgonyi
authors.forename: K
authors.initials: K
authors.lastname: Nagy
authors.forename: J
authors.initials: J
authors.lastname: Rigó
authors.forename: Dóra
authors.initials: D
authors.lastname: Szabó
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D002176:Candida albicans / Q000302:isolation & purification; D041221:Candida glabrata / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality; D002585:Cesarean Section; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D005865:Gestational Age; D006801:Humans; D006814:Hungary; D052577:Infant, Extremely Low Birth Weight; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D007363:Intensive Care Units, Neonatal; D008297:Male; D010288:Parenteral Nutrition
chemical_list: D000666:Amphotericin B; D015725:Fluconazole