title: Predicting the prognosis of oral squamous cell carcinoma after first recurrence.
abstract: OBJECTIVE
  to describe the clinicopathologic features of oral squamous cell carcinoma in patients who develop locoregional recurrence of disease, to identify factors that predict prognosis in the subset of patients treated with salvage surgery, and to determine the adjusted effect of time to recurrence.
  
  
  METHODS
  cohort study.
  
  
  METHODS
  a head and neck cancer institute in Sydney, New South Wales, Australia.
  
  
  METHODS
  a total of 77 patients who underwent salvage surgery for oral squamous cell carcinoma that had been treated initially by surgery, radiotherapy, or surgery with postoperative radiotherapy.
  
  
  METHODS
  univariable and multivariable analysis of clinical and pathologic risk factors.
  
  
  RESULTS
  median time to recurrence from initial treatment was 7.5 months (range, 0.9-143.9 mo), with 86% of recurrences occurring within the first 24 months. Surgical salvage was attempted in 77 patients who had experienced recurrence at the primary site (n = 39), ipsilateral neck (n = 27), and contralateral neck (n = 11). Time to recurrence, initial treatment modality, and site of failure were independent prognostic variables.
  
  
  CONCLUSIONS
  the relationship of these prognostic variables displays a dynamic interaction. Initial combined-modality treatment and shorter time to recurrence were associated with worse outcome, while the effect of site of recurrence (local vs regional) was dependent on an interaction with the time to recurrence. The result of this interaction was that local recurrence was worse for those who experienced it early (eg, <6 mo after the initial treatment) and nodal recurrence was worse for those who experienced it late (eg, ≥ 6 mo after the intial treatment).
authors.affiliation: Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Kernohan
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Clark
authors.forename: Kan
authors.initials: K
authors.lastname: Gao
authors.forename: Ardalan
authors.initials: A
authors.lastname: Ebrahimi
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Milross
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D009517:New South Wales / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome