title: [Peculiarities of the treatment of patients presenting with chronic suppurative otitis media associated with Gram-negative microorganisms].
abstract: The objective of the present study was to determine the absolute and relative numbers of T-lymphocytes, B-lymphocytes, T-suppressors, T-helpers, phagocytes, immunoglobulins A, M, and G in blood sera of patients presenting with chronic suppurative otitis media who had undergone sanation surgery. The study included tests for the evaluation of immunological efficiency of combined treatment with imunofan and myelopid in 89 patients divided into two groups. Pretreatment immunological status of all patients was characterized by reduced B-lymphocyte, T-helper, and phagocyte counts coupled to the elevated levels of IgM and T-suppressors. Patients of group 1 received conventional antibacterial therapy, those in group 2 were treated with a combination of imunofan and myelopid. Conventional therapy failed to correct immune deficiency. Additional treatment with a combination of imunofan and myelopid following sanation surgery proved to be much more efficacious. This observation was confirmed by the results of clinical, cytological, and immunological studies.
authors.forename: S D
authors.initials: SD
authors.lastname: Poliakova
authors.forename: E A
authors.initials: EA
authors.lastname: Popova
authors.forename: Ia P
authors.initials: IaP
authors.lastname: Rodinko
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D004359:Drug Therapy, Combination; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007155:Immunologic Factors / Q000627:therapeutic use; D007167:Immunotherapy; D018655:Lymphocyte Count; D009842:Oligopeptides / Q000627:therapeutic use; D010035:Otitis Media, Suppurative / Q000276:immunology* / Q000601:surgery / Q000628:therapy*; D011184:Postoperative Period; D011552:Pseudomonas Infections / Q000276:immunology* / Q000601:surgery / Q000628:therapy*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007155:Immunologic Factors; D009842:Oligopeptides; C080035:thymohexin; C048617:myelopeptides