title: Genetic covariation underlying reading, language and related measures in a sample selected for specific language impairment.
abstract: Specific language impairment is a developmental language disorder characterized by failure to develop language normally in the absence of a specific cause. Previous twin studies have documented the heritability of reading and language measures as well as the genetic correlation between those measures. This paper presents results from an alternative to the classical twin designs by estimating heritability from extended pedigrees. These pedigrees were previously studied as part of series of molecular genetic studies of specific language impairment where the strongest genetic findings were with reading phenotypes rather than language despite selecting pedigrees based on language impairments. To explore the relationship between reading and language in these pedigrees, variance components estimates of heritability of reading and language measures were conducted showing general agreement with the twin literature, as were genetics correlations between reading and language. Phonological short-term memory, phonological awareness and auditory processing were evaluated as candidate mediators of the reading-language genetic correlations. Only phonological awareness showed significant genetic correlations with all reading measures and several language measures while phonological short-term memory and auditory processing did not.
authors.affiliation: Department of Human Development and Family Science, The Ohio State University, Columbus, OH 43205, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Logan
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Petrill
authors.forename: Judy
authors.initials: J
authors.lastname: Flax
authors.forename: Laura M
authors.initials: LM
authors.lastname: Justice
authors.forename: Liping
authors.initials: L
authors.lastname: Hou
authors.forename: Anne S
authors.initials: AS
authors.lastname: Bassett
authors.forename: Paula
authors.initials: P
authors.lastname: Tallal
authors.forename: Linda M
authors.initials: LM
authors.lastname: Brzustowicz
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Bartlett
mesh_terms: D002170:Canada; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D006801:Humans; D007802:Language; D007806:Language Disorders / Q000235:genetics*; D008297:Male; D008569:Memory Disorders / Q000235:genetics; D008570:Memory, Short-Term; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D011932:Reading; D014481:United States