title: [Effect of hypoxic hypercapnia on expression of COX-2 mRNA in pulmonary arterioles].
abstract: OBJECTIVE
  To study the effect of chronic hypoxic hypercapnia on expression of COX-2 mRNA in pulmonary arterioles.
  
  
  METHODS
  SD rats were randomly divided into two groups: control group and hypoxic hypercapnic group. COX-2 mRNA was observed in pulmonary arterioles by the technique of in situ hybridization.
  
  
  RESULTS
  mPAP, weight ratio of right ventricle (RV) to left ventricle plus septum (LV + S) and COX-2 mRNA in pulmonary arterioles were much higher in rats of hypoxic hypercapnic group than those of control group. Light microscopy showed that vessel smooth muscle cell hypertrophy and vessel cavity straightness were found in hypoxic hypercapnic group.
  
  
  CONCLUSIONS
  Changes of expressions of COX-2 mRNA may regulate hypoxic hypercapnic pulmonary hypertension.
authors.affiliation: Department of Respirology, First Hospital, Wenzhou Medical College, Wenzhou 325003, China.
authors.forename: Hai-Huan
authors.initials: HH
authors.lastname: Zeng
authors.forename: Liang-Xing
authors.initials: LX
authors.lastname: Wang
authors.forename: Shao-Xian
authors.initials: SX
authors.lastname: Chen
authors.forename: Ming-Shan
authors.initials: MS
authors.lastname: Wang
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Fan
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D006935:Hypercapnia / Q000378:metabolism* / Q000503:physiopathology; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D011651:Pulmonary Artery / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat