title: Simultaneous assessment of pulsating and total blood in inflammatory skin lesions using functional diffuse reflectance spectroscopy in the visible range.
abstract: We present a simple and cost-effective optical technique for the simultaneous assessment of pulsating and total blood noninvasively in an inflammatory skin lesion. Acquisitions of diffuse reflectance spectra in the visible range at 6 Hz are used to trace the oscillating components of reflectance. Measurements on erythematous lesions from a UV insult show slow changing signal at about 0.1 Hz and heart-driven regular oscillations at about 1 Hz simultaneously. The results demonstrate the potential of the technique in monitoring both pulsating and steady components of the blood in inflammatory lesions of the skin.
authors.affiliation: Johnson and Johnson Consumer Products Company, Skillman, NJ 08558, USA. iseo@its.jnj.com
authors.forename: InSeok
authors.initials: I
authors.lastname: Seo
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Bargo
authors.forename: Nikiforos
authors.initials: N
authors.lastname: Kollias
mesh_terms: D001783:Blood Flow Velocity; D001810:Blood Volume; D001811:Blood Volume Determination / Q000379:methods*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004890:Erythema / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D011673:Pulsatile Flow; D012867:Skin / Q000098:blood supply / Q000503:physiopathology*; D013057:Spectrum Analysis / Q000379:methods*