title: Axelrod, the pineal and the melatonin hypothesis: lessons of 50 years to shape chronodisruption research.
abstract: With key work in the 1950s and 1960s, the 1970 Nobel laureate Julius Axelrod made major contributions to the development of pineal science. Looking back at some of his accomplishments in and for the field, we feel that lessons can be derived for future work regarding impairments of the pineal gland's and melatonin's many functions for promoting health and preventing disease in man.
authors.affiliation: Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University of Cologne, Lindenthal, Germany. tim.erren@uni-koeln.de
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Erren
authors.forename: Russel J
authors.initials: RJ
authors.lastname: Reiter
mesh_terms: D035843:Biomedical Research / Q000266:history* / Q000639:trends; D057906:Circadian Clocks / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008027:Light; D008550:Melatonin / Q000096:biosynthesis / Q000266:history*; D009490:Neurosecretory Systems / Q000502:physiology; D009613:Nobel Prize; D010870:Pineal Gland / Q000502:physiology; D014481:United States
chemical_list: D008550:Melatonin