title: Chronic thrombotic scarring in patients with acute deep venous thrombosis of the lower limbs.
abstract: Some patients with acute deep venous thrombosis of the lower limbs may present risk factors for recurrent disease.
  
  
  OBJECTIVE
  To analyze the most important conditions related to recurrent deep venous thrombosis of the lower limbs, other than thrombophilias.
  
  
  METHODS
  We examined 88 consecutive patients (47 males-53.41%, average age 64.9 +/-13.9 years) admitted to a Medical Clinic in 2007. Duplex ultrasonography was performed to assess acute deep venous thrombosis and post-thrombotic syndrome. Anamnesis and physical examination were used to detect risk factors for recurrent disease. The 28 subjects with acute deep venous thrombosis and post-thrombotic syndrome were included in group A (31.82%). Group B comprised 60 patients (68.18%) with acute deep venous thrombosis without post-thrombotic syndrome.
  
  
  RESULTS
  Risk factors for recurrent disease in groups A and B were the following: personal history of deep venous thrombosis of the lower limbs (17 subjects versus 7, p<0.0001), varicose veins (14 vs 24, p=0.51), obesity (13 vs 18, p=0.21), malignancy (6 vs 8, p=0.25), chronic obstructive lung disease (5 vs 6, p=0.24), prolonged immobilization (1 vs 7, p=0.21), major surgery (1 vs 1, p=0.54), stroke (0 vs 3, p=0.62), family history of deep venous thrombosis, immobilizing plaster cast, and congestive heart failure (0 vs 1, p=0.54). Location of thrombi in patients in groups A and B was as follows: 18 patients in group A vs 25 subjects in group B on the left side and 13 patients in group A vs 20 patients in group B on the right side (p=0.02).
  
  
  CONCLUSIONS
  Post-thrombotic syndrome correlated with personal history of deep venous thrombosis and previous deep venous thrombosis located in the left lower limb.
authors.affiliation: 5th Medical Clinic, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, str. Tabacarilor 11, 400139 Cluj-Napoca, Romania. crisan.sorin@gmail.com
authors.forename: Sorin
authors.initials: S
authors.lastname: Crişan
authors.forename: Stefan
authors.initials: S
authors.lastname: Vesa
authors.forename: Cătălin
authors.initials: C
authors.lastname: Pestrea
authors.forename: Delia
authors.initials: D
authors.lastname: Herghea
authors.forename: Daniela
authors.initials: D
authors.lastname: Vornicescu
authors.forename: Monica
authors.initials: M
authors.lastname: Chirilă
authors.forename: Iulia Maria
authors.initials: IM
authors.lastname: Crişan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002908:Chronic Disease; D002921:Cicatrix / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D018616:Ultrasonography, Doppler, Duplex; D020246:Venous Thrombosis / Q000000981:diagnostic imaging*