title: [Association between polymorphism of rs3212855 and rs5515 of KLK1 gene with cerebral hemorrhage in Changsha Han population].
abstract: OBJECTIVE
  To explore the association between single nucleotide polymorphism (SNPs) of KLK1 gene and cerebral hemorrhage in Changsha Han population.
  
  
  METHODS
  We enrolled 273 patients with cerebral hemorrhage and 140 normal people. The SNPs (including rs3212855 and rs5515) of KLK1 gene were analyzed by Snapshot method and direct sequencing.
  
  
  RESULTS
  We found rs5515 was not a polymorphic site in Changsha Han population. Genotype and allele frequency in rs3212855 were not different between patients with cerebral hemorrhage and the controls (P>0.05). The blood pressure level was not different between the genotype subgroups.
  
  
  CONCLUSIONS
  Neither rs5515 nor rs3212855 is associated with cerebral hemorrhage.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhongyang
authors.initials: Z
authors.lastname: Hu
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Shuyu
authors.initials: S
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Baoqiong
authors.initials: B
authors.lastname: Liu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: DU
authors.forename: Jian
authors.initials: J
authors.lastname: Xia
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongwei
authors.initials: H
authors.lastname: Xu
authors.forename: Qidong
authors.initials: Q
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D007610:Kallikreins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D007610:Kallikreins; C120801:kallikrein 4