title: [Effect of bombesin on IFN-induced fever and AVP content in brain of rats].
abstract: OBJECTIVE
  To determine whether bombesin prevents IFN-alpha-induced fever and it's possible mechanism.
  
  
  METHODS
  Effects of BN on changes in body temperature and arginine vasopressin(AVP) content in the ventral septal area(VSA) and hypothalamus were measured in the rats following intracerebroventricular (ICV) injection of IFN-alpha.
  
  
  RESULTS
  (1) IFN-alpha produced a dose-dependent rise in colonic temperature simultaneously with increase in AVP content in the VSA in the rats. (2) BN produced a dose-dependent hypothermia and significantly elevated AVP content in the VSA in rats. (3) BN injected intracerebroventricularly at 30 min after IFN-alpha prevented the increase in colonic temperature which recovered to the control level as well as AVP content in the VSA in rats at 150 min.
  
  
  CONCLUSIONS
  AVP in the VSA may play a role in IFN-alpha-induced fever. AVP in the VSA may play a partial role in the BN antipyretic action and hypothermic action.
authors.affiliation: Department of Physiology, Chinese Medical University, Liaoning Shenyang 110001, China.
authors.forename: Xiao-yang
authors.initials: XY
authors.lastname: Zhou
authors.forename: Shu-feng
authors.initials: SF
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001833:Body Temperature Regulation / Q000187:drug effects; D001839:Bombesin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D016898:Interferon-alpha / Q000009:adverse effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016898:Interferon-alpha; D001127:Arginine Vasopressin; D001839:Bombesin