title: No association of the YWHAE gene with schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population.
abstract: YWHAE is a gene encoding 14-3-3epsilon, which is highly conserved across species, from bacteria to humans, and binds to phosphoserine/phosphothreonine motifs in a sequence-specific manner. YWHAE has been reported to be associated with schizophrenia in a study based on the Japanese population. Here, we conducted a genetic association analysis between common SNPs in the YWHAE gene and psychiatric diseases including schizophrenia, major depressive disorder and bipolar disorder in Han Chinese samples (1140 schizophrenia cases, 1140 major depressive disorder cases, 1140 bipolar disorder cases and 1140 normal controls). We studied 11 SNPs, seven of which had previously been reported as significant, in YWHAE. No association was found with schizophrenia, major depressive disorder or bipolar disorder. Considering the size of our sample sets (power > 90%), our results suggest that the YWHAE does not play a major role in schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population.
authors.affiliation: Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, The Central White Building, 1954 Huashan Road, Shanghai, 200030, People's Republic of China. liujie007007@hotmail.com
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Guoquan
authors.initials: G
authors.lastname: Zhou
authors.forename: Weidong
authors.initials: W
authors.lastname: Ji
authors.forename: Junyan
authors.initials: J
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Ti
authors.initials: T
authors.lastname: Wang
authors.forename: You
authors.initials: Y
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zeng
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Hu
authors.forename: Linqing
authors.initials: L
authors.lastname: Zheng
authors.forename: Jue
authors.initials: J
authors.lastname: Ji
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wei
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
mesh_terms: D048948:14-3-3 Proteins / Q000737:chemistry / Q000235:genetics*; D000328:Adult; D001714:Bipolar Disorder / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003865:Major Depressive Disorder / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: D048948:14-3-3 Proteins; C482983:YWHAE protein, human