title: Angioscopic study of silent plaque disruption in nonischemic related coronary artery in patients with stable ischemic heart disease.
abstract: Plaque disruption, which may be associated with some coronary risk factors, plays a key role in the development of acute coronary syndromes and progression of atherosclerosis. However, the clinical profile of asymptomatic plaque disruption in stable ischemic heart disease has not been well evaluated. The aim of the present study was to investigate the frequency and determinants of silent plaque disruption (SPD) in patients with stable ischemic heart disease using coronary angioscopy. Forty-one patients with stable angina or old myocardial infarction (OMI) without any complaints within 3 months were included in the present study. Angioscopy was successfully performed through 49 nonischemic related coronary arteries. The presence of SPD and coronary risk factors were recorded. Silent plaque disruption was found in 12 patients with stable ischemic heart disease (12/41, 29.3%), and the frequency of SPD in nonischemic related coronary arteries was 26.5% (13/49). A significantly higher frequency of SPD was noted in yellow plaques than in white plaques (35.3% versus 6.7%, P = 0.043). Overall, the independent clinical risk factors of SPD in nonischemic related coronary arteries were diabetes mellitus (P = 0.018; OR, 18.8209; 95% CI, 1.6525 to 214.3523) and hypertension (P = 0.0313; OR, 6.6485; 95% CI, 1.1850 to 37.3019). These results suggest silent plaque disruption was commonly observed in nonischemic related coronary arteries in patients with stable ischemic heart disease and its determinants were diabetes mellitus and hypertension.
authors.affiliation: First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: Zuoyan
authors.initials: Z
authors.lastname: Wang
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Inami
authors.forename: Sonoko
authors.initials: S
authors.lastname: Kirinoki
authors.forename: Hideo
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Gen
authors.initials: G
authors.lastname: Takagi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Aoki
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takano
authors.forename: Kuniya
authors.initials: K
authors.lastname: Asai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yasutake
authors.forename: Masamichi
authors.initials: M
authors.lastname: Takano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohba
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Mizuno
mesh_terms: D000368:Aged; D017546:Angioscopy; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D058226:Plaque, Atherosclerotic / Q000175:diagnosis*; D012307:Risk Factors