title: Biocompatible dispersions of carbon nanotubes: a potential tool for intracellular transport of anticancer drugs.
abstract: The use of the biocompatible amphiphilic diblock copolymer poly(ethylene glycol-b-propylene sulfide) (PEG44PPS20) allows a tuned loading of doxorubicin onto the surface of non-functionalized multi-walled carbon nanotubes and an efficient cell internalization. The obtained multi-walled carbon nanotube-based systems show enhanced cytotoxic activity with respect to non-vehicled doxorubicin.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università G. d'Annunzio, Via dei Vestini, I-66013, Chieti, Italy.
authors.forename: Antonello
authors.initials: A
authors.lastname: Di Crescenzo
authors.forename: Diana
authors.initials: D
authors.lastname: Velluto
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Hubbell
authors.forename: Antonella
authors.initials: A
authors.lastname: Fontana
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D003102:Colloids / Q000138:chemical synthesis; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D005240:Feasibility Studies; D006801:Humans; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003102:Colloids; D053769:Nanocapsules; D004317:Doxorubicin