title: Ileal bladder augmentation and vitamin B12: levels decrease with time after surgery.
abstract: OBJECTIVE
  We investigated vitamin B12 deficiency following ileocystoplasty in children.
  
  
  METHODS
  Patients who underwent ileocystoplasty between December 1993 and September 2006 were included and B12 levels were retrospectively analysed. Patients with a serum B12 of less than 150 pg/ml were considered deficient. The distance of the ileal segment from the ileocaecal valve was recorded.
  
  
  RESULTS
  There were 105 patients in the series; 61 were male. Mean age at surgery was 7.7 years (SD = 3.9). The mean interval from surgery to most recent B12 level was 50 months (SD = 30). None of the patients were on B12 supplementation. Two patients were B12 deficient, both more than 7 years after surgery; 44% of patients with levels available 7 years after surgery had a B12 below 300 pg/ml. There was a significant negative correlation between B12 level and length of follow up (Spearman's rank, P < 0.01). Twenty patients with an ileal segment sparing 60 cm from the ileocaecal valve had a higher mean B12 (524 vs 419, SEM 60 vs 28). This was not statistically significant.
  
  
  CONCLUSIONS
  We demonstrate a reduction in serum B12 level with time following ileocystoplasty. These patients should have their B12 levels measured in the long term.
authors.affiliation: Department of Urology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Blackburn
authors.forename: S
authors.initials: S
authors.lastname: Parkar
authors.forename: M
authors.initials: M
authors.lastname: Prime
authors.forename: L
authors.initials: L
authors.lastname: Healiss
authors.forename: D
authors.initials: D
authors.lastname: Desai
authors.forename: I
authors.initials: I
authors.lastname: Mustaq
authors.forename: P
authors.initials: P
authors.lastname: Cuckow
authors.forename: P
authors.initials: P
authors.lastname: Duffy
authors.forename: A
authors.initials: A
authors.lastname: Cherian
mesh_terms: D017677:Age Distribution; D000714:Anastomosis, Surgical; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000601:surgery*; D015994:Incidence; D008297:Male; D011182:Postoperative Care / Q000379:methods; D019651:Plastic Surgery Procedures / Q000009:adverse effects* / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D013997:Time Factors; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000002:abnormalities / Q000601:surgery*; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology
chemical_list: D014805:Vitamin B 12