title: Hydrophilic mesoporous carbon nanoparticles as carriers for sustained release of hydrophobic anti-cancer drugs.
abstract: The uniform mesoporous carbon nanoparticles (MCNs) with size below 200 nm and good water dispersibility were successfully synthesized via a combined hydrothermal synthesis and hard templating. The prepared MCNs served as effective carriers for camptothecin which efficiently inhibited the growth of MCF-7 cancer cells after its sustained release therein.
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. jinlougu@ecust.edu.cn
authors.forename: Jinlou
authors.initials: J
authors.lastname: Gu
authors.forename: Shasha
authors.initials: S
authors.lastname: Su
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Li
authors.forename: Qianjun
authors.initials: Q
authors.lastname: He
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy*; D002166:Camptothecin / Q000008:administration & dosage* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D002244:Carbon; D002166:Camptothecin