title: Development of Pd/C-catalyzed cyanation of aryl halides.
abstract: A practical method for palladium-catalyzed cyanation of aryl halides using Pd/C is described. The new method can be applied to a variety of aryl bromide and active aryl chloride substrates to effect efficient conversions. The process features many advantages over existing cyanation conditions and the practical utility of the process has been demonstrated on scale.
authors.affiliation: Chemical Product Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.
authors.forename: Hannah
authors.initials: H
authors.lastname: Yu
authors.forename: Rachel N
authors.initials: RN
authors.lastname: Richey
authors.forename: William D
authors.initials: WD
authors.lastname: Miller
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Xu
authors.forename: Scott A
authors.initials: SA
authors.lastname: May
mesh_terms: D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D009570:Nitriles; D010165:Palladium