title: Re-evaluating the general(ized) roles of AMPK in cellular metabolism.
abstract: AMPK is a protein kinase activated by various cellular stresses such as glucose deprivation, hypoxia or exercise. Despite having been studied for decades only a limited number of targets have been well described in tissues as varied as liver, muscle, and adipose tissue. Recent studies have shown that AMPK does not function in a similar manner, or through identical targets, in all cellular situations, posing challenges to some accepted paradigms describing AMPK function. A combination of genetic models and cell biological analysis of AMPK function in specific cell/developmental/environmental contexts will be required to accurately complement our understanding of the role(s) of AMPK in cancer, diabetes and other diseases.
authors.affiliation: Department of Biology-DBRI, McGill University, Montreal, QC, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Mantovani
authors.forename: Richard
authors.initials: R
authors.lastname: Roy
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D002477:Cells / Q000201:enzymology / Q000378:metabolism*; D006801:Humans
chemical_list: D000263:Adenylate Kinase