title: Exploratory study of a KLK2 polymorphism as a prognostic marker in prostate cancer.
abstract: OBJECTIVE
  An association of a single nucleotide polymorphism (SNP) of the KLK2 gene (rs198977; c.748C>T; R250W) with risk for developing prostate cancer has been observed. We evaluated the role of R250W SNP for prognosis in prostate cancer.
  
  
  METHODS
  The c.748C>T SNP was genotyped from blood DNA of 182 patients after completing initial cancer treatments. For evaluating prognosis of genotype groups, associations were performed with Gleason score (GS) and biochemical recurrence free survival (bRFS) in patients demonstrating PSA-recurrence after initial cancer therapy.
  
  
  RESULTS
  Overall distribution of the CC, CT and TT genotypes for the SNP was 48%, 44% and 8%, respectively. The distribution of high (8-10), moderate (5-7) and low (2-4) GS among the genotype groups was 17%, 74% and 9% for CC group compared to 25%, 74% and 1% for the CT/TT (P=0.04). Median bRFS time for CT/TT group was 36.5 months compared to 44.5 months for the CC group (P=0.16), while genotype groups combined with morphology revealed significantly different bRFS (P=0.004).
  
  
  CONCLUSIONS
  This exploratory analysis in prostate cancer patients revealed the W allele of the KLK2 R250W SNP to be less likely associated with low GS morphology. Further studies will be needed to confirm this observation in larger cohorts.
authors.affiliation: Department of Oncology, Mayo Clinic, Rochester, MN, USA. kohli.manish@mayo.edu
authors.forename: Manish
authors.initials: M
authors.lastname: Kohli
authors.forename: Paul G
authors.initials: PG
authors.lastname: Rothberg
authors.forename: Changyong
authors.initials: C
authors.lastname: Feng
authors.forename: Edward
authors.initials: E
authors.lastname: Messing
authors.forename: Jean
authors.initials: J
authors.lastname: Joseph
authors.forename: Sreevidya Sadasiva
authors.initials: SS
authors.lastname: Rao
authors.forename: Allison
authors.initials: A
authors.lastname: Hendershot
authors.forename: Deepak
authors.initials: D
authors.lastname: Sahsrabudhe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D018572:Disease-Free Survival; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000097:blood* / Q000235:genetics*; D012008:Recurrence; D020840:Tissue Kallikreins / Q000097:blood / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D020840:Tissue Kallikreins