title: Narrow-banding images and structures of microvessels of colonic lesions.
abstract: BACKGROUND
  Magnifying colonoscopy with NBI has been shown to be useful for the differential diagnosis of tumors. However, the relationship between findings on NBI magnification and the microvessel architecture of colorectal lesions remains to be clarified.
  
  
  OBJECTIVE
  The aim of this study was to clarify the correlation between NBI findings and the microvascular architecture of colorectal lesions according to the depth of microvessels from the mucosal surface.
  
  
  METHODS
  A total of 22 colorectal lesions (11 tubular adenomas and 11 hyperplasia) obtained from 22 patients were studied. These lesions were analyzed microscopically on tissue specimens immunostained with CD34. Three-dimensional images were reconstructed from serial sections of tubular adenomas, hyperplasia, and normal mucosa.
  
  
  RESULTS
  Three-dimensional reconstructed images of tubular adenoma and normal mucosa to a depth of less than 150 μm from the mucosal surface showed similar structures to images obtained by NBI magnification. Microvessel diameter was significantly larger in tubular adenoma than in normal mucosa (P = 0.002) and hyperplasia (P = 0.034), and microvessel area was significantly larger in tubular adenoma than in normal mucosa (P < 0.001) and hyperplasia (P < 0.001) only in the superficial mucosal layer (to a depth of less than 150 μm).
  
  
  CONCLUSIONS
  TA was characterized by thicker microvessels and higher volume of microvessels than NM and HP. Compared with white light, NBI can more accurately depict the characteristics of microvessels because it uses light with short wavelengths, thereby contributing to high diagnostic capability.
authors.affiliation: Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki-chuo, Tsuduki-ku, Yokohama-city 224-8503, Japan. kenken_mjp@yahoo.co.jp
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Mizuno
authors.forename: Shin-ei
authors.initials: SE
authors.lastname: Kudo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ohtsuka
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Hamatani
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Wada
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Inoue
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000473:pathology; D000328:Adult; D000368:Aged; D003106:Colon / Q000098:blood supply; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007413:Intestinal Mucosa / Q000098:blood supply; D008297:Male; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged