title: Churg-Strauss syndrome complicated by neuropathy: a clinicopathological study of nine cases.
abstract: OBJECTIVE
  The purpose of this study was to investigate the clinical, electrophysiological and pathological features of Churg Strauss syndrome (CSS) neuropathy.
  
  
  METHODS
  Biopsies were selected from over 700 sural nerve biopsies. The diagnosis of vasculitis was based on established clinicopathological criteria. Complete laboratory, clinical, electrophysiological and pathological studies were performed in all cases.
  
  
  RESULTS
  Nerve biopsies of 9 patients were diagnosed as Churg-Strauss syndrome. The pathological features were vasculitis with predominant axonal degeneration and a varying pattern of myelinated fiber loss. The vasculitic changes were found mainly in small epineural blood vessels. Mononeuritis multiplex and distal symmetrical and asymmetrical sensorimotor neuropathy, were equally frequent.
  
  
  CONCLUSIONS
  We conclude that, Churg-Strauss syndrome complicated frequently with polyneuropathy, and as remission depends on immunosuppressive therapy, it is important to recognize it in the early stage. The diagnosis of polyneuropathy is based on clinical and electrophysiologic studies, but precise histology, immunolohistochemistry and morphometric study of the peripheral nerve biopsy may be decisive in establishing the diagnosis.
authors.affiliation: Section of Neuropathology, Neurological Clinic of University of Athens, Aeginition Hospital, Athens, Greece. ekarariz@med.uoa.gr
authors.forename: E
authors.initials: E
authors.lastname: Kararizou
authors.forename: P
authors.initials: P
authors.lastname: Davaki
authors.forename: K
authors.initials: K
authors.lastname: Spengos
authors.forename: N
authors.initials: N
authors.lastname: Karandreas
authors.forename: A
authors.initials: A
authors.lastname: Dimitracopoulos
authors.forename: D
authors.initials: D
authors.lastname: Vassilopoulos
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents