title: Structural insight on processivity, human disease and antiviral drug toxicity.
abstract: DNA polymerase gamma (Pol γ) is a nuclear encoded, mitochondrially located replicase that conducts all DNA synthesis in the organelle. Structurally, human Pol γ closely resembles bacteriophage T7 DNA polymerase. Perhaps due to this prokaryotic-like feature, Pol γ is highly susceptible to inhibition by drugs designed against HIV reverse transcriptase and HCV RNA polymerase. In this review, I summarize recent structural and biochemical studies towards understanding Pol γ-mediated antiviral drug toxicity.
authors.affiliation: University of Texas at Austin, Austin, TX 78712, USA. whitney.yin@cm.utexas.edu
authors.forename: Y Whitney
authors.initials: YW
authors.lastname: Yin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects* / Q000737:chemistry* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000009:adverse effects* / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D019384:Nucleic Acid Synthesis Inhibitors; D013329:Structure-Activity Relationship; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors