title: Anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus.
abstract: In the present study, we investigated the anti-fatigue activity in male Kunming mice of extracts of stem bark from Acanthopanax senticosus (ASSE) using a forced swimming test. Mice were divided into four groups (three ASSE administered groups and the control group). The control group were gavaged with distilled water and ASSE administered groups were gavaged with ASSE (100, 200 and 400 mg/kg). After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined. The results suggested that ASSE could extend the swimming time to exhaustion of the mice, as well as increase the tissue glycogen contents, while decreasing the blood lactate and serum urea nitrogen contents. This indicated that ASSE had anti-fatigue activity and could elevate the exercise tolerance.
authors.affiliation: Physical Education College, Zhengzhou University, Zhengzhou 450044, China.
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Ren-Tao
authors.initials: RT
authors.lastname: Ding
authors.forename: Qiu-Sheng
authors.initials: QS
authors.lastname: Zhou
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Liu
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D028001:Eleutherococcus / Q000737:chemistry*; D005221:Fatigue / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D018547:Plant Stems / Q000737:chemistry*; D013550:Swimming
chemical_list: D010936:Plant Extracts