title: Lipid membranes supported on optically transparent nanosilicas: synthesis and application in characterization of protein-membrane interactions.
abstract: We describe methods of preparation of lipid membranes supported on optically transparent nanosilicas (20 and 30 nm diameter) and an initial application of these materials to characterize membrane-protein binding using conventional circular dichroism and fluorescence spectroscopy.
authors.affiliation: Department of Chemistry and Biochemistry, Seton Hall University South Orange, New Jersey 07079, USA. alexander.fadeev@shu.edu
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Fadeev
authors.forename: William F
authors.initials: WF
authors.lastname: DeGrado
mesh_terms: D002942:Circular Dichroism; D008555:Melitten / Q000378:metabolism*; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry; D055620:Optical Phenomena; D011485:Protein Binding; D017433:Protein Structure, Secondary; D012822:Silicon Dioxide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D053835:Unilamellar Liposomes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D053835:Unilamellar Liposomes; D008555:Melitten; D012822:Silicon Dioxide