title: The essential role of DOCK8 in humoral immunity.
abstract: The processes that normally generate and maintain adaptive immunity and immunological memory are poorly understood, and yet of fundamental importance when infectious diseases place such a major economic and social burden on the world's health and agriculture systems. Defects in these mechanisms also underlie the many forms of human primary immunodeficiency. Identifying these mechanisms in a systematic way is therefore important if we are to develop better strategies for treating and preventing infection, inherited disease, transplant rejection and autoimmunity. In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two independent DOCK8 mutant mice strains identified by this screen. DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse.
authors.affiliation: John Curtin School of Medical Research, The Australian National University, Canberra ACT, Australia.
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Randall
authors.forename: Teresa
authors.initials: T
authors.lastname: Lambe
authors.forename: Chris C
authors.initials: CC
authors.lastname: Goodnow
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Cornall
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D005038:Ethylnitrosourea; D055106:Genome-Wide Association Study; D018858:Germinal Center / Q000276:immunology / Q000473:pathology; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000276:immunology; D056724:Immunity, Humoral; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000473:pathology; D007156:Immunologic Memory; D054992:Immunological Synapses / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation
chemical_list: D000906:Antibodies; C545324:Dock8 protein, mouse; D020662:Guanine Nucleotide Exchange Factors; D005038:Ethylnitrosourea