title: Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements.
abstract: Studies of canine models of Duchenne muscular dystrophy (DMD) provide insight regarding disease pathogenesis and treatment efficacy. To take maximal advantage, colonies of affected dogs must be maintained and outcome parameters developed. In this chapter, we review our 25 years of experience with the golden retriever muscular dystrophy (GRMD) model. Key challenges in colony development (breeding, neonatal death, and the risk of inbreeding) and representative functional measurements (tibiotarsal joint angle and torque force; and eccentric contraction decrement) are discussed.
authors.affiliation: Department of Pathology and Laboratory Medicine and The Gene Therapy Center, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA. joe_kornegay@med.unc.edu
authors.forename: Joe N
authors.initials: JN
authors.lastname: Kornegay
authors.forename: Janet R
authors.initials: JR
authors.lastname: Bogan
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Bogan
authors.forename: Martin K
authors.initials: MK
authors.lastname: Childers
authors.forename: Robert W
authors.initials: RW
authors.lastname: Grange
mesh_terms: D000818:Animals; D001947:Breeding; D004195:Disease Models, Animal; D004285:Dogs; D016189:Dystrophin / Q000172:deficiency; D053580:Muscle Strength / Q000502:physiology*; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology; D009137:Muscular Dystrophy, Animal / Q000401:mortality / Q000503:physiopathology*; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology
chemical_list: D016189:Dystrophin