title: Correlation between circulating adhesion molecules and resistin levels in hypertensive type-2 diabetic patients.
abstract: BACKGROUND
  Endothelial dysfunction, a common feature among hypertensive and type-2 diabetic patients, has been associated with inflammation and increased concentrations of serum soluble adhesion molecules and resistin, a monocyte-macrophage- and adipocyte-derived cytokine.
  
  
  OBJECTIVE
  To determine if there is a correlation between the serum concentrations of ICAM-1, VCAM-1, Eselectin and resistin in hypertensive type-2 diabetic patients.
  
  
  METHODS
  Thirty hypertensive type-2 diabetic patients were enrolled in the study. Serum ICAM-1, VCAM-1, E-selectin and resistin concentrations were determined by ELISA and correlated with the Spearman correlation coefficient.
  
  
  RESULTS
  The patients' serum resistin concentrations significantly correlated with VCAM-1 (r = 0.31, p= 0.05) concentrations but not with ICAM-1 (r = 0.29, p = >0.05) and E-selectin (r = 0.10, p = 0.24) concentrations.
  
  
  CONCLUSIONS
  VCAM-1 and resistin may participate in the pathophysiology of vascular damage in hypertensive type-2 diabetic patients. Serum resistin concentrations may be a marker of endothelial dysfunction.
authors.affiliation: Hypertension Clinic, Hospital General de Ticomán, SS DF, México.
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Lozano-Nuevo
authors.forename: Teresa
authors.initials: T
authors.lastname: Estrada-Garcia
authors.forename: Hilda
authors.initials: H
authors.lastname: Vargas-Robles
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Escalante-Acosta
authors.forename: Alberto F
authors.initials: AF
authors.lastname: Rubio-Guerra
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D019040:E-Selectin / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008800:Mexico; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D019040:E-Selectin; C499624:RETN protein, human; D052243:Resistin; C546936:SELE protein, human; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1