title: Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease.
abstract: The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm- tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy.
authors.affiliation: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
authors.forename: Yong Soon
authors.initials: YS
authors.lastname: Chun
authors.forename: Pooja
authors.initials: P
authors.lastname: Chaudhari
authors.forename: Yoon-Young
authors.initials: YY
authors.lastname: Jang
mesh_terms: D064987:Cell- and Tissue-Based Therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D015316:Genetic Therapy; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology* / Q000628:therapy