title: γδ T cells and multiple sclerosis: Friends, foes, or both?
abstract: Multiple sclerosis (MS) is a debilitating CNS disease characterized by demyelination and neuro-axonal loss. Though the exact etiology is still unknown, accumulated evidence points to the immune system being involved in the MS disease-process. Both ill-fated adaptive and innate immune responses can potentially contribute to the etiopathogenesis. We have been interested in deciphering how innate immunity might be involved; in particular, the role of γδ T cells. In this review, we discuss the current understanding about γδ T cells and describe the evidence implicating them in myelin injury, neurotoxicity, and immunoregulation in the development of MS.
authors.affiliation: Department of Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Chen
authors.forename: Mark S
authors.initials: MS
authors.lastname: Freedman
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*