title: IL-17 in protective immunity to intracellular pathogens.
abstract: The identification of a new T cell subset referred to as T helper 17 (Th17) cells and its role in protective immunity against extracellular bacterial infections is well established. In contrast, initial studies suggested that the IL-23-IL-17 pathway was not required for protection against intracellular pathogens such as mycobacterial infections. However, recent studies demonstrate that Th17-IL-23 pathway may play a crucial role in protective immunity against other intracellular pathogens by regulating the innate and adaptive immune responses. The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here.
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Shabaana.Khader@chp.edu
authors.forename: Shabaana A
authors.initials: SA
authors.lastname: Khader
authors.forename: Radha
authors.initials: R
authors.lastname: Gopal
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D023502:Chlamydia muridarum / Q000276:immunology / Q000472:pathogenicity; D005604:Francisella tularensis / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D053759:Interleukin-23 / Q000276:immunology; D008954:Models, Biological; D009163:Mycobacterium bovis / Q000276:immunology / Q000472:pathogenicity; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000472:pathogenicity; D012486:Salmonella typhimurium / Q000276:immunology / Q000472:pathogenicity; D058504:Th17 Cells / Q000276:immunology
chemical_list: D020381:Interleukin-17; D053759:Interleukin-23