title: Perfusion Imaging with SPECT in the Era of Pathophysiology-Based Biomarkers for Alzheimer's Disease.
abstract: SPECT allows registration of regional cerebral blood flow (rCBF) which is altered in a characteristic temporoparietal pattern in Alzheimer's Dementia. Numerous studies have shown the diagnostic value of reduced cerebral blood flow and metabolic changes using perfusion SPECT and FDG-PEPT in AD diagnosis as well as in differential diagnosis against frontotemporal dementia, dementia with Lewy bodies and vascular disease. Recently more pathophysiology-based biomarkers in CSF and Amyloid-PET tracers have been developed that probably have a higher diagnostic accuracy than the more indirect rCBF changes seen in perfusion SPECT. In the paper review, we describe recent advances in AD biomarkers as well as improvements in the SPECT technique.
authors.affiliation: Department for Psychiatry and Psychiatry, University of Erlangen-Nuermberg, Schwabachanlage 6, 91054 Erlangen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Weih
authors.forename: Umüt
authors.initials: U
authors.lastname: Degirmenci
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kreil
authors.forename: Piotr
authors.initials: P
authors.lastname: Lewczuk
authors.forename: Daniela
authors.initials: D
authors.lastname: Schmidt
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
authors.forename: Torsten
authors.initials: T
authors.lastname: Kuwert