title: The effect of aloe vera oral administration on cutaneous wound healing in type 2 diabetic rats.
abstract: Delayed wound healing is one of the complications of diabetes mellitus. The present study was performed to investigate the effect of Aloe vera oral administration on open wounds in type 2 diabetic rats. Full thickness open wounds (1.5 × 1.5 cm) were created under general anesthesia on the backs of the rats. These rats were divided into two group, a control group (Group C) and an Aloe vera oral administration group (Group A). Each wound area was measured on days 1, 2, 4 and 8 postwounding. The stages of wound granulation tissues were evaluated histopathologically. The expression of transforming growth factor (TGF)-β1 and vascular endothelial growth factor (VEGF) were determined by immunohistochemically. The wounds were significantly contracted in Group A on days 2, 4 and 8 postwounding. Histological results revealed that the inflammatory cell infiltration, angiogenesis, extracellular matrix deposition and epithelialization were promoted in Group A, respectively. The immunohistochemical results revealed that both TGF-β1 and VEGF protein-positive cells increased in Group A on day 4 postwounding. We concluded that Aloe vera oral administration accelerated wound healing in type 2 diabetic rats.
authors.affiliation: The United Graduate School of Veterinary Sciences, Gifu University.
authors.forename: Ayman
authors.initials: A
authors.lastname: Atiba
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueno
authors.forename: Yuji
authors.initials: Y
authors.lastname: Uzuka
mesh_terms: D000284:Administration, Oral; D000504:Aloe; D000818:Animals; D003924:Diabetes Mellitus, Type 2; D005786:Gene Expression Regulation / Q000502:physiology; D010946:Plants, Medicinal; D011208:Powders; D051381:Rats; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
chemical_list: D011208:Powders; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A