title: Increased fractional anisotropy in white matter of the right frontal region in children with attention-deficit/hyperactivity disorder: a diffusion tensor imaging study.
abstract: Abnormalities of frontal white matter (WM) have been found in some children with ADHD. The purpose of this study was to explore the changes in WM in child patients with ADHD by DTI, which detects changes in WM microstructure based on properties of diffusion. We also expect to investigate the relationship between the changes in WM and executive function in child patients with ADHD. DTI was performed on 24 patients with ADHD and 20 healthy controls. A series of neuropsychological tests and a structural interview were conducted to assess the cognitive functions and clinical data of the ADHD patients and controls. Firstly, child patients with ADHD have higher fractional anisotropy (FA) values in WM in the right frontal region. Secondly, FA in right frontal WM is positively correlated with scores in the Stroop test.
  
  
  CONCLUSIONS
  Increased FA of right frontal WM implies a higher degree of myelination and lower degree of neural branching in WM, contributing to the neurological deficits of ADHD.
authors.affiliation: Department of Psychiatry, Sichuan University, Guo Xue Xiang No.37, Chengdu, 610041, Sichuan Province, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Li
authors.forename: Jinhua
authors.initials: J
authors.lastname: Sun
authors.forename: Lanting
authors.initials: L
authors.lastname: Guo
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
authors.forename: Zhengzhi
authors.initials: Z
authors.lastname: Feng
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Yating
authors.initials: Y
authors.lastname: Lv
authors.forename: Mingjin
authors.initials: M
authors.lastname: Huang
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D016880:Anisotropy; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000473:pathology* / Q000523:psychology*; D016022:Case-Control Studies; D002648:Child; D003071:Cognition; D056324:Diffusion Tensor Imaging; D056344:Executive Function; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests