title: [Outcome of patients with non-ST segment elevation acute coronary syndrome undergoing early or delayed intervention].
abstract: OBJECTIVE
  To compare the effect and safety of early intervention and delayed intervention in patients with non-ST segment elevation acute coronary syndrome.
  
  
  METHODS
  In this multicenter randomized trial, patients diagnosed as non-ST segment elevation acute coronary syndrome were randomly assigned to undergo early intervention (coronary angiography ≤ 24 hours after randomization, n = 446) or delayed intervention (coronary angiography ≥ 36 hours after randomization, n = 369). The primary outcome was a composite of death, myocardial infarction or stroke at 180 days. The secondary outcome was death, myocardial infarction, refractory ischemia, stroke or revascularization at 180 days.
  
  
  RESULTS
  Baseline clinical characteristics were comparable between the two groups. Incidence of both primary (9.0% vs. 14.6%, P = 0.01) and secondary which was a composite of death, myocardial infarction or refractory ischemia (14.6% vs. 22.0% P = 0.01) endpoints were significantly lower in early intervention group than in delayed intervention group. Incidence of myocardial infarction was significantly lower in early intervention group than in delayed intervention group (5.2% vs. 10.8%, P = 0.00). Another secondary outcome which was a composite of death, myocardial infarction, refractory ischemia, stroke or revascularization was similar between the two groups (26.7% vs. 30.4%, P = 0.25).
  
  
  CONCLUSIONS
  Compared to delayed intervention group, early intervention reduced incidence of myocardial infarction but did not affect the incidence of death, stroke or refractory ischemia in patients with non-ST segment elevation acute coronary syndrome.
authors.affiliation: Chinese Academy of Medical Sciences, Beijing 100037, China. zhangjun-cv@263.net
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Shu-bin
authors.initials: SB
authors.lastname: Qiao
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
mesh_terms: D054058:Acute Coronary Syndrome / Q000503:physiopathology / Q000628:therapy*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome