title: Novel antifouling oligo(ethylene glycol) methacrylate particles via surfactant-free emulsion polymerization.
abstract: The use of particle formulations with antifouling surface properties attracts increasing interest in several biotechnological applications. Majority of these studies utilize a poly(ethylene glycol) coating to render the corresponding surface nonrecognizable to biological macromolecules. Herein, we report a simple way to prepare novel antifouling colloids composed of oligo(ethylene glycol) backbones via surfactant-free emulsion polymerization. Monodisperse cross-linked poly(ethylene glycol) ethyl ether methacrylate particles were characterized by dynamic light scattering and transmission electron microscopy. The effects of monomer, cross-linker and initiator on particle characteristics were investigated. More importantly, a prominent blockage of bovine serum albumin adsorption was obtained for the poly(ethylene glycol)-based sub-micron (~200 nm) particles when compared with similar-sized poly(methyl methacrylate) counterparts.
authors.affiliation: Nanomedicine and Advanced Technologies Research Center, Gazi University, 06830 Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Buyukserin
authors.forename: Sevket Tolga
authors.initials: ST
authors.lastname: Camli
authors.forename: Mustafa Selman
authors.initials: MS
authors.lastname: Yavuz
authors.forename: Gurer Guven
authors.initials: GG
authors.lastname: Budak
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D003102:Colloids / Q000737:chemistry* / Q000378:metabolism; D004202:Disinfectants; D004655:Emulsions / Q000737:chemistry; D019855:Ethylene Glycol / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D019904:Polymethyl Methacrylate / Q000737:chemistry* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013499:Surface Properties; D013501:Surface-Active Agents
chemical_list: D003102:Colloids; D004202:Disinfectants; D004655:Emulsions; D013501:Surface-Active Agents; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D019904:Polymethyl Methacrylate; D019855:Ethylene Glycol