title: Substance P is a key mediator of stress-induced protection from allergic sensitization via modified antigen presentation.
abstract: Interaction between the nervous and immune systems greatly contributes to inflammatory disease. In organs at the interface between our body and the environment, the sensory neuropeptide substance P (SP) is one key mediator of an acute local stress response through neurogenic inflammation but may also alter cytokine balance and dendritic cell (DC) function. Using a combined murine allergic inflammation/noise stress model with C57BL/6 mice, we show in this paper that SP--released during repeated stress exposure--has the capacity to markedly attenuate inflammation. In particular, repeated stress exposure prior to allergen sensitization increases DC-nerve fiber contacts, enhances DC migration and maturation, alters cytokine balance, and increases levels of IL-2 and T regulatory cell numbers in local lymph nodes and inflamed tissue in a neurokinin 1-SP-receptor (neurokinin-1 receptor)-dependent manner. Concordantly, allergic inflammation is significantly reduced after repeated stress exposure. We conclude that SP/repeated stress prior to immune activation acts protolerogenically and thereby beneficially in inflammation.
authors.affiliation: University-Medicine Charité, Charité Center 12 for Internal Medicine and Dermatology, D-10117 Berlin, Germany.
authors.forename: Sanja
authors.initials: S
authors.lastname: Pavlovic
authors.forename: Christiane
authors.initials: C
authors.lastname: Liezmann
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Blois
authors.forename: Ricarda
authors.initials: R
authors.lastname: Joachim
authors.forename: Johannes
authors.initials: J
authors.lastname: Kruse
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Romani
authors.forename: Burghard F
authors.initials: BF
authors.lastname: Klapp
authors.forename: Eva M J
authors.initials: EM
authors.lastname: Peters
mesh_terms: D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D002478:Cells, Cultured; D018920:Coculture Techniques; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D017449:Dermatitis, Allergic Contact / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000009:adverse effects; D005260:Female; D018836:Inflammation Mediators / Q000502:physiology*; D007801:Langerhans Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009622:Noise / Q000009:adverse effects; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D010865:Pilot Projects; D011897:Random Allocation; D013312:Stress, Physiological / Q000276:immunology*; D013373:Substance P / Q000502:physiology*
chemical_list: D000485:Allergens; D018836:Inflammation Mediators; D013373:Substance P; D010047:Ovalbumin