title: Outcome of fetuses with cerebral ventriculomegaly and septum pellucidum leaflet abnormalities.
abstract: OBJECTIVE
  The objective of this study was to assess the outcomes of the prenatal diagnosis of septal leaflet abnormalities in fetuses referred for prenatal imaging with a finding of ventriculomegaly.
  
  
  METHODS
  This study is a retrospective review of fetuses with a diagnostic code of septal leaflet abnormalities from a larger prospective study. Four hundred twenty-five pregnant women with 433 fetuses referred for ventriculomegaly were imaged with ultrasound and MRI between July 1, 2003, and May 15, 2009. Four to six radiologists independently reviewed sonographic and MR images and recorded lateral ventricular diameters at the atrium and frontal horns, ventricular configuration, and the presence of ventriculomegaly and of other CNS abnormalities. Final prenatal ultrasound, MRI, and overall diagnoses were decided by consensus. Fetuses with a diagnostic code of septal leaflet abnormalities were identified, and birth outcome, autopsy findings, postnatal imaging, and postnatal follow-up examinations were obtained. The analysis of covariance, controlling for gestational age, was used to compare ventricular dimensions between fetuses with septal leaflet abnormalities and fetuses with isolated ventriculomegaly. Interrater agreement for the detection of septal leaflet abnormalities was assessed with kappa statistics. Interrater agreement and intrarater agreement for frontal horn measurements were assessed by variance components analysis.
  
  
  RESULTS
  Twenty-three fetuses had septal leaflet abnormalities and 229 had isolated ventriculomegaly. Atrial and frontal horn diameters, adjusted for gestational age, were 77% and 98% larger, respectively, in fetuses with septal leaflet abnormalities than in fetuses with isolated ventriculomegaly (p < 0.0001). Before the consensus conference, agreement among ultrasound readers was moderate (κ = 0.54) and among MR readers, good (κ = 0.69). Additional CNS findings were seen on MRI in 12 of 23 fetuses (52%). Eleven pregnancies with septal leaflet abnormalities underwent termination and 12 progressed to livebirth; of the 12 livebirths, three neonates died. Neurodevelopmental follow-up was abnormal in all surviving children.
  
  
  CONCLUSIONS
  A septal leaflet abnormality in the setting of ventriculomegaly is most frequently associated with other CNS abnormalities and is associated with postnatal developmental delay.
authors.affiliation: Harvard Medical School, Boston, MA, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Rakhee K
authors.initials: RK
authors.lastname: Sansgiri
authors.forename: Judy A
authors.initials: JA
authors.lastname: Estroff
authors.forename: Tejas S
authors.initials: TS
authors.lastname: Mehta
authors.forename: Tina Y
authors.initials: TY
authors.lastname: Poussaint
authors.forename: Richard L
authors.initials: RL
authors.lastname: Robertson
authors.forename: Caroline D
authors.initials: CD
authors.lastname: Robson
authors.forename: Henry A
authors.initials: HA
authors.lastname: Feldman
authors.forename: Carol
authors.initials: C
authors.lastname: Barnewolt
authors.forename: Deborah
authors.initials: D
authors.lastname: Levine
mesh_terms: D000704:Analysis of Variance; D002552:Cerebral Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005865:Gestational Age; D006801:Humans; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000000981:diagnostic imaging; D018709:Statistics, Nonparametric; D016216:Ultrasonography, Prenatal