title: Relationship Between Earlobe Crease and Brachial-ankle Pulse Wave Velocity in Non-hypertensive, Non-diabetic Adults in Korea.
abstract: OBJECTIVE
  Several studies have found a significant association between the presence of earlobe crease (ELC) and cardiovascular disease (CVD). Brachial-ankle Pulse Wave Velocity (baPWV) is a non-invasive and useful measure of arterial stiffness predicting cardiovascular events and mortality. However, few studies have reported the relationship between ELC and baPWV as a new measure of arterial stiffness. The purpose of this study was to determine whether ELC is related to baPWV in non-diabetic, non-hypertensive, and apparently healthy Korean adults.
  
  
  METHODS
  A cross-sectional study was conducted on 573 non-hypertensive, non-diabetic Korean adults aged 20-80 yr. Subjects were stratified into three groups according to gender and menopausal status. baPWV was measured by an automatic waveform analyser. The association between ELC and baPWV was assessed by multiple linear regression analysis after adjusting for conventional cardiovascular disease risk factors including age, gender, blood pressure, lipid profile, and smoking status etc.
  
  
  RESULTS
  The overall frequency of ELC was 19.02% and the subjects with ELC showed significantly higher mean baPWV (p<0.0001). Multiple linear regression of subjects revealed that the presence of ELC was independently associated with baPWV (male, p<0.0001; premenopausal female p=0.0162; postmenopausal female p=0.0208).
  
  
  CONCLUSIONS
  ELC had a significant correlation with baPWV, independently controlling for other classical cardiovascular risk factors in adults aged 20 yr or older. ELC is an important surrogate marker of increased arterial stiffness as measured by baPWV in Korean adults.
authors.affiliation: Department of Family Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
authors.forename: Sang In
authors.initials: SI
authors.lastname: Choi
authors.forename: Hee Cheol
authors.initials: HC
authors.lastname: Kang
authors.forename: Choon Ok
authors.initials: CO
authors.lastname: Kim
authors.forename: Seung Beom
authors.initials: SB
authors.lastname: Lee
authors.forename: Won Ju
authors.initials: WJ
authors.lastname: Hwang
authors.forename: Dae Ryong
authors.initials: DR
authors.lastname: Kang