title: Microwave assisted synthesis and biological activity of novel coumarinyltriazolothiadiazoles.
abstract: A series of new 3-(4-methylcoumarinyl-7-oxymethyl)-6-substitutedphenyl-5,6-dihydro-s-triazolo (3,4-b)(1,3,4)-thiadiazoles 2(a-j) have been synthesized by reacting 5-(4-methyl coumarinyl-7-oxymethyl)-4-amino-3-mercapto(4H)-1,2,4-triazole with various aromatic aldehydes by microwave assisted organic synthesis. The structure of the compounds 2 (a-j) has been confirmed by IR, (1)H NMR and mass spectral data. All the compounds were screened for antimicrobial and antioxidant activity. Among the compounds tested, compounds 2d (4-dimethyl amino phenyl derivative) and 2h (3,4-dimethoxy phenyl derivative) showed better antimicrobial and antioxidant activity than rest of the compounds in the series.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, 395, Sarojini Naidu Road, Coimbatore-641 044, India.
authors.forename: P Manoj
authors.initials: PM
authors.lastname: Kumar
authors.forename: T K
authors.initials: TK
authors.lastname: Ravi
authors.forename: R
authors.initials: R
authors.lastname: Chawla
authors.forename: S
authors.initials: S
authors.lastname: Bhuvana
authors.forename: G
authors.initials: G
authors.lastname: Sonia
authors.forename: S
authors.initials: S
authors.lastname: Gopalakrishnan