title: Synthesis, bioactivity and preliminary biocompatibility studies of glasses in the system CaO-MgO-SiO2-Na2O-P2O5-CaF2.
abstract: New compositions of bioactive glasses are proposed in the CaO-MgO-SiO(2)-Na(2)O-P(2)O(5)-CaF(2) system. Mineralization tests with immersion of the investigated glasses in simulated body fluid (SBF) at 37°C showed that the glasses favour the surface formation of hydroxyapatite (HA) from the early stages of the experiments. In the case of daily renewable SBF, monetite (CaHPO(4)) formation competed with the formation of HA. The influence of structural features of the glasses on their mineralization (bioactivity) performance is discussed. Preliminary in vitro experiments with osteoblasts' cell-cultures showed that the glasses are biocompatible and there is no evidence of toxicity. Sintering and devitrification studies of glass powder compacts were also performed. Glass-ceramics with attractive properties were obtained after heat treatment of the glasses at relatively low temperatures (up to 850°C).
authors.affiliation: Department of Ceramics and Glass Engineering, University of Aveiro, CICECO, 3810-193, Aveiro, Portugal.
authors.forename: D U
authors.initials: DU
authors.lastname: Tulyaganov
authors.forename: S
authors.initials: S
authors.lastname: Agathopoulos
authors.forename: P
authors.initials: P
authors.lastname: Valerio
authors.forename: A
authors.initials: A
authors.lastname: Balamurugan
authors.forename: A
authors.initials: A
authors.lastname: Saranti
authors.forename: M A
authors.initials: MA
authors.lastname: Karakassides
authors.forename: J M F
authors.initials: JM
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001672:Biocompatible Materials / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry*; D002124:Calcium Fluoride / Q000737:chemistry*; D002478:Cells, Cultured; D005898:Glass; D008277:Magnesium Oxide / Q000737:chemistry*; D008956:Models, Chemical; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010087:Oxides / Q000737:chemistry*; D017553:Phosphorus Compounds / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012822:Silicon Dioxide / Q000737:chemistry*; D017670:Sodium Compounds / Q000737:chemistry*; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D010087:Oxides; D017553:Phosphorus Compounds; D017670:Sodium Compounds; C096707:sodium oxide; D008277:Magnesium Oxide; C012500:phosphorus pentoxide; D012822:Silicon Dioxide; C016538:lime; D002124:Calcium Fluoride