title: Pharmacology in childhood arterial ischemic stroke.
abstract: In recent years, there has been increasing recognition of the impact of childhood stroke and interest in the role of drugs in the acute, chronic, and prophylactic management of this condition. Most treatment strategies are based on studies in adults with stroke, and the relative infrequency of stroke and the heterogeneity of etiologies in childhood compared with adults present significant challenges in study design for childhood stroke studies. The presence of thrombophilia has been associated with stroke in children, strengthening the concept that antithrombotic, antiplatelet, and even thrombolytic agents have a role in stroke treatment and prevention. There are several potential roles for drugs in the treatment of childhood stroke including hyperacute therapy, antithrombotic medication, antiplatelet medication, and disease-specific medications. Herein, we review the use and rationale of these medications in childhood arterial ischemic stroke.
authors.affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53201, USA. KLefond@mcw.edu
authors.forename: Catherine
authors.initials: C
authors.lastname: Amlie-Lefond
authors.forename: Joan Cox
authors.initials: JC
authors.lastname: Gill
mesh_terms: D000367:Age Factors; D001158:Arteries / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy*; D002648:Child; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors