title: Cryptococcus gattii molecular type VGII as agent of meningitis in a healthy child in Rio de Janeiro, Brazil: report of an autochthonous case.
abstract: Cryptococcus gattii causes meningoencephalitis in immunocompetent hosts, occurring endemically in some tropical and subtropical regions. Recently, this fungus was involved in an outbreak in Vancouver Island and British Columbia (Canada). In this temperate region, the VGII type is predominant. The paper describes an autochthonous case of meningoencephalitis by C. gattii VGII in a previously health child in Rio de Janeiro, considered nonendemic region of Brazil. The fungus was identified by biochemical tests and the molecular type was determined by URA5-RFLP. The present report highlights the need for clinical vigilance for primary cryptococcal meningitis in nonendemic areas.
authors.affiliation: Oswaldo Cruz Foundation, Brasília, DF, Brazil. vitorlaerte@fiocruz.br
authors.forename: Vitor Laerte
authors.initials: VL
authors.lastname: Pinto Junior
authors.forename: Marcos Vinicius da Silva
authors.initials: MV
authors.lastname: Pone
authors.forename: Sheila Moura
authors.initials: SM
authors.lastname: Pone
authors.forename: João Maurício Scarpellini
authors.initials: JM
authors.lastname: Campos
authors.forename: José Roberto Pereira
authors.initials: JR
authors.lastname: Garrido
authors.forename: Ana Cláudia Mamede Wiering
authors.initials: AC
authors.lastname: de Barros
authors.forename: Luciana
authors.initials: L
authors.lastname: Trilles
authors.forename: Gláucia Gonçalves
authors.initials: GG
authors.lastname: Barbosa
authors.forename: Bernardina Penarrieta
authors.initials: BP
authors.lastname: Morales
authors.forename: Cláudia de Carvalho Falci
authors.initials: Cde C
authors.lastname: Bezerra
authors.forename: Márcia dos Santos
authors.initials: Mdos S
authors.lastname: Lazéra
mesh_terms: D002675:Child, Preschool; D056285:Cryptococcus gattii / Q000235:genetics*; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis* / Q000382:microbiology; D012150:Polymorphism, Restriction Fragment Length