title: Metabolic phenotype and adipose tissue inflammation in patients with chronic obstructive pulmonary disease.
abstract: Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age 62.3 ± 7.2 years). With increasing body mass index, increases in AT expressions of IL-6, TNF-α, and CD68 were observed (P < .001; P = .005; P < .001, resp.), in association with reduced insulin sensitivity (P < .001). No differences were observed between cachectic and normal-weight patients in AT expressions of inflammatory or proapoptotic markers. Adipose tissue CD68 and TNF-α expressions predicted insulin sensitivity independently of known confounders (P = .005; P = .025; R(2) = 0.840). Our results suggest that AT inflammation in obese COPD patients relates to insulin resistance. Cachectic patients remain insulin sensitive, with no AT upregulation of inflammatory or proapoptotic markers.
authors.affiliation: Department of Respiratory Medicine, Faculty of Medicine, P.J. Safarik University and L. Pasteur Teaching Hospital, 04001 Kosice, Slovakia.
authors.forename: Peter
authors.initials: P
authors.lastname: Skyba
authors.forename: Jozef
authors.initials: J
authors.lastname: Ukropec
authors.forename: Pavol
authors.initials: P
authors.lastname: Pobeha
authors.forename: Barbara
authors.initials: B
authors.lastname: Ukropcova
authors.forename: Pavol
authors.initials: P
authors.lastname: Joppa
authors.forename: Timea
authors.initials: T
authors.lastname: Kurdiova
authors.forename: Katarina
authors.initials: K
authors.lastname: Stroffekova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Brusik
authors.forename: Iwar
authors.initials: I
authors.lastname: Klimes
authors.forename: Ivan
authors.initials: I
authors.lastname: Tkac
authors.forename: Daniela
authors.initials: D
authors.lastname: Gasperikova
authors.forename: Ruzena
authors.initials: R
authors.lastname: Tkacova
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000368:Aged; D015703:Antigens, CD / Q000235:genetics; D015214:Antigens, Differentiation, Myelomonocytic / Q000235:genetics; D002100:Cachexia / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D053148:Caspase 3 / Q000235:genetics; D005260:Female; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D018836:Inflammation Mediators / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D050177:Overweight / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015434:Panniculitis / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D051028:bcl-2-Associated X Protein / Q000235:genetics; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D053148:Caspase 3; D018836:Inflammation Mediators; D015850:Interleukin-6; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha; D051028:bcl-2-Associated X Protein; C494826:BAX protein, human; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C508600:IL6 protein, human; C506235:TNFRSF1A protein, human; C505407:CASP3 protein, human