title: Multivariate linkage scan for metabolic syndrome traits in families with type 2 diabetes.
abstract: The purpose of this study was to evaluate evidence for linkage to interrelated quantitative features of the metabolic syndrome (MetS). Data on eight quantitative MetS traits (body weight, waist circumference, systolic and diastolic blood pressure, high-density lipoprotein (HDL) cholesterol, triglycerides (TGs), and fasting glucose and insulin measurements) and a 10 cM genome scan were available for 78 white families (n = 532 subjects). These data were used to conduct multipoint, multivariate linkage analyses, including tests for coincident linkage and complete pleiotropy. The strongest evidence for linkage from the bivariate analyses was observed on chromosome 1 (1p22.2) (HDL-TG; univariate lod score equivalent (lod(eq) = 3.99)) with stronger results from the trivariate analysis at the same location (HDL-TG-Insulin; lod(eq) = 4.32). Seven additional susceptibility regions (lod(eq) scores >1.9) were observed (1p36, 1q23, 2q21.2, 8q23.3, 14q23.2, 14q32.11, and 20p11.21). The results from this study indicate that several correlated traits of the MetS are influenced by the same gene(s) that account for some of the clustering of the MetS features.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA. keddy@u.washington.edu
authors.forename: Karen L
authors.initials: KL
authors.lastname: Edwards
authors.forename: Jia Y
authors.initials: JY
authors.lastname: Wan
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Hutter
authors.forename: Pui Yee
authors.initials: PY
authors.lastname: Fong
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Santorico
mesh_terms: D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D058685:Genetic Pleiotropy; D055106:Genome-Wide Association Study; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D008875:Middle Aged; D040641:Quantitative Trait Loci; D012984:Software; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood; D014481:United States; D044465:White People
chemical_list: D005819:Genetic Markers; C034396:HDL-triglyceride; D008075:Lipoproteins, HDL; D014280:Triglycerides