title: A pauci-symptomatic case of documented Hantavirus (Puumala) infection in a patient under anti-TNF treatment.
abstract: We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying sign or symptom or paraclinical abnormality despite extensive work-up performed in the context of his immunocompromised state. Symptoms disappeared after 10 days and a diagnosis of Puumala infection was made retrospectively on a serological basis. The case illustrates that anti-TNF treatment does not worsen the course of Puumala infection and could even be associated with a milder clinical picture.
authors.affiliation: Department of Infectious Diseases and General Internal Medicine, CHU de Liège, University of Liège. CHU Sart-Tilman, 4000 Liège, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Moutschen
authors.forename: M
authors.initials: M
authors.lastname: Bourhaba
authors.forename: F
authors.initials: F
authors.lastname: Frippiat
authors.forename: J B
authors.initials: JB
authors.lastname: Giot
authors.forename: C
authors.initials: C
authors.lastname: Meuris
authors.forename: P
authors.initials: P
authors.lastname: Léonard
authors.forename: M
authors.initials: M
authors.lastname: Moutschen
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D003424:Crohn Disease / Q000188:drug therapy; D006476:Orthohantavirus / Q000276:immunology*; D018778:Hantavirus Infections / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D012698:Serologic Tests; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000914:Antibodies, Viral; D007155:Immunologic Factors; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha