title: Effect of different frequencies of fluoride dentifrice and mouthrinse administration: an in situ study.
abstract: The effect of a combination of topical fluoridation methods for inhibition of enamel demineralization in the face of a cariogenic challenge has not been clearly established. This in situ crossover study aimed to assess whether the addition of daily use of fluoride mouthrinse (FR) to that of fluoride dentifrice (FD) is equivalent to increasing the frequency of FD application in terms of the effect on enamel demineralization and fluoride content. Over 3 phases of 14 days each, 12 volunteers wore appliances containing enamel blocks exposed to a 20 % sucrose solution 8 times/day. During each phase the blocks underwent one of the following treatments: 2x/day FD, 2x/day FD + 1x/day FR, and 3x/day FD. The blocks were assessed for hardness and fluoride content. Three x/day FD did not differ from 2x/day + 1x/day FR, however it enhanced demineralization protection when compared to 2x/day FD. All treatments produced an increase in enamel fluoride content compared to no treatment (sound blocks) (p < 0.05), but the differences between them were not significant. The results of this study suggest that the daily use of fluoride mouthrinse combined with that of fluoride dentifrice has similar effects on enamel demineralization and fluoride content when compared to increasing the frequency of fluoride dentifrice use.
authors.affiliation: Department of Preventive and Social Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Daniela Correia Cavalcante
authors.initials: DC
authors.lastname: Souza
authors.forename: Lina Naomi
authors.initials: LN
authors.lastname: Hashizume
authors.forename: Morjana
authors.initials: M
authors.lastname: Eidelwein
authors.forename: Marisa
authors.initials: M
authors.lastname: Maltz
mesh_terms: D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000008:administration & dosage*; D018592:Cross-Over Studies; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects*; D003802:Dentifrices / Q000008:administration & dosage*; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006245:Hardness Tests; D006801:Humans; D009067:Mouthwashes / Q000008:administration & dosage*; D016037:Single-Blind Method; D013499:Surface Properties; D013997:Time Factors; D017001:Tooth Demineralization / Q000209:etiology; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D005460:Fluorides, Topical; D009067:Mouthwashes