title: [Changes of the brain NSE, S100 and effect of ligustrazine in rats of chronic hypoxia and hypercapnia].
abstract: OBJECTIVE
  To investigate the changes of the brain NSE, S100 and ultrastructure and effect of ligustrazine in rats of chronic hypoxia and hypercapnia.
  
  
  METHODS
  Thirty rats were randomly divided into three groups: control group (A), hypoxia hypercapnia group (B), hypoxia hypercapnia added ligustrazine group (C). The brain NSE, S100 and ultrastructure were observed in rats using the technique of immunohistochemistry and electronic microscope.
  
  
  RESULTS
  (1) The mPAP was significantly higher in rats of group B than that of group A and it was much lower in rats of group C than that of group B. Differences of mCAP were not significant in three groups. (2) Serum NO of group B was significantly lower than that of group A, Serum NO of group C was higher than that of group B. (3) Immunohistochemistry showed the average value of integral light density (LD) of NSE and S100 was significantly much lower in rats of group B than that of group A and it was higher in rats of group C than that of group B. (4) The neuron and astrocyte of group B showed vacuolar degeneration and the myelin sheath showed separate. Damage of neuron is alleviated in rats of group C.
  
  
  CONCLUSIONS
  The hypoxia hypercapnia could induce damage of neuron and astrocyte in rats. The ligustrazine may be useful in protecting against hypoxia hypercapnia brain damage.
authors.affiliation: Department of Pathology, Wenzhou Medical College, Wenzhou 325003, China.
authors.forename: Lin-Sheng
authors.initials: LS
authors.lastname: Yu
authors.forename: Liang-Xing
authors.initials: LX
authors.lastname: Wang
authors.forename: Zheng-Jie
authors.initials: ZJ
authors.lastname: Xu
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D006935:Hypercapnia / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D009418:S100 Proteins / Q000378:metabolism*
chemical_list: D011719:Pyrazines; D009418:S100 Proteins; D009569:Nitric Oxide; C017953:tetramethylpyrazine