title: Elevated renin levels in patients with liver cirrhosis and hepatocellular carcinoma.
abstract: Liver fibrosis is the common consequence of chronic liver injury of any etiology, disrupting the normal architecture,and causing hepatocellular dysfunction and portal hypertension. Since the renin-angiotensin system (RAS) may be involved in chronic liver diseases, in the present study we assayed renin levels using ELISA in groups of Egyptian patients with liver cirrhosis (N=32) and hepatocellular carcinoma (HCC) (N=67), for comparison with twenty five healthy controls. The results showed significant differences between the control and liver cirrhosis patients (P<0.001) and also the controls and HCC patients (P<0.001), without significant variation between the patient groups. Furthermore, in HCC patients, it was found that the renin levels negatively correlated with serum albumin and prothrombin time (P=0.003 for each) and positively with α-fetoprotein (P=0.04). Thus, it is concluded that renin levels are elevated in patients with liver cirrhosis and HCC and suitable medical intervention should be placed for management of such alteration. Moreover, further studies are warranted to explore its prognostic significance.
authors.affiliation: Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Minufiya University, Sadat City, Minufiya, Egypt. dr_mahmoudlotfy@yahoo.co.uk
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Lotfy
authors.forename: Ayman El-Meghawry
authors.initials: Ael-M
authors.lastname: El-Kenawy
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Abdel-Aziz
authors.forename: Ibrahim
authors.initials: I
authors.lastname: El-Kady
authors.forename: Ayman
authors.initials: A
authors.lastname: Talaat
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000209:etiology; D008113:Liver Neoplasms / Q000097:blood* / Q000150:complications; D011516:Prothrombin / Q000032:analysis; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System; D012709:Serum Albumin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D012709:Serum Albumin; D000509:alpha-Fetoproteins; D011516:Prothrombin; D012083:Renin