title: [Respiratory and uro-genital infection with bacillus of Calmette-Guerin following administration as a local adjuvant therapy of bladder carcinoma].
abstract: An exemplary case report of dual-site, respiratory and genito-urinary granulomatous infection caused by bacillus of Calmette-Guerin (BCG) in a patient with prior pulmonary tuberculosis and with chronic obstructive pulmonary disease (COPD), treated for several weeks with local, intravesical adjuvant BCG therapy for a relapsing transitional bladder carcinoma, is presented and discussed in the context of the cumbersome diagnostic and differential diagnostic process, as well as recent findings in the literature. Only four cases of respiratory BCG-itis (tuberculosis-like forms) have been reported until now to the best of our knowledge (two of them following bladder instillation of BCG), but our case is the only one which showed a dual, concurrent granulomatous localization of BCG-itis, also involving the genito-urinary tract.
authors.affiliation: Dipartimento di Medicina Interna, dell'invecchiamento, e Malattie Nefrologiche, Alma Mater Studiorum Universita di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Dentale
authors.forename: Roberto
authors.initials: R
authors.lastname: Manfredi
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000283:Administration, Intravesical; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000139:chemically induced*; D014401:Tuberculosis, Urogenital / Q000139:chemically induced*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine