title: 3D Multi-spectral Image-guided Near-infrared Spectroscopy using Boundary Element Method.
abstract: Image guided (IG) Near-Infrared spectroscopy (NIRS) has the ability to provide high-resolution metabolic and vascular characterization of tissue, with clinical applications in diagnosis of breast cancer. This method is specific to multimodality imaging where tissue boundaries obtained from alternate modalities such as MRI/CT, are used for NIRS recovery. IG-NIRS is severely limited in 3D by challenges such as volumetric meshing of arbitrary anatomical shapes and computational burden encountered by existing models which use finite element method (FEM). We present an efficient and feasible alternative to FEM using boundary element method (BEM). The main advantage is the use of surface discretization which is reliable and more easily generated than volume grids in 3D and enables automation for large number of clinical data-sets. The BEM has been implemented for the diffusion equation to model light propagation in tissue. Image reconstruction based on BEM has been tested in a multi-threading environment using four processors which provides 60% improvement in computational time compared to a single processor. Spectral priors have been implemented in this framework and applied to a three-region problem with mean error of 6% in recovery of NIRS parameters.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH-03755.
authors.forename: Subhadra
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen