title: Association of RANBP1 haplotype with smooth pursuit eye movement abnormality.
abstract: Schizophrenia is a multifactorial disorder and smooth pursuit eye movement (SPEM) disturbance is proposed as one of the most consistent neurophysiological endophenotype in schizophrenia. The aim of this study was to examine the genetic association of RANBP1 polymorphisms with the risk of schizophrenia and with the risk of SPEM abnormality in schizophrenia patients in a Korean population. Two SNPs of RANBP1 were genotyped by TaqMan assay. Their genetic effect of single/haplotype polymorphisms on the risk of schizophrenia and SPEM abnormality from 354 patients and 396 controls were performed using χ² and multiple regression analyses. Although no RANBP1 polymorphisms were associated with the risk of schizophrenia, a common haplotype, RANBP1-ht2 (rs2238798G-rs175162T), showed significant association with the risk of SPEM abnormality among schizophrenia patients after multiple correction (P(corr)  = 0.002-0.0003). The results of present study provide the evidence that RANBP1 on 22q11.21 locus might be causally related to the SPEM abnormality rather than the development of schizophrenia.
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea.
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Eun Mi
authors.initials: EM
authors.lastname: Kim
authors.forename: Chul Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Jin-Wook
authors.initials: JW
authors.lastname: Sohn
authors.forename: Bong-Jo
authors.initials: BJ
authors.lastname: Kim
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Ki-Hoon
authors.initials: KH
authors.lastname: Kim
authors.forename: Tae-Min
authors.initials: TM
authors.lastname: Shin
authors.forename: Ihn-Geun
authors.initials: IG
authors.lastname: Choi
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Han
authors.forename: Jaeuk
authors.initials: J
authors.lastname: Hwang
authors.forename: InSong
authors.initials: I
authors.lastname: Koh
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Woo
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D011698:Pursuit, Smooth / Q000235:genetics*; D012044:Regression Analysis; D056910:Republic of Korea; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications / Q000235:genetics; D055815:Young Adult
chemical_list: D009687:Nuclear Proteins; C091775:ran-binding protein 1