title: Platelet adhesion to collagen.
abstract: Platelets play a central role in maintaining hemostasis mainly by binding to subendothelial collagen exposed upon vascular injury, thereby initiating thrombus formation. Platelets can bind directly to the exposed collagen through two major receptors i.e. the integrin a2b1 and glycoprotein (GP) VI. However, under high shear conditions the GPIb-V-IX receptor complex and its main ligand von Willebrand Factor are additionally needed for firm platelet adhesion to the vessel wall. In this review, we summarize the current knowledge on the individual roles and structure-function relationships of these main platelet adhesion receptors.
authors.affiliation: Laboratory for Thrombosis Research, KU Leuven campus Kortrijk, Belgium.
authors.forename: Benedicte P
authors.initials: BP
authors.lastname: Nuyttens
authors.forename: Tim
authors.initials: T
authors.lastname: Thijs
authors.forename: Hans
authors.initials: H
authors.lastname: Deckmyn
authors.forename: Katleen
authors.initials: K
authors.lastname: Broos
mesh_terms: D003094:Collagen / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D038982:Integrin alpha2beta1 / Q000737:chemistry / Q000502:physiology; D008958:Models, Molecular; D010973:Platelet Adhesiveness / Q000502:physiology*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000737:chemistry / Q000502:physiology; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology; D017434:Protein Structure, Tertiary; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D014841:von Willebrand Factor / Q000737:chemistry / Q000502:physiology
chemical_list: D038982:Integrin alpha2beta1; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; C098341:platelet membrane glycoprotein VI; D014841:von Willebrand Factor; D003094:Collagen