title: (11aS)-8-Hydr-oxy-7-meth-oxy-2,3,5,10,11,11a-hexa-hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione.
abstract: The title chiral compound, C(13)H(14)N(2)O(4), was prepared by an intra-cyclization reaction of methyl (S)-1-(4-hydr-oxy-5-meth-oxy-2-nitro-benz-yl)-5-oxopyrrolidine-2-carboxyl-ate in the presence of ethanol and iron. The five-membered substituted pyrrole ring adopts an approximate envelope conformation, while the seven-membered substituted diazepine ring displays a twist-boat conformation. Inter-molecular O-H⋯O and N-H⋯O hydrogen bonding helps to stabilize the crystal structure.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Mail Box 40, 103 Wenhua Road, Shenhe District, Shenyang 110016, People's Republic of China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhao
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.forename: Yu
authors.initials: Y
authors.lastname: Sha
authors.forename: Jing-Hong
authors.initials: JH
authors.lastname: Liu
authors.forename: Mao-Sheng
authors.initials: MS
authors.lastname: Cheng