title: Evaluation of bone ingrowth into porous titanium implant: histomorphometric analysis in rabbits.
abstract: A porous material for bone ingrowth with adequate pore structure and appropriate mechanical properties has long been sought as the ideal bone-implant interface. This study aimed to assess in vivo the influence of three types of porous titanium implant on the new bone ingrowth. The implants were produced by means of a powder metallurgy technique with different porosities and pore sizes: Group 1 = 30 % and 180 µm; Group 2 = 30% and 300 µm; and Group 3 = 40% and 180 µm;. Six rabbits received one implant of each type in the right and left tibiae and were sacrificed 8 weeks after surgery for histological and histomorphometric analyses. Histological analysis confirmed new bone in contact with the implant, formed in direction of pores. Histomorphometric evaluation demonstrated that the new bone formation was statistically significantly lower in the group G1 than in group G3, (P = 0.023). Based on these results, increased porosity and pore size were concluded to have a positive effect on the amount of bone ingrowth.
authors.affiliation: Department of Oral Biosciences and Diagnosis, Univ Estadual Paulista, São José dos Campos, SP, Brazil. luanamrv@gmail.com
authors.forename: Luana Marotta Reis de
authors.initials: LM
authors.lastname: Vasconcellos
authors.forename: Daniel Oliveira
authors.initials: DO
authors.lastname: Leite
authors.forename: Fernanda Nascimento de
authors.initials: FN
authors.lastname: Oliveira
authors.forename: Yasmin Rodarte
authors.initials: YR
authors.lastname: Carvalho
authors.forename: Carlos Alberto Alves
authors.initials: CA
authors.lastname: Cairo
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D020007:Implants, Experimental; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D010316:Particle Size; D016062:Porosity; D011208:Powders; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; D011208:Powders; D014025:Titanium