title: Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy.
abstract: Fifty-six serum posaconazole trough levels were measured in 17 cardiothoracic transplant recipients. Initial levels were ≤ 0.5, 0.51 to 0.99, and ≥ 1 μg/ml for 47, 29, and 24% of patients, respectively. Median trough levels associated with therapeutic success were higher than those associated with failure (1.55 versus 0.34 μg/ml; P = 0.006). Patients with levels consistently >0.5 μg/ml were more likely to have successful outcome (P = 0.055). Age ≥ 65 years, oral administration, and absence of proton pump inhibitors were associated with higher levels of posaconazole (P = 0.006, 0.006, and 0.001, respectively).
authors.affiliation: Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Ryan K
authors.initials: RK
authors.lastname: Shields
authors.forename: Cornelius J
authors.initials: CJ
authors.lastname: Clancy
authors.forename: Aniket
authors.initials: A
authors.lastname: Vadnerkar
authors.forename: Eun J
authors.initials: EJ
authors.lastname: Kwak
authors.forename: Fernanda P
authors.initials: FP
authors.lastname: Silveira
authors.forename: Rima C Abdel
authors.initials: RC
authors.lastname: Massih
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Pilewski
authors.forename: Maria
authors.initials: M
authors.lastname: Crespo
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Jay K
authors.initials: JK
authors.lastname: Bhama
authors.forename: Christian
authors.initials: C
authors.lastname: Bermudez
authors.forename: M Hong
authors.initials: MH
authors.lastname: Nguyen
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D014230:Triazoles / Q000097:blood* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole