title: Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system.
abstract: The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the hepatobiliary system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
authors.affiliation: Global Pathology Support, The Hague, The Netherlands. bob.thoolen@gpstoxpath.com
authors.forename: Bob
authors.initials: B
authors.lastname: Thoolen
authors.forename: Robert R
authors.initials: RR
authors.lastname: Maronpot
authors.forename: Takanori
authors.initials: T
authors.lastname: Harada
authors.forename: Abraham
authors.initials: A
authors.lastname: Nyska
authors.forename: Colin
authors.initials: C
authors.lastname: Rousseaux
authors.forename: Thomas
authors.initials: T
authors.lastname: Nolte
authors.forename: David E
authors.initials: DE
authors.lastname: Malarkey
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kaufmann
authors.forename: Karin
authors.initials: K
authors.lastname: Küttler
authors.forename: Ulrich
authors.initials: U
authors.lastname: Deschl
authors.forename: Dai
authors.initials: D
authors.lastname: Nakae
authors.forename: Richard
authors.initials: R
authors.lastname: Gregson
authors.forename: Michael P
authors.initials: MP
authors.lastname: Vinlove
authors.forename: Amy E
authors.initials: AE
authors.lastname: Brix
authors.forename: Bhanu
authors.initials: B
authors.lastname: Singh
authors.forename: Fiorella
authors.initials: F
authors.lastname: Belpoggi
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Ward
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001660:Biliary Tract Diseases / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*; D005060:Europe; D007390:International Agencies; D007564:Japan; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000145:classification / Q000175:diagnosis* / Q000473:pathology*; D051379:Mice; D009656:North America; D051381:Rats; D012376:Rodent Diseases / Q000145:classification / Q000473:pathology; D009626:Terminology as Topic; D018675:Toxicity Tests; D006113:United Kingdom