title: Reversible electrocardiogram changes and cardiomyopathy secondary to baclofen withdrawal syndrome.
abstract: Baclofen withdrawal syndrome is a rare and potentially life-threatening condition manifesting with autonomic dysreflexia, high fevers, spasticity, seizures, and multiorgan failure. Reversible cardiomyopathy due to this condition is extremely rare. A high level of suspicion is needed to recognize this condition and start an early intervention to improve patient outcome. Electrocardiographic ST-segment elevation in lead aVR was previously described in association with left main, left anterior descending, and triple-vessel coronary artery disease as well as Takotsubo cardiomyopathy. In this article we present a rare case of reversible cardiomyopathy due to baclofen withdrawal syndrome associated with diffuse ST-segment depressions and ST-segment elevation in lead aVR.
authors.affiliation: State University of New York at Buffalo, NY, USA. dimonk5@yahoo.com
authors.forename: Dmitriy
authors.initials: D
authors.lastname: Kireyev
authors.forename: Kian-Keong
authors.initials: KK
authors.lastname: Poh
mesh_terms: D000328:Adult; D020211:Autonomic Dysreflexia; D001418:Baclofen / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D002037:Bundle-Branch Block / Q000139:chemically induced; D004562:Electrocardiography / Q000295:instrumentation* / Q000379:methods; D005334:Fever; D058786:GABA-B Receptor Agonists / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D009128:Muscle Spasticity / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome; D013577:Syndrome; D013616:Tachycardia, Sinus / Q000139:chemically induced; D054549:Takotsubo Cardiomyopathy / Q000139:chemically induced*
chemical_list: D058786:GABA-B Receptor Agonists; D009125:Muscle Relaxants, Central; D001418:Baclofen