title: Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.
abstract: The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin. Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws. The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.
authors.affiliation: Department of Anesthesia, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Chen
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Huang
authors.forename: Ailun
authors.initials: A
authors.lastname: Luo
authors.forename: Pingping
authors.initials: P
authors.lastname: Zuo
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.forename: Wenyu
authors.initials: W
authors.lastname: Hao
mesh_terms: D000588:Amines / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003509:Cyclohexanecarboxylic Acids / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D004745:Enkephalins / Q000235:genetics / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D000077206:Gabapentin; D006930:Hyperalgesia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010147:Pain Measurement; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D004745:Enkephalins; D018691:Excitatory Amino Acid Antagonists; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin