title: Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer.
abstract: We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan. yoshito@sat.t.u-tokyo.ac.jp
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Hirata
authors.forename: Mario
authors.initials: M
authors.lastname: di Bernardo
authors.forename: Nicholas
authors.initials: N
authors.lastname: Bruchovsky
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Aihara
mesh_terms: D000728:Androgens / Q000008:administration & dosage* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*
chemical_list: D000728:Androgens