title: Amphibians as research models for regenerative medicine.
abstract: The ability to regenerate bone across a critical size defect would be a marked clinical advance over current methods for dealing with such structural gaps. Here, we briefly review the development of limb bones and the mandible, the regeneration of urodele limbs after amputation, and present evidence that urodele and anuran amphibians represent a valuable research model for the study of segment defect regeneration in both limb bones and mandible.
authors.affiliation: Department of Oral Pathology, Indiana University School of Dentistry, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Song
authors.forename: Bingbing
authors.initials: B
authors.lastname: Li
authors.forename: David L
authors.initials: DL
authors.lastname: Stocum
mesh_terms: D000663:Amphibians; D000818:Animals; D001861:Bone Regeneration; D023421:Models, Animal; D044968:Regenerative Medicine; D023822:Tissue Engineering