title: Respiratory muscle dysfunction in COPD: from muscles to cell.
abstract: Respiratory muscle dysfunction is a cardinal feature of acute and chronic respiratory failure in COPD. Diaphragm and accessory inspiratory muscles face increased load due to increased lung resistance and elastance, as well as increased ventilatory demands. Concomitantly, the capacity of the inspiratory muscles to generate pressure is decreased due to mechanical disadvantage imposed by hyperinflation. Additionally, inflammation and oxidative stress impair muscle fiber specific force generation and increase diaphragm susceptibility to sarcomer disruption during acute inspiratory loading. In response to this increased load diaphragm presents unique adaptations in its cellular structure and passive and contractile mechanical properties, and displays a more efficient metabolic armamentarium. A shift of muscle fiber type towards slow-twitch, oxidative type I fibers, which are more fatigue-resistant, increases diaphragmatic endurance but protein degradation and a significant reduction in myosin content decrease its force generating capacity. Furthermore, diaphragm adapts to chronic hyperinflation by sarcomere deletion so that its overall length is shortened, in an attempt to preserve optimum force-length relationship. Adaptation however may not be complete, or may be overwhelmed by pathophysiologic derangements during exercise or acute exacerbations, leading to obvious "dysfunction" of the respiratory muscles, and if sustained, ultimately to muscle fatigue and respiratory pump failure.
authors.affiliation: Department of Intensive Care Medicine, University Hospital of Heraklio, Crete, Greece. klimary@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Klimathianaki
authors.forename: K
authors.initials: K
authors.lastname: Vaporidi
authors.forename: D
authors.initials: D
authors.lastname: Georgopoulos
mesh_terms: D000818:Animals; D003964:Diaphragm / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D018763:Muscle Fatigue; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000503:physiopathology*