title: A unique paradoxical reaction to tuberculosis therapy: case report and brief review of the literature.
abstract: Extensive experience in the diagnosis and treatment of tuberculosis (TB) has led to treatment guidelines, which almost always result in progressive clinical improvement and cure in the compliant patient. Failure of a patient to respond as expected raises concerns of unexpected drug resistance, poor absorption, drug fever, or rarely an intense inflammatory reaction known as paradoxical reaction. Paradoxical reactions to anti-TB treatment are relatively rare in nonimmunocompromised individuals. Hepatic abscess is a very rare consequence of primary TB infection but has never been described as occurring as part of a paradoxical reaction. We present a case of a unique paradoxical reaction to initiation of TB treatment.
authors.affiliation: 1Department of Cardiology, University of Alabama at Birmingham, Birmingham, AL; and 2Department of Medicine, Hematology/Oncology Section, West Virginia University, Morgantown, WV.
authors.forename: Balwinder
authors.initials: B
authors.lastname: Singh
authors.forename: Fahad M
authors.initials: FM
authors.lastname: Iqbal
authors.forename: K Kiran
authors.initials: KK
authors.lastname: Sunkavalli
authors.forename: Bobby
authors.initials: B
authors.lastname: Chawla
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008100:Liver Abscess / Q000209:etiology*; D008297:Male; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents