title: Association of the 8473T>C cyclooxygenase-2 (COX-2) gene polymorphism with lung cancer risk in Asians.
abstract: OBJECTIVE
  To evaluate the impact of the COX-2 gene 8473T>C polymorphism on lung cancer risk in Asians, we conducted a comprehensive meta-analysis.
  
  
  METHODS
  A literature search was performed using PubMed and other databases before June 2010. We pooled studies according to the variants of 8473T>C and performed separate analyses according to ethnicity, histological type and smoking status, with attention to study quality and publication bias.
  
  
  RESULTS
  A total of five case-control studies including 2,450 cases and 4,302 controls were available. Overall, individuals with the C allele had a reduced lung cancer risk compared with the TT genotype on global analysis (odds ratio [OR] =0.89, 95% confidence interval [CI] =0.81 to 0.97, P=0.01, I2 for heterogeneity =0%). Significant associations were also observed in subgroups of Asian populations (OR=0.84, 95% CI=0.72 to 0.98) when stratified by ethnicity, as well as for small cell lung cancer (OR=0.54, 95% CI=0.31 to 0.95) stratified by pathological type.
  
  
  CONCLUSIONS
  Our results suggest the COX-2 gene is a factor for suffering from lung cancer, especially of small cell type among Asians.
authors.affiliation: School of Public Health and Family Medicine, Capital Medical University, Beijing, China. liufen05@ccmu.edu.cn
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Peng
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xinghua
authors.initials: X
authors.lastname: Yang
mesh_terms: D001208:Asia / Q000453:epidemiology; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D016206:Databases, Bibliographic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human