title: [Preparation and characterization of non-ionic surfactant vesicle of cantharidin].
abstract: OBJECTIVE
  To study the preparation of cantharidin entrapped non-ionic surfactant vesicle (noisome)and evaluate its quality.
  
  
  METHODS
  The niosome loaded with cantharidin was prepared using injection method by non-ionic surfactants as the carrier. An centrifugation separation method and HPLC analysis method of the cantharidin were established to detect the entrapment efficiency. The optimum preparation technology was established by a orthogonal experiment. The morphology, and particle size were studied to evaluate the preparation.
  
  
  RESULTS
  The average size of niosomes were (209. 8 +/- 0.5) nm. The entrapment efficiency of the CTD-NS was (27.5% +/- 2.0%) and Zeta potential was (41.5 +/- 0.65) mV.
  
  
  CONCLUSIONS
  The preparation of cantharidin noisome by TweenA and SpanB is practicable and successful. These experiments can be the basement of developing targeting drug delivery system.
authors.affiliation: Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Qingying
authors.initials: Q
authors.lastname: Fang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Zang
authors.forename: Baoxian
authors.initials: B
authors.lastname: Zhang
authors.forename: Qixia
authors.initials: Q
authors.lastname: Nie
authors.forename: Guohua
authors.initials: G
authors.lastname: Wang
mesh_terms: D002193:Cantharidin / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D008081:Liposomes / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D013501:Surface-Active Agents / Q000008:administration & dosage*
chemical_list: D008081:Liposomes; D013501:Surface-Active Agents; D002193:Cantharidin