title: Porokeratosis of Mibelli: Successful treatment with 5 percent topical imiquimod and topical 5 percent 5-fluorouracil.
abstract: Porokeratosis of Mibelli (PM) is a clonal disorder of keratinization. It clinically presents with one or more annular plaques with central atrophy and elevated keratotic borders. With a 7.5 percent risk of malignancy, PM should be treated to prevent transformation into squamous cell carcinoma, Bowen disease, or basal cell carcinoma. Multiple treatment options are available, however, there is not one universally effective treatment. We describe the successful treatment of porokeratosis of Mibelli of the left calf in an 83-year-old man with topical 5 percent imiquimod and topical 5 percent 5-fluorouracil.
authors.affiliation: Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Venkatarajan
authors.forename: Todd M
authors.initials: TM
authors.lastname: LeLeux
authors.forename: Deborah
authors.initials: D
authors.lastname: Yang
authors.forename: Theodore
authors.initials: T
authors.lastname: Rosen
authors.forename: Ida
authors.initials: I
authors.lastname: Orengo
mesh_terms: D000279:Administration, Cutaneous; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000963:Antimetabolites / Q000008:administration & dosage / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000150:complications; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D000077271:Imiquimod; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D007866:Leg; D008297:Male; D017499:Porokeratosis / Q000150:complications / Q000188:drug therapy*; D011230:Precancerous Conditions / Q000188:drug therapy*; D012074:Remission Induction; D012878:Skin Neoplasms / Q000150:complications / Q000517:prevention & control
chemical_list: D000634:Aminoquinolines; D000963:Antimetabolites; D007155:Immunologic Factors; D000077271:Imiquimod; D005472:Fluorouracil