title: Programming of the renin response to haemorrhage by mild maternal renal impairment in sheep.
abstract: 1. The aim of the present study was to test the hypothesis that the renin response to mechanisms activated by haemorrhage is programmed by exposure to maternal renal dysfunction. 2. In 26-27-day-old lambs born to ewes that had reduced renal function (STNxL, n=10) and lambs born to ewes with normal renal function (ConL, n=6), 1.6 mL/kg per min of blood was removed over 10 min. 3. Under basal conditions, the STNxL group had increased mean arterial pressure (P < 0.05). In response to haemorrhage, mean arterial pressure decreased in the STNxL group (P < 0.001), but there was no significant change in the ConL group. 4. Although plasma renin level increased in both groups (P < 0.05), the peak response was reduced and delayed in the STNxL group. In contrast, the rise in arginine vasopressin (AVP) level was similar in both groups and occurred over the same time course. At 24 h, both plasma renin and AVP level were the same as those measured before haemorrhage in both groups. Kidney renin level was similar in the two groups. 5. The attenuated renin response to haemorrhage in the STNxL group might explain the inability to maintain arterial pressure after haemorrhage. The results of the present study suggest that the renin response of the postnatal kidney to reductions in blood volume can be affected by the intrauterine environment. If these changes persist into adulthood, it suggests that permanent programming has occurred. Thus, the ability of an individual to respond to acute severe reductions in blood volume might be determined during intrauterine life.
authors.affiliation: Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia. a.brandon@garvan.org.au
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Brandon
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Boyce
authors.forename: Eugenie R
authors.initials: ER
authors.lastname: Lumbers
authors.forename: Vasumathy
authors.initials: V
authors.lastname: Kumarasamy
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Gibson
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure; D001810:Blood Volume; D001835:Body Weight; D005260:Female; D006339:Heart Rate; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology*; D008297:Male; D009392:Nephrectomy; D009929:Organ Size; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D011297:Prenatal Exposure Delayed Effects; D051437:Renal Insufficiency / Q000503:physiopathology*; D012083:Renin / Q000097:blood* / Q000378:metabolism; D012756:Sheep
chemical_list: D001127:Arginine Vasopressin; D012083:Renin