title: [Kaposi's sarcoma].
abstract: Kaposi's sarcoma (KS) is an unusual form of tumor which in the era of HIV/AIDS pandemic is increasingly observed outside the original endemic areas. It was shown that the development of KS is in directly related to infection with human herpes virus 8 (HHV-8). The pathophysiology of KS is complex and is influenced by HIV co-infection and by global cytokine interactions. Skin, gastrointestinal tract and respiratory organs are typically involved. A good therapeutic effect of combined antiretroviral therapy (cART) was documented. We provode a review of the current knowledge of the pathophysiology of and therapeutic options for KS and one clinical case.
authors.affiliation: Klinika Infekcních Chorob FN a LF MU Brno. pavel.polak@fnbrno.cz
authors.forename: Pavel
authors.initials: P
authors.lastname: Polák
authors.forename: Svatava
authors.initials: S
authors.lastname: Snopková
authors.forename: Petr
authors.initials: P
authors.lastname: Husa
authors.forename: Kateřina
authors.initials: K
authors.lastname: Povolná
authors.forename: Sárka
authors.initials: S
authors.lastname: Bohatá
authors.forename: Mojmír
authors.initials: M
authors.lastname: Moulis
mesh_terms: D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000150:complications / Q000175:diagnosis / Q000628:therapy / Q000821:virology