title: Roles of ADF/cofilin in actin polymerization and beyond.
abstract: In collaboration or competition with many other actin-binding proteins, the actin-depolymerizing factor/cofilins integrate transmembrane signals to coordinate the spatial and temporal organization of actin filament assembly/disassembly (dynamics). In addition, newly discovered effects of these proteins in lipid metabolism, gene regulation, and apoptosis suggest that their roles go well beyond regulating the cytoskeleton.
authors.affiliation: Department of Biochemistry and Molecular Biology, 1870 Campus Delivery, Colorado State University Fort Collins, CO 80523-1870 USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Bamburg
authors.forename: Barbara W
authors.initials: BW
authors.lastname: Bernstein