title: Gestational diabetes or lesser degrees of glucose intolerance and risk of preeclampsia.
abstract: OBJECTIVE
  We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia.
  
  
  METHODS
  A retrospective cohort study was performed among 26,105 women.
  
  
  RESULTS
  Preeclampsia was associated with the upper OGCT quartiles [114-132 mg/dL: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.09-1.44; >132 mg/dL: OR = 1.40, 95% CI 1.21-1.61] compared with <98 mg/dL adjusting for age, primigravidity, and gestational diabetes, and also to one abnormal OGTT value (adjusted OR 1.38, 95% CI 1.09-1.75) or gestational diabetes (adjusted OR 1.45, 95% CI 1.15-1.83).
  
  
  CONCLUSIONS
  Higher glucose levels are associated with preeclampsia suggesting a pathophysiological role for glucose metabolism.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 98195, USA. darcarr@u.washington.edu
authors.forename: Darcy B
authors.initials: DB
authors.lastname: Carr
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Newton
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Utzschneider
authors.forename: Mirjam V
authors.initials: MV
authors.lastname: Faulenbach
authors.forename: Steven E
authors.initials: SE
authors.lastname: Kahn
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Easterling
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
mesh_terms: D000328:Adult; D001786:Blood Glucose; D016640:Diabetes, Gestational / Q000175:diagnosis*; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis*; D005951:Glucose Tolerance Test; D006801:Humans; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D012189:Retrospective Studies; D012306:Risk
chemical_list: D001786:Blood Glucose