title: A case of regression of atypical dense deposit disease without C3 deposition in a child.
abstract: Dense deposit disease (DDD) is a rare disorder characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidneys. The diagnosis is made in most patients between 5 and 15 years of age, and within 10 years, approximately half of the affected patients progress to end-stage renal disease. We report a rare case of regressive DDD without C3 deposition after steroid therapy in an 11-year-old boy. The patient presented with edema, gross hematuria, and nephrotic-range proteinuria. Laboratory testing revealed a serum creatinine level of 1.17 mg/dL, albumin level of 2.3 g/dL, and serum C3 level of 125 mg/dL (range 90-180 mg/dL). The results of the renal biopsy were consistent with DDD without C3 deposition. After 6 weeks of steroid therapy, the nephrotic syndrome completely resolved. The follow-up renal biopsy showed a significant reduction in mesangial proliferation and disappearance of electron-dense deposits in the GBM.
authors.affiliation: Department of Pediatrics and Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Pyoung Han
authors.initials: PH
authors.lastname: Hwang
authors.forename: Mung Jae
authors.initials: MJ
authors.lastname: Kang
authors.forename: Dae-Yeol
authors.initials: DY
authors.lastname: Lee