title: Eosinophil cationic protein and clinical outcome after bare metal stent implantation.
abstract: OBJECTIVE
  we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation.
  
  
  METHODS
  basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoing BMS implantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up.
  
  
  RESULTS
  eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8-47.3) vs. 9.5 (5.0-27.2) g/L, p=0.02]. At follow-up, ECP level>11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1-10.4, p=0.03).
  
  
  CONCLUSIONS
  basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.
authors.affiliation: Institute of Cardiology, Department of Internal Medicine and Allergology, Catholic University of the Sacred Heart, Rome, Italy. gniccoli73@hotmail.it
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Niccoli
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Sgueglia
authors.forename: Micaela
authors.initials: M
authors.lastname: Conte
authors.forename: Nicola
authors.initials: N
authors.lastname: Cosentino
authors.forename: Silvia
authors.initials: S
authors.lastname: Minelli
authors.forename: Flavia
authors.initials: F
authors.lastname: Belloni
authors.forename: Carlo
authors.initials: C
authors.lastname: Trani
authors.forename: Vito
authors.initials: V
authors.lastname: Sabato
authors.forename: Francesco
authors.initials: F
authors.lastname: Burzotta
authors.forename: Italo
authors.initials: I
authors.lastname: Porto
authors.forename: Antonio Maria
authors.initials: AM
authors.lastname: Leone
authors.forename: Domenico
authors.initials: D
authors.lastname: Schiavino
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
mesh_terms: D000368:Aged; D047150:Eosinophil Cationic Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D047150:Eosinophil Cationic Protein