title: The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium.
abstract: Mammalian spermatogenesis, a complex process that involves the movement of developing germ cells across the seminiferous epithelium, entails extensive restructuring of Sertoli-Sertoli and Sertoli-germ cell junctions. Presently, it is not entirely clear how zygotene spermatocytes gain entry into the adluminal compartment of the seminiferous epithelium, which is sealed off from the systemic circulation by the Sertoli cell component of the blood-testis barrier, without compromising barrier integrity. To begin to address this question, it is critical that we first have a good understanding of the biology and the regulation of different types of Sertoli-Sertoli and Sertoli-germ cell junctions in the testis. Supported by recent studies in the field, we discuss how crosstalk between different types of junctions contributes to their restructuring during germ cell movement across the blood-testis barrier. We place special emphasis on the emerging role of desmosome-like junctions as signal transducers during germ cell movement across the seminiferous epithelium.
authors.affiliation: Population Council, Center for Biomedical Research, New York, New York, USA.
authors.forename: Pearl P Y
authors.initials: PP
authors.lastname: Lie
authors.forename: C Yan
authors.initials: CY
authors.lastname: Cheng
authors.forename: Dolores D
authors.initials: DD
authors.lastname: Mruk
mesh_terms: D022005:Adherens Junctions / Q000502:physiology*; D000818:Animals; D003896:Desmosomes / Q000502:physiology*; D005854:Germ Cells / Q000378:metabolism; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*; D008297:Male; D012670:Seminiferous Epithelium / Q000502:physiology*; D012708:Sertoli Cells / Q000378:metabolism; D015398:Signal Transduction