title: [The vasoactive material and pulmonary vascular structural remodeling in rats].
abstract: OBJECTIVE
  To investigate the role of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) on pulmonary vascular structural remodeling in rats and pika.
  
  
  METHODS
  The Wistar rats which reside at 2 260 m were carried to 3 417 m. After they were fed 24 hours,2 weeks and 3 weeks respectively, the level of VEGF and ET-1 were measured using a kit by ELISA method. Pulmonary tissue was taken out to stain with elastica-Van Gieson. The amount of pulmonary arteries (< 100 microm) and the component ratio of MA, PMA,and NMA were calculated by using a light microscope. The ratio of right ventricle weight to left ventricle plus septum weight (RV/LV + S) were measured.
  
  
  RESULTS
  The ET-1 was significantly different in pika as compared with 24 h, 2 weeks, 3 weeks hypoxic rats (P < 0.01) respectively. The levels of VEGF in 2 weeks, 3 weeks rats were much higher than that of pika but no difference was found between pika and 24 h hypoxic rats. The ratio of MA, PMA obviously increased, and NMA decreased significantly, right ventricular hypertrophy was developed in differ groups of hypoxic rats.
  
  
  CONCLUSIONS
  The VEGF and ET-1 participate the muscularization of pulmonary vessels during hypoxia and play an important role in the process of hypoxic pulmonary hypertension in rats, however the VEGF and ET-1 may be maintainable only normal organic function in pika.
authors.affiliation: Qinghai High Altitude Medical Sciences Institute, Xining 810012, China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Chen
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Wang
authors.forename: Man-Tang
authors.initials: MT
authors.lastname: Yu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006976:Hypertension, Pulmonary / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D007793:Lagomorpha; D008168:Lung / Q000098:blood supply*; D008297:Male; D011651:Pulmonary Artery / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D019332:Endothelin-1; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat