title: Modeling columnar spatiotemporal dynamics of nitric oxide as a primary controlling element of arteriole dilation during neurovascular coupling.
abstract: Although the mechanism of neurovascular coupling remains inadequately understood, physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling. This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution. Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view, which may lead the way to decoding the mechanism of neurovascular coupling.
authors.affiliation: Department of Biomedical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Minglai
authors.initials: M
authors.lastname: Wang
authors.forename: Yingle
authors.initials: Y
authors.lastname: Fan
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001160:Arterioles / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply*; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism*; D014664:Vasodilation / Q000502:physiology*
chemical_list: D009569:Nitric Oxide