title: [TGF-beta and HSP70 expression in human skin fibroblasts after ultraviolet B irradiation].
abstract: OBJECTIVE
  For further understanding the signal transduction pathway of the inducible HSP70 expression the expression of TGF-betamRNA and HSP70 in fibroblasts after 5, 10 and 20 mJ/cm2 of UVB irradiation, and the content of TGF-beta protein in culture supernatants and HSP70 expression in fibroblasts by 10mJ/cm2 UVB irradiation after preincubation with the anti-human TGF-beta receptor II antibody were observed.
  
  
  RESULTS
  (1) TGF-betamRNA expression positively correlated with HSP70 expression in UVB irradiation of different doses (r = 0. 906). (2) TGF-beta content in the culture supernatants negatively correlated with the HSP70 expression induced in adding anti-human TGF-beta receptor II antibody and UVB treatment condition (r = - 0.995).
  
  
  CONCLUSIONS
  TheTGF-beta play an important action in HSP70 inducing by UVB irradiation.
authors.affiliation: Department of Physiology, China Medical University, Liaoning Shenyang 110001, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cao
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Zhao
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
mesh_terms: D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism* / Q000528:radiation effects*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D012867:Skin / Q000166:cytology; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D018840:HSP70 Heat-Shock Proteins; D016212:Transforming Growth Factor beta