title: Protein-energy nutritional status and kidney disease-specific quality of life in hemodialysis patients.
abstract: OBJECTIVE
  Health-related quality of life (HRQOL) is an important outcome in dialysis care. Previous research has related protein-energy nutritional status to generic HRQOL domains, but it is still not clear as to how it relates to HRQOL domains that are unique to hemodialysis patients. Therefore, our aim was to study the relation between protein-energy nutritional status and kidney disease-specific HRQOL domains in hemodialysis patients.
  
  
  METHODS
  This was a cross-sectional study.
  
  
  METHODS
  This study was performed at multiple centers.
  
  
  METHODS
  We evaluated the first 590 hemodialysis patients who had enrolled in the Convective Transport Study.
  We measured protein-energy nutritional status by using the Subjective Global Assessment, albumin, normalized nitrogen appearance, creatinine, body mass index, and cholesterol.
  
  
  METHODS
  HRQOL was assessed by using the Kidney Disease Quality Of Life-Short Form.
  
  
  RESULTS
  In all, 83% of the cohort was found to be well-nourished on the basis of the Subjective Global Assessment. Multiple nutritional parameters were positively related to the physical summary of generic HRQOL and to the following kidney disease-specific HRQOL scales: the effects of the kidney disease on daily life, the burden of the kidney disease, and overall health.
  
  
  CONCLUSIONS
  This study showed that, even in predominantly well-nourished hemodialysis patients, protein-energy nutritional status was significantly related to kidney disease-specific HRQOL.
authors.affiliation: Department of Nephrology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Albert H A
authors.initials: AH
authors.lastname: Mazairac
authors.forename: G Ardine
authors.initials: GA
authors.lastname: de Wit
authors.forename: E Lars
authors.initials: EL
authors.lastname: Penne
authors.forename: Neelke C
authors.initials: NC
authors.lastname: van der Weerd
authors.forename: Muriel P C
authors.initials: MP
authors.lastname: Grooteman
authors.forename: Marinus A
authors.initials: MA
authors.lastname: van den Dorpel
authors.forename: Menso J
authors.initials: MJ
authors.lastname: Nubé
authors.forename: Erik
authors.initials: E
authors.lastname: Buskens
authors.forename: Renée
authors.initials: R
authors.lastname: Lévesque
authors.forename: Piet M
authors.initials: PM
authors.lastname: Ter Wee
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Bots
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blankestijn
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002170:Canada; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000523:psychology* / Q000628:therapy; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009426:Netherlands; D009664:Norway; D009752:Nutritional Status; D011506:Proteins / Q000378:metabolism*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis
chemical_list: D011506:Proteins; D012709:Serum Albumin; D002784:Cholesterol; D003404:Creatinine