title: [Expressions of EphB4 and HIF-1α in human lung cancer and their significances].
abstract: BACKGROUND
  It has been proved that EphB4 and HIF-1α are closely related to the oncogenesis and development of lung cancer. The aim of this study is to investigate the biological significances of EphB4 and HIF-1α in lung cancer and their relationship with each other.
  
  
  METHODS
  The expression of EphB4 and HIF-1α was detected in 54 lung cancer tissues and 10 normal lung tissues as control by immunohistochemical method.
  
  
  RESULTS
  EphB4 and HIF-1α proteins were detectable in 50.0% and 42.6% of all 54 lung cancer tissues respectively, which were significantly higher than those of the control (P < 0.05); the positive ratios and the levels of the expressions of EphB4 and HIF-1α proteins were closely related to gross types, differentiations and clinical stages (P < 0.05), but not to histological classification, age, sex and lymph node metastasis (P > 0.05). A highly positive correlation was observed between EphB4 and HIF-1α expression (P < 0.01 ).
  
  
  CONCLUSIONS
  Overexpression of EphB4 and HIF-1α may play an important role in the pathogenesis, progression and malignant degree of lung cancer. Detection of EphB4 and HIF-1α expression might be helpful to predict prognosis of patients with lung cancer.
authors.affiliation: Department of Pathology, Tianjin First Central Hospital, Tianjin 300192, P.R.China.
authors.forename: Congzhong
authors.initials: C
authors.lastname: Zhu
authors.forename: Xinyun
authors.initials: X
authors.lastname: Wang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zheng
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Cuiyun
authors.initials: C
authors.lastname: Sun
authors.forename: Aixiang
authors.initials: A
authors.lastname: Wang
authors.forename: Fengyun
authors.initials: F
authors.lastname: Zhao