title: Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice.
abstract: Clinical studies suggest that rosiglitazone (RSG) treatment may increase the incidence of heart failure in diabetic patients. In this study, we examined whether a high corn oil diet with RSG treatment in insulin resistant aging mice exerted metabolic and pro-inflammatory effects that stimulate cardiac dysfunction. We also evaluated whether fish oil attenuated these effects. Female C57BL/6J mice (13 months old) were divided into 5 groups: (1) lean control (LC), (2) corn oil, (3) fish oil, (4) corn oil+RSG and (5) fish oil+RSG. Mice fed a corn oil enriched diet and RSG developed hypertrophy of the left ventricle (LV) and decreased fractional shortening, despite a significant increase in total body lean mass. In contrast, LV hypertrophy was prevented in RSG treated mice fed a fish oil enriched diet. Importantly, hyperglycemia was controlled in both RSG groups. Further, fish oil+RSG decreased LV expression of atrial and brain natriuretic peptides, fibronectin and the pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α, concomitant with increased interleukin-10 and adiponectin levels compared to the corn oil+RSG group. Fish oil+RSG treatment suppressed inflammation, increased serum adiponectin, and improved fractional shortening, attenuating the cardiac remodeling seen in the corn oil+RSG diet fed C57BL/6J insulin resistant aging mice. Our results suggest that RSG treatment has context-dependent effects on cardiac remodeling and serves a negative cardiac role when given with a corn oil enriched diet.
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, TX 78229-3900, USA. halade@uthscsa.edu
authors.forename: Ganesh V
authors.initials: GV
authors.lastname: Halade
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Williams
authors.forename: Merry L
authors.initials: ML
authors.lastname: Lindsey
authors.forename: Gabriel
authors.initials: G
authors.lastname: Fernandes
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D003094:Collagen / Q000378:metabolism; D003314:Corn Oil / Q000276:immunology; D004032:Diet; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects; D006943:Hyperglycemia / Q000188:drug therapy; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D007333:Insulin Resistance; D051379:Mice; D008810:Mice, Inbred C57BL; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000009:adverse effects / Q000627:therapeutic use*; D014463:Ultrasonography
chemical_list: D005395:Fish Oils; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D003314:Corn Oil; D003094:Collagen