title: Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery.
abstract: OBJECTIVE
  C-reactive protein (CRP) is the most extensively studied inflammatory risk marker, and elevated serum CRP concentrations in pregnant women are known to be associated with subsequent development of preeclampsia and preterm delivery. Researchers have suggested that folate intake may help to control the inflammation process. We examined whether folate nutrition modifies the relationship between serum CRP concentration and gestational age at delivery.
  
  
  METHODS
  Serum CRP concentrations were analyzed in 815 pregnant women between 12 and 28 weeks of gestation. Dietary intakes were assessed using a 24-h dietary recall. The serum folate and high-sensitivity CRP concentrations were analyzed by radioassay and latex agglutination tests, respectively.
  
  
  RESULTS
  Serum CRP concentration was negatively correlated (P < 0.001) with gestational age at delivery. Serum folate concentration was negatively correlated (P < 0.01) with serum CRP concentration, and total dietary folate intake was positively correlated (P < 0.001) with serum folate concentration. Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 μg dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml).
  
  
  CONCLUSIONS
  We found that adequate maternal folate intake during pregnancy may have a beneficial role against shorter gestational age at delivery, which is associated with higher serum CRP concentrations in pregnant women.
authors.affiliation: Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: J-Y
authors.initials: JY
authors.lastname: Hwang
authors.forename: E-H
authors.initials: EH
authors.lastname: Ha
authors.forename: H
authors.initials: H
authors.lastname: Park
authors.forename: M
authors.initials: M
authors.lastname: Ha
authors.forename: S-J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Y-C
authors.initials: YC
authors.lastname: Hong
authors.forename: N
authors.initials: N
authors.lastname: Chang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D004034:Diet Surveys; D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second / Q000097:blood; D047928:Premature Birth / Q000097:blood / Q000517:prevention & control*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D005492:Folic Acid