title: Fibroblasts alter spiral wave stability.
abstract: We consider a three-domain model of cardiac tissue consisting of fibroblasts, myocytes, and extracellular space. We show in the one dimensional case that the fibroblasts with different resting potentials may alter restitution properties of tissue. On this basis we demonstrated that in two dimensional slice of cardiac tissue, a spiral wave break up can be caused purely by the influence of fibroblasts and, vice-versa, initially unstable spiral can be stabilized by fibroblasts depending on the value of their resting potential.
authors.affiliation: Department of Control Theory, Nizhny Novgorod University, 23, Gagarin Avenue, 603950 Nizhny Novgorod, Russia. valentin.s.petrov@gmail.com
authors.forename: Valentin S
authors.initials: VS
authors.lastname: Petrov
authors.forename: Grigory V
authors.initials: GV
authors.lastname: Osipov
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kurths
mesh_terms: D000200:Action Potentials / Q000502:physiology; D055724:Electrophysiological Phenomena; D005347:Fibroblasts / Q000502:physiology*; D006321:Heart / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000166:cytology