title: Effect of captopril on TNF-α and IL-10 in the livers of bile duct ligated rats.
abstract: BACKGROUND
  The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensin-converting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats.
  
  
  OBJECTIVE
  The present study was conducted to investigate the effects of captopril on cytokine production in hepatic fibrosis induced by a bile duct ligation model in rats.
  
  
  METHODS
  Male rats were divided into four groups including; control, sham operated, BDL, and BDL plus captopril (10 mg/kg/day, orally). After 28 days of treatment, the livers were removed for cytokine analysis. Hepatic interleukin (IL)-10 and tumor necrosis factor (TNF)-α levels were measured.
  
  
  RESULTS
  Captopril treatment decreased the hepatic content of the proinflammatory cytokine TNF-α and increased the anti-inflammatory cytokine IL-10.
  
  
  CONCLUSIONS
  the present study suggests that the protective effect of captopril on hepatic fibrosis is likely to be mediated by cytokine production.
authors.affiliation: Department of Pharmacology, School of Medicine, Ardebil University of Medical Sciences, Ardebil, Iran. k.amirshahrokhi@arums.ac.ir
authors.forename: Keyvan
authors.initials: K
authors.lastname: Amirshahrokhi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ghazi-khansari
authors.forename: Ahmad
authors.initials: A
authors.lastname: Mohammadi-Farani
authors.forename: Golnar
authors.initials: G
authors.lastname: Karimian
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001652:Bile Ducts / Q000601:surgery*; D002216:Captopril / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D016753:Interleukin-10 / Q000378:metabolism*; D008026:Ligation; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002216:Captopril