title: Synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives.
abstract: An improved synthetic protocol for a novel series of 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives has been developed using different methods of synthesis. The synthesized compounds are evaluated for their hypolipidemic and hypoglycemic activity by high fat diet induced hyperlipidemia and hyperglycemia in Sprague-Dawley rats.
authors.affiliation: Dr. Rafiq Zakaria Campus, Y.B. Chavan College of Pharmacy, Aurangabad, India. santoshmokale@rediffmail.com
authors.forename: Santosh N
authors.initials: SN
authors.lastname: Mokale
authors.forename: R D
authors.initials: RD
authors.lastname: Elgire
authors.forename: Nikhil
authors.initials: N
authors.lastname: Sakle
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects; D058607:Fibric Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D006943:Hyperglycemia / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D004041:Dietary Fats; D058607:Fibric Acids; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D011422:Propionates; D013844:Thiazoles; C010285:fibric acid; C029658:propionic acid