title: Amino acids and diabetes: implications for endocrine, metabolic and immune function.
abstract: Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes.
authors.affiliation: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute and UCD Institute for Sport and Health, UCD Dublin, Belield, Dublin 4, Ireland. philip.newsholme@ucd.ie
authors.forename: Philip
authors.initials: P
authors.lastname: Newsholme
authors.forename: Fernando
authors.initials: F
authors.lastname: Abdulkader
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rebelato
authors.forename: Talita
authors.initials: T
authors.lastname: Romanatto
authors.forename: Carlos Hermano J
authors.initials: CH
authors.lastname: Pinheiro
authors.forename: Kaio Fernando
authors.initials: KF
authors.lastname: Vitzel
authors.forename: Erica Portioli
authors.initials: EP
authors.lastname: Silva
authors.forename: Roberto B
authors.initials: RB
authors.lastname: Bazotte
authors.forename: Joaquim
authors.initials: J
authors.lastname: Procopio
authors.forename: Rui
authors.initials: R
authors.lastname: Curi
authors.forename: Renata
authors.initials: R
authors.lastname: Gorjao
authors.forename: Tania Cristina
authors.initials: TC
authors.lastname: Pithon-Curi
mesh_terms: D000596:Amino Acids / Q000378:metabolism / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D050416:Glucagon-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000503:physiopathology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D018482:Muscle, Skeletal / Q000503:physiopathology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology
chemical_list: D000596:Amino Acids; D007328:Insulin; D005947:Glucose