title: HRCT findings in the lungs of non-smokers with neurofibromatosis.
abstract: OBJECTIVE
  Interstitial lung disease in neurofibromatosis (NF) has been disputed and attributed to smoking-related changes. The aim of this study was to describe HRCT findings in the lungs of non-smokers with NF.
  
  
  METHODS
  Six never-smokers with NF underwent lung HRCT. Two radiologists evaluated the HRCT scans and a final decision was reached by consensus. The HRCT scans were analyzed with regard to the number, size, location (upper, middle or lower lung zone) and distribution (peripheral and central) of lung cysts and the presence of ground-glass density centrilobular micronodules.
  
  
  RESULTS
  All patients with NF had small (2-18 mm) thin wall cysts and upper-lobe predominant patchy areas of ground-glass density centrilobular micronodules. In five cases, there were 3-17 cysts and in one there were numerous (>100). Lung cysts were central (1), subpleural (1) and in both locations (4).
  
  
  CONCLUSIONS
  Interstitial lung disease in NF is not associated with smoking and may be entirely asymptomatic. HRCT may reveal small cysts, with barely perceptible walls therefore not representing emphysema and occasionally a minimal micronodular pattern of ground glass opacity. There was no radiologic evidence of lung fibrosis, honeycombing or severe bullous disease.
authors.affiliation: Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece. aoikonom@med.duth.gr
authors.forename: Anastasia
authors.initials: A
authors.lastname: Oikonomou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vadikolias
authors.forename: Theodosios
authors.initials: T
authors.lastname: Birbilis
authors.forename: Demosthenes
authors.initials: D
authors.lastname: Bouros
authors.forename: Panos
authors.initials: P
authors.lastname: Prassopoulos
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000000981:diagnostic imaging*; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012907:Smoking; D014057:Tomography, X-Ray Computed / Q000379:methods*