title: [Relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents in cultured hypothalamic cells].
abstract: OBJECTIVE
  To investigate the relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents.
  
  
  METHODS
  After hypoxic preconditioning and acute anoxia the I(Na), I(K) were measured in cultured hypothalamic cells by patch-clamp whole cell recording technique.
  
  
  RESULTS
  The amplification of Na+ currents did not been significantly changed, but the amplification of K+ currents was in hypoxic preconditioning neurons; acute anoxia lead to the inhibition of Na+, K+ currents in the two groups, while Na+, K+ currents in non-preconditioned control group were inhibited severity than hypoxic preconditioning group.
  
  
  CONCLUSIONS
  It is presumed enhanced anoxia tolerance induced by hypoxic preconditioning may be related to the opening of K+ channels.
authors.affiliation: Department of Neurobiology, Institute of basic Medical Sciences, Academy of Military Medical Sciences, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Ai-Shi
authors.initials: AS
authors.lastname: Ding
authors.forename: Fu-Zhuang
authors.initials: FZ
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D002478:Cells, Cultured; D007031:Hypothalamus / Q000166:cytology / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology*; D010100:Oxygen / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000502:physiology*
chemical_list: D012964:Sodium; D011188:Potassium; D010100:Oxygen