title: Surgery induced immunosuppression.
abstract: Surgery and anaesthesia result in a variety of metabolic and endocrine responses, which result in a generalised state of immunosuppression in the immediate post-operative period. Surgery induced immunosuppression has been implicated in the development of post-operative septic complications and tumour metastasis formation. In addition the effectiveness of many treatments in the adjuvant setting is dependent on a functioning immune system. By understanding the mechanisms contributing to surgery-induced immunosuppression, surgeons may undertake strategies to minimise its effect and reduce potential short-term and long-term consequences to patients.
authors.affiliation: Department of Surgery, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, United Kingdom. bvhogan@yahoo.co.uk
authors.forename: Brian V
authors.initials: BV
authors.lastname: Hogan
authors.forename: Mark B
authors.initials: MB
authors.lastname: Peter
authors.forename: Hrishikesh G
authors.initials: HG
authors.lastname: Shenoy
authors.forename: Kieran
authors.initials: K
authors.lastname: Horgan
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Hughes
mesh_terms: D006801:Humans; D007108:Immune Tolerance / Q000276:immunology / Q000502:physiology; D011184:Postoperative Period; D013312:Stress, Physiological / Q000276:immunology*; D013514:Surgical Procedures, Operative