title: No Kiss1ng by leptin during puberty?
abstract: Leptin exerts a permissive action on puberty by stimulating release of gonadotropin-releasing hormone (GnRH) in the hypothalamus. However, GnRH neurons lack leptin receptor (LepR), indicating that leptin must indirectly regulate these neurons. The Kiss1 gene produces kisspeptins that stimulate GnRH secretion. Because Kiss1 neurons express LepR and inactivation of Kiss1 causes hypogonadotropic hypogonadism, Donato et al., in this issue of the JCI, assessed whether deletion of LepR from Kiss1 neurons would prevent sexual maturation. Unexpectedly, mice lacking LepR in Kiss1 neurons had normal pubertal development and fertility. In contrast, deletion of LepR from the ventral premammillary nucleus, a region of the brain involved in sexual behavior, prevented puberty and fertility. These findings highlight the complex biology of leptin in reproduction.
authors.affiliation: Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. ahima@mail.med.upenn.edu
authors.forename: Rexford S
authors.initials: RS
authors.lastname: Ahima
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D005260:Female; D059648:Kisspeptins; D020738:Leptin / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008959:Models, Neurological; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D054411:Receptors, Leptin / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000502:physiology; D012741:Sexual Maturation / Q000235:genetics / Q000502:physiology*
chemical_list: C491407:Kiss1 protein, mouse; D059648:Kisspeptins; D020738:Leptin; D011506:Proteins; D054411:Receptors, Leptin