title: Antinociceptive effect of extract of Emilia sonchifolia in mice.
abstract: OBJECTIVE
  Emilia sonchifolia (L.) DC. (Asteraceae) is a medicinal plant traditionally used in Brazilian folk medicine to treat asthma, fever, cuts, wounds and rheumatism. This study was conducted to establish the antinociceptive properties of hydroethanolic extract from aerial parts of Emilia sonchifolia in mice using chemical and thermal models of nociception.
  
  
  METHODS
  To evaluate the antinociceptive effect of Emilia sonchifolia hydroethanolic extract (EsHE) administered by oral route, peripheral (acetic acid-induced abdominal writhing and formalin), spinal (tail flick) and supra-spinal (hot plate) behavioral models of acute pain were used. High-performance liquid chromatography (HPLC) was used to determine the fingerprint chromatogram of the EsHE.
  
  
  RESULTS
  The EsHE at test doses of 100 and 300 mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. The extract had a stronger antinociceptive effect than morphine. Administration of the opioid receptor antagonist, naloxone, completely inhibited the antinociceptive effect induced by EsHE (100mg/kg). The presence of phenolic compounds in the extract of Emilia sonchifolia was confirmed using HPLC.
  
  
  CONCLUSIONS
  The extract of Emilia sonchifolia markedly exhibits opioid-mediated anti-nociceptive activity action in mice. Thus, may be useful in the treatment of inflammatory hyperalgesic disorders, which supports previous claims of its traditional use.
authors.affiliation: Laboratory of Physiology, Institute of Biomedical Sciences, Federal University of Alfenas-MG, Brazil.
authors.forename: Verônica M
authors.initials: VM
authors.lastname: Couto
authors.forename: Fabiana C
authors.initials: FC
authors.lastname: Vilela
authors.forename: Danielle F
authors.initials: DF
authors.lastname: Dias
authors.forename: Marcelo H
authors.initials: MH
authors.lastname: Dos Santos
authors.forename: Roseli
authors.initials: R
authors.lastname: Soncini
authors.forename: Carlos Giovani O
authors.initials: CG
authors.lastname: Nascimento
authors.forename: Alexandre
authors.initials: A
authors.lastname: Giusti-Paiva
mesh_terms: D019342:Acetic Acid; D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001522:Behavior, Animal / Q000187:drug effects; D001938:Brazil; D004195:Disease Models, Animal; D005557:Formaldehyde; D006358:Hot Temperature; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010636:Phenols / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D010636:Phenols; D010936:Plant Extracts; D005557:Formaldehyde; D009270:Naloxone; D009020:Morphine; D019342:Acetic Acid