title: Future dentistry: cell therapy meets tooth and periodontal repair and regeneration.
abstract: Cell-based tissue repair of the tooth and - tooth-supporting - periodontal ligament (PDL) is a new attractive approach that complements traditional restorative or surgical techniques for replacement of injured or pathologically damaged tissues. In such therapeutic approaches, stem cells and/or progenitor cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we discuss the clonogenic potential of human dental and periodontal tissues such as the dental pulp and the PDL and their potential for tooth and periodontal repair and/or regeneration. We propose novel therapeutic approaches using stem cells or progenitor cells, which are targeted to regenerate the lost dental or periodontal tissue.
authors.affiliation: Clinical and Diagnostic Sciences, Dental Institute, King's College London, London, UK.
authors.forename: Javier
authors.initials: J
authors.lastname: Catón
authors.forename: Nagihan
authors.initials: N
authors.lastname: Bostanci
authors.forename: Eumorphia
authors.initials: E
authors.lastname: Remboutsika
authors.forename: Cosimo
authors.initials: C
authors.lastname: De Bari
authors.forename: Thimios A
authors.initials: TA
authors.lastname: Mitsiadis
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D003813:Dentistry; D006801:Humans; D010510:Periodontal Diseases / Q000473:pathology / Q000628:therapy*; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D014070:Tooth / Q000502:physiology*