title: High tibial osteotomy using polycaprolactone-tricalcium phosphate polymer wedge in a micro pig model.
abstract: Medial open-wedge high tibial osteotomy has been gaining popularity in recent years, but adequate supporting material is required in the osteotomy gap for early weight-bearing and rapid union. The purpose of this study was to investigate whether the implantation of a polycaprolactone-tricalcium phosphate composite scaffold wedge would enhance healing of the osteotomy in a micro pig model. We carried out open-wedge high tibial osteotomies in 12 micro pigs aged from 12 to 16 months. A scaffold wedge was inserted into six of the osteotomies while the other six were left open. Bone healing was evaluated after three and six months using plain radiographs, CT scans, measurement of the bone mineral density and histological examination. Complete bone union was obtained at six months in both groups. There was no collapse at the osteotomy site, loss of correction or failure of fixation in either group. Staining with haematoxylin and eosin demonstrated that there was infiltration of new bone tissue into the macropores and along the periphery of the implanted scaffold in the scaffold group. The CT scans and measurement of the bone mineral density showed that at six months specimens in the scaffold group had a higher bone mineral density than in the control group, although the implantation of the polycaprolactone-tricalcium phosphate composite scaffold wedge did not enhance healing of the osteotomy.
authors.affiliation: Department of Orthopaedic Surgery, Korea University Guro Hospital, 80 Guro-Dong, Guro-Gu, Seoul 152-703, Korea.
authors.forename: H-C
authors.initials: HC
authors.lastname: Lim
authors.forename: J-H
authors.initials: JH
authors.lastname: Bae
authors.forename: H-R
authors.initials: HR
authors.lastname: Song
authors.forename: S H
authors.initials: SH
authors.lastname: Teoh
authors.forename: H-K
authors.initials: HK
authors.lastname: Kim
authors.forename: D-H
authors.initials: DH
authors.lastname: Kum
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D002130:Calcium Phosphates; D004195:Disease Models, Animal; D010012:Osteogenesis / Q000502:physiology; D010027:Osteotomy / Q000295:instrumentation* / Q000379:methods; D011091:Polyesters; D013552:Swine; D013556:Swine, Miniature; D013977:Tibia / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D054457:Tissue Scaffolds; D014057:Tomography, X-Ray Computed; D014945:Wound Healing / Q000502:physiology
chemical_list: D002130:Calcium Phosphates; D011091:Polyesters; C016240:polycaprolactone; C018392:tricalcium phosphate