title: [N-cadherin as a receptor for adhesion and endocytosis of Aspergillus fumigatus by human umbilical vein endothelial cells].
abstract: OBJECTIVE
  To study the receptor for adhesion and endocytosis of Aspergillus fumigatus hyphae by human umbilical vein endothelial cells (HUVEC).
  
  
  METHODS
  Aspergillus fumigatus hyphae were incubated with the total protein of HUVEC for investigating the binding of N-cadherin and the fungus. After the model of adhesion and endocytosis of Aspergillus fumigatus by HUVEC was established, the capacity of adhesion and endocytosis was evaluated with the presence of the antibody to N-cadherin.
  
  
  RESULTS
  N-cadherin sticked to the surface of Aspergillus fumigatus. Adhesion and endocytosis were inhibited with the presence of the antibody to N-cadherin.
  
  
  CONCLUSIONS
  N-cadherin is a receptor for adhesion and endocytosis of Aspergillus fumigatus by HUVEC.
authors.affiliation: Department of Respiratory Medicine, the Second Military Medical University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Shi
authors.forename: Peng-Peng
authors.initials: PP
authors.lastname: Zhang
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Shen
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
mesh_terms: D001232:Aspergillus fumigatus / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D002478:Cells, Cultured; D004705:Endocytosis; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism* / Q000382:microbiology*; D006801:Humans
chemical_list: D015820:Cadherins