title: Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs.
abstract: G protein-coupled receptors (GPCRs) represent the largest class of integral membrane protein receptors in the human genome. Despite the great diversity of ligands that activate these GPCRs, they interact with a relatively small number of intracellular proteins to induce profound physiological change. Both heterotrimeric G proteins and GPCR kinases are well known for their ability to specifically recognize GPCRs in their active state. Recent structural studies now suggest that heterotrimeric G proteins and GPCR kinases identify activated receptors via a common molecular mechanism despite having completely different folds.
authors.affiliation: From the Life Sciences Institute and.
authors.forename: Chih-Chin
authors.initials: CC
authors.lastname: Huang
authors.affiliation: From the Life Sciences Institute and; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-2216. Electronic address: johntesmer@umich.edu.
authors.forename: John J G
authors.initials: JJG
authors.lastname: Tesmer
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D054768:G-Protein-Coupled Receptor Kinases / Q000737:chemistry / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D017510:Protein Folding
chemical_list: D054768:G-Protein-Coupled Receptor Kinases; D020962:Heterotrimeric GTP-Binding Proteins