title: [Expression of c-myb in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma].
abstract: OBJECTIVE
  To investigate the expression of c-myb in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma.
  
  
  METHODS
  The expression levels of c-myb in the esophageal mucosa tissue of patients with reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma were detected by real-time fluorescent quantitative RT-PCR.
  
  
  RESULTS
  The expression levels of c-myb mRNA in Barrett esophagus and esophageal adenocarcinoma tissues was significantly higher than that in normal and reflux esophagitis esophageal tissue (P<0.05 or 0.01), and increased progressively with the development of reflux esophagitis into Barrett esophagus and esophageal adenocarcinoma.
  
  
  CONCLUSIONS
  The expression level of c-myb mRNA is closely related with the development of Barrett esophagus and esophageal adenocarcinoma, and may be used as a valuable index for monitoring the early onset and intervention of Barrett esophagus and esophageal adenocarcinoma.
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, China. lovely163@163.com
authors.forename: Chun-rong
authors.initials: CR
authors.lastname: Ren
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Guo
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D004942:Esophagitis, Peptic / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D020598:Proto-Oncogene Proteins c-myb / Q000378:metabolism*
chemical_list: D020598:Proto-Oncogene Proteins c-myb