title: Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men.
abstract: OBJECTIVE
  The objective was to determine the effects of lycopene supplementation on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) and oxidative stress.
  
  
  METHODS
  Healthy men (n=126) were randomized to receive placebo (n=38), 6 mg (n=41), or 15 mg (n=37) lycopene daily for 8-week.
  
  
  RESULTS
  Serum lycopene increased in a dose-dependent manner after 8-week supplementation (P<0.001). The 15 mg/day group had greater increase in plasma SOD activity (P=0.014) and reduction in lymphocyte DNA comet tail length (P=0.042) than the placebo group. Intragroup comparison revealed a 23% increase in RH-PAT index from baseline (1.45±0.09 vs. 1.79±0.12; P=0.032) in the 15 mg/day group after 8-week. hs-CRP, systolic blood pressure, sICAM-1 and sVCAM-1 significantly decreased, and β-carotene and LDL-particle size significantly increased only in the 15 mg/day group. Interestingly, the beneficial effect of lycopene supplementation on endothelial function (i.e., RH-PAT and sVCAM-1) were remarkable in subjects with relatively impaired endothelial cell function at initial level. Changes in RH-PAT index correlated with SOD activity (r=0.234, P=0.017) especially in the 15 mg lycopene/day group (r=0.485, P=0.003), lymphocyte DNA comet tail moment (r=-0.318, P=0.001), and hs-CRP (r=-0.238, P=0.011). In addition, changes in lycopene correlated with hs-CRP (r=-0.230, P=0.016) and SOD activity (r=0.205, P=0.037).
  
  
  CONCLUSIONS
  An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function.
authors.affiliation: Yonsei University Research Institute of Science for Aging, National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, Yonsei University, Seoul, Republic of Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Jean Kyung
authors.initials: JK
authors.lastname: Paik
authors.forename: Oh Yoen
authors.initials: OY
authors.lastname: Kim
authors.forename: Hae Won
authors.initials: HW
authors.lastname: Park
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D002338:Carotenoids / Q000097:blood / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D019587:Dietary Supplements; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D008077:Lipoproteins, LDL / Q000097:blood; D000077276:Lycopene; D008297:Male; D008365:Manometry; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D010316:Particle Size; D013482:Superoxide Dismutase / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D019207:beta Carotene / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D019010:Vascular Cell Adhesion Molecule-1; D019207:beta Carotene; D002338:Carotenoids; D002097:C-Reactive Protein; D013482:Superoxide Dismutase; D000077276:Lycopene