title: Deterministic and stochastic simulation and analysis of biochemical reaction networks the lactose operon example.
abstract: A brief introduction to mathematical modeling of biochemical regulatory reaction networks is presented. Both deterministic and stochastic modeling techniques are covered with examples from enzyme kinetics, coupled reaction networks with oscillatory dynamics and bistability. The Yildirim-Mackey model for lactose operon is used as an example to discuss and show how deterministic and stochastic methods can be used to investigate various aspects of this bacterial circuit.
authors.affiliation: Division of Natural Sciences, New College of Florida, Sarasota, Florida, USA.
authors.forename: Necmettin
authors.initials: N
authors.lastname: Yildirim
authors.forename: Caner
authors.initials: C
authors.lastname: Kazanci
mesh_terms: D003198:Computer Simulation; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D007700:Kinetics; D007763:Lac Operon / Q000235:genetics; D008954:Models, Biological; D001616:beta-Galactosidase / Q000235:genetics / Q000378:metabolism
chemical_list: D001616:beta-Galactosidase