title: The annotation of the asparagine N-linked glycosylation pathway in the Reactome database.
abstract: Asparagine N-linked glycosylation is one of the most important forms of protein post-translational modification in eukaryotes and is one of the first metabolic pathways described at a biochemical level. Here, we report a new annotation of this pathway for the Human species, published after passing a peer-review process in Reactome. The new annotation presented here offers a high level of detail and provides references and descriptions for each reaction, along with integration with GeneOntology and other databases. The open-source approach of Reactome toward annotation encourages feedback from its users, making it easier to keep the annotation of this pathway updated with future knowledge. Reactome's web interface allows easy navigation between steps involved in the pathway to compare it with other pathways and resources in other scientific databases and to export it to BioPax and SBML formats, making it accessible for computational studies. This new entry in Reactome expands and complements the annotations already published in databases for biological pathways and provides a common reference to researchers interested in studying this important pathway in the human species. Finally, we discuss the status of the annotation of this pathway and point out which steps are worth further investigation or need better experimental validation.
authors.affiliation: Institute of Evolutionary Biology, Carrer Doctor Aiguader 88, Barcelona, Catalonia, Spain.
authors.forename: Giovanni Marco
authors.initials: GM
authors.lastname: Dall'Olio
authors.forename: Bijay
authors.initials: B
authors.lastname: Jassal
authors.forename: Ludovica
authors.initials: L
authors.lastname: Montanucci
authors.forename: Pascal
authors.initials: P
authors.lastname: Gagneux
authors.forename: Jaume
authors.initials: J
authors.lastname: Bertranpetit
authors.forename: Hafid
authors.initials: H
authors.lastname: Laayouni
mesh_terms: D001216:Asparagine / Q000378:metabolism*; D030562:Databases, Protein; D006031:Glycosylation; D006801:Humans; D053858:Metabolic Networks and Pathways; D058977:Molecular Sequence Annotation; D011134:Polysaccharides / Q000096:biosynthesis; D011499:Protein Processing, Post-Translational; D021381:Protein Transport
chemical_list: D011134:Polysaccharides; D001216:Asparagine