title: Coronary artery aneurysms in Wegener's granulomatosis.
abstract: Atherosclerosis is the main cause of coronary artery aneurysm, however they can be observed in connective tissue diseases such as systemic lupus erythematosus and vasculitis. Kawasaki's disease and polyarteritis nodosa (PAN) are the systemic vasculitis that more often present coronary artery aneurysms. There are descriptions in the literature that small vessel vasculitis such as microscopic polyangiitis and PAN could develop coronary artery aneurysm, which are infrequent in other ANCA-associated vasculitis. Here, we report the case of a 25-year-old man who developed an extensive anterior myocardial infarct. The coronary angiogram showed coronary artery aneurysms, on laboratory ANCA C positivity with elevated levels of anti-proteinase 3 antibodies were present. He was treated with high doses of corticosteroids and cyclophosphamide with resolution of the aneurysms.
authors.affiliation: Section of Rheumatology and Autoimmune Diseases, Hospital J.B. Iturraspe, boulevard Pellegrini 3551, CP 3000, Santa Fe, Argentina. reumatologia.iturraspe@gmail.com
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Musuruana
authors.forename: Javier A
authors.initials: JA
authors.lastname: Cavallasca
authors.forename: Juan
authors.initials: J
authors.lastname: Berduc
authors.forename: José
authors.initials: J
authors.lastname: Vicario
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis / Q000276:immunology; D003323:Coronary Aneurysm / Q000175:diagnosis* / Q000209:etiology; D017023:Coronary Angiography / Q000379:methods; D003520:Cyclophosphamide / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D053146:Myeloblastin / Q000032:analysis / Q000276:immunology; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D003520:Cyclophosphamide; D053146:Myeloblastin; D008775:Methylprednisolone