title: Atherosclerotic and thrombophilic risk factors in patients with ischemic central retinal vein occlusion.
abstract: OBJECTIVE
  To investigate atherosclerotic and thrombophilic risk factors in patients affected by acute ischemic and nonischemic central retinal vein occlusions (CRVOs).
  
  
  METHODS
  One hundred and three patients with acute unilateral CRVO (41 ischemic and 62 nonischemic) were studied. The frequency of traditional cardiovascular risk factors was assessed, and the plasma levels of a variety of thrombophilic markers were measured. Univariate logistic regression was performed to determine risk factors for ischemic CRVO.
  
  
  RESULTS
  Arterial hypertension, hypercholesterolemia, postmethionine hyperhomocysteinemia (HHcy), elevated factor VIII, and reduced folic acid and B6 plasma levels were more frequent in patients with ischemic CRVO than in those with nonischemic CRVO (P = 0.030, P = 0.025, P = 0.011, P < 0.001, P < 0.001, and P = 0.044, respectively). Risk factors for ischemic CRVO were arterial hypertension (odds ratio [OR], 3.22; 95% confidence interval [CI], 1.13-9.21; P = 0.037), hypercholesterolemia (OR, 3.03; 95% CI, 1.06-8.65; P = 0.042), reduced folic acid levels (OR, 6.77; 95% CI, 1.59-28.79; P = 0.011), and elevated FVIII levels (OR, 6.17; 95% CI, 2.56-14.82; P < 0.001). Postmethionine HHcy was associated with low folic acid levels (r = -0.413; P = 0.007; OR, 9.33; 95% CI, 2.06-42.18; P = 0.005).
  
  
  CONCLUSIONS
  The results of the present study suggest that some atherosclerotic and thrombophilic risk factors may increase the risk of having an ischemic form of CRVO.
authors.affiliation: Eye Clinic, University of Florence, Florence, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sodi
authors.forename: Barbara
authors.initials: B
authors.lastname: Giambene
authors.forename: Rossella
authors.initials: R
authors.lastname: Marcucci
authors.forename: Francesco
authors.initials: F
authors.lastname: Sofi
authors.forename: Sandra
authors.initials: S
authors.lastname: Fedi
authors.forename: Rosanna
authors.initials: R
authors.lastname: Abbate
authors.forename: Domenico
authors.initials: D
authors.lastname: Prisco
authors.forename: Ugo
authors.initials: U
authors.lastname: Menchini
mesh_terms: D000208:Acute Disease; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D050171:Dyslipidemias / Q000150:complications; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D007511:Ischemia / Q000097:blood / Q000209:etiology*; D008297:Male; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood / Q000150:complications*
chemical_list: D015415:Biomarkers; D006710:Homocysteine; C078147:F8 protein, human; D005169:Factor VIII; D005492:Folic Acid