title: Evolution of YidC/Oxa1/Alb3 insertases: three independent gene duplications followed by functional specialization in bacteria, mitochondria and chloroplasts.
abstract: Members of the YidC/Oxa1/Alb3 protein family facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria and the thylakoid membrane of plastids. All homologs share a conserved hydrophobic core region comprising five transmembrane domains. On the basis of phylogenetic analyses, six subgroups of the family can be distinguished which presumably arose from three independent gene duplications followed by functional specialization. During evolution of bacteria, mitochondria and chloroplasts, subgroup-specific regions were added to the core domain to facilitate the association with ribosomes or other components contributing to the substrate spectrum of YidC/Oxa1/Alb3 proteins.
authors.affiliation: Departamento de Genética Molecular, Instituto de Fisiología Celular, Circuito Exterior s/n, Ciudad Universitaria, Universidad Nacional Autónoma de México, Mexico D.F. 04510, Mexico.
authors.forename: Soledad
authors.initials: S
authors.lastname: Funes
authors.forename: Frank
authors.initials: F
authors.lastname: Kauff
authors.forename: Eli O
authors.initials: EO
authors.lastname: van der Sluis
authors.forename: Martin
authors.initials: M
authors.lastname: Ott
authors.forename: Johannes M
authors.initials: JM
authors.lastname: Herrmann
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D002736:Chloroplasts / Q000201:enzymology / Q000235:genetics; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D020440:Gene Duplication; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D017510:Protein Folding
chemical_list: D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D009687:Nuclear Proteins; C090858:OXA1 protein; D003576:Electron Transport Complex IV