title: Bone maturation in 1788 children and adolescents with diabetes mellitus type 1.
abstract: Diabetes mellitus type 1 might interfere with pubertal development. Particularly, long-term metabolic control and intensity of insulin treatment have been reported to contribute to a delay in pubertal onset. Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria with type 1 diabetes. Bone age was retarded by -0.27 +/- 1.1 years in the whole group, but particularly in the adolescents at the end of puberty (>16 years; -0.76 +/- 1.29y). Bone age delay was more pronounced in boys, and in children with long-term median HbAlc levels of 7.5 - 9.0%. No associations were found with current HbAlc levels or the intensity of insulin treatment. Bone age determinations in diabetic children should only be performed when clinical signs of impaired somatic development are present. In addition, the potential influence of diabetes on bone development needs to be considered in the interpretation of carpograms.
authors.affiliation: Department of Pediatrics, University of Jena, Germany. Axel.Dost@med.uni-jena.de
authors.forename: Axel
authors.initials: A
authors.lastname: Dost
authors.forename: Tilman
authors.initials: T
authors.lastname: Rohrer
authors.forename: Jörg
authors.initials: J
authors.lastname: Fussenegger
authors.forename: Christian
authors.initials: C
authors.lastname: Vogel
authors.forename: Bernd
authors.initials: B
authors.lastname: Schenk
authors.forename: Martin
authors.initials: M
authors.lastname: Wabitsch
authors.forename: Beate
authors.initials: B
authors.lastname: Karges
authors.forename: Claudia
authors.initials: C
authors.lastname: Vilser
authors.forename: Reinhard W
authors.initials: RW
authors.lastname: Holl
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D001846:Bone Development; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human