title: Role of dendritic cells in atopic dermatitis: an update.
abstract: Dendritic cells (DCs) have been recognized as key players bridging innate and adaptive immune systems. They control the balance of the adaptive immune response, and the functional behavior of DCs is mainly dictated by their microenvironment. Atopic dermatitis (AD) is a paradigmatic disease where the inflammatory microenvironment has a deep impact on DCs. The emergence of IgE-mediated sensitization is tightly related to the impact of locally released cytokines by either keratinocytes, T cells, or other cells involved in the inflammatory reaction. This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD.
authors.affiliation: Department of Dermatology and Allergy, University of Bonn Medical Center, Germany. Thomas.Bieber@ukb.uni-bonn.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Bieber
authors.forename: Natalija
authors.initials: N
authors.lastname: Novak
authors.forename: Nadine
authors.initials: N
authors.lastname: Herrmann
authors.forename: Nadine
authors.initials: N
authors.lastname: Herrman
authors.forename: Susanne
authors.initials: S
authors.lastname: Koch
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism