title: [Study on excretion of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion].
abstract: The excretion characteristics of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion in bile, urine and feces after oral administration to rats were studied. Bile for 24 h, urine and feces for 72 h were collected. The content of THSG was determined by HPLC-UV. The established HPLC-UV method was available for the analysis of THSG in excreta and corresponded to the requirement of biological sample analysis. After given THSG and its beta-cyclodextrin inclusion, the amount of prototype THSG in feces were 3.27% and 0.61%, meanwhile THSG in bile were 0.20% and 0.18%, respectively. Only a little THSG was found in urine. The result showed that beta-cyclodextrin inclusion reduced the fecal excretion of THSG. However, the characteristic of urinary and biliary excretion wasn't changed.
authors.affiliation: College of Traditional Chinese Medicine, TianJin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Ren
authors.forename: Huizi
authors.initials: H
authors.lastname: Ouyang
authors.forename: Guifang
authors.initials: G
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Aidi
authors.initials: A
authors.lastname: Qi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005243:Feces; D006027:Glycosides / Q000737:chemistry*; D002479:Inclusion Bodies / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000378:metabolism*
chemical_list: D006027:Glycosides; D013267:Stilbenes; D047392:beta-Cyclodextrins; C031215:betadex