title: Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn.
abstract: OBJECTIVE
  This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models.
  
  
  METHODS
  Ethyl acetate extract of V. leucoxylon Linn. evaluated for anti-inflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model.
  
  
  RESULTS
  Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h.
  
  
  CONCLUSIONS
  This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity.
authors.affiliation: Pranveer Singh Institute of Technology, Kanpur, India.
authors.forename: Padmini
authors.initials: P
authors.lastname: Shukla
authors.forename: P
authors.initials: P
authors.lastname: Shukla
authors.forename: S B
authors.initials: SB
authors.lastname: Mishra
authors.forename: B
authors.initials: B
authors.lastname: Gopalakrishna