title: [Drooling following radiation. Botulinum toxin as a successful treatment modality].
abstract: Drooling is both a clinical sign for the diminished control of saliva and oral motor function and a heavy social burden for patients. We report a case in which drooling deteriorated after radiotherapy of the head and neck region as the primary treatment for hypopharyngeal cancer, although radiotherapy of the salivary glands is known to be an effective treatment option for drooling. In this particular case, injection of botulinum toxin in the parotid and submandibular glands significantly reduced drooling. The excellent response to botulinum toxin is of great clinical interest for similar RT non-responders.
authors.affiliation: Klinik für Hals-, Nasen- und Ohrenheilkunde, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. armin.steffen@uk-sh.de
authors.forename: A
authors.initials: A
authors.lastname: Steffen
authors.forename: B
authors.initials: B
authors.lastname: Wollenberg
authors.forename: R
authors.initials: R
authors.lastname: Schönweiler
authors.forename: N
authors.initials: N
authors.lastname: Brüggemann
authors.forename: T
authors.initials: T
authors.lastname: Meyners
mesh_terms: D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage; D001905:Botulinum Toxins / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D012798:Sialorrhea / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins