title: Human papillomavirus infection in Honduran women with cervical intraepithelial neoplasia or cervical cancer.
abstract: OBJECTIVE
  The aims of this study were to investigate human papillomavirus (HPV) genotypes in women with cervical intraepithelial lesions and cervical cancer (CC) in Honduras and to identify epidemiological cofactors that contribute to the development of CC.
  
  
  METHODS
  Among the 289 patients analyzed, 139 had low-grade squamous intraepithelial lesion (LSIL), 60 had high-grade squamous intraepithelial lesion (HSIL), and 90 had CC.
  
  
  RESULTS
  The HPV DNA was detected in 113 women (81%) with LSIL, in 58 women (97%) with HSIL, and in 84 women (93%) with CC. Twenty-five HPV genotypes were found. Human papillomavirus type 16 was detected in 41% of women with CC, in 35% of women with HSIL, and in 24% of women with LSIL. Human papillomavirus type 18 was found in 9% of women with CC, in 4% of women with HSIL, and 5% of women with LSIL.
  
  
  CONCLUSIONS
  Therefore, implementation of the prophylactic vaccines against HPV genotypes 16 and 18 has the potential of preventing at least a quarter of LSIL, one third of HSIL, and about half of CC cases in Honduras.
authors.affiliation: School of Microbiology, Science Faculty, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
authors.forename: Nelba
authors.initials: N
authors.lastname: Tabora
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bulnes
authors.forename: Luis A
authors.initials: LA
authors.lastname: Toro
authors.forename: José M
authors.initials: JM
authors.lastname: Claros
authors.forename: Leon F A G
authors.initials: LF
authors.lastname: Massuger
authors.forename: Wim G V
authors.initials: WG
authors.lastname: Quint
authors.forename: Willem J G
authors.initials: WJ
authors.lastname: Melchers
authors.forename: Anabelle
authors.initials: A
authors.lastname: Ferrera
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D006721:Honduras / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000821:virology*