title: Microwave assisted nanoparticle surface functionalization.
abstract: We introduce the input of microwave energy to elaborate a multimodal magnetic nanoplatform. This magnetic nanomaterial consists of superparamagnetic γFe(2)O(3) nanoparticles conjugated to hydroxymethylene bisphosphonate (HMBP) molecules with an amine function as the terminal group. The feasibility of such a process is illustrated by the coupling of Rhodamine B to the hybrid magnetic nanomaterial. Using a microwave we manage to have approximately a 50 fold increase in molecules per nanoparticle compared to conventional procedures. Moreover we show that the amount of Rhodamine on the nanoparticle surface could be tuned using various stoichiometric ratios. The presence of Rhodamine B on the nanoparticle surface provides an amphiphilic character to facilitate penetration into the cells.
authors.affiliation: CSPBAT laboratory, FRE 3043 CNRS, University Paris 13, Bobigny, France.
authors.forename: F
authors.initials: F
authors.lastname: Benyettou
authors.forename: E
authors.initials: E
authors.lastname: Guenin
authors.forename: Y
authors.initials: Y
authors.lastname: Lalatonne
authors.forename: L
authors.initials: L
authors.lastname: Motte
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D057446:Hydrodynamics; D008027:Light; D008872:Microwaves; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D012235:Rhodamines; D012542:Scattering, Radiation; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D012235:Rhodamines; D012996:Solutions; D014867:Water