title: Response and safety of sunitinib in a heavily pre-treated metastatic non-small cell lung carcinoma patient.
abstract: BACKGROUND
  The activity of sunitinib, a multitargeted tyrosine kinase inhibitor with antiangiogenic and antitumor activities, has been explored in several solid malignancies such as breast, lung, prostate and pancreatic cancer. Currently it is approved for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Non-small cell lung cancer usually presents at an advanced or metastatic stage at diagnosis. Treatment options are limited for this disease, therefore symptom palliation and patient's quality of life are primary objectives of therapy.
  
  
  METHODS
  We describe the case of a patient (male, 67 years old) with heavily pre-treated metastatic non-small cell lung carcinoma who received sunitinib according to the following 3-week schedule: 50 mg daily for 2 weeks followed by a 1-week rest. The patient completed six months of therapy achieving a major disease response without high-grade toxicities.
  
  
  CONCLUSIONS
  In this case, sunitinib shows promising single-agent activity in pretreated non-small cell lung cancer, with a good toxicity profile and flexible administration schedule.
authors.affiliation: Department of Oncology, Centre of Experimental and Clinical Oncology, Florence University, Florence, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Tassi
authors.forename: A
authors.initials: A
authors.lastname: Muto
authors.forename: S
authors.initials: S
authors.lastname: Rangan
authors.forename: A
authors.initials: A
authors.lastname: Vannini
authors.forename: L
authors.initials: L
authors.lastname: Politi
authors.forename: B
authors.initials: B
authors.lastname: Neri
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D004334:Drug Administration Schedule; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000009:adverse effects; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D011758:Pyrroles / Q000008:administration & dosage* / Q000009:adverse effects; D000077210:Sunitinib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib