title: Myb proteins: angels and demons in normal and transformed cells.
abstract: A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor regulates the expression of hundreds of genes and is in turn regulated by numerous pathways and protein interactions. However, the most unique feature of c-Myb is that it can be converted into an oncogenic transforming protein through a few mutations that completely change its activity and specificity. The c-Myb protein is a myriad of interactions and activities rolled up in a protein that controls proliferation and differentiation in many different cell types. Here we discuss the background and recent progress that have led to a better understanding of this complex protein, and outline the questions that have yet to be answered.
authors.affiliation: Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Scott A
authors.initials: SA
authors.lastname: Ness
mesh_terms: D017398:Alternative Splicing / Q000502:physiology; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000235:genetics; D035683:MicroRNAs / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology; D020626:Oncogene Proteins v-myb / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D020598:Proto-Oncogene Proteins c-myb / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000187:drug effects; D015534:Trans-Activators / Q000378:metabolism; D051153:Wnt Proteins / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C088831:MYBL1 protein, human; C064352:MYBL2 protein, human; D035683:MicroRNAs; D020626:Oncogene Proteins v-myb; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D015534:Trans-Activators; D051153:Wnt Proteins