title: Chemomodulatory effects of Aegle marmelos against DMBA-induced skin tumorigenesis in Swiss albino mice.
abstract: Aegle marmelos is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. In the present study, cancer chemopreventive properties were evaluated on 7, 12-dimethylbenz (a) anthracene (DMBA) induced skin papillomagenesis in Swiss albino mice. A single topical application of DMBA, followed 2 weeks later by repeated application of croton oil till the end of the experiment ( i.e. 16 weeks) caused a 100% tumor incidence. In contrast, mice treated with the AME (50 mg/kg b. wt./animal/day) in the peri-initiational phase (i.e. 7 days before and 7 days after DMBA application; Group IV) and post-initiational phase (from the day of croton oil treatment till the end of the experiment; Group V), exhibited a significant reduction to 70 and 50% respectively. The cumulative number of papillomas after 16 weeks was 67 in the control group, but 26 and 23 in the animals treated with AME at peri-initiational and post-initiational stages, respectively. The tumor burden and tumor yield were significantly decreased (Group IV-3.7, 2.6; Group V- 4.6, 2.3) as compared to carcinogen treated control group (6.7, 6.7). The present study demonstrates the chemopreventive potential of Aegle marmelos fruit extract on DMBA induced skin tumorigenesis in mice.
authors.affiliation: Department of Zoology, University of Rajasthan, India.
authors.forename: Annapurna
authors.initials: A
authors.lastname: Agrawal
authors.forename: Preeti
authors.initials: P
authors.lastname: Verma
authors.forename: P K
authors.initials: PK
authors.lastname: Goyal
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D045471:Aegle; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D018890:Chemoprevention; D003436:Croton Oil / Q000494:pharmacology; D008515:Medicine, Ayurvedic; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D028321:Plant Preparations; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D028321:Plant Preparations; D015127:9,10-Dimethyl-1,2-benzanthracene; D003436:Croton Oil