title: The multidrug transporter Pdr5: a molecular diode?
abstract: A subset of the family of ATP-binding cassette (ABC) transporters has been in focus owing to their involvement in conferring multidrug resistance in cancer cells and among immune compromised individuals. Saccharomyces cerevisiae is protected against xenobiotics by similar machineries that are part of the pleitropic drug resistance (PDR) network. The ABC transporter Pdr5 is an important member of this PDR network in yeast and is involved in cellular detoxification by the efflux of a wide variety of drugs and substrates. In this review, we focus on the aspects of detergent effects and the degeneracy in conserved sequences that is observed in the nucleotide binding domains of Pdr5 and discuss their functional relevance.
authors.affiliation: Institute of Biochemistry, Heinrich Heine University, Universitätsstrasse 1, Düsseldorf, Germany.
authors.forename: Rakeshkumar P
authors.initials: RP
authors.lastname: Gupta
authors.forename: Petra
authors.initials: P
authors.lastname: Kueppers
authors.forename: Lutz
authors.initials: L
authors.lastname: Schmitt
authors.forename: Robert
authors.initials: R
authors.lastname: Ernst
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D001692:Biological Transport; D008954:Models, Biological; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D013379:Substrate Specificity; D013499:Surface Properties
chemical_list: D018528:ATP-Binding Cassette Transporters; D000251:Adenosine Triphosphatases; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D029701:Saccharomyces cerevisiae Proteins; C092438:PDR5 protein, S cerevisiae