title: Precursor-T lymphoblastic lymphoma after unrelated bone marrow transplantation in a patient with Fanconi anemia.
abstract: Lymphoid malignancies are rare in patients with Fanconi anemia (FA), particularly after bone marrow transplantation. A boy, who was diagnosed with FA at the age of 5; underwent successful bone marrow transplantation at the age of 11. One year later, he presented with fever and dry cough, and was found to have an anterior mediastinal tumor. Biopsy of the tumor revealed precursor-T cell lymphoblastic lymphoma. Human leukocyte antigen analysis confirmed that the tumor cells were derived from the patient's own cells. He received mild chemotherapy for lymphoma, but his condition deteriorated rapidly and he died from excessive chemotherapy-related toxicity. The literature contains no reports of successful chemotherapy for lymphoid tumors in patients with FA, and therefore, alternatives to chemotherapy should be considered in the treatment of such patients.
authors.affiliation: Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo, Japan. d-suzuki@chashu.org
authors.forename: Daisuke
authors.initials: D
authors.lastname: Suzuki
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Kazue
authors.initials: K
authors.lastname: Yasuda
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakagawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Morimoto
authors.forename: Miharu
authors.initials: M
authors.lastname: Yabe
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Yabe
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002675:Child, Preschool; D005199:Fanconi Anemia / Q000628:therapy*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy