title: Familial gastric cancer: update for practice management.
abstract: About 90% of gastric carcinoma presents a sporadic setting and only 10% shows a familial cluster; among this group, 1-3% are considered as hereditary syndromes, with a clear genetic pathway. The most important genetic mechanisms are associated with CDH1 germline mutations, causing the hereditary diffuse gastric cancer syndrome. Other inherited predispositions with gastric carcinoma are the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz-Jeghers syndromes. In this brief update, we described these principal hereditary syndromes offering a simple management to physicians where are these diseases diagnosed.
authors.affiliation: Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy. corso.giov@tiscali.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corso
authors.forename: Daniele
authors.initials: D
authors.lastname: Marrelli
authors.forename: Franco
authors.initials: F
authors.lastname: Roviello
mesh_terms: D015820:Cadherins / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D053843:DNA Mismatch Repair; D004781:Environmental Exposure; D016158:Genes, p53; D005820:Genetic Testing; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000628:therapy
chemical_list: D015820:Cadherins