title: Plk4/SAK/ZYG-1 in the regulation of centriole duplication.
abstract: Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication. Several recent studies have elucidated the regulated activity of these kinases and potential downstream targets for centriole assembly.
authors.affiliation: University of Colorado, Molecular, Cellular and Developmental Biology Porter Biosciences #416, CB0347, Boulder, CO 80309-0347 USA.
authors.forename: Chad G
authors.initials: CG
authors.lastname: Pearson
authors.forename: Mark
authors.initials: M
authors.lastname: Winey