title: Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke.
abstract: OBJECTIVE
  Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding.
  
  
  METHODS
  We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects.
  
  
  RESULTS
  sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024).
  
  
  CONCLUSIONS
  Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.
authors.affiliation: Monash University, Melbourne VI, Australia. mohammad.al-tamimi@monash.edu
authors.forename: Mohammad
authors.initials: M
authors.lastname: Al-Tamimi
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Gardiner
authors.forename: Jim Y
authors.initials: JY
authors.lastname: Thom
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Cooper
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: Hankey
authors.forename: Michael C
authors.initials: MC
authors.lastname: Berndt
authors.forename: Ross I
authors.initials: RI
authors.lastname: Baker
authors.forename: Robert K
authors.initials: RK
authors.lastname: Andrews
mesh_terms: D000208:Acute Disease; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000209:etiology* / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D012995:Solubility; D020521:Stroke / Q000097:blood* / Q000209:etiology* / Q000473:pathology
chemical_list: D015415:Biomarkers; D010980:Platelet Membrane Glycoproteins; C098341:platelet membrane glycoprotein VI