title: Retrobulbar optic neuritis associated with infliximab in a patient with Crohn's disease.
abstract: OBJECTIVE
  : Infliximab is a chimeric human-murine monoclonal antibody with a high affinity and specificity for tumor necrosis factor α, which is nowadays widely used in Crohn's disease. An exacerbation of demyelinating disease as an adverse effect of this treatment is rare. The aim of this study was to discuss the relationship between infliximab and optic neuritis.
  
  
  METHODS
  : We describe a 55-year old man with Crohn's disease who developed retrobulbar optic neuritis of the left eye after the infusion of infliximab. The outcome was favorable after systemic steroid treatment.
  
  
  CONCLUSIONS
  : Although the relationship between the onset of visual symptoms and the infusion of infliximab may have been coincidental, we believe that this case report underscores the clinical awareness of the possible association, especially in light of the increasing use of this cytokine inhibitor.
authors.affiliation: Department of gastroenterology, Habib Thameur Hospital, Tunis, Tunisia.
authors.forename: Asma
authors.initials: A
authors.lastname: Ouakaa-Kchaou
authors.forename: Dalila
authors.initials: D
authors.lastname: Gargouri
authors.forename: Sonia
authors.initials: S
authors.lastname: Trojet
authors.forename: Rania
authors.initials: R
authors.lastname: Hefaiedh
authors.forename: Hela
authors.initials: H
authors.lastname: Elloumi
authors.forename: Asma
authors.initials: A
authors.lastname: Kochlef
authors.forename: Afef
authors.initials: A
authors.lastname: Kilani
authors.forename: Malika
authors.initials: M
authors.lastname: Romani
authors.forename: Jamel
authors.initials: J
authors.lastname: Kharrat
authors.forename: Abdeljabbar
authors.initials: A
authors.lastname: Ghorbel