title: Scleredema treated with broad-band ultraviolet A phototherapy plus colchicine.
abstract: Scleredema is an uncommon condition characterized by induration of skin. The pathogenesis is not known, although the increased expression of collagen-producing fibroblasts in the skin has been demonstrated. Scleredema has been difficult to treat with scattered reports of success with bath psoralen plus ultraviolet A (PUVA), cream PUVA, UVA1 and others. The use of low-dose broad-band UVA phototherapy was found to be effective in the treatment of morphea. Colchicine has been shown to interfere with collagen synthesis and is used successfully in scleroderma. We report the first case of scleredema that improved markedly with low-dose broad-band UVA plus colchicine treatment.
authors.affiliation: Department of Dermatology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. typejaleyuksek@mynet.com
authors.forename: Jale
authors.initials: J
authors.lastname: Yüksek
authors.forename: Engin
authors.initials: E
authors.lastname: Sezer
authors.forename: Doğan
authors.initials: D
authors.lastname: Köseoğlu
authors.forename: Fatma
authors.initials: F
authors.lastname: Markoç
authors.forename: Havva
authors.initials: H
authors.lastname: Yıldız
mesh_terms: D000328:Adult; D003078:Colchicine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D012592:Scleredema Adultorum / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D050257:Tubulin Modulators / Q000627:therapeutic use*; D014467:Ultraviolet Therapy; D055815:Young Adult
chemical_list: D050257:Tubulin Modulators; D003078:Colchicine