title: An examination of candidate gene SNPs for dyslexia in an Indian sample.
abstract: Developmental dyslexia (DD) is a complex neuro-genetic disorder associated with difficulty in learning to read despite adequate intelligence and educational opportunities. Studies in different populations have established associations between DD and single nucleotide polymorphisms (SNPs) in a number of candidate genes, including DYX1C1, KIAA0319 and DCDC2. In an ongoing DD study in India, we screened twenty SNPs located within the coding region of these three candidate genes by mass-ARRAY technique. At this point, there is no statistical evidence of association between the allelic variation in the three candidate genes and DD in our sample, although there might be some promising leads for future research that should involve a large and a better characterized sample.
authors.affiliation: Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India.
authors.forename: Shyamala K
authors.initials: SK
authors.lastname: Venkatesh
authors.forename: Anand
authors.initials: A
authors.lastname: Siddaiah
authors.forename: Prakash
authors.initials: P
authors.lastname: Padakannaya
authors.forename: Nallur B
authors.initials: NB
authors.lastname: Ramachandra
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D003431:Cross-Cultural Comparison; D003598:Cytoskeletal Proteins; D004410:Dyslexia / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D014644:Genetic Variation; D006801:Humans; D007194:India; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D003598:Cytoskeletal Proteins; C510451:DCDC2 protein, human; C478878:DNAAF4 protein, human; C500377:KIAA0319 protein, human; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins