title: Science to practice: versatile method to track transplanted encapsulated islet cells with multiple imaging modalities.
abstract: Pancreatic islet transplantation may provide an effective therapy for patients with type I diabetes. By encapsulating islets in alginate capsules, their survival is substantially improved. Methods to monitor the distribution of the encapsulated islets during delivery and afterward would help to optimize this type of therapy. Barnett and coworkers (1) showed, for the first time, it is possible to visualize encapsulated islets by using magnetic resonance (MR) imaging, computed tomography (CT), and ultrasonography (US) after the inclusion of perfluorocarbon in the capsules. Importantly, it was shown that the therapeutic effect of the islets was sustained for more than 50 days when implanted into mice.
authors.affiliation: Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234 New York, NY 10029, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Cormode
authors.forename: Willem J M
authors.initials: WJ
authors.lastname: Mulder
authors.forename: Zahi A
authors.initials: ZA
authors.lastname: Fayad
mesh_terms: D000464:Alginates / Q000494:pharmacology; D000818:Animals; D002214:Capsules / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D003952:Diagnostic Imaging; D005466:Fluorocarbons / Q000494:pharmacology; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D016381:Islets of Langerhans Transplantation; D008279:Magnetic Resonance Imaging; D051379:Mice; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000464:Alginates; D002214:Capsules; D005466:Fluorocarbons; D006603:Hexuronic Acids; D020723:Glucuronic Acid