title: Sarcoidosis-associated hepatocellular carcinoma.
abstract: Sarcoidosis is a systemic granulomatous inflammation of unknown etiology, and seems to involve the liver parenchyma in most cases. However, sarcoidosis-associated hepatocellular carcinoma is rare. We report here a case in which a hepatocellular carcinoma occurred within the liver, which was probably involved as a result of systemic sarcoidosis. A 57-year-old Japanese man had been followed up for 2 years because of diabetic nephropathy and sarcoidosis. On admission for pneumonia, imaging studies revealed an unexpected hepatic tumor. Histology revealed a hepatocellular carcinoma accompanied by T-lymphocytic infiltration and marked granulomatous inflammation, which was surrounding some tumor nodules. The background liver parenchyma exhibited a moderate degree of fibrosis with granulomatous inflammation. The patient had no other apparent liver disease such as viral hepatitis, steatohepatitis, or primary biliary cirrhosis. Therefore, in the present case, sarcoidosis may be considered the probable background etiology for hepatocarcinogenesis.
authors.affiliation: Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513. sogata@ndmc.ac.jp
authors.forename: Sho
authors.initials: S
authors.lastname: Ogata
authors.forename: Takuya
authors.initials: T
authors.lastname: Horio
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sugiura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Shimazaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Saito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Aiko
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kawai
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome