title: Dendritic and spinal pathology in the acoustic cortex in Alzheimer's disease: morphological estimation in Golgi technique and electron microscopy.
abstract: CONCLUSIONS
  The morphological and morphometric estimation of the dendrites and the dendritic spines in the acoustic cortex in Alzheimer's disease revealed substantial alterations of the dendritic arborization and marked loss of the dendritic spines, which may be related to communication impairment even in early cases of Alzheimer's disease.
  
  
  OBJECTIVE
  Alzheimer's disease is characterized by progressive loss of memory, impairment of judgment, and decline in communication and speech eloquence. In the present study we attempted to describe the morphological and morphometric alterations of the dendrites and the dendritic spines in the acoustic cortex in early cases of Alzheimer's disease, in order to approach the communication impairment of patients suffering from Alzheimer's disease from a neuropathological point of view.
  
  
  METHODS
  We studied the acoustic cortex in 22 cases of Alzheimer's disease by Golgi technique and electron microscopy.
  
  
  RESULTS
  The morphological and morphometric estimation of the acoustic cortex revealed loss of Cajal-Retzius cells in layer I, as well as an impressive abbreviation of the dendritic fields associated with loss of dendritic spines in all the layers of the cortex. Numerous distorted, dystrophic, and degenerated dendritic spines were also seen, which were intermixed with a considerable number of giant spines. The dendritic and spinal alterations were closely associated with mitochondrial alterations.
authors.affiliation: Department of Neurology, Aristotelian University, Thessaloniki, Greece. sibh844@otenet.gr
authors.forename: Stavros J
authors.initials: SJ
authors.lastname: Baloyannis
authors.forename: Spyros L
authors.initials: SL
authors.lastname: Manolides
authors.forename: Leonidas S
authors.initials: LS
authors.lastname: Manolides
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology*; D001303:Auditory Cortex / Q000473:pathology*; D002452:Cell Count; D016923:Cell Death / Q000502:physiology; D049229:Dendritic Spines / Q000473:pathology*; D005260:Female; D006056:Golgi Apparatus / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000473:pathology; D009474:Neurons / Q000473:pathology; D012016:Reference Values; D013116:Spinal Cord / Q000473:pathology*