title: Pemetrexed-induced eyelid edema: incidence and clinical manifestations.
abstract: BACKGROUND
  Pemetrexed-induced eyelid edema is a rare side-effect of pemetrexed treatment.
  
  
  METHODS
  Retrospective analysis of the incidence and severity of eyelid edema was conducted in patients treated with pemetrexed in a single institution.
  
  
  RESULTS
  Eighty-six patients received pemetrexed-containing chemotherapy either as a single agent (45 patients) or in combination with cis- or carboplatin (41 patients). Two patients (2.3%) with stage IV non-small cell lung cancer (NSCLC) presented the edema typically localized in the lower eyelid after first-line treatment with carboplatin-pemetrexed. The edema remained identical in both patients during treatment and regressed in one patient in whom treatment was withdrawn. No other localizations of edema were observed in these patients.
  
  
  CONCLUSIONS
  Pemetrexed-induced eyelid edema may be more frequent than originally reported. The physiopathological mechanism and, as a consequence, the treatment and/or prevention of this apparently benign side-effect remains unknown.
authors.affiliation: Department of Medical Oncology, Oncologisch Centrum, UZ Brussel, 1090 Brussels, Belgium. denis.schallier@uzbrussel.be
authors.forename: D
authors.initials: D
authors.lastname: Schallier
authors.forename: L
authors.initials: L
authors.lastname: Decoster
authors.forename: C
authors.initials: C
authors.lastname: Fontaine
authors.forename: J
authors.initials: J
authors.lastname: De Grève
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced*; D005141:Eyelid Diseases / Q000139:chemically induced*; D005143:Eyelids / Q000187:drug effects; D005260:Female; D005971:Glutamates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006147:Guanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy; D008875:Middle Aged; D000068437:Pemetrexed; D012189:Retrospective Studies
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D016190:Carboplatin