title: Preparation of magnetic microspheres based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) copolymers by modified solvent diffusion method.
abstract: Magnetic microspheres have promising application in biomedical field. In this paper, biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) triblock copolymers were synthesized by ring-opening polymerization method. Through adjusting the epsilon-CL/PEG weight ratio in feed, PCEC copolymers with different block ratio were obtained. A novel modified solvent diffusion method was described to prepare magnetic PCEC composite microspheres containing magnetite nanoparticles. The particle size of microsphere decreased with increase in the PEG/PCL block ratio. The obtained microspheres could response to external magnetic field. This study described a novel method to prepare magnetic microspheres. The obtained magnetic polymeric microspheres might have potential application in drug delivery system or disease diagnosis field.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Men
authors.forename: Shi
authors.initials: S
authors.lastname: Zeng
authors.forename: MaLing
authors.initials: M
authors.lastname: Gou
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Ying Chun
authors.initials: YC
authors.lastname: Gu
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: YuQuan
authors.initials: Y
authors.lastname: Wei
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D004058:Diffusion; D005026:Ethylene Glycols / Q000737:chemistry*; D018189:Immunomagnetic Separation; D008280:Magnetics; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D005026:Ethylene Glycols; D011091:Polyesters; D011108:Polymers; D012997:Solvents; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol)