title: Many routes to the same destination: lessons from skeletal muscle development.
abstract: The development and differentiation of vertebrate skeletal muscle provide an important paradigm to understand the inductive signals and molecular events controlling differentiation of specific cell types. Recent findings show that a core transcriptional network, initiated by the myogenic regulatory factors (MRFs; MYF5, MYOD, myogenin and MRF4), is activated by separate populations of cells in embryos in response to various signalling pathways. This review will highlight how cells from multiple distinct starting points can converge on a common set of regulators to generate skeletal muscle.
authors.affiliation: Division of Animal Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK.
authors.forename: Gi Fay
authors.initials: GF
authors.lastname: Mok
authors.forename: Dylan
authors.initials: D
authors.lastname: Sweetman
mesh_terms: D000818:Animals; D005121:Extremities / Q000196:embryology; D053263:Gene Regulatory Networks / Q000502:physiology*; D006257:Head / Q000196:embryology; D006801:Humans; D008954:Models, Biological; D024510:Muscle Development / Q000235:genetics / Q000502:physiology*; D018482:Muscle, Skeletal / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism*; D009333:Neck / Q000196:embryology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology / Q000378:metabolism