title: 1H, 13C and 15N assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis.
abstract: GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N. meningitidis. Here we report almost complete (1)H, (13)C and (15)N resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution.
authors.affiliation: Bijvoet Center for Biomolecular Research, Science Faculty, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Neumoin
authors.forename: A
authors.initials: A
authors.lastname: Leonchiks
authors.forename: P
authors.initials: P
authors.lastname: Petit
authors.forename: L
authors.initials: L
authors.lastname: Vuillard
authors.forename: M
authors.initials: M
authors.lastname: Pizza
authors.forename: M
authors.initials: M
authors.lastname: Soriani
authors.forename: R
authors.initials: R
authors.lastname: Boelens
authors.forename: A M J J
authors.initials: AM
authors.lastname: Bonvin
mesh_terms: D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000737:chemistry*; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry*; D002247:Carbon Isotopes; D008074:Lipoproteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D009345:Neisseria meningitidis; D009587:Nitrogen Isotopes; D011994:Recombinant Proteins / Q000737:chemistry; D016415:Sequence Alignment
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002247:Carbon Isotopes; D008074:Lipoproteins; D009587:Nitrogen Isotopes; D011994:Recombinant Proteins