title: Osmium(VI) complexes as a new class of potential anti-cancer agents.
abstract: A nitridoosmium(VI) complex [Os(VI)(N)(sap)(OH(2))Cl] (H(2)sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5'-guanosine monophosphate.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong, China.
authors.forename: Wen-Xiu
authors.initials: WX
authors.lastname: Ni
authors.forename: Wai-Lun
authors.initials: WL
authors.lastname: Man
authors.forename: Myra Ting-Wai
authors.initials: MT
authors.lastname: Cheung
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Yuan-Lan
authors.initials: YL
authors.lastname: Shu
authors.forename: Yun-Wah
authors.initials: YW
authors.lastname: Lam
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
authors.forename: Tai-Chu
authors.initials: TC
authors.lastname: Lau
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D017892:Osmium Compounds / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D017892:Osmium Compounds