title: Expression of the Forkhead transcription factor FOXP1 is associated with tumor grade and Ki67 expression in clear cell renal cell carcinoma.
abstract: Expression of FOXP1 and Ki67 was immunohistochemically assessed on tissue microarrays of 129 cases of clear cell renal cell carcinomas. Overall and disease-specific survival correlated inversely with pT-category, grading and lymph node metastasis in (p < .05). Expression of FOXP1 correlated negatively with tumor grading (p = .02), but neither with pT-category nor with lymph node metastasis. Significant positive correlation was shown for Ki67 expression and tumor stage and lymph node metastasis (p < .05). The overall survival and the disease-specific survival correlated negatively with the Ki67 status (p < .05). FOXP1 expression negatively correlated with Ki67 expression in clear cell renal cell carcinomas (p = .036).
authors.affiliation: Institute of Pathology, Medicine University Carl Gustav Carus, Technical University of Dresden, Dresden, Germany. marieta.toma@uniklinikum-dresden.de
authors.forename: Marieta I
authors.initials: MI
authors.lastname: Toma
authors.forename: Thomas
authors.initials: T
authors.lastname: Weber
authors.forename: Matthias
authors.initials: M
authors.lastname: Meinhardt
authors.forename: Stefan
authors.initials: S
authors.lastname: Zastrow
authors.forename: Marc-Oliver
authors.initials: MO
authors.lastname: Grimm
authors.forename: Susanne
authors.initials: S
authors.lastname: Füssel
authors.forename: Manfred P
authors.initials: MP
authors.lastname: Wirth
authors.forename: Gustavo B
authors.initials: GB
authors.lastname: Baretton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D051858:Forkhead Transcription Factors / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D007680:Kidney Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D012097:Repressor Proteins / Q000032:analysis*
chemical_list: C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D019394:Ki-67 Antigen; D012097:Repressor Proteins