title: Assessing spatiotemporal patterns of multidrug-resistant and drug-sensitive tuberculosis in a South American setting.
abstract: We examined the spatiotemporal distribution of laboratory-confirmed multidrug-resistant tuberculosis (MDR TB) cases and that of other TB cases in Lima, Peru with the aim of identifying mechanisms responsible for the rise of MDR TB in an urban setting. All incident cases of TB in two districts of Lima, Peru during 2005-2007 were included. The spatiotemporal distributions of MDR cases and other TB cases were compared with Ripley's K statistic. Of 11,711 notified cases, 1187 received drug susceptibility testing and 376 were found to be MDR. Spatial aggregation of patients with confirmed MDR disease appeared similar to that of other patients in 2005 and 2006; however, in 2007, cases with confirmed MDR disease were found to be more tightly grouped. Subgroup analysis suggests the appearance of resistance may be driven by increased transmission. Interventions should aim to reduce the infectious duration for those with drug-resistant disease and improve infection control.
authors.affiliation: Division of Global Health Equity, Brigham and Women's Hospital, Boston, USA.
authors.forename: H
authors.initials: H
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Shin
authors.forename: J A
authors.initials: JA
authors.lastname: Blaya
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Cegielski
authors.forename: C
authors.initials: C
authors.lastname: Contreras
authors.forename: L
authors.initials: L
authors.lastname: Asencios
authors.forename: C
authors.initials: C
authors.lastname: Bonilla
authors.forename: J
authors.initials: J
authors.lastname: Bayona
authors.forename: C J
authors.initials: CJ
authors.lastname: Paciorek
authors.forename: T
authors.initials: T
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D040362:Geographic Information Systems; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010568:Peru / Q000453:epidemiology; D012189:Retrospective Studies; D014376:Tuberculosis / Q000145:classification / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission
chemical_list: D000995:Antitubercular Agents