title: New diketopiperazine derivatives isolated from sea urchin-derived bacillus sp.
abstract: Two new diketopiperazine derivatives, bacillusamides A (1) and B (2), have been isolated from the EtOAc extract of the sea urchin-derived Bacillus sp. along with the known cyclo(-L-pro-L-val-) (3), cyclo(-L-pro-L-tyr-) (4), cyclo(-L-pro-L-phe-) (5). These structures were elucidated by extensive spectroscopic methods. Furthermore, the absolute configurations of the amino acid residues were determined using Marfey's method. Compound 1 displayed weak antifungal activity against Aspergillus niger.
authors.affiliation: Garden for Medicinal Plants, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyou-machi, Nagasaki, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yonezawa
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.forename: Isao
authors.initials: I
authors.lastname: Kouno
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001407:Bacillus / Q000737:chemistry*; D054659:Diketopiperazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012617:Sea Urchins / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D054659:Diketopiperazines; C557630:bacillusamide A; C557629:bacillusamide B