title: Role of the nuclear lamina in genome organization and gene expression.
abstract: The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and have a role in gene regulation. Recent genome-wide mapping studies and functional experimental data strongly support these roles of the nuclear lamina. Here, we discuss new insights into various aspects of genome-nuclear lamina interactions, with emphasis on the links with gene regulation and with dynamics during cellular differentiation.
authors.affiliation: Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Peric-Hupkes
authors.forename: B
authors.initials: B
authors.lastname: van Steensel
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D002874:Chromosome Mapping; D047108:Embryonic Development / Q000235:genetics; D005786:Gene Expression Regulation; D020868:Gene Silencing; D016678:Genome / Q000235:genetics*; D006801:Humans; D034882:Lamins / Q000378:metabolism; D008954:Models, Biological; D034881:Nuclear Lamina / Q000235:genetics*; D022022:Nuclear Pore / Q000378:metabolism; D011485:Protein Binding; D013269:Stochastic Processes
chemical_list: D002843:Chromatin; D034882:Lamins