title: [Brain-derived neurotrophic factor (BDNF) and mood disorder].
abstract: Brain-derived neurotrophic factor (BDNF) is the most abundant and widely expressed neurotrophin in the brain. BDNF is believed to play an important role in depressive disorder. Chronic stress decreases the synthesis of hippocampal BDNF, which leads to atrophy of the hippocampus in the depressed patients. Blood BDNF levels also decreased in depressed patients and a correlation is observed between severities of depressive state and blood BDNF levels. Selective serotonin reuptake inhibitors and serotonin noradrenalin reuptake inhibitors both recover the decreased blood BDNF levels. These findings indicate that the blood BDNF level is one of the candidate biomarkers for depression.
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, 11 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. yoshi621@med.uoeh-u.ac.jp
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ikenouchi-Sugita
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene-Nakano
authors.forename: Asuka
authors.initials: A
authors.lastname: Katsuki
authors.forename: Kenji
authors.initials: K
authors.lastname: Hayashi
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Atake
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ueda
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D001284:Atrophy; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D019964:Mood Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D055495:Neurogenesis; D009473:Neuronal Plasticity; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012720:Severity of Illness Index; D013569:Synapses / Q000502:physiology
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D017367:Selective Serotonin Reuptake Inhibitors