title: Isolation and complete nucleotide sequence of the measles virus IMB-1 strain in China.
abstract: The complete nucleotide sequence of the measles virus strain IMB-1, which was isolated in China, was determined. As in other measles viruses, its genome is 15,894 nucleotides in length and encodes six proteins. The full-length nucleotide sequence of the IMB-1 isolate differed from vaccine strains (including wild-type Edmonston strain) by 4%-5% at the nucleotide sequence level. This isolate has amino acid variations over the full genome, including in the hemagglutinin and fusion genes. This report is the first to describe the full-length genome of a genotype H1 strain and provide an overview of the diversity of genetic characteristics of a circulating measles virus.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
authors.forename: Shao-hui
authors.initials: SH
authors.lastname: Ma
authors.forename: Li-chun
authors.initials: LC
authors.lastname: Wang
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Liu
authors.forename: Hai-jing
authors.initials: HJ
authors.lastname: Shi
authors.forename: Long-ding
authors.initials: LD
authors.lastname: Liu
authors.forename: Qi-han
authors.initials: QH
authors.lastname: Li
mesh_terms: D019943:Amino Acid Substitution; D001483:Base Sequence; D002648:Child; D002681:China; D005260:Female; D016679:Genome, Viral; D006801:Humans; D008457:Measles / Q000821:virology; D008459:Measles virus / Q000235:genetics* / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins