title: Decreased susceptibility to ciprofloxacin among Shigella isolates in the United States, 2006 to 2009.
abstract: We characterized 20 Shigella isolates with decreased susceptibility to fluoroquinolones. Most patients (80%) from whom a travel history was obtained reported travel to South or Southeast Asia. Mutations within the quinolone resistance determining regions of gyrA and parC and plasmid-mediated resistance determinants (qnrB, qnrS, and aac(6')-Ib-cr) were identified. The rise in antimicrobial resistance among Shigella isolates may necessitate the increased use of extended-spectrum cephalosporins or macrolides in some patients.
authors.affiliation: Division of Foodborne, Waterborne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. gux8@cdc.gov
authors.forename: Jason P
authors.initials: JP
authors.lastname: Folster
authors.forename: Gary
authors.initials: G
authors.lastname: Pecic
authors.forename: Anna
authors.initials: A
authors.lastname: Bowen
authors.forename: Regan
authors.initials: R
authors.lastname: Rickert
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
authors.forename: Jean M
authors.initials: JM
authors.lastname: Whichard
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology; D018942:Macrolides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D012760:Shigella / Q000187:drug effects* / Q000235:genetics; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D018942:Macrolides; D002939:Ciprofloxacin