title: Current progress in pharmacogenetics.
abstract: The study of genetic variation has the potential to aid understanding of the mechanisms underlying the observed inter-individual variation in drug response and by which idiosyncratic adverse effects occur. In this review, we outline current progress in pharmacogenetics using examples to highlight both mechanisms of influence of polymorphisms and research strategies for their detection. In the final sections we discuss contemporary challenges for both researchers and clinicians.
authors.affiliation: Respiratory Biomedical Research Unit, City Hospital Campus, Nottingham, UK. john.blakey@nottingham.ac.uk
authors.forename: John D
authors.initials: JD
authors.lastname: Blakey
authors.forename: Ian P
authors.initials: IP
authors.lastname: Hall
mesh_terms: D015195:Drug Design; D005786:Gene Expression Regulation / Q000187:drug effects*; D014644:Genetic Variation / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D004364:Pharmaceutical Preparations