title: Cryopreservation of ovarian tissue for fertility preservation: no evidence of malignant cell contamination in ovarian tissue from patients with breast cancer.
abstract: Cryopreserved ovarian cortical biopsies from 51 patients with breast cancer were examined by histologic and immunohistochemical analysis and showed no sign of metastases. Autotransplantation of ovarian cortex to patients with low-stage breast cancer disease appears safe, but confirmatory studies are required, including xenotransplantation studies.
authors.affiliation: Laboratory of Reproductive Biology, Copenhagen University Hospital, and The Fertility Clinic, Copenhagen University, Copenhagen, Denmark. mikro@dadlnet.dk
authors.forename: Mikkel
authors.initials: M
authors.lastname: Rosendahl
authors.forename: Vera
authors.initials: V
authors.lastname: Timmermans Wielenga
authors.forename: Lotte
authors.initials: L
authors.lastname: Nedergaard
authors.forename: Stine Gry
authors.initials: SG
authors.lastname: Kristensen
authors.forename: Erik
authors.initials: E
authors.lastname: Ernst
authors.forename: Per Emil
authors.initials: PE
authors.lastname: Rasmussen
authors.forename: Michael
authors.initials: M
authors.lastname: Anderson
authors.forename: Kirsten Tryde
authors.initials: KT
authors.lastname: Schmidt
authors.forename: Claus Yding
authors.initials: CY
authors.lastname: Andersen
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology*; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology*; D015925:Cryopreservation / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D005260:Female; D005298:Fertility / Q000502:physiology; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000517:prevention & control*; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000556:secondary*; D010053:Ovary; D011247:Pregnancy; D011309:Preservation, Biological / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data; D055815:Young Adult