title: [Present status on studies of differentiation into retinal neurons and pigmented cell from induced pluripotent stem cells].
abstract: Somatic cells could be induced into pluripotent stem (iPS) cells through transferring special genes (Oct4, Sox2, c-myc and Klf4). This has brought a revolutionary change in stem cell study and application. The generation of iPS cells has great potential and enormous significance as it can resolve some insurmountable problems in stem cells research, such as ethical dilemma, immune rejection, etc. Because of these characteristics, it plays an important role in the repair of various tissues and organs. Rapid progress in this field during the past 3 years convinced us that iPS cells will be more and more applicable in tissue engineering. The present paper reviews the progress of pre-clinical study on iPS cells in the treatment of retinal and optic nerve diseases.
authors.affiliation: Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
authors.forename: Feng-xi
authors.initials: FX
authors.lastname: Meng
authors.forename: Wen-yi
authors.initials: WY
authors.lastname: Guo
mesh_terms: D018929:Cell Culture Techniques; D002454:Cell Differentiation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D000090062:Kruppel-Like Factor 4; D010857:Pigment Epithelium of Eye / Q000166:cytology*; D055351:Retinal Neurons / Q000166:cytology*