title: Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer.
abstract: Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of (99m)Tc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in (99m)Tc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant. In contrast to immunohistochemical analysis, (99m)Tc-AnxV imaging could not be used to predict tumor response, due to large variation between animals.
authors.affiliation: Division of Diagnostic Oncology, Netherland Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Chantal A C
authors.initials: CA
authors.lastname: Beekman
authors.forename: Tessa
authors.initials: T
authors.lastname: Buckle
authors.forename: Anne C
authors.initials: AC
authors.lastname: van Leeuwen
authors.forename: Renato A
authors.initials: RA
authors.lastname: Valdés Olmos
authors.forename: Marcel
authors.initials: M
authors.lastname: Verheij
authors.forename: Sven
authors.initials: S
authors.lastname: Rottenberg
authors.forename: Fijs W B
authors.initials: FW
authors.lastname: van Leeuwen
mesh_terms: D000818:Animals; D017304:Annexin A5; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D004195:Disease Models, Animal; D000077143:Docetaxel; D051379:Mice; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D017304:Annexin A5; D015609:Organotechnetium Compounds; D043823:Taxoids; D000077143:Docetaxel