title: Ring B aromatic norpimarane glucoside from a Xylaria sp.
abstract: A novel 20-norpimarane glucoside, xylopimarane (1), together with the known sphaeropsidin C (2) and clonostachydiol (3), was isolated from the fungus Xylaria sp. BCC 4297. Compound 1 exhibited cytotoxicity to cancer cell lines KB, MCF-7, and NCI-H187 with respective IC(50) values of 1.0, 13, and 65 μM.
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand. isaka@biotec.or.th
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Arunrat
authors.initials: A
authors.lastname: Yangchum
authors.forename: Patchanee
authors.initials: P
authors.lastname: Auncharoen
authors.forename: Kitlada
authors.initials: K
authors.lastname: Srichomthong
authors.forename: Prasert
authors.initials: P
authors.lastname: Srikitikulchai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D013785:Thailand; D014709:Vero Cells; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D005960:Glucosides; D006027:Glycosides; C557519:xylopimarane