title: Nano-encapsulations liberated from barley protein microparticles for oral delivery of bioactive compounds.
abstract: Novel microparticles (3-5 μm) were created by pre-emulsifying barley proteins with a homogenizer followed a microfluidizer system. These microparticles exhibited a high oil carrying capacity (encapsulation efficiency, 93-97%; loading efficiency, 46-49%). Microparticle degradation and bioactive compound release behaviours were studied in the simulated gastro-intestinal (GI) tract. The data revealed that nano-encapsulations (20-30 nm) were formed as a result of enzymatic degradation of barley protein microparticle bulk matrix in the simulated gastric tract. These nano-encapsulations delivered β-carotene to a simulated human intestinal tract intact, where they were degraded by pancreatic enzymes and steadily released the β-carotene. These uniquely structured microparticles may provide a new strategy for the nutraceutical and pharmaceutical industries to develop targeted delivery systems for lipophilic bioactive compounds.
authors.affiliation: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.
authors.forename: Ruoxi
authors.initials: R
authors.lastname: Wang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Tian
authors.forename: Lingyun
authors.initials: L
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D004337:Drug Carriers / Q000737:chemistry* / Q000302:isolation & purification; D004339:Drug Compounding; D004591:Electrophoresis, Polyacrylamide Gel; D005750:Gastric Juice / Q000737:chemistry / Q000378:metabolism; D001467:Hordeum / Q000737:chemistry*; D006801:Humans; D007419:Intestinal Secretions / Q000737:chemistry / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D010940:Plant Proteins / Q000737:chemistry* / Q000302:isolation & purification; D013499:Surface Properties; D019207:beta Carotene / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004337:Drug Carriers; D010940:Plant Proteins; D019207:beta Carotene