title: [Comparative study on the effects of LEEP and laser CO(2) vaporization in cervical intraepithelial neoplasia II].
abstract: OBJECTIVE
  to compare the effect and complications of loop electro-surgical excision procedure (LEEP) and laser CO(2) vaporization in the treatment of cervical intraepithelial neoplasia II.
  
  
  METHODS
  a total of 338 CINII women were recruited into this multi-center comparative study. The diagnosis was confirmed by histopathological examination for cervical epithelial cell abnormalities. And colposcopic examination was submitted to LEEP (n = 195) or laser CO(2) vaporization (n = 143) respectively. A post-treatment follow-up of 3, 6 and 12 months was carried out to compare the effect of two methods.
  
  
  RESULTS
  among 195 women undergoing LEEP, the frequency of cure, persistent and recurrent CIN was 89.2% (n = 174), 4.1% (n = 8) and 3.6% (n = 7) respectively. And among 143 women receiving laser CO(2) vaporization, the frequency of cure, persistent and recurrent CIN was 86.7% (n = 124), 4.9% (n = 7) and 0.70% (n = 1) respectively. There was no statistical difference in cure rates, persistence or recurrence of CIN (P > 0.05). The recovery time, the operative frequency and intra-operative blood loss were significantly different in two groups.
  
  
  CONCLUSIONS
  both LEEP and CO(2) vaporization are both effective and reliable for the treatment of cervical intraepithelial neoplasia II. However, pathological specimens may be harvested during LEEP. It is of vital importance to conduct preoperative colposcopic assessment and standard postoperative follow-ups.
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Lu-Lu
authors.initials: LL
authors.lastname: Sun
authors.forename: Dong-Yan
authors.initials: DY
authors.lastname: Cao
authors.forename: Mei-Lu
authors.initials: ML
authors.lastname: Bian
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Wei
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Ning-Hai
authors.initials: NH
authors.lastname: Cheng
authors.forename: You-Fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Cheng
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Hu
authors.forename: Jing-He
authors.initials: JH
authors.lastname: Lang
authors.forename: Keng
authors.initials: K
authors.lastname: Shen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004598:Electrosurgery; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D014835:Volatilization; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*