title: [Inflammatory process in atherosclerosis].
abstract: Atherosclerosis is a chronic inflammatory disease. Development of atherosclerosis involves a variety of cell types, including endothelial, smooth muscle, and immune cells, which exhibit complex interplays. Recent studies have demonstrated that bone marrow-derived cells, including immune cells, play previously unappreciated roles in atherogenesis. In addition, it is becoming increasingly clear that chronic inflammation is also crucially involved in metabolic abnormalities, such as adipose tissue obesity and diabetes. Elucidation of molecular mechanisms that mediate cellular interactions in chronic inflammation would lead to identification of novel therapeutic targets.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Manabe
mesh_terms: D050197:Atherosclerosis / Q000209:etiology*; D002908:Chronic Disease; D048909:Diabetes Complications; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000209:etiology*; D024821:Metabolic Syndrome / Q000150:complications; D058990:Molecular Targeted Therapy; D056128:Obesity, Abdominal / Q000150:complications; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000473:pathology