title: HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.
abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine-induced SJS/TEN in Japanese.
authors.affiliation: Division of Medicinal Safety Sciences, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan. nkaniwa@nihs.go.jp
authors.forename: Nahoko
authors.initials: N
authors.lastname: Kaniwa
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Saito
authors.forename: Michiko
authors.initials: M
authors.lastname: Aihara
authors.forename: Kayoko
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tohkin
authors.forename: Kouichi
authors.initials: K
authors.lastname: Kurose
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Furuya
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Masamichi
authors.initials: M
authors.lastname: Abe
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ikeda
authors.forename: Mariko
authors.initials: M
authors.lastname: Kashiwagi
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Song
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ueta
authors.forename: Chie
authors.initials: C
authors.lastname: Sotozono
authors.forename: Zenro
authors.initials: Z
authors.lastname: Ikezawa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hasegawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005190:Family; D005260:Female; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D012307:Risk Factors; D013262:Stevens-Johnson Syndrome / Q000235:genetics*; D013785:Thailand
chemical_list: D015235:HLA-B Antigens; C483536:HLA-B*15:02 antigen; D059910:HLA-B15 Antigen; D002220:Carbamazepine