title: [Recurrent depression: episodes neurotoxicity and recurrences prevention].
abstract: Depression is a recurrent pathology with a self-induced vulnerability. To explain this spontaneous aggravation, we have been mainly focusing on the Kindling hypothesis. However, the kindling phenomenon only reflects the concept of vulnerability but omits explaining its mechanisms. Both data of imaging and clinical studies showed evidence that the length and the repetition of major depressive episodes increase the risk for more frequent new episodes, i.e. that depressive episodes could be neurotoxic per se. This neurotoxicity hypothesis of major depressive disorder, apart from allowing a different way of communicating with our patients and to facilitate their compliance, strengthen the necessity to prevent recurrent depressive episodes.
authors.affiliation: INSERM U894, Université Paris-Descartes, Centre de Psychiatrie et Neuroscience, CMME, Hôpital Sainte-Anne, Paris, France. p.gorwood@ch-sainte-anne.fr
authors.forename: P
authors.initials: P
authors.lastname: Gorwood
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D003142:Communication; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology* / Q000523:psychology; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology*; D008016:Life Change Events; D055118:Medication Adherence / Q000523:psychology; D010817:Physician-Patient Relations; D011594:Psychometrics; D012307:Risk Factors; D055502:Secondary Prevention; D014888:Wechsler Scales / Q000706:statistics & numerical data
chemical_list: D000928:Antidepressive Agents