title: The development of Th1-mediated sarcoidosis improves the clinical course of Th2-mediated atopic dermatitis.
abstract: Sarcoidosis is a chronic multisystem disease of unknown origin, which is characterized by T-helper-1 (Th1)-mediated immune responses. On the other hand, atopic dermatitis (AD) is characterized by Th2-mediated immune responses. We recently experienced an interesting case of AD in which the patient experienced a significant resolution of AD after the onset of sarcoidosis. We herein describe the details of his clinical course and discuss the impact of negative cross-regulation between Th1 and Th2 immune responses.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Miyagaki
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Sayaka
authors.initials: S
authors.lastname: Shibata
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ohno
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tsunemi
authors.forename: Hidehisa
authors.initials: H
authors.lastname: Saeki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D001706:Biopsy; D003876:Dermatitis, Atopic / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D012507:Sarcoidosis / Q000276:immunology / Q000503:physiopathology*; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology*; D014057:Tomography, X-Ray Computed
chemical_list: D011241:Prednisone