title: [A case successfully treated with subtotal esophagectomy after preoperative second-line chemotherapy for cT4 esophageal cancer].
abstract: A 69-year-old male was diagnosed with type 2 advanced esophageal cancer in the upper and middle thoracic esophagus which invaded the left main bronchus and the aorta. Radio-chemotherapy was administered since a radical resection could not be performed due to the invasion. Two courses of enforced FP combination therapy (5-FU and CDDP) were administered along with radiotherapy. Although this radio-chemotherapy was effective to some degree in tumor reduction, a radical resection still could not be performed due to the invasion of the left main bronchus and the aorta. Thus, we administered four more courses of DCF combination therapy (docetaxel, CDDP and 5-FU). This chemotherapy reduced the esophageal cancer mass significantly, and subtotal esophagectomy was performed. No complications were observed after the operation. We conclude that DCF combination therapy may be effective in the treatment of esophageal cancer in cases which the desired effect cannot be achieved by FP combination therapy alone.
authors.affiliation: Dept. of Surgery, Kyushu Central Hospital of Mutual Aid Association of Public School Teachers.
authors.forename: Takuya
authors.initials: T
authors.lastname: Honboh
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Mizuki
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hamatsu
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Akira
authors.initials: A
authors.lastname: Kabashima
authors.forename: Chie
authors.initials: C
authors.lastname: Ushijima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kitamura
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000628:therapy*; D016629:Esophagectomy / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil