title: Ascending thoracic aorta dimension and outcomes in acute type B dissection (from the International Registry of Acute Aortic Dissection [IRAD]).
abstract: It is not well known if the size of the ascending thoracic aorta at presentation predicts features of presentation, management, and outcomes in patients with acute type B aortic dissection. The International Registry of Acute Aortic Dissection (IRAD) database was queried for all patients with acute type B dissection who had documentation of ascending thoracic aortic size at time of presentation. Patients were categorized according to ascending thoracic aortic diameters ≤4.0, 4.1 to 4.5, and ≥4.6 cm. Four hundred eighteen patients met inclusion criteria; 291 patients (69.6%) were men with a mean age of 63.2 ± 13.5 years. Ascending thoracic aortic diameter ≤4.0 cm was noted in 250 patients (59.8%), 4.1 to 4.5 cm in 105 patients (25.1%), and ≥4.6 cm in 63 patients (15.1%). Patients with an ascending thoracic aortic diameter ≥4.6 cm were more likely to be men (p = 0.01) and have Marfan syndrome (p <0.001) and known bicuspid aortic valve disease (p = 0.003). In patients with an ascending thoracic aorta ≥4.1 cm, there was an increased incidence of surgical intervention (p = 0.013). In those with an ascending thoracic aorta ≥4.6 cm, the root, ascending aorta, arch, and aortic valve were more often involved in surgical repair. Patients with an ascending thoracic aorta ≤4.0 were more likely to have endovascular therapy than those with larger ascending thoracic aortas (p = 0.009). There was no difference in overall mortality or cause of death. In conclusion, ascending thoracic aortic enlargement in patients with acute type B aortic dissection is common. Although its presence does not appear to predict an increased risk of mortality, it is associated with more frequent open surgical intervention that often involves replacement of the proximal aorta. Those with smaller proximal aortas are more likely to receive endovascular therapy.
authors.affiliation: University of Michigan, Ann Arbor, USA. amanion@med.umich.edu
authors.forename: Anna M
authors.initials: AM
authors.lastname: Booher
authors.forename: Eric M
authors.initials: EM
authors.lastname: Isselbacher
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Nienaber
authors.forename: James B
authors.initials: JB
authors.lastname: Froehlich
authors.forename: Santi
authors.initials: S
authors.lastname: Trimarchi
authors.forename: Jeanna V
authors.initials: JV
authors.lastname: Cooper
authors.forename: Stefanos
authors.initials: S
authors.lastname: Demertzis
authors.forename: Vijay S
authors.initials: VS
authors.lastname: Ramanath
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Harris
authors.forename: Patrick T
authors.initials: PT
authors.lastname: O'Gara
authors.forename: Thoralf M
authors.initials: TM
authors.lastname: Sundt
authors.forename: Reed E
authors.initials: RE
authors.lastname: Pyeritz
authors.forename: Kim A
authors.initials: KA
authors.lastname: Eagle
mesh_terms: D000208:Acute Disease; D000784:Aortic Dissection / Q000175:diagnosis*; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000473:pathology; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis*; D017548:Echocardiography, Transesophageal; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed