title: [Randomly clinical study of ITP and NP regimens in the treatment of non-small cell lung cancer].
abstract: BACKGROUND
  To evaluate the efficacy and toxicity of ITP (ifosfamide + perarubicin + cisplatin) and NP (vinorelbine + cisplatin) regimens in the treatment of advanced non small cell lung cancer (NSCLC).
  
  
  METHODS
  One hundred inoperatable or recurrent patients with stage III and IV NSCLC were randomized into ITP group and NP group treated by the two regimens responsively for 2 or 3 cycles.
  
  
  RESULTS
  The overall response rate was 51.5% for ITP group and 50.9% for the NP group, respectively. There was no statistically significant difference of the overall response rate between the two groups ( P > 0.05). The major side effects were leukopenia and gastrointestinal reaction. The leukopenia incidence was higher in ITP group than that in NC group ( P < 0.05).
  
  
  CONCLUSIONS
  Both ITP and NP regimens are effective for the advanced NSCLC. Compared with ITP regimen, NP regimen has less bone marrow toxicity than ITP regimen.
authors.affiliation: Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yan
authors.forename: Mei
authors.initials: M
authors.lastname: Hou
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Gou