title: [Synthesis of 4-Chloro-6-(substituted-phenyl)-pyrimidines].
abstract: 4-Phenylamino-6-phenyl-pyrimidine is a common core structure of several, important enzyme inhibitors. The common key intermediate of these compounds, 4-chloro-6-substituted phenyl pyrimidine, was synthesised by conventional methods without the application of special catalysts in contrary to the published methods. Here we present two different synthetic procedures for the preparation of the title compound. The results of these processes depend on the substituent of the 6-phenyl ring as it is demonstrated on the presented examples. The reactions can be performed via traditional heating either with microwave assistance.
authors.affiliation: Racionális Hatóanyagtervezo Laboratórium, Kooperációs Kutató Központ, Semmelweis Egyetem, 1085, Budapest.
authors.forename: Gábor
authors.initials: G
authors.lastname: Németh
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Varga
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Greff
authors.forename: György
authors.initials: G
authors.lastname: Kéri
authors.forename: László
authors.initials: L
authors.lastname: Orfi
mesh_terms: D002712:Chlorides / Q000737:chemistry; D008872:Microwaves; D008958:Models, Molecular; D010636:Phenols / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D002712:Chlorides; D010636:Phenols; D011743:Pyrimidines