title: [In vitro maturation of oocytes: an option for fertility preservation in women].
abstract: Although female cancer incidence may be on rise, antineoplastic regimens have become more successful. As a result, an increasing number of women with cancer survive to endure the long-term consequences of chemotherapy. One of the most important long-term consequences of cancers treatments in young female is premature ovarian failure and infertility. Because of the increasing survival rates, many of these young women are seeking methods to preserve their fertility. Currently, embryo/oocytes cryoporeservation obtained after ovarian stimulation appears to provide the best fertility preservation option. However, patients may not have sufficient time to undergo ovarian stimulation prior to chemotherapy and/or the hormones used in ovarian stimulation are contra-indicated for estrogen-dependant tumors. In vitro maturation of oocytes (IVM) has been suggested to avoid ovarian stimulation and time requirement in patients with cancer, and can be combined with ovarian tissue cryobanking. In this review, we will discuss the position of IVM in the strategy of fertility preservation in young women.
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 157, rue de la Porte-de-Trivaux, 92141 Clamart, France. michael.grynberg@abc.aphp.fr
authors.forename: M
authors.initials: M
authors.lastname: Grynberg
authors.forename: L
authors.initials: L
authors.lastname: Hesters
authors.forename: J
authors.initials: J
authors.lastname: Bénard
authors.forename: R
authors.initials: R
authors.lastname: Trèves
authors.forename: R
authors.initials: R
authors.lastname: Fanchin
authors.forename: R
authors.initials: R
authors.lastname: Frydman
authors.forename: N
authors.initials: N
authors.lastname: Frydman
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D002478:Cells, Cultured; D015925:Cryopreservation; D004622:Embryo, Mammalian; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced; D009369:Neoplasms / Q000188:drug therapy*; D009865:Oocytes / Q000254:growth & development* / Q000502:physiology; D010053:Ovary; D011247:Pregnancy; D014015:Tissue Banks
chemical_list: D000970:Antineoplastic Agents