title: Comparison of compendial antimicrobial effectiveness tests: a review.
abstract: The antimicrobial effectiveness or preservative effectiveness test is described in the tripartite compendia for sterile parenteral multi-dose formulated products. The execution of the test is essentially harmonized with respect to inoculum preparation and test execution but not the acceptance criteria. This article describes how a single test can be performed that procedurally satisfies all of the compendia and their acceptance criteria.
authors.affiliation: Merck & Co., 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, USA.
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Moser
authors.forename: Brian K
authors.initials: BK
authors.lastname: Meyer
mesh_terms: D004340:Drug Contamination / Q000517:prevention & control*; D006801:Humans; D007263:Infusions, Parenteral; D004364:Pharmaceutical Preparations / Q000592:standards*; D010602:Pharmacopoeias as Topic; D011310:Preservatives, Pharmaceutical
chemical_list: D004364:Pharmaceutical Preparations; D011310:Preservatives, Pharmaceutical