title: Effect of maleic acid and ethylenediaminetetraacetic acid on the dissolution of human pulp tissue--an in vitro study.
abstract: OBJECTIVE
  To compare in vitro, the tissue-dissolution capacity of 7% maleic acid (MA), 17% ethylenediaminetetraacetic acid (EDTA), 2.5% sodium hypochlorite (NaOCl) (positive control) and 0.9% saline (NaCl) (negative control) on human pulp tissue.
  
  
  METHODS
  Forty pieces of human pulp tissue, each weighing 0.026 g, were divided randomly into four groups (n = 10): (i) 7% MA solution, (ii) 17% EDTA solution, (iii) 2.5% NaOCl solution and (iv) 0.9% NaCl solution. The pulp tissue was placed in beakers containing the test solutions and then placed on a vibrator. Pulp tissue from the four experimental solutions was blotted dry and weighed after 30, 60, 90 and 120 min. The percentage of weight loss was calculated, and the data were statistically analysed using Kruskal-Wallis and Mann-Whitney U-test.
  
  
  RESULTS
  At all time intervals, 2.5% NaOCl dissolved pulp tissue significantly more than the other solutions (P < 0.001). There was no significant difference in the pulp-dissolution capacity between 7% MA and 17% EDTA at any of the time intervals. NaCl (0.9%) did not have any effect on pulp tissue.
  
  
  CONCLUSIONS
  Seven percentage of MA and 17% EDTA had minimal tissue-dissolution capacity when compared to NaOCl.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Manipal College of Dental Sciences, Manipal, India. drballal@yahoo.com
authors.forename: N V
authors.initials: NV
authors.lastname: Ballal
authors.forename: K
authors.initials: K
authors.lastname: Mala
authors.forename: K S
authors.initials: KS
authors.lastname: Bhat
mesh_terms: D003782:Dental Pulp / Q000187:drug effects*; D004492:Edetic Acid / Q000494:pharmacology*; D006801:Humans; D008298:Maleates / Q000494:pharmacology*; D012388:Root Canal Irrigants / Q000494:pharmacology*; D012973:Sodium Hypochlorite / Q000494:pharmacology; D018709:Statistics, Nonparametric
chemical_list: D008298:Maleates; D012388:Root Canal Irrigants; C030272:maleic acid; D004492:Edetic Acid; D012973:Sodium Hypochlorite