title: [Chronic respiratory diseases and atherosclerosis].
abstract: Chronic respiratory diseases including chronic obstructive pulmonary disease (COPD) are recently recognized as systemic inflammatory disorders and considered to be a new risk factor for atherosclerosis. The increased serum levels of C-reactive protein, TNF, VEGF, IL-6, and ICAM-1 were known in patients with COPD. The accelerated pulse wave velocity(PWV) and the increased intima-media thickness of internal jugular artery were significantly found in the patients, when compared with the smokers without COPD. The anti-atherogenic agents including statins and ARBs are reported to be effective for the reduced mortality in the patients. The possibility of COPD as a novel atherogenic factor is discussed.
authors.affiliation: Department of Pulmonary Medicine, National Health Organization, Tokyo National Hospital.
authors.forename: Shinji
authors.initials: S
authors.lastname: Teramoto
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Akashi
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D050197:Atherosclerosis / Q000209:etiology* / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007249:Inflammation / Q000150:complications / Q000175:diagnosis; D018836:Inflammation Mediators / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011674:Pulse; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018836:Inflammation Mediators; D015850:Interleukin-6; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein