title: HLA-B*1502 genotyping in two Chinese patients with phenytoin-induced Stevens-Johnson syndrome.
abstract: Previous studies have reported that patients with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (PHT-induced SJS/TEN) were positive for HLA-B*1502. We genotyped two patients with PHT-induced SJS using both polymerase chain reaction with sequence-specific primers and sequencing. The results revealed that one patient from Henan Province had HLA-B*1501/B*5401, and the other patient from Guangdong Province had HLA-B*1502/B*4601. When this information was combined with the results from Taiwan and Hong Kong, a significant difference was observed in the presence of HLA-B*1502 between PHT-SJS and PHT-tolerant populations (35% vs 8%, P=0.001, OR=6.08, 95% CI=2.183-16.946). Additional studies in large samples are required to confirm the association between HLA-B*1502 and PHT-induced SJS/TEN.
authors.affiliation: Institute of Neuroscience and Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Fu-Li
authors.initials: FL
authors.lastname: Min
authors.forename: Yi-Wu
authors.initials: YW
authors.lastname: Shi
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Liu
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D044466:Asian People; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics; D015797:HLA-B35 Antigen; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*; D012640:Seizures / Q000188:drug therapy; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000235:genetics*
chemical_list: D000927:Anticonvulsants; D015235:HLA-B Antigens; C110012:HLA-B*35:43 antigen; D015797:HLA-B35 Antigen; D010672:Phenytoin