title: Internal Lewis acid assisted hydrogen bond donor catalysis.
abstract: Boronate ureas are introduced as a new class of noncovalent catalysts for conjugate addition reactions with enhanced activity. Through intramolecular coordination of the urea functionality to a strategically placed Lewis acid, rate enhancements up to 10 times that of more conventional urea catalysts are observed. The tunable nature of boronate ureas is a particularly attractive feature and enables the rational design of catalysts for optimal performance, in terms of both activity and stereocontrol, in new bond-forming processes.
authors.affiliation: Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
authors.forename: Sonia S
authors.initials: SS
authors.lastname: So
authors.forename: Julie A
authors.initials: JA
authors.lastname: Burkett
authors.forename: Anita E
authors.initials: AE
authors.lastname: Mattson