title: Predictive value of assessment of different modalities in the diagnosis of infantile cholestasis.
abstract: This study investigated the relative accuracy and roles of abdominal ultrasonography, hepatobiliary scintigraphy and liver biopsy in the diagnosis of infantile cholestasis. A total of 50 infants (27 females) aged 1 - 12 months were classified into those with intrahepatic causes of cholestasis (n = 22) and those with extrahepatic causes (n = 28). Cholestasis is caused by a wide range of conditions and diagnosis requires meticulous history taking, thorough clinical examination and many laboratory tests. The most common cause of intrahepatic cholestasis was found to be idiopathic neonatal hepatitis (54.5%), followed by infectious hepatitis (9.1%), metabolic liver diseases (9.1%), intrahepatic biliary atresia (9.1%) and Alagille syndrome (4.5%). The most common cause of extrahepatic cholestasis was extrahepatic biliary atresia (96.4%). The incidence of choledochal cyst was low (3.6%). The cornerstone of the diagnosis of infantile cholestasis was found to be liver biopsy, which was associated with a high degree of accuracy.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
authors.forename: A Es
authors.initials: AE
authors.lastname: Donia
authors.forename: S M
authors.initials: SM
authors.lastname: Ibrahim
authors.forename: M Sema
authors.initials: MS
authors.lastname: Kader
authors.forename: A M
authors.initials: AM
authors.lastname: Saleh
authors.forename: M S
authors.initials: MS
authors.lastname: El-Hakim
authors.forename: M S
authors.initials: MS
authors.lastname: El-Shorbagy
authors.forename: M M
authors.initials: MM
authors.lastname: Mansour
authors.forename: M A
authors.initials: MA
authors.lastname: Gibriel
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging; D001706:Biopsy; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003710:Demography; D005260:Female; D006801:Humans; D007098:Imino Acids; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008111:Liver Function Tests; D008297:Male; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D014463:Ultrasonography
chemical_list: D007098:Imino Acids; C008109:iminodiacetic acid