title: Lactic acidosis after resuscitation with sodium acetate.
abstract: BACKGROUND
  At our institution, we began using sodium acetate for resuscitation of trauma patients in 2005. Sodium acetate is used as an alternative to normal saline to help prevent hyperchloremic metabolic acidosis as well as to help buffer metabolic acidosis.
  
  
  CONCLUSIONS
  Here we present a case of a 29-year-old trauma patient who began to have severe lactic acidosis after the infusion of sodium acetate. This is the first reported case of lactic acidosis caused by sodium acetate infusion. Up to this point, we have not experienced any adverse events and patients have tolerated sodium acetate well.
  
  
  CONCLUSIONS
  This unique case report presents the first case of lactic acidosis from sodium acetate infusion. The lactic acidosis seen in this patient reminds us of the complex regulation of pyruvate dehydrogenase and the potential for down regulation of the enzyme shunting substrates to formation of lactate.
authors.affiliation: Department of Surgery, Arrowhead Regional Medical Center, Colton, California 92324-1819, USA. amccague@comcast.net
authors.forename: Andrew
authors.initials: A
authors.lastname: McCague
authors.forename: Nina
authors.initials: N
authors.lastname: Bowman
authors.forename: David T
authors.initials: DT
authors.lastname: Wong
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D000328:Adult; D006801:Humans; D008297:Male; D012151:Resuscitation / Q000009:adverse effects*; D019346:Sodium Acetate / Q000009:adverse effects*
chemical_list: D019346:Sodium Acetate