title: Peri-operative anaphylaxis.
abstract: Peri-operative anaphylaxis is an important cause for mortality and morbidity associated with anaesthesia. The true incidence is unknown and is most likely under reported. Diagnosis can be difficult, particularly as a number of drugs are given simultaneously and any of these agents can potentially cause anaphylaxis. This review covers the clinical features, differential diagnosis and management of anaphylaxis associated with anaesthesia. The investigations to confirm the clinical suspicion of anaphylaxis and further tests to identify the likely drug(s) are examined. Finally the salient features of common and rare causes including non-drug substances are described.
authors.affiliation: Department of Anaesthetics, Southampton University Hospitals NHS Trust, Tremona Road, Southampton, United Kingdom.
authors.forename: Linda
authors.initials: L
authors.lastname: Nel
authors.forename: Efrem
authors.initials: E
authors.lastname: Eren
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis* / Q000628:therapy; D000758:Anesthesia / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced / Q000175:diagnosis* / Q000628:therapy; D011183:Postoperative Complications / Q000139:chemically induced / Q000175:diagnosis* / Q000628:therapy; D009626:Terminology as Topic