title: An initial study of three-dimensional perfused blood volume computed tomography imaging of patients with anterior circulation hyperacute cerebral infarction.
abstract: OBJECTIVE
  To evaluate the value of three-dimensional (3D) whole brain perfused volume computed tomography (3D PBV CT) based on CT angiography (CTA) data in patients with hyperacute cerebral infarction.
  
  
  METHODS
  Thirty-five patients who had suffered stroke with anterior circulation within 3 hours underwent nonenhanced CT (NECT) scanning and CTA. Neuro PBV, a 3D software, was utilized to process the raw CTA data and a PBV image of the brain was obtained. Magnetic resonance imaging (MRI) was performed 6 hours after CT imaging. The volume and quantity of the ischemic lesion on 3D PBV and NECT were compared with MR-diffuse-weighted imaging (DWI).
  
  
  RESULTS
  The numbers of cerebral infarcts detected by MRI, PBV, and NECT were 40, 38 and 16, respectively. The results of kappa analysis between NECT and PBV with MR were -.0128 and .7622, and a paired t-test analysis for the measurement of infarct volume between PBV and MRI was t = 7.249, P > .05. The lesions that were not detected by PBV volumes less than 4.5 cm(3).
  
  
  CONCLUSIONS
  3D PBV CT has the potential to assess the full extent of an ischemic stroke at an early stage, whereas PBV is limited to the detection of small infarcts. The 3D PBV CT technique based on CTA data requires no additional radiation exposure or contrast medium injection, and can be performed in a short period of time.
authors.affiliation: Department of Radiology, the 85th Hospital of PLA, Shanghai 200052, China. zhuhaiyunxp@gmail.com
authors.forename: Hai-Yun
authors.initials: HY
authors.lastname: Zhu
authors.forename: Dao-Ying
authors.initials: DY
authors.lastname: Geng
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Geng
authors.forename: Dao-Ming
authors.initials: DM
authors.lastname: Wei
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D020520:Brain Infarction / Q000000981:diagnostic imaging* / Q000473:pathology; D002533:Cerebral Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging* / Q000473:pathology