title: Hyaluronidase inhibitory rosmarinic acid derivatives from Meehania urticifolia.
abstract: Nine new phenylpropanoids, rashomonic acids A-D (1-4) and meehaniosides A-E (5-9), along with four known compounds were isolated from Meehania urticifolia. The structure of each new compound was elucidated based on the results of spectroscopic analyses. Compounds 3-8 showed moderate hyaluronidase inhibitory activity with IC(50) values of 183-1049 µM.
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, Aoba-ku, Sendai, Japan. murata-t@tohoku-pharm.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D002934:Cinnamates / Q000737:chemistry* / Q000302:isolation & purification; D053630:Depsides / Q000737:chemistry* / Q000302:isolation & purification; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D000097123:Rosmarinic Acid
chemical_list: D002934:Cinnamates; D053630:Depsides; D006821:Hyaluronoglucosaminidase; D000097123:Rosmarinic Acid