title: Prostate tumour volume is an independent predictor of early biochemical recurrence in a high risk radical prostatectomy subgroup.
abstract: OBJECTIVE
  To assess if accurately determined tumour volume variables could serve as independent predictors of early biochemical recurrence in high risk prostate cancer patients who underwent radical prostatectomy.
  
  
  METHODS
  Tumour volume variables were calculated by digital planimetry in 269 prostatectomy specimens of patients with high risk prostate cancer. The associations to biochemical progression of tumour volume and clinicopathological variables, including age, pre-operative prostate specific antigen (PSA) levels, final Gleason score, pathological T stage, and surgical margins, were examined using univariate and multivariate Cox proportional hazards analyses.
  
  
  RESULTS
  Median tumour volume was 3.7 ml [interquartile range (IQR) 2.1-6.1 mL] and median follow-up time was 12 months (IQR 6-24 months). Biochemical recurrence occurred in 64 men (24%) during this period, with a median time to recurrence of 7.5 months (IQR 3.0-15.5 months). On univariate analysis all of the tumour volume variables were strongly correlated with the clinicopathological variables, as well as biochemical recurrence (p < 0.001). On multivariate analysis, we found that tumour volume variables served as independent predictors of PSA progression whilst other routinely reported pathological variables did not.
  
  
  CONCLUSIONS
  Accurately assessing tumour volume in the high risk setting may aid in identifying patients at greatest risk of developing early biochemical recurrence and most in need of adjuvant therapy.
authors.affiliation: Division of Urology, Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia. m.k.hong@ausdoctors.net
authors.forename: Matthew K H
authors.initials: MK
authors.lastname: Hong
authors.forename: Benjamin
authors.initials: B
authors.lastname: Namdarian
authors.forename: Niall M
authors.initials: NM
authors.lastname: Corcoran
authors.forename: John
authors.initials: J
authors.lastname: Pedersen
authors.forename: Declan G
authors.initials: DG
authors.lastname: Murphy
authors.forename: Justin S
authors.initials: JS
authors.lastname: Peters
authors.forename: Laurence
authors.initials: L
authors.lastname: Harewood
authors.forename: Nikhil
authors.initials: N
authors.lastname: Sapre
authors.forename: Kathryn
authors.initials: K
authors.lastname: Rzetelski-West
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Costello
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Hovens
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000401:mortality / Q000473:pathology*; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies