title: Flavonoid glycosides from Chromolaena odorata leaves and their in vitro cytotoxic activity.
abstract: Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3-13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC(50) values of 28.2 and 11.6 µM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC(50) value of 10.8 µM.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea. tmhung1810@yahoo.com
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: To Dao
authors.initials: TD
authors.lastname: Cuong
authors.forename: Nguyen Hai
authors.initials: NH
authors.lastname: Dang
authors.forename: Shu
authors.initials: S
authors.lastname: Zhu
authors.forename: Pham Quoc
authors.initials: PQ
authors.lastname: Long
authors.forename: Katsuko
authors.initials: K
authors.lastname: Komatsu
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D036604:Chromolaena / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D006027:Glycosides