title: From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase.
abstract: Central nervous system myelination requires recognition and signalling processes between neuronal axons and oligodendrocytes. Complex cellular rearrangements occur in myelination-competent oligodendrocytes requiring spatio-temporal control mechanisms. Although the molecular repertoire is becoming increasingly transparent, the signalling mechanisms governing myelination initiation are only poorly understood. The non-receptor tyrosine kinase Fyn has been implicated in axon-glial signal transduction and in several cellular processes required for oligodendrocyte maturation and myelination. Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon-glia interaction mediating myelination.
authors.affiliation: Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, Bentzelweg 3, Mainz, Germany. emkraemer@uni-mainz.de
authors.forename: Eva-Maria
authors.initials: EM
authors.lastname: Krämer-Albers
authors.forename: Robin
authors.initials: R
authors.lastname: White
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism; D009836:Oligodendroglia / Q000201:enzymology* / Q000378:metabolism; D051076:Proto-Oncogene Proteins c-fyn / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D051076:Proto-Oncogene Proteins c-fyn