title: ["Warming yang with pungent and sweet nature" compatibility of Guizhigancao Decoction].
abstract: OBJECTIVE
  To investigate the pharmacodynamic action and the mechanism of the compatibility of "warming yang with pungent and sweet nature" function in Guizhigancao Decoction.
  
  
  METHODS
  SD rats were divided randomly into four groups:normal control group, guizhi group, gancao group, and guzhi-gancao group. The function of platelet aggregation and release, the contents of 6-keto-PEG1alpha, TXB, cAMP, cGMP and dissociative calcium ion were detected to verify the effects.
  
  
  RESULTS
  Guzhi-gancao group had obvious effects on inducing platelet aggregationby inhibiting ADP, decreasing both wet weight and dry weight of thrombus in vitro, increasing thrombosis and the contents of 6-keto-PEG1alpha and decreasing concentrations of cGMP and calcium ion.
  
  
  CONCLUSIONS
  Compatibility of Guizhigancao Decoction can enhance the function of invigoration pulse beat through "warming yang with pungent and sweet nature".
authors.affiliation: Nanfang Hospital, Guangzhou 510515, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lv
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D027424:Cinnamomum / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry; D008297:Male; D008516:Medicine, Chinese Traditional; D010974:Platelet Aggregation / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D002118:Calcium