title: [Effect of hypoxia on activity of hypothalamo-pituitary- adrenal-cortex axis in rat].
abstract: OBJECTIVE
  In this experiment we used the methods of simulated hypoxia in a low-pressure cabin and RIA to investigate the effect of hypoxia on secretion of corticotropin-releasing factor (CRF) from hypothalamus and corticosterone from adrenal-cortex. And compare the effects of hypoxia on secretion of CRF and corticosterone in rat exposed to hypoxia for different time.
  
  
  RESULTS
  During acute hypoxia the secretion of CRF and level of plasma corticosterone rose significantly comparing with control. After 5 days of exposed to hypoxia the augment of secretion of CRF and level of plasma corticosterone decreased and to 15 days exposed to hypoxia the secretion of CRF and level of plasma corticosterone approached to control.
  
  
  CONCLUSIONS
  Hypoxia (2 h, 24 h) significantly activated HPA axis. After 5 days exposed to hypoxia the activity of HPA axis attenuated and began to recovery. After 15 days exposed to chronic hypoxia the activity of HPA axis has recovered to control level.
authors.affiliation: Department of Biological Technology, Zhejiang University, Hangzhou 310027, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: J Z
authors.initials: JZ
authors.lastname: Du
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone