title: Primary acantholytic squamous cell carcinoma of the cecum: a case report.
abstract: BACKGROUND
  Acantholytic squamous cell carcinoma (ASCC) is an uncommon histopathologic variant of SCC, characterized by marked acantholysis, wherein the tumor cells demonstrate defective cohesion to one another in the cancer nest leading to a pseudoglandular or pseudovascular appearance. The most common site of ASCC is the sun-exposed areas of the skin. Sporadic cases of ASCC have also been reported in various mucosal membranes and organs but to our knowledge this is the first case of primary ASCC of the large bowel.
  
  
  METHODS
  A 59-year-old woman underwent right hemicolectomy due to large tumor in cecum and initial part of the ascending colon. Microscopically, the tumor consisted of nests of focally keratinizing large, atypical, squamous epithelial cells. Approximately 70% of the tumor showed acantholytic changes and acantholysis was equally distributed through the entire tumor. Immunohistochemically tumor cells were diffusely positive for cytokeratin (CK) AE1/AE3 and focally positive for epithelial membrane antigen and syndecan 1. All other tested antibodies (CK7, CK 20, CK MNF116, E-cadherin, beta-catenin, p63, p16, CD31, CD34, CEA, estrogen, progesterone) showed negative reaction. Periodic acid Schiff and alcian blue staining showed no intracellular or extracellular mucinous material in the tumor. The diagnosis of acantholytic squamous cell carcinoma of the cecum was suspected and additional examination was recommended to exclude possibility of metastatic carcinoma. Extensive clinical examination which also included whole-body PET/CT scan showed no additional tumors. After the exclusion of possible metastatic disease the diagnosis of primary acantholytic squamous cell carcinoma of the cecum was confirmed. Six months after surgery the metastasis in small intestine and recurrence in the abdominal cavity at the site of surgery appeared and had the same morphological characteristic as the primary tumor in the cecum.
  
  
  CONCLUSIONS
  We report a unique case of ASCC arising in cecum and on this way expands the range of tumors originating in colon. Reports of more cases of colonic ASCC would possibly help to elucidate origin, clinical behavior and therapy of these tumors.
authors.affiliation: Department of Surgery, Nova Gradiska General Hospital, Croatia.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Jukić
authors.forename: Iva
authors.initials: I
authors.lastname: Ledinsky
authors.forename: Monika
authors.initials: M
authors.lastname: Ulamec
authors.forename: Mario
authors.initials: M
authors.lastname: Ledinsky
authors.forename: Božo
authors.initials: B
authors.lastname: Krušlin
authors.forename: Davor
authors.initials: D
authors.lastname: Tomas
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D002430:Cecal Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D003082:Colectomy; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D053667:Syndecans / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D018396:Mucin-1; D053667:Syndecans; D007633:Keratins