title: [Parameters of platelets activation and myeloperoxidase concentration as markers of coronary disease].
abstract: Ischemic heart disease is mainly caused by atherosclerosis and its complications. Platelets have important role in initiation of atherosclerotic lesions. Increase platelet activation and aggregation within coronary circulation initiate thrombus formation at a ruptured or eroded plaque. Large platelets are enzymatically and metabolically more active and have a higher potential thrombosis ability than smaller one. There is growing evidence that myocardial cell injury not only is related to platelet activation of neutrophils (PMNs). PMNs have been demonstrated to release myeloperoxidase (MPO) into coronary circulation. MPO promotes destabilization and rupture of the atherosclerotic plaque surface, impairing vasodilatory and anti-inflammatory function.
authors.affiliation: Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Hematologicznej.
authors.forename: Joanna
authors.initials: J
authors.lastname: Pawlus
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rusak
authors.forename: Joanna
authors.initials: J
authors.lastname: Chociej-Stypułkowska
authors.forename: Milena
authors.initials: M
authors.lastname: Dabrowska
mesh_terms: D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D009195:Peroxidase / Q000378:metabolism*; D015539:Platelet Activation
chemical_list: D015415:Biomarkers; D009195:Peroxidase