title: Are PON1 Q/R 192 and M/L 55 polymorphisms risk factors for diabetes complications in Turkish population?
abstract: OBJECTIVE
  We investigated whether the human serum paraoxonase (PON1) Q/R 192 and M/L 55 polymorphisms are associated with the complications of the type 2 diabetes (T2D).
  
  
  METHODS
  Study group was consisted of 50 healthy subjects and 100 type 2 diabetes mellitus (DM) patients. Following measuring of serum PON1 activity, isolation of DNA and genotyping analyses were performed.
  
  
  RESULTS
  PON1 activity of the patients with complications was significantly reduced by 23.5% compared to the group of diabetic patients and by 26.3% than the controls. According to multivariate analysis, we observed a three times significant effect of Q/R 192 polymorphism on the susceptibility to the occurrence of complications.
  
  
  CONCLUSIONS
  Protective effects of paraoxonase against peroxidation of LDL particles are important in T2D complications. Although both of the two polymorphisms are associated, 192 polymorphism seems to be stronger predictor of the risk of diabetic complications.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Toxicology, 06100, Tandogan, Ankara, Turkey.
authors.forename: Durdu
authors.initials: D
authors.lastname: Altuner
authors.forename: Sinan H
authors.initials: SH
authors.lastname: Suzen
authors.forename: Ilker
authors.initials: I
authors.lastname: Ates
authors.forename: Gonul V
authors.initials: GV
authors.lastname: Koc
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Aral
authors.forename: Asuman
authors.initials: A
authors.lastname: Karakaya
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D048909:Diabetes Complications / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014421:Turkey
chemical_list: D017931:DNA Primers; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human