title: Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease.
abstract: Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.
authors.affiliation: Department of Neurology, Washington University School of Medicine, 660 S, Euclid, Campus Box 8111, St Louis, MO 63110, USA. batemanr@wustl.edu.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Bateman
authors.forename: Paul S
authors.initials: PS
authors.lastname: Aisen
authors.forename: Bart
authors.initials: B
authors.lastname: De Strooper
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Lemere
authors.forename: John M
authors.initials: JM
authors.lastname: Ringman
authors.forename: Stephen
authors.initials: S
authors.lastname: Salloway
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.forename: Manfred
authors.initials: M
authors.lastname: Windisch
authors.forename: Chengjie
authors.initials: C
authors.lastname: Xiong