title: Path-length-resolved diffusive particle dynamics in spectral-domain optical coherence tomography.
abstract: We describe a new method to measure the decorrelation rate of the optical coherence tomography (OCT) magnitude simultaneously in space and time. We measure the decorrelation rate of the OCT magnitude in a Fourier-domain OCT system for a large range of translational diffusion coefficients by varying the sphere diameter. The described method uses the sensitivity advantage of Fourier-domain OCT over time-domain OCT to increase the particle diffusion imaging speed by a factor of 200. By coherent gating, we reduce the contribution of multiple scattering to the detected signal, allowing a quantitative study of diffusive particle dynamics in high concentration samples. We demonstrate that this technique is well suited to image diffusive particle dynamics in samples with a complex geometry as we measure the morphology and diffusive particle dynamics simultaneously with both high spatial and high temporal resolution.
authors.affiliation: Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands. j.kalkman@amc.nl
authors.forename: J
authors.initials: J
authors.lastname: Kalkman
authors.forename: R
authors.initials: R
authors.lastname: Sprik
authors.forename: T G
authors.initials: TG
authors.lastname: van Leeuwen
mesh_terms: D004058:Diffusion; D005583:Fourier Analysis; D008027:Light; D008962:Models, Theoretical; D012542:Scattering, Radiation; D013997:Time Factors; D041623:Tomography, Optical Coherence