title: Quantification of coronary stenosis by dual source computed tomography in patients: a comparative study with intravascular ultrasound and invasive angiography.
abstract: OBJECTIVE
  To determine the accuracy of dual-source CT (DSCT) to quantify coronary stenosis compared to intravascular ultrasound (IVUS) and quantitative coronary angiography (QCA).
  
  
  METHODS
  21 patients (23 vessels) were examined with DSCT, IVUS and invasive coronary angiography. Coronary minimal luminal diameter (MLD) and area (MLA) were measured in cross-sectional multi-planar reformatted images perpendicular to the vessel long-axis. The vessel cross-sectional area stenosis (MLA/CSA ratio) was calculated. DSCT results were compared with IVUS and QCA.
  
  
  RESULTS
  A good correlation between DSCT and IVUS was noted for diameter and area stenosis (r=0.69 and r=0.73), with an overestimation of MLD stenosis by DSCT (+9.1%) and an underestimation of MLA stenosis (-5.8%). For MLD and MLA, high correlation coefficients (r=0.78 and r=0.90, respectively) were found between DSCT and IVUS; and the bias was almost zero (-0.41 mm and +0.1mm(2), respectively). The correlation between DSCT and QCA was moderate (r=0.60) for MLD stenosis with minor overestimation by DSCT (+4.0%) and moderate (r=0.59) for MLD (bias, +0.01 mm). The cross-sectional area stenosis showed a moderate correlation (r=0.59) between DSCT and IVUS (+0.00).
  
  
  CONCLUSIONS
  DSCT allows accurate quantification of coronary stenosis as compared to IVUS. An excellent correlation was found for the MLA between DSCT and IVUS.
authors.affiliation: Massachusetts General Hospital-Harvard Medical School, Dept.Radiology, Boston, USA.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Feuchtner
authors.forename: Ricardo
authors.initials: R
authors.lastname: Loureiro
authors.forename: Hiram
authors.initials: H
authors.lastname: Bezerra
authors.forename: Jose A
authors.initials: JA
authors.lastname: Rocha-Filho
authors.forename: Ammar
authors.initials: A
authors.lastname: Sarwar
authors.forename: Tobias
authors.initials: T
authors.lastname: Pflederer
authors.forename: Mohamed
authors.initials: M
authors.lastname: Marwan
authors.forename: Milena
authors.initials: M
authors.lastname: Petranovic
authors.forename: Christopher O
authors.initials: CO
authors.lastname: Raffel
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Brady
authors.forename: Ik-Kyung
authors.initials: IK
authors.lastname: Jang
authors.forename: Stephan
authors.initials: S
authors.lastname: Achenbach
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cury
mesh_terms: D000465:Algorithms; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*