title: Inhibitory effect of hydrocortisone on cerebral salt wasting after subarachnoid hemorrhage in rats.
abstract: Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH). CSW induces excessive natriuresis and osmotic diuresis, reduces total blood volume, aggravates cerebral vasospasm and causes cerebral ischemia after SAH. This study examined the inhibitory effect of hydrocortisone on CSW in rat SAH models. Hydrocortisone had an inhibitory effect on CSW because hydrocortisone functioned in a dose-dependent manner to inhibit the increase in sodium excretion and sodium/potassium ratio after SAH onset. We conclude that hydrocortisone is a useful drug for the treatment of CSW after SAH.
authors.affiliation: Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. xza04623@nifty.com
authors.forename: M
authors.initials: M
authors.lastname: Yoneko
authors.forename: Y
authors.initials: Y
authors.lastname: Katayama
authors.forename: N
authors.initials: N
authors.lastname: Moro
authors.forename: J
authors.initials: J
authors.lastname: Kamei
authors.forename: J
authors.initials: J
authors.lastname: Kojima
mesh_terms: D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D009995:Osmosis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine*; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D020301:Vasospasm, Intracranial / Q000517:prevention & control
chemical_list: D012964:Sodium; D011188:Potassium; D006854:Hydrocortisone