title: Effects of serotonin transporter promoter and BDNF Val66Met genotype on personality traits in a population representative sample of adolescents.
abstract: The purpose of this study was to investigate the effects of the 5-HTTLPR and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms on self-reported Big Five personality traits and their facets in a population representative sample of adolescents. The sample consisted of both cohorts of the Estonian Children Personality Behaviour and Health Study, and personality data were collected during its second waves. The 5-HTTLPR and BDNF Val66Met polymorphisms were genotyped. The BDNF Val66Met had a significant effect on conscientiousness [F(1,807)=4.32, P=0.038]. We did not find effects of the 5-HTTLPR polymorphism on the main domains of personality, however, a gene×gene interaction on conscientiousness emerged -BDNF Val66Met Met-allele carriers with the 5-HTTLPR s/s genotype had by far the lowest scores in conscientiousness [F(2,803)=4.38, P=0.012]. In addition, we found genotype effects on some facet scales. In conclusion, the BDNF Val66Met genotype Met-allele carriers have lower conscientiousness, and this effect is increased in the 5-HTTLPR s/s individuals.
authors.affiliation: Departments of Psychology, University of Tartu, Estonia.
authors.forename: Kelli
authors.initials: K
authors.lastname: Hiio
authors.forename: Liis
authors.initials: L
authors.lastname: Merenäkk
authors.forename: Niklas
authors.initials: N
authors.lastname: Nordquist
authors.forename: Jüri
authors.initials: J
authors.lastname: Parik
authors.forename: Lars
authors.initials: L
authors.lastname: Oreland
authors.forename: Toomas
authors.initials: T
authors.lastname: Veidebaum
authors.forename: Jaanus
authors.initials: J
authors.lastname: Harro
mesh_terms: D000293:Adolescent; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D010551:Personality / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins