title: Expression of midkine and endoglin in breast carcinomas with different immunohistochemical profiles.
abstract: The aim of this study was to investigate the midkine and endoglin expression in breast carcinomas with five different immunohistochemical profiles and their relevance to histopathologic and clinicopathologic features. We analyzed 161 archival tissues immunohistologically. The level of midkine expression in breast cancer significantly correlated with lymph node metastasis (p = 0.001) and TNM staging (p = 0.003). High microvessel density (MVD) was associated with higher midkine reactivity group (p = 0.036). Although the basal-like subtype had higher midkine expression level and MVD, no significant difference with the other breast cancer subtypes was found. In conclusion, midkine was a promising target for tumor prognosis in clinical diagnosis and treatment. This study found no significant differences in tumor angiogenesis in different molecular subtypes of breast cancer.
authors.affiliation: Affiliated Central Hospital of Huzhou Teachers College, Zhejiang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qin Li
authors.forename: Hui Lian
authors.initials: HL
authors.lastname: Huang
authors.forename: Jin Liang
authors.initials: JL
authors.lastname: Ping
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Li Cheng
authors.initials: LC
authors.lastname: Dai
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis* / Q000502:physiology; D001943:Breast Neoplasms / Q000098:blood supply / Q000737:chemistry* / Q000145:classification / Q000473:pathology; D016207:Cytokines / Q000032:analysis* / Q000502:physiology; D000071063:Endoglin; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D000078792:Midkine; D009367:Neoplasm Staging; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000502:physiology
chemical_list: D015703:Antigens, CD; D016207:Cytokines; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D000078792:Midkine