title: Erbin, a negative regulator in diverse signal pathways.
abstract: Erbin belongs to the LAP protein family. It represents a novel type of adaptor protein that features targeting of basolateral localization of the Her2 receptor through direct binding to the Her2 C terminus. Recent studies demonstrated that Erbin could inhibit the Ras-mediated activation of the mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB) and transforming growth factor β (TGF-β) signaling pathways. It suggests that Erbin may function as a signaling molecule. The functions of Erbin in determining cell polarity and cell adhesion have been well described. This review mainly focuses on the recent findings in regulation of signaling pathways by Erbin.
authors.affiliation: Department of Pathology, Hebei Medical University, Shijiazhuang 050017, PR China.
authors.forename: Liu
authors.initials: L
authors.lastname: Dan
authors.forename: Ming
authors.initials: M
authors.lastname: Shi
authors.forename: Huijun
authors.initials: H
authors.lastname: Duan
authors.forename: Caili
authors.initials: C
authors.lastname: Han
authors.forename: Ning
authors.initials: N
authors.lastname: Guo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry* / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D016212:Transforming Growth Factor beta