title: The mammalian actin-binding protein 1 (mAbp1): a novel molecular player in leukocyte biology.
abstract: The transmittance of force from the actin cytoskeleton via integrins to extracellular ligands is essential for multiple aspects of leukocyte function. In addition, integrins must be efficiently linked to the cytoskeleton in order to resist external forces that act on the cell. Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as a novel adaptor involved in linking adhesion molecules of the β(2) integrin family to the actin cytoskeleton, indicating that this protein might have a fundamental impact on leukocyte functions that are associated explicitly with force transmittance; namely, intraluminal adhesion and phagocytosis. Here, we review the current understanding of the molecular and cellular functions of mAbp1 with a focus on its impact in leukocyte biology.
authors.affiliation: Walter Brendel Centre for Experimental Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schymeinsky
authors.forename: Markus
authors.initials: M
authors.lastname: Sperandio
authors.forename: Barbara
authors.initials: B
authors.lastname: Walzog
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D008840:Microfilament Proteins