title: [Expression and clinical relevance of uPA and ET-1 in non-small cell lung cancer].
abstract: OBJECTIVE
  uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Expressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed.
  
  
  RESULTS
  Negative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lymph node metastasis (P=0.017). Adenocarcinoma patients with high expression of uPA or with high expression of both ET-1 and uPA had the longer survival time (P=0.007 and 0.016).
  
  
  CONCLUSIONS
  Detection of uPA and ET-1 protein levels might contribute to the prognosis evaluation of NSCLC.
authors.affiliation: Key Laboratory of Biotic Environment and Ecological Safety in Anhui Province, College of Life Science, Anhui Normal University, Wuhu, China.
authors.forename: Yanyi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yizhen
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhizhou
authors.initials: Z
authors.lastname: Shi
authors.forename: Boshi
authors.initials: B
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Shang
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Shengzhou
authors.initials: S
authors.lastname: Zhang
authors.forename: Mingrong
authors.initials: M
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D019332:Endothelin-1 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015854:Up-Regulation; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics* / Q000378:metabolism
chemical_list: D019332:Endothelin-1; D014568:Urokinase-Type Plasminogen Activator