title: Discovery of a β-glucosidase inhibitor from a chemically engineered extract prepared through sulfonylation.
abstract: A semisynthetic β-glucosidase inhibitor was identified from a chemically engineered extract prepared by reaction with benzenesulfonyl chloride. The structure includes a natural histamine portion and a benzenesulfonyl portion introduced during the diversification step.
authors.affiliation: Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina.
authors.forename: Mario O
authors.initials: MO
authors.lastname: Salazar
authors.forename: Oscar
authors.initials: O
authors.lastname: Micheloni
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Escalante
authors.forename: Ricardo L E
authors.initials: RL
authors.lastname: Furlan
mesh_terms: D002616:Chemical Engineering; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D027003:Urticaceae / Q000737:chemistry; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D013450:Sulfones; D001617:beta-Glucosidase; C010544:benzenesulfonyl chloride