title: Restoration of chloride efflux by azithromycin in airway epithelial cells of cystic fibrosis patients.
abstract: Azithromycin (AZM) has shown promising anti-inflammatory properties in chronic obstructive pulmonary diseases, and clinical studies have presented an improvement in the respiratory condition of cystic fibrosis (CF) patients. The aim of this study was to investigate, in human airway cells, the mechanism by which AZM has beneficial effects in CF. We demonstrated that AZM did not have any anti-inflammatory effect on CF airway cells but restored Cl(-) efflux.
authors.affiliation: CDR St. Antoine, Inserm UMR-S 938, Paris F-75012, France.
authors.forename: Vinciane
authors.initials: V
authors.lastname: Saint-Criq
authors.forename: Carine
authors.initials: C
authors.lastname: Rebeyrol
authors.forename: Manon
authors.initials: M
authors.lastname: Ruffin
authors.forename: Telma
authors.initials: T
authors.lastname: Roque
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillot
authors.forename: Jacky
authors.initials: J
authors.lastname: Jacquot
authors.forename: Annick
authors.initials: A
authors.lastname: Clement
authors.forename: Olivier
authors.initials: O
authors.lastname: Tabary
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D002712:Chlorides / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000378:metabolism*; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D012137:Respiratory System / Q000166:cytology*
chemical_list: D000900:Anti-Bacterial Agents; D002712:Chlorides; D017963:Azithromycin