title: Percutaneous catheter-based intracoronary infusion of insulin--a dose finding study in the porcine model.
abstract: Insulin given at immediate reperfusion reduces myocardial infarct size in the in vitro and the ex vivo rat heart. In vivo, insulin may cause hypoglycaemia, hypokalaemia and elevation of catecholamines, potentially harmful during an acute myocardial infarction. The purpose of this study was to evaluate tolerance and safety of intracoronary insulin infusions in a porcine model applying percutaneous intervention techniques.
authors.affiliation: Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. grete.slettom@helse-bergen.no
authors.forename: Grete
authors.initials: G
authors.lastname: Slettom
authors.forename: Anne K
authors.initials: AK
authors.lastname: Jonassen
authors.forename: Vegard
authors.initials: V
authors.lastname: Tuseth
authors.forename: Reidar J
authors.initials: RJ
authors.lastname: Pettersen
authors.forename: Terje H
authors.initials: TH
authors.lastname: Larsen
authors.forename: Reinhard
authors.initials: R
authors.lastname: Seifert
authors.forename: Jan E
authors.initials: JE
authors.lastname: Nordrehaug
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D006328:Cardiac Catheterization; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects; D005215:Fasting; D005260:Female; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D007269:Injections, Intra-Arterial; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D020714:Maximum Tolerated Dose; D009203:Myocardial Infarction / Q000188:drug therapy*; D015425:Myocardial Reperfusion; D051381:Rats; D013552:Swine; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin