title: Mouse systems for studying the genetics of hypertension and related disorders.
abstract: The determination of cardiovascular diseases by multiple genetic and environmental factors makes it challenging to study the impact of any one genetic factor as a single variable. This review describes how to combine gene targeting in mice with carefully designed breeding strategies to determine the effect of precisely defined mutations as single variables. Studies of mice having mutations in cardiovascular genes should help to clarify the complex genetic determination of hypertension and related diseases. © 1996, Elsevier Science Inc. (Trends Cardiovasc Med 1996;6:232-238).
authors.forename: J H
authors.initials: JH
authors.lastname: Krege