title: Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.
abstract: The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.
authors.affiliation: Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pinto
authors.forename: Paola
authors.initials: P
authors.lastname: Conti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Grazioso
authors.forename: Lucia
authors.initials: L
authors.lastname: Tamborini
authors.forename: Ulf
authors.initials: U
authors.lastname: Madsen
authors.forename: Birgitte
authors.initials: B
authors.lastname: Nielsen
authors.forename: Carlo
authors.initials: C
authors.lastname: De Micheli
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D007555:Isoxazoles / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D058468:Receptors, Ionotropic Glutamate / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D007555:Isoxazoles; D008024:Ligands; D058468:Receptors, Ionotropic Glutamate