title: Radiosynthesis of [(18)F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins.
abstract: To probe the in vivo role of stress response factors in normal physiology and in solid tumors we have designed a stable (18)F-labeled molecular imaging agent based on a ligand for heat shock protein 70 (HSP70). We describe the synthesis of [(18)F] fluorodeoxymethylspergualin ([(18)F]MeDSG) as a new radiopharmaceutical probe using a prosthetic group, [(18)F]SFB, for efficient and rapid radiolabeling. Ongoing molecular imaging studies are under way to detect HSP70 expression in tumors by positron emission tomography.
authors.affiliation: Department of Radiology, Nuclear Medicine Division, The Methodist Hospital Research Institute, Weill Cornell Medical College, 6565 Fannin Street, Houston, TX 77030, USA.
authors.forename: Pradip
authors.initials: P
authors.lastname: Ghosh
authors.forename: King C
authors.initials: KC
authors.lastname: Li
authors.forename: Daniel Y
authors.initials: DY
authors.lastname: Lee
mesh_terms: D005462:Fluorine Radioisotopes; D006146:Guanidines / Q000138:chemical synthesis*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D007553:Isotope Labeling / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D005462:Fluorine Radioisotopes; D006146:Guanidines; D018840:HSP70 Heat-Shock Proteins; D019275:Radiopharmaceuticals; C557678:fluoromethyldeoxyspergualin; C076911:methyldeoxyspergualin