title: [Indoleamine 2,3-dioxygenase activity during chemotherapy or hormone therapy in patients with breast cancer].
abstract: We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) in breast cancer patients during chemotherapy or hormone therapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations about Trp/Kyn ratio between chemotherapy group and hormone therapy group in pre-chemotherapies or post-chemotherapies were studied. The Trp/Kyn ratio of chemotherapy group in post-FEC chemotherapy phase and in post-wPTX chemotherapy phase was higher than in pre-chemotherapy phase. And the Trp/Kyn ratio of chemotherapy group is significantly higher than hormone therapy in post-FEC chemotherapy phase and in post-wPTX chemotherapy phase. There were no significant changes for the Trp/Kyn ratio of hormone therapy group in each phase. These results suggest that the hormone therapy may be less invasive for breast cancer patients than the chemotherapy.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000201:enzymology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002851:Chromatography, High Pressure Liquid; D003520:Cyclophosphamide / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000032:analysis*; D007737:Kynurenine / Q000097:blood; D000077289:Letrozole; D008875:Middle Aged; D009570:Nitriles / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D014230:Triazoles / Q000008:administration & dosage; D014364:Tryptophan / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D009570:Nitriles; D014230:Triazoles; D007737:Kynurenine; D015251:Epirubicin; D000077289:Letrozole; D014364:Tryptophan; D003520:Cyclophosphamide; D017239:Paclitaxel; D005472:Fluorouracil