title: [Sonic Hedgehog signaling pathway: from embryology to molecular targeted therapies].
abstract: It has long been known that the hedgehog signaling pathway is crucial for embryonic development, in both Drosophila and vertebrate systems. During the past few years its implication in carcinogenesis has become clear and today it is acknowledged that this pathway plays a role in the malignant transformation of multiple cell types, either owing to the mutation of some of its components or to its erratic activation. New molecular targeted therapies that inhibit the pathway have shown their unquestionable efficiency in several tumours -among which basal cell carcinoma, medulloblastoma, or pancreatic adenocarcinoma. The assessment of these inhibitors in other types of tumours is currently underway with promising results, suggesting that the Sonic hedgehog signalling pathway may become one of the therapeutic targets of the future.
authors.affiliation: Service d'oncologie médicale, Groupe hospitalier Pitié-Salpêtrière, 75013 Paris, France, Laboratoire de pharmacobiologie des anticancéreux, Inserm U728, Hôpital Beaujon, 92113 Clichy, France.
authors.forename: S
authors.initials: S
authors.lastname: Watson
authors.forename: C
authors.initials: C
authors.lastname: Serrate
authors.forename: S
authors.initials: S
authors.lastname: Vignot
mesh_terms: D000813:Anilides / Q000627:therapeutic use; D000818:Animals; D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000235:genetics; D002528:Cerebellar Neoplasms / Q000235:genetics; D047108:Embryonic Development / Q000502:physiology*; D004627:Embryonic Induction / Q000502:physiology; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D008527:Medulloblastoma / Q000235:genetics; D058990:Molecular Targeted Therapy / Q000379:methods*; D009154:Mutation / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000235:genetics; D000072079:Patched Receptors; D018579:Patient Selection; D011725:Pyridines / Q000627:therapeutic use; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics; D055752:Small Cell Lung Carcinoma / Q000235:genetics
chemical_list: D000813:Anilides; D053823:Hedgehog Proteins; C538724:HhAntag691; D000072079:Patched Receptors; D011725:Pyridines; D011956:Receptors, Cell Surface