title: Parental consanguineous marriages and clinical response to chemotherapy in locally advanced breast cancer patients.
abstract: The main aim of the present study was investigating the association between parental consanguinity and clinical response to chemotherapy in females affected with locally advanced breast cancer. A consecutive series of 92 patients were prospectively included in this study. Clinical assessment of treatment was accomplished by comparing initial tumor size with preoperative tumor size using revised RECIST guideline (version 1.1). Clinical response defined as complete response, partial response and no response. The Kaplan-Meier survival analysis were used to evaluate the association of parental marriages (first cousin vs unrelated marriages) and clinical response to chemotherapy (complete and partial response vs no response). Number of courses of chemotherapy was considered as time, in the analysis. Kaplan-Meier analysis revealed that offspring of unrelated marriages had poorer response to chemotherapy (log rank statistic=5.10, df=1, P=0.023).
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran. saadat@susc.ac.ir
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
authors.forename: Maryam
authors.initials: M
authors.lastname: Khalili
authors.forename: Shahpour
authors.initials: S
authors.lastname: Omidvari
authors.forename: Maryam
authors.initials: M
authors.lastname: Ansari-Lari
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D003241:Consanguinity; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D011795:Surveys and Questionnaires; D047368:Tumor Burden