title: Histopathological study of spinal meningioma originating from the arachnoid villi.
abstract: Although the histogenesis of meningiomas remains unclear, it is believed that arachnoid cells are the most likely origin of this type of neoplasm. Further, little attention has been paid to the histopathology of spinal meningiomas arising from the arachnoid villi. We came across a case of spinal meningioma that was locally attached to the arachnoid membrane. The associated arachnoid villi were investigated by light microscopy and immunohistochemical analysis. We confirmed the presence of tumor cells under the fibrous capsule that forms the outer component of the arachnoid villi. Tumor cells grew out from the apical portion of the arachnoid villi. Furthermore, immunohistochemical study suggested that arachnoid cells made the transition to tumor cells on the arachnoid cell layer.
authors.affiliation: Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. yuchan245@aol.com
authors.forename: Yu-ichiro
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Koichi
authors.initials: K
authors.lastname: Iwatsuki
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.forename: Maki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Hori
authors.forename: Takashi
authors.initials: T
authors.lastname: Moriwaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishihara
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Masao
authors.initials: M
authors.lastname: Umegaki
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yoshimine
mesh_terms: D000368:Aged; D001099:Arachnoid / Q000166:cytology / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D019635:Neurosurgical Procedures