title: Pseudosarcomatous proliferation of cx43- and kit-expressing interstitial cell in the urinary bladder.
abstract: The authors report a case showing proliferation of KIT- and connexin 43-expressing mesenchymal cells of the urinary bladder. A 75-year-old woman had an ulcerated endophytic mass (size, approximately 2 × 2 cm) in the left posterolateral wall. She underwent transurethral resection and subsequent partial cystectomy. The suburothelial mass extended to the muscularis propria. The histopathological analysis revealed spindle-shaped mesenchymal cells that were loosely arranged with myxoid stroma and showed a focal compact fascicular arrangement. In the immunohistochemical analysis, these spindle cells were stained with specific antibodies to KIT and connexin 43. The patient is currently free of disease at 5 years after operation. The proliferating spindle cells in the present case might represent a phenotype of interstitial cells of the lamina propria.
authors.affiliation: Department of Pathology, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Masanobu
authors.initials: M
authors.lastname: Tanimura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Shimamoto
authors.forename: Masaharu
authors.initials: M
authors.lastname: Yasuda
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Furihata