title: Virilization with adrenal myelolipoma, adrenal hyperplasia, and fibroadenoma of breast.
abstract: Adrenal myelolipoma is a rare, benign and usually hormonally inactive tumour. We report a case of a young female who presented with hormonally active tumour causing virilization and associated type-2 Diabetes mellitus. Laparoscopic adrenalectomy was done after CT finding of a large left adrenal mass that was producing large amounts of androgens. Adrenal myelolipoma with cortical hyperplasia was diagnosed on histopathological examination. Her diabetes progressively regressed after the removal of tumour and glucose tolerance remained normal up to 1 year of follow-up after surgery and there was no recurrence of tumour. She also had a lump in her breast which proved to be a fibroadenoma. We report this case due to its rarity, multiplicity of tumours and adrenal cortical hyperplasia-presenting as an unusual cause of severe virilization.
authors.affiliation: Medical Unit-II, Jinnah Postgraduate Medical Centre, Karachi. mef.foundation@gmail.com
authors.forename: Tasnim
authors.initials: T
authors.lastname: Ahsan
authors.forename: Subheen
authors.initials: S
authors.lastname: Kanwal
authors.forename: Zeenat
authors.initials: Z
authors.lastname: Banu
authors.forename: Rukhshanda
authors.initials: R
authors.lastname: Jabeen
mesh_terms: D000302:Adrenal Cortex / Q000473:pathology*; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D001943:Breast Neoplasms / Q000150:complications* / Q000601:surgery; D048909:Diabetes Complications; D005260:Female; D018226:Fibroadenoma / Q000150:complications* / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D015412:Mastectomy, Segmental; D018209:Myelolipoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis; D014770:Virilism / Q000209:etiology*