title: Tandem reactions leading to bicyclic pyrimidine nucleosides and benzopyran-4-ones.
abstract: A novel, rapid, and efficient synthesis of bicyclic pyrimidine nucleosides and benzopyran-4-ones through oxidation of homopropargyl alcohols and subsequent isomerization, intramolecular addition of enol to allenic ketone has been developed. This methodology provides an efficient and promising approach to the structurally and pharmaceutically interesting pyrano[2,3-d]pyrimidine-2,5-dione nucleoside and benzopyran-4-one derivatives.
authors.affiliation: Henan Normal University, Xinxiang, People's Republic of China. xuesen.fan@henannu.edu.cn
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Wang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qu
authors.forename: Haiyun
authors.initials: H
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Jianji
authors.initials: J
authors.lastname: Wang
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001578:Benzopyrans; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007659:Ketones; D011741:Pyrimidine Nucleosides