title: Change in predicted 10-year cardiovascular risk following Roux-en-Y gastric bypass surgery: who benefits?
abstract: BACKGROUND
  The risk of developing cardiovascular disease is higher in obese than in non-obese individuals. Surgery for obesity is effective in reducing weight and resolution of diabetes, hypertension, and dyslipidemia. Our aim was to assess the estimated 10-year cardiovascular risk of obese patients before and after treatment of obesity with a gastric bypass.
  
  
  METHODS
  Weight, body mass index systolic and diastolic blood pressure, lipid profile, glycemia, and history of cardiovascular disease were obtained for obese patients before and 2 years after Roux-en-Y gastric bypass surgery. Ten-year cardiovascular risk was calculated using the Framingham score.
  
  
  RESULTS
  Forty-two patients were included in the study. We observed a significant reduction (p < 0.05) of 10-year cardiovascular risk mainly associated with weight reduction and improvement of comorbidities associated with obesity. The benefits were greater among patients who already presented known risk factors such as diabetes and hypertension. Superobese patients benefited as early as 2 years after surgery, when weight loss was greater.
  
  
  CONCLUSIONS
  Weight loss secondary to surgery was sustained after 2 years and promoted improvement of comorbidities, with an important reduction of 10-year cardiovascular risk especially among patients with previous risk factors.
authors.affiliation: Division of Nutrology, Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Simara P
authors.initials: SP
authors.lastname: Donadelli
authors.forename: Wilson
authors.initials: W
authors.lastname: Salgado
authors.forename: Julio S
authors.initials: JS
authors.lastname: Marchini
authors.forename: Andre
authors.initials: A
authors.lastname: Schmidt
authors.forename: Cristiana A F
authors.initials: CA
authors.lastname: Amato
authors.forename: Reginaldo
authors.initials: R
authors.lastname: Ceneviva
authors.forename: Jose Ernesto
authors.initials: JE
authors.lastname: Dos Santos
authors.forename: Carla Barbosa
authors.initials: CB
authors.lastname: Nonino
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D015390:Gastric Bypass; D006801:Humans; D009752:Nutritional Status; D009767:Obesity, Morbid / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies; D018570:Risk Assessment; D015431:Weight Loss / Q000502:physiology