title: LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM.
abstract: Obesity-induced adipose tissue inflammation is characterized by increased macrophage infiltration and cytokine production, and is associated with metabolic disorders. LIGHT/TNFSF14, a member of the TNF superfamily, plays a role in the development of various inflammatory diseases. The purpose of this study was to examine the involvement of soluble LIGHT (sLIGHT) in obesity-induced adipose tissue inflammatory responses. LIGHT gene expression on macrophages/adipocytes was upregulated by treatment with obesity-related factors. sLIGHT displayed chemotactic activity for macrophages and T cells, and enhanced inflammatory cytokine release from macrophages, adipocytes, and adipose tissue-derived SVF cells. The sLIGHT-induced inflammatory responses were blunted by neutralizing anti-HVEM antibody or knockout of HVEM, a receptor for sLIGHT. These findings indicate that sLIGHT enhances adipose tissue inflammatory responses through its interaction with HVEM.
authors.affiliation: Department of Biological Science, University of Ulsan, Nam-ku, Ulsan, South Korea.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Choon-Soo
authors.initials: CS
authors.lastname: Jeong
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Choi
authors.forename: Teruo
authors.initials: T
authors.lastname: Kawada
authors.forename: Rina
authors.initials: R
authors.lastname: Yu
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D052436:Adipose Tissue, White / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002633:Chemotaxis; D017077:Culture Media, Conditioned; D016207:Cytokines / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage; D005786:Gene Expression Regulation; D018836:Inflammation Mediators / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009765:Obesity / Q000378:metabolism*; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000378:metabolism; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14 / Q000235:genetics / Q000378:metabolism*
chemical_list: D017077:Culture Media, Conditioned; D016207:Cytokines; D004041:Dietary Fats; D018836:Inflammation Mediators; D012333:RNA, Messenger; D053240:Receptors, Tumor Necrosis Factor, Member 14; C506029:Tnfrsf14 protein, mouse; C505915:Tnfsf14 protein, mouse; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14