title: Sleep-disordered breathing and arterial blood flow steal represent linked therapeutic targets in cerebral ischaemia.
abstract: The pathogenic link between sleep-disordered breathing and early neurological deterioration in acute ischaemic stroke patients is now a subject of clinical investigations. Vasomotor reactivity and intracranial blood flow steal in response to changing vasodilatory stimuli like carbon dioxide play a pivotal role in clinical deterioration with reversed Robin Hood syndrome. A mechanical ventilatory correction in selected acute stroke patients might have a beneficial effect on sleep-disordered breathing and brain perfusion. This is a novel therapeutic target and the missing link in the pathogenesis of early neurological deterioration and stroke recurrence.
authors.affiliation: Department of Neurology, Dresden University Stroke Center, University of Technology Dresden, Dresden, Germany. Kristian.Barlinn@uniklinikum-dresden.de
authors.forename: Kristian
authors.initials: K
authors.lastname: Barlinn
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Alexandrov
mesh_terms: D002545:Brain Ischemia / Q000628:therapy*; D002245:Carbon Dioxide / Q000378:metabolism; D002539:Cerebral Arterial Diseases / Q000628:therapy*; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology / Q000628:therapy; D012121:Respiration, Artificial; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000628:therapy*; D020521:Stroke / Q000209:etiology / Q000628:therapy
chemical_list: D002245:Carbon Dioxide