title: Substituted imidazole derivatives as novel cardiovascular agents.
abstract: A series of novel substituted imidazole derivatives were synthesized and have been screened in vivo for their hypotensive and acute toxicity activities. Out of seventeen compounds eight compounds (2b, 2c, 3b, 3c, 3f, 4a, 4b and 4c) have shown good hypotensive and bradycardiac responses. Compounds 3b, 3c, 3f and 4c have shown better activity than reference drug clonidine. All the compounds have shown ALD50>1000 mg/kg with maximum in 2e and 4c (>1200 mg/kg).
authors.affiliation: Department of Pharmacology & Therapeutics, CSJMMU, Lucknows, India.
authors.forename: Vineet
authors.initials: V
authors.lastname: Malhotra
authors.forename: Seema R
authors.initials: SR
authors.lastname: Pathak
authors.forename: Rajendra
authors.initials: R
authors.lastname: Nath
authors.forename: Devashish
authors.initials: D
authors.lastname: Mukherjee
authors.forename: K
authors.initials: K
authors.lastname: Shanker
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002415:Cats; D006339:Heart Rate / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D002317:Cardiovascular Agents; D007093:Imidazoles; C029899:imidazole