title: Lessons from an anti-DNA autoantibody.
abstract: R4A is an anti-DNA antibody derived by hybridoma technology from a BALB/c mouse. The study of its properties has helped to elucidate aspects of the physiopathology of Systemic Lupus Erythematosus (SLE). It has been useful to decipher the mechanisms implicated in breaks in B cell self tolerance by B cell extrinsic or B cell intrinsic factors. Furthermore, it illustrates the importance of molecular mimicry in understanding the cellular and molecular effects relevant to some manifestations of neuropsychiatric lupus, as it cross-reacts with the D/E W D/E YS/G peptide sequence present in subunits of the N-methyl d-aspartate receptor (NMDAR).
authors.affiliation: The Feinstein Institute for Medical Research, Center for Autoimmune and Musculoskeletal Diseases, Manhasset, NY 11030, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Cohen-Solal
authors.forename: Betty
authors.initials: B
authors.lastname: Diamond
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D001812:Blood-Brain Barrier / Q000276:immunology; D001921:Brain / Q000196:embryology / Q000276:immunology; D005260:Female; D047109:Fetal Development / Q000276:immunology; D006801:Humans; D007437:Intrinsic Factor / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D018716:Molecular Mimicry / Q000276:immunology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology; D017634:Self Tolerance / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D016194:Receptors, N-Methyl-D-Aspartate; D007437:Intrinsic Factor