title: Developmental biology: extending the limb and body with vectors and scalars.
abstract: Outgrowth of the embryonic limb in vertebrates is driven by a proximodistal gradient of cell movement, with WNT and FGF activities controlling direction and velocity, respectively. A similar gradient, though without a directional bias, drives caudal body axis extension.
authors.affiliation: Cancer and Developmental Biology Laboratory, National Cancer Institute, NCI-Frederick, Frederick, MD 21702, USA. lewandom@mail.nih.gov
authors.forename: Mark
authors.initials: M
authors.lastname: Lewandoski
authors.forename: Susan
authors.initials: S
authors.lastname: Mackem
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002465:Cell Movement; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D015398:Signal Transduction; D014714:Vertebrates / Q000196:embryology*