title: [Effects of electroacupuncture of "source-" plus "collateral-" acupoints on the cardiac function and myocardial enzymes in acute myocardial ischemia rabbits].
abstract: OBJECTIVE
  To observe the effects of electroacupuncture (EA) of "Source-" + "Collateral-" acupoints ["Shenmen" (HT 7) + "Zhizheng"(SI 7)] and single acupoints "Neiguan"(PC 6) and HT 7 on cardiac function and myocardial enzymes in acute myocardial ischemia (AMI) rabbits.
  
  
  METHODS
  Sixty Chinchilla rabbits were randomized into normal control, model, Shenmen (HT 7), Neiguan (PC 6), HT 7 + SI 7 groups, with 8 rabbits in each. AMI model was duplicated by occlusion of the anterior descending branch of left coronary artery under anesthesia. EA (2 Hz,1 mA) was applied to acupoints HT 7, PC 6,and HT 7 + SI 7 for 10 min. The maximum ascending rate (+ dp/dt max) and maximum descending rate (-dp/dt max) of the left ventricular pressure (LVP) were recorded by using PowerLab System. Serum lactate dehydrogenase (LDH) and creatine kinase MB (CK-MB) contents were detected with chromatometry.
  
  
  RESULTS
  Serum LDH and OK-MB contents increased significantly in model group than in normal control group (P < 0.01). Compared with model group, serum LDH and CK-MB contents decreased remarkably in PC 6, HT 7 and HT 7 + SI 7 groups (P < 0.01, P < 0.05), and the effects of HT 7 + SI 7 group were significantly superior to those of PC 6 and HT 7 groups in lowering serum LDH and CK-MB levels (P < 0.01, P < 0.05). Compared with the normal control group, + dp/dt max lowered significantly and -dp/dt max increased markedly in the model group (P < 0.01), while compared with the model group, + dp/dt max increased obviously and -dp/dt max decreased significantly in the three EA groups (P < 0.01, P < 0.05). The effects of HT 7 + SI 7 group were markedly superior to those of HT 7 and PC 6 in raising + dp/dt max and lowering -dp/dt max (P < 0.05, P < 0.01), and those effects of PC 6 group were evidently better than those of HT 7 group (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  EA of "Source-" + "Collateral-" aoupoints (HT 7 + SI 7), HT 7 and PC 6 has a positive effect in improving changes of cardiac function and in lowering serum LDH and CK-MB contents in AMI rabbits, and the effect of EA of HT 7 + SI 7 is superior to that of EA of single acupoint.
authors.affiliation: Research Institute of Acu-Moxibustion and Meridians, Anhui College of Chinese Medicine, Anhui Key Laboratory of Foundation and Technology of Acu-Moxibustion Cultivating Base, Hefei 230038, China. hulingtcm@126.com
authors.forename: Ling
authors.initials: L
authors.lastname: Hu
authors.forename: Lu
authors.initials: L
authors.lastname: He
authors.forename: Rong-Lin
authors.initials: RL
authors.lastname: Cai
authors.forename: Di-He
authors.initials: DH
authors.lastname: Long
authors.forename: Zi-Jian
authors.initials: ZJ
authors.lastname: Wu
mesh_terms: D015669:Acupuncture Points; D000818:Animals; D001794:Blood Pressure; D052279:Creatine Kinase, MB Form / Q000097:blood / Q000378:metabolism; D004195:Disease Models, Animal; D015671:Electroacupuncture; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000201:enzymology / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000201:enzymology*; D011817:Rabbits; D011897:Random Allocation
chemical_list: D007770:L-Lactate Dehydrogenase; D052279:Creatine Kinase, MB Form