title: [Preventive effects of cerebro cellular growth peptide on gentamycin-induced inner ear damage in guinea pigs].
abstract: OBJECTIVE
  To investigate the preventive effects of the cerebro cellular growth peptide (CCGP) on gentamycin-induced inner ear damage in guinea pigs, and to clarify its mechanism.
  
  
  METHODS
  The hypoacusis severity and enzymatic activity in the cochlear hair cells were examined by brainstem auditory evoked potential (BAEP) and histochemistry, respectively. The damaged hair cells was counted in three groups.
  
  
  RESULTS
  CCGP reduced the elevated BAEP reaction thresholds. It protected activities of mitochondrial succinate dehydrogenase and lysosome acid phosphatase in the cochlear hair cells. The number of damaged hair cells in the CCGP group was less than that in the gentamycin (GM) group.
  
  
  CONCLUSIONS
  CCGP can reduce GM ototoxicity. The mechanism may be associated with the protective activity of mitochondrial enzyme, the maintenance of lysosome intactness, energy metabolism of the cochlear hair cells, and reduction of autolysis of hair cells induced by hydrolase over flowing from lysosome.
authors.affiliation: Department of Physiology, Taishan Medical College, Shangdong 271000, China.
authors.forename: Song-Jian
authors.initials: SJ
authors.lastname: Kang
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Shi
authors.forename: You-Zhen
authors.initials: YZ
authors.lastname: Wei
authors.forename: An
authors.initials: A
authors.lastname: Hong
authors.forename: Xin-Quan
authors.initials: XQ
authors.lastname: Jiang
mesh_terms: D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000502:physiology; D008297:Male; D020932:Nerve Growth Factor / Q000494:pharmacology*
chemical_list: D005839:Gentamicins; D020932:Nerve Growth Factor