title: Interictal epileptiform discharges and asystole.
abstract: We describe a case of a patient with Lennox-Gastaut syndrome who had asystole and sinus bradycardia during interictal epileptiform abnormalities on EEG. Video-EEG/EKG monitoring prior to corpus callosotomy recorded consistent prolongation of the R-R interval on the EKG during bursts of epileptiform abnormalities (generalized paroxysmal fast activity), which became transiently more pronounced after surgery. These findings reveal that interictal epileptiform abnormalities may cause significant cardiac arrhythmias in some individuals.
authors.affiliation: Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, United States. Maromi.Nei@jefferson.edu
authors.forename: Maromi
authors.initials: M
authors.lastname: Nei
authors.forename: Andro T
authors.initials: AT
authors.lastname: Zangaladze
authors.forename: Ashwini
authors.initials: A
authors.lastname: Sharan
authors.forename: Reginald T
authors.initials: RT
authors.lastname: Ho
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001919:Bradycardia / Q000209:etiology / Q000503:physiopathology; D003337:Corpus Callosum / Q000601:surgery; D004562:Electrocardiography; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology; D006323:Heart Arrest / Q000503:physiopathology*; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology; D065768:Lennox Gastaut Syndrome; D008297:Male; D019635:Neurosurgical Procedures; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology*; D013036:Spasms, Infantile / Q000503:physiopathology; D055815:Young Adult
chemical_list: D000927:Anticonvulsants