title: Longitudinal association of preference-weighted health-related quality of life measures and substance use disorder outcomes.
abstract: OBJECTIVE
  To examine the construct validity of generic preference-weighted health-related quality of life measures in a sample of patients with a substance use disorder (SUD).
  
  
  METHODS
  Longitudinal (baseline and 6-month follow-up) data from a research study that evaluated interventions to improve linkage and engagement with SUD treatment.
  
  
  METHODS
  A central intake unit that referred patients to seven SUD treatment centers in a Midwestern US metropolitan area.
  
  
  METHODS
  A total of 495 individuals with a SUD.
  
  
  METHODS
  Participants completed two preference-weighted measures: the self-administered Quality of Well-Being scale (QWB-SA) and the standard gamble weighted Medical Outcomes Study SF-12 (SF-6D). They were also administered two clinical assessments: all seven domains of the Addiction Severity Index (ASI) and a symptom checklist based on the DSM-IV. Construct validity was determined via the relationships between disease-specific SUD and generic measures.
  
  
  RESULTS
  In unadjusted analyses, the QWB-SA and SF-6D change scores were correlated significantly with six ASI subscale change scores, but not with employment status. In adjusted repeated-measures analyses, three of seven ASI subscale scores were significant predictors of QWB-SA and 5/7 ASI subscale scores were significant predictors of SF-6D. Abstinence and problematic use at follow-up were significant predictors of QWB-SA and SF-6D. Effect sizes ranged from 0.352 to 0.400 for abstinence and -0.484 to -0.585 for problematic use.
  
  
  CONCLUSIONS
  Generic preference-weighted health-related quality of life measures show moderate to good associations with substance-use specific measures and in certain circumstances can be used in their stead. This study provides further support for the use of the Quality of Well-Being scale and Medical Outcomes Study SF-12 in clinical and economic evaluations of substance use disorder interventions.
authors.affiliation: Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, Little Rock, USA. jmpyne@uams.edu
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Pyne
authors.forename: Shanti
authors.initials: S
authors.lastname: Tripathi
authors.forename: Michael
authors.initials: M
authors.lastname: French
authors.forename: Kathryn
authors.initials: K
authors.lastname: McCollister
authors.forename: Richard C
authors.initials: RC
authors.lastname: Rapp
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Booth
mesh_terms: D000293:Adolescent; D000328:Adult; D003362:Cost-Benefit Analysis; D003627:Data Interpretation, Statistical; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010342:Patient Acceptance of Health Care; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012720:Severity of Illness Index; D016320:Substance Abuse Treatment Centers / Q000191:economics; D019966:Substance-Related Disorders / Q000191:economics / Q000523:psychology* / Q000628:therapy; D011795:Surveys and Questionnaires / Q000592:standards*; D014481:United States