title: In vitro effect of Knotolan, a new lignan from Abies sibirica, on the growth of hormone-dependent breast cancer cells.
abstract: Here we present antiestrogenic effects of Knotolan, a new dietary lignan from Abies sibirica raw material. Knotolan abolished growth-stimulating effects of 17β-estradiol on hormone-dependent MCF-7 cells.
authors.affiliation: N N Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Zhukova
authors.forename: L V
authors.initials: LV
authors.lastname: Fetisova
authors.forename: A V
authors.initials: AV
authors.lastname: Trishin
authors.forename: N Yu
authors.initials: NY
authors.lastname: Anisimova
authors.forename: A M
authors.initials: AM
authors.lastname: Scherbakov
authors.forename: A E
authors.initials: AE
authors.lastname: Shcherbakov
authors.forename: D V
authors.initials: DV
authors.lastname: Yashunskii
authors.forename: D E
authors.initials: DE
authors.lastname: Tsvetkov
authors.forename: V M
authors.initials: VM
authors.lastname: Men'shov
authors.forename: M V
authors.initials: MV
authors.lastname: Kiselevskii
authors.forename: N E
authors.initials: NE
authors.lastname: Nifant'ev
mesh_terms: D028202:Abies / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy*; D002072:Butylene Glycols / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D017705:Lignans / Q000627:therapeutic use*; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*
chemical_list: D002072:Butylene Glycols; D017705:Lignans; D004958:Estradiol; C060283:secoisolariciresinol