title: Nuclear architecture in stem cells.
abstract: Fundamental features of genome regulation depend on the linear DNA sequence, cell type specific modification of DNA and chromatin-associated proteins, which locally control the expression of single genes. Architectural features of genome organization within the three-dimensional (3D) nuclear space establish preferential positioning of genes relative to nuclear subcompartments associated with specific biochemical activities, thereby influencing states of expression. The structural and temporal organization of the genome within the nucleus of stem cells, together with specific features of epigenetic and transcriptional regulation are emerging as key players that influence pluripotency and differentiation.1,2.
authors.affiliation: Genome Function Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Morris
authors.forename: Mita
authors.initials: M
authors.lastname: Chotalia
authors.forename: Ana
authors.initials: A
authors.lastname: Pombo
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D005786:Gene Expression Regulation; D016678:Genome; D013234:Stem Cells
chemical_list: D002843:Chromatin