title: A case of Budd-Chiari syndrome: Gd-EOB-DTPA-enhanced MR findings.
abstract: Budd-Chiari syndrome (BCS) is a rare disorder caused by the obstruction of hepatic venous outflow, leading to sinusoidal congestion, ischemic injury to liver cells and portal hypertension. Long-term survival largely depends on whether hepatocellular carcinoma occurs. A recently available liver-specific contrast medium, gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA), reportedly has high diagnostic capability for detection of malignant liver tumors. However, there has been no report of the sue of Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for BCS. We present a case of chronic BCS who underwent both gadopentetate dimeglumine (Gd-DTPA) and Gd-EOB-DTPA-enhanced MRI. Hepatic congestion and edema were seen as slightly hypointense areas on Gd-EOB-DTPA-enhanced hepatobiliary-phase images, although these areas were observed as slightly hyperintense on previously obtained Gd-DTPA-enhanced delayed-phase image. Reduced uptake of Gd-EOB-DTPA by hepatocytes in the region of congestion or edema may account for this difference, which should be recognized in image interpretations.
authors.affiliation: Clinical PET Center, Institute of Biomedical Research and Innovation, Kobe, Japan. yoshikaw@med.kobe-u.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kitajima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Seo
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ohno
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yano
authors.forename: Akira
authors.initials: A
authors.lastname: Miki
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kanda
authors.forename: Naoki
authors.initials: N
authors.lastname: Kanata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Azuma
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugimura
mesh_terms: D000328:Adult; D006502:Budd-Chiari Syndrome / Q000175:diagnosis*; D003287:Contrast Media / Q000494:pharmacology; D004487:Edema; D005260:Female; D019786:Gadolinium DTPA / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA