title: Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse.
abstract: Primitive neuroectodermal tumors (PNET) originating within the spinal cord are extraordinarily rare. We report a female who presented at age 21 with diffuse involvement of the lower spinal cord. After biopsy and successful treatment with radiation and chemotherapy, she recurred 10 years later with disease in her cerebellum. She was reinduced with chemotherapy and subsequently received high-dose chemotherapy with autologous stem cell support. She is alive and free of disease 11 years after her initial presentation. This represents the longest survival ever documented for a primary spinal PNET.
authors.affiliation: Cancer and Blood Specialists of Nevada, Henderson, NV 89074, USA. rgollard@hotmail.com
authors.forename: Russell P
authors.initials: RP
authors.lastname: Gollard
authors.forename: Larry
authors.initials: L
authors.lastname: Rosen
authors.forename: John
authors.initials: J
authors.lastname: Anson
authors.forename: James
authors.initials: J
authors.lastname: Mason
authors.forename: Joe
authors.initials: J
authors.lastname: Khoury
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002066:Busulfan / Q000008:administration & dosage; D002528:Cerebellar Neoplasms / Q000188:drug therapy / Q000556:secondary; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D018242:Neuroectodermal Tumors, Primitive / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011878:Radiotherapy; D013125:Spinal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D000077204:Temozolomide; D013852:Thiotepa / Q000008:administration & dosage; D013904:Thoracic Vertebrae; D014750:Vincristine / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D018696:Neuroprotective Agents; D008776:Methylprednisolone Hemisuccinate; D014750:Vincristine; D005047:Etoposide; D003606:Dacarbazine; D003520:Cyclophosphamide; D013852:Thiotepa; D002066:Busulfan; D002945:Cisplatin; D000077204:Temozolomide