title: On the involvement of H2S in nitroso signaling and other mechanisms of H2S action.
abstract: Both endogenously produced and exogenously administered H2S exert numerous biological effects. However, the molecular mechanisms underlying these effects are not fully understood. This review surveys the biological effects of H2S and summarizes the molecular mechanisms of H2S action. It focuses on the role of H2S/HS--induced NO release from nitroso compounds, modulation of ion channels and the antioxidant and radical properties of H2S in the molecular mechanism of its effects. The potential involvement of H2S in nitroso signaling underlying its diverse biological effects is also discussed.
authors.affiliation: Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava,Slovak Republic. zuzana.tomaskova@savba.sk
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Tomaskova
authors.forename: Anna
authors.initials: A
authors.lastname: Bertova
authors.forename: Karol
authors.initials: K
authors.lastname: Ondrias
mesh_terms: D000818:Animals; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009603:Nitroso Compounds / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism
chemical_list: D005609:Free Radicals; D009603:Nitroso Compounds; D011506:Proteins; D009569:Nitric Oxide; D006862:Hydrogen Sulfide