title: [Prediction of clinical course of glioblastomas by MRI during radiotherapy].
abstract: OBJECTIVE
  determine the value of MR studies in patients undergoing radiotherapy for glioblastomas pre and during radiotherapy to predict the clinical course.
  
  
  METHODS
  MR follow-up studies were performed in 33 patients with glioblastomas before radiotherapy, after 30 Gy, after 60 Gy, and in the treatment follow-up. Findings on MR were categorized into: definite progress, questionable progress, status idem. Patients were followed clinically (median for 11 months).
  
  
  RESULTS
  after 30 Gy 23/33 (70%) of the MR examination showed status idem. 10/33 (30%) demonstrated definite (n = 6) or questionable (n = 4) progress. Further tumor progress was faster in these patients and patients succumb to their disease earlier (9 vs. 22 months). The 60 Gy study showed definite (n = 8) and questionable (n = 6) progress in 14/33 (42%) cases. All these tumors were progressing faster and were associated with a comparatively reduced life expectancy.
  
  
  CONCLUSIONS
  MR follow-up studies after 30 Gy in patients undergoing radiotherapy for glioblastomas allow for prognostic appraisal, and potentially early modification of treatment.
authors.affiliation: Radiologische Klinik, FE Strahlentherapie, Universitätsklinik Bonn, Bonn, Deutschland. christina.leitzen@ukb.uni-bonn.de
authors.forename: Christina
authors.initials: C
authors.lastname: Leitzen
authors.forename: Hans H
authors.initials: HH
authors.lastname: Schild
authors.forename: Birgitta
authors.initials: B
authors.lastname: Bungart
authors.forename: Ulrich
authors.initials: U
authors.lastname: Herrlinger
authors.forename: Christiana
authors.initials: C
authors.lastname: Lütter
authors.forename: Thomas
authors.initials: T
authors.lastname: Müdder
authors.forename: Timo
authors.initials: T
authors.lastname: Wilhelm-Buchstab
authors.forename: Heinrich
authors.initials: H
authors.lastname: Schüller
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011379:Prognosis; D011879:Radiotherapy Dosage; D015996:Survival Rate