title: [Transrectal real-time tissue elastography combined with grey-scale ultrasound: valuable for the diagnosis of prostate peripheral zone lesions].
abstract: OBJECTIVE
  To investigate the value of strain patterns by transrectal real-time tissue elastography (TRTE) combined with transrectal ultrasonography (TRUS) in the differential diagnosis of the peripheral zone lesions of the prostate.
  
  
  METHODS
  A total of 145 patients suspected of prostate cancer (PCa) underwent TRUS and TRTE examinations. Based on the features of the strain patterns, the lesions were classified into 5 grades, and the strain patterns were compared with the results of pathological diagnosis.
  
  
  RESULTS
  High-quality images of TRTE were obtained in 124 (52 malignant and 72 benign) of the cases. According to the pathological results, malignancies accounted for 6.8% (3/44) in Grade I, 23.1% (3/13) in Grade II, 31.3% (5/16) in Grade III, 75.6% (31/41) in Grade IV and 100% (10/10) in Grade V, with statistically significant differences among the 5 grades (chi2 = 57.9, P < 0.01), and the diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were 88.5%, 70.8%, 78.2%, 68.7% and 89.5% for TRTE, in comparison with 78.8%, 86.1%, 83.1%, 80.4% and 84.9% for the combination of TRTE and TRUS.
  
  
  CONCLUSIONS
  The combined use of strain patterns and TRUS is helpful to the differential diagnosis of prostate peripheral zone lesions.
authors.affiliation: Department of Ultrasound, General Hospital of Chinese PLA, Beijing 100853, China. zhangyaner301@yahoo.com.cn
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.forename: Yan-Mi
authors.initials: YM
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Fei
authors.forename: Zhi-Yan
authors.initials: ZY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011467:Prostate / Q000000981:diagnostic imaging*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D012007:Rectum / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional / Q000379:methods*