title: SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma.
abstract: Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10⁻⁹) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.
authors.affiliation: Centre for Haemato-Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. d.j.wrench@qmul.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Wrench
authors.forename: Pamela
authors.initials: P
authors.lastname: Leighton
authors.forename: Christine F
authors.initials: CF
authors.lastname: Skibola
authors.forename: Lucia
authors.initials: L
authors.lastname: Conde
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Cazier
authors.forename: Janet
authors.initials: J
authors.lastname: Matthews
authors.forename: Sameena
authors.initials: S
authors.lastname: Iqbal
authors.forename: Emanuela
authors.initials: E
authors.lastname: Carlotti
authors.forename: Csaba
authors.initials: C
authors.lastname: Bödör
authors.forename: Silvia
authors.initials: S
authors.lastname: Montoto
authors.forename: Maria
authors.initials: M
authors.lastname: Calaminici
authors.forename: John G
authors.initials: JG
authors.lastname: Gribben
authors.forename: T Andrew
authors.initials: TA
authors.lastname: Lister
authors.forename: Jude
authors.initials: J
authors.lastname: Fitzgibbon
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013997:Time Factors; D006113:United Kingdom
chemical_list: D006680:HLA Antigens