title: Breastfeeding and risk of epilepsy in childhood: a birth cohort study.
abstract: OBJECTIVE
  We asked whether breastfeeding reduces the risk of epilepsy in childhood.
  
  
  METHODS
  We included 69 750 singletons born between September 1997 and June 2003 in the Danish National Birth Cohort and observed them to August 2008. Information on breastfeeding was reported by mothers in two computer-assisted telephone interviews at 6 and 18 months after birth. Information on epilepsy (inpatients and outpatients) was retrieved from the Danish National Hospital Register. Cox proportional hazards regression models were used to estimate incidence rate ratios and 95% CIs.
  
  
  RESULTS
  Breastfeeding was associated with a decreased risk of epilepsy, with a dose-response like pattern. For example, children breastfed for 3 to 5, 6 to 8, 9 to 12, and ≥ 13 months had a 26%, 39%, 50%, and 59% lower risk of epilepsy after the first year of life, respectively, compared with children who were breastfed for <1 month. The association remained when we excluded children who had adverse neonatal conditions or children who were exposed to adverse maternal conditions during pregnancy.
  
  
  CONCLUSIONS
  The observed protective effect of breastfeeding may be causal. Breastfeeding may decrease epilepsy in childhood, thereby adding another reason for breastfeeding.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Aarhus, Aarhus, Denmark. ys@soci.au.dk
authors.forename: Yuelian
authors.initials: Y
authors.lastname: Sun
authors.forename: Mogens
authors.initials: M
authors.lastname: Vestergaard
authors.forename: Jakob
authors.initials: J
authors.lastname: Christensen
authors.forename: Jørn
authors.initials: J
authors.lastname: Olsen
mesh_terms: D001942:Breast Feeding; D015331:Cohort Studies; D003718:Denmark; D004827:Epilepsy / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D009035:Mothers; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012306:Risk; D012907:Smoking