title: Permeability study of vertebral cancellous bone using micro-computational fluid dynamics.
abstract: Understanding of cancellous bone permeability is lacking despite its importance in designing tissue engineering scaffolds for bone regeneration and orthopaedic surgery that relies on infiltration of bone cement into porous cancellous bone. We employed micro-computational fluid dynamics to investigate permeability for 37 cancellous bone specimens, eliminating stringent technical requirements of bench-top testing. Microarchitectural parameters were also determined for the specimens and correlated, using uni-variate and multi-variate regression analyses, against permeability. We determined that bone surface density, trabecular pattern factor, structure model index and trabecular number are other possible predictors of permeability (with R values of 0.47, 0.44, 0.40 and 0.33), in addition to the commonly used porosity parameter (R value of 0.38). Pooling these parameters and performing multi-variate linear regression analysis improved yield the R-value of 0.50, indicating that porosity alone is a poor predictor of cancellous bone permeability and, therefore, other parameters should be included for a better and improved linear model.
authors.affiliation: Biomat Lab, Faculty of Engineering, Department of Mechanical Engineering, National University of Singapore, E3-05-23, Engineering Drive 1, 10 Kent Ridge Crescent, Singapore 119260, Singapore. jem.teo@gmail.com
authors.forename: Jeremy C M
authors.initials: JC
authors.lastname: Teo
authors.forename: Swee Hin
authors.initials: SH
authors.lastname: Teoh
mesh_terms: D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D002102:Cadaver; D003198:Computer Simulation; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional; D066298:In Vitro Techniques; D016014:Linear Models; D008954:Models, Biological; D015999:Multivariate Analysis; D010539:Permeability; D016062:Porosity; D013131:Spine / Q000000981:diagnostic imaging / Q000502:physiology*; D055114:X-Ray Microtomography