title: Pandemic H1N1 influenza virus causes a stronger inflammatory response than seasonal H1N1 influenza virus in ferrets.
abstract: A 2009 H1N1 influenza virus pandemic, which had its origin in swine, caused severe illness and mortality in humans. Inflammatory responses may be responsible for pathogenesis caused by infection with influenza viruses. To better understand the pathogenic mechanism, clinical signs and inflammatory responses in ferrets infected with the pandemic H1N1 were compared with those caused by seasonal H1N1 influenza virus. Ferrets infected with the 2009 pandemic H1N1 virus displayed higher body temperatures, greater reduction in body weight, and higher viral titers in the tracheae and lungs. Levels of inflammatory cytokines, including interleukin-6, interferon-alpha, and tumor necrosis factor-alpha, were higher in the lungs of ferrets infected with the 2009 pandemic H1N1. The data support the idea that increased pathogenesis caused by the 2009 pandemic H1N1 influenza virus may have been partially mediated by a higher induction of pro-inflammatory cytokines in the lungs of affected humans or animals.
authors.affiliation: Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Gung Dong, Yuseong Gu, Daejeon, Korea.
authors.forename: Young Myong
authors.initials: YM
authors.lastname: Kang
authors.forename: Byung Min
authors.initials: BM
authors.lastname: Song
authors.forename: Joo Sub
authors.initials: JS
authors.lastname: Lee
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang Heui
authors.initials: SH
authors.lastname: Seo
mesh_terms: D000818:Animals; D001831:Body Temperature; D001835:Body Weight; D016207:Cytokines / Q000032:analysis; D004195:Disease Models, Animal; D005289:Ferrets; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification / Q000472:pathogenicity*; D008168:Lung / Q000473:pathology / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000821:virology*; D014132:Trachea / Q000821:virology
chemical_list: D016207:Cytokines