title: Vitamin D levels in children with recurrent tonsillitis.
abstract: OBJECTIVE
  Although recurrent tonsillitis can be the consequence of defects in immune system, the exact etiology of recurrent tonsillitis is not clear. In this study, our aim was to determine the serum vitamin D levels and vitamin D receptor polymorphism among children undergone tonsillectomy due to the recurrent tonsillitis.
  
  
  METHODS
  A 106 children undergone tonsillectomy due to recurrent tonsillitis and a 127 healthy children aging between 2 and 12 years were enrolled in this study, to determine serum 25-hydroxyvitamin D level and vitamin D receptor gene polymorphisms (Apa1, Taq 1, fok1). Serum vitamin D level was measured with ELISA (nmol/L) and receptor gene polymorphism was determined by PCR. Vitamin D serum level below 80nmol/L was accepted as insufficient.
  
  
  RESULTS
  The average serum vitamin D level was 176±79nmol/L in recurrent tonsillitis group and 193±56nmol/L in control group. There was no significant difference between the groups (p=0.13). In recurrent tonsillitis group, 18% (n=15) of children had their serum vitamin D levels below 80nmol/L. The vitamin D receptor gene polymorphism (APA1, TAQ 1, FOK 1) in each group was compared (AA, Aa, aa, TT, Tt, tt, FF, Ff, ff). There was no significant difference between the two groups. The vitamin D serum levels and receptor sub-genotypes are also compared, and there was no significant difference between the groups.
  
  
  CONCLUSIONS
  There is no difference between the serum vitamin D level and receptor gene polymorphism among children with recurrent tonsillitis and healthy children. But vitamin D insufficiency is more prevalent in children with recurrent tonsillitis group (18%).
authors.affiliation: Department of Otolaryngology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey. drsalihaydin@gmail.com
authors.forename: Salih
authors.initials: S
authors.lastname: Aydın
authors.forename: Ismet
authors.initials: I
authors.lastname: Aslan
authors.forename: Ismail
authors.initials: I
authors.lastname: Yıldız
authors.forename: Bedia
authors.initials: B
authors.lastname: Ağaçhan
authors.forename: Bahar
authors.initials: B
authors.lastname: Toptaş
authors.forename: Sadık
authors.initials: S
authors.lastname: Toprak
authors.forename: Kemal
authors.initials: K
authors.lastname: Değer
authors.forename: Mehmet Faruk
authors.initials: MF
authors.lastname: Oktay
authors.forename: Emin
authors.initials: E
authors.lastname: Unüvar
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D018167:Receptors, Calcitriol / Q000235:genetics*; D012008:Recurrence; D014068:Tonsillectomy; D014069:Tonsillitis / Q000097:blood* / Q000235:genetics* / Q000601:surgery; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D; C104450:25-hydroxyvitamin D