title: Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis.
abstract: Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups from lysine residues of histone proteins, a modification that results in epigenetic modulation of gene expression. Although originally shown to be involved in cancer and neurological disease, HDACs are also found to play crucial roles in arteriosclerosis. This review summarizes the effects of HDACs and HDAC inhibitors on proliferation, migration, and apoptosis of endothelial and smooth muscle cells. In addition, an updated discussion of HDACs' recently discovered effects on stem cell differentiation and atherosclerosis is provided. Overall, HDACs appear to be promising therapeutic targets for the treatment of arteriosclerosis and other cardiovascular diseases.
authors.affiliation: Cardiovascular Division, King's College London BHF Centre, 125 Coldharbour Lane, London SE5 9NU, UK.
authors.forename: Boda
authors.initials: B
authors.lastname: Zhou
authors.forename: Andriana
authors.initials: A
authors.lastname: Margariti
authors.forename: Lingfang
authors.initials: L
authors.lastname: Zeng
authors.forename: Qingbo
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000818:Animals; D017209:Apoptosis; D001161:Arteriosclerosis / Q000209:etiology*; D001808:Blood Vessels / Q000166:cytology* / Q000201:enzymology*; D002454:Cell Differentiation; D002465:Cell Movement; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D044127:Epigenesis, Genetic; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006655:Histone Deacetylases / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008955:Models, Cardiovascular; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000502:physiology; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000502:physiology
chemical_list: D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases