title: A mild and efficient palladium-catalyzed cyanation of aryl chlorides with K4[Fe(CN)6].
abstract: An efficient palladium-catalyzed cyanation of aryl chlorides is established. In the presence of a highly effective Pd/CM-phos catalyst, cyanation of aryl chlorides proceeds at 70 °C in general, which is the mildest reaction temperature achieved so far for this process. Common functional groups such as keto, aldehyde, ester, nitrile and -NH(2), and heterocyclic coupling partners including N-H indoles are well tolerated. Moreover, a sterically hindered nonactivated ortho,ortho-disubstituted electrophile is shown to be a feasible coupling partner in cyanation.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Pui Yee
authors.initials: PY
authors.lastname: Yeung
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.forename: Chak Po
authors.initials: CP
authors.lastname: Lau
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013696:Temperature
chemical_list: D006843:Hydrocarbons, Chlorinated; D009570:Nitriles; D010165:Palladium