title: Histopathological changes of rat kidney with exposure to chronic thinner inhalation.
abstract: BACKGROUND
  Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this study is to determine the histopathological changes of rat kidney with exposure to chronic thinner inhalation.
  
  
  METHODS
  Randomized trial--the study was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Forty albino Wistar male rats were used throughout the experiment. Three groups of rats inhaled thinner in a glass cage for 1, 3, and 5 weeks, respectively. Ten rats inhaled only the air in the room as the control group.
  
  
  RESULTS
  We observed the development of inflammation in the kidneys that became more remarkable as exposure time extended. Development of inflammation because of thinner apparently differed between the groups of week 1 and week 5. There was no difference in granuloma development. If the experiment lasted longer, there might have been granuloma development.
  
  
  CONCLUSIONS
  Based on histopathological evaluations, it was shown that exposure to chronic thinner inhalation causes detectable damage on the kidney, which becomes more prominent as exposure period extends. As we established disorders in movement and consciousness in the rats during thinner inhalation, we can conclude that thinner also has a damaging effect upon the central nervous system.
authors.affiliation: Department of Internal Diseases, Istanbul Education and Research Hospital, Istanbul, Turkey. aburaktoros@yahoo.com
authors.forename: Ahmet Burak
authors.initials: AB
authors.lastname: Toros
authors.forename: Sema Zer
authors.initials: SZ
authors.lastname: Toros
authors.forename: Fugen
authors.initials: F
authors.lastname: Aker
authors.forename: Feyzullah
authors.initials: F
authors.lastname: Ersoz
authors.forename: Abdullah
authors.initials: A
authors.lastname: Derin
authors.forename: Besir
authors.initials: B
authors.lastname: Kesici
authors.forename: Leyla
authors.initials: L
authors.lastname: Ozel
mesh_terms: D000818:Animals; D019570:Inhalation Exposure / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000009:adverse effects*
chemical_list: D012997:Solvents