title: Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.
abstract: The synthesis and the effect of a combination of 6-glycine and 14-phenylpropoxy substitutions in N-methyl- and N-cycloproplymethylmorphinans on biological activities are described. Binding studies revealed that all new 14-phenylpropoxymorphinans (11-18) displayed high affinity to opioid receptors. Replacement of the 14-methoxy group with a phenylpropoxy group led to an enhancement in affinity to all three opioid receptor types, with most pronounced increases in δ and κ activities, hence resulting in a loss of μ receptor selectivity. All compounds (11-18) showed potent and long-lasting antinociceptive effects in the tail-flick test in rats after subcutaneous administration. For the N-methyl derivatives 13 and 14, analgesic potencies were in the range of their 14-methoxy analogues 9 and 10, respectively. Even derivatives 15-18 with an N-cyclopropylmethyl substituent acted as potent antinociceptive agents, being several fold more potent than morphine. Subcutaneous administration of compounds 13 and 14 produced significant and prolonged antinociceptive effects mediated through peripheral opioid mechanisms in carrageenan-induced inflammatory hyperalgesia in rats.
authors.affiliation: Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria.
authors.forename: Mariana
authors.initials: M
authors.lastname: Spetea
authors.forename: Petra
authors.initials: P
authors.lastname: Windisch
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Indre
authors.initials: I
authors.lastname: Bileviciute-Ljungar
authors.forename: Johannes
authors.initials: J
authors.lastname: Schütz
authors.forename: Muhammad Faheem
authors.initials: MF
authors.lastname: Asim
authors.forename: Ilona P
authors.initials: IP
authors.lastname: Berzetei-Gurske
authors.forename: Pal
authors.initials: P
authors.lastname: Riba
authors.forename: Kornel
authors.initials: K
authors.lastname: Kiraly
authors.forename: Susanna
authors.initials: S
authors.lastname: Fürst
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Al-Khrasani
authors.forename: Helmut
authors.initials: H
authors.lastname: Schmidhammer
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009019:Morphinans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D034442:N-substituted Glycines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D009019:Morphinans; D034442:N-substituted Glycines; D011957:Receptors, Opioid; D016244:Guanosine 5'-O-(3-Thiotriphosphate)