title: Antipyretic effect of ibuprofen and dipyrone in febrile children.
abstract: OBJECTIVE
  To evaluate temperature changes in febrile children that received a single oral dose of ibuprofen (10 mg/kg), the dose recommended for high fever, or dipyrone (15 mg/kg), the dose recommended by the manufacturer, at 2, 3, 4, 5, 6, 7 and 8 hours after administration.
  
  
  METHODS
  This open-label randomized (1:1) controlled clinical tried enrolled 80 febrile boys and girls aged 6 months to 8 years with baseline axillary temperatures of 38.0 to 40.3 °C. The children were divided into two groups: high fever (> 39.1 °C) and low-grade fever (38.0 to 39.1 °C). The antipyretic effect was analyzed according to discontinuity, safety, response to treatment, tolerability and therapeutic efficacy.
  
  
  RESULTS
  Of the 80 children, 31 remained febrile during the 8 hours (38.8%), but 100% had a temperature decrease in the first 2 hours after the administration of either medication. In the high fever group, the temperature fell in 11 children treated with ibuprofen up to the 5th hour (100.00%) and in the 11 that received dipyrone, up to the third hour (100.00%). The difference in antipyretic efficacy of ibuprofen in the high fever group was statistically significant in the 3rd and 4th hours, and in the low-grade fever group, in the 3rd hour after medication.
  
  
  CONCLUSIONS
  A single oral dose of ibuprofen has a greater antipyretic efficacy than dipyrone, particularly when the fever is high. Both drugs were well tolerated and safe in the short term.
authors.affiliation: Faculdade de Ciências Médicas, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. anammagni@hotmail.com
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Magni
authors.forename: Daniel Kashiwamura
authors.initials: DK
authors.lastname: Scheffer
authors.forename: Paula
authors.initials: P
authors.lastname: Bruniera
mesh_terms: D000284:Administration, Oral; D058633:Antipyretics / Q000008:administration & dosage* / Q000009:adverse effects; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D004177:Dipyrone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage* / Q000009:adverse effects; D007223:Infant; D008297:Male; D016896:Treatment Outcome
chemical_list: D058633:Antipyretics; D004177:Dipyrone; D007052:Ibuprofen