title: [Effect of hypothermia on activities of tubule motor protein and constructure protein after cerebral ischemia in gerbils].
abstract: OBJECTIVE
  To study the effect of hypothermia on kinesin and MAP2 activities after cerebral ischemia in gerbils, and investigate the relationship between changes of their activities and DND.
  
  
  METHODS
  Immunoreactivity of kinesin and MAP2 were determined by immunohistochemical study in combination with computer image analysis system, and DND were assayed by histological examination.
  
  
  RESULTS
  Hypothermia significantly reduced DND after cerebral ischemia. Immunoreactivities of MAP2 and kinesin progressively decreased during forebrain ischemia-reperfusion, and the decreasing of kinesin activity was greater than that of MAP2 in the same reperfusion time. Hypothermia obviously mitigate the decreasing degree of MAP2 and kinesin activity after cerebral ischemia. The decreasing degree of kinesin activity was consistent with that of DND during cerebral ischemia/reperfusion in gerbils.
  
  
  CONCLUSIONS
  Hypothermia significantly reduced DND after cerebral ischemia, which might be related to the improvement of kinesin activity after cerebral ischemia reperfusion in gerbils.
authors.affiliation: Department of Anesthesiology, Jiangsu Provincial Key Laboratory of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xuchou 221002, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: Y M
authors.initials: YM
authors.lastname: Zeng
authors.forename: W D
authors.initials: WD
authors.lastname: Gu
authors.forename: J G
authors.initials: JG
authors.lastname: Wang
authors.forename: J W
authors.initials: JW
authors.lastname: Fan
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D016923:Cell Death; D005849:Gerbillinae; D007035:Hypothermia; D016547:Kinesins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009474:Neurons / Q000166:cytology*
chemical_list: D008869:Microtubule-Associated Proteins; D016547:Kinesins