title: Mechanism and significance of cis-inhibition in Notch signalling.
abstract: Notch receptors in a given cell are activated by cell surface ligands in neighbouring cells but can also be inhibited by the ligands present within the same cell. This process is known as cis-inhibition of Notch. Additionally, reciprocal cis-inhibition of the ligands by Notch has also been observed, albeit to a limited extent. Here, we review the mechanisms, functional relevance and potential implications of these cis-inhibitory interactions for Notch-mediated fate decisions.
authors.affiliation: Institut Pasteur, Dépt. Biologie du Développement, F-75015 Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: del Álamo
authors.forename: Hervé
authors.initials: H
authors.lastname: Rouault
authors.forename: François
authors.initials: F
authors.lastname: Schweisguth
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch