title: Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate.
abstract: This communication describes the design of a novel and general bioresponsive controlled-release mesoporous silica (MS) nanoparticles system based on aptamer-target interactions. In this system, the pores of MS were capped with Au nanoparticles modified with aptamer (ATP aptamer in this case). By a competitive displacement reaction, the Au nanoparticles were uncapped in the presence of ATP molecule, and the cargo was released. Our results demonstrated that the aptamer-target interaction may be a promising route for the design of custom-made controlled-release nanodevices specifically governed by target biomolecules. Since aptamers have been obtained for a broad range of targets, including several cancer biomarkers, we believe that this aptamer-based controlled-release system should have an equally broad spectrum of applications.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, PR China.
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Zhu
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Song
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
authors.forename: Xiao-Ru
authors.initials: XR
authors.lastname: Wang
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D052157:Aptamers, Nucleotide / Q000737:chemistry* / Q000378:metabolism*; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D052157:Aptamers, Nucleotide; D006046:Gold; D012822:Silicon Dioxide; D000255:Adenosine Triphosphate