title: Gluten sensitivity: associated sporadic cerebellar ataxia in Taiwan.
abstract: OBJECTIVE
  Gluten sensitivity (GS) is related to the pathogenesis of sporadic or hereditary ataxia.
  
  
  METHODS
  Total of 194 healthy controls and patients with either hereditary ataxia (n=207) or sporadic ataxia (n=361) were tested for the circulating gluten-related autoantibodies which serve as biomarkers to interpret the existence of GS.
  
  
  RESULTS
  The incidences of GS in each population were 1% in normal subjects, 2% in hereditary ataxia patients and 9% in sporadic ataxia patients. High serum level of anti-gliadin IgG/IgA and t-transglutaminase IgA were disclosed at the sporadic ataxia patients compared with normal subjects. However, the anti-gliadin IgG is more specific to the disease of sporadic ataxia.
  
  
  CONCLUSIONS
  Relatively higher incidence of GS was found in the population of sporadic ataxia patients but not in either normal subjects or hereditary ataxia patients in Taiwan. Anti-gliadin IgG still is a very powerful indicator to implicate the immune-related sporadic ataxia and we conclude that GS-related sporadic ataxia exists in Taiwan with linkage to autoimmune events.
authors.affiliation: Department of Neurology, Vascular and Genomics Center, Changhua Christian Hospital, No. 135, Nanhsiao Street, Changhua 500, Taiwan. 26602@cch.org.tw
authors.forename: Chin-San
authors.initials: CS
authors.lastname: Liu
authors.forename: Bing-Wen
authors.initials: BW
authors.lastname: Soong
authors.forename: Yi-Chung
authors.initials: YC
authors.lastname: Lee
authors.forename: Woan-Ling
authors.initials: WL
authors.lastname: Chen
authors.forename: Chen-Ling
authors.initials: CL
authors.lastname: Kuo
authors.forename: Wen-Ling
authors.initials: WL
authors.lastname: Cheng
authors.forename: Ching-Shan
authors.initials: CS
authors.lastname: Huang
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002524:Cerebellar Ataxia / Q000453:epidemiology / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin