title: [Locally advanced pancreatic cancer successfully treated by arterial infusion chemotherapy combined with stereotactic radiotherapy--a case report].
abstract: We report a 60-year-old female with locally advanced pancreatic cancer successfully treated with stereotactic radiotherapy after arterial chemoinfusion. Using the indwelling catheter-port system with the unification of the pancreatic blood supply, we initially conducted an arterial infusion of weekly high-dose 5-FU (1,000 mg/m2/qw) combined with systemic gemcitabine (1,000 mg/m2/qw). As a result, the tumor was remarkably decreased. However, a part of the tumor where the drug had not been distributed remained in no reduction. Therefore, we added the stereotactic radiotherapy (50 Gy) targeted on the limited residual tumor and combined with concurrent systemic gemcitabine (1,000 mg/m2/qw). The residual tumors have been controlled well without distant metastases, and the patient is alive today 36 months after our initial treatment.
authors.affiliation: Dept. of Radiology, Nara Medical University.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nishiofuku
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Anai
authors.forename: Satoru
authors.initials: S
authors.lastname: Sueyoshi
authors.forename: Kiyosei
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Kengo
authors.initials: K
authors.lastname: Morimoto
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Maeda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Masada
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sho
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Tamamoto
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kichikawa
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000628:therapy*; D016634:Radiosurgery / Q000379:methods*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine