title: The effect of decreasing renal function on lipoprotein profiles.
abstract: BACKGROUND
  Progressive chronic kidney disease (CKD) is accompanied by dyslipidemia that is characterized by increased concentrations of intact and partially metabolized ApoB and ApoC-III-containing triglyceride-rich lipoproteins in very low-density lipoprotein, intermediate density lipoprotein (IDL) and low-density lipoprotein. The purpose of the present study was to characterize the distribution of individual discrete lipoprotein subclasses in relation to the glomerular filtration rate (GFR) in nondiabetic CKD subjects.
  
  
  METHODS
  Fifty-one subjects (33 patients with CKD and 18 asymptomatic subjects) with GFR ranging from 12 to 120 mL/min were studied. Individual ApoA- and ApoB-containing lipoprotein subclasses (Lp) were determined in plasma by sequential immunoaffinity chromatography and subsequent determination of apolipoprotein composition by electroimmunoassays. GFR was measured as plasma clearance of iohexol or (51)Cr-ethylenediaminetetraacetic acid.
  
  
  RESULTS
  There were no changes in concentrations of ApoA-containing lipoproteins with decreasing GFR. The levels of ApoB-containing lipoproteins increased significantly with decreasing GFR. There was a moderate increase of cholesterol-rich LpB and a 3-fold increase of ApoB- and ApoC-III-containing lipoproteins in subjects in the two lowest quintiles of GFR. This was accompanied by a significant increase of plasma ApoC-III.
  
  
  CONCLUSIONS
  Reduced renal function is associated with a complex alteration of the lipoprotein profile that is predominantly characterized by increased concentrations of triglyceride-rich lipoprotein subclasses containing both ApoB and ApoC-III.
authors.affiliation: Department of Nephrology, Sahlgrenska University Hospital, Göteborg, Sweden. per-ola.attman@vgregion.se
authors.forename: Per-Ola
authors.initials: PO
authors.lastname: Attman
authors.forename: Ola
authors.initials: O
authors.lastname: Samuelsson
authors.forename: Petar
authors.initials: P
authors.lastname: Alaupovic
mesh_terms: D002846:Chromatography, Affinity; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007118:Immunoassay; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D007677:Kidney Function Tests; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D008074:Lipoproteins