title: Introduction to biodegradable polylactic acid ureteral stent application for treatment of ureteral war injury.
abstract: OBJECTIVE
  • To study the operability and effectiveness of a biodegradable ureteral stent for clinical treatment of ureteral war injury using a canine model.
  
  
  METHODS
  • A device was designed and employed to generate firearm fragment wounds in unilateral ureters (on randomly chosen sides) of nine beagles (Group A). The wounded ureters were then debrided and sutured. • Intravenous pyelography (IVP) and radioactive renography were performed 40, 80 and 120 days postoperatively. In Group B, firearm fragment wounds were made to the bilateral ureters in nine beagles. A polylactic acid stent was placed unilaterally (on a randomly chosen side) whereas the ureter on the other side was debrided and sutured without stenting. • Both IVP and radioactive renography were performed 40, 80 and 120 days postoperatively. The operability and effectiveness of the biodegradable ureteral stent were studied thereafter.
  
  
  RESULTS
  • In Group A, hydronephrosis and hydroureter occurred and worsened postoperatively on the wounded sides in all nine beagles. The ratio of the renal partial concentration indices (RPCI) between the kidneys (unwounded side : wounded side) increased. • The ratio of the kidney washout half-time between the kidneys (unwounded side : wounded side) decreased. In Group B, neither hydronephrosis nor hydroureter was found postoperatively in the stented ureters but both occurred in the unstented ureters in all nine beagles. • The ratio of RPCI between kidneys (stented side : unstented side) increased whereas the kidney washout half-time ratio between the stented and unstented sides decreased. Differences were significant.
  
  
  CONCLUSIONS
  • In Group A, the new canine model for firearm fragment wounds was tested and proved to be operable and effective. In Group B, hydronephrosis and hydroureter were effectively prevented in ureters by biodegradable stent placement compared with the non-stented ureters where hydronephrosis and hydroureter occurred. The renal concentration capacity was effectively protected and the half-time of kidney washout was shortened.
authors.affiliation: Department of Urology, The General Hospital of PLA, Beijing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Zhong-Xin
authors.initials: ZX
authors.lastname: Wang
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Fu
authors.forename: Bao-Fa
authors.initials: BF
authors.lastname: Hong
authors.forename: Xiao-Xiong
authors.initials: XX
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Song
authors.forename: Fu-Zhai
authors.initials: FZ
authors.lastname: Cui
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004285:Dogs; D005240:Feasibility Studies; D005260:Female; D006869:Hydronephrosis / Q000517:prevention & control; D019344:Lactic Acid / Q000627:therapeutic use*; D008297:Male; D011091:Polyesters; D011108:Polymers / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D011859:Radiography; D015607:Stents; D014513:Ureter / Q000000981:diagnostic imaging / Q000293:injuries*; D014515:Ureteral Diseases / Q000517:prevention & control; D014857:Warfare; D014948:Wounds, Gunshot / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)