title: Experimental model of combined pain and depression status in rats.
abstract: Combined pain and depression status in rats was created by inducing experimental depressive syndrome (by subchronic injection of MPTP proneurotoxin) in animals with manifest and developing neurogenic pain syndrome induced by preliminary crossing of the sciatic nerve in the hind limb. The neurogenic pain syndrome augmented by some parameters the depressive symptoms and provoked manifestation of signs of depressive behavior in animals treated with saline.
authors.affiliation: Laboratory of Nervous System General Pathology, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. krupinana@yandex.ru
authors.forename: N A
authors.initials: NA
authors.lastname: Krupina
authors.forename: N N
authors.initials: NN
authors.lastname: Khlebnikova
authors.forename: I N
authors.initials: IN
authors.lastname: Orlova
authors.forename: V N
authors.initials: VN
authors.lastname: Grafova
authors.forename: V S
authors.initials: VS
authors.lastname: Smirnova
authors.forename: V I
authors.initials: VI
authors.lastname: Rodina
authors.forename: M L
authors.initials: ML
authors.lastname: Kukushkin
authors.forename: G N
authors.initials: GN
authors.lastname: Kryzhanovsky
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001007:Anxiety / Q000209:etiology; D019771:Axotomy; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000139:chemically induced*; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D023421:Models, Animal; D009043:Motor Activity / Q000187:drug effects; D010146:Pain; D051381:Rats; D017208:Rats, Wistar; D020426:Sciatic Neuropathy / Q000150:complications*
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine