title: Implication of oncogenic signaling pathways as a treatment strategy for neurodegenerative disorders - contemporary approaches.
abstract: Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal cell vulnerability in Alzheimer's and Parkinson's diseases, as a common chronic neurodegeneration. This phenomenon associated with oncogenic transduction pathway activation has attracted the interest of scientists all over the world for a few years now. The purpose of this paper is to outline areas of research related to oncogenic factors or medicines in the context of potential applications for future treatment of the above mentioned chronic and, largely, incurable diseases.
authors.affiliation: Department of Neurology, Faculty of Health Science, Wroclaw Medical University, 5 K. Bartla Str., 51-618 Wroclaw, Poland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Sieradzki
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Yendluri
authors.forename: Hector H
authors.initials: HH
authors.lastname: Palacios
authors.forename: Kalpana
authors.initials: K
authors.lastname: Parvathaneni
authors.forename: V Prakash
authors.initials: VP
authors.lastname: Reddy
authors.forename: Mark E
authors.initials: ME
authors.lastname: Obrenovich
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Gąsiorowski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszek
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism*; D002453:Cell Cycle; D006801:Humans; D009410:Nerve Degeneration / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D015513:Oncogene Proteins / Q000378:metabolism*; D009857:Oncogenes; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D028861:Nuclear Pore Complex Proteins; D015513:Oncogene Proteins