title: The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
abstract: The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.
authors.affiliation: Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Wilmarie
authors.initials: W
authors.lastname: Flores-Santana
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Salmon
authors.forename: Sonia
authors.initials: S
authors.lastname: Donzelli
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Switzer
authors.forename: Debashree
authors.initials: D
authors.lastname: Basudhar
authors.forename: Lisa
authors.initials: L
authors.lastname: Ridnour
authors.forename: Robert
authors.initials: R
authors.lastname: Cheng
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Glynn
authors.forename: Nazareno
authors.initials: N
authors.lastname: Paolocci
authors.forename: Jon M
authors.initials: JM
authors.lastname: Fukuto
authors.forename: Katrina M
authors.initials: KM
authors.lastname: Miranda
authors.forename: David A
authors.initials: DA
authors.lastname: Wink
mesh_terms: D000818:Animals; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism; D009589:Nitrogen Oxides / Q000737:chemistry / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism
chemical_list: D008667:Metalloproteins; D009589:Nitrogen Oxides; D013438:Sulfhydryl Compounds; C039900:nitroxyl