title: The connexin 37 (1019C>T) gene polymorphism is associated with subclinical atherosclerosis in women with type 1 and 2 diabetes and in women with central obesity.
abstract: The gene for connexin 37 (Cx37) is considered to be one of the candidate genes for cardiovascular disease. We evaluated the association between Cx37 (1019C>T) gene polymorphism (Pro319Ser) and ankle brachial blood pressure index (ABI) in women with type 1 (n=178) and type 2 (n=111) diabetes, and in women from general population (n=862). All women were genotyped for Cx37 polymorphism. In addition to traditional cardiovascular risk factors, ABI was analyzed. In women with type 1 diabetes, ABI significantly decreased from TT to CC carriers (p for trend = 0.008). A similar trend was seen in women with type 2 diabetes (p = 0.050) and in women with waist circumference above 75th percentile (94 cm; n=208) of the general population (p = 0.049). The gene for Cx37 was associated with subclinical atherosclerosis in women with type 1 and 2 diabetes and in women with advanced central obesity. The presence of C allele indicated increased risk.
authors.affiliation: Laboratory for Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. japi@medicon.cz
authors.forename: J
authors.initials: J
authors.lastname: Piťha
authors.forename: J A
authors.initials: JA
authors.lastname: Hubáček
authors.forename: P
authors.initials: P
authors.lastname: Piťhová
mesh_terms: D050197:Atherosclerosis / Q000235:genetics*; D017630:Connexins / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D000097006:Gap Junction alpha-4 Protein
chemical_list: D017630:Connexins; D000097006:Gap Junction alpha-4 Protein