title: [Prospective clinic study of decreasing the rate of missed diagnosis of endometrial cancer].
abstract: OBJECTIVE
  to analyze the clinical significance of a novel operating approach of cutting the core of uterus to perform freezing section histological examination intra-operatively for the patients with endometrial hyperplasia (EH).
  
  
  METHODS
  the patients ready to undergo total hysterectomy with a histological diagnosis of EH were selected. In the cutting core group (n = 39), the core of uterus was resected firstly according to the freezing histological diagnosis. Thirty cases received hysteroscopy with directed biopsies while the control group had 57 cases. Their differences of missed diagnosis rate of endometrial cancer and operative approaches were compared. And the clinic significance of cutting firstly the core of uterus intra-operatively was discussed.
  
  
  RESULTS
  in the cutting core, hysteroscopy with directed biopsies and control groups, the missed diagnosis rate was 2.6%, 3.3% and 14.0% respectively. The missed diagnosis rate of first two groups had significant difference as compared with the controls (χ(2) = 4.78, P < 0.05; χ(2) = 4.73, P < 0.05).
  
  
  CONCLUSIONS
  the novel operating approach can effectively prevent the missed diagnosis of endometrial cancer. It helps a surgeon to choose suitable operative extent for the patients with endometrial hyperplasia.
authors.affiliation: Department of Gynecology, Second Hospital, Shandong University, Jinan 250033, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Gang
authors.initials: G
authors.lastname: Xin
authors.forename: Juan
authors.initials: J
authors.lastname: DU
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D016616:Cryoultramicrotomy; D003951:Diagnostic Errors; D004714:Endometrial Hyperplasia / Q000175:diagnosis / Q000473:pathology; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies