title: Strong ion reserve: a viewpoint on acid base equilibria and buffering.
abstract: Evidence suggests that strong ions can exist reversibly bound to proteins in a pH-dependent manner and that they can be recruited into the biological solution, modulating its strong ion difference in a process that opposes the acid base disturbances imposed on the system. These recruitable strong ions represent the solution's 'strong ion reserve'. The physiologic [corrected] role of these protein-bound strong ions [corrected] in the buffering of acid base disorders is discussed.
authors.affiliation: Second Department of Intensive Care Medicine, "Georgios Papanikolaou" General Hospital of Thessaloniki, 57010, Exochi, Greece. m.agrafiotis@gmail.com
authors.forename: Michalis
authors.initials: M
authors.lastname: Agrafiotis
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D002021:Buffers; D056246:Chemistry, Analytic; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry / Q000494:pharmacology*; D008962:Models, Theoretical; D009994:Osmolar Concentration; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology; D012106:Research; D012996:Solutions
chemical_list: D002021:Buffers; D007477:Ions; D011506:Proteins; D012996:Solutions