title: Therapeutic efficacy of halocidin-derived peptide HG1 in a mouse model of surgical wound infection with methicillin-resistant Staphylococcus aureus.
abstract: We evaluated the therapeutic potential of HG1, an antimicrobial peptide, as a novel topical antibiotic by the use of a mouse surgical wound model of infection with methicillin-resistant Staphylococcus aureus. First, we attempted to determine whether or not HG1 infiltrated into the dermis when topically administered. Second, we evaluated the antibiotic effects of HG1 on skin infection via bacterial-enumeration and microscopic analyses. The results showed that topically administered HG1 was capable of penetrating into the dermis at the infection site, where it exerted its antimicrobial effects.
authors.affiliation: Department of Biotechnology, Hoseo University, Asan City, Chungnam, South Korea.
authors.forename: Young Shin
authors.initials: YS
authors.lastname: Lee
authors.forename: Yong Pyo
authors.initials: YP
authors.lastname: Shin
authors.forename: Seo Hwa
authors.initials: SH
authors.lastname: Shin
authors.forename: Seungmi
authors.initials: S
authors.lastname: Park
authors.forename: Myung Hwa
authors.initials: MH
authors.lastname: Kim
authors.forename: In Hee
authors.initials: IH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity*; D051379:Mice; D010455:Peptides / Q000737:chemistry* / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; C460842:halocidin