title: Gender difference in prevalence and prognostic impact of renal insufficiency in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention.
abstract: OBJECTIVE
  To evaluate if female gender is associated with renal insufficiency in patients with ST-elevation myocardial infarction (STEMI) and if there is a gender difference in the prognostic importance of renal insufficiency in STEMI.
  
  
  METHODS
  Single-centre observational study.
  
  
  METHODS
  One tertiary cardiac centre.
  
  
  METHODS
  All consecutive patients with STEMI planned for primary percutaneous coronary intervention in one Swedish county in 2005 (98 women and 176 men).
  
  
  METHODS
  Logistic regression analyses were conducted to evaluate the predictors of renal insufficiency, associations between estimated glomerular filtration rate (eGFR) and outcome in each gender and a possible interaction between gender and eGFR regarding outcome.
  
  
  RESULTS
  Renal insufficiency was defined as eGFR less than 60 ml/min per 1.73 m(2). 67% of women had renal insufficiency compared with 26% of men, OR 5.06 (95% CI 2.66 to 9.59) after multivariable adjustment. In women each 10 ml/min per 1.73 m(2) increment of eGFR was associated with a 63% risk reduction for 1-year mortality, OR 0.37 (95% CI 0.15 to 0.89). No such association was found in men, OR 1.05 (95% CI 0.63 to 1.76). A trend towards a significant interaction between gender and eGFR regarding 1-year mortality was found, OR 2.05 (95% CI 0.93 to 4.50).
  
  
  CONCLUSIONS
  A considerable gender difference in the prevalence of renal insufficiency in STEMI was found and renal insufficiency seemed to be a more important prognostic marker in women. These results are important as previous STEMI studies have shown higher multivariable adjusted mortality in women than in men but renal function has seldom been taken into consideration.
authors.affiliation: Department of Medical and Health Sciences, Division of Cardiovascular Medicine, Linko¨ping University Hospital, Linko¨ping, Sweden. sofia.lawesson@liu.se
authors.forename: Sofia
authors.initials: S
authors.lastname: Sederholm Lawesson
authors.forename: Tim
authors.initials: T
authors.lastname: Tödt
authors.forename: Joakim
authors.initials: J
authors.lastname: Alfredsson
authors.forename: Magnus
authors.initials: M
authors.lastname: Janzon
authors.forename: Ulf
authors.initials: U
authors.lastname: Stenestrand
authors.forename: Eva
authors.initials: E
authors.lastname: Swahn
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000401:mortality*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology; D012737:Sex Factors; D016896:Treatment Outcome