title: Ovarian reserve and oocyte maturity in women with malignancy undergoing in vitro maturation treatment.
abstract: OBJECTIVE
  To evaluate ovarian reserve and oocyte maturity in women with malignancy.
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  We evaluated all women with malignancy who underwent in vitro maturation treatment for fertility preservation from the year 2003 to 2009. The results were compared with those of an age-matched infertile control group.
  
  
  METHODS
  In vitro maturation treatment.
  
  
  METHODS
  Ovarian reserve and oocyte maturity.
  
  
  RESULTS
  Women with malignancy of the breast (n = 87), hematologic malignancy (n = 16), gynecologic or abdominal malignancy (n = 9), and other malignancies (n = 16) were compared with infertile control women (n = 79). The age was similar in all groups except in women with hematologic malignancy where they were younger than the control group (24.9 ± 1.1 years vs. 30.8 ± 0.4 years, confidence interval 4.0-9.5). Baseline FSH in this group was also lower than in the control group. Women with breast cancer had a lower number of retrieved oocytes than the control group (95% confidence interval 0-5). There were no significant differences in antral follicle count, percentage of mature oocytes on collection day, and percentage of metaphase II oocytes matured in vitro among all groups of women.
  
  
  CONCLUSIONS
  Women with breast cancer have fewer numbers of retrieved oocytes than infertile controls. Ovarian reserve and oocyte maturity in other types of malignancy are similar to those in the control group.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: Anwar
authors.initials: A
authors.lastname: Moria
authors.forename: Mausumi
authors.initials: M
authors.lastname: Das
authors.forename: Fady
authors.initials: F
authors.lastname: Shehata
authors.forename: Hananel
authors.initials: H
authors.lastname: Holzer
authors.forename: Weon-Young
authors.initials: WY
authors.lastname: Son
authors.forename: Togas
authors.initials: T
authors.lastname: Tulandi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002452:Cell Count; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D009369:Neoplasms / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D009865:Oocytes / Q000473:pathology* / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology*; D010053:Ovary / Q000473:pathology*; D027724:Reproductive Techniques, Assisted; D055815:Young Adult