title: Re: Designing a randomized clinical trial to evaluate personalized medicine: a new approach based on risk prediction.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Simon
authors.forename: Boris
authors.initials: B
authors.lastname: Freidlin
mesh_terms: D015982:Bias; D006801:Humans; D057285:Precision Medicine; D011237:Predictive Value of Tests; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome