title: The evolutionary history of calreticulin and calnexin genes in green plants.
abstract: Calreticulin and calnexin are Ca(2+)-binding chaperones localized in the endoplasmic reticulum of eukaryotes acting in glycoprotein folding quality control and Ca(2+) homeostasis. The evolutionary histories of calreticulin and calnexin gene families were inferred by comprehensive phylogenetic analyses using 18 completed genomes and ESTs covering the major green plants groups, from green algae to angiosperms. Calreticulin and calnexin possibly share a common origin, and both proteins are present along all green plants lineages. The calreticulin founder gene within green plants duplicated in early tracheophytes leading to two possible groups of orthologs with specialized functions, followed by lineage-specific gene duplications in spermatophytes. Calnexin founder gene in land plants was inherited from basal green algae during evolution in a very conservative copy number. A comprehensive classification in possible groups of orthologs and a catalog of calreticulin and calnexin genes from green plants are provided.
authors.affiliation: Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas, Av. Cândido Rondon 400-Cidade Universitária, Campinas,Brazil. lev.del.bem@gmail.com
authors.forename: Luiz Eduardo V
authors.initials: LE
authors.lastname: Del Bem
mesh_terms: D002135:Calcium-Binding Proteins / Q000378:metabolism; D037281:Calnexin / Q000378:metabolism*; D037282:Calreticulin / Q000378:metabolism*; D019143:Evolution, Molecular; D020224:Expressed Sequence Tags; D018703:Founder Effect; D018628:Gene Dosage; D020440:Gene Duplication; D018745:Genome, Plant; D018832:Molecular Chaperones; D010802:Phylogeny; D057948:Viridiplantae / Q000235:genetics*
chemical_list: D002135:Calcium-Binding Proteins; D037282:Calreticulin; D018832:Molecular Chaperones; D037281:Calnexin