title: New insight into A₁ adenosine receptors in diabetes treatment.
abstract: The A₁ adenosine receptors (A₁AR), belonging to the rhodopsin-like superfamily of the G-protein-coupled receptors (GPCRs), may regulate many various cellular processes in cardiovascular, renal, and central nervous systems. In addition, since A(1)AR possesses antilipolytic properties, numerous A₁AR agonists and antagonists have been developed, but only some of them with the most promising selective properties in vitro have been advanced to animal studies and clinical trials. In this review, we have summarized the studies on the utility of A₁AR selective agonists and antagonists in the regulation of lipid and carbohydrate metabolism and their potential therapeutic applications in diabetes.
authors.affiliation: Department of Structural Biology, Medical University of Lodz, 7/9 Zeligowskiego St., 90-752 Lodz, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Wojcik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Zieleniak
authors.forename: Lucyna A
authors.initials: LA
authors.lastname: Wozniak
mesh_terms: D058907:Adenosine A1 Receptor Agonists / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D058916:Adenosine A1 Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D050260:Carbohydrate Metabolism / Q000187:drug effects; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D043682:Receptor, Adenosine A1 / Q000502:physiology*
chemical_list: D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D043682:Receptor, Adenosine A1