title: The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia.
abstract: A total of 934 patients with schizophrenia and 433 controls were genotyped for the interleukin-10 (IL-10) promoter and DRD4 uVNTR polymorphisms. DRD4 long-form variants (namely, those with ≥5 repeats), homozygosity for the 4-repeat allele, and the IL-10 haplotype ACA were associated with schizophrenia, respectively. No obvious interactions among the potential polymorphisms were found, which suggests that IL-10 and DRD4 confer vulnerability to schizophrenia independently.
authors.affiliation: Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan. forwey@seed.net.tw
authors.forename: For-Wey
authors.initials: FW
authors.lastname: Lung
authors.forename: Ming-Chang
authors.initials: MC
authors.lastname: Yang
authors.forename: Bih-Ching
authors.initials: BC
authors.lastname: Shu
mesh_terms: D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D008957:Models, Genetic; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D013624:Taiwan
chemical_list: C493599:DRD4 protein, human; C508609:IL10 protein, human; D016753:Interleukin-10; D050638:Receptors, Dopamine D4