title: [Toxic epidermal necrolysis treated with cyclosporin A].
abstract: Lyell's syndrome or toxic epidermal necrolysis (TEN) is an extremely rare and dangerous severe skin disorder characterized by a high proportion of cutaneous lesions leading to necrosis and subsequent shedding of the epidermis over large areas of skin after an idiosyncratic reaction triggered by a drug. The patients who suffer it pathophysiologically have similar complications to those seen in major burns. TEN traditionally has been treated with immunomodulators such as glucocorticoids, intravenous gammaglobulin, cyclophosphamide, thalidomide or plasmapheresis. A variable, and sometimes contradictory response, has been obtained in some series. Cyclosporin A has been tested as a single immunomodulator in patients with TEN since the end of the 90 s in a limited number series. The results have improved in regards to survival compared with studies with other drugs. We report three consecutive cases of toxic epidermal necrolysis treated with cyclosporin A in this article.
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Universitario San Cecilio, Granada, España. afernandezcarmona@Hotmail.com
authors.forename: A Fernández
authors.initials: AF
authors.lastname: Carmona
authors.forename: A Díaz
authors.initials: AD
authors.lastname: Redondo
authors.forename: L Olivencia
authors.initials: LO
authors.lastname: Peña
authors.forename: A Garzón
authors.initials: AG
authors.lastname: Gómez
authors.forename: J Carlos Frías
authors.initials: JC
authors.lastname: Pareja
authors.forename: J L Ballesteros
authors.initials: JL
authors.lastname: Martínez
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000009:adverse effects; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000209:etiology
chemical_list: D007155:Immunologic Factors; D000493:Allopurinol; D019980:Amoxicillin-Potassium Clavulanate Combination; D016572:Cyclosporine