title: [Clinical study of combined chemotherapy of domestic paclitaxel and vinorelbine plus platinum for advanced non-small cell lung cancer].
abstract: BACKGROUND
  To evaluate the efficacy and toxicity of combined chemotherapy of domestic paclitaxel and vinorelbine plus cisplatin and carboplatin in the treatment of advanced non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A total of 181 initially treated patients with advanced NSCLC were enrolled in this study and treated by NP (vinorelbine plus cisplatin), TC (domestic paclitaxel plus carboplatin) and TP (domestic paclitaxel plus cisplatin). The efficacy and side effects were analysed after at least two cycles of chemotherapy.
  
  
  RESULTS
  The overall response rates (CR+PR) were 42.4% in the NP arm, 40.3% in the TC arm and 43.3% in the TP arm respectively. No significant statistical difference was found among the three groups ( Chi-square= 0.108 6 , P > 0.05). The median survival times were 8.4 months, 9.4 months and 8.9 months respectively in the NP, TC and TP groups ( P > 0.05). The 1-, 2-, 3-year survival rates were 39.0%, 16.9%, 5.1% in the NP group and 41.9%, 21.0%, 6.5% in the TC group and 40.0%, 18.3%, 5.0% in the TP group respectively. No significant statistical difference was found among the three groups ( Chi-square=0.140 4, P > 0.05). The major side effects were myelosuppression, alopecia and nausea/vomiting in the three groups. There were no chemotherapy-related death among the three groups.
  
  
  CONCLUSIONS
  The combined regimens of NP, TC and TP are effective and well-tolerated regimens for advanced NSCLC.
authors.affiliation: Department of Oncology, Beijing Thoracic Tumor Hospital, Beijing 101149, P.R.China.
authors.forename: Shucai
authors.initials: S
authors.lastname: Zhang
authors.forename: Xinjie
authors.initials: X
authors.lastname: Yang
authors.forename: Fanbin
authors.initials: F
authors.lastname: Hu
authors.forename: Qunhui
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Fan
authors.forename: Jinghui
authors.initials: J
authors.lastname: Wang
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Gu
authors.forename: Haiyong
authors.initials: H
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Xi
authors.initials: X
authors.lastname: Li