title: Design, synthesis and preliminary evaluation of novel imperatorin derivatives as vasorelaxant agents.
abstract: A series of novel imperatorin derivatives were synthesized from commercially available xanthotoxin. The in vitro pharmacological evaluation indicated that all of the compounds possessed potent vasodilatory activity. Among them, compounds (5b), (5d) and (5e) exhibited higher vasdilatory activity (with EC(50) values of 0.68 µM, 0.59 µM and 0.49 µM, respectively) than imperatorin (EC(50) = 1.12 µM). The program Volsurf was used to predict the derivatives' ADME-relevant descriptors. The results suggested that these novel compounds had a potential interest for the development of novel and potent vasorelaxant agents.
authors.affiliation: College of Medicine, Xi'an Jiaotong University, No. 76, Yanta Weststreet, Xi'an, Shaanxi Province, 710061, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Jianyu
authors.initials: J
authors.lastname: He
authors.forename: Yingzhuan
authors.initials: Y
authors.lastname: Zhan
authors.forename: Nan
authors.initials: N
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D018938:Caco-2 Cells; D015195:Drug Design; D011564:Furocoumarins / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008730:Methoxsalen / Q000031:analogs & derivatives*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012984:Software; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D011564:Furocoumarins; D014665:Vasodilator Agents; C031534:imperatorin; D008730:Methoxsalen