title: Anti pseudorabies virus activity of kumazasa extract.
abstract: Sasa veitchii or "kumazasa" has been used for the preservation of food, or preventing bacterial activity. However, the antiviral activity of kumazasa is poorly understood. In the present study, the antiviral activity of kumazasa extract (KE) was assessed by the plaque reduction assay for the pseudorabies virus (PRV). KE reduced 99% of the plaque formation of PRV at concentrations of 1.2%, showing that KE inhibited PRV adsorption to cells and IE180 expression. The polysaccharide fraction of KE showed a concentration dependent inhibition of PRV plaque formation. We conclude that KE possesses potent anti PRV activity, and the candidate responsible for the antiviral property was the polysaccharide fraction.
authors.affiliation: Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima, Kagoshima, University, Japan
authors.forename: Kei
authors.initials: K
authors.lastname: Iwata
authors.forename: Erika
authors.initials: E
authors.lastname: Naito
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Yamashita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kakino
authors.forename: Satoshi
authors.initials: S
authors.lastname: Taharaguchi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kimachi
authors.forename: Motonobu
authors.initials: M
authors.lastname: Hara
authors.forename: Kozo
authors.initials: K
authors.lastname: Takase
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D011558:Herpesvirus 1, Suid / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology; D031787:Sasa; D014709:Vero Cells
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides