title: Focal macular photopic negative response in patients with optic neuritis.
abstract: OBJECTIVE
  To investigate, by focal macular electroretinography (ERG), the change of photopic negative response (PhNR) in the recovery of visual function in patients with optic neuritis.
  
  
  METHODS
  Focal macular ERG was recorded from nine patients with acute optic neuritis (38.6 ± 10.2 years). The photostimulator device projected 15° visual angle spotlight onto the macula. Focal macular ERG recording was performed at the onset and at 1 month and 6 months after the onset of optic neuritis. The results were compared between each recording for seven of the patients.
  
  
  RESULTS
  All patients decreased in the vision below 20/100 and had central scotoma. Vision improved more than 20/20 within 1 month and full-visual field recovered within 6 months after the onset in all patients. The amplitude of the a-wave, b-wave, and PhNR of focal macular ERG at the onset was significantly attenuated in eyes with optic neuritis (66.8 ± 15.5, 65.8 ± 17.7, and 65.2 ± 14.4% of normal control, respectively). The amplitude of the a-wave and b-wave increased gradually after steroid pulse therapy. The increase in a-wave amplitude was significant at 6 months (P = 0.046), whereas the PhNR amplitude did not show any significant change over 6 months after the onset of optic neuritis.
  
  
  CONCLUSIONS
  Our results suggest that inflammation at the onset of optic neuritis leads to functional deficits that extend to at least the inner nuclear layers of the retina, and that all but the ganglion cell layers of retina recover.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. nakamrha@tenriyorozu-hp.or.jp
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Yokota
authors.forename: K
authors.initials: K
authors.lastname: Ogino
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D004596:Electroretinography / Q000379:methods*; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D014792:Visual Acuity; D014794:Visual Fields