title: Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction.
abstract: We synthesised aryl acetylene derivatives as versatile probes for labelling of oligonucleotides. RNA oligomers bearing an aryl acetylene molecule rapidly reacted with benzylazide derivatives under ligand-free click reaction conditions.
authors.affiliation: United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ueno
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kitade
mesh_terms: D000114:Acetylene / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D008024:Ligands; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D049268:Positron-Emission Tomography; D012313:RNA / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D008024:Ligands; D009841:Oligonucleotides; D012313:RNA; D003300:Copper; D000114:Acetylene