title: Impairment in processing visual information at the pre-attentive stage in patients with a major depressive disorder: a visual mismatch negativity study.
abstract: We compared the pre-attentive processing in patients with a major depressive disorder (MDD) and matched healthy controls as indexed by the visual mismatch negativity (vMMN) elicited by exposure duration of visual stimuli randomly presented on both peripheral visual fields. To obtain the memory-comparison-based visual MMN, the role of standard and deviant stimuli was reversed in separate blocks. Compared with healthy participants, MDD patients exhibited decreased MMN amplitudes of long duration deviant only and this deficit was not correlated with the depression severity. These data suggests functional impairment of pre-attentive basic visual information processing in MDD patients.
authors.affiliation: Department of Medical Psychology, Public Health Institute of Harbin Medical University, Heilongjiang Province, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Qiu
authors.forename: Xiuxian
authors.initials: X
authors.lastname: Yang
authors.forename: Zhengxue
authors.initials: Z
authors.lastname: Qiao
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Ning
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Lun
authors.initials: L
authors.lastname: Zhao
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010468:Perceptual Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D014473:Unconscious, Psychology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult