title: Unexpected synthesis of indolo[1,2-c]quinazolines by a sequential Ugi 4CC-Staudinger-aza-Wittig-nucleophilic addition reaction.
abstract: A new sequential Ugi-Staudinger-aza-Wittig-nucleophilic addition reaction was developed to construct indolo[1,2-c]quinazoline derivatives, starting from the easily accessible 2-azidobenzaldehyde, carboxylic acid, 2-acylaniline and isocyanide. It is noteworthy that this is the first report of the cyclization of the Ugi adduct to give a dihydroindole ring system with two quaternary carbon centers, via the nucleophilic addition reaction of the methine group to the carbonyl group.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, 430079, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.forename: Yi-Bo
authors.initials: YB
authors.lastname: Nie
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Ming-Wu
authors.initials: MW
authors.lastname: Ding
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis*
chemical_list: D001372:Aza Compounds; D001386:Azides; D007211:Indoles; D011799:Quinazolines