title: The influence of assisted reproductive technology on women with pregnancy-induced hypertension: a retrospective study at a Japanese Regional Perinatal Center.
abstract: OBJECTIVE
  To evaluate clinical features of assisted reproductive technology (ART) patients with pregnancy-induced hypertension (PIH) compared to spontaneously conceived PIH patients.
  
  
  METHODS
  We retrospectively compared PIH incidence, maternal outcomes, and neonatal outcomes among these patients.
  
  
  RESULTS
  Preeclampsia, cesarean rate, and massive maternal bleeding were significantly more common in the ART group. Neonatal outcomes showed no significant difference between the groups. Multiple regression analysis revealed ART as an independent risk factor for preeclampsia. However, higher cesarean rate and massive bleeding were mainly associated with multiple pregnancy.
  
  
  CONCLUSIONS
  ART patients with PIH had an increased incidence of preeclampsia, cesarean delivery, and massive maternal hemorrhage.
authors.affiliation: Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. hidehiko@pluto.dti.ne.jp
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Miyake
authors.forename: Nao
authors.initials: N
authors.lastname: Iwasaki
authors.forename: Akihito
authors.initials: A
authors.lastname: Nakai
authors.forename: Shunji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takeshita
mesh_terms: D000328:Adult; D002585:Cesarean Section; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D016015:Logistic Models; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D012189:Retrospective Studies