title: Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: a 6-month double-blind controlled trial.
abstract: Results from a pilot project indicate that isoflavones and exercise could have an additive effect on body composition and clinical risk factors of CVD in postmenopausal women. The objective of the present study was to assess the combined effect of exercise and isoflavones in overweight-to-obese postmenopausal women. In this double-blind randomised controlled trial, 100 overweight-to-obese (BMI 29·9 (sd 3·2) kg/m2) postmenopausal women were assigned to four groups: (1) placebo (PLA); (2) isoflavones (ISO); (3) exercise and placebo (Ex+PLA); (4) exercise and isoflavones (Ex+ISO). The supplementation contained 70 mg/d of isoflavones. Exercise consisted of three weekly sessions of resistance training and aerobics. Outcome measures included fat mass (FM), lean body mass (LBM), bone mineral density, lipid profile, fasting glucose, fasting insulin and insulin resistance (homeostasis assessment model). The main effects of exercise were observed for total FM (P = 0·02), FM% (P < 0·01), trunk FM% (P = 0·05), arm FM% (P < 0·01), leg FM% (P = 0·02), arm LBM (P < 0·01), leg LBM (P = 0·02) and C-reactive protein (P < 0·01). A main effect was detected for isoflavones in improving leg FM% (P = 0·05). No interactions were observed between isoflavones and exercise. In conclusion, it was observed that 6 months of exercise brought favourable changes in total FM, FM% and LBM in overweight postmenopausal women. No synergistic effects were observed between exercise and isoflavones. However, isoflavones could have a beneficial effect on leg FM%.
authors.affiliation: Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, QC, Canada J1K 2R1.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Choquette
authors.forename: Éléonor
authors.initials: É
authors.lastname: Riesco
authors.forename: Éric
authors.initials: É
authors.lastname: Cormier
authors.forename: Tommy
authors.initials: T
authors.lastname: Dion
authors.forename: Mylène
authors.initials: M
authors.lastname: Aubertin-Leheudre
authors.forename: Isabelle J
authors.initials: IJ
authors.lastname: Dionne
mesh_terms: D050154:Adiposity; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D049628:Body Size; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D019587:Dietary Supplements; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000627:therapeutic use*; D007866:Leg; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000628:therapy; D050177:Overweight / Q000097:blood / Q000178:diet therapy / Q000628:therapy*; D017698:Postmenopause; D055070:Resistance Training; D012307:Risk Factors; D013025:Glycine max / Q000737:chemistry*
chemical_list: D007529:Isoflavones; D002097:C-Reactive Protein