title: [Relationship between genetic polymorphism of metabolizing enzymes and lung cancer susceptibility].
abstract: BACKGROUND
  To investigate the relations between metabolizing enzymes' genetic polymorphism and lung cancer risk in Chinese, especially in heavy smokers.
  
  
  METHODS
  CYP1A1, 2D6, 2E1 and GSTM1 genotypes were detected in 180 patients with lung cancer and 224 controls by PCR-based genotype assays.
  
  
  RESULTS
  CYP1A1 variant allele, CYP2D6 wild allele, CYP2E1 A genotype, GSTM1-null genotype were found to be associated with lung cancer. The individuals who carried GSTM1-null genotype and one of the CYP1A1, CYP2D6, CYP2E1 'in risk' genotypes had a 2.24-2.69 fold increased risk of lung cancer. The heavy smokers had a significantly increased risk of lung cancer than the non-smokers who carried the same genotype of metabolizing enzymes. The heavy smoker who carried all the four 'in risk' genotypes of metabolizing enzymes had an obviously increased risk of lung cancer (OR=9.85, 95%CI=2.30-45.71).
  
  
  CONCLUSIONS
  The individuals who carry the 'in risk' genotype of metabolizing enzymes have an increased risk of lung cancer. It is positively associated with tobacco carcinogen dose.
authors.affiliation: Department of Medical Oncology, Beijing Tuberculosis and Thoracic Tumor Hospital, Beijing 101149, P.R.China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Gu
authors.forename: Shucai
authors.initials: S
authors.lastname: Zhang
authors.forename: Baitang
authors.initials: B
authors.lastname: Lai
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xiuping
authors.initials: X
authors.lastname: Zhan