title: Monosodium glutamate neonatal intoxication associated with obesity in adult stage is characterized by chronic inflammation and increased mRNA expression of peroxisome proliferator-activated receptors in mice.
abstract: The monosodium glutamate (MSG) neonatal administration in mice provides a model of obesity with impaired glucose tolerance (IGT) and insulin resistance. However, the inflammatory profile of cytokines produced from fat tissue and its relationship to the metabolic dysfunction induced by MSG have not yet been revealed. The aim of this study was to establish the inflammatory profile attributed to MSG by measuring the expression of adipokines in visceral fat and serum of 19-week-old mice as well as the peroxisome proliferator-activated receptors alpha and gamma (PPARα and γ). Some metabolic and biochemical parameters were also quantified. The MSG increased mRNA expression of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNFα), resistin and leptin, but adiponectin did not exhibit any changes. In addition, impaired glucose tolerance, increased levels of insulin, resistin and leptin were observed in serum. Both PPARα and PPARγ were activated in MSG-induced obese mice, which might explain its inflammatory profile. However, liver transaminases were severely depressed, indicating that MSG may also induce liver injury, contributing to inflammation. The MSG neonatal neuro-intoxication in mice may thus provide a model of obesity and inflammation characterized by the dual activation of PPARα and PPARγ, which might offer new insights into the mechanism of inflammatory diabetes in obesity leading to steatohepatitis, as well as a suitable model to study the role of new therapeutic agents to prevent or reduce insulin resistance, the inflammatory state and liver steatosis.
authors.affiliation: Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University of Iztapalapa, DF, Mexico.
authors.forename: Ruben
authors.initials: R
authors.lastname: Roman-Ramos
authors.forename: Julio C
authors.initials: JC
authors.lastname: Almanza-Perez
authors.forename: Rebeca
authors.initials: R
authors.lastname: Garcia-Macedo
authors.forename: Gerardo
authors.initials: G
authors.lastname: Blancas-Flores
authors.forename: Angeles
authors.initials: A
authors.lastname: Fortis-Barrera
authors.forename: Edgar I
authors.initials: EI
authors.lastname: Jasso
authors.forename: Mario
authors.initials: M
authors.lastname: Garcia-Lorenzana
authors.forename: Alfonso E
authors.initials: AE
authors.lastname: Campos-Sepulveda
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Alarcon-Aguilar
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000503:physiopathology; D000375:Aging / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000150:complications; D005260:Female; D005503:Food Additives / Q000378:metabolism / Q000633:toxicity*; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012970:Sodium Glutamate / Q000378:metabolism / Q000633:toxicity*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D005503:Food Additives; D007328:Insulin; D047492:Peroxisome Proliferator-Activated Receptors; D012333:RNA, Messenger; D012970:Sodium Glutamate