title: Initial biopsy outcome prediction in Korean patients-comparison of a noble web-based Korean prostate cancer risk calculator versus prostate-specific antigen testing.
abstract: We developed and validated a novel Korean prostate cancer risk calculator (KPCRC) for predicting the probability of a positive initial prostate biopsy in a Korean population. Data were collected from 602 Koreans who underwent initial prostate biopsies due to an increased level of prostate-specific antigen (PSA), a palpable nodule upon digital rectal examination (DRE), or a hypoechoic lesion upon transrectal ultrasound (TRUS). The clinical and laboratory variables were analyzed by simple and multiple logistic regression analysis. The area under the receiver operating characteristic curve (AUC) was computed to compare its performance to PSA testing alone. Prostate cancer was detected in 172 (28.6%) men. Independent predictors included age, DRE findings, PSA level, and prostate transitional zone volume. We developed the KPCRC using these variables. The AUC for the selected model was 0.91, and that of PSA testing alone was 0.83 (P < 0.001). The AUC for the selected model with an additional dataset was 0.79, and that of PSA testing alone was 0.73 (P = 0.004). The calculator is available on the website: http://pcrc.korea.ac.kr. The KPCRC improved the performance of PSA testing alone in predicting the risk of prostate cancer in a Korean population. This calculator would be a practical tool for physicians and patients.
authors.affiliation: Department of Urology, Korea University College of Medicine, Seoul, Korea. jaeyoungpark@korea.ac.kr
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Park
authors.forename: Sungroh
authors.initials: S
authors.lastname: Yoon
authors.forename: Man Sik
authors.initials: MS
authors.lastname: Park
authors.forename: Dae-Yeon
authors.initials: DY
authors.lastname: Cho
authors.forename: Hong-Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Du Geon
authors.initials: du G
authors.lastname: Moon
authors.forename: Duck Ki
authors.initials: DK
authors.lastname: Yoon
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001707:Biopsy, Needle; D051517:Digital Rectal Examination; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012372:ROC Curve; D056910:Republic of Korea; D012306:Risk; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen