title: [Anti-atherosclerotic effect of fibrates and eicosapentaenoic acid].
abstract: Fibrates and eicosapentaenoic acid (EPA) are effective in lowering elevated plasma triglycerides(TG) and low density lipoprotein cholesterol(LDL-C). These drugs have shown to reduce the risk of major cardiovascular events by several studies. Fibrates activate peroxisome proliferator-activated receptors(PPAR), especially PPARa. EPA and its metabolites act in the body by their interactions with the metabolites of arachidonic acid. Fibrates and EPA have nonlipid peliotropic effects such as anti-inflammation, endothelial-dependent smooth muscle relaxation and anti-thrombus in vascular wall. Thus it is suggested that peliotropic effects of these drugs contribute to the reduction of atherosclerosis progression.
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
mesh_terms: D000893:Anti-Inflammatory Agents; D016718:Arachidonic Acid / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D018450:Disease Progression; D015118:Eicosapentaenoic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D058607:Fibric Acids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular; D047493:PPAR alpha / Q000378:metabolism; D012306:Risk; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D014280:Triglycerides / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D058607:Fibric Acids; D008077:Lipoproteins, LDL; D047493:PPAR alpha; D014280:Triglycerides; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid