title: [A case of AGC with pCR after preoperative chemotherapy including S-1 plus cisplatin].
abstract: A 79-year-old man complaining of epigastralgia was examined and diagnosed with advanced gastric cancer (UML, Type 5, Ant-Less-Gre, cT4a, cN1, cH0, cP1, cStage IV). A poor prognosis was predicted, but we tried preoperative chemotherapy hoping for a down-staging of the tumor. We chose a regimen of S-1 plus cisplatin as follows: S-1 (60 mg/m2) was administered orally for 3 weeks followed 2 weeks of rest, and cisplatin (50 mg/m2) was administered by intravenous drip on day 8. After three cycles of treatment, diagnostic laparoscopic examination revealed a suspected serosal invasion of the main tumor, but peritoneal dissemination was not seen, and abdominal washing cytology was negative. After the fourth cycle of treatment, total gastrectomy with lymph node dissection (D1+No. 7, 8a, 9, R0) was performed. Histological examination of the resected specimens revealed no residual cancer cells in the primary lesion or regional lymph nodes, resulting in a diagnosis of complete response to chemotherapy according to the Japanese Classification of Gastric Carcinoma. The postoperative course was uneventful, and he has been fine as an outpatient.
authors.affiliation: Dept. of Surgical Oncology, Kanazawa Medical University.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funaki
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Yukako
authors.initials: Y
authors.lastname: Ohno
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Tomita
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hosokawa
authors.forename: Miki
authors.initials: M
authors.lastname: Yokoi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yoshitani
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kinami
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Omote
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Ueda
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nakano
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000628:therapy*; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin