title: [Roles of lipid mediators in controlling vascular inflammation and the progression of atherosclerosis].
abstract: Atherosclerosis is recognized as an inflammatory condition of the vessel wall, characterized by accumulation of inflammatory cells such as macrophages and T cells. There are accumulating evidences that chemokines, cytokines, and lipid mediators coordinately modulate platelet- or leukocyte-endothelial cell interactions, and contribute to the maintenance of vascular homeostasis. This review focuses on the role of lipid mediators, especially those derived from polyunsaturated fatty acids, in controlling vascular inflammation and the progression of atherosclerosis.
authors.affiliation: Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo.
authors.forename: Jin
authors.initials: J
authors.lastname: Endo
authors.forename: Makoto
authors.initials: M
authors.lastname: Arita
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D002450:Cell Communication; D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D018450:Disease Progression; D042783:Endothelial Cells / Q000166:cytology / Q000473:pathology; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000627:therapeutic use; D005231:Fatty Acids, Unsaturated; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D018836:Inflammation Mediators / Q000502:physiology*; D015289:Leukotrienes / Q000502:physiology; D008084:Lipoxygenase / Q000502:physiology*; D008264:Macrophages; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology*; D011453:Prostaglandins / Q000502:physiology*; D013601:T-Lymphocytes
chemical_list: D018925:Chemokines; D016207:Cytokines; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D018836:Inflammation Mediators; D015289:Leukotrienes; D011453:Prostaglandins; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases