title: Imaging characteristics of abdominal tumor in association with paraneoplastic pemphigus.
abstract: The purpose of this study was to report the imaging manifestations of tumor associated with PNP. Imaging features of abdominal tumor associated with PNP in 6 cases were retrospectively analyzed. Patients were given PET/CT (n = 1) or multidetector CT (n = 5) examination. Six cases of PNP were associated with hyaline-vascular type Castleman's disease. Calcification was revealed in 2 cases. One case showed heterogeneous FDG uptake on PET. Among the 5 cases receiving a dynamic enhanced CT scan, inhomogeneous marked enhancement (n = 3) or moderate enhancement (n = 2) with hypo-attenuation areas of patchy shape were presented in the arterial phase. Three cases showed persistent enhancement in equilibrium and delayed phases, and intratumoral hypo-attenuation areas which pathologically proved to be an abundance of fibrotic components which gradually disappeared. PNP is a relatively rare special type of pemphigus, with distinctive clinical and pathological manifestations. Imaging examination plays important role in the detection and qualitative diagnosis of abdominal tumors associated with PNP.
authors.affiliation: Department of Radiology, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. liu.qingyu@163.com
authors.forename: Qing-yu
authors.initials: QY
authors.lastname: Liu
authors.forename: Ming-chun
authors.initials: MC
authors.lastname: Chen
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Chen
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.forename: Hui-jun
authors.initials: HJ
authors.lastname: Hu
authors.forename: Hai-gang
authors.initials: HG
authors.lastname: Li
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D005871:Castleman Disease / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000453:epidemiology*; D010392:Pemphigus / Q000453:epidemiology*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D055815:Young Adult