title: [Study on diagnostic accuracy of ultrasound-guided core needle breast biopsy].
abstract: OBJECTIVE
  to evaluate the diagnostic accuracy of ultrasound-guided core needle biopsy of breast tumors.
  
  
  METHODS
  six hundred and sixty-seven cases of core needle biopsy of breast encountered during the period from January, 2004 to June, 2007 were retrieved from the archival file and retrospectively reviewed. The core needle biopsy diagnoses were correlated with the histologic findings of the subsequent surgical excision specimens. The discrepancies were further analyzed.
  
  
  RESULTS
  three hundred and eighty-two patients had core needle biopsy diagnosis followed by local excision, breast conservation surgery or mastectomy. Two hundred and eighty-one cases were confirmed to have malignancy in the surgical specimens. Review of the corresponding core needle biopsies showed 4 false-negative cases, no false-positive cases, 28 cases with underestimation and 2 cases with overestimation. The false-negative rate was 1.4% (4/281). The rate of underestimation for ductal carcinoma-in-situ was 6/11. The diagnostic accuracy of core needle biopsy was 94.7% (266/281).
  
  
  CONCLUSIONS
  in order to improve the diagnostic accuracy of core needle biopsy of breast tumors, recognition of the limitation of the procedure, application of immunohistochemistry and awareness of potentially rare entities are important.
authors.affiliation: Department of Pathology, General Hospital of People's Liberation Army, Beijing 100853, China. liuwanheng@yahoo.com.cn
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Xi-Ru
authors.initials: XR
authors.lastname: Li
authors.forename: Jun-Lai
authors.initials: JL
authors.lastname: Li
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Wang
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Yi-Qiong
authors.initials: YQ
authors.lastname: Zheng
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wei
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D001707:Biopsy, Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D019002:CD56 Antigen / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D053555:Keratin-5 / Q000378:metabolism; D008408:Mastectomy / Q000379:methods; D008565:Membrane Proteins / Q000378:metabolism; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional / Q000379:methods; D016217:Ultrasonography, Mammary
chemical_list: D019002:CD56 Antigen; C081876:CKAP4 protein, human; D053555:Keratin-5; D008565:Membrane Proteins