title: Plasma levels of lignocaine during tumescent local anaesthesia in children with burns.
abstract: The aim of the study was to assess the changes in plasma lignocaine concentrations over time when the tumescent solution is injected into subcutaneous tissue of children undergoing surgical treatment of burns. Sixteen consecutive children with burns were studied using a prospective study design. After induction of general anesthesia, tumescent lignocaine solution 0.1% with adrenaline in nine patients (adrenaline group) for the treatment of postburn sequelae, or without adrenaline in seven patients (no-adrenaline group) for the treatment of acute burns, was injected into the subcutaneous tissue of burned and donor areas. The maximum dose of lignocaine was 7 mg/kg. Blood samples were collected before the start of the injection as well as at 5, 10, 20, 30, 45, 60, 90 minutes and 2, 4, 8, 12, 24 hours after the infiltration was completed. The course of lignocaine plasma levels was chaotic in the adrenaline group and biphasic during the first hour in the no-adrenaline group. The maximum plasma concentration of lignocaine was 2.09 microg/ml in the adrenaline group and 1.98 microg/ml in the no-adrenaline group. No adverse reactions were noted. Tumescent injection in burned children resulted in lignocaine plasma concentrations that were always lower than the often quoted value of 5 microg/ml, considered to be the toxic plasma threshold in adults. These data lend support to the use of lignocaine using the tumescent technique in burned paediatric patients.
authors.affiliation: Department of Anesthesia and Intensive Care, Meyer Children Hospital, Florence, Italy. l.bussolin@meyer.it
authors.forename: L
authors.initials: L
authors.lastname: Bussolin
authors.forename: P
authors.initials: P
authors.lastname: Serio
authors.forename: P
authors.initials: P
authors.lastname: Busoni
authors.forename: R
authors.initials: R
authors.lastname: Schiatti
authors.forename: M
authors.initials: M
authors.lastname: Salvadori
mesh_terms: D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000097:blood*; D002056:Burns / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008012:Lidocaine / Q000097:blood*; D008297:Male; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine