title: Rare HLA alleles and their predicted haplotypes in Tzu Chi Taiwanese marrow donor registry.
abstract: The marrow donor registry of Buddhist Tzu Chi Stem Cells Centre (BTCSCC) maintained an HLA database of 291677 bone marrow volunteer donors from 1993 to 2008. From the 291677 donors we identified 28 rare alleles and discovered six novel alleles in Taiwanese. Our criterion of a rare allele was according to the definition, set by the National Marrow Donor Program (NMDP), one having a frequency of 0.002% (1/50,000) or less. The authenticity of the rare alleles was confirmed by sequence specific primer (SSP) typing protocol and/or sequence-based typing (SBT) method. This study reports the number of times the alleles were observed between 1993 and 2008, and the ethnicity of the donors carrying the rare or novel alleles.
authors.affiliation: Laboratory of Immunogenetics, Cord Blood Bank and Marrow Donor Registry, Buddhist Tzu Chi Medical Centre, Buddhist Compassion Relief Tzu Chi Foundation, Hualien, Taiwan. edward@tzuchi.com.tw
authors.forename: K L
authors.initials: KL
authors.lastname: Yang
authors.forename: M J
authors.initials: MJ
authors.lastname: Chen
authors.forename: M H
authors.initials: MH
authors.lastname: Shyr
authors.forename: C L
authors.initials: CL
authors.lastname: Lin
authors.forename: P Y
authors.initials: PY
authors.lastname: Lin
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D012042:Registries; D012189:Retrospective Studies; D013624:Taiwan; D014019:Tissue Donors
chemical_list: D006680:HLA Antigens