title: Advanced glycation end-products in myocardium-supported vessels: effects of heart failure and diabetes mellitus.
abstract: BACKGROUND
  Disturbed glucose metabolism, particularly in diabetes, is an important but not the sole factor leading to advanced glycation end-product (AGE) formation. The AGE amount and its distribution in cardiopathic myocardial tissues in the presence or absence of diabetes are not well documented. The aim of this study was to assess AGE deposition in unaffected myocardial vessels in heart failure patients with and without diabetes mellitus type 2 (DM2) undergoing transplantation.
  
  
  METHODS
  The following groups were established: 14 hearts harvested from subjects with ischemic cardiopathy and DM2; 8 hearts from subjects with dilated cardiopathy with DM2; 67 hearts from subjects with ischemic cardiopathy; 47 hearts from subjects with dilated cardiopathy; and 14 hearts from autopsy cases with diagnosed DM2. A control group consisted of 20 heart donors. AGE localization was determined immunohistochemically in tissue sections. A semi-quantitative scale was used to assess reaction intensity in arteries, arterioles, capillaries, venules and veins.
  
  
  RESULTS
  Both types of cardiomyopathy increased AGE accumulation in intramyocardial veins more than in arteries. The presence of DM2 significantly increased AGE in arterioles and capillaries, especially when coexisting with cardiomyopathy. The type of cardiopathy did not influence the pattern of AGE accumulation in myocardial vessels.
  
  
  CONCLUSIONS
  Both chronic heart failure and DM2 intensified AGE pathology and changed the susceptibility of myocardial vasculature to glycation. However, chronic heart failure increases AGE deposition mostly in veins, whereas DM2 predisposes arterioles to AGE accumulation.
authors.affiliation: Silesian Center for Heart Diseases, Zabrze, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Nożyński
authors.forename: Michał
authors.initials: M
authors.lastname: Zakliczyński
authors.forename: Dominika
authors.initials: D
authors.lastname: Konecka-Mrówka
authors.forename: Roman
authors.initials: R
authors.lastname: Przybylski
authors.forename: Marian
authors.initials: M
authors.lastname: Zembala
authors.forename: Teresa
authors.initials: T
authors.lastname: Zielińska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mrówka
authors.forename: Dariusz
authors.initials: D
authors.lastname: Lange
authors.forename: Ewa
authors.initials: E
authors.lastname: Zembala-Nożyńska
authors.forename: Barbara
authors.initials: B
authors.lastname: Nikiel
authors.forename: Joanna
authors.initials: J
authors.lastname: Młynarczyk-Liszka
mesh_terms: D000328:Adult; D001344:Autopsy; D002196:Capillaries / Q000378:metabolism; D016022:Case-Control Studies; D002908:Chronic Disease; D003331:Coronary Vessels / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism*; D005260:Female; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006333:Heart Failure / Q000150:complications* / Q000378:metabolism* / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D014680:Veins / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced