title: Reprogramming of somatic cells to pluripotency.
abstract: Reprogramming of somatic cells into pluripotent stem cells has been achieved by introducing four transcription factors, Sox2, Oct3/4, Klf4 and c-Myc, in 2006. These induced pluripotent stem (iPS) cells have raised hopes for a new era of regenerative medicine because they can avoid the ethical problems and innate immune rejection associated with embryonic stem cells. However, the underlying molecular mechanism of reprogramming still remains unclear. In this chapter, we look back at the history of reprogramming research ranging from amphibian to mammalian cells and discuss our recent understanding of the molecular mechanisms of reprogramming and the possibility of utilizing reprogrammed cells for regenerative medicine.
authors.affiliation: Center for iPS Research and Application Institute for Integrated Cell-Material Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan, nakagawa@cira.kyoto-u.ac.jp.
authors.forename: Masato
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamanaka
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D000090062:Kruppel-Like Factor 4; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D039904:Pluripotent Stem Cells; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors / Q000235:genetics
chemical_list: C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D050814:Octamer Transcription Factor-3; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors