title: [A case report of locally advanced rectal carcinoma effectively treated with preoperative chemoradiotherapy].
abstract: The patient was an 80-year-old woman who was diagnosed with locally advanced low rectal cancer. It was unresectable and we performed chemoradiotherapy combined with S-1 (S-1 80 mg/m2, RT 1.8 Gy × 25, total 45 Gy). An effective reduction of primary region resulted in curative resection (super low anterior resection, D3 lymph node dissection, covering ileostomy) with preserving the anal sphincter. Histopathologically, therapeutic efficacy was Grade 2. Preoperative chemoradiation has been a standard therapy in Western countries and would control local recurrence. This case indicated that CRT could improve a rate of curative resection in patients with locally advanced rectal carcinomas.
authors.affiliation: Dept. of Surgery, Kinki University Faculty of Medicine, Nara Hospital.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Kitani
authors.forename: Kaoru
authors.initials: K
authors.lastname: Okajima
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kimura
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Ikeda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Inoue
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Iwama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakayama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Masaru
authors.initials: M
authors.lastname: Murata
authors.forename: Masao
authors.initials: M
authors.lastname: Yukawa
authors.forename: Kazuki
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ota
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D010094:Oxonic Acid / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000628:therapy*; D012007:Rectum / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid