title: New bibenzyl glycosides from leaves of Camellia oleifera Abel. with cytotoxic activities.
abstract: Studies on the chemical constituents of leaves of Camellia oleifera Abel. led to the isolation of 3 new bibenzyl glycosides. Their structures have been elucidated as 1-(3',5'-dihydroxy)phenyl-2-(4″-O-β-D-glucopyranosyl)phenylethane (1), 1-(3',5'-dimethoxy)phenyl-2-(4″-O-β-D-glucopyranosyl)phenylethane (2) and 1-(3',5'-dimethoxy)phenyl-2-[4″-O-β-D-glucopyranosyl(6→1)-O-α-L-rhamnopyranosyl]phenylethane (3) through spectral studies including HR-ESI-MS, ((1))H NMR, ((13))C NMR and 2D NMR experiments. All the above 3 bibenzyl glycosides showed cytotoxic activities to Hela and hep2 cell lines.
authors.affiliation: College of Bioengineering, Dalian University, Dalian, China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Tang
authors.forename: Baomin
authors.initials: B
authors.lastname: Feng
authors.forename: Liying
authors.initials: L
authors.lastname: Shi
authors.forename: Huiguo
authors.initials: H
authors.lastname: Wang
authors.forename: Yongqi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001593:Benzyl Compounds / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D028244:Camellia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves
chemical_list: C560696:1-(3',5'-dihydroxy)phenyl-2-(4''-O-beta-D-glucopyranosyl)phenylethane; C560697:1-(3',5'-dimetoxy)phenyl-2-(4''-O-beta-D-glucopyranosyl(6-1)-O-alpha-L-rhamnopyranosyl)phenylethane; C560698:1-(3',5'-dimetoxy)phenyl-2-(4''-O-beta-D-glucopyranosyl)phenylethane; D000972:Antineoplastic Agents, Phytogenic; D001593:Benzyl Compounds; D006027:Glycosides; D010936:Plant Extracts