title: The influence of tibial component fixation techniques on resorption of supporting bone stock after total knee replacement.
abstract: Periprosthetic bone resorption after tibial prosthesis implantation remains a concern for long-term fixation performance. The fixation techniques may inherently aggravate the "stress-shielding" effect of the implant, leading to weakened bone foundation. In this study, two cemented tibial fixation cases (fully cemented and hybrid cementing with cement applied under the tibial tray leaving the stem uncemented) and three cementless cases relying on bony ingrowth (no, partial and fully ingrown) were modelled using the finite element method with a strain-adaptive remodelling theory incorporated to predict the change in the bone apparent density after prosthesis implantation. When the models were loaded with physiological knee joint loads, the predicted patterns of bone resorption correlated well with reported densitometry results. The modelling results showed that the firm anchorage fixation formed between the prosthesis and the bone for the fully cemented and fully ingrown cases greatly increased the amount of proximal bone resorption. Bone resorption in tibial fixations with a less secure anchorage (hybrid cementing, partial and no ingrowth) occurred at almost half the rate of the changes around the fixations with a firm anchorage. The results suggested that the hybrid cementing fixation or the cementless fixation with partial bony ingrowth (into the porous-coated prosthesis surface) is preferred for preserving proximal tibial bone stock, which should help to maintain post-operative fixation stability. Specifically, the hybrid cementing fixation induced the least amount of bone resorption.
authors.affiliation: Department of Mechanical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, United Kingdom.
authors.forename: Desmond Y R
authors.initials: DY
authors.lastname: Chong
authors.forename: Ulrich N
authors.initials: UN
authors.lastname: Hansen
authors.forename: Rene
authors.initials: R
authors.lastname: van der Venne
authors.forename: Nico
authors.initials: N
authors.lastname: Verdonschot
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Amis
mesh_terms: D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001843:Bone Cements; D001862:Bone Resorption; D001842:Bone and Bones / Q000473:pathology; D002484:Cementation; D003720:Densitometry / Q000379:methods; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D007717:Knee / Q000473:pathology; D007719:Knee Joint / Q000601:surgery; D007720:Knee Prosthesis; D016348:Osseointegration / Q000502:physiology; D020959:Polyethylene / Q000737:chemistry; D011474:Prosthesis Design; D013314:Stress, Mechanical; D013977:Tibia / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods; D053443:Visible Human Projects
chemical_list: D001843:Bone Cements; D020959:Polyethylene