title: Tandem Blaise-Nenitzescu reaction: one-pot synthesis of 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones from nitriles.
abstract: In contrast to the reaction of benzoquinones with β-enaminoesters providing indoles (Nenitzescu reaction), the tandem one-pot reaction of the Blaise reaction intermediate, zinc bromide complex of β-enaminoesters, with benzoquinone affords 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones in good to excellent yields (tandem Blaise-Nenitzescu reaction).
authors.affiliation: Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Yu Sung
authors.initials: YS
authors.lastname: Chun
authors.forename: Ka Yeon
authors.initials: KY
authors.lastname: Ryu
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyunik
authors.initials: H
authors.lastname: Shin
authors.forename: Sang-gi
authors.initials: SG
authors.lastname: Lee
mesh_terms: D000588:Amines / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis*; D006900:Hydroxylation; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
chemical_list: D000588:Amines; D001572:Benzofurans; D009570:Nitriles; C105430:benzofuran