title: Adaptation to short-term stress exposures prevents poststress dysfunction of calcium-activated potassium channels in coronary vessels.
abstract: Adaptation to short-term stress exposures prevents immobilization stress-induced decrease in functional activity of BK(Ca)channels in smooth muscle cells of coronary vessels developing against the background of NO overproduction and increase in the relative content of oxidized glutathione (change in redox state of the glutathione system). The protective antistress mechanisms of adaptation probably include prevention of NO overproduction by inducible NO synthase and maintenance of dependent glutathione redox state functional activity of BK(Ca)channels in smooth muscle cells of coronary vessels.
authors.affiliation: Vitebsk State Order of People's Friendship Medical University, Byelorussia. pronirvgmu@mail.ru
authors.forename: A P
authors.initials: AP
authors.lastname: Solodkov
authors.forename: S S
authors.initials: SS
authors.lastname: Maiorova
authors.forename: S S
authors.initials: SS
authors.lastname: Lazuko
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000502:physiology; D005260:Female; D007103:Immobilization / Q000502:physiology; D051036:Large-Conductance Calcium-Activated Potassium Channels / Q000037:antagonists & inhibitors / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology*; D019789:Tetraethylammonium / Q000494:pharmacology
chemical_list: D051036:Large-Conductance Calcium-Activated Potassium Channels; D019789:Tetraethylammonium