title: Magnetically driven agitation in a tube mixer affords clog-resistant fast mixing independent of linear velocity.
abstract: An economical and simple flow mixer based on magnetically driven agitation in a tube (MDAT) is reported. Mixing via MDAT compared favorably to both Tee and multilaminar mixers at low flow and was successfully used to screen and optimize two challenging organometallic reactions at low temperature without clogging or the need for high dilution.
authors.affiliation: Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA. sarah_dolman@merck.com
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Dolman
authors.forename: Jason L
authors.initials: JL
authors.lastname: Nyrop
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Kuethe
mesh_terms: D003198:Computer Simulation; D004867:Equipment Design / Q000295:instrumentation; D044085:Microfluidics / Q000295:instrumentation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature
chemical_list: D009942:Organometallic Compounds