title: Tumor necrosis factor receptor cross-talk.
abstract: Extensive research has been performed to unravel the mechanistic signaling pathways mediated by tumor necrosis factor receptor 1 (TNFR1), by contrast there is limited knowledge on cellular signaling upon activation of TNFR2. Recently published data have revealed that these two receptors not only function independently, but also can influence each other via cross-talk between the different signaling pathways initiated by TNFR1 and TNFR2 stimulation. Furthermore, the complexity of this cross-talk is also dependent on the different signaling kinetics between TNFR1 and TNFR2, by which a delicate balance between cell survival and apoptosis can be maintained. Some known signaling factors and the kinetics that are involved in the receptor cross-talk between TNFR1 and TNFR2 are the topic of this review.
authors.affiliation: Department of Molecular Neurobiology, University of Groningen, The Netherlands.
authors.forename: Petrus J W
authors.initials: PJ
authors.lastname: Naudé
authors.forename: Johan A
authors.initials: JA
authors.lastname: den Boer
authors.forename: Paul G M
authors.initials: PG
authors.lastname: Luiten
authors.forename: Ulrich L M
authors.initials: UL
authors.lastname: Eisel
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D020239:Receptor Cross-Talk / Q000502:physiology*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000502:physiology*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D047990:TNF Receptor-Associated Factor 1 / Q000502:physiology; D047992:TNF Receptor-Associated Factor 2 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D016328:NF-kappa B; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D047990:TNF Receptor-Associated Factor 1; D047992:TNF Receptor-Associated Factor 2; D014409:Tumor Necrosis Factor-alpha