title: Differential uptake of 18F-FDG in patients with synchronous lung cancers.
abstract: (18)F-fluoro-2-deoxy-D: -glucose positron emission tomography ((18)F-FDG PET/CT) has developed into the standard of care for investigating patients with non-small cell lung cancer (NSCLC) to determine the optimal treatment. However, although the majority of patients with NSCLC do have intense uptake of tracer, false negatives do occur and should be considered. We report cases of patients that have synchronous NSCLCs. In both cases, there was intense uptake of FDG in one tumour type, with very low grade uptake in the separate tumour. Histology confirmed separate lung malignancies, demonstrating that differential FDG uptake may not always be inflammatory and should be considered to have a separate malignant aetiology.
authors.affiliation: PET/CT Centre, St. Thomas Hospital NHS Trust, London, UK. s.navalkissoor@nhs.net
authors.forename: Shaunak
authors.initials: S
authors.lastname: Navalkissoor
authors.forename: Teresa
authors.initials: T
authors.lastname: Szyszko
authors.forename: Sheila
authors.initials: S
authors.lastname: Rankin
authors.forename: Gopinath
authors.initials: G
authors.lastname: Gnanasegaran
mesh_terms: D000368:Aged; D001692:Biological Transport; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18