title: Myeloproliferative disorders with t(8;9)(p12;q33): a case report and review of the literature.
abstract: The 8p11 myeloproliferative syndrome (EMS) is an aggressive neoplasm associated with chromosomal translocations involving the fibroblast growth factor receptor 1 tyrosine kinase gene on chromosome 8p11-12. The most frequent partner genes are in decreasing order of frequency: ZNF198 (or ZMYM2, zinc finger MYM type 2), CEP110 (centrosomal protein 110 kDa), FOP (or FGFR1OP, FGFR1 [fibroblast growth factor receptor 1] oncogene partner), and BCR (breakpoint cluster region) located on 13q12, 9q33, 6q27, and 22q11, respectively. Here the authors report a new case of translocation (8;9)(p12;q33) without lymphoma prior to the progression into acute leukemia. Currently, only patients underwent bone marrow transplantation stand a chance of long-term survival. In the future, FGFR1 inhibitor might be the specific and effective therapeutic target for EMS.
authors.affiliation: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou City, China. shaoyanhu67@126.com
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Hu
authors.forename: Yaxiang
authors.initials: Y
authors.lastname: He
authors.forename: Xueming
authors.initials: X
authors.lastname: Zhu
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Hailong
authors.initials: H
authors.lastname: He
mesh_terms: D000208:Acute Disease; D002648:Child; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*