title: B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.
abstract: Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. Thus, depletion of B cells in old mice was followed by expansion of multipotent primitive progenitors and common lymphoid progenitors, a revival of B-lymphopoiesis in the bone marrow, and generation of a rejuvenated peripheral compartment that enhanced the animal's immune responsiveness to antigenic stimulation. Collectively, our results suggest that immunosenescence in the B-lineage is not irreversible and that depletion of the long-lived B cells in old mice rejuvenates the B-lineage and enhances immune competence.
authors.affiliation: Department of Immunology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Keren
authors.forename: Shulamit
authors.initials: S
authors.lastname: Naor
authors.forename: Shahar
authors.initials: S
authors.lastname: Nussbaum
authors.forename: Karin
authors.initials: K
authors.lastname: Golan
authors.forename: Tomer
authors.initials: T
authors.lastname: Itkin
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Marc
authors.initials: M
authors.lastname: Schmidt-Supprian
authors.forename: Tsvee
authors.initials: T
authors.lastname: Lapidot
authors.forename: Doron
authors.initials: D
authors.lastname: Melamed
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D018951:Antigens, CD20 / Q000378:metabolism; D053265:B-Cell Activation Factor Receptor / Q000378:metabolism; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D006801:Humans; D007109:Immunity; D008212:Lymphocyte Depletion; D038041:Lymphopoiesis / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D012060:Rejuvenation; D013234:Stem Cells / Q000166:cytology / Q000276:immunology
chemical_list: D018951:Antigens, CD20; D053265:B-Cell Activation Factor Receptor