title: Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome.
abstract: OBJECTIVE
  To correlate visual field sensitivity (VFS) loss on standard automated perimetry (SAP) and quadrantic macular thickness on optical coherence tomography (OCT) in patients with permanent temporal hemianopia from chiasmal compression.
  
  
  METHODS
  Forty eyes from 40 patients with chiasmal compression and 40 healthy eyes were submitted to standard automated perimetry and Stratus-OCT scanning. Raw data of the fast macular thickness scanning protocol were exported and macular thickness measurements were recorded and averaged for each quadrant and half of the central area. The correlation between visual field sensitivity loss and optical coherence tomography measurements was tested with Pearson's correlation coefficients and with linear regression analysis.
  
  
  RESULTS
  A significant association was found between each macular thickness parameter and the corresponding central VF mean sensitivity. The strongest association was observed between superonasal macular thickness and the inferotemporal mean defect measured both in decibel (R=0.47; p=0.001) and in 1/Lambert (R=0.59; p<0.0001) units.
  
  
  CONCLUSIONS
  Stratus-OCT-measured macular thickness was topographically related with visual field sensitivity loss in patients with temporal hemianopia from chiasmal compression. Such measurements could prove clinically useful in the diagnosis and follow-up of patients with chiasmal compression. ClinicalTrial.gov identifier number: NCT0039122.
authors.affiliation: Hospital das Clínicas, Universidade de São Paulo, SP, Brazil. fredcastelo@terra.com.br
authors.forename: Frederico Castelo
authors.initials: FC
authors.lastname: Moura
authors.forename: Luciana Virginia Ferreira
authors.initials: LV
authors.lastname: Costa-Cunha
authors.forename: Roberto Freire Santiago
authors.initials: RF
authors.lastname: Malta
authors.forename: Mário Luiz Ribeiro
authors.initials: ML
authors.lastname: Monteiro
mesh_terms: D000328:Adult; D004812:Epidemiologic Methods; D005260:Female; D006423:Hemianopsia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009408:Nerve Compression Syndromes / Q000150:complications*; D009897:Optic Chiasm / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014794:Visual Fields / Q000502:physiology*