title: Time to revise the paradigm of hantavirus syndromes? Hantavirus pulmonary syndrome caused by European hantavirus.
abstract: Hantaviruses have previously been recognised to cause two separate syndromes: hemorrhagic fever with renal syndrome in Eurasia, and hantavirus pulmonary syndrome (HPS) in the Americas. However, increasing evidence suggests that this dichotomy is no longer fruitful when recognising human hantavirus disease and understanding the pathogenesis. Herein are presented three cases of severe European Puumala hantavirus infection that meet the HPS case definition. The clinical and pathological findings were similar to those found in American hantavirus patients. Consequently, hantavirus infection should be considered as a cause of acute respiratory distress in all endemic areas worldwide.
authors.affiliation: Infectious Diseases, Department of Clinical Microbiology, Umeå University, SE 901 85 Umeå, Sweden. johan.rasmuson@climi.umu.se
authors.forename: J
authors.initials: J
authors.lastname: Rasmuson
authors.forename: C
authors.initials: C
authors.lastname: Andersson
authors.forename: E
authors.initials: E
authors.lastname: Norrman
authors.forename: M
authors.initials: M
authors.lastname: Haney
authors.forename: M
authors.initials: M
authors.lastname: Evander
authors.forename: C
authors.initials: C
authors.lastname: Ahlm
mesh_terms: D000368:Aged; D005060:Europe; D005260:Female; D018804:Hantavirus Pulmonary Syndrome / Q000473:pathology* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D029262:Puumala virus / Q000302:isolation & purification*; D012128:Respiratory Distress Syndrome / Q000473:pathology*