title: Oral and maxillofacial surgeons' role in the first successful modified osteo-odonto-keratoprosthesis performed in the United States.
abstract: Corneal disease constitutes the second most common cause of blindness and often leads to corneal damage or scarring. Several corneal scarring is a complex and difficult condition for ophthalmologists to manage. In the most severe cases, the scarring is accompanied by excessive dryness and keratinization of the ocular surface. Certain etiologies, including Stevens-Johnson syndrome, cicatricial pemphigoid, Lyell's syndrome, and chemical trauma to the surface of the eye, are responsible for the most severe cases. Traditional allogeneic corneal transplantation is not effective because of the significant scarring and dryness of the eye. To allow light and images to be focused on the retina, a keratoprosthesis is required to position a lens on the surface of the eye. One of the oldest and most effective types of keratoprosthesis, the osteo-odonto-keratoprosthesis (OOKP), was first described and documented in 1963 by Strampelli and subsequently modified by Falcinelli et al. The modified OOKP (MOOKP) is a unique prosthesis consisting of a lens fabricated from a polymethylmethacrylate (PMMA) cylinder and cemented to an autogenous graft composed of tooth and bone, traditionally termed the osteo-odonto lamina. In this context, lamina refers to a thin rectangular plate of tooth and bone (Fig 1). The MOOKP involves 4 procedures performed in 3 surgical stages.
authors.affiliation: Department of Surgery, Division of Oral and Maxillofacial Surgery, University of Miami/Miller School of Medicine, Miami, FL 33176, USA. ysawatari@med.miami.edu
authors.forename: Yoh
authors.initials: Y
authors.lastname: Sawatari
authors.forename: Victor L
authors.initials: VL
authors.lastname: Perez
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Parel
authors.forename: Eduardo
authors.initials: E
authors.lastname: Alfonso
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Falcinelli
authors.forename: Johnny
authors.initials: J
authors.lastname: Falcinelli
authors.forename: Robert E
authors.initials: RE
authors.lastname: Marx
mesh_terms: D000539:Alveolar Process / Q000637:transplantation; D001766:Blindness / Q000209:etiology / Q000601:surgery*; D003315:Cornea / Q000601:surgery*; D003316:Corneal Diseases / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D019647:Oral Surgical Procedures / Q000379:methods*; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D013262:Stevens-Johnson Syndrome / Q000150:complications; D014070:Tooth / Q000637:transplantation