title: Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.
abstract: The influence of histone amino-terminal covalent modifications on gene regulation has drawn intense research efforts in recent years. It is now clear that activating and inactivating modifications have a key role in determining the gene-expression profile of an individual cell or cell lineage. Thus, differences in these modifications have a pivotal role in determining and maintaining cell fate during development. The interplay of histone methyltransferases (HMTs) and demethylases confers the plasticity necessary for changes in the gene-expression profile of a cell during differentiation or changes following environmental cues. The histone H3 lysine 27 (H3K27) demethylases Jmjd3 and UTX remove the gene-inactivating H3K27 dimethyl and trimethyl marks and are involved in inducing and/or maintaining gene expression. In this chapter, we highlight the role of the H3K27 demethylases Jmjd3 and UTX in gene expression.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. huebner@cshl.edu
authors.forename: M R
authors.initials: MR
authors.lastname: Hübner
authors.forename: D L
authors.initials: DL
authors.lastname: Spector
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D016922:Cellular Senescence / Q000235:genetics; D005786:Gene Expression Regulation; D015894:Genome, Human / Q000235:genetics; D056466:Histone Demethylases / Q000737:chemistry / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000737:chemistry / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D056466:Histone Demethylases; D056484:Jumonji Domain-Containing Histone Demethylases; C523998:KDM6A protein, human; C524220:KDM6B protein, human; D008239:Lysine