title: Is gastrointestinal dysfunction induced by gastric cancer peritoneal metastasis relevant to impairment of interstitial cells of Cajal?
abstract: Although impaired gastrointestinal motility from gastric cancer peritoneal metastasis (GCPM) causes extraordinary pain, its cause is unclear. Interstitial cells of Cajal (ICC) are apparently pacemaker cells, and their loss could cause motor dysfunction. In this study, we developed a mouse model for GCPM, and investigated electrophysiological changes in the small intestine and attendant changes in ICC. We found decreased ICC and disrupted electrical rhythm in the model. Pathologic ICC changes were well described. Cancer peritoneal metastasis may impair intestinal myoelectrical activity by damaging ICC and ICC networks. Interstitial cells of Cajal will be a target of palliative treatment and merit further study.
authors.affiliation: Department of Oncology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin, China.
authors.forename: Hongqun
authors.initials: H
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: Jinxue
authors.initials: J
authors.lastname: Tong
authors.forename: Lingyu
authors.initials: L
authors.lastname: Sun
authors.forename: Dongdong
authors.initials: D
authors.lastname: Yang
authors.forename: Huaming
authors.initials: H
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Ao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Jin
authors.forename: Qifan
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D017097:Electric Impedance; D004576:Electromyography; D005260:Female; D005767:Gastrointestinal Diseases / Q000503:physiopathology* / Q000601:surgery*; D056885:Interstitial Cells of Cajal / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D016065:Myoelectric Complex, Migrating; D010534:Peritoneal Neoplasms / Q000556:secondary*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*