title: [Expression of vascular endothelial growth factor and its significance in pulmonary bronchoalveolar carcinoma].
abstract: BACKGROUND
  To study the relationship between the vascular endothelial growth factor (VEGF) and the clinicopathological characteristics of the patients with pulmonary bronchoalveolar carcinoma, and to research the possible role of VEGF in the malignant growth of pulmonary bronchoalveolar carcinoma.
  
  
  METHODS
  The expression of VEGF and MVD were detected in 38 pulmonary bronchoalveolar carcinoma and 20 normal lung tissues by immunohistochemical method.
  
  
  RESULTS
  The positive rate of VEGF expression (73.68%,28/38) and MVD (63.81±19.26) in pulmonary bronchoalveolar carcinoma tissues were both remarkably higher than those in normal lung tissues (0, 18.44±6.53)( P < 0.005,P < 0.001). The positive rate of VEGF expression was significantly related to the size of tumor ( P < 0.05), lymphatic metastasis ( P < 0.025) and TNM stage ( P < 0.05), and so did the MVD ( P < 0.05, P < 0.05, P < 0.05). MVD was remarkably higher in VEGF (+) carcinoma tissues than that in VEGF (-) carcinoma tissues ( P < 0.05).
  
  
  CONCLUSIONS
  VEGF correlates with the clinicopathological characteristics of pulmonary bronchoalveolar carcinoma. It may play an important role in the development of pulmonary bronchoalveolar carcinoma.
authors.affiliation: Department of Thoracic Surgery, Navy General Hospital of PLA, Beijing 100037, P.R.China.
authors.forename: Weian
authors.initials: W
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Huasheng
authors.initials: H
authors.lastname: Wang
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Zhao