title: A primer on a hepatocellular carcinoma bioresource bank using the cancer genome atlas guidelines: practical issues and pitfalls.
abstract: BACKGROUND
  Since the advent of the human genome, the era of personalized genomic medicine is indisputably in progress.
  
  
  METHODS
  In an effort to contribute to the evolving knowledge of genomic medicine, we have aimed directly at building a bioresource bank for hepatocellular carcinoma. This tumor bank is based on the rigorous guidelines set forth by the National Cancer Institute, and it offers analytes to help elucidate the mechanisms of progression from cirrhosis to malignancy, risk factors for recurrence, and applicability of current treatment options to a diverse group of people.
  
  
  CONCLUSIONS
  Surgeons have a privileged position between patients (and their cancer) and the benches of basic science. Thus, we offer a primer based on our own experiences, from which surgeons may take elements to build their own bioresource bank for use in collaboration with others. We highlight some practicalities and pitfalls that could be overlooked, as well as a discussion of possible solutions.
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden Road, Suite #1500, BCM390, Houston, TX 77030, USA.
authors.forename: N Thao T
authors.initials: NT
authors.lastname: Nguyen
authors.forename: Ron T
authors.initials: RT
authors.lastname: Cotton
authors.forename: Theresa R
authors.initials: TR
authors.lastname: Harring
authors.forename: Jacfranz J
authors.initials: JJ
authors.lastname: Guiteau
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Gingras
authors.forename: David A
authors.initials: DA
authors.lastname: Wheeler
authors.forename: Christine A
authors.initials: CA
authors.lastname: O'Mahony
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gibbs
authors.forename: F Charles
authors.initials: FC
authors.lastname: Brunicardi
authors.forename: John A
authors.initials: JA
authors.lastname: Goss
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D003299:Cooperative Behavior; D030541:Databases, Genetic / Q000592:standards*; D030561:Databases, Nucleic Acid / Q000592:standards; D018450:Disease Progression; D005544:Forecasting; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human / Q000235:genetics*; D017408:Guidelines as Topic; D006801:Humans; D033183:Interdisciplinary Communication; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D054547:National Cancer Institute (U.S.); D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D057285:Precision Medicine / Q000639:trends*; D014015:Tissue Banks / Q000592:standards*; D014481:United States