title: Effect of total alkaloids from Commelina communis L. on lung damage by influenza virus infection.
abstract: Whether administration of total alkaloids from Commelina communis L. (TAC) reduces lung damage in influenza virus-infected mice was investigated. Compared with untreated mice, significantly less severe damage was found in the lungs of mice administered TAC at 8 mg/kg per day for 6 days. TAC significantly decreased viral loads in the lungs. The concentrations of IFN-γ in the serum of TAC-treated mice were significantly lower than those of virus control mice at 4 and 6 days post-infection. The results indicate that TAC imparted partial protection to the mice by reducing pulmonary viral loads and limiting lesions in the lungs.
authors.affiliation: Henan University of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Guo-Bin
authors.initials: GB
authors.lastname: Zhang
authors.forename: Fei-Hong
authors.initials: FH
authors.lastname: Bing
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Yi-Fan
authors.initials: YF
authors.lastname: Liao
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Chang-Yuan
authors.initials: CY
authors.lastname: Dong
mesh_terms: D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D034822:Commelina / Q000737:chemistry*; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis; D008168:Lung / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008517:Phytotherapy; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D000470:Alkaloids; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma