title: Knocking out angiotensin II in the heart.
abstract: Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are designed to target angiotensin II synthesis and function, but thus far, none have been able to completely block the effects of RAS signaling. This review discusses current and emerging approaches towards inhibiting cardiac RAS function in order to further improve cardiovascular disease outcomes.
authors.affiliation: Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA. zablocdk@umdnj.edu
authors.forename: Daniela
authors.initials: D
authors.lastname: Zablocki
authors.forename: Junichi
authors.initials: J
authors.lastname: Sadoshima
mesh_terms: D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D053818:Chymases / Q000378:metabolism; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D053818:Chymases; D012083:Renin