title: Assessment of a continuous blood gas monitoring system in animals during circulatory stress.
abstract: BACKGROUND
  The study was aimed to determine the measurement accuracy of The CDI™ blood parameter monitoring system 500 (Terumo Cardiovascular Systems Corporation, Ann Arbor MI) in the real-time continuous measurement of arterial blood gases under different cardiocirculatory stress conditions
  
  
  METHODS
  Inotropic stimulation (Dobutamine 2.5 and 5 μg/kg/min), vasoconstriction (Arginine-vasopressin 4, 8 and 16 IU/h), hemorrhage (-10%, -20%, -35%, and -50% of the theoretical volemia), and volume resuscitation were induced in ten swine (57.4 ± 10.7 Kg).Intermittent blood gas assessments were carried out using a routine gas analyzer at any experimental phase and compared with values obtained at the same time settings during continuous monitoring with CDI™ 500 system. The Bland-Altman analysis was employed.
  
  
  RESULTS
  Bias and precision for pO2 were - 0.06 kPa and 0.22 kPa, respectively (r2 = 0.96); pCO2 - 0.02 kPa and 0.15 kPa, respectively; pH -0.001 and 0.01 units, respectively ( r2 = 0.96). The analysis showed very good agreement for SO2 (bias 0.04,precision 0.33, r2 = 0.95), Base excess (bias 0.04,precision 0.28, r2 = 0.98), HCO3 (bias 0.05,precision 0.62, r2 = 0.92),hemoglobin (bias 0.02,precision 0.23, r2 = 0.96) and K+ (bias 0.02, precision 0.27, r2 = 0.93). The sensor was reliable throughout the experiment during hemodynamic variations.
  
  
  CONCLUSIONS
  Continuous blood gas analysis with the CDI™ 500 system was reliable and it might represent a new useful tool to accurately and timely monitor gas exchange in critically ill patients. Nonetheless, our findings need to be confirmed by larger studies to prove its reliability in the clinical setting.
authors.affiliation: Department of Heart and Vessels, Careggi Hospital, Florence, Italy. sandro.gelsomino@libero.it.
authors.forename: Sandro
authors.initials: S
authors.lastname: Gelsomino
authors.forename: Roberto
authors.initials: R
authors.lastname: Lorusso
authors.forename: Ugolino
authors.initials: U
authors.lastname: Livi
authors.forename: Stefano
authors.initials: S
authors.lastname: Romagnoli
authors.forename: Salvatore Mario
authors.initials: SM
authors.lastname: Romano
authors.forename: Rocco
authors.initials: R
authors.lastname: Carella
authors.forename: Fabiana
authors.initials: F
authors.lastname: Lucà
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Billè
authors.forename: Francesco
authors.initials: F
authors.lastname: Matteucci
authors.forename: Attilio
authors.initials: A
authors.lastname: Renzulli
authors.forename: Gil
authors.initials: G
authors.lastname: Bolotin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Cicco
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Stefàno
authors.forename: Jos
authors.initials: J
authors.lastname: Maessen
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Gensini