title: Control of ubiquitin conjugation by cdc48 and its cofactors.
abstract: Cdc48 (alias p97, VCP) is an important motor and regulator for the turnover of ubiquitylated proteins, both in proteasomal degradation and in nonproteolytic pathways. The diverse cellular tasks of Cdc48 are controlled by a large number of cofactors. Substrate-recruiting cofactors mediate the specific recognition of ubiquitylated target proteins, whereas substrate-processing cofactors often exhibit ubiquitin ligase or deubiquitylating activities that enable them to modulate the ubiquitylation state of substrates. This chapter introduces the major groups of Cdc48 cofactors and discusses the versatile options of substrate-processing cofactors to control the fate of Cdc48 substrates.
authors.affiliation: Department of Biochemistry, Biocenter, University of Würzburg, Am Hubland, 97074, Würzburg, Germany, alexanderbuchberger@biozentrum.uni-wuerzburg.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Buchberger
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D018797:Cell Cycle Proteins; D025801:Ubiquitin; D000251:Adenosine Triphosphatases