title: Chemotherapy-induced peripheral neuropathies: from clinical relevance to preclinical evidence.
abstract: BACKGROUND
  Chemotherapy-induced peripheral neuropathies (CIPN) are major dose-limiting side effects of many anticancer drugs. The incidence of CIPN varies from 10 to 100% depending on the anticancer drug. The characteristics of CIPN are related to dose intensity, cumulative dose and anticancer drug. CIPN can profoundly affect the quality-of-life, often compelling clinicians to lower the chemotherapy regimen, consequently limiting therapeutic efficacy.
  
  
  METHODS
  Relevant literature in the field is identified through a Medline search for articles published up to August 2010 with the keywords 'neuropathy', 'anticancer drugs' and 'pain'. This study considers original papers and reviews.
  
  
  CONCLUSIONS
  Neurotoxic anticancer drugs can affect specific peripheral nervous system structures (neuronopathy, axonopathy or myelinopathy) leading to CIPN, often with pain. Gaining deeper insights into neurotoxic mechanisms is critical to the development of new CIPN treatment and prevention strategies.
authors.affiliation: INSERM U766, Laboratoire de Toxicologie-Faculté de Pharmacie, Place Henri Dunant, F-63000 Clermont-Ferrand, France. dbalayssac@chu-clermontferrand.fr
authors.forename: David
authors.initials: D
authors.lastname: Balayssac
authors.forename: Jérémy
authors.initials: J
authors.lastname: Ferrier
authors.forename: Juliette
authors.initials: J
authors.lastname: Descoeur
authors.forename: Bing
authors.initials: B
authors.lastname: Ling
authors.forename: Denis
authors.initials: D
authors.lastname: Pezet
authors.forename: Alain
authors.initials: A
authors.lastname: Eschalier
authors.forename: Nicolas
authors.initials: N
authors.lastname: Authier
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents