title: Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae.
abstract: Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center, S525, P.O. Box 208031, 300 Cedar Street, New Haven, CT 06520-8031, USA. sarah.doernberg@ucsf.edu
authors.forename: Sarah
authors.initials: S
authors.lastname: Doernberg
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schaaf
authors.forename: Klaus
authors.initials: K
authors.lastname: Dalhoff
authors.forename: Lin
authors.initials: L
authors.lastname: Leng
authors.forename: Anna
authors.initials: A
authors.lastname: Beitin
authors.forename: Vincent
authors.initials: V
authors.lastname: Quagliarello
authors.forename: Richard
authors.initials: R
authors.lastname: Bucala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D008297:Male; D008586:Meningitis, Pneumococcal / Q000235:genetics* / Q000382:microbiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D008263:Macrophage Migration-Inhibitory Factors