title: LYP3, a new bestatin derivative for aminopeptidase N inhibition.
abstract: Aminopeptidase N (APN) is a ubiquitous enzyme overexpressed on tumor cells and plays an important role in angiogenesis and metastasis of tumor. Bestatin as an effective inhibitor of aminopeptidase N is used for complementary treatment of cancer with other drugs. In this work, we reformed the structure of bestatin to a new derivative LYP3 to improve the water solubility and effectiveness. The inhibitory activity of LYP3 against APN was evaluated in vitro.
authors.affiliation: Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, 250012 Ji'nan, Shandong, PR China. sunnyboyluan@yahoo.com.cn
authors.forename: Yepeng
authors.initials: Y
authors.lastname: Luan
authors.forename: Chunhua
authors.initials: C
authors.lastname: Ma
authors.forename: Zhongguo
authors.initials: Z
authors.lastname: Sui
authors.forename: Xuejian
authors.initials: X
authors.lastname: Wang
authors.forename: Jinhong
authors.initials: J
authors.lastname: Feng
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Fanbo
authors.initials: F
authors.lastname: Jing
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Fang
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu
mesh_terms: D018826:CD13 Antigens / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D007930:Leucine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020778:Matrix Metalloproteinase 2 / Q000737:chemistry / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy; D012995:Solubility
chemical_list: C558143:LYP3 compound; D061965:Matrix Metalloproteinase Inhibitors; D018826:CD13 Antigens; D020778:Matrix Metalloproteinase 2; D007930:Leucine; C012211:ubenimex