title: Acute kidney injury in older adults.
abstract: Aging kidneys undergo structural and functional changes that decrease autoregulatory capacity and increase susceptibility to acute injury. Acute kidney injury associates with duration and location of hospitalization, mortality risk, progression to chronic kidney disease, and functional status in daily living. Definition and diagnosis of acute kidney injury are based on changes in creatinine, which is an inadequate marker and might identify patients when it is too late. The incidence of acute kidney injury is rising and increases with advancing age, yet clinical studies have been slow to address geriatric issues or the heterogeneity in etiologies, outcomes, or patient preferences among the elderly. Here we examine some of the current literature, identify knowledge gaps, and suggest potential research questions regarding acute kidney injury in older adults. Answering these questions will facilitate the integration of geriatric issues into future mechanistic and clinical studies that affect management and care of acute kidney injury.
authors.affiliation: Section on Infectious Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, 100 Medical Center Boulevard, Winston-Salem, NC 27157-1042, USA.
authors.forename: Sharon
authors.initials: S
authors.lastname: Anderson
authors.forename: Basil
authors.initials: B
authors.lastname: Eldadah
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Halter
authors.forename: William R
authors.initials: WR
authors.lastname: Hazzard
authors.forename: Jonathan
authors.initials: J
authors.lastname: Himmelfarb
authors.forename: Frances McFarland
authors.initials: FM
authors.lastname: Horne
authors.forename: Paul L
authors.initials: PL
authors.lastname: Kimmel
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Molitoris
authors.forename: Mahadev
authors.initials: M
authors.lastname: Murthy
authors.forename: Ann M
authors.initials: AM
authors.lastname: O'Hare
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Schmader
authors.forename: Kevin P
authors.initials: KP
authors.lastname: High
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology; D008297:Male; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D003404:Creatinine