title: Expression of CD34 and CD105 as markers for angiogenesis in oral vascular malformations and pyogenic granulomas.
abstract: The objective of this study was to assess angiogenic activity by analyzing anti-CD105 and anti-CD34 immunostaining in 20 cases of vascular malformations (VMs) and 20 cases of oral pyogenic granulomas (OPG). In addition, the usefulness of these markers for the differential diagnosis of these two oral tumors was evaluated. The results showed no significant difference in mean microvessel count between the anti-CD105 (P = 0.803) and anti-CD34 (P = 0.279) antibody. The mean number of vessels was 18.75 and 59.72 for oral VMs immunostained with anti-CD105 and anti-CD34 antibody, respectively, whereas in OPG the mean number was 20.22 and 48.09, respectively. CD34 was found to be more effective than CD105 in identifying blood vessels. However, the anti-CD105 antibody seems to be more related to vascular neoformation. Overall, this study supports the role of angiogenic factors in the etiopathogenesis of oral VMs and PG, but the results showed that quantification of angiogenesis cannot be used as a marker for the differential diagnosis of these two types of lesions.
authors.affiliation: Oral Pathology Post-Graduate Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Marcelo Gadelha
authors.initials: MG
authors.lastname: Vasconcelos
authors.affiliation: Dentistry Departament, State's University of Paraíba, Campina Grande, PB, Brazil.
authors.forename: Pollianna Muniz
authors.initials: PM
authors.lastname: Alves
authors.affiliation: Oral Pathology Post-Graduate Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Rodrigo Gadelha
authors.initials: RG
authors.lastname: Vasconcelos
authors.affiliation: Oral Pathology Post-Graduate Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil. ericka_janine@yahoo.com.br.|Departamento de Odontologia, UFRN-Programa de Pós-Graduação em Patologia Oral, Av. Salgado Filho, 1787, Lagoa Nova, Natal, RN, 59056-000, Brazil. ericka_janine@yahoo.com.br.
authors.forename: Éricka Janine Dantas
authors.initials: ÉJD
authors.lastname: da Silveira
authors.affiliation: Oral Pathology Post-Graduate Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Ana Miryam Costa
authors.initials: AMC
authors.lastname: Medeiros
authors.affiliation: Oral Pathology Post-Graduate Program, Dentistry Departament, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Lélia Maria Guedes
authors.initials: LMG
authors.lastname: de Queiroz
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis* / Q000276:immunology; D018952:Antigens, CD34 / Q000096:biosynthesis* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000276:immunology; D003937:Diagnosis, Differential; D000071063:Endoglin; D005260:Female; D017789:Granuloma, Pyogenic / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply* / Q000276:immunology / Q000378:metabolism; D009062:Mouth Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000276:immunology* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000276:immunology; D054079:Vascular Malformations / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface