title: Immunohistochemical expression of Annexin A5 in preeclamptic placentas.
abstract: OBJECTIVE
  To study the expression of Annexin A5 (A5) in relation to preeclampsia using immunohistochemical Tissue Microarray (TMA) technique.
  
  
  METHODS
  Case-control study of 66 singleton preeclamptic (PE) patients matched for gestational age (GA) at delivery with 63 normotensive controls with normally grown fetuses. Immunohistochemical expression of A5 and other population characteristics were compared between the two groups using Chi-square, One-way ANOVA, Spearman's Correlation, and Linear Regression.
  
  
  RESULTS
  The two groups were similar for maternal age and rate of corticosteroid administration, but differed for nulliparity, Body Mass Index (BMI), blood pressure, presence of placental histological lesions, and placental weight. Expression of A5 was similar in PE and controls (p = 0.10); however it was found to be lower in PE cases complicated by fetal growth restriction (FGR, n = 34) compared with matched controls (n = 55) (p = 0.04). An inverse correlation was found between A5 and GA in cases but not in controls (p = 0.04 vs p = 0.71). The association was even more significant in the subgroup of PE complicated by FGR (p = 0.02). A5 expression was not influenced by blood pressure, proteinuria, or placental weight.
  
  
  CONCLUSIONS
  Annexin A5 expression seems to be related only to FGR and not to PE or its clinical severity.
authors.affiliation: Department of Obstetrics and Gynecology, University of Milano-Bicocca, Via Pergolesi 33, 20052 Monza, Italy. sara.ornaghi@virgilio.it
authors.forename: S
authors.initials: S
authors.lastname: Ornaghi
authors.forename: P
authors.initials: P
authors.lastname: Vergani
authors.forename: G
authors.initials: G
authors.lastname: Urban
authors.forename: V
authors.initials: V
authors.lastname: Giardini
authors.forename: F
authors.initials: F
authors.lastname: Moltrasio
authors.forename: B E
authors.initials: BE
authors.lastname: Leone
mesh_terms: D017304:Annexin A5 / Q000096:biosynthesis*; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies; D046888:Tissue Array Analysis
chemical_list: D017304:Annexin A5