title: Sonographic assessment of ceftriaxone-associated biliary pseudolithiasis in Chinese children.
abstract: In this randomized, single-blind, case-controlled, prospective study, the incidence and outcome of ceftriaxone-associated biliary pseudolithiasis in Chinese children was evaluated via ultrasonography. A total of 108 children diagnosed with hepatobiliary infection or pneumonia were randomized to receive ceftriaxone or ceftazidime. Serial gallbladder sonograms were obtained on days 1, 5 - 7 and 10 - 14 of therapy. Gallstones were detected in 43.10% of patients in the ceftriaxone-treated group and in 2.00% of the ceftazidime-treated group. The incidence of pseudolithiasis was significantly higher in the ceftriaxone-treated than the ceftazidime-treated group. Biliary precipitation abnormalities appeared after 2 - 7 days of treatment. After gallstones were found, the drug was stopped and symptoms resolved within 1 - 2 days. This study suggests that the risk of ceftriaxone-associated biliary pseudolithiasis should be considered when treating Chinese children.
authors.affiliation: Pharmaceutical Preparation Section, Third Affiliated Hospital, Third Military Medical University, Chongqing, China.
authors.forename: D
authors.initials: D
authors.lastname: Meng
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.forename: J
authors.initials: J
authors.lastname: Fu
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Tu
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D044466:Asian People; D001660:Biliary Tract Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002442:Ceftazidime / Q000627:therapeutic use; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D008297:Male; D011014:Pneumonia / Q000188:drug therapy; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D002442:Ceftazidime