title: Preclinical electrogastrography in experimental pigs.
abstract: Surface electrogastrography (EGG) is a non-invasive means of recording gastric myoelectric activity or slow waves from cutaneous leads placed over the stomach. This paper provides a comprehensive review of preclinical EGG. Our group recently set up and worked out the methods for EGG in experimental pigs. We gained our initial experience in the use of EGG in assessment of porcine gastric myoelectric activity after volume challenge and after intragastric administration of itopride and erythromycin. The mean dominant frequency in pigs is comparable with that found in humans. EGG in experimental pigs is feasible. Experimental EGG is an important basis for further preclinical projects in pharmacology and toxicology.
authors.affiliation: Institute of Experimental Biopharmaceutics, Joint Research Centre of Czech Academy of Sciences and PRO.MED.CS Praha as, Hradec Králové, Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Květina
authors.forename: Jithinraj
authors.initials: J
authors.lastname: Edakkanambeth Varayil
authors.forename: Shahzad Marghoob
authors.initials: SM
authors.lastname: Ali
authors.forename: Martin
authors.initials: M
authors.lastname: Kuneš
authors.forename: Jan
authors.initials: J
authors.lastname: Bureš
authors.forename: Ilja
authors.initials: I
authors.lastname: Tachecí
authors.forename: Stanislav
authors.initials: S
authors.lastname: Rejchrt
authors.forename: Marcela
authors.initials: M
authors.lastname: Kopáčová