title: Gene therapy for pulmonary hypertension: prospects and challenges.
abstract: BACKGROUND
  Recent evidence shows that pulmonary arterial hypertension (PAH) remains a fatal disease despite the introduction of new pharmacological treatments. New options are therefore needed and gene therapy approaches are a rational consideration based on emerging understanding of the genetic basis of PAH.
  
  
  METHODS
  This review briefly discusses the recent developments in clinical management of PAH and the investigation of gene delivery techniques for pulmonary vascular disease from 1997 to 2010, relating this to improved understanding of disease pathogenesis during this period. There is a focus on bone morphogenetic protein receptor type 2, as mutations in this gene are clearly linked to disease pathogenesis and outcomes. The reader will gain insight into the gene vector strategies being used, the target cells and the specific genes being delivered as candidate therapeutic approaches for PAH.
  
  
  CONCLUSIONS
  Various genes and strategies for delivery have achieved improvements in PAH in animal models, which is encouraging for the development of this technology for human application. The main limiting factor for clinical progress relates to gene delivery vector technology.
authors.affiliation: Royal Adelaide Hospital, Hanson Institute, Department of Thoracic Medicine, Lung Research Laboratory, University of Adelaide, Adelaide SA, Australia. paul.reynolds@adelaide.edu.au
authors.forename: Paul N
authors.initials: PN
authors.lastname: Reynolds
mesh_terms: D000818:Animals; D015316:Genetic Therapy; D006801:Humans; D006976:Hypertension, Pulmonary / Q000235:genetics / Q000628:therapy*