title: A pH/enzyme-responsive polymer film consisting of Eudragit FS 30 D and arabinoxylane as a potential material formulation for colon-specific drug delivery system.
abstract: Polymer film based on pH-dependent Eudragit FS 30 D acrylic polymer in association with arabinoxylane, a polysaccharide issued from gum psyllium, was produced by way of solvent casting. Physical-chemical characterization of the polymer film samples was performed by means of thermogravimetry (TGA), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Furthermore, water-equilibrium swelling index (I(s)) and weight loss of the films in KCl buffer solution of pH 1.2, in KH(2)PO(4) buffer solution of pH 5.0, or in KH(2)PO(4) buffer solution of pH 5.0 consisting of 4% enzyme Pectinex 3X-L (w/v) were also carried out for the film characterization. No chemical interactions between the Eudragit FS 30 D and the arabinoxylane polymer chains were evidenced, thus suggesting that the film-forming polymer structure was obtained from a physical mixture of both polymers. The arabinoxylane-loader films showed a more pronounced weight loss after their immersion in buffer solution containing enzyme Pectinex 3X-L. The introduction of the arabinoxylane makes the film more susceptible to undergo an enzymatic degradation. This meant that the enzyme-dependent propriety issued from the arabinoxylane has been imprinted into the film formulation. This type of polymer film is an interesting system for applications in colon-specific drug delivery system.
authors.affiliation: Laboratório de FarmacoTecnologia, Departamento de Farmacologia e Terapeutica Programa de Pós-graduação em Ciências Farmacêuticas, Maringá 87020-900, Brazil.
authors.forename: Mirela Fulgencio
authors.initials: MF
authors.lastname: Rabito
authors.forename: Adriano Valim
authors.initials: AV
authors.lastname: Reis
authors.forename: Adonilson dos Reis
authors.initials: Ados R
authors.lastname: Freitas
authors.forename: Elias Basile
authors.initials: EB
authors.lastname: Tambourgi
authors.forename: Osvaldo Albuquerque
authors.initials: OA
authors.lastname: Cavalcanti
mesh_terms: D002152:Calorimetry, Differential Scanning; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006867:Hydrolases / Q000378:metabolism; D011109:Polymethacrylic Acids / Q000737:chemistry* / Q000378:metabolism; D011620:Psyllium / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014990:Xylans / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; D014990:Xylans; C038300:methylmethacrylate-methacrylic acid copolymer; D011620:Psyllium; D006867:Hydrolases