title: Continuum electromechanical modeling of protein-membrane interactions.
abstract: A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system. The model couples the macroscopic strain energy of membrane and the electrostatic solvation energy of the system, and equilibrium membrane deformation is obtained by minimizing the electroelastic energy functional with respect to the dielectric interface. The model is illustrated with the systems with increasing geometry complexity and captures the sensitivity of membrane curvature to the permanent and mobile charge distributions.
authors.affiliation: Department of Mathematics, Colorado State University, Fort Collins, Colorado 80523, USA. yzhou@math.colostate.edu
authors.forename: Y C
authors.initials: YC
authors.lastname: Zhou
authors.forename: Benzhuo
authors.initials: B
authors.lastname: Lu
authors.forename: Alemayehu A
authors.initials: AA
authors.lastname: Gorfe
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D004560:Electricity; D055595:Mechanical Phenomena; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D056004:Molecular Dynamics Simulation; D017711:Nonlinear Dynamics; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015203:Reproducibility of Results; D012997:Solvents / Q000737:chemistry; D055672:Static Electricity
chemical_list: D008565:Membrane Proteins; D012997:Solvents