title: Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides.
abstract: Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amides via transamidation.
authors.affiliation: Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, UK WC1H 0AJ.
authors.forename: Pavel
authors.initials: P
authors.lastname: Starkov
authors.forename: Tom D
authors.initials: TD
authors.lastname: Sheppard