title: Control of NF-κB and inflammation by the unfolded protein response.
abstract: Under inflammatory situations, endoplasmic reticulum (ER) stress occurs at local sites and modulates inflammatory processes. NF-κB is a key regulator for immune and inflammatory responses, and its activity is influenced by ER stress positively or negatively. Recent investigation suggested that ER stress induces activation of NF-κB in the early phase, whereas in the later phase, consequent unfolded protein response (UPR) inhibits NF-κB. This review summarizes current knowledge on potential mechanisms underlying the biphasic, bidirectional regulation of NF-κB by the UPR and possible roles for ER stress in the regulation of inflammation.
authors.affiliation: Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan. masanori@yamanashi.ac.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Kitamura
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D015536:Down-Regulation; D004721:Endoplasmic Reticulum / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D018384:Oxidative Stress / Q000276:immunology; D051381:Rats; D015398:Signal Transduction / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology / Q000378:metabolism; D056811:Unfolded Protein Response / Q000276:immunology*; D015854:Up-Regulation
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D014157:Transcription Factors