title: [WT1 peptide pulsed dendritic cell therapy with activated T lymphocytes therapy for advanced cancers].
abstract: We assessed the efficacy of WT1 peptide pulsed dendritic cell (DC) therapy for various advanced cancers. All patients were vaccinated 5 times for 10 weeks with autologous monocytes derived DC and activated T lymphocytes. We treated a total of 26 patients who had HLA-A2402 or/and HLA-A0201. We evaluated 20 of the 26 patients who finished 5-time vaccination (10 men and 10 women, aged 48-81 years, Mean 64 years) and were diagnosed as follows: 3-pancreas cancer, 2-colorectal, 2-breast, 2-esophageal, 2-lung, 2-uterus, 2-ovarian and 5 others. In Clinical response (RECIST), the result was assessed as CR/PR/SD/PD, 0/7/8/5, respectively. Furthermore, the 7 PRs were resulted from 2-colorectal, and one of each was lung, laryngeal, axis, pancreas and smooth muscle sarcoma cancer. The 4 of 7 PR patients were treated with chemotherapy.
authors.affiliation: Shin-Yokohama Kato Clinic.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kato
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000008:administration & dosage*; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D010844:Picibanil / Q000627:therapeutic use; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D025721:WT1 Proteins / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D025721:WT1 Proteins; D010844:Picibanil