title: [A case of squamous cell carcinoma of the anal cancer with associated human immunodeficiency virus].
abstract: A 62-year-old man with internal piles tested positive for infection with HIV and was admitted to our hospital. He presented with an anal tumor with bilateral inguinal nodal metastasis and pain in the anus; the tumor was diagnosed as stage IIIb (cA1N2M0). The patient's immune system was unstable. Therefore, he was administered chemoradiotherapy [low dose 5-fluorouracil plus cisplatin (FP) and radiotherapy (RT)] following HAART. Chemoradiotherapy resulted in complete response. However, CT performed 2 years after the diagnosis showed a recurrence in the hilar and mediastinal lymph node. The patient was administered chemotherapy with 5-fluorouracil and cisplatin (5-FU/CDDP) to the metastatic lymph node. However, the treatment response was graded as progressive disease, and the treatment was changed from CDDP to mitomycin C (MMC). The patient developed non-hematologic toxicity and died within 3 years of the diagnosis. We report a case of squamous cell carcinoma of the anus with associated HIV infection.
authors.affiliation: Dept. of Surgery, National Hospital Organization, Osaka National Hospital.
authors.forename: Kiyomichi
authors.initials: K
authors.lastname: Sueda
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikenaga
authors.forename: Michihiko
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yasui
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mishima
authors.forename: Masanori
authors.initials: M
authors.lastname: Tsujie
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Omiya
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyamoto
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hirao
authors.forename: Koji
authors.initials: K
authors.lastname: Takami
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Fujitani
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshida
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tsujinaka
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D023241:Antiretroviral Therapy, Highly Active; D001005:Anus Neoplasms / Q000150:complications* / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil