title: Bathymodiolamides A and B, ceramide derivatives from a deep-sea hydrothermal vent invertebrate mussel, Bathymodiolus thermophilus.
abstract: Two ceramide derivatives, bathymodiolamides A (1) and B (2), were isolated from the deep-sea hydrothermal vent invertebrate mussel Bathymodiolus thermophilus. The molecular structures of these compounds were determined using a combination of NMR spectroscopy, mass spectrometry, and chemical degradation. Biological activities were assessed in a ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent mussel B. thermophilus.
authors.affiliation: Center for Marine Biotechnology, Institute of Marine and Coastal Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901-8521, USA.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Andrianasolo
authors.forename: Liti
authors.initials: L
authors.lastname: Haramaty
authors.forename: Kerry L
authors.initials: KL
authors.lastname: McPhail
authors.forename: Eileen
authors.initials: E
authors.lastname: White
authors.forename: Costantino
authors.initials: C
authors.lastname: Vetriani
authors.forename: Paul
authors.initials: P
authors.lastname: Falkowski
authors.forename: Richard
authors.initials: R
authors.lastname: Lutz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D049872:Bivalvia / Q000737:chemistry*; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D019311:Staurosporine / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D002518:Ceramides; C559017:bathymodiolamide A; C559016:bathymodiolamide B; D019311:Staurosporine