title: P-glycoprotein expression, tumor weight, age, and relapse in patients with stage I and II favorable-histology Wilms' tumor.
abstract: Fifteen percent of patients with Wilms' tumor (WT) experience relapse. It has been suggested that weight and age may affect the chances of relapse. Few studies have investigated the role, if any, between P-glycoprotein (P-gp) and relapse. The authors assessed the prognostic value of tumor weight and age at diagnosis and asked whether some other potential biological markers, specifically P-gp protein expression, had a prognostic value in favorable-histology WT. No association between age and relapse could be found. Patients with tumor weight ≥550 g were 6 times more likely to relapse, whereas P-gp expression was positive in 18/40 (45%) of the patients, of which 10/12 (83.3%) relapsed and 8/28 (28.6%) did not. Further studies are necessary to elucidate whether or not P-gp is related to relapse in patients with histologically favorable Wilms' tumor. If confirmed, the protein may be used in the future as a target for new drugs and treatments for this group of patients.
authors.affiliation: Department of Pediatric Oncology and Hematology, Universidade de São Paulo São Paulo, Brazil. rapteixeira@uol.com.br
authors.forename: Roberto Augusto Plaza
authors.initials: RA
authors.lastname: Teixeira
authors.forename: Vicente
authors.initials: V
authors.lastname: Odone-Filho
authors.forename: Beatriz
authors.initials: B
authors.lastname: de Camargo
authors.forename: Maria Claudia
authors.initials: MC
authors.lastname: Zerbini
authors.forename: Renne
authors.initials: R
authors.lastname: Fillipi
authors.forename: Arlaine
authors.initials: A
authors.lastname: Alencar
authors.forename: Lilian
authors.initials: L
authors.lastname: Cristofani
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D047368:Tumor Burden; D009396:Wilms Tumor / Q000378:metabolism* / Q000473:pathology*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1