title: Role of hemopoietic precursors of various classes in the effect of granulocyte colony-stimulating factor on hemopoiesis during cytostatic-induced myelosuppression.
abstract: Experiments were performed on the model of cyclophosphamide-induced myelosuppression. We showed that regeneration of the granulocytic hemopoietic stem is related to activation of multipotent, granulocyte-erythroid-macrophage-megakaryocyte, and granulocyte-macrophage precursors. The division and maturation of granulocyte colony-forming cells and significant decrease in the number of these cells in the bone were suppressed under these conditions. The granulocytopoiesis-stimulating effect of granulocyte CSF during myelosuppression was associated with an increase in functional activity of multipotent and granulocyte-erythroid-macrophage-megakaryocyte precursors (primarily of differentiation). In the period of regeneration, this effect was attributed to activity of granulocyte precursors.
authors.affiliation: Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: E G
authors.initials: EG
authors.lastname: Skurikhin
authors.forename: O V
authors.initials: OV
authors.lastname: Pershina
authors.forename: T V
authors.initials: TV
authors.lastname: Andreeva
authors.forename: E S
authors.initials: ES
authors.lastname: Khmelevskaya
authors.forename: M Ju
authors.initials: MJ
authors.lastname: Minakova
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide; D054697:Cytostatic Agents / Q000494:pharmacology; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects; D051379:Mice; D012038:Regeneration / Q000187:drug effects
chemical_list: D054697:Cytostatic Agents; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide