title: West nile virus RNA not detected in urine of 40 people tested 6 years after acute West Nile virus disease.
abstract: West Nile virus (WNV) causes an acute infection that is usually cleared by an effective immune response after several days of viremia. However, a recent study detected WNV RNA in the urine of 5 of 25 persons (20%) tested several years after their initial acute WNV disease. We evaluated an established cohort of 40 persons >6 years after initial infection with WNV. Urine collected from all participants tested negative for WNV RNA by reverse-transcription polymerase chain reaction and transcription-mediated amplification. Prospective studies are needed to determine if and for how long WNV persists in urine following WNV disease.
authors.affiliation: Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA.
authors.forename: Katherine B
authors.initials: KB
authors.lastname: Gibney
authors.forename: Robert S
authors.initials: RS
authors.lastname: Lanciotti
authors.forename: James J
authors.initials: JJ
authors.lastname: Sejvar
authors.forename: C Thomas
authors.initials: CT
authors.lastname: Nugent
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Linnen
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Delorey
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Lehman
authors.forename: Erin N
authors.initials: EN
authors.lastname: Boswell
authors.forename: J Erin
authors.initials: JE
authors.lastname: Staples
authors.forename: Marc
authors.initials: M
authors.lastname: Fischer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000235:genetics / Q000652:urine*; D014901:West Nile Fever / Q000652:urine* / Q000821:virology*; D014902:West Nile virus / Q000235:genetics*; D055815:Young Adult
chemical_list: D012367:RNA, Viral