title: Toroidal coil chromatography: the effect of scale-up and "g" field on stage efficiency.
abstract: Selected test results have been taken from various publications and resolution and stage efficiency measured using an established model. All experiments used the same sample and, where possible, the same sample loading. The results show that stage mixing efficiencies have increased from 1.1% in 1998 to greater than 25% in the latest scaled-up version of a Toroidal coil chromatography (TCC) instrument working at 240 g.
authors.affiliation: Brunel Institute for Bioengineering, Brunel University, Kingston Lane, Uxbridge, Middlesex UB83PH, UK. ian.sutherland@brunel.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Sutherland
authors.forename: Peter
authors.initials: P
authors.lastname: Hewitson
authors.forename: Joost
authors.initials: J
authors.lastname: de Folter
mesh_terms: D002845:Chromatography / Q000295:instrumentation / Q000379:methods*; D009113:Muramidase / Q000302:isolation & purification*; D009211:Myoglobin / Q000302:isolation & purification*
chemical_list: D009211:Myoglobin; D009113:Muramidase