title: An unusual case of aplastic anemia caused by temozolomide.
abstract: Radiotherapy and concomitant/adjuvant therapy with temozolomide are a common treatment regimen for children and adults with high-grade glioma. Although temozolomide is generally safe, it can rarely cause life-threatening complications. Here we report a case of a 31-year-old female patient who underwent surgical resection followed by radiotherapy plus concomitant temozolomide. She developed pancytopenia after adjuvant treatment with temozolomide. A bone marrow aspiration and biopsy showed hypocellularity with very few erythroid and myeloid cells, consistent with aplastic anemia. In the English literature, aplastic anemia due to temozolomide is extremely rare.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey.
authors.forename: Gazi
authors.initials: G
authors.lastname: Comez
authors.forename: Alper
authors.initials: A
authors.lastname: Sevinc
authors.forename: Ozlem Nuray
authors.initials: ON
authors.lastname: Sever
authors.forename: Taner
authors.initials: T
authors.lastname: Babacan
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sarı
authors.forename: Celalettin
authors.initials: C
authors.lastname: Camci