title: Synthesis and antiproliferative activity of new coumarin-based benzopyranone derivatives against human tumor cell lines.
abstract: The synthesis and antiproliferative activity of new coumarin-based benzopyranone derivatives containing basic amino side chain are described. The cytotoxicities against A549 and MCF-7 human cancerous cell lines were determined after 24, 48, 72 h drug exposure employing MTT assay at concentrations ranging from 0-100 μM. The antiproliferative activities of these compounds were compared to tamoxifen (TAM), 4-hydroxytamoxifen (4-OHT), raloxifene (RAL), 17β-estradiol (E2) and Diethylstilbestrol (DES). In vitro results indicated that compounds 10 and 12 were the most potent showing significant inhibitory activities against these cell lines. Furthermore, their antiproliferative activity against MCF-7 human breast cancer cell line is comparable to that of TAM, RAL and 4-OHT.
authors.affiliation: Department of Chemistry, Florida A & M University, 219 Jones Halls, Tallahassee, FL 32307, USA. musiliyu.musa@famu.edu
authors.forename: Musiliyu A
authors.initials: MA
authors.lastname: Musa
authors.forename: Ailing
authors.initials: A
authors.lastname: Zhou
authors.forename: Omowunmi A
authors.initials: OA
authors.lastname: Sadik
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins