title: A nuclear magnetic resonance approach to the comparison of mucoadhesive properties of polysaccharides for ophthalmic uses.
abstract: Mucoadhesive properties of tamarind seed polysaccharide (TSP) and larch arabinogalactan (AG), which are developed for ophthalmic applications, were investigated by NMR spectroscopy. Polysaccharide to mucin affinities were compared by using ketotifen fumarate as low molecular weight interaction probe. Proton selective relaxation rate measurements revealed enhanced affinity of TSP to mucin with respect to AG.
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgimento 35, I-56126 Pisa, Italy. gub@dcci.unipi.it
authors.forename: Gloria
authors.initials: G
authors.lastname: Uccello-Barretta
authors.forename: Samuele
authors.initials: S
authors.lastname: Nazzi
authors.forename: Federica
authors.initials: F
authors.lastname: Balzano
authors.forename: Marco
authors.initials: M
authors.lastname: Sansò
mesh_terms: D000268:Adhesiveness; D005685:Galactans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007665:Ketotifen / Q000008:administration & dosage / Q000737:chemistry; D028221:Larix / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009077:Mucins / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification; D012639:Seeds / Q000737:chemistry; D029861:Tamarindus / Q000737:chemistry
chemical_list: D005685:Galactans; D009077:Mucins; D009883:Ophthalmic Solutions; D011134:Polysaccharides; C005653:arabinogalactan; D007665:Ketotifen