title: [Intravenous administration of lipids in poisoning caused by local analgesics].
abstract: OBJECTIVE
  To draw attention to the use of intravenous lipids in the treatment of cardiac arrests caused by overdosage of lipophilic drugs. Case reports and animal studies have shown beneficial use of lipids in severe intoxication. The literature is reviewed.
  
  
  CONCLUSIONS
  Lipids have a place in the treatment of severe cardiac events caused by local analgesics for regional anaesthesia. Lipids should be readily available when regional anaesthesia is performed. National guidelines should be prepared. Lipids may also be an option in the treatment of intoxication with other lipophilic drugs.
authors.affiliation: Anastesiologisk Afdeling, Hillerod Hospital, Denmark. martins@nypost.dk
authors.forename: Martin
authors.initials: M
authors.lastname: Skjønnemand
authors.forename: Jens
authors.initials: J
authors.lastname: Damgaard-Jensen
authors.forename: Bo
authors.initials: B
authors.lastname: Gottschau
mesh_terms: D000765:Anesthesia, Conduction; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D062787:Drug Overdose; D004655:Emulsions / Q000008:administration & dosage / Q000627:therapeutic use; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D006323:Heart Arrest / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D010743:Phospholipids / Q000008:administration & dosage / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D012151:Resuscitation / Q000379:methods; D013024:Soybean Oil / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil