title: The grape antioxidant resveratrol for skin disorders: promise, prospects, and challenges.
abstract: Resveratrol, a phytoalexin antioxidant found in red grapes, has been shown to have both chemopreventive and therapeutic effects against many diseases and disorders, including those of the skin. Studies have shown protective effects of resveratrol against ultraviolet radiation-mediated oxidative stress and cutaneous damages including skin cancer. Because many of the skin conditions stem from ultraviolet radiation and oxidative stress, this antioxidant appears to have promise and prospects against a wide range of cutaneous disorders including skin aging and skin cancers. However, there are a few roadblocks in the way of this promising agent regarding its translation from the bench to the bedside. This review discusses the promise and prospects of resveratrol in the management of skin disorders and the associated challenges.
authors.affiliation: Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Ndiaye
authors.forename: Carol
authors.initials: C
authors.lastname: Philippe
authors.forename: Hasan
authors.initials: H
authors.lastname: Mukhtar
authors.forename: Nihal
authors.initials: N
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D000077185:Resveratrol; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use*; D027843:Vitis / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol