title: Immunohistochemical analysis of aquaporins in the fetal and adult vocal fold.
abstract: OBJECTIVE
  The purpose of this study is to identify and compare the presence and location of aquaporins in the fetal and adult larynx using immunohistochemical techniques.
  
  
  METHODS
  Immunohistochemical staining was performed on adult and fetal true vocal fold specimens. The presence and location of aquaporins -1, -2 and -3 in the fetal specimens were then compared to the adult specimens.
  
  
  RESULTS
  Immunohistochemical analysis revealed a homogenous distribution of aquaporin -3 in the cell cytoplasm of adult lamina propria with a higher concentration in the superficial layer. Aquaporins -1 and -2 were not identified in either the adult specimens. No evidence of aquaporins were identified in the fetal lamina propria.
  
  
  CONCLUSIONS
  Aquaporin -3 was found in the lamina propria of adult true vocal cord specimens with a higher concentration in the superficial layer. No evidence of Aquaporins -1, -2, or -3 was found in fetal specimens.
authors.affiliation: Department of Otolaryngology and Communicative Sciences, Department of Pathology, University of Mississippi Medical Center, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Goodier
authors.forename: Aimee P
authors.initials: AP
authors.lastname: Goodier
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Brown
authors.forename: John
authors.initials: J
authors.lastname: Schweinfurth
mesh_terms: D000328:Adult; D020346:Aquaporins / Q000378:metabolism*; D002102:Cadaver; D005333:Fetus; D006801:Humans; D007150:Immunohistochemistry; D014827:Vocal Cords / Q000378:metabolism*
chemical_list: D020346:Aquaporins