title: Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis.
abstract: BACKGROUND
  Pseudomonas aeruginosa in the sinuses plays a role in the lungs in cystic fibrosis (CF) patients, but little is known about the sinus environment where the bacteria adapt. Anoxic areas are found in the lower respiratory airways but it is unknown if the same conditions exist in the sinuses.
  
  
  METHODS
  The oxygen tension (pO(2)) was measured, using a novel in vivo method, in the maxillary sinus in a group of 20 CF patients.
  
  
  RESULTS
  The CF patients had a significant lower pO(2) on the mucosa but not in the sinus lumen as compared with a control group of non-CF patients. Anoxic conditions were found in 7/39 (18%) of the sinuses from where we cultured P. aeruginosa, Stenotrophomonas maltophilia and/or coagulase negative staphylococci.
  
  
  CONCLUSIONS
  These findings support our hypothesis that P. aeruginosa can adapt or acclimate to the environment in the lungs, during growth in anoxic parts of the paranasal sinuses.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Rigshospitalet, Denmark. Blegdamsvej 9, DK-2100 Copenhagen, Denmark. kasperaanaes@hotmail.com
authors.forename: Kasper
authors.initials: K
authors.lastname: Aanaes
authors.forename: Lars Fledelius
authors.initials: LF
authors.lastname: Rickelt
authors.forename: Helle Krogh
authors.initials: HK
authors.lastname: Johansen
authors.forename: Christian
authors.initials: C
authors.lastname: von Buchwald
authors.forename: Tacjana
authors.initials: T
authors.lastname: Pressler
authors.forename: Niels
authors.initials: N
authors.lastname: Høiby
authors.forename: Peter Østrup
authors.initials: PØ
authors.lastname: Jensen
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D008443:Maxillary Sinus / Q000378:metabolism* / Q000382:microbiology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism* / Q000382:microbiology; D010100:Oxygen / Q000378:metabolism*; D011552:Pseudomonas Infections / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000378:metabolism*; D055815:Young Adult
chemical_list: D010100:Oxygen