title: Anaphylactic reaction to different gonadotropin-releasing hormone agonists for the treatment of endometriosis.
abstract: Anaphylactic reactions to gonadotropin-releasing hormone (GnRH) agonists are exceedingly rare, but if they occur, they can be life threatening. This case describes a 33-year-old patient with endometriosis who developed an acute allergic reaction on leuprolide (Lucrin) administration. Although skin tests with the replacement goserelin (Zoladex) were negative, usage of this medication resulted in a similar allergic reaction. This is the first case report that shows that, in case of a proven allergy to one GnRH agonist, a switch to another GnRH agonist should not be made even if allergy tests are negative for this medication.
authors.affiliation: Department of Reproductive Medicine, Endometriosis Center, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Annemarie B
authors.initials: AB
authors.lastname: Lüchinger
authors.forename: Velja
authors.initials: V
authors.lastname: Mijatovic
authors.forename: Thomas
authors.initials: T
authors.lastname: Rustemeyer
authors.forename: Peter G A
authors.initials: PG
authors.lastname: Hompes
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis* / Q000188:drug therapy; D018926:Anti-Allergic Agents / Q000627:therapeutic use; D002974:Clemastine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000627:therapeutic use; D017273:Goserelin / Q000008:administration & dosage / Q000009:adverse effects*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018926:Anti-Allergic Agents; D006634:Histamine H1 Antagonists; D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone; D002974:Clemastine; D016729:Leuprolide