title: Metabolism, migration and memory in cytotoxic T cells.
abstract: The transcriptional and metabolic programmes that control CD8(+) T cells are regulated by a diverse network of serine/threonine kinases. The view has been that the kinases AKT and mammalian target of rapamycin (mTOR) control T cell metabolism. Here, we challenge this paradigm and discuss an alternative role for these kinases in CD8(+) T cells, namely to control cell migration. Another emerging concept is that AMP-activated protein kinase (AMPK) family members control T cell metabolism and determine the effector versus memory fate of CD8(+) T cells. We speculate that one link between metabolism and immunological memory is provided by kinases that originally evolved to control T cell metabolism and have subsequently acquired the ability to control the expression of key transcription factors that regulate CD8(+) T cell effector function and migratory capacity.
authors.affiliation: Division of Cell Biology and Immunology, University of Dundee, Dundee, UK.
authors.forename: David
authors.initials: D
authors.lastname: Finlay
authors.forename: Doreen A
authors.initials: DA
authors.lastname: Cantrell
mesh_terms: D002465:Cell Movement; D006801:Humans; D007156:Immunologic Memory; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology* / Q000276:immunology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: C546842:MTOR protein, human; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases