title: [Male breast cancer: a pairing comparison of survival with women breast cancer].
abstract: OBJECTIVE
  To investigate clinicopathological characteristics of male breast cancer patients and women breast cancer patients, compare disease-free survival and overall survival in a group of matched men and women with breast cancer.
  
  
  METHODS
  The clinical data and survival status of 45 cases operable male breast cancer treated in our hospital from 1982.9 to 2006.12 were collected. Each man with breast cancer recorded in the database was matched with two women. Matching was done based on age, year of diagnosis, stage and pathology. SPSS16.0 software was used for statistic treatment. Chi-square test was used for the comparison of frequency data between groups. Kaplan-Meier method was applied to analyze survivals. And Log-Rank was used to compare curves between groups. Statistical significance was considered at P < 0.05.
  
  
  RESULTS
  The 45 male breast cancer patients were matched with 90 female patients. The median age at diagnosis was 59 (26 ∼ 75) years for men and 57 (22 ∼ 76) years for women. The median follow-up was 61 (5 ∼ 262) months for men and 71 (29 ∼ 283) months for women. Mass location, receptor status, chemotherapy and hormonal therapy were statistically significant between male BC and female BC groups. About male BC patients, monofactorial analysis showed tumor size, lymph node state and TNM stage were prognostic factors. The 5-year disease-free survival of male BC and women BC were respectively 62.3% and 78.8%, 10-year DFS were 35.3% and 45.3%;The 5-year overall survival of male BC and female BC were respectively 70.5% and 82.5%, 10-year OS were 42.8%and 62.4%.
  
  
  CONCLUSIONS
  After the matching of age, year of diagnosis, stage and pathology, the prognosis for men with breast carcinoma is significantly poor comparing with women. We should play more emphasize on early diagnosis and early therapy, and think highly of chemotherapy and hormonal therapy to improve the prognosis of male BC patients.
authors.affiliation: Department of Breast Cancer, Tianjin Medical University, Tianjin 300060, China.
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Liu
authors.forename: Zhong-sheng
authors.initials: ZS
authors.lastname: Tong
authors.forename: Chun-fang
authors.initials: CF
authors.lastname: Hao
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality; D018567:Breast Neoplasms, Male / Q000175:diagnosis* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult