title: Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine.
abstract: BACKGROUND
  Posttraumatic stress disorder (PTSD) is associated with altered concentrations of stress-related neurohormones, neurotrophins, and neuropeptides in plasma and serum; however, few studies have examined central alterations of these measures in individuals with PTSD. Furthermore, no study to date has evaluated the effects of successful antidepressant treatment on cerebrospinal fluid (CSF) abnormalities in PTSD.
  
  
  METHODS
  Sixteen medication-free outpatients with chronic PTSD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) due to physical and/or sexual abuse or motor vehicle accidents (mean ± SD age = 36 ± 11.4 years, 12 women) and 11 nontraumatized healthy subjects (mean ± SD age = 35.3 ± 13.1 years, 7 women) underwent a lumbar puncture for collection of CSF. Seven PTSD patients had a repeat lumbar puncture 12 weeks later, after successful treatment of PTSD with paroxetine. CSF was analyzed for corticotropin-releasing factor (CRF), interleukin-6 (IL-6), brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and substance P concentrations. The study was conducted between January 2003 and August 2004.
  
  
  RESULTS
  Compared to nontraumatized healthy controls, patients with chronic PTSD had similar pretreatment concentrations of CSF CRF, IL-6, BDNF, IGF-1, and substance P. Posttreatment CSF measures did not change significantly in patients whose symptoms remitted with paroxetine.
  
  
  CONCLUSIONS
  Chronic, moderate PTSD due to civilian trauma, without psychotic symptoms and without significant rates of comorbid depression, alcohol dependence, or substance dependence, is not associated with abnormalities in CSF CRF, IL-6, BDNF, IGF-1, or substance P levels. Despite substantial reduction in PTSD symptoms, antidepressant treatment does not alter normal central concentrations of these neurochemicals, with the possible exception of substance P.
authors.affiliation: Department of Psychiatry, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel 91120. bonne@hadassah.org.il
authors.forename: Omer
authors.initials: O
authors.lastname: Bonne
authors.forename: Jessica Mary
authors.initials: JM
authors.lastname: Gill
authors.forename: David A
authors.initials: DA
authors.lastname: Luckenbaugh
authors.forename: Carlos
authors.initials: C
authors.lastname: Collins
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owens
authors.forename: Salvadore
authors.initials: S
authors.lastname: Alesci
authors.forename: Alexander
authors.initials: A
authors.lastname: Neumeister
authors.forename: Peixiong
authors.initials: P
authors.lastname: Yuan
authors.forename: Becky
authors.initials: B
authors.lastname: Kinkead
authors.forename: Huesseni K
authors.initials: HK
authors.lastname: Manji
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Charney
authors.forename: Meena
authors.initials: M
authors.lastname: Vythilingam
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid*; D002908:Chronic Disease; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000134:cerebrospinal fluid*; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects / Q000627:therapeutic use*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics; D013313:Stress Disorders, Post-Traumatic / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D013373:Substance P / Q000134:cerebrospinal fluid*; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D019208:Brain-Derived Neurotrophic Factor; D015850:Interleukin-6; D013373:Substance P; D017374:Paroxetine; D007334:Insulin-Like Growth Factor I; D003346:Corticotropin-Releasing Hormone