title: Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain.
abstract: In 2009 a novel H1N1 influenza virus emerged and spread rapidly. Soon after vaccine lots were released, however, the shelf life was revised downward due to an unexpected decrease in HA potency. In this study, we found differences in both stability and antigenic content of two monovalent H1N1/2009 vaccine preparations. These appear to have arisen due to differences in the A/California/7/2009-like influenza strain used to prepare vaccine.
authors.affiliation: Centre for Vaccine Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Ottawa, Canada. aaron.farnsworth@hc-sc.gc.ca
authors.forename: Aaron
authors.initials: A
authors.lastname: Farnsworth
authors.forename: Terry D
authors.initials: TD
authors.lastname: Cyr
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
authors.forename: Junzhi
authors.initials: J
authors.lastname: Wang
authors.forename: Xuguang
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry* / Q000276:immunology; D002645:Chickens; D004355:Drug Stability; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000737:chemistry* / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control; D055550:Protein Stability; D017433:Protein Structure, Secondary; D016865:Reassortant Viruses / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines