title: Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex.
abstract: OBJECTIVE
  The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome.
  
  
  METHODS
  A single-center, retrospective analysis was performed of patients with documented TSC seen from 1988 to 2010 at the Children's Memorial Health Institute, Warsaw, Poland.
  
  
  RESULTS
  Sixty-two patients were analyzed, and there was a significant correlation between younger age at the first seizure and developmental delay. The patients who did not develop seizures had normal development, despite some presenting with higher tuber load than those with seizures. There was a statistically significant negative correlation between the number of tubers within the right temporal lobe and cognition.
  
  
  CONCLUSIONS
  Our findings confirm our hypothesis that the cognitive outcome in TSC is more dependent on the age of the seizure onset rather than on the tuber count.
authors.affiliation: Department of Neurology Radiology, MR Unit Pediatric Rehabilitation Psychology, The Children's Memorial Health Institute, Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kaczorowska
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Jurkiewicz
authors.forename: Dorota
authors.initials: D
authors.lastname: Domańska-Pakieła
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Syczewska
authors.forename: Barbara
authors.initials: B
authors.lastname: Lojszczyk
authors.forename: Dariusz
authors.initials: D
authors.lastname: Chmielewski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kotulska
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kuczyński
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kmieć
authors.forename: Dorota
authors.initials: D
authors.lastname: Dunin-Wąsowicz
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kasprzyk-Obara
authors.forename: Sergiusz
authors.initials: S
authors.lastname: Jóźwiak
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D007360:Intelligence / Q000502:physiology*; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000473:pathology* / Q000523:psychology*; D014888:Wechsler Scales; D055815:Young Adult