title: Is static magnetic field exposure a new model of metabolic alteration? Comparison with Zucker rats.
abstract: OBJECTIVE
  The aim of this study was to investigate if the metabolic alterations observed after static magnetic field (SMF) exposure participates in the development of a pre-diabetic state. A comparison study using the insulin resistant animal model, the Zucker rat and the SMF-exposed Wistar rat was carried out.
  
  
  METHODS
  Zucker rats were compared to Wistar rats either exposed to a 128 mT or 0 mT SMF (sham exposed) and analysed. This moderate-intensity SMF exposure of Wistar rats was performed for 1 h/day during 15 consecutive days.
  
  
  RESULTS
  Wistar rats exposed to the SMF showed increased levels of carbohydrate and lipid metabolites (i.e., lactate, glycerol, cholesterol and phospholipids) compared to sham-exposed rats. Zucker rats displayed a normoglycemia associated with a high insulin level as opposed to Wistar rats which presented hyperglycemia and hypoinsulinemia after exposure to the SMF. During the glucose tolerance test, unexposed Zucker rats and Wistar rats exposed to the SMF exhibited a significantly higher hyperglycemia compared to sham-exposed Wistar rats suggesting an impairment of glucose clearance. In muscle, glycogen content was lower and phospholipids content was elevated for both unexposed Zucker rats and Wistar rats exposed to the SMF compared to Wistar rats sham control.
  
  
  CONCLUSIONS
  This study provides evidence that the metabolic alterations following exposure to a static magnetic field of moderate intensity could trigger the development of a pre-diabetic state.
authors.affiliation: Faculté des Sciences de Bizerte, Laboratoire de Physiologie Intégrée, Jarzouna, Tunisia.
authors.forename: Miryam
authors.initials: M
authors.lastname: Elferchichi
authors.forename: Jacques
authors.initials: J
authors.lastname: Mercier
authors.forename: Annick
authors.initials: A
authors.lastname: Bourret
authors.forename: René
authors.initials: R
authors.lastname: Gross
authors.forename: Anne-Dominique
authors.initials: AD
authors.lastname: Lajoix
authors.forename: Hatem
authors.initials: H
authors.lastname: Belguith
authors.forename: Hafedh
authors.initials: H
authors.lastname: Abdelmelek
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.forename: Karen
authors.initials: K
authors.lastname: Lambert
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control; D004574:Electromagnetic Fields; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000737:chemistry; D050356:Lipid Metabolism / Q000528:radiation effects; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D011924:Rats, Zucker; D013045:Species Specificity; D013696:Temperature
chemical_list: D006003:Glycogen; D005947:Glucose; D010100:Oxygen