title: A uterine leiomyoma in which a leiomyosarcoma with osteoclast-like giant cells and a metastasis of a ductal breast carcinoma are present.
abstract: Leiomyosarcoma of the uterus is a rare tumor, and the presence of osteoclast-like giant cells in this tumor is even rarer. A leiomyosarcoma arising in a leiomyoma is also quite unique. Breast cancer metastasizing to the uterus is seldom seen as well. A 70-year-old woman presented with metastasized breast cancer to the bones. An evaluation of the computed tomographic scan was made, which showed an enlarged uterus with a tumor. The tumor was a leiomyoma in which a leiomyosarcoma with osteoclast-like giant cells as well as a metastasis of a ductal breast carcinoma was present. To our knowledge, this is the first report of a leiomyosarcoma containing osteoclast-like giant cells, present in a leiomyoma, in a uterus also containing a ductal breast cancer metastasis present in the leiomyoma and myometrium.
authors.affiliation: Department of Pathology, Tergooiziekenhuizen, DA Hilversum, The Netherlands. hannah_vmeurs@yahoo.com
authors.forename: Hannah S
authors.initials: HS
authors.lastname: van Meurs
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Dieles
authors.forename: Herbert V
authors.initials: HV
authors.lastname: Stel
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000556:secondary*; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000175:diagnosis / Q000473:pathology*; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010010:Osteoclasts / Q000473:pathology; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary