title: Synthesis and self-assembly of a neoglycopeptide: morphological studies and ultrasound-mediated DNA encapsulation.
abstract: Self-assembly in peptides and proteins is an often encountered concept, where constituent building blocks are recruited and stabilized, via carefully orchestrated hydrophobic interactions, hydrogen bonding and other non-covalent interactions, to eventually reveal an array of supramolecular aggregates, with defined structural features. This study presents synthesis and self-assembly of a mannosylated peptide in aqueous medium. Turbidimetric assay with Concanavalin A (Con A), a mannose binding protein, was conducted to confirm the presence of hydrophilic mannose group on the exterior surface of self-assembled structures. DNA encapsulation in these soft structures was achieved by ultrasonication of soft spherical structures in the presence of plasmid DNA.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208 016 UP, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Gour
authors.forename: Sudipta
authors.initials: S
authors.lastname: Mondal
authors.forename: Sandeep
authors.initials: S
authors.lastname: Verma
mesh_terms: D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence
chemical_list: D006020:Glycopeptides