title: Identification of the minimal active sequence of an anti-influenza virus peptide.
abstract: The antiviral peptide, entry blocker (EB), inhibits influenza virus replication by preventing attachment to cells. Here, we identified the minimal and optimal EB sequence that retained antiviral activity with a 50% inhibitory concentration (IC(50)) and 50% effective concentration (EC(50)) similar to those of the full-length EB peptide and several truncated variants that possessed up to 10-fold lower IC(50)s. These data have implications for improving the antiviral efficacy of EB-derived peptides while decreasing production costs and easing synthesis.
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Jones
authors.forename: Erik W
authors.initials: EW
authors.lastname: Settles
authors.forename: Curtis R
authors.initials: CR
authors.lastname: Brandt
authors.forename: Stacey
authors.initials: S
authors.lastname: Schultz-Cherry
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D006801:Humans; D020128:Inhibitory Concentration 50; D008854:Microscopy, Electron; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000648:ultrastructure; D010455:Peptides / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D010455:Peptides