title: Correlation of major histocompatibility complex class I related A (MICA) polymorphism with the risk of developing breast cancer.
abstract: In the present study, we examined the association of different alleles of MICA gene with the risk of breast cancer development in Iranian population. Our data showed a significant relationship between longer alleles, alleles with 9- and 6-GCT repeat of MICA gene, and a higher risk of developing breast cancer according to the age of onset. The data indicated a 6-fold increase for developing breast cancer in patients carrying the allele with 6-GCT repeat after age 50 (OR = 5.8333, 95% CI: 1.2976-26/2236, P = 0.0172). In addition, patients carrying longer alleles in their genotype (6/6, 6/9, and 9/9 genotypes) were found significantly at higher risk of developing breast cancer than control individuals (OR = 5.6, P = 0.0038, 95% CI: 1.6578-18.9166). In contrast, alleles with short GCT repeat of 4 and 5.1 showed to play a role in reducing the risk of breast cancer (OR = 0.79, P = 0.3643 and 95% CI: 0.4743-1.3157). Women with allele 4 were found twofold more protected against breast cancer (OR = 0.4597, 95% CI: 0.2164-0.9765, P = 0.0401). The results suggested that women with genotypes with 9- and 6-GCT repeat alleles of MICA gene could be considered more potent to develop breast cancer especially at higher age.
authors.affiliation: Division of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran. svallian@biol.ui.ac.ir
authors.forename: Sadeq
authors.initials: S
authors.lastname: Vallian
authors.forename: Morteza Javadi
authors.initials: MJ
authors.lastname: Rad
authors.forename: Mahmood
authors.initials: M
authors.lastname: Tavallaei
authors.forename: Manoochehr
authors.initials: M
authors.lastname: Tavassoli
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007492:Iran; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A