title: [Aspergillus niger as a potential cellular factory: prior knowledge and key technology].
abstract: Aspergillus niger is an important industrial workhorse with extensive application in the sectors of industrial enzymes, heterogeneous proteins, organic acids and etc. The disclosure of its genomic sequence to the public brought the study of A. niger into the post-genomic era. Diverse omic data are being produced massively and rapidly, which largely upgrades our understanding to the hyperproduction mechanism of A. niger to a systems and molecular level. At meanwhile, its genetic operating system is becoming mature, which enables genome-scale genetic perturbation within A. niger. In conclusion, we are on the right way to redesign and engineer A. niger to an omnipotent cellular factory.
authors.affiliation: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Guo
authors.forename: Ping
authors.initials: P
authors.lastname: Zheng
authors.forename: Jibin
authors.initials: J
authors.lastname: Sun
mesh_terms: D001234:Aspergillus niger / Q000235:genetics* / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D016681:Genome, Fungal; D014176:Protein Biosynthesis / Q000235:genetics; D011994:Recombinant Proteins / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004798:Enzymes; D011994:Recombinant Proteins