title: Highly enantioselective synthesis of tetrahydroquinolines via cobalt(II)-catalyzed tandem 1,5-hydride transfer/cyclization.
abstract: A chiral catalyst prepared from N,N'-dioxide and Co(BF(4))(2)·6H(2)O was applied in the asymmetric hydride transfer initiated cyclization reaction, giving optically active tetrahydroquinolines in good yields with high enantioselectivities under mild reaction conditions. Meanwhile, in light of the absolute configuration of the product, a possible working model was proposed to explain the origin of the activation and asymmetric induction.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
authors.forename: Weidi
authors.initials: W
authors.lastname: Cao
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Wentao
authors.initials: W
authors.lastname: Wang
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011804:Quinolines; D003035:Cobalt; C542964:1,2,3,4-tetrahydroquinoline