title: [Relationship between GSK-3 beta -50T/C and DBI +529A/T polymorphisms in Japanese alcoholics].
abstract: As a help of the relationship between bipolar disorder and alcoholism, we studied the relationship between GSK-3 beta -50T/C polymorphism, which is reported to the relationship for bipolar disorder, and Japanese alcoholics. And we investigated the relationship between GSK-3 beta -50T/C polymorphism and DBI +529A/T polymorphisms, which is reported to one of the risk factor for alcoholism. We analyzed the GSK-3 beta genotype using a polymerase chain reaction (PCR), and DBI genotype using PCR with confronting two-pair novel primers (PCR-CTPP) in 75 health controls and 64 alcoholics. In this study, there was no significant difference in the frequency of GSK-3 beta -50T/C polymorphism between alcoholics and controls (p = 0.883), and there was no significant difference in the frequency of DBI +529A/T polymorphism (p = 0.131). Also, there was no relationship between GSK-3 beta -50T/C polymorphism and DBI +529A/T allele in alcoholism (p = 0.907). We suggested that bipolar disorder may not be one of the pathogenesis of alcoholism, and that there was no relationship between GSK-3 beta -50T/C polymorphism and DBI +529A/T polymorphism.
authors.affiliation: Laboratory of Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University, 1-17-71, Fuchinobe, Tyuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Kurihara
authors.forename: Jun
authors.initials: J
authors.lastname: Aoki
authors.forename: Maki
authors.initials: M
authors.lastname: Numajiri
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kawai
authors.forename: Chikako
authors.initials: C
authors.lastname: Waga
authors.forename: Eiji
authors.initials: E
authors.lastname: Yoshihara
authors.forename: Ohoshi
authors.initials: O
authors.lastname: Murayama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwahashi
mesh_terms: D057229:Alcoholics; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D044466:Asian People; D001714:Bipolar Disorder / Q000235:genetics; D026261:Diazepam Binding Inhibitor; D005260:Female; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D026261:Diazepam Binding Inhibitor; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3