title: Biodegradable elastomers for tissue engineering and cell-biomaterial interactions.
abstract: Synthetic biomaterials serve as a cornerstone in the development of clinically focused regenerative medicine therapies that aim to reduce suffering and prolong life. Recent improvements in biodegradable elastomeric materials utilize natural extracellular matrix proteins as inspiration to yield a new class of materials with superior degradation kinetics, desirable biocompatibility profiles, and mechanical properties that closely match those of soft tissues. This review describes several classes of synthetic biodegradable elastomers and associated fabrication techniques that are relevant to scaffold development. The application of these materials to select tissue engineering models is also discussed.
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, Pennsylvania 15232, USA. cbetting@andrew.cmu.edu
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bettinger
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000145:classification; D020724:Elastomers / Q000737:chemistry* / Q000145:classification; D016326:Extracellular Matrix Proteins / Q000737:chemistry*; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D016326:Extracellular Matrix Proteins