title: Novel F-18-labeled PET myocardial perfusion tracers: bench to bedside.
abstract: Myocardial perfusion imaging is a widely used approach to noninvasively identify myocardial ischemia and guide therapies. It is typically performed using single photon emission computed tomography. The competing technology positron emission tomography (PET) offers higher diagnostic accuracies but suffers from logistical limitations due to the use of short-lived radioisotopes. New (18)F-labeled perfusion markers were introduced in the past years and offer simplified supply approaches, as known from oncologic PET imaging. This review summarizes the available literature especially from preclinical studies, but also very recent findings from early clinical trials. We discuss the consequences of long-lived radioisotopes in myocardial PET and the potential role of absolute blood flow quantification to establish efficient clinical protocols.
authors.affiliation: Nuklearmedizinische Klinik und Poliklinik der Technischen, Universität München, Germany. stephan.nekolla@tum.de
authors.forename: Stephan G
authors.initials: SG
authors.lastname: Nekolla
authors.forename: Antti
authors.initials: A
authors.lastname: Saraste
mesh_terms: D054316:Biomarkers, Pharmacological; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005080:Exercise Test; D019788:Fluorodeoxyglucose F18; D006439:Hemodynamics; D006801:Humans; D023421:Models, Animal; D015425:Myocardial Reperfusion / Q000295:instrumentation / Q000379:methods*; D009206:Myocardium / Q000473:pathology*; D049268:Positron-Emission Tomography; D011877:Radionuclide Imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D054316:Biomarkers, Pharmacological; D019788:Fluorodeoxyglucose F18