title: I-123 MIBG scintigraphy and 68Ga-DOTANOC PET/CT negative but F-18 DOPA PET/CT positive pheochromocytoma: a case report.
abstract: We observed a 34-year-old man who was incidentally found to have an adrenal mass during surgical follow-up for perforated ulcer. The patient was subjected to I-123 MIBG scintigraphy, 68Ga-DOTANOC PET/CT, and F-18 DOPA PET/CT. Only F-18 DOPA PET/CT showed evidence of an avid adrenal mass. A CT-guided biopsy was performed and it was suggestive for pheochromocytoma. He underwent surgery and a pheochromocytoma, about 40 mm in diameter, was detected. Traditionally, I-123 MIBG scintigraphy has been used in detecting chromaffin cell tumors, but more recently it had been demonstrated that a certain part of pheochromocytoma could be false-negative on scintigraphy.
authors.affiliation: Unità Operativa di Medicina Nucleare, Policlinico S. Orsola-Malpighi, Bologna, Italy. ilary.grassi@libero.it
authors.forename: Ilaria
authors.initials: I
authors.lastname: Grassi
authors.forename: Cristina
authors.initials: C
authors.lastname: Nanni
authors.forename: Valentina
authors.initials: V
authors.lastname: Vicennati
authors.forename: Paolo
authors.initials: P
authors.lastname: Castellucci
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Allegri
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Montini
authors.forename: Uberto
authors.initials: U
authors.lastname: Pagotto
authors.forename: Guido
authors.initials: G
authors.lastname: di Dalmazi
authors.forename: Renato
authors.initials: R
authors.lastname: Pasquali
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
mesh_terms: D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D000328:Adult; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005188:False Negative Reactions; D006801:Humans; D008297:Male; D009942:Organometallic Compounds; D010673:Pheochromocytoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; C043437:fluorodopa F 18; D019797:3-Iodobenzylguanidine; D004295:Dihydroxyphenylalanine