title: Abdominal mesotherapy injection extended the absorption of follicle-stimulating hormone.
abstract: Abdominal mesotherapy injection of recombinant human FSH (rhFSH) was well tolerated with increased net absorption (AUC0-∞ 4,655.3 IU·h/L and t1/2 247.6 h) up to 360 hours compared with those of 120 hours (AUC0-∞ 1,915.7 IU·h/L and t1/2 101.8 h). The extended absorption of rhFSH suggests that abdominal mesotherapy injection mode be considered for future administration of rhFSH in controlled ovarian hyperstimulation.
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan. tube2363808@gmail.com
authors.forename: Chao-Chin
authors.initials: CC
authors.lastname: Hsu
authors.forename: Hsin-Chih
authors.initials: HC
authors.lastname: Kuo
authors.forename: Chao-Tien
authors.initials: CT
authors.lastname: Hsu
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
mesh_terms: D034841:Abdominal Cavity; D000327:Adsorption; D000328:Adult; D019540:Area Under Curve; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists; D006801:Humans; D007267:Injections; D057748:Mesotherapy / Q000379:methods*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D013997:Time Factors; D055815:Young Adult
chemical_list: D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone