title: Improvement of cutaneous sensitivity in diabetic peripheral neuropathy with combination L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate.
abstract: Studies of monotherapy with L-methylfolate, methylcobalamin, or pyridoxal 5'-phosphate suggest that these B vitamins may reverse both the symptoms and the pathophysiology of diabetic peripheral neuropathy (DPN). The efficacy of oral-combination L-methylfolate, 3 mg; methylcobalamin, 2 mg; and pyridoxal 5'-phosphate, 35 mg (LMF-MC-PP) in restoring cutaneous sensitivity in patients with type 2 diabetes with DPN was evaluated in 20 type 2 diabetic patients who were given LMF-MC-PP twice daily for 4 weeks and then once daily for an additional 48 weeks. Statistically significant improvement in 1-point (tactile) and 2-point (discriminatory) static testing at the right and left great toe and heel in the patients was observed in all 3 follow-up periods: 1) baseline to 6 months, 2) baseline to 1 year, and 3) 6 months to 1 year. The greatest improvement occurred between baseline and 1 year of treatment. Treatment with oral LMF-MC-PP appears to promote restoration of lost cutaneous sensation in DPN.
authors.affiliation: Carolina Musculoskeletal Institute, Aiken, SC, USA.
authors.forename: Mackie J
authors.initials: MJ
authors.lastname: Walker
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Morris
authors.forename: Dunlei
authors.initials: D
authors.lastname: Cheng
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D010865:Pilot Projects; D011732:Pyridoxal Phosphate / Q000008:administration & dosage*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D013763:Tetrahydrofolates / Q000008:administration & dosage*; D014110:Touch / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D013763:Tetrahydrofolates; D011732:Pyridoxal Phosphate; C019476:mecobalamin; D014805:Vitamin B 12; C005984:5-methyltetrahydrofolate