title: Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production.
abstract: Dehydration of fructose and glucose in dipolar, aprotic solvents leads to formation of 5-hydroxymethylfurfural. Conditions for continuous flow reactions using a cartridge-based reactor system and a stop-flow microwave reactor were established showing very good product yields and selectivity without the limitation of a batch process such as upscaling and precise temperature monitoring and control. A maximum product HPLC yield of 90.3% under cartridge-based heating and 85.6% under microwave heating could be achieved using mild and quick reaction conditions. Formation of levulinic acid as a by-product could not be detected under the optimized reaction conditions.
authors.affiliation: Institute for Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163, 1060 Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Schön
authors.forename: Michael
authors.initials: M
authors.lastname: Schnürch
authors.forename: Marko D
authors.initials: MD
authors.lastname: Mihovilovic
mesh_terms: D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003890:Desiccation; D005632:Fructose / Q000737:chemistry; D005662:Furaldehyde / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D005947:Glucose / Q000737:chemistry
chemical_list: D005632:Fructose; C008046:5-hydroxymethylfurfural; D005662:Furaldehyde; D005947:Glucose