title: In vitro evaluation of ketoprofen controlled release from various formulations.
abstract: The aim of this study is to investigate the potential utility of some hydrogels, based on chitosan, chitosan modified with phthalic anhydride and 75/25 poly(N-isopropyl acrylamide)/alginate, for preparing drug release systems containing ketoprofen, as model drug.
  
  
  METHODS
  The in vitro release profiles and swelling studies were done in ethanol medium, where the studied drug presents high solubility, at 25 degrees C (room temperature). The ketoprofen release was observed by monitoring the absorbance at max = 254 nm as a function of time.
  
  
  RESULTS
  The experimental results indicated that the smallest amount of drug was released from chitosan matrices, appreciatively 31%.
  
  
  CONCLUSIONS
  The composition of hydrogels had an important effect on ketoprofen release.
authors.affiliation: Physical Chemistry of Polymers Department, P. Poni Institute of Macromolecular Chemistry laşi.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Oprea
authors.forename: Raluca Petronela
authors.initials: RP
authors.lastname: Dumitriu
authors.forename: Cătălina
authors.initials: C
authors.lastname: Cheaburu
authors.forename: Cornelia
authors.initials: C
authors.lastname: Vasile
mesh_terms: D000464:Alginates / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D001672:Biocompatible Materials / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D010796:Phthalic Anhydrides / Q000737:chemistry; D012995:Solubility; D013696:Temperature
chemical_list: D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020100:Hydrogels; D010796:Phthalic Anhydrides; D000431:Ethanol; D020723:Glucuronic Acid; D048271:Chitosan; D007660:Ketoprofen; C043103:phthalic anhydride