title: Roles and mechanisms of microRNAs in pancreatic cancer.
abstract: Pancreatic cancer (PC) is an aggressive malignancy with poor survival. The discovery of microRNAs (miRNAs) has provided a new opportunity to study the disease. Thus far, altered expression of miRNAs has been reported in a wide range of malignancies, including PC, and some miRNAs are associated with PC cell proliferation, invasion, chemoresistance, and patient survival. This review summarizes recent advances with respect to the roles and mechanisms of miRNAs in PC and discusses potential clinical applications.
authors.affiliation: Michael E. DeBakey Department of Surgery, Molecular Surgeon Research Center, Baylor College of Medicine, One Baylor Plaza, Mail stop BCM391, Houston, TX, 77030, USA.
authors.forename: Lidong
authors.initials: L
authors.lastname: Zhang
authors.forename: Md Saha
authors.initials: MS
authors.lastname: Jamaluddin
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Weakley
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Yao
authors.forename: Changyi
authors.initials: C
authors.lastname: Chen
mesh_terms: D049109:Cell Proliferation; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D015996:Survival Rate
chemical_list: D035683:MicroRNAs