title: Schistosoma haematobium infection affects Plasmodium falciparum-specific IgG responses associated with protection against malaria.
abstract: We have previously shown that antibody responses directed to Plasmodium falciparum merozoite surface protein (MSP)-1, MSP-2 and glutamate-rich protein (GLURP) are associated with anti-malarial protection in residents of the Niakhar area of Senegal. In the same area, urinary schistosomiasis is frequent and we therefore assessed the possible influence of Schistosoma haematobium infection on these protective anti-malarial IgG responses. After adjustment for confounders, we found that the levels of IgG1 directed to MSP1 and GLURP were significantly lower in helminth carriers. The higher circulating levels of interleukin (IL)-10 present in the plasma of co-infected individuals were associated with decreased anti-plasmodial IgG responses, particularly of those directed to MSP-2. Our data thus reveal a modulation of P. falciparum-specific immune responses in the presence of a trematode helminth infection, potentially increasing infected individuals' risk of plasmodial infection or disease.
authors.affiliation: Institut de Recherche pour le Développement (IRD), Unité Mixte de Recherche (UMR) 216 «Mère et enfant face aux infections tropicales», Laboratoire de Parasitologie, Université Paris Descartes, Paris, France. David.Courtin@ird.fr
authors.forename: D
authors.initials: D
authors.lastname: Courtin
authors.forename: A
authors.initials: A
authors.lastname: Djilali-Saïah
authors.forename: J
authors.initials: J
authors.lastname: Milet
authors.forename: V
authors.initials: V
authors.lastname: Soulard
authors.forename: O
authors.initials: O
authors.lastname: Gaye
authors.forename: F
authors.initials: F
authors.lastname: Migot-Nabias
authors.forename: R
authors.initials: R
authors.lastname: Sauerwein
authors.forename: A
authors.initials: A
authors.lastname: Garcia
authors.forename: A J F
authors.initials: AJ
authors.lastname: Luty
mesh_terms: D000293:Adolescent; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D020066:Merozoite Surface Protein 1 / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology; D012548:Schistosoma haematobium / Q000276:immunology*; D012553:Schistosomiasis haematobia / Q000276:immunology*; D012675:Senegal; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007074:Immunoglobulin G; D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C072492:glutamate-rich protein, Plasmodium