title: No observable relationship between the 12 genes of nervous system and reasoning skill in a young Chinese Han population.
abstract: Reasoning skill is an advanced cognitive ability which is needed for drawing inferences from given information. It is well known that the ability depends on the neural network of the frontal and parietal brain regions. In this study, we hypothesized that some genes involved in neurotransmitter systems were related to reasoning skill. To confirm this hypothesis, we examined the effects of 13 genes (BDNF, NRSF, COMT, DBH, DRD(2), DRD(3), DAT(1), MAOA, GRM(1), GRIN2B, TPH(2), 5-HT(2A), and 5-HT(6)) in neurotransmitter systems on the non-verbal reasoning and verbal reasoning skills. The results indicated there were on significant effects of the 17 functional variants of these genes on the performance of non-verbal reasoning and verbal analogical reasoning skills (χ(2) > 3.84, df = 1, P > 0.05). This study suggests that some of the functional variations in BDNF, COMT, DBH, DRD(2), DRD(3), MAOA, 5-HT(2A), 5-HT(6), GRM(1), and GRIN2B have no observable effects on the certain reasoning skills in a young healthy Chinese Han population.
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Xi'an, 710069, China.
authors.forename: Pingyuan
authors.initials: P
authors.lastname: Gong
authors.forename: Fuchang
authors.initials: F
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Lei
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Chen
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Zhang
authors.forename: Kejin
authors.initials: K
authors.lastname: Zhang
authors.forename: Anyun
authors.initials: A
authors.lastname: Zheng
authors.forename: Xiaocai
authors.initials: X
authors.lastname: Gao
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D003142:Communication; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005796:Genes; D005838:Genotype; D006801:Humans; D008297:Male; D009420:Nervous System / Q000378:metabolism*; D011340:Problem Solving; D055815:Young Adult