title: Comparison of C-reactive protein levels in pregnancies with retained and removed intrauterine device.
abstract: OBJECTIVE
  We aimed to investigate possible alterations in circulating levels of the high sensitivity (hs)-C-reactive protein (CRP) reflecting tissue inflammation in patients who conceived with an intrauterine device (IUD) and in pregnancies after IUD removal in early pregnancy.
  
  
  METHODS
  Serum hs-CRP levels were measured in 30 pregnant women with retained IUD and 18 pregnancies after IUD removal in early pregnancy. Rates of total miscarriage, premature rupture of membranes (PROMs), low birth weight, placental abruption, and preterm delivery were also documented.
  
  
  RESULTS
  Serum levels of CRP were significantly higher in pregnant women with retained IUD than pregnancies with removed IUD. Total miscarriage, PROMs, placental abruption, and preterm delivery rates were significantly higher in pregnant women with retained IUD compared with pregnancies after IUD removal in early pregnancy.
  
  
  CONCLUSIONS
  Serum CRP concentrations are increased in pregnant women with retained IUD. Our findings also suggest that the pregnancies with retained IUDs that are not removed are at increased risk for adverse pregnancy outcomes.
authors.affiliation: Obstetrics Department, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. deveer3@hotmail.com
authors.forename: Rüya
authors.initials: R
authors.lastname: Deveer
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustun
authors.forename: Esma
authors.initials: E
authors.lastname: Sarikaya
authors.forename: Pinar
authors.initials: P
authors.lastname: Aydogan
authors.forename: Melike
authors.initials: M
authors.lastname: Doğanay
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoğlu
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D020878:Device Removal / Q000009:adverse effects / Q000706:statistics & numerical data*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000209:etiology; D058736:Intrauterine Device Migration / Q000009:adverse effects; D007434:Intrauterine Devices; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D011256:Pregnancy Outcome / Q000453:epidemiology; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein