title: Prolyl hydroxylase and hypoxia inducible factor: potential targets for cancer therapy.
abstract: Prolyl hydroxylase (PHD) is one of the major enzymes that play a key role in metastasis and angiogenesis. PHD regulates tumor progression by the degradation of hypoxia inducible factor-α (HIF-α), an important factor associated with angiogenesis. This review will provide an overview of the role of PHD and HIF in tumor progression and how it can serve as potential targets for cancer therapy.
authors.affiliation: Department of Biotechnology, Karunya University, Karunya Nagar, Coimbatore, Tamil Nadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Prabhu
authors.forename: C
authors.initials: C
authors.lastname: Guruvayoorappan
mesh_terms: D000818:Animals; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D011393:Procollagen-Proline Dioxygenase