title: Effect of selenium-containing products on antioxidant enzyme activity in the kidneys, liver, and blood of guinea pigs.
abstract: The antioxidant system of some tissues in guinea pigs with no selenium deficiency was studied after treatment with selenium-containing products. Activity of a selenium-containing enzyme glutathione peroxidase was significantly reduced in the kidneys and blood. The kidneys were characterized by low activity of glutathione reductase and high activity of SOD. These features illustrate the development of oxidative stress in the kidneys.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. sirotatv@rambler.ru
authors.forename: T V
authors.initials: TV
authors.lastname: Sirota
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D017646:Organosilicon Compounds / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D064586:Selenic Acid; D018036:Selenium Compounds / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017646:Organosilicon Compounds; D018036:Selenium Compounds; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; D064586:Selenic Acid