title: The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade.
abstract: Cancer metastasis results from a multi-step cascading process that includes: 1) vascularization of the primary tumor; 2) detachment and invasion of cancer cells; 3) intravasation into lymphatic and blood vessels; 4) survival and arrest in the circulation; 5) extravasation into distant organs; and 6) colonization and growth of metastatic tumors. microRNAs (miRNAs) play critical roles in this multi-step process, both promoting and suppressing metastasis. This review updates the progress made in understanding the roles of miRNAs for invasion and metastasis during cancer progression. A specific miRNA signature of cancer metastasis is also reviewed.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Le
authors.forename: Omar
authors.initials: O
authors.lastname: Merchant
authors.forename: Robert C
authors.initials: RC
authors.lastname: Bast
authors.forename: George A
authors.initials: GA
authors.lastname: Calin