title: Combinatorial synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives catalyzed by iodine in ionic liquids.
abstract: A combinatorial synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives is described by a reaction of 2-aminobenzohydrazides with two equivalents of aldehydes or ketones in ionic liquids catalyzed by iodine. Controlling the reaction temperature or reducing the activity of the substrates, respectively, the intermediate products of hydrazones were obtained first, and then they were applied to react with various aromatic aldehydes without being separated, resulting in structural diversification of quinazolinone derivatives.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, The Key Laboratory of Biotechnology on Medical Plant, Xuzhou Jiangsu, P. R. China. xswang1974@yahoo.com
authors.forename: Xiang-Shan
authors.initials: XS
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Sheng
authors.forename: Lian
authors.initials: L
authors.lastname: Lu
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Li
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007455:Iodine / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000588:Amines; D052578:Ionic Liquids; D052999:Quinazolinones; D007455:Iodine