title: Neurological involvement in paediatric Behçet's disease.
abstract: BACKGROUND
  Behçet disease (BD) is a systemic vasculitis which can affect the neurological system. Neuro-Behçet's disease (NBD) is not well described in children.
  
  
  OBJECTIVE
  Our study aimed to analyse the clinical patterns of paediatric NBD and to describe their repercussions on children's schooling.
  
  
  METHODS
  We performed a retrospective chart review of 12 NBD children and a phone interview of patients and their physicians to investigate their last physical and schooling status.
  
  
  RESULTS
  In 40 BD patients reviewed, 12 (sex ratio 8M/4F) had neurological involvement. The mean age of onset was 11 years. In 4 cases, neurological symptoms were the initial presentation. In other cases, NBD occurred within a mean time of 10 months after BD was diagnosed. Cerebral venous thromboses were frequent (5/12) as compared to recurrent meningoencephalitis (2/12), rhombencephalitis (2/12), transverse myelitis (1/12), peripheral neuropathy (1/12) or psychiatric disturbances (1/12). 9 patients had sequelae and 8 had difficulties in learning. 6 stopped at middle school level. For the other patients, an arrangement of the teaching environment was needed due to visual, auditory and concentration disorders.
  
  
  CONCLUSIONS
  Neurological involvement is frequent in BD children and its consequences could be severe. Timely accommodations are required to facilitate their ability to follow the normal curriculum.
authors.affiliation: Department of Paediatric Neurology, Bicêtre University Hospital, Le Kremlin Bicêtre, France.
authors.forename: J
authors.initials: J
authors.lastname: Metreau-Vastel
authors.forename: Y
authors.initials: Y
authors.lastname: Mikaeloff
authors.forename: M
authors.initials: M
authors.lastname: Tardieu
authors.forename: I
authors.initials: I
authors.lastname: Koné-Paut
authors.forename: T-A
authors.initials: TA
authors.lastname: Tran
mesh_terms: D000293:Adolescent; D001284:Atrophy; D001528:Behcet Syndrome / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D004522:Educational Status; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D007858:Learning; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D012574:Schools; D020246:Venous Thrombosis / Q000473:pathology / Q000503:physiopathology