title: Comparison of electrocardiographic recordings in open-chest and closed-chest swine models.
abstract: The aim of our study was to compare the electrocardiographic recordings in an experimental open-chest swine model before and after left-sided thoracotomy to detect any surgery-induced fluctuations that might interfere with subsequent experimental interventions. We obtained electrocardiograms from 8 deeply anesthetized domestic swine and compared the respective ST-segment potentials obtained after vascular surgery and after left-sided thoracotomy and dissection of the left anterior descending coronary artery. Compared with baseline recordings, no significant ST-segment deviation on any of the electrocardiographic leads occurred after vascular surgery. However, statistically significant ST-segment depression was observed after thoracotomy. Invasive surgical procedures in open-chest swine models may lead to morphologic changes in the ST segment. The physiologic mechanism of these changes is not fully understood.
authors.affiliation: Research Center, Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Sherif
authors.initials: S
authors.lastname: Shousha
authors.forename: Jean G
authors.initials: JG
authors.lastname: Diodati
authors.forename: Marilyn
authors.initials: M
authors.lastname: de Chantal
authors.forename: Thierry
authors.initials: T
authors.lastname: Charron
authors.forename: Robert
authors.initials: R
authors.lastname: Amyot
authors.forename: Erick
authors.initials: E
authors.lastname: Schampaert
authors.forename: Chantal
authors.initials: C
authors.lastname: Pharand
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000601:surgery; D004562:Electrocardiography / Q000295:instrumentation / Q000662:veterinary*; D006339:Heart Rate; D008297:Male; D023421:Models, Animal; D013522:Surgery, Veterinary / Q000379:methods*; D034421:Sus scrofa / Q000601:surgery*; D013908:Thoracotomy / Q000009:adverse effects / Q000662:veterinary*; D014656:Vascular Surgical Procedures / Q000009:adverse effects