title: HIV genetic diversity between plasma and cerebrospinal fluid in patients with HIV encephalitis.
abstract: In patients with HIV encephalitis, a low viral diversity between the plasma and cerebrospinal fluid (CSF) HIV-1 viruses was associated with detectable HIV RNA in plasma and a higher level of central nervous system penetration effectiveness (CPE) score, taking into account the genotypic susceptibility score of the current treatment (named balanced score). This result suggests that the CSF viruses were probably originating from the plasma. Conversely, a high viral genetic diversity was associated with an undetectable HIV RNA in plasma and low-balanced CPE, which is in favour of an autonomous replication in the central nervous system.
authors.affiliation: Université Pierre et Marie Curie-Paris 6, UMR S-943, France. cathia.soulie@psl.aphp.fr
authors.forename: Cathia
authors.initials: C
authors.lastname: Soulié
authors.forename: Slim
authors.initials: S
authors.lastname: Fourati
authors.forename: Sidonie
authors.initials: S
authors.lastname: Lambert-Niclot
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Ana
authors.initials: A
authors.lastname: Canestri
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Laurence
authors.initials: L
authors.lastname: Morand-Joubert
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D004660:Encephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics* / Q000821:virology; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid / Q000235:genetics*; D019562:Viral Load; D014779:Virus Replication / Q000235:genetics*
chemical_list: D012367:RNA, Viral