title: Histone acetyltransferases as regulators of nonhistone proteins: the role of interferon regulatory factor acetylation on gene transcription.
abstract: When studying transcription factors, it is necessary to investigate posttranslational modifications. Histone acetyltransferases (HATs) are typical of the modification enzymes involved in chromatin regulation. HATs acetylate the transcription factors (nonhistone proteins) as well as histones. Interferon regulatory factors (IRFs) are transcription factors that bind to the interferon regulatory element (IRF-E) and are involved in regulating cell growth, differentiation, and the immune and hematopoietic systems. During the process of binding to a specific DNA element, IRFs also bind to coactivators such as HATs and become modified. This review looks at how IRFs associate with HATs, p300, and PCAF, and thereby contribute to transcriptional activation.
authors.affiliation: Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Gakuen, 4-7-1 Musashimurayama-shi, Tokyo 208-0011, Japan. amasumi@nih.go.jp
authors.forename: Atsuko
authors.initials: A
authors.lastname: Masumi
mesh_terms: D000107:Acetylation; D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000378:metabolism*; D011485:Protein Binding; D014158:Transcription, Genetic
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D050835:Interferon Regulatory Factors; D051548:Histone Acetyltransferases