title: Copy number variation and susceptibility to complex traits.
abstract: Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human diseaserelevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci.
authors.affiliation: John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
authors.forename: Cesar P
authors.initials: CP
authors.lastname: Canales
authors.forename: Katherina
authors.initials: K
authors.lastname: Walz
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D018628:Gene Dosage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D051379:Mice; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: C109561:CDRT1 protein, human; D004268:DNA-Binding Proteins; C116115:MYCBP protein, human; D009185:Myelin Proteins; C073687:PMP22 protein, human; D011506:Proteins; D014157:Transcription Factors