title: The role of BRCA1 in DNA damage response.
abstract: BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.
authors.affiliation: Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Jiaxue
authors.initials: J
authors.lastname: Wu
authors.forename: Lin-Yu
authors.initials: LY
authors.lastname: Lu
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Yu
mesh_terms: D017209:Apoptosis / Q000235:genetics; D019313:BRCA1 Protein / Q000235:genetics / Q000502:physiology*; D001943:Breast Neoplasms / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D019313:BRCA1 Protein