title: Replacing white rice with pre-germinated brown rice mildly ameliorates hyperglycemia and imbalance of adipocytokine levels in type 2 diabetes model rats.
abstract: Pre-germinated brown rice (PR) has been developed industrially in order to enhance the nutritional functions of its source material, brown rice (BR). The present study was aimed at clarifying the effect of PR on the type 2 diabetes mellitus. We employed Otsuka Long-Evans Tokushima Fatty (OLETF) rats as a model of type-2 diabetes mellitus. OLETF rats were fed on either PR or white rice (WR) from the age of 4 to 35 wk. Age-matched male Long-Evans Tokushima Otsuka (LETO) rats as a non-diabetic control were also fed on WR. The HbA(1c) level in OLETF rats was significantly higher than that in LETO rats. However, the level was lower in PR-fed OLETF rats than in WR-fed OLETF rats. The plasma concentrations of TNF-α and PAI-1 in OLETF rats were higher than those in LETO rats. However, both elevated levels were decreased by the PR-feeding, but not by the WR-feeding. On the other hand, the plasma adiponectin concentration in OLETF rats was lower than that in LETO rats. The decrease in adiponectin level of OLETF rats was ameliorated by PR-feeding. The size of adipocytes in PR-fed OLETF rats was smaller than that in WR-fed OLETF rats. In summary, intake of PR instead of WR ameliorates both insulin resistance and imbalance of the levels of plasma adipocytokines leading to diabetic complications.
authors.affiliation: Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences, Fujisawa, Kanagawa, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Torimitsu
authors.forename: Ryouhei
authors.initials: R
authors.lastname: Nagase
authors.forename: Megumi
authors.initials: M
authors.lastname: Yanagi
authors.forename: Miyuki
authors.initials: M
authors.lastname: Homma
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Sasai
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Ito
authors.forename: Kousuke
authors.initials: K
authors.lastname: Hayamizu
authors.forename: Shouta
authors.initials: S
authors.lastname: Nonaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Hosono
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kise
authors.forename: Taiichiro
authors.initials: T
authors.lastname: Seki
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Ariga
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D054392:Adipokines / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D004032:Diet; D004195:Disease Models, Animal; D006943:Hyperglycemia / Q000178:diet therapy*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D012275:Oryza / Q000378:metabolism*; D051381:Rats; D020334:Rats, Inbred OLETF; D020318:Rats, Long-Evans
chemical_list: D054392:Adipokines; D001786:Blood Glucose; D007328:Insulin