title: Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses.
abstract: BACKGROUND
  the search for effective inhibitors to multiple infectious agents including influenza, smallpox and hemorrhagic fever viruses is an area of active research as many of these agents pose dramatic health and economic challenges to the human population. Many of these infectious agents are not only endemic threats in different parts of the globe, but are also considered to have the potential of being used as bioterrorism agents.
  
  
  METHODS
  this review focuses on inhibitors that are currently in use in the research community against specific emerging infectious agents and those that have bioterrorism potential. The paper provides information about the availability of FDA approved drugs, whenever applicable, and insights into the specific aspect of the agent life cycle that is affected by drug treatment, when known.
  
  
  CONCLUSIONS
  the key message that is conveyed in this review is that a combination of pathogen and host-based inhibitors may have to be used for successful control of viral replication to limit the development of drug resistance.
authors.affiliation: George Mason University, National Center for Biodefense and Infectious Diseases, Discovery Hall, Room 306, 10900 University Blvd. MS 1H8, Manassas, VA 20110, USA.
authors.forename: Aarthi
authors.initials: A
authors.lastname: Narayanan
authors.forename: Charles
authors.initials: C
authors.lastname: Bailey
authors.forename: Fatah
authors.initials: F
authors.lastname: Kashanchi
authors.forename: Kylene
authors.initials: K
authors.lastname: Kehn-Hall
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D018050:Arenavirus / Q000187:drug effects; D023482:Bioterrorism; D002043:Bunyaviridae / Q000187:drug effects; D024882:Drug Resistance, Viral; D016563:Filoviridae / Q000187:drug effects; D006482:Hemorrhagic Fevers, Viral / Q000188:drug therapy*; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000188:drug therapy*; D012899:Smallpox / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D007252:Influenza Vaccines