title: Safe application of mitomycin C within the nasal cavity.
abstract: OBJECTIVE
  To describe a novel technique of delivering mitomycin C safely via endoscopic sinus surgery.
  
  
  METHODS
  Mitomycin C was applied in the median frontal drainage pathway of a 44-year-old woman suffering from recalcitrant chronic frontal sinusitis. The mitomycin C was soaked onto a neurosurgical patty, which was delivered through a nasopharyngeal tube trimmed to ensure delivery directly to the desired area, thus sparing adjacent mucosa.
  
  
  CONCLUSIONS
  Mitomycin C has been suggested to have a useful role in reducing post-operative scarring after endonasal surgery. The long term safety of topical mitomycin C is not yet known, and inadvertent topical application to adjacent mucosa should be avoided. The described technique achieves this in a simple manner, and can be easily applied to other locations.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK. tatianagutierrez@doctors.org.uk
authors.forename: T
authors.initials: T
authors.lastname: Gutierrez
authors.forename: C
authors.initials: C
authors.lastname: Hopkins
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D002908:Chronic Disease; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D016503:Drug Delivery Systems; D004724:Endoscopy / Q000009:adverse effects; D005260:Female; D015522:Frontal Sinusitis / Q000601:surgery*; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage* / Q000494:pharmacology; D009296:Nasal Cavity; D012008:Recurrence
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin