title: Histologic and immunohistologic characterization of skin localization of myeloid disorders: a study of 173 cases.
abstract: A retrospective analysis of 173 skin biopsy specimens of myeloid leukemia cutis (MLC) was performed to determine histologic and immunophenotypic criteria that could distinguish the varied myeloid disorders from one another. For the study, 11 relevant histologic items were scored and 12 antigens were studied (CD68 [KP1], CD163, CD14, CD4, myeloperoxidase [MPO], CD33, CD117, CD34, CD56, MIB-1, CD303, and CD123). Underlying myeloid disorders were essentially acute myeloid leukemias (65.3%), chronic myelomonocytic leukemias (11.0%), and refractory anemia (10.4%). Skin lesions were de novo in 7.5%, concurrent in 26.6%, and subsequent in 60.7%. Several morphologic characteristics (density, size of tumor cells, inflammatory background) were statistically useful in distinguishing between varied myeloid disorders. De novo MLCs displayed a specific morphologic profile. Association of CD68, CD33, and MPO could diagnose 100% of the cases of MLC. However, the immunohistochemical panel could not distinguish between the varied underlying myeloid disorders, with the exception that CD123 was particularly powerful in recognizing chronic myelomonocytic leukemia and also permitted reclassification of 4 cases as blastic plasmacytoid dendritic cell neoplasm.
authors.affiliation: University Hospital Center, Plateau Biology Technology Gerard Mack, Dijon, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bénet
authors.forename: Aurélie
authors.initials: A
authors.lastname: Gomez
authors.forename: Claire
authors.initials: C
authors.lastname: Aguilar
authors.forename: Claire
authors.initials: C
authors.lastname: Delattre
authors.forename: Béatrice
authors.initials: B
authors.lastname: Vergier
authors.forename: Marie
authors.initials: M
authors.lastname: Beylot-Barry
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fraitag
authors.forename: Agnès
authors.initials: A
authors.lastname: Carlotti
authors.forename: Pierre
authors.initials: P
authors.lastname: Dechelotte
authors.forename: Valérie
authors.initials: V
authors.lastname: Hospital
authors.forename: Michel
authors.initials: M
authors.lastname: d'Incan
authors.forename: Valérie
authors.initials: V
authors.lastname: Costes
authors.forename: Olivier
authors.initials: O
authors.lastname: Dereure
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ortonne
authors.forename: Martine
authors.initials: M
authors.lastname: Bagot
authors.forename: Liliane
authors.initials: L
authors.lastname: Laroche
authors.forename: Astrid
authors.initials: A
authors.lastname: Blom
authors.forename: Sophie
authors.initials: S
authors.lastname: Dalac
authors.forename: Tony
authors.initials: T
authors.lastname: Petrella
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000473:pathology; D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000151:congenital / Q000473:pathology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000032:analysis; D012189:Retrospective Studies; D063268:Sialic Acid Binding Ig-like Lectin 3; D012878:Skin Neoplasms / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D009195:Peroxidase; D063268:Sialic Acid Binding Ig-like Lectin 3; C571163:CD33 protein, human; C067980:CD68 antigen, human; D000097382:CD68 Molecule