title: Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice.
abstract: The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues. We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice. We show that intra-ACC opioid receptor blockade disrupted expression of an ethanol-induced conditioned place preference, suggesting that endogenous opioid modulation in the ACC may be critical for maintaining the cue's conditioned rewarding effects.
authors.affiliation: Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239-3098, USA. gremelc@mail.nih.gov
authors.forename: Christina M
authors.initials: CM
authors.lastname: Gremel
authors.forename: Emily A
authors.initials: EA
authors.lastname: Young
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Cunningham
mesh_terms: D000428:Alcohol Drinking / Q000523:psychology*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D003463:Cues; D000431:Ethanol / Q000494:pharmacology; D006179:Gyrus Cinguli / Q000187:drug effects*; D008297:Male; D000077239:Meloxicam; D051379:Mice; D008811:Mice, Inbred DBA; D009270:Naloxone / Q000031:analogs & derivatives / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013843:Thiazines / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D017557:Ventral Tegmental Area / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002492:Central Nervous System Depressants; D009292:Narcotic Antagonists; D000644:Quaternary Ammonium Compounds; D013843:Thiazines; D013844:Thiazoles; D009270:Naloxone; D000431:Ethanol; C041269:N-methylnaloxone; D000077239:Meloxicam