title: QT Measurement and Heart Rate Correction during Hypoglycemia: Is There a Bias?
abstract: Introduction. Several studies show that hypoglycemia causes QT interval prolongation. The aim of this study was to investigate the effect of QT measurement methodology, heart rate correction, and insulin types during hypoglycemia. Methods. Ten adult subjects with type 1 diabetes had hypoglycemia induced by intravenous injection of two insulin types in a cross-over design. QT measurements were done using the slope-intersect (SI) and manual annotation (MA) methods. Heart rate correction was done using Bazett's (QTcB) and Fridericia's (QTcF) formulas. Results. The SI method showed significant prolongation at hypoglycemia for QTcB (42(6) ms; P < .001) and QTcF (35(6) ms; P < .001). The MA method showed prolongation at hypoglycemia for QTcB (7(2) ms, P < .05) but not QTcF. No difference in ECG variables between the types of insulin was observed. Discussion. The method for measuring the QT interval has a significant impact on the prolongation of QT during hypoglycemia. Heart rate correction may also influence the QT during hypoglycemia while the type of insulin is insignificant. Prolongation of QTc in this study did not reach pathologic values suggesting that QTc prolongation cannot fully explain the dead-in-bed syndrome.
authors.affiliation: Device R&D, Novo Nordisk, Brennum Park 20A1.105, 3400 Hillerød, Denmark.
authors.forename: Toke Folke
authors.initials: TF
authors.lastname: Christensen
authors.forename: Jette
authors.initials: J
authors.lastname: Randløv
authors.forename: Leif Engmann
authors.initials: LE
authors.lastname: Kristensen
authors.forename: Ebbe
authors.initials: E
authors.lastname: Eldrup
authors.forename: Ole Kristian
authors.initials: OK
authors.lastname: Hejlesen
authors.forename: Johannes Jan
authors.initials: JJ
authors.lastname: Struijk