title: Gene knockout on P-selectin: Its biology and function.
abstract: P-selectin is a leukocyte adhesion molecule present on the surfaces of activated platelets and endothelial cells. Its expression has been documented at sites of active inflammation including that resulting from cardiovascular disease. Mice deficient in P-selectin, generated by gene targeting, have provided tools for understanding the role of P-selectin in mediating the complex processes that lead to leukocyte extravasation in inflammatory processes. This review discusses the generation and characterization of P-selectin-deficient mice and our current understanding of P-selectin's role in mediating leukocyte-endothelial and leukocyte-platelet interactions.
authors.affiliation: Tanya N. Mayadas is at the Vascular Research Division, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: T N
authors.initials: TN
authors.lastname: Mayadas