title: [Role of serotonergic neurons in dorsal raphe nuclei in regulation of sleep].
abstract: OBJECTIVE
  To investigate the roles of serotonergic neurons in dorsal raphe nuclei (DRN) in sleep.
  
  
  METHODS
  Stereotaxic, microinjection and polysomnography (PSG) were used in the experiment.
  
  
  RESULTS
  Microinjection of L-glutanate (L-Glu) into the DRN decreased slow wave sleep (SWS) and paradoxical sleep (PS), and increased wake (W). Microinjection of kainic acid (KA) and p-chlorophenylalanine (PCPA) respectively into the DRN, SWS and PS were promoted, and W was reduced.
  
  
  CONCLUSIONS
  Serotonergic neurons in dorsal raphe nuclei involved in the regulation of sleep. Sleep was reduced when the serotonergic neurons were excited, and when the neurons were inhibited. sleep was increased
authors.affiliation: Department of Physiology, Anhui Medical University, Hefei 230032, China.
authors.forename: Le-zhang
authors.initials: LZ
authors.lastname: Zhao
authors.forename: Gong-liang
authors.initials: GL
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Jing-xing
authors.initials: JX
authors.lastname: Zhang
authors.forename: Ming-kui
authors.initials: MK
authors.lastname: Zhong
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000200:Action Potentials; D000818:Animals; D008297:Male; D009474:Neurons / Q000502:physiology; D017286:Polysomnography; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
chemical_list: D012701:Serotonin