title: Impact of depression mood disorder on the adverse drug reaction incidence rate of anticancer drugs in cancer patients.
abstract: The aim of this study was to explore the impact of depression mood disorder on the incidence of adverse drug reactions of anticancer drugs in cancer patients. The Hamilton Depression Scale 17 was used to evaluate the depression mood disorder level in 73 cancer patients before chemotherapy. Pharmacists monitored adverse drug reactions during the chemotherapy period. The relationship between depression mood disorder level and the incidence of adverse drug reactions was analysed. The frequency and extent of total adverse drug reactions were not related to depression mood disorder level. The frequency and extent of subjectively experienced adverse drug reactions such as anorexia, nausea and fatigue were related to depression mood disorder level. In conclusion, psychological support and intervention should be provided to cancer patients in order to improve patient adherence and cancer chemotherapy effectiveness, and to decrease the incidence of adverse drug reactions.
authors.affiliation: Department of Clinical Pharmacology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: T
authors.initials: T
authors.lastname: Zhou
authors.forename: J J
authors.initials: JJ
authors.lastname: Duan
authors.forename: G P
authors.initials: GP
authors.lastname: Zhou
authors.forename: J Y
authors.initials: JY
authors.lastname: Cai
authors.forename: Z H
authors.initials: ZH
authors.lastname: Huang
authors.forename: Y T
authors.initials: YT
authors.lastname: Zeng
authors.forename: F
authors.initials: F
authors.lastname: Xu
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000150:complications* / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy* / Q000523:psychology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents