title: Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging.
abstract: It is well established that memory formation and retention involve the coordinated flow of information from the post-synaptic site of particular neuronal populations to the nucleus, where short and long-lasting modifications of gene expression occur. With age, mnemonic, motor and sensorial alterations occur, and it is believed that extra failures in the mechanisms used for memory formation and storage are the cause of neurodegenerative pathologies like Alzheimer's disease. A prime candidate responsible for damage and loss of function during aging is the accumulation of reactive oxygen species, derived from normal oxidative metabolism. However, dysfunction in the aged brain is not paralleled by an increase in neuronal death, indicative that the brain is better suited to fight against the death signals generated from reactive oxygen species than against loss-of-function stimuli. A main aim of this laboratory is to understand how neurons perform and survive in the constitutive stress background represented by aging. In this report, we summarize our recent findings in relation to survival.
authors.affiliation: VIB Department of Molecular and Developmental Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Alejandro O
authors.initials: AO
authors.lastname: Sodero
authors.forename: Laura
authors.initials: L
authors.lastname: Trovò
authors.forename: Francesca
authors.initials: F
authors.lastname: Iannilli
authors.forename: Paul
authors.initials: P
authors.lastname: Van Veldhoven
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Dotti
authors.forename: Mauricio G
authors.initials: MG
authors.lastname: Martin
mesh_terms: D000375:Aging; D000818:Animals; D016923:Cell Death / Q000502:physiology; D002784:Cholesterol / Q000378:metabolism*; D000072556:Cholesterol 24-Hydroxylase; D006624:Hippocampus / Q000166:cytology* / Q000201:enzymology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000201:enzymology*; D018384:Oxidative Stress / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013250:Steroid Hydroxylases / Q000378:metabolism*; D013312:Stress, Physiological / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology
chemical_list: D002784:Cholesterol; D013250:Steroid Hydroxylases; D000072556:Cholesterol 24-Hydroxylase; D011505:Protein-Tyrosine Kinases