title: Antiviral activity of the effective monomers from Folium Isatidis against influenza virus in vivo.
abstract: In order to evaluate the anti-influenza virus activity of the effective monomer from Folium Isatidis (FI) in vivo, we established mice model with viral pneumonia and divided them into 3 different dose groups, then observed their lung indexes, pulmonary pathological changes, pulmonary virus hemagglitination titers, living time and death rates. The results showed that the monomer could reduce the pulmonary index from 2.64 to 1.93, 1.63 and 1.40 (P<0.01) and decrease the hemagglitination titer from 1.15 to 0.84, 0.70 and 0.59 (P<0.01). In addition, different groups of FI could significantly lessen the mortality rate from 100% to 30%, 25% and 15%, and prolong the living time from 5.1d to 6.5d, 8.4d and 8.9 d respectively(P<0.01). The high dose (75 mg/kg/d) has the similar effect with 100 mg/kg/d dose of virazole(P>0.05), and more effective than 200 mg/kg/d dose of antiviral liquor (P<0.05).
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China. fanfangfei@yahoo.com.cn
authors.forename: Zhao
authors.initials: Z
authors.lastname: Liu
authors.forename: Zhan-qiu
authors.initials: ZQ
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000302:isolation & purification / Q000494:pharmacology; D002642:Chick Embryo; D004195:Disease Models, Animal; D005260:Female; D031219:Isatis / Q000737:chemistry*; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000472:pathogenicity; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000821:virology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D012129:Respiratory Function Tests; D016019:Survival Analysis; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts