title: Evaluation of medical and surgical management of critical extremity ischemia caused by atherothrombosis.
abstract: OBJECTIVE
  To assess efficacy of surgical and medical (conservative) treatment of acute exacerbation of chronic extremity ischemia by evaluating their early therapeutic outcomes in terms of mortality, extremity amputation and reamputation rate, limb salvage rate and length of hospitalization period.
  
  
  METHODS
  Patients were divided into two groups based on method used for the treatment of critical ischemia. Group A consisted of 40 patients that were subjected to surgical treatment of critical extremity ischemia during period 2004-2009. All patients were subjected to thrombectomy in local anesthesia (2% lidocaine) as initial step of treatment protocol. Urgent Seldinger angiography was performed for all patients that have undergone thrombectomy regardless of successfulness of thrombectomy. Based on angiography findings decision was made about further definitive treatment. It consisted of either using antiaggregating drugs (acetyl salicylic acid; 150 mg/day) if no significant postthrombectomy stenotic lesion was found or subjecting patients to further surgical revascularization in the form of bypass were significant stenosis or occlusion was identified. Group B consisted of 40 patients; all of them received conventional heparin anticoagulation therapy supplemented with vasoactive infusion treatment (Pentoxyohylline 300 mg/day) during period 1998-2004. On the third day of hospitalization oral anticoagulation (Sintrom) was included in the therapy protocol using dosage 2-8 mg/day in order to achieve INR 2-4, once therapeutic INR was obtained heparin was withdrawn. Study was clinical, designed as retrospective prospective and was conducted at the Clinic for vascular surgery in Sarajevo.
  
  
  RESULTS
  Mean age in group A was 66,5 years and in group B it was 65,78 years. Lenght of hospital stay in group A was 13,78 days while in group B it was 34,25 days (P value < 0,001). Limb salvage rate was 70% in group A and 17,5% in group B (P value < 0,001). In group A, nine amputations were performed (22,5%) while in group B we had to perform 38 amputations (95%), P value < 0,001. Only one reamputation was performed in group A (2,5% of patients) while in group B ten reamputations were performed (25% of patients). Mortality rate between groups was not statistically significant (P value < 0,077).
  
  
  CONCLUSIONS
  Surgical thrombectomy as introduction to definitive treatment of critical limb ischemia caused by atherothrombosis gives statistically superior results in comparison to conservative treatment.
authors.affiliation: Clinic for Vascular Surgery, Clinical Center of University of Sarajevo, Cekalusa 88, Sarajevo, Bosnia and Herzegovina. nrustempasic@yahoo.com
authors.forename: Nedzad
authors.initials: N
authors.lastname: Rustempasic
authors.forename: Emir
authors.initials: E
authors.lastname: Solakovic
authors.forename: Medzida
authors.initials: M
authors.lastname: Rustempasic
authors.forename: Izet
authors.initials: I
authors.lastname: Masic
mesh_terms: D000208:Acute Disease; D000368:Aged; D000671:Amputation, Surgical; D000792:Angiography; D000925:Anticoagulants / Q000627:therapeutic use; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D058226:Plaque, Atherosclerotic / Q000150:complications*; D017131:Thrombectomy; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*
chemical_list: D000925:Anticoagulants