title: High serum adiponectin is associated with favorable lipoprotein subclass profile in 6.4-year follow-up.
abstract: OBJECTIVE
  Adiponectin is linked to a favorable lipoprotein profile, but potential longitudinal associations are not known.
  
  
  METHODS
  A population-based follow-up study of all inhabitants born in 1942, 1947, 1952, and 1957 (n=1294) in Pieksämäki, a town in Finland. Of the 690 subjects participating in both the check-ups, 228 subjects with diabetes or any medication for dyslipidemia, high blood pressure, or diabetes were excluded. The final study population consisted of 462 (182 men and 280 women) apparently healthy subjects.
  
  
  METHODS
  Main outcome measures were lipoprotein particle sizes and concentrations, apolipoprotein A-1 (APOA1) and APOB levels at baseline and follow-up across baseline adiponectin tertiles. Serum adiponectin concentrations were determined using an enzyme immunoassay, and lipoprotein subclasses using proton nuclear magnetic resonance spectroscopy.
  
  
  RESULTS
  At the second health check-up 6.4 years later, the very low-density lipoprotein particle concentration decreased across the baseline adiponectin tertiles in men from 1.04 (0.28) to 0.91 (0.29) nmol/l (P for linearity=0.011) and in women from 0.92 (0.32) to 0.80 (0.24) nmol/l (P=0.002). Correspondingly, the mean high-density lipoprotein particle size increased from 9.78 to 9.90 nm in men (P<0.006) and from 10.00 to 10.14 nm in women (P<0.001).
  
  
  CONCLUSIONS
  The favorable links between adiponectin and lipoproteins are detectable 6.4 years later.
authors.affiliation: Unit of General Practice, Central Finland Central Hospital, Keskussairaalantie 19, 40620 Jyväskylä, Finland. mauno.vanhala@ksshp.fi
authors.forename: Mauno
authors.initials: M
authors.lastname: Vanhala
authors.forename: Linda S
authors.initials: LS
authors.lastname: Kumpula
authors.forename: Pasi
authors.initials: P
authors.lastname: Soininen
authors.forename: Antti J
authors.initials: AJ
authors.lastname: Kangas
authors.forename: Mika
authors.initials: M
authors.lastname: Ala-Korpela
authors.forename: Hannu
authors.initials: H
authors.lastname: Kautiainen
authors.forename: Pekka
authors.initials: P
authors.lastname: Mäntyselkä
authors.forename: Juha
authors.initials: J
authors.lastname: Saltevo
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D052242:Adiponectin; D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL