title: Effect of a prepregnancy pertussis booster dose on maternal antibody titers in young infants.
abstract: To examine the influence of a pertussis booster vaccination on the transfer of maternal antibodies, 24 nonpregnant women received a tetanus, diphtheria, acellular pertussis booster vaccine between 2 consecutive pregnancies. Blood was drawn from mothers and off-spring. Efficient transplacental antibody transfer and significantly higher antibody titers against 3 pertussis antigens were observed in cord blood and in blood of 1-month-old infants born after a maternal booster vaccination compared with results in their siblings born before the booster administration.
authors.affiliation: Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, WHO Collaborating Centre for Control and Prevention of Infectious Diseases, Faculty of Medicine, University of Antwerp, Antwerp, Belgium. Elke.leuridan@ua.ac.be
authors.forename: Elke
authors.initials: E
authors.lastname: Leuridan
authors.forename: Niel
authors.initials: N
authors.lastname: Hens
authors.forename: Natasja
authors.initials: N
authors.lastname: Peeters
authors.forename: Liene
authors.initials: L
authors.lastname: de Witte
authors.forename: Olivier
authors.initials: O
authors.lastname: Van der Meeren
authors.forename: Pierre
authors.initials: P
authors.lastname: Van Damme
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007117:Immunization, Secondary / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D011247:Pregnancy; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine