title: [Effect of losartan on produce of sera autoantibodies to angiotensin II-1 receptor in renovascular hypertension rats].
abstract: OBJECTIVE
  The effects of losartan (after operation 2 week to 10 week, 5 mg/kg d ig) on generation of AT1R-AA in sera were observed during development of hypertension in rats. The renovascular hypertension (RVH) model was established by two-kidney one-clip method, a synthetic peptide corresponding to amino acid sequence 165-191 of the second extracellular loop of the angiotensin II-1 receptor (AT1R) was used as antigen, SA-ELISA were used to examine sera AT1R autoantibody (AT1R-AA).
  
  
  RESULTS
  The frequencies and titres of AT1R-AA after operation one week rats were significantly increased (P < 0.05). The treatment with losartan not only inhibited structural and functional changes, but also the frequencies and titres of AT1R-AA was significantly lower (P < 0.05) than RVH group.
  
  
  CONCLUSIONS
  It is suggested that the losartan significantly inhibits generation of the AT1R-AA.
authors.affiliation: Department of Physiology, Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Zhi
authors.forename: Zhong-Bao
authors.initials: ZB
authors.lastname: Liu
authors.forename: Xiang-Ying
authors.initials: XY
authors.lastname: Jiao
authors.forename: Ying-Xu
authors.initials: YX
authors.lastname: Liu
authors.forename: Rong-Rui
authors.initials: RR
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D006978:Hypertension, Renovascular / Q000097:blood* / Q000276:immunology; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011945:Receptors, Angiotensin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D011945:Receptors, Angiotensin; D019808:Losartan