title: Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents.
abstract: BACKGROUND
  Whereas increased carbohydrate and sugar consumption has been associated with higher cardiovascular disease risk among adults, little is known about the impact of high consumption of added sugars (caloric sweeteners) among US adolescents.
  
  
  RESULTS
  In a cross-sectional study of 2157 US adolescents in the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004, dietary data from one 24-hour recall were merged with added sugar content data from the US Department of Agriculture MyPyramid Equivalents databases. Measures of cardiovascular disease risk were estimated by added sugar consumption level (< 10%, 10 to < 15%, 15 to < 20%, 20 to < 25%, 25 to < 30%, and ≥ 30% of total energy). Multivariable means were weighted to be representative of US adolescents and variances adjusted for the complex sampling methods. Daily consumption of added sugars averaged 21.4% of total energy. Added sugars intake was inversely correlated with mean high-density lipoprotein cholesterol levels (mmol/L) which were 1.40 (95% confidence interval [CI] 1.36 to 1.44) among the lowest consumers and 1.28 (95% CI 1.23 to 1.33) among the highest (P trend = 0.001). Added sugars were positively correlated with low-density lipoproteins (P trend =0.01) and geometric mean triglycerides (P trend = 0.05). Among the lowest and highest consumers, respectively, low-density lipoproteins (mmol/L) were 2.24 (95% CI 2.12 to 2.37) and 2.44 (95% CI 2.34 to 2.53), and triglycerides (mmol/L) were 0.81 (95% CI 0.74, 0.88) and 0.89 (95% CI 0.83 to 0.96). Among those overweight/obese (≥ 85th percentile body-mass-index), added sugars were positively correlated with the homeostasis model assessment (P linear trend = 0.004).
  
  
  CONCLUSIONS
  Consumption of added sugars among US adolescents is positively associated with multiple measures known to increase cardiovascular disease risk.
authors.affiliation: Nutrition and Health Science Program , Children's Healthcare of Atlanta, Atlanta, GA, USA. jwelsh1@emory.edu
authors.forename: Jean A
authors.initials: JA
authors.lastname: Welsh
authors.forename: Andrea
authors.initials: A
authors.lastname: Sharma
authors.forename: Solveig A
authors.initials: SA
authors.lastname: Cunningham
authors.forename: Miriam B
authors.initials: MB
authors.lastname: Vos
mesh_terms: D000293:Adolescent; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000517:prevention & control; D002648:Child; D019422:Dietary Sucrose / Q000008:administration & dosage*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009749:Nutrition Surveys / Q000706:statistics & numerical data*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D019422:Dietary Sucrose