title: Relationship of adiposity and insulin resistance mediated by inflammation in a group of overweight and obese Chilean adolescents.
abstract: The mild chronic inflammatory state associated with obesity may be an important link between adiposity and insulin resistance (IR). In a sample of 137 overweight and obese Chilean adolescents, we assessed associations between high-sensitivity C-reactive protein (hs-CRP), IR and adiposity; explored sex differences; and evaluated whether hs-CRP mediated the relationship between adiposity and IR. Positive relationships between hs-CRP, IR and 2 measures of adiposity were found. Hs-CRP was associated with waist circumference (WC) in boys and fat mass index (FMI) in girls. Using path analysis, we found that hs-CRP mediated the relationship between adiposity (WC and FMI) and the homeostatic model assessment of insulin resistance (HOMA-IR) (p < 0.05) in both sexes. Our novel finding is that inflammation statistically mediated the well described link between increased adiposity and IR.
authors.affiliation: Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. mreyes@inta.uchile.cl
authors.forename: Marcela
authors.initials: M
authors.lastname: Reyes
authors.forename: Sheila
authors.initials: S
authors.lastname: Gahagan
authors.forename: Erik
authors.initials: E
authors.lastname: Díaz
authors.forename: Estela
authors.initials: E
authors.lastname: Blanco
authors.forename: Laura
authors.initials: L
authors.lastname: Leiva
authors.forename: Lydia
authors.initials: L
authors.lastname: Lera
authors.forename: Raquel
authors.initials: R
authors.lastname: Burrows
mesh_terms: D050154:Adiposity; D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D002677:Chile / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000150:complications*; D012044:Regression Analysis; D012737:Sex Factors; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002097:C-Reactive Protein