title: [Hurthle cell thyroid tumor: an analysis of 28 cases].
abstract: OBJECTIVE
  To explore the clinical features and the combined treatment modality of Hurthle cell thyroid tumor (HCT).
  
  
  METHODS
  Twenty-eight cases of HCT treated between 2001 and 2009 were analyzed retrospectively.
  
  
  RESULTS
  The age of the patients ranged from 18 to 72 years (with a median of 46.5 years); 22 females and 6 males. The main symptoms were thyroid solitary node or mass (22 cases) and multiple nodule (6 cases), 2 cases with cervical lymph node metastasis. All of the patients underwent surgery, 11 cases with thyroid lobectomy, 11 cases with thyroid lobectomy plus isthmusectomy, 4 cases with subtotal thyroidectomy, and 2 cases with thyroid lobectomy plus isthmusectomy and combined with modified radical cervical lymph node dissection. Postoperative pathological examination showed that 22 cases were Hurthle cell adenomas and 6 cases were Hurthle cell carcinomas, 1 of them with cervical lymph node metastasis. Twenty-one patients with Hurthle cell adenomas were followed up for 6 months to 7.5 years (with a median of 45 months) and 6 patients with Hurthle cell carcinomas for 3 to 8 years (with a median of 54 months), with no recurrence and death case.
  
  
  CONCLUSIONS
  HCT is a potential malignant neoplasm. There are some difficulties in the diagnosis of HCT by frozen section. Surgery is an effective treatment for HCT. L-Thyroxine can be used to inhibit TSH excretion.
authors.affiliation: Department of Head Neck Surgery, Cancer Hospital Affiliated to Tianjin Medical University, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China. leonyang0104@tom.com
authors.forename: Xiao-yong
authors.initials: XY
authors.lastname: Yang
authors.forename: Chuan-xiang
authors.initials: CX
authors.lastname: Hu
authors.forename: Li-zhen
authors.initials: LZ
authors.lastname: Yang
authors.forename: Wen-chuan
authors.initials: WC
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D055815:Young Adult