title: Outcome of adjuvant therapy for gallbladder cancer.
abstract: OBJECTIVE
  The aim of this study was to evaluate the outcome of adjuvant therapy on the overall survival (OS) and disease-free survival (DFS) after curative resection (RO) of patients with TNM stage II gallbladder (GB) cancer.
  
  
  METHODS
  A total of 160 patients who had received curative resection (RO) between January 2000 and December 2009 were retrospectively reviewed. Among 61 stage II GB cancer patients, 43 received adjuvant therapy, while 18 others received surgery alone. The median follow-up period was 27.3 months (range 2.2-98.9 months).
  
  
  RESULTS
  OS was not significantly different among the adjuvant therapies (p = 0.180), but DFS was (p = 0.033). The 3-year OS and DFS from surgery alone, adjuvant chemotherapy, adjuvant radiotherapy, and adjuvant concurrent chemo-radiotherapy were 64, 78, 36 and 36%, and 56, 69, 14 and 47%, respectively. Overall, the chemotherapy group had a better prognosis, although there were no significant differences.
  
  
  CONCLUSIONS
  The data from this study do not provide evidence that adjuvant therapy is an effective treatment option for curative resected GB cancer. A large randomized controlled study is necessary to confirm the efficacy of adjuvant therapy. Newer adjuvant studies should be focused on gemcitabine-based chemotherapy or chemo-radiotherapy with molecular-based target agents.
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyung Soon
authors.initials: HS
authors.lastname: Park
authors.forename: Jae Yun
authors.initials: JY
authors.lastname: Lim
authors.forename: Dong Sup
authors.initials: DS
authors.lastname: Yoon
authors.forename: Joon Seong
authors.initials: JS
authors.lastname: Park
authors.forename: Dong Ki
authors.initials: DK
authors.lastname: Lee
authors.forename: Se Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Choi
authors.forename: Si Young
authors.initials: SY
authors.lastname: Song
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Lee
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Cho
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018196:Carcinoma, Adenosquamous / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005706:Gallbladder Neoplasms / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents