title: In vivo multiparametric magnetic resonance imaging and spectroscopy of rodent visual system.
abstract: The integrity of the neuronal connections between eye and brain plays an important role in the performance of the mammalian visual system. However, the developmental and pathophysiological mechanisms in the visual system are largely unexplored due to the lack of a sensitive technique for directly assessing both anterior and posterior visual pathways longitudinally under the same experimental conditions. This paper reviewed the recent use of magnetic resonance imaging and spectroscopic (MRI/MRS) methods (contrast-enhanced MRI, diffusion MRI, proton MRS and functional MRI) at high magnetic field strengths, for in vivo and global assessments of the structure, metabolism and function of the visual system in normal, developing and injured rodent brains. Using animal models of ocular diseases, optic neuropathies, developmental plasticity and neonatal hypoxic-ischemic brain injury, focus is put on the feasibility of MRI/MRS to evaluate axonal transport and cellular activity along segregated fibers of the visual pathways, to characterize lesion-induced neurodegeneration in the retina and the optic nerve and tract, to detect steady-state metabolite changes in the posterior visual nuclei, and blood-ocular dynamic exchanges in the eye, and to understand the neurovascular coupling and functions in the retina and the visual brain nuclei. These studies suggested the significant values of high-field multiparametric MRI/MRS for providing early diagnoses and comprehensive therapeutic strategies for promoting functional recovery upon partial vision loss.
authors.affiliation: Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Chan
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Cheung
authors.forename: Ed X
authors.initials: EX
authors.lastname: Wu
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D004195:Disease Models, Animal; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051379:Mice; D051381:Rats; D012377:Rodentia / Q000033:anatomy & histology / Q000502:physiology*; D014795:Visual Pathways / Q000033:anatomy & histology / Q000502:physiology*