title: Novel genetic findings in an extended family pedigree with sleepwalking.
abstract: BACKGROUND
  Sleepwalking is a common and highly heritable sleep disorder. However, inheritance patterns of sleepwalking are poorly understood and there have been no prior reports of genes or chromosomal localization of genes responsible for this disorder.
  
  
  OBJECTIVE
  To describe the inheritance pattern of sleepwalking in a 4-generation family and to identify the chromosomal location of a gene responsible for sleepwalking in this family.
  
  
  METHODS
  Nine affected and 13 unaffected family members of a single large family were interviewed and DNA samples collected. Parametric linkage analysis was performed.
  
  
  RESULTS
  Sleepwalking was inherited as an autosomal dominant disorder with reduced penetrance in this family. Genome-wide multipoint parametric linkage analysis for sleepwalking revealed a maximum logarithm of the odds score of 3.44 at chromosome 20q12-q13.12 between 55.6 and 61.4 cM.
  
  
  CONCLUSIONS
  Sleepwalking may be transmitted as an autosomal dominant trait with reduced penetrance. Here we describe the first genetic locus for sleepwalking at chromosome 20q12-q13.12.
authors.affiliation: Washington University School of Medicine, Department of Neurology, Campus Box 8111, 660 S Euclid Ave., St. Louis, MO 63110, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Licis
authors.forename: D M
authors.initials: DM
authors.lastname: Desruisseau
authors.forename: K A
authors.initials: KA
authors.lastname: Yamada
authors.forename: S P
authors.initials: SP
authors.lastname: Duntley
authors.forename: C A
authors.initials: CA
authors.lastname: Gurnett
mesh_terms: D000243:Adenosine Deaminase / Q000235:genetics; D002875:Chromosomes / Q000235:genetics*; D004264:DNA Topoisomerases, Type I; D005192:Family Health; D020869:Gene Expression Profiling / Q000379:methods; D008040:Genetic Linkage / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010375:Pedigree; D051966:Phospholipase C gamma; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2; D013009:Somnambulism / Q000235:genetics*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C107592:PKIG protein, human; C516865:PTPRT protein, human; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2; C522157:PLCG1 protein, human; D051966:Phospholipase C gamma; C548482:ADA protein, human; D000243:Adenosine Deaminase; D004264:DNA Topoisomerases, Type I; C528909:TOP1 protein, human