title: An overview of the diagnostic and therapeutic use of monoclonal antibodies in medicine.
abstract: Monoclonal antibodies, which include murine, chimeric, humanized and fully human antibodies, bind to their target receptors with high affinity and specificity. In the last two decades several different monoclonal antibodies have been approved by the Food and Drug Administration for therapeutic purposes, and some of these and others have also been radiolabelled for diagnostic and therapeutic purposes. This field is in continuous evolution and this overview highlights the role of radiolabelled antibodies in research and clinical setting.
authors.affiliation: New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, NY 10065, USA. sjg2002@med.cornell.edu
authors.forename: S J
authors.initials: SJ
authors.lastname: Goldsmith
authors.forename: A
authors.initials: A
authors.lastname: Signore
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003661:Decision Support Techniques; D006801:Humans; D007239:Infections / Q000000981:diagnostic imaging* / Q000628:therapy*; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000628:therapy*; D007553:Isotope Labeling / Q000639:trends; D057054:Molecular Imaging / Q000639:trends; D011868:Radioisotopes / Q000627:therapeutic use; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D019275:Radiopharmaceuticals