title: Response of NF1-related plexiform neurofibroma to high-dose carboplatin.
abstract: Plexiform neurofibromas (PN) are a hallmark of neurofibromatosis type 1 (NF1). These large nerve tumors can be disfiguring and surgery is the only known standard therapy. Surgical intervention may be suboptimal due to the diffuse nature of PN. Here, we present a case in which we describe the use of high-dose carboplatin to treat the patient's testicular seminoma which resulted in the decrease in size of a PN in a patient with NF1.
authors.affiliation: Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. trent.hummel@cchmc.org
authors.forename: Trent
authors.initials: T
authors.lastname: Hummel
authors.forename: Adjoa
authors.initials: A
authors.lastname: Anyane-Yeboa
authors.forename: Jun
authors.initials: J
authors.lastname: Mo
authors.forename: Alexander
authors.initials: A
authors.lastname: Towbin
authors.forename: Brian
authors.initials: B
authors.lastname: Weiss
mesh_terms: D000328:Adult; D016190:Carboplatin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018318:Neurofibroma, Plexiform / Q000188:drug therapy* / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016190:Carboplatin