title: Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1).
abstract: According to the structural characteristics of isoliquiritigenin from Glycyrrhiza uralensis, a series of hydroxychalcones has been designed, synthesized and evaluated for their in vitro inhibitory activities of β-secretase (BACE1). Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 μM).
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Yang
authors.forename: Chenjing
authors.initials: C
authors.lastname: Li
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xu
authors.initials: X
authors.lastname: Shen
authors.forename: Lihong
authors.initials: L
authors.lastname: Hu
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D047188:Chalcones; D004791:Enzyme Inhibitors; C451019:4-hydroxychalcone; D053829:Amyloid Precursor Protein Secretases