title: An enzyme-sensitive probe for photoacoustic imaging and fluorescence detection of protease activity.
abstract: A gold nanocage and dye conjugate has been demonstrated for use with photoacoustic imaging and fluorescence detection of protease activity. The detection sensitivity could be maximized by using gold nanocages with a localized surface plasmon resonance peak away from the emission peak of the dye. These hybrids can be potentially used as multimodal contrast agents for molecular imaging.
authors.affiliation: Department of Biomedical Engineering, Washington University in St Louis, MO 63130, USA. xia@biomed.wustl.edu
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Xia
authors.forename: Miaoxin
authors.initials: M
authors.lastname: Yang
authors.forename: L Kyle
authors.initials: LK
authors.lastname: Oetjen
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qingge
authors.initials: Q
authors.lastname: Li
authors.forename: Jingyi
authors.initials: J
authors.lastname: Chen
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D054459:Elasticity Imaging Techniques / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D008422:Materials Testing; D008856:Microscopy, Fluorescence / Q000379:methods*; D015336:Molecular Probe Techniques; D049329:Nanostructures / Q000737:chemistry*; D010447:Peptide Hydrolases / Q000032:analysis* / Q000737:chemistry*
chemical_list: D006046:Gold; D010447:Peptide Hydrolases