title: Tumor shrinkage of vestibular schwannomas after Gamma Knife surgery: results after more than 5 years of follow-up.
abstract: OBJECTIVE
  The authors prospectively analyzed volume changes in vestibular schwannomas (VSs) after Gamma Knife surgery (GKS).
  
  
  METHODS
  Among 104 VSs treated by GKS at the Chiba Cardiovascular Center between 1998 and 2004, 87 consecutively treated unilateral VSs observed on follow-up MR imaging for at least 5 years were analyzed. These lesions were harbored by 31 men and 56 women, with a mean age of 58.6 years (range 29–80 years). The Gd-enhanced volume of each lesion was measured serially every 3 months during the 1st year and every 6 months thereafter using Gamma Plan or SurgiPlan. The frequency and degree of volume shrinkage were documented and possible prognostic factors were analyzed.
  
  
  RESULTS
  The mean tumor volume at GKS was 2.5 cm3 (range 0.1–13.2 cm3). The lesions were irradiated by directing a mean dose of 12.0 Gy (range 10.5–13.0 Gy) to the tumor margin, which was located at the mean 52.2% isodose line (range 50%–67% isodose line). The mean follow-up period was 7.5 years (range 5.0–11.1 years). Peak tumor volume expansion was most frequently observed at 8.6 months after GKS and averaged 58% (range 0%–613%). Five years after GKS, the mean reduction in tumor volume was 31%, and 9 tumors still remained larger than their initial volumes. Tumors that homogeneously enhanced on MR images displayed less shrinkage than other tumors.
  
  
  CONCLUSIONS
  Most VSs exhibit shrinkage 5 years after GKS. The mean volume reduction in this series was 31%. These results indicate that careful serial follow-up is necessary for patients who harbor tumors that display homogeneous enhancement on MR images and patients whose tumors continue to expand in size after GKS. (DOI: 10.3171/2010.8.GKS10960)
authors.affiliation: Gamma Knife House, Chiba Cardiovascular Center, Ichihara, Tokyo. osamu5@xk9.so-net.ne.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Nagano
authors.forename: Toru
authors.initials: T
authors.lastname: Serizawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Higuchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Matsuda
authors.forename: Makoto
authors.initials: M
authors.lastname: Sato
authors.forename: Iwao
authors.initials: I
authors.lastname: Yamakami
authors.forename: Koichi
authors.initials: K
authors.lastname: Okiyama
authors.forename: Junichi
authors.initials: J
authors.lastname: Ono
authors.forename: Naokatsu
authors.initials: N
authors.lastname: Saeki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004428:Ear Neoplasms / Q000473:pathology / Q000601:surgery*; D017352:Echo-Planar Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology / Q000601:surgery*; D010292:Paresthesia / Q000209:etiology; D011379:Prognosis; D016634:Radiosurgery; D016896:Treatment Outcome; D020433:Trigeminal Nerve Diseases / Q000209:etiology