title: Efficient synthesis of new tetradentate ligands with potential applications for 64Cu PET-imaging.
abstract: We wish to report the synthesis of new tetradentate ligands in less than 3h in good to excellent yields from a commercially available compound using microwave-assisted technology. First tests of complexation showed a high ability of these ligands to chelate (64)Cu(II) in very diluted medium. These new systems have the potential to be used for nuclear medicine and particularly for PET-imaging.
authors.affiliation: CNRS, UMR 6230, Université de Nantes, Chimie et Interdisciplinarité: Synthèse Analyse Modélisation, UFR Sciences et Techniques, Nantes, France.
authors.forename: Ewen
authors.initials: E
authors.lastname: Bodio
authors.forename: Karine
authors.initials: K
authors.lastname: Julienne
authors.forename: Sébastien G
authors.initials: SG
authors.lastname: Gouin
authors.forename: Alain
authors.initials: A
authors.lastname: Faivre-Chauvet
authors.forename: David
authors.initials: D
authors.lastname: Deniaud
mesh_terms: D003300:Copper / Q000737:chemistry*; D003301:Copper Radioisotopes / Q000737:chemistry; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry; D008024:Ligands; D008872:Microwaves; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003301:Copper Radioisotopes; D006834:Hydrazines; D008024:Ligands; D019275:Radiopharmaceuticals; C029424:hydrazine; D003300:Copper