title: Effect of preliminary load of macrophages with silicium dioxide on phagocytosis of BCG strain micobacteria by macrophages and antimicrobial activity.
abstract: We studied the effect of preliminary loading of peritoneal macrophages with silicium dioxide on in vitro viability, phagocytosis of BCG strain mycobacteria, and the capability to destroy the phagocytosed mycobacterium tuberculosis. It was shown that preliminary loading of macrophages with silicium dioxide did not reduce their viability and stimulated phagocytosis of BCG strain mycobacteria, but reduced their antibacterial activity.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. arkhipov@soramn.ru
authors.forename: S A
authors.initials: SA
authors.lastname: Arkhipov
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupy
authors.forename: Yu S
authors.initials: YS
authors.lastname: Bugrimova
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D009163:Mycobacterium bovis / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology*; D012822:Silicon Dioxide / Q000494:pharmacology; D012830:Silicotuberculosis / Q000276:immunology*
chemical_list: D012822:Silicon Dioxide