title: Sobetirome: a selective thyromimetic for the treatment of dyslipidemia.
abstract: Atherosclerosis and its clinical sequelae still represent the primary cause of death in Western societies. During the past 25 years, a novel drug class to treat dyslipidemia, a main risk factor for coronary artery disease, emerged: liver- and thyroid hormone receptor isoform β-selective analogs. The present review will discuss the recent patents applied for sobetirome (GC-1), which set the course for the establishment of a novel approach to lower plasma cholesterol and triglycerides. We will focus on the major mechanisms conferring sobetirome lipid-lowering properties, including the induction of hepatic LDL receptor, the promotion of the so-called reverse cholesterol transport, and finally the induction of bile acid production and biliary sterol secretion. In summary, thyromimetics such as sobetirome may represent a useful treatment for combined hyperlipidemia, which is associated with a major cardiovascular risk.
authors.affiliation: Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria. ivan.tancevski@i-med.ac.at
authors.forename: Ivan
authors.initials: I
authors.lastname: Tancevski
authors.forename: Egon
authors.initials: E
authors.lastname: Demetz
authors.forename: Philipp
authors.initials: P
authors.lastname: Eller
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D018716:Molecular Mimicry; D010636:Phenols / Q000627:therapeutic use*; D011973:Receptors, LDL / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D000085:Acetates; D001647:Bile Acids and Salts; D015415:Biomarkers; C413355:GC 1 compound; D000960:Hypolipidemic Agents; D010636:Phenols; D011973:Receptors, LDL; D013963:Thyroid Hormones; D014280:Triglycerides; D002784:Cholesterol