title: Oral vaccination of Atlantic salmon (Salmo salar) against salmonid rickettsial septicaemia.
abstract: Effective oral immunization systems may be very helpful to the salmon industry, particularly during the seawater growth stages in which vaccination through injection is not possible. During the seawater growing stage, fish become more susceptible to several types of disease, due to the natural decay of vaccine-induced immune responses. In this study, we demonstrate the immune response and efficacy of a new salmonid rickettsial septicaemia (SRS) oral vaccine, developed using MicroMatrix™ Technology. The vaccine, which is administered together with daily feed ration, induces a specific immune response at local and systemic levels. Anti-Piscirickettsia salmonis specific antibodies were detected as soon as 300 degree-days after vaccination. Furthermore, oral vaccination was able to protect fish against a lethal pathogen challenge when administered either as a primary vaccination or as a booster for an injected vaccine. Results show that oral vaccination is an efficacious treatment for the prevention of SRS outbreaks throughout the salmon culture period.
authors.affiliation: Investigación y Desarrollo Biológicos, Laboratorio Centrovet, Santiago, Chile. jtobar@centrovet.com
authors.forename: Jaime A
authors.initials: JA
authors.lastname: Tobar
authors.forename: Sofía
authors.initials: S
authors.lastname: Jerez
authors.forename: Mario
authors.initials: M
authors.lastname: Caruffo
authors.forename: Catalina
authors.initials: C
authors.lastname: Bravo
authors.forename: Francisco
authors.initials: F
authors.lastname: Contreras
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Bucarey
authors.forename: Moti
authors.initials: M
authors.lastname: Harel
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000276:immunology*; D005393:Fish Diseases / Q000276:immunology / Q000517:prevention & control*; D018928:Immunity, Mucosal; D007117:Immunization, Secondary; D007075:Immunoglobulin M / Q000097:blood; D053522:Piscirickettsia / Q000276:immunology; D044225:Piscirickettsiaceae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D020317:Salmo salar / Q000276:immunology*; D015430:Weight Gain
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007075:Immunoglobulin M