title: Allometric scaling of orbifloxacin disposition in nine mammal species: a retrospective analysis.
abstract: The objective of this study was to analyze the relationship between pharmacokinetic parameters and body weight (W) for orbifloxacin using reported pharmacokinetic data. The parameters of interest: clearance (Cl), volume of distribution at steady state (Vss) and elimination half-life were correlated across nine mammal species, including cattle, dog, rat, rabbit, goat, camel, horse, cat and sheep as a function of W using the conventional allometric equation Y = aW(b), where Y is the pharmacokinetic parameter, W is the body weight, a is the allometric coefficient (intercept) and b is the exponent that describes the relationship between the pharmacokinetic parameter and W. Our estimates (Cl=4.40 W(1.03); Vss=1.10W(1.05)) indicated that the increase in these parameters with W approximates a linear power relationship with slopes being very close to one. Overall, the results of this study indicated that it is possible to use allometry to predict pharmacokinetic variables of orbifloxacin based on W of mammal species.
authors.affiliation: Laboratory of Veterinary Pharmacokinetics & Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, South Korea.
authors.forename: Elias
authors.initials: E
authors.lastname: Gebru
authors.forename: Seung-Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Jong-Choon
authors.initials: JC
authors.lastname: Kim
authors.forename: Seung-Chun
authors.initials: SC
authors.lastname: Park
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D001835:Body Weight / Q000502:physiology*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006207:Half-Life; D008297:Male; D008322:Mammals / Q000378:metabolism*; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; C095163:orbifloxacin