title: Is human papillomavirus a causative factor of glottic cancer?
abstract: OBJECTIVE
  Human papillomavirus (HPV) infection is controversial as a causative factor of head and neck cancers despite the relatively high frequency of HPV infection in extragenital organ cancers. We aimed to clarify whether HPV directly affects the oncogenesis and biologic behavior of glottis cancer (GC).
  
  
  METHODS
  Paraffin block was obtained from 95 patients who were diagnosed as GC and 15 normal controls. HPV genotyping chip, real-time polymerase chain reaction (PCR) was used for identification of prevalence, phenotype, and physical status of HPV. We compared results with the clinicopathological parameters of GC patients.
  
  
  RESULTS
  HPV was detected in 7.4% (7 of 95) of GC patients, whereas 0% (0 of 15) of controls. Of the HPV-positive tumors in GCs, HPV-16 was the single most common type and HPV-16 prevalence rate was 57.1% (4 of 7). Among the HPV-16 infected GCs, integration of HPV-16 was found only in one case (1 of 4). There was no significant difference in HPV prevalence between GC and controls and HPV had no significant relation with any clinicopathologic parameters of GC patients.
  
  
  CONCLUSIONS
  HPV infection may not be a causative factor in the oncogenesis and biologic behavior of GC.
authors.affiliation: Department of Otorhinolaryngology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Sei Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Nam Hoon
authors.initials: NH
authors.lastname: Cho
authors.forename: Eun Chang
authors.initials: EC
authors.lastname: Choi
authors.forename: Won Shik
authors.initials: WS
authors.lastname: Kim
authors.forename: Se-Heon
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D016022:Case-Control Studies; D005931:Glottis / Q000473:pathology; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology