title: Foregut duplication cysts: a report of two cases with emphasis on embryogenesis.
abstract: Duplication cyst of the stomach with a pseudostratified columnar ciliated epithelium is extremely rare. We describe two cases of these cysts, with emphasis on their immunophenotype and embryogenesis. The first patient was a 29-year-old man who presented with cramping abdominal pain in his left lower quadrant. The second patient was a 26-year-old woman who had a history, over several years, of chronic epigastric abdominal pain radiating to her back. Both lesions were surgically removed. They showed the same histomorphology. The cysts were lined by a pseudostratified respiratory epithelium with ciliated cells. The first cyst was connected to the stomach, while the second cyst was not connected. Both cysts expressed thyroid transcription factor-1 (TTF-1) and surfactant. In this report, we explore the possible embryogenesis of these lesions in the light of TTF-1 and surfactant expression.
authors.affiliation: Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, United States. thaer.khoury@roswellpark.org
authors.forename: Thaer
authors.initials: T
authors.lastname: Khoury
authors.forename: Louis
authors.initials: L
authors.lastname: Rivera
mesh_terms: D000328:Adult; D003560:Cysts / Q000378:metabolism / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000378:metabolism; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D013270:Stomach / Q000473:pathology*; D013272:Stomach Diseases / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; C504003:TTF1 protein, human; D014157:Transcription Factors