title: Immune modulation in heart failure: past challenges and future hopes.
abstract: Immune-modulation therapy has had great success in various inflammatory diseases. Despite the promising results of preliminary studies in anti-tumor necrosis factor-α therapies, large randomized studies have lacked positive clinical outcomes in patients with heart failure. These results have led to the idea that therapies directed toward specific inflammatory mediators may not be the answer and lead us toward the development of novel anti-inflammatory strategies that may involve a broader spectrum of inflammatory mediators. Therapeutic plasma exchange has been demonstrated as a safe treatment, and preliminary outcomes led us to develop new treatment schemes.
authors.affiliation: Methodist DeBakey Heart Center, The Methodist Hospital, 6550 Fannin Street, Houston, TX 77030, USA.
authors.forename: Jose H
authors.initials: JH
authors.lastname: Flores-Arredondo
authors.forename: Gerardo
authors.initials: G
authors.lastname: García-Rivas
authors.forename: Guillermo
authors.initials: G
authors.lastname: Torre-Amione
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology; D006333:Heart Failure / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D007155:Immunologic Factors