title: [Efficacy of short-term high volume (6 g of 5-FU in a week) hepatic arterial infusion for synchronous diffuse liver metastases of sigmoid colon cancer with over 40 thousand ng/mL of CEA of ascites].
abstract: We report a case of patient who recovered from liver failure with synchronous diffuse liver metastases of sigmoid colon cancer by a short-term high volume (6 g of 5-FU in a week) hepatic arterial infusion (STHV-HAI). After four times of STHV-HAI, she had sigmoidectomy and bilateral oohorectomy and continued a weekly hepatic arterial infusion therapy until now. The case was a 75-year-old lady. She admitted of general fatigue. Serum bilirubin was about 2 mg/dL, GOT about 200 U/L and CEA over 40 thousand ng/mL. She started STHV-HAI next day of her admission. After 4-course, her liver function became normal and the amount of CEA level became about 1,000 ng/mL. We had the operation of sigmoidectomy and bilateral oohorectomy. After that, she received the HAI every week as an outpatient. The lowest level of CEA became at the 90 ng/mL. The liver metastases were also almost CR. STHV-HAI will be safe and effective to a patient of liver metastases with ascites and jaundice.
authors.affiliation: Dept. of Surgery, Nishinomiya Watanabe Hospital.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Higuchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Atsuya
authors.initials: A
authors.lastname: Okada
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001201:Ascites / Q000150:complications; D001202:Ascitic Fluid / Q000737:chemistry*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D012809:Colon, Sigmoid / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D010052:Ovariectomy; D012074:Remission Induction; D012811:Sigmoid Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002272:Carcinoembryonic Antigen; D005472:Fluorouracil