title: Reversible course of pulmonary arterial hypertension related to bone marrow transplantation.
abstract: Pulmonary arterial hypertension (PAH) is considered to be a rare but serious complication of bone marrow transplantation (BMT). The majority of the reports demonstrated a potential fatal outcome, while treatments are postulated to require an indefinite duration. Our objective is to describe cases of reversible PAH related to BMT in two patients. Two patients with PAH after BMT were investigated for the common secondary causes of PAH. Both results were negative. The first patient was a 19-year-old male. He was diagnosed with relapse acute lymphoblastic leukemia, underwent BMT, and developed PAH 10 months after transplantation. He was initially treated with iloprost and sildenafil. His functional class gradually improved while his medication was titrated down and switched to amlodipine. His pulmonary arterial pressure has been normalized. The second patient is a 20-year-old female, with a confirmed case of chronic myeloid leukemia, who underwent BMT and developed PAH 4 months after BMT. She was treated with sildenafil and beraprost. With improvement of her symptoms and normal exercise test, her medication was discontinued after 4 months of therapy while her pulmonary pressure currently remains normal. BMT was considered to be an uncommon cause of PAH, which is amenable to reversibility.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. alimsuwan@yahoo.com
authors.forename: Alisa
authors.initials: A
authors.lastname: Limsuwan
authors.forename: Samart
authors.initials: S
authors.lastname: Pakakasama
authors.forename: Suradej
authors.initials: S
authors.lastname: Hongeng
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D065627:Familial Primary Pulmonary Hypertension; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents