title: How shelterin solves the telomere end-protection problem.
abstract: The symphony of the human genome concludes with a long Gregorian chant of TTAGGG repeats. This monotonous coda represents one of the most complex problems in chromosome biology: the question of how cells distinguish their natural chromosome ends from double-strand breaks elsewhere in the genome. McClintock's classic finding of chromosome breakage-fusion-bridge cycles, first reported by her at one of the early Cold Spring Harbor Laboratory Symposia (the ninth), served as a prelude to this question. The 75th Cold Spring Harbor Laboratory Symposium marks the completion of a series of mouse gene deletion experiments that revealed DNA-damage-response pathways that threaten chromosome ends and how the components of the telomeric shelterin complex prevent activation of these pathways.
authors.affiliation: Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065, USA. delange@rockefeller.edu
authors.forename: T
authors.initials: T
authors.lastname: de Lange
mesh_terms: D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins; D001483:Base Sequence; D018797:Cell Cycle Proteins / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011995:Recombination, Genetic; D016615:Telomere / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D034501:Telomere-Binding Proteins; D025521:Tumor Suppressor Proteins; C576897:Atr protein, mouse; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; C576325:Atm protein, mouse; D017346:Protein Serine-Threonine Kinases