title: The relationship between interferon-γ gene polymorphism and acute kidney allograft rejection.
abstract: Cytokine gene polymorphisms have been associated with modified gene expression and cytokine production. Gamma interferon (IFN-γ) plays an important role in the pathogenesis of kidney transplant rejection. This study evaluated the association between IFN-γ gene polymorphisms and the history of acute allograft rejection in 53 adult first-transplant recipients receiving cadaveric kidney grafts. They were followed up in a single centre until 2006, for a median time of 4 years after transplantation (1-22 years). IFN-γ gene polymorphisms +874 T/A (rs2430561) were determined by polymerase chain reaction (PCR). T/T high IFN-γ genotype was found in 12, intermediate T/A in 29 and low A/A in 12 patients. Twenty-six acute kidney rejection episodes were evidenced in 20 patients, of which none occurred in the 12 patients with low IFN-γ genotype A/A. Age, gender, number of HLA (human leukocyte antigen) mismatches, ABO blood groups, HLA, time after transplantation, creatinine clearance and immunosuppressive regimens were excluded as confounding factors associated with IFN-γ genotype distribution between rejectors and non-rejectors. IFN-γ gene polymorphisms could be an important risk factor for acute kidney transplant rejection, whereas the low A/A IFN-γ genotype could be protective against rejection.
authors.affiliation: University Josip Juraj Strosmayer Faculty of Medicine Osijek, Osijek, Croatia and Clinical Hospital Center Osijek, Osijek, Croatia University Hospital Zagreb, Zagreb, Croatia.
authors.forename: L
authors.initials: L
authors.lastname: Zibar
authors.forename: J
authors.initials: J
authors.lastname: Wagner
authors.forename: D
authors.initials: D
authors.lastname: Pavlinić
authors.forename: J
authors.initials: J
authors.lastname: Galić
authors.forename: J
authors.initials: J
authors.lastname: Pasini
authors.forename: K
authors.initials: K
authors.lastname: Juras
authors.forename: J
authors.initials: J
authors.lastname: Barbić
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D000328:Adult; D000367:Age Factors; D000368:Aged; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005838:Genotype; D006084:Graft Rejection / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007371:Interferon-gamma / Q000235:genetics* / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics* / Q000276:immunology*; D012307:Risk Factors; D012737:Sex Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System; D006680:HLA Antigens; D007371:Interferon-gamma