title: Associations of anhedonia and cognition in persons with schizophrenia spectrum disorders, their siblings, and controls.
abstract: The aim of the current study was to investigate the levels of social and physical anhedonia, as measured with the Chapman Scales for social and physical anhedonia in groups of patients with schizophrenia spectrum psychosis (n = 91), their unaffected siblings (n = 105), and control subjects drawn from a general population (n = 67). The second aim was to explore the effect of physical and social anhedonia on neuropsychological variables. Subjects with schizophrenia spectrum disorder had significantly more anhedonia than population controls, but the unaffected siblings did not differ from controls. Subjects with schizophrenia spectrum disorders had generalized cognitive deficits. Unaffected sibling status predicted impairments in executive and performance speed measures. Elevated physical anhedonia associated with deficits in verbal functions, but this was not related to genetic liability to schizophrenia. In conclusion, social and physical anhedonia did not seem to mediate neuropsychological deficits of schizophrenia family members.
authors.affiliation: Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. annamaria.kuha@thl.fi
authors.forename: Annamaria
authors.initials: A
authors.lastname: Kuha
authors.forename: Jaana
authors.initials: J
authors.lastname: Suvisaari
authors.forename: Jonna
authors.initials: J
authors.lastname: Perälä
authors.forename: Mervi
authors.initials: M
authors.lastname: Eerola
authors.forename: Suoma S
authors.initials: SS
authors.lastname: Saarni
authors.forename: Timo
authors.initials: T
authors.lastname: Partonen
authors.forename: Jouko
authors.initials: J
authors.lastname: Lönnqvist
authors.forename: Annamari
authors.initials: A
authors.lastname: Tuulio-Henriksson
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D011618:Psychotic Disorders / Q000150:complications / Q000235:genetics* / Q000523:psychology*; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D012565:Schizophrenic Psychology; D035781:Siblings / Q000523:psychology*; D012931:Social Environment