title: Utility of the Millon Behavioral Medicine Diagnostic to predict medication adherence in patients diagnosed with heart failure.
abstract: Medication non-adherence is common and a primary reason for poor medical outcomes among individuals with heart failure (HF). This study's aims were to determine whether depression, hostility, and the personality-based Millon Behavioral Medicine Diagnostic (MBMD) Medication Abuse scale were associated with medication adherence (e.g., beta-blockers, ACE inhibitors, diuretics, statins) beyond contributions of demographic, medical, and psychosocial variables in an ethnically-diverse sample of 105 men and women diagnosed with HF. In hierarchical regression, greater MBMD Medication Abuse scale scores were associated with poorer adherence above and beyond both depression (β = .236, t[102] = 2.113, p = .037) and hostility (β = .244, t[102] = 2.506, p = .014). The Medication Abuse scale also completely mediated the relationship between adherence and depression. These findings suggest that personality measures such as the MBMD and hostility scales might be utilized in future studies investigating predictors of adherence and also used clinically to predict medication adherence among HF patients.
authors.affiliation: Department of Psychology, University of Miami, 5665 Ponce de Leon Blvd, Flipse Building, 4th Floor, Coral Gables, FL 33124, USA. k.farrell1@umiami.edu
authors.forename: Kristen
authors.initials: K
authors.lastname: Farrell
authors.forename: Biing-Jiun
authors.initials: BJ
authors.lastname: Shen
authors.forename: Stephen
authors.initials: S
authors.lastname: Mallon
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Penedo
authors.forename: Michael H
authors.initials: MH
authors.lastname: Antoni
mesh_terms: D000368:Aged; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology*; D006791:Hostility; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D010555:Personality Inventory / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D012044:Regression Analysis; D015203:Reproducibility of Results; D013223:Statistics as Topic; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents