title: Heritability of response inhibition in children.
abstract: We report the heritability of response inhibition, latency, and variability, which are potential markers of genetic risk in neuropsychiatric conditions. Genetic and environmental influences on cancellation and restraint, response latency, and variability measured in a novel variant of the stop signal task were studied in 139 eight-year-old twin pairs from a birth cohort. Cancellation (50%), restraint (27%), and response latency (41%) showed significant heritability, the balance being non-shared environmental influences and/or error. Response variability was not heritable, with 23% of the variance attributable to shared environmental influences and 77% to non-shared environmental risk or error. The phenotypic correlation between response cancellation and restraint was -.44 and between response latency and restraint was .21. These phenotypic correlations were entirely genetic in origin. The phenotypic correlation between response variability and % successful inhibition was .27, but was not genetic. Cancellation and restraint were heritable and shared genetic influences, indicating that they may be influenced by a common gene or genes. Response latency was moderately heritable and shared genetic influences with restraint, but was not correlated with cancellation. Response variability was not heritable. These results support the potential of response inhibition and latency as endophenotypes in genetic research.
authors.affiliation: Neurosciences and Mental Health Programme, Research Institute and the Department of Psychiatry, The Hospital for Sick Children & University of Toronto, Toronto, Canada. russell.schachar@sickkids.ca
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Schachar
authors.forename: Nadine
authors.initials: N
authors.lastname: Forget-Dubois
authors.forename: Ginette
authors.initials: G
authors.lastname: Dionne
authors.forename: Michel
authors.initials: M
authors.lastname: Boivin
authors.forename: Philippe
authors.initials: P
authors.lastname: Robaey
mesh_terms: D002170:Canada; D002648:Child; D002652:Child Behavior / Q000502:physiology; D015331:Cohort Studies; D004777:Environment; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008957:Models, Genetic; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000235:genetics*; D014427:Twins