title: Dynamic simulations of multicomponent lipid membranes over long length and time scales.
abstract: We present a stochastic phase-field model for multicomponent lipid bilayers that explicitly accounts for the quasi-two-dimensional hydrodynamic environment unique to a thin fluid membrane immersed in aqueous solution. Dynamics over a wide range of length scales (from nanometers to microns) for durations up to seconds and longer are readily accessed and provide a direct comparison to fluorescence microscopy measurements in ternary lipid-cholesterol mixtures. Simulations of phase separation kinetics agree with experiment and elucidate the importance of hydrodynamics in the coarsening process.
authors.affiliation: Department of Physics, University of California, Santa Barbara, California 93106, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Camley
authors.forename: Frank L H
authors.initials: FL
authors.lastname: Brown
mesh_terms: D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D057446:Hydrodynamics; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D013269:Stochastic Processes; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D014867:Water