title: rs5848 variant of progranulin gene is a risk of Alzheimer's disease in the Taiwanese population.
abstract: Progranulin is the precursor of granulins, and its downregulation may lead to neurodegeneration. The single-nucleotide polymorphism rs5848 increases the risk of Alzheimer's disease (AD). We explored the association between alleles of rs5848 and the risk of AD in the Taiwanese population. The frequency of the homozygous TT genotype (16.4 vs. 10.0%) increased in AD subjects by an odds ratio (OR) of 1.87 (p = 0.03) corrected for APOE ε4, age and gender. Interaction between age and homozygous TT genotype accentuated the risk of AD (OR 4.44, p < 0.001). The homozygous TT genotype of rs5848 may play a role in the genetic risk of AD development, especially in the elderly.
authors.affiliation: Department of Neurology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan, ROC.
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Lee
authors.forename: Ta-Fu
authors.initials: TF
authors.lastname: Chen
authors.forename: Ting-Wen
authors.initials: TW
authors.lastname: Cheng
authors.forename: Ming-Jang
authors.initials: MJ
authors.lastname: Chiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000077153:Progranulins; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D013624:Taiwan
chemical_list: D001057:Apolipoproteins E; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins