title: [Clinicopathological features of primary splenic histiocytic sarcoma: a case report and literature review].
abstract: OBJECTIVE
  To study the clinicopathological features of primary splenic histiocytic sarcoma.
  
  
  METHODS
  Clinicopathological characterstics were analyzed in a case of primary splenic histiocytic sarcoma and related literatures were reviewed.
  
  
  RESULTS
  A 69-year old woman had unexplained debility and palpitation after exertion for a month. CT showed splenomegaly with multiple occupancy. The resected spleen measured 28 cm × 18 cm × 10 cm. Histopathological examination demonstrated that the neoplastic cells diffusely infiltrated splenic sinus. The neoplastic cells were characterized by well-defined cell contour, large pleomorphic nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. Tumor cells with cytoplasmic vacuoles and intense hemophagocytosis were observed. These cells strongly expressed histiocytic markers CD68 and CD163. Immunostaining for LCA, Vim was positive, but negative for CD1a, S-100, CD30, CK, CD20, CD3, CD21.
  
  
  CONCLUSIONS
  Immunohistochemistry plays a key role in the diagnosis of primary splenic histiocytic sarcoma.
authors.affiliation: China-Japanese Clinical Pathology Centre of Dalian Medical University, Dalian 116044, China.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Zhang
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
mesh_terms: D054747:Histiocytic Sarcoma; D006801:Humans; D007150:Immunohistochemistry; D012509:Sarcoma