title: Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women.
abstract: While nifedipine is commonly used for tocolysis, the controversy on its safety remains. So far, the haemodynamic effects on maternal and fetal circulations have not been well documented. Fifteen normotensive women who received 20 mg nifedipine were included in this prospective observational study. The maternal and fetal haemodynamic effects were analysed using maternal echocardiography and fetal Doppler ultrasonography. Nifedipine induced a significant afterload reduction in all women. It triggered a compensatory increase in cardiac output, which maintained blood pressure. These maternal changes had no influence on the uteroplacental and fetal circulations.
authors.affiliation: Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology Department of Cardiology Department of Biostatistics, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Cornette
authors.forename: J J
authors.initials: JJ
authors.lastname: Duvekot
authors.forename: J W
authors.initials: JW
authors.lastname: Roos-Hesselink
authors.forename: W C J
authors.initials: WC
authors.lastname: Hop
authors.forename: E A P
authors.initials: EA
authors.lastname: Steegers
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D009543:Nifedipine / Q000494:pharmacology*; D011247:Pregnancy; D011446:Prospective Studies; D018608:Ultrasonography, Doppler; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D009543:Nifedipine