title: HNO signaling mechanisms.
abstract: Due to recent discoveries of important and novel biological activity, nitroxyl (HNO) has become a molecule of significant interest. Although it has been used in the past as a treatment for alcoholism, it is currently being touted as a treatment for heart failure. It is becoming increasingly clear that many of the biological actions of HNO can be attributed to its ability to react with specific thiol- and, possibly, heme-proteins. Herein is discussed the chemistry of HNO with likely biological targets. A particular focus is given to targets associated with the pharmacological utility of HNO as a cardiovascular agent and for the treatment of alcoholism.
authors.affiliation: Department of Chemistry, Sonoma State University, Rohnert Park, California 94928, USA. jon.fukuto@sonoma.edu
authors.forename: Jon M
authors.initials: JM
authors.lastname: Fukuto
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Carrington
mesh_terms: D000818:Animals; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry / Q000378:metabolism; D009589:Nitrogen Oxides / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism
chemical_list: D008667:Metalloproteins; D009589:Nitrogen Oxides; D013438:Sulfhydryl Compounds; C039900:nitroxyl