title: Renal transplantation in an HIV-infected patient: pharmacokinetic aspects.
abstract: The introduction of highly active antiretroviral therapy in the mid-1990s led to a dramatic reduction in mortality and progression to AIDS, and human immunodeficiency virus (HIV)infection has now turned into a chronic disease with improved survival and prognosis. Hence, patients with well-controlled HIV infection are no longer prevented from receiving transplants, but treatment must be based on knowledge of pharmacokinetics for the drugs involved. The common approach measuring the cyclosporine level after 2 h or trough level is misleading and it was necessary to determine the area under the curve.
authors.affiliation: Department of Renal Medicine, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark. karenalstrup@dadlnet.dk
authors.forename: Karen
authors.initials: K
authors.lastname: Alstrup
authors.forename: Ida
authors.initials: I
authors.lastname: Kangas
authors.forename: Alex Lund
authors.initials: AL
authors.lastname: Laursen
authors.forename: Kaj Anker
authors.initials: KA
authors.lastname: Jørgensen
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D019540:Area Under Curve; D016572:Cyclosporine / Q000493:pharmacokinetics* / Q000627:therapeutic use; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male
chemical_list: D019380:Anti-HIV Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human