title: Mixtures of oseltamivir-sensitive and -resistant pandemic influenza A/H1N1/2009 viruses in immunocompromised hospitalized children.
abstract: We report on 3 immunocompromised children infected with pandemic influenza A/H1N1/2009 in whom mixtures of oseltamivir-susceptible and oseltamivir-resistant viral populations developed, despite them receiving relatively short-term courses of oseltamivir. In addition, it was found that bacterial coinfections were common, indicating that empiric, antibiotics should be considered in such patients when infected with influenza virus.
authors.affiliation: Department of Paediatrics, National University of Singapore, Singapore.
authors.forename: Mas
authors.initials: M
authors.lastname: Suhaila
authors.forename: Julian W
authors.initials: JW
authors.lastname: Tang
authors.forename: Hong Kai
authors.initials: HK
authors.lastname: Lee
authors.forename: Cui
authors.initials: C
authors.lastname: Lin
authors.forename: Paul A
authors.initials: PA
authors.lastname: Tambyah
authors.forename: Hui Kim
authors.initials: HK
authors.lastname: Yap
authors.forename: Seng Hock
authors.initials: SH
authors.lastname: Quak
authors.forename: Evelyn S C
authors.initials: ES
authors.lastname: Koay
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001424:Bacterial Infections / Q000453:epidemiology; D002648:Child; D002673:Child, Hospitalized; D002675:Child, Preschool; D024882:Drug Resistance, Viral; D014644:Genetic Variation; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D008297:Male; D053139:Oseltamivir / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir