title: [Anti-inflammatory and immune modulation therapy against atherosclerosis].
abstract: Atherosclerosis is a chronic inflammatory disease and many kinds of inflammatory cells and their releasing molecules are profoundly associated with the initiation and progression of the disease. However, we never have clinical therapeutic methods to directly intervene the inflammation or to modulate the immune system for preventing atherosclerosis so far. This article will focus on the recent experimental anti-inflammatory and immune modulatory therapies including active vaccination and induction of immune tolerance. We introduce our new experimental trial to develop a new immune therapy against atherosclerosis. We hope some novel therapies could be applied to clinics in the near future.
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Yamashita
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000906:Antibodies / Q000008:administration & dosage; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D017252:CD3 Complex / Q000276:immunology; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy / Q000379:methods*; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D007422:Intestines / Q000276:immunology; D008077:Lipoproteins, LDL / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014611:Vaccination
chemical_list: D000906:Antibodies; D017252:CD3 Complex; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein