title: The physiological function of store-operated calcium entry.
abstract: Store-operated Ca(2+) entry is a process whereby the depletion of intracellular Ca(2+) stores signals the opening of plasma membrane Ca(2+) channels. It has long been thought that the main function of store-operated Ca(2+) entry was the replenishment of intracellular Ca(2+) stores following their discharge during intracellular Ca(2+) signaling. Recent results, however, suggest that the primary function of these channels may be to provide direct Ca(2+) signals to recipients localized to spatially restricted areas close to the sites of Ca(2+) entry in order to initiate specific signaling pathways.
authors.affiliation: National Institute of Environmental Health Sciences-NIH, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA. putney@niehs.nih.gov
authors.forename: James W
authors.initials: JW
authors.lastname: Putney
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D000071740:ORAI1 Protein; D000071738:Stromal Interaction Molecule 2; D050052:TRPC Cation Channels / Q000502:physiology
chemical_list: D015220:Calcium Channels; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008565:Membrane Proteins; D000071740:ORAI1 Protein; C513279:STIM2 protein, human; D000071738:Stromal Interaction Molecule 2; D050052:TRPC Cation Channels; C510747:olf186-F protein, Drosophila; D002118:Calcium