title: [The effect of ARB on prevention of atherosclerosis].
abstract: Atherosclerosis is an inflammatory disease of vascular wall initiated and amplified by oxidative stress. Evidence has accumulated over the past decade that angiotensin II (Ang II) induces oxidative stress in hypertension which is one of the major risk factors of atherosclerosis. Angiotensin receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs) can reduce oxidative stress and inflammation in hypertensive patients. As a result, ACEIs reduce major cardiovascular events including myocardial infarction, stroke, and heart failure, whereas it has not been elucidated whether ARBs might be more effective at reducing atherosclerosis than ACEIs or not. The recent meta-analysis have been leading to the answer that ARBs should be considered as baseline therapy in hypertension.
authors.affiliation: Department of Cardiology, Gifu University Hospital.
authors.forename: Takuma
authors.initials: T
authors.lastname: Aoyama
authors.forename: Shinya
authors.initials: S
authors.lastname: Minatoguchi
mesh_terms: D000804:Angiotensin II / Q000502:physiology; D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control; D018384:Oxidative Stress; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000517:prevention & control
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II