title: Effect of dialysis on cerebral blood flow in depressive end-stage renal disease patients.
abstract: OBJECTIVE
  The aim of this study was to investigate regional cerebral blood flow (rCBF) changes of end-stage renal disease (ESRD) patients with depressive symptoms during dialysis.
  
  
  METHODS
  Fourteen patients with ESRD underwent Tc-99m ethylcysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) and were evaluated the severity of depressive mood at pre-dialytic period and at least 6 months after dialysis initiation. rCBF was analyzed using statistical parametric mapping (SPM) in brain SPECT image. The responder was defined as a decrease of ≥25% in Hamilton Depression Rating Scale (HDRS) score from baseline HDRS score.
  
  
  RESULTS
  Pre-dialysis brain SPECT did not show any rCBF differences between responders and non-responders. The follow-up brain SPECT revealed a significant higher perfusion in left middle temporal gyrus of responder group when compared with non-responder (hemisphere coordinate X, Y, Z; -58, -2, -16, peak Z = 3.36, p = 0.046). In responder, a significant increase in rCBF was found in right parahippocampal gyrus (hemisphere coordinate X, Y, Z; 30, -40, -14, peak Z = 3.51, p = 0.043). In non-responder, there were significant decreases in rCBF in left superior frontal gyrus (hemisphere coordinate X, Y, Z; -22, 30, 42, peak Z = 3.86, p = 0.032) and right orbitofrontal cortex (hemisphere coordinate X, Y, Z; 10, 58, -6, peak Z = 3.81, p = 0.046).
  
  
  CONCLUSIONS
  The present findings showed the characteristic patterns of rCBF changes in depressive ESRD patients having maintenance dialysis. Further investigations in brain blood flow and glucose metabolism are needed to elucidate the effect of dialysis itself and the difference of according to dialysis modality in patients having depression and ESRD.
authors.affiliation: Department of Nuclear Medicine, Pusan National University Hospital and Medical Research Institute, Pusan National University, Busan, Republic of Korea.
authors.forename: Hyun-Yeol
authors.initials: HY
authors.lastname: Nam
authors.forename: Sang Heon
authors.initials: SH
authors.lastname: Song
authors.forename: Seong-Jang
authors.initials: SJ
authors.lastname: Kim
authors.forename: Ihm Soo
authors.initials: IS
authors.lastname: Kwak
authors.forename: In Joo
authors.initials: IJ
authors.lastname: Kim
authors.forename: Soo Bong
authors.initials: SB
authors.lastname: Lee
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Lee
authors.forename: Bum Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Kyoungjune
authors.initials: K
authors.lastname: Pak
authors.forename: Yong-Ki
authors.initials: YK
authors.lastname: Kim
authors.forename: Hyun Sil
authors.initials: HS
authors.lastname: Yun
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D003545:Cysteine / Q000031:analogs & derivatives / Q000737:chemistry; D003866:Depressive Disorder / Q000150:complications*; D019281:Dimerization; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000737:chemistry; D006435:Renal Dialysis; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine