title: [Analysis of multifocal electroretinogram first-order kernel P(1) wave in anisometropic amblyopia].
abstract: OBJECTIVE
  To investigate the features of the multifocal electroretinogram (mfERG) first-order kernel P(1) wave in anisometropic amblyopic eyes.
  
  
  METHODS
  mfERG of fifteen anisometropic amblyopic eyes and their normal control eyes were recorded with ROLAND RETIscan visual evoked response system, the mean amplitude density and eclipse period of the P(1) wave were analyzed and compared between the amblyopic and normal eyes with t-test.
  
  
  RESULTS
  The P(1) wave amplitude density of mfERG first-order kernel in amblyopic eyes (164.7 ± 73.1) nV×deg(-2) was significantly attenuated in the central region of the visual field as compared with that of the control eyes (227.0 ± 61.3) nV×deg(-2) (t = 2.554, P = 0.016). The eclipse period of the amblyopic eyes (30.3 ± 4.3) ms was shorter than that of the control eyes (34.4 ± 3.2) ms (t = 2.92, P = 0.007).
  
  
  CONCLUSIONS
  The significant change of the multifocal electroretinogram (mfERG) first-order kernel P(1) wave may reflect the abnormality of the retinal on-bipolar cells function and the visual information transmission, whether the P(1) wave could be used as an objective index of amblyopic eyes is a promising research topic.
authors.affiliation: Department of Ophthalmology, the Third Hospital of Wuhan, 430060, China.
authors.forename: Cai-ni
authors.initials: CN
authors.lastname: Ji
authors.forename: Yin
authors.initials: Y
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Fei
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Zheng
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Zhi-tao
authors.initials: ZT
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Song
authors.forename: Tian-qin
authors.initials: TQ
authors.lastname: Song
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Gui-gang
authors.initials: GG
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000550:Amblyopia / Q000503:physiopathology*; D015858:Anisometropia / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D014792:Visual Acuity; D055815:Young Adult