title: PEG based hyperbranched polymeric hollow nanospheres.
abstract: The synthesis of a new PEG based hyperbranched copolymer of poly(ethylene glycol) methyl ether methacrylate-co-ethylene glycol dimethacrylate (PEGMEMA-co-EGDMA) was achieved via a one-step in situ deactivation enhanced atom transfer radical polymerization (DE-ATRP). Then, hollow PEG based nanospheres were fabricated from this polymer using a solvent evaporation method and post-stabilisation strategy. Furthermore, the analysis using a cellular metabolic activity assay proved that the copolymer did not affect cellular metabolism, indicating that this PEG based polymeric nanosphere has potential for use in drug delivery applications.
authors.affiliation: Network of Excellence for Functional Biomaterials, National University of Ireland, Galway, Ireland.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Cao
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Dong
authors.forename: Suzanne
authors.initials: S
authors.lastname: O'Rorke
authors.forename: Wenxin
authors.initials: W
authors.lastname: Wang
authors.forename: Abhay
authors.initials: A
authors.lastname: Pandit
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D051379:Mice; D008855:Microscopy, Electron, Scanning; D054118:Nanospheres / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D011109:Polymethacrylic Acids; C557481:poly(ethylene glycol) methyl ether methacrylate-co-ethylene glycol dimethacrylate; D011092:Polyethylene Glycols