title: Risk factors for hospital-acquired pneumonia caused by imipenem-resistant Pseudomonas aeruginosa in an intensive care unit.
abstract: Imipenem-resistant Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia. Aiming to determine the risk factors associated for hospital-acquired pneumonia due to imipenem-resistant Pseudomonas aeruginosa, we undertook a retrospective case-case-control study. Patients admitted to a 14-bed medical-surgical intensive care unit from a university-affiliated hospital with hospital-acquired pneumonia caused by imipenem-resistant Pseudomonas aeruginosa strains and by imipenem-susceptible Pseudomonas aeruginosa strains were matched to control patients by time under risk and comorbidities. A total of 58 resistant cases, 47 susceptible cases and 237 controls were evaluated. The risk factors independently associated to hospital-acquired pneumonia caused by imipenem-resistant Pseudomonas aeruginosa were: duration of hospitalisation, Acute Physiological and Chronic Health Evaluation II score, male gender receipt of haemodialysis, receipt of piperacillin-tazobactam and receipt of third-generation cephalosporins.
authors.affiliation: Division of Infectious Diseases, Federal University of São Paulo, São Paulo, Brazil. ghfurtado@uol.com.br
authors.forename: G H
authors.initials: GH
authors.lastname: Furtado
authors.forename: A C
authors.initials: AC
authors.lastname: Gales
authors.forename: L B
authors.initials: LB
authors.lastname: Perdiz
authors.forename: A E
authors.initials: AE
authors.lastname: Santos
authors.forename: S B
authors.initials: SB
authors.lastname: Wey
authors.forename: E A
authors.initials: EA
authors.lastname: Medeiros
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016022:Case-Control Studies; D003428:Cross Infection / Q000209:etiology* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000209:etiology* / Q000382:microbiology; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem