title: [Effect of anions and anion channel blockers on vascular tone in rat aorta].
abstract: OBJECTIVE
  To investigate the action of anions and anion channel blockers in the regulation of vascular contraction induced by norepinephrine (NE).
  
  
  METHODS
  NE-induced contraction was observed in rat aorta by using routine blood vascular perfusion in vitro.
  
  
  RESULTS
  The anion channel blockers niflumic acid (NFA) and 5-nitro-2-(3-phenoxylpropylamino)-benzoic acid (NPPB) produced inhibitory effects on NE-evoked contractions in the aorta. NE-induced contraction was not significantly changed after the extracellular Na+ was replaced by choline, in contrast, the vascular was relaxed when the extracellular Cl- was replaced by glutamate. Moreover, the vasoconstriction induced by NE was further enhanced with the replacement of the extracellular Cl- by Br-, which was still sensitive to either NFA or NPPB.
  
  
  CONCLUSIONS
  Anion channels play an important role in the regulation of blood vascular tone, which may be responsible for the salt-sensitivity hypertension.
authors.affiliation: Department of Physiology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Ma
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Pei
authors.forename: Yue-min
authors.initials: YM
authors.lastname: Wang
authors.forename: An-gang
authors.initials: AG
authors.lastname: Yang
authors.forename: Shi-sheng
authors.initials: SS
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000838:Anions / Q000378:metabolism; D001011:Aorta / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000037:antagonists & inhibitors*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000838:Anions; D007473:Ion Channels; D009638:Norepinephrine