title: (-)-Sclerotiorin from an unidentified marine fungus as an anti-meiotic and anti-fungal agent.
abstract: (-)-Sclerotiorin, isolated and purified from the fermented broth of an unidentified marine fungus (98F134), inhibited the maturation of starfish oocytes induced by 1-methyl adenine with an IC50 value of 0.50 microM. (-)-Sclerotiorin also showed antifungal activity against Saccharomyces cerevisiae, Aspergilus fumigatus, Alternaria longipes, Piricularia oryzae, Verticillium albo-atrum, Fusarium culmorum, and F. nivale with IC50 values less than 20 microg/mL.
authors.affiliation: Key Lab of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, 13 Beiertiao, Zhongguancun, Beijing 100080, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Xu
authors.forename: Shu-Bin
authors.initials: SB
authors.lastname: Niu
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry* / Q000187:drug effects; D008540:Meiosis / Q000187:drug effects; D015394:Molecular Structure; D009865:Oocytes / Q000187:drug effects; D013215:Starfish
chemical_list: D000935:Antifungal Agents; D001578:Benzopyrans; C101449:sclerotiorin