title: Immunotoxicity activity of natural furocoumarins from milky sap of Ficus carica L. against Aedes aegypti L.
abstract: Ficus carica L., its fruits are delicious and can be eaten by human. Its leaves are commonly used to cure hemorrhoid and clear away heart ache. The milky sap of F. carica have a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an lethal concentration (LC(50)) value of 10.2 μg/ml and an LC(90) value of 42.3 μg/ml. Two natural furocoumarins, 5-methoxypsoralen and 8-methoxypsoralen were isolated from the milky sap of F. carica. The LC(50) value of 5-methoxypsoralen and 8-methoxypsoralen were 9.4 and 56.3 μg/ml, respectively. The above indicates that major compounds may play a more important role in the toxicity of the milky sap of F. carica.
authors.affiliation: Department of Applied Life Science, Kon Kuk University, Seoul, South Korea.
authors.forename: Iii-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Sun-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Min-A
authors.initials: MA
authors.lastname: Yeo
authors.forename: Se-Won
authors.initials: SW
authors.lastname: Park
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000078223:5-Methoxypsoralen; D000330:Aedes; D000818:Animals; D030681:Ficus / Q000737:chemistry*; D011564:Furocoumarins / Q000276:immunology / Q000494:pharmacology*; D000922:Immunotoxins / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology*; D007306:Insecticides; D007814:Larva / Q000276:immunology / Q000469:parasitology; D007928:Lethal Dose 50; D008730:Methoxsalen / Q000031:analogs & derivatives / Q000276:immunology / Q000494:pharmacology; D009032:Mosquito Control / Q000379:methods; D010936:Plant Extracts / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D011564:Furocoumarins; D000922:Immunotoxins; D007306:Insecticides; D010936:Plant Extracts; D000078223:5-Methoxypsoralen; D008730:Methoxsalen