title: [Macrophage: pathogenesis in the progression of atherosclerosis].
abstract: Atherosclerotic changes in aorta or coronary arteries involve the accumulation and activation of macrophages, which this type of cell is present not only in plaques of intima but in the outer-media and adventitia. Macrophages play important roles in the progression of atherosclerosis by exhibiting unique characteristics under the various stimuli, evolving the plaque instability, thrombus formation and remodeling. Recent studies have shown the molecules-associated with metabolism, such as sirtuin-1 and peroxisome proliferator -activated receptor gamma in macrophages, appear to be involved to modulate the atherosclerotic process. In addition, macrophages work coordinately with other immune cells like mast cells. Thus, modulation of activation and function in macrophages might be a potential therapeutic target in attenuating the atherosclerosis-based cardiovascular diseases.
authors.affiliation: Department of Internal Medicine, Circulatory and Body Fluid Regulation.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tsuruda
authors.forename: Kinta
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D050197:Atherosclerosis / Q000209:etiology*; D006801:Humans; D008262:Macrophage Activation / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology; D058226:Plaque, Atherosclerotic / Q000209:etiology; D056564:Sirtuin 1 / Q000502:physiology; D013927:Thrombosis / Q000209:etiology
chemical_list: D047495:PPAR gamma; C447939:SIRT1 protein, human; D056564:Sirtuin 1