title: The effect of amiodarone on cardiac rhythm after cardiopulmonary bypass in patients with atrial fibrillation.
abstract: OBJECTIVE
  The intraoperative use of amiodarone in patients with atrial fibrillation (AF) undergoing valvular heart surgery was unclear. Hence, a randomized clinical trial was designed to evaluate the effect of amiodarone on cardiac recovery and rhythm following mitral valve surgery.
  
  
  METHODS
  A total of 120 elective mitral valve replacement patients with AF received either amiodarone (5 mg/kg) or the same volume of saline during cardiopulmonary bypass (CPB), in a randomized manner. Cardiac recovery was assessed by the heart auto re-beat ratio, the time from reperfusion to heart beat, the post-reperfusion rhythm, pacemaker use, and vasoactive drug use.
  
  
  RESULTS
  A higher heart auto re-beat ratio, higher sinus rhythm ratio, lower electric defibrillation ratio and less dopamine usage were found in the amiodarone treatment group. However, the proportion of temporary pacemaker use was lower in the control group.
  
  
  CONCLUSIONS
  Amiodarone had a good effect on cardiac recovery and the rhythm of AF patients after CPB.
authors.affiliation: Department of Anesthesiology, Jiangsu Province Hospital, Nanjing Medical University, Nanjing 210029, PR China. dgsunjie@hotmail.com
authors.forename: Sun
authors.initials: S
authors.lastname: Jie
authors.forename: Chen
authors.initials: C
authors.lastname: Yu
authors.forename: Lu
authors.initials: L
authors.lastname: Xiaohu
authors.forename: Qian
authors.initials: Q
authors.lastname: Yanning
authors.forename: Ding
authors.initials: D
authors.lastname: Zhengnian
authors.forename: Tang
authors.initials: T
authors.lastname: Xiaoyang
mesh_terms: D000638:Amiodarone / Q000008:administration & dosage*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D002681:China; D004280:Dobutamine / Q000627:therapeutic use; D017558:Elective Surgical Procedures; D004554:Electric Countershock; D006339:Heart Rate / Q000187:drug effects*; D006349:Heart Valve Diseases / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D007430:Intraoperative Care; D008943:Mitral Valve / Q000503:physiopathology / Q000601:surgery*; D020127:Recovery of Function; D013997:Time Factors; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D014662:Vasoconstrictor Agents; D004280:Dobutamine; D000638:Amiodarone