title: [Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion].
abstract: OBJECTIVE
  To study the expression of stomatin-like protein-2 (SLP-2) in esophageal squamous cell carcinoma (ESCC), and analyze the correlation between SLP-2 expression and clinicopathological features.
  
  
  METHODS
  The expression of SLP-2 protein in ESCC tissues (18 and 220 cases respectively) was detected by Western blot and IHC. The association between SLP-2 expression and clinicopathological features was analyzed.
  
  
  RESULTS
  Compared with normal epithelium, 13 cases of ESCC tissues showed a higher expression of SLP-2 on the protein level (72.2%, 13/18). IHC analysis on tissue microarray revealed that the expression rate of SLP-2 protein in ESCC was 54.1% and in normal esophageal mucosa was 3.6%, showing a significant difference (P < 0.001). SLP-2 high-level expression correlates with the extent of ESCC invasion (P = 0.033), but not with other clinicopathologic characteristics (P > 0.05).
  
  
  CONCLUSIONS
  SLP-2 as a novel cancer-related gene may play an important role in tumorigenesis of ESCC. The overexpression of SLP-2 may be closely associated with the invasion of esophageal cancer.
authors.affiliation: Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Cao
authors.forename: Li-yong
authors.initials: LY
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Yue-qi
authors.initials: YQ
authors.lastname: Wang
authors.forename: Zhi-hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Bao-cun
authors.initials: BC
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000378:metabolism* / Q000502:physiology; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D008875:Middle Aged; D009361:Neoplasm Invasiveness
chemical_list: D001798:Blood Proteins; D008565:Membrane Proteins; C406287:STOML2 protein, human