title: Localization of antimicrobial peptides on polymerized liposomes leading to their enhanced efficacy against Pseudomonas aeruginosa.
abstract: Antimicrobial peptide IG-25 (a truncated version of LL-37 of the cathelicidin family) tethering an azido-capped poly(ethylene glycol) chain at the N-terminus was site-specifically attached to alkynyl-terminated polymerized liposomes using copper catalyzed "click" reaction, leading to an 18 fold enhancement in efficacy against Pseudomonas aeruginosa when compared to LL-37 without any increase in cytotoxicity to human corneal epithelial cells.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Satya S
authors.initials: SS
authors.lastname: Kolar
authors.forename: Meriong
authors.initials: M
authors.lastname: Zao
authors.forename: Alison M
authors.initials: AM
authors.lastname: McDermott
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Cai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D003315:Cornea / Q000166:cytology / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013329:Structure-Activity Relationship; D054804:Cathelicidins
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C556980:I-G-K-E-F-K-R-I-V-Q-R-I-K-D-F-L-R-N-L-V-P-R-T-E-S; D008081:Liposomes; D011092:Polyethylene Glycols; D003300:Copper; D054804:Cathelicidins