title: TAR-DNA binding protein-43 and alterations in the hippocampus.
abstract: Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and α-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.
authors.affiliation: Department of Pathology, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Tuomas
authors.initials: T
authors.lastname: Rauramaa
authors.forename: Maria
authors.initials: M
authors.lastname: Pikkarainen
authors.forename: Elisabet
authors.initials: E
authors.lastname: Englund
authors.forename: Paul G
authors.initials: PG
authors.lastname: Ince
authors.forename: Kurt
authors.initials: K
authors.lastname: Jellinger
authors.forename: Anders
authors.initials: A
authors.lastname: Paetau
authors.forename: Irina
authors.initials: I
authors.lastname: Alafuzoff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D016009:Chi-Square Distribution; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014652:Vascular Diseases / Q000150:complications / Q000473:pathology; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D051844:alpha-Synuclein