title: Treatment outcome and mortality among patients with multidrug-resistant tuberculosis in tuberculosis hospitals of the public sector.
abstract: This study was conducted to evaluate treatment outcome, mortality, and predictors of both in patients with multidrug-resistant tuberculosis (MDR-TB) at 3 TB referral hospitals in the public sector of Korea. We included MDR-TB patients treated at 3 TB referral hospitals in 2004 and reviewed retrospectively their medical records and mortality data. Of 202 MDR-TB patients, 75 (37.1%) had treatment success and 127 (62.9%) poor outcomes. Default rate was high (37.1%, 75/202), comprising 59.1% of poor outcomes. Male sex (adjusted odds ratio [aOR], 2.91; 95% confidence interval [CI], 1.13-7.49), positive smear at treatment initiation (aOR, 5.50; 95% CI, 1.22-24.90), and extensively drug-resistant TB (aOR, 10.72; 95% CI, 1.23-93.64) were independent predictors of poor outcome. The all-cause mortality rate was 31.2% (63/202) during the 3-4 yr after treatment initiation. In conclusion, the treatment outcomes of patients with MDR-TB at the 3 TB hospitals are poor, which may reflect the current status of MDR-TB in the public sector of Korea. A more comprehensive program against MDR-TB needs to be integrated into the National Tuberculosis Program of Korea.
authors.affiliation: Clinical Research Center, National Masan Tuberculosis Hospital, Masan, Korea.
authors.forename: Doo Soo
authors.initials: DS
authors.lastname: Jeon
authors.forename: Dong Ok
authors.initials: DO
authors.lastname: Shin
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Seo
authors.forename: Hae Sook
authors.initials: HS
authors.lastname: Seo
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Cho
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Dae Yun
authors.initials: DY
authors.lastname: Kim
authors.forename: Suck Jun
authors.initials: SJ
authors.lastname: Kong
authors.forename: Yun Seong
authors.initials: YS
authors.lastname: Kim
authors.forename: Tae Sun
authors.initials: TS
authors.lastname: Shim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use*; D003710:Demography; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D005260:Female; D006763:Hospitals, Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012737:Sex Factors; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000401:mortality*
chemical_list: D000995:Antitubercular Agents