title: Three steroids with unique structural feature of 5β-Spirostan-1β,3β,17α-trihydroxyl from Reineckia carnea.
abstract: A new spirostanol sapogenin and two spirostanol saponins, tentatively named reineckiagenin A (1), reineckiagenoside A (2), and reineckiagenoside B (3), were isolated from the whole plant of Reineckia carnea. By detailed analysis of their 1D and 2D NMR spectra, chemical methods, and by comparison with spectra data of known compounds, the structures of the new steroids were determined to be 25(S)-5β-spirostan-1β,3β,17α-triol (1), 25(S)-5β-spirostan-1β,3β,17α-triol 1-O-β-D-xylopyranoside (2), 25(S)-5β-spirostan-1β,3β,17α-triol 1-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside (3). Compounds 1, 2, and 3 are the first naturally occurring steroids with unique structural feature of 5β-spirostan-1β,3β,17α-trihydroxyl.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.
authors.forename: Zhong-Quan
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Jian-Chao
authors.initials: JC
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Yan
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Qiu
mesh_terms: D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D013256:Steroids; C557628:reineckiagenin A; C557627:reineckiagenoside A; C557626:reineckiagenoside B