title: Palladium-catalyzed highly regio- and stereoselective synthesis of (1E)- or (1Z)-1,2-dihalo-1,4-dienes via haloallylation of alkynyl halides.
abstract: A highly efficient and selective synthesis of (1E)- or (1Z)-1,2-dihalo-1,4-dienes via Pd-catalyzed coupling of haloalkynes and allylic halides is described. The (1E)-1,2-dihalo-1,4-dienes were generated in good yields with excellent stereoselectivities (1E/1Z up to >98/2), while (1Z)-1,2-dihalo-1,4-dienes were produced in excellent yields and stereoselectivities (1Z/1E up to >98/2) by simply adding stoichiometric lithium halides.
authors.affiliation: Department of Chemistry, Zhejiang Normal University, 688 Yingbing Road, Jinhua 321004, PR China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Kong
authors.forename: Haiting
authors.initials: H
authors.lastname: Cai
authors.forename: Lichun
authors.initials: L
authors.lastname: Kong
authors.forename: Gangguo
authors.initials: G
authors.lastname: Zhu