title: Ganglioneuroma in the urinary bladder of a dog.
abstract: An 11-year-old male Labrador retriever presented with chronic oliguria. Ultrasonography findings revealed a protruding mass at the neck of the urinary bladder. A cystotomy was performed, and the mass was removed by ligation with surgical sutures. Histopathological examination revealed conspicuous foci with a variable number of ganglion cells in the tumor and abundant interwoven bundles of schwannian cells with fine fibers. The ganglion cells were positive for neuron-specific enolase and neurofilament. The schwannian cells were positive for vimentin, S-100 protein, and glial fibrillary acidic protein. Thus, according to the classification of tumor with neuronal cell differentiation, the urinary tumor was diagnosed as a ganglioneuroma.
authors.affiliation: Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu 501–1193, Japan. shiroki@gifu-u.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sakai
authors.forename: Kayoko
authors.initials: K
authors.lastname: Yonemaru
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takeda
authors.forename: Kenta
authors.initials: K
authors.lastname: Niimi
authors.forename: Mami
authors.initials: M
authors.lastname: Murakami
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hirata
authors.forename: Tokuma
authors.initials: T
authors.lastname: Yanai
mesh_terms: D000818:Animals; D053715:Cystotomy / Q000662:veterinary; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D005729:Ganglioneuroma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000662:veterinary*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D007382:Intermediate Filaments / Q000378:metabolism; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014746:Vimentin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin; D010751:Phosphopyruvate Hydratase