title: The clinical significance of coagulation and the inflammatory response in autoimmunity.
abstract: Maintenance of normal blood flow requires equilibrium between procoagulant and anticoagulant factors; occasionally, procoagulant activity predominates, leading to clot formation; frequently, tissue damage is the triggering factor. Hereditary factors, primary or acquired, play a role in the development of thrombosis. Primary thrombophilia is associated with hereditary factors, which promote hypercoagulability because natural anticoagulants are not exerting their activity. On the other hand, acquired thrombophilia may occur associated to autoimmune diseases, cancer, surgical procedures, pregnancy, postpartum period, and obesity. Activation of the coagulation system is characterized by the co-participation of inflammatory response components, factors related to the subjacent disease, and other procoagulant factors. The study of patients with thrombosis should include both inflammatory and autoimmune response markers.
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, UMAE HE CMNO IMSS, Guadalajara, Jalisco, México.
authors.forename: Benjamín
authors.initials: B
authors.lastname: Rubio-Jurado
authors.forename: Paulina
authors.initials: P
authors.lastname: Iñiguez-Franco
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Reyes
authors.forename: Gustavo
authors.initials: G
authors.lastname: Robles
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Páramo
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Zavala-Cerna
authors.forename: Carlos
authors.initials: C
authors.lastname: Riebeling
authors.forename: Arnulfo
authors.initials: A
authors.lastname: Nava
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D015551:Autoimmunity; D001777:Blood Coagulation / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology; D015956:Factor XIIa / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology*; D013917:Thrombin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood* / Q000209:etiology / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D018836:Inflammation Mediators; D015956:Factor XIIa; D013917:Thrombin