title: Diastereo- and enantioselective synthesis of oxazine and oxazolidine derivatives with a chiral quaternary carbon center under multifunctional catalysis.
abstract: An easy one-pot, multistep cascade reaction which could afford a series of substituted benzo[d]pyrido[2,1-b]oxazolidine and [1,3]oxazine derivatives in a highly enantio- (up to 98% ee) and diastereoselective (4:1 to >20:1 dr) manner with generally good to excellent yields (up to 99%) has been developed. This well designed strategy could be applied to a wide scope of substrates under mild conditions with simple operations.
authors.affiliation: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Jin
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Huicai
authors.initials: H
authors.lastname: Huang
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
authors.forename: Jinxing
authors.initials: J
authors.lastname: Ye
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010078:Oxazines; D010080:Oxazoles; C064210:oxazolidine