title: [Patient safety indicators for medication safety (AMTS-PSI): international status, transferability and validation].
abstract: BACKGROUND
  The aim of this project was to identify international patient safety indicators used for medication safety (AMTS-PSI), to evaluate the validity by a panel of experts, and to examine the transfer of the international AMTS-PSI to the pharmacotherapy care of the German Health Care System. It was part of the "Agenda for the Improvement of Medication Safety 2008/2009 in Germany" of the German Ministry of Health.
  
  
  METHODS
  National and international AMTS-PSI were identified by a systematic review (Set 1). To define patient safety indicators as a subdivision of quality indicators, the indicators were categorised by patient's risk of adverse drug events and the degree of prevention (Set 2). Duplicates of AMTS-PSI were excluded (Set 3). The content validity was determined by the "qualify-instrument" on categories "relevance", "evidence" and "feasibility". This process was based on a double-stage Delphi method. The transferability to the pharmacotherapy care of the German Health Care System of the AMTS-PSI was evaluated (Set 4).
  
  
  RESULTS
  385 AMTS-indicators were identified. The categorisation resulted in a set of 40 AMTS-PSI, 20 AMTS-PSI were excluded. The evaluation of the validity by the "qualify-instrument" and the transferability resulted in a set of 14 for the stationary, ambulant sector. They also were valid for both sectors.
  
  
  CONCLUSIONS
  An AMTS-PSI-set was identified by a systematic review and recognised as valid for transferring it to the pharmacotherapy care of the German Health Care System by the "qualify-instrument". These 14 AMTS-PSI are mainly characterised by their relevance. Before using these indicators in practice, their further operationalisation seems necessary.
authors.affiliation: Institut für Patientensicherheit der Rheinischen Friedrich-Wilhelms-Universität Bonn, Bonn.
authors.forename: S
authors.initials: S
authors.lastname: Kuske
authors.forename: C
authors.initials: C
authors.lastname: Lessing
authors.forename: R
authors.initials: R
authors.lastname: Lux
authors.forename: A
authors.initials: A
authors.lastname: Schmitz
authors.forename: M
authors.initials: M
authors.lastname: Schrappe
mesh_terms: D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D003697:Delphi Technique; D064420:Drug-Related Side Effects and Adverse Reactions / Q000401:mortality* / Q000517:prevention & control; D005858:Germany; D006801:Humans; D009313:National Health Programs / Q000592:standards*; D061214:Patient Safety / Q000592:standards*; D058996:Quality Improvement / Q000592:standards; D019984:Quality Indicators, Health Care / Q000592:standards*; D018570:Risk Assessment / Q000592:standards