title: Homozygosity for the Ala allele of the PPARγ2 Pro12Ala polymorphism is associated with reduced risk of coronary artery disease.
abstract: Several studies suggest that the peroxisome proliferator-activated receptor gamma (PPARγ) is involved in atherogenesis. The Pro12Ala polymorphism in the gene encoding PPARγ (PPARγ2 gene) influences the risk for type 2 diabetes. Two population-based studies have shown that the Ala allele is associated with reduced carotid intimal-medial thickness (IMT). However, studies focusing on acute clinical events have yielded conflicting results. Our aim was to evaluate the role of the Pro12Ala PPARγ2 polymorphism on the risk of coronary artery disease (CAD) in an Italian population with a case-controlled genetic association study in which 478 CAD patients and 218 controls were genotyped for the Pro12Ala polymorphism. CAD was diagnosed by angiography. We found that homozygotes for the Ala12 allele had a significantly reduced risk of CAD after adjusting for diabetes, sex, age, body mass index (BMI), smoking, lipids and hypertension (OR =0.007; 95% C.I. = 0.00-0.32 p< 0.011). In this case-control study, homozygosity for the Ala allele at codon 12 of the PPARγ2 gene resulted in reduced risk of CAD. This is consistent with reports from previous studies focusing on atherosclerosis and myocardial infarction.
authors.affiliation: Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy. galgani@scienze.uniroma2.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Galgani
authors.forename: AnaMaria
authors.initials: A
authors.lastname: Valdes
authors.forename: Henry A
authors.initials: HA
authors.lastname: Erlich
authors.forename: Calvin
authors.initials: C
authors.lastname: Mano
authors.forename: Suzanne
authors.initials: S
authors.lastname: Cheng
authors.forename: Antonio
authors.initials: A
authors.lastname: Petrone
authors.forename: Federica
authors.initials: F
authors.lastname: Sentinelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Berni
authors.forename: Marco G
authors.initials: MG
authors.lastname: Baroni
authors.forename: Raffaella
authors.initials: R
authors.lastname: Buzzetti
mesh_terms: D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D016037:Single-Blind Method
chemical_list: D005819:Genetic Markers; D047495:PPAR gamma