title: Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.
abstract: OBJECTIVE
  We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations.
  
  
  METHODS
  A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set.
  
  
  RESULTS
  Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10(-7)) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population.
  
  
  CONCLUSIONS
  BTN2A1 may be a susceptibility gene for MI in Japanese individuals.
authors.affiliation: Life Science Research Center, Mie University, Tsu, Japan. yamada@gene.mie-u.ac.jp
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Yamada
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Nishida
authors.forename: Sahoko
authors.initials: S
authors.lastname: Ichihara
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Fuku
authors.forename: Yutaka
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authors.lastname: Nishigaki
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Aoyagi
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yoshida
authors.forename: Shoji
authors.initials: S
authors.lastname: Shinkai
authors.forename: Kei
authors.initials: K
authors.lastname: Satoh
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kato
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yokoi
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Oguri
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Sachiro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Aki
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Kojima
authors.forename: Bok-Ghee
authors.initials: BG
authors.lastname: Han
authors.forename: Younjin
authors.initials: Y
authors.lastname: Ahn
authors.forename: Meehee
authors.initials: M
authors.lastname: Lee
authors.forename: Dong-Jik
authors.initials: DJ
authors.lastname: Shin
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D000071797:Butyrophilins; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007723:Korea / Q000453:epidemiology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D000071797:Butyrophilins; D008562:Membrane Glycoproteins