title: Descemet's stripping with endothelial keratoplasty for special Fuchs' endothelial dystrophy in phakic eyes.
abstract: BACKGROUND
  To determine the efficacy and postoperative complications of simple Descemet's stripping endothelial keratoplasty (DSEK) for treatment of special Fuchs' endothelial dystrophy in phakic eyes.
  
  
  METHODS
  Six eyes with clear crystalline lenses in 5 consecutive patients with Fuchs' endothelial dystrophy underwent DSEK and were followed up for 12-27 months. The pupil was constricted preoperatively to 1.5 mm in diameter. The anterior chamber was deepened intraoperatively by injection of balanced salt solution to unfold the donor graft and to protect the crystalline lens. Best corrected visual acuity, corneal astigmatism, corneal curvature, corneal thickness, and anterior chamber depth were recorded preoperatively and at 6 and 12 months postoperatively. Average endothelial cell density and endothelial cell loss (ECL) were recorded at 6 and 12 months postoperatively.
  
  
  RESULTS
  DSEK was successfully performed in all 6 eyes. No graft dislocation or lens injury occurred. One of the 6 eyes presented with mild cataract at 12 months after surgery but showed no sign of progressive cataract development during the follow-up. All grafts were clear during the last follow-up: best corrected visual acuity ranged from 20/50 to 20/30, average corneal astigmatism was 2.2 ± 0.6 dpt, average corneal curvature was 46.0 ± 2.4 dpt, and average central corneal thickness was 583.0 ± 21.5 μm. At 6 and 12 months postoperatively, average endothelial cell density was 2,070.7 ± 206.1 cells/mm(2) (28.0 ± 7.5% of ECL) and 1,838.3 ± 194.5 cells/mm(2) (36.1 ± 6.2% of ECL), respectively.
  
  
  CONCLUSIONS
  Simple DSEK might be a feasible option for Fuchs' endothelial dystrophy in young patients with clear crystalline lenses.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, PR China.
authors.forename: Ting
authors.initials: T
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Andina
authors.initials: A
authors.lastname: Hu
authors.forename: Na
authors.initials: N
authors.lastname: Gao
mesh_terms: D000328:Adult; D002452:Cell Count; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis; D057111:Descemet Stripping Endothelial Keratoplasty; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005642:Fuchs' Endothelial Dystrophy / Q000601:surgery*; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D014019:Tissue Donors; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult