title: The autoantigen Pso p27: a post-translational modification of SCCA molecules.
abstract: Pso p27 is a protein antigen expressed in psoriatic lesions and is shown to participate in complement activating immune complexes in the affected skin. The objective of the present study was sequencing of the Pso p27 protein in an approach to identify a "Pso p27 gene". The analyses showed that Pso p27 represents several proteins with homologies to various Squamous Cell Carcinoma Antigens (SCCAs). The unique N-terminal and C-terminal ends of Pso p27, however, differ from the terminal ends of the SCCA molecules and indicate posttranslational digestions of SCCA molecules with highly specific endoproteases. These structural variations may play crucial roles with respect to the immunogenicity of Pso p27 and the failure of immunological tolerance.
authors.affiliation: Department of Laboratory Medicine Children's and Women's Health and Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. oleji@ntnu.no
authors.forename: Ole-Jan
authors.initials: OJ
authors.lastname: Iversen
authors.forename: Hilde
authors.initials: H
authors.lastname: Lysvand
authors.forename: Lars
authors.initials: L
authors.lastname: Hagen
mesh_terms: D000595:Amino Acid Sequence; D000941:Antigens / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D000951:Antigens, Neoplasm / Q000276:immunology*; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology; D015843:Serpins / Q000276:immunology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D001324:Autoantigens; D015843:Serpins; C097643:antigen pso p27; C051072:squamous cell carcinoma-related antigen