title: Differential pulse voltammetric simultaneous determination of acetaminophen and ascorbic acid using single-walled carbon nanotube-modified carbon-ceramic electrode.
abstract: Single-walled carbon nanotube-modified carbon-ceramic electrode (SWCNT/CCE) was employed for the simultaneous determination of acetaminophen (APAP) and ascorbic acid (AA). The SWCNT/CCE displayed excellent electrochemical catalytic activities toward APAP and AA oxidation compared with bare CCE. In the differential pulse voltammetry technique, both AA and APAP gave sensitive oxidation peaks at -62 and 302 mV versus saturated calomel electrode, respectively. Under the optimized experimental conditions, APAP and AA gave linear responses over ranges of 0.2 to 150.0 μM (R(2)=0.998) and 5.0 to 700.0 μM (R(2)=0.992), respectively. The lower detection limits were found to be 0.12 μM for APAP and 3.0 μM for AA. The investigated method showed good stability, reproducibility, and repeatability as well as high recovery in pharmaceutical and biological samples.
authors.affiliation: Electroanalytical Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran. b.habibi@azaruniv.edu
authors.forename: Biuck
authors.initials: B
authors.lastname: Habibi
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Jahanbakhshi
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Pournaghi-Azar
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000097:blood; D001205:Ascorbic Acid / Q000032:analysis* / Q000097:blood; D002384:Catalysis; D002516:Ceramics / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry; D015203:Reproducibility of Results
chemical_list: D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D001205:Ascorbic Acid