title: A clinical study comparing oral formulations containing 7.5% calcium sodium phosphosilicate (NovaMin), 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity.
abstract: To determine and compare the clinical performance of formulations containing 7.5% calcium sodium phosphosilicate (NovaMin), 5% potassium nitrate, and 0.4% stannous fluoride for the management of dentin hypersensitivity.
  
  
  METHODS
  This was a single-center, randomized, double-blind, parallel-group design with a duration of 12 weeks. The study included a total of 120 subjects and measured sensitivity to cold water and air blast by the use of a visual analogue scale. Measurements were taken at baseline, two, four, and 12 weeks.
  
  
  RESULTS
  All three products significantly reduced sensitivity versus baseline at each time point, although the calcium sodium phosphosilicate (NovaMin) dentifrice reduced sensitivity significantly more than the others at the two- and four-week time points. At the two-week time point, for air and water, respectively, the dentifrice containing NovaMin reduced sensitivity 45% and 49%, the stannous fluoride gel 30% and 26%, and the potassium nitrate dentifrice 35% and 34%. At the 12-week time point, the dentifrice containing NovaMin reduced sensitivity 87% and 91%, stannous fluoride gel 87% and 85%, and potassium nitrate dentifrice 84% and 79%.
  
  
  CONCLUSIONS
  In this study, all three products were effective. Compared to the potassium nitrate and stannous fluoride formulations, the dentifrice containing NovaMin provided more substantial and significant improvements at the early time points.
authors.affiliation: Armed Forces Medical Center, Pune, India.
authors.forename: Neeru
authors.initials: N
authors.lastname: Sharma
authors.forename: Subrata
authors.initials: S
authors.lastname: Roy
authors.forename: Ajay
authors.initials: A
authors.lastname: Kakar
authors.forename: David C
authors.initials: DC
authors.lastname: Greenspan
authors.forename: Randy
authors.initials: R
authors.lastname: Scott
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003802:Dentifrices / Q000627:therapeutic use*; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005898:Glass; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D010147:Pain Measurement; D017680:Potassium Compounds / Q000627:therapeutic use; D017640:Silicates / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D014002:Tin Fluorides / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D003802:Dentifrices; D057133:Dentin Desensitizing Agents; D009566:Nitrates; C510984:NovaMin; D017680:Potassium Compounds; D017640:Silicates; D014002:Tin Fluorides; C023844:potassium nitrate