title: [Clinicopathologic study of 7 cases of gastric T-cell lymphoma].
abstract: OBJECTIVE
  To study the clinicopathologic characteristics of gastric T-cell lymphoma.
  
  
  METHODS
  The clinicopathologic features of 7 cases of gastric T-cell lymphoma were retrospectively reviewed. Immunohistochemical study, T-cell receptor gene rearrangement analysis and evaluation of Epstein Barr virus (EBV) status were also performed.
  
  
  RESULTS
  The median age at onset of gastric T-cell lymphoma was 45 years. The male-to-female ratio was 6 to 1. The clinical information was available in 6 cases; and one of them had history of persistent diarrhea and 5 had hypoproteinemia. Histologically, 5 cases consisted of large lymphoma cells and the remaining 2 cases showed mainly medium-sized cells. Intraepithelial lymphoma cell infiltration was found in one case. The lymphoma cells of all cases were negative for CD20 and CD79a. CD3 and TIA-1 expression was noted in 6 of the 7 cases. CD5, βF-1 and CD30 were positive in 4 cases and CD4 was positive in 3 cases. In-situ hybridization for Epstein-Barr virus-encoded RNA was negative. Clonal T-cell receptor gene rearrangement was demonstrated in all cases.
  
  
  CONCLUSIONS
  Gastric T-cell lymphoma is a rare type of malignant lymphoma, with distinctive clinicopathologic characteristics.
authors.affiliation: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Lu
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Luo
authors.forename: Qing
authors.initials: Q
authors.lastname: Ling
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D017252:CD3 Complex / Q000378:metabolism; D018956:CD5 Antigens / Q000378:metabolism; D019002:CD56 Antigen / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D025261:Mitochondrial Proton-Translocating ATPases / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D055815:Young Adult
chemical_list: C506526:ATP5F1B protein, human; D017252:CD3 Complex; D018956:CD5 Antigens; D019002:CD56 Antigen; D016827:CD8 Antigens; D017730:Ki-1 Antigen; D016601:RNA-Binding Proteins; C076751:TIAL1 protein, human; D025261:Mitochondrial Proton-Translocating ATPases