title: Considerations for uniform and accurate biospecimen labelling in a biorepository and research environment.
abstract: Correct labelling of specimens in a biorepository or research laboratory is vital, especially for translational or clinical studies linking clinical data with biospecimens. While patient privacy must be carefully protected, confusing or inadequate labelling can potentially result in the study of the wrong biospecimens with detrimental effects to the accuracy of published findings or a requirement for invaluable biospecimens to be discarded. Labelling guidelines are described in the biorepository of the University of California-Los Angeles Brain Tumour Translational Resource, and in recipient neuro-oncology laboratories to which biospecimens and derivatives are provided. This approach includes specifying identifier types, types of dates and institutions on the biospecimen labels; using multiple identifiers on each specimen when feasible; and developing a three to four-letter alphanumeric code to aid in label recognition. In addition, steps are being taken to educate recipient laboratories on best practices in labelling.
authors.affiliation: Brain Tumor Translational Resource, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Kay
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Estrada
authors.forename: Sergey
authors.initials: S
authors.lastname: Mareninov
authors.forename: Steven S
authors.initials: SS
authors.lastname: Silver
authors.forename: Clara E
authors.initials: CE
authors.lastname: Magyar
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dry
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Cloughesy
authors.forename: William H
authors.initials: WH
authors.lastname: Yong
mesh_terms: D035843:Biomedical Research / Q000379:methods / Q000592:standards; D006801:Humans; D013048:Specimen Handling / Q000379:methods* / Q000592:standards; D014015:Tissue Banks / Q000592:standards*