title: Evidence of human papillomavirus in the placenta.
abstract: Human papillomavirus (HPV) is an epitheliotropic virus typically infecting keratinocytes but also possibly epithelial trophoblastic placental cells. In the present study, we set out to investigate whether HPV can be recovered from transabdominally obtained placental cells to avoid any confounding contamination by HPV-infected cervical cells. Thirty-five placental samples from women undergoing transabdominal chorionic villous sampling were analyzed, and we detected HPV-16 and HPV-62 in 2 placentas. This study suggests that HPV infection of the placenta can occur early in pregnancy. The overall clinical implication of these results remains to be elucidated.
authors.affiliation: Unit of Microbiology, Institute of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Weyn
authors.forename: Dominique
authors.initials: D
authors.lastname: Thomas
authors.forename: Jacques
authors.initials: J
authors.lastname: Jani
authors.forename: Meriem
authors.initials: M
authors.lastname: Guizani
authors.forename: Cathérine
authors.initials: C
authors.lastname: Donner
authors.forename: Michel
authors.initials: M
authors.lastname: Van Rysselberge
authors.forename: Christine
authors.initials: C
authors.lastname: Hans
authors.forename: Michel
authors.initials: M
authors.lastname: Bossens
authors.forename: Yvon
authors.initials: Y
authors.lastname: Englert
authors.forename: Véronique
authors.initials: V
authors.lastname: Fontaine
mesh_terms: D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D010920:Placenta / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology
chemical_list: D004279:DNA, Viral