title: Synthesis and antiviral evaluation of bisnoradamantane sulfites and related compounds.
abstract: The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.
authors.affiliation: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institute of Biomedicine, Universitat de Barcelona, Av. Diagonal, 643, 08028 Barcelona, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Valverde
authors.forename: Eva
authors.initials: E
authors.lastname: Torres
authors.forename: Salvador
authors.initials: S
authors.lastname: Guardiola
authors.forename: Lieve
authors.initials: L
authors.lastname: Naesens
authors.forename: Santiago
authors.initials: S
authors.lastname: Vázquez
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013447:Sulfites / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014780:Viruses / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D013447:Sulfites; D000218:Adamantane