title: Analysis of differences between physiological and pathological tremor of human fingers.
abstract: The study tried to reveal the differences between physiological and pathological tremor appearing during maintenance of isometric force in healthy individual and parkinsonian patients with tremor. Six-level wavelet expansion was used presenting the tremor as a sum of smoothed (slow) component and high-frequency detailed components of 6 expansion levels. The differences in the high-frequency components were assessed by calculating the energetic parameters in the power spectrum of these components. These parameters make it possible not only to reliably distinguish the energetic spectra of the detail components of the physiological and pathological tremor, but also to correlate changes in patient state caused by drug treatment of parkinsonian trembling with the decrease in these parameters.
authors.affiliation: I P Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. glarov.holo@mail.ioffe.ru
authors.forename: O E
authors.initials: OE
authors.lastname: Dick
authors.forename: S P
authors.initials: SP
authors.lastname: Romanov
authors.forename: A D
authors.initials: AD
authors.lastname: Nozdrachev
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001545:Benserazide / Q000627:therapeutic use; D004338:Drug Combinations; D004576:Electromyography; D005385:Fingers / Q000502:physiology*; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D014202:Tremor / Q000503:physiopathology*
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; C005177:benserazide, levodopa drug combination; D007980:Levodopa; D001545:Benserazide