title: Reproducibility of subregional trabecular bone micro-architectural measures derived from 7-Tesla magnetic resonance images.
abstract: High-resolution magnetic resonance imaging (MRI) of trabecular bone combined with quantitative image analysis represents a powerful technique to gain insight into trabecular bone micro-architectural derangements in osteoporosis and osteoarthritis. The increased signal-to-noise ratio of ultra high-field MR (≥7 Tesla) permits images to be obtained with higher resolution and/or decreased scan time compared to scanning at 1.5/3T. In this small feasibility study, we show high measurement precision for subregional trabecular bone micro-architectural analysis performed on 7T knee MR images. The results provide further support for the use of trabecular bone measures as biomarkers in clinical studies of bone disorders.
authors.affiliation: Center for Biomedical Imaging, Department of Radiology, 660 First Avenue, 4th Floor, NYU Langone Medical Center, New York, NY 10016, USA. gregory.chang@nyumc.org
authors.forename: Gregory
authors.initials: G
authors.lastname: Chang
authors.forename: Ligong
authors.initials: L
authors.lastname: Wang
authors.forename: Guoyuan
authors.initials: G
authors.lastname: Liang
authors.forename: James S
authors.initials: JS
authors.lastname: Babb
authors.forename: Punam K
authors.initials: PK
authors.lastname: Saha
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
mesh_terms: D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000166:cytology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D007394:International System of Units; D007717:Knee / Q000473:pathology*; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010024:Osteoporosis / Q000473:pathology; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods; D014894:Weights and Measures