title: Benign methodology and improved synthesis of 5-(2-chloroquinolin-3-yl)-3-phenyl-4,5-dihydroisoxazoline using acetic acid aqueous solution under ultrasound irradiation.
abstract: In the present paper, we have executed the synthesis of substituted 5-(2-chloroquinolin-3-yl)-3-phenyl-4,5-dihydroisoxazolines via the reactions of substituted 3-(2-chloroquinolin-3-yl)-1-phenylprop-2-en-1-ones with hydroxylamine hydrochloride and sodium acetate in aqueous acetic acid solution in 72-90% yields at room temperature under ultrasound irradiation. This method provides several advantages such as operational simplicity, higher yield, safety and environment friendly protocol. The resulting substituted isoxazolines were characterized on the basis of (1)H NMR, (13)C NMR, IR, elemental analysis, and mass spectral data.
authors.affiliation: Department of Chemistry, Rashtasant Tukadoji Maharaj, Nagpur University, Nagpur, India. vandanachemie@gmail.com
authors.forename: Vandana
authors.initials: V
authors.lastname: Tiwari
authors.forename: Ali
authors.initials: A
authors.lastname: Parvez
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Meshram
mesh_terms: D019342:Acetic Acid / Q000737:chemistry* / Q000528:radiation effects*; D002739:Chloroquinolinols / Q000138:chemical synthesis* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*; D014867:Water / Q000737:chemistry*
chemical_list: D002739:Chloroquinolinols; D014867:Water; D019342:Acetic Acid