title: [Role of surgical resection for scirrhous gastric cancer with minimal peritoneal metastasis].
abstract: Prognosis of scirrhous gastric cancer with minimal peritoneal metastasis was poor, and the role of resection has not been clarified yet. Analysis 1: Overall survival was examined in 79 patients who underwent R0/R1 resection during 1970-1995 at Kanagawa Cancer Center (Group A), and in 47 patients who underwent R0/R1 resection and received S1 chemotherapy at the 30 hospitals of Japan Clinical Oncology Group (Group B). Hazard ratio (HR) of group B to group A was examined. HR was 0.64 at 1 year, 0.76 at 2-year, and 0.92 at 3-year. Analysis 2: HR of S1 group in SPIRITS phase III trial to FU group in JCOG 9205 phase III trial was examined. HR was 0.64 at 1 year and 0.84 at 2-year. Analysis 3: HR was compared each other including HR of ACTS-GC phase III trial. HR was ACTS<analysis 1=analysis 2 at 1 year, and was ACTS<analysis 1<analysis 2 at 2-year. In conclusion, these results suggested that the significance of resection increased by post-operative S1 chemotherapy.
authors.affiliation: Dept. of Gastrointestinal Surgery, Kanagawa Cancer Center.
authors.forename: Takaki
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Toru
authors.initials: T
authors.lastname: Aoyama
authors.forename: Takafumi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogata
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Cho
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuburaya
authors.forename: Osamu
authors.initials: O
authors.lastname: Kobayashi
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D010534:Peritoneal Neoplasms / Q000556:secondary*; D016016:Proportional Hazards Models; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*