title: The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance.
abstract: BACKGROUND
  The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories.
  
  
  METHODS
  Data from six population-based prospective studies in Finland and Sweden, with 4818 men and 4269 women aged 25-89 years who were free of CHD and without a prior history of diabetes at baseline, were jointly analysed. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD incidence were estimated.
  
  
  RESULTS
  457 participants developed CHD during follow-up of 10 years. The multivariate adjusted HRs (95% CIs) for CHD incidence were 1.39 (1.08-1.80), 0.57 (0.39-0.84), 1.21 (1.07-1.37), 1.56 (1.21-2.01) and 1.74 (1.34-2.26), respectively, corresponding to a one unit increase in Z-scores of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C and TC to HDL ratio, in people with newly diagnosed diabetes. The prediction was also significant in non-diabetic population except for TG in individuals with normoglycaemia and TG and HDL-C in those with isolated IFG.
  
  
  CONCLUSIONS
  Adverse lipid profiles were related to increased CHD incidence in normoglycaemic, fasting hyperglycaemic and diabetic individuals, but not in people with IGT. The findings may imply considering different management strategies in people with fasting or post-load hyperglycaemia.
authors.affiliation: Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland. lei.zhang@thl.fi,
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Qiao
authors.forename: Tiina
authors.initials: T
authors.lastname: Laatikainen
authors.forename: Stefan
authors.initials: S
authors.lastname: Söderberg
authors.forename: Pekka
authors.initials: P
authors.lastname: Jousilahti
authors.forename: Altan
authors.initials: A
authors.lastname: Onat
authors.forename: Peter
authors.initials: P
authors.lastname: Nilsson
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis*; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology*; D050171:Dyslipidemias / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013548:Sweden / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D008055:Lipids