title: Low-grade myofibroblastic sarcoma of the larynx.
abstract: Low-grade myofibroblastic sarcoma is an uncommon sarcoma with myofibroblastic differentiation. It occurs in a wide variety of sites and has a predilection for the head and neck region. Biologically, low-grade myofibroblastic sarcoma has a propensity for local recurrence and is associated with a low risk of metastatic spread. Histologically, it can mimic a variety of different types of benign and malignant processes and often requires immunohistochemical analysis for its accurate identification. This report describes a case and discusses the differential diagnosis of a low-grade myofibroblastic sarcoma that arose in the larynx of a 69-year-old woman with a history of metastatic skin melanoma. To the best of the authors' knowledge this is the first description in the English literature of low-grade myofibroblastic sarcoma originating in the larynx.
authors.affiliation: National Cancer Institute Regina Elena, Rome, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Covello
authors.forename: Stefano
authors.initials: S
authors.lastname: Licci
authors.forename: Barbara
authors.initials: B
authors.lastname: Pichi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Spriano
authors.forename: Antonello
authors.initials: A
authors.lastname: Vidiri
authors.forename: Luca
authors.initials: L
authors.lastname: Morelli
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Rosenberg
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008545:Melanoma / Q000175:diagnosis; D058628:Myofibroblasts / Q000473:pathology*; D009217:Myosarcoma / Q000175:diagnosis* / Q000378:metabolism; D012509:Sarcoma / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor