title: Propylthiouracil-induced acute liver failure: role of liver transplantation.
abstract: Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.
authors.affiliation: Department of Medicine, University of Miami Leonard M. Miller School of Medicine, 185 SW 7th Street, Unit 1510, Miami, FL 33130, USA.
authors.forename: Andres F
authors.initials: AF
authors.lastname: Carrion
authors.forename: Frank
authors.initials: F
authors.lastname: Czul
authors.forename: Leopoldo R
authors.initials: LR
authors.lastname: Arosemena
authors.forename: Gennaro
authors.initials: G
authors.lastname: Selvaggi
authors.forename: Monica T
authors.initials: MT
authors.lastname: Garcia
authors.forename: Akin
authors.initials: A
authors.lastname: Tekin
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Tzakis
authors.forename: Paul
authors.initials: P
authors.lastname: Martin
authors.forename: Ravi K
authors.initials: RK
authors.lastname: Ghanta