title: Organization of mutations along the genome: a prime determinant of genome evolution.
abstract: Recent advances in molecular mutagenesis reveal that two of the mechanisms which contribute to mutagen-induced point mutations, the frequency of induced DNA damage and the repair rate of this damage, vary considerably along the genome. At a grosser level of genomic resolution, cytogeneticists now distinguish several classes of chromosome bands along human chromosomes. The hot spots for X-ray induced breaks (chromosome mutations) occur in certain band classes, while the hot spots for mitomycin C-induced exchanges or melphalan-induced breaks occur in other band classes. Knowledge of these mutation patterns is modifying our concepts of genome evolution.
authors.affiliation: Gerald Holmquist is at the Beckman Research Institute of the City of Hope Medical Center, Duarte, CA 91010, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Holmquist
authors.forename: J
authors.initials: J
authors.lastname: Filipski