title: Wet versus dry age-related macular degeneration in patients with central field loss: different effects on maximum reading speed.
abstract: OBJECTIVE
  To describe new, efficient predictors of maximum reading speed (MRS) in age-related macular degeneration (AMD) patients with central field loss. Type of AMD (wet versus dry) was scrutinized, because this factor seems to offer a promising model of differential visual adaptation induced by different temporal courses of disease progression.
  
  
  METHODS
  Linear mixed-effects (LME) analyses were performed on a dataset initially collected to assess the effect of interline spacing on MRS. MRS was measured with MNread-like French sentences in 89 eyes (64 dry and 25 wet) of 61 patients with AMD. Microperimetry examination was performed on each eye. The eyes were included only if they had a dense macular scotoma including the fovea, to ensure that patients used eccentric viewing.
  
  
  RESULTS
  Analyses show the unique contributions--after adjustment for the effects of other factors--of three new factors: (1) MRS was higher for wet than for dry AMD eyes; (2) an advantage of similar amplitude was found for phakic eyes compared with pseudophakic eyes; and (3) MRS decreased when distance between fixation preferred retinal locus (PRL) and fovea increased. In addition, the instantaneous slope of the relationship between scotoma area and MRS was much shallower than reported in two other studies.
  
  
  CONCLUSIONS
  The four effects improve the ability to predict MRS reliably for AMD patients. The wet/dry difference is a major finding that may result from the different time courses of the two types of disease, thus involving different types of visuomotor and attentional adaptation processes.
authors.affiliation: Université Aix-Marseille II, CNRS (Centre Nationale de Recherche Scientifique), Institut de Neurosciences Cognitives de Méditerranée, Marseille, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Calabrèse
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Bernard
authors.forename: Louis
authors.initials: L
authors.lastname: Hoffart
authors.forename: Géraldine
authors.initials: G
authors.lastname: Faure
authors.forename: Fatiha
authors.initials: F
authors.lastname: Barouch
authors.forename: John
authors.initials: J
authors.lastname: Conrath
authors.forename: Eric
authors.initials: E
authors.lastname: Castet
mesh_terms: D000221:Adaptation, Ocular; D057092:Geographic Atrophy / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D017075:Laser Coagulation; D010778:Photochemotherapy; D011932:Reading; D012607:Scotoma / Q000503:physiopathology*; D058609:Visual Field Tests; D014794:Visual Fields; D057135:Wet Macular Degeneration / Q000503:physiopathology* / Q000628:therapy