title: History of animal models of stroke.
abstract: Scientists tend to focus on the present and the future. But the practice of experimental stroke is not new. Here, we reflect on the changing landscape of the stroke laboratory over the past 2000-years, focusing on shifts in the rationale for undertaking experiments, the methodologies deployed and the colourful characters involved in this science.
authors.affiliation: Department of Medicine, University of Melbourne, Heidelberg, Vic., Australia. ocollins@unimelb.edu.au
authors.forename: Victoria E
authors.initials: VE
authors.lastname: O'Collins
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Donnan
authors.forename: David W
authors.initials: DW
authors.lastname: Howells
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D013045:Species Specificity; D020521:Stroke / Q000266:history* / Q000473:pathology*