title: Systemic side effects of transtympanic steroids.
abstract: OBJECTIVE
  Review largest series of patients treated with transtympanic steroids, including outcomes, steroid dosing and adverse outcomes. Review first reported cases of systemic side effects from transtympanic steroids.
  
  
  METHODS
  A retrospective case series of 166 patients who underwent placement of transtympanic Silverstein tube with microwick for steroid administration was reviewed.
  
  
  RESULTS
  5/166 patients developed systemic side effects, 9/166 patients developed local side effects. 48/166 (29%) of patients had a persistent perforation after therapy. The percent of patients with improvement as a function of symptoms: hearing loss 42%, tinnitus 56%, vertigo 68%, aural fullness 25% and dysequilibrium 66%.
  
  
  CONCLUSIONS
  While our study revealed a significant risk of persistent tympanic membrane perforation, the incidence of systemic and local side effects from transtympanic steroid administration is low.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Nebraska, Medical Center, Nebraska, USA.
authors.forename: Ashley B
authors.initials: AB
authors.lastname: Robey
authors.forename: Trish
authors.initials: T
authors.lastname: Morrow
authors.forename: Gary F
authors.initials: GF
authors.lastname: Moore
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D016503:Drug Delivery Systems; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D034381:Hearing Loss / Q000188:drug therapy*; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014432:Tympanic Membrane
chemical_list: D005938:Glucocorticoids