title: Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
abstract: Oroidin was isolated from the marine sponge Agelassventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi.
authors.affiliation: Laboratório de Bioquímica Microbiana, Departamento de Microbiologia Geral, IMPPG, Universidade Federal do Rio de Janeiro, CEP 21941-590, Rio de Janeiro, RJ, Brazil.
authors.forename: Fernanda R
authors.initials: FR
authors.lastname: da Silva
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Tessis
authors.forename: Patricia F
authors.initials: PF
authors.lastname: Ferreira
authors.forename: Luciana P
authors.initials: LP
authors.lastname: Rangel
authors.forename: Aline S
authors.initials: AS
authors.lastname: Garcia-Gomes
authors.forename: Fabio R
authors.initials: FR
authors.lastname: Pereira
authors.forename: Roberto G S
authors.initials: RG
authors.lastname: Berlinck
authors.forename: Guilherme
authors.initials: G
authors.lastname: Muricy
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferreira-Pereira
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000187:drug effects*; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D018432:Drug Resistance, Multiple / Q000235:genetics; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000187:drug effects*
chemical_list: D018528:ATP-Binding Cassette Transporters; C092438:PDR5 protein, S cerevisiae; D011758:Pyrroles; D029701:Saccharomyces cerevisiae Proteins; C077209:oroidin