title: [Low penetrance gene polymorphisms involved in Helicobacter pylori-immune response. Relevance on gastric cancer risk].
abstract: Gastric cancer is a complex pathology which represents a worldwide health burden due to its high prevalence and poor prognosis. Therefore, prevention and early detection are considered the best options for controlling the disease. Current research is based on the study of genetic variants that confer a higher risk and their interactions with environmental exposure. A deeper knowledge of factors involved on gastric cancer development may allow identification of those individuals at elevated risk and will provide useful predictive information for subgroups of patients who need surveillance or early treatment strategies. In the present paper we review in a comprehensive manner, the most recent published studies on the contribution of gene polymorphisms and Helicobacter pylori infection to gastric cancer risk.
authors.affiliation: Servicio de Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
authors.forename: María
authors.initials: M
authors.lastname: Badía Martínez
authors.forename: Maria Asunción
authors.initials: MA
authors.lastname: García-González
mesh_terms: D003043:Cocarcinogenesis; D051546:Cyclooxygenase 2 / Q000235:genetics; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005756:Gastritis / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000453:epidemiology / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D009569:Nitric Oxide / Q000378:metabolism; D019683:Penetrance; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D036341:Intercellular Signaling Peptides and Proteins; D009569:Nitric Oxide; D051546:Cyclooxygenase 2