title: A novel transgenic mouse model of the human multiple myeloma chromosomal translocation t(14;16)(q32;q23).
abstract: Multiple myeloma (MM) is a currently incurable neoplasm of terminally differentiated B cells. The translocation and/or overexpression of c-MAF have been observed in human MM. Although c-MAF might function as an oncogene in human MM, there has been no report thus far describing the direct induction of MM by c-MAF overexpression in vivo. In this study, we have generated transgenic (TG) mice that express c-Maf specifically in the B-cell compartment. Aged c-Maf TG mice developed B-cell lymphomas with some clinical features that resembled those of MM, namely, plasma cell expansion and hyperglobulinemia. Quantitative RT-PCR analysis demonstrated that Ccnd2 and Itgb7, which are known target genes of c-Maf, were highly expressed in the lymphoma cells. This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis.
authors.affiliation: Department of Nephrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Morito
authors.forename: Keigyou
authors.initials: K
authors.lastname: Yoh
authors.forename: Atsuko
authors.initials: A
authors.lastname: Maeda
authors.forename: Takako
authors.initials: T
authors.lastname: Nakano
authors.forename: Akiko
authors.initials: A
authors.lastname: Fujita
authors.forename: Manabu
authors.initials: M
authors.lastname: Kusakabe
authors.forename: Michito
authors.initials: M
authors.lastname: Hamada
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism / Q000502:physiology; D002883:Chromosomes, Human, Pair 14; D002885:Chromosomes, Human, Pair 16; D004195:Disease Models, Animal; D006801:Humans; D006942:Hypergammaglobulinemia / Q000235:genetics / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009101:Multiple Myeloma / Q000235:genetics* / Q000378:metabolism; D051257:Proto-Oncogene Proteins c-maf / Q000096:biosynthesis / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C495607:MAF protein, human; C495608:Maf protein, mouse; D051257:Proto-Oncogene Proteins c-maf