title: Highly efficient and catalyst-free synthesis of substituted thioureas in water.
abstract: A highly efficient and catalyst-free method for the synthesis of substituted thiourea derivatives is presented. The synthesis is performed through the reaction of thiazolidine-2-thiones with various amines in water. A sound number of thioureas with both unsymmetrical and symmetrical architectures have been obtained in good to excellent yields.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
authors.forename: Shi-Feng
authors.initials: SF
authors.lastname: Gan
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Wan
authors.forename: Yuan-Jiang
authors.initials: YJ
authors.lastname: Pan
authors.forename: Cui-Rong
authors.initials: CR
authors.lastname: Sun
mesh_terms: D002384:Catalysis; D045162:Thiazolidinediones / Q000737:chemistry; D013871:Thiones / Q000737:chemistry; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D014867:Water
chemical_list: D045162:Thiazolidinediones; D013871:Thiones; C500091:thiazolidine-2,4-thione; D014867:Water; D013890:Thiourea