title: A water-soluble C60-porphyrin compound for highly efficient DNA photocleavage.
abstract: A water-soluble covalently linked C(60)-porphyrin compound-C(60)Por is reported to show enhanced DNA-cleaving activity. The highly enhanced DNA-cleaving activity is expected to be ascribed to the high water-solubility and affinity of C(60)Por to DNA, as well as to the accessibility to the charge-separated states C(60)˙(-)-Por˙(+) formed under radiation.
authors.affiliation: College of Chemistry, Sichuan University, Chengdu, China. zcs@scu.edu.cn
authors.forename: Cuisong
authors.initials: C
authors.lastname: Zhou
authors.forename: Qiaolin
authors.initials: Q
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Chunru
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Fang
mesh_terms: D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects* / Q000528:radiation effects*; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D008027:Light; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: C558421:C60-porphyrin; D037741:Fullerenes; D011166:Porphyrins; D014867:Water; D004247:DNA