title: Stereoselective construction of a 5-aza-spiro[2,4]heptane motif via catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides and ethyl cyclopropylidene acetate.
abstract: A direct and facile synthesis of highly functional 5-aza-spiro[2,4]heptanes, a valuable structural motif for drug discovery, is developed via catalytic asymmetric 1,3-dipolar cycloaddition of cyclopropylidene acetate and azomethine ylides for the first time.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China.
authors.forename: Tang-Lin
authors.initials: TL
authors.lastname: Liu
authors.forename: Zhao-Lin
authors.initials: ZL
authors.lastname: He
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tao
authors.forename: Yue-Peng
authors.initials: YP
authors.lastname: Cai
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D006536:Heptanes / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D001391:Azo Compounds; D006536:Heptanes; D013141:Spiro Compounds; D013882:Thiosemicarbazones; C512188:azomethine