title: [Clinicopathologic study of giant cell angioblastoma].
abstract: OBJECTIVE
  to study the clinicopathological features, imaging characteristics, immunophenotypes and differential diagnosis of giant cell angioblastoma (GCAB).
  
  
  METHODS
  a case of GCAB in the left middle-upper tibia and fibula was studied by light microscopy, X-ray and CT imaging, immunohistochemistry.
  
  
  RESULTS
  X-ray and CT imaging showed a clearer lesion in the left middle-upper tibia than in the ipsilateral fibula with enlarged ostealleosis and increased inhomogeneously medullary cavity density, irregular thickening of cortical bone, local cortical default at the inner edge, soft tissue swelling around the abnormal bone. Histologically, tumor tissue was located between the bone trabeculae by nodular, linear and plexiform aggregates of oval-to-spindle cells, large mononucleate cells and multinucleate giant cells with prominent nucleoli and abundant granular eosinophilic cytoplasm. Some aggregates had uncentain amount of discernible lumens, either empty or containing few erythrocytes. A concentric arrangement of oval-to-spindle Cells around small-caliber vascular structures together with collagen fiber contributed to a so-called 'onion-skin' arrangement. The background showed a loose mesenchymal stroma formed of some inconspicuous spindle-fibroblast-like cells, stellate-shape mesenchymal cells, a moderate mononuclear inflammatory cell infiltrate and scattered mast cells. Immunophenotype showed the tumor cells and giant cells strongly positive for vimentin. A good many oval-to-spindle cells stained markedly for CD31 and CD34, but weakly for FVIII, while the giant cells are highlighted instead by CD68, occasionally, very few giant cells showed positive focally for FVIII, a-SMA decorated notedly the cells surrounding the endothelium-like cells but weakly positive in some other tumor cells.
  
  
  CONCLUSIONS
  GCAB is a rare, locally infiltrative but slow growing neoplastic angiogenesis with unique morphological characteristics during infancy, which may occur not only in the skin, mucosa, subcutis and deep soft tissue but also in the bone.
authors.affiliation: Department of Pathology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, China. mrjys@163.com
authors.forename: Rong-Jun
authors.initials: RJ
authors.lastname: Mao
authors.forename: Qi-Ming
authors.initials: QM
authors.lastname: Li
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Guo
authors.forename: Wei-Qiang
authors.initials: WQ
authors.lastname: Li
authors.forename: Chang-Shu
authors.initials: CS
authors.lastname: Fan
authors.forename: Xiong-Zeng
authors.initials: XZ
authors.lastname: Zhu
mesh_terms: D000199:Actins / Q000378:metabolism; D015703:Antigens, CD / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018223:Dermatofibrosarcoma / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005360:Fibula; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018325:Hemangioblastoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006390:Hemangioendothelioma / Q000378:metabolism / Q000473:pathology; D018323:Hemangioendothelioma, Epithelioid / Q000378:metabolism / Q000473:pathology; D006392:Hemangioma, Cavernous / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007223:Infant; D059885:Kasabach-Merritt Syndrome; D008297:Male; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D012514:Sarcoma, Kaposi / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology; D013921:Thrombocytopenia / Q000378:metabolism / Q000473:pathology; D013977:Tibia; D014057:Tomography, X-Ray Computed; D019043:Vascular Neoplasms / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D000199:Actins; D015703:Antigens, CD; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014746:Vimentin; C541116:ACTA2 protein, human; C067980:CD68 antigen, human; D000097382:CD68 Molecule