title: Case report: First evidence of human zoonotic infection by Onchocerca lupi (Spirurida, Onchocercidae).
abstract: In the past decades, cases of canine ocular onchocercosis have been reported worldwide, particularly in the United States and Europe. Onchocerca lupi, originally described from a wolf, has been implicated in some of these cases, and its zoonotic role has been hypothesized on the basis of the reexamination of two cases of human ocular onchocerciasis. In the present study, we describe, for the first time, the occurrence of O. lupi in the subconjunctival region of the human eye in a patient from Turkey. The nematode was identified as O. lupi based on its morphology and molecular phylogenetic analysis of partial cox1 and 12S ribosomal DNA genes. The results suggest that O. lupi should be considered in the differential diagnosis of other eye parasitic infections in humans. The role of dogs as natural hosts of O. lupi and the vectors of this zoonotic parasite need to be investigated.
authors.affiliation: Department of Veterinary Public Health, Università degli Studi di Bari, Valenzano, Italy. d.otranto@veterinaria.uniba.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Otranto
authors.forename: Nermin
authors.initials: N
authors.lastname: Sakru
authors.forename: Gabriella
authors.initials: G
authors.lastname: Testini
authors.forename: Vuslat P
authors.initials: VP
authors.lastname: Gürlü
authors.forename: Konuralp
authors.initials: K
authors.lastname: Yakar
authors.forename: Riccardo P
authors.initials: RP
authors.lastname: Lia
authors.forename: Filipe
authors.initials: F
authors.lastname: Dantas-Torres
authors.forename: Odile
authors.initials: O
authors.lastname: Bain
mesh_terms: D000293:Adolescent; D000818:Animals; D003937:Diagnosis, Differential; D004197:Disease Reservoirs; D004199:Disease Vectors; D004283:Dog Diseases / Q000469:parasitology; D004285:Dogs; D005260:Female; D006801:Humans; D009854:Onchocerca / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D015827:Onchocerciasis, Ocular / Q000175:diagnosis / Q000469:parasitology* / Q000473:pathology; D010802:Phylogeny; D015047:Zoonoses