title: Co-treatment with Shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats.
abstract: Wei Kang Su (WKS) is an antioxidant-enriched herbal product manufactured on the basis of Shengmai San, a well-known traditional Chinese herbal formula. In the present study, we investigated the effects of WKS co-treatment on chronic ethanol toxicity in rats. WKS co-treatment protected against chronic ethanol-induced hepatotoxicity, as evidenced by the suppression of plasma enzyme activities and reactive oxygen metabolite levels, as well as the inhibition of hepatic mitochondrial malondialdehyde production in chronic ethanol-intoxicated rats. The hepatoprotection afforded by WKS co-treatment in chronic ethanol-intoxicated rats was associated with a reversal of altered hepatic mitochondrial antioxidant status and adenosine triphosphate (ATP) generation capacity, as well as heat shock protein 25/70 production. Therefore, WKS may offer the prospect of preventing ethanol-associated liver damage by increasing the resistance of mitochondria to oxidative stress.
authors.affiliation: Department of Biochemistry, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Po Yee
authors.initials: PY
authors.lastname: Chiu
authors.forename: Philip Y
authors.initials: PY
authors.lastname: Lam
authors.forename: Hoi Yan
authors.initials: HY
authors.lastname: Leung
authors.forename: Pou Kuan
authors.initials: PK
authors.lastname: Leong
authors.forename: Chung Wah
authors.initials: CW
authors.lastname: Ma
authors.forename: Qing Tao
authors.initials: QT
authors.lastname: Tang
authors.forename: Kam Ming
authors.initials: KM
authors.lastname: Ko
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002908:Chronic Disease; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; C486114:Hspb1 protein, rat; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination; D000431:Ethanol; D000255:Adenosine Triphosphate