title: No association between metal allergy and cardiac in-stent restenosis in patients with dermatitis-results from a linkage study.
abstract: BACKGROUND
  Percutaneous coronary intervention (PCI) with implantation of a metal stent is a common procedure performed in patients with symptomatic ischaemic heart disease. Intracoronary stents typically have a backbone of stainless steel, which contains nickel, chromium, and molybdenum, and it remains unclear whether individuals who are allergic to these metals have an increased risk of restenosis after PCI with stent implantation.
  
  
  OBJECTIVE
  To further evaluate whether dermatitis patients with nickel and/or chromium allergy had an increased risk of developing cardiac in-stent restenosis with stainless steel stents.
  
  
  METHODS
  An individual-level linkage study was performed to identify dermatitis patients who had been patch tested with the European baseline series between 1979 and 2007 at Gentofte University Hospital (N = 18794) and who had also undergone PCI at some point in a Danish hospital.
  
  
  RESULTS
  One hundred and forty-nine (0.8%) dermatitis patients who had undergone PCI with a metal stent were included. One hundred and forty-seven were patch-tested before undergoing PCI. Of the patients, 14.1% (21/149) had cardiac in-stent restenosis. Among patients with metal allergy, 2 (11.8%) had restenosis.
  
  
  CONCLUSIONS
  Nickel and/or chromium allergy in dermatitis patients does not appear to increase the overall risk of in-stent restenosis after PCI.
authors.affiliation: Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, DK-2900 Hellerup, Denmark.
authors.forename: Jacob P
authors.initials: JP
authors.lastname: Thyssen
authors.forename: Kåre
authors.initials: K
authors.lastname: Engkilde
authors.forename: Torkil
authors.initials: T
authors.lastname: Menné
authors.forename: Jeanne D
authors.initials: JD
authors.lastname: Johansen
authors.forename: Peter Riis
authors.initials: PR
authors.lastname: Hansen
authors.forename: Gunnar H
authors.initials: GH
authors.lastname: Gislason
mesh_terms: D000368:Aged; D015897:Comorbidity; D023903:Coronary Restenosis / Q000453:epidemiology*; D003872:Dermatitis / Q000453:epidemiology*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000453:epidemiology*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D019216:Metals, Heavy / Q000633:toxicity*; D008875:Middle Aged; D010328:Patch Tests; D012189:Retrospective Studies
chemical_list: D019216:Metals, Heavy