title: [Anticancer efficacy with cisplatin delivery systems].
abstract: The authors devised two different types of cisplatin (CDDP) delivery systems; namely, System A and System B. The anticancer efficacy with each system was examined using cancer-bearing animals. Seventy-percent deacetylated chitin (DAC-70) was used as the drug carrier in the system. Cancer-bearing animals were prepared by intra-peritoneally (ip) inoculating the MM-46 cancer cells to C3H mice. Each novel system was also ip injected to the cancer-bearing mouse, and then survival time of each animal was recorded to evaluate the anti-cancer efficacy of the system. Both Systems A and B were viscoelastic sol at 25°C and slowly changed to gel at 37°C. Four-week survival rate of each animal treated with the System was as follows: System A 6/10 (60%), System B 10/11 (90.9%), conventional CDDP alone 3/9 (33.3%) and non-treated 0/7 (0%). No signs of recurrence of ascites were encountered in the long-term survived animals treated with System A and B. Our newly devised systems provided a favorable antitumor efficacy in vivo. Now, we will carry out further studies by making a clinically applicable novel conjugated system, DAC-70 and CDDP.
authors.affiliation: Dept. of Surgery, Iwate Medical University.
authors.forename: Akio
authors.initials: A
authors.lastname: Sugitachi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kimura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Itabashi
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ikeda
authors.forename: Kazushige
authors.initials: K
authors.lastname: Ishida
authors.forename: Hironobu
authors.initials: H
authors.lastname: Noda
authors.forename: Teppei
authors.initials: T
authors.lastname: Matsuo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishizuka
authors.forename: Koki
authors.initials: K
authors.lastname: Otsuka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Koeda
authors.forename: Ayako
authors.initials: A
authors.lastname: Sato
authors.forename: Tomoki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Go
authors.initials: G
authors.lastname: Wakabayashi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013607:Tablets
chemical_list: D000970:Antineoplastic Agents; D013607:Tablets; D002945:Cisplatin