title: Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor.
abstract: A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.
authors.affiliation: Bio-Therapeutics Research Institute, KRIBB, Ochang, Republic of Korea. sangku@kribb.re.kr
authors.forename: Sangku
authors.initials: S
authors.lastname: Lee
authors.forename: Jae Nyoung
authors.initials: JN
authors.lastname: Kim
authors.forename: Hyeong Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Kab Seog
authors.initials: KS
authors.lastname: Yoon
authors.forename: Ki Deok
authors.initials: KD
authors.lastname: Shin
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
authors.forename: Dong Cho
authors.initials: DC
authors.lastname: Han
mesh_terms: D000840:Anisoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D058105:Polymerization; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry* / Q000378:metabolism; D050257:Tubulin Modulators / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C507623:5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole; D000840:Anisoles; D007555:Isoxazoles; D014404:Tubulin; D050257:Tubulin Modulators