title: Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets.
abstract: Chondrosarcoma, a primary malignancy of bone, has eluded successful treatment with modern chemotherapeutic and radiation regimens. To date, surgical resection of these tumors remains the only curative treatment offered to patients with this diagnosis. Understanding and exploring the nature of chemotherapy and radiation resistance in chondrosarcoma could lead to new molecular targets and more directed therapy for these notoriously difficult-to-treat tumors. Here we review the most current hypotheses regarding the molecular mechanisms mediating chemotherapy and radiation resistance and the future direction of chondrosarcoma therapy research.
authors.affiliation: Department of Orthopaedics, College of Physicians and Surgeons, Columbia University, Black Building, 14-1412, 650 West 168th Street, New York, NY 10032, USA.
authors.forename: Anne C
authors.initials: AC
authors.lastname: Onishi
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Hincker
authors.forename: Francis Y
authors.initials: FY
authors.lastname: Lee