title: [Risk factors and subjective symptoms of drug-induced leucopenia].
abstract: The present study investigated risk factors and subjective symptoms associated with drug-induced leucopenia. We selected 248 patients with drug-induced leucopenia from the Case Reports of Adverse Drug Reactions and Poisoning Information System (CARPIS) database of over 47000 case reports of adverse drug reactions and assigned them to a case group. We also randomly selected 743 cases of adverse drug reactions not associated with leucopenia as a control group. A comparison of patient characteristic data between the two groups using logistic-regression analysis revealed that female sex, autoimmune disease and renal damage were background risk factors for drug-induced leucopenia. In addition, thiamazole, ritodrine, propylthiouracil, ticlopidine, allopurinol, minocycline and captopril administration significantly increased the risk of drug-induced leucopenia. A significant association was also found for fever, chills and pharyngeal abnormalities. Based on these findings, we developed two estimated regression equations to help prevent drug-induced leucopenia in the community pharmacy setting.
authors.affiliation: Drug Informatics, Faculty of Pharmacy, Meijo University, Moriyama-ku, Nagoya, Japan. h.kyoko0324@hotmail.co.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ohtsu
authors.forename: Reiko
authors.initials: R
authors.lastname: Yano
authors.forename: Jinsaku
authors.initials: J
authors.lastname: Sakakibara
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Goto
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases; D016022:Case-Control Studies; D002648:Child; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007674:Kidney Diseases; D007970:Leukopenia / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D016015:Logistic Models; D008297:Male; D008713:Methimazole / Q000009:adverse effects; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D012307:Risk Factors; D012312:Ritodrine / Q000009:adverse effects; D012737:Sex Factors; D013988:Ticlopidine / Q000009:adverse effects; D055815:Young Adult
chemical_list: D008713:Methimazole; D012312:Ritodrine; D013988:Ticlopidine; D008727:Methotrexate