title: A novel approach to investigate neuronal network activity patterns affected by deep brain stimulation in rats.
abstract: The establishment of new therapeutic indications for deep brain stimulation (DBS) is ambitiously promoted though the underlying mechanisms remain contested. Here, we report that PET-imaging and subsequent c-Fos-immunostaining in rats constitute a new translational approach to further understand DBS-mechanisms and -effectiveness.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medicine Berlin, Charité Campus Mitte, Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Klein
authors.forename: Maria L
authors.initials: ML
authors.lastname: Soto-Montenegro
authors.forename: Javier
authors.initials: J
authors.lastname: Pascau
authors.forename: Lydia
authors.initials: L
authors.lastname: Günther
authors.forename: Andreas
authors.initials: A
authors.lastname: Kupsch
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.forename: Christine
authors.initials: C
authors.lastname: Winter
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000502:physiology*; D046690:Deep Brain Stimulation; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D019788:Fluorodeoxyglucose F18; D008297:Male; D009415:Nerve Net / Q000473:pathology / Q000502:physiology*; D049268:Positron-Emission Tomography; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D020531:Subthalamic Nucleus / Q000473:pathology / Q000502:physiology*; D057170:Translational Research, Biomedical
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D019788:Fluorodeoxyglucose F18