title: Glioblastoma multiforme at the corpus callosum with spinal leptomeningeal metastasis.
abstract: Glioblastoma multiforme (GBM) often occurs in the supratentorial white matter including corpus callosum. However, spinal leptomeningeal metastasis in cases of supratentorial GBM has been reported to be rare and there is usually a long interval between the cerebral lesion and the spinal seeding. We report here a case of GBM at the corpus callosum and other parts of the brain with simultaneous manifestation of spinal leptomeningeal seeding. The patient exhibited an abnormal motor behavior of the left hand as mirror movement when the right hand was performing a unimanual task (diagonistic dyspraxia) which is a sign of lesion of the posterior part and splenium of the corpus callosum. There were also signs of peripheral nerve or nerve root involvement suggestive of spinal metastasis without any sensory symptoms. He died 3 months after the onset of the symptoms confirming the poor prognosis and short survival time in cases with spinal leptomeningeal metastasis reported previously. The cerebral GBM with spinal seeding was disclosed at autopsy.
authors.affiliation: Division of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Pirada
authors.initials: P
authors.lastname: Witoonpanich
authors.forename: Krittika
authors.initials: K
authors.lastname: Bamrungrak
authors.forename: Artit
authors.initials: A
authors.lastname: Jinawath
authors.forename: Sansanee
authors.initials: S
authors.lastname: Wongwaisayawan
authors.forename: Suchart
authors.initials: S
authors.lastname: Phudhichareonrat
authors.forename: Rawiphan
authors.initials: R
authors.lastname: Witoonpanich
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000523:psychology; D003337:Corpus Callosum / Q000473:pathology*; D017809:Fatal Outcome; D005909:Glioblastoma / Q000473:pathology* / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000523:psychology / Q000556:secondary*; D008875:Middle Aged; D009366:Neoplasm Seeding; D009460:Neurologic Examination; D013116:Spinal Cord / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000523:psychology / Q000556:secondary*