title: Plasma omega 3 polyunsaturated fatty acid status and monounsaturated fatty acids are altered by chronic social stress and predict endocrine responses to acute stress in titi monkeys.
abstract: Disturbances in fatty acid (FA) metabolism may link chronic psychological stress, endocrine responsiveness, and psychopathology. Therefore, lipid metabolome-wide responses and their relationships with endocrine (cortisol, insulin, and adiponectin) responsiveness to acute stress (AS) were assessed in a primate model of chronic social stress (CS). Compared to controls (not exposed to CS), CS increased (P≤0.05) circulating triacylglycerol (TG) and phosphatidylethanolamine (PE) n-6/n-3 and reduced (P≤0.05) cholesterol ester (CE) 16:1n7 and phosphatidylcholine (PC) 18:1n7, suggesting lower omega-3 FA status and stearoyl-CoA desaturase activity, respectively. Cortisol responses to AS positively correlated with TG n-6/n-3 (r=0.93; P=0.007), but only in CS monkeys. The adiponectin response to AS inversely correlated with CE n-6/n3 (r=-0.89; P=0.045) and positively with TG 16:1n7 (r=0.98; P=0.004), only in CS monkeys. Our results are consistent with previously reported FA profiles in stress-related psychopathology and suggest that compositional changes of specific lipid FAs may form new functional markers of chronic psychological stress.
authors.affiliation: Western Human Nutrition Research Center/ARS/USDA, Davis, CA 95616, USA. kevin.laugero@ars.usda.gov
authors.forename: K D
authors.initials: KD
authors.lastname: Laugero
authors.forename: J T
authors.initials: JT
authors.lastname: Smilowitz
authors.forename: J B
authors.initials: JB
authors.lastname: German
authors.forename: M R
authors.initials: MR
authors.lastname: Jarcho
authors.forename: S P
authors.initials: SP
authors.lastname: Mendoza
authors.forename: K L
authors.initials: KL
authors.lastname: Bales
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D005229:Fatty Acids, Monounsaturated / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D000882:Haplorhini; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D010714:Phosphatidylethanolamines / Q000097:blood; D012919:Social Behavior; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism; D013315:Stress, Psychological / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D007328:Insulin; D010714:Phosphatidylethanolamines; D014280:Triglycerides; C483858:phosphatidylethanolamine; D013230:Stearoyl-CoA Desaturase; D006854:Hydrocortisone