title: Association between serum C-peptide levels and chronic microvascular complications in Korean type 2 diabetic patients.
abstract: This study evaluated the association between serum C-peptide levels and chronic vascular complications in Korean patients with type 2 diabetes. Data for 1,410 patients with type 2 diabetes were evaluated cross-sectionally. Fasting and postprandial 2-hour serum C-peptide levels were analyzed with respect to diabetic micro- and macrovascular complications. In the group of patients with lower fasting serum C-peptide quartile, the prevalences of diabetic retinopathy and neuropathy were significantly higher (P = 0.035, P < 0.001, respectively). In the group of patients with lower delta C-peptide (postprandial - fasting C-peptide) quartile, the prevalences of diabetic retinopathy, nephropathy, and neuropathy were significantly higher (P < 0.001 for all). Low delta C-peptide quartile was also associated with increased severity of retinopathy and nephropathy. The age- and sex-adjusted odds ratios (ORs) for retinopathy, neuropathy, and nephropathy in the lowest versus the highest delta C-peptide quartile were 6.45 (95% confidence interval 3.41-12.22), 3.01 (2.16-4.19), and 2.65 (1.71-4.12), respectively. After further adjustment for the duration of diabetes, type of antidiabetic therapy, mean hemoglobin A1c, body mass index, and blood pressure, the ORs were reduced to 2.83 (1.32-6.08), 1.68 (1.12-2.53), and 1.61 (1.05-2.47), respectively, but remained significant. No significant difference was observed in the prevalence of macrovascular complications with respect to fasting or delta C-peptide quartiles. These results suggest that low C-peptide level is associated with diabetic microvascular, but not macrovascular complications in patients with type 2 diabetes mellitus.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine, Jung-Dong, Wonmi-Gu, South Korea.
authors.forename: Bo-Yeon
authors.initials: BY
authors.lastname: Kim
authors.forename: Chan-Hee
authors.initials: CH
authors.lastname: Jung
authors.forename: Ji-Oh
authors.initials: JO
authors.lastname: Mok
authors.forename: Sung-Koo
authors.initials: SK
authors.lastname: Kang
authors.forename: Chul-Hee
authors.initials: CH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D002096:C-Peptide / Q000097:blood*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000097:blood / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D055815:Young Adult
chemical_list: D002096:C-Peptide