title: Adenine nucleotide transporters in organelles: novel genes and functions.
abstract: In eukaryotes, cellular energy in the form of ATP is produced in the cytosol via glycolysis or in the mitochondria via oxidative phosphorylation and, in photosynthetic organisms, in the chloroplast via photophosphorylation. Transport of adenine nucleotides among cell compartments is essential and is performed mainly by members of the mitochondrial carrier family, among which the ADP/ATP carriers are the best known. This work reviews the carriers that transport adenine nucleotides into the organelles of eukaryotic cells together with their possible functions. We focus on novel mechanisms of adenine nucleotide transport, including mitochondrial carriers found in organelles such as peroxisomes, plastids, or endoplasmic reticulum and also mitochondrial carriers found in the mitochondrial remnants of many eukaryotic parasites of interest. The extensive repertoire of adenine nucleotide carriers highlights an amazing variety of new possible functions of adenine nucleotide transport across eukaryotic organelles.
authors.affiliation: Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa UAM-CSIC, CIBER de Enfermedades Raras, Universidad Autónoma de Madrid, Madrid, Spain. jtraba@cbm.uam.es
authors.forename: Javier
authors.initials: J
authors.lastname: Traba
authors.forename: Jorgina
authors.initials: J
authors.lastname: Satrústegui
authors.forename: Araceli
authors.initials: A
authors.lastname: del Arco
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D056890:Eukaryota / Q000166:cytology / Q000378:metabolism; D006801:Humans; D000226:Mitochondrial ADP, ATP Translocases / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D010802:Phylogeny; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D000227:Adenine Nucleotides; D020033:Protein Isoforms; D000226:Mitochondrial ADP, ATP Translocases