title: Complex diel cycles of gene expression in coral-algal symbiosis.
abstract: Circadian regulation of plant-animal endosymbioses is complicated by a diversity of internal and external cues. Here, we show that stress-related genes in corals are coupled to the circadian clock, anticipating major changes in the intracellular milieu. In this regard, numerous chaperones are "hard-wired" to the clock, effectively preparing the coral for the consequences of oxidative protein damage imposed by symbiont photosynthesis (when O(2) > 250% saturation), including synexpression of antioxidant genes being light-gated. Conversely, central metabolism appears to be regulated by the hypoxia-inducible factor system in coral. These results reveal the complexity of endosymbiosis as well as the plasticity regulation downstream of the circadian clock.
authors.affiliation: Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Levy
authors.forename: P
authors.initials: P
authors.lastname: Kaniewska
authors.forename: S
authors.initials: S
authors.lastname: Alon
authors.forename: E
authors.initials: E
authors.lastname: Eisenberg
authors.forename: S
authors.initials: S
authors.lastname: Karako-Lampert
authors.forename: L K
authors.initials: LK
authors.lastname: Bay
authors.forename: R
authors.initials: R
authors.lastname: Reef
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez-Lanetty
authors.forename: D J
authors.initials: DJ
authors.lastname: Miller
authors.forename: O
authors.initials: O
authors.lastname: Hoegh-Guldberg
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000235:genetics* / Q000502:physiology; D053898:Biosynthetic Pathways / Q000235:genetics; D057906:Circadian Clocks; D002940:Circadian Rhythm; D004141:Dinoflagellida / Q000502:physiology*; D005786:Gene Expression Regulation; D006019:Glycolysis / Q000235:genetics; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D018832:Molecular Chaperones / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D010084:Oxidation-Reduction; D013312:Stress, Physiological; D013559:Symbiosis
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D018832:Molecular Chaperones