title: Serum concentrations of Helicobacter pylori IgG and the virulence factor CagA in patients with ischaemic heart disease.
abstract: To compare the serum concentrations of IgG to Helicobacter pylori and its virulence factor CagA in patients with ischaemic heart disease (IHD), we recruited 120 patients with IHD [acute myocardial infarction (AMI) (n = 60); unstable angina (UA) (n = 60)] and 60 sex- and age-matched healthy controls in this study. The seroprevalence of anti-H. pylori IgG was 86.7% in AMI, 91.7% in UA patients and 58.3% in the control group with mean titres of 33.2 U/ml [standard error (SE) 4.76], 57.96 U/ml (SE 7.54) and 25.72 U/ml (SE 4.01) respectively. The seroprevalence of anti-H. pylori in the patient groups was significantly higher than the control group. The mean levels of anti-H. pylori in the AMI and UA groups were also significantly higher than in the control group. The seroprevalence and mean titre of anti-CagA IgG did not differ significantly between patient and control groups.
authors.affiliation: Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Islamic Republic of Iran. Jafarzadeh14@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Jafarzadeh
authors.forename: A
authors.initials: A
authors.lastname: Esmaeeli-Nadimi
authors.forename: M
authors.initials: M
authors.lastname: Nemati
authors.forename: M
authors.initials: M
authors.lastname: Tahmasbi
authors.forename: P
authors.initials: P
authors.lastname: Ahmadi
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D000942:Antigens, Bacterial / Q000097:blood* / Q000276:immunology; D001426:Bacterial Proteins / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D017202:Myocardial Ischemia / Q000097:blood* / Q000453:epidemiology / Q000209:etiology*; D016036:Seroepidemiologic Studies
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C080866:cagA protein, Helicobacter pylori