title: Lymphocytic hypophysitis in children: a novel presentation and literature review.
abstract: Lymphocytic hypophysitis, an autoimmune mediated chronic inflammation of the pituitary gland, is uncommon in children.(1) The usual presentation is with symptoms secondary to pressure from the enlargement of the gland itself and or impairment of pituitary hormones of varying degrees, in conjunction with a sellar mass.( 2,3) In 80% of cases, partial or panhypopituitarism is present with approximately 75% of cases having multiple hormonal deficiencies.(2) We report the case of a prepubertal female who presented with cyclical vomiting, as her initial symptom of lymphocytic hypophysitis which resolved promptly after pituitary biopsy. This case suggests that cyclical vomiting can be a symptom associated with lymphocytic hypophysitis. Therefore, it should be considered in the differential diagnosis of any child presenting with cyclical vomiting.
authors.affiliation: Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA. akalra@lsuhsc.edu
authors.forename: Arun A
authors.initials: AA
authors.lastname: Kalra
authors.forename: Rosario Maria S
authors.initials: RM
authors.lastname: Riel-Romero
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gonzalez-Toledo
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000473:pathology*; D007249:Inflammation / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000473:pathology*; D014839:Vomiting / Q000209:etiology* / Q000473:pathology