title: [Expression of c-kit protein and its significance in human small cell lung cancer].
abstract: BACKGROUND
  To investigate the clinicopathological significance of c-kit protein expression in small cell lung cancer (SCLC).
  
  
  METHODS
  c-kit protein expression was detected in 52 formalin-fixed and paraffin-embedded SCLC, 20 non-small cell lung cancer (NSCLC) and 10 normal lung tissues by immunohistochemistry with rabbit antibody to human c-kit protein.
  
  
  RESULTS
  c-kit protein was expressed in 61.5% (32/52) of primary SCLC, but negative in all 20 samples of NSCLC and 10 normal lung tissues. c-kit protein was localized in cytoplasm of cancer cells. The expression of c-kit protein was related to tumor size ( P =0.010) and prognosis ( P =0.000 1), but not to sex ( P =0.208), age ( P =1.000) or TNM stage ( P =0.722) of SCLC.
  
  
  CONCLUSIONS
  c-kit protein expression may be corresponding to the prognosis of SCLC. Since in situ detection of c-kit protein is more direct than the other methods, it is helpful to clinicopathological diagnosis, targeted therapies interacting with c-kit signaling pathway and prognostic assessment in SCLC.
authors.affiliation: Department of Pathology, General Hospital of Chinese People's Liberation Army, Beijing 100853, P.R.China.
authors.forename: Xuege
authors.initials: X
authors.lastname: Jiang
authors.forename: Po
authors.initials: P
authors.lastname: Zhao