title: Pathogenesis and host control of gammaherpesviruses: lessons from the mouse.
abstract: Gammaherpesviruses are lymphotropic viruses that are associated with the development of lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most known gammaherpesviruses establish latency in B lymphocytes. Research on Epstein-Barr virus (EBV) and murine gammaherpesvirus 68 (MHV68/γHV68/MHV4) has revealed a complex relationship between virus latency and the stage of B cell differentiation. Available data support a model in which gammaherpesvirus infection drives B cell proliferation and differentiation. In general, the characterized gammaherpesviruses exhibit a very narrow host tropism, which has severely limited studies on the human gammaherpesviruses EBV and Kaposi's sarcoma-associated herpesvirus. As such, there has been significant interest in developing animal models in which the pathogenesis of gammaherpesviruses can be characterized. MHV68 represents a unique model to define the effects of chronic viral infection on the antiviral immune response.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Erik
authors.initials: E
authors.lastname: Barton
authors.forename: Pratyusha
authors.initials: P
authors.lastname: Mandal
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Speck
mesh_terms: D000818:Animals; D018142:Gammaherpesvirinae / Q000502:physiology*; D006566:Herpesviridae Infections / Q000276:immunology / Q000821:virology; D058507:Host Specificity; D006801:Humans; D051379:Mice; D014412:Tumor Virus Infections / Q000276:immunology / Q000821:virology