title: Triazole incorporated pyridazinones as a new class of antihypertensive agents: design, synthesis and in vivo screening.
abstract: A number of 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were designed and synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-4u) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e, 4i and 4k showed appreciable antihypertensive activity comparable with that of standard hydralazine and propranolol.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, India.
authors.forename: Anees A
authors.initials: AA
authors.lastname: Siddiqui
authors.forename: Ravinesh
authors.initials: R
authors.lastname: Mishra
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shaharyar
authors.forename: Asif
authors.initials: A
authors.lastname: Husain
authors.forename: Mohd
authors.initials: M
authors.lastname: Rashid
authors.forename: Palash
authors.initials: P
authors.lastname: Pal
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D011724:Pyridazines; D014230:Triazoles