title: [Reversal of pulmonary hypertrophic osteoarthropathy in surgically treated lung cancer].
abstract: A 61-year-old man was admitted for evaluation of an abnormal chest abnormal with progressive swelling in both hands, clubbing of all fingers and toes, and polyarthroceles. He was given a diagnosis of pulmonary hypertrophic osteoarthropathy (PHO) associated with primary lung cancer, and underwent an upper left lobectomy. Histopathological analysis revealed stage IIB adenocarcinoma of the lung with K-ras mutation, but with no evidence of epidermal growth factor receptor (EGFR). Postoperatively, his symptoms rapidly improved, and the preoperatively observed high levels of serum vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6) decreased to normal levels after just 1 month. VEGF and IL-6 caused by the genetic mutation of K-ras might play a role in the pathogenesis of PHO with lung cancer.
authors.affiliation: Center of Respiratory Medicine, Ohta Nishinouchi Hospital.
authors.forename: Yasuka
authors.initials: Y
authors.lastname: Hara
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Matsuura
authors.forename: Hiroto
authors.initials: H
authors.lastname: Takiguchi
authors.forename: Koken
authors.initials: K
authors.lastname: Ameku
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Numakura
authors.forename: Takashi
authors.initials: T
authors.lastname: Horie
authors.forename: Muneo
authors.initials: M
authors.lastname: Minowa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsumura
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000235:genetics / Q000601:surgery*; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008175:Lung Neoplasms / Q000150:complications* / Q000235:genetics / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology* / Q000628:therapy*; D011013:Pneumonectomy; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015850:Interleukin-6; D042461:Vascular Endothelial Growth Factor A