title: IGF-I and IGF Binding Protein-3 Generation Tests and Response to Growth Hormone in Children with Silver-Russell Syndrome.
abstract: Objectives. To evaluate, in children with Silver-Russell Syndrome, the response to the IGF-I and IGFBP-3 generation test and compare results to the growth response after 6 months of rhGH. Methods. Eight children (6 males), with a mean age of 5.71 ± 2.48 years and height SDS of -3.88 ± 1.28 received rhGH for 6 months. IGF-I and IGFBP-3 were analyzed before and after 4 doses of rhGH. Results. The mean growth velocity (GV) before treatment was 5.28 ± 1.9 cm/year. GV increased after rhGH in five children to a mean GV of 10.3 ± 3.64 cm/year. Six children had normal basal IGF-I levels and two low levels. After 4 doses of rhGH, the IGF-I levels were normal in seven. There was no correlation between the growth response and the IGF-I generation test. Conclusions. Children with SRS have normal IGF-I generation test. There is no correlation between the generation test and the growth velocity after 6 months of rhGH.
authors.affiliation: Divisão de Endocrinologia Pediátrica, Instituto de Puericultura e Pediatria Martagão Gesteira, Rua Bruno Lobo, 50, Rio de Janeiro, RJ 21941-912, Brazil.
authors.forename: Izabel C R
authors.initials: IC
authors.lastname: Beserra
authors.forename: Márcia G
authors.initials: MG
authors.lastname: Ribeiro
authors.forename: Paulo F
authors.initials: PF
authors.lastname: Collett-Solberg
authors.forename: Mário
authors.initials: M
authors.lastname: Vaisman
authors.forename: Marília M
authors.initials: MM
authors.lastname: Guimarães