title: Insights into cellular factors that regulate HIV-1 replication in human cells.
abstract: Retroviruses integrate into the host cell's chromosome. Accordingly, many aspects of the life cycle of retroviruses like HIV-1 are intimately linked to the functions of cellular proteins and RNAs. In this review, we discuss in brief recent genomewide screens for the identification of cellular proteins that assist HIV-1 replication in human cells. We also review findings for other cellular moieties that help or restrict the viral life cycle.
authors.affiliation: Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, U.K.
authors.forename: Andrew M L
authors.initials: AM
authors.lastname: Lever
authors.forename: Kuan-Teh
authors.initials: KT
authors.lastname: Jeang
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*
chemical_list: D014764:Viral Proteins