title: The relation of diabetes, impaired fasting blood glucose, and insulin resistance to left ventricular structure and function in African Americans: the Jackson Heart Study.
abstract: OBJECTIVE
  We assessed the relation of diabetes and insulin resistance (IR) on left ventricular (LV) structure and function in African Americans.
  
  
  METHODS
  Among those receiving echocardiograms in cycle 1 of the Jackson Heart Study, we assessed the sex-specific relation of fasting blood glucose (FBG), diabetes, and IR to LV structure and function, adjusting for age, systolic blood pressure, antihypertensive medications, and BMI.
  
  
  RESULTS
  Among 2,399 participants, LV mass index (P(women) = 0.0002 and P(men) = 0.02), posterior wall thickness (P(women) = 0.01 and P(men) = 0.05), and interventricular septal wall thickness (P(women) = 0.01) were related to FBG categories. Among those with normal FBG and no diabetes, concentric remodeling and low ejection fraction in women and LV mass index and posterior wall thickness in men were related to IR.
  
  
  CONCLUSIONS
  In the largest study of its kind in a community-based cohort of African Americans, we found a relation of FBG category and IR to LV structure and function.
authors.affiliation: Department of Family Medicine, CHA Hospital Anti-Aging Institute, Seoul, South Korea. efox@umc.edu
authors.forename: Ervin R
authors.initials: ER
authors.lastname: Fox
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Sarpong
authors.forename: Joe C
authors.initials: JC
authors.lastname: Cook
authors.forename: Tandaw E
authors.initials: TE
authors.lastname: Samdarshi
authors.forename: Harsha S
authors.initials: HS
authors.lastname: Nagarajarao
authors.forename: Philip R
authors.initials: PR
authors.lastname: Liebson
authors.forename: Mario
authors.initials: M
authors.lastname: Sims
authors.forename: George
authors.initials: G
authors.lastname: Howard
authors.forename: Robert
authors.initials: R
authors.lastname: Garrison
authors.forename: Herman A
authors.initials: HA
authors.lastname: Taylor
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology*; D004452:Echocardiography; D005215:Fasting; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000208:ethnology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D001786:Blood Glucose