title: Structure and regulation of L-type calcium channels a current assessment of the properties and roles of channel subunits.
abstract: L-type Ca channels are complex heteromultimeric proteins that play important roles in the cardiovascular system. Recent studies have revealed new insights into how the pore-forming α(1) subunits interact with accessory subunits to produce functional Ca channels. The function of L-type Ca channels is often regulated by receptor-mediated signal transduction events that are thought to result in the phosphorylation of proteins that comprise the Ca channels. Although the molecular events underlying phosphorylation based regulation have been intensely investigated with the use of electrophysiological approaches, surprisingly few details are known about the biochemical events involved, and many questions remain unanswered. © 1996, Elsevier Science Inc. (Trends Cardiovasc Med 1996;6:265-273).
authors.affiliation: Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School,Chicago, IL 60611,USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Hosey
authors.forename: A J
authors.initials: AJ
authors.lastname: Chien
authors.forename: T S
authors.initials: TS
authors.lastname: Puri