title: Venous giant post-thrombotic chronic ulcer: successful treatment with Bosentan.
abstract: OBJECTIVE
  To report a case of a refractory post-thrombotic chronic venous ulcer managed with an off-label treatment.
  
  
  METHODS
  We present the case of an 82-year-old woman with a previous medical history of severe hypertension and a deep vein thrombosis three years before. A refractory giant chronic venous ulcer in her left leg was treated with Bosentan.
  
  
  RESULTS
  The appearance of the ulcer improved in the first 45 days, worsened after an unintended stop of the treatment and was almost resolved after 90 days of treatment. Ulcer-associated pain improved very quickly and so, in only one week, opioid treatment was stopped. Bosentan treatment was well tolerated, with only mild and manageable side effects.
  
  
  CONCLUSIONS
  Treatment with Bosentan has been successful in the treatment of this case of refractory chronic venous ulcer.
authors.affiliation: University General Hospital Gregorio Marañón, Calle del Doctor Esquerdo 46, Madrid 28007, Spain. juanv.solis@gmail.com
authors.forename: J V
authors.initials: JV
authors.lastname: Solís
authors.forename: J L
authors.initials: JL
authors.lastname: Portero
authors.forename: L
authors.initials: L
authors.lastname: Ribé
mesh_terms: D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D000077300:Bosentan; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D012074:Remission Induction; D013449:Sulfonamides / Q000008:administration & dosage*; D014647:Varicose Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents; D013449:Sulfonamides; D000077300:Bosentan