title: Stem cell therapy: a future treatment of stress urinary incontinence.
abstract: The main urinary continence mechanism in human is the striated muscle rhabdosphincter that forms a ring around the mid-urethra. Cellular therapy and the use of stem cells transplanted into the site of the rhabdosphincter in a setting of stress urinary incontinence (SUI) may augment sphincter regeneration. Implanted cells may also release trophic factors promoting muscle and nerve integration into this muscle. We review the use of cellular therapy for SUI and our experience with the development of muscle-derived stem cells.
authors.affiliation: Department of Urology, William Beaumont Hospital, Royal Oak, Michigan, USA.
authors.forename: Dmitriy
authors.initials: D
authors.lastname: Nikolavasky
authors.forename: Klaudia
authors.initials: K
authors.lastname: Stangel-Wójcikiewicz
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Stec
authors.forename: Michael B
authors.initials: MB
authors.lastname: Chancellor
mesh_terms: D053687:Adult Stem Cells; D000818:Animals; D005260:Female; D006801:Humans; D039902:Multipotent Stem Cells; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology; D018657:Muscle Fibers, Slow-Twitch / Q000502:physiology; D009130:Muscle, Smooth / Q000294:innervation / Q000502:physiology; D009132:Muscles / Q000166:cytology / Q000294:innervation; D032446:Myoblasts; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000639:trends*; D014182:Transplantation, Autologous; D014521:Urethra; D014550:Urinary Incontinence, Stress / Q000601:surgery*