title: Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols.
abstract: Furo[2,3-f]quinolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida,Aspergillus species, and Cryptococcus neoformans. Among them tested, many furo[2,3-f]quinolin-5-ols showed good antifungal activity. The results suggest that furo[2,3-f]quinolin-5-ols would be promising antifungal agents.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea. ckryu@ewha.ac.kr
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
authors.forename: Yang Hui
authors.initials: YH
authors.lastname: Kim
authors.forename: Ji-Hee
authors.initials: JH
authors.lastname: Nho
authors.forename: Jung An
authors.initials: JA
authors.lastname: Hong
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Yoon
authors.forename: Aram
authors.initials: A
authors.lastname: Kim
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D006912:Hydroxyquinolines / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D006912:Hydroxyquinolines