title: [A long-term survival case of bilateral ovarian metastasis of progressive gastric cancer treated by chemotherapy].
abstract: We report a long-term survival case treated by chemotherapy with new anticancer drugs such as S-1, CPT-11 and docetaxel after bilateral overiectomy for bilateral ovarian metastases of progressive gastric cancer. A 68-year-old female, who had undergone total gastrectomy with D2 lymphadenectomy for scirrhous gastric cancer of Stage IIIA, was admitted because of ovarian metastasis. Laparoscopic bilateral ovariectomy was performed for ovarian metastases of the gastric cancer (Krukenberg tumor) 6 months after gastrectomy. Seven months after gastrectomy, 11-course of S-1 treatment (80 mg/m2) for bilateral ovarian metastases of the gastric cancer was administered. CT scan revealed mediastinal lymphadenopathy 2 years and 5 months after gastrectomy. Then, the drug was changed to docetaxel (60 mg/m2). After 9-course of docetaxel treatment, the mediastinal lymphadenopathy disappeared. For a treatment of grade 3 neuropathy, a 12-course CPT-11 was started after gastrectomy 3 years and 6 months ago. CT scan and PET-CT showed no new metastasis in 4 years and 10 months after gastrectomy.
authors.affiliation: Dept. of Surgery, Fukuyama City Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Fumitsugu
authors.initials: F
authors.lastname: Idani
authors.forename: Shinya
authors.initials: S
authors.lastname: Asami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Komoto
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kubota
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kumano
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kurose
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kubo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nojima
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Muro
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kin
authors.forename: Norihisa
authors.initials: N
authors.lastname: Takakura
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000473:pathology*; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077143:Docetaxel; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D000077146:Irinotecan; D007725:Krukenberg Tumor / Q000188:drug therapy* / Q000556:secondary*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D010052:Ovariectomy; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology*; D043823:Taxoids / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid; D000077146:Irinotecan; D002166:Camptothecin