title: Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy.
abstract: BACKGROUND
  Quantitative MRI techniques have demonstrated thalamocortical abnormalities in idiopathic generalized epilepsy (IGE). However, there are few studies examining IGE early in its course and the neurodevelopmental course of this region is not adequately defined.
  
  
  OBJECTIVE
  We examined the 2-year developmental course of the thalamus and frontal lobes in pediatric new-onset IGE (i.e., within 12 months of diagnosis).
  
  
  METHODS
  We performed whole-brain MRI in 22 patients with new-onset IGE and 36 age-matched healthy controls. MRI was repeated 24 months after baseline MRI. Quantitative volumetrics were used to examine thalamic and frontal lobe volumes.
  
  
  RESULTS
  The IGE group showed significant differences in thalamic volume within 1 year of seizure onset (baseline) and went on to show thalamic volume loss at a significantly faster rate than healthy control children over the 2-year interval. The control group also showed a significantly greater increase in frontal white matter expansion than the IGE group. In contrast, frontal lobe gray matter volume differences were moderate at baseline and persisted over time, indicating similar developmental trajectories with differences early in the disease process that are maintained.
  
  
  CONCLUSIONS
  Brain tissue abnormalities in thalamic and frontal regions can be identified very early in the course of IGE and an abnormal trajectory of growth continues over a 2-year interval.
authors.affiliation: Rosalind Franklin University of Medicine & Science, Department of Psychology, 3333 Green Bay Road, North Chicago, IL 60064, USA. dalin.pulsipher@my.rfums.org
authors.forename: D T
authors.initials: DT
authors.lastname: Pulsipher
authors.forename: K
authors.initials: K
authors.lastname: Dabbs
authors.forename: V
authors.initials: V
authors.lastname: Tuchsherer
authors.forename: R D
authors.initials: RD
authors.lastname: Sheth
authors.forename: M A
authors.initials: MA
authors.lastname: Koehn
authors.forename: B P
authors.initials: BP
authors.lastname: Hermann
authors.forename: M
authors.initials: M
authors.lastname: Seidenberg
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D004829:Epilepsy, Generalized / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000254:growth & development / Q000473:pathology*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000254:growth & development / Q000473:pathology; D010372:Pediatrics; D018709:Statistics, Nonparametric; D013788:Thalamus / Q000254:growth & development / Q000473:pathology*; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid