title: Single-bolus regional chemotherapy with doxorubicin versus chemoembolization in a rabbit VX2 tumor model.
abstract: OBJECTIVE
  This study evaluates the anti-tumor effect of regional chemotherapy compared with chemoembolization in an animal model.
  
  
  METHODS
  Twenty-one rabbits bearing VX2 liver tumors were divided into the following four groups: (a) the transarterial (TA) group (n=6) received a transarterial injection of doxorubicin through the hepatic artery (1 mg/kg); (b) the transarterial and transportal (TAP) group (n=6) received injections of doxorubicin through both the hepatic artery (1 mg/kg) and the portal vein (1 mg/kg); (c) the transarterial chemoembolization (TACE) group (n=6) received a transarterial injection of doxorubicin (1 mg/kg) followed by gelatin sponge embolization; and (d) the control group (n=3) received no treatment. With the use of computed tomography, tumor growth rates were calculated and microscopic examinations were performed to evaluate the extent of tumor necrosis.
  
  
  RESULTS
  Seven days after each treatment, the mean tumor growth rates were 216.7%±189.0% in the TA group, 77.1%±73.9% in the TAP group, and 489.5%±352.1% in the control group; there were no significant differences in tumor growth rates (P = 0.057). The tumor growth rate of the TACE group could not be evaluated due to extensive liver necrosis. The mean tumor necrosis rates were 41.9%±11.5% in the TA group, 51.4%±11.1% in the TAP group, 94.7%±3.5% in the TACE group, and 29.3%±6.7% in the control group; the TACE group showed significantly higher tumor necrosis than any other groups.
  
  
  CONCLUSIONS
  Single session regional chemotherapy has limited anti-tumor effects when compared with TACE in the rabbit VX2 tumor model.
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Sung Ki
authors.initials: SK
authors.lastname: Cho
authors.forename: Sung Wook
authors.initials: SW
authors.lastname: Shin
authors.forename: Young Soo
authors.initials: YS
authors.lastname: Do
authors.forename: Kee Taek
authors.initials: KT
authors.lastname: Jang
authors.forename: Sung Wook
authors.initials: SW
authors.lastname: Choo
authors.forename: Kwang Bo
authors.initials: KB
authors.lastname: Park
authors.forename: Hong Suk
authors.initials: HS
authors.lastname: Park
authors.forename: Il Soo
authors.initials: IS
authors.lastname: Chang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage*; D005781:Gelatin Sponge, Absorbable; D006490:Hemostatics; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D011817:Rabbits
chemical_list: D000903:Antibiotics, Antineoplastic; D006490:Hemostatics; D004317:Doxorubicin