title: TGF-β1 and BRCA2 expression are associated with clinical factors in breast cancer.
abstract: The objective of this study was to investigate the possible association between the expression of transforming growth factor beta-1 (TGF-β1) and breast cancer type2 susceptibility protein (BRCA2) with clinical factors in breast cancer. TGF-β1, BRCA2, human epidermal growth factor receptor2 (HER2), estrogen receptor, and progesterone receptor protein levels were measured in 67 samples from breast cancer patients by immunohistochemistry. The expression of these proteins was correlated with various clinical factors including age, pathohistological grade and status of axillary lymph node implication. TGF-β1 and BRCA2 were expressed in breast cancer tissues and expression of HER2 and TGF-β1 was significantly correlated with BRCA2. The authors conclude that elevated expression of BRCA2 correlates with TGF-β1 and HER2 in breast cancer and these three factors act in synergy to promote cancer. Thus, detection of both TGF-β1 and BRCA2 may therefore assist in the prognosis and treatment of breast cancer.
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Yangtze University, 434000 Hubei, China.
authors.forename: Junchuan
authors.initials: J
authors.lastname: Li
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhu
authors.forename: Tingxuan
authors.initials: T
authors.lastname: Chen
authors.forename: Guihua
authors.initials: G
authors.lastname: Dai
authors.forename: Lanying
authors.initials: L
authors.lastname: Zou
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D024682:BRCA2 Protein / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D024682:BRCA2 Protein; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D053773:Transforming Growth Factor beta1