title: [Flu vaccine and auto-immune and/or inflammatory diseases].
abstract: Patients with systemic inflammatory and/or autoimmune diseases have an increased risk of infections particularly severe influenza infections. Annually vaccination can prevent these infections. Available data about the influenza vaccine in these patients show that, it remains well tolerated and effective even if the antibody response is lower compared to healthy controls. These data encourage to vaccine every year patients with systemic inflammatory and/or autoimmune diseases with influenza vaccine, particularly patients taking immunosuppressant drugs or having respiratory, cardiac or renal chronic diseases according to guidelines. More data are needed about the severity of influenza infection and the efficacy of influenza vaccination in patients with systemic inflammatory and/or autoimmune diseases to improve their vaccine coverage.
authors.affiliation: Université Paris Descartes, Assistance publique-Hôpitaux de Paris (AP-HP), hôpital Cochin, centre d'investigation clinique de vaccinologie Cochin Pasteur, Inserm, CIC BT505, Paris, France.
authors.forename: Paula
authors.initials: P
authors.lastname: Duchet-Niedziolka
authors.forename: Thomas
authors.initials: T
authors.lastname: Hanslik
authors.forename: Luc
authors.initials: L
authors.lastname: Mouthon
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology*; D006387:Hemagglutination, Viral / Q000276:immunology; D006801:Humans; D007121:Immunocompetence / Q000187:drug effects / Q000276:immunology; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control*; D058873:Pandemics; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D007166:Immunosuppressive Agents; D007252:Influenza Vaccines