title: Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum.
abstract: Three new Lycopodium alkaloids, lyconadins D (1) and E (2), and complanadine E (3), were isolated from the club moss Lycopodium complanatum. Lyconadin D (1) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum. The structures and relative stereochemistry of 1-3 were elucidated on the basis of spectroscopic data. Complanadine E (3) enhanced mRNA expression for NGF.
authors.affiliation: Hokkaido University, Sapporo, Japan.
authors.forename: Kan'ichiro
authors.initials: K
authors.lastname: Ishiuchi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Haruaki
authors.initials: H
authors.lastname: Ishiyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hayashi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Shibata
authors.forename: Koichiro
authors.initials: K
authors.lastname: Mori
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Obara
authors.forename: Norimichi
authors.initials: N
authors.lastname: Nakahata
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D020932:Nerve Growth Factor / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; D012333:RNA, Messenger; C557833:complanadine E; C557832:lyconadin D; C557831:lyconadin E; D020932:Nerve Growth Factor