title: Next-generation genomics of Pseudomonas syringae.
abstract: The first wave of Pseudomonas syringae next-generation genomic studies has revealed insights into host-specific virulence and immunity, genome dynamics and evolution, and genetic and metabolic specialization. These studies have further enhanced our understanding of type III effector diversity, identified an atypical type III secretion system (T3SS) in a new clade of nonpathogenic P. syringae, identified metabolic pathways common to pathogens of woody hosts and revealed extensive genomic diversity among strains that infect common hosts. In general, these discoveries have illustrated the utility of draft genome sequencing for quickly and economically identifying candidate loci for more refined genetic and functional analyses.
authors.affiliation: Department of Cell and Systems Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada.
authors.forename: Heath E
authors.initials: HE
authors.lastname: O'Brien
authors.forename: Darrell
authors.initials: D
authors.lastname: Desveaux
authors.forename: David S
authors.initials: DS
authors.lastname: Guttman
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D019143:Evolution, Molecular; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D044224:Pseudomonas syringae / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D037521:Virulence Factors