title: Reduced serum vascular endothelial growth factor receptor-2 (sVEGFR-2) and sVEGFR-1 levels in gastric cancer patients.
abstract: The relationship between gastric cancer and serum vascular endothelial growth factor receptor-1 (sVEGFR-1) and sVEGFR-2, which are soluble form receptor proteins of vascular endothelial growth factor (VEGF), has not been extensively studied. VEGF, sVEGFR-1 and sVEGFR-2 were measured in the sera obtained before surgical operation from 164 gastric cancer patients and from 164 healthy controls matched for age and gender. Compared with controls, the cases showed elevated VEGF (P < 0.01) and reduced sVEGFR-1 (P = 0.07) and sVEGFR-2 (P = 0.02). The difference in VEGF levels was small among men and when the outcome was early cancer. The difference in sVEGFR-1 levels was significant or borderline significant only in men and when the outcome was diffuse type cancer. The difference in sVEGFR-2 levels was significant only in men and when the outcome was advanced or diffuse type cancer. The sensitivities and specificities of VEGF, sVEGFR-1 and sVEGFR-2 were all approximately 60%. For diffuse type cancer, sVEGFR-2 showed a sensitivity of 62.4% and a specificity of 63.4%, which was similar to serum pepsinogen. In conclusion, elevated VEGF and reduced sVEGFR-1 and sVEGFR-2 in serum are characteristic of gastric cancer patients, and the value of serum sVEGFR-2 in the diagnosis of diffuse type gastric cancer should be further evaluated.
authors.affiliation: Department of Public Health, Aichi Medical University, School of Medicine, Aichi, Japan. kikuchis@aichi-med-u.ac.jp
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Obata
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Yagyu
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.forename: Toshifusa
authors.initials: T
authors.lastname: Nakajima
authors.forename: Osamu
authors.initials: O
authors.lastname: Kobayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuichi
authors.forename: Ryo
authors.initials: R
authors.lastname: Ushijima
authors.forename: Michiko
authors.initials: M
authors.lastname: Kurosawa
authors.forename: Junko
authors.initials: J
authors.lastname: Ueda
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2