title: Impact of drug-eluting stents and diabetes mellitus in patients with coronary bifurcation lesions: a survey from the Italian Society of Invasive Cardiology.
abstract: BACKGROUND
  We investigated the long-term impact of different stent types and diabetes mellitus (DM) in patients undergoing percutaneous coronary intervention (PCI) of bifurcation lesions, based on a large multicenter survey endorsed by the Italian Society of Invasive Cardiology.
  
  
  RESULTS
  Relative benefits of drug eluting stent (DES) over bare metal stent (BMS) in patients with (n=1049) and without (n=3020) DM were analyzed with extensive multivariable adjustment. At 3 years, stenting with DES was associated with lower adjusted risk of major adverse cardiac events (MACE, adjusted hazard ratio [HR] 0.27, 95% confidence interval [CI] 0.15 to 0.49, P<0.001), cardiac death, and target lesion revascularization in DM patients but failed to demonstrate any significant benefit in patients without DM.
  
  
  CONCLUSIONS
  In a large observational registry with admitted potential for selection bias and residual confounding, DES in DM patients with coronary bifurcation lesions were associated with improved outcomes in terms of MACE, cardiac death, and repeat revascularization at long-term follow up. These figures were not replicated in non-DM subjects.
authors.affiliation: Cardiology Department, Ferrarotto Hospital, University of Catania, via Citelli 6, Catania, Italy. dcapodanno@gmail.com
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Sangiorgi
authors.forename: Enrico
authors.initials: E
authors.lastname: Romagnoli
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
authors.forename: Francesco
authors.initials: F
authors.lastname: Burzotta
authors.forename: Gabriele L
authors.initials: GL
authors.lastname: Gasparini
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bolognese
authors.forename: Leonardo
authors.initials: L
authors.lastname: Paloscia
authors.forename: Paolo
authors.initials: P
authors.lastname: Rubino
authors.forename: Gennaro
authors.initials: G
authors.lastname: Sardella
authors.forename: Carlo
authors.initials: C
authors.lastname: Briguori
authors.forename: Federica
authors.initials: F
authors.lastname: Ettori
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Franco
authors.forename: Domenico
authors.initials: D
authors.lastname: Di Girolamo
authors.forename: Imad
authors.initials: I
authors.lastname: Sheiban
authors.forename: Luigi
authors.initials: L
authors.lastname: Piatti
authors.forename: Cesare
authors.initials: C
authors.lastname: Greco
authors.forename: Anna Sonia
authors.initials: AS
authors.lastname: Petronio
authors.forename: Bruno
authors.initials: B
authors.lastname: Loi
authors.forename: Ernesto
authors.initials: E
authors.lastname: Lyoi
authors.forename: Alberto
authors.initials: A
authors.lastname: Benassi
authors.forename: Aldo
authors.initials: A
authors.lastname: Patti
authors.forename: Achille
authors.initials: A
authors.lastname: Gaspardone
authors.forename: Stefano
authors.initials: S
authors.lastname: De Servi
mesh_terms: D000368:Aged; D017130:Angioplasty; D003324:Coronary Artery Disease / Q000628:therapy*; D003920:Diabetes Mellitus; D003925:Diabetic Angiopathies / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome