title: Predictors of outcome in dogs treated with adjuvant carboplatin for appendicular osteosarcoma: 65 cases (1996-2006).
abstract: OBJECTIVE
  To determine outcomes and prognostic factors for those outcomes in dogs with appendicular osteosarcoma treated with curative-intent surgery and adjuvant carboplatin.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  65 client-owned dogs with appendicular osteosarcoma and no evidence of gross metastatic disease at the time of diagnosis.
  
  
  METHODS
  Medical records of dogs that underwent limb amputation or distal ulnectomy and adjuvant carboplatin treatment for appendicular osteosarcoma were reviewed. Adverse effects of chemotherapy and findings regarding preoperative biopsy specimens and postoperative diagnostic imaging were recorded. Signalment, clinical history, and chemotherapy variables were evaluated for associations with outcome. Histologic grade and other variables were evaluated for association with outcome for 38 tumors that were retrospectively graded.
  
  
  RESULTS
  The median disease-free interval was 137 days (95% confidence interval [CI], 112 to 177 days). Median survival time was 277 days (95% CI, 203 to 355 days). The 1-, 2-, and 3-year survival rates were 36%, 22%, and 19%, respectively. None of the chemotherapy variables were associated with outcome. Preoperative proteinuria was the only clinical variable associated with poor outcome. Histologic features of tumors associated with a poor outcome were intravascular invasion, mitotic index > 5 in 3 microscopic hpfs, and grade III classification.
  
  
  CONCLUSIONS
  Carboplatin administration was well tolerated and resulted in a disease-free interval and median survival time similar to those of other published protocols.
authors.affiliation: MedVet Medical and Cancer Center for Pets, 300 E Wilson Bridge Rd, Worthington, OH 43085, USA. dsaam@medvetohio.com
authors.forename: Dianna E
authors.initials: DE
authors.lastname: Saam
authors.forename: Julius M
authors.initials: JM
authors.lastname: Liptak
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Stalker
authors.forename: Ruthanne
authors.initials: R
authors.lastname: Chun
mesh_terms: D000671:Amputation, Surgical / Q000662:veterinary; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D016190:Carboplatin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D005260:Female; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy / Q000662:veterinary*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin