title: Glycerophospholipid synthesis as a novel drug target against cancer.
abstract: Tumor cells display progressive changes in metabolism that correlate with malignancy, including development of a lipogenic phenotype. Highly proliferating cancer cells need to synthesise fatty acids de novo to continually provide glycerophospholipids particularly for membrane production. The synthesised fatty acids are also used for energy production through β-oxidation and lipid modification of proteins. In addition, deregulated lipogenesis plays an important role in tumor cell survival and affects fundamental cellular processes, including signal transduction and gene expression. These observations suggest that enzymes involved in the pathways of lipid synthesis would be rational therapeutic targets in cancer. Over the past few decades, many substantial discoveries regarding enzymes and proteins acting in lipid synthesis have led to the current understanding of the complex signalling network implicated in the metabolic transduction pathways. This review presents an overview of mammalian glycerophospholipid synthesis, signal transduction and cellular distribution of the biochemical activities that produce distinct membrane lipid molecular species.
authors.affiliation: Department of Pharmaco-Biology, University of Calabria, 87036 Rende (CS), Italy. vdolce@unical.it
authors.forename: Vincenza
authors.initials: V
authors.lastname: Dolce
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Cappello
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Lappano
authors.forename: Marcello
authors.initials: M
authors.lastname: Maggiolini
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D020404:Glycerophospholipids / Q000096:biosynthesis*; D006801:Humans; D050155:Lipogenesis / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D015398:Signal Transduction
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D005227:Fatty Acids; D020404:Glycerophospholipids; D064429:Fatty Acid Synthases