title: [Long-term survival of patient with gastric cancer treated by S-1 + paclitaxel combination chemotherapy against multiple liver metastases after gastrectomy and adrenalectomy].
abstract: The patient was a 74-year-old man whose chief complaint was epigastralgia. A detailed examination revealed a gastric cancer located from antrum to duodenal bulb with multiple liver metastases. Because of a difficulty with oral intake, we performed a distal gastrectomy at first. After the operation, a combination chemotherapy with S-1 and weekly paclitaxel was performed, and liver metastases were successfully disappeared after 4 courses of the regimen. A subsequent CT evaluation after 6 courses of the regimen revealed that liver metastases maintained the clinical complete response (cCR), but a right adrenal tumor was detected. We performed a right adrenalectomy after 13 months from gastrectomy, and a histopathological examination revealed that the adrenal tumor was a recurrent gastric cancer. After the second operation, only one course treatment of S-1 alone was performed because the patient rejected the chemotherapy. The patient is alive without a chemotherapy and maintained cCR for 75 months after the second operation.
authors.affiliation: Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Itokawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shioaki
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Sonoda
authors.forename: Jun
authors.initials: J
authors.lastname: Ikeda
authors.forename: Kazuma
authors.initials: K
authors.lastname: Koide
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Taniguchi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ueshima
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Takashina
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary / Q000601:surgery; D000315:Adrenalectomy; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel