title: A feline rotavirus G3P[9] carries traces of multiple reassortment events and resembles rare human G3P[9] rotaviruses.
abstract: The full-length genome sequence of a feline G3P[9] rotavirus (RV) strain, BA222, identified from the intestinal content of an adult cat, was determined. Strain BA222 possessed a G3-P[9]-I2-R2-C2-M2-A3-N1-T3-E2-H3 genomic constellation, differing substantially from other feline RVs. Phylogenetic analyses of each genome segment revealed common origins with selected animal and zoonotic human RVs, notably with rare multi-reassortant human G3P[9] RVs (Ita/PAI58/96 and Ita/PAH136/96). Altogether, the findings suggest that feline RVs are genetically diverse and that human RVs may occasionally originate either directly or indirectly (via reassortment) from feline RVs.
authors.affiliation: Department of Veterinary Public Health, University of Bari, Valenzano, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Martella
authors.affiliation: Ondersterpoort Veterinary Institute, South Africa.
authors.forename: A C
authors.initials: AC
authors.lastname: Potgieter
authors.affiliation: Department of Veterinary Public Health, University of Bari, Valenzano, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Lorusso
authors.affiliation: Department of Health Promotion Sciences 'G. D'Alessandro', University of Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: De Grazia
authors.affiliation: Department of Health Promotion Sciences 'G. D'Alessandro', University of Palermo, Italy.
authors.forename: G M
authors.initials: GM
authors.lastname: Giammanco
authors.affiliation: Rega Institute for Medical Research, Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Matthijnssens
authors.affiliation: Veterinary Medical Research Institute, Hungarian Academy of Sciences, Hungária krt. 21, H-1143 Budapest, Hungary.
authors.forename: K
authors.initials: K
authors.lastname: Bányai
authors.affiliation: Infectious Diseases and Vaccines - Clinical Research, Merck Research Laboratory, North Wales, Pennsylvania, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ciarlet
authors.affiliation: Istituto Zooprofilattico Sperimentale di Lombardia ed Emilia Romagna, Brescia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lavazza
authors.affiliation: Department of Veterinary Public Health, University of Bari, Valenzano, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Decaro
authors.affiliation: Department of Veterinary Public Health, University of Bari, Valenzano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D002415:Cats; D016000:Cluster Analysis; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics* / Q000302:isolation & purification*; D012401:Rotavirus / Q000235:genetics* / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral