title: Grapefruit juice--drug interactions: importance for pharmacotherapy.
abstract: In spite of known health benefits of grapefruit juice, its consumption in combination with drugs requires caution. The drugs most susceptible to pharmacokinetic interactions with clinical significance are those with narrow therapeutic index and low bioavailability due to important first-pass metabolism. Most vulnerable populations are elderly, cirrhotics, subjects with genetic polymorphisms and individuals taking other CYP3A4 inhibitors. The major drug classes that have been reported to present interactions with grapefruit juice are antiallergics, antibiotics, antimalaria drugs, anxiolytics, calcium channel blockers, HIV protease inhibitors, HMG-CoA reductase inhibitors; the degree of pharmacokinetic interaction varies among the compounds of the same class.
authors.affiliation: Department of Pharmacology, School of Dental Medicine, Gr.T. Popa University of Medicine and Pharmacy Iaşi.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Cuciureanu
authors.forename: L
authors.initials: L
authors.lastname: Vlase
authors.forename: Dana
authors.initials: D
authors.lastname: Muntean
authors.forename: Irina
authors.initials: I
authors.lastname: Varlan
authors.forename: Rodica
authors.initials: R
authors.lastname: Cuciureanu
mesh_terms: D018926:Anti-Allergic Agents / Q000493:pharmacokinetics; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D000962:Antimalarials / Q000493:pharmacokinetics; D001628:Beverages / Q000009:adverse effects*; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics; D032083:Citrus paradisi / Q000009:adverse effects*; D018565:Food-Drug Interactions; D017320:HIV Protease Inhibitors / Q000493:pharmacokinetics; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000493:pharmacokinetics; D012307:Risk Factors
chemical_list: D018926:Anti-Allergic Agents; D014151:Anti-Anxiety Agents; D000900:Anti-Bacterial Agents; D000962:Antimalarials; D002121:Calcium Channel Blockers; D017320:HIV Protease Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors