title: Nardosinane sesquiterpenoids from the Formosan soft coral Lemnalia flava.
abstract: Four new nardosinane-type sesquiterpenoids, flavalins A-D (1-4), have been isolated from the Formosan soft coral Lemnalia flava. The structures of the new metabolites were determined by extensive spectroscopic analysis, and the structure of 2 was confirmed by X-ray diffraction analysis. A plausible biosynthetic pathway to 1 and 2 is proposed. Compound 1 was found to display dose-dependent inhibition of iNOS protein expression, and 1 and 2 were shown to possess significant neuroprotective activity.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: Po-Ju
authors.initials: PJ
authors.lastname: Li
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Hung
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C557422:flavalin A; C557423:flavalin B; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II