title: Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderly.
abstract: Traditional tests used in the clinic to identify dementia, such as the mini-mental state examination (MMSE), are useful to identify severe cognitive impairments but might be less sensitive to detect more subtle age-related cognitive changes. Previously, the novel image-novel location (NINL) object recognition test was shown to be sensitive to detect effects of apolipoprotein E4, a risk factor for developing age-related cognitive decline and Alzheimer's disease, in nondemented elderly. In the present longitudinal study, performance on the MMSE and the NINL tests were compared over a 4-year period. Individual NINL scores over this period were highly correlated. In addition, while MMSE scores did not change over the 4-year period, NINL scores did. In a final testing session of a subset of the participants, NINL scores correlated with logical memory and word recall lists, cognitive tasks used to detect dementia in the clinic, as well as clinical dementia rating scales. These results support that the NINL might be a valuable tool to assess age-related cognitive decline.
authors.affiliation: Behavioral Neuroscience Department, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: Gwendolen E
authors.initials: GE
authors.lastname: Haley
authors.forename: Frederique
authors.initials: F
authors.lastname: Berteau-Pavy
authors.forename: Daphnee
authors.initials: D
authors.lastname: Berteau-Pavy
authors.forename: Jacob
authors.initials: J
authors.lastname: Raber
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D053327:Apolipoprotein E4 / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003072:Cognition Disorders / Q000097:blood* / Q000523:psychology*; D006801:Humans; D008137:Longitudinal Studies; D009483:Neuropsychological Tests; D009922:Oregon; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D015415:Biomarkers