title: Evaluation of some pharmaceutical formulations of lisinopril through dissolution testing.
abstract: OBJECTIVE
  Lisinopril is a drug of the angiotensin converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. We compared the dissolution profiles of Lisinopril 20 mg tablets (Antibiotice S.A. laşi) and Zestril 20 mg tablets (Astra Zeneca).
  
  
  METHODS
  Because lisinopril is a third class active substance, we performed dissolution tests in standard media at three pH values: 1.2, 4.5 and 6.8 using the paddle apparatus at 75 rpm.
  
  
  RESULTS
  Both pharmaceutical formulations present a dissolution percentage more than 85% (Q) of the labeled amount.
  
  
  CONCLUSIONS
  Both pharmaceutical formulations present similar dissolution profile. Key words:
authors.affiliation: Department of Analytical Chemistry, School of Pharmacy, Gr.T. Popa University of Medicine and Pharmacy Iaşi.
authors.forename: Mădălina
authors.initials: M
authors.lastname: Vieriu
authors.forename: Nela
authors.initials: N
authors.lastname: Bibire
authors.forename: M
authors.initials: M
authors.lastname: Apostu
authors.forename: Cristina
authors.initials: C
authors.lastname: Tocu
authors.forename: V
authors.initials: V
authors.lastname: Dorneanu
authors.forename: Cristina
authors.initials: C
authors.lastname: Vlase
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D017706:Lisinopril / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D013607:Tablets; D017706:Lisinopril