title: Racial differences in the incidence of mesenchymal tumors associated with EWSR1 translocation.
abstract: BACKGROUND
  The incidence of Ewing sarcoma varies by race, with very low rates among persons of African and East Asian ancestry. The incidence by race of other mesenchymal tumors that also harbor EWSR1 translocations has not been studied.
  
  
  METHODS
  The SEER database was queried to find cases of mesenchymal tumors associated with EWSR1 translocations: Ewing sarcoma; clear cell sarcoma; extraskeletal myxoid chondrosarcoma; myxoid liposarcoma; desmoplastic small round cell tumor; and myoepithelial tumor. Age-adjusted incidence rates were calculated for white, African American, and Asian/Native American populations and compared statistically.
  
  
  RESULTS
  Ewing sarcoma was significantly less common in the African American and Asian/Native American populations compared with the white population, with incidence rate ratios of 0.12 (95% CI, 0.08-0.20; P<0.001) and 0.54 (95% CI, 0.41-0.69; P<0.001), respectively. Desmoplastic small round cell tumor was significantly more common in the African American population compared with the white population (incidence rate ratio=3.0; 95% CI, 1.62-5.49; P<0.001). Myxoid liposarcoma was significantly less common in the Asian/Native American population compared with the white population (incidence rate ratio=0.72; 95% CI, 0.56-0.92; P=0.006). The incidence rates for extraskeletal myxoid chondrosarcoma, myoepithelial tumors, and clear cell sarcoma did not differ significantly by race.
  
  
  CONCLUSIONS
  Tumors associated with EWSR1 translocation are not uniformly more common in people of European ancestry.
  
  
  CONCLUSIONS
  The relationship between race and EWSR1 somatic translocation is complex. Future studies investigating the genetic epidemiology of EWSR1 translocated tumors are required.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, School of Medicine, 505 Parnassus Avenue, M646, San Francisco, CA 94143-0106, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Worch
authors.forename: Jobin
authors.initials: J
authors.lastname: Cyrus
authors.forename: Robert
authors.initials: R
authors.lastname: Goldsby
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Matthay
authors.forename: John
authors.initials: J
authors.lastname: Neuhaus
authors.forename: Steven G
authors.initials: SG
authors.lastname: DuBois
mesh_terms: D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D006801:Humans; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics*; D018426:SEER Program; D012512:Sarcoma, Ewing / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D014178:Translocation, Genetic; D014481:United States / Q000453:epidemiology
chemical_list: D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins