title: Computed tomography angiography in children with cardiovascular disease: low dose techniques and image quality.
abstract: Dose reduction techniques for computed tomography angiography (CTA) in children with cardiovascular diseases have the potential of reducing risks of radiation-induced cancer. To evaluate effectiveness of these techniques, both radiation dose and image quality must be compared. While clinically practical methods of estimating effective dose are available, there are no generally accepted metrics for the assessment of image quality in CTA. We introduce a measurable and reproducible image quality index, CTA QI. Using this index, along with calculated effective dose, we test the hypothesis that volume scan CTA delivers comparable image quality at substantially reduced radiation dose when compared to helical CTA. CTA QI is a measure of intraluminal contrast variation in three-dimensions, and it is calculated from standardized measurements of means and standard deviations of Hounsfield units in the thoracic descending aorta. From institutional database, 83 studies of CTA for thoracic cardiovascular diseases were retrospectively identified. CTA QI values were independently measured by two radiologists and compared using correlation. CTA QI and DLP-derived effective dose were compared for the following groups: non-cardiac gated wide-detector and helical CTA, ECG-synchronized retrospective wide-detector and helical CTA, ECG-synchronized wide detector retrospective and target technique CTA. Statistical significance was evaluated with the Student-t test. The correlations of CTA QI values between the radiologists were 0.83 and 0.92 for non-gated studies and ECG-synchronized studies respectively. Comparing non-gated volume scan CTA to helical CTA, there was a radiation dose reduction of 69% (P < 0.0001) without a significant change in CTA QI (1.4 ± 1.0 vs. 1.9 ± 1.4, P = 0.13). Comparing retrospective ECG-synchronized wide-detector CTA to helical CTA, there was a radiation dose reduction of 46% (P < 0.0001) with and improvement in CTA QI (1.0 ± 0.8 vs. 3.7 ± 3.4, P < 0.01). Comparing ECG-synchronized wide-detector target CTA to retrospective CTA, there was a radiation dose reduction of 68% (P < 0.0001, but at the cost of a significant reduction in CTA QI (2.0 ± 1.0 vs. 0.8 ± 0.4, P < 0.0044). CTA QI is a simple, reproducible metric of image quality suited for comparing CTA studies. Using this quality index, we establish that CTA performed with wide-detector scan techniques can yield substantially lower radiation dose without compromising diagnostic imaging quality. A wide-detector target technique can further reduce effective dose compared to wide-detector retrospective ECG-synchronization, but with a reduction in image quality.
authors.affiliation: Department of Radiology, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA. greenbergsbruce@uams.edu
authors.forename: S Bruce
authors.initials: SB
authors.lastname: Greenberg
authors.forename: Sadaf
authors.initials: S
authors.lastname: Bhutta
authors.forename: Leah
authors.initials: L
authors.lastname: Braswell
authors.forename: Frandics
authors.initials: F
authors.lastname: Chan
mesh_terms: D055424:Cardiac-Gated Imaging Techniques / Q000379:methods; D002675:Child, Preschool; D017023:Coronary Angiography / Q000379:methods* / Q000592:standards*; D004562:Electrocardiography; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D036542:Tomography, Spiral Computed / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards*