title: Efficacy of prolonged valganciclovir therapy for congenital cytomegalovirus infection.
abstract: We report prolonged valganciclovir (VGCV) treatment of a symptomatic cytomegalovirus infection case. Automated auditory brainstem evoked response performed at 5 days of age revealed severe hearing impairment. Cranial magnetic resonance (MR) imaging at 11 days of age showed abnormal findings. At 5 weeks of age, VGCV was started. The viral load in blood cells, plasma, and urine decreased during the 6-week treatment. Because of improvement of hearing level and no adverse effects, VGCV was restarted for an additional 6 weeks. Neither the patient's hearing impairment nor results of cranial MR imaging have become worse in 6 months. It is crucial to gather information from as many cases as possible treated with VGCV to establish a standard protocol for VGCV treatment.
authors.affiliation: Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan. hoyohoyo@tokyo-med.ac.jp
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Kashiwagi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Junya
authors.initials: J
authors.lastname: Nakajima
authors.forename: Yu
authors.initials: Y
authors.lastname: Ishida
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nishimata
authors.forename: Tasuku
authors.initials: T
authors.lastname: Miyajima
authors.forename: Kouji
authors.initials: K
authors.lastname: Takekuma
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
authors.forename: Naoki
authors.initials: N
authors.lastname: Inoue
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D001921:Brain / Q000000981:diagnostic imaging; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000821:virology; D004279:DNA, Viral / Q000097:blood / Q000652:urine; D016057:Evoked Potentials, Auditory, Brain Stem; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D034381:Hearing Loss / Q000821:virology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D000077562:Valganciclovir; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D000077562:Valganciclovir; D015774:Ganciclovir