title: Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency.
abstract: OBJECTIVE
  The aim of this study was to determine the value of systemic biochemical markers of bone turnover-urine levels of cross-linked C-terminal telopeptide I (uCTX-I), urinary C-terminal telopeptide II (uCTX-II) and serum cartilage oligomeric matrix protein (sCOMP)-in the diagnosis of chondral defects after anterior cruciate ligament (ACL) rupture. Thirty-eight patients with previous ACL rupture were included.
  
  
  METHODS
  Magnetic resonance imaging (MRI) of the injured and the intact knee joint was performed with volumetric measurement of volume and area of cartilage (VC/AC), area of subchondral bone (cAB), and area of subchondral bone denuded and eroded (dAB). Biochemical markers were measured using commercially available enzyme-linked immunoassays.
  
  
  RESULTS
  MRI-based volumetric cartilage measurement showed significant differences between the injured and the intact knees. uCTX-I, sCOMP and in parts uCTX-II correlated well with MRI parameters. CTX-I showed a significant correlation with VC and AC of the whole knee joint.
  
  
  CONCLUSIONS
  The results suggest that uCTX-I, uCTX-II and sCOMP could identify patients with focal cartilage lesions from an early stage of osteoarthritis of the knee.
authors.affiliation: Department of Orthopaedic Sports Medicine, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany. Nikolaus.Streich@med.uni-heidelberg.de
authors.forename: Nikolaus A
authors.initials: NA
authors.lastname: Streich
authors.forename: David
authors.initials: D
authors.lastname: Zimmermann
authors.forename: Holger
authors.initials: H
authors.lastname: Schmitt
authors.forename: Gerrit
authors.initials: G
authors.lastname: Bode
mesh_terms: D000328:Adult; D016118:Anterior Cruciate Ligament / Q000378:metabolism / Q000473:pathology*; D000070598:Anterior Cruciate Ligament Injuries; D015415:Biomarkers / Q000378:metabolism; D064236:Cartilage Oligomeric Matrix Protein; D024042:Collagen Type I / Q000378:metabolism*; D024043:Collagen Type II / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis* / Q000503:physiopathology; D007719:Knee Joint / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D064235:Matrilin Proteins; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D010455:Peptides / Q000378:metabolism*; D012421:Rupture
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024042:Collagen Type I; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010455:Peptides; C577553:TSP5 protein, human; C052929:collagen type I trimeric cross-linked peptide