title: Influence of estroprogestinic therapy on the postoperative course following impacted third molar extraction.
abstract: OBJECTIVE
  Female patients on estroprogestinic therapy undergoing extraction of the third lower molar have a higher incidence of postoperative complications (dry socket -DS- pain). The purpose of this study is to verify such data and analyse if there are risk factors for the appearance of other postoperative complications.
  
  
  METHODS
  One hundred eighteen non-smoking healthy patients were included who underwent extraction of the impacted third lower molar (38 on oral contraceptives, OC, 80 as control). After the extraction, patients were prescribed with a pharmacological therapy, consisting of a per os antibiotic and antiseptic rinse. Each patient was examined after 7 days following surgery to verify the state of tissues. In addition subjective postoperative pain (VAS - Visual Analogue Scale) and intake of analgesic drugs were recorded.
  
  
  RESULTS
  One case of DS (2.64%) occurred in the OC group, and 1 case of DS occurred in control-patients group (1.25%) (P=0.4436). The postoperative pain proved significantly higher in OC compared to control (first and fifth postoperation day). In OC a predisposition to dehiscence of the wound (86.84% P=0.0021) and emergence of laterocervical lymphadenitis (81.57% P=0.0010) was found, while no cases of postextractive abscesses and trismus of the masseter were found.
  
  
  CONCLUSIONS
  Although no correlation between DS and estroprogestinic therapy has been found, a more difficult healing of tissues has been observed as well as a significantly higher subjective pain index in the postoperative days considered in OC patients.
authors.affiliation: Department of Oral Surgery, University of Padua, Institute of Clinical Dentistry, Padua, Italy. stefano.sivolella@libero.it
authors.forename: S
authors.initials: S
authors.lastname: Sivolella
authors.forename: G
authors.initials: G
authors.lastname: Boccuzzo
authors.forename: M
authors.initials: M
authors.lastname: Franco
authors.forename: E
authors.initials: E
authors.lastname: Stellini
authors.forename: A
authors.initials: A
authors.lastname: Di Fiore
authors.forename: M
authors.initials: M
authors.lastname: Berengo
mesh_terms: D000293:Adolescent; D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D004338:Drug Combinations; D004368:Dry Socket / Q000139:chemically induced* / Q000453:epidemiology; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008963:Molar; D009652:Norpregnenes / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000453:epidemiology; D012307:Risk Factors; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery*; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D009652:Norpregnenes; C494367:estroprogestin; D004997:Ethinyl Estradiol