title: The association between maternal glucose concentration and child BMI at age 3 years.
abstract: OBJECTIVE
  The objective of the study was to determine the association between child BMI at age 3 years and maternal glucose concentration among women without pre-existing diabetes or a gestational diabetes mellitus (GDM) diagnosis.
  
  
  METHODS
  Data are from the Pregnancy Infection and Nutrition and Postpartum studies and include 263 mother-child pairs. Measured weights and heights at 3 years were used to calculate age- and sex-specific BMI z scores and percentiles. Multivariable linear regression models were used to examine associations of continuous BMI z scores with maternal glucose concentration. Modified Poisson regression estimated risk ratios of child overweight/obesity (BMI ≥ 85th percentile).
  
  
  RESULTS
  The mean (SD) maternal glucose concentration and prepregnancy BMI were 103.8 (23.7) mg/dL and 24.3 (5.9) kg/m(2), respectively. At 3 years, the mean (SD) child BMI z score was 0.29 (0.99), 20.9% were overweight/obese and 5.3% were obese. In the adjusted model, when compared with glucose concentration <100 mg/dL, a concentration ≥ 130 mg/dL was associated with significantly higher child BMI z score at 3 years (estimated z score difference of 0.39 [95% CI: 0.03-0.75]). With the use of the same reference category, a concentration ≥ 130 mg/dL was associated with an approximate twofold greater risk of child overweight/obesity (adjusted risk ratio 2.34 [95% CI: 1.25-4.38]).
  
  
  CONCLUSIONS
  Fetal exposure to high maternal glucose concentration in the absence of pre-existing diabetes or GDM may contribute to the development of overweight/obesity in the offspring, independent of maternal prepregnancy BMI.
authors.affiliation: Department of Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA. andrea.deierlein@mssm.edu
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Deierlein
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Siega-Riz
authors.forename: Kim
authors.initials: K
authors.lastname: Chantala
authors.forename: Amy H
authors.initials: AH
authors.lastname: Herring
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002675:Child, Preschool; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009035:Mothers; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology / Q000378:metabolism*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D001786:Blood Glucose