title: Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives.
abstract: A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation reaction of ethylacetoacetate, aromatic aldehyde and ammonium hydroxide. A new series of compounds (2a-g) were prepared from compounds (1a-g) via reaction with thiosemicarbazide using the condensation method. The synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectral and elemental analyses. The synthesized compounds (1a-g) and (2a-g) were also screened for anticoagulant properties.
authors.affiliation: P.G & Research Department of chemistry, Jamal Mohamed College, Tiruchirappalli 620020, Tamil Nadu, India.
authors.forename: R Surendra
authors.initials: RS
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Idhayadhulla
authors.forename: A Jamal
authors.initials: AJ
authors.lastname: Abdul Nasser
authors.forename: J
authors.initials: J
authors.lastname: Selvin
mesh_terms: D000925:Anticoagulants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D012016:Reference Values; D013237:Stereoisomerism
chemical_list: D000925:Anticoagulants; D004095:Dihydropyridines; C038806:1,4-dihydropyridine