title: [Rejection of kidney graft: mechanism and prevention].
abstract: Rejection occurs after the introduction of a genetically different graft, in a recipient. Nowadays, it is still a major obstacle in renal transplantation and reflects a normal protective immune response of a recipient against a foreign antigen. Involving many mechanisms of the innate and adaptive immunity, this reaction results in renal parenchymal lesions witch may progress to graft destruction and loss of its function. Several ways are currently used to reduce the action of the immune system and consequently reduce the risk of rejection. After a presentation of the main actors and the sequence of events leading to rejection, we will describe the strategy used by antirejection teams' transplantation. We will successively consider the prevention (pre-transplant immunological assessment, preventive immunosuppressive therapy), the monitoring (search for antibodies, biopsies) and the treatment.
authors.affiliation: Unité d'immunologie, service de transfusion sanguine et d'hémovigilance de l'hôpital Ibn Sina, CHU de Rabat, Rabat, Maroc. c.brick@chis.ma
authors.forename: Chehrazade
authors.initials: C
authors.lastname: Brick
authors.forename: Ouafa
authors.initials: O
authors.lastname: Atouf
authors.forename: Nadia
authors.initials: N
authors.lastname: Benseffaj
authors.forename: Malika
authors.initials: M
authors.lastname: Essakalli
mesh_terms: D056704:Adaptive Immunity; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation