title: Multicomponent synthesis of poly-substituted benzo[a]pyrano[2,3-c]phenazine derivatives under microwave heating.
abstract: A new one-pot two-step tandem synthesis of highly functionalized benzo[a]pyrano[2,3-c]phenazine derivatives via microwave-assisted multicomponent reactions of 2-hydroxynaphthalene-1,4-dione, diamines, aldehydes, and malononitrile is reported. The procedures are facile, avoiding time-consuming and costly syntheses, tedious workup, and purifications of precursors, as well as protection/deprotection of functional groups. The method is expected to find application in the combinatorial synthesis of biologically active compounds, since phenazine and chromene motifs have a broad spectrum of biological activities.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, P. R. China.
authors.forename: Shu-Liang
authors.initials: SL
authors.lastname: Wang
authors.forename: Fei-Yue
authors.initials: FY
authors.lastname: Wu
authors.forename: Chuang
authors.initials: C
authors.lastname: Cheng
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.forename: Yin-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D006361:Heating; D008872:Microwaves; D015394:Molecular Structure; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D010619:Phenazines; D011714:Pyrans