title: In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm.
abstract: To overcome shortcomings of the ex situ approaches, in situ detection using H(2)O(2) molecules to diagnose ischemia through enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm is demonstrated and it is discovered that the extracellular H(2)O(2) molecule released per ischemic cell is 2.7-times of that of a normal cell.
authors.affiliation: Center for Advanced Bionanosystems and School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore.
authors.forename: Chun Xian
authors.initials: CX
authors.lastname: Guo
authors.forename: Xin Ting
authors.initials: XT
authors.lastname: Zheng
authors.forename: Shu Rui
authors.initials: SR
authors.lastname: Ng
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Lai
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
authors.forename: Chang Ming
authors.initials: CM
authors.lastname: Li
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002374:Catalase / Q000378:metabolism; D055664:Electrochemical Techniques; D004566:Electrodes; D004579:Electron Transport; D006046:Gold / Q000737:chemistry*; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000032:analysis; D053768:Metal Nanoparticles / Q000737:chemistry*; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism*; D053770:Nanowires / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction
chemical_list: D000814:Aniline Compounds; C416807:polyaniline; D006046:Gold; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase; D002374:Catalase