title: [Case of food protein-induced enterocolitis syndrome caused by short-neck clam ingestion].
abstract: A 6-year-old boy was referred for evaluation because he had several vomiting episodes, from the age of 2 years, following short-neck clam ingestion. He tested negative for short-neck clam-specific IgE just before visiting our hospital, and he was not allergic to other foods or shellfish. The patient had low levels of short-neck clam-specific IgE (1.04 UA/ml), and the skin prick test was positive for short-neck clam (4 mm). The lymphocyte stimulation test was positive (5305 counts per min (cpm), stimulation index (SI) =1211%) and the patch test was positive for short-neck clam ingestion. An oral challenge test with boiled short-neck clam induced abdominal pain and vomiting 2 h after ingestion, and the patient presented with increased peripheral leukocytes after 6 h. He was therefore diagnosed with food protein-induced enterocolitis syndrome (FPIES) due to short-neck clam ingestion. To our knowledge, this is the first case report of FPIES induced by the intake of shellfish.
authors.affiliation: Tsukuba Medical Center Hospital. d-hayashi@tmch.or.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Rumiko
authors.initials: R
authors.lastname: Shibata
authors.forename: Kunio
authors.initials: K
authors.lastname: Ichikawa
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D049872:Bivalvia / Q000276:immunology*; D002648:Child; D004760:Enterocolitis / Q000175:diagnosis* / Q000276:immunology*; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008213:Lymphocyte Activation; D008297:Male; D010328:Patch Tests; D012758:Shellfish; D013577:Syndrome
chemical_list: D015415:Biomarkers; D007073:Immunoglobulin E