title: Planar block copolymer membranes by vesicle spreading.
abstract: An easy route to planar solid-supported polymer membranes by vesicle spreading is described. Pre-organized poly(butadiene)-block-poly(ethylene oxide)(PB-PEO) assemblies were spread on two different supports, i.e. strongly hydrophilic glass surfaces and ultrasmooth gold substrates. Polymer membranes were produced on a hydrophilic support by spreading hydroxyl-functionalized polymer vesicles, while covalently immobilized polymer membranes were obtained by spreading LA-functionalized polymer vesicles on gold substrates. Covalently bound membranes were further incubated with the peptide polymyxin B. Interactions with the polymer membrane were detected by EIS. These systems are of great interest to fundamental membrane science and have potential in technological applications, such as drug screening and (bio)sensing.
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Dorn
authors.forename: Serena
authors.initials: S
authors.lastname: Belegrinou
authors.forename: Max
authors.initials: M
authors.lastname: Kreiter
authors.forename: Eva-Kathrin
authors.initials: EK
authors.lastname: Sinner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Meier
mesh_terms: D015374:Biosensing Techniques / Q000379:methods; D002070:Butadienes / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006046:Gold / Q000737:chemistry*; D008567:Membranes, Artificial; D020959:Polyethylene / Q000737:chemistry*; D011112:Polymyxin B / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D002070:Butadienes; D008567:Membranes, Artificial; C473741:poly(1,2-butadiene-b-ethylene oxide); D006046:Gold; D020959:Polyethylene; D011112:Polymyxin B