title: Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial.
abstract: OBJECTIVE
  To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.
  
  
  METHODS
  In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.
  
  
  RESULTS
  The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P=0.94). The day 7-day 1 factor II, R(-) and S(-) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P=0.81, P=0.45, P=0.75, respectively).
  
  
  CONCLUSIONS
  Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.
authors.affiliation: University of Paris VII-Denis Diderot, Therapeutic Research Unit, Department of Internal Medicine, Lariboisière Hospital, Paris, France.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guy
authors.initials: G
authors.lastname: Simoneau
authors.forename: Celine
authors.initials: C
authors.lastname: Verstuyft
authors.forename: Ludovic
authors.initials: L
authors.lastname: Drouet
authors.forename: Claire
authors.initials: C
authors.lastname: Bal dit Sollier
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Alvarez
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rizzo-Padoin
authors.forename: Jean Francois
authors.initials: JF
authors.lastname: Bergmann
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mouly
mesh_terms: D000328:Adult; D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000925:Anticoagulants / Q000097:blood / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D011516:Prothrombin / Q000378:metabolism; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D014859:Warfarin; D019980:Amoxicillin-Potassium Clavulanate Combination; D011516:Prothrombin