title: Carijodienone from the octocoral Carijoa multiflora. A spiropregnane-based steroid.
abstract: Two new steroids (1 and 2) and the known pregna-1,4,20-trien-3-one (3) have been isolated from the Pacific octocoral Carijoa multiflora. Compound 1 possesses a novel spiropregnane-based steroidal skeleton. The photochemical transformation of 3 into 1 allowed the assignment of the absolute configuration at C-10 of 1. The antibacterial activities of compounds 1 and 3 were evaluated against a panel of bacterial strains.
authors.affiliation: Instituto de Productos Naturales y Agrobiología del CSIC, Avenida Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain. ardiaz@ipna.csic.es
authors.forename: Ana R
authors.initials: AR
authors.lastname: Díaz-Marrero
authors.forename: Gina
authors.initials: G
authors.lastname: Porras
authors.forename: Zulma
authors.initials: Z
authors.lastname: Aragón
authors.forename: José M
authors.initials: JM
authors.lastname: de la Rosa
authors.forename: Enrique
authors.initials: E
authors.lastname: Dorta
authors.forename: Mercedes
authors.initials: M
authors.lastname: Cueto
authors.forename: Luis
authors.initials: L
authors.lastname: D'Croz
authors.forename: Juan
authors.initials: J
authors.lastname: Maté
authors.forename: José
authors.initials: J
authors.lastname: Darias
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011513:Proteus mirabilis / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013256:Steroids; C557518:carijodienone