title: [Progress of peripheral nerve defect treatment with tissue engineering].
abstract: OBJECTIVE
  To review new progress of related research of peripheral nerve defect treatment with tissue engineering in recent years.
  
  
  METHODS
  Domestic and international literature concerning peripheral nerve defect treatment with tissue engineering was reviewed and analyzed.
  
  
  RESULTS
  Releasing neurotrophic factors with sustained release technology included molecular biology techniques, poly (lactic-co-glycolic acid) microspheres, and polyphosphate microspheres. The mixture of neurotrophic factors and ductus was implanted to the neural tube wall which could be degraded then releasing factors slowly. Seed cells which were the major source of active ingredients played an important role in the repair and reconstruction of tissue engineering products. The neural tube of Schwann cells made long nerve repair and the quality of nerve regeneration was improved. Nerve scaffold materials included natural and synthetic biodegradable materials. Tube structure usually was adopted for nerve scaffold, which performance would affect the nerve repair effects directly.
  
  
  CONCLUSIONS
  With the further research of tissue engineering, the treatment of peripheral nerve defects with tissue engineering has made significant progress.
authors.affiliation: Department of Orthopaedics and Traumatology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P R China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhandong
authors.initials: Z
authors.lastname: Bo
mesh_terms: D000818:Animals; D009414:Nerve Growth Factors; D009416:Nerve Regeneration; D010525:Peripheral Nerves / Q000601:surgery*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D009414:Nerve Growth Factors