title: Assessment of consciousness with electrophysiological and neurological imaging techniques.
abstract: OBJECTIVE
  Brain MRI (diffusion tensor imaging and spectroscopy) and functional neuroimaging (PET, functional MRI, EEG and evoked potential studies) are changing our understanding of patients with disorders of consciousness encountered after coma such as the 'vegetative' or minimally conscious states.
  
  
  RESULTS
  Increasing evidence from functional neuroimaging and electrophysiology demonstrates some residual cognitive processing in a subgroup of patients who clinically fail to show any response to commands, leading to the recent proposal of 'unresponsive wakefulness syndrome' as an alternative name for patients previously coined 'vegetative' or 'apallic'.
  
  
  CONCLUSIONS
  Consciousness can be viewed as the emergent property of the collective behavior of widespread thalamocortical frontoparietal network connectivity. Data from physiological, pharmacological and pathological alterations of consciousness provide evidence in favor of this hypothesis. Increasing our understanding of the neural correlates of consciousness is helping clinicians to do a better job in terms of diagnosis, prognosis and finally treatment and drug development for these severely brain-damaged patients. The current challenge remains to continue translating this research from the bench to the bedside. Only well controlled large multicentric neuroimaging and electrophysiology studies will enable to identify which paraclinical diagnostic or prognostic test is necessary for our routine evidence-based assessment of individuals with disorders of consciousness.
authors.affiliation: Coma Science Group, Cyclotron Research Centre, University of Liège, Belgium.
authors.forename: Marie-Aurélie
authors.initials: MA
authors.lastname: Bruno
authors.forename: Olivia
authors.initials: O
authors.lastname: Gosseries
authors.forename: Didier
authors.initials: D
authors.lastname: Ledoux
authors.forename: Roland
authors.initials: R
authors.lastname: Hustinx
authors.forename: Steven
authors.initials: S
authors.lastname: Laureys
mesh_terms: D003943:Diagnostic Techniques, Neurological; D004569:Electroencephalography; D006801:Humans; D014474:Unconsciousness / Q000175:diagnosis*