title: Prognostic value of first IVF cycle on success of a subsequent cycle.
abstract: OBJECTIVE
  To determine whether a live birth or miscarriage in a previous IVF cycle is predictive of success in a subsequent cycle.
  
  
  METHODS
  Retrospective study
  
  
  METHODS
  Private IVF unit
  
  
  METHODS
  1141 couples having a second IVF cycle.
  
  
  METHODS
  3 groups; Group I: women who had a live birth in the first cycle, Group II those who had a miscarriage, Group III, women who had a negative pregnancy test in their first cycle.
  
  
  METHODS
  Pregnancy (PR), Live birth (LBR) & miscarriage rates in the second cycle.
  
  
  RESULTS
  For women < than 40: PR was 46.4% (368/793), miscarriage rate was 29.9% and the LBR was 32.5% (258/793). Women in groups I & II had a statistically higher PR than those in group III 63.3% v 55.2% v 41.9% respectively. LBR was higher 45% v 37.8 v 29.6% respectively. Miscarriage rate was similar. For women 40 years and older: The PR was 21.0% (73/348), miscarriage rate was 52.1% (38/73) and the LBR was 10.1% (35/348).There was no significant difference in PR among women in groups I, II & III. The LBR and miscarriage rates were similar in all groups.
  
  
  CONCLUSIONS
  Young women who had a live birth and those who experienced an early miscarriage after IVF have a greater likelihood of achieving a live birth in a second cycle. Outcome of first IVF cycle however does not predict subsequent IVF success in older women.
authors.affiliation: Queen Mary's Hospital, Kingston Hospital NHS Trust, Kingston Upon Thames, Surrey, UK, KT2 7QB. ekalu@doctors.org.uk
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Kalu
authors.forename: Meen-Yau
authors.initials: MY
authors.lastname: Thum
authors.forename: Hossam
authors.initials: H
authors.lastname: Abdalla
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D005544:Forecasting; D006801:Humans; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D013223:Statistics as Topic; D016896:Treatment Outcome