title: Mitochondrial stress signals revise an old aging theory.
abstract: In this issue, Durieux et al. (2011) describe a tissue-specific signal, originating from mitochondria, that acts cell non-autonomously to regulate life span in the nematode, C. elegans. This new finding provides a first step toward resolving the relative contributions of mitochondrial free radical damage and signaling mechanisms in aging.
authors.affiliation: Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA.
authors.forename: Dong Kyun
authors.initials: DK
authors.lastname: Woo
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Shadel