title: Morphofunctional analysis of experimental model of esophageal achalasia in rats.
abstract: We carried out a detailed analysis of rat model of esophageal achalasia previously developed by us. Manifest morphological and functional disorders were observed in experimental achalasia: hyperplasia of the squamous epithelium, reduced number of nerve fibers, excessive growth of fibrous connective tissue in the esophageal wall, high contractile activity of the lower esophageal sphincter, and reduced motility of the longitudinal muscle layer. Changes in rat esophagus observed in experimental achalasia largely correlate with those in esophageal achalasia in humans. Hence, our experimental model can be used for the development of new methods of disease treatment.
authors.affiliation: Kazan State Medical University, Kazan, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Sabirov
authors.forename: I S
authors.initials: IS
authors.lastname: Raginov
authors.forename: M V
authors.initials: MV
authors.lastname: Burmistrov
authors.forename: Y A
authors.initials: YA
authors.lastname: Chelyshev
authors.forename: R Sh
authors.initials: RSh
authors.lastname: Khasanov
authors.forename: A A
authors.initials: AA
authors.lastname: Moroshek
authors.forename: P N
authors.initials: PN
authors.lastname: Grigoriev
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
authors.forename: M A
authors.initials: MA
authors.lastname: Mukhamedyarov
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004931:Esophageal Achalasia / Q000473:pathology / Q000503:physiopathology*; D049630:Esophageal Sphincter, Lower / Q000503:physiopathology; D004947:Esophagus / Q000473:pathology / Q000503:physiopathology; D009119:Muscle Contraction; D051381:Rats