title: [Successful treatment of advanced esophageal cancer with lymph node metastases by docetaxel, cisplatin and 5-FU followed by salvage lymphadenectomy--a case report].
abstract: We present a case of advanced esophageal cancer with multiple lymph node metastases successfully treated by combination therapy of docetaxel, cisplatin and 5-FU (DCF) followed by salvage lymphadenectomy. The patient was a 60-year-old female with the diagnosis of squamous cell carcinoma of the middle thoracic esophagus. The clinical stage diagnosis was cT2N4M0, cStage IVa. Systemic chemotherapy with DCF was started as the initial treatment. The changes noted on endoscopy and CT scan in the primary lesion and lymph nodes after two cycles of DCF were judged as complete response (CR). However, recurrence was diagnosed in the left cervical lymph nodes based on FDG uptake on FDG-PET. Salvage cervical lymphadenectomy was performed. Thereafter, the patient again achieved CR after the second administration of DCF for upper mediastinal lymph node recurrence. At present, she is still alive three years after the first visit. Combination therapy of DCF and salvage lymphadenectomy is potentially effective for advanced esophageal cancer with lymph node metastases.
authors.affiliation: Dept. of Gastroenterological Surgery, Kansai Rosai Hospital.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeno
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tamura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Miki
authors.forename: Hisako
authors.initials: H
authors.lastname: Ono
authors.forename: Chieko
authors.initials: C
authors.lastname: Uchiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kanemura
authors.forename: Ayako
authors.initials: A
authors.lastname: Yanai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Rei
authors.initials: R
authors.lastname: Suzuki
authors.forename: Shin
authors.initials: S
authors.lastname: Nakahira
authors.forename: Ken
authors.initials: K
authors.lastname: Nakata
authors.forename: Shu
authors.initials: S
authors.lastname: Okamura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D016879:Salvage Therapy; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin