title: Capsinoids, non-pungent capsaicin analogs, reduce body fat accumulation without weight rebound unlike dietary restriction in mice.
abstract: Enhancing energy expenditure and reducing energy intake are both crucial for weight control. Capsinoids, which are non-pungent capsaicin analogs, are known to suppress body fat accumulation and reduce body weight by enhancing energy expenditure in both mice and humans. However, it is poorly understood whether the suppression of body fat accumulation by capsinoids has an advantage over dietary restriction. This study shows that the oxygen consumption was increased in mice administered with capsinoids but not in dietary-restricted mice, although there was a similar suppression of body fat accumulation in both groups. The weight rebound was more notable in the dietary-restricted mice than in the mice administered with capsinoids. These results indicate that suppressing body fat accumulation by capsinoids was more beneficial than a restricted diet for maintaining body weight.
authors.affiliation: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Haramizu
authors.forename: Fuminori
authors.initials: F
authors.lastname: Kawabata
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Masuda
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ohnuki
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Watanabe
authors.forename: Susumu
authors.initials: S
authors.lastname: Yazawa
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002211:Capsaicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004032:Diet; D004734:Energy Metabolism / Q000187:drug effects; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
chemical_list: D014280:Triglycerides; C470213:capsiate; D002211:Capsaicin