title: Bireticulol, a bioactive isocoumarin dimer from Streptomyces sp. BCC24731.
abstract: A new dimeric isocoumarin, bireticulol, was isolated from the terrestrial Streptomyces sp. and characterized as a 5-5' dimer of reticulol. In addition, reticulol and 8-hydroxy-6,7-dimethoxy-3-methyl isocoumarin, together with other known polyketides piericidin A, 2'-(2-hydroxyphenyl)-2,4'-bibenzoxazole-4-carboxylic acid methyl ester (UK-1) and 3-benzyl-4-hydroxy-5-methyldihydrofuran-2-one were also obtained. Bireticulol exhibited cytotoxic effects against KB (human epidermoid carcinoma, ATCC CCL-17) and NCI-H187 (human small cell lung cancer, ATCC CRL-5804) cell lines with IC(50) values of 24.4 and 8.31  μg  ml(-1), respectively.
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong 1, Klong Luang, Pathumthani, Thailand. chollaratt.boo@biotec.or.th
authors.forename: Chollaratt
authors.initials: C
authors.lastname: Boonlarppradab
authors.forename: Chanwit
authors.initials: C
authors.lastname: Suriyachadkun
authors.forename: Sumalee
authors.initials: S
authors.lastname: Suphothina
authors.forename: Punsa
authors.initials: P
authors.lastname: Tobwor
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D006801:Humans; D049934:Isocoumarins / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D014709:Vero Cells / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D049934:Isocoumarins; C558373:bireticulol