title: Isolated spinal cord neurosarcoidosis diagnosed by cord biopsy and thalidomide trial.
abstract: We report a case of 54-yr-old woman who presented with 4-extremities weakness and sensory changes, followed by cervical spinal cord lesion in magnetic resonance imaging. Based on the suspicion of spinal tumor, spinal cord biopsy was performed, and the histology revealed multinucleated giant cells, lymphocytes and aggregated histiocytes within granulomatous inflammation, consistent with non-caseating granuloma seen in sarcoidosis. The patient was treated with corticosteroid, immunosuppressant and thalidomide for years. Our case indicates that diagnosis of spinal cord sarcoidosis is challenging and may require histological examination, and high-dose corticosteroid and immunosuppressant will be a good choice in the treatment of spinal cord sarcoidosis, and the thalidomide has to be debated in the spinal cord sarcoidosis.
authors.affiliation: Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Suk-Won
authors.initials: SW
authors.lastname: Ahn
authors.forename: Kyoung-Tae
authors.initials: KT
authors.lastname: Kim
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Youn
authors.forename: Oh-Sang
authors.initials: OS
authors.lastname: Kwon
authors.forename: Young-Baeg
authors.initials: YB
authors.lastname: Kim
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001706:Biopsy; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012507:Sarcoidosis / Q000188:drug therapy / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000188:drug therapy / Q000473:pathology*; D013792:Thalidomide / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D013792:Thalidomide