title: Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines.
abstract: A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines. This highly regioselective and one-pot process provides rapid access to highly diverse triazoles.
authors.affiliation: Discovery Chemistry Group, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA. castanedo.georgette@gene.com
authors.forename: Georgette M
authors.initials: GM
authors.lastname: Castanedo
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Seng
authors.forename: Nicole
authors.initials: N
authors.lastname: Blaquiere
authors.forename: Sean
authors.initials: S
authors.lastname: Trapp
authors.forename: Steven T
authors.initials: ST
authors.lastname: Staben
mesh_terms: D000578:Amidines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D000578:Amidines; D002264:Carboxylic Acids; D006834:Hydrazines; D014230:Triazoles