title: SNARE proteins underpin insulin-regulated GLUT4 traffic.
abstract: Delivery of the glucose transporter type 4 (GLUT4) from an intracellular location to the cell surface in response to insulin represents a specialized form of membrane traffic, known to be impaired in the disease states of insulin resistance and type 2 diabetes. Like all membrane trafficking events, this translocation of GLUT4 requires members of the SNARE family of proteins. Here, we discuss two SNARE complexes that have been implicated in insulin-regulated GLUT4 traffic: one regulating the final delivery of GLUT4 to the cell surface in response to insulin and the other controlling GLUT4's intracellular trafficking.
authors.affiliation: Henry Wellcome Laboratory of Cell Biology, Institute of Molecular, Cell and Systems Biology, Davidson Building, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Nia J
authors.initials: NJ
authors.lastname: Bryant
authors.forename: Gwyn W
authors.initials: GW
authors.lastname: Gould
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D008561:Membrane Fusion / Q000502:physiology; D051938:Munc18 Proteins / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D050600:SNARE Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D051275:Glucose Transporter Type 4; D007328:Insulin; D051938:Munc18 Proteins; D020033:Protein Isoforms; D050600:SNARE Proteins