title: Improvements in population-based survival of patients presenting with metastatic rectal cancer in the south of the Netherlands, 1992-2008.
abstract: We analysed population-based treatment and survival data of patients who presented with metastatic rectal cancer. All patients diagnosed with primary synchronous metastatic rectal cancer between 1992 and 2008 in the Eindhoven Cancer Registry area were included. Date of diagnosis was divided into three periods (1992-1999, 2000-2004, 2005-2008) according to the availability of chemotherapy type. We assessed treatment patterns and overall survival according to period of diagnosis. The proportion of patients diagnosed with stage IV disease increased from 16% in 1992-1999 to 20% in 2005-2008 (P < 0.0001). Chemotherapy use increased from 5% in 1992 to 61% in 2008 (P < 0.0001). Resection rates of the primary tumour decreased from 65% in 1992 to 27% in 2008 (P < 0.0001), while metastasectomy rates remained constant since 1999 (9%). Median survival increased from 38 weeks (95% confidence interval (CI) 32-44) in 1992-1999 to 53 weeks (95% CI 48-61) in 2005-2008. Among patients not receiving chemotherapy median survival remained approximately 30 weeks. Multivariable analysis confirmed the lower risk of death among patients diagnosed in more recent years. Increased use of chemotherapy went together with improved median survival among patients with metastatic rectal cancer in the last two decades. Stage migration as an effect of more effective imaging procedures is likely to be partly responsible for this improved survival.
authors.affiliation: Department of Research, Comprehensive Cancer Centre South, Eindhoven, The Netherlands. v.lemmens@ikz.nl
authors.forename: V E P P
authors.initials: VE
authors.lastname: Lemmens
authors.forename: N
authors.initials: N
authors.lastname: de Haan
authors.forename: H J T
authors.initials: HJ
authors.lastname: Rutten
authors.forename: H
authors.initials: H
authors.lastname: Martijn
authors.forename: O J L
authors.initials: OJ
authors.lastname: Loosveld
authors.forename: R M H
authors.initials: RM
authors.lastname: Roumen
authors.forename: G J M
authors.initials: GJ
authors.lastname: Creemers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000266:history / Q000401:mortality; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000266:history / Q000401:mortality / Q000601:surgery*; D012042:Registries; D016019:Survival Analysis; D016896:Treatment Outcome