title: [Effects of Bai-Chuan capsule on left ventricular hypertrophy and correlative indexes].
abstract: OBJECTIVE
  To investigate the effects of Bai-Chuan capsule (BC) on the left ventricular hypertrophy in spontaneously hypertensive rats (SHR).
  
  
  METHODS
  Taking SHR and Wistar Kyoto rats (WKY) as the model group and the control group respectively, Captopril as positive drug, administered BC 0.3 g/kg, Captopril 3.75 mg/kg or 0.5% CMC-Na to each group by ig for 3 months, and measured the change of blood pressure. The left ventricular mass index was calculated after rats were sacrificed. Left ventricle was used to pathological observations, plasma angiotensin II and aldosterone were measured by radioimmunoassay.
  
  
  CONCLUSIONS
  BC can inhibit left ventricular hypertrophy, plasma level of angiotensin II and aldosterone to some extent in SHR.
authors.affiliation: School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. classicyan@gmail.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lang-chong
authors.initials: LC
authors.lastname: He
authors.forename: Hai-jie
authors.initials: HJ
authors.lastname: Duan
authors.forename: Ying-zhuan
authors.initials: YZ
authors.lastname: Zhan
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects; D002214:Capsules; D002216:Captopril / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006352:Heart Ventricles / Q000187:drug effects / Q000473:pathology; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D009206:Myocardium / Q000473:pathology; D011863:Radioimmunoassay; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D000959:Antihypertensive Agents; D002214:Capsules; D004365:Drugs, Chinese Herbal; D000804:Angiotensin II; D000450:Aldosterone; D002216:Captopril