title: Sodium thiosulfate not always resolves calciphylaxis: an ambiguous response.
abstract: Calciphylaxis is a severe "vascular ossification-calcification," associated with a very high mortality rate that involves arterial wall, venular wall, and nerves resulting in ischemia and necrosis of skin, subcutaneous fat, visceral organs, and skeletal muscles. Sodium thiosulfate has recently been used as a novel treatment option for calciphylaxis because of its dual role as an antioxidant and a chelator. Multiple case reports demonstrated that such therapy has resulted in pain relief and healing of skin ulceration. We report a case of calciphylaxis of large severity that had an ambiguous response to sodium thiosulfate treatment (improvement of symptomatology and skin lesions, improvement of blood parameters, worsening of general conditions, and consciousness until death).
authors.affiliation: Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Miceli
authors.forename: Glauco
authors.initials: G
authors.lastname: Milio
authors.forename: Sergio
authors.initials: S
authors.lastname: La Placa
authors.forename: Domenico
authors.initials: D
authors.lastname: Di Raimondo
authors.forename: Antonino
authors.initials: A
authors.lastname: Tuttolomondo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Li Vecchi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Licata
authors.forename: Antonio
authors.initials: A
authors.lastname: Pinto
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002115:Calciphylaxis / Q000188:drug therapy*; D002614:Chelating Agents / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D012720:Severity of Illness Index; D013885:Thiosulfates / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D002614:Chelating Agents; D013885:Thiosulfates; C017717:sodium thiosulfate