title: Blood, urine, and hair kinetic analysis following an acute lead intoxication.
abstract: A case of lead exposure resulting from the accidental ingestion of a lead-containing solution is reported. Because of clinical management rapidly performed through chelation therapy by 2,3-dimercaptopropane sulfonate sodium and meso-2,3-dimercaptosuccinic acid, blood lead levels of this 51-year-old patient were moderate (412.9 μg/L) and no clinical symptoms were observed. Numerous blood and urine samples were collected for kinetic analysis of lead elimination. However, we report the first case in which hair samples were analyzed to determine the excretion level of lead after acute intoxication.
authors.affiliation: Service de Toxicologie Clinique, Médicolégale, Environnementale et en Entreprise, Centre Interfacultaire de Recherche du Médicament, ULg, Centre Hospitalier Universitaire Sart-Tilman B35, B-4000 Liège, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Ho
authors.forename: A
authors.initials: A
authors.lastname: Keutgens
authors.forename: R
authors.initials: R
authors.lastname: Schoofs
authors.forename: S
authors.initials: S
authors.lastname: Kotolenko
authors.forename: R
authors.initials: R
authors.lastname: Denooz
authors.forename: C
authors.initials: C
authors.lastname: Charlier
mesh_terms: D002614:Chelating Agents / Q000627:therapeutic use; D015913:Chelation Therapy / Q000379:methods; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D007854:Lead / Q000097:blood* / Q000652:urine*; D007855:Lead Poisoning / Q000175:diagnosis; D008875:Middle Aged; D004113:Succimer / Q000627:therapeutic use*; D014494:Unithiol / Q000627:therapeutic use*
chemical_list: D002614:Chelating Agents; D007854:Lead; D014494:Unithiol; D004113:Succimer