title: [CuZn-SOD and MDA in the serum and EPS of chronic prostatitis patients: quantitative determination and analysis].
abstract: OBJECTIVE
  Chronic prostatitis (CP) is a common disease in adult males. Oxidative stress injury has been found to play a significant role in the pathogenesis of CP in recent studies. This study aimed to determine the contents of CuZn-super oxide dismutase (CuZn-SOD) and malondialdehyde (MDA) in the serum and EPS in CP patients and healthy men, and investigate their significance in the diagnosis and treatment of the CP.
  
  
  METHODS
  A total of 120 out-patients with confirmed CP were equally divided into a type II, a type IIIA and a type IIIB group, and another 40 healthy males were included as controls. We determined the contents of CuZn-SOD and MDA in the serum and EPS of each group and compared their differences.
  
  
  RESULTS
  No significant differences were found in the serum CuZn-SOD content among the four groups (P > 0.05). The MDA contents were markedly higher in the CP groups than in the control (P < 0.01), but with no significant differences among the three CP groups (P > 0.05). The CuZn-SOD contents in EPS were remarkably lower in the type II and type III A than in the type III B and control groups (P < 0.01), but with no significant differences between the type II and type III A as well as between the type III B and control groups (P > 0.05). The MDA contents in EPS were markedly higher in the type II and type III A than in the type III B and control groups (P < 0.01), but with no significant differences between the type II and type III A as well as the type III B and control groups (P > 0.05).
  
  
  CONCLUSIONS
  Oxidative stress is stronger in type II and type III A CP patients than in healthy men, but has no significant difference between type III B patients and non-CP males. Determining the contents of CuZn-SOD and MDA in the serum and EPS could be very valuable for the diagnosis and assessment of chronic prostatitis.
authors.affiliation: Department of Urology, Qingdao Municipal Hospital, Qingdao, Shandong 266011, China. housichuan@yahoo.cn
authors.forename: Si-Chuan
authors.initials: SC
authors.lastname: Hou
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Ai
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Gao
authors.forename: Hai
authors.initials: H
authors.lastname: Zhu
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Sun
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood* / Q000378:metabolism; D018384:Oxidative Stress; D011472:Prostatitis / Q000097:blood* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood* / Q000378:metabolism
chemical_list: D008315:Malondialdehyde; D013482:Superoxide Dismutase