title: Relationship of the protein Z intron F G79A and IL6 C634G gene polymorphisms with the risk of recurrent pregnancy loss in Egyptian women.
abstract: OBJECTIVE
  To investigate the relationship between recurrent pregnancy loss and single nucleotide polymorphisms in the protein Z (PZ) intron F G79A and the promoter region of the IL6 C634G genes in Egyptian women.
  
  
  METHODS
  Single nucleotide polymorphisms in the PZ intron F G79A gene and the promoter region of the IL6 C634G gene were studied in 70 Egyptian women; 40 patients and 30 healthy and parous volunteers using the polymerase chain reaction-restriction fragment length polymorphism technique.
  
  
  RESULTS
  Regarding the PZ intron F G79A polymorphism; a higher prevalence of the A allele in the controls (53.3%) compared with the cases (22.5%) was found, and the difference proved to be statistically significant (P = 0.008). As for the IL6 C634G polymorphism, the frequency of the G allele was higher in the controls (100%) than in the cases (95%), but the difference did not prove to be statistically significant (P = 0.503). A statistically significant difference between the prevalence of the IL6 C634G (95%) and the PZ intron F G79A (22.5%) was detected (P ≤ 0.001).
  
  
  CONCLUSIONS
  A statistically significant difference of the frequency of the A allele of the PZ intron F G79A polymorphism was found with a higher prevalence of the A allele among the controls compared with the patients, suggesting a lower risk of recurrent pregnancy loss among the studied patients, but the IL6 C634G polymorphism did not prove to have an equivalent effect.
authors.affiliation: Department of Clinical Pathology, Kasr El-Aini, Cairo University, Manial EL-Rouda, Egypt. samah_cpath@yahoo.com
authors.forename: Samah Abd
authors.initials: SA
authors.lastname: El-Hamid
authors.forename: Waleed
authors.initials: W
authors.lastname: El-Khayat
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000235:genetics* / Q000378:metabolism; D004534:Egypt / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D007438:Introns; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D015850:Interleukin-6; C026080:plasma protein Z