title: Monte Carlo simulation of radial distribution of DNA strand breaks along the C and Ne ion paths.
abstract: Radial energy deposition distribution, the distribution of DNA strand breaks and their yields were simulated by Monte Carlo track structure simulation for C and Ne ions with the same linear energy transfer (LET) around 450 keV/μm. The radial DNA damage distribution shows different pattern for C and Ne ions. Double strand break (DSB) are mostly formed in the central area, while the single strand break (SSB) tends to spread to the surrounding area. It is also shown that the production efficiency of the SSB and DSB depends on the radial distance. This result shows reasonable agreement with the recently obtained experimental observation, which indicates that different types of DNA damage shows different distribution patterns around C and Ne ion paths in cell nuclei.
authors.affiliation: Japan Atomic Energy Agency, Tokai, Ibaraki 319-1195, Japan. watanabe.ritsuko@jaea.go.jp
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Watanabe
authors.forename: Seiichi
authors.initials: S
authors.lastname: Wada
authors.forename: Tomoo
authors.initials: T
authors.lastname: Funayama
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Saito
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Furusawa
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry; D003198:Computer Simulation; D004247:DNA / Q000235:genetics* / Q000528:radiation effects*; D004249:DNA Damage / Q000502:physiology*; D020450:Heavy Ions; D006801:Humans; D018499:Linear Energy Transfer / Q000502:physiology; D008956:Models, Chemical; D015233:Models, Statistical; D009010:Monte Carlo Method; D009356:Neon / Q000737:chemistry; D016008:Statistical Distributions
chemical_list: D009356:Neon; D002244:Carbon; D004247:DNA