title: A highly convergent cascade cyclization to cis-hydrindanes with all-carbon quaternary centers and its application in the synthesis of the aglycon of dendronobiloside A.
abstract: An efficient and versatile ZnBr(2)-catalyzed Diels-Alder/carbocyclization cascade reaction has been developed for construction of highly functionalized cis-hydrindanes (70-96% yields with high diastereoselectivity), and it has been successfully utilized in the synthesis of the aglycon of dendronobiloside A.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China.
authors.forename: Yejian
authors.initials: Y
authors.lastname: Han
authors.forename: Lizhi
authors.initials: L
authors.lastname: Zhu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Chi-Sing
authors.initials: CS
authors.lastname: Lee
mesh_terms: D001965:Bromides / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D001965:Bromides; D005960:Glucosides; D007189:Indans; D012717:Sesquiterpenes; D017967:Zinc Compounds; C438414:dendronobiloside A; C531997:hydrindane; D002244:Carbon; C093802:zinc bromide