title: Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor.
abstract: BACKGROUND
  Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome-wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET.
  
  
  METHODS
  We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain.
  
  
  RESULTS
  We were unable to replicate the association between LINGO1 variants and familial ET.
  
  
  CONCLUSIONS
  Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.
authors.affiliation: Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Lorenzo-Betancor
authors.forename: E
authors.initials: E
authors.lastname: García-Martín
authors.forename: S
authors.initials: S
authors.lastname: Cervantes
authors.forename: J A G
authors.initials: JA
authors.lastname: Agúndez
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: H
authors.initials: H
authors.lastname: Alonso-Navarro
authors.forename: A
authors.initials: A
authors.lastname: Luengo
authors.forename: F
authors.initials: F
authors.lastname: Coria
authors.forename: E
authors.initials: E
authors.lastname: Lorenzo
authors.forename: J
authors.initials: J
authors.lastname: Irigoyen
authors.forename: P
authors.initials: P
authors.lastname: Pastor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D020329:Essential Tremor / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins