title: The Americleft study: an inter-center study of treatment outcomes for patients with unilateral cleft lip and palate part 5. General discussion and conclusions.
abstract: OBJECTIVE
  To summarize the Americleft study regarding treatment outcomes for patients with complete unilateral cleft lip and palate (CUCLP).
  
  
  METHODS
  Five cleft palate centers in North America.
  
  
  METHODS
  One hundred sixty-nine subjects, between the ages of 6 years and 12 years, with repaired CUCLP who were consecutively treated at the five centers.
  
  
  METHODS
  Study consisted of model comparisons assessing maxillomandibular relationship using the GOSLON Yardstick (169 patients from all 5 centers), soft and hard tissue craniofacial morphologic comparisons using lateral cephalometric analyses (148 patients from four of the centers), and nasolabial esthetics assessments (125 patients from four of the centers).
  
  
  RESULTS
  Significant differences were found between the center with the best GOSLON scores and the remaining centers. These differences also corresponded to those found in the craniofacial morphologic cephalometric assessment. Sagittal maxillary prominence was found to be significantly better for the center with the best GOSLON scores, while no significant differences were seen among the centers for mandibular prominence, vertical dimensions, or dental inclinations. No differences were seen for nasolabial esthetics between the centers.
  
  
  CONCLUSIONS
  Challenges experienced while undertaking the inter-center retrospective study are reviewed. Aspects of treatment that could potentially make the outcome of treatment less optimal included primary alveolar bone grafting and extensive treatment protocols. Differences in the outcomes identified between the centers were restricted to the maxilla, and no differences were identified for mandibular prominence, vertical dimensions, or dental inclinations.
authors.affiliation: Division of Orthodontics, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada. Kathy.Russell@Dal.ca
authors.forename: Kathleen
authors.initials: K
authors.lastname: Russell
authors.forename: Ross E
authors.initials: RE
authors.lastname: Long
authors.forename: Ronald
authors.initials: R
authors.lastname: Hathaway
authors.forename: John
authors.initials: J
authors.lastname: Daskalogiannakis
authors.forename: Ana
authors.initials: A
authors.lastname: Mercado
authors.forename: Marilyn
authors.initials: M
authors.lastname: Cohen
authors.forename: Gunvor
authors.initials: G
authors.lastname: Semb
authors.forename: William
authors.initials: W
authors.lastname: Shaw
mesh_terms: D002648:Child; D002971:Cleft Lip / Q000453:epidemiology / Q000601:surgery*; D002972:Cleft Palate / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009656:North America / Q000453:epidemiology; D017063:Outcome Assessment, Health Care; D012107:Research Design