title: Mechanism underlying silent cleanup of apoptotic cells.
abstract: Apoptotic cells are cleared without an inflammatory response such as neutrophil infiltration. The mechanism underlying such silent cleanup of apoptotic cells has been intensively investigated in vitro for over a decade, and the concept that active suppression via IL-10, TGF-β, and nitric oxide enables such silent cleanup to occur has been emerging. However, because this concept has not been vigorously examined under a variety of experimental conditions in vivo, the possibility remains that a null response, in which neither cytokines nor nitric oxide is produced upon an encounter with apoptotic cells, is responsible for silent cleanup.
authors.affiliation: Division of Molecular Medicine, Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Japan. yoshiro@biomol.sci.toho-u.ac.jp
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D017209:Apoptosis; D016207:Cytokines / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology; D020556:Neutrophil Infiltration
chemical_list: D016207:Cytokines