title: [The influence of human immunodeficiency virus co-infection with hepatitis C virus and hepatitis B virus on the efficacy of high active anti-retroviral therapy].
abstract: OBJECTIVE
  To evaluate the impact of HIV co-infection with HCV or HBV on the efficacy of highly active anti-retroviral therapy (HARRT).
  
  
  METHODS
  The patients were divided into three groups: HIV + HBV + HCV co-infection group (23 patients), HIV + HCV co-infection group (166 patients), and HIV-only group (178 patients). HIV RNA, HCV RNA or HBV DNA were detected by real time PCR before treatment and 1, 3, 6, 9 and 12 months after treatment, meanwhile the counts of CD(4)(+) T lymphocyte and liver function including ALT, AST and TBil were tested.
  
  
  RESULTS
  During one-year HAART, HIV RNA of HIV-only group, HIV + HBV + HCV co-infection group and HIV + HCV co-infection group decreased significantly from (6.78 ± 1.08), (6.23 ± 1.34), (6.54 ± 1.23) lg copies/ml to (0.53 ± 0.15), (0.67 ± 0.16), (0.43 ± 0.11) lg copies/ml respectively (P < 0.001). And CD(4)(+) T lymphocyte counts of the three groups elevated significantly from (197 ± 127), (184 ± 113), (213 ± 143) cells/µl to (382 ± 74), (383 ± 70), (378 ± 76) cells/µl respectively (P < 0.001). However there were no differences among the three groups in HIV RNA and CD(4)(+) T lymphocyte counts. There were no differences in liver functions including ALT, AST and TBil among the three groups.
  
  
  CONCLUSIONS
  HIV co-infected with HBV and/or HCV does not impact on the efficacy of HAART. What more, HAART does not impact HCV replication.
authors.affiliation: Department of Pharmacology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Xiao-fei
authors.initials: XF
authors.lastname: Li
authors.forename: Quan-cheng
authors.initials: QC
authors.lastname: Kan
authors.forename: Yun
authors.initials: Y
authors.lastname: He
authors.forename: Zu-jiang
authors.initials: ZJ
authors.lastname: Yu
authors.forename: Zhi-qin
authors.initials: ZQ
authors.lastname: Li
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Liang
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D060085:Coinfection / Q000188:drug therapy* / Q000821:virology; D006678:HIV; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D016174:Hepacivirus; D006509:Hepatitis B / Q000188:drug therapy*; D006515:Hepatitis B virus; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D016896:Treatment Outcome