title: Carbapenem-resistant Pseudomonas aeruginosa: clonal spread in southern Brazil and in the state of Goiás.
abstract: This study evaluated the clonal spread of carbapenem-resistant P. aeruginosa producing SPM-1 type metallo-β-lactamase (MBL), at the university hospital of Florianópolis, Santa Catarina, Brazil, compared to an epidemic clone previously reported, as well as strains collected in other three Brazilian states. Among the isolates, 17 (62%) were clonal and highly related to strains from other regions of Brazil. Six clonal strains harbored the blaSPM-1 gene. The finding of a unique SPM-1 producer clone suggests that its dissemination has contributed to the high resistance to carbapenems in Brazilian hospitals.
authors.affiliation: Hospital Universitario, Universidade Federal de Santa Catarina, Brazil.
authors.forename: Mara Cristina
authors.initials: MC
authors.lastname: Scheffer
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Gales
authors.forename: Afonso Luis
authors.initials: AL
authors.lastname: Barth
authors.forename: José Rodrigues do
authors.initials: JR
authors.lastname: Carmo Filho
authors.forename: Libera Maria
authors.initials: LM
authors.lastname: Dalla-Costa
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001938:Brazil; D015780:Carbapenems / Q000494:pharmacology*; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; C476155:beta-lactamase SPM-1, Pseudomonas aeruginosa; D001618:beta-Lactamases