title: Halide-guided oligo(aryl-triazole-amide)s foldamers: receptors for multiple halide ions.
abstract: We synthesized and characterized a series of oligo(phenyl-amide-triazole)s that can fold into a helical conformation guided by halide ions. Their binding models and affinities are highly dependent on the length of the foldamer, media and the inducing capability of halide ions. The short foldamer with one helical turn shows a 1:1 binding stoichiometry to all halides, while the longer foldamer with two or three helical turns in principle can form 1:2 complexes with chloride anions even bromide anions with an enhancement on binding affinities. A result of quantitative NOE calculations imply that the longer foldamer should increase its helical pitch so as to release the electrostatic repulsion between halide ions.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xiang
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D001665:Binding Sites; D001965:Bromides / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D007477:Ions; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011108:Polymers / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D001965:Bromides; D002712:Chlorides; D007477:Ions; D011108:Polymers; D014230:Triazoles