title: A characterization of factors determining postoperative ileus after laparoscopic colectomy enables the generation of a novel predictive score.
abstract: OBJECTIVE
  Postoperative ileus (POI) after colorectal surgery is associated with prolonged hospital stay and increased costs. The aim of this study is to investigate pre-, intra-, and postoperative risk factors associated with the development of POI in patients undergoing laparoscopic partial colectomy.
  
  
  METHODS
  Patients operated between 2004 and 2008 were retrospectively identified from a prospectively maintained database, and clinical, metabolic, and pharmacologic data were obtained. Postoperative ileus was defined as the absence of bowel function for 5 or more days or the need for reinsertion of a nasogastric tube after starting oral diet in the absence of mechanical obstruction. Associations between likelihood of POI and study variables were assessed univariably by using χ tests, Fisher exact tests, and logistic regression models. A scoring system for prediction of POI was constructed by using a multivariable logistic regression model based on forward stepwise selection of preoperative factors.
  
  
  RESULTS
  A total of 413 patients (mean age, 58 years; 53.5% women) were included, and 42 (10.2%) of them developed POI. Preoperative albumin, postoperative deep-vein thrombosis, and electrolyte levels were associated with POI. Age, previous abdominal surgery, and chronic preoperative use of narcotics were independently correlated with POI on multivariate analysis, which allowed the creation of a predictive score. Patients with a score of 2 or higher had an 18.3% risk of POI (P < 0.001).
  
  
  CONCLUSIONS
  Postoperative ileus after laparoscopic partial colectomy is associated with specific preoperative and postoperative factors. The likelihood of POI can be predicted by using a preoperative scoring system. Addressing the postoperative factors may be expected to reduce the incidence of this common complication in high-risk patients.
authors.affiliation: Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, OH, USA.
authors.forename: Udo
authors.initials: U
authors.lastname: Kronberg
authors.forename: Ravi P
authors.initials: RP
authors.lastname: Kiran
authors.forename: Mohamed S M
authors.initials: MS
authors.lastname: Soliman
authors.forename: Jeff P
authors.initials: JP
authors.lastname: Hammel
authors.forename: Ursula
authors.initials: U
authors.lastname: Galway
authors.forename: John Calvin
authors.initials: JC
authors.lastname: Coffey
authors.forename: Victor W
authors.initials: VW
authors.lastname: Fazio
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003082:Colectomy / Q000009:adverse effects*; D003108:Colonic Diseases / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D045823:Ileus / Q000175:diagnosis / Q000209:etiology*; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors