title: No evidence for a low linear energy transfer adaptive response in irradiated RKO cells.
abstract: It has become increasingly evident from reports in the literature that there are many confounding factors capable of modulating radiation-induced non-targeted responses, such as the bystander effect and the adaptive response. In this paper, we examine recent data which suggest that the observation of non-targeted responses may not be universally observable for differing radiation qualities. We have conducted a study of the adaptive response following low-linear energy transfer exposures for human colon carcinoma cells and failed to observe adaption for the endpoints of clonogenic survival or micronucleus formation.
authors.affiliation: Cell Biology and Biochemistry, Pacific Northwest National Laboratory, PO BOX 999, MS J4-02, Richland, WA 99354, USA. marianne.sowa@pnl.gov
authors.forename: M B
authors.initials: MB
authors.lastname: Sowa
authors.forename: W
authors.initials: W
authors.lastname: Goetz
authors.forename: J E
authors.initials: JE
authors.lastname: Baulch
authors.forename: A J
authors.initials: AJ
authors.lastname: Lewis
authors.forename: W F
authors.initials: WF
authors.lastname: Morgan
mesh_terms: D000222:Adaptation, Physiological / Q000528:radiation effects*; D024201:Bystander Effect / Q000528:radiation effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects*; D003110:Colonic Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D018499:Linear Energy Transfer; D011829:Radiation Dosage