title: An expeditious route toward pyrazine-containing nucleoside analogues.
abstract: An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.
authors.affiliation: Department of Chemistry, Katholieke Universiteit Leuven, Belgium.
authors.forename: Sachin G
authors.initials: SG
authors.lastname: Modha
authors.forename: Jalpa C
authors.initials: JC
authors.lastname: Trivedi
authors.forename: Vaibhav P
authors.initials: VP
authors.lastname: Mehta
authors.forename: Denis S
authors.initials: DS
authors.lastname: Ermolat'ev
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken
mesh_terms: D001483:Base Sequence; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D009705:Nucleosides; D011719:Pyrazines; D014230:Triazoles