title: The clinical significance of 25OH-Vitamin D status in celiac disease.
abstract: Reduced bone mineral density is frequently found especially in adult celiac disease (CD) and dietary guidelines favor vitamin D supplementation in adults and children with CD. Vitamin D serum levels were investigated in CD populations in order to challenge its routine supplementation. Israeli (61), Spanish (59), CD children (groups 1 and 5, respectively) were compared to children with nonspecific abdominal pain (56), their parents (84) and Spanish adult CD patients (22) (group 2, 3, 4, respectively). 25(OH)-vitamin D was checked by LIAISON chemiluminescent immunoassays. Groups 5 and 1 had the highest levels compared to groups 4 and 3 with the lowest levels. The levels in groups 1 and 2 were comparable. Concerning 25(OH)-vitamin D sera levels, only the difference between group 5 and 4 was statistically significant (30.3 ± 12.3 and 20.2 ± 10.5 ng/ml, respectively p=0.003). When vitamin D was splitted above and below 20 ng/ml level, 54.5% of Spanish adult CD had vitamin D deficiency compared to 16.9% of the local CD children (p=0.001). 29.6% of group 2 had deficient levels compared to their parents with 50% (p=0.019). In conclusion, Vitamin D sera levels negatively correlate with age. Thus, mainly adult CD population should be assessed for vitamin D levels and supplemented accordingly.
authors.affiliation: Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. lerner_aaron@clalit.org.il
authors.forename: Aaron
authors.initials: A
authors.lastname: Lerner
authors.forename: Yinon
authors.initials: Y
authors.lastname: Shapira
authors.forename: Nancy
authors.initials: N
authors.lastname: Agmon-Levin
authors.forename: Avi
authors.initials: A
authors.lastname: Pacht
authors.forename: Dana
authors.initials: D
authors.lastname: Ben-Ami Shor
authors.forename: Hoyos Marcus
authors.initials: HM
authors.lastname: López
authors.forename: Maria
authors.initials: M
authors.lastname: Sanchez-Castanon
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000293:Adolescent; D000328:Adult; D002112:Calcifediol / Q000097:blood*; D002446:Celiac Disease / Q000097:blood* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged
chemical_list: D002112:Calcifediol