title: The effect of systematic structural modifications on the antibacterial activity of novel oxazolidinones.
abstract: A novel series of tetraethylene glycol (TEG) triazolyl and squaramide containing oxazolidinones were synthesized and tested for their antibacterial activity against a selected panel of Gram-positive and Gram-negative bacteria. The 4-TEG-triazolyl derivatives were prepared by 'click reaction'. The introduction of the TEG and squaramide groups did not favor antibacterial activity. The three nucleoside-containing oxazolidinones were also prepared by 'click' methodology resulted in weak antibacterial activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Medical and Health Science Center, University of Debrecen, H-4010 Debrecen, PO Box 70, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Pintér
authors.forename: Ilona
authors.initials: I
authors.lastname: Bereczki
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Roth
authors.forename: Attila
authors.initials: A
authors.lastname: Sipos
authors.forename: Reny
authors.initials: R
authors.lastname: Varghese
authors.forename: Edet Ekpenyong
authors.initials: EE
authors.lastname: Udo
authors.forename: Eszter
authors.initials: E
authors.lastname: Ostorházi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Rozgonyi
authors.forename: Oludotun Adebayo
authors.initials: OA
authors.lastname: Phillips
authors.forename: Pál
authors.initials: P
authors.lastname: Herczegh
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006018:Glycols / Q000138:chemical synthesis / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D006018:Glycols; D023303:Oxazolidinones; D014230:Triazoles