title: A PIM₂ analogue suppresses allergic airway disease.
abstract: Two approaches for the synthesis of a phosphatidylinositol dimannoside (PIM₂) analogue 4 that mimics the suppressive activity of natural PIMs and also synthetic PIM₂ have been developed. This analogue, where the inositol core was replaced by glycerol, was tested for its ability to suppress cellular inflammation in a mouse model of allergic asthma and shown to be effective in suppressing airway eosinophilia. Suppression of all inflammatory cells monitored was observed, indicating a general blockade of cellular activity. These data indicate that the inositol core is not essential for this suppressive activity.
authors.affiliation: The Malaghan Institute of Medical Research, Wellington, New Zealand.
authors.forename: Jacquie L
authors.initials: JL
authors.lastname: Harper
authors.forename: Colin M
authors.initials: CM
authors.lastname: Hayman
authors.forename: David S
authors.initials: DS
authors.lastname: Larsen
authors.forename: Gavin F
authors.initials: GF
authors.lastname: Painter
authors.forename: Gurmit
authors.initials: G
authors.lastname: Singh-Gill
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010716:Phosphatidylinositols / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D011657:Pulmonary Eosinophilia / Q000188:drug therapy
chemical_list: D018926:Anti-Allergic Agents; D010716:Phosphatidylinositols; C054977:phosphatidylinositol dimannoside; D010047:Ovalbumin