title: A retrospective study of the relation between vaccination and occurrence of seizures in Dravet syndrome.
abstract: Dravet syndrome is a severe epileptic encephalopathy starting in the first year of life. Mutations in SCN1A can be identified in the majority of patients, and epileptic seizures in the setting of fever are a clinical hallmark. Fever is also commonly seen after vaccinations and provocation of epileptic seizures by vaccinations in patients with Dravet syndrome has been reported, but not systematically assessed. In a retrospective evaluation of 70 patients with Dravet syndrome and SCN1A mutations, seizures following vaccinations were reported in 27%. In 58% of these patients vaccination-related seizures represented the first clinical manifestation. The majority of seizures occurred after DPT vaccinations and within 72 h after vaccination. Two-thirds of events occurred in the context of fever. Our findings highlight seizures after vaccinations as a common feature in Dravet syndrome and emphasize the need for preventive measures for seizures triggered by vaccination or fever in these children.
authors.affiliation: Department of Neuropediatrics, BHZ Vogtareuth, Epilepsy Center, Vogtareuth, Germany.
authors.forename: Blanca
authors.initials: B
authors.lastname: Tro-Baumann
authors.forename: Sarah
authors.initials: S
authors.lastname: von Spiczak
authors.forename: Jan
authors.initials: J
authors.lastname: Lotte
authors.forename: Thomas
authors.initials: T
authors.lastname: Bast
authors.forename: Edda
authors.initials: E
authors.lastname: Haberlandt
authors.forename: Robert
authors.initials: R
authors.lastname: Sassen
authors.forename: Alfred
authors.initials: A
authors.lastname: Freund
authors.forename: Steffen
authors.initials: S
authors.lastname: Leiz
authors.forename: Ulrich
authors.initials: U
authors.lastname: Stephani
authors.forename: Rainer
authors.initials: R
authors.lastname: Boor
authors.forename: Hans
authors.initials: H
authors.lastname: Holthausen
authors.forename: Ingo
authors.initials: I
authors.lastname: Helbig
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kluger
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects; D004831:Epilepsies, Myoclonic / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D015994:Incidence; D007223:Infant; D009154:Mutation / Q000235:genetics; D062550:NAV1.1 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins / Q000235:genetics; D012189:Retrospective Studies; D012640:Seizures / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D015222:Sodium Channels / Q000235:genetics; D013577:Syndrome; D014611:Vaccination / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D062550:NAV1.1 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins; C568242:SCN1A protein, human; D015222:Sodium Channels