title: Early prenatal morphine exposure impairs performance of learning tasks and attenuates in vitro heterosynaptic long-term potentiation of intermediate medial mesopallium in day-old chicks.
abstract: Based on our previous findings in day-old chicks with prenatal morphine-treated, embryonic days 5-8 is crucial for functional development of learning and memory, the underlying structure and cellular mechanisms were further explored. The prenatal morphine-exposed chicks showed deficits in passive avoidance learning and conditioned place preference, and attenuation in paired-pulse facilitation and heterosynaptic long-term potentiation in intermediate medial mesopallium (IMM) in vitro. These results suggest the altered synaptic plasticity of IMM by prenatal morphine exposure is involved in behavioral impairments.
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Jiang
authors.forename: Xingu
authors.initials: X
authors.lastname: He
authors.forename: Meng-Ya
authors.initials: MY
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Sui
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D003216:Conditioning, Operant / Q000187:drug effects; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D005917:Globus Pallidus / Q000502:physiology*; D007858:Learning / Q000187:drug effects*; D017774:Long-Term Potentiation / Q000187:drug effects*; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009294:Narcotics / Q000008:administration & dosage / Q000494:pharmacology*; D012201:Reward; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D009294:Narcotics; D009020:Morphine