title: Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: preliminary results.
abstract: Auditory sensory gating deficits have been reported in subjects with post-traumatic stress disorder (PTSD), but the hemispheric and neuronal origins of this deficit are not well understood. The objectives of this study were to: (1) investigate auditory sensory gating of the 50-ms response (M50) in patients diagnosed with PTSD by utilizing magnetoencephalography (MEG); (2) explore the relationship between M50 sensory gating and cortical thickness of the superior temporal gyrus (STG) measured with structural magnetic resonance imaging (MRI); and (3) examine the association between PTSD symptomatology and bilateral sensory gating. Seven participants with combat-related PTSD and eleven controls underwent the paired-click sensory gating paradigm. MEG localized M50 neuronal generators to the STG in both groups. The PTSD group displayed impaired M50 gating in the right hemisphere. Thinner right STG cortical thickness was associated with worse right sensory gating in the PTSD group. The right S1 M50 source strength and gating ratio were correlated with PTSD symptomatology. These findings suggest that the structural integrity of right hemisphere STG cortices play an important role in auditory sensory gating deficits in PTSD.
authors.affiliation: New Mexico VA Healthcare System Clinical Neuroscience Research Program, Albuquerque, NM, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Hunter
authors.forename: Gerardo
authors.initials: G
authors.lastname: Villarreal
authors.forename: Greg R
authors.initials: GR
authors.lastname: McHaffie
authors.forename: Billy
authors.initials: B
authors.lastname: Jimenez
authors.forename: Ashley K
authors.initials: AK
authors.lastname: Smith
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Calais
authors.forename: Faith
authors.initials: F
authors.lastname: Hanlon
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Thoma
authors.forename: José M
authors.initials: JM
authors.lastname: Cañive
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D001931:Brain Mapping; D004569:Electroencephalography; D004834:Epilepsy, Post-Traumatic / Q000473:pathology* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D055139:Sensory Gating / Q000502:physiology*; D013702:Temporal Lobe / Q000503:physiopathology*; D014728:Veterans; D047829:Vietnam Conflict