title: Centromeres: moving chromosomes through space and time.
abstract: Centromeres have played a pivotal role in the evolution of the eukaryote genome. Their indispensable involvement in chromosome segregation and the evolution of linkage groups throughout all eukaryotic lineages intuitively suggests conserved structure and function. Unexpectedly, recent molecular and biochemical analyses of centromeres have revealed highly divergent patterns in both DNA sequence and organization. Unlike the microtubules with which they interact, centromeres have undergone rapid diversification during evolution while retaining the same functional attributes. The most recent evidence indicates that centromeres may be species-specific entities composed of highly variable DNA families that interact with an array of non-histone proteins before attachment to the microtubules.
authors.affiliation: Research School of Biological Sciences, Australian National University, Canberra, A.C.T. 2601, Australia.
authors.forename: D D
authors.initials: DD
authors.lastname: Shaw