title: Obstetric outcome of women with in vitro fertilization pregnancies hospitalized for ovarian hyperstimulation syndrome: a case-control study.
abstract: OBJECTIVE
  To evaluate the obstetric outcome of women with IVF pregnancies hospitalized for ovarian hyperstimulation syndrome (OHSS).
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  Department of Obstetrics-Gynecology and Reproductive Medicine.
  
  
  METHODS
  All IVF patients hospitalized for OHSS with a positive pregnancy test matched to an IVF pregnancy control group who did not develop OHSS.
  
  
  METHODS
  Retrospective study of all clinical and laboratory data.
  
  
  METHODS
  OHSS morbidity, early pregnancy outcome, and obstetric complications.
  
  
  RESULTS
  The incidence of OHSS requiring hospitalization was 1.14% among 3,504 IVF cycles. Forty patients (31 singletons, 8 twins, and 1 triplet) hospitalized for severe OHSS with a mean duration of hospitalization of 10.2 ± 7.2 days were compared with a control group of 80 IVF pregnancies (48 singletons, 15 twins, and 2 triplets). Early OHSS occurred in 22.5% of patients, and late OHSS in the remaining 77.5% patients. In the OHSS group, 10% had thromboembolic complications. The miscarriage rate was similar for the OHSS group and the control IVF group (17.5% vs. 16%). Concerning ongoing clinical pregnancies, pregnancy-induced hypertension (PIH) and preterm labor were significantly higher in the OHSS group (respectively, 21.2% vs. 9.2% and 36% vs. 10.7%). In the subgroup of singletons, PIH was significantly higher for OHSS pregnancies than for controls.
  
  
  CONCLUSIONS
  Pregnancies after IVF and OHSS are associated with a greater risk of adverse obstetric outcome.
authors.affiliation: Department of Gynaecology and Obstetrics, Unit of Reproductive Medicine AP-HM La Conception, Marseille, France. blandine.courbiere@ap-hm.fr
authors.forename: Blandine
authors.initials: B
authors.lastname: Courbiere
authors.forename: Virginie
authors.initials: V
authors.lastname: Oborski
authors.forename: David
authors.initials: D
authors.lastname: Braunstein
authors.forename: Anne
authors.initials: A
authors.lastname: Desparoir
authors.forename: Agnès
authors.initials: A
authors.lastname: Noizet
authors.forename: Marc
authors.initials: M
authors.lastname: Gamerre
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000706:statistics & numerical data; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D055815:Young Adult