title: Rapid limit tests for metal impurities in pharmaceutical materials by X-ray fluorescence spectroscopy using wavelet transform filtering.
abstract: We introduce a new method for analysis of X-ray fluorescence (XRF) spectra based on continuous wavelet transform filters, and the method is applied to the determination of toxic metals in pharmaceutical materials using hand-held XRF spectrometers. The method uses the continuous wavelet transform to filter the signal and noise components of the spectrum. We present a limit test that compares the wavelet domain signal-to-noise ratios at the energies of the elements of interest to an empirically determined signal-to-noise decision threshold. The limit test is advantageous because it does not require the user to measure calibration samples prior to measurement, though system suitability tests are still recommended. The limit test was evaluated in a collaborative study that involved five different hand-held XRF spectrometers used by multiple analysts in six separate laboratories across the United States. In total, more than 1200 measurements were performed. The detection limits estimated for arsenic, lead, mercury, and chromium were 8, 14, 20, and 150 μg/g, respectively.
authors.affiliation: US Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri 63101, USA. sergey.arzhantsev@fda.hhs.gov
authors.forename: Sergey
authors.initials: S
authors.lastname: Arzhantsev
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: John F
authors.initials: JF
authors.lastname: Kauffman
mesh_terms: D019216:Metals, Heavy / Q000032:analysis*; D013052:Spectrometry, X-Ray Emission / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D019216:Metals, Heavy