title: Inhibitory effect of dexamethasone on arginine-vasopressin release induced by physical exercise in man.
abstract: To establish whether glucocorticoids inhibit the arginine-vasopressin (AVP) response to physical exercise, 10 healthy men underwent bicycle ergometer tests until exhaustion (exercise control test, exercise plus dexamethasone [2 or 4 mg in an intravenous bolus]). Physiological and biochemical variables were similar in all tests. Pretreatment with dexamethasone (2 or 4 mg) partially but significantly decreased the AVP response induced by physical exercise. Our results demonstrate a partial inhibition induced by glucocorticoids of AVP neurosecretion during cycle ergometer tests.
authors.affiliation: Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy. vittorio.coiro@unipr.it
authors.forename: Vittorio
authors.initials: V
authors.lastname: Coiro
authors.forename: Riccardo
authors.initials: R
authors.lastname: Volpi
authors.forename: Elio
authors.initials: E
authors.lastname: Volta
authors.forename: Andrea
authors.initials: A
authors.lastname: Melani
authors.forename: Maria Ludovica
authors.initials: ML
authors.lastname: Maffei
authors.forename: Paolo
authors.initials: P
authors.lastname: Chiodera
mesh_terms: D000328:Adult; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods*; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D001127:Arginine Vasopressin; D003907:Dexamethasone