title: Chronic treatment with imipramine and lithium increases cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats.
abstract: Adult hippocampal neurogenesis is reported to change in animal models of depression and antidepressants. We have used the mitotic marker 5-bromo-2'-deoxyyridine to address the effects of imipramine and lithium on cell proliferation and survival following chronic treatment with adrenocorticotropic hormone (ACTH) in the subgranular zone of the hippocampal dentate gyrus. ACTH treatment for 14 d decreased adult hippocampal cell proliferation and survival. Coadministration of imipramine and lithium for 14 d blocked the loss of cell proliferation but not cell survival resulting from the chronic treatment with ACTH. The coadministration of imipramine and lithium may have treatment-resistant antidepressive properties, which may be attributed, in part, to a normalization of hippocampal cell proliferation.
authors.affiliation: Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700–8530, Japan. ykita@pharm.okayama-u.ac.jp
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Maho
authors.initials: M
authors.lastname: Doi
authors.forename: Keiko
authors.initials: K
authors.lastname: Kuwatsuka
authors.forename: Yuka
authors.initials: Y
authors.lastname: Onoue
authors.forename: Ikuko
authors.initials: I
authors.lastname: Miyazaki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shinomiya
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Koyama
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sendo
authors.forename: Hiromu
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Masato
authors.initials: M
authors.lastname: Asanuma
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Gomita
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D018692:Antimanic Agents / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D006624:Hippocampus / Q000166:cytology*; D007099:Imipramine / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D055495:Neurogenesis / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000929:Antidepressive Agents, Tricyclic; D018692:Antimanic Agents; D000324:Adrenocorticotropic Hormone; D008094:Lithium; D007099:Imipramine