title: Adiposity, adipokines, and exhaled nitric oxide in healthy adults without asthma.
abstract: BACKGROUND
  Epidemiological studies have shown that obesity/adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity/adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity/adiposity in nonasthmatic healthy adults.
  
  
  METHODS
  We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity/adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses.
  
  
  RESULTS
  FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-α, or interleukin (IL)-6 was observed.
  
  
  CONCLUSIONS
  These findings suggest that in healthy subjects without asthma, obesity/adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Kim
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Kim
authors.forename: Ji Seon
authors.initials: JS
authors.lastname: Lee
authors.forename: Tai Yeon
authors.initials: TY
authors.lastname: Koo
authors.forename: Chang Beom
authors.initials: CB
authors.lastname: Lee
authors.forename: Ho Joo
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Shin
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Park
authors.forename: Jang Won
authors.initials: JW
authors.lastname: Sohn
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D001944:Breath Tests; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D012129:Respiratory Function Tests; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide