title: Clinico-pathological profile of acute promyelocytic leukaemia at Al-Amal Oncology-Haematology Centre, Qatar.
abstract: This cases series describes the profile of adult patients with acute promyelocytic leukaemia (APt) at a referral hospital in Qatar. Of 34 acute myeloid leukaemia (AML) cases diagnosed, 11(32%) were classified as APt. Disseminated intravascular coagulation was common at presentation (91%). Severe thrombocytopenia was seen in 73%, leukocytosis in 55% and severe anaemia in 45%. Only 2 patients were of the classic hypergranular type. In the remaining 9 patients, 3 morphological subtypes were recognized: microgranular variant (6 patients), hyperbasophilic (2 patients) and regular nuclear outline M3r (1 patient). Translocation t(15;17) was detected in 63% of cases. APL constitutes a high proportion of AML cases in Qatar, with considerable morphological heterogeneity and a oredominance of APL variants with unfavourable oresenting features.
authors.affiliation: Department of Laboratory Medicine and Pathology, A-Ameal Hospital, Qatar
authors.forename: F A
authors.initials: FA
authors.lastname: Ibrahim
authors.forename: M A
authors.initials: MA
authors.lastname: Yassin
authors.forename: H R
authors.initials: HR
authors.lastname: El-Ayoubi
authors.forename: I A
authors.initials: IA
authors.lastname: Alhiji
authors.forename: A S
authors.initials: AS
authors.lastname: Albinali
authors.forename: S M
authors.initials: SM
authors.lastname: Almansour
authors.forename: F M
authors.initials: FM
authors.lastname: Qafoud
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000453:epidemiology / Q000209:etiology; D001856:Bone Marrow Examination; D002173:Cancer Care Facilities; D020732:Cytogenetic Analysis; D005260:Female; D005434:Flow Cytometry; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000145:classification / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology*; D007964:Leukocytosis / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011780:Qatar / Q000453:epidemiology; D013921:Thrombocytopenia / Q000453:epidemiology / Q000209:etiology; D014178:Translocation, Genetic; D055815:Young Adult