title: Ghrelin and Ang 1-7 have cumulative vasodilatory effects on pulmonary vessels.
abstract: Ghrelin is an orexigenic hormone that has been shown to have vasodilator effects. Angiotensin 1-7 (Ang 1-7) is a bioactive component of the renin-angiotensin system and may play an important role in the regulation of cardiovascular homeostasis.
  
  
  OBJECTIVE
  The aim of this study was to investigate the interaction between ghrelin and a better known vasodilatator, Ang 1-7.
  
  
  METHODS
  The dose-dependent relaxing effects of ghrelin were assessed on pulmonary artery rings of male Wistar rats with intact endothelium in the absence or the presence of Ang 1-7. Ang 1-7 was added in the organ bath with 5 minutes before N(G)-nitro L-arginine methyl ester (L-NAME, 1 micro/M) and indomethacin administration in the presence of cumulative doses of ghrelin.
  
  
  RESULTS
  Our results showed that Ang 1-7 could improve and restore vasorelaxant effects of ghrelin on rat pulmonary rings with intact endothelium.
  
  
  CONCLUSIONS
  Vasodilatatory actions of ghrelin are potentiated by Ang 1-7 and mediated by local synthesis of prostaglandins and nitric oxide.
authors.affiliation: Functional Sciences Department, School of Medicine, Gr.T. Popa University of Medicine and Pharmacy Iaşi.
authors.forename: Maria
authors.initials: M
authors.lastname: Dincă
authors.forename: Irina Luciana
authors.initials: IL
authors.lastname: Dumitriu
authors.forename: Mihaela Beatrice
authors.initials: MB
authors.lastname: Gurzu
authors.forename: Simona Mihaela
authors.initials: SM
authors.lastname: Slătineanu
authors.forename: Liliana
authors.initials: L
authors.lastname: Foia
authors.forename: Luminita
authors.initials: L
authors.lastname: Vâţă
authors.forename: Elena
authors.initials: E
authors.lastname: Cojocaru
authors.forename: G
authors.initials: G
authors.lastname: Petrescu
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004730:Endothelium, Vascular / Q000187:drug effects; D054439:Ghrelin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D054439:Ghrelin; D010446:Peptide Fragments; D014665:Vasodilator Agents; D000803:Angiotensin I; C118790:angiotensin I (1-7)