title: Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of morinda elliptica.
abstract: 2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-?-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the roots of Morinda elliptica , were assayed for anti-HIV, cytotoxic and antimicrobial activites. Only damnacanthal showed moderate activity against HIV. It was cytotoxic towards the MCF-7 (breast carcinoma) and CEM-SS (T-lymphoblastic leukaemia) cell line. Nordamnacanthal was very cytotoxic against the CEM-SS cell lines. Other anthraquinones that showed strong cytotoxicity towards the cell lines tested were lucidin-?-methyl ether (CEM-SS and MCF-7) and rubiadin (CEM-SS). Three anthraquinones viz., nordamnacanthal, damnacanthal and morindone, were found to have strong antimicrobial activity.
authors.forename: A M
authors.initials: AM
authors.lastname: Ali
authors.forename: N H
authors.initials: NH
authors.lastname: Ismail
authors.forename: M M
authors.initials: MM
authors.lastname: Mackeen
authors.forename: L S
authors.initials: LS
authors.lastname: Yazan
authors.forename: S M
authors.initials: SM
authors.lastname: Mohamed
authors.forename: A S
authors.initials: AS
authors.lastname: Ho
authors.forename: N H
authors.initials: NH
authors.lastname: Lajis