title: Advanced left-atrial fibrosis is associated with unsuccessful maze operation for valvular atrial fibrillation.
abstract: OBJECTIVE
  Atrial dilatation and fibrosis are considered to be important factors in the occurrence and maintenance of atrial fibrillation (AF). However, the relationship between those structural remodeling and postoperative sinus conversions after a maze operation has been rarely studied. The purpose of this study was to determine whether pathological evaluation of atrial tissues was useful for predicting an unsuccessful maze operation in patients with valvular AF.
  
  
  METHODS
  Between March 2006 and June 2007, left-atrial tissues in the posterior wall and right-atrial appendage were obtained from 47 consecutive patients (24 patients with chronic AF, and 23 with sinus rhythm) undergoing mitral valve surgery (MVS). A concomitant maze operation was performed for all patients with chronic AF. Atrial cell diameters were measured using hematoxylin and eosin staining, and quantitative assessment of atrial fibrosis was performed with Masson trichrome staining using an image analyzer (Image Processor for Analytical Pathology, Sumika Technoservice Co., Hyogo, Japan).
  
  
  RESULTS
  Successful MVS was performed for all patients and there were no complications associated with tissue sampling. Patients with chronic AF had more advanced histological features in both atria as compared with those with sinus rhythm. Sixteen of 24 patients, who underwent a maze operation, had successfully restored sinus rhythm (successful maze group), while that in the remaining eight was not restored (unsuccessful maze group). Patients in the unsuccessful maze group had a larger left-atrial dimension and cardiothoracic ratio as compared with those in the successful group, whereas the duration of AF was not significantly different. Patients in the unsuccessful maze group also had greater hypertrophy of cardiomyocytes and more extensive intercellular fibrosis in the left atrium, while there were no differences for right-atrial pathological features between the groups. Multivariate logistic analysis confirmed that a larger amount of left-atrial fibrosis (>15%) was significantly associated with an unsuccessful maze operation.
  
  
  CONCLUSIONS
  The present results suggested that advanced fibrosis in the left atrium, but not in the right atrium, might be significantly associated with an unsuccessful maze operation in patients with valvular AF.
authors.affiliation: Department of Cardiovascular Surgery, Sakurabashi Watanabe Hospital, Osaka, Japan. s.kainuma@hotmail.co.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kainuma
authors.forename: Takafumi
authors.initials: T
authors.lastname: Masai
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshitatsu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Koji
authors.initials: K
authors.lastname: Takeda
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sawa
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D002908:Chronic Disease; D005260:Female; D005355:Fibrosis; D005500:Follow-Up Studies; D006325:Heart Atria / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000150:complications / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome; D014463:Ultrasonography