title: [Association of Rs10487667 genetic polymorphism of thromboxane synthase with myocardial infarction in Uigur population of Xinjiang].
abstract: OBJECTIVE
  To investigate the association between the polymorphism of thromboxane synthase gene (CYP5A1) and myocardial infarction (MI) of Uigur nationality patients in Xinjiang.
  
  
  METHODS
  Rs10487667 site polymorphism in CYP5A1 gene of 318 patients with MI (MI group) and 232 healthy control subjects (control group) were analyzed by polymerase chain reaction and restriction fragment length polymorphism. The serum thromboxane B(2)(TXB(2)) concentration was also detected in all subjects. The relationship of multiple factors and myocardial infarction was evaluated comprehensively by non-condition logistic regression analysis.
  
  
  RESULTS
  The frequencies of CYP5A1 gene Rs10487667 site polymorphism in MI group and control group were: GG type 0.204 (65/318) and 0.155 (36/232), GT type 0.553 (176/318) and 0.466 (106/232), TT type 0.242 (77/318) and 0.379 (88/232), respectively. There was significant difference in frequencies of GG genotype (χ(2) = 12.193, P = 0.002) between two groups and G allele frequency in MI group (0.481 (306/636)) was significant higher than control group (0.388 (180/464)) (χ(2) = 9.449, P = 0.021), but no difference in frequencies of GT and TT genotypes (χ(2) = 0.699, P > 0.05)between controls and MI cases. There was significant difference in serum TXB(2) level between MI ((184.3 ± 34.7) pg/ml) and control ((124.3 ± 28.1) pg/ml) groups (t = 5.503, P = 0.034). In the case and control group, the serum TXB(2) level of the person with GT + GG genotype ((164.21 ± 22.56) and (134.26 ± 19.83) pg/ml)) was significant higher than those of TT genotypes ((113.67 ± 54.23) and (98.54 ± 13.11) pg/ml) (t values were 5.433 and 5.108, respectively, both P values < 0.05). Logistic regression analysis showed that the T allele of the CYP5A1 gene was one independent risk factor of MI (OR = 1.673, 95%CI: 1.020 - 2.156) after adjustment of risk factors.
  
  
  CONCLUSIONS
  Rs10487667 polymorphism in CYP5A1 gene might be a risk factor of MI in Uigur population in Xinjiang, which maybe related with the significant high serum TXB(2) level.
authors.affiliation: Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: Bao-zhu
authors.initials: BZ
authors.lastname: Wang
authors.forename: Yi-tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Zhen-yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Xue-lian
authors.initials: XL
authors.lastname: Zhang
authors.forename: Bang-dang
authors.initials: BD
authors.lastname: Chen
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Zi-xiang
authors.initials: ZX
authors.lastname: Yu
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D013929:Thromboxane B2 / Q000097:blood; D013930:Thromboxane-A Synthase / Q000235:genetics*
chemical_list: D013929:Thromboxane B2; D013930:Thromboxane-A Synthase