title: [Daily medication of low-dose tadalafil improves endothelial function and erectile hardness of ED patients].
abstract: OBJECTIVE
  To evaluate the effects of daily medication of low-dose tadalafil on the improvement of endothelial function and erectile hardness in erectile dysfunction (ED) patients.
  
  
  METHODS
  A total of 60 ED patients and 24 controls were treated with oral tadalafil at 5 mg/d for 6 - 8 weeks, and evaluated by international index of erectile function-5 (IIEF-5), erectile hardness grading scale (EHGS) and brachial artery flow-mediated dilation (FMD) test before and after the treatment. All the data obtained were analyzed by independent-sample and paired-sample t tests, respectively.
  
  
  RESULTS
  The treatment and follow-up were accomplished in 51 of the ED cases. Compared with the controls, the ED patients showed significantly lower scores on IIEF-5 (23.6 +/- 1.0 vs 10.3 +/- 4.5, P < 0.01), EHGS (3.7 +/- 0.5 vs 2.0 +/- 0.6, P < 0.01) and FMD (14.1 +/- 2.1 vs 8.1 +/- 1, P < 0.01). Daily medication of tadalafil achieved an effectiveness rate of 96.1% (49/51) in the treatment of the ED patients, and significantly improved their scores on IIEF-5 (16.9 +/- 3.9 vs 10.6 +/- 4.5, P < 0.01), EHGS (2.6 +/- 0.7 vs 2.0 +/- 0.6, P < 0.01) and FMD (9.2 +/- 1.7 vs 8.1 +/- 0.9, P < 0.01), as compared with pretreatment.
  
  
  CONCLUSIONS
  Long-term daily medication of low-dose tadalafil can significantly improve endothelial function and erectile hardness of ED patients.
authors.affiliation: Department of Urology, The First Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong 510080, China. hyppin@163.com
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Huang
authors.forename: Fu-Fu
authors.initials: FF
authors.lastname: Zheng
authors.forename: Feng-Juan
authors.initials: FJ
authors.lastname: Yao
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Bian
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Ya-Dong
authors.initials: YD
authors.lastname: Zhang
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Ye
authors.forename: Xiang-Zhou
authors.initials: XZ
authors.lastname: Sun
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Deng
mesh_terms: D002243:Carbolines / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010410:Penile Erection; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000068581:Tadalafil; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil