title: Islet amyloid polypeptide gene variation (IAPP) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study.
abstract: BACKGROUND
  Islet amyloid polypeptide (IAPP) gene variation has recently been implicated in type 2 diabetes mellitus (T2D). However, to date, no prospective epidemiological data are available.
  
  
  METHODS
  The association between 10 IAPP tag-single nucleotide polymorphisms (tSNPs) and incident T2D was investigated in 22,715 Caucasian participants of the prospective Women's Genome Health Study. All were free of known cardiovascular disease, cancer, and diabetes at baseline. During a 13-year follow-up period, 1445 participants developed an incident T2D. Multivariable Cox regression analysis was performed to investigate the relationship between genotypes and T2D risk. Haplotype-based analysis was also performed.
  
  
  RESULTS
  No evidence for an association of any of the tSNPs tested or haplotypes thereof with T2D risk.
  
  
  CONCLUSIONS
  If corroborated in other large, prospective studies, the present findings further suggest that the IAPP gene locus may not be useful predictor for T2D risk assessment.
authors.affiliation: Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. rzee@rics.bwh.harvard.edu
authors.forename: Robert Y L
authors.initials: RY
authors.lastname: Zee
authors.forename: Patricia
authors.initials: P
authors.lastname: Pulido-Perez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Perez-Fuentes
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ridker
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Chasman
authors.forename: Jose R
authors.initials: JR
authors.lastname: Romero
mesh_terms: D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006262:Health; D006801:Humans; D058228:Islet Amyloid Polypeptide / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D044465:White People / Q000235:genetics
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D058228:Islet Amyloid Polypeptide; C517652:hemoglobin A1c protein, human