title: Calf thymus extract attenuates severity of experimental encephalomyelitis in Lewis rats.
abstract: The aim of this study was to evaluate the efficacy of treatment of Lewis rats with calf thymus extract (TFX®) and its six-peptide fraction on the course of experimental allergic encephalomyelitis (EAE). Interferon- ß served as a reference drug. We found that intramuscular administration of the thymus extract fraction significantly reduced clinical, immunological, histological, and ultrastructural alterations inherent in the disease. We suggest that TFX® or TFX®-derived fractions have potential as therapeutics in treatment of neurodegenerative diseases such as multiple sclerosis.
authors.affiliation: Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, Wrocław, Poland. zimecki@iitd.pan.wroc.pl
authors.forename: Michał
authors.initials: M
authors.lastname: Zimecki
authors.forename: Jolanta
authors.initials: J
authors.lastname: Artym
authors.forename: Maciej
authors.initials: M
authors.lastname: Kocięba
authors.forename: Jan
authors.initials: J
authors.lastname: Kuryszko
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kaleta-Kuratewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Marycz
mesh_terms: D000818:Animals; D002417:Cattle; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D005260:Female; D007150:Immunohistochemistry; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D013949:Thymus Extracts / Q000627:therapeutic use*
chemical_list: C019108:TFX; D013949:Thymus Extracts