title: [Hypertension and arteriosclerosis].
abstract: Hypertension is a known risk factor for arteriosclerosis, and causes both atherosclero= sis of medium-large arteries and arteriolosclerosis of the arterioles. Elevated blood pressure causes damage to the endothelium and vascular wall through both mechanical and humoral factors. We and others have shown that inhibition of the renin-angiotensin system at a 'critical period' during the development of hypertension results in a permanent suppression of hypertension in animal models. We have also reported that high-dose renin-angiotensin inhibition results in regression of hypertension, possibly by regression of renal arteriolar hypertrophy. These results suggest that understanding the process of arterial remodeling may play a key role in the development of new strategies for prevention and regression of hypertension and arteriosclerosis.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sasamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D001160:Arterioles / Q000473:pathology / Q000503:physiopathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D051381:Rats; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors