title: [Protective effect of GABA against hypoxic injury in rat hippocampal slices].
abstract: OBJECTIVE
  To study the mechanism of protective effect of GABA against hypoxic injury in rat hippocampal slices.
  
  
  METHODS
  The hippocampal slices from adult rats and extracellular recording technique were used to observe the effect of GABA on the evoked population spikes in rat hippocampal slices after hypoxia in vitro.
  
  
  RESULTS
  GABA can significantly delay the disappearance of PV, but have no effect on PS. When the receptor antagonist of GABA (bicuculline) and the inhibitor of Cl- channel (NPPB) were given, the protect effect could be suppressed.
  
  
  CONCLUSIONS
  GABA increases hypoxic tolerance of hippocampal slices. The mechanism of the effect of GABA may be involved in the elevation of chloride influx through GABA receptor.
authors.affiliation: Department of Neurobiology, Institute of basic Medical Sciences, Academy of Millitary Medical Sciences, Bejing 100850, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhao
authors.forename: Fu-Zhuang
authors.initials: FZ
authors.lastname: Wang
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Huang
authors.forename: Hang
authors.initials: H
authors.lastname: Yao
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Liu
authors.forename: Ming
authors.initials: M
authors.lastname: Fan
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000502:physiology; D005071:Evoked Potentials; D006624:Hippocampus / Q000503:physiopathology*; D000860:Hypoxia / Q000188:drug therapy / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D018118:Chloride Channels; D018696:Neuroprotective Agents; D005680:gamma-Aminobutyric Acid