title: From understanding synaptic plasticity to the development of cognitive enhancers.
abstract: Accumulating evidence reveals that synaptic dysfunction precedes neuronal loss in neurodegenerative diseases such as Alzheimer's disease. Intriguingly, synaptic abnormality is also implicated in a myriad of psychiatric disorders including depression. In particular, alterations in spine density and morphology have been associated with aberrant synaptic activity in these diseased brains. Understanding the molecular mechanisms underlying the regulation of spine morphogenesis, synaptic function and plasticity under physiological and pathological conditions will therefore provide critical insights for the development of potential therapeutic agents against these diseases. Here we summarize existing knowledge on some of the molecular players in synaptic plasticity, and highlight how these findings from basic neuroscientific research aid in the identification of novel drug leads for the development of therapeutics.
authors.affiliation: Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
authors.forename: Zelda H
authors.initials: ZH
authors.lastname: Cheung
authors.forename: Nancy Y
authors.initials: NY
authors.lastname: Ip
mesh_terms: D000818:Animals; D003704:Dementia / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D049229:Dendritic Spines / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D009473:Neuronal Plasticity / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D018697:Nootropic Agents