title: Anti-peroxidative and hypoglycaemic activity of salacia oblonga extract in diabetic rats.
abstract: Hypoglycaemic activity of a petroleum ether extract of the root bark of Salacia oblonga Wall. (Celastraceae) (SOB) was studied in streptozotocin (STZ) hyperglycaemic rats. In addition, the anti-lipid peroxidative activity of SOB was studied in hyperglycaemic rats. The extract showed significant hypoglycaemia ( p &lt; 0.001), which was supported by an insulin assay. A detailed biochemical study (thiobarbituric acid reactive substances, hydroperoxides, conjugated dienes, glutathione, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) in the renal tissue of diabetic animals treated with SOB demonstrated promising anti-lipid peroxidative activity. These results suggest that S. oblonga root bark possesses anti-diabetic and anti-peroxidative principles, and may be of value in the treatment of diabetes and associated renal complications.
authors.forename: K
authors.initials: K
authors.lastname: Krishnakumar
authors.forename: K T
authors.initials: KT
authors.lastname: Augusti
authors.forename: P L
authors.initials: PL
authors.lastname: Vijayammal