title: Mouse model for men with klinefelter syndrome: a multifaceted fit for a complex disorder.
abstract: 41XXY mouse models share many characteristics of the human 47XXY Klinefelter syndrome (KS). This manuscript discusses the relative role of androgen deficiency and X chromosome genes resulting in the XXY mouse phenotype. The similarities in phenotype between 47XXY men and 41XXY mice suggest that the clinical manifestations in XXY men may be because of gene-dosage effect from genes that escape X inactivation in mouse.
  
  
  CONCLUSIONS
  The 41XXY mouse is an excellent model for KS.
authors.affiliation: Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA. Swerdloff@labiomed.org
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Swerdloff
authors.forename: YanHe
authors.initials: Y
authors.lastname: Lue
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Liu
authors.forename: Krista
authors.initials: K
authors.lastname: Erkkilä
authors.forename: Christina
authors.initials: C
authors.lastname: Wang
mesh_terms: D000728:Androgens / Q000172:deficiency*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D018628:Gene Dosage / Q000235:genetics; D006801:Humans; D007713:Klinefelter Syndrome / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D049951:X Chromosome Inactivation
chemical_list: D000728:Androgens