title: [Study on the efficacy and safety of ultrasound ablation in treatment of uterine fibroids].
abstract: OBJECTIVE
  To investigate the safety and efficacy of ultrasound ablation in treatment of uterine fibroids.
  
  
  METHODS
  Ninety-nine patients with 117 leiomyomas in total treated by Haifu JC focused ultrasound tumor therapeutic system were enrolled in prospective and non-randomized clinical trial in First Affiliated Hospital of Chongqing Medical University and Academy of Military Medical Sciences. Ultrasound ablation was performed guided by real-time ultrasonography under conscious sedation for single session. All patients were followed up at 6 months after treatment. On the day of treatment and after 1 month, patients were given by magnetic resonance imaging (MRI) exam to evaluate the effect of fibroids ablation. At 3 and 6 months after treatment, the ratio of ablated area and volume reduction of fibroids more than 50% were evaluated by MRI exam again. The symptoms improvements were evaluated by uterine fibroid symptom (UFS) and complications were analyzed by guideline of society of international radiation (SIR).
  
  
  RESULTS
  The average ablated area ratio of the target fibroid was (76 ± 24)%. The average reduction in fibroid volume determined by MRI at 3 and 6 months after treatment was (45 ± 21)% and (59 ± 26)%. Which were significantly decreased than those before treatment (P < 0.05). At 6 months after treatment, 84.6% (99/117) of patients showed more than 50% volume reduction, the rate of improved symptom score was 92% (66/72). All patients could resume normal daily activities at 2 hours after treatment. The adverse reactions of SIR C-D included delayed hospitalization, repeat treatment and increased level of nursing. E-F included permanent sequelae and death. In this study, no adverse reactions of C-F were recorded. Common complications (SIR A-B, only observation or simple management without sequelae) were 35% (35/99). Four cases with adverse reactions B of SIR were found, including 2 cases with skin burning of degree II and 2 cases with febrile, they were administered by symptomatic therapy and changing dressing. The other adverse reaction A of SIR included sorness of buttock, vaginal discharge, dysuria and painful urination, they were only suggested by follow-up.
  
  
  CONCLUSIONS
  It was efficacy and safe that ultrasound ablation as a single strategy were used in treatment of uterine fibroids.
authors.affiliation: Department of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Wen-Zhi
authors.initials: WZ
authors.lastname: Chen
authors.forename: Liang-Dan
authors.initials: LD
authors.lastname: Tang
authors.forename: Wu-Wei
authors.initials: WW
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Wen-Xiu
authors.initials: WX
authors.lastname: Xia
authors.forename: Jie-Min
authors.initials: JM
authors.lastname: Zhou
authors.forename: Bao-Rang
authors.initials: BR
authors.lastname: Zhu
authors.forename: Chun-Quan
authors.initials: CQ
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Linghu
authors.forename: Jin-Yun
authors.initials: JY
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Yong-Bin
authors.initials: YB
authors.lastname: Deng
authors.forename: Zhi-Biao
authors.initials: ZB
authors.lastname: Wang
mesh_terms: D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D007889:Leiomyoma; D011446:Prospective Studies; D016896:Treatment Outcome; D014594:Uterine Neoplasms