title: Prevalence and long-term glucose metabolism evolution of post-transplant diabetes mellitus in Chinese renal recipients.
abstract: OBJECTIVE
  To assess the prevalence and predictors of post-transplant diabetes mellitus (PTDM) in Chinese renal recipients and describe their long-term evolution of glucose metabolism.
  
  
  METHODS
  887 non-diabetic Chinese adult renal recipients were studied retrospectively, with a median follow-up of 7 years. PTDM patients were categorized into transient PTDM and permanent PTDM. The cumulative incidence and risk factors of PTDM were estimated by Kaplan-Meier and Cox regression.
  
  
  RESULTS
  The cumulative incidence of PTDM at 3 months, 1, 3, 5, 10, 15 and 20 years post-transplant was 10.4%, 11.4%, 13.4%, 15.2%, 22.7%, 27.9% and 38.3%, respectively. 61.9% of PTDM cases were diagnosed within the first three months and 61.6% of them developed persistent diabetes in the future. Risk factors for all PTDM included older age, body mass index (BMI)≥25 kg/m(2), triglycerides≥1.5 mmol/L, rejection, the use of tacrolimus and diltiazem. The predictors of permanent PTDM included age >50 years (RR=2.322, 95% CI 1.255-4.296, P=0.007), BMI≥25 kg/m(2) (RR=1.699, 95% CI 1.014-2.846, P=0.044) and the use of tacrolimus (RR=1.835, 95% CI 1.181-2.851, P=0.007).
  
  
  CONCLUSIONS
  Patients were most susceptible to PTDM within the first three months post-transplant and more than half of them developed persistent diabetes in the future. Age >50 years, overweight and tacrolimus application were risk factors for both PTDM and permanent PTDM.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xu
authors.forename: Jia-xian
authors.initials: JX
authors.lastname: Liang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Yao
authors.forename: Sunil
authors.initials: S
authors.lastname: Pokharel
authors.forename: Guo-dong
authors.initials: GD
authors.lastname: Chen
authors.forename: Chang-xi
authors.initials: CX
authors.lastname: Wang
authors.forename: Yan-bing
authors.initials: YB
authors.lastname: Li
authors.forename: Hai-peng
authors.initials: HP
authors.lastname: Xiao
mesh_terms: D000328:Adult; D044466:Asian People; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007166:Immunosuppressive Agents; D005947:Glucose