title: [Gene-gene interaction between DNMT3B and DRD1 in schizophrenia].
abstract: OBJECTIVE
  to identify the impact of gene-gene interaction between DNMT3B and DRD1 on the risk of schizophrenia.
  
  
  METHODS
  two SNPs (rs2424908 and rs6119954) within DNMT3B and five SNPs (rs4532, rs5326, rs2168631, rs6882300 and rs267418) within DRD1 were genotyped in 365 schizophrenic patients and 365 healthy controls. The gene-gene interaction between DNMT3B and DRD1 was analyzed by Multifactor Dimensionality Reduction (MDR) software.
  
  
  RESULTS
  the frequency of genotypes of rs6119954 within DNMT3B was significantly higher in patients than that in controls (χ(2) = 8.06, P = 0.018). MDR revealed that the significance were shown in patterns with 2 SNPs (rs6119954-rs267418) (OR = 1.79, 95%CI: 1.29 - 2.47; χ(2) = 12.51, P = 0.0004), 3 SNPs (rs6119954-rs5326-rs267418) (OR = 2.36, 95%CI: 1.73 - 3.22; χ(2) = 29.33, P < 0.0001) and 4 SNPs (rs2424908-rs6119954-rs5326-rs267418) (OR = 3.08, 95%CI: 2.24 - 4.24;χ(2) = 48.88, P < 0.0001).
  
  
  CONCLUSIONS
  the gene-gene interaction between DNMT3B and DRD1 may exist and increase the risk for schizophrenia.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Xie
authors.forename: Ya-Song
authors.initials: YS
authors.lastname: DU
authors.forename: Juan
authors.initials: J
authors.lastname: Fan
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Shun-Ying
authors.initials: SY
authors.lastname: Yu
authors.forename: Yi-Ru
authors.initials: YR
authors.lastname: Fang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult; D000097584:DNA Methyltransferase 3B
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases; D017447:Receptors, Dopamine D1; D000097584:DNA Methyltransferase 3B