title: 4-Deacetylbaccatin III: a proposed biosynthetic precursor of paclitaxel from the bark of Taxus wallichiana.
abstract: 4-Deacetylbaccatin III was isolated and characterized from the bark of Taxus wallichiana Zucc. It was previously identified as an intermediate during the synthesis of paclitaxel and was proposed as a precursor for the biosynthesis of paclitaxel. Existence of 4-deacetylbaccatin III in T. wallichiana is strong evidence for the previously proposed biosynthetic pathway of paclitaxel via 4-deacetylbaccatin III.
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, NWFP, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nisar
authors.forename: Mughal
authors.initials: M
authors.lastname: Qayum
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.forename: Inamullah
authors.initials: I
authors.lastname: Khan
authors.forename: Waqar Ahamad
authors.initials: WA
authors.lastname: Kaleem
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D015394:Molecular Structure; D017239:Paclitaxel / Q000096:biosynthesis* / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D043823:Taxoids / Q000737:chemistry* / Q000378:metabolism*; D020946:Taxus / Q000737:chemistry* / Q000378:metabolism
chemical_list: C555562:4-deacetylbaccatin III; D043823:Taxoids; D017239:Paclitaxel