title: [The potential role of heat shock proteins in the treatment of ovarian cancer].
abstract: Ovarian carcinoma has the highest mortality among gynecologic cancers. Most of the patients are sensitive to the first-line platinum-based combined chemotherapy and they will present a complete response, but most of them will relapse within 24 months. The resistance to chemotherapy is a great therapeutic challenge. Recent figures show that heat shock proteins play a significant role in certain mechanisms of carcinogenesis and are involved in the resistance to anticancer drug therapy. Our paper gives a summary of recent data concerning heat shock proteins in ovarian carcinoma.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Szülészeti és Nőgyógyászati Klinika Budapest Üllői út 78/A 1082. langmarzoltan@hotmail.com
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Langmár
authors.forename: Gábor
authors.initials: G
authors.lastname: Vleskó
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018835:Chaperonin 10 / Q000378:metabolism; D018834:Chaperonin 60 / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000628:therapy*; D017671:Platinum Compounds / Q000008:administration & dosage
chemical_list: D018835:Chaperonin 10; D018834:Chaperonin 60; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D017671:Platinum Compounds