title: [Usefulness of low-dose and long-term administration of imatinib in patients with liver metastases of rectal GIST and GIST of stomach].
abstract: Imatinib is an effective drug for KIT positive GIST, and the usual dose is 400 mg/day. On the other hand, imatinib sometimes causes leucopenia and it is hard to maintain a dosage of 400 mg/day. We reported here the two cases with a remarkable response of unresectable GIST using a low-dose and long-term administration of imatinib. It seems that a low dose and long-term administration of imatinib will be an important therapy for unresectable GIST.
authors.affiliation: Dept. of Surgery, National Hospital Organization Yonago Medical Center.
authors.forename: Osamu
authors.initials: O
authors.lastname: Kimura
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamamoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hisamitsu
authors.forename: Nariyuki
authors.initials: N
authors.lastname: Yamane
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hamazoe
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage*; D011743:Pyrimidines / Q000008:administration & dosage*; D012004:Rectal Neoplasms / Q000473:pathology*; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate