title: [Major depressive disorder: factors of risk, vulnerability and protection].
abstract: Major depressive disorder is a disease whose course is often chronic because the prevalence of recurrence is high. Therefore, it is important to know the risk factors of relapse (number of previous episodes, persistence of residual depressive symptoms…). Moreover, identifying factors of vulnerability of the disease may help to detect very-high-risk subjects in order to prevent the disease onset. Many hypothesis are explored: serotonin dysfunction, axis of stress, alteration of brain structures. Finally, antidepressant treatment is a protective factor and is efficient to limit the risk of chronicity.
authors.affiliation: Université Montpellier, Département Hospitalo-Universitaire d'Urgences et Post-Urgences Psychiatriques, INSERM U888, CHRU Montpellier, France.
authors.forename: E
authors.initials: E
authors.lastname: Olié
authors.forename: P
authors.initials: P
authors.lastname: Courtet
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D008016:Life Change Events; D008134:Long-Term Care; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology; D012307:Risk Factors; D055502:Secondary Prevention; D012701:Serotonin / Q000502:physiology; D012931:Social Environment
chemical_list: D000928:Antidepressive Agents; D012701:Serotonin; D006854:Hydrocortisone