title: The relation between Lp-PLA2 levels with periodic limb movements.
abstract: OBJECTIVE
  Lipoprotein-associated phospholipase A2 (Lp-PLA2), a novel marker of vulnerable plaque to prone rupture, is a predictor of both cardiovascular event and cerebrovascular event, and highly sensitive-C-reactive protein (hs-CRP) is an acute-phase response protein implicated in a broad range of cardiovascular diseases. We aimed to examine the association between periodic limb movements in sleep (PLMs) with circulating Lp-PLA2 and hs-CRP levels in patients with PLMs.
  
  
  METHODS
  Seventy patients with newly diagnosed PLM with polysomnography were enrolled this study. Patients were divided into two groups according to PLM index (normal PLM index, <15; elevated PLM index, ≥15). Lp-PLA2 and hs-CRP concentrations were measured in serum samples by turbidimetric and nephelometric methods, respectively. The concentrations of these parameters were compared between two groups and correlation analysis was performed between PLMs and Lp-PLA2 and hs-CRP levels.
  
  
  RESULTS
  Lp-PLA2 levels and hs-CRP were significantly increased in elevated PLM index group compared with the control group (206.8 ± 78.1 vs 157.8 ± 56.7, p = 0.003, and 4.2 ± 3.5 vs 2.4 ± 2.1, p = 0.02, respectively). PLM index was positively correlated with Lp-PLA2 levels (r = 0.40, p = 0.001) and hs-CRP (r = 0.24, p = 0.05). In the linear regression model, Lp-PLA2 was an independent predictor of PLM index (R(2) = 0.36, p = 0.005).
  
  
  CONCLUSIONS
  This study demonstrated an independent linear relation between PLM index and Lp-PLA2. In addition, it was seen increased Lp-PLA2 and hs-CRP levels in patients with elevated PLM index. Based on these results, we can suggest that risk of vascular events may be increased in patients with PLMs and with increased PLM index.
authors.affiliation: Department of Pulmonary Medicine, Konya Education and Research Hospital, Meram, Konya, Turkey. tahabekci@yahoo.com
authors.forename: Taha Tahir
authors.initials: TT
authors.lastname: Bekci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kayrak
authors.forename: Aysel
authors.initials: A
authors.lastname: Kiyici
authors.forename: Hatem
authors.initials: H
authors.lastname: Ari
authors.forename: Turgut
authors.initials: T
authors.lastname: Teke
authors.forename: Emin
authors.initials: E
authors.lastname: Maden
authors.forename: Hakan
authors.initials: H
authors.lastname: Akilli
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D001143:Arousal / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000201:enzymology; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020189:Nocturnal Myoclonus Syndrome / Q000175:diagnosis / Q000201:enzymology*; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D011446:Prospective Studies; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000201:enzymology; D013223:Statistics as Topic; D014421:Turkey
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D010100:Oxygen