title: Chromosome 17 in FTLD: from MAPT tau to progranulin and back.
abstract: Frontotemporal Lobar degeneration (FTLD) is one of the most important neurodegenerative conditions, affecting in the presenium, but more recently recognized also in aged population. The strong genetic background, along with autopsy determinations prompted the identification of the two major genes associated to the disease: MAPT gene, and Progranulin (PGRN) gene. In this review, we highlighted the milestones of these discoveries, and their implication for the development of future therapeuthical approaches.
authors.affiliation: Clinic of Neurology, Spedali Civili, University of Brescia, P.zzale Spedali Civili, Brescia, Italy. antoalberici@yahoo.it
authors.forename: A
authors.initials: A
authors.lastname: Alberici
authors.forename: M
authors.initials: M
authors.lastname: Cosseddu
authors.forename: A
authors.initials: A
authors.lastname: Padovani
authors.forename: B
authors.initials: B
authors.lastname: Borroni
mesh_terms: D000818:Animals; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D057180:Frontotemporal Dementia / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D000077153:Progranulins; D016875:tau Proteins / Q000235:genetics*
chemical_list: C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; C054369:MAPT protein, human; D000077153:Progranulins; D016875:tau Proteins