title: The role of the CCR2 gene polymorphism in abdominal aortic aneurysms.
abstract: OBJECTIVE
  Chronic inflammation play an important role on abdominal aortic aneurysms (AAA) formation. Chemokine receptor-2 (CCR2) is involved in regulation of the inflammatory response. However, relation between CCR2 polymorphism and AAA formation in human has not yet been investigated. In this study, we aimed to investigate the relationship between AAA and CCR2-V64I gene polymorphism.
  
  
  METHODS
  In this study, 100 consecutive patients with AAA and 138 individuals with normal aortic diameter were included. CCR2-V64I gene polymorphism were analyzed by PCR-RFLP technique. Genotype distribution and allele frequencies of CCR2-V64I gene polymorphism in patients with AAA and healthy subjects were compared.
  
  
  RESULTS
  CCR2 heterozygote V64I polymorphism and allele frequency were more frequently observed in the AAA group (p = 0.01, p = 0.004). Significant relationship was observed between CCR2 V64I polymorphism (OR:2.31, 95% CI:1.19-4.46, p = 0.01) and presence of AAA in multivariate regression analysis.
  
  
  CONCLUSIONS
  The present study, showed us a relationship between CCR2-V64I polymorphism and AAA.
authors.affiliation: Department of Cardiovascular Surgery, Cumhuriyet University School of Medicine, Sivas, Turkey. nurkay@gmail.com
authors.forename: Nurkay
authors.initials: N
authors.lastname: Katrancioglu
authors.forename: Sinasi
authors.initials: S
authors.lastname: Manduz
authors.forename: Oguz
authors.initials: O
authors.lastname: Karahan
authors.forename: Mehmet Birhan
authors.initials: MB
authors.lastname: Yilmaz
authors.forename: Ilhan
authors.initials: I
authors.lastname: Sezgin
authors.forename: Gokhan
authors.initials: G
authors.lastname: Bagci
authors.forename: Ocal
authors.initials: O
authors.lastname: Berkan
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D054390:Receptors, CCR2 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C515334:CCR2 protein, human; D054390:Receptors, CCR2