title: Inorganic coatings for cardiovascular stents: In vitro and in vivo studies.
abstract: The in-vitro and in-vivo biocompatibility of two oxides (TiO and ZrO) and diamond-like carbon (D) coated stents has been assessed and compared with uncoated stainless steel (St) stents. In vitro studies demonstrated that both fibrinogen adsorption and platelet adhesion were significantly higher on D coating compared to those on oxide coatings and uncoated stainless steel. In addition TiO and ZrO coatings showed evidence of a minor inflammatory response and more complete endothelialization of the aorta than that seen around D coated and uncoated St stents. The resulting neointimal growth in the aorta with TiO, ZrO, and D coated and uncoated St stents, measured 8 weeks after stenting (the ratio of the neointima in the stented artery to the non-stented artery) was 1.03 + 0.28, 0.85 + 0.36, 1.78 + 1.26, and 1.15 + 0.56, accordingly. From the data obtained it could be concluded that the increased neointima measured around D-coated stents, may be due to both, the inferior haemocompatibility of the diamond-like carbon coating and mechanical instability of D coating observed in an in vivo environment.
authors.affiliation: School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ, UK. l.mikhalovska@bton.ac.uk
authors.forename: Lyuba
authors.initials: L
authors.lastname: Mikhalovska
authors.forename: Nataliya
authors.initials: N
authors.lastname: Chorna
authors.forename: Oleg
authors.initials: O
authors.lastname: Lazarenko
authors.forename: Peter
authors.initials: P
authors.lastname: Haworth
authors.forename: Arnaud
authors.initials: A
authors.lastname: Sudre
authors.forename: Sergey
authors.initials: S
authors.lastname: Mikhalovsky
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology; D002244:Carbon; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects*; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D058426:Neointima; D010973:Platelet Adhesiveness / Q000187:drug effects*; D013193:Stainless Steel; D015607:Stents / Q000592:standards*; D014025:Titanium; D015040:Zirconium
chemical_list: D020099:Coated Materials, Biocompatible; D013193:Stainless Steel; C009495:titanium dioxide; D002244:Carbon; D005340:Fibrinogen; D015040:Zirconium; D014025:Titanium; C028541:zirconium oxide