title: Two case-reports of the limb salvage treatment of osteosarcoma consolidated with obvious pathological fractures.
abstract: OBJECTIVE
  The effect of the limb salvage of the treatment of Osteosarcoma Consolidated with Obvious Pathological Fractures is not very well, the purpose of this paper is to track the efficacy of limb salvage treatment when the patients accepted the artery intervention chemotherapy and enclosed 2 clinical case-reports.
  
  
  METHODS
  From January 2003 to September 2005, 2 clinical cases which one is a male, 29 years old, was confirmed osteosarcoma on the left distal femur, and the other is a female, 15 years old and has osteosarcoma on the right arm with obvious pathological fracture. After receiving arterial chemotherapy pump embedded, then started chemotherapy after the tumor biopsy, and the next process prosthesis replacement in limb salvage surgery after 5 times chemotherapy, follow on the next 5 times chemotherapy after the surgery.
  
  
  RESULTS
  With an average follow-up 70 months, there are no postoperative infection and prosthesis loosening found, also didn't detected tumor recurrence and metastasis, and the limb function recovered well.
  
  
  CONCLUSIONS
  With the effective, neoadjuvant chemotherapy and comprehensive treatment, salvage treatment is not the contraindication of the patients with pathological fractures of combined primary osteosarcoma, and the treatment with long-term follow-up effectively.
authors.affiliation: Department of Bone Tumor, Academy of Military Medical Sciences, No.8 of East Avenue, Fengtai District, Beijing 100071, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Cui
authors.forename: D F
authors.initials: DF
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.forename: S B
authors.initials: SB
authors.lastname: Liu
authors.forename: Y S
authors.initials: YS
authors.lastname: Liu
authors.forename: J M
authors.initials: JM
authors.lastname: Zhai
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*