title: Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling.
abstract: A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1-4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Room 18-490, Cambridge, Massachusetts 02139, USA.
authors.forename: Todd D
authors.initials: TD
authors.lastname: Senecal
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Parsons
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D058451:Oxidative Coupling; D013696:Temperature
chemical_list: D001897:Boronic Acids; D006845:Hydrocarbons, Fluorinated; D003300:Copper