title: Primary plasma cell leukemia with light chain secretion and multiple chromosomal abnormalities: How successfully treated? - A case report with review of literature.
abstract: Primary plasma cell leukemia is a rare form of plasma cell dyscrasia. We present a case which had leukocytosis with numerous circulating plasma cells in the peripheral blood. Flow cytometry revealed an unusual CD117 expression. Free light chain analysis in the serum showed a markedly elevated level of free lambda light chains. Radiography did not reveal any lytic lesions. Fluorescent in-situ hybridization analysis revealed deletion of 13q14.3 and t(4;14)/t(11;14), while the cytogenetic analysis was normal. The patient was given chemotherapy and was subjected to autologous stem cell transplant, after which she is in complete remission till date.
authors.affiliation: Department of Laboratory Medicine, Indo-American Cancer Institute and Research Centre, Hyderabad, India.
authors.forename: Manu
authors.initials: M
authors.lastname: Goyal
authors.forename: Noorjahan
authors.initials: N
authors.lastname: Mohammad
authors.forename: Satya Dattatreya
authors.initials: SD
authors.lastname: Palanki
authors.forename: Salil N
authors.initials: SN
authors.lastname: Vaniawala