title: [A long-term survival case of unresectable intrahepatic cholangiocarcinoma treated with chemotherapy].
abstract: An 83-year-old man commuting to our hospital with postoperative ascending colon cancer was pointed out an increase of CA19-9. CT scan revealed an intrahepatic cholangiocarcinoma in the left lobe. In May 2007, an operation was performed. We recognized a lymph node swelling in the hepatoduodenal ligament. Pathologically, it was moderately differentiated adenocarcinoma. Therefore, the operation did only the cholecystectomy. Gemcitabine was administered once a week for 3 weeks followed by a week rest. It was administered for about 20 months and the evaluation during the period was PR or SD. Afterwards, the tumor had increased gradually. Gemcitabine was changed to S-1. Then, S-1 was changed to gemcitabine again because the enlargement of the tumor and the rise of tumor markers were observed. Consequently, tumor markers decreased. Now, the patient is under an outpatient care maintaining ADL.
authors.affiliation: Dept. of Surgery, Ono Memorial Hospital.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Tamura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Mizuyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Shinto
authors.forename: Tamahiro
authors.initials: T
authors.lastname: Nishihara
authors.forename: Hiroji
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Yoshioki
authors.initials: Y
authors.lastname: Ono
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000188:drug therapy*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000188:drug therapy*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine