title: Airway epithelium mediates the anti-inflammatory effects of exercise on asthma.
abstract: Airway epithelium plays an important role in the asthma physiopathology. Aerobic exercise decreases Th2 response in murine models of allergic asthma, but its effects on the structure and activation of airway epithelium in asthma are unknown. BALB/c mice were divided into control, aerobic exercise, ovalbumin-sensitized and ovalbumin-sensitized plus aerobic exercise groups. Ovalbumin sensitization occurred on days 0, 14, 28, 42, and aerosol challenge from day 21 to day 50. Aerobic exercise started on day 22 and ended on day 50. Total cells and eosinophils were reduced in ovalbumin-sensitized group submitted to aerobic exercise. Aerobic exercise also reduced the oxidative and nitrosative stress and the epithelial expression of Th2 cytokines, chemokines, adhesion molecules, growth factors and NF-kB and P2X7 receptor. Additionally, aerobic exercise increased the epithelial expression of IL-10 in non-sensitized and sensitized animals. These findings contribute to the understanding of the beneficial effects of aerobic exercise for chronic allergic airway inflammation, suggesting an immune-regulatory role of exercise on airway epithelium.
authors.affiliation: Department of Physical Therapy (LIM 34), University of São Paulo, School of Medicine, Avenida Doutor Arnaldo 455, São Paulo, Brazil. rodrelena@yahoo.com.br
authors.forename: Rodolfo Paula
authors.initials: RP
authors.lastname: Vieira
authors.forename: Alessandra Choqueta de
authors.initials: AC
authors.lastname: Toledo
authors.forename: Sérgio César
authors.initials: SC
authors.lastname: Ferreira
authors.forename: Angela Batista Gomes dos
authors.initials: AB
authors.lastname: Santos
authors.forename: Maria Cristina Rodrigues
authors.initials: MC
authors.lastname: Medeiros
authors.forename: Márcia
authors.initials: M
authors.lastname: Hage
authors.forename: Thaís
authors.initials: T
authors.lastname: Mauad
authors.forename: Milton de Arruda
authors.initials: Mde A
authors.lastname: Martins
authors.forename: Marisa
authors.initials: M
authors.lastname: Dolhnikoff
authors.forename: Celso Ricardo Fernandes de
authors.initials: CR
authors.lastname: Carvalho
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D018893:Bronchoalveolar Lavage; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010805:Physical Conditioning, Animal; D011014:Pneumonia / Q000276:immunology* / Q000473:pathology; D020545:Respiratory Mucosa / Q000276:immunology* / Q000473:pathology
chemical_list: D000485:Allergens; D010047:Ovalbumin