title: Compounds from Kadsura angustifolia with anti-HIV activity.
abstract: Four new cycloartane triterpenoids, angustific acid A (1), angustific acid B (2), angustifodilactone A (3) and angustifodilactone B (4) were isolated from the branches of Kadsura angustifolia together with six known compounds, micranoic acid B (5), nigranoic acid (6), schisandrin (7), schisantherin D (8), interiotherin B (9), schisantherin B (10). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. Compound 1, characterized by the presence of a C-16/C-17, C-20/C-21 conjugated diene and a C-1/C-7 ester bridge formed in rings A and B, provided a novel structural skeleton for 3,4-secocycloartane triterpenoid derivatives. In addition, the anti-HIV activities of these compounds were determined in infected C8166 cells, and it was found that angustific acid A (1) exhibited the most potent anti-HIV activity with an EC(50) value of 6.1 μg/mL and a therapeutic index of more than 32.8.
authors.affiliation: School of Life Science, Southwest University, Beibei, Chongqing, People's Republic of China.
authors.forename: Rong
authors.initials: R
authors.lastname: Sun
authors.forename: Hong-Chuan
authors.initials: HC
authors.lastname: Song
authors.forename: Chun-Ren
authors.initials: CR
authors.lastname: Wang
authors.forename: Kai-Ze
authors.initials: KZ
authors.lastname: Shen
authors.forename: Yao-Bo
authors.initials: YB
authors.lastname: Xu
authors.forename: Yan-Xiu
authors.initials: YX
authors.lastname: Gao
authors.forename: Ye-Gao
authors.initials: YG
authors.lastname: Chen
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Dong
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D006678:HIV / Q000187:drug effects*; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D019380:Anti-HIV Agents; D014315:Triterpenes