title: Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats.
abstract: This study was designed to investigate the therapeutic effect of sodium formononetin-3'-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase and cardiac troponin T in serum and reduced the myocardium necrosis scores. The number of apoptosis cardiocytes is well accordance with the up-regulated expression of Bcl-2 and the down-regulated expression of Bax. Meanwhile, Sul-F significantly increased the cardiac mitochondrial ATP content, improved ATP synthase activity, decreased thiobarbituric acid-reactive substances content and attenuated the decrease in superoxide dismutase and glutathione peroxidase activities. These findings indicate that Sul-F has a protective potential against myocardial infarction injury. A possible mechanism for the protective effect is the elevated expression of endogenous antioxidant defence enzymes degraded lipid peroxidation products and improved energy metholism of cardiac mitochondrial, thus attenuating cardiocyte apoptosis.
authors.affiliation: College of Life Science, Ocean University of China, Qingdao, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Zhang
authors.forename: Xuexi
authors.initials: X
authors.lastname: Tang
authors.forename: Jingwei
authors.initials: J
authors.lastname: Tian
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.forename: Guanbo
authors.initials: G
authors.lastname: Zhang
authors.forename: Wanglin
authors.initials: W
authors.lastname: Jiang
authors.forename: Zunting
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D004562:Electrocardiography / Q000187:drug effects; D019254:Genes, bcl-2 / Q000502:physiology; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D025261:Mitochondrial Proton-Translocating ATPases / Q000378:metabolism; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D020107:Troponin T / Q000097:blood / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: C494828:Bax protein, rat; D002316:Cardiotonic Agents; D007529:Isoflavones; D020107:Troponin T; D051028:bcl-2-Associated X Protein; C548268:formononetin-3-sulfonate; C007768:formononetin; D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D003402:Creatine Kinase; D025261:Mitochondrial Proton-Translocating ATPases