title: High-level polyomavirus JC viruria following long-term steroid therapy.
abstract: C virus is a highly seroprevalent ubiquitous polyomavirus which is acquired at an early age through respiratory or oral route, Thereafter JCV establishes persistent, but mainly asymptomatic, infections in various tissues, including the genitourinary tract and brain. In individuals with altered immunity, viral replication can occur leading to serious organ diseases. In contrast to polyomavirus BK, that is found infrequently in the urine of healthy adults, JC viruria occurs universally. Herein we describe a case of an otherwise immunocompetent patient who presented a very high-level asymptomatic polyomavirus JC viruria following long-term steroid therapy.
authors.affiliation: S.C.D.U. Virologia, Azienda Ospedaliero-Universitaria San Giovanni Battista di Torino. cristina.costa@unito.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Costal
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Bergallo
authors.forename: Paolo
authors.initials: P
authors.lastname: Ferrara
authors.forename: Rossana
authors.initials: R
authors.lastname: Cavallo
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D058070:Asymptomatic Diseases; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects; D004279:DNA, Viral / Q000652:urine; D004008:Diclofenac / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007577:JC Virus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000209:etiology / Q000652:urine* / Q000821:virology; D014412:Tumor Virus Infections / Q000209:etiology / Q000652:urine* / Q000821:virology; D014775:Virus Activation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004279:DNA, Viral; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D004008:Diclofenac; D001623:Betamethasone