title: Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection.
abstract: A new, simple and repeatable liquid chromatography method with charged aerosol detection (LC-CAD) for the determination of gentamicin sulphate composition and related substances has been developed. Gentamicin lacks of chromophores, therefore its determination is quite problematic. Using a universal CAD enables to achieve good separation without sample derivatization. Mass spectrometry was employed to confirm the LC-CAD peak profile. The proposed method was validated and applied for the determination of gentamicin sulphate composition and related substances in pharmaceutical preparations.
authors.forename: Karolina
authors.initials: K
authors.lastname: Stypulkowska
authors.forename: Agata
authors.initials: A
authors.lastname: Blazewicz
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Fijalek
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sarna