title: Evaluation of two polymeric blends (EVA/PLA and EVA/PEG) as coating film materials for paclitaxel-eluting stent application.
abstract: The ethylene vinyl acetate copolymer (EVA)/Poly (lactic acid) (PLA) blend and EVA/Poly (ethylene glycol) (PEG) blend were applied as the drug carrier materials for a bi-layer drug-loaded stent coating film, which consisted of a paclitaxel (PTX)-loaded layer and a drug-free EVA layer. The changes of weight and appearance of the drug-free polymeric blend films with increasing time were examined by X-ray diffraction analysis (XRD), gel permeation chromatography (GPC) tests and scanning electronic microscopy (SEM), and the results showed the degradation of PLA and the leaching of PEG from the films. The effects of PLA, PEG and drug contents on in vitro drug release were investigated, and the results demonstrated that the addition of PLA promoted the drug release while the addition of PEG almost did not. Franz cells diffusion test results indicated that the bi-layer structure successfully endowed the stent coating with the release of drug in a unidirectional fashion. The release profiles of films incorporated PTX and the mechanical performance of the film could be customized by readily adjusting the contents of the blend components. Therefore, the polymeric blends could be useful drug carrier materials for drug-loaded stent coating capable of releasing drug in a highly tunable manner.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Hou
authors.forename: Mu-Fei
authors.initials: MF
authors.lastname: Tang
authors.forename: Sheng-Rong
authors.initials: SR
authors.lastname: Guo
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Ke-Min
authors.initials: KM
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002850:Chromatography, Gel / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D054855:Drug-Eluting Stents; D019344:Lactic Acid / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D017239:Paclitaxel / Q000008:administration & dosage*; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013314:Stress, Mechanical; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D008051:Lipid Bilayers; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); D017239:Paclitaxel