title: Metabolic syndrome components and age-related cataract: the Singapore Malay eye study.
abstract: OBJECTIVE
  To examine the relationship between metabolic syndrome and its components, diabetes mellitus, high blood pressure (BP), obesity, and dyslipidemia, with age-related cataract.
  
  
  METHODS
  A population-based sample of 2794 Malay adults aged 40 to 80 years in Singapore was used for this analysis. Cataract (n = 1268) was defined as the presence of nuclear, cortical, or posterior subcapsular (PSC) cataract, from standardized grading of lens photographs or previous cataract surgery. Metabolic syndrome was defined as the presence of ≥ 3 of the following components: body mass index (BMI) ≥ 25 kg/m(2), triglycerides ≥ 1.7 mM, high density-lipoprotein (HDL) cholesterol <1.0 mM in men and <1.3 mM in women, BP ≥ 130/85 mm Hg, or use of BP medication and diabetes mellitus.
  
  
  RESULTS
  Cataract prevalence increased with higher quartiles of blood glucose, systolic BP, and metabolic syndrome components (P trend < 0.0001). The multivariable odds ratio (OR) (95% confidence interval [CI]) of cataract was 1.89 (1.42-2.40) for diabetes, 1.92 (1.47-2.52) for high BP, and 1.27 (1.04-1.55) for metabolic syndrome. Of the individual metabolic syndrome components, high BP was associated with all three cataract types; diabetes was associated with cortical and PSC; low HDL, high BMI, and metabolic syndrome were associated with cortical cataract. The presence of both high BP and diabetes was associated with fourfold odds of having cataract (OR [95% CI] = 4.73 [2.16-10.34]).
  
  
  CONCLUSIONS
  Metabolic syndrome and its two key components, high BP and diabetes were associated with age-related cataract.
authors.affiliation: Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
authors.forename: Charumathi
authors.initials: C
authors.lastname: Sabanayagam
authors.forename: Jie Jin
authors.initials: JJ
authors.lastname: Wang
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
authors.forename: Ava Grace
authors.initials: AG
authors.lastname: Tan
authors.forename: E Shyong
authors.initials: ES
authors.lastname: Tai
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
authors.forename: Seang-Mei
authors.initials: SM
authors.lastname: Saw
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D044466:Asian People / Q000208:ethnology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002386:Cataract / Q000150:complications* / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D050171:Dyslipidemias / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides