title: Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides.
abstract: Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as 'tags' coupled with Pd(0)-mediated Suzuki-Miyuara 'modification' has been enabled by discovery of an effective small molecule palladium scavenger.
authors.affiliation: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Spicer
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Davis
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000737:chemistry; D055162:Biocatalysis; D001897:Boronic Acids / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D002853:Chromatography, Liquid; D004492:Edetic Acid / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008024:Ligands; D058619:Maltose-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013058:Mass Spectrometry; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry*; D010649:Phenylalanine / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D002614:Chelating Agents; D005663:Furans; D006841:Hydrocarbons, Aromatic; D006846:Hydrocarbons, Halogenated; D008024:Ligands; D058619:Maltose-Binding Proteins; D010649:Phenylalanine; D010165:Palladium; D004492:Edetic Acid; D015097:3-Mercaptopropionic Acid