title: Effects of vitamin E on plasma lipid status and oxidative stress in Chinese women with metabolic syndrome.
abstract: Following the change of dietary structure and living style, metabolic syndrome (MetS) has become increasingly common in China, especially in women, who have abnormal plasma lipid profiles with increased levels of oxidative stress. Vitamin E (VitE) is a powerful chain-breaking antioxidant, which may be a protective factor against oxidative stress-related diseases. This study investigated the effects of three different dosages of tocopherol supplementation (100 IU /day, 200 IU /day, 300 IU /day) for 4 months in Chinese women with MetS. The plasma VitE concentrations increased significantly after the 4 months of supplementation (p < 0.01). The protective decreases in plasma total cholesterol were significant in 200 IU/day and 300 IU/day VitE groups (p < 0.05), but decreases in high-density lipoprotein cholesterol were also significant in all the supplementation groups (p < 0.05). Plasma triglycerides were unaltered (p > 0.05). The indicators of oxidative stress decreased substantially in all of the VitE supplementation groups: malondialdehyde (MDA) was reduced by nearly 50 percent (all groups, p < 0.001), erythrocyte hemolysis was decreased by nearly 40 percent (all groups, p < 0.05); among which the 300IU/day VitE group showed the most significant effect. However, the activity of superoxide dismutase (SOD) decreased after the trial (p < 0.001). VitE provided marked benefits in reducing oxidative stress levels and improving lipid status in women with MetS. Although no dose-effect relationship was observed, 300 IU VitE per day showed the optimal effect. Research is needed to identify potential protective mechanisms or utilization of vitamin E during MetS.
authors.affiliation: The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, China. kevin1971@yahoo.cn
authors.forename: Qiuzhen
authors.initials: Q
authors.lastname: Wang
authors.forename: Yongye
authors.initials: Y
authors.lastname: Sun
authors.forename: Aiguo
authors.initials: A
authors.lastname: Ma
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Xiuxia
authors.initials: X
authors.lastname: Han
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014810:Vitamin E; D008315:Malondialdehyde; D002784:Cholesterol; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol