title: Soluble MHC I and soluble MIC molecules: potential therapeutic targets for cancer.
abstract: It has become clear that soluble MHC I (sMHC I) and soluble MIC (sMIC), which are highly elevated in sera of cancer patients, can be viewed to be tolerogenic, and that metalloproteinases are involved in their generation process. In this review, an overview is provided of the recent progress made in the sMHC I and sMIC fields, with emphasis on their structure, formation, and function, and the key-questions that still await answers are addressed. Understanding better their formation mechanism, it will become more feasible to modulate the immune responses in cancer patients by targeting molecules involved in their generation process.
authors.affiliation: State Key Laboratory of Cancer Biology, Department of Pharmacogenomics, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
authors.forename: Jinrong
authors.initials: J
authors.lastname: Zhao
authors.forename: Yanhai
authors.initials: Y
authors.lastname: Guo
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yan
authors.forename: Ju
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuri
authors.initials: Y
authors.lastname: Bushkin
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
mesh_terms: D015395:Histocompatibility Antigens Class I / Q000097:blood / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D045726:Metalloproteases / Q000276:immunology / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000097:blood / Q000276:immunology*; D012995:Solubility; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen; D045726:Metalloproteases