title: [In vitro antimicrobial activity of piperacillin-sulbactam and other 7 antimicrobial agents against non-fermentative bacilli].
abstract: OBJECTIVE
  To evaluate the in vitro antimicrobial activity of piperacillin-sulbactam against clinical isolates of non-fermentative bacilli isolated from common infections.
  
  
  METHODS
  Microdilution was employed to study the antimicrobial resistance.
  
  
  RESULTS
  A total of 770 strains were collected from 6 hospitals in Guangzhou, including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia, Burkholderia cepacia, Flavobacterium, and Alcaligenes. Compared with other β-lactams, piperacillin-sulbactam displayed the highest activity against all the isolates of P.aeruginosa, especially for imipenem non-sensitive isolates, with the susceptibility of 71.9% and 55.8%, respectively. Piperacillin-sulbactam and cefoperazone-sulbactam kept good activity against imipenem sensitive isolates of A.baumannii, with the susceptibility of 71.0% and 73.0%, respectively. For the strains of Burkholderia cepacia, 69% strains exhibited minimal inhibitory concentration (MIC) of ≤ 16 mg/L for piperacillin-sulbactam. For the strains of Flavobacterium, and Alcaligenes, piperacillin-sulbactam also had excellent activity, with the susceptibility of 70.2% and 94.4%, respectively.
  
  
  CONCLUSIONS
  Piperacillin-sulbactam exhibits good activity again non-fermentative bacilli, especially for imipenem non-sensitive isolates of P.aeruginosa.
authors.affiliation: First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510230, China. chao_sheep@263.net
authors.forename: Chao
authors.initials: C
authors.lastname: Zhuo
authors.forename: Shu-nian
authors.initials: SN
authors.lastname: Xiao
authors.forename: Gui-xia
authors.initials: GX
authors.lastname: Qiu
authors.forename: Nan-shan
authors.initials: NS
authors.lastname: Zhong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013407:Sulbactam / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013407:Sulbactam; D010878:Piperacillin