title: Lateral augmentation of the mandible in minipigs with a synthetic nanostructured hydroxyapatite block.
abstract: The purpose of this study was to evaluate biomaterial degradation and new bone formation after implantation of a nanostructured hydroxyapatite (HA) grafting block. Furthermore, physical characteristics of the biomaterial were measured. The biomaterial consists of nanostructured HA embedded in a porous matrix of silica (SiO(2) ) gel. The blocks with two different contents of silica (group A: 24 wt % and group B: 39 wt %) were fixed with titanium screws at the lateral aspect of the mandible of minipigs (n = 5). The specific surface areas of both blocks were measured using Brunauer-Emmett-Teller (BET) equation and mercury intrusion. In all animals, the wound healing was uneventful. After 5 weeks, the biomaterial percentage was 51.5% ± 12.1% for group A and 33.2% ± 5.9% for group B (p = 0.017). New bone formation accounted to 7.6% ± 6.0% for group A and 15.3% ± 8.3% for group B (p = 0.126) after 5 weeks. After 10 weeks, further resorption of the biomaterial led to percentages of 30.6% ± 10.0% for group A and 12.1% ± 6.7% for group B (p = 0.000). After 10 weeks, new bone formations were measured to be 34.1% ± 10.8% in group A and 39.9% ± 13.5% in group B (p = 0.383). The rate of degradation of the biomaterial is controlled by the composition of the material. A higher content of silica gel matrix leads to faster degradation of the biomaterial. The formation of new bone failed to show a significant difference between both groups.
authors.affiliation: Department of Oral and Maxillofacial Plastic Surgery, University of Rostock, Schillingallee, Rostock, Germany. mkirchhoff@gmx.com
authors.forename: Mark
authors.initials: M
authors.lastname: Kirchhoff
authors.forename: Solvig
authors.initials: S
authors.lastname: Lenz
authors.forename: Kai-Olaf
authors.initials: KO
authors.lastname: Henkel
authors.forename: Bernhard
authors.initials: B
authors.lastname: Frerich
authors.forename: Gerd
authors.initials: G
authors.lastname: Holzhüter
authors.forename: Sven
authors.initials: S
authors.lastname: Radefeldt
authors.forename: Thomas
authors.initials: T
authors.lastname: Gerber
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D018786:Bone Substitutes; D017886:Durapatite / Q000627:therapeutic use*; D020007:Implants, Experimental; D008334:Mandible / Q000601:surgery*; D049329:Nanostructures / Q000627:therapeutic use; D010012:Osteogenesis; D058428:Silica Gel; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D058428:Silica Gel; D017886:Durapatite