title: Ultimate test bench for pediatric biventricular assist device based on artificial muscles.
abstract: Ventricular assist devices (VADs) are used in treatment for terminal heart failure or as a bridge to transplantation. We created biVAD using the artificial muscles (AMs) that supports both ventricles at the same time. We developed the test bench (TB) as the in vitro evaluating system to enable the measurement of performance. The biVAD exerts different pressure between left and right ventricle like the heart physiologically does. The heart model based on child's heart was constructed in silicone. This model was fitted with the biVAD. Two pipettes containing water with an ultrasonic sensor placed on top of each and attached to ventricles reproduced the preload and the after load of each ventricle by the real-time measurement of the fluid height variation proportionally to the exerted pressure. The LabVIEW software extrapolated the displaced volume and the pressure generated by each side of our biVAD. The development of a standardized protocol permitted the validation of the TB for in vitro evaluation, measurement of the performances of the AM biVAD herein, and reproducibility of data.
authors.affiliation: Department of Cardiovascular Surgery, Centre Hospitalier Univesitaire Vaud (CHUV), Lausanne, Switzerland. mirza.muradbegovic@chuv.ch
authors.forename: Mirza
authors.initials: M
authors.lastname: Muradbegovic
authors.forename: Steven
authors.initials: S
authors.lastname: Taub
authors.forename: Elena
authors.initials: E
authors.lastname: Rizzo
authors.forename: Ludwig K
authors.initials: LK
authors.lastname: von Segesser
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Tozzi
mesh_terms: D000367:Age Factors; D001187:Artificial Organs; D001696:Biomechanical Phenomena; D002648:Child; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery; D006353:Heart-Assist Devices / Q000706:statistics & numerical data; D006801:Humans; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D009132:Muscles; D011474:Prosthesis Design; D012984:Software