title: Why can seizures remain intractable? Clinical vignettes from the life experience of a pediatric epileptologist.
abstract: Most childhood seizures can be controlled by the appropriate antiepileptic drugs. When seizures remain intractable in a normally developing child with an intact neurologic examination, it is usually possible to identify a clear reason, and the physician, like a detective, needs to investigate and reveal it. In this article we will describe cases that were encountered during a lifetime at a pediatric epilepsy clinic, which will illustrate the different reasons seizures remain intractable in patients who do not have structural abnormalities or resistant epileptic syndromes.
authors.affiliation: Lerman Epilepsy Clinic, Tel Aviv, Israel.
authors.forename: Pinchas
authors.initials: P
authors.lastname: Lerman
authors.forename: Shira
authors.initials: S
authors.lastname: Sagie
authors.forename: Tally
authors.initials: T
authors.lastname: Lerman-Sagie
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D006801:Humans; D008306:Malingering / Q000175:diagnosis*; D012640:Seizures / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants