title: The NADPH oxidase Nox4 and aging in the heart.
abstract: Oxidative stress in mitochondria is believed to promote aging. Although passive leakage of electron from the mitochondrial electron transport chain has been considered as a major source of oxidative stress in the heart and the cardiomyocytes therein, enzymes actively producing reactive oxygen species may also exist in mitochondria. We have shown recently that Nox4, a member of the NADPH oxidase family, is localized on intracellular membranes, primarily at mitochondria, in cardiomyocytes. Mitochondrial expression of Nox4 is upregulated by cardiac stress and aging in the heart, where Nox4 could become a major source of oxidative stress. This raises an intriguing possibility that Nox4 may play an important role in mediating aging of the heart. Here we discuss the potential involvement of Nox4 in mitochondrial oxidative stress and aging in the heart.
authors.affiliation: Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ago
authors.forename: Shouji
authors.initials: S
authors.lastname: Matsushima
authors.forename: Junya
authors.initials: J
authors.lastname: Kuroda
authors.forename: Daniela
authors.initials: D
authors.lastname: Zablocki
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
authors.forename: Junichi
authors.initials: J
authors.lastname: Sadoshima
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics; D006801:Humans; D051379:Mice; D008929:Mitochondria, Heart / Q000201:enzymology*; D032383:Myocytes, Cardiac / Q000201:enzymology*; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D017382:Reactive Oxygen Species; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases; C422943:Nox4 protein, mouse