title: Elimination of blood group antigens: hope and reality.
abstract: In transfusion medicine, three major issues, i.e. heterogeneity of human blood groups, dependence of blood supply on donation, and shortage of some phenotypes, oblige clinicians to juggle with available biological material to avoid or limit post-transfusion reactions. This 'fact of life' has given impetus to a 30-year-old quest to achieve interchangeability of blood products between donors and recipients by eliminating blood group antigens.
authors.affiliation: Laboratoire Hématologie Moléculaire, Établissement Français du Sang Alpes Méditerranée, UMR 6578, Université de la Méditerranée, Marseille, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Bagnis
authors.forename: Jacques
authors.initials: J
authors.lastname: Chiaroni
authors.forename: Pascal
authors.initials: P
authors.lastname: Bailly
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000517:prevention & control*; D001788:Blood Grouping and Crossmatching / Q000379:methods / Q000639:trends; D001803:Blood Transfusion / Q000379:methods / Q000639:trends; D005818:Genetic Engineering / Q000379:methods; D006648:Histocompatibility / Q000187:drug effects / Q000235:genetics; D006801:Humans; D011092:Polyethylene Glycols / Q000494:pharmacology
chemical_list: D001789:Blood Group Antigens; D011092:Polyethylene Glycols