title: [Inflammatory biomarker for diagnosis of coronary diseases].
abstract: Acute coronary syndromes are multifactorial and occur in response to inflammation, plaque rupture and subsequent thrombosis, progressive mechanical obstruction, and dynamic obstruction. Among potential biomarkers, much interest has focused on biomarkers of inflammation. The process that leads to eventual plaque erosion or rupture involves a number of inflammatory mechanisms, including endothelial dysfunction, leukocyte migration, extracellular matrix degradation, and platelet activation. We discuss herein blood levels of adhesion molecules, matrix metalloproteases, monocyte chemoattractant protein-1, and tissue factor and interferon-gamma production of circulating T cell in patients with acute coronary syndromes. These biomarkers are associated with not only formation and progression of atherosclerotic plaque but also incidence of coronary event.
authors.affiliation: Health Care Center, Kumamoto University.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Soejima
authors.forename: Hideki
authors.initials: H
authors.lastname: Kishikawa
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D018932:Chemokine CCL2 / Q000097:blood*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008213:Lymphocyte Activation; D008262:Macrophage Activation; D020782:Matrix Metalloproteinases / Q000097:blood; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D018932:Chemokine CCL2; D007371:Interferon-gamma; D020782:Matrix Metalloproteinases