title: Association between interleukin-16 polymorphisms and risk of coronary artery disease.
abstract: Growing evidence has shown that inflammation plays crucial roles in the development of coronary artery disease (CAD). Interleukin-16 (IL-16), a multifunctional cytokine, is involved in a series of inflammatory disorders. The aim of this study was to investigate the association between IL-16 polymorphisms and risk of CAD. We analyzed two polymorphisms of IL-16 (rs4778889 T/C and rs11556218 T/G) in 157 patients with CAD and 202 healthy controls by using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. The TG/GG genotypes of rs11556218 T/G were associated with a significantly increased risk of CAD as compared with the TT genotype (odds ratio = 1.77; 95% confidence intervals, 1.16-2.71). This finding indicates that IL-16 may be used as a genetic marker for CAD susceptibility.
authors.affiliation: State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Longjiang
authors.initials: L
authors.lastname: Li
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D019410:Interleukin-16