title: Association of adiponectin, resistin, and vascular inflammation: analysis with 18F-fluorodeoxyglucose positron emission tomography.
abstract: OBJECTIVE
  Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis. (18)F-Fluorodeoxyglucose (FDG) positron emission tomography is a promising imaging technique that can be used to evaluate vascular inflammation.
  
  
  RESULTS
  We measured adiponectin and resistin levels, as well as traditional cardiovascular risk factors, in 60 obese subjects and 60 nonobese controls. In addition, we compared carotid intima-media thickness and target-to-background ratio (TBR) measured using (18)F-fluorodeoxyglucose-positron emission tomography/computed tomography. The mean TBR values were significantly higher in the obese group compared with normal subjects, although their mean carotid intima-media thickness levels were not significantly different. Serum adiponectin levels showed a significant negative correlation with mean TBR values (r = -0.215, P = 0.020), whereas resistin levels were positively correlated with mean TBR values (r = 0.214, P = 0.021). Multiple linear regression analysis showed that mean TBR values were independently associated with body mass index, high-sensitivity C-reactive protein, and resistin levels (R(2) = 0.308).
  
  
  CONCLUSIONS
  Adiponectin and resistin may be useful as biomarkers to reflect vascular inflammation. In particular, resistin levels were independently associated with vascular inflammation even after adjusting for other cardiovascular risk factors.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hae Yoon
authors.initials: HY
authors.lastname: Choi
authors.forename: Sungeun
authors.initials: S
authors.lastname: Kim
authors.forename: Sae Jeong
authors.initials: SJ
authors.lastname: Yang
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Ji A
authors.initials: JA
authors.lastname: Seo
authors.forename: Sin Gon
authors.initials: SG
authors.lastname: Kim
authors.forename: Nan Hee
authors.initials: NH
authors.lastname: Kim
authors.forename: Sei Hyun
authors.initials: SH
authors.lastname: Baik
authors.forename: Dong Seop
authors.initials: DS
authors.lastname: Choi
authors.forename: Kyung Mook
authors.initials: KM
authors.lastname: Choi
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D056910:Republic of Korea; D052243:Resistin / Q000097:blood*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; C499624:RETN protein, human; D019275:Radiopharmaceuticals; D052243:Resistin; D019788:Fluorodeoxyglucose F18