title: Approaches to immunotherapies for Japanese cedar pollinosis.
abstract: Japanese cedar (Cryptomeria japonica; CJ) pollinosis is a typical type I allergy induced by CJ pollen and one of the most common allergic diseases in Japan. New immunotherapies have been developed for treatment of CJ pollinosis. We focus here on new immunotherapies for CJ pollinosis including sublingual immunotherapy with crude extract of CJ antigen, oral immunotherapy with transgenic rice expressing CJ allergens, a peptide vaccine using T cell epitopes of CJ allergens, DNA vaccines encoding either the CJ allergen gene or T cell epitope gene, and adjuvant-conjugated vaccines using CJ allergen conjugated with adjuvants such as CpG oligodeoxynucleotide or pullulan.
authors.affiliation: Department of Veterinary Microbiology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan. sakagum@azabu-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hirahara
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
authors.forename: Masako
authors.initials: M
authors.lastname: Toda
mesh_terms: D000284:Administration, Oral; D000286:Administration, Sublingual; D000485:Allergens / Q000235:genetics / Q000378:metabolism; D000818:Animals; D032485:Cryptomeria / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends*; D051379:Mice; D008822:Mice, Transgenic; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy*; D018074:Vaccines, Conjugate / Q000627:therapeutic use; D019444:Vaccines, DNA / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000485:Allergens; D018984:Epitopes, T-Lymphocyte; D018074:Vaccines, Conjugate; D019444:Vaccines, DNA