title: DBCAT: database of CpG islands and analytical tools for identifying comprehensive methylation profiles in cancer cells.
abstract: DBCAT (database of CpG islands and analytical tools, http://dbcat.cgm.ntu.edu.tw/ ), developed to characterize comprehensive DNA methylation profiles in human cancers, is a web-based application and methylation database containing several convenient tools for investigating epigenetic regulation in human diseases. To our knowledge, DBCAT is the first online methylation analytical tool, and is composed of three parts: a CpG island finder, a genome query browser, and a tool for analyzing methylation microarray data. The analytical tools can quickly identify genes with methylated regions from microarray data, compare the methylation status changes between different arrays, and provide functional analysis in addition to colocalizing transcription factor binding sites.
authors.affiliation: Research Center For Medical Excellence, National Taiwan University, Taipei, Taiwan.
authors.forename: Hsien-Chi
authors.initials: HC
authors.lastname: Kuo
authors.forename: Po-Yu
authors.initials: PY
authors.lastname: Lin
authors.forename: Ting-Chiun
authors.initials: TC
authors.lastname: Chung
authors.forename: Chin-Mei
authors.initials: CM
authors.lastname: Chao
authors.forename: Liang-Chuan
authors.initials: LC
authors.lastname: Lai
authors.forename: Mong-Hsun
authors.initials: MH
authors.lastname: Tsai
authors.forename: Eric Y
authors.initials: EY
authors.lastname: Chuang
mesh_terms: D001665:Binding Sites; D018899:CpG Islands; D019175:DNA Methylation / Q000235:genetics*; D030541:Databases, Genetic / Q000600:supply & distribution*; D057890:Epigenomics / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D012984:Software; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D014157:Transcription Factors