title: [Expression of PLAC1/CP1 genes in primary colorectal carcinoma and its clinical significance].
abstract: OBJECTIVE
  To study the expression and significance of PLAC1/CP1 genes in patients with primary colorectal carcinoma.
  
  
  METHODS
  The expression of PLAC1/CP1 genes in 97 cases of colorectal carcinoma was studied using tissue chip technology and immunohistochemistry.
  
  
  RESULTS
  The rate of PLAC1/CP1 proteins expression in the cases studied was 56.7% (55/97), with 27.8% (27/97) being nuclear staining and 43.3% (42/97) being cytoplasmic staining. The percentage of expression was higher in women than in men (χ(2) = 6.567, P = 0.010). The expression in poorly differentiated colorectal carcinoma was significantly higher than that in the well or moderately differentiated carcinoma (χ(2) = 8.321, P = 0.016). The expression was also significantly higher in stage TNM III or IV tumors than in stage TNM I or II tumors (χ(2) = 18.726, P = 0.000). The rate was higher in cases with lymph node metastasis than in those with negative lymph nodes (χ(2) = 17.407, P = 0.000), and was higher as the number of metastasis increasing (χ(2) = 22.632, P = 0.000).
  
  
  CONCLUSIONS
  The expression of PLAC1/CP1 genes correlates with various clinical and pathologic parameters. It carries prognostic significance and may represent a potential target for immunotherapy.
authors.affiliation: Department of Pathology, Peking University People's Hospital, Beijing 100044, China. liufangfang@pkuph.edu.cn
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Liu
authors.forename: Dan-Hua
authors.initials: DH
authors.lastname: Shen
authors.forename: Shan
authors.initials: S
authors.lastname: Wang
authors.forename: Ying-Jiang
authors.initials: YJ
authors.lastname: Ye
authors.forename: Qiu-Jing
authors.initials: QJ
authors.lastname: Song
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011257:Pregnancy Proteins / Q000378:metabolism*; D012737:Sex Factors
chemical_list: C415583:PLAC1 protein, human; D011257:Pregnancy Proteins