title: Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.
abstract: BACKGROUND
  analgesics in pediatric ambulatory surgery must be safe and effective. Acetominophen is safe with moderate efficacy; therefore, we searched for other drugs. In preclinical trials, improved efficacy was reported with the combination of acetaminophen + B vitamins. The aim of this study was to determine the analgesic efficacy of acetaminophen + B vitamins in pediatric ambulatory surgery.
  
  
  METHODS
  we conducted a clinical, comparative, randomized, double-blind study. We included 56 patients who were divided into four groups of 14 patients for each surgery (circumcision, tonsillectomy, inguinal hernioraphy, orchiopexy). Half of the patients received acetaminophen + B vitamins, and the remaining patients received acetaminophen alone. Variables were drugs, visual analogue scale and time of discharge. χ(2), Student t-test and analysis of variance (ANOVA) were used for statistical analysis.
  
  
  RESULTS
  in children who received acetaminophen + B vitamins during the immediate postoperative period, 58% had a pain score <2 and 89% were discharged with a pain score %lt;1. Both schedules were effective and safe but acetaminophen + B vitamins showed a better pain score.
  
  
  CONCLUSIONS
  the adjuvant effect of B vitamins was demonstrated with a better pain score in the immediate postoperative period and at the time of discharge.
authors.affiliation: Subdirección de Pediatría, Hospital General "Dr. Manuel Gea González," Secretaría de Salud, México, D. F., Mexico. gamagq3@hotmail.com
authors.forename: Alfonso
authors.initials: A
authors.lastname: Galván-Montaño
authors.forename: Gerardo
authors.initials: G
authors.lastname: Reyes-García
authors.forename: María de Lourdes
authors.initials: Mde L
authors.lastname: Suárez-Roa
authors.forename: Juan
authors.initials: J
authors.lastname: Asbun-Bojalil
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000556:Ambulatory Surgical Procedures; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D018712:Analgesics, Non-Narcotic; D014803:Vitamin B Complex; D000082:Acetaminophen