title: [Clinical evaluation of the combination treatment of intrapleural or intraperitoneal administration of lentinan and OK-432 for malignant effusion].
abstract: The combination treatment of non-specific immunomodulator Lentinan (LNT) and OK-432 is effective for controlling Th1/Th2 balance and inducing Th1 dominant status in cancer patients. According to this rationale, we tried an administration of LNT and OK-432 in the pleural or peritoneal cavity for patients with malignant effusion. In all 21 lesions of the 20 cases, 10 revealed a complete disappearance and 7 revealed diminution of the effusion. The efficacy of this treatment is 81%. All patients developed a clinical efficacy in 1 to 3 courses of this treatment, and 9 lesions developed clinical efficacy in only 1 course. None of patients developed toxic symptoms LNT, and 10 developed a low grade fever by OK-432. The combination of LNT and OK-432 is effective and for QOL conserving loco-regional treatment.
authors.affiliation: Dept. of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine.
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Yoshino
authors.forename: Shin
authors.initials: S
authors.lastname: Yoshida
authors.forename: Noriko
authors.initials: N
authors.lastname: Maeda
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Maeda
authors.forename: Kazunari
authors.initials: K
authors.lastname: Maeda
authors.forename: Shoichi
authors.initials: S
authors.lastname: Hazama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Oka
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D007274:Injections, Intraperitoneal; D007912:Lentinan / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage*; D035422:Pleural Cavity; D016066:Pleural Effusion, Malignant / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D007912:Lentinan; D010844:Picibanil