title: A moderate intensity exercise program did not increase the oxidative stress in older adults.
abstract: Oxidative damage to lipoproteins, in particular low density lipoprotein (LDL), is known to play a role in a number of diseases associated with aging such as cardiovascular disease (CVD) and dementia. Exercise can alter the balance of oxidative and anti-oxidative species within the human body and may cause oxidative damage to lipoproteins. The purpose of this study was to assess the effect of a moderate intensity exercise program on markers of oxidative stress in older age adults. Parameters of lipoprotein protein and lipid oxidation, and lipoprotein nitration were assessed in aged individuals who undertook a program of moderate physical activity for a period of 8 weeks. There were no significant changes in LDL protein oxidation or nitration which could be attributed to 8 weeks of walking exercise, however, LDL nitration was increased following acute steady state exercise (pre-: 0.34±0.1 vs. post-: 0.44±0.07 μm/mg LDL; p=0.04). Walking at moderate intensity caused a significant weight decrease in the exercise group, but did not have any significant effect on VO2max. Exercise at this intensity was not harmful and did not increase risk factors for diseases associated with oxidative stress in the participants of the study.
authors.affiliation: School of Sport and Exercise Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. s.aldred.1@bham.ac.uk
authors.forename: Sarah
authors.initials: S
authors.lastname: Aldred
authors.forename: Manjit
authors.initials: M
authors.lastname: Rohalu
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D011795:Surveys and Questionnaires; D016138:Walking; D015431:Weight Loss
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein