title: Lupinacidin C, an inhibitor of tumor cell invasion from Micromonospora lupini.
abstract: A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses, and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Saeko
authors.initials: S
authors.lastname: Yanase
authors.forename: Kohei
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Enomoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Miyanaga
authors.forename: Martha E
authors.initials: ME
authors.lastname: Trujillo
authors.forename: Ikuo
authors.initials: I
authors.lastname: Saiki
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Kuwahara
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001485:Basement Membrane / Q000187:drug effects; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D031297:Lupinus / Q000382:microbiology; D051379:Mice; D008847:Micromonospora / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053204:Root Nodules, Plant / Q000382:microbiology; D013030:Spain; D013237:Stereoisomerism
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; C559020:lupinacidin C