title: Recurrent fever syndromes in patients after recovery from Kawasaki syndrome.
abstract: The recurrence of fever in a child with a history of Kawasaki syndrome (KS) poses a dilemma for clinicians who must consider the possibility of recurrent KS. In this report we present the cases of 4 patients who presented with classical symptoms of KS, were successfully treated with intravenous immunoglobulin, and later experienced a reappearance of inflammatory symptoms in a pattern consistent with a recurrent fever syndrome. The association of these syndromes within the same patient suggests that some patients may have a genetic propensity toward altered immune responses and autoinflammatory syndromes. We propose that these 2 syndromes exist within a family of febrile disorders related to innate immune dysregulation.
authors.affiliation: Department of Pediatrics, University of California San Diego and Rady Children’s Hospital, San Diego, California, USA. lbroderick@ucsd.edu
authors.forename: Lori
authors.initials: L
authors.lastname: Broderick
authors.forename: Adriana H
authors.initials: AH
authors.lastname: Tremoulet
authors.forename: Jane C
authors.initials: JC
authors.lastname: Burns
authors.forename: John F
authors.initials: JF
authors.lastname: Bastian
authors.forename: Hal M
authors.initials: HM
authors.lastname: Hoffman
mesh_terms: D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D012008:Recurrence
chemical_list: D016756:Immunoglobulins, Intravenous