title: Association of inflammatory and oxidative stress markers with metabolic syndrome in asian indians in India.
abstract: Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P < .0001), Neopterin (P = .036), and oxLDL (P < .0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504-9.810; P < .0001) followed by hsCRP (OR 1.324 95% CI 1.070-1.638; P = .010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population.
authors.affiliation: Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, Narayana Hrudayalaya, 258/A Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, India.
authors.forename: Veena S
authors.initials: VS
authors.lastname: Rao
authors.forename: Radhika K
authors.initials: RK
authors.lastname: Nagaraj
authors.forename: Sridhara
authors.initials: S
authors.lastname: Hebbagodi
authors.forename: Natesha B
authors.initials: NB
authors.lastname: Kadarinarasimhiah
authors.forename: Vijay V
authors.initials: VV
authors.lastname: Kakkar