title: Early and delayed effects of hypoxia during the infantile period on behavioral and hormonal reactions of rats.
abstract: We studied the early and delayed effects of hypoxia during the infantile period on the behavioral reactions and corticosterone concentration in male rats. The elevation of corticosterone concentration, decrease in the immobility time (forced swimming test), and increase in the nociceptive response (formalin test) were observed in 7-day-old rats immediately after hypoxia. Adult animals exposed to hypoxia at the age of 7 days exhibited elevated basal corticosterone level and lengthened immobility time. Hypoxia had the same effect on plasma corticosterone concentration in 7-day-old and adult rats. Changes in corticosterone concentration after forced swimming were shown to differ in hypoxic animals and non-hypoxic specimens. Studying the dynamics of age-related variations in the test parameters will contribute to the understanding of pathogenetic mechanisms and development of new methods for pharmacological correction of postnatal changes in CNS after hypoxia during early ontogeny.
authors.affiliation: Laboratory for Ontogeny of Nervous System, Laboratory of Experimental Endocrinology, I P Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. viktormikhailenko@yandex.ru
authors.forename: V A
authors.initials: VA
authors.lastname: Mikhailenko
authors.forename: I P
authors.initials: IP
authors.lastname: Butkevich
authors.forename: T R
authors.initials: TR
authors.lastname: Bagaeva
authors.forename: G V
authors.initials: GV
authors.lastname: Makukhina
authors.forename: V A
authors.initials: VA
authors.lastname: Otellin
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood*; D003863:Depression / Q000209:etiology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010147:Pain Measurement; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological; D013550:Swimming
chemical_list: D003345:Corticosterone