title: Assessment of cerebral hemodynamics to acetazolamide using brain perfusion SPECT in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
abstract: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy caused by mutations in the Notch3 gene located on chromosome 19, leading to 4 cardinal features with aura, cerebrovascular ischemic events, mood disturbances, and dementia. Acetazolamide (ACZ) has been promoted as a drug to determine cerebral hemodynamics, including cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in patients with cerebrovascular disease. In CADASIL patients with small-vessel disease, ACZ may be possible to increase CBF. We present that reduced CBF was dramatically improved after administration of ACZ on Tc-99m ECD brain perfusion SPECT in a CADASIL patient.
authors.affiliation: Department of Nuclear Medicine, Wonkwang University College of Medicine and Institute of Wonkwang Medical Science, Iksan, Republic of Korea.
authors.forename: Soon-Ah
authors.initials: SA
authors.lastname: Park
authors.forename: Chung-Yong
authors.initials: CY
authors.lastname: Yang
authors.forename: See-Sung
authors.initials: SS
authors.lastname: Choi
authors.forename: Woo Hyoung
authors.initials: WH
authors.lastname: Kim
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000187:drug effects; D046589:CADASIL / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D055420:Perfusion Imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000086:Acetazolamide