title: Utility of ¹¹C-choline imaging as a supplement to F-18 FDG PET imaging for detection of thyroid carcinoma.
abstract: OBJECTIVE
  We present 4 patients with thyroid carcinoma who underwent ¹¹C-choline PET/CT for the detection of their primary tumor and its metastases. Previous F-18 FDG PET had shown no abnormal tracer uptake in the lesions in 3 patients and only mild uptake in 1 patient.
  
  
  METHODS
  Four patients aged between 24 and 59 years (2 newly diagnosed and 2 with recurrence) underwent whole-body F-18 FDG PET/CT. The patients then underwent regional ¹¹C-choline PET/CT imaging on a separate day.
  
  
  RESULTS
  All of the lesions in 4 patients were ¹¹C-choline avid except for a few small lung metastases. The SUVmax of the lesions was 7.94 ± 4.93. ¹¹C-choline imaging detected 3 primary tumors in 4 patients, 1 tumor in the tracheal wall in 1 patient, 7 cervical lymph nodes metastases in 3 patients, and several lung metastases in 1 patient.
  
  
  CONCLUSIONS
  ¹¹C-choline PET/CT may be a promising supplement to F-18 FDG PET/CT in the detection of thyroid carcinoma and its metastases.
authors.affiliation: NanFang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Hu-bing
authors.initials: HB
authors.lastname: Wu
authors.forename: Quan-shi
authors.initials: QS
authors.lastname: Wang
authors.forename: Min-fang
authors.initials: MF
authors.lastname: Wang
authors.forename: Hong-sheng
authors.initials: HS
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D002794:Choline; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D012008:Recurrence; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D002250:Carbon Radioisotopes; D019788:Fluorodeoxyglucose F18; D002794:Choline