title: Effects of change in fatigue and depression on physical activity over time in relapsing-remitting multiple sclerosis.
abstract: This prospective, observational study examined the effects of change in the symptoms of fatigue and depression on physical activity over time in persons with relapsing-remitting multiple sclerosis (RRMS). Adults with a confirmed diagnosis of RRMS completed a battery of questionnaires at baseline (n = 269) and six-month follow-up (n = 263). The data were analyzed using linear panel analysis and covariance modeling in Mplus 3.0. The panel model fit the data (χ(2) = 24.00, df = 15, p = 0.07, SRMR = 0.04, CFI = 0.98) and demonstrated that changes in both fatigue (path coefficient = -0.09) and depressive symptoms (path coefficient = -0.12) were significantly associated with residual change in physical activity. Such findings support the importance of fatigue and depression for predicting longitudinal changes in physical activity in adults with RRMS.
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA. robmotl@uiuc.edu
authors.forename: Robert W
authors.initials: RW
authors.lastname: Motl
authors.forename: Edward
authors.initials: E
authors.lastname: McAuley
authors.forename: Daniel
authors.initials: D
authors.lastname: Wynn
authors.forename: Yoojin
authors.initials: Y
authors.lastname: Suh
authors.forename: Madeline
authors.initials: M
authors.lastname: Weikert
mesh_terms: D016009:Chi-Square Distribution; D003863:Depression / Q000523:psychology*; D005221:Fatigue / Q000523:psychology*; D006801:Humans; D009043:Motor Activity; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000523:psychology*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires