title: Morphofunctional characteristics of fetoplacental barrier of placental villi during pregnancy complicated by herpes-virus infection.
abstract: Analysis of placenta homogenate from pregnant women having an episode of herpes-virus infection during the third trimester revealed suppression of Bcl-2 protein activity and increase in caspase 3 concentration. Activity of Bcl-2 protein decreases with increasing the titer of antibodies to herpes virus. Increased caspase-3 activity increases the risk of DNA damage in syncytiotrophoblast nuclei.
authors.affiliation: Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of Russian Academy of Medical Sciences, Blagoveshchensk, Amur region, Russia. lucenkomt@mail.ru
authors.forename: M T
authors.initials: MT
authors.lastname: Lutsenko
authors.forename: I A
authors.initials: IA
authors.lastname: Andrievskaya
mesh_terms: D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D002824:Chorionic Villi / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006561:Herpes Simplex / Q000378:metabolism / Q000473:pathology*; D018259:Herpesvirus 1, Human; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism / Q000473:pathology*; D011263:Pregnancy Trimester, Third; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D053148:Caspase 3