title: Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers.
abstract: OBJECTIVE
  To identify biomarkers for cancer in asbestosis patients.
  
  
  METHODS
  SELDI-TOF and CART were used to identify serum biomarker profiles in 35 asbestosis patients who subsequently developed cancer and 35 did not develop cancer.
  
  
  RESULTS
  Three polypeptide peaks (5707.01, 6598.10, and 20,780.70 Da) could predict the development of cancer with 87% sensitivity and 70% specificity. The first two peaks were identified as KIF18A and KIF5A, respectively, and are part of the Kinesin Superfamily of proteins.
  
  
  CONCLUSIONS
  We identified two Kinesin proteins that can be potentially used as blood biomarkers to identify asbestosis patients at risk of developing lung cancer.
authors.affiliation: Division of Allergy and Clinical Immunology, University of Colorado Denver, Aurora, CO 80045, USA. Brian.Tooker@ucdenver.edu
authors.forename: Brian C
authors.initials: BC
authors.lastname: Tooker
authors.forename: Lee S
authors.initials: LS
authors.lastname: Newman
authors.forename: Russell P
authors.initials: RP
authors.lastname: Bowler
authors.forename: Antti
authors.initials: A
authors.lastname: Karjalainen
authors.forename: Panu
authors.initials: P
authors.lastname: Oksa
authors.forename: Harri
authors.initials: H
authors.lastname: Vainio
authors.forename: Eero
authors.initials: E
authors.lastname: Pukkala
authors.forename: Paul W
authors.initials: PW
authors.lastname: Brandt-Rauf
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D000077192:Adenocarcinoma of Lung; D001195:Asbestosis / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005387:Finland; D006801:Humans; D016547:Kinesins / Q000097:blood*; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D040901:Proteomics; D012307:Risk Factors; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; C500506:KIF5A protein, human; C502735:KIF18A protein, human; D016547:Kinesins