title: Assessment of the biocompatibility of two novel, bionanocomposite scaffolds in a rodent model.
abstract: Two novel, bionanocomposite scaffolds were evaluated in a rodent model over the course of three months to determine whether these scaffolds possessed adequate biocompatibility characteristics to warrant further evaluation as possible tissue reconstruction scaffolds. These bionanocomposite scaffolds were comprised of amine-functionalized gold nanoparticles (AuNP) or silicon carbide nanowires (SiCNW) crosslinked to an acellular porcine diaphragm tendon. It was hypothesized that the addition of nanomaterials to the porcine tendon would also improve its biocompatibility by imparting a nanostructured surface. As early as seven days after implantation, both types of bionanocomposite scaffolds displayed evidence of granulation tissue and the beginning of scaffold remodeling with new collagen deposited by the host, and by ninety-seven days the bionanocomposite scaffolds were completely remodeled with no evidence of any adverse host tissue reaction or scar tissue formation. The AuNP bionanocomposite scaffolds exhibited accelerated scaffold remodeling compared to the SiCNW scaffolds.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Deeken
authors.forename: M
authors.initials: M
authors.lastname: Esebua
authors.forename: S L
authors.initials: SL
authors.lastname: Bachman
authors.forename: B J
authors.initials: BJ
authors.lastname: Ramshaw
authors.forename: S A
authors.initials: SA
authors.lastname: Grant
mesh_terms: D000588:Amines; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D017554:Carbon Compounds, Inorganic; D006046:Gold; D020007:Implants, Experimental; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D053761:Nanocomposites / Q000737:chemistry* / Q000627:therapeutic use; D053770:Nanowires / Q000737:chemistry / Q000627:therapeutic use*; D017655:Silicon Compounds; D013552:Swine; D013710:Tendons / Q000637:transplantation*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000588:Amines; D001672:Biocompatible Materials; D017554:Carbon Compounds, Inorganic; D017655:Silicon Compounds; D006046:Gold; C022088:silicon carbide