title: DNA-damage response in tissue-specific and cancer stem cells.
abstract: Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to address DNA damage, and describe how these mechanisms can impact SC genomic integrity by potentially promoting aging, tissue atrophy, and/or cancer development. Finally, we will discuss how similar mechanisms operate in cancer stem cells (CSCs) and can mediate resistance to chemo- and radiotherapy.
authors.affiliation: Université Libre de Bruxelles, IRIBHM, B1070 Bruxelles, Belgium. cedric.blanpain@ulb.ac.be
authors.forename: Cedric
authors.initials: C
authors.lastname: Blanpain
authors.forename: Mary
authors.initials: M
authors.lastname: Mohrin
authors.forename: Panagiota A
authors.initials: PA
authors.lastname: Sotiropoulou
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Passegué
mesh_terms: D000375:Aging; D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000378:metabolism; D015398:Signal Transduction