title: Treatment of adenovirus hepatitis with cidofovir in a pediatric liver transplant recipient.
abstract: AdV hepatitis is a rarely reported complication after pediatric liver transplantation that is associated with high rates of morbidity, mortality and graft failure. Successful treatment of AdV relies on early diagnosis of disease by quantitative PCR measurement of adenoviral DNA in blood and histological evidence in tissue biopsy. Pharmacologic treatment largely consists of antiviral therapy with CDV, an acyclic nucleoside phosphonate analog and reduction in immunosuppression. This report describes a case of AdV hepatitis in a pediatric liver transplant recipient successfully treated with a modified, renal sparing dosing of CDV.
authors.affiliation: Surgery, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Bayindir
authors.initials: B
authors.lastname: Cimsit
authors.forename: Eric M
authors.initials: EM
authors.lastname: Tichy
authors.forename: Sonya B
authors.initials: SB
authors.lastname: Patel
authors.forename: Richard
authors.initials: R
authors.lastname: Rosencrantz
authors.forename: Sukru
authors.initials: S
authors.lastname: Emre
mesh_terms: D000256:Adenoviridae / Q000378:metabolism*; D000998:Antiviral Agents / Q000494:pharmacology; D001706:Biopsy / Q000379:methods; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D006505:Hepatitis / Q000188:drug therapy* / Q000628:therapy / Q000821:virology*; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D063065:Organophosphonates / Q000494:pharmacology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D004247:DNA; D000077404:Cidofovir