title: Human Papillomavirus in Brazilian women with and without cervical lesions.
abstract: BACKGROUND
  Human Papillomavirus (HPV) high-risk (HR) types are the causal factor for cervical cancer and premalignant dysplasia. Data on frequency of HPV types provide a basis to design and evaluate HPV prevention programs. Taking into account the heterogeneity of HPV types across and within populations this study aims to access the HPV frequency in Brazilian women.
  
  
  RESULTS
  We identified 24 different types of HPV, including a Betapapillomavirus and a likely new type, previously reported, from 132 women positive for the virus analysed by Hybrid Capture II assay. These women were infected by a single or multiple HPV types and 142 HPV strains were identified. HR types were found in 75% of women and HPV types 16, 18, 45, 58, and 66 had the highest frequency. Significant differences in frequency of HR HPV types were found for presence of cervical lesions, and for different HPV species and women age.
  
  
  CONCLUSIONS
  Compared with previous studies in Brazil, our data indicated differences in frequency and HPV type diversity, a significant association of other HR-types but HPV16 and 18 and cervical lesions, and a trend for distinct distribution of HPV types by age.
authors.affiliation: Genetics Division, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. miguelm@inca.gov.br.
authors.forename: Michelle
authors.initials: M
authors.lastname: Oliveira-Silva
authors.forename: Camila X
authors.initials: CX
authors.lastname: Lordello
authors.forename: Lucília M G
authors.initials: LM
authors.lastname: Zardo
authors.forename: Cibele R
authors.initials: CR
authors.lastname: Bonvicino
authors.forename: Miguel A M
authors.initials: MA
authors.lastname: Moreira
mesh_terms: D000328:Adult; D001938:Brazil; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D011247:Pregnancy; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000821:virology