title: A general approach to N-heterocyclic scaffolds using domino Heck-aza-Michael reactions.
abstract: Palladium-catalyzed domino Heck-aza-Michael reactions for the synthesis of a series of C1-substituted tetrahydro-β-carbolines, tetrahydroisoquinolines and isoindolines are described. The domino process involves the initial intermolecular Heck reaction of an aryl bromide with an electron deficient alkene, followed by an intramolecular aza-Michael reaction to form the new N-heterocycle in high yield.
authors.affiliation: School of Life and Environmental Sciences, Deakin University, Geelong, 3217, Victoria, Australia.
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Priebbenow
authors.forename: Scott G
authors.initials: SG
authors.lastname: Stewart
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Pfeffer