title: Epstein-barr virus-positive diffuse large B-cell lymphoma of the elderly: what we know so far.
abstract: Epstein-Barr virus-positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a "provisional" entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. We will review and discuss the incidence of EBV expression in DLBCL, the pathogenesis behind EBV-driven malignant transformation of B cells, the different EBV latency patterns associated with DLBCL, the distinct pathologic characteristics of EBV-positive DLBCL, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity, which is characterized by a suboptimal response to therapy and poor survival rate.
authors.affiliation: The Miriam Hospital, 164 Summit Avenue, Providence, Rhode Island 02906, USA. jcastillo@lifespan.org
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
authors.forename: Brady E
authors.initials: BE
authors.lastname: Beltran
authors.forename: Roberto N
authors.initials: RN
authors.lastname: Miranda
authors.forename: Semra
authors.initials: S
authors.lastname: Paydas
authors.forename: Eric S
authors.initials: ES
authors.lastname: Winer
authors.forename: James N
authors.initials: JN
authors.lastname: Butera
mesh_terms: D000368:Aged; D002472:Cell Transformation, Viral; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000821:virology*; D011379:Prognosis