title: [Follow-up review on the long-term effect of composite transplantation of allogeneic acellular dermal matrix and split thickness skin autograft].
abstract: OBJECTIVE
  To review the long-term clinical effect of composite transplantation of allogeneic acellular dermal matrix (ADM) and split thickness skin autograft (STSG).
  
  
  METHODS
  Nineteen patients with 34 wounds transplanted with allogeneic ADM combined with STSG who were hospitalized from March 2001 to October 2008 were enrolled as composite transplantation group (CT). Another 9 patients with 11 wounds transplanted with STSG admitted within the same time frame were enrolled as control group (C). All patients were followed up for longer than 2 years. Color, evenness, texture, contracture, sensation, and complications of transplanted skin were assessed using a modified Manchester Scar Scale (1-4 scores, the higher the score, the poorer the situation). The scar formation on skin donor sites was assessed by the Vancouver Scar Scale. Patients' degree of satisfaction and health status during the transplantation period were investigated in the form of questionnaire. The skin tissue structure of 4 patients was observed with histological method. The joint range of motion was assessed by the neutral position before and after operation and at follow-up. Data were processed with nonparametric test, chi-square test or t test.
  
  
  RESULTS
  (1) The evenness, contracture, and texture of transplanted skin in CT group scored (1.6 ± 0.5), (1.8 ± 0.8), and (1.5 ± 0.8), respectively, which were significantly lower than those in C group [(2.0 ± 0.7), (2.2 ± 0.9), and (2.3 ± 0.7), with Z value respectively -2.058, -2.220, -2.323, P values all below 0.05]. Scores of color, sensation, and complications of transplanted skin in two groups were close to each other (with Z value respectively -0.628, -0.428, -2.520, P values all above 0.05). (2) Mild scar formation was observed in one of the skin donor sites in CT group. (3) Information as obtained from questionnaire showed no statistical difference between two groups in pinching, itching, and satisfaction degree (with χ(2) value respectively 0.187, 0.019, 2.628, P values all above 0.05). (4) Nerve fibers were seen in hand tissue 2 years after operation. ADM did not induce severe inflammatory responses in the site of grafting. (5) Eleven joints in CT group recovered or improved in function; while the other two joints required secondary surgery. Obvious contracture was observed in the two joints in C group.
  
  
  CONCLUSIONS
  Allogeneic ADM combined with STSG transplantation prevents scar contracture and has obvious effect in improving function and appearance. There is no problem in regard to safety for its existence in either adult or children.
authors.affiliation: Department of Burns, Hai'nan Provincial People's Hospital, Haikou 570311, China.
authors.forename: Yun-Chuan
authors.initials: YC
authors.lastname: Pan
authors.forename: Jia-Qin
authors.initials: JQ
authors.lastname: Xu
authors.forename: Su
authors.initials: S
authors.lastname: Yuan
authors.forename: Zun-Hong
authors.initials: ZH
authors.lastname: Liang
authors.forename: Si-Huan
authors.initials: SH
authors.lastname: Chen
authors.forename: Ru-Mei
authors.initials: RM
authors.lastname: Chen
authors.forename: Si-Yan
authors.initials: SY
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D002056:Burns / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D020405:Dermis / Q000637:transplantation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D013995:Time; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D055815:Young Adult