title: [Ultrastructural changes of hepatocyte fibrogenesis in cholelithiasis].
abstract: OBJECTIVE
  To explore the ultrastructural changes of hepatocyte fibrogenesis in cholelithiasis in biliary tract.
  
  
  METHODS
  l0 liver biopsies were taken from the patients suffered from gallstone and choledocholithiasis during surgical treatment and the ultrastructural changes were observed under electromicroscope.
  
  
  RESULTS
  There were plentiful collagenous microfibrils (CMFs) grown within some hepatocytes. These CMFs distributed locally or diffusely in cytoplasm even extended into nucleus. In 7 cases numerous megamitochondrias appeared in several hepatocytes, the inclusions mimicking fibrils could be frequently seen and grew beyond the envelope. Furthermore, typical CMFs could be seen in the large microbodies, and several vesicular or cystic structures similar as fibroblast were presented in marginal areas of the hepatocytes.
  
  
  CONCLUSIONS
  We deduce that the fibrosed hepatocytes may be remained and take part in the hyperplasia of hepatic fibrous tissue.
authors.affiliation: Pathological Department, the 81 Hospital, Nanjing 210002, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ye
authors.forename: Pin
authors.initials: P
authors.lastname: Tu
authors.forename: Gui-mei
authors.initials: GM
authors.lastname: Li
authors.forename: Mei-zhao
authors.initials: MZ
authors.lastname: LE
authors.forename: Mao-hong
authors.initials: MH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002769:Cholelithiasis / Q000473:pathology* / Q000648:ultrastructure*; D005260:Female; D022781:Hepatocytes / Q000473:pathology* / Q000648:ultrastructure*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D008875:Middle Aged