title: A novel replicated association between FXYD6 gene and schizophrenia.
abstract: FXYD6 gene is located in chromosome region 11q22-q24 where previous studies have shown an association with schizophrenia. However, the subsequent studies failed to replicate this finding. To investigate the relationship between FXYD6 locus and schizophrenia in Chinese population, we genotyped six single-nucleotide polymorphisms (SNPs) in this region of FXYD6 in 1142 Han Chinese subjects (576 cases and 566 controls), and performed an association analysis. Significant associations with schizophrenia and the marker rs11544201 (P=0.0028) and the haplotype rs10790212-rs11544201 (global P=0.005) were found. Our results support that FXYD6 is a susceptibility gene of schizophrenia. Replication of larger samples and functional analysis of FXYD6 are needed.
authors.affiliation: Department of Genetics and Molecular Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, PR China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Zhong
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Chuan
authors.initials: C
authors.lastname: Qiu
authors.forename: Han
authors.initials: H
authors.lastname: Yan
authors.forename: Robert K
authors.initials: RK
authors.lastname: Valenzuela
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.forename: Wanhu
authors.initials: W
authors.lastname: Kang
authors.forename: Shemin
authors.initials: S
authors.lastname: Lu
authors.forename: Tingwei
authors.initials: T
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: C531119:FXYD6 protein, human; D007473:Ion Channels