title: Use of continuation or maintenance electroconvulsive therapy in adolescents with severe treatment-resistant depression.
abstract: Retrospective data are presented for 6 adolescents ranging in age from 14 to 17 years, who were diagnosed with severe treatment-resistant major depression (TRD). Subjects were treated with one or more index courses of electroconvulsive therapy (ECT) followed by continuation ECT (C-ECT, up to 6 months of ECT) or maintenance ECT (M-ECT; ECT beyond 6 months) when necessary. Electroconvulsive therapy was continued until remission or until minimal residual symptoms were evident. Pharmacotherapy and psychotherapy were reintroduced during C-ECT or M-ECT. Premorbid functioning was achieved by 5 of 6 cases. Cognitive deficits were not evident. In fact, comparison of pre-ECT and post-ECT neuropsychological functioning revealed a trend toward improved auditory and verbal memory on most of the results. We concluded that C-ECT and M-ECT are useful and safe treatment strategies for selected adolescents with severe treatment-resistant depression, and symptom remission may be achieved without experiencing cognitive impairment.
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, MI. neerag@umich.edu
authors.forename: Neera
authors.initials: N
authors.lastname: Ghaziuddin
authors.forename: Sara
authors.initials: S
authors.lastname: Dumas
authors.forename: Elise
authors.initials: E
authors.lastname: Hodges
mesh_terms: D000293:Adolescent; D003865:Major Depressive Disorder / Q000628:therapy*; D004351:Drug Resistance; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome