title: The mechanism of Sandmeyer's cyclization reaction by electrospray ionization mass spectrometry.
abstract: Using electrospray ionization (tandem) mass spectrometry (ESI-MS(/MS)) spectrometric experiments, the Sandmeyer reaction was monitored on-line, and key intermediates were intercepted and characterized for the first time. The mechanistic information provided by on-line ESI-MS(/MS) is in accordance with Sandmeyer's proposal, and was made possible by coupling a microreactor on-line to the ESI ion source, which allowed reactions to be screened from 0.7-2.0 s, identifying and characterizing all intermediates that were formed and consumed during the reaction.
authors.affiliation: Instituto de Química-CT, Bloco A, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21941-970, Rio de Janeiro, RJ, Brazil.
authors.forename: Bárbara V
authors.initials: BV
authors.lastname: Silva
authors.forename: Flávio A
authors.initials: FA
authors.lastname: Violante
authors.forename: Angelo C
authors.initials: AC
authors.lastname: Pinto
authors.forename: Leonardo S
authors.initials: LS
authors.lastname: Santos
mesh_terms: D000083:Acetanilides / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008956:Models, Chemical; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry
chemical_list: D000083:Acetanilides; D006571:Heterocyclic Compounds