title: Mastering a mediator: blockade of CCN-2 shows early promise in human diabetic kidney disease.
abstract: In diabetes complications, CCN-2 (known originally as CTGF) has been implicated in diabetic nephropathy both as a marker and a mediator of disease. This commentary addresses CCN-2 in diabetic nephropathy, in the context of the recent publication of the first human study to inhibit CCN-2 bioactivity in diabetic kidney disease.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Twigg