title: Neuroprotective effects of immobilized granulocyte colony-stimulating factor and hyaluronidase.
abstract: Neuroprotective activity of immobilized granulocyte CSF (nanotechnology with electron-beam synthesis) and hyaluronidase was studied on the model of posthypoxic encephalopathy. Oral administration of immobilized granulocyte CSF had no effect on manifestations of posthypoxic psychoneurological disorders in animals. Combined treatment with immobilized granulocyte CSF and hyaluronidase prevented impairment of orientation and exploratory behavior and development of amnesia in mice with hypoxic injury.
authors.affiliation: Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Andreeva
authors.forename: E I
authors.initials: EI
authors.lastname: Vereshagin
authors.forename: N N
authors.initials: NN
authors.lastname: Ermakova
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: O V
authors.initials: OV
authors.lastname: Pershina
authors.forename: E G
authors.initials: EG
authors.lastname: Skurikhin
authors.forename: G N
authors.initials: GN
authors.lastname: Zjuzkov
authors.forename: M Ju
authors.initials: MJ
authors.lastname: Minakova
authors.forename: E S
authors.initials: ES
authors.lastname: Khmelevskaya
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001927:Brain Diseases / Q000188:drug therapy* / Q000209:etiology*; D005106:Exploratory Behavior / Q000187:drug effects; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage / Q000494:pharmacology*; D000860:Hypoxia / Q000150:complications*; D055767:Immobilized Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018696:Neuroprotective Agents / Q000494:pharmacology*
chemical_list: D055767:Immobilized Proteins; D018696:Neuroprotective Agents; D016179:Granulocyte Colony-Stimulating Factor; D006821:Hyaluronoglucosaminidase