title: Novel pharmacological targets from Indian cone snails.
abstract: The oceans are a source of combinatorial library of unique natural products, 'not found in the terrestrial environment'. Marine invertebrates such as sponges, molluscs, bryozoans, tunicates (Urochordata) and their associated microorganisms are the major representatives of promising bioactive compounds. Among these, the predatory molluscan cone snails have evolved with highly structured small and complex array of peptides (more than 50,000) linked to their prey capture and defence. These peptides have become a valuable source of neuro pharmacological targets as many of them selectively modulate ion channels and transporters. A group of scientists from United States, Europe, Australia, Israel and China have been characterized drugs for neuropathic pain and pharmacological targets from the peptides of a few cone snail species. Several are now in Clinical and preclinical development. Less than 1% of the cono peptides are pharmacologically characterized. India has a diversity of 20-30% of total cone snail species distributed worldwide. A group of Indian Scientists have made promising drug discovery programs from Conus peptides. This review will focus on the Conus peptides from Indian cone snails species, their neuro pharmacological targets and future directions.
authors.affiliation: Asthagiri Herbal Research Foundation, 162 A, Second Floor, Perungudi Industrial Estate, Perungudi, Chennai-600096, Tamil Nadu, India. ramasamy.mani@gmail.com
authors.forename: M Santhana
authors.initials: MS
authors.lastname: Ramasamy
authors.forename: S
authors.initials: S
authors.lastname: Manikandan
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects; D052078:Conus Snail / Q000737:chemistry*; D055808:Drug Discovery; D006801:Humans; D007194:India; D007473:Ion Channels / Q000187:drug effects; D008978:Mollusk Venoms / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects
chemical_list: D001688:Biological Products; D015220:Calcium Channels; D007473:Ion Channels; D008978:Mollusk Venoms; D010455:Peptides; D015222:Sodium Channels