title: Depression and epilepsy: A bidirectional relation?
abstract: A bidirectional relation between depressive disorders and epilepsy has been suggested by several population-based studies and is supported by experimental studies. This article reviews the potential pathogenic mechanisms operant in both disorders that may explain such a relation. These mechanisms include a hyperactive hypothalamic-pituitary-adrenal (HPA) axis and its neuroanatomic and neuropathologic complications, as well as disturbances in serotonergic, noradrenergic, γ-aminobutyric acid (GABA)ergic and glutamatergic neurotransmitter systems, all of which may be interrelated.
authors.affiliation: Department of Neurological Sciences, Rush Medical College at Rush University, Rush University Medical Center, Chicago, Illinois 60612, USA. akanner@rush.edu
authors.forename: Andres M
authors.initials: AM
authors.lastname: Kanner
mesh_terms: D000818:Animals; D003866:Depressive Disorder / Q000209:etiology* / Q000473:pathology / Q000523:psychology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000150:complications* / Q000473:pathology / Q000523:psychology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D001523:Mental Disorders / Q000150:complications / Q000523:psychology; D010913:Pituitary-Adrenal System / Q000503:physiopathology