title: Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain.
abstract: Several components in the Wnt pathway, including β-catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 (TCF7L2) and v-myc myelocytomatosis viral oncogene homolog (MYC), were increased in Alzheimer's disease (AD) (P < .05). Furthermore, no clear differences in TCF7L2 and MYC mRNA were found in brains with frontotemporal lobar degeneration, suggesting that altered regulation of these Wnt-related genes could be specific to AD. Finally, mRNA levels of three neurogenesis markers were analyzed. Increased mRNA levels of dihydropyrimidinase-like 3 were observed in AD brain, suggesting that altered Wnt pathway regulation may signify synaptic rearrangement or neurogenesis.
authors.affiliation: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85 Uppsala, Sweden.
authors.forename: Elin S
authors.initials: ES
authors.lastname: Blom
authors.forename: Yijing
authors.initials: Y
authors.lastname: Wang
authors.forename: Lena
authors.initials: L
authors.lastname: Skoglund
authors.forename: Anita C
authors.initials: AC
authors.lastname: Hansson
authors.forename: Massimo
authors.initials: M
authors.lastname: Ubaldi
authors.forename: Anbarasu
authors.initials: A
authors.lastname: Lourdusamy
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Sommer
authors.forename: Matthew
authors.initials: M
authors.lastname: Mielke
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.forename: Markus
authors.initials: M
authors.lastname: Heilig
authors.forename: Lars
authors.initials: L
authors.lastname: Lannfelt
authors.forename: Lars N G
authors.initials: LN
authors.lastname: Nilsson
authors.forename: Martin
authors.initials: M
authors.lastname: Ingelsson