title: Hepatic apolipoprotein B biogenesis: an update.
abstract: Approximately one half to two thirds of newly synthesized apolipoprotein B (apoB) in Hep G2 cells (a human hepatoma cell line) is degraded. The intracellular degradation of apoB associated with the rough endoplasmic reticulum (ER) is reviewed in the context of our current understanding of proteasome-mediated degradation of ER-associated proteins. A model of hepatic apoB biogenesis is presented.
authors.affiliation: Departments of Cell Biology and Medicine, Baylor College of Medicine, Texas Medical Center, Houston, Texas, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: Sai-Ching
authors.forename: L
authors.initials: L
authors.lastname: Chan