title: Non-red blood cell transfusion as a risk factor for mortality following percutaneous coronary intervention.
abstract: BACKGROUND
  Bleeding following percutaneous coronary intervention (PCI) is common and may lead to transfusion and death. Although previous work has examined the effect of red blood cell (RBC) transfusion in patients with coronary disease, no study had investigated whether transfusion of non-RBC components was associated with mortality following PCI.
  
  
  METHODS
  All subjects transfused in the 10 days following PCI were identified using the British Columbia Cardiac and Central Transfusion Registries. Patients undergoing cardiac surgery following PCI were excluded as transfusion was assumed to be due to surgical related bleeding. Transfusion products were categorised as RBC and non-RBC comprising platelets, plasma and cryoprecipitate. Blood product use was compared according to thirty day mortality using multivariate regression and propensity adjustment for confounding variables.
  
  
  RESULTS
  From a total of 32,580 patients who underwent PCI, 952 patients received at least 1 blood product within 10 days of PCI. Non-RBC transfusion occurred more commonly in the cohort of transfused patients dying within 30 days (p<0.001). After adjustment for baseline risk, transfusion of plasma/cryoprecipitate (HR 5.17; 95% C.I. 2.87-9.32, p<0.001) and platelets (HR 2.13; 95% C.I. 1.10-4.13, p=0.03) was associated with increased 30 day mortality. In a propensity risk adjusted model, transfusion of plasma/cryoprecipitate and RBC transfusion volume remained as significant predictors of 30-day mortality (p<0.001).
  
  
  CONCLUSIONS
  Transfusion following PCI appears to be associated with an increased risk of death within 30 days. We now report that transfusion with plasma rich non-RBC products may confer an additional mortality risk to patients undergoing PCI.
authors.affiliation: Victoria Heart Institute Foundation, Victoria BC, Canada. sdrobinson@vhif.org
authors.forename: Simon D
authors.initials: SD
authors.lastname: Robinson
authors.forename: Christian
authors.initials: C
authors.lastname: Janssen
authors.forename: Eric B
authors.initials: EB
authors.lastname: Fretz
authors.forename: Alex J
authors.initials: AJ
authors.lastname: Chase
authors.forename: Anthony Della
authors.initials: AD
authors.lastname: Siega
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Carere
authors.forename: Anthony
authors.initials: A
authors.lastname: Fung
authors.forename: Gerald
authors.initials: G
authors.lastname: Simkus
authors.forename: J David
authors.initials: JD
authors.lastname: Hilton
authors.forename: Brian
authors.initials: B
authors.lastname: Berry
authors.forename: W Peter
authors.initials: WP
authors.lastname: Klinke
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000401:mortality*; D000075202:Contraindications; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000401:mortality*; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D017713:Platelet Transfusion / Q000009:adverse effects / Q000401:mortality; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends