title: [Role of chemokines in the development of age-related macular degeneration].
abstract: Age-related macular degeneration (AMD) is the main cause of irreversible blindness in industrialized nations. Recent research has emphasized the importance of inflammatory processes in pathogenesis of this disease. Chemotactic cytokines also named chemokines are important mediators of inflammation and might have a role in development of this disease. They appear to be crucial in the subretinal microglia / macrophage accumulation observed in AMD and may participate in the development of retinal degeneration and in choroidal neovascularization. This paper reviews the possible implication of chemokines in the development of AMD.
authors.affiliation: INSERM, UMR S 872, Centre de Recherche des Cordeliers, 15 rue de l'École de Médcine, 75006 Paris, France.
authors.forename: William
authors.initials: W
authors.lastname: Raoul
authors.forename: Elise
authors.initials: E
authors.lastname: Lelièvre
authors.forename: Constance
authors.initials: C
authors.lastname: Auvynet
authors.forename: Charles
authors.initials: C
authors.lastname: Feumi
authors.forename: Christophe
authors.initials: C
authors.lastname: Combadière
authors.forename: Florian
authors.initials: F
authors.lastname: Sennlaub
mesh_terms: D000818:Animals; D000073883:CX3C Chemokine Receptor 1; D018932:Chemokine CCL2 / Q000502:physiology; D018925:Chemokines / Q000502:physiology*; D006801:Humans; D008268:Macular Degeneration / Q000276:immunology*; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000502:physiology
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D018932:Chemokine CCL2; D018925:Chemokines; D019707:Receptors, Chemokine