title: Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation.
abstract: We tested the effect of oral administration of fermented sake lees with lactic acid bacteria (FESLAB) on a murine model of allergic rhinitis upon immunization and nasal sensitization with ovalbumin (OVA). We used Lactobacillus paracasei NPSRIk-4 (isolated from sake lees), and L. brevis NPSRIv-8 (from fermented milk) as starter strains to produce the FESLAB. Oral FESLAB administration resulted in the development of significantly fewer sneezing symptoms than those seen in sham control animals given sterile water. We also found that FESLAB suppressed the allergen-induced degranulation of RBL2H3 rat basophilic leukemia cells.
authors.affiliation: Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8530, Japan. skawa@hiroshima-u.ac.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawamoto
authors.forename: Mitsuoki
authors.initials: M
authors.lastname: Kaneoke
authors.forename: Kayo
authors.initials: K
authors.lastname: Ohkouchi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Amano
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takaoka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kume
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Aki
authors.forename: Susumu
authors.initials: S
authors.lastname: Yamashita
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Motoni
authors.initials: M
authors.lastname: Kadowaki
authors.forename: Dai
authors.initials: D
authors.lastname: Hirata
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D001491:Basophils / Q000166:cytology* / Q000276:immunology; D015550:Cell Degranulation; D045744:Cell Line, Tumor; D019587:Dietary Supplements; D005260:Female; D005285:Fermentation; D006967:Hypersensitivity / Q000150:complications; D007073:Immunoglobulin E / Q000276:immunology*; D007778:Lactobacillus / Q000378:metabolism*; D051379:Mice; D051381:Rats; D012220:Rhinitis / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D014920:Wine
chemical_list: D007073:Immunoglobulin E