title: [Educational efficacy of computer software showing the effect-site concentration of fentanyl in anesthesia training].
abstract: BACKGROUND
  We investigated the efficacy of computer software showing the effect-site concentration of fentanyl in anesthesia training.
  
  
  METHODS
  All patients were randomly divided into the following three groups. Anesthesia management was performed with a pharmacokinetic simulation program by anesthesia residents with experience in using it for less than 3 months (P (+) group, n = 32). Anesthesia management was performed without a pharmacokinetic simulation program by anesthesia residents with experience in using it for less than two weeks (P (-) group, n = 25). Anesthesia management was performed without a pharmacokinetic simulation program by anesthesia residents with no experience in using it, under supervision of experienced anesthesiologists (C group, n = 22). We measured the effect-site concentration of fentanyl (Ce of fentanyl) at the end of surgery, intraoperative total doses of fentanyl and propofol, the time required from the end of operation to extubation, and frequency of analgesics required within 24 hours.
  
  
  RESULTS
  Total doses of fentanyl were significantly more in P (+) group than in other two groups. Ce of fentanyl were significantly more in P (+) group than in other two groups.
  
  
  CONCLUSIONS
  A pharmacokinetic simulation program is useful for anesthesia residents.
authors.affiliation: Department of Anesthesiology and Reanimatology, University of Fukui Hospital, Eiheiji 910-1193.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Matsuki
authors.forename: Masashi
authors.initials: M
authors.lastname: Ueda
authors.forename: Mari
authors.initials: M
authors.lastname: Tabata
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Nobukawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Shigemi
mesh_terms: D000768:Anesthesia, General; D000776:Anesthesiology / Q000193:education*; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics*; D003198:Computer Simulation; D004503:Education, Medical, Graduate / Q000379:methods*; D005283:Fentanyl / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D007396:Internship and Residency; D012984:Software
chemical_list: D018686:Anesthetics, Intravenous; D005283:Fentanyl