title: On the relevance of automatically selected single-voxel MRS and multimodal MRI and MRSI features for brain tumour differentiation.
abstract: In order to evaluate the relevance of magnetic resonance (MR) features selected by automatic feature selection techniques to build classifiers for differential diagnosis and tissue segmentation two data sets containing MR spectroscopy data from patients with brain tumours were investigated. The automatically selected features were evaluated using literature and clinical experience. It was observed that a significant part of the automatically selected features correspond to what is known from the literature and clinical experience. We conclude that automatic feature selection is a useful tool to obtain relevant and possibly interesting features, but evaluation of the obtained features remains necessary.
authors.affiliation: Institute for Molecules and Materials, Radboud University Nijmegen, Heijendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. g.j.postma@science.ru.nl
authors.forename: Geert J
authors.initials: GJ
authors.lastname: Postma
authors.forename: Jan
authors.initials: J
authors.lastname: Luts
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Idema
authors.forename: Margarida
authors.initials: M
authors.lastname: Julià-Sapé
authors.forename: Angel
authors.initials: A
authors.lastname: Moreno-Torres
authors.forename: Witek
authors.initials: W
authors.lastname: Gajewicz
authors.forename: Johan A K
authors.initials: JA
authors.lastname: Suykens
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Huffel
authors.forename: Lutgarde M C
authors.initials: LM
authors.lastname: Buydens
mesh_terms: D000704:Analysis of Variance; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D019295:Computational Biology / Q000379:methods*; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008579:Meningioma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology; D018709:Statistics, Nonparametric