title: Functional aliphatic polyesters for biomedical and pharmaceutical applications.
abstract: Functional aliphatic polyesters are biodegradable polymers with many possibilities to tune physico-chemical characteristics such as hydrophilicity and degradation rate as compared to traditional polyesters (e.g. PLLA, PLGA and PCL), making the materials suitable for drug delivery or as scaffolds for tissue engineering. Lately, a large number of polyesters have been synthesized by homopolymerization of functionalized monomers or co-polymerization with other monomers mainly via ring-opening polymerization (ROP) of cyclic esters. This review presents the recent trends in the synthesis of these materials and their application for protein delivery and tissue engineering.
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: Hajar
authors.initials: H
authors.lastname: Seyednejad
authors.forename: Amir H
authors.initials: AH
authors.lastname: Ghassemi
authors.forename: Cornelus F
authors.initials: CF
authors.lastname: van Nostrum
authors.forename: Tina
authors.initials: T
authors.lastname: Vermonden
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
mesh_terms: D000818:Animals; D004247:DNA / Q000008:administration & dosage*; D018014:Gene Transfer Techniques; D006801:Humans; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage*; D023822:Tissue Engineering
chemical_list: D011091:Polyesters; D011506:Proteins; D004247:DNA