title: [A case of sigmoid colon cancer with synchronous multiple liver and lung metastases, who survived 25-month after combination of chemotherapy and metastasectomy].
abstract: A 60-year-old male underwent sigmoidectomy for sigmoid colon cancer with synchronous multiple liver and lung metastases. Six weeks after the sigmoidectomy, mFOLFOX6 + bevacizumab (Bmab) was initiated. After 7 courses, lung tumors were almost disappeared and liver tumors shrunken up to 69% in size, and metastasectomy of liver tumors was performed with R0 resection. Pathological examination disclosed that tumor response to chemotherapy was Grade 2. mFOLFOX6 + Bmab, FOLFIRI + Bmab, and cetuximab were administered after liver surgery before the patient died 25 months after the sigmoidectomy. Combination therapy of metastasectomy and intensive chemotherapy might benefit to prolong survival of the patient.
authors.affiliation: Dept. of Colorectal Surgery, Tokyo Medical and Dental University Hospital of Medicine.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Kikuchi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uetake
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Arii
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D000068258:Bevacizumab; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D000068818:Cetuximab; D003082:Colectomy; D012809:Colon, Sigmoid / Q000601:surgery; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012811:Sigmoid Neoplasms / Q000473:pathology* / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000068258:Bevacizumab; D000068818:Cetuximab; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin