title: Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status.
abstract: The cholinergic system arising from the substantia innominata (SI) of the basal forebrain has an important role in the cognitive functions of Parkinson's disease (PD). We performed magnetic resonance imaging based volumetric analysis to evaluate the SI volume in patients with PD-intact cognition (PD-IC), PD-mild cognitive impairment (PD-MCI), and PD dementia (PDD). The mean normalized SI volume was significantly decreased in patients with PD-IC (1.54 ± 0.12, p < 0.001), PD-MCI (1.49 ± 0.12, p < 0.001), and PDD (1.39 ± 0.12, p < 0.001) compared with that of control subjects (1.68 ± 0.11). The normalized SI volume did not differ between patients with PD-IC and PD-MCI; however, the normalized SI volume was significantly decreased in patients with PDD compared with that in those with PD-IC (p < 0.001) or PD-MCI (p = 0.016). The normalized SI volume was significantly correlated with general cognitive status (r = 0.51, p < 0.001) as well as with performance in each cognitive subdomain, with a particularly significant independent association with attention (β = 0.33, p = 0.003) and object naming (β = 0.26, p = 0.017). The present study demonstrated that the SI volume in PD differs depending on cognitive status and is significantly correlated with cognitive performance.
authors.affiliation: Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seo Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Tae Min
authors.initials: TM
authors.lastname: Jung
authors.forename: Ji E
authors.initials: JE
authors.lastname: Lee
authors.forename: Seung-Koo
authors.initials: SK
authors.lastname: Lee
authors.forename: Young H
authors.initials: YH
authors.lastname: Sohn
authors.forename: Phil Hyu
authors.initials: PH
authors.lastname: Lee
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000473:pathology* / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010300:Parkinson Disease / Q000473:pathology* / Q000523:psychology*; D011446:Prospective Studies; D013377:Substantia Innominata / Q000473:pathology*