title: [A case of multiple liver metastases from nonfunctioning neuroendocrine pancreatic tumor curatively resected after successful intra-arterial chemotherapy].
abstract: We report a case of 33-year-old woman for nonfunctioning neuroendocrine pancreatic tumor with synchronous multiple liver metastases. For the primary pancreatic legion, we performed pylorus-preserving pancreatoduodenectomy at first. Three weeks after the surgery, the patient started to undergo intra-arterial chemotherapy with a weekly administration of high-dose 5-FU (1,000 mg/body) for residual liver metastases. Any severe adverse events were not observed. After 20 courses, a partial response was achieved and she underwent curative operation with partial resection for 4 metastatic legions and RFA for others. Histopathological findings of resected specimens revealed no viable neoplastic tissues. She is alive with no sign of recurrence 3 months after the surgery. Although a surgical resection is accepted as the standard therapy for liver metastases of nonfunctioning neuroendocrine pancreatic tumor, intra-arterial chemotherapy might be an alternative therapeutic option for unresectable case.
authors.affiliation: Dept. of Hepato-Gastrointestinal Surgery, Odawara Municipal Hospital.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kametaka
authors.forename: Hironobu
authors.initials: H
authors.lastname: Makino
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Seike
authors.forename: Akio
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary*; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000628:therapy*; D016577:Pancreaticoduodenectomy
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil