title: [Using the combination of traditional risk factors and quantitative coronary angiography (QCA) in predicting the risk of individuals with subclinical artherosclerosis].
abstract: OBJECTIVE
  To determine whether the combination of traditional risk factors and quantitative coronary angiography (QCA) assessment could provide accurate prognostic information on a population-based study including 1137 adults with subclinical artherosclerosis and with coronary risk factors.
  
  
  METHODS
  Participants underwent coronary angiography examination before the minimal stenotic diameters, segment diameters, percent stenosis, plaque areas. Other parameters were analyzed by the computer-assisted Coronary Angiography Analysis System. The Framingham Risk Score for each participant was assessed. During the 1 year follow-up period, all kinds of endpoint cardiovascular events were screened. Endpoint events were defined as death from coronary heart disease, nonfatal myocardial infarction (MI) or unstable angina pectoris.
  
  
  RESULTS
  During the 1 year of follow-up period, a total of 124 participants developed an endpoint event, which was significantly associated with the Framingham Risk Score, calcium of plaques and the plaque areas (all Ps<0.05). The QCA score incorporated with the QCA parameters was related to the endpoint events. The Framingham Risk Score was combined with QCA score through logistic regression for prediction of end-point events. Data from the ROC analysis showed the accuracy of this prediction algorithm was superior to the accuracy when variables themselves were used. The event-free survival rate was inferior to the control group in participates under high risk, when being screened with this prediction algorithm (P<0.05).
  
  
  CONCLUSIONS
  The risk of cardiovascular attack in subclinical artherosclerosis individual seemed to be associated with the Framingham Risk Score, calcium of plaques and the plaque areas. When the traditional risk factors (the Framingham Risk Score) were combined with QCA, the new method could provide more prognostic information on those adults with subclinical artherosclerosis.
authors.affiliation: Department of Cardiology of Beijing Anzhen Hospital, Capital Medicine University, Beijing 100029, China.
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Wang
authors.forename: Shu-zheng
authors.initials: SZ
authors.lastname: Lv
authors.forename: Jing-hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Yun-dai
authors.initials: YD
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Li
authors.forename: Yuan-nan
authors.initials: YN
authors.lastname: Ke
authors.forename: Xin-chun
authors.initials: XC
authors.lastname: Yang
authors.forename: Shu-yang
authors.initials: SY
authors.lastname: Zhang
authors.forename: Hong-bing
authors.initials: HB
authors.lastname: Yan
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Li
authors.forename: Da-zhuo
authors.initials: DZ
authors.lastname: Shi
authors.forename: Bu-xing
authors.initials: BX
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult