title: [Pharmacokinetics and bioavailability of sustained-release tablets of matrine in dogs].
abstract: OBJECTIVE
  To study the pharmacokinetics and bioavailability of sustained-release tablets of Matrine in dogs.
  
  
  METHODS
  6 dogs were randomly assigned to receive sustained-release tablets or commercial capsules 300 mg, then a crossover trial was conducted 1 week later. Plasma samples were taken at different time points and the plasma concentration of Oxymatrine and Matrine in dogs was determined by HPLC.
  
  
  RESULTS
  The pharmacokinetic parameters of self-made sustained-release tablets versus those of its control preparation were as follows: Tmax: (6.17 +/- 2.04) (M), (3.25 +/- 0.61) (OM), (4.75 +/- 1.17) (M), (2.42 +/- 0.38) (OM) h; Cmax: (3.79 +/- 1.11) (M), (4.76 +/- 0.60) (OM), (5.35 +/- 0.72) (M), (7.04 +/- 0.47) (OM) microg/mL; AUC(0-->infinity): (45.15 +/- 11.77) (M), (32.38 +/- 4.60) (OM) and (44.71 +/- 5.52) (M), (29.11 +/- 4.41) (OM) microg x h/mL.
  
  
  CONCLUSIONS
  The self-made sustained-release tablets and commercial capsules bioequivalent.
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. zwei.Lee@163.com
authors.forename: Zong-wei
authors.initials: ZW
authors.lastname: Li
authors.forename: Guo-feng
authors.initials: GF
authors.lastname: Li
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000470:Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002214:Capsules / Q000008:administration & dosage / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011807:Quinolizines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets / Q000008:administration & dosage / Q000493:pharmacokinetics; D013810:Therapeutic Equivalency; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D011807:Quinolizines; D013607:Tablets; C037573:oxymatrine; D000093842:Matrines