title: Serum pigment epithelium-derived factor is elevated in women with polycystic ovary syndrome and correlates with insulin resistance.
abstract: BACKGROUND
  Serum pigment epithelium-derived factor (PEDF) is highly expressed in adipose tissue and plays an important role in insulin resistance (IR). However, there are no data on serum PEDF levels and their relationship with IR in polycystic ovary syndrome (PCOS) women.
  
  
  OBJECTIVE
  To quantitate serum PEDF levels and examine their relationship with IR in women with PCOS.
  
  
  METHODS
  Ninety-six PCOS women and 63 healthy age-matched controls were recruited. Ninety-six PCOS women and 20 controls underwent hyperinsulinemic-euglycemic clamp to assess their insulin sensitivity, which was expressed as M value. IR was also estimated by homeostasis model assessment 2 (HOMA2-IR).
  
  
  METHODS
  The study was performed at a clinical research center.
  
  
  RESULTS
  PCOS women had lower M value and higher HOMA2-IR as compared with controls. Serum PEDF levels were much higher in PCOS women than in controls (5.45 ± 1.85 vs. 3.97 ± 0.98 μg/ml, P < 0.01). Spearman correlation analysis showed that in PCOS women, PEDF positively correlated with body mass index, waist circumference, HOMA2-IR, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and systolic blood pressure and negatively correlated with M value and high-density lipoprotein cholesterol. Multiple linear regression analysis revealed that in PCOS women, after adjustment for body mass index, systolic blood pressure, and serum lipids (triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol), PEDF was still associated with M value or HOMA2-IR.
  
  
  CONCLUSIONS
  The serum PEDF level is elevated in women with PCOS and is associated with IR. PEDF may play a role in the pathogenesis of IR in PCOS.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Street, Chongqing 400016, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Yang
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
authors.forename: Ying
authors.initials: Y
authors.lastname: Song
authors.forename: Bo
authors.initials: B
authors.lastname: Tian
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Cheng
authors.forename: Hua
authors.initials: H
authors.lastname: Qing
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.forename: Mei
authors.initials: M
authors.lastname: Luo
authors.forename: Mei
authors.initials: M
authors.lastname: Mei
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D015999:Multivariate Analysis; D009414:Nerve Growth Factors / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications / Q000175:diagnosis; D050177:Overweight / Q000097:blood / Q000150:complications / Q000175:diagnosis; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D015843:Serpins / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005136:Eye Proteins; D007328:Insulin; D009414:Nerve Growth Factors; D015843:Serpins; D014280:Triglycerides; D000099174:Pigment Epithelium-Derived Factor