title: Structure-activity relationships (SAR) of melanocortin and agouti-related (AGRP) peptides.
abstract: Structure-activity relationship (SAR) studies are a key feature of peptide and peptidomimetic research to improve the biological properties of native peptides and convert them into more drug-like compounds. Peptide SAR studies involve the systematic modification of a lead peptide to provide insight into the molecular determinants of the ligand-receptor interactions that result in either receptor stimulation or inhibition. This chapter will discuss structure-activity relationships of the endogenous and synthetic agonists and the antagonists of the melanocortin system.
authors.affiliation: Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610-0487, USA.
authors.forename: Anamika
authors.initials: A
authors.lastname: Singh
authors.forename: Erica M
authors.initials: EM
authors.lastname: Haslach
authors.forename: Carrie
authors.initials: C
authors.lastname: Haskell-Luevano
mesh_terms: D054369:Agouti-Related Protein / Q000737:chemistry* / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D055808:Drug Discovery; D006801:Humans; D053486:Melanocortins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D054369:Agouti-Related Protein; D053486:Melanocortins; D010446:Peptide Fragments; C412618:agouti-related peptide, (Yc(CRFFNAFC)Y)