Epigenetic targets of bioactive dietary components for cancer prevention and therapy.
The emergent interest in cancer epigenetics stems from the fact that epigenetic modifications are implicated in virtually every step of tumorigenesis. More interestingly, epigenetic changes are reversible heritable changes that are not due to the alteration in DNA sequence but have potential to alter gene expression. Dietary agents consist of many bioactive ingredients which actively regulate various molecular targets involved in tumorigenesis. We present evidence that numerous bioactive dietary components can interfere with various epigenetic targets in cancer prevention and therapy. These agents include curcumin (turmeric), genistein (soybean), tea polyphenols (green tea), resveratrol (grapes), and sulforaphane (cruciferous vegetables). These bioactive components alter the DNA methylation and histone modifications required for gene activation or silencing in cancer prevention and therapy. Bioactive components mediate epigenetic modifications associated with the induction of tumor suppressor genes such as p21(WAF1/CIP1) and inhibition of tumor promoting genes such as the human telomerase reverse transcriptase during tumorigenesis processes. Here, we present considerable evidence that bioactive components and their epigenetic targets are associated with cancer prevention and therapy which should facilitate novel drug discovery and development. In addition, remarkable advances in our understanding of basic epigenetic mechanisms as well as the rapid progress that is being made in developing powerful new technologies, such as those for sensitive and quantitative detection of epigenetic and epigenomic changes in cancer biology, hold great promise for novel epigenetic approaches to cancer prevention and therapy.
Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard, Campbell Hall 175, Birmingham, AL 35294-1170, USA.
Syed M
SM
Meeran
Amiya
A
Ahmed
Trygve O
TO
Tollefsbol
Mutagenesis. 2007 Mar;22(2):91-103
17284773
J Clin Invest. 2008 Mar;118(3):868-78
18292809
Int J Cancer. 2009 Jun 1;124(11):2677-82
19170207
J Nutr. 2005 Aug;135(8):1865-72
16046710
Cell. 2007 Feb 23;128(4):693-705
17320507
Br J Cancer. 2008 Aug 19;99(4):647-54
18665171
Bioorg Med Chem. 2010 Feb;18(3):1252-8
20045338
Crit Rev Food Sci Nutr. 2009 Oct;49(9):782-99
20443159
Cancer Prev Res (Phila). 2009 May;2(5):409-18
19401532
Cell Cycle. 2006 Oct;5(19):2220-2
17012846
Anticancer Res. 2009 Jun;29(6):2025-30
19528461
BMC Cancer. 2010 May 26;10:238
20504360
Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23
18421014
Endocrinology. 2008 Dec;149(12):5922-31
18669593
Eur J Biochem. 2001 Jan;268(1):1-6
11121095
Pharmacol Res. 2007 Mar;55(3):224-36
17317210
Biochim Biophys Acta. 2007 Jan;1775(1):76-91
16930846
BMC Physiol. 2008 Sep 15;8:17
18793434
J Nutr. 1995 Mar;125(3 Suppl):777S-783S
7884564
Am J Pathol. 2003 Oct;163(4):1371-8
14507645
Nat Genet. 2005 Apr;37(4):391-400
15765097
Int J Mol Med. 2010 Aug;26(2):209-15
20596600
Acta Pharmacol Sin. 2005 May;26(5):603-9
15842781
Annu Rev Nutr. 2001;21:381-406
11375442
Carcinogenesis. 2006 Apr;27(4):811-9
16280330
Br J Pharmacol. 2008 Mar;153(6):1225-31
18204486
APMIS. 2007 Oct;115(10):1039-59
18042143
J Biochem Mol Biol. 2003 Jan 31;36(1):110-9
12542981
Nat Rev Drug Discov. 2006 Sep;5(9):769-84
16955068
Clin Cancer Res. 2005 May 15;11(10):3604-8
15897554
Semin Cancer Biol. 2007 Oct;17(5):363-9
17555985
Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51
17416783
Oncol Res. 2008;17(5):223-30
18980019
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004
14973191
Cancer Epidemiol. 2010 Jun;34(3):350-4
20362526
Cancer Res. 2009 Jan 15;69(2):583-92
19147572
Oncol Rep. 2009 Sep;22(3):563-7
19639204
Photochem Photobiol. 2009 May-Jun;85(3):652-62
19076306
Med Chem. 2006 Mar;2(2):169-74
16787365
Carcinogenesis. 2007 Jul;28(7):1485-90
17347138
Carcinogenesis. 2010 Mar;31(3):496-503
20015867
Eur J Gynaecol Oncol. 2009;30(6):616-21
20099489
Pharm Res. 2009 Oct;26(10):2324-31
19669099
Carcinogenesis. 2006 Feb;27(2):269-77
16081510
Anticancer Res. 2003 Jan-Feb;23(1A):363-98
12680238
Nutr Rev. 2008 Aug;66 Suppl 1:S36-8
18673487
Biochem Pharmacol. 2008 Dec 1;76(11):1340-51
18755156
Bioessays. 2001 Dec;23(12):1131-7
11746232
BMC Cancer. 2010 Jun 10;10:276
20537126
Mutat Res. 2008 Mar-Apr;658(3):191-214
18403253
N Engl J Med. 2008 Mar 13;358(11):1148-59
18337604
Biochem Pharmacol. 2006 May 14;71(10):1397-421
16563357
Oncol Rep. 2010 Aug;24(2):563-9
20596647
Curr Opin Genet Dev. 1993 Apr;3(2):226-31
8504247
J Nutr. 2010 Sep;140(9):1607-14
20631324
Nutrition. 2009 Sep;25(9):964-72
19268536
Toxicol Lett. 2010 Feb 1;192(2):119-25
19840838
Pharm Res. 2008 Feb;25(2):387-99
17657594
Epigenetics. 2008 May-Jun;3(3):164-71
18487953
Mol Nutr Food Res. 2010 Nov;54(11):1574-84
20521268
Cancer Prev Res (Phila). 2009 Nov;2(11):931-41
19892663
FASEB J. 2010 May;24(5):1442-53
20019239
J Natl Cancer Inst. 1997 Dec 17;89(24):1881-6
9414176
J Biol Chem. 2004 Dec 3;279(49):51163-71
15383533
Arch Biochem Biophys. 2009 Jun 15;486(2):95-102
19514131
Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R65-76
15809275
AAPS J. 2010 Mar;12(1):87-97
20013083
Environ Mol Mutagen. 2009 Apr;50(3):213-21
19197985
Mol Pharmacol. 2005 Oct;68(4):917-32
15955865
Prev Med. 1992 May;21(3):334-50
1614995
Carcinogenesis. 2010 Jan;31(1):27-36
19752007
Biochem Pharmacol. 2005 Jan 15;69(2):307-18
15627483
Cancer Res. 2009 Aug 15;69(16):6704-12
19654291
Mol Cancer Ther. 2007 May;6(5):1673-81
17513615
Urology. 2004 Aug;64(2):389-93
15302513
Eukaryot Cell. 2007 Jul;6(7):1219-27
17449656
Basic Clin Pharmacol Toxicol. 2007 Dec;101(6):427-33
17927689
Mol Cancer Ther. 2009 Jun;8(6):1409-20
19509247
Cancer Res. 2006 Feb 1;66(3):1851-8
16452247
Int J Cancer. 2001 Jun 15;92(6):784-9
11351296
J Cell Biochem. 2008 Oct 1;105(2):514-23
18636546
Br J Nutr. 2010 Jun;103(12):1771-7
20175943
Clin Cancer Res. 2009 May 1;15(9):3177-83
19383817
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15805-10
17890317
World J Gastroenterol. 2005 Nov 7;11(41):6512-7
16425425
Carcinogenesis. 2005 Nov;26(11):1879-89
15958520
Biochem Biophys Res Commun. 2004 Dec 17;325(3):1037-43
15541393
Int J Cancer. 2009 Jul 15;125(2):286-96
19358274
J Biol Chem. 2005 Apr 29;280(17):17038-45
15684413
Front Biosci. 2008 Jan 01;13:2191-202
17981702
Eur J Pharmacol. 2010 Jul 25;638(1-3):47-53
20447390
J Clin Invest. 2008 Mar;118(3):879-93
18292803
Oral Oncol. 2009 Nov;45(11):998-1004
19589718
JAMA. 1998 Nov 11;280(18):1569-75
9820257
Mol Cancer Ther. 2007 Nov;6(11):3071-9
18025290
PLoS One. 2008 Mar 12;3(3):e1759
18335035
Carcinogenesis. 2003 Dec;24(12):1903-11
12949046
J Nutr. 2007 Jan;137(1 Suppl):223S-228S
17182830
Mol Cancer. 2010 Mar 02;9:47
20196847
Cancer Prev Res (Phila). 2008 Sep;1(4):219-22
19138962
Pharm Res. 2010 Jun;27(6):1103-14
20232120
Environ Mol Mutagen. 2008 Jan;49(1):36-45
18181168
Cancer Res. 2007 May 1;67(9):4303-10
17483343
Cancer Res. 2008 Apr 15;68(8):2736-44
18413741
Curr Cancer Drug Targets. 2009 Dec;9(8):963-81
20025605
Toxicol Appl Pharmacol. 2010 Jun 15;245(3):378-93
20381512
Int J Oncol. 2010 Jul;37(1):111-23
20514403
Int J Cancer. 2008 Aug 1;123(3):552-60
18431742
Curr Med Chem. 2010;17(20):2141-51
20423306
J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):245-52
17566917
Am J Clin Nutr. 2000 Jun;71(6 Suppl):1698S-702S; discussion 1703S-4S
10837321
Carcinogenesis. 2004 Jul;25(7):1227-36
14976134
Mol Cell. 2008 Oct 10;32(1):11-20
18851829
Curr Probl Cancer. 2007 Jul-Aug;31(4):243-305
17645940
Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):7033-41
16203797
Neoplasia. 2003 Nov-Dec;5(6):555-65
14965448
J Cell Sci. 2005 Dec 15;118(Pt 24):5825-34
16317046
Cancer Res. 2003 Nov 15;63(22):7563-70
14633667
Oncogene. 2009 Aug 13;28(32):2882-93
19503100
Mol Cancer Ther. 2007 Mar;6(3):1013-21
17339367
Nutr Rev. 2007 Feb;65(2):88-94
17345961
Nutr Cancer. 2009;61(2):238-44
19235040
Oncol Rep. 2009 Mar;21(3):635-40
19212621
Cancer Prev Res (Phila). 2009 Dec;2(12):1065-75
19934341
Mol Carcinog. 2006 Jun;45(6):443-6
16652377
Clin Cancer Res. 2004 Jul 15;10(14):4865-73
15269163
EMBO J. 1988 May;7(5):1395-402
3409869
Mol Pharmacol. 2005 Oct;68(4):1018-30
16037419
Exp Biol Med (Maywood). 2007 Feb;232(2):227-34
17259330
J Mammary Gland Biol Neoplasia. 2010 Mar;15(1):19-33
20131086
Gynecol Oncol. 2004 Sep;94(3):760-8
15350370
Clin Exp Metastasis. 2008;25(2):183-9
18058245
FASEB J. 2006 Mar;20(3):506-8
16407454
Cancer Res. 2004 Aug 15;64(16):5767-74
15313918
Nature. 2007 May 24;447(7143):396-8
17522671
Nat Rev Genet. 2009 Oct;10(10):704-14
19763153
Hum Mol Genet. 2000 Oct;9(16):2395-402
11005794
J Nutr. 2002 Aug;132(8 Suppl):2419S-2423S
12163704
J Nutr Biochem. 2011 May;22(5):450-8
20655188
Prostate. 2009 Feb 1;69(2):181-90
18973173
Carcinogenesis. 2005 Jan;26(1):193-200
15498792
Carcinogenesis. 2009 Apr;30(4):662-70
19221000
Semin Reprod Med. 2009 Sep;27(5):380-90
19711248
Nat Rev Genet. 2007 Apr;8(4):286-98
17339880
J Clin Oncol. 2009 Aug 10;27(23):3808-14
19470922
Am J Obstet Gynecol. 2010 Mar;202(3):289.e1-9
20074693
J Nutr. 2009 Dec;139(12):2393-6
19812222
Mol Cancer. 2006 Nov 08;5:60
17092350
Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S196-204
20461740
Mol Carcinog. 2009 Oct;48(10):920-33
19378291
Biol Rev Camb Philos Soc. 1990 Nov;65(4):431-71
2265224
Int J Cancer. 2010 Jun 1;126(11):2520-33
19856314
Stem Cells Dev. 2006 Apr;15(2):165-74
16646663
Proc Natl Sci Counc Repub China B. 2000 Jan;24(1):1-13
10786933
Anticancer Res. 2009 Jun;29(6):2301-5
19528495
Cancer. 2010 Oct 15;116(20):4670-6
20597137
Int J Biochem Cell Biol. 2009 Jan;41(1):87-95
18834952
Nature. 2005 Jun 30;435(7046):1262-6
15988529
Exp Biol Med (Maywood). 2009 Mar;234(3):287-95
19144873
PLoS One. 2010 Jul 06;5(7):e11457
20625516
J Cell Biochem. 2008 Feb 1;103(2):509-19
17570133