Is insulin-dependent diabetes mellitus an autoimmune disorder?
Current evidence suggests that insulin-dependent diabetes mellitus (IDDM) is most likely a slowly progressive autoimmune disorder. More than 90% of Caucasian IDDM patients have DR3 and/or DR4, the HLA region linked to immune response. At onset of disease, most IDDM patients have islet-cell antibodies, more immune-associated T lymphocytes and anti-insulin antibodies. Most IDDM patients who died within six months of diagnosis had insulitis: an infiltration of mononuclear cells (mostly activated T cells) around the pancreatic islets. Immunosuppression therapy may be effective in inducing remission in newly diagnosed IDDM patients.
M H
MH
Tan
R
R
McManus
Diabetes. 1980 Apr;29(4):317-22
6987122
N Engl J Med. 1986 May 22;314(21):1360-8
3517648
Diabetologia. 1978 Mar;14(3):199-207
350681
Lancet. 1975 May 3;1(7914):997-1000
48725
N Engl J Med. 1985 Aug 22;313(8):461-4
3894969
Diabetes. 1977 Feb;26(2):138-47
320073
Diabetes. 1986 Jun;35(6):634-41
3519320
Science. 1976 Apr 2;192(4234):64-6
769160
Lancet. 1985 Mar 16;1(8429):599-602
2857945
Lancet. 1986 Sep 6;2(8506):567
2875293
Lancet. 1984 Jul 7;2(8393):4-6
6145952
N Engl J Med. 1983 Feb 10;308(6):322-5
6337325
Science. 1983 Nov 18;222(4625):727-33
6356354
N Engl J Med. 1978 Nov 23;299(21):1191
212679
J Clin Endocrinol Metab. 1983 Dec;57(6):1301-4
6355141
Science. 1983 Feb 25;219(4587):975-7
6823559
J Clin Endocrinol Metab. 1984 Aug;59(2):187-90
6610685
Lancet. 1985 Jan 12;1(8420):67-71
2857024
Diabetes. 1985 Sep;34(9):926-30
3896901
Diabetes Care. 1979 Mar-Apr;2(2):209-14
520125
Lancet. 1986 Jul 19;2(8499):119-24
2873396
Australas Ann Med. 1967 Aug;16(3):226-9
4861883
J Clin Invest. 1977 Nov;60(5):989-98
908763
Jikken Dobutsu. 1985 Oct;34(4):425-31
3910444
N Engl J Med. 1982 Apr 1;306(13):785-8
7038489
Science. 1983 Dec 23;222(4630):1337-9
6362005
Diabetes. 1983 Apr;32(4):326-30
6832488
Diabetologia. 1981 Jul;21(1):41-6
7024027
Diabetes. 1985 Aug;34 Suppl 3:5-12
3926569
Clin Endocrinol Metab. 1982 Jul;11(2):389-408
6754162
Diabetes. 1986 Aug;35(8):894-8
3525287
Lancet. 1976 Dec 11;2(7998):1273-6
63747
Diabetes. 1986 Feb;35(2):139-42
3510920