Helicoid end-to-side and oblique attachment technique in repair of the musculocutaneous nerve injury with the phrenic nerve as a donor: an experimental study in rats.
The purpose of this study was to identify if a modified end-to-side repair can achieve equal results of nerve regeneration compared to an end-to-end repair using donor phrenic nerves in repair of the musculocutaneous nerve and also pulmonary protection. Eighteen rats were divided into three groups of six each comparing two nerve graft techniques: helicoid end-to-side plus distal oblique repair vs. traditional end-to-end repair, using a donor phrenic nerve. The saphenous nerve was used as a graft between the phrenic nerve and the musculocutaneous nerve. The third group was used as control; the musculocutaneous nerve was transected without any repair. Three months postoperatively, electrophysiology, tetanic force, moist muscle weight, histology, nerve fiber counting, and chest X-ray were evaluated. All results have shown that this modified end-to-side repair was superior to the end-to-end repair. The former did not compromise the diaphragm function, but the latter showed an elevation of the diaphragm. Little recovery was seen in the third group. The conclusion is that this modified end-to-side repair can replace the traditional end-to-end repair using donor phrenic nerves with better results of nerve regeneration without diaphragm compromise.
Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Yu-Hui
YH
Yan
Ji-Geng
JG
Yan
Hani S
HS
Matloub
Lin-Ling
LL
Zhang
Patrick
P
Hettinger
James
J
Sanger
Safwan S
SS
Jaradeh
D000818:Animals; D003964:Diaphragm / Q000000981:diagnostic imaging / Q000502:physiology; D004568:Electrodiagnosis; D005267:Femoral Nerve / Q000637:transplantation*; D007537:Isometric Contraction; D008297:Male; D008866:Microsurgery / Q000379:methods*; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology; D009138:Musculocutaneous Nerve / Q000033:anatomy & histology / Q000293:injuries* / Q000502:physiology / Q000601:surgery*; D009416:Nerve Regeneration; D016067:Nerve Transfer / Q000379:methods*; D010791:Phrenic Nerve / Q000637:transplantation*; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome