Differences in lipoprotein particle subclass distribution for Japanese Americans in Hawaii and Japanese in Japan: the INTERLIPID study.
BACKGROUND
Current data suggest that low density lipoprotein (LDL) and high density lipoprotein (HDL) subclass concentrations relate directly to the risk of coronary heart disease (CHD). Earlier Studies indicated that Japanese in Japan had lower rates of CHD than Japanese Americans in Hawaii. Rates of CHD appear to continue to be lower in Japan despite increasing cholesterol levels in Japan and decreasing CHD rates in the United States.


OBJECTIVE
To provide insight into CHD rate differences.


METHODS
Nuclear Magnetic Resonance (NMR) measurements of lipoprotein subclasses were used to assess lipoprotein particle concentration and size in samples from these two genetically similar populations in Japan and Hawaii.


RESULTS
Japanese Americans had significantly higher age- and risk factor- adjusted concentrations of lipoprotein particles implicated in atherogenesis, including large very low density lipoprotein (VLDL; P < 0.001), small LDL (P < 0.001), and small HDL (women, P < 0.001; men, P < 0.01), and significantly lower concentrations of large LDL (P < 0.001) and the putative cardio-protective large HDL (P < 0.05) than Japanese in Japan. Average age- and risk factor- adjusted LDL and HDL particle sizes were also significantly (P < 0.001) smaller in Japanese Americans. Adjustment for body mass index markedly reduced the differences in some lipoprotein measures, including total LDL and large HDL particle concentrations for both genders, total VLDL particle concentration for women, and large VLDL concentration and average HDL particle size for men.


CONCLUSIONS
Differences in lipoprotein subclass distributions and lifestyle factors such as body weight may contribute to differences in CHD incidence for Japanese in Japan and Japanese Americans.
Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, 347 N. Kuakini St HPM9, Honolulu, HI 96817, USA. curb@hawaii.edu
J David
JD
Curb
Hirotsugu
H
Ueshima
Beatriz L
BL
Rodriguez
Qimei
Q
He
Tanya A
TA
Koropatnick
Hideaki
H
Nakagawa
Kiyomi
K
Sakata
Shigeyuki
S
Saitoh
Akira
A
Okayama
D000328:Adult; D001213:Asian; D044466:Asian People; D001837:Body Weights and Measures; D003710:Demography; D005260:Female; D006254:Hawaii; D006801:Humans; D007564:Japan; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010316:Particle Size; D012307:Risk Factors
D008074:Lipoproteins
Am J Cardiol. 2002 Oct 17;90(8A):71i-76i
12419483
Am J Cardiol. 2002 Jul 15;90(2):89-94
12106834
Diabetes. 2002 Jun;51(6):1949-56
12031985
Clin Lab. 2002;48(3-4):171-80
11934219
Circulation. 2002 Oct 8;106(15):1930-7
12370215
J Atheroscler Thromb. 2004;11(6):304-12
15644583
Arterioscler Thromb Vasc Biol. 1998 Jul;18(7):1046-53
9672064
Clin Lab Med. 2006 Dec;26(4):847-70
17110242
J Hum Hypertens. 1991 Aug;5(4):317-32
1956029
Lipids. 2010 Oct;45(10):907-14
20524075
Am J Cardiol. 2002 Oct 17;90(8A):22i-29i
12419478
JAMA. 2003 Oct 15;290(15):2030-40
14559957
Curr Atheroscler Rep. 2005 Nov;7(6):455-9
16256003
Jpn Circ J. 2001 Oct;65(10):887-92
11665793
Acta Cardiol. 1990;45(4):311-27
2239030
J Hum Hypertens. 2003 Sep;17(9):609-22
13679951
J Hum Hypertens. 2003 Sep;17(9):591-608
13679950
Am J Epidemiol. 1988 Mar;127(3):476-87
3341354
Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1175-80
12117734
Clin Chem. 1992 Sep;38(9):1632-8
1326420
Lancet. 1999 May 8;353(9164):1547-57
10334252
Atherosclerosis. 2003 Jan;166(1):67-72
12482552
Clin Cardiol. 1999 Jun;22(6 Suppl):II21-7
10376193
J Hum Hypertens. 2003 Sep;17(9):631-9
13679953
Curr Atheroscler Rep. 2004 Sep;6(5):381-7
15296705
Heart. 2003 Mar;89(3):255-7
12591821
J Nutr. 2003 Nov;133(11):3428-33
14608054