A case of Takayasu's arteritis associated with human leukocyte antigen A24 and B52 following resolution of ulcerative colitis and subacute thyroiditis.
A 46-year-old female with a past history of ulcerative colitis (UC) was diagnosed with subacute thyroiditis (SAT), which improved with prednisolone (PSL) treatment (60 mg/day). The dose of PSL was gradually decreased, however upper back and neck pain and chest discomfort developed. The patient was diagnosed with Takayasu's arteritis (TA) based on wall thickening and luminal narrowing of the left common carotid artery and the left subclavian artery. The result of human leukocyte antigen typing analysis was A24 and B52 positive. These findings suggested that common genetic factors may be important for the etiology of TA, UC and SAT. This is the first report of TA that developed following UC and SAT.
Department of Internal Medicine and Rheumatology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, Japan. yoshirohorai0518@qmed.hosp.go.jp
Yoshiro
Y
Horai
Tomoya
T
Miyamura
Karin
K
Shimada
Soichiro
S
Takahama
Rumi
R
Minami
Masahiro
M
Yamamoto
Eiichi
E
Suematsu
D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood* / Q000175:diagnosis; D005260:Female; D059871:HLA-A24 Antigen / Q000097:blood*; D059950:HLA-B52 Antigen / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D013625:Takayasu Arteritis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D013968:Thyroiditis, Subacute / Q000097:blood* / Q000175:diagnosis
D015415:Biomarkers; D059871:HLA-A24 Antigen; D059950:HLA-B52 Antigen