Detection of an Ambler class D OXA-48-type β-lactamase in a Klebsiella pneumoniae strain in The Netherlands.
Traditionally, bacteria in The Netherlands have low levels of resistance to antibiotics. This report describes what is believed to be the first carbapenem-resistant Klebsiella pneumoniae producing an OXA-48 type β-lactamase in The Netherlands. The isolate co-produced a CTX-M-15 type β-lactamase and was recovered from a patient who was transferred from a hospital in India to an intensive care unit in The Netherlands. His recovery in The Netherlands was complicated by pneumonia due to the carbapenem-resistant K. pneumoniae to which he eventually succumbed. Pre-emptive screening for carbapenem-resistant Enterobacteriaceae in selected patients could be imperative to maintain the low prevalence of these highly resistant bacteria in Dutch hospitals.
Department of Medical Microbiology and Infection Prevention, Saint Lucas Andreas Hospital, Amsterdam, The Netherlands.
Jayant S
JS
Kalpoe
Microbiology Laboratory Twente Achterhoek, Enschede, The Netherlands.
Nashwan
N
Al Naiemi
Service de Bactériologie-Virologie-Hygiène, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Laurent
L
Poirel
Service de Bactériologie-Virologie-Hygiène, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Patrice
P
Nordmann
D015780:Carbapenems / Q000494:pharmacology; D017809:Fatal Outcome; D006801:Humans; D007194:India / Q000208:ethnology; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009426:Netherlands; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D014195:Travel; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis / Q000145:classification*
D015780:Carbapenems; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases