Insulin resistance and metabolic syndrome in prepubertal boys with Klinefelter syndrome.
OBJECTIVE
To investigate risk factors for metabolic syndrome in prepubertal boys with Klinefelter syndrome.


METHODS
Eighty-nine boys with Klinefelter syndrome, ages 4-12.9 years, and 34 age-matched control boys had height, weight, waist circumference and blood pressure measured and their parents completed a questionnaire about physical activity. The boys with Klinefelter syndrome also had measurement of lipids, fasting glucose and insulin. Insulin-glucose homeostasis model assessment was calculated, and the boys were evaluated for childhood metabolic syndrome.


RESULTS
The Klinefelter syndrome and control groups were similar ages (7.5 ± 2.4 vs. 8.1 ± 2.3 years). Body mass index measurements were similar, but waist circumference was >90 percentile in 30% of boys with Klinefelter syndrome versus 21% of controls. The mean daily time spent running was 42 min less in the Klinefelter syndrome versus control groups (p < 0.01). About 37% of the boys with Klinefelter syndrome had elevated LDL cholesterol, 24% had insulin resistance, and 7% met the three criteria for diagnosis of metabolic syndrome.


CONCLUSIONS
Truncal obesity, insulin resistance and metabolic syndrome are present in boys as young as 4-12 years with Klinefelter syndrome, and these occur in association with reduced running-type activity.
Pediatrics, Thomas Jefferson University/Nemours, Philadelphia, PA, USA.
Martha Z
MZ
Bardsley
Bonita
B
Falkner
Karen
K
Kowal
Judith L
JL
Ross
D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D007713:Klinefelter Syndrome / Q000150:complications* / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis; D056128:Obesity, Abdominal; D012307:Risk Factors; D012420:Running / Q000706:statistics & numerical data; D013997:Time Factors; D055105:Waist Circumference
D008078:Cholesterol, LDL
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