Gold nanorod light scattering labels for biomedical imaging.
Gold nanorods can be used as extremely bright labels for differential light scattering measurements using two closely spaced wavelengths, thereby detecting human disease through several centimeters of tissue in vivo. They have excellent biocompatibility, are non-toxic, and are not susceptible to photobleaching. They have narrow, easily tunable plasmon spectral lines and thus can image multiple molecular targets simultaneously. Because of their small size, gold nanorods can be transported to various tissues inside the human body via the vasculature and microvasculature, and since they are smaller than vascular pore sizes, they can easily cross vascular space and enter individual cells.
Le
L
Qiu
Timothy A
TA
Larson
Edward
E
Vitkin
Lianyu
L
Guo
Eugene B
EB
Hanlon
Irving
I
Itzkan
Konstantin V
KV
Sokolov
Lev T
LT
Perelman
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17255-60
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