Ceftriaxone resistant Shigella flexneri, an emerging problem.
Shigellosis is a disease of public health importance in developing countries. It may cause self-limited diarrhea to severe dysentery. Emergence of multi drug resistant (MDR) strains is a growing concern globally. Ceftriaxone and ciprofloxacin are the drugs of choice for MDR cases. Here, we report a case of MDR Shigella flexneri from an immunocompromised patient. The strain was resistant to ceftriaxone [minimum inhibitory concentration (MIC) ≥ 64 μg/ml], limiting the treatment option. Simultaneously, the strain was also found to be resistant to ciprofloxacin (MIC ≥ 4 μg/ml). However, it was susceptible to ceftazidime (MIC 4 μg/ml). This is the first case of ceftriaxone resistant Shigella spp. reported from our hospital.
Department of Microbiology, St. John's Medical College, Bangalore - 560 034, India.
Soham
S
Gupta
Baijayanti
B
Mishra
Sethumadhavan
S
Muralidharan
Hiresave
H
Srinivasa
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002442:Ceftazidime / Q000494:pharmacology / Q000627:therapeutic use; D002443:Ceftriaxone / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012763:Shigella flexneri / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D002442:Ceftazidime