14-3-3ζ positive expression is associated with a poor prognosis in patients with glioblastoma.
BACKGROUND
When identifying clinical markers predicting clinical outcome, disease recurrence and resistance to therapies often determine the diagnosis and therapy of some cancer types.


OBJECTIVE
To investigate whether 14-3-3zeta positive expression is an indicator of prognosis in patients with glioblastoma.


METHODS
Forty-seven patients treated with surgery, radiotherapy, and adjuvant chemotherapy between 2005 and 2007 were divided into 2 groups according to 14-3-3zeta expression in an immunohistochemical study: the 14-3-3zeta negative group (n = 12 patients) and the 14-3-3zeta positive group (n = 35 patients). The clinicopathologic features and survival data for patients in the 14-3-3zeta positive group were compared with data from the patients in the 14-3-3zeta negative group. Kaplan-Meier survival analysis and univariate and multivariate analyses were performed to determine the prognostic factors that influenced patient survival.


RESULTS
14-3-3zeta positive expression was observed in approximately 74.5% of patients with glioblastoma. Patients in the 14-3-3zeta positive group had lower overall survival rates and median survival time than those in the 14-3-3zeta negative group (overall 2-year actuarial survival rates, 8.6% for the 14-3-3zeta positive group vs 16.7% for the 14-3-3zeta negative group; overall 2-year median survival time, 12.9 months for the 14-3-3zeta positive group vs 17.9 months for the 14-3-3zeta negative group, P = .019). 14-3-3zeta positive expression in tumor cells also was correlated with a shorter interval to tumor recurrence (median interval to recurrence, 5.9 months in the 14-3-3zeta positive group vs 8.3 months in the 14-3-3zeta negative group, P = .002). Univariate and multivariate analyses showed that 14-3-3zeta positive expression was an independent prognostic factor.


CONCLUSIONS
14-3-3zeta positive expression can be used as a potential molecular risk factor in patients with glioblastoma.
Institute of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xían, Shaanxi Province, People's Republic of China.
Xiaoliang
X
Yang
Weidong
W
Cao
Jie
J
Zhou
Wei
W
Zhang
Xiang
X
Zhang
Wei
W
Lin
Zhou
Z
Fei
Hong
H
Lin
Bo
B
Wang
D048948:14-3-3 Proteins / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005909:Glioblastoma / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate / Q000639:trends; D055815:Young Adult
D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor