[Massive hepatic infarction occurred during the myelosuppression after re-induction chemotherapy for acute myeloid leukemia].
Since the liver has a duplicate blood supply through the hepatic artery and portal vein, hepatic infarction is considered a rare disease. A 51-year-old male with acute myeloid leukemia and diabetes mellitus developed fulminant hepatic infarction only a few days after administration of FLAGM chemotherapy. Our case was considered to have been caused by the almost complete obstruction of both the hepatic artery and portal vein by thrombi during a short period. Hepatic infarction should be recognized as a complication that may develop after salvage chemotherapy such as FLAGM inducing marked myelosuppression. Hepatic infarction after chemotherapy requires further analysis by evaluating a larger number of cases.
Department of Internal Medicine, Aiiku Hospital, Japan.
Makoto
M
Saito
Akio
A
Mori
Tatsuro
T
Irie
Masanori
M
Tanaka
Masanobu
M
Morioka
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D006499:Hepatic Artery; D006801:Humans; D007238:Infarction / Q000209:etiology*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008099:Liver / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D016879:Salvage Therapy; D013927:Thrombosis / Q000209:etiology