Evaluation of the toxicity of Adonis aestivalis in sheep.
To determine the toxicity of Adonis aestivalis (adonis) in sheep, adult Suffolk ewes were administered 1 per cent bodyweight adonis via surgically placed rumen cannulas in an acute, high-dose toxicity study, and 0.2 per cent bodyweight daily in a two-week, low-dose toxicity study. The ewes received cardiac examinations before dosing, 24 and 48 hours after dosing with 1 per cent bodyweight adonis, and after continuous low-dose administration. All the ewes administered adonis had transient sinus arrhythmias after receiving 1 per cent bodyweight adonis. Two of the three ewes had transient reduced fractional shortening after administration with 1 per cent bodyweight adonis; the same two ewes had reduced fractional shortening after the low-dose treatment regimen. No gross or microscopic lesions were seen when the ewes were examined postmortem at the end of the study.
California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, PO Box 1770, Davis, CA 95617, USA. lwwoods@ucdavis.edu
L W
LW
Woods
B
B
Puschner
M S
MS
Filigenzi
D M
DM
Woods
L W
LW
George
D031843:Adonis / Q000506:poisoning / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D010939:Plant Poisoning / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000473:pathology; D018675:Toxicity Tests / Q000662:veterinary*