[Clinical utility of an antimicrobial blocking solution in patients with an indwelling catheter].
OBJECTIVE
Patients with indwelling catheters have a substantial long-term risk for catheter incrustation and blockage. Chronic bacteriuria is regarded as a risk factor for this complication. Until today, there are no effective prophylactic measures. We evaluated the effect of a triclosan-containing fluid for inflation of the catheter balloons (Farco-fill® Protect) on the extent of bacteriuria in a clinical setting.


METHODS
In a prospective multicentre study, between 7 / 2009 and 3 / 2010, the effect of Farco-fill® Protect on urine culture was evaluated in 62 patients with indwelling catheters.


RESULTS
55 patients could be completely evaluated. With use of Farco-fill® Protect, urinary pH, and urine volume / 24 hours remained unchanged. The number of patients with > 10 (5) colony forming units / mL was reduced from 70.9 % to 45.5 %. In 34.5 % the extent of catheter incrustations could be reduced.


CONCLUSIONS
This study is the first to demonstrate a marked reduction of bacteriuria and catheter incrustations with the help of a triclosan-containing fluid in a clinical setting. Long-term studies are necessary to determine whether or not the afore-mentioned effect leads to less catheter occlusions.This finding would have positive medical as well as economic aspects.
Neuro-Urologie, Schweizer Paraplegiker-Zentrum, Nottwil, Schweiz. juergen.pannek@paranet.ch
J
J
Pannek
A-M
AM
Vestweber
D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage*; D001437:Bacteriuria / Q000188:drug therapy* / Q000382:microbiology; D002408:Catheters, Indwelling / Q000382:microbiology*; D003114:Colony-Forming Units Assay; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013557:Switzerland; D014260:Triclosan / Q000008:administration & dosage*; D014546:Urinary Catheterization
D000892:Anti-Infective Agents, Urinary; D014260:Triclosan