Recombinant S3Pvac-phage anticysticercosis vaccine: Simultaneous protection against cysticercosis and hydatid disease in rural pigs.
This paper provides macroscopic and histological evidence on the statistically significant protective effects of S3Pvac-phage vaccination against porcine cysticercosis and hydatidosis. The study included 391 rustically bred pigs (187 vaccinated and 204 controls). Vaccination significantly reduced the prevalence of cysticercosis by 61.7%. Vaccination also significantly reduced by 56.1% the prevalence of hydatidosis caused by Echinococcus granulosus in pigs. The presence of the vaccine epitopes in both cestodes is probably involved in the cross-protection observed. Increased inflammation was found in 5% of cysticerci recovered from controls, versus 24% from vaccinated pigs (P<0.01). Hydatid cysts were non-inflammatory in either group. Vaccination was effective to prevent one single disease, but it failed to prevent the simultaneous infections with both parasites in a same pig. The widening of the S3Pvac-phage vaccine protective repertoire to include hydatidosis is a convenient feature that should reduce the prevalence of two frequent zoonoses that affect rustic porcine breading with a single action. Thus, the costs of two different vaccination programs would be reduced to a single one with significant reduction in both zoonoses.
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de Mexico, Mexico, Mexico.
Julio
J
Morales
Aline S
AS
de Aluja
Jose Juan
JJ
Martínez
Marisela
M
Hernández
Gabriela
G
Rosas
Nelly
N
Villalobos
Beatriz
B
Hernández
Abel
A
Blancas
Karen
K
Manoutcharian
Goar
G
Gevorkian
Jacquelynne
J
Cervantes
Alicia
A
Díaz
Agnes
A
Fleury
Gladis
G
Fragoso
Carlos
C
Larralde
Edda
E
Sciutto
D000818:Animals; D003551:Cysticercosis / Q000517:prevention & control / Q000662:veterinary*; D004443:Echinococcosis / Q000517:prevention & control / Q000662:veterinary*; D015801:Helminth Proteins / Q000235:genetics / Q000276:immunology*; D011994:Recombinant Proteins; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology / Q000517:prevention & control*; D014612:Vaccines / Q000276:immunology*
D015801:Helminth Proteins; D011994:Recombinant Proteins; D014612:Vaccines