Hormonal reaction of the testes to chorionic gonadotropin in CBA/Lac and PT mice: effects of the dose and time after treatment.
Testosterone concentrations in the blood of CBA/Lac and PT mice and its content in the testes under normal conditions and during stimulation with chorionic gonadotropin were measured by enzyme immunoassay. Genetic differences in reactivity of the testes to chorionic gonadotropin were revealed: PT mice were characterized by more pronounced hormonal reaction compared to CBA/Lac mice. An optimal dose of chorionic gonadotropin (10 U) and time interval (120 min) for evaluation of potentialities of testicular hormonal function were determined.
Laboratory of Endocrinological Genetics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. edubovenko@gmail.com
E A
EA
Dubovenko
L V
LV
Osadchuk
D000704:Analysis of Variance; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007124:Immunoenzyme Techniques; D007985:Leydig Cells / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013045:Species Specificity; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D006063:Chorionic Gonadotropin; D013739:Testosterone