Specificity of verbal learning impairment and recovery in a marijuana-dependent male: the effects of sustained marijuana abstinence.
BACKGROUND
We present the case of a young adult in treatment for marijuana dependence, with recurrent depression and a history of possible traumatic brain injury, complaining of concentration, memory, and initiation problems.


METHODS
The patient was assessed longitudinally during treatment with a brief neuropsychological battery, as well as measures of marijuana use and mood.


RESULTS
Testing at treatment baseline revealed performance that was generally in the high average range or higher on measures of reaction time and attention, with a selective impairment in verbal learning (borderline to extremely low range). Following 8 weeks of abstinence from marijuana, his verbal learning recovered to expected levels (high average range), with signs of improved learning strategy, efficiency, rate, and capacity. However, his reaction time and attention showed minimal evidence of change.


CONCLUSIONS
This finding is consistent with the literature that demonstrates that marijuana-associated neurocognitive impairments may be most pronounced in the domain of verbal learning and may remit with abstinence. The clinical implications of these case findings and recommendations for neuropsychological assessment of marijuana abusers are discussed.
Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA. npv2101@columbia.edu
Nehal P
NP
Vadhan
Wilfred G
WG
van Gorp
Frances R
FR
Levin
D000293:Adolescent; D000428:Alcohol Drinking / Q000523:psychology; D001288:Attention / Q000187:drug effects; D001519:Behavior / Q000187:drug effects; D001714:Bipolar Disorder / Q000150:complications / Q000209:etiology / Q000523:psychology; D003072:Cognition Disorders / Q000139:chemically induced / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D007859:Learning Disabilities / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology*; D008297:Male; D002189:Marijuana Abuse / Q000175:diagnosis / Q000523:psychology*; D009483:Neuropsychological Tests; D020127:Recovery of Function; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult
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