Fatal necrotizing pneumonia caused by Panton-Valentine leukocidin-producing hospital-acquired Staphylococcus aureus: a case report.
Panton-Valentine leukocidin (PVL) is a cytotoxin which causes leukocyte destruction and tissue necrosis. Although it is produced by fewer than 5% of Staphylococcus aureus strains, PVL-producing S. aureus is emerging as a serious problem worldwide. There has been a marked increase in the incidence of necrotizing lung infections with a very high mortality associated with these strains. This report describes a fatal case of hospital-acquired necrotizing pneumonia caused by PVL-positive methicillin-susceptible S. aureus in a patient with a brain tumor.
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. hassanainiy@yahoo.com
Hassanain
H
Al-Talib
Habsah
H
Hasan
Chan Yean
CY
Yean
Sami M
SM
Al-Ashwal
Manickam
M
Ravichandran
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001427:Bacterial Toxins / Q000096:biosynthesis*; D001932:Brain Neoplasms / Q000150:complications; D003428:Cross Infection / Q000382:microbiology*; D005098:Exotoxins / Q000096:biosynthesis*; D017809:Fatal Outcome; D006801:Humans; D007956:Leukocidins / Q000096:biosynthesis*; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011023:Pneumonia, Staphylococcal / Q000382:microbiology* / Q000473:pathology; D013203:Staphylococcal Infections / Q000150:complications / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism* / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D008712:Methicillin