The Escherichia coli K-12 MntR miniregulon includes dps, which encodes the major stationary-phase DNA-binding protein.
Escherichia coli MntR protein is the Mn(2+)-responsive transcriptional repressor of the MntH manganese transporter. We have used chromatin immunoprecipitation to determine the distribution of Mn(2+)-MntR across the entire E. coli chromosome in vivo, and we report that MntR binds to only four targets, adjacent to the mntH, mntR, yebN, and dps genes. Unexpectedly, we found that dps expression is directly repressed by Mn(2+)-MntR.
Department of Frontier Bioscience and Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo 184-8584, Japan.
Kaneyoshi
K
Yamamoto
Akira
A
Ishihama
Stephen J W
SJ
Busby
David C
DC
Grainger
D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis*; D047369:Chromatin Immunoprecipitation; D002876:Chromosomes, Bacterial; D004269:DNA, Bacterial / Q000378:metabolism; D048168:Escherichia coli K12 / Q000235:genetics* / Q000502:physiology; D029968:Escherichia coli Proteins / Q000096:biosynthesis* / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D011485:Protein Binding; D018085:Regulon; D012097:Repressor Proteins / Q000378:metabolism*
D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; C499677:MntR protein, E coli; D012097:Repressor Proteins; C088010:dps protein, E coli
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