The unfolded protein response in mouse cerebral cortex.
The unfolded protein response (UPR) is important for normal cellular homeostasis, development, and physiology. Endoplasmic reticulum stress and the UPR have also been implicated in a variety of diseases and pathologies. Thus the UPR is being studied in many model systems. We describe in this chapter methods for studying the UPR in a mouse model, specifically the cerebral cortex of mouse brain.
Center for Sleep and Circadian Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Nirinjini
N
Naidoo
D051702:Activating Transcription Factor 6 / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology*; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology; D051742:Transcription Factor CHOP / Q000502:physiology; D056811:Unfolded Protein Response; D019892:eIF-2 Kinase / Q000502:physiology*
D051702:Activating Transcription Factor 6; D000091342:Endoplasmic Reticulum Chaperone BiP; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D017346:Protein Serine-Threonine Kinases; D051742:Transcription Factor CHOP; D019892:eIF-2 Kinase; C497250:Ddit3 protein, mouse; C486556:Ern2 protein, mouse