[Comparative efficacy of selective serotonin reuptake inhibitors in young prenatally stressed female rats].
Effects of the chronic administration of selective serotonin reuptake inhibitors (SSRIs) fluoxetine (daily 5.0 mg/kg, p.o.) and paroxetine (daily 5.0 mg/kg, p.o.) for 14 days of postnatal period on anxiety-like behavior have been studied during pubertal period in prenatally stressed female rats. It was found that prenatal stress reduced the anxiety level in test rats. Chronic administration of paroxetine in female rats did not change their anxiety-like behavior. Administration of fluoxetine resulted in an anxiogenic effect, but leveled an action of prenatal stress on the anxiety-like behavior in prenatally stressed female rats during pubertal period.
N É
NÉ
Ordian
S G
SG
Pivina
Iu O
IuO
Fedotova
V K
VK
Akulova
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001007:Anxiety / Q000188:drug therapy / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D017374:Paroxetine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012741:Sexual Maturation / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy / Q000503:physiopathology*
D014151:Anti-Anxiety Agents; D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors