p53 and its mutants in tumor cell migration and invasion.
In about half of all human cancers, the tumor suppressor p53 protein is either lost or mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 protein. Loss of p53 function is well known to influence cell cycle checkpoint controls and apoptosis. But it is now clear that p53 regulates other key stages of metastatic progression, such as cell migration and invasion. Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function.
Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK.
Patricia A J
PA
Muller
Karen H
KH
Vousden
Jim C
JC
Norman
D000818:Animals; D002465:Cell Movement / Q000235:genetics*; D006801:Humans; D050505:Mutant Proteins / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
D050505:Mutant Proteins; D016159:Tumor Suppressor Protein p53
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