Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing.
The purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar formation. In contrast, fetal wound repair occurs with minimal inflammation, faster re-epithelialization, and without the accumulation of scar. Although research into scarless healing began decades ago, the critical molecular mechanisms driving the process of regenerative fetal healing remain uncertain. Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring.
Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA.
Latha
L
Satish
Sandeep
S
Kathju
Wound Repair Regen. 2008 May-Jun;16(3):450-9
18471263
Nature. 1992 Nov 12;360(6400):179-83
1436096
J Pediatr Surg. 1994 Nov;29(11):1405-8
7844707
Lab Invest. 2008 Jun;88(6):579-90
18427552
Wound Repair Regen. 1999 Nov-Dec;7(6):423-32
10633001
J Cell Sci. 1994 May;107 ( Pt 5):1159-67
7929625
Curr Biol. 2003 Jul 1;13(13):1122-8
12842011
Ostomy Wound Manage. 2007 Jun;53(6):16-31; quiz 32-3
17586870
J Cell Biol. 1990 Nov;111(5 Pt 1):2139-48
2121746
Genes Cells. 2005 Nov;10(11):1081-91
16236136
FASEB J. 2006 Nov;20(13):2366-8
16966487
Plast Reconstr Surg. 2003 Jun;111(7):2273-85
12794470
J Pediatr Surg. 2000 Mar;35(3):406-19
10726679
Am J Pathol. 1993 Nov;143(5):1458-69
7694470
J Pediatr Surg. 1998 Feb;33(2):312-6
9498408
Plast Reconstr Surg. 2003 May;111(6):1969-79
12711959
J Pediatr Surg. 1987 Jul;22(7):640-4
3302202
Am J Pathol. 2000 Aug;157(2):423-33
10934147
Eur J Dermatol. 2001 Sep-Oct;11(5):424-31
11525949
World J Surg. 1992 Jan-Feb;16(1):87-96
1290271
J Trauma. 2004 Dec;57(6):1276-86
15625461
Cell Motil Cytoskeleton. 2007 Apr;64(4):248-57
17183543
J Cell Biol. 2003 Oct 27;163(2):327-37
14568992
Differentiation. 1997 Oct;62(1):33-41
9373945
Arch Dermatol Res. 2010 Jan;302(1):47-55
19701759
Dev Biol. 1995 May;169(1):242-60
7750642
Tissue Cell. 1993;25(2):173-81
8511764
Plast Reconstr Surg. 1995 Nov;96(6):1251-9; discussion 1260-1
7480221
Mech Dev. 1992 Sep;38(3):209-15
1457382
Plast Reconstr Surg. 2005 Jan;115(1):204-12
15622252
Wound Repair Regen. 2003 Jan-Feb;11(1):46-54
12581426
J Invest Dermatol. 2003 Jun;120(6):1118-29
12787143
Pediatr Dermatol. 1986 Dec;3(6):487-91
3562363
J Invest Dermatol. 2003 Jun;120(6):1130-7
12787144
Cell. 1986 Jul 18;46(2):155-69
3013421
J Burn Care Rehabil. 1997 Mar-Apr;18(2):164-71
9095428
J Pediatr Surg. 1991 Jul;26(7):853-5
1895198
DNA Cell Biol. 2007 Apr;26(4):227-37
17465889
J Oral Maxillofac Surg. 2010 Apr;68(4):751-5
20044189
J Pediatr Surg. 2000 Feb;35(2):183-7; discussion 187-8
10693663
Dev Biol. 1995 Jul;170(1):102-14
7601301
Science. 1994 Nov 4;266(5186):819-22
7973639
Ann Plast Surg. 2010 Feb;64(2):247-50
20098115
Cell. 1988 May 6;53(3):383-90
2452695
J Clin Pediatr Dent. 1998 Fall;23(1):69-74
10023238
Front Biosci. 2008 Jan 01;13:51-61
17981527
Wound Repair Regen. 2007 Jan-Feb;15(1):147-55
17244330
Wound Repair Regen. 2006 Jul-Aug;14(4):413-20
16939568
J Cell Sci. 1991 Jul;99 ( Pt 3):583-6
1719005
Development. 1991 Jun;112(2):651-68
1724421
J Pediatr Surg. 1994 Mar;29(3):416-21
7515416
Int J Tissue React. 1988;10(6):367-72
2475451
J Cell Biol. 1996 Nov;135(4):1097-107
8922389
Adv Biochem Eng Biotechnol. 2005;93:83-100
15791945
Development. 1990 Nov;110(3):671-80
2088714
Anat Rec. 1954 Aug;119(4):435-47
13283319
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167-71
2424019
J Pediatr Surg. 2001 Nov;36(11):1666-71
11685698
Arch Dermatol Res. 2010 Jul;302(5):319-39
20130896
Dev Dyn. 1998 Jul;212(3):385-93
9671942
J Cell Biol. 1992 Dec;119(5):1017-21
1332976
J Cell Biochem. 1984;26(2):107-16
6084665
Burns. 2009 Feb;35(1):15-29
18952381
Ann Surg. 1995 Aug;222(2):146-54
7639582
Wound Repair Regen. 2008 Jan-Feb;16(1):70-9
18086289
Cell Mol Biol (Noisy-le-grand). 1998 Sep;44(6):961-71
9763200
Ann Surg. 1994 Jan;219(1):65-72
8297179
Plast Reconstr Surg. 2006 Oct;118(5):1125-1129
17016177
Vet Dermatol. 2001 Dec;12(6):303-13
11844219
Virchows Arch A Pathol Anat Histol. 1979 Mar 23;381(3):353-61
155931
Int J Oral Maxillofac Surg. 1993 Dec;22(6):371-4
8106816
J Invest Dermatol. 1990 Jun;94(6 Suppl):128S-134S
2161886
Clin Podiatr Med Surg. 2001 Jan;18(1):147-59
11344975
J Pediatr Surg. 1996 Jan;31(1):91-5
8632294
Invest Ophthalmol Vis Sci. 1979 Aug;18(8):767-84
457355
J Cell Biol. 1993 Jul;122(1):103-11
8314838
Cell Stress Chaperones. 2008 Dec;13(4):527-33
18465209
J Invest Dermatol. 2007 Mar;127(3):526-37
17299435
J Cell Biochem. 2003 Aug 15;89(6):1126-37
12898511
Ann Plast Surg. 1997 Oct;39(4):374-80
9339280
Cytokine. 2000 Jun;12(6):671-6
10843743
Plast Reconstr Surg. 1981 Jul;68(1):107-13
7017779
South Med J. 1970 Jul;63(7):755-60
5427162
J Leukoc Biol. 2003 Apr;73(4):448-55
12660219
PLoS One. 2010 Apr 30;5(4):e10063
20442790
Lancet. 2009 Apr 11;373(9671):1264-74
19362676
J Cell Biol. 1996 Jan;132(1-2):239-49
8567727
J Pediatr Surg. 1988 Jul;23(7):647-52
3204464
J Pediatr Surg. 1995 Feb;30(2):198-202; discussion 202-3
7738738
J Invest Dermatol. 2008 Jul;128(7):1852-60
18200061
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4894-7
3164478
Wound Repair Regen. 2006 Jul-Aug;14(4):463-70
16939575
Am J Pathol. 1995 Jan;146(1):56-66
7856739
J Pediatr Surg. 2000 Jun;35(6):866-72; discussion 872-3
10873028
Am J Pathol. 2004 Sep;165(3):753-61
15331400
J Pediatr Surg. 1990 Jan;25(1):63-8; discussion 68-9
2299547
West J Med. 1993 Sep;159(3):350-5
8236977
J Cell Biol. 1993 Feb;120(3):577-85
8381117
J Burn Care Rehabil. 1996 Jul-Aug;17(4):338-45
8844355
Ann Plast Surg. 1992 Aug;29(2):178-81
1530272
J Cell Sci. 1995 Mar;108 ( Pt 3):985-1002
7542672