Alzheimer's disease and glaucoma: imaging the biomarkers of neurodegenerative disease.
Imaging through the visual system in Alzheimer's disease, with the technology currently in widespread use for the diagnosis and management of eye disease such as glaucoma and macular degeneration, is proving to be promising. In vivo cross-section imaging during an annual comprehensive eye exam has been available for a decade for glaucoma and macular degeneration, and this same imaging, using Optical Coherence Tomography, has been demonstrated to show deficits specific to AD and mild cognitive impairment. These deficits are in the form of nerve fiber layer tissue drop out in the retina and optic nerve. The retrograde loss of nerve fiber layer tissue in the retina and optic nerve may be an early biomarker of AD, and these deficits in the nerve fiber layer of the retina and optic nerve may be the earliest sign of AD, even prior to damage to the hippocampal region that impacts memory.
Vision Care, 62 Forest Avenue Quincy, MA 02169, USA.
Denise A
DA
Valenti
Neurobiol Aging. 1996 May-Jun;17(3):385-95
8725900
Arch Gen Psychiatry. 2001 Apr;58(4):353-60
11296096
Am J Ophthalmol. 1993 Jul 15;116(1):113-4
8328536
Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3216-22
11726625
N Engl J Med. 1986 Aug 21;315(8):485-7
3736630
Am J Ophthalmol. 1994 Mar 15;117(3):342-7
8129008
J Neuroophthalmol. 2006 Mar;26(1):18-24
16518161
Invest Ophthalmol Vis Sci. 2007 May;48(5):2285-9
17460292
Curr Opin Ophthalmol. 2010 Mar;21(2):106-11
20040876
Psychiatry Res. 1993 Sep;48(3):277-92
8272449
Invest Ophthalmol Vis Sci. 1999 Sep;40(10):2439-42
10476816
Ophthalmology. 2008 Dec;115(12):2316-7; author reply 2317
19041485
Optom Vis Sci. 1996 Nov;73(11):677-82
8950748
Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1421-8
16439671
Prog Brain Res. 1992;93:151-62; discussion 162-3
1480747
Neurology. 2007 Sep 4;69(10):1060
17785676
J Gerontol. 1994 Mar;49(2):P52-7
8126359
Eye (Lond). 2002 Mar;16(2):209-12
11988832
Clin Neurol Neurosurg. 2008 Jul;110(7):753-4
18603354
Curr Opin Neurol. 2010 Feb;23(1):16-23
20009925
Ann N Y Acad Sci. 1991;640:28-35
1776752
Ophthalmology. 1990 Jan;97(1):9-17
2314849
J Glaucoma. 1998 Apr;7(2):128-31
9559500
Br J Ophthalmol. 1995 Jun;79(6):596-600
7542917
Am J Psychiatry. 1996 Oct;153(10):1261-8
8831432
Clin Neurol Neurosurg. 2008 Feb;110(2):101-9
18061341
Vision Res. 2004 Nov;44(24):2793-7
15342223
Optometry. 2010 Jan;81(1):12-21
20004873
Arch Neurol. 2003 Aug;60(8):1119-22
12925369
J Neurol Sci. 2006 Jul 15;246(1-2):79-83
16564058
Arch Ophthalmol. 1991 Feb;109(2):199-204
1993028
Brain Res. 1985 Sep 2;342(1):37-44
4041816
Ophthalmology. 2002 May;109(5):1009-17
11986111
Neurobiol Aging. 2000 Nov-Dec;21(6):867-9; discussion 875-7
11124432
Am J Public Health. 1994 Aug;84(8):1261-4
8059882
Ophthalmology. 2001 Jan;108(1):139-44
11150279
Dement Geriatr Cogn Disord. 2001 Nov-Dec;12(6):359-63
11598306
Invest Ophthalmol Vis Sci. 2000 May;41(6):1370-9
10798652
Invest Ophthalmol Vis Sci. 1999 Sep;40(10):2242-50
10476789
Science. 2002 Feb 8;295(5557):1070-3
11834835
J Geriatr Psychiatry Neurol. 1995 Apr;8(2):103-6
7794472
Neurosci Lett. 2010 Aug 9;480(1):69-72
20609426
Acta Ophthalmol Scand. 2001 Apr;79(2):187-91
11284761
Science. 1991 Nov 22;254(5035):1178-81
1957169
Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5189-95
14638716
Am J Ophthalmol. 1993 Aug 15;116(2):182-8
8352303
Neurology. 1995 Jan;45(1):68-74
7824139
Eur J Ophthalmol. 2007 Sep-Oct;17(5):812-6
17932860
Acta Ophthalmol Scand. 1996 Jun;74(3):271-5
8828725
Ophthalmologica. 1998;212(2):115-9
9486551
Ophthalmology. 2008 Dec;115(12):2317-8; author reply 2318
19041488
Clin Neurophysiol. 2001 Oct;112(10):1860-7
11595144
J Neuropathol Exp Neurol. 2006 Jun;65(6):621-30
16783172
Doc Ophthalmol. 2008 Mar;116(2):137-46
17962989
Neuropathol Appl Neurobiol. 1995 Oct;21(5):410-22
8632836
Arch Ophthalmol. 2000 Mar;118(3):378-84
10721961
J Comp Neurol. 1990 Nov 1;301(1):55-64
1706358
Ophthalmology. 2008 May;115(5):763-8
18452762
Arch Ophthalmol. 1982 Jan;100(1):135-46
7055464
Opt Lett. 1993 Nov 1;18(21):1864-6
19829430
Br J Ophthalmol. 2006 Jun;90(6):674-8
16464969
Brain Res. 1989 Nov 6;501(2):364-72
2819446
Neurosci Lett. 2007 Jun 13;420(2):97-9
17543991
Ann Neurol. 1993 Mar;33(3):248-57
8498808
Eur Neurol. 2002;47(3):165-8
11914555
Neurology. 2006 Nov 28;67(10):1852-4
17130422