[In vitro and in vivo effects of a long-acting anti-influenza agent CS-8958 (laninamivir octanoate, Inavir) against pandemic (H1N1) 2009 influenza viruses].
Laninamivir is a novel neuraminidase inhibitor of influenza viruses and it has been reported that its prodrug, CS-8958 shows a long-lasting characteristics. Using viruses isolated in Nagasaki of pandemic (H1N1) 2009 influenza virus which cause pandemic in 2009, it was shown that laninamivir has a strong inhibitory activities against their neuraminidases and virus replication in cultured cells, and strong binding stability to the virus NA. Furthermore, a single intranasal administration of CS-8958 showed a superior reduction of virus load in lungs in mouse infection model. These suggest that CS-8958 will work as a long-acting neuraminidase inhibitor to an infection with pandemic (H1N1) 2009 influenza viruses as well.
Daiichi Sankyo Co. Ltd., Biological Research Laboratories.
Shuku
S
Kubo
Masayo
M
Kakuta
Makoto
M
Yamashita
D000281:Administration, Intranasal; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D002478:Cells, Cultured; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004285:Dogs; D024882:Drug Resistance, Viral; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification / Q000502:physiology; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology*; D007564:Japan / Q000453:epidemiology; D008168:Lung / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D058873:Pandemics; D019562:Viral Load / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects; D053243:Zanamivir / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D000998:Antiviral Agents; C546919:CS 8958; D003692:Delayed-Action Preparations; D004791:Enzyme Inhibitors; D009439:Neuraminidase; D053243:Zanamivir