Age-specific prevalence of metabolic syndrome in Italian patients with bipolar disorder.
OBJECTIVE
Metabolic syndrome (MetS) is highly prevalent in patients with bipolar disorder (BD). Little research has evaluated the risk profile of MetS and cardiovascular disease in different gender and age groups in these patients. Our aim is to evaluate the prevalence of MetS in Italian patients with BD stratified by gender and age, and to determine the correlates of MetS.


METHODS
Subjects with BD were included and stratified by sex and age according to the following age groups: <30; 30-39; 40-49; 50-59; ≥ 60 years. Socio-demographic and clinical characteristics, lifestyle information, and comorbidity for cardiovascular diseases and diabetes were collected. MetS was diagnosed according to National Cholesterol Education Program Adult Treatment Panel III modified criteria.


RESULTS
MetS was evaluated in 200 patients, with a prevalence of 26.5%. Men had higher rates of hypertension and hypertriglyceridemia, women had more abdominal obesity. Women had a peak of prevalence in the ≥ 60 years group, while men displayed high rates even in the young age groups. In young patients, MetS was associated with Cluster B personality disorders and less physical exercise.


CONCLUSIONS
Our paper highlights the importance of evaluating MetS even in young patients with bipolar disorder, especially males. The strong association with lack of physical exercise suggests that the implementation of healthy behaviors might be relevant in order to prevent MetS and future adverse cardiovascular outcomes.
Mood and Anxiety Disorders Unit, Department of Neuroscience, University of Turin, Turin, Italy.
Virginio
V
Salvi
Virginia
V
D'Ambrosio
Gianluca
G
Rosso
Filippo
F
Bogetto
Giuseppe
G
Maina
D000328:Adult; D000367:Age Factors; D000368:Aged; D001714:Bipolar Disorder / Q000150:complications*; D002318:Cardiovascular Diseases / Q000150:complications / Q000523:psychology; D003920:Diabetes Mellitus / Q000523:psychology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000523:psychology; D015228:Hypertriglyceridemia / Q000150:complications / Q000523:psychology; D007558:Italy / Q000453:epidemiology; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000523:psychology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors