rDNA transcription and cardiac hypertrophy.
A common result of the various stimuli that alter the growth rates of cells is a parallel alteration of the rate of ribosome biogenesis. In many cell types, this mandates an altered rate of ribosomal RNA synthesis. Preliminary studies indicate that rDNA transcription may in fact be regulated at more than one level or step. Our understanding of the process of transcription and the mechanisms by which it is regulated are discussed.
Weis Center for Research, Geisinger Clinic, 100 North Academy Avenue, Danville, PA 17822-2618, USA.
W
W
Xie
L I
LI
Rothblum