[Obesity and female reproduction].
Weight, fat mass and obesity have been shown to play a major role in female reproduction. Obese women have a greater risk than nonobese women of infertility and they fail to become pregnant in both natural and assisted conception cycles. This cannot be explained only by their lack of ovulation. There are several potential mechanisms. On one hand, the endometrium seems to be partially responsible for this low fecundity in obese women. On the other hand, the oocyte seems to be implied. In a model of obese mouse, maternal obesity prior to conception is associated with altered mitochondria in mouse oocytes and an increased generation of reactive oxygen species (ROS). Furthermore, compared with controls, obese mice have significantly more decreased embryonic IGF-IR staining, smaller fetuses and smaller pups. In this model, all weaned pups have been fed with a regular diet. At 13 weeks, pups delivered from obese mice were significantly larger, and these pups demonstrated early development of a metabolic-type syndrome. These findings suggest that maternal obesity has adverse effects as early as the oocyte and preimplantation embryo stages and that these effects may contribute to lasting morbidity in offspring, underscoring the importance of optimal maternal weight and nutrition before conception.
Service d'Endocrinologie et des Maladies de la Reproduction, Centre Hospitalier Universitaire de Bicêtre - APHP, 78 rue du Général-Leclerc 94275 Le Kremlin-Bicêtre, France. sarfati_julie@yahoo.fr
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Sarfati
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Young
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Christin-Maitre
D000818:Animals; D004717:Endometrium / Q000378:metabolism; D005260:Female; D005298:Fertility; D005306:Fertilization; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism; D051379:Mice; D008820:Mice, Obese; D008928:Mitochondria / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D009865:Oocytes / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000378:metabolism
D017382:Reactive Oxygen Species; D017526:Receptor, IGF Type 1