Comparison of serological markers between ACPA⁺ and ACPA⁻ of RA patients.
Anti-citrullinated protein/peptide antibodies (ACPA) have recently emerged as sensitive and specific serological markers of rheumatoid arthritis (RA), providing superior alternative of the rheumatoid factor (RF) test in the laboratory diagnostics of RA. We compare the change of serum RF, CRP, IgG, IgM, IgA, total complement, C3 and C4. The sera sample was collected from 123 patients with RA. ACPA were detected with ELISA, and RF, CRP and total complement (Ct), C3 and C4 were examined by automatic biochemical analyzer. Serum RF and total complement concentrations were significantly higher in ACPA+ than in ACPA-, but there were no correlation between ACPA and RF and Ct. Between ACPA+ and ACPA-, there were no significant difference of CRP, IgG, IgM, IgA, total complement, C3 and C4. While there were significant correlation between the concentration of C3 and IgM and ACPA in ACPA+.


CONCLUSIONS
This is the first study to show that ACPA concentration in ACPA+ patients with RA is positively related to serum IgM and C3 levels.
Laboratory Department, The affiliated hospital of Jiu Jiang University, Jiujiang, 332000 Jiangxi, China. z6x2m@126.com
Chunhua
C
Xun
Yong
Y
Zhao
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002681:China; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D011379:Prognosis; D012217:Rheumatoid Factor / Q000097:blood; D055815:Young Adult
D001323:Autoantibodies; D015415:Biomarkers; D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D002097:C-Reactive Protein; D012217:Rheumatoid Factor
Arthritis Res. 2002;4 Suppl 2:S1-5
12110150
Arthritis Rheum. 2000 Jan;43(1):155-63
10643712
Autoimmun Rev. 2010 Apr;9(6):431-5
19932198
Rheumatology (Oxford). 2008 Oct;47(10):1489-92
18703528
QJM. 2010 Mar;103(3):139-46
19926660
Trends Immunol. 2009 Feb;30(2):83-90
19144569
Arthritis Rheum. 1988 Mar;31(3):315-24
3358796
Arthritis Rheum. 2006 Dec;54(12):3799-808
17133560
J Exp Med. 2009 Nov 23;206(12):2779-93
19858324
J Rheumatol. 2002 Oct;29(10):2074-6
12375314
J Clin Invest. 1998 Jan 1;101(1):273-81
9421490
Arthritis Rheum. 2002 Feb;46(2):357-65
11840437
Arthritis Rheum. 2008 Mar;58(3):678-88
18311806
Clin Rheumatol. 1987 Sep;6(3):350-7
3442962
Arthritis Res. 2002;4(2):87-93
11879544
Arthritis Rheum. 2009 Jul;60(7):1923-31
19565507
Ann Rheum Dis. 2004 Sep;63(9):1079-84
15308516
Neth J Med. 2002 Nov;60(10):383-8
12607587
Clin Rheum Dis. 1983 Apr;9(1):135-60
6347504
Autoimmun Rev. 2010 Jan;9(3):140-3
19427413
Arthritis Rheum. 2002 Apr;46(4):934-45
11953970
Am Clin Lab. 2002 Aug-Sep;21(7):34-6
12380030
Arthritis Rheum. 1991 Dec;34(12):1531-7
1747138
Scand J Rheumatol. 2003;32(4):197-204
14626625