Optofluidic tweezer on a chip.
A novel method to realize an optical tweezer involving optofluidic operation in a microchannel is proposed. To manipulate the optical tweezer, light from an optical fiber is passed through both PDMS (polydimethylsiloxane)-air surface lenses and an optofluidic region, which is located in a control channel. Two liquids with different refractive indices (RIs) are introduced into the control channel to form two different flow patterns (i.e., laminar and segmented flows), depending on the liquid compositions, the channel geometry, and the flow rates. By altering the shapes of the interface of the two liquids in the optofluidic region, we can continuously or intermittently control the optical paths of the light. To demonstrate the functionality of the proposed method, optical tweezer operations on a chip are performed. Changing the flow pattern of two liquids with different RIs in the optofluidic region results in successful trapping of a 25 μm diameter microsphere and its displacement by 15 μm.
K
K
Ono
S
S
Kaneda
T
T
Shiraishi
T
T
Fujii
Appl Opt. 1993 Aug 1;32(22):4181-6
20830064
Cytometry. 1991;12(6):505-10
1764975
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3191-6
18316742
Nat Mater. 2003 Nov;2(11):715-25
14593396
Opt Express. 2009 Aug 3;17(16):13624-38
19654770
Biophys J. 2001 Aug;81(2):767-84
11463624
Opt Express. 2006 Oct 30;14(22):10494-9
19529450
Opt Lett. 1986 May 1;11(5):288
19730608
Biophys J. 1992 Feb;61(2):569-82
19431818
Anal Chem. 2001 Apr 1;73(7):1622-6
11321319
Nature. 1992 Dec 3;360(6403):493-5
1448176
Lab Chip. 2007 Oct;7(10):1303-8
17896014
Annu Rev Biophys Biomol Struct. 2007;36:213-31
17269901
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12434-8
15314232
Opt Lett. 2006 Jan 1;31(1):59-61
16419877
Lab Chip. 2009 Apr 21;9(8):1040-2
19350083
Lab Chip. 2006 Aug;6(8):1040-4
16874375
Lab Chip. 2008 Mar;8(3):395-401
18305856
Opt Express. 2004 Nov 1;12(22):5440-7
19484104
Appl Opt. 1987 Dec 15;26(24):5311-6
20523522