A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives.
An easy one-pot tandem reaction catalyzed by a chiral secondary amine for the synthesis of optically active oxazine derivatives has been performed and the corresponding substituted benzo[d]pyrido[2,1-b][1,3]oxazine derivatives were afforded in generally high yields (up to 99%) and excellent enantioselectivities (up to >99%).
Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Zhichao
Z
Jin
Feng
F
Yu
Xiao
X
Wang
Huicai
H
Huang
Xiaoyan
X
Luo
Xinmiao
X
Liang
Jinxing
J
Ye
D002384:Catalysis; D008958:Models, Molecular; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D010078:Oxazines