Successful treatment of renal AA amyloidosis in familial Mediterranean fever with pegylated alpha-2a interferon.
Renal AA amyloidosis is a severe consequence of chronic inflammatory diseases such as familial Mediterranean fever (FMF). FMF is caused by mutations in the MEFV gene, resulting in defective control of granulocyte-mediated inflammation. Interferon-alpha is known to induce MEFV expression in monocytes and granulocytes in vitro. We present the first case of colchicine-resistant FMF in which a durable disease remission and regression of renal amyloidosis was induced by chronic treatment with pegylated interferon-alpha.
Department of 1Nephrology and Infectious Diseases and 2Pathology, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium. Stefaan.Vandecasteele@azbrugge.be
S J
SJ
Vandecasteele
P
P
De Paepe
A S
AS
De Vriese
D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D001706:Biopsy; D003078:Colchicine / Q000627:therapeutic use; D003598:Cytoskeletal Proteins / Q000235:genetics; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D009154:Mutation; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D000071198:Pyrin; D011994:Recombinant Proteins; D016896:Treatment Outcome
D003598:Cytoskeletal Proteins; D007155:Immunologic Factors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; C000604192:MEFV protein, human; D000071198:Pyrin; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a; D003078:Colchicine