Plexiform fibrohistiocytic tumor with molecular and cytogenetic analysis.
A child with plexiform fibrohistiocytic tumor is presented, in whom a superficial biopsy was misdiagnosed as an inflammatory granuloma. Cytogenetic analysis revealed a 46,X,del(X)(q13)[3]/46,XX[23] karyotype. However, fluorescence in situ hybridization (FISH) and array-comparative genomic hybridization (CGH) analysis failed to detect any numerical or quantitative genomic anomaly. Because of lack of specific chromosomal hallmarks, a molecular diagnosis of plexiform fibrohistiocytic tumor with the currently available tools is not reliable.
Departments of Pathology, Necker-Enfants Malades Hospital, APHP, Paris, France.
Stéphanie
S
Leclerc-Mercier
Florence
F
Pedeutour
Thibault
T
Fabas
Christophe
C
Glorion
Nicole
N
Brousse
Sylvie
S
Fraitag
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis / Q000378:metabolism; D002872:Chromosome Deletion; D020732:Cytogenetic Analysis / Q000379:methods; D003951:Diagnostic Errors; D005260:Female; D006099:Granuloma / Q000175:diagnosis; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D006801:Humans; D012680:Sensitivity and Specificity; D025064:Sex Chromosome Disorders / Q000235:genetics; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D016896:Treatment Outcome; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule