Pathogenetic and therapeutic implications of calcitonin-gene-related peptide in the cardiovascular system.
Calcitonin-gene-related peptide (CGRP) is one of the recently discovered endogenous peptides with potent cardiovascular effects in humans and in animals. Its powerful vasodilating action in addition to its direct positive inotropic effect on the heart, plus its presence in perivascular nerve endings in the heart and the latest demonstration of specific receptors in the human heart, suggest important physiologic and therapeutic roles for CGRP in cardiovascular diseases.
Clinical Pharmacology Unit, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.
S A
SA
Shawket
M J
MJ
Brown