Interaction of ACE and CYP11B2 genes on blood pressure response to hydrochlorothiazide in Han Chinese hypertensive patients.
To valuate whether angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and aldosterone synthase (CYP11B2) gene -344T/C polymorphism are associated with individual response to hydrochlorothiazide (HCTZ) in the Han Chinese population with essential hypertension. We enrolled 829 mild/moderate hypertensive patients and 12.5 mg of HCTZ was given daily. After 6 weeks, the results showed that the ACE I/D polymorphism, not the CYP11B2 -344T/C polymorphism, was associated with systolic blood pressure (SBP) response to HCTZ (P = 0.009) in the Han Chinese population with essential hypertension, with no interaction.
Department of Preventive Medicine, North China Coal Medical University, Tangshan, China.
Yun
Y
Li
Yong
Y
Zhou
Peng
P
Yang
Jian Qing
JQ
Niu
Ying
Y
Wu
Dan Dan
DD
Zhao
Shou Ling
SL
Wu
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004843:Epistasis, Genetic / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D054643:INDEL Mutation / Q000235:genetics; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D019405:Cytochrome P-450 CYP11B2; D007703:Peptidyl-Dipeptidase A