Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one.
In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, (1)H NMR, mass) and elemental analysis. The title compounds (N(1)-N(10)) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index activities. Results displayed that compound N(3) exhibited significant analgesic activity. Among the title compounds studied, N(2), N(3), and N(8) exhibited significant anti- inflammatory activity comparable to reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.
Department of Pharmaceutical Chemistry, Balaji Institute of Pharmacy, Laknepally (V), Narsampet (M), Warangal, Andhra Pradesh - 506 331, India.
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Nirmal
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Prakash
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Meenakshi
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Shanmugapandiyan
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