Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?
Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. vhuff@mdacc.tmc.edu
Vicki
V
Huff
D048868:Adaptor Proteins, Signal Transducing; D016162:Genes, Wilms Tumor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation; D009857:Oncogenes / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics; D009396:Wilms Tumor / Q000235:genetics* / Q000503:physiopathology
C517118:AMER1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D025521:Tumor Suppressor Proteins
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