Coup d'Etat: an orphan takes control.
Chicken ovalbumin upstream promoter transcription factors (COUP-TFs) belong to the steroid/thyroid hormone receptor superfamily. Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because ligands for COUP-TFs have yet to be identified. Since 1998, extensive studies have demonstrated their physiological importance in cell-fate specification, organogenesis, angiogenesis, and metabolism, as well as a variety of diseases. In this article, we will comprehensively review the biological functions of COUP-TFII and its underlying mechanism in various developmental processes and diseases. In addition, we will briefly summarize some of the current findings of COUP-TFI.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Texas 77030, USA. mtsai@bcm.edu
Fu-Jung
FJ
Lin
Jun
J
Qin
Ke
K
Tang
Sophia Y
SY
Tsai
Ming-Jer
MJ
Tsai
D000818:Animals; D051837:COUP Transcription Factor II / Q000235:genetics / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D008297:Male; D051379:Mice; D018919:Neovascularization, Physiologic / Q000502:physiology; D038081:Organogenesis / Q000502:physiology
D051837:COUP Transcription Factor II
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