C-reactive protein and glucose regulation in familial longevity.
Earlier, we showed that the offspring from exceptionally long-lived families have a more favorable glucose metabolism when compared with controls. As chronic low-grade inflammation has been regarded as a strong risk factor for insulin resistance, we evaluated if and to what extent the favorable glucose metabolism in offspring from long-lived families could be explained by differences in subclinical inflammation, as estimated from circulating levels of C-reactive protein. We found no difference between the two groups in C-reactive protein levels or in the distribution of C-reactive protein haplotypes. However, among controls higher levels of C-reactive protein were related to higher glucose levels, whereas among offspring levels of C-reactive protein were unrelated to glucose levels. It is a limitation of the current study that its cross-sectional nature does not allow for assessment of cause-effect relationships. One possible interpretation of these data is that the offspring from long-lived families might be able to regulate glucose levels more tightly under conditions of low-grade inflammation. To test this hypothesis, our future research will be focused on assessing the robustness of insulin sensitivity in response to various challenges in offspring from long-lived families and controls.
Department of Gerontology and Geriatrics, Leiden University Medical Center, the Netherlands.
Maarten P
MP
Rozing
Simon P
SP
Mooijaart
Marian
M
Beekman
Carolien A
CA
Wijsman
Andrea B
AB
Maier
Andrzej
A
Bartke
Rudi G J
RG
Westendorp
Eline P
EP
Slagboom
Diana
D
van Heemst
D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis* / Q000235:genetics; D005260:Female; D006239:Haplotypes; D006801:Humans; D007333:Insulin Resistance; D008136:Longevity / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
D001786:Blood Glucose; D002097:C-Reactive Protein
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