Efficient assembly of 1-(1H-imidazol-1-yl)-3-methylene-1H-indenes via tandem reaction of (2-(alkynyl)benzylidene)malonates with imidazoles.
The tandem nucleophilic addition and 5-exo-cyclization of (2-(alkynyl)benzylidene)malonates with imidazole derivatives in the presence of t-BuOK is reported. This reaction proceeds smoothly under mild conditions with high selectivity to afford the corresponding 1-(1H-imidazol-1-yl)-3-methylene-1H-indene-2,2(3H)-dicarboxylates in good to excellent yields.
Jiangxi Normal University, Nanchang, China.
Guanyinsheng
G
Qiu
Qiuping
Q
Ding
Ke
K
Gao
Yiyuan
Y
Peng
Jie
J
Wu
D007093:Imidazoles / Q000737:chemistry*; D007192:Indenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008314:Malonates / Q000737:chemistry*; D013058:Mass Spectrometry
D007093:Imidazoles; D007192:Indenes; D008314:Malonates; C030290:malonic acid