Long noncoding RNAs in cell biology.
Whole genome transcriptomic analyses have identified large numbers of dynamically expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose functions are, as yet, largely unknown. Here we summarize the growing evidence that lncRNAs, like mRNAs, can be trafficked to and function in a wide variety of subcellular locations. Investigation of the subcellular distribution of lncRNAs has the potential to greatly expand our knowledge not only of the function of lncRNAs but also of cell biology by identifying previously unknown subcellular structures and novel constituents of known cellular organelles.
Institute for Molecular Bioscience, University of Queensland, 306 Carmody Road, St Lucia, QLD 4072, Australia.
Michael B
MB
Clark
John S
JS
Mattick
D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism*
D022661:RNA, Untranslated