Pathomorphological study of the pancreas during phospholipase A2-induced experimental pancreatic necrosis.
The pathomorphogenesis of experimental acute pancreatic necrosis induced by administration of phospholipase A2 into the pancreatic tissue is characterized by pathomorphological signs of hemorrhagic pancreatic necrosis (total necrosis and purulent fusion of some acini and massive hemorrhages in the interlobular and intralobular interstitial tissue) and fatty pancreatic necrosis (necrobiotic and necrotic changes in acinar cells that spread from the peripheral area and form the demarcation line).
Department of General Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
L M
LM
Nepomnyashchikh
V G
VG
Viskunov
E L
EL
Lushnikova
S I
SI
Protsenko
D000818:Animals; D004386:Duodenum / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008853:Microscopy; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D019283:Pancreatitis, Acute Necrotizing / Q000473:pathology*; D054467:Phospholipases A2 / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism / Q000473:pathology
D054467:Phospholipases A2