Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population.
Large-scale population studies have established that genetic factors contribute to individual differences in smoking behavior. Linkage and genome-wide association studies have shown many chromosomal regions and genes associated with different smoking behaviors. One study was the association of single-nucleotide polymorphisms (SNPs) in the CHRNA5-A3-B4 gene cluster to nicotine addiction. Here, we report a replication of this association in the Italian population represented by three genetically isolated populations. One, the Val Borbera, is a genetic isolate from North-Western Italy; the Cilento population, is located in South-Western Italy; and the Carlantino village is located in South-Eastern Italy. Owing to their position and their isolation, the three populations have a different environment, different history and genetic structure. The variant A of the rs1051730 SNP was significantly associated with smoking quantity in two populations, Val Borbera and Cilento, no association was found in Carlantino population probably because difference in LD pattern in the variant region.
Institute of Genetics and Biophysics Adriano Buzzati-Traverso, CNR, Napoli, Italy.
Rossella
R
Sorice
Silvia
S
Bione
Serena
S
Sansanelli
Sheila
S
Ulivi
Emmanouil
E
Athanasakis
Carmela
C
Lanzara
Teresa
T
Nutile
Cinzia
C
Sala
Clara
C
Camaschella
Pio
P
D'Adamo
Paolo
P
Gasparini
Marina
M
Ciullo
Daniela
D
Toniolo
D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007558:Italy; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics*; D012907:Smoking / Q000235:genetics*; D014029:Tobacco Use Disorder / Q000235:genetics*
D009419:Nerve Tissue Proteins; D011978:Receptors, Nicotinic; C447158:CHRNA5 protein, human; C519072:CHRNB1 protein, human
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