Neurobiological and behavioral stress reactivity in children prenatally exposed to tobacco.
This study examined neurobiological and behavioral stress reactivity in children who had been prenatally exposed to tobacco. Neurobiological stress reactivity was measured using salivary cortisol and alpha-amylase levels at five different time points throughout a stressful neuropsychological test session, which involved a competition against a videotaped opponent. Participants (mean age: 10.6 years, SD 1.3) were 14 prenatally exposed (PE) children, 9 children with disruptive behavior problems (DBD), and 15 normal controls (NC). For cortisol responses, no significant differences between the three groups were observed. Normal controls, however, had significantly higher alpha-amylase levels than PE-children throughout the test session, and their alpha-amylase levels also increased throughout the session, whereas these remained low and stable for PE-children. Alpha-amylase levels and trajectory of PE-children were similar to those observed for DBD-children. PE-children also showed significantly increased behavioral stress reactivity compared to NC-children, and neurobiological and behavioral stress reactivity were inversely related in PE-children, again similar to what was observed for DBD-children. These results support the hypothesis that prenatal smoking may lead to long-lasting neurobiological and behavioral changes in exposed offspring.
Leiden University, Faculty of Social Sciences, Department of Clinical Child and Adolescent Studies, Leiden, The Netherlands. shuijbregts@fsw.leidenuniv.nl
Stephan C J
SC
Huijbregts
Sheila R
SR
van Berkel
Hanna
H
Swaab-Barneveld
Stephanie H M
SH
van Goozen
D000328:Adult; D000786:Anger; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000209:etiology / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis* / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012463:Saliva / Q000737:chemistry; D055291:Salivary alpha-Amylases / Q000032:analysis* / Q000378:metabolism; D013315:Stress, Psychological / Q000503:physiopathology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D014028:Tobacco Smoke Pollution; D055291:Salivary alpha-Amylases; D006854:Hydrocortisone