Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor.
Ten participants attending elective anterior segment eye surgery received 0.5% caspofungin eye drops either 1 drop hourly for 4 h or 1 drop an hour before surgery. The eye drops were generally well tolerated. In the absence of inflammation or corneal abrasion, topical caspofungin does not achieve clinically relevant concentrations.
Department of Pharmacy Practice, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Chin Fen
CF
Neoh
Lok
L
Leung
Anant
A
Misra
Rasik B
RB
Vajpayee
Geoffrey E
GE
Davies
Robert O
RO
Fullinfaw
Kay
K
Stewart
David C M
DC
Kong
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D000077336:Caspofungin; D054714:Echinocandins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D054714:Echinocandins; D055666:Lipopeptides; D009883:Ophthalmic Solutions; D000077336:Caspofungin
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