Antimicrobial evaluation of the polyisoprenylated benzophenones nemorosone and guttiferone A.
Polyisoprenylated benzophenones have been isolated from plants, particularly in the Clusiaceae family, and their biological properties recently have received considerable attention from a pharmacological point of view. The aim of the study was to investigate the polyisoprenylated benzophenones, nemorosone and guttiferone A, for their antimicrobial effect against a panel of bacteria, fungi and protozoan parasites. They showed a moderate activity against the Gram-positive bacterium Staphylococcus aureus, while no activity was demonstrated against Escherichia coli and the fungi Trichophyton rubrum and Candida albicans. An interesting activity was found for Plasmodium falciparum with IC₅₀ values lower than 1 μm, while cytotoxicity on MRC-5 cells revealed CC₅₀ values of 15.5 and 12.0 μm, respectively, for nemorosone and guttiferone A.
Department of Parasitology, Institute of Tropical Medicine 'Pedro Kouri', Havana City, Cuba.
L
L
Monzote
O
O
Cuesta-Rubio
A
A
Matheeussen
T
T
Van Assche
L
L
Maes
P
P
Cos
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002461:Cell Line, Transformed; D028084:Clusiaceae; D004926:Escherichia coli / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
D000890:Anti-Infective Agents; D001577:Benzophenones; C558133:guttiferone A; C437463:nemorosone