Alterations in corticolimbic dendritic morphology and emotional behavior in cannabinoid CB1 receptor-deficient mice parallel the effects of chronic stress.
Many changes produced by chronic stress are similar to those seen in cannabinoid CB(1) receptor-deficient mice. In the current study, we examined both anxiety-like behavior and dendritic complexity within the prefrontal cortex and basolateral amygdala (BLA) in wild-type and CB(1) receptor-deficient mice, under basal conditions and following exposure to 21 days of protracted restraint stress. CB(1) receptor-deficient mice exhibited increased indices of anxiety in the elevated plus maze under basal conditions that were similar in magnitude to changes seen in wild-type mice exposed to chronic stress. Chronic stress or deletion of the CB(1) receptor also produced a reduction in both apical dendritic length and branch points of neurons within layer II/III of the prelimbic region of the prefrontal cortex. Pyramidal neurons in the (BLA) of CB(1) receptor-deficient mice were found to have increased dendritic length compared with wild type. Chronic stress increased dendritic length of these amygdalar neurons in both wild-type and CB(1) receptor-deficient mice. Collectively, these data demonstrate that loss of cannabinoid CB(1) receptor signaling produces a chronic stress-like phenotype under basal conditions and provide a putative neural substrate that may subserve the changes in emotional behavior seen following disruption of CB(1) receptor signaling.
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA. mhill@rockefeller.edu
Matthew N
MN
Hill
Cecilia J
CJ
Hillard
Bruce S
BS
McEwen
D000679:Amygdala / Q000166:cytology / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology; D002908:Chronic Disease; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure*; D004644:Emotions / Q000502:physiology*; D008032:Limbic System / Q000502:physiology / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*
D043884:Receptor, Cannabinoid, CB1
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