Metal-mediated aggregation of DNA comprising 2,2'-bipyridine nucleoside, an asymmetrically substituted chiral bidentate ligand.
The incorporation of an artificial 5-methyl-2,2'-bipyridine nucleoside at the 5' terminus of an otherwise self-complementary oligonucleotide sequence opens up the opportunity of metal-mediated aggregation of DNA double helices triggered by the addition of the respective metal ions. Interestingly, two-dimensional aggregates (DNA monolayers) are formed in the presence of nickel(ii), whereas copper(ii) leads to the formation of three-dimensional disc-shaped structures. With iron(ii), a coexistence of both types of aggregates had been observed previously. Models are proposed in which these observations are explained based on geometrical considerations. The artificial nucleoside itself represents a rare example for a C(1)-symmetric chiral derivative of 2,2'-bipyridine, enabling the formation of four isomeric octahedral complexes.
Westfälische Wilhelms-Universität Münster, Institut für Anorganische und Analytische Chemie, Corrensstr 28/30, 48149 Münster, Germany. mueller.j@uni-muenster.de
Nicole
N
Megger
Lorena
L
Welte
Félix
F
Zamora
Jens
J
Müller
D015082:2,2'-Dipyridyl / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D009532:Nickel / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D013499:Surface Properties
D008024:Ligands; D009705:Nucleosides; D015082:2,2'-Dipyridyl; D003300:Copper; D009532:Nickel; D004247:DNA