Conformational effects induced by guest encapsulation in an enantiopure water-soluble cryptophane.
A new water-soluble cryptophane 1 derivative (penta-hydroxyl cryptophane-A) has been synthesized from cryptophanol-A and the chiroptical properties of its two enantiomers MM-1 and PP-1 have been studied by polarimetry, electronic circular dichroism (ECD), and vibrational circular dichroism (VCD). Cryptophane 1 shows specific circular dichroism responses upon complexation that depend on the size of the guest and on the nature of the counterion (Li(+), Na(+), K(+), Cs(+)) present in the solution. In LiOH and NaOH solutions, chiroptical changes induced by the encapsulation of guests and by the presence of cations in the vicinity of hosts can be interpreted from molecular dynamics (MD) and ab initio calculations by subtle conformational changes of the bridges. In KOH solution, the exchange dynamics is dependent on the size of the guest molecules, whereas in CsOH solution no encapsulation effect is observed whatever the size of the guest molecule. This last behavior comes from the fact that host 1 exhibits a very high affinity for cesium cations.
Institut des Sciences Moléculaires (UMR 5255-CNRS), Université Bordeaux 1, 351 Cours de la Libération, 33405 Talence, France.
Aude
A
Bouchet
Thierry
T
Brotin
Mathieu
M
Linares
Hans
H
Ågren
Dominique
D
Cavagnat
Thierry
T
Buffeteau
D002942:Circular Dichroism; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011789:Quantum Theory; D012995:Solubility; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
D011083:Polycyclic Compounds; C523242:cryptophane; D014867:Water