Plasma HDL-cholesterol and triglyceride levels in familial hypercholesterolemia: data from the MedPed CZ database and the Czech population.
BACKGROUND
The aim of this study was to compare HDL-cholesterol and triglyceride levels in patients with familial hypercholesterolemia (FH) with a representative sample of the Czech population.


METHODS
For the FH group: data of 1728 adult patients with FH (600 males and 1128 females) were taken from the MedPed CR database. The control group were 1995 individuals of the population sample of the Czech post-MONICA study (956 males and 1039 females).


RESULTS
Compared with controls, FH males showed higher levels of HDL-cholesterol (1.35±0.35 mmol/l vs. 1.31±0.35 mmol/l; P<0.05) and triglycerides (1.98±1.00 vs. 1.81±1.45 mmol/l; P<0.01). After adjustment for age and BMI, the increase in triglycerides remained significant in the subgroup of non-FDB males only (2.22±0.06 vs. 1.74±0.04 mmol/l; P<0.001). Compared with controls, HDL-cholesterol was lower (1.55±0.40 mmol/l vs. 1.65±0.37 mmol/l; P<0.001), while triglycerides were higher (1.72±0.82 mmol/l vs. 1.28±0.75, P<0.001) in FH females. After adjustment for age and BMI, HDL-cholesterol remained lower in the subgroup of FH females without FDB (1.52±0.01 vs. 1.67±0.01 mmol/l, P<0.001) whereas triglycerides were higher in both female subgroups.


CONCLUSIONS
A lower HDL-C in the group of FH patients compared with control subjects was demonstrated in FH females without FDB only. Elevated triglyceride levels were found in FH males and females, except for males with FDB.
Department of Clinical Biochemistry, St. Anne's University Hospital and 2nd Clinic of Internal Medicine, Masaryk University, Brno, Czech Republic.
Vladimír
V
Soska
Tomas
T
Freiberger
Renata
R
Cifkova
Vera
V
Lanska
Michal
M
Vrablik
Lenka
L
Fajkusova
Richard
R
Ceska
D000328:Adult; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D018153:Czech Republic; D016208:Databases, Factual; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D014280:Triglycerides