A functional Magnetic Resonance Imaging study of neurohemodynamic abnormalities during emotion processing in subjects at high risk for schizophrenia.
BACKGROUND
Emotion processing abnormalities are considered among the core deficits in schizophrenia. Subjects at high risk (HR) for schizophrenia also show these deficits. Structural neuroimaging studies examining unaffected relatives at high risk for schizophrenia have demonstrated neuroanatomical abnormalities involving neo-cortical and sub-cortical brain regions related to emotion processing. The brain functional correlates of emotion processing in these HR subjects in the context of ecologically valid, real-life dynamic images using functional Magnetic Resonance Imaging (fMRI) has not been examined previously.


OBJECTIVE
To examine the neurohemodynamic abnormalities during emotion processing in unaffected subjects at high risk for schizophrenia in comparison with age-, sex-, handedness- and education-matched healthy controls, using fMRI.


METHODS
HR subjects for schizophrenia (n=17) and matched healthy controls (n=16) were examined. The emotion processing of fearful facial expression was examined using a culturally appropriate and valid tool for Indian subjects. The fMRI was performed in a 1.5-T scanner during an implicit emotion processing paradigm. The fMRI analyses were performed using the Statistical Parametric Mapping 2 (SPM2) software.


RESULTS
HR subjects had significantly reduced brain activations in left insula, left medial frontal gyrus, left inferior frontal gyrus, right cingulate gyrus, right precentral gyrus and right inferior parietal lobule. Hypothesis-driven region-of-interest analysis revealed hypoactivation of right amygdala in HR subjects.


CONCLUSIONS
Study findings suggest that neurohemodynamic abnormalities involving limbic and frontal cortices could be potential indicators for increased vulnerability toward schizophrenia. The clinical utility of these novel findings in predicting the development of psychosis needs to be evaluated.
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, Karnataka, India.
Ganesan
G
Venkatasubramanian
Dawn Thomas K
DT
Puthumana
Peruvumba N
PN
Jayakumar
B N
BN
Gangadhar
Neuropsychologia. 2005;43(2):268-80
15707911
Neuroimage. 2002 Apr;15(4):870-8
11906227
JAMA. 1984 Oct 12;252(14):1905-7
6471323
Brain. 2003 Jul;126(Pt 7):1691-712
12805109
Br J Psychiatry. 1981 Jul;139:1-6
7296183
Neurosci Biobehav Rev. 2005 May;29(3):385-97
15820545
Br J Clin Psychol. 1989 Feb;28(1):19-29
2924024
Clin Psychol Rev. 2002 Jul;22(6):789-832
12214327
Br J Psychiatry. 2007 Aug;191:126-30
17666496
J Abnorm Psychol. 1996 Aug;105(3):480-3
8772021
J Cogn Neurosci. 2006 Jun;18(6):871-9
16839295
Am J Psychiatry. 2004 Oct;161(10):1806-13
15465977
J Cogn Neurosci. 2007 Aug;19(8):1354-72
17651008
Schizophr Res. 2004 Oct 1;70(2-3):241-61
15329301
Psychiatry Res. 1992 Jun;42(3):253-65
1496057
Nat Rev Neurosci. 2002 Mar;3(3):243-9
11994756
Nat Rev Neurosci. 2002 Feb;3(2):142-51
11836522
Prog Neuropsychopharmacol Biol Psychiatry. 2005 May;29(4):587-91
15866362
Br J Psychiatry. 2004 Aug;185:169-70
15286070
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
9881538
Schizophr Res. 1999 Nov 30;40(2):121-30
10593452
Psychophysiology. 2007 May;44(3):343-51
17433093
J Abnorm Psychol. 1993 May;102(2):312-8
8315144
Am J Psychiatry. 2005 Sep;162(9):1746-8
16135639
Q J Exp Psychol. 1967 Nov;19(4):327-33
6080917
Hum Brain Mapp. 2000 Jul;10(3):120-31
10912591
J Commun Disord. 1989 Apr;22(2):93-104
2723147
Can J Psychiatry. 2002 May;47(4):327-36
12025431
Cogn Neuropsychiatry. 2002 Aug;7(3):211-20
16571538
J Abnorm Psychol. 2000 Aug;109(3):512-6
11016120
Neuroimage. 1999 Jul;10(1):1-5
10385576
World Psychiatry. 2006 Jun;5(2):77-81
16946939
Can J Psychiatry. 2005 Aug;50(9):525-33
16262107
Yonsei Med J. 2006 Jun 30;47(3):343-53
16807983
Prog Neurobiol. 2005 Dec;77(5):283-98
16352388
Br J Psychiatry. 2005 Dec;187:523-8
16319404
Neuroimage. 2003 Jul;19(3):1233-9
12880848
Trends Cogn Sci. 2004 Sep;8(9):396-403
15350240
Schizophr Res. 2002 May 1;55(1-2):171-7
11955976
Neuroimage. 2003 Oct;20(2):1264-9
14568495
Lancet. 1999 Apr 24;353(9162):1425-30
10227239
Psychiatry. 1997 Winter;60(4):301-8
9460099
Schizophr Bull. 2003;29(3):487-97
14609242
Am J Psychiatry. 2005 Aug;162(8):1545
16055787
Philos Trans R Soc Lond B Biol Sci. 1996 Oct 29;351(1346):1433-43; discussion 1443-4
8941955
Schizophr Res. 1995 Sep;17(1):67-75
8541252
Neuropsychologia. 2007 Jan 7;45(1):174-94
16854439
Schizophr Bull. 1998;24(3):399-412
9718632