Comparative efficiency of succinate-containing antihypoxants in traumatic toxicosis.
Experiments on Wistar rats showed the development of endotoxicosis 12 h after severe compression injury. Endotoxicosis manifested in disorders in bromosulfaleine excretion from the blood, increase of blood urea, uric acid, creatinine, and potassium levels and aminotransferase activities. Injection of succinate-containing antihypoxants (reamberine, cytoflavin, metaprot plus, succinamic acid 2-amino-4-acetylthiasolo[5,4-b]indole) directly after decompression promoted recovery of liver function, prevented the development of hyperfermentemia and renal failure as a result of reduced blood levels of potassium and non-protein nitrogen. The protective effect of the drugs in traumatic toxicosisdecreased in the following order: metaprot plus>cytoflavin>2-amino-4-acetylthiasolo[5,4-b]indole succinaminic acid>reamberine.
Department of Pharmacology, S M Kirov Military Medical Academy, St. Petersburg, Russia. i.v.zarubina@inbox.ru
I V
IV
Zarubina
I A
IA
Yunusov
V V
VV
Marysheva
P D
PD
Shabanov
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004338:Drug Combinations; D019446:Endotoxemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D007511:Ischemia / Q000150:complications*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009536:Niacinamide / Q000627:therapeutic use*; D009584:Nitrogen / Q000097:blood; D011188:Potassium / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; C549374:Reamberin; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D008536:Meglumine; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D009584:Nitrogen; D011188:Potassium