Intralesional triamcinolone acetonide injection versus incision and curettage for primary chalazia: a prospective, randomized study.
OBJECTIVE
To compare treatment outcomes of intralesional triamcinolone acetonide (TA) injection with incision and curettage (I&C) for primary chalazia.


METHODS
Prospective, randomized clinical trial.


METHODS



METHODS
Institutional.


METHODS
Ninety-four patients with primary chalazia after failed conservative treatment were randomized to either intralesional TA injection (4 mg) or I&C performed under local anesthesia. All patients underwent comprehensive eye examinations that included digital photography of the lesion. Complete resolution was defined as lesion regression of 95% to 100%. Treatment was considered a failure if no resolution was achieved after the first attempted I&C or TA injection.


METHODS
Lesion resolution measured as 95% to 100% regression.


RESULTS
Ninety-four patients participated in the study: 42 underwent I&C and 52 underwent TA injection as the first treatment. Complete resolution was achieved in 33 (79%) of 42 patients in the I&C group and in 42 (81%) of 52 patients in the TA group (P=.8, chi-square analysis). The average time to resolution in the TA group was 5 days, with most patients (48/52; 92%) having received a single injection and 4 (8%) of 52 patients having received 2 injections. TA precipitates were detected in 6 (11.5%) of 52 patients and resolved spontaneously. There were no complications, such as eyelid depigmentation, increased intraocular pressure, or any loss of vision, in either group.


CONCLUSIONS
Intralesional TA injection is as effective as I&C in primary chalazia. Injection may be considered as an alternative first-line treatment in cases where diagnosis is straightforward and no biopsy is required.
Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel. guybensimon@gmail.com
Guy J
GJ
Ben Simon
Nachum
N
Rosen
Mordechai
M
Rosner
Abraham
A
Spierer
D000328:Adult; D017043:Chalazion / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D003475:Curettage; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D011446:Prospective Studies; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014792:Visual Acuity / Q000502:physiology
D005938:Glucocorticoids; D014222:Triamcinolone Acetonide