Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.
Affective disorders, which include anxiety and depression, are highly prevalent and have overwhelming emotional and physical symptoms. Despite human brain imaging studies, which have implicated the prefrontal cortex including the anterior cingulate cortex (ACC), little is known about the ACC in anxiety disorders. Here we show that the ACC does modulate anxiety-like behavior in adult mice, and have identified a protein that is critical for this modulation. Absence of neurabin, a cytoskeletal protein, resulted in reduced anxiety-like behavior and increased depression-like behavior. Selective inhibition of neurabin in the ACC reproduced the anxiety but not the depression phenotype. Furthermore, loss of neurabin increased the presynaptic release of glutamate and cingulate neuronal excitability. These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders.
Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada.
Susan S
SS
Kim
Hansen
H
Wang
Xiang-Yao
XY
Li
Tao
T
Chen
Valentina
V
Mercaldo
Giannina
G
Descalzi
Long-Jun
LJ
Wu
Min
M
Zhuo
D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001008:Anxiety Disorders / Q000188:drug therapy / Q000503:physiopathology*; D001522:Behavior, Animal; D002478:Cells, Cultured; D003866:Depressive Disorder / Q000503:physiopathology; D018757:GABA Modulators / Q000494:pharmacology; D055785:Gene Knockdown Techniques; D006179:Gyrus Cinguli / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008845:Microinjections; D008874:Midazolam / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D009483:Neuropsychological Tests; D018408:Patch-Clamp Techniques; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D009435:Synaptic Transmission / Q000502:physiology; D000099273:Neurabins
D018757:GABA Modulators; D008840:Microfilament Proteins; D008874:Midazolam; D009419:Nerve Tissue Proteins; D034741:RNA, Small Interfering; D017367:Selective Serotonin Reuptake Inhibitors; D000099273:Neurabins
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