Resveratrol modulates astroglial functions: neuroprotective hypothesis.
Resveratrol, a redox active compound present in grapes and wine, has a wide range of biological effects, including cardioprotective, chemopreventive, and anti-inflammatory activities. The central nervous system is a target of resveratrol, which can pass the blood-brain barrier and induce neuroprotective effects. Astrocytes are one of the most functionally diverse groups of cells in the nervous system, intimately associated with glutamatergic metabolism, transmission, synaptic plasticity, and neuroprotection. In this review, we focus on the resveratrol properties and response to oxidative insult on important astroglial parameters involved in brain plasticity, such as glutamate uptake, glutamine synthetase activity, glutathione content, and secretion of the trophic factor S100B.
Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
André
A
Quincozes-Santos
Carmem
C
Gottfried
D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D018696:Neuroprotective Agents / Q000378:metabolism / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D000077185:Resveratrol; D013267:Stilbenes / Q000378:metabolism / Q000494:pharmacology
D018696:Neuroprotective Agents; D013267:Stilbenes; D018698:Glutamic Acid; D000077185:Resveratrol