3D GRASE PROPELLER: improved image acquisition technique for arterial spin labeling perfusion imaging.
Arterial spin labeling is a noninvasive technique that can quantitatively measure cerebral blood flow. While traditionally arterial spin labeling employs 2D echo planar imaging or spiral acquisition trajectories, single-shot 3D gradient echo and spin echo (GRASE) is gaining popularity in arterial spin labeling due to inherent signal-to-noise ratio advantage and spatial coverage. However, a major limitation of 3D GRASE is through-plane blurring caused by T(2) decay. A novel technique combining 3D GRASE and a periodically rotated overlapping parallel lines with enhanced reconstruction trajectory (PROPELLER) is presented to minimize through-plane blurring without sacrificing perfusion sensitivity or increasing total scan time. Full brain perfusion images were acquired at a 3 × 3 × 5 mm(3) nominal voxel size with pulsed arterial spin labeling preparation sequence. Data from five healthy subjects was acquired on a GE 1.5T scanner in less than 4 minutes per subject. While showing good agreement in cerebral blood flow quantification with 3D gradient echo and spin echo, 3D GRASE PROPELLER demonstrated reduced through-plane blurring, improved anatomical details, high repeatability and robustness against motion, making it suitable for routine clinical use.
Virginia-Tech Wake Forest School of Biomedical Engineering and Sciences, Winston-Salem, North Carolina, USA. tanhuan@gmail.com
Huan
H
Tan
W Scott
WS
Hoge
Craig A
CA
Hamilton
Matthias
M
Günther
Robert A
RA
Kraft
D002560:Cerebrovascular Circulation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D012015:Reference Standards; D015203:Reproducibility of Results; D013113:Spin Labels
D013113:Spin Labels
Magn Reson Imaging. 1998;16(1):87-90
9436952
Magn Reson Med. 2006 Feb;55(2):380-5
16402378
Magn Reson Med. 1999 Nov;42(5):963-9
10542356
Magn Reson Med. 2003 Mar;49(3):515-26
12594755
Magn Reson Med. 2009 Jul;62(1):174-82
19365858
Magn Reson Med. 1999 Jun;41(6):1246-54
10371458
Magn Reson Med. 2005 Nov;54(5):1232-40
16206142
Magn Reson Med. 1998 Sep;40(3):383-96
9727941
J Cereb Blood Flow Metab. 1999 Jul;19(7):701-35
10413026
Lancet. 1986 Feb 8;1(8476):307-10
2868172
Magn Reson Med. 2010 Dec;64(6):1781-91
20665898
Magn Reson Med. 2004 Jul;52(1):131-40
15236376
IEEE Trans Med Imaging. 1991;10(3):473-8
18222850
Magn Reson Med. 1995 Sep;34(3):293-301
7500865
Magn Reson Med. 2000 Jul;44(1):92-100
10893526
Magn Reson Med. 2005 Sep;54(3):732-7
16086314
Magn Reson Imaging Clin N Am. 2009 May;17(2):315-38
19406361
Magn Reson Med. 2005 Aug;54(2):491-8
16032686