Revaccination of children after completion of standard chemotherapy for acute lymphoblastic leukaemia: a pilot study comparing different schedules.
Given that a significant proportion of children with acute lymphoblastic leukaemia (ALL) lose immune protection to tetanus, diphtheria, and poliomyelitis, revaccination is indicated after chemotherapy. Our randomized pilot study comparing different revaccination schedules suggests that children with ALL might be revaccinated with non-live vaccines as early as 3 months after chemotherapy.
Paediatric Haematology and Oncology University of Frankfurt, Germany. thomas.lehrnbecher@kgu.de
Thomas
T
Lehrnbecher
Ralf
R
Schubert
Regina
R
Allwinn
Kader
K
Dogan
Ulrike
U
Koehl
Hans-Peter
HP
Grüttner
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000914:Antibodies, Viral / Q000096:biosynthesis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D016667:Bacterial Capsules / Q000008:administration & dosage / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000276:immunology; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007115:Immunization Schedule; D007117:Immunization, Secondary / Q000379:methods*; D007136:Immunoglobulins / Q000097:blood; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D008297:Male; D010865:Pilot Projects; D023321:Poliovirus Vaccines / Q000008:administration & dosage / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000276:immunology*; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage* / Q000276:immunology; D055815:Young Adult
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D004168:Diphtheria Toxoid; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D007136:Immunoglobulins; D023321:Poliovirus Vaccines; D013745:Tetanus Toxoid; D015164:Vaccines, Inactivated