Association of apolipoprotein A5 gene promoter region -1131T>C with risk of stroke in Han Chinese.
BACKGROUND
Ischemic stroke is a suddenly developing temporary or often permanent damage of the brain. Several candidate genes have been shown to have an impact in the pathogenesis of ischemic stroke. Recently, the -1131T>C polymorphism in apolipoprotein A5 (APOA5) gene has been reported to be associated with ischemic stroke in different racial groups, but no data is available currently in Han Chinese. Our study is to investigate the association between the APOA5 gene polymorphism -1131T>C and the susceptibility to ischemic stroke in Han Chinese.


METHODS
310 controls and 342 patients with classified ischemic stroke were performed to detect the -1131T>C alleles genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in independent case-control study.


RESULTS
TG levels of subjects carrying -1131C allele were elevated compared to the subjects with -1131T allele in all ischemic stroke subgroups and in controls. The serum TC, LDL-C and HDL-C levels did not differ between subjects with T or C alleles in each group. The overall distribution of APOA5 -1131T>C genotype among stroke patients and controls was significantly different (P<0.01). Frequencies of CC homozygote and C allele were significantly higher in all stroke subgroups than those in control group. After adjustment for conventional risk factors, logistic regression analysis showed that C allele carrier (CC+CT) of -1131T>C was an independent risk factor for all stroke subgroups (P<0.05).


CONCLUSIONS
APOA5 gene -1131T>C polymorphism is independently associated with the development of ischemic stroke in Chinese Han population, and CC homozygote may have a promoting effect on ischemic stroke.
Department of Neurology, The General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China. chaodong11@yahoo.cn
XiaoQiu
X
Li
DongFeng
D
Su
XiaoLin
X
Zhang
ChaoDong
C
Zhang
D000368:Aged; D000465:Algorithms; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D005819:Genetic Markers