Using living cells to transport therapeutic genes for cancer treatment.
One of the key problems in cancer gene therapy is the inefficient delivery of therapeutic transgenes to tumour sites, after the systemic injection of the viral vector. Hence, new vector discovery is extremely important for the improvement of gene therapy results. Previously, mammalian cells were proposed as new vector systems; however with recent advances in stem cell research this modality makes them more suitable candidates. Tumours are composed of both malignant and benign cells. As "benign" cell types are able to form blood vessels, and stroma, it has been hypothesised that exogenously administrated cells of a different kind would preferentially engraft at the stromal tumour site and could deliver cancer gene therapy vectors to tumours.
Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain.
Camino
C
Latorre-Romero
Margarita R
MR
Marin-Yaseli
Carolina
C
Belmar-Lopez
Raquel
R
del Moral
Pedro C
PC
Marijuan
Miguel
M
Quintanilla
Pilar
P
Martin-Duque
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods / Q000706:statistics & numerical data*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy*; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology
Br J Haematol. 2007 Jun;137(6):491-502
17539772
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7413-7
2823261
Int J Oncol. 2001 Oct;19(4):681-5
11562741
Methods. 2004 Jun;33(2):151-63
15121170
Cancer Res. 2009 Dec 1;69(23):8932-40
19920199
Biol Blood Marrow Transplant. 2007 Apr;13(4):373-85
17382245
Cancer Res. 2010 Apr 15;70(8):3027-33
20395199
Immunity. 2008 Sep 19;29(3):372-83
18799145
N Engl J Med. 1994 Mar 24;330(12):827-38
8114836
N Engl J Med. 1975 Apr 17;292(16):832-43
234595
Anticancer Agents Med Chem. 2010 Feb;10(2):121-30
20184546
Hum Pathol. 2001 Apr;32(4):401-9
11331957
Blood. 2009 Oct 22;114(17):3546-56
19652199
Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S247-56
9917644
Cancer Gene Ther. 2010 Apr;17(4):289-97
19876078
Exp Hematol. 2006 Nov;34(11):1596-601
17046581
Blood. 2006 Dec 1;108(12):3938-44
16896152
Exp Hematol. 2000 Apr;28(4):382-90
10781896
Gene Ther. 2008 May;15(10):704-10
18356816
Bone Marrow Transplant. 2006 Mar;37(5):439-49
16444286
Rheumatology (Oxford). 2006 Oct;45(10):1187-93
16777856
Blood. 2000 Jan 15;95(2):700-4
10627482
Stem Cell Rev. 2005;1(1):53-9
17132875
Histol Histopathol. 1998 Jan;13(1):231-42
9476652
Stem Cells. 2007 Nov;25(11):2739-49
17656645
Stem Cells Dev. 2010 May;19(5):693-706
20067407
J Cell Mol Med. 2008 Dec;12(6B):2552-65
19210755
J Virol. 1997 Nov;71(11):8798-807
9343240
Gene Ther. 2000 Feb;7(4):314-20
10694812
Biochim Biophys Acta. 2008 Apr;1785(2):217-31
18328829
Semin Hematol. 2010 Jan;47(1):46-50
20109611
Mol Ther. 2003 Mar;7(3):354-65
12668131
Cancer Res. 2007 Dec 15;67(24):11687-95
18089798
Br J Cancer. 1999 Nov;81(6):1009-16
10576658
Exp Hematol. 2002 Aug;30(8):896-904
12160841
Differentiation. 2009 Sep-Oct;78(2-3):159-68
19604622
Clin Cancer Res. 2010 Jul 1;16(13):3399-408
20570924
Mol Cancer Res. 2008 Dec;6(12):1819-29
19074827
Cancer Res. 2002 Jul 1;62(13):3603-8
12097260
Cell. 2002 Apr 5;109(1):17-27
11955443
Blood. 2002 Feb 1;99(3):759-67
11806975
Curr Stem Cell Res Ther. 2010 Dec;5(4):372-8
20528759
Thorax. 2010 Apr;65(4):362-9
20388765
Nat Med. 2000 Nov;6(11):1282-6
11062543
Methods Mol Biol. 2010;636:55-78
20336516
Mol Cancer Ther. 2003 Nov;2(11):1233-42
14617797
J Proteome Res. 2009 Jun;8(6):2873-81
19351187
Science. 1999 Apr 2;284(5411):143-7
10102814
Gene Ther. 2006 Aug;13(15):1131-2
17243201
Stem Cells. 2008 Mar;26(3):831-41
18192232
Transl Res. 2010 Sep;156(3):147-54
20801411
Lancet. 2003 Feb 15;361(9357):553-60
12598139
Blood. 2001 Mar 15;97(6):1598-603
11238097
Nat Med. 1999 Mar;5(3):309-13
10086387
Stem Cells. 2009 Apr;27(4):857-65
19350687
Gene Ther. 2001 Jan;8(2):89-98
11313778
J Gen Virol. 2000 Nov;81(Pt 11):2605-2609
11038370
Transplantation. 2003 Mar 15;75(5):679-85
12640309
Science. 1995 Oct 20;270(5235):475-80
7570001
Science. 1995 Oct 20;270(5235):470-5
7570000