The relationship between urinary 8-hydroxydeoxyguanosine and metabolic risk factors in asymptomatic subjects.
OBJECTIVE
The aim of this study was to investigate the relationship between metabolic risk factors and oxidative stress using urinary 8-hydroxydeoxyguanosine (8-OHdG), a recently utilized biological marker, in asymptomatic subjects.


METHODS
Ninety subjects (males/females = 30/60; mean age = 52 years), who were nonsmoking, nondiabetic and not on any medicine, were enrolled in the study. The body mass index, blood pressure, total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and glucose as well as urinary 8-OHdG and creatinine were measured.


RESULTS
The median level of 8-OHdG was 9.3 ng/mg creatinine (interquartile range: 5.8-23.2). TG (Pearson's correlation: r = 0.262, p = 0.013) and HDL-C (r = -0.259, p = 0.014) showed a significant correlation with 8-OHdG. A multiple linear regression analysis adjusted for all the variables revealed that only TG had an independently significant and positive correlation with 8-OHdG (β = 0.231, p = 0.046).


CONCLUSIONS
The data in this population suggest that, among metabolic risk factors, hypertriglyceridemia may be weakly but significantly associated with hyperoxidative stress as assessed by 8-OHdG.
Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke, Japan.
Michiaki
M
Miyamoto
Kazuhiko
K
Kotani
Shun
S
Ishibashi
Nobuyuki
N
Taniguchi
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000378:metabolism*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D018384:Oxidative Stress; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000378:metabolism*
D008076:Cholesterol, HDL; D014280:Triglycerides; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine