Lignans and other constituents from the roots of the Vietnamese medicinal plant Pseuderanthemum palatiferum.
Two new lignans, palatiferin A (1) and palatiferin B (2), were isolated from the roots of Pseuderanthemum palatiferum, together with five known triterpenes, epifriedelanol (3), lupeol (4), lupenone (5), betulin (6), pomolic acid (7), and a dipeptide asperglaucide (8). Their structures were established from 2D NMR and mass spectroscopy. The absolute configuration of 1 and 2 was proposed based on the comparison of their optical rotation activities with those of compounds with similar structures such as wodeshiol and paulownin. The new lignans, palatiferin A (1) and palatiferin B (2) exhibited a moderate cytotoxicity against KB and HepG2 cell lines. However, betulin and lupeol, two abundant compounds from the roots of P. palatiferum, showed cytotoxic and antimicrobial activities.
Institute of Marine Biochemistry-VAST, Hanoi, Vietnam. dtmhuong@ich.vast.ac.vn
Huong Doan  Thi
HD
Mai
Hang Nguyen Thi
HN
Minh
Van Cuong
VC
Pham
Kim Nga
KN
Bui
Van Hung
VH
Nguyen
Van Minh
VM
Chau
D027901:Acanthaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008518:Medicine, East Asian Traditional; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000094062:Betulinic Acid; D000094042:Lupanes
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C576251:palatiferin A; C576252:palatiferin B; C002503:betulin; D000094062:Betulinic Acid; C010480:lupeol; D000094042:Lupanes