A cytogenetic study of couples with repeated spontaneous abortions.
OBJECTIVE
The frequency of chromosomal aberrations in Iran is not definitely known. This study determined the frequency of chromosomal aberrations in a series of couples with two or more spontaneous abortions and compared the findings with that reported from other countries.


METHODS
This was a descriptive study conducted on 100 couples with recurrent abortions. Both partners were karyotyped as part of the primary investigation. Other probable causes of abortion were also investigated.


RESULTS
Chromosomal aberrations were found in 8 (8%) of the females and 5 (5%) of the males. The prevalence of chromosomal abnormalities was as follows: 4 (30.8%) balanced reciprocal translocations, 3 (23%) Robertsonian translocations, 3 (23%) pericentric inversions, 1 (7.7%) paracentric inversion, 1 (7.7%) chromosomal marker, and 1 (7.7%) polymorphism 9qh+.


CONCLUSIONS
The pattern of chromosomal aberrations was similar to that reported in other studies, but the prevalence of chromosomal aberrations was higher.
Mirza Koochak Khan Hospital, Medical Sciences/University of Tehran, Tehran, Iran.
Shirin
S
Niroumanesh
Parvin
P
Mehdipour
Ali
A
Farajpour
Soodabeh
S
Darvish
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D007446:Chromosome Inversion; D003582:Cytogenetics; D005220:Fathers; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007492:Iran; D007621:Karyotyping; D008297:Male; D009035:Mothers; D011110:Polymorphism, Genetic; D014178:Translocation, Genetic; D055815:Young Adult
D005819:Genetic Markers
Ann Saudi Med. 2000 May-July;20(3-4):233-6
17322664
Am J Med Genet. 2001 Oct 1;103(2):160-2
11568924
Eur J Obstet Gynecol Reprod Biol. 2006 Jul;127(1):106-9
16443317
Fertil Steril. 2007 Sep;88(3):721-3
17320875
Hum Reprod. 1990 Jul;5(5):519-28
2203803
Fertil Steril. 2004 May;81(5):1296-301
15136093
Semin Reprod Med. 2000;18(4):433-40
11355802
Fertil Steril. 2006 Dec;86(6):1792-5
17056042