Exploring decision-making of HIV-infected Hispanics and African Americans participating in clinical trials.
Underrepresentation of HIV-infected Hispanics and African Americans in clinical trials seriously limits our understanding of the benefits and risks of treatment in these populations. This qualitative study examined factors that racial/ethnic minority patients consider when making decisions regarding research participation. A total of 35 HIV-infected Hispanic and African American patients enrolled in clinical research protocols at the National Institutes of Health were recruited to participate in focus groups and in-depth interviews. The sample included mostly male participants (n = 22), had a mean age of 45, had nearly equal representation of race/ethnicity, and were diagnosed 2 to 22 years earlier. Baseline questionnaires included demographics and measures of social support and acculturation. Interviewers had similar racial/ethnic, cultural, and linguistic backgrounds as the participants. Four major themes related to the decisions of participants to enroll in clinical trials emerged, which are as follows: enhancers, barriers, beliefs, and psychosocial context. Results may help researchers develop strategies to facilitate inclusion of HIV-infected Hispanics and African Americans into clinical trials.
Migdalia V
MV
Rivera-Goba
Dinora C
DC
Dominguez
Pamela
P
Stoll
Christine
C
Grady
Catalina
C
Ramos
JoAnn M
JM
Mican
D000328:Adult; D001741:Black or African American / Q000523:psychology*; D002986:Clinical Trials as Topic; D003657:Decision Making; D005260:Female; D017144:Focus Groups; D015658:HIV Infections / Q000523:psychology*; D006630:Hispanic or Latino / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012935:Social Justice; D014481:United States
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