Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2.
Streptococcus suis serotype 2 (S. suis 2) is a pathogen responsible for several diseases in both pigs and humans. To gain more insight into the pathogenesis of this organism, an oligonucleotide (oligo)-based microarray was used to investigate gene expression changes in human monocytic cells (THP-1) in response to exposure to S. suis 2 strain SC19. A total of 328 differentially expressed genes were identified. These differentially expressed genes belonged to a variety of functional categories, including genes involved in apoptosis, immunity, signal transduction, chemokine production and the ubiquitin-proteasome system. Our findings can be of interest for future research.
Division of Animal Pathogens, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, PR China.
Manli
M
Liu
Chen
C
Tan
Liurong
L
Fang
Shaobo
S
Xiao
Huanchun
H
Chen
D002460:Cell Line / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D009000:Monocytes / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D020411:Oligonucleotide Array Sequence Analysis; D060888:Real-Time Polymerase Chain Reaction; D013290:Streptococcal Infections / Q000235:genetics* / Q000276:immunology; D017011:Streptococcus suis / Q000472:pathogenicity*; D059467:Transcriptome