Bacteremia caused by Corynebacterium amycolatum with a novel mutation in gyrA gene that confers high-level quinolone resistance.
Although Corynebacterium amycolatum can cause opportunistic infections, it is commonly considered as contaminant. In this report, we present a case of bacteremia caused by C. amycolatum with a novel mutation in the gyrA gene that confers high-level quinolone resistance to the organism.
Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
Seoyoung
S
Yoon
Heejung
H
Kim
Yangsoon
Y
Lee
Sinyoung
S
Kim
D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D003352:Corynebacterium / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D003354:Corynebacterium Infections / Q000175:diagnosis* / Q000188:drug therapy; D027081:DNA Gyrase / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009154:Mutation; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D014640:Vancomycin; D027081:DNA Gyrase
Antimicrob Agents Chemother. 1995 Jan;39(1):208-14
7695308
Clin Microbiol Rev. 1997 Jan;10(1):125-59
8993861
Int J Antimicrob Agents. 2007 Jun;29(6):688-92
17475450
Antimicrob Agents Chemother. 2005 May;49(5):1714-9
15855486
J Clin Microbiol. 1994 Feb;32(2):335-51
7512093