Vaccine-related varicella-zoster rash in a hospitalized immunocompetent patient.
An immunocompetent health care worker with no known history of varicella-zoster virus (VZV) disease was exposed to a patient with herpes zoster and was immunized 2 days later. Twenty-seven days after receiving the varicella vaccine, while hospitalized, she developed a disseminated rash. This exposure and subsequent development of symptoms posed infection control challenges. A polymerase chain reaction analysis of her vesicular fluid was positive for vaccine-type VZV, and a blood specimen collected before vaccination demonstrated a positive VZV titer by the fluorescent antibody to membrane antigen test. To the best of our knowledge, there have been no previous reports of an immunocompetent seropositive person developing vaccine-type VZV after receiving the vaccine.
Department of Infection Prevention and Control, New York Presbyterian Hospital, NY 10032, USA. pab9053@nyp.org
Paul
P
Bernstein
Yoko
Y
Furuya
Sharon
S
Steinberg
Brian
B
Scully
Philip
P
Larussa
Anne A
AA
Gershon
D000914:Antibodies, Viral / Q000097:blood; D002644:Chickenpox / Q000175:diagnosis* / Q000473:pathology; D019433:Chickenpox Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D005076:Exanthema / Q000473:pathology; D005260:Female; D006282:Health Personnel; D014645:Herpesvirus 3, Human / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure; D056990:Post-Exposure Prophylaxis / Q000379:methods
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine
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