Changes in bone marrow and peripheral compartments of the erythron under the effect of tumor cells in indolent non-Hodgkin lymphomas and multiple myeloma.
Here we present the results of pathomorphological study of erythron cells from patients with indolent non-Hodgkin lymphomas and multiple myeloma. The revealed associations suggest that tumor cells can modulate the bone marrow and peripheral compartment of the erythron in lymphoproliferative diseases leading to quantitative and morphological changes in bone marrow erythrokaryocytes and peripheral blood erythrocytes. Clinical and pathomorphological markers of dyshemopoiesis associated with the presence of anemia were identified in indolent non-Hodgkin lymphomas. In multiple myeloma, a correlation between the parameters of bone marrow and peripheral compartments of the erythron and structural modifications of myeloma cells infiltrating the bone marrow was revealed.
Laboratory of Molecular, Cellular, and Immunomorphological Bases of Oncohematology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
E E
EE
Petrusenko
N P
NP
Domnikova
G I
GI
Nepomnyashchikh
N A
NA
Mal'tseva
D000368:Aged; D000704:Analysis of Variance; D001853:Bone Marrow / Q000473:pathology*; D003584:Cytological Techniques; D041905:Erythroid Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*