Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi Metallo-β-lactamase.
Carbapenem resistance in Klebsiella pneumoniae is most notably due to the K. pneumoniae carbapenemase (KPC) β-lactamase. In this report, we describe the occurrence of a newly described mechanism of carbapenem resistance, the NDM-1 β-lactamase, in a patient who received medical attention (but was not hospitalized) in India.
University of Queensland Centre for Clinical Research, Queensland, Australia.
Hanna
H
Sidjabat
Graeme R
GR
Nimmo
Timothy R
TR
Walsh
Enzo
E
Binotto
Anthony
A
Htin
Yoshiro
Y
Hayashi
Jian
J
Li
Roger L
RL
Nation
Narelle
N
George
David L
DL
Paterson
D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001315:Australia; D015373:Bacterial Typing Techniques; D015780:Carbapenems / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007194:India; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D014552:Urinary Tract Infections / Q000382:microbiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1
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