Anti-inflammatory flavonolignans from Hydnocarpus anthelminthica seeds.
A new flavonolignan, anthelminthicol A (1), together with four known compounds, was isolated from the EtOAc extracts of the seeds of Hydnocarpus anthelminthica. Their structures were elucidated using extensive spectroscopic techniques. Bioassay showed that compounds 3-5 could inhibit nitric oxide production in LPS-stimulated RAW 264.7 macrophage cell lines, with IC(50) values of 7.81, 9.38, and 10.55 μM, respectively.
College of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
Jun-Feng
JF
Wang
Ge-Fen
GF
Yin
Xiao-Jiang
XJ
Zhou
Jia
J
Su
Yan
Y
Li
Hui-Min
HM
Zhong
Gang
G
Duan
Yong-Xian
YX
Cheng
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044947:Flavonolignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D031308:Salicaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D044947:Flavonolignans; D008070:Lipopolysaccharides; C556043:anthelminthicol A; D009569:Nitric Oxide; D015232:Dinoprostone