Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients.
Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ+45 T/G and +276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and 102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established by PCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differences between CRC patients and control group (p= 0.01 for G/A genotype and p= 0.02 for the recessive model G/G +G/A); yet, in the analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shown any significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients.
Instituto de Genética Humana, CUCS, U de G. Sierra Mojada no. 950, Guadalajara, Jalisco, México.
Miriam
M
Partida-Pérez
María
M
de la Luz Ayala-Madrigal
Jorge
J
Peregrina-Sandoval
Nelly
N
Macías-Gómez
José
J
Moreno-Ortiz
Evelia
E
Leal-Ugarte
Mario
M
Cárdenas-Meza
Manuel
M
Centeno-Flores
Víctor
V
Maciel-Gutiérrez
Enrique
E
Cabrales
Sergio
S
Cervantes-Ortiz
Melva
M
Gutiérrez-Angulo
D052242:Adiponectin / Q000235:genetics; D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D020738:Leptin / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000502:physiology; D020641:Polymorphism, Single Nucleotide
C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin