Class 1 integron in staphylococci.
As a major concern in public health, methicillin-resistant staphylococci (MRS) still remains one of the most prevalent pathogens that cause nosocomial infections throughout the world and has been recently labeled as a "super bug" in antibiotic resistance. Thus, surveillance and investigation on antibiotic resistance mechanisms involved in clinical MRS strains may raise urgent necessity and utmost significance. As a novel antibiotic resistance mechanism, class 1 integron has been identified as a primary source of antimicrobial resistance genes in Gram-negative organisms. However, most available studies on integrons had been limited within Gram-negative microbes, little is known for clinical Gram-positive bacteria. Based on series studies of systematic integrons investigation in hundreds of staphylococci strains during 2001-2006, this review concentrated on the latest development of class 1 integron in MRS isolates, including summary of prevalence and occurrence of class 1 integron, analysis of correlation between integron and antibiotic resistance, further demonstration of the role integrons play as antibiotic determinants, as well as origin and evolution of integron-associated gene cassettes during this study period.
College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China.
Zhenbo
Z
Xu
Lin
L
Li
Lei
L
Shi
Mark E
ME
Shirtliff
D019143:Evolution, Molecular; D006801:Humans; D032023:Integrons / Q000235:genetics*; D016106:Methicillin Resistance / Q000235:genetics; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013210:Staphylococcus / Q000235:genetics* / Q000302:isolation & purification
J Clin Microbiol. 1999 Nov;37(11):3556-63
10523551
Diagn Microbiol Infect Dis. 2010 Nov;68(3):315-7
20846812
Mol Microbiol. 1989 Dec;3(12):1669-83
2560119
Mol Microbiol. 1998 Jul;29(2):477-90
9720866
Emerg Infect Dis. 2001 Sep-Oct;7(5):862-71
11747700
Diagn Microbiol Infect Dis. 1997 Jun;28(2):53-9
9239494
FEMS Microbiol Lett. 2006 Jan;254(1):75-80
16451182
J Clin Microbiol. 2001 Jan;39(1):8-13
11136740
BMC Genomics. 2008 May 31;9:261
18513439
Clin Microbiol Infect. 2004 Apr;10(4):272-88
15059115
Antimicrob Agents Chemother. 2000 Jun;44(6):1568-74
10817710
Microb Drug Resist. 2001 Fall;7(3):263-72
11759088
Clin Microbiol Infect. 2006 Mar;12 Suppl 1:3-8
16445718
FEMS Microbiol Lett. 2001 Feb 5;195(1):59-65
11166996
Mol Microbiol. 1993 Jul;9(1):41-52
8412670
FEMS Microbiol Lett. 2008 Jan;278(2):223-30
18096018
J Antimicrob Chemother. 2005 Mar;55(3):371-4
15705645
J Bacteriol. 1994 Oct;176(20):6286-94
7929000
J Clin Microbiol. 2000 Mar;38(3):1008-15
10698988
Clin Microbiol Infect. 1999 Jun;5(6):308-318
11856275
Curr Opin Microbiol. 2001 Oct;4(5):565-9
11587934
J Clin Microbiol. 2003 Jun;41(6):2444-7
12791862
J Clin Microbiol. 2000 Sep;38(9):3453-6
10970402
Microb Drug Resist. 1995 Fall;1(3):195-202
9158775
J Clin Microbiol. 2007 Jan;45(1):241-3
17122024
J Bacteriol. 2002 Mar;184(6):1712-21
11872723
J Bacteriol. 1999 Nov;181(21):6844-9
10542191
Clin Microbiol Infect. 2011 May;17(5):714-8
21521411
Antimicrob Agents Chemother. 2002 May;46(5):1402-9
11959575
Eur J Clin Microbiol Infect Dis. 1999 Nov;18(11):761-70
10614949
Antimicrob Agents Chemother. 1996 Jun;40(6):1534-5
8726033
J Clin Microbiol. 2003 Dec;41(12):5429-33
14662921
Antimicrob Agents Chemother. 1999 Oct;43(10):2538-41
10508040
J Clin Microbiol. 2000 Mar;38(3):1032-5
10698991
Antimicrob Agents Chemother. 2005 Dec;49(12):5179-81
16304199
Mol Microbiol. 1997 Nov;26(4):731-45
9427403
Microbiol Immunol. 1998;42(11):739-43
9886146
Curr Microbiol. 2008 Sep;57(3):264-8
18594909
J Antimicrob Chemother. 2007 Apr;59(4):746-50
17307772
Antimicrob Agents Chemother. 2004 Mar;48(3):838-42
14982773
Science. 1998 Apr 24;280(5363):605-8
9554855
Res Microbiol. 1999 Nov-Dec;150(9-10):641-51
10673003
Microbiol Immunol. 2006;50(6):463-7
16785718
Emerg Infect Dis. 2001 Mar-Apr;7(2):178-82
11294701
Antimicrob Agents Chemother. 2001 Apr;45(4):1022-9
11257011
Plasmid. 2002 Sep;48(2):117-29
12383729
Drug Resist Updat. 1998;1(2):109-19
16904397
Clin Microbiol Infect. 2002 Jun;8(6):321-31
12084099
Antimicrob Agents Chemother. 2000 Jun;44(6):1549-55
10817707
Mol Biol Rep. 2010 Jun;37(5):2183-8
19685165
J Appl Microbiol. 2002;92(5):992-1004
11972706
APMIS Suppl. 1998;84:37-42
9850680
Microbiology (Reading). 1995 Dec;141 ( Pt 12):3015-27
8574395
Ann N Y Acad Sci. 1999 May 18;870:68-80
10415474
Antimicrob Agents Chemother. 1999 Jan;43(1):157-60
9869582
J Clin Microbiol. 1998 Sep;36(9):2696-702
9705416
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):652-7
11209061
Antimicrob Agents Chemother. 2001 May;45(5):1323-36
11302791
J Antimicrob Chemother. 1998 Dec;42(6):689-96
10052890
J Clin Microbiol. 1996 Dec;34(12):2909-13
8940421
Emerg Infect Dis. 2003 Aug;9(8):978-84
12967497
Mol Microbiol. 1995 Feb;15(4):593-600
7783631
Lancet. 2001 Apr 21;357(9264):1225-40
11418146
Clin Microbiol Infect. 2007 Oct;13(10):980-4
17803751
Microbiol Mol Biol Rev. 1999 Sep;63(3):507-22
10477306
J Clin Microbiol. 2009 Jan;47(1):230-4
19020065
Trends Microbiol. 2007 Jul;15(7):301-9
17566739
Nat Rev Microbiol. 2006 Aug;4(8):608-20
16845431
Antimicrob Agents Chemother. 2002 Jul;46(7):2155-61
12069968
Proc Natl Acad Sci U S A. 2004 May 4;101(18):7118-22
15107498
Lancet. 2002 Mar 2;359(9308):753-9
11888586
JAMA. 2003 Dec 10;290(22):2976-84
14665659
J Clin Microbiol. 2002 Apr;40(4):1538-40
11923391
J Bacteriol. 1991 May;173(9):3025-8
1850404
Microbiology (Reading). 2000 Oct;146 ( Pt 10):2605-2612
11021935
J Med Microbiol. 2001 Jul;50(7):636-641
11444774
Microb Drug Resist. 1998 Summer;4(2):113-8
9650997
Antimicrob Agents Chemother. 2004 Jan;48(1):285-96
14693553
Antimicrob Agents Chemother. 1998 Aug;42(8):2074-83
9687410
Antimicrob Agents Chemother. 1993 Apr;37(4):761-8
8494372
MMWR Morb Mortal Wkly Rep. 2003 Aug 22;52(33):793-5
12931079
Nature. 2000 Aug 3;406(6795):477-83
10952301
Antimicrob Agents Chemother. 2005 Oct;49(10):4418-20
16189138
Trends Microbiol. 1997 Oct;5(10):389-94
9351174
Antimicrob Agents Chemother. 1999 Mar;43(3):693-6
10049292
J Bacteriol. 1994 Sep;176(17):5450-8
8071223
Lancet Infect Dis. 2005 May;5(5):275-86
15854883
Nature. 1990 Jun 21;345(6277):739-43
2163027
J Clin Microbiol. 2005 Jul;43(7):3364-72
16000461
Antimicrob Agents Chemother. 1995 Jan;39(1):155-62
7695299
J Clin Microbiol. 2004 Aug;42(8):3483-9
15297487
FEMS Microbiol Lett. 1998 Dec 15;169(2):391-5
9868786
J Clin Microbiol. 1995 Jun;33(6):1537-47
7650182
Antimicrob Agents Chemother. 2003 Sep;47(9):2838-43
12936982
Int J Antimicrob Agents. 1997 Mar;8(2):109-14
18611790
Microb Drug Resist. 2000 Summer;6(2):91-8
10990262
Genetica. 1993;90(2-3):115-32
8119588
Emerg Infect Dis. 2002 Jun;8(6):602-7
12023917
Antimicrob Agents Chemother. 1995 Jul;39(7):1612-5
7492116
J Antimicrob Chemother. 2000 Apr;45(4):467-73
10747823