A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates.
α-Isocyanoacetamides, acyl chlorides and dialkylacetylenedicarboxylates undergo a smooth multicomponent reaction to produce dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates in good yield. The scope and mechanism of this new multicomponent transformation are discussed.
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale A. Avogadro, Via Bovio 6, 28100, Novara, Italy.
Riccardo
R
Mossetti
Diego
D
Caprioglio
Giampiero
G
Colombano
Gian Cesare
GC
Tron
Tracey
T
Pirali
D000215:Acylation; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
D000588:Amines; D002264:Carboxylic Acids; D005663:Furans; D009570:Nitriles; C039281:furan; C031594:2-cyanoacetamide