Excision of extensive metastatic dysgerminoma to control refractory hypercalcaemia in a child at high risk for tumour-lysis syndrome.
Hypercalcaemia is a rare life-threatening complication of paediatric cancer that is commoner in haematological than solid malignancies and associated rarely with acute renal failure. Often refractory to medical therapy, control of hypercalcaemia in children with solid tumours may necessitate excision of localised tumours or urgent chemotherapy for metastatic ones. We present a child with refractory hypercalcaemia, bulky chemosensitive metastatic tumours and acute renal failure in whom chemotherapy posed high-risk of tumour lysis syndrome (TLS). Resection of the metastatic tumours successfully normalised the hypercalcaemia and represents a practical alternative control strategy in cases at high risk of TLS.
Division of Child Health, University of Liverpool, Liverpool L12 2AP, UK.
Wajid
W
Jawaid
Valeria
V
Solari
Lisa
L
Howell
Edwin
E
Jesudason
D058186:Acute Kidney Injury / Q000453:epidemiology; D002648:Child; D004407:Dysgerminoma / Q000453:epidemiology / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000517:prevention & control*; D012307:Risk Factors; D015275:Tumor Lysis Syndrome / Q000209:etiology / Q000517:prevention & control*