Serotonin: imaging findings in eating disorders.
Anorexia nervosa (AN) and bulimia nervosa (BN) are disorders characterized by aberrant patterns of feeding behavior, weight regulation, and disturbances in attitudes and perceptions toward body weight and shape. Several lines of evidence nominate disturbances of serotonin (5-HT) pathways as playing a role in the pathogenesis and pathophysiology of AN and BN. For example, 5-HT pathways are known to contribute to the modulation of a range of behaviors commonly seen in individuals with AN and BN. New technology using brain imaging with radioligands offers the potential for understanding previously inaccessible brain 5-HT neurotransmitter function and its dynamic relationship with human behaviors. Recent studies using positron emission tomography and single photon emission computed tomography with 5-HT-specific radioligands have consistently shown 5-HT(1A) and 5-HT(2A) receptor and 5-HT transporter alterations in AN and BN in cortical and limbic structures, which may be related to anxiety, behavioral inhibition, and body image distortions. These disturbances are present when subjects are ill and persist after recovery, suggesting that these may be traits that are independent of the state of the illness. Effective treatments for AN and BN have been elusive. A better understanding of neurobiology is likely to be important for developing specific and more powerful therapies for these often chronic and deadly disorders.
Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, Austria.
Ursula F
UF
Bailer
Walter H
WH
Kaye
D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001068:Feeding and Eating Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D059906:Neuroimaging; D049268:Positron-Emission Tomography; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon
D044402:Receptor, Serotonin, 5-HT2A; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin
J Clin Psychopharmacol. 1998 Dec;18(6):447-54
9864076
Br J Psychiatry. 2008 Sep;193(3):229-34
18757983
Arch Gen Psychiatry. 1998 Jul;55(7):603-10
9672050
Br J Psychiatry. 1998 Apr;172:351-8
9715339
Biol Psychiatry. 1999 Jun 15;45(12):1542-52
10376114
Biol Psychiatry. 1998 Nov 1;44(9):825-38
9807638
Neuropsychopharmacology. 2001 Apr;24(4):370-8
11182532
Neurochem Int. 1997 Jun;30(6):565-74
9152998
Am J Psychiatry. 1995 Jan;152(1):64-71
7802123
Cereb Cortex. 2004 Mar;14(3):281-99
14754868
Metabolism. 1986 Oct;35(10):938-43
3531760
Ann Neurol. 1981 Oct;10(4):309-25
7032417
Brain Res. 1995 Aug 7;688(1-2):121-33
8542298
Prog Neurobiol. 2009 May;88(1):17-31
19428959
Arch Gen Psychiatry. 1987 Jun;44(6):573-88
3579504
Am J Psychiatry. 2001 Jul;158(7):1152-5
11431241
Nat Neurosci. 2006 Nov;9(11):1362-3
17013380
Arch Gen Psychiatry. 1984 Apr;41(4):350-5
6200083
Arch Gen Psychiatry. 1998 Oct;55(10):927-35
9783564
Am J Psychiatry. 1991 Sep;148(9):1206-12
1882999
Behav Brain Res. 1996;73(1-2):37-42
8788474
Biol Psychiatry. 2002 Nov 1;52(9):896-906
12399143
Neuropsychopharmacology. 1999 Aug;21(2 Suppl):99S-105S
10432495
Crit Rev Neurobiol. 1996;10(3-4):419-46
8978989
Biol Psychiatry. 2004 Apr 15;55(8):871-3
15050870
Ann N Y Acad Sci. 2004 Jun;1018:58-64
15240352
Am J Psychiatry. 1991 Dec;148(12):1627-37
1842216
Arch Gen Psychiatry. 1992 Feb;49(2):132-8
1372494
Psychol Bull. 2002 Sep;128(5):825-48
12206196
Biol Psychiatry. 2001 Apr 1;49(7):644-52
11297722
Arch Gen Psychiatry. 1995 May;52(5):374-83
7726718
Neuropsychopharmacology. 2005 Apr;30(4):669-82
15688093
Cereb Cortex. 2004 Oct;14(10):1100-9
15115744
J Child Psychol Psychiatry. 2005 Dec;46(12):1317-26
16313432
Neuropsychopharmacology. 2003 Jun;28(6):1045-55
12700686
Acta Psychiatr Scand. 1997 Aug;96(2):101-7
9272193
Ann N Y Acad Sci. 1995 Dec 15;769:213-39
8595027
Int J Eat Disord. 1995 Apr;17(3):291-7
7773266
Psychol Med. 1990 Nov;20(4):785-91
2284387
Neuropsychopharmacology. 2005 May;30(5):1028-32
15841087
Arch Gen Psychiatry. 2005 Sep;62(9):1032-41
16143735
Am J Psychiatry. 2004 Dec;161(12):2215-21
15569892
Curr Drug Targets. 2006 Feb;7(2):149-58
16475956
Neuroreport. 2003 Dec 2;14(17):2193-7
14625446
Neuropharmacology. 2003 Jul;45(1):72-81
12814660
Psychol Med. 1996 Mar;26(2):353-9
8685291
Neuropsychopharmacology. 2004 Jun;29(6):1143-55
15054474
Am J Psychiatry. 2004 Oct;161(10):1916-8
15465993
Psychoneuroendocrinology. 1995;20(6):561-90
8584599
Biol Psychiatry. 2007 May 1;61(9):1081-9
16979141
Int Clin Psychopharmacol. 1992 Jun;6 Suppl 4:5-13
1431011
Nucl Med Biol. 2007 Oct;34(7):865-77
17921037
Int J Eat Disord. 2005;37 Suppl:S60-3; discussion S87-9
15852322
Eur Psychiatry. 2000 Feb;15(1):38-45
10713801
Science. 1972 Oct 27;178(4059):414-6
5077329
Biol Psychiatry. 2008 Dec 1;64(11):1009-13
18639866
Behav Pharmacol. 2001 Nov;12(6-7):439-50
11742137
Pharmacol Biochem Behav. 2000 May;66(1):65-72
10837844
J Neurosci. 2004 Jan 21;24(3):589-91
14736842
Neurosci Biobehav Rev. 2000 May;24(3):341-53
10781694
Psychol Med. 2001 Jan;31(1):85-95
11200963
Int J Eat Disord. 2002 Nov;32(3):253-70
12210640
Am J Psychiatry. 2005 May;162(5):915-23
15863793
J Clin Psychiatry. 1991 Dec;52 Suppl:41-8
1752859
JAMA. 2006 Jun 14;295(22):2605-12
16772623
J Clin Psychiatry. 1991 Oct;52 Suppl:34-8
1938987
Neuropharmacology. 1984 Dec;23(12B):1537-51
6152027
J Nucl Med. 2003 Feb;44(2):163-9
12571204
Behav Brain Res. 1996;73(1-2):31-5
8788473
Psychopharmacol Bull. 1990;26(3):393-405
2274641
Ann N Y Acad Sci. 1997 Dec 29;836:220-32
9616801
J Nerv Ment Dis. 2000 Sep;188(9):559-67
11009328
J Psychiatry Neurosci. 2007 Sep;32(5):354-62
17823651
J Nerv Ment Dis. 1995 Sep;183(9):593-8
7561822
Compr Psychiatry. 1993 Jul-Aug;34(4):249-53
8348803
Biol Psychiatry. 2005 Mar 15;57(6):674-8
15780856
Biol Psychiatry. 1988 Jan 1;23(1):102-5
2447961
Biol Psychiatry. 2001 Feb 15;49(4):326-32
11239903
Appetite. 1986;7 Suppl:1-14
2874768
Int J Eat Disord. 2005 Jan;37(1):57-60
15690467
Ann N Y Acad Sci. 1990;600:532-44
2252333
J Clin Psychiatry. 1992 Apr;53 Suppl:17-28
1532961
Nucl Med Biol. 2000 Jul;27(5):429-35
10962246
J Clin Psychiatry. 1996;57 Suppl 8:11-6
8698675
J Clin Psychiatry. 1991 Nov;52(11):464-71
1744064
Int J Eat Disord. 2007 Nov;40 Suppl:S52-60
17573683
Int J Eat Disord. 2003 Apr;33(3):257-67; discussion 268-70
12655621
Psychol Med. 1996 Jan;26(1):15-28
8643754
Nat Rev Neurosci. 2009 Aug;10(8):573-84
19603056
Physiol Behav. 2004 Aug;82(1):97-107
15234597
Psychol Med. 1994 Feb;24(1):3-8
8208892
Int J Eat Disord. 2006 May;39(4):276-84
16528697
J Psychiatr Res. 2007 Dec;41(12):1005-11
17054991
Am J Psychiatry. 2003 Feb;160(2):242-7
12562569
Arch Gen Psychiatry. 1991 Jun;48(6):556-62
1710099
Brain. 1995 Feb;118 ( Pt 1):279-306
7895011
Arch Gen Psychiatry. 2006 Mar;63(3):305-12
16520436
Physiol Behav. 2005 May 19;85(1):73-81
15869768
Psychiatry Res. 2001 Aug 5;103(1):15-26
11472787
Int J Eat Disord. 2011 Sep;44(6):477-87
20872754
Psychopharmacology (Berl). 2001 May;155(3):310-4
11432694
Neuropharmacology. 2000 Apr 3;39(6):1037-43
10727714
Behav Pharmacol. 2003 Sep;14(5-6):369-83
14501251
J Neuropsychiatry Clin Neurosci. 1993 Winter;5(1):9-17
7679020
Neuropsychopharmacology. 2009 Sep;34(10):2275-84
19458612
Int J Eat Disord. 1997 Dec;22(4):339-60
9356884
Int J Eat Disord. 1993 Sep;14(2):213-8
8401554
Neurochem Int. 1994 Dec;25(6):503-32
7894328
Biol Psychiatry. 1998 Oct 1;44(7):534-49
9787877
J Neural Transm Gen Sect. 1991;85(3):181-94
1834090
Clin Psychol Rev. 2006 May;26(3):299-320
16330138
Biol Psychiatry. 2007 Feb 1;61(3):348-58
16815322
J Abnorm Psychol. 1994 Feb;103(1):137-47
8040475
Psychopharmacology (Berl). 2000 Mar;148(4):344-9
10928305
Psychopharmacology (Berl). 1998 Nov;140(1):69-74
9862404
Psychopharmacology (Berl). 2007 Dec;195(3):315-24
17690869
Arch Gen Psychiatry. 1992 Feb;49(2):139-47
1550466
Annu Rev Med. 2000;51:465-79
10774477
Neuropsychobiology. 1986;15(2):89-94
3762904
BMC Psychiatry. 2007 May 21;7:19
17511889
Arch Gen Psychiatry. 2001 Sep;58(9):837-43
11545666
Ann N Y Acad Sci. 1996 Mar 22;780:213-22
8602735
Am J Psychiatry. 2000 Mar;157(3):393-401
10698815
Neuroscience. 1999;93(4):1271-87
10501451
Int J Eat Disord. 1998 Sep;24(2):115-24
9697010
Neuropsychopharmacology. 1999 May;20(5):424-33
10192823
Biol Psychiatry. 2007 May 1;61(9):1090-9
17241616
J Neurol Neurosurg Psychiatry. 1981 Apr;44(4):323-8
6165809
Biol Psychiatry. 1990 Jan 1;27(1):4-21
2297551
Psychosom Med. 2000 Jul-Aug;62(4):535-8
10949099
Neuropsychopharmacology. 1999 Aug;21(2 Suppl):91S-98S
10432494
Am J Psychiatry. 2002 Jan;159(1):96-102
11772696