Keratin 15-positive stem cells give rise to basal cell carcinomas in irradiated Ptch1(+/-) mice.
The cell of origin for basal cell carcinoma (BCC) remains controversial. In this issue of Cancer Cell, Wang et al. provide strong evidence that BCC arise from hair follicle stem cells.
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
John T
JT
Seykora
George
G
Cotsarelis
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3438-43
10725363
Nat Cell Biol. 2010 Mar;12(3):299-305
20154679
Nat Biotechnol. 2004 Apr;22(4):411-7
15024388
Cell. 1990 Jun 29;61(7):1329-37
2364430
Science. 1997 May 2;276(5313):817-21
9115210
Nat Med. 2005 Dec;11(12):1351-4
16288281
J Cutan Pathol. 1999 Mar;26(3):113-8
10235375
Nat Genet. 2000 Mar;24(3):216-7
10700170
EMBO J. 2003 Jun 2;22(11):2741-51
12773389
J Cell Sci. 1998 Nov;111 ( Pt 21):3179-88
9763512