A straightforward and efficient synthetic access to biologically active marine sesterterpenoids, sesterstatins 4 and 5.
A straightforward and efficient synthesis of sesterstatins 4 and 5 is reported, in which the reductive Heck cyclisation was employed as the key step for constructing the D ring.
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Wen-Yuan
WY
Fan
Zheng-Lin
ZL
Wang
Hong-Chang
HC
Li
John S
JS
Fossey
Wei-Ping
WP
Deng
D059001:Aquatic Organisms / Q000737:chemistry*; D003500:Cyclization; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry; D019427:HIV Integrase / Q000378:metabolism; D019429:Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
D003603:Cytotoxins; D019429:Integrase Inhibitors; D013729:Terpenes; C116699:sesterstatin 4; C116700:sesterstatin 5; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1