Leukocyte adhesion molecules and myocardial ischemia.
Current evidence strongly indicates that neutrophils contribute to the injury seen after ischemia and reperfusion of various tissues. Potentially important therapeutic targets are the specific adhesion mechanisms supporting neutrophil extravasation and secretory activity. Several such mechanisms have been characterized recently at a molecular level in vitro, and warrant investigation in relevant models of human disease.
Speros P. Martel Leukocyte Biology Laboratory, Department of Pediatrics, The Methodist Hospital, Baylor College of Medicine, Houston, TX 77054, USA.
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Smith
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Anderson
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Taylor
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Rossen
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Entman