The impact of hyperuricemia on in-hospital mortality and incidence of acute kidney injury in patients undergoing percutaneous coronary intervention.
BACKGROUND
There is very little information about the relationship between hyperuricemia, acute kidney injury (AKI) and in-hospital mortality.


RESULTS
With a retrospective analysis of the medical records, 1,247 patients who had percutaneous coronary intervention (PCI) were investigated. AKI was defined as an increase in serum creatinine of ≥0.5mg/dl or ≥50% over baseline within 7 days of PCI. The association of AKI with clinical, biochemical and procedural variables were examined. In addition, the association of hyperuricemia with in-hospital mortality was also examined. Of the 1,247 patients in the study population, 51 (4.1%) experienced AKI after PCI, 15 of whom required hemodialysis. In-hospital mortality occurred in 1.6% (20 of 1,247) in 19.6% (10 of 51) of AKI individuals, and 0.8% (10 of 1,186) of the non-AKI participants (odd ratios, 28.927; 95% confidence intervals, 11.411-73.328; P<0.001). In our study, the most powerful predictors of these variables were acute myocardial infarction, baseline estimated glomerular filtration rate (eGFR) <60 ml·min(-1)·1.73 m(-2), diabetics mellitus, anemia and hyperuricemia. Notably, the incidence of AKI after PCI markedly increased in diabetic or hyperuricemic patients with a baseline eGFR of <60 ml·min(-1)·1.73 m(-2).


CONCLUSIONS
It is clear that AKI develops due to multiple risk factors. Our results indicate that hyperuricemia is independently associated with an increased risk of in-hospital mortality and AKI in patients treated with PCI.
Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
Sang-Ho
SH
Park
Won-Yong
WY
Shin
Eun-Young
EY
Lee
Hyo-Wook
HW
Gil
Se-Whan
SW
Lee
Seung-Jin
SJ
Lee
Dong-Kyu
DK
Jin
Sae-Yong
SY
Hong
D058186:Acute Kidney Injury / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications / Q000150:complications; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D017052:Hospital Mortality; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000150:complications*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D003404:Creatinine