Electrophilic carbocyclization of aryl propargylic alcohols: a facile synthesis of diiodinated carbocycles and heterocycles.
Diiodinated carbocycles and oxygen heterocycles can be readily synthesized by electrophilic carbocyclization of aryl propargylic alcohols in moderate to good yields under mild conditions. The resulting diiodide can be further exploited by subsequent oxidizing and coupling reactions. Both the iodine anion and cation generated from I(2) are used effectively. The presence of a trace amount of water is essential for this electrophilic cyclization.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China.
Hai-Tao
HT
Zhu
Ke-Gong
KG
Ji
Fang
F
Yang
Li-Jing
LJ
Wang
Shu-Chun
SC
Zhao
Shaukat
S
Ali
Xue-Yuan
XY
Liu
Yong-Min
YM
Liang