Some aspects of toxicological activity of kardosten after chronic 6-month administration to rats.
Chronic treatment of rats with kardosten for 6 months had a positive effect on some ECG values and behavior without disordering the hepatorenal functions. All effects of the drug observed during a course of treatment were leveled and the parameters reached the basal values within 2 weeks after drug discontinuation, this confirming its safety.
Department of Pharmacology, S M Kirov Military Medical Academy, St. Petersburg, Russia.
V I
VI
Petrov
L I
LI
Bugaeva
S A
SA
Lebedeva
E V
EV
Lavrova
Yu L
YL
Dugina
I A
IA
Kheifets
Yu A
YA
Zabolotneva
S A
SA
Sergeeva
O I
OI
Epstein
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*; D001682:Biological Availability; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*; D002319:Cardiovascular System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D012039:Regional Blood Flow / Q000187:drug effects; D012737:Sex Factors
C544065:AGTR1 protein, human; D000906:Antibodies; D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D044140:Receptor, Angiotensin, Type 1