[Comparisons of efficacy and safety of tolterodine and oxybutynin in children with idiopathic overactive bladder].
OBJECTIVE
To compare the efficacy and safety of tolterodine and oxybutynin in the treatment of idiopathic overactive bladder in children.


METHODS
A total of 204 children with idiopathic overactive bladder were randomly divided into three groups (n=68 each): placebo, tolterodine-treated and oxybutynin-treated. The efficacy and safety were evaluated two weeks after treatment.


RESULTS
The effective rate was 25% in the placebo group, 89% in the tolterodine-treated group, and 92% in the oxybutynin-treated group. The effective rate in the two treatment groups was significantly higher than that in the placebo group (P<0.05). There was a similar efficacy between the two treatment groups. The incidence of adverse events in the tolterodine-treated group (28%) was significantly lower than that in the oxybutnin-treated group (57%) (P<0.05).


CONCLUSIONS
Tolterodine has a similar efficacy to oxybutynin in the treatment of idiopathic overactive bladder in children, with better safety in pharmacotherapy.
Department of Urology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.
Yong-Ji
YJ
Deng
Geng
G
Ma
Yun-Fei
YF
Guo
Zheng
Z
Ge
Ru-Gang
RG
Lu
Li-Xia
LX
Wang
Hao-Bo
HB
Zhu
Chen-Jun
CJ
Chen
D000293:Adolescent; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003408:Cresols / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D010665:Phenylpropanolamine / Q000009:adverse effects / Q000627:therapeutic use*; D000068737:Tolterodine Tartrate; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
D001559:Benzhydryl Compounds; D003408:Cresols; D008333:Mandelic Acids; D018727:Muscarinic Antagonists; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate; C005419:oxybutynin