[Autoimmune reaction component in chronic pancreatitis: clinical and experimental study].
The study was undertaken to identify the relationship between inflammatory and autoimmune processes in chronic pancreatitis and to determine the prognostic significance of autoantibodies to antigens of acinar cells and hepatocytes, immunoglobulin G1-4.


METHODS
In 85 patients with CP (43 men, 42 women) were studied autoantibodies to antigens of acinar and liver cells, IgG1-4. Of these, 43 patients HP was characterized by complications (cysts, calcification, pseudotumoral form), 40 patients--HP without complications, 2 patients were diagnosed chronic autoimmune pancreatitis (CAP), confirmed histologically. 20 people-- the control group. Experimental studies on animals, reproduction of acute and chronic pancreatitis.


RESULTS
Maximize the level of autoantibodies--32.4 +/- 5.6 U / ml (control--10.5 +/- 2.5 U / ml) (p < or = 0.01), as well as IgG4--24 mg/ml in normal (0.8 +/- 0.08 mg/ml)--was recorded in patients with autoimmune pancreatitis. The average value of autoantibodies--in patients with CP complications: 24.2 +/- 3.8 U/ml (p < or = 0.01). The minimum value of autoantibodies--in patients with CP without complications: 18.6 +/- 2.6 U/ml (p < or = 0.05).


CONCLUSIONS
The course of autoimmune pancreatitis accompanied by an increase of autoantibodies to antigens of acinar and liver cells, as well as serum IgG1-4, especially IgG4, which reflects the intensity of the autoimmune responses in this disease. In addition, the exacerbation of chronic pancreatitis with complications is clearly defined autoimmune component of disease. Experimental studies with preimmunization of animals allogeneic tissues have convincingly demonstrated that the formation of antibodies is not only to the antigens, reflecting the specific characteristics of these tissues, but also to general cell structures of other tissues.
L V
LV
Vinokurova
I E
IE
Trubitsyna
N S
NS
Zhivaeva
A V
AV
Gubina
B Z
BZ
Chikunova
O V
OV
Kniazev
V E
VE
Sagynbaeva
D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D022781:Hepatocytes / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008297:Male; D046790:Pancreas, Exocrine / Q000276:immunology*; D050500:Pancreatitis, Chronic / Q000097:blood / Q000276:immunology*; D051381:Rats; D055545:gamma-Globins / Q000276:immunology
D001323:Autoantibodies; D015415:Biomarkers; D055545:gamma-Globins