A unique case of three autografts for acute myelogenous leukaemia with subsequent long term survival in second remission.
We report here a patient with acute mycloid leukaemia who relapsed 20 months after undergoing a double autograft procedure in first remission. He was reinduced and subsequently underwent a third autologous bone marrow transplantation in second remission using bone marrow harvested in second remission and a Busulphan and Cyclophosphamide conditioning regimen. Although the engraftment was very slow, he has remained in second remission for 34+ months. This case demonstrates that durable disease-free survival can be attained by a second preparative therapy, even in second remission, for patients relapsed after autologous bone marrow transplantation.
Departments of Haematology, University College Hospital, Gower Street, London.
S H
SH
Lim
A K
AK
McMillan
J
J
Gribben
M C
MC
Galvin
A H
AH
Goldstone