[Repetition of Helicobacter cinaedi infections during chemotherapy for malignant lymphoma].
A 70-year-old male, who had undergone resection of gastric malignant lymphoma in 1992, presented with cervical lymph node swelling in January 2008. Pathological examination of the lymph node biopsy demonstrated recurrence of malignant lymphoma, and he was treated with the R-CHOP regimen. Although he did not develop fever during the first through third course of R-CHOP, from the fourth course, he repeatedly demonstrated fever over 38°C for about one week after each course of chemotherapy, despite the absence of neutropenia. Helicobacter cinaedi infection was confirmed by blood culture each time. Although it is difficult to diagnose Helicobacter cinaedi infection by the standard culture method, increased numbers of recent reports especially in immunocompromised patients have emphasized the importance of diagnosing Helicobacter cinaedi infection.
Department of Internal Medicine, Kushiro Rosai Hospital, Japan.
Masayoshi
M
Ono
Shunsuke
S
Ohnishi
Reizo
R
Onishi
Shojiro
S
Takahashi
Yoshimitsu
Y
Kobayashi
Mio
M
Suzuki
Kimitoshi
K
Kubo
Masayoshi
M
Dazai
Junji
J
Yamamoto
Hisashi
H
Oda
Kenji
K
Tada
Tatsuro
T
Takahashi
Takuto
T
Miyagishima
D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002511:Cephalosporins / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D016998:Helicobacter / Q000302:isolation & purification; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local; D015242:Ofloxacin / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage; D000097586:Cefozopran
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D003520:Cyclophosphamide; D004317:Doxorubicin; D015242:Ofloxacin; D011239:Prednisolone; D014750:Vincristine; D000097586:Cefozopran