Short-Term Prognostic Index for Breast Cancer: NPI or Lpi.
Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi), using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic Index (NPI) for short-term breast cancer specific disease free survival. A total of 1818 operable breast cancer patients treated in the University Hospital of Leuven between 2000 and 2005 were included. The performance of the NPI and Lpi were compared on two levels: calibration and discrimination. The latter was evaluated using the concordance index (cindex), the number of patients in the extreme groups, and difference in event rates between these. The NPI had a significant higher cindex, but a significant lower percentage of patients in the extreme risk groups. After updating both indices, no significant differences between NPI and Lpi were noted.
Division SCD, Department of Electrical Engineering (ESAT), K.U.Leuven, Kasteelpark Arenberg 10/2446, 3000 Leuven, Belgium.
V
V
Van Belle
J
J
Decock
W
W
Hendrickx
O
O
Brouckaert
S
S
Pintens
P
P
Moerman
H
H
Wildiers
R
R
Paridaens
M R
MR
Christiaens
S
S
Van Huffel
P
P
Neven
Am J Clin Oncol. 2004 Jun;27(3):304-6
15170153
Cancer. 1989 Jan 1;63(1):181-7
2910416
Breast Cancer Res. 2004;6(6):R680-8
15535850
Surg Oncol Clin N Am. 2007 Jan;16(1):55-70
17336236
Int J Cancer. 2002 Jul 20;100(3):290-6
12115543
Lancet Oncol. 2007 Apr;8(4):331-48
17395107
J Clin Oncol. 2009 Mar 1;27(7):1062-8
19164210
Breast. 2004 Feb;13(1):23-7
14759712
Stat Med. 1984 Apr-Jun;3(2):143-52
6463451
Histopathology. 1991 Nov;19(5):403-10
1757079
Clin Cancer Res. 1999 Nov;5(11):3425-31
10589754
J Clin Oncol. 2009 Oct 20;27(30):e150-1; author reply e152
19720887
Cancer. 2005 May 15;103(10):2006-14
15812825
J Clin Oncol. 2005 Oct 20;23(30):7703-20
16157938
Breast Cancer Res Treat. 1992;22(3):207-19
1391987
Stat Med. 1999 Sep 15-30;18(17-18):2529-45
10474158
Eur J Surg Oncol. 2002 Aug;28(5):481-9
12217299
Eur J Cancer. 2001 Mar;37(5):591-6
11290434
Eur J Cancer. 2007 Jul;43(10):1548-55
17321736
Breast Cancer Res Treat. 2006 Jul;98(2):173-8
16538533
Radiother Oncol. 2004 Mar;70(3):225-30
15064006
J Clin Oncol. 2006 Jun 20;24(18):2910-6
16782931