Antibiotic Treatment of Dogs and Cats during Pregnancy.
The use of pharmacological agents in pregnant females poses a major clinical challenge due to the marked physiological changes that may modify the pharmacokinetics of drugs and to the potential effects on the fetus. The purpose of this paper is to review briefly our knowledge on the use of antibacterial drugs during pregnancy and to provide information for the judicious selection of an antimicrobial treatment for use in pregnant bitches and queens. The risk to the fetus is a result of the ability of a drug to reach the fetal circulation and to produce toxic effects. The placenta functions as a barrier that protects the fetus due to the presence of transporters and metabolising enzymes; however, during pregnancy, the presence and activity of both enzymes and transporters may change. Antimicrobial agents that have been shown to be safe for use during pregnancy include betalactams, macrolides, and lincosamides. Pharmacotherapy during pregnancy in all species may affect adversely the developing fetus; therefore, it should be avoided when possible.
Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Chorroarín 280, 1427 Buenos Aires, Argentina.
Marcela
M
Rebuelto
María Elena
ME
Loza
Antimicrob Agents Chemother. 2009 Apr;53(4):1624-7
19164141
Toxicol Lett. 2003 Apr 30;142(1-2):103-9
12765244
Placenta. 2005 Feb-Mar;26(2-3):218-25
15708123
J Pharm Sci. 2008 Sep;97(9):3483-93
18200507
Arch Dermatol. 1997 Jul;133(7):894-8
9236528
J Vet Pharmacol Ther. 2006 Aug;29(4):279-87
16846465
Theriogenology. 2008 Jun;69(9):1111-9
18407345
Vet Pathol. 1990 May;27(3):162-70
2353417
Adv Drug Deliv Rev. 1999 Jun 14;38(1):3-15
10837743
Eur J Obstet Gynecol Reprod Biol. 2003 Sep 22;110 Suppl 1:S50-4
12965090
Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):489-94
16023691
Ann Fr Anesth Reanim. 2010 Apr;29(4):e37-46
20347563
Placenta. 2008 Aug;29(8):743-7
18558430
J Vet Pharmacol Ther. 2000 Dec;23(6):359-63
11168913
Eur J Pharm Sci. 2010 Jan 31;39(1-3):76-81
19900541
J Antimicrob Chemother. 1999 May;43 Suppl B:91-100
10382881
Toxicol In Vitro. 2007 Oct;21(7):1332-40
17624715
Eur J Obstet Gynecol Reprod Biol. 2008 Jan;136(1):29-33
17350747
Eur J Obstet Gynecol Reprod Biol. 1998 Jan;76(1):21-7
9481541
Am J Med. 1989 Nov 30;87(5A):49S-51S
2589384
Am J Obstet Gynecol. 2008 Jan;198(1):126.e1-4
18166326
J Soc Gynecol Investig. 2004 Oct;11(7):438-48
15458740
Placenta. 2007 May-Jun;28(5-6):445-52
16904742
Best Pract Res Clin Obstet Gynaecol. 2001 Dec;15(6):819-26
11800526
Placenta. 2000 Mar-Apr;21(2-3):241-6
10736248
Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):381-7
15979662
Exp Mol Pathol. 2007 Dec;83(3):428-34
16824515
Placenta. 2007 Jan;28(1):39-46
16549198
J Toxicol Sci. 2002 Aug;27(3):219-28
12238145
Theriogenology. 2008 Jan 1;69(1):55-67
17976713
Br J Clin Pharmacol. 2008 Dec;66(6):866-74
19032729
Crit Rev Toxicol. 1998 Jan;28(1):35-72
9493761
J Toxicol Sci. 2010 Feb;35(1):97-100
20118629
Pharmacogenetics. 2001 Nov;11(8):727-33
11692082
Placenta. 1999 Sep;20(7):599-607
10452915
Cardiol Rev. 2004 Jul-Aug;12(4):201-21
15191632
J Am Acad Dermatol. 2001 Nov;45(5):S183-7
11606951
Crit Care Med. 2008 Aug;36(8):2433-40
18596628
Postgrad Med J. 1985 Nov;61(721):979-81
4070116
Infect Dis Obstet Gynecol. 2000;8(5-6):228-9
11220482
Adv Drug Deliv Rev. 1999 Jun 14;38(1):17-39
10837744
Biochem Pharmacol. 2008 Apr 15;75(8):1677-87
18342837
Placenta. 2007 Oct;28(10):1073-81
17524480
Ann Rech Vet. 1992;23(2):145-50
1610078
Drug Metab Pharmacokinet. 2009;24(2):167-74
19430173
Placenta. 2006 Aug;27(8):861-8
16313957
Fetal Diagn Ther. 2007;22(2):100-6
17135753
Eur J Obstet Gynecol Reprod Biol. 1995 Nov;63(1):81-90
8674572
Enferm Infecc Microbiol Clin. 2009 Nov;27(9):536-42
19850375
Best Pract Res Clin Obstet Gynaecol. 2001 Dec;15(6):971-86
11800536
Eur J Obstet Gynecol Reprod Biol. 2005 Sep 1;122(1):61-5
16154040
Theriogenology. 2008 Sep 15;70(5):746-57
18547636
Gend Med. 2006 Sep;3(3):169-82
17081950
J Vet Med A Physiol Pathol Clin Med. 2007 Oct;54(8):401-5
17877579
Reprod Toxicol. 2006 Oct;22(3):400-10
16563694
Antimicrob Agents Chemother. 1993 Jul;37(7):1510-7
8363384
Best Pract Res Clin Obstet Gynaecol. 2008 Oct;22(5):801-23
18760680
Res Vet Sci. 1990 Sep;49(2):190-3
2236915
Reprod Toxicol. 2001 Nov-Dec;15(6):619-29
11738515
Placenta. 2006 Nov-Dec;27(11-12):1096-102
16460798
Obstet Gynecol. 2005 Mar;105(3):473-9
15738010
Can Vet J. 2008 Nov;49(11):1141-2
19183741
J Am Vet Med Assoc. 2002 Dec 1;221(11):1568-71
12479325
Br J Pharmacol. 2007 May;151(2):163-74
17375082
Am Fam Physician. 2005 Mar 1;71(5):903-10
15768620
Toxicol Lett. 2008 Nov 10;182(1-3):50-6
18790027
Vet Clin North Am Small Anim Pract. 1986 May;16(3):525-38
3487156
Biochem Pharmacol. 2006 Aug 28;72(5):632-9
16828060
J Antimicrob Chemother. 1997 Dec;40 Suppl A:83-92
9484877
Antimicrob Agents Chemother. 1998 Jun;42(6):1336-9
9624471
Res Vet Sci. 2009 Jun;86(3):373-6
18995874
Antimicrob Agents Chemother. 1993 Jan;37(1):54-9
8431018
J Pharmacol Toxicol Methods. 2002 Nov-Dec;48(3):131-8
14986861
Anim Reprod Sci. 2002 Nov 15;74(1-2):87-99
12379378
Br J Pharmacol. 2009 Oct;158(3):665-78
19788499
Theriogenology. 2007 Sep 1;68(4):646-53
17602731
Am J Obstet Gynecol. 2010 Apr;202(4):383.e1-7
20350646
J Toxicol Sci. 2009;34 Suppl 2:SP267-71
19571479
Placenta. 2007 Apr;28 Suppl A:S125-8
17382383
Eur J Obstet Gynecol Reprod Biol. 2009 May;144 Suppl 1:S114-20
19297073
Mol Pharmacol. 2008 Jul;74(1):122-31
18381565
Am J Perinatol. 1998;15(9):523-5
9890248
Best Pract Res Clin Gastroenterol. 2007;21(5):849-77
17889812
Clin Microbiol Infect. 2008 Nov;14(11):989-94
19040470
Placenta. 2007 Aug-Sep;28(8-9):868-77
17482262
Gastroenterol Hepatol. 2010 Aug-Sep;33(7):517-29
20129703
Res Vet Sci. 2006 Dec;81(3):382-8
16697431
Antimicrob Agents Chemother. 1977 Apr;11(4):688-94
856021
Antimicrob Agents Chemother. 1992 Dec;36(12):2652-5
1482132
Am J Obstet Gynecol. 2008 Aug;199(2):169.e1-5
18674659
J Am Vet Med Assoc. 2003 Nov 15;223(10):1453-5, 1434
14627096
Indian J Pharm Sci. 2009 Jan;71(1):1-7
20177448
Placenta. 2006 Jun-Jul;27(6-7):602-9
16143395
Toxicol Appl Pharmacol. 1990 Sep 15;105(3):403-12
2237915