Direct determination of hydrogen cyanide in cigarette mainstream smoke by ion chromatography with pulsed amperometric detection.
The determination of hydrogen cyanide in cigarette mainstream smoke has been achieved by ion chromatography (IC) with pulsed amperometric detection (PAD). The proposed method of totally trapping whole cigarette mainstream smoke by Cambridge filters, which are treated with sodium hydroxide/ethanol solution, possesses the advantage of fast analysis time over the widespread used solution absorption method. The possible co-existing interferents are evaluated under the optimized detection conditions and excellent recoveries of cyanide are obtained. The cyanide content of absorption solution can be directly determined by the optimized IC-PAD method without any pretreatments. The linear range is 0.0147-2.45 μg/mL with R² value of 0.9997. The limit of the detection is 3 μg/L for a 25 μL injection loop. The overall relative standard deviation of the method is less than 5.20% and the recovery range from 94.3% to 101.0%. The results obtained from the developed method are in good agreement with that of continuous flow analyzer (CFA) method.
Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
Zi-Wei
ZW
Zhang
Ying-Bo
YB
Xu
Cheng-Hui
CH
Wang
Kai-Bo
KB
Chen
Hong-Wu
HW
Tong
Shao-Min
SM
Liu
D000838:Anions / Q000737:chemistry; D002852:Chromatography, Ion Exchange / Q000379:methods*; D055664:Electrochemical Techniques / Q000379:methods*; D006856:Hydrogen Cyanide / Q000032:analysis* / Q000737:chemistry; D016014:Linear Models; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014028:Tobacco Smoke Pollution / Q000032:analysis*
D000838:Anions; D014028:Tobacco Smoke Pollution; D006856:Hydrogen Cyanide