Prevalence and clinical characteristics of N-terminally truncated WT1 expression in acute myeloid leukemia.
Overexpression of the Wilms' tumor gene 1 (WT1) was observed in most leukemia cells. In addition to four major isoforms of WT1, an N-terminally truncated isoforms (sWT1) has been identified. We separately quantified the transcript levels of sWT1 and full-length WT1 (fWT1) in 237 patients with acute myeloid leukemia (AML). sWT1 expression was observed in 45 of 237 (19.0%) AML patients, particularly in acute promyelocytic leukemia (59.3%). Although sWT1 expression was not associated with other genetic mutations and prognosis, fWT1 expression level in sWT1-expressing AML was significantly higher than that in un-expressing AML. These results suggested the possible cooperation of sWT1 and fWT1 in the pathophysiology of AML, while further analysis is required.
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuichi
Y
Ishikawa
Hitoshi
H
Kiyoi
Tomoki
T
Naoe
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015973:Gene Expression Regulation, Leukemic; D005787:Gene Frequency; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D050505:Mutant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015995:Prevalence; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D025721:WT1 Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
D050505:Mutant Proteins; D020033:Protein Isoforms; D025721:WT1 Proteins