Aortic stenosis in a patient with Hurler's syndrome after bone marrow transplantation.
We describe a case of severe aortic stenosis in a 16-year-old male with Hurler's syndrome who had prior bone marrow transplantation. The excised aortic valve leaflets showed characteristic pathologic findings of Hurler's syndrome. This is the first case report of aortic valve replacement in a patient with Hurler's syndrome treated with bone marrow transplantation that demonstrates progression of the aortic valve disease despite treatment.
Department of Surgery, Division of Pediatric Cardiac Surgery, UCSF Benioff Children's Hospital, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Naruhito
N
Watanabe
Petros V
PV
Anagnostopoulos
Anthony
A
Azakie
D000293:Adolescent; D001021:Aortic Valve / Q000473:pathology; D001024:Aortic Valve Stenosis / Q000209:etiology* / Q000601:surgery; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006350:Heart Valve Prosthesis; D006801:Humans; D008059:Mucopolysaccharidosis I / Q000150:complications / Q000601:surgery