Moderate loading of the human osteoarthritic knee joint leads to lowering of intraarticular cartilage oligomeric matrix protein.
The non-pharmacological treatment of osteoarthritis (OA) includes exercise therapy; however, little is known about the specific effect of exercise on the joint per se. The purpose of the present study was to investigate the direct effects of a load-bearing exercise upon cartilage in a single, human osteoarthritic joint determined by biochemical markers of cartilage turnover and inflammation in the synovial fluid (SF), serum and urine. Eleven subjects with OA of the knee(s), but with no other joint- or inflammatory disorders, volunteered for the study and had samples of blood, urine and synovial fluid drawn both at baseline and following 30-min one-legged knee-extension exercise. Workload: 60% of 1 RM (Repetition Maximum). Determination of cartilage oligomeric matrix protein (COMP), aggrecan, C-terminal collagen II peptide (CTX-II) and interleukin (IL)-6 were performed in synovial fluid (SF), serum and urine. A significant decrease was found in SF concentration of COMP following exercise, whereas aggrecan, CTX-II and IL-6 remained unchanged. No differences in any of the tested markers were found in serum and urine between baseline and post-exercise. Thirty minutes of mechanical loading of a single knee joint in human subjects with knee OA resulted in a reduced COMP concentration in SF.
Institute of Sports Medicine, Department of Orthopaedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark. ida_caroe@dadlnet.dk
Ida C
IC
Helmark
Marie C H
MC
Petersen
Helle E
HE
Christensen
Michael
M
Kjaer
Henning
H
Langberg
D000328:Adult; D000368:Aged; D053674:Aggrecans / Q000378:metabolism; D064236:Cartilage Oligomeric Matrix Protein; D002358:Cartilage, Articular / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D007719:Knee Joint / Q000378:metabolism* / Q000503:physiopathology; D064235:Matrilin Proteins; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000378:metabolism* / Q000503:physiopathology; D013582:Synovial Fluid / Q000378:metabolism; D016474:Weight-Bearing / Q000502:physiology*
D053674:Aggrecans; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D015850:Interleukin-6; D064235:Matrilin Proteins; C577553:TSP5 protein, human
J Rheumatol. 2006 Nov;33(11):2271-9
17013996
Osteoarthritis Cartilage. 2005 Jan;13(1):34-8
15639635
Physiother Res Int. 1996;1(2):89-97
9238726
Arthritis Res Ther. 2007;9(1):R13
17284317
Mod Rheumatol. 2007;17(4):301-5
17694263
Br J Sports Med. 2000 Oct;34(5):326-31
11049140
Osteoarthritis Cartilage. 2000 May;8(3):222-9
10806050
JAMA. 1997 Jan 1;277(1):25-31
8980206
J Physiol. 2002 Aug 1;542(Pt 3):985-90
12154195
J Rheumatol. 1998 Dec;25(12):2432-9
9858441
Arthritis Rheum. 2008 Jun;58(6):1707-15
18512776
J Bone Joint Surg Am. 2000 Nov;82(11):1582-8
11097448
Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1272-8
12388119
Ann Rheum Dis. 2001 Jun;60(6):612-8
11350851
Osteoarthritis Cartilage. 1995 Mar;3(1):7-14
7719956
J Rheumatol. 1997 Feb;24(2):365-71
9034998
Scand J Rheumatol. 2007 Mar-Apr;36(2):136-9
17476620
Ann Rheum Dis. 1994 Jan;53(1):8-13
8311563
Osteoarthritis Cartilage. 2006 Jan;14(1):71-6
16188465
Arthritis Rheum. 1997 Apr;40(4):723-7
9125256
BMC Musculoskelet Disord. 2006 Dec 07;7:98
17156423
Osteoarthritis Cartilage. 2010 Jan;18(1):34-40
19679221
J Orthop Res. 2009 Nov;27(11):1408-13
19422040
Int Immunopharmacol. 2003 Dec;3(13-14):1901-8
14636839