Polymer/bacteria composite nanofiber non-wovens by electrospinning of living bacteria protected by hydrogel microparticles.
Physically crosslinked PVA-hydrogel microparticles are utilized for encapsulation of E. coli and M. luteus. The bacteria survive dry storage or treatment with bacteria-hostile organic solvents significantly better than unprotected bacteria as proven by culture-test experiments. The bacteria-protecting PVA microparticles are available for standard polymer-solution-processing techniques, as exemplarily shown by co-electrospinning of living bacteria encapsulated in dry PVA-hydrogel microparticles together with PVB-, PLLA-, and PCL-form organic solvents.
Philipps-Universität Marburg, Department of Chemistry and Scientific Center of Materials Science, Hans-Meerwein-Str., D-35032 Marburg, Germany.
Marco
M
Gensheimer
Astrid
A
Brandis-Heep
Seema
S
Agarwal
Rudolf K
RK
Thauer
Andreas
A
Greiner
D018914:Cells, Immobilized / Q000166:cytology / Q000187:drug effects; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000494:pharmacology*; D050296:Microbial Viability / Q000187:drug effects; D016982:Micrococcus luteus / Q000166:cytology / Q000187:drug effects*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011108:Polymers / Q000494:pharmacology*; D011142:Polyvinyl Alcohol / Q000494:pharmacology; D012997:Solvents
D011108:Polymers; D012997:Solvents; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011142:Polyvinyl Alcohol