Biomimetic approaches to control soluble concentration gradients in biomaterials.
Soluble concentration gradients play a critical role in controlling tissue formation during embryonic development. The importance of soluble signaling in biology has motivated engineers to design systems that allow precise and quantitative manipulation of gradient formation in vitro. Engineering techniques have increasingly moved to the third dimension in order to provide more physiologically relevant models to study the biological role of gradient formation and to guide strategies for controlling new tissue formation for therapeutic applications. This review provides an overview of efforts to design biomimetic strategies for soluble gradient formation, with a focus on microfluidic techniques and biomaterials approaches for moving gradient generation to the third dimension.
Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, Wisconsin 53705, USA.
Eric H
EH
Nguyen
Michael P
MP
Schwartz
William L
WL
Murphy
D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D032701:Biomimetics / Q000379:methods*; D016503:Drug Delivery Systems; D006801:Humans; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics / Q000379:methods; D015398:Signal Transduction
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