From Zn to Mn: the study of novel manganese-binding groups in the search for new drugs against tuberculosis.
In most eubacteria, apicomplexans, and most plants, including the causal agents for diseases such as malaria, leprosy, and tuberculosis, the methylerythritol phosphate pathway is the route for the biosynthesis of the C(5) precursors to the essential isoprenoid class of compounds. Owing to their absence in humans, the enzymes of the methylerythritol phosphate pathway have become attractive targets for drug discovery. This work investigates a new class of inhibitors against the second enzyme of the pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Inhibition of this enzyme may involve the chelation of a crucial active site Mn ion, and the metal-chelating moieties studied here have previously been shown to be successful in application to the zinc-dependent metalloproteinases. Quantum mechanics and docking calculations presented in this work suggest the transferability of these metal-chelating compounds to Mn-containing 1-deoxy-D-xylulose 5-phosphate reductoisomerase enzyme, as a promising starting point to the development of potent inhibitors.
Department of Chemistry & Biochemistry, University of California San Diego, La Jolla, CA 92093-0365, USA. swilliam@mccammon.ucsd.edu
Sarah L
SL
Williams
César Augusto F
CA
de Oliveira
H
H
Vazquez
J Andrew
JA
McCammon
D019747:Aldose-Ketose Isomerases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000995:Antitubercular Agents / Q000737:chemistry* / Q000627:therapeutic use; D001665:Binding Sites; D020134:Catalytic Domain; D002614:Chelating Agents / Q000737:chemistry; D003198:Computer Simulation; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D008345:Manganese / Q000737:chemistry*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010088:Oxidoreductases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011789:Quantum Theory; D014376:Tuberculosis / Q000188:drug therapy*; D015032:Zinc / Q000737:chemistry*
D000995:Antitubercular Agents; D002614:Chelating Agents; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; D008345:Manganese; D010088:Oxidoreductases; C114231:1-deoxy-D-xylulose 5-phosphate reductoisomerase; D019747:Aldose-Ketose Isomerases; D015032:Zinc
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