Neonatal meningitis according to the microbiological diagnosis: a decade of experience in a tertiary center.
The aim of this study was to evaluate the incidence of and mortality due to meningitis and compare data according to microbiological diagnosis. This was a ten-year retrospective study conducted at a neonatal intensive care unit (NICU). Newborns with meningitis confirmed by positive CSF culture were included; those with congenital infection or malformations that made lumbar puncture impossible were excluded. The variables investigated were birth weight, gestational and postnatal age, procedures, hematological and CSF parameters, and complications. Parametric and non-parametric tests were used (statistical value p<0.05). The incidence of meningitis was 0.6% and mortality was 27%. Of the 22 cases, 59% involved Gram-negative bacteria; 36% Gram-positive and 5% fungi. The groups did not differ in relation to birth weight, gestational and postnatal age, procedures or hematological and CSF parameters. Sepsis, convulsions and deaths were frequent in both groups, without statistical difference. Gram-negative cases showed abscesses and higher frequency of ventriculitis and hydrocephaly. Meningitis was infrequent, but presented high mortality and frequent complications.
Department of Pediatrics, Hospital das Clínicas, Botucatu Medical School, UNESP, SP, Brazil. mbentlin@fmb.unesp.br
Maria Regina
MR
Bentlin
Gabriel Luís
GL
Ferreira
Ligia Maria Suppo de Souza
LM
Rugolo
Geraldo Henrique Soares
GH
Silva
Alessandro Lia
AL
Mondelli
Antonio
A
Rugolo Júnior
D001938:Brazil / Q000453:epidemiology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology* / Q000401:mortality; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D016920:Meningitis, Bacterial / Q000382:microbiology* / Q000401:mortality; D012189:Retrospective Studies