Role of the rostral ventrolateral medulla (RVLM) in the patterning of vestibular system influences on sympathetic nervous system outflow to the upper and lower body.
Research on animal models as well as human subjects has demonstrated that the vestibular system contributes to regulating the distribution of blood in the body through effects on the sympathetic nervous system. Elimination of vestibular inputs results in increased blood flow to the hindlimbs during vestibular stimulation, because it attenuates the increase in vascular resistance that ordinarily occurs in the lower body during head-up tilts. Additionally, the changes in vascular resistance produced by vestibular stimulation differ between body regions. Electrical stimulation of vestibular afferents produces an inhibition of most hindlimb vasoconstrictor fibers and a decrease in hindlimb vascular resistance, but an initial excitation of most upper body vasoconstrictor fibers accompanied by an increase in upper body vascular resistance. The present study tested the hypothesis that neurons in the principal vasomotor region of the brainstem, the rostral ventrolateral medulla (RVLM), whose projections extended past the T10 segment, to spinal levels containing sympathetic preganglionic neurons regulating lower body blood flow, respond differently to electrical stimulation of the vestibular nerve than RVLM neurons whose axons terminate rostral to T10. Contrary to our hypothesis, the majority of RVLM neurons were excited by vestibular stimulation, despite their level of projection in the spinal cord. These findings indicate that the RVLM is not solely responsible for establishing the patterning of vestibular-sympathetic responses. This patterning apparently requires the integration by spinal circuitry of labyrinthine signals transmitted from the brainstem, likely from regions in addition to the RVLM.
Department of Otolaryngology, University of Pittsburgh, Eye and Ear Institute, Pittsburgh, PA 15213, USA.
Yoichiro
Y
Sugiyama
Takeshi
T
Suzuki
Bill J
BJ
Yates
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D017776:Autonomic Pathways / Q000502:physiology*; D001703:Biophysics; D001931:Brain Mapping; D002415:Cats; D016009:Chi-Square Distribution; D003655:Decerebrate State; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*; D014725:Vestibular Nerve / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000502:physiology*
J Appl Physiol (1985). 1999 May;86(5):1552-60
10233117
Acta Physiol Scand. 2003 Mar;177(3):313-9
12609001
J Physiol. 2005 Apr 1;564(Pt 1):321-7
15705649
Brain Res. 1998 Mar 9;786(1-2):153-64
9554992
J Neurophysiol. 1994 Jun;71(6):2087-92
7931504
Trends Neurosci. 1992 Dec;15(12):475-81
1282743
Am J Physiol. 1984 Nov;247(5 Pt 2):R761-7
6093601
Brain Res. 1986 Jul 9;377(2):279-85
3730863
Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R118-25
10896872
J Auton Nerv Syst. 1987 Jul;20(1):73-86
2443549
Prog Brain Res. 1989;81:233-42
2694221
J Auton Nerv Syst. 1986 Feb;15(2):131-40
3958433
Brain Res. 2003 Jun 27;976(2):185-93
12763252
Neurosci Lett. 1990 Mar 2;110(1-2):91-6
1970144
Clin Exp Hypertens. 1981;3(3):379-91
6265165
J Auton Nerv Syst. 1990 Jul;30 Suppl:S185-90
2212486
J Chem Neuroanat. 2009 Nov;38(3):222-30
19665549
Prog Neurobiol. 1994 Feb;42(2):197-227
8008825
Can J Physiol Pharmacol. 1987 Aug;65(8):1572-9
3319108
J Auton Nerv Syst. 1992 Jan;37(1):1-10
1593089
Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R681-8
18199586
Prog Brain Res. 2006;152:27-37
16198691
Brain Res. 1991 Jun 28;552(2):265-72
1913189
J Appl Physiol (1985). 1989 Jun;66(6):2778-81
2745341
J Chem Neuroanat. 2009 Nov;38(3):231-9
19524034
Neurosci Lett. 1990 Mar 26;111(1-2):139-43
2336179
Brain Res. 2004 Jan 16;996(1):126-37
14670639
J Chem Neuroanat. 2009 Nov;38(3):209-21
19549567
J Auton Nerv Syst. 1985 Nov;14(3):239-54
4067185
J Physiol. 1976 Jun;258(2):337-55
957160
J Comp Neurol. 2004 Apr 12;471(4):462-81
15022264
Brain Res. 1993 Jul 9;616(1-2):251-62
7689411
Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R109-17
10896871
Am J Physiol. 1998 Sep;275(3):R824-35
9728081
Clin Exp Pharmacol Physiol. 2002 Jan-Feb;29(1-2):98-102
11906466
Brain Res. 1993 Dec 3;629(2):209-17
8111625
J Neurophysiol. 2001 Apr;85(4):1697-708
11287492
Brain Res. 1994 Jan 21;634(2):227-34
8131072
J Auton Nerv Syst. 1986 Oct;17(2):151-64
3782723
Brain Res Brain Res Rev. 1992 Jan-Apr;17(1):51-9
1638275
J Physiol. 1994 Nov 15;481 ( Pt 1):233-41
7853246
Clin Exp Hypertens A. 1984;6(1-2):221-41
6365368
Brain Res Brain Res Rev. 1998 Nov;28(1-2):73-82
9795146
J Appl Physiol (1985). 2009 Jan;106(1):138-52
18974365
J Physiol. 2002 Jan 1;538(Pt 1):303-8
11773337
Am J Physiol. 1995 Jun;268(6 Pt 2):R1381-5
7611512
Brain Res. 1995 Aug 21;689(2):197-206
7583323
Brain Res. 1988 Jul 5;455(1):187-91
3416186
Am J Physiol. 1996 Oct;271(4 Pt 2):R1070-7
8898002
J Physiol. 2006 Sep 1;575(Pt 2):671-84
16809368
J Physiol. 1989 Jan;408:571-86
2778740
Auton Neurosci. 2010 Apr 19;154(1-2):89-93
19939746
J Neurophysiol. 1985 Jun;53(6):1551-66
2989448
Clin Exp Hypertens. 1997 Jul-Aug;19(5-6):607-18
9247742
Neuroscience. 1986 May;18(1):51-9
2874523
J Auton Nerv Syst. 1983 Feb;7(2):119-39
6875185
J Comp Neurol. 1992 Dec 22;326(4):527-48
1336502
Brain Res. 2004 Apr 9;1004(1-2):1-7
15033414
J Cardiovasc Pharmacol. 2001 Oct;38 Suppl 1:S7-11
11811364
J Physiol. 1988 Jan;395:41-56
2900889
Am J Physiol. 1985 Apr;248(4 Pt 2):H547-67
3985177
Neurosci Lett. 1981 Jun 12;24(1):25-8
7266936
Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1532-41
17158263
Brain Res. 1982 Oct 14;249(2):223-35
6128058
J Hypertens. 2002 Sep;20(9):1675-88
12195099
J Neurophysiol. 1975 Nov;38(6):1421-35
1221080
J Neurophysiol. 1968 Mar;31(2):176-85
5687381
J Auton Nerv Syst. 1992 May 1;38(2):117-37
1377728
Mol Cell Endocrinol. 2009 Apr 29;302(2):167-75
19027823
J Vestib Res. 1998 Jan-Feb;8(1):17-25
9416585
Am J Physiol Regul Integr Comp Physiol. 2009 Dec;297(6):R1777-84
19793952