Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer.
BACKGROUND
Concurrent inhibition of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) is an active and well tolerated regimen in recurrent head and neck cancer (HNC). In the current phase 1 trial, the authors sought to determine the maximum tolerated dose (MTD) and efficacy of concurrent erlotinib and celecoxib as a radiosensitizing regimen.


METHODS
Fourteen patients with previously irradiated HNC with no distant metastases who required reirradiation were eligible. Treatment consisted of daily erlotinib 150 mg and twice daily celecoxib (escalated from 200 mg to 600 mg using a 3 + 3 design with an expanded cohort at the MTD) starting on Day 1 and was continued during radiation. Daily radiation was started on Day 15, and maintenance erlotinib was recommended.


RESULTS
The recommended phase 2 dose of celecoxib was 400 mg. Three dose-limiting toxicities included late in-field orocutaneous fistula (Dose Level 2), osteonecrosis (Dose Level 3), and trismus (Dose Level 3). Acute grade ≥ 3 toxicities were uncommon and included mucositis (21%) and dermatitis (14%). At a median follow-up of 11 months, the 1-year locoregional control, progression-free survival, and overall survival rates were 60%, 37%, and 55%, respectively.


CONCLUSIONS
Concurrent erlotinib, celecoxib, and reirradiation was a feasible and clinically active regimen in a population of patients with recurrent HNC who had a poor prognosis.
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York, USA. johnnykaomd@gmail.com
Johnny
J
Kao
Eric M
EM
Genden
Chien-Ting
CT
Chen
Michael
M
Rivera
Charles C L
CC
Tong
Kryztof
K
Misiukiewicz
Vishal
V
Gupta
Vivek
V
Gurudutt
Marita
M
Teng
Stuart H
SH
Packer
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D000069347:Erlotinib Hydrochloride; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D011720:Pyrazoles / Q000008:administration & dosage*; D011799:Quinazolines / Q000008:administration & dosage*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D019233:Retreatment; D013449:Sulfonamides / Q000008:administration & dosage*
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D011799:Quinazolines; D011838:Radiation-Sensitizing Agents; D013449:Sulfonamides; D000069347:Erlotinib Hydrochloride; D066246:ErbB Receptors; D000068579:Celecoxib