Hyrtioseragamines A and B, new alkaloids from the sponge Hyrtios species.
Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Yohei
Y
Takahashi
Yoshiro
Y
Iinuma
Takaaki
T
Kubota
Masashi
M
Tsuda
Mitsuhiro
M
Sekiguchi
Yuzuru
Y
Mikami
Jane
J
Fromont
Jun'ichi
J
Kobayashi
D000470:Alkaloids / Q000737:chemistry; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003455:Cryptococcus neoformans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008386:Marine Biology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011719:Pyrazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000470:Alkaloids; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D005663:Furans; D011719:Pyrazines; C556698:hyrtioseragamine A; C556699:hyrtioseragamine B