Glycans in melanoma screening. Part 2. Towards the understanding of integrin N-glycosylation in melanoma.
Although melanoma is one of the most studied malignancies, it still remains challenging for biomedicine. Since aberrant glycosylation has been considered as an important hallmark of cancer for many years, melanoma glycomic studies give a chance of better understanding the biology of the disease. The multistage nature of melanoma development, which is accompanied by changes in the expression of adhesion receptors from the integrin family, provides a chance for searching for neoglycoforms of proteins that can be considered as future sensitive melanoma biomarkers. The β1,6-branching, sialylation and fucosylation seem to be important modifications of integrin N-glycans in the case of malignant melanoma progression.
Department of Glycoconjugate Biochemistry, Institute of Zoology, Jagiellonian University, ul. Ingardena 6, 30-060 Krakow, Poland. p.link-lenczowski@uj.edu.pl
Paweł
P
Link-Lenczowski
Anna
A
Lityńska
D018450:Disease Progression; D055088:Early Detection of Cancer; D006031:Glycosylation; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000378:metabolism*; D008545:Melanoma / Q000737:chemistry / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
D016023:Integrins; D011134:Polysaccharides