Karyopherins in nuclear transport of homeodomain proteins during development.
Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking. The accurate nucleocytoplasmic distribution of these proteins is essential for their functions. We summarize information on (a) the roles of karyopherins for import and export of homeoproteins, (b) the regulation of their nuclear transport during development, and (c) the corresponding complexity of homeoprotein nucleocytoplasmic transport signals. This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import.
Xiamen University School of Life Sciences, Xiamen, Fujian 361005, China.
Wenduo
W
Ye
Wenbo
W
Lin
Alan M
AM
Tartakoff
Tao
T
Tao
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D048788:Growth and Development / Q000502:physiology; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D028884:Karyopherins / Q000502:physiology*; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019913:Nuclear Localization Signals / Q000502:physiology; D010766:Phosphorylation; D054730:Protein Interaction Domains and Motifs; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology
D018398:Homeodomain Proteins; D028884:Karyopherins; D019913:Nuclear Localization Signals
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