[Neuromediator systems in some brain regions of rats subjected to morphine intoxication].
The content of neuromediators and its metabolites in the cortex of cerebral hemispheres, in thalamus and brain stem was studied under chronic morphine intoxication (7-21 days). The morphine intake during 7-14 days was accompanied by changes of catecholamine system functioning, which was the most pronounced in the thalamus and the brain stem. These changes included increased secretion of dophamine and noradrenaline, their decrease in the brain tissue, and the increased content of their metabolites. The changes of serotonin and GABA content were less pronounced and included a decrease of serotonin level and the increase of the GABA content in different periods of narcotization.
S V
SV
Lelevich
A A
AA
Novokshonov
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000009:adverse effects* / Q000494:pharmacology; D009294:Narcotics / Q000009:adverse effects* / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009293:Opioid-Related Disorders / Q000401:mortality*; D051381:Rats
D002395:Catecholamines; D009294:Narcotics; D018377:Neurotransmitter Agents; D009020:Morphine