Sorafenib-induced interstitial pneumonitis in a patient with hepatocellular carcinoma: a case report.
Sorafenib is an oral multikinase inhibitor that has shown a survival benefit in patients with advanced hepatocellular carcinoma, and is considered to be generally safe. We treated a patient with interstitial lung disease that was associated with sorafenib therapy for the treatment of advanced hepatocellular carcinoma. A 74-year-old man with hepatitis-C-virus-related hepatocellular carcinoma was treated with sorafenib. After 8 days of sorafenib administration, he received radiation therapy for an intrahepatic tumor located in segment eight. On the 24th day of sorafenib treatment, the patient developed acute interstitial pneumonitis that rapidly improved after the discontinuation of sorafenib and treatment with high-dose steroids. This case alerts physicians to the possibility of sorafenib-induced interstitial lung disease.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Hyung-Joon
HJ
Myung
Sook-Hyang
SH
Jeong
Jin-Wook
JW
Kim
Hee-Sup
HS
Kim
Je-Hyuck
JH
Jang
Ho Il
HI
Yoon
Jae-Sung
JS
Kim
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