Acoustic radiation contrast in MR images for breast cancer diagnostics--initial phantom study.
Acoustic radiation contrast in magnetic resonance images is an approach to visualize the changes in ultrasonic loss and viscoelastic changes of the sample with the resolution of a magnetic resonance imaging (MRI) system. By irradiating ultrasound (US) into a tissue-mimicking sample, a displacement along the US beam path caused by the acoustic radiation force is obtained. This displacement varies with the US intensity, the duration of irradiation, the US attenuation and the viscoelastic properties of the sample. US pulses of 2.5 MHz with a duration of 20 ms and an intensity of <17 W/cm(2) are used. An MRI sequence was programmed to produce images in which the magnitude of the displacement is visualized by gray value changes. In addition, a finite element simulation of the measurements was performed to demonstrate the feasibility of the method. Through examination of the measurements and the simulations, information about viscoelastic changes was achieved. In this work, measurements on different breast phantoms are presented.
Helmholtz-Institut für Strahlen- und Kernphysik, University of Bonn, Bonn, Germany. marcus.radicke@gmx.de
M
M
Radicke
J
J
Mende
A-L
AL
Kofahl
J
J
Wild
D
D
Ulucay
B
B
Habenstein
M
M
Deimling
P
P
Trautner
B
B
Weber
K
K
Maier
D000162:Acoustics; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004548:Elasticity; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D019047:Phantoms, Imaging; D014463:Ultrasonography; D014783:Viscosity