Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production.
Experiments on outbred mice showed that acetylcholine chloride in a dose of 20 mg/kg 6 h after subcutaneous injection significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×10(9) E. coli bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.
Saratov Military Institute of Biological and Chemical Safety, Russia. pz@renet.com.ru
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Zabrodskii
D000109:Acetylcholine / Q000627:therapeutic use*; D000818:Animals; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli; D005260:Female; D053583:Interleukin-1beta; D015850:Interleukin-6; D008297:Male; D051379:Mice; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha
D016207:Cytokines; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D000109:Acetylcholine