Tandem reaction of propargylic alcohol, sulfonamide, and N-iodosuccinimide: synthesis of N-(2-iodoinden-1-yl)arenesulfonamide.
An efficient and straightforward strategy for the synthesis of N-(2-haloinden-1-yl)arenesulfonamides from propargylic alcohols and sulfonamides is described. Allenesulfonamide is postulated to be the key intermediate for this tandem transformation.
Department of Chemistry, Zhejiang University, Hangzhou, P R China.
Yuanxun
Y
Zhu
Guangwei
G
Yin
Deng
D
Hong
Ping
P
Lu
Yanguang
Y
Wang
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D006847:Hydrocarbons, Iodinated; D007192:Indenes; C557935:N-(2-iodoinden-1-yl)arenesulfonamide; D020005:Propanols; D013388:Succinimides; D013449:Sulfonamides; C008155:N-iodosuccinimide; C028255:propargyl alcohol