[The effect of volatile antioxidants of plant origin on leukemogenesis in mice].
The effect of savory essential oil added with drinking water (150 ng/ml) or with feed (2.5 microg/g) on the lifetime of AKR mice and the parameters of oxidative stress in animal blood were investigated. It was found for the first time that long-term administration of an essential oil in low doses increased the average lifetime of mice by 20-35% and was accompanied by a decrease in the hemolysis level and the content of lipid peroxidation products in erythrocytes of mice, as well as alteration in the structural state of their membranes and stabilization of polyunsaturated fatty acids level in mice liver cells.
E B
EB
Burlakova
V N
VN
Erokhin
T A
TA
Misharina
L D
LD
Fatkullina
A V
AV
Krementsova
V A
VA
Semenov
M B
MB
Terenina
A K
AK
Vorob'eva
A N
AN
Goloshchapov
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007938:Leukemia / Q000097:blood / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008136:Longevity / Q000187:drug effects*; D051379:Mice; D008806:Mice, Inbred AKR; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D031362:Satureja / Q000737:chemistry*
D009822:Oils, Volatile