[Lipid peroxidation, activity of Na+,k(+) -ATPase and exzymes of antioxidant defence in rats with nephropathy induced by cobalt chloride].
Chronic parenteral administration of cobalt chloride (6 mg/kg) to male rats for 2 weeks or 1 month was accompanied by activation of lipid peroxidation (LPO), a decrease of superoxide dismutase activity and an increase of catalase activity. The membrane toxic action also resulted in a decrease of cortical and medullar Na+,K(+)-ATPase activity of kidneys, and the decrease in renal functions (glomerular filtration, renal water reabsorption, spontaneous diuresis, electrolyte excretion).
A I
AI
Tedtoeva
F S
FS
Dzugkoeva
I V
IV
Mozhaeva
S G
SG
Dzugkoev
D000818:Animals; D016587:Antimutagenic Agents / Q000009:adverse effects* / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D003035:Cobalt / Q000009:adverse effects* / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000201:enzymology; D007674:Kidney Diseases / Q000139:chemically induced / Q000201:enzymology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D016587:Antimutagenic Agents; D000975:Antioxidants; D003035:Cobalt; D002374:Catalase; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase; C018021:cobaltous chloride