Effects of lipoic acid on proliferation and apoptosis of liver cells in rats with metabolic stress.
Lipoic acid stimulated expression of heat shock proteins 25, 70, and 90 in liver cells of Wistar rats with metabolic stress (5 days of food deprivation followed by complete resumption of nutrition). Lipoic acid in a dose of 25 mg/kg reduced proliferation of hepatic lymphocytes during fasting, while after resumption of feeding it stimulated hepatocyte proliferation due to differentiated regulation of the expression of cyclin D1 and Rb protein in these cell populations.
Institute of Nutrition, the Russian Academy of Medical Sciences, Moscow, Russia. e.a.martinova@gmail.coma
E A
EA
Martinova
A V
AV
Vasiliev
N E
NE
Sharanova
M M
MM
Gapparov
D000704:Analysis of Variance; D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects*; D019938:Cyclin D1 / Q000378:metabolism; D005215:Fasting / Q000502:physiology; D005260:Female; D008099:Liver / Q000166:cytology / Q000502:physiology*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D016160:Retinoblastoma Protein / Q000378:metabolism; D013312:Stress, Physiological / Q000502:physiology*; D008063:Thioctic Acid / Q000494:pharmacology*
D016160:Retinoblastoma Protein; D019938:Cyclin D1; D008063:Thioctic Acid