Disappearance of angina pectoris by lipid-lowering in type III hyperlipoproteinemia.
Type III hyperlipoproteinemia is a rare familial disease characterized by marked elevations of serum cholesterol and triglyceride levels caused by an accumulation of remnant lipoproteins in apolipoprotein E2/E2 homozygotes. It is associated with an increased risk for premature atherosclerotic vascular disease. A 55-year-old woman was diagnosed as having type III hyperlipoproteinemia on the basis of skin lesions, serum lipid levels, lipid electrophoresis, and apolipoprotein E genotyping and stable angina pectoris on the basis of typical symptoms and treadmill exercise electrocardiographic results. After 1 year of combination therapy with atorvastatin and fenofibrate, skin xanthomata disappeared, leaving minimal remnants. In addition, there was no exertional chest pain, and treadmill exercise electrocardiographic results were negative. This finding was confirmed by coronary computed tomographic angiography. This case suggests that proper medical therapy can induce the regression of uncomplicated coronary lesions in type III hyperlipoproteinemia.
Department of Internal Medicine, College ofMedicine, Chung-Ang University, Seoul, Korea.
Eun Jeung
EJ
Cho
Yun Joo
YJ
Min
Min Seok
MS
Oh
Jee Eun
JE
Kwon
Jeung Eun
JE
Kim
Chee Jeong
CJ
Kim
D000787:Angina Pectoris / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000069059:Atorvastatin; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D011345:Fenofibrate / Q000627:therapeutic use; D005500:Follow-Up Studies; D006538:Heptanoic Acids / Q000627:therapeutic use; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008875:Middle Aged; D011758:Pyrroles / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D011758:Pyrroles; D000069059:Atorvastatin; D011345:Fenofibrate