Mathematical modeling of energy metabolism and hemodynamics of WHO grade II gliomas using in vivo MR data.
Therapeutic management of low-grade gliomas (LGG) is a challenge because they have undergone anaplastic transformation with variable delay. Today, only progressive volume growth on successive MRI allows an in vivo monitoring of this evolution. On the other hand, multinuclear spectroscopy and perfusion available during MRI may also provide assessment of metabolic changes underlying morphological modifications. To overcome this drawback, we developed a mathematical model of the metabolism and the hemodynamic of gliomas, based on a physiological model previously published, and including the MR parameters. This allows us to suggest that some specific profiles of metabolic and hemodynamic changes would be good indicators of potential anaplastic transformation.
Inserm U678, Functional Imaging Laboratory, Department of Neuroradiology, Pitié-Salpêtrière Hospital, UPMC Univ Paris 06, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. remy.guillevin@psl.aphp.fr
Rémy
R
Guillevin
Carole
C
Menuel
Jean-Noël
JN
Vallée
Jean-Pierre
JP
Françoise
Laurent
L
Capelle
Christophe
C
Habas
Giovanni
G
De Marco
Jacques
J
Chiras
Robert
R
Costalat
D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001932:Brain Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D002794:Choline / Q000378:metabolism; D005260:Female; D005910:Glioma / Q000098:blood supply* / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007091:Image Processing, Computer-Assisted; D019344:Lactic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology; D055815:Young Adult
D019344:Lactic Acid; D002794:Choline