Serum C-reactive protein level and prediabetes in two Asian populations.
OBJECTIVE
Prediabetes, an early stage in the hyperglycaemic continuum, increases the future risk of developing diabetes and cardiovascular disease (CVD). C-reactive protein (CRP), a marker of inflammation, is associated with diabetes and CVD. However, studies examining the association between CRP and prediabetes among participants without diabetes are limited.


METHODS
We analysed data from two large population-based studies in Singapore: the Singapore Prospective Study Programme (SP2, n = 4,252 Chinese, Malay and Indians aged ≥ 24 years) and the Singapore Malay Eye Study (SiMES, n = 2,337 Malays aged 40-80 years), participants of which were free of diabetes mellitus. Prediabetes was defined as glycated haemoglobin of 5.7-6.4% in SiMES (n = 1,231); fasting plasma glucose of 5.6-6.9 mmol/l in SP2 (n = 386).


RESULTS
Elevated high sensitivity CRP (hsCRP) levels were found to be associated with prediabetes after adjusting for age, sex, race-ethnicity, education, smoking, alcohol consumption, hypertension, BMI and total cholesterol. Comparing those with hsCRP <1 mg/l (referent), the OR (95% confidence interval) of prediabetes in persons with hsCRP 1-3 mg/l and >3 mg/l was 1.31 (0.99-1.74) and 2.17 (1.61-2.92), p (trend) < 0.0001 in SP2; 1.23 (1.00-1.52) and 1.31 (1.06-1.64), p (trend) = 0.02 in SiMES. In subgroup analysis, the association was stronger in women, Chinese and Malays, and participants with BMI < 25 kg/m(2).


CONCLUSIONS
Data from two population-based Asian cohorts suggest that elevated serum hsCRP levels are associated with prediabetes.
Department of Community Medicine, West Virginia University School of Medicine, PO Box 9190, Morgantown, WV 26506-9190, USA. csabanayagam@hsc.wvu.edu
C
C
Sabanayagam
A
A
Shankar
S C
SC
Lim
J
J
Lee
E S
ES
Tai
T Y
TY
Wong
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood*; D055815:Young Adult
D001786:Blood Glucose; D002097:C-Reactive Protein
Diabetes Care. 2007 Apr;30(4):854-60
17392546
Dis Markers. 2009;26(4):163-70
19729797
Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):650-5
12692007
J Clin Endocrinol Metab. 2009 Jun;94(6):2099-105
19318443
Diabetes Care. 2009 Feb;32(2):287-94
19017771
J Am Coll Cardiol. 2010 Mar 30;55(13):1310-7
20338491
Am J Epidemiol. 1996 Feb 1;143(3):228-39
8561156
Circ Cardiovasc Qual Outcomes. 2008 Nov;1(2):92-7
20031795
J Hypertens. 2009 Nov;27(11):2209-17
19620884
Diabetes Res Clin Pract. 2003 Jul;61 Suppl 1:S9-S18
12880690
Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):972-8
10195925
Ophthalmic Epidemiol. 2007 Jan-Feb;14(1):25-35
17365815
Diabetes Care. 2008 Feb;31 Suppl 2:S155-60
18227478
Ann Intern Med. 2009 Oct 6;151(7):483-95
19805771
J Clin Endocrinol Metab. 2009 Jun;94(6):2123-7
19336513
BMC Med Res Methodol. 2003 Oct 20;3:21
14567763
Diabetes. 2001 Oct;50(10):2384-9
11574423
Circulation. 2001 Jul 10;104(2):145-50
11447077
J Clin Endocrinol Metab. 1999 Jan;84(1):137-44
9920074
J Clin Endocrinol Metab. 2009 Sep;94(9):3171-82
19509100
Circulation. 2004 Jun 1;109(21 Suppl 1):II2-10
15173056
Diabetes Res Clin Pract. 2004 May;64(2):99-106
15063602
Diabetes Metab Res Rev. 2009 Mar;25(3):219-23
19116941
Diabet Med. 2002 Nov;19(11):939-43
12421431
Diabetes Care. 2006 Aug;29(8):1902-8
16873800
Diabetes. 2004 Oct;53(10):2569-73
15448085
Am J Epidemiol. 2002 Jan 1;155(1):65-71
11772786
N Engl J Med. 1999 Jan 14;340(2):115-26
9887164
J Clin Invest. 1995 May;95(5):2409-15
7738205
Circulation. 2007 Mar 27;115(12):1544-50
17353438
Diabet Med. 2004 Jan;21(1):39-44
14706052
Circulation. 2003 Oct 14;108(15):1822-30
14517163
Diabetes Care. 2005 May;28(5):1211-3
15855593
Obes Rev. 2002 Aug;3(3):209-15
12164474
Am J Epidemiol. 2001 Jun 15;153(12):1183-90
11415953
Diabetes Care. 2005 Oct;28(10):2497-500
16186286
Int J Obes. 1988;12(2):157-62
3384560
Diabet Med. 2005 Jul;22(7):863-70
15975100
J Clin Endocrinol Metab. 2009 Dec;94(12):4696-702
19820012
Diabetes Care. 2010 Jan;33 Suppl 1:S11-61
20042772
Diabetes Res Clin Pract. 2005 Jul;69(1):88-98
15955391
Ann Clin Lab Sci. 2006 Spring;36(2):163-9
16682512
N Engl J Med. 2000 Mar 23;342(12):836-43
10733371
Diabetes Res Clin Pract. 2004 Jan;63(1):19-26
14693409
Diabetes Care. 1998 Sep;21(9):1414-31
9727886
Curr Diab Rep. 2004 Aug;4(4):237-46
15265464