Glycaemic rises after waking up in response to an alarm clock in type 1-diabetic patients analysed with continuous glucose monitoring (GlucoDay® S).
OBJECTIVE
Waking up in response to an alarm-clock may evoke a stress reaction that leads to rising glucose concentrations.


METHODS
30 type 1-diabetic patients participated in 3 overnight conditions: (a) with an alarm-clock set at 2 h intervals for glucose self monitoring, (b) with a nurse performing blood glucose determinations, and (c) with the patients left undisturbed. Continuous glucose monitoring (CGM) was performed with a GlucoDay® S device.


RESULTS
After waking up in response to an alarm-clock, CGM-determined glucose concentrations rose by 18±6 mg/dl at 4 a.m. (p=0.0003), whereas negligible increments were seen with nurse assistance (e. g., 0±4 mg/dl at 4 a.m.).


CONCLUSIONS
Waking up in response to an alarm-clock leads to an arousal reaction that causes significant elevations in glucose concentrations. Continuous glucose monitoring is a suitable method to detect such short-lived increments in glucose concentrations. But at the moment the CGMS is not able to substitute for inpatient glucose profiles.
Diabeteszentrum Bad Lauterberg im Harz, Germany.
C
C
Berndt-Zipfel
L
L
Köthe
B
B
Nawrodt
B
B
Mraz
A
A
Patzelt-Bath
M A
MA
Nauck
D000328:Adult; D001143:Arousal; D001786:Blood Glucose; D015190:Blood Glucose Self-Monitoring; D018592:Cross-Over Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D013315:Stress, Psychological / Q000097:blood*
D001786:Blood Glucose