Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex.
We show that in naïve mice, tonic currents mediated by δ subunit-containing GABA(A) receptors in fast spiking interneurons are larger in females than in males while in regular spiking neurons such a difference was not observed. Moreover, in fast spiking interneurons, associative learning induced a larger reduction of these currents in females than in males. In contrast, in regular spiking neurons, learning similarly enhanced tonic currents in both sexes.
Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, ul.Chalubinskiego 3, 50-367 Wroclaw, Poland.
Joanna
J
Urban-Ciecko
Jerzy W
JW
Mozrzymas
D000818:Animals; D001245:Association Learning / Q000502:physiology; D055724:Electrophysiological Phenomena; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D007395:Interneurons / Q000502:physiology; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D051379:Mice; D009431:Neural Conduction / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D010852:Picrotoxin / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000502:physiology; D012727:Sex Characteristics; D013003:Somatosensory Cortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D018755:GABA Agonists; D018756:GABA Antagonists; D007555:Isoxazoles; D010852:Picrotoxin; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C015542:gaboxadol