[Nocturnal penile tumescence and the effect of tadalafil on erectile dysfunction].
OBJECTIVE
To explore the correlation between the results of the nocturnal penile tumescence (NPT) test and the efficacy of tadalafil in the treatment of ED.


METHODS
A total of 188 ED patients were divided into a normal NPT group (n = 136) and an abnormal NPT group (n = 52) according to the results of the NPT test. All of them were treated with tadalafil at 20 mg 3 times a week. The IIEF-5 score, SEP2, SEP3 and GAQ score were compared between the two groups before and 1 month after the treatment.


RESULTS
Tadalafil treatment significantly improved IIEF-5 score, SEP2 and SEP3 of both groups of the patients (P < 0.01). Compared with the abnormal NPT group, the normal NPT group showed a remarkable increase in the IIEF-5 score, SEP2, SEP3 (P < 0.05) and GAQ score (P < 0.01).


CONCLUSIONS
After 1 month of tadalafil treatment, the normal NPT group achieved a more significant improvement of erectile function and sexual satisfaction than the abnormal NPT group, suggesting that tadalafil has a better therapeutic effect for ED patients with normal NPT.
Department of Urology, Beijing Chuiyangliu Hospital, Beijing 100022, China. drxiaofei@163.com
Fei
F
Xiao
Zhi-An
ZA
Yan
Xian-En
XE
Gu
Wen-Jun
WJ
Bai
Xiao-Feng
XF
Wang
D002243:Carbolines / Q000494:pharmacology / Q000627:therapeutic use*; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D000068581:Tadalafil
D002243:Carbolines; D000068581:Tadalafil