Spatial versus verbal memory impairments in patients with fibromyalgia.
Mounting evidence suggests that individuals with fibromyalgia (FM) have impairments in general cognitive functions. However, few studies have explored the possibility of dissociation between verbal and visuospatial memory impairments in FM. Therefore, the purpose of this study was to investigate the asymmetrical impairment of cognitive functions between verbal and visuospatial memory and between short-term and long-term memory. Neuropsychological assessments were carried out on 23 female patients with FM and 24 healthy female controls. Verbal memory abilities were assessed using the Korean version of the Rey auditory verbal learning test (KAVLT) and digit span task, and visuospatial memory abilities were assessed using the Korean version of the Rey complex figure test (KCFT) and spatial span task. The analysis of covariance was used to assess group differences in performance on cognitive tests after controlling for depression. The two groups did not significantly differ in terms of age, years of education, or in their estimated verbal and performance IQ, but FM patients reported more severe depressive symptoms than did controls on the Beck depression inventory. Significant group differences were found in immediate and delayed recall on the KCFT (F (1,44) = 6.49, p = 0.014 and F (1,44) = 6.96, p = 0.011, respectively), whereas no difference was found in immediate and delayed recall on the KAVLT. In terms of short-term memory, neither the digit span task nor spatial span task showed any difference between groups, regardless of whether repetition was forward or backward. These findings suggest that spatial memory abilities may be more impaired than verbal memory abilities in patients with FM.
Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Korea.
Seong-Ho
SH
Kim
Sang-Hyon
SH
Kim
Seong-Kyu
SK
Kim
Eun Jung
EJ
Nam
Seung Woo
SW
Han
Seung Jae
SJ
Lee
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003071:Cognition; D005260:Female; D005356:Fibromyalgia / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D007361:Intelligence Tests; D008568:Memory; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D057567:Memory, Long-Term; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis; D056910:Republic of Korea; D012720:Severity of Illness Index; D013037:Spatial Behavior; D011795:Surveys and Questionnaires; D013997:Time Factors; D014705:Verbal Behavior
J Rheumatol. 1991 May;18(5):728-33
1865419
Arthritis Rheum. 2005 Nov;52(11):3660-9
16258904
Front Biosci (Landmark Ed). 2009 Jun 01;14:5031-51
19482603
Pain. 2007 Nov;132 Suppl 1:S109-S116
17587497
BMC Musculoskelet Disord. 2007 Mar 09;8:27
17349056
Nat Protoc. 2006;1(2):892-9
17406322
J Clin Rheumatol. 2004 Apr;10(2):53-8
17043464
J Pain. 2009 Jan;10(1):47-52
18771960
Rheumatology (Oxford). 2009 Oct;48(10):1273-8
19654218
J Clin Exp Neuropsychol. 1999 Aug;21(4):477-87
10550807
Arthritis Rheum. 2002 Dec 15;47(6):639-44
12522838
Arthritis Rheum. 2001 Sep;44(9):2125-33
11592377
J Rheumatol. 1995 Jan;22(1):137-42
7699660
Appl Neuropsychol. 2000;7(4):252-8
11296689
Neuron. 2004 Apr 22;42(2):283-95
15091343
Arthritis Rheum. 1990 Feb;33(2):160-72
2306288
J Rheumatol. 2008 Jul;35(7):1371-7
18484688
J Clin Psychiatry. 2008;69 Suppl 2:20-4
18537459
Qual Life Res. 2004 May;13(4):857-61
15129895
Brain. 2008 Dec;131(Pt 12):3222-31
18819988
Rheum Dis Clin North Am. 2009 May;35(2):299-311
19647144
J Psychosom Res. 1997 Mar;42(3):297-306
9130186
J Pain Symptom Manage. 2008 Sep;36(3):259-67
18411013
J Pain Symptom Manage. 2005 Feb;29(2):165-72
15733808
Pain. 2008 Oct 31;139(3):610-616
18691816
J Psychosom Res. 2003 Oct;55(4):321-9
14507543
Semin Arthritis Rheum. 2000 Feb;29(4):217-27
10707990
Arthritis Rheum. 2008 Dec;58(12):3960-9
19035484