[Serological and clinical aspects in initial Wegener's disease. A case report].
The clinical and biochemical features of an acute and initial Wegener's granulomatosis case were analysed in a young woman. A multifactorial aspects are evident. A chronic inflammation of the superior respiratory tract has been observed. Staphylococcus aureus has been isolated. An oligoclonal component constituted of high levels of anti-PR3 autoantibodies was detected: initial autoreactive B cell clone activation is probable. The chronological link with postpartum is present: our study excluded foetal microchimerism; the hormonal state can be a trigger factor. Serical IL-17 was negative.
Laboratorio Analisi, Servizio di Sierologia e Autoimmunità, Ospedale Fatebenefratelli, Milano. caterina.defendenti@fbf.milano.it
Caterina
C
Defendenti
Giacinto
G
Guercilena
Angela
A
Freschi
Anna Maria
AM
Croce
Federica
F
Servida
Silvia
S
Russo
Silvia
S
Grosso
Margherita
M
Longo
Maria Francesca
MF
Spina
Antonio
A
Miadonna
Fabiola
F
Atzeni
Piercarlo
P
Sarzi-Puttini
D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D012698:Serologic Tests