Malondialdehyde levels in dental follicles of asymptomatic impacted third molars.
OBJECTIVE
Increased levels of reactive oxygen species lead to oxidative stress and tissue damage. Malondialdehyde (MDA) is one of many low-molecular-weight endproducts of lipid peroxidation that increases with oxidative stress. The aim of this study was to determine oxidative stress in dental follicles (DFs) of radiologically asymptomatic impacted third molars (ITMs) using MDA.


METHODS
This study involved 40 DFs of 40 patients referred for clinically and radiographically asymptomatic ITMs. Forty healthy gingival tissues in the same patients were obtained during surgical removal of teeth as a control group. DF widths on periapical radiographs narrower than 2.5 mm were included in the study. All tissues samples were analyzed for MDA as an indicator of oxidative stress.


RESULTS
Levels of MDA were significantly higher in DFs from ITMs than those from healthy gingival tissues of the same patients (P < .01).


CONCLUSIONS
The results suggest that significant oxidative stress may occur in DFs of asymptomatic ITMs. The findings suggest that increased MDA may play an important role in oxidative stress in DFs. In light of these preliminary findings of the present study, further investigations and comprehensive studies are required to determine the role of antioxidants that scavenge free radicals in DFs.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Kırıkkale, Ankara, Turkey. umutekin@gmail.com
Umut
U
Tekin
Üçler
Ü
Kısa
Orhan
O
Güven
Hüseyin
H
Kurku
D000293:Adolescent; D000328:Adult; D058070:Asymptomatic Diseases; D003795:Dental Sac / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005881:Gingiva / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis*; D008334:Mandible / Q000378:metabolism / Q000601:surgery; D008964:Molar, Third / Q000378:metabolism* / Q000601:surgery; D018384:Oxidative Stress / Q000502:physiology; D016300:Radiography, Bitewing; D011862:Radiography, Panoramic; D020390:Tooth Socket / Q000378:metabolism / Q000601:surgery; D014095:Tooth, Impacted / Q000378:metabolism* / Q000601:surgery; D055815:Young Adult
D008315:Malondialdehyde