Ultrasonically-promoted synthesis of mandelic acid by phase transfer catalysis in an ionic liquid.
An efficient and facile process to synthesize mandelic acid through phase transfer catalysis (PTC; also phase transfer catalyst) using ultrasound in an ionic liquid has been developed. Mandelic acid was synthesized from benzaldehyde with chloroform in an 89.6% yield at 60°C for 2h by using tetrabutyl ammonium bromide (TBAB) as a phase transfer catalyst. Effects of different factors, such as frequency of ultrasound, reaction temperature, kinds of PTC and solvents had been investigated to obtain the optimum condition. It was observed that the ultrasonically promoted synthesis of mandelic acid by PTC in the ionic liquid exhibited significant enhancement in reaction yields under ambient conditions.
Chemical Engineering School, Nanjing University of Science and Technology, Nanjing, People's Republic of China. jyqianhua@yahoo.com.cn
Qian
Q
Hua
Liu
L
Dabin
Lv
L
Chunxu
D002384:Catalysis / Q000528:radiation effects; D052578:Ionic Liquids / Q000737:chemistry* / Q000528:radiation effects*; D008333:Mandelic Acids / Q000138:chemical synthesis* / Q000528:radiation effects*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*
D052578:Ionic Liquids; D008333:Mandelic Acids; C037938:mandelic acid