Plasma lipoprotein-associated phospholipase A2 in patients with metabolic syndrome and carotid atherosclerosis.
BACKGROUND
Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is a recently identified and potentially useful plasma biomarker for cardiovascular and atherosclerotic diseases. However, the correlation between the Lp-PLA₂ activity and carotid atherosclerosis remains poorly investigated in patients with metabolic syndrome (MetS). The present study aimed to evaluate the potential role of Lp-PLA₂ as a comprehensive marker of metabolic syndrome in individuals with and without carotid atherosclerosis.


METHODS
We documented 118 consecutive patients with MetS and 70 age- and sex-matched healthy subjects served as controls. The patients were further divided into two groups: 39 with carotid plaques and 79 without carotid plaques to elucidate the influence of Lp-PLA₂ on carotid atherosclerosis. The plasma Lp-PLA₂ activity was measured by using ELISA method and carotid intimal-media thickness (IMT) was performed by ultrasound in all participants.


RESULTS
Lp-PLA₂ activity was significantly increased in MetS subgroups when compared with controls, and was higher in patients with carotid plaques than those without plaques (P < 0.05). Furthermore, we found that significant difference in Lp-PLA₂ was obtained between patients with three and four disorders of metabolic syndrome (P < 0.01). Age (β = 0.183, P = 0.029), LDL-cholesterol (β = 0.401, P = 0.000) and waist-hip ratio (β = 0.410, P = 0.000) emerged as significant and independent determinants of Lp-PLA₂ activity. Multiple stepwise regression analysis revealed that LDL-cholesterol (β = 0.309, P = 0.000), systolic blood pressure (β = 0.322, P = 0.002) and age (β = 0.235, P = 0.007) significantly correlated with max IMT, and Lp-PLA2 was not an independent predictor for carotid IMT.


CONCLUSIONS
Lp-PLA₂ may be a modulating factor for carotid IMT via age and LDL-cholesterol, not independent predictor in the pathophysiological process of carotid atherosclerosis in patients with MetS.
Department of Cardiology, the Second hospital of Shandong University, Jinan, Shandong 250033, China.
Hui-Ping
HP
Gong
Yi-Meng
YM
Du
Li-Na
LN
Zhong
Zhao-Qiang
ZQ
Dong
Xin
X
Wang
Yong-Jun
YJ
Mao
Qing-Hua
QH
Lu
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D000368:Aged; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D002340:Carotid Artery Diseases / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D057075:Enzyme Assays; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D012307:Risk Factors; D014463:Ultrasonography
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
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