Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance?
A 58-year-old white woman with stasis dermatitis developed a solitary, slowly growing keratotic nodule of the dorsum of the foot. The excision biopsy specimen of this lesion showed a biphasic pattern of eccrine syringofibroadenoma and clear cell acanthoma. Such a previously unreported association is neither necessarily by chance nor necessarily a collision. Because a reactive histogenesis has been postulated for both eccrine syringofibroadenoma and clear cell acanthoma, this case could represent a morphologically biphasic pattern of epidermal and ductal hyperplasia as a consequence of the stasis-induced chronic inflammation coupled with the footwear-induced chronic trauma.
Dermatopathology Unit, San Gallicano Dermatological Institute, Rome, Italy. cota@ifo.it
Carlo
C
Cota
Gerardo
G
Ferrara
Ada
A
Amantea
Pietro
P
Donati
D049309:Acanthoma / Q000473:pathology*; D006607:Adenoma, Sweat Gland / Q000473:pathology*; D003872:Dermatitis / Q000150:complications; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D005528:Foot / Q000098:blood supply / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology*; D014689:Venous Insufficiency / Q000150:complications