[Detection and identification of the tumor-associated antigens in the fraction enriched with plasma membranes of the Zajdela hepatoma cells].
Tumor-associated antigens 45, 57, 80 and 130 kDa were detected using tumor-specific rabbit immune serum in the fraction enriched with plasma membrane of the rat Zajdela hepatoma cells and isolated on the immunosorbent. Revealed proteins were identified as integrin beta-1, ecto-nucleotide pyrophosphatase/phosphodiesterase-3 (E-NPP3), basigin, epithelial cell adhesion molecule (EpCAM), alpha-fetoprotein (AFP) and protein chaperones--glucose-regulated protein 78 (GRP78) and protein disulfide-isomerase (PDI) A1 by mass spectrometry technique. Functions and characteristics of these proteins in tumor cells and some aspects of the Zajdela hepatoma cells origin are discussed.
N P
NP
Teriukov
O A
OA
Mirgorodskaia
M V
MV
Serebriakova
V A
VA
Ivanov
D000818:Animals; D000951:Antigens, Neoplasm / Q000096:biosynthesis* / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000276:immunology; D011817:Rabbits; D051381:Rats
D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins