A role for SR proteins in plant stress responses.
Members of the SR (serine/arginine-rich) protein gene family are key players in the regulation of alternative splicing, an important means of generating proteome diversity and regulating gene expression. In plants, marked changes in alternative splicing are induced by a wide variety of abiotic stresses, suggesting a role for this highly versatile gene regulation mechanism in the response to environmental cues. In support of this notion, the expression of plant SR proteins is stress-regulated at multiple levels, with environmental signals controlling their own alternative splicing patterns, phosphorylation status and subcellular distribution. Most importantly, functional links between these RNA-binding proteins and plant stress tolerance are beginning to emerge, including a role in the regulation of abscisic acid (ABA) signaling. Future identification of the physiological mRNA targets of plant SR proteins holds much promise for the elucidation of the molecular mechanisms underlying their role in the response to abiotic stress.
Instituto Gulbenkian de Ciência, Oeiras, Portugal. duquep@igc.gulbenkian.pt
Paula
P
Duque
D017398:Alternative Splicing / Q000235:genetics; D009687:Nuclear Proteins / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D000068103:Serine-Arginine Splicing Factors; D013312:Stress, Physiological / Q000235:genetics
D009687:Nuclear Proteins; D010940:Plant Proteins; D016601:RNA-Binding Proteins; D000068103:Serine-Arginine Splicing Factors
Nature. 2008 Apr 17;452(7189):846-50
18322460
Mol Cell. 2008 Apr 25;30(2):179-89
18439897
Mol Biol Cell. 2004 Jul;15(7):3233-43
15133128
Gene. 1987;56(2-3):253-65
3678838
Nucleic Acids Res. 2004 Sep 27;32(17):5096-103
15452276
Plant J. 2000 Jan;21(1):91-6
10652154
Mol Cell. 2004 Nov 19;16(4):597-607
15546619
Plant Physiol. 2010 Oct;154(2):772-83
20699397
J Plant Physiol. 2006 Oct;163(10):1049-60
16376455
Nat Genet. 2008 Dec;40(12):1413-5
18978789
Nature. 2007 Aug 23;448(7156):938-42
17671505
Plant J. 2003 Dec;36(6):883-93
14675452
Plant Mol Biol. 1999 Jul;40(4):719-27
10480395
Theor Appl Genet. 2003 Jul;107(2):326-31
12669200
Mol Cell. 2009 Feb 27;33(4):450-61
19250906
Chromosoma. 2004 Feb;112(5):255-66
14740228
Cell. 1993 Dec 17;75(6):1061-70
8261509
Trends Plant Sci. 2003 Oct;8(10):468-71
14557042
Curr Biol. 1999 Jan 14;9(1):R6-7
9889128
Biochem J. 2009 Jan 1;417(1):15-27
19061484
Plant Cell Physiol. 2007 Jul;48(7):1036-49
17556373
Plant J. 2002 Jun;30(5):511-9
12047626
Plant Cell. 2006 Nov;18(11):3218-34
17114353
New Phytol. 2010 Jan;185(1):83-9
19863731
Proc Natl Acad Sci U S A. 2006 May 2;103(18):7175-80
16632598
Plant Mol Biol. 2000 Mar;42(4):571-81
10809003
Plant J. 2008 Mar;53(6):1035-48
18088312
Mol Cell Biol. 2007 Aug;27(15):5393-402
17526736
Plant J. 2007 Apr;50(1):54-69
17346263
Nature. 2007 Apr 19;446(7138):926-9
17361132
Science. 2001 Sep 7;293(5536):1836-9
11546874
Nat Struct Mol Biol. 2008 Aug;15(8):819-26
18641664
Genes Dev. 2004 Jan 15;18(2):210-22
14752011
Nature. 2010 Feb 11;463(7282):763-8
20148030
Mol Genet Genomics. 2010 Feb;283(2):185-96
20049613
Genes Genet Syst. 2006 Apr;81(2):77-91
16755132
Mol Biol Cell. 2004 Jun;15(6):2664-73
15034145
Plant Cell. 2009 Feb;21(2):642-54
19244141
Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3074-9
8610170
Curr Top Microbiol Immunol. 2008;326:83-102
18630748
J Cell Biol. 1997 Jul 28;138(2):225-38
9230067
Plant Cell. 1996 Dec;8(12):2255-64
8989882
Plant J. 2005 Feb;41(4):567-82
15686520
Mol Cell Biol. 1988 May;8(5):2042-51
3386632
Mol Cell Biol. 2009 Jan;29(1):281-301
18981222
Plant Cell. 2010 Sep;22(9):2926-9
20884799
Nature. 2008 Nov 27;456(7221):470-6
18978772
Trends Biochem Sci. 2005 Mar;30(3):115-8
15752982
EMBO J. 2000 Apr 3;19(7):1625-37
10747030
Nature. 1994 Mar 10;368(6467):119-24
8139654
Mol Cell. 2009 Jul 10;35(1):1-10
19595711
Planta. 2005 Jul;221(5):705-15
15666155
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7672-6
7644475
Genes Dev. 1996 Jul 1;10(13):1569-79
8682289
RNA. 2007 Dec;13(12):2108-15
17959926
PLoS One. 2007 May 30;2(5):e471
17534421
Mol Cell. 2001 Apr;7(4):899-905
11336712
Plant Physiol. 2010 May;153(1):273-84
20237019
J Pathol. 2010 Jan;220(2):152-63
19918805
Plant J. 2007 Mar;49(6):1091-107
17319848
Curr Opin Cell Biol. 2004 Jun;16(3):279-84
15145352
Plant Mol Biol. 1999 Mar;39(4):761-73
10350090
Mol Biol Evol. 2006 May;23(5):1085-94
16520337
Mol Cell. 2004 Feb 13;13(3):367-76
14967144
Mol Cell. 2004 Nov 5;16(3):363-73
15525510
Exp Cell Res. 2008 Oct 15;314(17):3175-86
18674533
Nucleic Acids Res. 1996 Jun 15;24(12):2347-51
8710506
EMBO J. 2001 Sep 3;20(17):4987-97
11532962
Curr Top Microbiol Immunol. 2008;326:257-75
18630757
J Biol Chem. 2000 Mar 17;275(11):7950-7
10713112
Mol Cell. 2003 Mar;11(3):837-43
12667464
J Cell Biol. 1999 Jun 14;145(6):1145-52
10366588
Biochem Cell Biol. 1999;77(4):293-8
10546892
J Biol Chem. 2002 Oct 18;277(42):39989-98
12176998
Biochem Soc Trans. 2004 Aug;32(Pt 4):561-4
15270675
Plant J. 2004 Sep;39(6):877-85
15341630
Plant Mol Biol. 1986 Sep;6(5):347-57
24307385
Plant Cell Rep. 2007 Jan;26(1):105-13
17021849
Plant Cell Rep. 2004 Sep;23(3):159-66
15138696
Plant Physiol. 2007 Mar;143(3):1086-95
17220363
Annu Rev Plant Biol. 2007;58:267-94
17222076
Cell. 2005 Aug 12;122(3):365-78
16096057
Genome Res. 2010 Jan;20(1):45-58
19858364
Nat Genet. 2003 Jun;34(2):177-80
12730695
RNA. 2000 Sep;6(9):1197-211
10999598
J Integr Plant Biol. 2009 Mar;51(3):287-98
19261072
Mol Cell. 2005 Nov 23;20(4):499-501
16307914
Mol Cell. 2005 Mar 4;17(5):613-5
15749011
J Biol Chem. 2007 Jul 6;282(27):19844-53
17513303
EMBO J. 2007 Jan 24;26(2):459-67
17183366
Plant Cell. 2006 Jan;18(1):146-58
16339852
Prog Nucleic Acid Res Mol Biol. 2004;78:37-88
15210328
Curr Top Microbiol Immunol. 2008;326:119-38
18630750
Curr Top Microbiol Immunol. 2008;326:103-18
18630749
Genes Dev. 2004 Apr 1;18(7):755-68
15082528
Mol Biol Cell. 2003 Sep;14(9):3565-77
12972547
Genes Dev. 1999 Apr 15;13(8):987-1001
10215626
J Biol Chem. 1999 Dec 17;274(51):36428-38
10593939
Genes Dev. 2010 Jun 1;24(11):1073-4
20516191
Plant Cell. 1998 Oct;10(10):1637-48
9761791