Olive oil-based fat emulsion versus soy oil-based fat emulsion in abdominal oncologic surgery.
In parenteral nutrition (PN), essential fatty acids are provided by soy oil-based fat emulsions, which may exert adverse effects on the immune system and lipid peroxidation. Olive oil -based fat emulsions have been said to prevent these undesired effects. This study compares effects of olive oil - and soy oil -based fat emulsions in 22 patients who underwent abdominal surgery for cancer. The first group (n = 10) received soy oil -based fat emulsion; the second group (n = 10) received olive oil -based fat emulsion. Body temperature, body mass index, (BMI) and biochemical variables were measured on days 0 and 7. There were no differences between the groups with regard to BMI or temperature. On day 7, the first group (compared with day 0) had significant increases in plasma alkaline phosphatase (81.70 ± 16.03 vs 117.60 ± 11.1), γ-glutamyl transferase (39.90 ± 15.40 vs 137.70 ± 24.09), and mean body temperature (36.72°C ± 0.14°C vs 37.20°C ± 0.17°C) (P < .01). Second group had increases in alkaline phosphatase (85.80 ± 13.46 vs 147.20 ± 34.17), γ-glutamyl transferase (48.40 ± 12.86 vs 129.40 ± 42.03), total protein (5.14 ± 0.19 vs 6.06 ± 0.49), and albumin (2.62 ± 0.14 vs 3.00 ± 0.18) (P < .05). Changes in thiobutyric acid levels were not statistically significant in either group. In postoperative cancer patients, olive oil-based fat emulsion had similar effects on BMI, body temperature, biochemical values, and thiobutyric acid levels as soy oil-based fat emulsions.
Hacettepe University Faculty of Medicine, Nutrition and Dietetic Department, Ankara, Turkey.
Pelin
P
Onar
Baris Dogu
BD
Yildiz
Emine Akal
EA
Yildiz
Tanju
T
Besler
Osman
O
Abbasoglu
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D001831:Body Temperature; D002087:Butyrates / Q000097:blood; D016022:Case-Control Studies; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000628:therapy*; D000069463:Olive Oil; D010288:Parenteral Nutrition; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D016037:Single-Blind Method; D013024:Soybean Oil / Q000494:pharmacology* / Q000627:therapeutic use; D014166:Transferases / Q000097:blood
D015415:Biomarkers; D002087:Butyrates; D005217:Fat Emulsions, Intravenous; D000069463:Olive Oil; D010938:Plant Oils; D013024:Soybean Oil; D014166:Transferases; D000469:Alkaline Phosphatase