Current perspectives on Mycobacterium avium subsp. paratuberculosis, Johne's disease, and Crohn's disease: a review.
Mycobacterium avium subsp. paratuberculosis (MAP) causes the disease of cattle, Johne's. The economic impact of this disease includes early culling of infected cattle, reduced milk yield, and weight loss of cattle sold for slaughter. There is a possible link between MAP and Crohn's disease, a human inflammatory bowel disease. MAP is also a potential human food borne pathogen because it survives current pasteurization treatments. We review the current knowledge of MAP, Johne's disease and Crohn's disease and note directions for future work with this organism including rapid and economical detection, effective management plans and preventative measures.
Center for Food Safety and Food Science Department, University of Arkansas, 2650 N. Young Ave., Fayetteville, AR 72704, USA.
Ken
K
Over
Philip G
PG
Crandall
Corliss A
CA
O'Bryan
Steven C
SC
Ricke
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D016927:Mycobacterium avium subsp. paratuberculosis / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D010283:Paratuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission