Diagnostic value of the neutrophil myeloperoxidase index in horses with systemic inflammation.
The myeloperoxidase index (MPXI) was investigated as a diagnostic indicator of systemic inflammation in a retrospective study using data from 859 hospitalised horses. A reference interval of 8.5-10.4 for the MPXI was established. In horses with systemic inflammatory response syndrome (SIRS), the MPXI was significantly lower than in healthy horses, those with localised inflammation and those with sepsis. The MPXI in horses with sepsis was also significantly lower than in healthy animals and those with localised inflammation. Horses in the SIRS group with leucopenia, white blood cell (WBC) count within the reference interval (WRI) or leucocytosis had significantly lower MPXIs than healthy horses, those with localised inflammation and those with sepsis in the same WBC count subgroups. In horses with sepsis and WBC count WRI, the MPXI was significantly lower than in healthy horses or those with localised inflammation. MPXI is a useful complementary tool to identify horses with systemic inflammation, especially if they have WBC counts WRI.
Equine Hospital, Section Internal Medicine, Department for Small Animals and Horses, Vetmeduni Vienna, Veterinärplatz 1, 1210 Vienna, Austria. bianca.schwarz@vetmeduni.ac.at
Bianca C
BC
Schwarz
René
R
van den Hoven
Ilse
I
Schwendenwein
D000818:Animals; D005260:Female; D006734:Horse Diseases / Q000097:blood / Q000175:diagnosis*; D006736:Horses; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018805:Sepsis / Q000175:diagnosis / Q000662:veterinary; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000662:veterinary*
D009195:Peroxidase