Influence of experimental esophageal acidification on sleep bruxism: a randomized trial.
The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy adult males without SB participated. Intra-esophageal infusions of 5-mL acidic solution (0.1 N HCl) or saline were administered. The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-minute period after acidic infusion than after saline infusion. RMMA episodes including SB were induced by esophageal acidification. This trial is registered with the UMIN Clinical Trials Registry, UMIN000002923.


BACKGROUND
ASDA, American Sleep Disorders Association; EMG, electromyogram; GER, gastroesophageal reflux; LES, lower esophageal sphincter; NREM, non-rapid eye movement; REM, rapid eye movement; RMMA, rhythmic masticatory muscle activity; SB, sleep bruxism; SD, standard deviation; UES, upper esophageal sphincter.
Department of Orthodontics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.
H
H
Ohmure
K
K
Oikawa
K
K
Kanematsu
Y
Y
Saito
T
T
Yamamoto
H
H
Nagahama
H
H
Tsubouchi
S
S
Miyawaki
D000287:Administration, Topical; D000328:Adult; D001143:Arousal; D018592:Cross-Over Studies; D003679:Deglutition; D004576:Electromyography; D049630:Esophageal Sphincter, Lower / Q000187:drug effects; D049631:Esophageal Sphincter, Upper / Q000187:drug effects; D004947:Esophagus / Q000187:drug effects*; D005744:Gastric Acid / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D006851:Hydrochloric Acid / Q000008:administration & dosage / Q000009:adverse effects*; D006863:Hydrogen-Ion Concentration; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects / Q000502:physiology; D016037:Single-Blind Method; D020186:Sleep Bruxism / Q000209:etiology*; D018709:Statistics, Nonparametric; D055815:Young Adult
D006851:Hydrochloric Acid