Hyperadiponectinemia enhances bone formation in mice.
BACKGROUND
There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone development remains controversial.


METHODS
We therefore investigated the endocrine effects of adiponectin on bone metabolism using 12-week-old male transgenic (Ad-Tg) mice with significant hyperadiponectinemia overexpressing human full-length adiponectin in the liver.


RESULTS
In Ad-Tg mice, the serum level of osteocalcin was significantly increased, but the levels of RANKL, osteoprotegerin, and TRAP5b were not. Bone mass was significantly greater in Ad-Tg mice with increased bone formation. In contrast, bone resorption parameters including the number of osteoclasts and eroded surface area did not differ between Ad-Tg and their littermates.


CONCLUSIONS
These findings demonstrate that hyperadiponectinemia enhances bone formation in mice.
Department of Orthopedic Surgery, Kurume University, Kurume, Fukuoka, Japan.
Yasuhiro
Y
Mitsui
Masafumi
M
Gotoh
Nobuhiro
N
Fukushima
Isao
I
Shirachi
Shuichi
S
Otabe
Xiaohong
X
Yuan
Toshihiko
T
Hashinaga
Nobuhiko
N
Wada
Akiko
A
Mitsui
Tatsuhiro
T
Yoshida
Shiro
S
Yoshida
Kentaro
K
Yamada
Kensei
K
Nagata
D052242:Adiponectin / Q000235:genetics / Q000502:physiology; D000818:Animals; D001846:Bone Development / Q000502:physiology*; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic
C499918:ADIPOQ protein, human; D052242:Adiponectin
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