Synthesis of 2,4-diiodoquinolines via the photochemical cyclization of o-alkynylaryl isocyanides with iodine.
Upon photoirradiation of o-alkynylaryl isocyanides in the presence of iodine, the intramolecular cyclization of o-alkynylaryl isocyanides proceeds to afford the corresponding 2,4-diiodoquinolines in good yields. 2,4-Diiodoquinolines can be employed in transition metal-catalyzed cross-coupling reactions.
Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Takenori
T
Mitamura
Akiya
A
Ogawa
D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010777:Photochemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
C571788:2,4-diiodoquinoline; D003486:Cyanides; D006847:Hydrocarbons, Iodinated; D011804:Quinolines; D007455:Iodine