Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelet syndrome.
BACKGROUND
Sticky platelet syndrome is an autosomal-dominant thrombophilia characterized by platelet hyperaggregability in the presence of adenosine diphosphate or epinephrine. The result clinically can be widespread thromboses, often arterial, in patients without apparent risk factors for thrombotic disease. Limited data exist regarding its role in adverse pregnancy outcomes.


METHODS
A gravid woman with two previous first-trimester miscarriages presented at 11 weeks of gestation with a deep venous thrombosis. Despite anticoagulation, she developed extensive and progressive arterial and venous thromboses and suffered a fetal demise. A thrombophilia panel was unremarkable, but platelet aggregometry demonstrated hyperactive platelets in the presence of adenosine diphosphate and epinephrine consistent with sticky platelet syndrome.


CONCLUSIONS
Sticky platelet syndrome causes arterial thromboses and may be an underappreciated etiology for adverse pregnancy outcomes.
From the University of Texas Southwestern Medical Center, Dallas, Texas; and the Department of Obstetrics and Gynecology, Parkland Health and Hospital System, Dallas, Texas.
Martha W F
MWF
Rac
Natalie
N
Minns Crawford
Kevin C
KC
Worley
D000005:Abdomen / Q000000981:diagnostic imaging; D000925:Anticoagulants / Q000627:therapeutic use; D001791:Blood Platelet Disorders / Q000150:complications* / Q000188:drug therapy; D004107:Dilatation and Curettage; D017128:Embolectomy; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D007866:Leg / Q000098:blood supply / Q000000981:diagnostic imaging; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011860:Radiography, Abdominal; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000209:etiology
D000925:Anticoagulants
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