New synthetic route to N-tocopherol derivatives: synthesis of pyrrolopyridinol analogue of α-tocopherol from pyridoxine.
A new synthetic route to pyrrolopyridinol antioxidants from easily accessible pyridoxine was developed which includes phase-transfer catalytic alkylation and intramolecular Cu(I)-catalyzed amination as key steps.
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA.
Tae-gyu
TG
Nam
Jin-Mo
JM
Ku
Hyeung-geun
HG
Park
Ned A
NA
Porter
Byeong-Seon
BS
Jeong
D006900:Hydroxylation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011736:Pyridoxine / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D011725:Pyridines; D011758:Pyrroles; D024502:alpha-Tocopherol; D011736:Pyridoxine