[GABA B-type receptors: structure and functions].
Available data on structure, localization, physiology and pharmacology of GABAB-type receptors are reviewed. GABAB-receptors are pre- and postsynaptically located, belong to metabotropic ones and are connected to trimeric G-protein. Mammal GABAB-receptors, consisting of two subunits of B1 and B2 type, are allosterically regulated heterodimers (actively functioning GABAB-receptors). The activation of GABAB-type receptors leads to increasing K+ release from the cell and hyperpolarization of cell membrane. GABAB-receptors are also connected with potentially dependent Ca2+ channels, which are involved in the synaptic release of neurotransmitters. There is a great number of their allosteric modulators, agonists and antagonists.
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Perfilova
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Tiurenkov
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D021122:Protein Subunits / Q000378:metabolism; D018080:Receptors, GABA-B / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
D015220:Calcium Channels; D021122:Protein Subunits; D018080:Receptors, GABA-B; D011188:Potassium