HID-1 is a novel player in the regulation of neuropeptide sorting.
Peptide hormones and neuropeptides are packaged and stored in a specialized intracellular organelle called the dense core vesicle. It remains elusive how peptide cargoes are correctly sorted. In the present study, we show that a highly conserved Golgi-localized protein named HID-1 acts to prevent mis-sorting of peptide cargoes to lysosomes for degradation via a PtdIns3P-dependent trafficking pathway. Epistasis analysis suggests that rab-2 is epistatic to hid-1.
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Yong
Y
Yu
Lifen
L
Wang
Yaming
Y
Jiu
Yi
Y
Zhan
Lin
L
Liu
Zhiping
Z
Xia
Eli
E
Song
Pingyong
P
Xu
Tao
T
Xu
D000818:Animals; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005089:Exocytosis; D006056:Golgi Apparatus / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D009154:Mutation; D009479:Neuropeptides / Q000378:metabolism*; D021381:Protein Transport; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000235:genetics / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; C557719:HID-1 protein, C elegans; D008562:Membrane Glycoproteins; D009479:Neuropeptides; D033921:Vesicular Transport Proteins; C418215:IDA-1 protein, C elegans; D017027:Protein Tyrosine Phosphatases