Highly enantioselective synthesis of syn-aldols of cyclohexanones via chiral primary amine catalyzed asymmetric transfer aldol reactions in ionic liquid.
Chiral primary-tertiary diamine/TfOH was found to catalyze kinetic resolution of racemic syn-aldols of cyclohexanones in ionic liquid effectively, affording the chiral syn-aldols with up to 99:1 syn/anti and 99% ee.
Department of Chemistry and State Key Laboratory of Elemental-Organic Chemistry, Nankai University, Tianjin, 300071, China.
Pengxin
P
Zhou
Sanzhong
S
Luo
Jin-Pei
JP
Cheng