Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance.
We studied the correlation between the effect of α-lipoic acid, emoxipin, reamberin, and mexidol on LPO in vitro and the action of these drugs on insulin sensitivity and tolerance to glucose load in vivo. It was found that the preparations producing prooxidant effect in vitro (α-lipoic acid and reamberin) are characterized by pronounced insulin-potentiating activity, but only slightly increase (α-lipoic acid) or even decrease (reamberin) tolerance to glucose load. 3-Hydroxypyridine derivatives (emoxipin and mexidol) producing an antioxidant effect in vitro increase glucose tolerance, but exhibit relatively weak insulin-potentiating activity. These results suggest that differential use of the studied drugs in patients with diabetes mellitus depending on the type of the disease and individual insulin requirement is a promising trend in medical studies.
Department of Pharmacology, Chelyabinsk State Medical Academy, Russia. volcheg@yandex.ru
I A
IA
Volchegorskii
L M
LM
Rassokhina
I Yu
IY
Miroshnichenko
K M
KM
Mester
P N
PN
Novoselov
T V
TV
Astakhova
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D007333:Insulin Resistance; D015227:Lipid Peroxidation / Q000187:drug effects*; D008536:Meglumine / Q000031:analogs & derivatives; D010847:Picolines; D051381:Rats; D017382:Reactive Oxygen Species / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D013386:Succinates; D008063:Thioctic Acid
D000975:Antioxidants; D001786:Blood Glucose; D010847:Picolines; D017382:Reactive Oxygen Species; C549374:Reamberin; D013386:Succinates; C070020:emoxypine succinate; D008536:Meglumine; D008063:Thioctic Acid; C009820:6-methyl-2-ethyl-3-hydroxypyridine