Relationship between interleukin-6 and cerebral deep white matter and periventricular hyperintensity in elderly women.
OBJECTIVE
We evaluated the relationships between serum levels of high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6 with the severity of leukoaraiosis.


METHODS
One hundred and thirty-seven elderly women who attended the Center for Comprehensive Care on Memory Disorders at Kyorin University Hospital were enrolled in this study. Leukoaraiosis was assessed by periventricular hyperintensity (PVH) score and deep white matter hyperintensity (DWMH) score.


RESULTS
Serum log IL-6 level correlated with PVH and DWMH scores, but hsCRP did not. By multinomial logistic analysis, IL-6 was significantly related to DWMH score, independent of age and systolic blood pressure.


CONCLUSIONS
IL-6 is presumably an important marker of leukoaraiosis, as is the case with silent cerebral infarction.
Department of Geriatric Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan. kozaki-tky@umin.ac.jp
Kumiko
K
Nagai
Koichi
K
Kozaki
Kazuki
K
Sonohara
Masahiro
M
Akishita
Kenji
K
Toba
D000368:Aged; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000473:pathology*; D002097:C-Reactive Protein / Q000032:analysis; D002544:Cerebral Infarction / Q000175:diagnosis; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D049292:Leukoaraiosis / Q000097:blood* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging
D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein