Serum 25-hydroxyvitamin D and risks of colon and rectal cancer in Finnish men.
Prospective investigations of circulating vitamin D concentrations suggest inverse associations with colorectal cancer risk, although inconsistencies remain and few studies have examined the impact of season. The authors conducted a prospective case-control study of 239 colon cancer cases and 192 rectal cancer cases (diagnosed in 1993-2005) and 428 controls matched on age and blood collection date within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a cohort study of Finnish male smokers. Baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations were categorized using a priori defined cutpoints of <25, 25-<37.5, 37.5-<50, 50-<75, and ≥75 nmol/L and by season-specific and season-standardized 25(OH)D quartiles. Conditional logistic regression models yielded multivariate-adjusted odds ratios for the predefined cutpoints of 0.63, 0.91, 0.73, 1.00 (referent), and 1.44 for colon cancer and 0.64, 0.58, 0.84, 1.00, and 0.76 for rectal cancer, respectively (all 95% confidence intervals included 1.00). Colon cancer risks were significantly elevated for the highest season-specific and season-standardized quartiles versus the lowest quartiles (OR = 2.11 (95% CI: 1.20, 3.69) and OR = 1.88 (95% CI: 1.07, 3.28), respectively), while rectal cancer risk estimates were null. These results provide no evidence to support an inverse association between vitamin D status and colon or rectal cancer risk; instead, they suggest a positive association for colon cancer.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. weinstes@mail.nih.gov
Stephanie J
SJ
Weinstein
Kai
K
Yu
Ronald L
RL
Horst
Jason
J
Ashby
Jarmo
J
Virtamo
Demetrius
D
Albanes
D000230:Adenocarcinoma / Q000097:blood* / Q000175:diagnosis / Q000517:prevention & control; D000368:Aged; D016588:Anticarcinogenic Agents / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000517:prevention & control; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012004:Rectal Neoplasms / Q000097:blood; D018570:Risk Assessment; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D016588:Anticarcinogenic Agents; D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):927-31
20332255
Cancer Res. 2009 Feb 15;69(4):1439-47
19208842
Am J Epidemiol. 2010 Jul 1;172(1):70-80
20562186
MMWR Morb Mortal Wkly Rep. 2008 Nov 14;57(45):1221-6
19008790
Am J Clin Nutr. 2007 Jun;85(6):1586-91
17556697
BMJ. 2003 Mar 1;326(7387):469
12609940
Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):403-12
10794485
Acta Oncol. 2002;41(4):381-8
12234031
Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1502-8
15342452
Am J Epidemiol. 2010 Jul 1;172(1):47-57
20562187
Annu Rev Nutr. 2009;29:111-32
19400699
Stat Med. 2003 May 15;22(9):1477-93
12704611
Cancer Causes Control. 2004 Apr;15(3):255-65
15090720
Nutr Cancer. 2009;61(1):47-69
19116875
Am J Prev Med. 2007 Mar;32(3):210-6
17296473
J Clin Oncol. 2008 Jun 20;26(18):2984-91
18565885
Am J Epidemiol. 1995 Sep 15;142(6):608-11
7653469
Am J Clin Nutr. 2008 Dec;88(6):1519-27
19064511
Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):130-4
20056631
J Natl Cancer Inst. 2007 Jul 18;99(14):1120-9
17623801
N Engl J Med. 2006 Feb 16;354(7):684-96
16481636
Am J Epidemiol. 2010 Jul 1;172(1):58-69
20562184
Eur J Cancer Prev. 2009 Nov;18(6):458-75
19730382
Ann Epidemiol. 2009 Feb;19(2):73-8
18329892
N Engl J Med. 2007 Jul 19;357(3):266-81
17634462
Am J Epidemiol. 2010 Jul 1;172(1):36-46
20562189
Am J Epidemiol. 2010 Jul 1;172(1):94-106
20562192
Int J Cancer. 2011 Mar 15;128(6):1414-24
20473927
Cancer Res. 2006 Oct 15;66(20):10213-9
17047087
Clin Biochem. 2009 Oct;42(15):1549-56
19631201
Am J Epidemiol. 2010 Jul 1;172(1):81-93
20562185
Cancer Causes Control. 1997 Jul;8(4):615-25
9242478
Science. 2002 May 17;296(5571):1313-6
12016314
Br J Cancer. 2007 Aug 6;97(3):446-51
17622244
Am J Epidemiol. 2009 Jul 1;170(1):88-94
19406919
J Natl Cancer Inst. 2007 Nov 7;99(21):1594-602
17971526
BMJ. 2010 Jan 21;340:b5500
20093284
Bone. 2002 May;30(5):771-7
11996918
Int J Epidemiol. 1980 Sep;9(3):227-31
7440046
Lancet. 1989 Nov 18;2(8673):1176-8
2572900
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1889-93
17855710
Am J Epidemiol. 2010 Apr 15;171(8):903-8
20219763
Am J Epidemiol. 2010 Jul 1;172(1):10-20
20562188
Ann Epidemiol. 1994 Jan;4(1):1-10
8205268
Int J Biometeorol. 2000 Nov;44(4):186-9
11131290
J Bone Miner Res. 2007 Dec;22 Suppl 2:V81-5
18290728
Br J Cancer. 2007 Jul 2;97(1):123-8
17551495
Am J Clin Nutr. 2004 Mar;79(3):362-71
14985208