The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.
Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland.
Kevin S
KS
Eccles
Rebecca E
RE
Deasy
László
L
Fábián
Anita R
AR
Maguire
Simon E
SE
Lawrence
D002087:Butyrates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D012492:Salts / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D002087:Butyrates; D012492:Salts; D012996:Solutions