Ruthenium-catalyzed oxidative vinylation of heteroarene carboxylic acids with alkenes via regioselective C-H bond cleavage.
The ruthenium-catalyzed oxidative vinylation of thiophene-2-carboxylic acids with alkenes efficiently proceeds through directed C-H bond cleavage to give the corresponding 3-vinylated products. Similarly, benzothiophene-, benzofuran-, pyrrole-, and indolecarboxylic acids also undergo regioselective vinylation.
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Takumi
T
Ueyama
Satoshi
S
Mochida
Tatsuya
T
Fukutani
Koji
K
Hirano
Tetsuya
T
Satoh
Masahiro
M
Miura