Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents.
The successful marriage of structural features from our 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilm modulators. The compounds were evaluated against a panel of four bacterial strains for anti-biofilm and anti-microbial activity.
Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Steven A
SA
Rogers
Erick A
EA
Lindsey
Daniel C
DC
Whitehead
Trey
T
Mullikin
Christian
C
Melander
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D002219:Carbamates / Q000737:chemistry*; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis; D007093:Imidazoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D012756:Sheep
D000890:Anti-Infective Agents; D002219:Carbamates; D007093:Imidazoles; C014973:2-aminoimidazole