[Activity of the hypothalamic-pituitary-adrenal axis in patients with rheumatoid arthritis].
The controlled data accumulated so far support only subtle alterations in hypothalamic-pituitary-adrenal (HPA) axis function in rheumatoid arthritis (RA), mainly at the adrenal level, and particularly in a subset of premenopausal onset women. Consequences of the subtle HPA alterations in RA for the disease development remain unclear. From a broader perspective, the unresponsiveness of the HPA axis to chronic inflammation in RA can be simply considered an ongoing adaptation to chronic disease.
Molekulárno-medicínske centrum SAV, Ustav experimentálnej endokrinológie SAV Bratislava, Slovenská republika. richard.imrich@savba.sk
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D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology*