An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity.
This work develops an electrochemical approach for rapid detection of the genomic DNA methylation level, assay of methyltransferase activity, and evaluation and screening of the inhibitors of methyltransferase. This method may be a help for the discovery of anticancer drugs.
Jiangsu Key Laboratory of Power Batteries, Laboratory of Electrochemistry, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China.
Shuna
S
Liu
Ping
P
Wu
Wen
W
Li
Hui
H
Zhang
Chenxin
C
Cai
D001483:Base Sequence; D018899:CpG Islands; D004247:DNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D019175:DNA Methylation; D004563:Electrochemistry / Q000379:methods*; D057075:Enzyme Assays / Q000379:methods*; D008780:Methyltransferases / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D013997:Time Factors
D004247:DNA; D008780:Methyltransferases