New developments in pancreatic cancer.
Pancreatic adenocarcinoma presents in an advanced stage and has a dismal prognosis. Extensive recent research efforts have provided us with greater insight into the etiology of pancreatic cancer and have also improved our means of prognostication. Molecular analysis demonstrated that specific pathways involved in pancreatic carcinogenesis are perhaps more valuable to study than single genetic aberrations. Previous risk factors, including family history, body mass index, and current cigarette smoking, were validated and novel risks, such as ABO blood group alleles, were identified. Similar to other illnesses, combinations of healthful habits, such as not smoking, adhering to a Mediterranean dietary pattern, and engaging in physical activity, may decrease pancreatic cancer risk. Finally, CA 19-9 levels, the presence of diabetes mellitus, and a six-gene signature provided critical information regarding survival that could help guide treatment of individuals diagnosed with pancreatic adenocarcinoma.
Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Medical Arts Building, 3708 Fifth Avenue, Fourth Floor, Pittsburgh, PA 15213, USA. greerjb@upmc.edu
Julia B
JB
Greer
Randall E
RE
Brand
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D050154:Adiposity; D000428:Alcohol Drinking; D001789:Blood Group Antigens; D015992:Body Mass Index; D018395:CA-19-9 Antigen / Q000378:metabolism; D004032:Diet; D000076164:Fanconi Anemia Complementation Group N Protein; D005492:Folic Acid; D040941:Heredity; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking; D025521:Tumor Suppressor Proteins / Q000235:genetics; D014807:Vitamin D
D001789:Blood Group Antigens; D018395:CA-19-9 Antigen; D000076164:Fanconi Anemia Complementation Group N Protein; D009687:Nuclear Proteins; C512790:PALB2 protein, human; D025521:Tumor Suppressor Proteins; D014807:Vitamin D; D005492:Folic Acid
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