Metal-free intramolecular amination: one-pot tandem synthesis of 3-substituted 4-quinolones.
3-Substituted 4-quinolones were synthesized using a one-pot metal-free strategy in moderate to quantitative yields. Carried out in dimethylsulfoxide (DMSO) via a sequential addition of materials, the methodology is tolerant of a wide range of functional groups and applicable to library synthesis.
Soochow University, Suzhou, PR China.
Qi-Lun
QL
Liu
Qiu-Lian
QL
Li
Xiang-Dong
XD
Fei
Yong-Ming
YM
Zhu
D000586:Amination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015363:Quinolones / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D015363:Quinolones