Dispersed activity during passive movement in the globus pallidus of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated primate.
Parkinson's disease is a neurodegenerative disorder manifesting in debilitating motor symptoms. This disorder is characterized by abnormal activity throughout the cortico-basal ganglia loop at both the single neuron and network levels. Previous neurophysiological studies have suggested that the encoding of movement in the parkinsonian state involves correlated activity and synchronized firing patterns. In this study, we used multi-electrode recordings to directly explore the activity of neurons from the globus pallidus of parkinsonian primates during passive limb movements and to determine the extent to which they interact and synchronize. The vast majority (80/103) of the recorded pallidal neurons responded to periodic flexion-extension movements of the elbow. The response pattern was sinusoidal-like and the timing of the peak response of the neurons was uniformly distributed around the movement cycle. The interaction between the neuronal activities was analyzed for 123 simultaneously recorded pairs of neurons. Movement-based signal correlation values were diverse and their mean was not significantly different from zero, demonstrating that the neurons were not activated synchronously in response to movement. Additionally, the difference in the peak responses phase of pairs of neurons was uniformly distributed, showing their independent firing relative to the movement cycle. Our results indicate that despite the widely distributed activity in the globus pallidus of the parkinsonian primate, movement encoding is dispersed and independent rather than correlated and synchronized, thus contradicting current views that posit synchronous activation during Parkinson's disease.
Gonda Brain Research Center, Bar Ilan University, Ramat Gan, Israel.
Yaara
Y
Erez
Hadass
H
Tischler
Katya
K
Belelovsky
Izhar
I
Bar-Gad
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000200:Action Potentials; D000818:Animals; D005917:Globus Pallidus / Q000503:physiopathology*; D009068:Movement; D009474:Neurons; D009498:Neurotoxins; D010300:Parkinson Disease / Q000503:physiopathology*; D011323:Primates
D009498:Neurotoxins; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
J Neurophysiol. 1994 Aug;72(2):507-20
7983515
J Neurosci. 2000 Nov 15;20(22):8559-71
11069964
Brain Res. 2003 Nov 14;990(1-2):38-44
14568327
J Neurosci. 2002 Sep 15;22(18):7850-5
12223537
J Neurosci. 2003 Mar 1;23(5):1916-23
12629196
Annu Rev Neurosci. 1986;9:357-81
3085570
J Neurosci. 2000 Oct 15;20(20):7766-75
11027240
J Neurophysiol. 1985 Feb;53(2):530-43
3981228
J Neurophysiol. 1990 Dec;64(6):1892-906
2074471
J Neurosurg. 1996 Dec;85(6):1005-12
8929488
J Neurosurg. 1998 Jun;88(6):1027-43
9609298
J Neurophysiol. 2000 Mar;83(3):1760-3
10712496
J Comp Neurol. 1984 Jan 10;222(2):265-300
6365984
Exp Neurol. 2010 Apr;222(2):219-25
20059997
J Neurophysiol. 1971 May;34(3):414-27
4997823
J Neurophysiol. 1997 Mar;77(3):1051-74
9084582
J Neurophysiol. 2001 Feb;85(2):998-1004
11160530
Prog Neurobiol. 1996 Nov;50(4):381-425
9004351
J Neurosci. 2002 Apr 1;22(7):2855-61
11923450
J Physiol. 1980 Apr;301:439-55
7411442
J Neurosci. 2009 Jun 17;29(24):7797-802
19535591
Ann Neurol. 1994 May;35(5):586-91
8179304
Arch Neurol. 2007 Jan;64(1):20-4
17210805
Eur J Neurosci. 2006 Aug;24(4):1201-8
16930445
Brain Res. 1988 Mar 15;444(1):165-76
3359286
J Neurosci. 2005 Feb 9;25(6):1523-31
15703406
J Neurosci. 2006 Mar 29;26(13):3567-83
16571765