Wnt signaling during synaptic development and plasticity.
The formation of synaptic connections requires a dialogue between pre and postsynaptic cells to coordinate the assembly of the presynaptic release machinery and the postsynaptic receptive complexes. Signaling molecules of the Wnt family of proteins are central to this trans-synaptic dialogue. At the neuromuscular junction and central synapses, Wnts promote synaptic assembly by signaling to the developing pre and postsynaptic compartments. In addition, new studies reveal that expression of Wnt proteins and localization of their Fz receptors are regulated by neuronal activity. Importantly, Wnts mediates the synaptic changes induced by patterned neuronal activity or sensory experience in mature neurons. Here we review recent findings into the function of Wnt signaling at the synapse and its link to activity-dependent synaptic growth and function.
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA. vivian.budnik@umassmed.edu
Vivian
V
Budnik
Patricia C
PC
Salinas
D000818:Animals; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*
D051153:Wnt Proteins
Neuron. 2008 Mar 13;57(5):705-18
18341991
J Biol Chem. 2009 Jun 5;284(23):15857-66
19332546
Trends Neurosci. 2010 Feb;33(2):84-92
20004982
Cell. 2007 Aug 24;130(4):704-16
17719547
Development. 2010 Apr;137(7):1017-33
20215342
Dev Neurobiol. 2008 Feb 1;68(2):152-65
17963254
Neuron. 2002 Aug 1;35(3):489-505
12165471
J Neurosci. 1999 Oct 15;19(20):8894-908
10516309
Cell. 2000 Mar 3;100(5):525-35
10721990
Nat Rev Neurosci. 2009 Sep;10(9):627-34
19693027
Mol Cell Neurosci. 2007 Aug;35(4):513-24
17588772
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18812-7
19020093
J Neurosci. 2010 Jun 23;30(25):8411-20
20573888
Proc Natl Acad Sci U S A. 2006 May 16;103(20):7841-6
16682643
Neuron. 2000 May;26(2):371-82
10839356
Neuron. 2009 Mar 12;61(5):721-33
19285469
Nature. 2001 Apr 26;410(6832):1057-64
11323662
Neuroscience. 2002;115(2):505-13
12421617
J Cell Biol. 2004 Jan 19;164(2):243-53
14734535
Curr Opin Neurobiol. 2007 Feb;17(1):35-42
17229568
J Biol Chem. 2006 Apr 28;281(17):11910-6
16501258
Neuron. 2009 May 28;62(4):510-25
19477153
Science. 2005 Nov 25;310(5752):1344-7
16311339
J Neurosci. 2008 Oct 22;28(43):10875-84
18945895
Development. 2005 Jun;132(12):2917-27
15930120
Trends Neurosci. 2007 Jun;30(6):268-75
17467065
J Biol Chem. 2010 Jun 11;285(24):18939-47
20404321
Dev Cell. 2008 Nov;15(5):773-80
19000841
Trends Neurosci. 2007 Apr;30(4):142-9
17324475
J Neurosci. 2008 Aug 20;28(34):8644-54
18716223
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9434-9
17517621
Development. 2010 Jul;137(13):2215-25
20530549
J Cell Biol. 2006 Jul 3;174(1):127-39
16818724
Nat Neurosci. 2003 Nov;6(11):1169-77
14528308
Neuron. 2002 Sep 12;35(6):1043-56
12354395
Cell. 2002 Nov 1;111(3):319-30
12419243
Cell. 2009 Oct 16;139(2):393-404
19837038
Neuron. 2010 Jul 15;67(1):33-48
20624590
J Comp Neurol. 1983 Nov 10;220(4):365-77
6643733
J Cell Sci. 1998 May;111 ( Pt 10):1351-61
9570753
Cell. 2006 May 5;125(3):432-3
16678089
Nat Neurosci. 2010 Aug;13(8):935-43
20601947
J Biol Chem. 2008 Feb 29;283(9):5918-27
18096705
Neuron. 2006 Jun 15;50(6):897-909
16772171
Development. 2009 Oct;136(19):3205-14
19736321
Biochem Soc Trans. 2005 Dec;33(Pt 6):1295-8
16246102