Bilateral hippocampal atrophy in temporal lobe epilepsy: effect of depressive symptoms and febrile seizures.
OBJECTIVE
Neuroimaging studies suggest a history of febrile seizures, and depression, are associated with hippocampal volume reductions in patients with temporal lobe epilepsy (TLE).


METHODS
We used radial atrophy mapping (RAM), a three-dimensional (3D) surface modeling tool, to measure hippocampal atrophy in 40 patients with unilateral TLE, with or without a history of febrile seizures and symptoms of depression. Multiple linear regression was used to single out the effects of covariates on local atrophy.


RESULTS
Subjects with a history of febrile seizures (n =15) had atrophy in regions corresponding to the CA1 and CA3 subfields of the hippocampus contralateral to seizure focus (CHC) compared to those without a history of febrile seizures (n = 25). Subjects with Beck Depression Inventory II (BDI-II) score ≥ 14 (n = 11) had atrophy in the superoanterior portion of the CHC compared to subjects with BDI-II <14 (n = 29).


CONCLUSIONS
Contralateral hippocampal atrophy in TLE may be related to febrile seizures or depression.
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Andrey
A
Finegersh
Christina
C
Avedissian
Sadat
S
Shamim
Irene
I
Dustin
Paul M
PM
Thompson
William H
WH
Theodore
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D003866:Depressive Disorder / Q000150:complications / Q000473:pathology*; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D003294:Seizures, Febrile / Q000150:complications / Q000473:pathology*; D055815:Young Adult
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