Successful treatment of life-threatening pentoxifylline intoxication by high-flux hemodialysis.
High-flux hemodialysis is the method of choice for the treatment of many life threatening intoxications. Reports on intoxication with pentoxifylline are rare, and although pharmacokinetic properties of the drug suggest a potential role for hemodialysis, there are no published reports on extracorporeal treatment attempts. We report the first case of successful treatment of potentially life-threatening pentoxifylline intoxication by high-flux hemodialysis. Based on this single case, dialysis should be considered, especially in anuric patients with pentoxifylline intoxication.
Department of Nephrology and Hypertension, Center for Internal Medicine, Medical School Hannover, Hannover, Germany.
G
G
Eden
M
M
Busch
W N
WN
Kühn-Velten
A
A
Schneider
J T
JT
Kielstein
D000138:Acidosis / Q000139:chemically induced / Q000628:therapy*; D000328:Adult; D001002:Anuria / Q000139:chemically induced / Q000628:therapy*; D005260:Female; D006801:Humans; D009846:Oliguria / Q000139:chemically induced / Q000628:therapy*; D010431:Pentoxifylline / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D006435:Renal Dialysis / Q000379:methods*; D013406:Suicide, Attempted; D016896:Treatment Outcome
D010431:Pentoxifylline