Negative-pressure pulmonary edema presented with concomitant spontaneous pneumomediastinum: Moore meets Macklin.
Negative-pressure pulmonary edema is an unusual complication mainly associated with general anesthesia. It is caused by excessive negative intrathoracic pressure following a deep inspiration against an acute airway obstruction. The resultant decreased intrathoracic pressure amplifies venous return to the right heart and increases pulmonary capillary wedge pressure that can be further amplified by massive sympathetic discharge due to hypoxia. The combination of increased venous return and pulmonary capillary wedge pressure favours the shift of fluid into the pulmonary interstitium with resultant pulmonary edema. Conversely, spontaneous pneumomediastinum (SP) results from alveolar rupture following an excessive positive intrathoracic pressure. The air leaks out of the alveoli and along the perivascular space toward the mediastinum. We experienced a case of negative pulmonary edema which presented in association with SP. Pneumomediastinum is probably caused by an excessive positive intrathoracic pressure for a subsequent expiration against a closed airway. In the present case, both complications resolved with conservative management.
Thoracic Surgery Unit, Second University of Naples, Naples, Italy.
Alfonso
A
Fiorelli
Sergio
S
Brongo
Francesco
F
D'Andrea
Mario
M
Santini
D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D006177:Gynecomastia / Q000601:surgery; D006801:Humans; D001239:Inhalation; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D008478:Mediastinal Emphysema / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011654:Pulmonary Edema / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure; D014057:Tomography, X-Ray Computed; D014690:Venous Pressure