Magnesium citrate with a single dose of sodium phosphate for colonoscopy bowel preparation.
OBJECTIVE
To evaluate the efficacy and acceptability of magnesium citrate and a single dose of oral sodium phosphate (45 mL) solution for morning colonoscopy bowel preparation.


METHODS
A total of 159 patients were randomly assigned to receive two split doses of 90 mg of sodium phosphate (Group I, n = 79) or magnesium citrate (250 mL, the day before the procedure) followed by 45 mL of sodium phosphate (the day of procedure, Group II, n = 80). The quality of bowel cleansing and the acceptability of each regimen were compared, including the satisfaction, taste, willing to repeat and adverse effects of each regimen.


RESULTS
The quality of bowel cleansing of Group II was as good as that of Group I (An Aronchick scale score of good or excellent: 70.9% vs 81.0%, respectively, P = 0.34; the Ottawa system score: 4.4 ± 2.6 vs 3.8 ± 3.0, respectively, P = 0.76). There was no statistically significant difference between both groups with regard to acceptability, including the satisfaction, taste and willingness to repeat the regimen. A significantly greater number of older patients (over 65 years old) in Group II graded the overall satisfaction as satisfactory (48.1% vs 78.1%, respectively; Group I vs Group II, P = 0.01). There were no significant adverse reactions.


CONCLUSIONS
Magnesium citrate and a single dose of sodium phosphate was as effective and tolerable as the conventional sodium phosphate regimen and is a satisfactory option.
Department of Gastroenterology, Daehang Hospital, Seoul 137-820, South Korea. yschoi71@dreamwiz.com
Yong Sung
YS
Choi
Jung Pil
JP
Suh
Jong Kyu
JK
Kim
In Taek
IT
Lee
Eui Gon
EG
Youk
Doo Seok
DS
Lee
Do Sun
DS
Kim
Doo Han
DH
Lee
D000284:Administration, Oral; D000368:Aged; D002400:Cathartics / Q000494:pharmacology*; D019343:Citric Acid / Q000494:pharmacology*; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007422:Intestines / Q000473:pathology; D054368:Laxatives / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology*; D011446:Prospective Studies; D016896:Treatment Outcome
D002400:Cathartics; D054368:Laxatives; D009942:Organometallic Compounds; D010710:Phosphates; D019343:Citric Acid; C110422:magnesium citrate; C018279:sodium phosphate
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