Long-term effects of neonatal methamphetamine exposure on cognitive function in adolescent mice.
Exposure to methamphetamine during brain development impairs cognition in children and adult rodents. In mice, these impairments are greater in females than males. Adult female, but not male, mice show impairments in novel location recognition following methamphetamine exposure during brain development. In contrast to adulthood, little is known about the potential effects of methamphetamine exposure on cognition in adolescent mice. As adolescence is an important time of development and is relatively understudied, the aim of the current study was to examine potential long-term effects of neonatal methamphetamine exposure on behavior and cognition during adolescence. Male and female mice were exposed to methamphetamine (5 mg/kg) or saline once a day from postnatal days 11 to 20, the period of rodent hippocampal development. Behavioral and cognitive function was assessed during adolescence beginning on postnatal day 30. During the injection period, methamphetamine-exposed mice gained less weight on average compared to saline-exposed mice. In both male and female mice, methamphetamine exposure significantly impaired novel object recognition and there was a trend toward impaired novel location recognition. Anxiety-like behavior, sensorimotor gating, and contextual and cued fear conditioning were not affected by methamphetamine exposure. Thus, neonatal methamphetamine exposure affects cognition in adolescence and unlike in adulthood equally affects male and female mice.
Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. siegelj@ohsu.edu
Jessica A
JA
Siegel
Byung S
BS
Park
Jacob
J
Raber
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D003463:Cues; D005106:Exploratory Behavior / Q000187:drug effects; D005239:Fear / Q000523:psychology; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000254:growth & development*; D007274:Injections, Intraperitoneal; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D021641:Recognition, Psychology / Q000187:drug effects; D013216:Reflex, Startle / Q000187:drug effects; D055139:Sensory Gating / Q000187:drug effects; D012727:Sex Characteristics; D015430:Weight Gain / Q000187:drug effects
D000697:Central Nervous System Stimulants; D008694:Methamphetamine
Psychiatry Res. 2004 Dec 15;132(2):95-106
15598544
Neurotoxicology. 2007 Sep;28(5):931-7
17368774
J Neurochem. 2008 Nov;107(4):976-86
18786166
Behav Pharmacol. 2010 Oct;21(7):602-14
20729719
Synapse. 2003 Jun 1;48(3):131-7
12645038
Int J Dev Neurosci. 2009 May;27(3):289-98
19136054
J Neurosci Methods. 2008 Mar 15;168(2):422-30
18096240
Hippocampus. 2010 Jan;20(1):19-23
19489001
Neurotoxicol Teratol. 2011 Jan-Feb;33(1):166-75
20615464
Endocr Rev. 2004 Dec;25(6):947-70
15583024
Neuropsychopharmacology. 2007 Mar;32(3):665-72
16710318
Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):163-75
14741761
Neuroimage. 2009 Nov 1;48(2):391-7
19576287
Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
10817843
Neurotoxicol Teratol. 1992 May-Jun;14(3):221-8
1635542
Neuroscience. 2006;137(2):413-23
16330151
Brain Res Bull. 2002 Jan 1;57(1):57-71
11827738
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jan;30(1):82-8
16046043
Behav Neurosci. 1992 Apr;106(2):274-85
1590953
Psychoneuroendocrinology. 2007 Jul;32(6):734-45
17606327
Psychopharmacology (Berl). 2010 Oct;212(2):243-9
20640405
J Toxicol Environ Health A. 2007 Jan;70(1):7-18
17162495
Learn Mem. 2009 Jul 24;16(8):494-503
19633139
Dev Psychobiol. 2010 Jan;52(1):71-7
19937742
Neurotoxicol Teratol. 2010 May-Jun;32(3):356-61
20153424
Neurotoxicol Teratol. 2008 Jan-Feb;30(1):20-8
18031987
J Neurosci. 2000 Jun 15;20(12):4732-9
10844042
Neurosci Lett. 1986 May 23;66(3):281-6
2425289
Endocrinology. 2008 Oct;149(10):4892-900
18566122
J Neurosci. 2006 Jun 14;26(24):6603-9
16775148
Behav Neurosci. 1992 Jun;106(3):447-56
1616611
Obstet Gynecol. 2009 Jun;113(6):1285-1291
19461424
J Neurosci. 2002 Jun 15;22(12):5204-9
12077215
Horm Behav. 2004 Jun;46(1):30-8
15215039
Cell Mol Neurobiol. 1997 Dec;17(6):699-715
9442354
Behav Brain Res. 2002 Jun 15;133(1):57-68
12048174
Pharmacol Biochem Behav. 1996 Aug;54(4):687-91
8853190
Behav Brain Res. 2010 Mar 17;208(1):63-71
19900489
Int J Dev Neurosci. 2010 Jun;28(4):331-42
20184951
Prague Med Rep. 2008;109(1):62-70
19097391
J Dev Behav Pediatr. 2003 Feb;24(1):17-23
12584481
Pediatrics. 2006 Sep;118(3):1149-56
16951010
Eur J Neurosci. 2004 Jun;19(12):3165-70
15217372
Behav Pharmacol. 2007 Sep;18(5-6):549-62
17762523
Synapse. 1993 Mar;13(3):241-50
8497809
Brain Res Dev Brain Res. 2005 Jun 30;157(2):217-9
15936828
Brain Res. 2002 Dec 27;958(2):312-21
12470867
Psychopharmacology (Berl). 2003 Jul;168(3):329-38
12684734
J Neurochem. 2008 Mar;104(6):1674-85
17996031
Synapse. 2003 Jun 1;48(3):138-48
12645039
J Addict Dis. 2010 Apr;29(2):259-76
20407981
Brain Res. 2001 Nov 16;919(1):160-5
11689174
Neuroinformatics. 2007 Spring;5(1):79-94
17426354