Serum levels of adipokines resistin and leptin in patients with colon cancer.
Adipose tissue displays characteristics of an endocrine organ releasing a number of adipocyte-specific factors known as adipocytokines. It has been recently suggested that adipocytokines may play a role in pathogenesis and progression of certain cancers, in particular in colorectal cancer. The aim of this study was to investigate the association between several blood adipocytokine levels and clinicopathological characteristics of colon cancer patients undergoing surgery. The study group comprised of 29 patients who underwent surgical resection for colon cancer at Emergency University Hospital Bucharest and 27 healthy volunteers. The serum levels of adipocytokines were measured using multianalyte xMap profiling technology (Luminex). Resistin levels were significantly higher in colon cancer patients while leptin serum levels were significantly lower as compared to controls. Leptin levels decreased gradually with tumor stage and aggressiveness. Taken together, these results of this study suggest that adipokines, in particular resistin and leptin may be involved in development and progression of colon cancer.
Infection and Immunity Laboratory, Cantacuzino National Institute for Research and Development in Microbiology and Immunology, Bucharest, Romania. immuno@cantacuzino.ro
Aurora
A
Sălăgeanu
Catalin
C
Tucureanu
Lucian
L
Lerescu
Iuliana
I
Caraş
Ramona
R
Pitica
Gabriel
G
Gangurà
Radu
R
Costea
Stefan
S
Neagu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000097:blood* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D052243:Resistin / Q000097:blood*
D020738:Leptin; C499624:RETN protein, human; D052243:Resistin
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