Simultaneous in vivo dynamic contrast-enhanced magnetic resonance and scintigraphic imaging.
In this study, we investigated the in vivo application of an integrated small-animal magnetic resonance (MR) and gamma-ray imaging system that consists of a semiconductor-based radiation detector, a parallel-hole collimator, and a specialized radiofrequency coil. Gadodiamide and (99m)Tc sestimibi agents were injected simultaneously into a mouse, and simultaneous dynamic contrast-enhanced MR and scintigraphic images of the kidneys were acquired. The time curves of both the MR signal intensity and radioactivity indicate a rapid uptake of the agents followed by a more gradual excretion, consistent with the previously reported literature. Our results demonstrate the feasibility of measuring multiple biological processes at the same time using both MR contrast agents and radiotracers.
Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA. markjham@uci.edu
Mark J
MJ
Hamamura
Werner W
WW
Roeck
Seunghoon
S
Ha
James
J
Hugg
Douglas J
DJ
Wagenaar
Dirk
D
Meier
Bradley E
BE
Patt
Orhan
O
Nalcioglu
D000818:Animals; D003287:Contrast Media; D005260:Female; D007668:Kidney / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D011877:Radionuclide Imaging / Q000379:methods*; D017256:Technetium Tc 99m Sestamibi
D003287:Contrast Media; D017256:Technetium Tc 99m Sestamibi