Synthesis of MUC1 Neoglycopeptides using efficient microwave-enhanced chaotrope-assisted click chemistry.
The first synthesis of click neoglycopeptide analogues of the biologically relevant MUC1 sequence is reported. In the process, microwave-enhanced chaotrope-assisted click reaction conditions that may be used on a routine basis for the synthesis of click peptide conjugates have been developed. The convergent route for the synthesis of neoglycopeptides using these reaction conditions enables the facile, rapid, and highly efficient preparation of focused neoglycopeptide libraries of defined chemical structure for biological evaluation.
The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Dong Jun
DJ
Lee
Paul W R
PW
Harris
Margaret A
MA
Brimble
D001386:Azides / Q000737:chemistry; D057930:Click Chemistry; D006020:Glycopeptides / Q000138:chemical synthesis*; D008872:Microwaves; D015394:Molecular Structure; D018396:Mucin-1 / Q000737:chemistry*; D010446:Peptide Fragments / Q000138:chemical synthesis*
D001386:Azides; D006020:Glycopeptides; D018396:Mucin-1; D010446:Peptide Fragments