Helicobacter pylori Seropositivity Is Associated with Gastric Cancer Regardless of Tumor Subtype in Korea.
OBJECTIVE
To evaluate the association between Helicobacter pylori (H. pylori) infection and gastric cancer (GC) according to tumor subtype in Korea.


METHODS
H. pylori status was determined serologically using the enzyme-linked immunosorbent assay. In total, 2,819 patients with GC and 562 healthy controls were studied. A logistic regression method was used after adjusting for possible confounders.


RESULTS
The prevalence of H. pylori infection was significantly higher in the GC patients (84.7%) than in the controls (66.7%) (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.46-3.97). The adjusted OR was significantly higher in H. pylori-infected patients aged <60 years (OR, 4.69; 95% CI, 3.44-6.38) than in those aged ≥60 years (OR, 1.48; 95% CI, 0.88-2.46; p<0.001). Subgroup analyses revealed no differences in seroprevalence between early gastric cancer (84.8%; OR, 3.01; 95% CI, 2.27-4.01) and advanced gastric cancer (84.6%; OR, 2.94; 95% CI, 2.24-3.85), cardia cancer (83.8%; OR, 2.98; 95% CI, 2.16-4.02) and noncardia cancer (84.8%; OR, 3.17; 95% CI, 2.48-4.04), and differentiated carcinoma (82.7%; OR, 2.99; 95% CI, 2.21-4.04) and undifferentiated carcinoma (86.8%; OR, 3.05; 95% CI, 2.32-4.00).


CONCLUSIONS
The seroprevalence of H. pylori was higher in GC patients than in healthy controls, especially in younger patients. H. pylori infection is associated with GC, regardless of the tumor location, stage, or differentiation.
Research Institute and Hospital, Goyang, Korea.
Soo-Jeong
SJ
Cho
Il Ju
IJ
Choi
Chan Gyoo
CG
Kim
Jong Yeul
JY
Lee
Myeong-Cherl
MC
Kook
Moon-Woo
MW
Seong
Sook Ryun
SR
Park
Jong Seok
JS
Lee
Young-Woo
YW
Kim
Keun Won
KW
Ryu
Jun Ho
JH
Lee
Byung-Ho
BH
Nam
Young-Iee
YI
Park
Gut. 2008 Mar;57(3):298-305
17965056
Gut. 1992 Apr;33(4):429-31
1582581
Clin Diagn Lab Immunol. 2002 Nov;9(6):1313-7
12414766
Scand J Gastroenterol. 1996 Nov;31(11):1041-6
8938894
Acta Pathol Microbiol Scand. 1965;64:31-49
14320675
J Natl Cancer Inst. 2001 Feb 7;93(3):226-33
11158192
Int J Cancer. 1996 Jul 3;67(1):1-5
8690507
Gastroenterology. 1995 Sep;109(3):885-8
7657118
CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
15761078
J Natl Cancer Inst. 2004 Mar 3;96(5):388-96
14996860
N Engl J Med. 2001 Sep 13;345(11):784-9
11556297
J Natl Cancer Inst. 2006 Oct 18;98(20):1445-52
17047193
Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:85-9
15298611
Int J Cancer. 2003 Oct 10;106(6):953-60
12918076
J Natl Cancer Inst. 2000 Oct 4;92(19):1607-12
11018097
World J Gastroenterol. 2006 Mar 7;12(9):1346-51
16552799
Int J Cancer. 1983 Apr 15;31(4):421-6
6832853
Hepatogastroenterology. 1999 Jul-Aug;46(28):2690-3
10522066
Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1341-7
16835334
Arch Surg. 2008 Nov;143(11):1062-7; discussion 1067
19015464
Ann Surg Oncol. 2000 Aug;7(7):515-9
10947020
Aust N Z J Surg. 1999 Jun;69(6):443-6
10392889
J Surg Oncol. 1999 Aug;71(4):214-9
10440758
J Gastroenterol. 2001 Dec;36(12):816-22
11777209
Int J Cancer. 2002 Oct 10;101(5):469-74
12216076
Cancer Res. 1998 Feb 15;58(4):588-90
9485003
Gut. 2001 Sep;49(3):347-53
11511555
Int J Cancer. 2004 Mar;109(1):138-43
14735480
Gastroenterology. 1996 Nov;111(5):1206-11
8898634
Nat Immunol. 2004 Feb;5(2):133-9
14749784
Surg Today. 1992;22(5):421-5
1421863
Cancer Res Treat. 2005 Dec;37(6):325-31
19956367
J Surg Oncol. 1994 Jan;55(1):3-6
8289449
J Gastroenterol Hepatol. 1997 Feb;12(2):100-3
9083909
Cancer Res. 1992 Dec 15;52(24):6735-40
1458460
Gastroenterology. 1991 Jul;101(1):167-74
2044906
J Surg Oncol. 1995 Mar;58(3):191-5
7898116
Gastroenterology. 1998 Jun;114(6):1169-79
9609753
J Gastroenterol Hepatol. 2001 Sep;16(9):969-75
11595059
J Surg Oncol. 1996 Sep;63(1):36-40
8841464
Cancer. 1998 Nov 15;83(10):2049-53
9827707
J Epidemiol. 2003 May;13(3):162-8
12749604
Am J Gastroenterol. 2007 Aug;102(8):1789-98
17521398
Gut. 1994 Oct;35(10):1372-4
7959189
IARC Monogr Eval Carcinog Risks Hum. 1994;61:1-241
7715068
N Engl J Med. 1991 Oct 17;325(16):1127-31
1891020
Int J Gastrointest Cancer. 2005;35(1):43-52
15722573
Gut. 2005 Mar;54 Suppl 1:i1-5
15711002
Jpn J Surg. 1981 Mar;11(2):127-39
7300058
Am J Gastroenterol. 1998 Oct;93(10):1800-2
9772034
J Natl Cancer Inst. 1991 May 1;83(9):640-3
2023282
Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2203-7
15598781
Eur J Gastroenterol Hepatol. 2002 Feb;14(2):115-22
11981334
Cancer. 1993 Sep 15;72(6):1841-5
8364862
Br J Cancer. 2005 Apr 11;92(7):1273-5
15756269
Gastric Cancer. 1998 Dec;1(1):10-24
11957040
World J Gastroenterol. 2005 Jan 7;11(1):22-6
15609390
Helicobacter. 2007 Aug;12(4):333-40
17669107
Gut. 1998 Jan;42(1):20-3
9505880