Chemopreventive effects of dietary canola oil on colon cancer development.
Fatty acid composition of dietary fat plays a vital role in colon tumor development in animal models. Fats containing ω-6 fatty acids (e.g., corn oil) enhanced and ω-3 fatty acids (e.g., flaxseed oil) reduced chemically induced colon tumor development in rats. The objective of the present investigation was to study the effects of dietary canola oil, a source of ω-3 fatty acid on azoxymethane-induced colon cancer development in Fischer rats and compare with dietary corn oil. Dietary canola oil significantly (P<0.05) decreased colonic tumor incidence and tumor multiplicity as compared to dietary corn oil in rats. Fatty acid analysis showed that corn oil group had higher levels of ω-6 fatty acid levels, whereas the canola oil groups exhibited higher levels of ω-3 fatty acids from the colon and serum samples of rats. For the mechanistic study, COX-2 expression in the colon samples from the canola oil group was significantly lower (P<0.05) as compared to the corn oil group. Taken together, dietary canola oil may be chemopreventive for colon tumor development in Fischer rats as compared to possibly by increasing ω-3 fatty acid levels and decreasing COX-2 levels.
Department of Pharmaceutical Sciences, South Dakota State University, Brookings, South Dakota 57007, USA.
Ekta
E
Bhatia
Chaitanya
C
Doddivenaka
Xiaoying
X
Zhang
Ajay
A
Bommareddy
Padmanabhan
P
Krishnan
Duane P
DP
Matthees
Chandradhar
C
Dwivedi
D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D018890:Chemoprevention; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology / Q000517:prevention & control*; D003314:Corn Oil / Q000008:administration & dosage; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage*; D019587:Dietary Supplements; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage; D008043:Linseed Oil / Q000008:administration & dosage; D008297:Male; D000074262:Rapeseed Oil; D051381:Rats; D011916:Rats, Inbred F344
D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D000074262:Rapeseed Oil; D008043:Linseed Oil; D003314:Corn Oil; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat; D001397:Azoxymethane