Bioactive compounds from marine bacteria and fungi.
Marine bacteria and fungi are of considerable importance as new promising sources of a huge number of biologically active products. Some of these marine species live in a stressful habitat, under cold, lightless and high pressure conditions. Surprisingly, a large number of species with high diversity survive under such conditions and produce fascinating and structurally complex natural products. Up till now, only a small number of microorganisms have been investigated for bioactive metabolites, yet a huge number of active substances with some of them featuring unique structural skeletons have been isolated. This review covers new biologically active natural products published recently (2007-09) and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.
Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine Universitaet Duesseldorf, Germany.
Abdessamad
A
Debbab
Amal H
AH
Aly
Wen H
WH
Lin
Peter
P
Proksch
D001419:Bacteria / Q000378:metabolism*; D001685:Biological Factors / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D012623:Seawater / Q000382:microbiology*
D001685:Biological Factors
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