Autophagy in cardiac plasticity and disease.
The heart is a highly plastic organ. In response to the physiological stress of normal life, as well as the pathological stress of disease, the myocardium manifests robust and rapid changes in mass. In the context of disease-associated stress, this myocardial remodeling response can culminate in ventricular thinning, mechanical dysfunction, and a clinical syndrome of heart failure. Recently, autophagy, a process of cellular cannibalization, has been implicated in many of these remodeling reactions. In some settings, the autophagic response is beneficial and pro-survival; in other contexts, it is maladaptive and promotes disease progression. Together, these observations raise the intriguing prospect of targeting maladaptive autophagy and advancing cell survival-promoting, adaptive autophagy to benefit patients with heart disease.
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, NB11.200, 6000 Harry Hines Blvd, Dallas, TX 75390-8573, USA. joseph.hill@utsouthwestern.edu
Joseph A
JA
Hill
D001343:Autophagy; D006331:Heart Diseases / Q000473:pathology*; D006801:Humans; D009206:Myocardium / Q000473:pathology*; D020257:Ventricular Remodeling
Genes Dev. 2007 Nov 15;21(22):2861-73
18006683
J Mol Cell Cardiol. 2006 Jun;40(6):846-52
16697404
Nature. 2010 Jun 17;465(7300):942-6
20526321
Cell. 2007 Aug 10;130(3):427-39
17693254
Nat Cell Biol. 2007 Oct;9(10):1102-9
17909521
J Mol Cell Cardiol. 2000 Jan;32(1):161-75
10652200
J Biol Chem. 2005 Dec 2;280(48):40282-92
16192271
Circulation. 2006 Oct 24;114(17):1821-8
17043166
J Clin Invest. 2005 Aug;115(8):2108-18
16075055
Nat Med. 2007 May;13(5):619-24
17450150
Circ Res. 2008 Dec 5;103(12):1363-9
19059838
Curr Opin Cell Biol. 2002 Dec;14(6):727-33
12473346
EMBO J. 2008 Jan 23;27(2):433-46
18200046
J Cell Biol. 2000 Sep 18;150(6):1507-13
10995454
Jpn Circ J. 2001 Nov;65(11):965-8
11716248
N Engl J Med. 2004 Nov 11;351(20):2087-100
15537907
Curr Top Microbiol Immunol. 2004;279:73-84
14560952
N Engl J Med. 2000 Mar 16;342(11):770-80
10717012
J Mol Cell Cardiol. 1980 Nov;12(11):1175-89
7441766
Circ Res. 2007 Mar 30;100(6):914-22
17332429
Cell. 2008 Jan 11;132(1):27-42
18191218
N Engl J Med. 1990 May 31;322(22):1561-6
2139921
Circulation. 2003 Feb 25;107(7):984-91
12600911
J Biol Chem. 2008 Apr 18;283(16):10892-903
18281291
Circulation. 2004 Apr 6;109(13):1580-9
15066961
J Clin Invest. 2007 Oct;117(10):2825-33
17909626
JAMA. 2009 Mar 25;301(12):1253-9
19318653
Basic Res Cardiol. 2009 Mar;104(2):157-67
19242639
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10132-6
15220483
Hypertension. 2006 May;47(5):887-93
16567591
Circulation. 2005 Nov 29;112(22):3451-61
16316967
Circulation. 2008 Jun 17;117(24):3070-8
18541737
Dev Cell. 2004 Apr;6(4):463-77
15068787
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8
21367693
Annu Rev Pathol. 2008;3:427-55
18039129
Mol Biol Cell. 2004 May;15(5):2335-46
15004226
Science. 2009 Apr 3;324(5923):98-102
19342590
Nature. 2008 Feb 28;451(7182):1069-75
18305538
J Am Coll Cardiol. 2004 Jun 16;43(12):2191-9
15193679
Nature. 2000 Aug 24;406(6798):906-10
10972294
J Mol Cell Cardiol. 1987 Dec;19(12):1179-84
3443985
J Clin Invest. 2007 Jul;117(7):1782-93
17607355
Circ Res. 2001 Jul 6;89(1):84-91
11440982
Circ Res. 2005 Nov 11;97(10):1018-26
16210548
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13807-12
16174725
Am J Pathol. 1980 Feb;98(2):425-44
7355988
Cardiovasc Res. 2001 Aug 1;51(2):304-12
11470470
Cell Death Differ. 2007 Jan;14(1):146-57
16645637
J Cell Mol Med. 2009 Feb;13(2):373-87
18793351
Am J Pathol. 2009 May;174(5):1705-14
19342365
Am J Pathol. 1980 Feb;98(2):445-56
6986784
Trends Mol Med. 2007 Nov;13(11):482-91
18029229
Cell Death Differ. 2009 Jan;16(1):31-8
19008922
Sci Signal. 2009 Aug 18;2(84):pe51
19690328
Arch Biochem Biophys. 2007 Jun 15;462(2):245-53
17475204
N Engl J Med. 2008 Mar 27;358(13):1370-80
18367740
Nat Genet. 1998 Sep;20(1):92-5
9731540
Nature. 2000 Aug 24;406(6798):902-6
10972293
Autophagy. 2007 Nov-Dec;3(6):632-4
17786025
Physiol Rev. 1992 Apr;72(2):369-417
1372998
J Clin Invest. 2005 Oct;115(10):2679-88
16200202
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9745-50
18621691
J Biol Chem. 2006 Oct 6;281(40):29776-87
16882669
Circ Res. 2003 Apr 18;92(7):715-24
12649263
Dev Cell. 2009 Jul;17(1):98-109
19619495
Semin Cell Dev Biol. 2010 Sep;21(7):664-70
20359542
Circulation. 2000 Jun 20;101(24):2863-9
10859294
Circulation. 2001 May 15;103(19):2402-7
11352891
Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7
17712358