[Supraoptic nucleus of hypothalamus in subjects with chronic heart failure].
Postmortem paraffin hypothalamic blocks from male subjects with chronic heart failure (CHF) were used for morphometric and immunohistochemical studies of the supraoptical nucleus (SON). Morphometric analysis revealed a significant enlargement of pericarya and nuclei in SON of CHF subjects compared with controls. In addition, eccentrically positioned nucleoli were more frequently found in SON of the subjects with CHF. Moreover, a significant rise in relative entropy of all studied parameters of SON was documented in CHF subjects. The immunohistochemical study revealed a substantial increase of vasopressin immunoreactivity in SON neurons of the CHF subjects in comparison with control ones. Taken together, these results suggest considerable enhancement of synthetic activity of SON neurons in patients with CHF consistent with clinical observations that demonstrate significant elevation of blood vasopressin levels in patients with chronic cardiac insufficiency.
E V
EV
Sivukhina
Iu E
IuE
Morozov
G F
GF
Jirikowski
V V
VV
Grinevich
D000368:Aged; D002908:Chronic Disease; D006333:Heart Failure / Q000097:blood / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055099:Neuroendocrine Cells / Q000378:metabolism / Q000473:pathology*; D009489:Neurosecretion; D013495:Supraoptic Nucleus / Q000473:pathology*; D014667:Vasopressins / Q000097:blood / Q000378:metabolism
D014667:Vasopressins