Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice.
The efficacy of a crude hydro-alcoholic extract of Cassia fistula (golden shower tree) fruit to protect the kidney against bromobenzene-induced toxicity was studied. Negative control mice received normal saline; positive control mice were given 460 mg/kg of bromobenzene; Cassia fistula treated mice received 200, 400, 600 and 800 mg/kg of Cassia fistula fruit extract followed by 460 mg/kg bromobenzene (daily by oral gavage for 10 days). On the 11th day, the mice were sacrificed, blood samples were obtained to assess blood urea nitrogen (BUN) and creatinine levels, and kidneys were removed for histological examination. We found that bromobenzene induced significant nephrotoxicity reflected by an increase in levels of BUN and creatinine that was dose dependently prevented by the Cassia fistula fruit extract. The nephroprotective effect of the Cassia fistula fruit extract was confirmed by the histological examination of the kidneys. To the best of our knowledge, this is the first study to demonstrate the protective effect of Cassia fistula in nephrotoxicity.
School of Pharmacy, Toxicology Center, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran.
Heibatullah
H
Kalantari
Mohammadtaha
M
Jalali
Amir
A
Jalali
Abobakr
A
Salimi
Foad
F
Alhalvachi
Balazs
B
Varga
Bela
B
Juhasz
Anita
A
Jakab
Adam
A
Kemeny-Beke
Rudolf
R
Gesztelyi
Arpad
A
Tosaki
Judit
J
Zsuga
D000818:Animals; D001806:Blood Urea Nitrogen; D001969:Bromobenzenes / Q000633:toxicity*; D002366:Cassia / Q000737:chemistry*; D003404:Creatinine / Q000097:blood; D005638:Fruit / Q000737:chemistry; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*
D001969:Bromobenzenes; D010936:Plant Extracts; D020011:Protective Agents; D003404:Creatinine; C032036:bromobenzene