Evaluation of S-adenosyl l-methionine in a double-blinded, randomized, placebo-controlled, clinical trial for treatment of presumptive osteoarthritis in the dog.
OBJECTIVE
To evaluate the efficacy of S-adenosyl l-methionine (SAMe) in the treatment of clinically inferred canine osteoarthritis (OA).


METHODS
Six weeks, double-blinded, placebo-controlled, clinical trial.


METHODS
Dogs (n=33) with clinical signs, history, and orthopedic exams consistent with OA.


METHODS
Dogs were block randomized by body condition score (<6/9, or ≥6/9) into either the placebo or SAMe group. Outcome was assessed using pressure platform gait analysis, examination score, goniometry, and the Canine Brief Pain Inventory (CBPI) at the time of study entrance and at 3 and 6 weeks after entry. Groups were compared using parametric and nonparametric paired tests as appropriate, and numbers needed to treat (NNT) were calculated for the CBPI and peak vertical force (PVF).


RESULTS
Both groups (n=15 placebo, n=18 SAMe) had a reduction in mean PVF (P=.02) and vertical impulse (VI; P=.06) from the 1st to 3rd visit. There was no significant difference between the placebo group and SAMe group for PVF, VI, or either part of the CBPI (Severity or Impact). The NNT at 6 weeks for the Severity score was 3, Impact score was 25, and PVF was 45.


CONCLUSIONS
These data do not support the use of SAMe as an effective stand alone treatment for reducing clinical signs of OA, as measured by PVF, VI, goniometry, CBPI (both Severity and Impact), and examination score within 6 weeks of treatment.
College of Veterinary Medicine, University of Illinois, Urbana-Champaign, IL, USA. darrenimhoff@mac.com
Darren J
DJ
Imhoff
Wanda J
WJ
Gordon-Evans
Richard B
RB
Evans
Ann L
AL
Johnson
Dominique J
DJ
Griffon
Kelly S
KS
Swanson
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004311:Double-Blind Method; D005684:Gait; D010003:Osteoarthritis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D012436:S-Adenosylmethionine / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D012436:S-Adenosylmethionine