[Immunohistochemic staining for CK5/6 and P63 significance in prostate premalignant lesions and adenocarcinoma].
The morphologic information from usual hematoxiline-eosine staining are sometimes insufficient in certifying or excluding the adenocarcinoma of the prostate, cases who must be study by immunohistochemistry.


OBJECTIVE
The investigation of staining for CK5/6 and P63 in cases diagnosed with prostate adenocarcinoma associated with high grade prostatic intraepithelial neoplasia.


METHODS
The study was realized on 56 cases analyzed in Pathology Laboratory of Focşani Emergency Hospital.


RESULTS
We registered a positive correct diagnosis for atypical adenomatous hyperplasia in 86% of cases and for prostate adenocarcinoma grade 1 in 14% of cases.


CONCLUSIONS
CK5/6 and P63 are useful markers for elucidating a positive false diagnosis for prostate adenocarcinoma grade 1.
Doctorand al Universităţii de Medicină şi Farmacie Gr.T. Popa Iaşi.
Ludmila Violeta
LV
Marin
D
D
Ferariu
Maria-Sultana
MS
Mihailovici
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D053555:Keratin-5 / Q000032:analysis*; D053553:Keratin-6 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000737:chemistry / Q000473:pathology*; D011237:Predictive Value of Tests; D019048:Prostatic Intraepithelial Neoplasia / Q000737:chemistry / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015534:Trans-Activators / Q000032:analysis*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000032:analysis*
D014408:Biomarkers, Tumor; D053555:Keratin-5; D053553:Keratin-6; C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins