GMP-140, a receptor that mediates interactions of leukocytes with activated platelets and endothelium.
GMP-140, a membrane glycoprotein located in secretory granules of platelets and endothelium, is rapidly redistributed to the cell surface following cellular activation. GMP-140 promotes rapid adhesion of neutrophils and monocytes to activated endothelium at sites of tissue injury as well as platelet-leukocyte interactions in areas of inflammation and hemorrhage. Like other leukocyte adhesion molecules, GMP-140 may also be involved in inflammatory disorders such as reperfusion injury. Further study of the structure and function of GMP-140 and related receptors may lead to development of new drugs that block leukocyte adhesion in human disease.
Department of Medicine, St. Francis Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
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