Retransplantation for donor-derived neuroendocrine tumor.
Although tumor transmission through liver transplantation (LT) is a rare occurrence, the consequences can be devastating, even when a very aggressive management approach is adopted. We report the case of a donor-derived small cell neuroendocrine tumor (NET) in a patient who underwent LT for cholangiocarcinoma. Despite locoregional therapy, chemotherapy and ultimately retransplantation, the patient died from metastases. The high grade nature of the NET was the most important determinant of prognosis in this case. Our experience suggests that retransplantation for donor-derived NET should only be considered when tumor biology is favorable.
Department of Transplant, Mayo Clinic, Jacksonville, FL 32224, USA.
Rehana
R
Begum
Denise
D
Harnois
Raj
R
Satyanarayana
Murli
M
Krishna
Kevin C
KC
Halling
George P
GP
Kim
Justin H
JH
Nguyen
Andrew P
AP
Keaveny
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001650:Bile Duct Neoplasms / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000209:etiology* / Q000235:genetics / Q000556:secondary / Q000628:therapy; D018281:Cholangiocarcinoma / Q000601:surgery*; D017809:Fatal Outcome; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008113:Liver Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D018358:Neuroendocrine Tumors / Q000209:etiology* / Q000235:genetics / Q000556:secondary / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000556:secondary; D012086:Reoperation; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome