Predictors of the risk of cognitive deficiency in very preterm infants: the EPIPAGE prospective cohort.
OBJECTIVE
To assess cerebral lesions and other medical as well as social characteristics as predictors of risk of mild and severe cognitive deficiencies in very preterm infants.


METHODS
As part of the EPIPAGE population-based prospective cohort study, perinatal data and cognitive outcome at 5 years of age were recorded for 1503 infants born before 33 weeks of gestation in nine regions of France in 1997. Mild cognitive deficiency was defined as a Mental Processing Composite score on the Kaufman Assessment Battery for Children test of between 70 and 84, and severe cognitive deficiency as a score of <70.


RESULTS
After controlling for cerebral lesions and other medical as well as social factors, low parental socio-economic status and lack of breastfeeding were significant predictors of mild and severe cognitive deficiencies, whereas presence of cerebral lesions, being small for gestational age and having a large number of siblings were predictors of severe cognitive deficiency.


CONCLUSIONS
Predictors of poor cognitive outcome in very preterm infants are low social status, lack of breastfeeding, presence of cerebral lesions on ultrasound scan, being born small for gestational age and having a high number of siblings. Social factors predicted both mild and severe cognitive deficiencies, whereas medical factors predicted mostly severe cognitive deficiencies.
INSERM, UMR S953, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Hôpital Tenon, F-75020, Paris, France. ghbeaino@chusa.jussieu.fr
Ghada
G
Beaino
Babak
B
Khoshnood
Monique
M
Kaminski
Stéphane
S
Marret
Véronique
V
Pierrat
Rachel
R
Vieux
Gérard
G
Thiriez
Jacqueline
J
Matis
Jean-Charles
JC
Picaud
Jean-Christophe
JC
Rozé
Corine
C
Alberge
Béatrice
B
Larroque
Gérard
G
Bréart
Pierre-Yves
PY
Ancel
D002675:Child, Preschool; D003072:Cognition Disorders / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012959:Socioeconomic Factors
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