Unusual computed tomography findings of radionecrosis after chemoradiation of stage IV hypopharyngeal cancer: a case report.
BACKGROUND
Radionecrosis (post-radiotherapy laryngeal submucosal inflammation and necrosis) is a complication of (chemo) radiotherapy for hypopharyngeal cancer that is difficult to differentiate from tumor recurrence.


METHODS
A 67-year-old Japanese man presented with a condition extremely difficult to diagnose differentially as radionecrosis or tumor recurrence after radiotherapy for hypopharyngeal cancer. Although tumor recurrence was suspected from clinical conditions and computed tomography findings, pathologic analysis revealed no evidence of tumor recurrence, and successful therapy with steroids and antibiotics reduced the mucosal edema.


CONCLUSIONS
Our findings emphasize the wide spectrum of radiographic presentation of radionecrosis after chemoradiation of stage IV hypopharyngeal cancer.
Department of Otorhinolaryngology, Ohtawara Red Cross Hospital, 2-7-3 Sumiyoshi-cho, Ohtawara City, Tochigi 324-8686, Japan. yuh_baba@hotmail.com.
Yuh
Y
Baba
Yasumasa
Y
Kato
Kaoru
K
Ogawa
J Laryngol Otol. 1993 Jun;107(6):565-8
8345309
Otolaryngol Head Neck Surg. 2006 Dec;135(6):838-43
17141070
J Laryngol Otol. 2005 Nov;119(11):922-5
16354349
AJNR Am J Neuroradiol. 1998 Apr;19(4):711-8
9576660
Int J Radiat Oncol Biol Phys. 2003 Dec 1;57(5):1231-8
14630256
Laryngoscope. 2009 Aug;119(8):1510-7
19504552
Ann Otol Rhinol Laryngol. 2000 Jun;109(6):554-62
10855566
Arch Otolaryngol. 1973 Aug;98(2):111-3
4723761
Laryngoscope. 1982 Feb;92(2):173-80
7162313
Laryngoscope. 2009 Jun;119(6):1130-4
19358250
Head Neck. 1989 May-Jun;11(3):252-6
2722502
Ann Otol Rhinol Laryngol. 1979 Jul-Aug;88(4 Pt 1):509-14
475247
Ann Otol Rhinol Laryngol. 1998 Apr;107(4):293-6
9557763