Kinetics of 1H→13C NMR cross-polarization in polymorphs and solvates of the antipsychotic drug olanzapine.
The (1)H→(13)C NMR cross-polarization (CP) was studied under magic-angle spinning at 7.5 kHz in various crystal forms of the antipsychotic drug olanzapine: two polymorphs (metastable I and stable II) and eight solvates containing organic solvent and water molecules. The CP kinetics followed the non-classical I-I(*)-S model, in which CP begins in a spin cluster of proximate abundant spins I(*) and rare spins S, then is controlled by spin diffusion of the abundant spins I from bulk to the I(*) spins of the spin cluster and finally is governed by spin-lattice relaxation of the abundant spins in the rotating frame. The corresponding CP kinetics parameters were determined and analyzed. It was demonstrated that the, λ and T(df) values (the CP time constant, the cluster composition parameter and the (1)H spin-diffusion constant, respectively) were very useful to discriminate the functional groups, especially in the 3D parameter space. In order to conveniently analyze the large amount (175) of the collected CP parameters, the number of the observed variables was reduced using the principal component (PC) analysis. The 2D plot of PC2 vs. PC1 showed adequate separation of the CH(3), CH(2), CH and C cases (C stands for carbons without adjacent hydrogens). It was demonstrated that those cases were located along the PC1 axis in the order of increasing (1)H-(13)C dipolar couplings: C<CH(3)<CH<CH(2). Our study showed the I-I(*)-S model at work and established ranges of its parameters for various functional groups.
Medical University of Warsaw, Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, ul. Banacha 1, 02-097 Warszawa, Poland. waclaw.kolodziejski@wum.edu.pl
Waclaw
W
Kolodziejski
Joanna
J
Herold
Marzena
M
Kuras
Irena
I
Wawrzycka-Gorczyca
Anna E
AE
Koziol
D014150:Antipsychotic Agents / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D000077152:Olanzapine; D012997:Solvents / Q000737:chemistry*
D014150:Antipsychotic Agents; D012997:Solvents; D001569:Benzodiazepines; D000077152:Olanzapine