Immunohistochemical and biomolecular identification of 5-HT₇ receptor in rat vestibular nuclei.
The association between migraine and balance disorder morbidities has been a topic of interest for many years, and serotonin (5-HT) receptor is known to be closely related with migraine and also to be associated with vestibular symptoms. However, the mechanism underlying the pathogenesis of migrainous vertigo and its association with 5-HT has not been elucidated. Of the many 5-HT receptors, 5-HT₇ receptor has recently attracted attention in the context of migraine treatment. The purpose of this study was to investigate the localization and expression of 5-HT₇ receptor in the rat vestibular nuclei by immunohistochemical staining and reverse transcriptase-polymerase chain reaction (RT-PCR). The present study might provide additional insight into the role of 5-HT₇ receptor in the pathogenesis of migraine-related vestibular symptoms.
Department of Otolaryngology, School of Medicine, Gyeongsang National University, Jinju, South Korea.
Roza
R
Khalmuratova
Young-Sool
YS
Hah
Seong-Ki
SK
Ahn
Sea-Yuong
SY
Jeon
Jin-Pyeong
JP
Kim
Carey D
CD
Balaban
D000818:Animals; D007150:Immunohistochemistry; D008297:Male; D008881:Migraine Disorders / Q000150:complications / Q000209:etiology*; D004856:Postural Balance; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014018:Tissue Distribution; D015837:Vestibular Diseases / Q000209:etiology; D014726:Vestibular Nuclei / Q000378:metabolism*
C522380:5-HT(7) receptor, rat; D012333:RNA, Messenger; D011985:Receptors, Serotonin