Thrombomodulin Biology and potential cardiovascular applications.
Thrombomodulin on endothelial surfaces is the major cofactor for the activation of the anticoagulant protein C by thrombin. Recent studies of the structure and regulation of thrombomodulin provide important clues as to its mechanism of action. These studies should enable the rational use of thrombomodulin as a therapeutic agent to inhibit coagulation either by infusion of thrombomodulin or its derivatives, or by pharmacologic alteration of cellular levels.
Department of Medicine, Durham VAMC USA; Duke University School of Medicine, Durham, NC 27705, USA.
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Dittman