G-protein-mediated regulation of phospholipase C Involvement of βγ subunits.
The protein components of the G-protein-linked cell surface receptor-regulated inositol lipid-signaling cascade have been identified recently. The G(q) family of G-protein α subunits is responsible for pertussis toxin-insensitive activation of a family of phospholipase C-β isoenzymes. However, it also has been shown that G-protein βγ subunits activate certain of these phospholipase C-β isoenzymes, and that this novel activity may account for activation of phospholipase C by G proteins that are not members of the G(q) family, including those that account for pertussis-toxin-sensitive inositol lipid signaling.
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
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J
Boyer
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A
Paterson
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TK
Harden