Preliminary study on changes in coagulation function and component transfusion time in patients with massive hemorrhage.
BACKGROUND
To investigate the changes in coagulation function and component transfusion time in patients with massive hemorrhage.


METHODS
Sixty-two patients with massive hemorrhage were enrolled in the study. Blood samples were collected from each patient when the blood loss reached 1000, 1500, 1700 and 2000 ml. The parameters FIB, PT, APTT, HGB, HCT, PLT and MAP were recorded for all patients.


RESULTS
Sixty-two, 30, 20 and 8 patients showed blood loss exceeding 1000, 1500, 1700 and 2000 ml, respectively. Blood samples were successfully collected from all patients when the volume of blood lost reached 1000, 1500, 1700 and 2000 ml. However, at this time point, FIB, MAP, HGB, HCT and PLT were significantly lower than the baseline/preoperative values. These indices decreased progressively with increasing blood loss. PT and APTT were significantly higher than at baseline and increased progressively with increased blood loss. FIB, HCT and HGB were below the normal reference range when blood loss was 1500 ml. During surgery, FIB, MAP, HCT, HGB and PLT decreased substantially, whereas APTT and PT increased when blood loss exceeded 1500 ml. PT and MAP were beyond the normal range when blood loss reached 2000 ml. There was a correlation between FIB, HCT and HGB with intraoperative blood loss; the correlation coefficient was greatest between and FIB and blood loss.


CONCLUSIONS
There were marked correlations between FIB, HCT and HGB with intraoperative blood loss, and the correlation was greatest with FIB.
Department of Anesthesiology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China.
Dongyou
D
Zheng
Hong
H
Pan
Xiaoguang
X
Cui
Fanyou
F
Meng
Guoqiang
G
Sun
Baoguo
B
Wang
D015415:Biomarkers; D001780:Blood Coagulation Tests; D016913:Blood Component Transfusion; D016063:Blood Loss, Surgical; D001932:Brain Neoplasms / Q000097:blood / Q000601:surgery; D016724:Empyema, Pleural / Q000097:blood / Q000601:surgery; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005910:Glioma / Q000097:blood / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D020896:Hypovolemia / Q000097:blood* / Q000209:etiology / Q000628:therapy; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010949:Plasma; D011446:Prospective Studies; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000628:therapy; D019616:Thoracic Surgical Procedures; D013997:Time Factors
D015415:Biomarkers; D005340:Fibrinogen