Neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma.
Although extraovarian mucinous cystadenocarcinomas resemble primary ovarian carcinomas, both histologically and clinically, their specific etiology is not clear. This is the first report to show neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma. The histologic spectrum and specific KRAS mutational analysis for this tumor were the same as for their ovarian counterparts. This supports a müllerian origin and the current approach to extrapolate the results from ovarian mucinous cystadenocarcinoma trials in prescribing treatment for patients with extraovarian mucinous cystadenocarcinomas.
GROW, School for Oncology and Developmental Biology, University of Maastricht/Maastricht University Medical Center, 6202AZ Maastricht, The Netherlands. arnoldjankruse@hotmail.com
Arnold-Jan
AJ
Kruse
Brigitte
B
Slangen
Gerard A
GA
Dunselman
Tina
T
Pirens
Frans C H
FC
Bakers
Jan P A
JP
Baak
Koen Van
KV
de Vijver
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D012809:Colon, Sigmoid; D003110:Colonic Neoplasms / Q000473:pathology*; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology*; D003560:Cysts / Q000473:pathology; D005260:Female; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology; D002577:Uterine Cervical Diseases / Q000473:pathology*