Persistence of a positive (1,3)-beta-D-glucan test after clearance of candidemia in hematopoietic stem cell transplant recipients.
In 6 hematopoietic stem cell transplant (HSCT) recipients with candidemia, the (1,3)-β-d-glucan (BG) test was positive a median of 2.5 days after a positive blood culture. Only in 1 patient did BG positivity precede positive blood cultures. BG concentrations decreased in patients with clinical response, but positive BG results persisted long after blood cultures became sterile (median, 48 days).
Division of Infectious Diseases, San Martino University Hospital, L.go R. Benzi 10, 16132 Genoa, Italy. m_mikulska@yahoo.com
M
M
Mikulska
E
E
Furfaro
V
V
Del Bono
F
F
Gualandi
M T
MT
Van Lint
F
F
Miletich
A
A
Bacigalupo
C
C
Viscoli
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002175:Candida / Q000302:isolation & purification; D058387:Candidemia / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011509:Proteoglycans; D013997:Time Factors; D047071:beta-Glucans / Q000097:blood*
D015415:Biomarkers; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K
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