Bio-functionalisation to enzymatically control the solution properties of a self-supporting polymeric material.
Molecular self-assembly permits the spontaneous aggregation of a variety of low molecular weight amino acid subunits into highly ordered aggregates. Functionalisation of water soluble poly(allylamine) with acetyl protected dialanine enables the formation of a biopolymer self-supporting material (SSM). The presence of an enzyme cleavable dipeptide linker renders the SSM responsive to disruption by a targeted proteolytic enzyme.
School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
Paul D
PD
Thornton
Andreas
A
Heise
D010196:Pancreatic Elastase / Q000378:metabolism*; D011073:Polyamines / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012996:Solutions; D013055:Spectrophotometry, Infrared
D011073:Polyamines; D011108:Polymers; D012996:Solutions; C063994:polyallylamine; D010196:Pancreatic Elastase