The risk of large for gestational age across increasing categories of pregnancy glycemia.
OBJECTIVE
We sought to estimate the risk of large for gestational age (LGA) across categories of glucose tolerance.


METHODS
In a cohort of 89,141 participants, women without gestational diabetes mellitus (GDM) were categorized by their screening and diagnostic test results; those with GDM were categorized as meeting the National Diabetes Data Group or only the American Diabetes Association (ADA) criteria. Multivariable logistic regression models estimated the risk of LGA; screening values 5.5-6.0 mmol/L comprised the referent.


RESULTS
In women without GDM, the odds ratio for LGA was 1.89 (95% confidence interval [CI], 1.45-2.45) for fasting, 1.57 (95% CI, 1.31-1.89) for 1-hour, 1.60 (95% CI, 1.33-1.93) for 2-hour, and 1.62 (95% CI, 1.23-2.14) for 3-hour values meeting the ADA time point-specific thresholds.


CONCLUSIONS
For GDM identified in a 2-step procedure, our findings support the use of isolated abnormal fasting values according to the ADA threshold in identifying women who could benefit from treatment.
Division of Research, Kaiser Permanente of Northern California, Oakland, CA, USA.
Samantha F
SF
Ehrlich
Yvonne M
YM
Crites
Monique M
MM
Hedderson
Jeanne A
JA
Darbinian
Assiamira
A
Ferrara
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology* / Q000209:etiology; D005865:Gestational Age; D018149:Glucose Intolerance; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D008875:Middle Aged; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
D001786:Blood Glucose
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