Diffusion tensor imaging of incentive effects in prospective memory after pediatric traumatic brain injury.
Few studies exist investigating the brain-behavior relations of event-based prospective memory (EB-PM) impairments following traumatic brain injury (TBI). To address this, children with moderate-to-severe TBI performed an EB-PM test with two motivational enhancement conditions and underwent concurrent diffusion tensor imaging (DTI) at 3 months post-injury. Children with orthopedic injuries (OI; n=37) or moderate-to-severe TBI (n=40) were contrasted. Significant group differences were found for fractional anisotropy (FA) and apparent diffusion coefficient for orbitofrontal white matter (WM), cingulum bundles, and uncinate fasciculi. The FA of these WM structures in children with TBI significantly correlated with EB-PM performance in the high, but not the low motivation condition. Regression analyses within the TBI group indicated that the FA of the left cingulum bundle (p=0.003), left orbitofrontal WM (p<0.02), and left (p<0.02) and right (p<0.008) uncinate fasciculi significantly predicted EB-PM performance in the high motivation condition. We infer that the cingulum bundles, orbitofrontal WM, and uncinate fasciculi are important WM structures mediating motivation-based EB-PM responses following moderate-to-severe TBI in children.
Physical Medicine and Rehabilitation Alliance of Baylor College of Medicine and University of Texas-Houston Medical School, Houston, Texas, USA. mccauley@bcm.edu
Stephen R
SR
McCauley
Elisabeth A
EA
Wilde
Erin D
ED
Bigler
Zili
Z
Chu
Ragini
R
Yallampalli
Margaret B
MB
Oni
Trevor C
TC
Wu
Marco A
MA
Ramos
Claudia
C
Pedroza
Ana C
AC
Vásquez
Jill V
JV
Hunter
Harvey S
HS
Levin
D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology* / Q000523:psychology; D001931:Brain Mapping; D002648:Child; D056324:Diffusion Tensor Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015601:Injury Severity Score; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000502:physiology*; D009042:Motivation; D009413:Nerve Fibers, Myelinated; D009483:Neuropsychological Tests; D012044:Regression Analysis
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