Nontypeable Streptococcus pneumoniae as an otopathogen.
Among 34 Streptococcus pneumoniae (Spn) sequential isolates from middle ear fluid, we found a case of a nontypeable S. pneumoniae (NT-Spn) in a child with acute otitis media (AOM). The strain was pneumolysin PCR positive and capsule gene PCR negative. Virulence of the NT-Spn was confirmed in a chinchilla model of AOM.
Rochester General Hospital Research Institute, Rochester, NY 14621, USA.
Qingfu
Q
Xu
Ravinder
R
Kaur
Janet R
JR
Casey
Vishakha
V
Sabharwal
Stephen
S
Pelton
Michael E
ME
Pichichero
D000208:Acute Disease; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D015373:Bacterial Typing Techniques; D002682:Chinchilla / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D058885:Multilocus Sequence Typing; D010033:Otitis Media / Q000382:microbiology*; D010802:Phylogeny; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D013301:Streptolysins / Q000235:genetics
D001426:Bacterial Proteins; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae
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