Structure, bioactivity and synthesis of natural products with hexahydropyrrolo[2,3-b]indole.
Research on natural products containing hexahydropyrrolo[2,3-b]indole (HPI) has dramatically increased during the past few years. Newly discovered natural products with complex structures and important biological activities have recently been isolated and synthesized. This review summarizes the structures, biological activities, and synthetic routes for natural compounds containing HPI, emphasizing the different strategies for assembling this motif. It covers a broad range of molecules, from small alkaloids to complex peptides.
Institute for Research in Biomedicine, Barcelona Science Park, Baldiri i Reixac 10, 08028 Barcelona, Spain.
Pau
P
Ruiz-Sanchis
Svetlana A
SA
Savina
Fernando
F
Albericio
Mercedes
M
Álvarez
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry
D000470:Alkaloids; D001688:Biological Products; D006571:Heterocyclic Compounds; D007211:Indoles; D010455:Peptides