Epigenetic memory meets G2/M: to remember or to forget?
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 is essential for stem cell maintenance and proliferation. Recent insights suggest that the cyclin-dependent kinase CDK1 phosphorylates EZH2 at specific threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M phase.
RIKEN Center for Allergy and Immunology, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan.
Jafar
J
Sharif
Mitsuhiro
M
Endoh
Haruhiko
H
Koseki
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D057890:Epigenomics; D016195:G2 Phase / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D008954:Models, Biological; D010766:Phosphorylation; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
D006657:Histones; D014157:Transcription Factors; D018844:Cyclin-Dependent Kinases