Interleukin (Il)-12, Il-5 and total IgE in hepatosplenic schistosomiasis with or without asthma.
There are a number of similarities between protective immune responses against schistosomiasis and asthma. Both are associated with elevated concentrations of IgE and eosinophilia. Chronic schistosomiasis is liked to Th1 like response with involvement of pro-inflammatory cytokines in schistosomal hepatosplenic disease process resulting in low level of IL-5. Meanwhile, association with asthma could modulate the immune response with shift to Th2 side resulting in marked elevation of IL-5 and eosinophilia. This work evaluated the levels of serum IgE, IL-5 and IL-12 in Schistosoma mansoni-infected asthmatic patients. A total of 100 subjects selected from Al-Azhar University's Hospitals were divided into three groups GI: 50 patients with hepatosplenic schistosomiasis associated with asthma. GII: 25 patients with hepatosplenic schistosomiasis without apparent asthma. GIII: 25 patients with neither bilharzial liver cirrhosis nor asthma as control group. All patients were subjected to full history taking and clinical examination, pulmonary function tests, total serum IgE, bilharzial antibody titre, stool and urine examination for parasites, liver function tests and serum IL-5 and IL-12. The results showed very high level of the total serum IgE in GI and GII compared to GIII. There was high significant difference in peripheral blood eosinophil%. GI & GII gave highest levels, IL-5 was elevated in GI, but low GII, I-12 was high in GII than GI.
Departmentof General Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Cairo, Egypt.
Mahmoud H
MH
Hemida
Nabeel Salama
NS
Mahmoud
Metwally Mohamed Tolba
MM
El
El Sayed Gaber
el SG
Ammar
Yasser Fouad
YF
Kilany
Tiby Deiaa M
TD
El
Dahshan Tarek A
DT
El
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D001249:Asthma / Q000150:complications / Q000378:metabolism*; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D018664:Interleukin-12 / Q000097:blood*; D015848:Interleukin-5 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010063:Ovum; D012547:Schistosoma / Q000502:physiology; D012552:Schistosomiasis / Q000150:complications / Q000378:metabolism* / Q000652:urine
D000913:Antibodies, Protozoan; D015848:Interleukin-5; D018664:Interleukin-12; D007073:Immunoglobulin E