Understanding how hepatitis C virus builds its unctuous home.
Hepatitis C virus genome replication occurs in endoplasmic reticulum-derived membrane compartments, but it is unknown how these structures arise. In this issue of Cell Host & Microbe, Reiss and colleagues (2011) show that the virus recruits a specific lipid kinase to replication sites, stimulates its kinase activity, and alters the phospholipid profile of replication compartments.
Section of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, BCMM 354C, New Haven, CT 06536, USA. brett.lindenbach@yale.edu
Brett D
BD
Lindenbach
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16410-5
19717417
J Virol. 2009 Oct;83(19):10058-74
19605471
J Virol. 2009 Sep;83(18):9237-46
19570870
Nature. 2010 May 6;465(7294):96-100
20410884
Cell. 2010 May 28;141(5):799-811
20510927
Virology. 2009 Apr 25;387(1):5-10
19304308
Nat Rev Microbiol. 2007 Jun;5(6):453-63
17487147
Proc Natl Acad Sci U S A. 2009 May 5;106(18):7577-82
19376974
Cell Host Microbe. 2009 Mar 19;5(3):298-307
19286138
J Virol. 2005 Nov;79(21):13594-605
16227280