Polycystic ovary syndrome and increased polyp numbers as risk factors for malignant transformation of endometrial polyps in premenopausal women.
OBJECTIVE
To determine the pre-malignant and malignant potential of endometrial polyps and to assess whether different clinical parameters are associated with malignancy in the polyps of premenopausal women.


METHODS
The clinical records of operative office hysteroscopic and resectoscopic procedures for endometrial polyps in 417 premenopausal women who attended Baskent University were examined over a retrospective period of 30 months. Only premenopausal patients were included in the study.


RESULTS
In 97.8% of women, histology showed benign endometrial pathology. In 2.2% of women, pre-malignant or malignant conditions were found in the polyp. Polycystic ovary syndrome (PCOS) and the presence of 2 or more polyps were associated with significant pre-malignant or malignant changes.


CONCLUSIONS
The presence of irregular vaginal bleeding was not a predictor of malignancy in the polyp. Premenopausal women with PCOS and those with 2 or more polyps had an increased prevalence of polyp malignancy. These groups of patients, whether symptomatic or not, should be evaluated by hysteroscopic resection of the polyps.
Department of Obstetrics and Gynecology, Division of Reproductive and Endocrinology Unit, Faculty of Medicine, Baskent University, Adana, Turkey.
Esra B
EB
Kilicdag
Bulent
B
Haydardedeoglu
Tayfun
T
Cok
Ayse H
AH
Parlakgumus
Erhan
E
Simsek
Filiz A
FA
Bolat
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D018194:Adenomyoma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000453:epidemiology*; D011127:Polyps / Q000150:complications / Q000453:epidemiology* / Q000601:surgery; D011230:Precancerous Conditions / Q000150:complications; D017697:Premenopause; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors