Cardiac biomarkers in the diagnosis, prognosis and management of coronary artery disease: a primer for internists.
Initially coined in 1989, biomarkers have become a cornerstone of modern cardiovascular medicine. The past decade has borne witness to the rapid transition of cardiac biomarkers from bench to bedside in the management of patients with coronary artery disease. The implementation of cardiac biomarkers has transformed the internists' approach to cardiovascular patients. This article reviews several cardiac biomarkers in the context of diagnosis, prognosis, risk-assessment and management of patients at risk of adverse cardiovascular outcomes. Biomarkers are presented according to their relevant role in the atherosclerotic cascade, a pathologic classification of particular value for internists, as it defines the role of these agents in the pathogenesis of heart disease. Where pertinent, limitations of cardiac biomarkers are discussed, thus allowing the discerning practitioner to remain cognizant of situations that may lead to spurious marker elevation or suppression. The review concludes with highlights on novel avenues of biomarker research that promise an exciting future for these entities.
Department of Internal Medicine, Divisions of General Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA. vineetc@med.umich.edu
Vineet
V
Chopra
Kim A
KA
Eagle
D015415:Biomarkers / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D002309:Cardiology / Q000193:education; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D019468:Disease Management; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D017270:Lipoprotein(a) / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism
D015415:Biomarkers; D017270:Lipoprotein(a); D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D006710:Homocysteine; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein; D009195:Peroxidase; D020780:Matrix Metalloproteinase 9