A Review of Fatalities Reported as Associated with NSAID Treatment in Ontario.
This article reviews reports of 61 deaths associated with non-steroidal anti-inflammatory drugs (NSAIDs). These fatalities occurred in Ontario, between February 1, 1981 and January 1, 1986. The average age of these patients at death was 78.6 years, and 59% were female. One or more gastro-intestinal hemorrhages preceded death in 48 patients (79%), and perforation of ulcers with peritonitis and shock were reported in five cases. Other reports indicated that edema and renal failure had occurred in three patients, and bone-marrow depression in another three. The NSAIDs most frequently implicated in these deaths were piroxicam and naproxen, but without data on the numbers of patients taking the various NSAIDs, no conclusions can be drawn about the relative frequencies of severe reactions.
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Brennan
Can Med Assoc J. 1984 Aug 1;131(3):189-91
6744164
N Z Med J. 1984 Oct 24;97(766):729-32
6239993
Drugs. 1984 Mar;27(3):232-55
6368185
Age Ageing. 1984 Sep;13(5):295-8
6333782
JAMA. 1975 Dec 22;234(12):1236-41
1242749
Br Med J (Clin Res Ed). 1985 Mar 23;290(6472):932-3
3919846
Eur J Rheumatol Inflamm. 1983;6(1):3-23
6345166
Fam Pract. 1984 Mar;1(1):30-6
6530060
Drugs. 1984 Oct;28(4):292-323
6386426
Can Med Assoc J. 1985 Jan 1;132(1):19-23
3871167
Br Med J (Clin Res Ed). 1985 Feb 2;290(6465):347-9
3917814
Clin Pharmacol Ther. 1985 Jan;37(1):13-8
3965234
Br Med J (Clin Res Ed). 1985 Mar 9;290(6470):787-8
3918755
Clin Pharmacol Ther. 1981 Aug;30(2):239-45
7249508
Br Med J (Clin Res Ed). 1985 Jan 12;290(6462):117
3917708
Br Med J. 1980 Jan 12;280(6207):75-8
7353130