Post-transplant lymphoproliferative disorders: clinicopathological analysis of 43 cases in a single center, 1990-2009.
Post-transplant lymphoproliferative disorders (PTLDs) are a heterogeneous set of complications of organ transplantation associated with poor patient prognosis. We analyzed the clinicopathological features of PTLDs in 43 adult and pediatric recipients of solid organ or bone marrow transplantation at a large transplant service in the Republic of Korea between 1990 and 2009. Of 4545 solid organ and 747 bone marrow transplant recipients, 37 (0.81%) and 6 (0.8%), respectively, developed heterogeneous types of PTLDs. The cumulative incidences of PTLDs during this period were 1.79% (4/223) for heart transplant recipients, 0.78% (17/2192) for kidney transplant recipients, and 0.77% (16/2067) for liver transplant recipients. The patterns of disease onset, histology, and patient survival were associated with the types of organs transplanted. There is a trend for shorter overall survival (OS) in recipients with early-onset PTLDs and monomorphic PTLD histology, while kidney transplant recipients showed favorable OS. This study may be the first comprehensive analysis of the characteristics of PTLDs in Korean patients.
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sun Och
SO
Yoon
Eunsil
E
Yu
Yong Mee
YM
Cho
Cheolwon
C
Suh
Kyung Mo
KM
Kim
Duck Jong
DJ
Han
Seung Gyu
SG
Lee
Jooryung
J
Huh
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects* / Q000401:mortality; D011183:Postoperative Complications; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D015996:Survival Rate; D013997:Time Factors; D055815:Young Adult