Benzodiazépines: dépendance et approche thérapeutique pour un retrait graduel.
The extensive use of benzodiazepines in treating anxiety and insomnia makes clinicians ask themselves about the risk of addiction relating to these drugs.(1-3) Indeed, it is estimated that in Canada, the United-States, and Western Europe, between 10% and 20% of persons use tranquilizers or hypnotics (mostly benzodiazepines) during a one-year period. Of these persons 70% are 50 years of age or more. It has been noted that 15% of those persons have been using these drugs for more than 12 months.(4, 5) In 1980, Tyrer reported that 50% of the patients who receive a prescription for benzodiazepines renew that prescription without consulting their physician.(6) In this article, the authors briefly review the dependency, risk factors and clinical signs resulting from withdrawal of these drugs. They also define a rational therapeutic approach to discontinuing their use.
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Br Med J (Clin Res Ed). 1985 Nov 23;291(6507):1507
3933729
Br Med J (Clin Res Ed). 1981 Sep 5;283(6292):643-5
6114776
Can Med Assoc J. 1982 Dec 1;127(11):1093-6
7139456
N Engl J Med. 1986 Oct 2;315(14):854-9
3092053
Am Fam Physician. 1984 Nov;30(5):139-47
6149682
Med J Aust. 1986 May 26;144(11):594-7
2872582
Postgrad Med J. 1984;60 Suppl 2:29-40
6463009
Psychopharmacol Bull. 1985;21(1):91-2
2858908
Am J Psychiatry. 1984 Jul;141(7):848-52
6145363
Lancet. 1981 Mar 7;1(8219):520-2
6111632
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):669-73
6141609
Clin Pharmacol Ther. 1984 Oct;36(4):527-33
6434221
Br Med J (Clin Res Ed). 1985 Sep 14;291(6497):688-90
2864096
Lancet. 1983 Jun 25;1(8339):1402-6
6134180
Drugs. 1983 May;25(5):514-28
6134609
Br Med J (Clin Res Ed). 1985 Oct 26;291(6503):1201-2
3931850
Drugs. 1983 Apr;25(4):385-98
6133736
Br Med J (Clin Res Ed). 1984 Apr 14;288(6424):1135-40
6143582
Br Med J (Clin Res Ed). 1985 May 11;290(6479):1374-6
3922500