Platelet-rich plasma: a promising product for treatment of peripheral nerve regeneration after nerve injury.
Nerve regeneration includes regrowth of injured axons as well as myelination, restoration of synaptic connections and recovery of physiological functions. Platelet-rich plasma (PRP) is prepared from the patient's own blood and contains growth factors that influence wound healing and used in various surgical fields including oral and maxillofacial surgery. When platelets are activated either ex vivo or in vivo, growth factors and proteins were released from platelets' alpha granules. Recent studies proved that PRP could promote regeneration of injured peripheral nerve. This review focuses on current trials using PRP to promote nerve regeneration and repairment, and proposes potential clinical application of PRP for nerve injury in the future.
Division of Hematology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, China.
WenJun
W
Yu
Jian
J
Wang
Jun
J
Yin
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009410:Nerve Degeneration / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D009416:Nerve Regeneration / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D053657:Platelet-Rich Plasma / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology