Rallying the exocyst as an autophagy scaffold.
Protein scaffolds coordinate the assembly of many multicomponent signaling complexes. Bodemann et al. (2011) now show that the exocyst, a protein complex involved in tethering transport vesicles to the plasma membrane, provides an assembly and activation platform for components of the autophagy machinery via a process requiring the GTPase RalB.
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0322, USA.
Jean-Claude
JC
Farré
Suresh
S
Subramani
Nat Struct Mol Biol. 2006 Jul;13(7):577-81
16826234
Curr Opin Cell Biol. 2010 Apr;22(2):124-31
20034776
Nat Rev Cancer. 2008 Feb;8(2):133-40
18219307
Cell Res. 2010 Jul;20(7):748-62
20548331
J Biol Chem. 2003 Dec 19;278(51):51743-8
14525976
Nat Cell Biol. 2002 Jan;4(1):66-72
11740492
Nat Rev Immunol. 2009 Jan;9(1):47-56
19104498
Cell. 2006 Oct 6;127(1):157-70
17018283
Curr Opin Cell Biol. 2009 Aug;21(4):537-42
19473826
Cell. 2011 Jan 21;144(2):253-67
21241894