Isoswertisin flavones and other constituents from Peperomia obtusifolia.
A phytochemical investigation of the leaves and stems of Peperomia obtusifolia (Piperaceae) yielded a new flavone C-diglycoside isoswertisin-4'-methyl-ether-2''α-L-rhamnoside (1), along with four known compounds: isoswertisin-2''α-L-rhamnoside (2), (+)-diayangambin (3), 2-episesalatin (4) and corchoionoside C (5). The structures of the two flavone C-diglycosides (1, 2) were elucidated on the basis of 1D and 2D NMR spectroscopy and MS spectrometric data. These flavones were evaluated by bioautographic assay against Cladosporium cladosporioides and C. sphaerospermum and showed weak antifungal activity.
Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP, Brazil.
Jonas da S
Jda S
Mota
Ana C
AC
Leite
Massuo J
MJ
Kato
Maria Claudia M
MC
Young
Vanderlan da S
Vda S
Bolzani
Maysa
M
Furlan
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000493:pharmacokinetics; D002963:Cladosporium / Q000187:drug effects; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D036941:Peperomia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*
D000935:Antifungal Agents; D047309:Flavones; D006027:Glycosides; D010936:Plant Extracts; C560349:isoswertisin-4'-methyl-ether-2''alpha-L-rhamnoside