Reduced interhemispheric resting state functional connectivity in cocaine addiction.
BACKGROUND
Models of cocaine addiction emphasize the role of disrupted frontal circuitry supporting cognitive control processes. However, addiction-related alterations in functional interactions among brain regions, especially between the cerebral hemispheres, are rarely examined directly. Resting-state functional magnetic resonance imaging (fMRI) approaches, which reveal patterns of coherent spontaneous fluctuations in the fMRI signal, offer a means to quantify directly functional interactions between the hemispheres. We examined interhemispheric resting-state functional connectivity (RSFC) in cocaine dependence using a recently validated approach, voxel-mirrored homotopic connectivity.


METHODS
We compared interhemispheric RSFC between 25 adults (aged 35.0 ± 8.8) meeting DSM-IV criteria for cocaine dependence within the past 12 months but currently abstaining (>2 weeks) from cocaine and 24 healthy comparisons (35.1 ± 7.5), group-matched on age, sex, education, and employment status.


RESULTS
We observed reduced prefrontal interhemispheric RSFC in cocaine-dependent participants relative to control subjects. Further analyses demonstrated a striking cocaine-dependence-related reduction in interhemispheric RSFC among nodes of the dorsal attention network, comprising bilateral lateral frontal, medial premotor, and posterior parietal areas. Further, within the cocaine-dependent group, RSFC within the dorsal attention network was associated with self-reported attentional lapses.


CONCLUSIONS
Our findings provide further evidence of an association between chronic exposure to cocaine and disruptions within large-scale brain circuitry supporting cognitive control. We did not detect group differences in diffusion tensor imaging measures, suggesting that alterations in the brain's functional architecture associated with cocaine exposure can be observed in the absence of detectable abnormalities in the white matter microstructure supporting that architecture.
Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience at the New York University Child Study Center, New York, New York 10016, USA. clare.kelly@nyumc.org
Clare
C
Kelly
Xi-Nian
XN
Zuo
Kristin
K
Gotimer
Christine L
CL
Cox
Lauren
L
Lynch
Dylan
D
Brock
Davide
D
Imperati
Hugh
H
Garavan
John
J
Rotrosen
F Xavier
FX
Castellanos
Michael P
MP
Milham
D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000209:etiology; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D001931:Brain Mapping; D019970:Cocaine-Related Disorders / Q000150:complications / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D012146:Rest / Q000502:physiology*; D013223:Statistics as Topic
Magn Reson Med. 2003 Jan;49(1):177-82
12509835
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):937-46
16087438
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
11293691
Neuroimage. 2011 Jan 1;54(1):517-27
20570737
Int J Psychophysiol. 2008 Jan;67(1):35-40
18029040
J Neurosci. 2009 Jun 3;29(22):7364-78
19494158
Perspect Psychol Sci. 2009 May;4(3):274-90
26158964
Annu Rev Psychol. 2009;60:173-96
19035823
Neuroimage. 2009 Apr 1;45(2):614-26
19110061
Neurosci Lett. 2010 May 7;475(1):20-4
20302912
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3125-35
18640910
Trends Cogn Sci. 2010 Apr;14(4):180-90
20206576
J Neurosci. 2006 Jun 14;26(24):6469-72
16775134
Neuroimage. 2010 Aug 15;52(2):590-9
20441798
Neuron. 2008 Oct 9;60(1):174-88
18940597
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11073-8
17576922
Neuroimage. 2010 Nov 1;53(2):593-601
20603217
Neuroimage. 2010 May 1;50(4):1690-701
20079856
J Neurosci. 2007 Nov 14;27(46):12500-5
18003828
Cereb Cortex. 2008 Nov;18(11):2553-9
18296434
J Neurosci. 2008 Dec 17;28(51):13754-64
19091966
Neuroimage. 2003 Jul;19(3):1095-102
12880835
Nat Rev Neurosci. 2002 Mar;3(3):201-15
11994752
Ann Neurol. 2010 Mar;67(3):365-75
20373348
Neuron. 2003 Dec 4;40(5):885-95
14659088
Br J Clin Psychol. 1982 Feb;21(1):1-16
7126941
Am J Addict. 2004 Jan-Feb;13(1):74-82
14766440
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
20176931
Drug Alcohol Depend. 2008 Jan 1;92(1-3):164-72
17904770
Neuron. 2007 Mar 15;53(6):905-18
17359924
Trends Cogn Sci. 2008 Mar;12(3):99-105
18262825
Drug Alcohol Depend. 2009 Oct 1;104(3):262-7
19595517
Psychiatry Res. 2009 Mar 31;171(3):242-51
19217266
J Neurosci. 2010 Nov 10;30(45):15034-43
21068309
Addiction. 2008 Jul;103(7):1069-81
18494843
Neuropsychopharmacology. 2010 Jan;35(1):217-38
19710631
Neuropsychopharmacology. 2010 Jun;35(7):1541-9
20393459
Brain. 2000 Jul;123 ( Pt 7):1293-326
10869045
Proc Biol Sci. 1998 Nov 22;265(1411):2141-8
9872002
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5
19620724
Addict Behav. 1998 Jul-Aug;23(4):449-61
9698974
Neuroimage. 2001 Jul;14(1 Pt 1):21-36
11525331
Assessment. 2009 Jun;16(2):145-58
19066391
Neuroimage. 2006 Jul 15;31(4):1487-505
16624579
Neuropsychopharmacology. 2005 Mar;30(3):610-7
15637640
Brain Res. 2009 Oct 27;1295:149-58
19666011
Drug Alcohol Depend. 2009 Jun 1;102(1-3):88-94
19264428
J Subst Abuse Treat. 1999 Mar;16(2):129-35
10023610
Neuropsychologia. 1999 Jun;37(6):661-70
10390027
Neuropsychopharmacology. 2007 Oct;32(10):2229-37
17299505
Nat Rev Neurosci. 2004 Dec;5(12):963-70
15550951
Comput Biomed Res. 1996 Jun;29(3):162-73
8812068
Arch Phys Med Rehabil. 2006 Dec;87(12 Suppl 2):S20-9
17140876
J Neurosci. 2010 Mar 17;30(11):3964-72
20237267
Nat Neurosci. 2005 Nov;8(11):1458-63
16251988
Neuroimage. 2010 Jan 1;49(1):738-44
19703568
Psychol Bull. 1994 Sep;116(2):195-219
7972590
Nature. 2007 May 3;447(7140):83-6
17476267
Biol Psychiatry. 2002 Jan 15;51(2):134-42
11822992
Neuroimage. 2004;23 Suppl 1:S208-19
15501092
Cereb Cortex. 2011 May;21(5):1134-46
20943668
Trends Mol Med. 2006 Dec;12(12):559-66
17070107
Neuropsychol Rev. 2007 Sep;17(3):337-45
17680368
Cereb Cortex. 2008 Dec;18(12):2735-47
18400794
Soc Cogn Affect Neurosci. 2009 Jun;4(2):208-13
19470529
J Neurosci. 2003 Aug 13;23(19):7407-11
12917376
Biol Psychiatry. 2002 Jun 1;51(11):890-5
12022962
Pharmacol Biochem Behav. 2008 Nov;91(1):155-64
18674556
Nat Neurosci. 2009 May;12(5):535-40
19396166
Trends Cogn Sci. 2005 Apr;9(4):195-201
15808502
Neuropsychologia. 1971 Mar;9(1):97-113
5146491
Psychiatry Res. 2010 Jan 30;181(1):15-23
19959345
Am J Psychiatry. 2002 Oct;159(10):1642-52
12359667
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10046-51
16788060
Brain Cogn. 1998 Mar;36(2):128-57
9520311
Magn Reson Med. 2000 Aug;44(2):259-68
10918325
PLoS One. 2010 May 25;5(5):e10815
20520835
Arch Gen Psychiatry. 2009 Apr;66(4):431-41
19349313
Nat Neurosci. 2010 Apr;13(4):507-12
20208526
Neuropsychopharmacology. 2006 Apr;31(4):872-84
16192989
Magn Reson Med. 2000 Jan;43(1):45-51
10642730
Psychol Aging. 2002 Mar;17(1):85-100
11931290
Addiction. 2007 Apr;102 Suppl 1:33-43
17493051
Neuropsychologia. 1997 Jun;35(6):747-58
9204482
Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3257-66
18640916
Psychiatry Res. 2010 Jan 30;181(1):57-63
19959341
Psychiatry Res. 1995 Oct 16;58(3):247-57
8570780