Progressive supranuclear palsy: new concepts.
Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum, oculomotor nucleus, medulla and dentate nucleus. Over the last decade many lines of investigations have helped refine PSP in many aspects and it is the purpose of this review to help neurologists identify PSP, to better understand its pathophysiology and to provide a more focused, symptom-based treatment approach.
Department of Neurology and Neurosurgery, Federal University of São Paulo, SP, Brazil. orlandobarsottini@gmail.com
Orlando Graziani Povoas
OG
Barsottini
André Carvalho
AC
Felício
Camila Catherine Henriques de
CC
Aquino
José Luiz
JL
Pedroso
D006801:Humans; D013494:Supranuclear Palsy, Progressive / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy