The dose response of chromosome aberrations in human lymphocytes induced in vitro by very low-dose γ rays.
This paper considers the dose-effect relationship for unstable chromosome aberration yields in human lymphocytes in very low-dose range. Data are presented for (60)Co γ-ray doses of 0, 10, 20, 40 and 1000 mGy. More than 5,000 metaphases were scored for each data point at the very low doses, and each cell was double-checked using a semi-automated metaphase finding/relocation system. Aberration yields of dicentrics plus centric rings followed an excellent linear dose response down to zero dose; the yields were significantly above the control frequency from 20 mGy.
Central Research Institute of Electric Power Industry, 2-11-1 Iwadokita, Komae-shi, Tokyo, Japan. iwasakit@criepi.denken.or.jp
Toshiyasu
T
Iwasaki
Yoshio
Y
Takashima
Toshikazu
T
Suzuki
Mitsuaki A
MA
Yoshida
Isamu
I
Hayata
D002869:Chromosome Aberrations / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008677:Metaphase