Variant Plasmodium ovale isolated from a patient infected in Ghana.
Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes. This study presents a P. ovale isolate from a patient infected in Ghana together with an analysis of the small subunit RNA, cytochrome b, cytochrome c oxidase I, cysteine protease and lactate dehydrogenase genes, which show that the sample is a variant P. ovale and identical or highly similar to variant P. ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon. The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago.
Department of Infectious Diseases, Institute of Clinical Medicine, Aarhus University Hospital-Skejby, Aarhus N., Denmark.
David
D
Tordrup
Jakob
J
Virenfeldt
Felicie F
FF
Andersen
Eskild
E
Petersen
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002738:Chloroquine / Q000031:analogs & derivatives / Q000627:therapeutic use; D057056:Cysteine Proteases / Q000235:genetics; D045303:Cytochromes b / Q000235:genetics; D003718:Denmark; D003576:Electron Transport Complex IV / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D005869:Ghana; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000235:genetics; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D002679:Pan troglodytes / Q000469:parasitology; D010802:Phylogeny; D041122:Plasmodium ovale / Q000145:classification / Q000235:genetics* / Q000502:physiology; D011319:Primaquine / Q000627:therapeutic use; D016053:RNA, Protozoan / Q000235:genetics; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D016415:Sequence Alignment
D000962:Antimalarials; D016053:RNA, Protozoan; D012337:RNA, Ribosomal, 18S; C023676:chloroquine diphosphate; D002738:Chloroquine; D045303:Cytochromes b; D007770:L-Lactate Dehydrogenase; D003576:Electron Transport Complex IV; D057056:Cysteine Proteases; D011319:Primaquine
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