Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection.
Extranodal marginal zone B-cell lymphomas are linked to bacterial infections that vary according to the anatomical site. The occurrence of these lymphomas in the central nervous system is a very rare event, and the identification of specific bacteria in this setting has not been previously addressed. Herein, we report for the first time a case of primary central nervous system marginal zone B-cell lymphoma involving the choroid plexus associated with Chlamydophila psittaci infection. No concomitant ocular involvement was detected. C psittaci was identified with 3 independent methods, and through immunohistochemistry, it was visualized in the cytoplasm of monocytes/macrophages present within lymphomatous tissues. This observation points toward the opportunity to investigate the prevalence of C psittaci infection in central nervous system lymphomas, particularly in those with low-grade histologic features.
Pathology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy. ponzoni.maurilio@hsr.it
Maurilio
M
Ponzoni
Fausta
F
Bonetti
Pier Luigi
PL
Poliani
William
W
Vermi
Chiara
C
Bottelli
Riccardo
R
Dolcetti
Maria Giulia
MG
Cangi
Andrés J M
AJ
Ferreri
Elena Dal
ED
Cin
Elisa
E
Pasini
Roberto
R
Liserre
Claudio
C
Doglioni
Giuseppe
G
Rossi
Fabio
F
Facchetti
D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000382:microbiology*; D023521:Chlamydophila Infections / Q000150:complications* / Q000175:diagnosis; D002691:Chlamydophila psittaci / Q000302:isolation & purification; D002831:Choroid Plexus / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000382:microbiology*; D008279:Magnetic Resonance Imaging; D013194:Staining and Labeling