Preparation of polyester-based metal-cross linked polymeric composites as novel materials resistant to bacterial adhesion and biofilm formation.
Bacterial biofilms constitute an extremely resistant form of bacterial colonization with dire health and economical implications. Towards achieving polymeric composites capable of resisting bacterial adhesion and biofilm formation, we prepared five 2,6-pyridinedicarboxylate-based polyesters employing five different diol monomers. The resulting polyesters were complexed with copper (II) or silver (I). The new polymers were characterized by proton and carbon nuclear magnetic resonance spectroscopy, inherent viscosity, infrared spectroscopy, differential scanning calorimetry and thermogravimetric analysis. The corresponding metal complexes were characterized by differential scanning calorimetry and infrared spectroscopy. The amounts of complexed copper and silver were determined by atomic absorption spectrophotometry. Finally, the resulting composites were tested for their antibacterial potential and were found to effectively resist bacterial attachment and growth.
Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, Jordan.
Suhair
S
Saleh
Bassam
B
Sweileh
Sami O
SO
Taha
Ruhaifa
R
Mahmoud
Mutasem O
MO
Taha
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms; D002152:Calorimetry, Differential Scanning; D019906:Nuclear Magnetic Resonance, Biomolecular; D011091:Polyesters / Q000737:chemistry*; D013054:Spectrophotometry, Atomic; D013818:Thermogravimetry
D000900:Anti-Bacterial Agents; D011091:Polyesters
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