APS--controversies in diagnosis and management, critical overview of current guidelines.
Because the diagnosis of antiphospholipid syndrome is based on laboratory data, performance and interpretation of such tests is essential. Positivity in a single test among Lupus Anticoagulant (LA), anti cardiolipin (aCL) and anti β2-glycoprotein I (aβ2GPI) antibodies calls APS diagnosis into question. Conversely, triple positivity is strongly associated to thrombosis and pregnancy morbidity. A new era in studying APS should take into account different antiphospholipid antibodies profiles. Clinical studies on groups of patients that are homogeneous in terms of laboratory tests will provide information on the real risk of patients and on the real effect of therapeutic interventions.
Clinical Cardiology, Thrombosis Center, University of Padova School of Medicine, Padova, Italy. vittorio.pengo@unipd.it
Vittorio
V
Pengo
D017152:Antibodies, Antiphospholipid / Q000276:immunology; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D017410:Practice Guidelines as Topic
D017152:Antibodies, Antiphospholipid; D000925:Anticoagulants