Renal inflammation, autoimmunity and salt-sensitive hypertension.
1. The present article reviews the role of immune-competent cells infiltrating the kidney and their association with oxidative stress and renal angiotensin activity in the development of salt-sensitive hypertension. 2. We discuss changes in the pressure-natriuresis relationship resulting from renal inflammation and its improvement resulting from immunosuppressive treatment. 3. The potential role of T-cell-driven reactivity in sustaining the renal inflammation is examined in the light of accumulating evidence of autoimmune mechanisms in experimental and clinical hypertension.
Renal Service, University Hospital, University of Zulia and Venezuelan Institute of Scientific Research-Zulia, Maracaibo, Estado Zulia, Venezuela. brodrigueziturbe@gmail.com
Bernardo
B
Rodríguez-Iturbe
Martha
M
Franco
Edilia
E
Tapia
Yasmir
Y
Quiroz
Richard J
RJ
Johnson
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D015551:Autoimmunity; D018840:HSP70 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D007684:Kidney Tubules / Q000276:immunology / Q000503:physiopathology; D008264:Macrophages / Q000276:immunology; D009318:Natriuresis; D009393:Nephritis / Q000503:physiopathology*; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000276:immunology; D018834:Chaperonin 60; D024101:Mitochondrial Proteins
D001323:Autoantibodies; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D017673:Sodium Chloride, Dietary; C060293:HSPD1 protein, human; D018834:Chaperonin 60; D024101:Mitochondrial Proteins
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