Are polycomb group bodies gene silencing factories?
Polycomb group (PcG) proteins mediate long-range associations between Hox genes, which correlate with gene repression in vivo. Bantignies et al. (2011) identify a physiological role for the nuclear localization of Hox genes in PcG-mediated gene silencing, strengthening the evidence that nuclear positioning regulates gene expression.
Department of Zoology, University of British Columbia, Vancouver BC, Canada.
Jacob W
JW
Hodgson
Hugh W
HW
Brock