RADSeq: next-generation population genetics.
Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA sequencing, a method that samples at reduced complexity across target genomes, promises to deliver high resolution population genomic data-thousands of sequenced markers across many individuals-for any organism at reasonable costs. It has found application in wild populations and non-traditional study species, and promises to become an important technology for ecological population genomics.
Institute of Evolutionary Biology, Edinburgh, UK. john.davey@ed.ac.uk
John W
JW
Davey
John L
JL
Davey
Mark L
ML
Blaxter
Mark W
MW
Blaxter
D000818:Animals; D001483:Base Sequence; D014644:Genetic Variation; D005828:Genetics, Population; D016678:Genome; D006801:Humans; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D015183:Restriction Mapping; D017422:Sequence Analysis, DNA / Q000379:methods*
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