The First Description of Docetaxel-Induced Recall Inflammatory Skin Reaction After Previous Drug Extravasation.
OBJECTIVE
To describe a cutaneous recall soft tissue injury at the site of previous extravasation of docetaxel.


METHODS
A 65-year-old white female with an invasive ductal carcinoma of the right breast was treated with carboplatin AUC 2 and docetaxel 30 mg/m(2) weekly via a peripheral vein access. During the 14th cycle, drug extravasation of docetaxel occurred in the left antecubital fossa characterized by a mild erythema without edema. A severe erythema developed in the former area of extravasation after the 15th cycle of carboplatin/docetaxel. The recall dermatitis continued to exacerbate after each course of systemic docetaxel chemotherapy and finally led to termination of this therapy.


CONCLUSIONS
In general, extravasation of docetaxel causes only mild local skin reactions without further necessity of intervention. For pegylated liposomal doxorubicin and paclitaxel, inflammatory recall phenomena at sites of previous drug extravasation are rare and often occur as single events following administration of the same cytotoxic drug. According to the Naranjo probability scale, the administration of docetaxel in this case probably led to the cutaneous soft tissue injury as a result of extravasation.


CONCLUSIONS
Caution is needed after an episode of docetaxel extravasation. Even after a therapy interruption of several weeks, resumption of chemotherapy with docetaxel might lead to recrudescence of the inflammatory skin reaction.
Frauke Kramer MD, Resident Physician, Department of Gynaecology and Obstetrics, Hannover Medical School, Hannover, Germany kramer.frauke@mh-hannover.de.
Frauke
F
Kramer
Cordula Schippert MD, Senior Physician, Department of Gynaecology and Obstetrics, Hannover Medical School.
Cordula
C
Schippert
Franziska Rinnau MD, Senior Physician, Department of Gynaecology and Obstetrics, Hannover Medical School.
Franziska
F
Rinnau
Peter Hillemanns MD, Professor, Head of Department, Department of Gynaecology and Obstetrics, Hannover Medical School.
Peter
P
Hillemanns
Tjoung-Won Park-Simon MD, Professor, Assistant Medical Director, Department of Gynaecology and Obstetrics, Hannover Medical School.
Tjoung-Won
TW
Park-Simon
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D016190:Carboplatin / Q000008:administration & dosage; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D000077143:Docetaxel; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced*; D005119:Extravasation of Diagnostic and Therapeutic Materials; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D012008:Recurrence; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects*
D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin