[Physiologic effects of hypothermia].
Therapeutic use of hypothermia has come to the frontline in the past decade again in the prevention and in mitigation of neurologic impairment. The application of hypothermia is considered as a successful therapeutic measure not just in neuro- or cardiac surgery, but also in states causing brain injury or damage. According to our present knowledge this is the only proven therapeutic tool, which improves the neurologic outcome after cardiac arrest, decreasing the oxygen demand of the brain. Besides influencing the nervous system, hypothermia influences the function of the whole organ system. Beside its beneficial effects, it has many side-effects, which may be harmful to the patient. Before using it for a therapeutic purpose, it is very important to be familiar with the physiology and complications of hypothermia, to know, how to prevent and treat its side-effects. The purpose of this article is to summarize the physiologic and pathophysiologic effects of hypothermia.
Semmelweis Egyetem, Általános Orvostudományi Kar Kardiológiai Központ, Kardiológiai Tanszék Budapest Városmajor u. 68. 1122.
Eniko
E
Kovács
Zsigmond
Z
Jenei
Anikó
A
Horváth
László
L
Gellér
Szabolcs
S
Szilágyi
Akos
A
Király
Levente
L
Molnár
Péter
P
Sótonyi
Béla
B
Merkely
Endre
E
Zima
D000818:Animals; D001833:Body Temperature Regulation; D001921:Brain / Q000378:metabolism / Q000502:physiology / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D002320:Cardiovascular Physiological Phenomena; D003422:Critical Care / Q000379:methods* / Q000592:standards; D004068:Digestive System Physiological Phenomena; D004562:Electrocardiography; D006323:Heart Arrest / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D006706:Homeostasis; D006801:Humans; D007035:Hypothermia / Q000503:physiopathology*; D007036:Hypothermia, Induced / Q000009:adverse effects; D009424:Nervous System Physiological Phenomena; D010101:Oxygen Consumption; D012143:Respiratory Physiological Phenomena; D014882:Water-Electrolyte Balance