PET imaging of nobiletin based on a practical total synthesis.
A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of (11)C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease.
School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Tomohiro
T
Asakawa
Aiki
A
Hiza
Miho
M
Nakayama
Makoto
M
Inai
Dai
D
Oyama
Hiroyuki
H
Koide
Kosuke
K
Shimizu
Toshiyuki
T
Wakimoto
Norihiro
N
Harada
Hideo
H
Tsukada
Naoto
N
Oku
Toshiyuki
T
Kan
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002250:Carbon Radioisotopes; D047309:Flavones / Q000138:chemical synthesis* / Q000378:metabolism; D008297:Male; D008745:Methylation; D049268:Positron-Emission Tomography / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002250:Carbon Radioisotopes; D047309:Flavones; C008661:nobiletin