Leukemia cutis in association With Grover's disease.
Grover's disease (GD), or transient acantholytic dermatosis, is a persistent recurrent dermatosis that usually occurs in men older than 50 years. Rare cases of GD and hematologic malignancy in the same cutaneous biopsy specimen have been reported. We report a case of GD in association with leukemia cutis. A 72-year-old man with a history of myelodysplastic syndrome presented with numerous pruritic papules on the torso, which were clinically diagnosed as GD. A skin biopsy revealed foci of suprabasal acantholysis and dyskeratosis consistent with GD and dense aggregates of mononuclear atypical cells in the superficial dermis consistent with leukemia cutis. Direct immunofluorescence was negative. This case illustrates the need to consider a diagnostic skin biopsy in any patient who presents with classic clinical findings of GD if there is any indication that the patient may be at higher risk for a hematologic malignancy.
Department of Medicine, Akron General Medical Center, Internal Medicine, Akron, OH 44307, USA. baldabagh@agmc.org
Bishr
B
Aldabagh
Rishi R
RR
Patel
Kord
K
Honda
D000051:Acantholysis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D020405:Dermis / Q000473:pathology; D017809:Fatal Outcome; D005419:Flavonoids / Q000627:therapeutic use; D006801:Humans; D006877:Hydroxamic Acids / Q000627:therapeutic use; D007057:Ichthyosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D007938:Leukemia / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D017254:Leukemic Infiltration / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000473:pathology; D010880:Piperidines / Q000627:therapeutic use; D016879:Salvage Therapy; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D000077337:Vorinostat
D000970:Antineoplastic Agents; D005419:Flavonoids; D006877:Hydroxamic Acids; D010880:Piperidines; C077990:alvocidib; D000077337:Vorinostat