Genetics in ocular inflammation--basic principles.
The ability to identify individuals at risk of ocular disease, or to determine the potential severity of disease or response to therapy is the current focus of much research. These studies are being led by genetic analysis of individuals to determine associations with alterations in gens that may explain manifestations of particular diseases. In this review we consider the basic principles behind genetic studies in general and of ocular disease in particular. We address the methodologies being utilised, and the results derived so far. The potential and pitfalls of such studies are relevant to the concept of personalised medicine and better defined clinical trials.
Academic Unit of Ophthalmology, School of Immunity and Infection, University of Birmingham, Birmingham, UK. g.r.wallace@bham.ac.uk
G R
GR
Wallace
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E
Niemczyk
D001528:Behcet Syndrome / Q000235:genetics; D005128:Eye Diseases / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods
D006680:HLA Antigens