Colchicine modulates oxidative stress in serum and leucocytes from remission patients with Family Mediterranean Fever through regulation of Ca²+ release and the antioxidant system.
We investigated the effects of colchicine on oxidative stress and Ca²+ release in serum and polymorphonuclear leucocytes (PMNs) of Familial Mediterranean Fever (FMF) patients with attack, remission and unremission periods. Eighteen FMF patients and six age-matched healthy subjects in four groups were used. The first group was a control. The second group included patients with active FMF. The third and fourth groups were patients with remission and unremission, respectively. Colchicine (1.5 mg/day) was given to the third and fourth groups for 1 month. PMN cells, serum lipid peroxidation and intracellular Ca²+-release levels in the attack and unremission groups were higher than in those in controls, although they were lower in the remission group than in the attack group. Serum vitamin E and β-carotene concentrations were higher in the remission group than in the control and attack groups. However, PMN, serum lipid peroxidation and Ca²+-release levels were further increased in the unremission group compared to the attack group. Glutathione peroxidase, reduced glutathione and vitamin A values in the four groups did not change by FMF and colchicine. In conclusion, we observed that colchicine induced protective effects on oxidative stress by modulating vitamin E, β-carotene and Ca²+-release levels in FMF patients with a remission period.
Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Mehmet
M
Sahin
A Cihangir
AC
Uğuz
Halil
H
Demirkan
Mustafa
M
Nazıroğlu
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D016022:Case-Control Studies; D003078:Colchicine / Q000008:administration & dosage* / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006074:Gout Suppressants / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D017136:Ion Transport / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D012074:Remission Induction; D044967:Serum / Q000737:chemistry; D014810:Vitamin E / Q000378:metabolism; D019207:beta Carotene / Q000378:metabolism
D000975:Antioxidants; D006074:Gout Suppressants; D019207:beta Carotene; D014810:Vitamin E; D009240:N-Formylmethionine Leucyl-Phenylalanine; D005979:Glutathione Peroxidase; D003078:Colchicine; D002118:Calcium
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