Impaired Set-Shifting Ability in Patients with Eating Disorders, Which Is Not Moderated by Their Catechol-O-Methyltransferase Val158Met Genotype.
The aim of this study was to examine the set-shifting ability in women with both anorexia nervosa (AN) and bulimia nervosa (BN) and to investigate whether it is contributed by the catechol-O-methyltransferase (COMT) Val158Met genotype. A total of 102 Korean participants-40 women with lifetime AN, 28 women with lifetime BN, and 34 healthy women of comparable age and intelligence quotient- were examined. A neuropsychological battery of tests was applied and blood samples were obtained for COMT Val158Met genotyping. Set-shifting impairments Trail Making Test (TMT, Part B) were found in patients with AN and BN, respectively. Furthermore, the eating disorders were also linked to deficits in attentional mechanisms (TMT, Part A) and motor skills (Finger Tapping Test). Finally, set-shifting and its link to eating disorders were not moderated by COMT Val158Met genotype.
Department of Neuropsychiatry, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Youl-Ri
YR
Kim
Ji Eun
JE
Kim
Mi Hyun
MH
Kim
J Int Neuropsychol Soc. 2004 Jul;10(4):513-20
15327730
Int J Eat Disord. 1994 Dec;16(4):363-70
7866415
Schizophr Bull. 2006 Jan;32(1):179-94
16166612
Am J Psychiatry. 2005 Oct;162(10):1980-2
16199852
Can J Psychiatry. 2007 Apr;52(4):212-9
17500301
Int J Eat Disord. 2007 Nov;40(7):613-21
17607697
Int J Eat Disord. 2007 Nov;40 Suppl:S52-60
17573683
J Psychiatry Neurosci. 2005 Sep;30(5):335-9
16151538
Am J Psychiatry. 2005 Dec;162(12):2269-75
16330590
Mol Psychiatry. 2007 May;12(5):502-9
17325717
Am J Psychiatry. 2000 Mar;157(3):393-401
10698815
Psychol Med. 2007 Aug;37(8):1075-84
17261218
Biol Psychiatry. 2000 May 1;47(9):794-803
10812038
Bipolar Disord. 2004 Jun;6(3):171-82
15117396