Efficacy of clobetasol spray: factors beyond patient compliance.
Clobetasol 0.05% spray, a topical clobetasol propionate, is a non-greasy formulation that has shown increased clinical efficacy in a head-to-head comparison with foam formulation. Moreover, available data from randomized, controlled, double-blind trials suggests that clobetasol spray is, in fact, slightly more effective than most, if not all, other preparations of clobetasol. The fact that clobetasol spray is exceptionally easy to comply with may have played a major role in this outcome; however, other factors must be considered. These include vehicle metamorphosis post-application as well as vehicle and excipient effects on stratum corneum permeability. Basic concepts in topical drug delivery and how they apply to this spray vehicle may further explain the greater efficacy of clobetasol spray.
University of California, Department of Dermatology, San Francisco, San Francisco, CA, USA. tinabhutanimd@gmail.com
Tina
T
Bhutani
John
J
Koo
Howard I
HI
Maibach
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D002990:Clobetasol / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D055118:Medication Adherence; D014677:Pharmaceutical Vehicles; D011565:Psoriasis / Q000188:drug therapy* / Q000378:metabolism; D012869:Skin Absorption
D000893:Anti-Inflammatory Agents; D014677:Pharmaceutical Vehicles; D002990:Clobetasol