Significance of Elevated Blood Metal Ion Levels in Patients with Metal-on-Metal Prostheses: An Evaluation of Oxidative Stress Markers.
It is widely known that cobalt and chromium ions can enhance the production of reactive oxygen species, known to be damaging to cells by disturbing their redox status and then generating oxidative stress. The aim of the present study was to determine if increased metal ion levels induce a state of oxidative stress in patients with metal-on-metal (MM) hip arthroplasty. Results indicated that there was no significant difference in the concentration of oxidative stress markers (total antioxidants, peroxides, and nitrated proteins) in the patients with MM bearings compared to patients without prostheses. The activity antioxidant enzymes was stable (catalase and glutathione peroxidase) or slightly decreased (superoxide dismutase and heme oxygenase-1) over time. This work is the first to determine the biological effects of metal ions released from MM hip implants with regards to mid-term systemic oxidative stress and showed that the increased levels of Co and Cr ions are not associated with significant oxidative stress damage in the plasma of patients with these implants.
Department of Biomedical Engineering, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.
Cathy
C
Tkaczyk
Alain
A
Petit
John
J
Antoniou
David J
DJ
Zukor
Maryam
M
Tabrizian
Olga L
OL
Huk
Clin Biochem. 2008 May;41(7-8):538-43
18313405
Front Biosci. 1999 Mar 15;4:D339-45
10077544
J Bone Joint Surg Am. 2000 Apr;82(4):457-76
10761937
Food Chem Toxicol. 1999 Sep-Oct;37(9-10):949-62
10541450
Cancer Res. 1991 Feb 1;51(3):974-8
1988141
J Bone Joint Surg Am. 2008 Aug;90 Suppl 3:142-8
18676949
Rev Chir Orthop Reparatrice Appar Mot. 2004 May;90(3):241-8
15211273
J Bone Joint Surg Br. 2006 Apr;88(4):443-8
16567776
J Biomed Mater Res. 1999 Dec 15;47(4):543-50
10497290
J Biol Chem. 2006 Mar 17;281(11):6904-9
16377630
J Ocul Pharmacol Ther. 2000 Apr;16(2):193-201
10803430
Clin Biochem. 1999 Nov;32(8):595-603
10638941
J Bone Joint Surg Br. 2003 Aug;85(6):913-7
12931818
Clin Orthop Relat Res. 1996 Aug;(329 Suppl):S280-9
8769342
Proc Inst Mech Eng H. 2006 Feb;220(2):399-407
16669405
Br J Dermatol. 2003 Jun;148(6):1089-93
12828734
J Pineal Res. 2004 Jan;36(1):1-9
14675124
J Environ Pathol Toxicol Oncol. 2001;20(2):77-88
11394715
J Biomed Mater Res. 2002;63(5):467-74
12209889
J Bone Joint Surg Br. 2000 Jul;82(5):748-54
10963179
J Bone Joint Surg Br. 1975 Nov;57(4):444-50
1194310
J Infect Dis. 2004 Sep 15;190(6):1109-18
15319861
Proc Inst Mech Eng H. 2006 Feb;220(2):379-84
16669403
Clin Orthop Relat Res. 1996 Aug;(329 Suppl):S233-43
8769337
Joint Bone Spine. 2007 Jul;74(4):324-9
17590367
Free Radic Res. 2008 Nov;42(11-12):949-56
19031313
Free Radic Res. 1999 Dec;31(6):459-75
10630670
J Bone Joint Surg Am. 2001 Mar;83(3):428-36
11263649
J Bone Joint Surg Br. 2003 Jul;85(5):758-64
12892206
J Bone Joint Surg Am. 1993 Jun;75(6):825-34
8314823
J Bone Joint Surg Br. 2001 Sep;83(7):1075-81
11603526
J Bone Joint Surg Am. 2001 May;83(5):774-80
11379749
Proc Inst Mech Eng H. 2006 Feb;220(2):385-98
16669404
J Biomed Mater Res A. 2003 Sep 1;66(3):450-6
12918026
Biochim Biophys Acta. 2004 Nov 1;1674(3):251-9
15541294
J Bone Joint Surg Br. 2001 Nov;83(8):1093-5
11764417
Biomaterials. 2006 Jun;27(18):3351-60
16488005
J Mater Sci Mater Med. 2007 May;18(5):725-51
17143737
Clin Orthop Relat Res. 2003 Jan;(406):282-96
12579029
Free Radic Biol Med. 1995 Feb;18(2):321-36
7744317
Toxicol Sci. 2008 Jun;103(2):325-34
18332044
J Bone Joint Surg Br. 1994 Sep;76(5):701-12
8083255
J Orthop Res. 2003 Mar;21(2):189-95
12568948
Homeopathy. 2008 Oct;97(4):185-9
19371566
J Arthroplasty. 2004 Dec;19(8 Suppl 3):71-7
15578557
J Bone Joint Surg Am. 2003 Nov;85(11):2168-73
14630848