Redox signaling and cardiac sarcomeres.
Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis. There is growing evidence that the cardiodepressant actions of reactive oxygen species (ROS) also are attributable to ROS-dependent signaling events in the sarcomere. This minireview focuses on myofilament protein post-translational modifications induced by ROS or ROS-activated signaling enzymes that regulate cardiac contractility.
Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, Kentucky 40536, USA. mariussumandea@uky.edu
Marius P
MP
Sumandea
Susan F
SF
Steinberg
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006331:Heart Diseases / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D012518:Sarcomeres / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D002118:Calcium
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