Zinc homeostasis is involved in unfolded protein response under salt stress.
Accumulation of unfolded protein or misfolded protein causes endoplasmic reticulum (ER) stress. Increased salt concentration activates a stress response pathway in the ER in Arabidopsis thaliana to induce the expression of several salt stress response genes, leading to a more optimal protein folding environment in the ER. In addition, some salt stress-regulated proteins require zinc for their activity, including some zinc-dependent DNA binding proteins and zinc-finger proteins. In a recent study, we reported that ZTP29, a putative zinc transporter at the ER membrane, is involved in the response to salt stress through regulation of zinc level in the ER to induce the UPR pathway. In this addendum, we propose a testable hypothesis for the role of ZTP29 in the response to salt stress via the regulation of zinc levels in the ER.
State Key Laboratory of Plant Physiology and Biochemistry, Department of Plant Sciences, College of Biological Sciences, China Agricultural University, Beijing, China.
Miaoying
M
Wang
Qiangyi
Q
Xu
Ming
M
Yuan
D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D008954:Models, Biological; D030821:Plants, Genetically Modified; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012965:Sodium Chloride / Q000494:pharmacology*; D013312:Stress, Physiological / Q000187:drug effects / Q000235:genetics; D056811:Unfolded Protein Response / Q000187:drug effects; D015032:Zinc / Q000378:metabolism*
D029681:Arabidopsis Proteins; D012333:RNA, Messenger; D012965:Sodium Chloride; D015032:Zinc
J Cell Sci. 2002 Jun 1;115(Pt 11):2443-52
12006628
Plant Cell Physiol. 2002 May;43(5):532-9
12040100
Plant Cell. 2002;14 Suppl:S165-83
12045276
J Cell Biol. 2004 Aug 2;166(3):325-35
15277543
Plant Cell. 2003 Oct;15(10):2273-84
12972670
Curr Opin Cell Biol. 2001 Aug;13(4):399-404
11454443
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5280-5
15781873
Plant Cell. 2007 Dec;19(12):4111-9
18156219
Plant Mol Biol. 2010 Jul;73(4-5):467-79
20358261
Nature. 1992 Jan 2;355(6355):33-45
1731198
Plant J. 2007 Sep;51(5):897-909
17662035