Translating experimental neuroscience into treatment of eating disorders: two examples.
Anorexia nervosa (AN) is a serious mental disorder with impaired functioning including not only the cognitive and socio-emotional but also physical domains. Improved treatments, especially for adults with AN, are urgently needed. The insights gained from basic research in experimental animal models and the advent of cognitive neuroscience have produced major advances in our understanding of the condition, but translating these into clinical research or practice remains a challenge. We describe here what the eating disorders field can gain from schizophrenia research in this area. We use the example of socio-emotional impairments in AN to describe the iterative process between basic research and intervention development for neurobiologically informed and based treatments for this condition and briefly touch on some other examples that stem from translational science.
Section of Eating Disorders, King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. u.schmidt@iop.kcl.ac.uk
Ulrike
U
Schmidt
Anna
A
Oldershaw
Annemarie
A
van Elburg
D000818:Animals; D000856:Anorexia Nervosa / Q000150:complications* / Q000628:therapy*; D003072:Cognition Disorders / Q000209:etiology / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D019964:Mood Disorders / Q000209:etiology / Q000628:therapy; D009488:Neurosciences; D012919:Social Behavior; D057170:Translational Research, Biomedical