Thromboxane-A(2)/prostaglandin-H(2) receptors Characterization and antagonism.
Thromboxane A(2) (TXA(2)) is a potent vasoconstrictor and platelet aggregator whose synthesis is increased in a variety of cardiovascular diseases. TXA(2) receptor antagonists have been used to (a) establish a pathophysiologic role for TXA(2) in a variety of cardiovascular diseases, (b) subtype platelet and vascular receptors, (c) elucidate structural characteristics of the receptor, and (d) aid in its purification. However, much still remains to be learned about the structure and function of TXA(2) receptors.
Departments of Pharmacology and Medicine, Division of Clinical Pharmacology, Medical University of South Carolina, Charleston, SC 29425, USA.
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Morinelli
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Halushka