Stevens rearrangement as a tool for the structural modification of polyaminopolycarboxylic ligands.
Polyaminopolycarboxylic acids are a well known class of ligands employed for metal ion complexation. Despite the large commercial availability, reports of their use as substrates for direct structural modifications are rare. Herein we report a simple and efficient protocol for the preparation of substituted polyaminopolycarboxylic ligands relying on a one-pot N-alkylation-Stevens rearrangement cascade.
DiSCAFF & DFB Center, Via Bovio 6, I-28100, Novara, Italy. giovenzana@pharm.unipmn.it
Giovanni B
GB
Giovenzana
Daniela
D
Imperio
Luciano
L
Lattuada
Fulvio
F
Uggeri
D000478:Alkylation; D002264:Carboxylic Acids / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D011073:Polyamines / Q000737:chemistry*
D002264:Carboxylic Acids; D008024:Ligands; D011073:Polyamines