Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire.
The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.
Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.
Christoph R
CR
Arnold
Juliane
J
Wolf
Stefan
S
Brunner
Dietmar
D
Herndler-Brandstetter
Beatrix
B
Grubeck-Loebenstein
D000375:Aging / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D056747:Immunomodulation; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
D000941:Antigens
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