Shen-fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest.
To investigate the effect of Shen-Fu injection (SFI) for the management of postresuscitation myocardial dysfunction in a porcine model of cardiac arrest. Ventricular fibrillation was induced electrically in anesthetized domestic swine. After 4 min of untreated ventricular fibrillation, cardiopulmonary resuscitation was initiated. Sixteen successfully resuscitated pigs were randomized to receive a continuous infusion of either SFI (0.24 mg/min) or saline placebo for 6 h, beginning 15 min after return of spontaneous circulation (ROSC). The SFI treatment produced better left ventricular +dP/dtmax, -dP/dtmax, cardiac output, and ejection fraction after ROSC. The SFI treatment also produced lower serum cardiac troponin I, lactate levels, and left ventricle malondialdehyde content after ROSC, whereas left ventricle superoxide dismutase, Na-K-ATPase, and Ca-ATPase activity were significantly increased in the SFI group when compared with saline group. The cardioprotective effect of SFI was further confirmed by myocardial ultrastructure examination. Shen-Fu injection can attenuate postresuscitation myocardial dysfunction through beneficial effects on energy metabolism and remarkable antioxidant capacity.
Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xian-Fei
XF
Ji
Lin
L
Yang
Ming-Yue
MY
Zhang
Chun-Sheng
CS
Li
Shuo
S
Wang
Lu-Hong
LH
Cong
D000818:Animals; D016887:Cardiopulmonary Resuscitation; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects; D006323:Heart Arrest / Q000188:drug therapy*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D013552:Swine
D004365:Drugs, Chinese Herbal; C492793:Shen-Fu