Natural coagulation inhibitors and active protein c resistance in preeclampsia.
BACKGROUND
The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia.


OBJECTIVE
The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R) in preeclampsia.


METHODS
We studied 70 women with preeclampsia recruited consecutively and 70 healthy pregnant and 70 nonpregnant women as controls. Plasma protein C (PC), free protein S (fPS), antithrombin III (ATIII) and APC-R were evaluated.


RESULTS
ATIII values were found to be significantly lower in preeclamptic patients than in the control groups (p< 0.001). Nevertheless, there was no significant difference between the healthy pregnant and nonpregnant women groups (p=0.141). The fPS values of the preeclamptic and healthy pregnant groups were lower than that of the nonpregnant group (p< 0.001), and the fPS value of the preeclamptic pregnant women was lower than that of healthy pregnant women (p<0.001). The PC value of the preeclamptic pregnant women was lower than that of the control groups (p< 0.001). The PC value of the healthy pregnant women was lower than that of the nonpregnant women (p< 0.001). The mean APC activity values were lower in the preeclamptic patients than that of the control groups (p< 0.001, p< 0.001). The APC-R positivity rates of the preeclamptic groups were higher than that of the control groups (p<0.001).


CONCLUSIONS
This study demonstrated that ATIII, fPS, PC values and APC resistance were lower and APC-R positivity was higher in preeclamptic women than in normal pregnant and nonpregnant women.
Department of Hematology, Medical Faculty, Yuzuncu Yil University, Turkey. drcengizdemir@hotmail.com
Cengiz
C
Demir
Imdat
I
Dilek
D000328:Adult; D000704:Analysis of Variance; D000990:Antithrombin III / Q000032:analysis*; D001777:Blood Coagulation; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D017293:Protein S / Q000032:analysis*; D018455:Protein S Deficiency / Q000097:blood; D012307:Risk Factors; D055815:Young Adult
D017293:Protein S; D000990:Antithrombin III; D002097:C-Reactive Protein
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