Highly sensitive detection of saccharides under physiological conditions with click synthesized boronic acid-oligomer fluorophores.
Two phenylboronic acid based saccharide sensors bearing conjugated oligomer fluorophores with linear and cruciform π-frameworks were synthesized in a modular approach utilizing a Cu-catalyzed alkyne azide cycloaddition (click) reaction. The cruciform fluorophore showed excellent saccharide sensing function under physiological conditions in the mM range, whereas the linear fluorophore gave very limited sensing functions. The different fluorescent sensing behaviours highlight the important role of oligomer fluorophore in the development of effective saccharide sensors.
Department of Chemistry, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3X7.
Karimulla
K
Mulla
Prateek
P
Dongare
Ningzhang
N
Zhou
Guang
G
Chen
David W
DW
Thompson
Yuming
Y
Zhao
D001897:Boronic Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D015394:Molecular Structure
D001897:Boronic Acids; D002241:Carbohydrates; D005456:Fluorescent Dyes