Mechanisms of hyperglycemic effect of calcitonin.
We studied the effect of calcitonin on blood glucose level, total calcium content, and the main stages of carbohydrate metabolism: absorption in the intestine, transport from the blood to tissues, tissue sensitivity to insulin in the whole organism, glycogen content, and activity of glucose-6-phosphate dehydrogenase and lactate dehydrogenase in the liver. A hyperglycemic effect of calcitonin was demonstrated, a close negative correlation was found between glucose level and total calcium content (r=-0.834, p<0.02). Calcitonin had no effect on glucose absorption in the small intestine and its transport from the blood to tissues (glucose consumption by peripheral tissues at the organism level), but reduced glycogen content in the liver and increased activities of glucose-6-phosphate dehydrogenase and lactate dehydrogenase.
Department of General Physiology, St. Petersburg State University, Russia. butalana07@list.ru
S S
SS
Butakova
A D
AD
Nozdrachev
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D051381:Rats
D001786:Blood Glucose; D006003:Glycogen; D002116:Calcitonin; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D002118:Calcium