Potent engineered PLGA nanoparticles by virtue of exceptionally high chemotherapeutic loadings.
Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT (particle replication in nonwetting templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere.
Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Elizabeth M
EM
Enlow
J Christopher
JC
Luft
Mary E
ME
Napier
Joseph M
JM
DeSimone
D000042:Absorption; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D003460:Crystallization / Q000379:methods*; D004058:Diffusion; D000077143:Docetaxel; D004339:Drug Compounding / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D043823:Taxoids / Q000008:administration & dosage* / Q000737:chemistry*
D000970:Antineoplastic Agents; D053769:Nanocapsules; D043823:Taxoids; D000077143:Docetaxel; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid
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