Neural and behavioral effects of interference resolution in depression and rumination.
Individuals diagnosed with major depressive disorder (MDD) often ruminate about their depression and their life situations, impairing their concentration and performance on daily tasks. We examined whether rumination might be due to a deficit in the ability to expel negative information from short-term memory (STM), and fMRI was used to examine the neural structures involved in this ability. MDD and healthy control (HC) participants were tested using a directed-forgetting procedure in a short-term item recognition task. As predicted, MDD participants had more difficulty than did HCs in expelling negative, but not positive, words from STM. Overall, the neural networks involved in directed forgetting were similar for both groups, but the MDDs exhibited more spatial variability in activation in the left inferior frontal gyrus (a region critical for inhibiting irrelevant information), which may contribute to their relative inability to inhibit negative information.
Department of Psychology, University of Michigan, Ann Arbor, MI 48109-1043, USA. bermanm@umich.edu
Marc G
MG
Berman
Derek Evan
DE
Nee
Melynda
M
Casement
Hyang Sook
HS
Kim
Patricia
P
Deldin
Ethan
E
Kross
Richard
R
Gonzalez
Emre
E
Demiralp
Ian H
IH
Gotlib
Paul
P
Hamilton
Jutta
J
Joormann
Christian
C
Waugh
John
J
Jonides
D000293:Adolescent; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D003863:Depression / Q000473:pathology / Q000503:physiopathology*; D019959:Feeding and Eating Disorders of Childhood / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology*; D055815:Young Adult
D010100:Oxygen
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