Genetic modifiers of neurological disease.
Genetic modifiers make an important contribution to neurological disease phenotypes. Significant progress has been made by studying genetic modifiers in model organisms. The ability to study complex genetic interactions in model systems contributes to our understanding of the genetic factors that influence neurological disease. This will lead to the development of novel therapeutic strategies and personalized treatment based on genetic risk.
Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, 529 Light Hall, 2215 Garland Ave, Nashville, TN 37232-0275, USA. jennifer.kearney@vanderbilt.edu
Jennifer A
JA
Kearney
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006816:Huntington Disease / Q000235:genetics; D051379:Mice; D009422:Nervous System Diseases / Q000235:genetics*; D010641:Phenotype; D000072260:RNA Splicing Factors; D015518:Rett Syndrome / Q000235:genetics; D020754:Spinocerebellar Ataxias / Q000235:genetics
D002352:Carrier Proteins; D000072260:RNA Splicing Factors; C476996:Scnm1 protein, mouse
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