Remission of membranous glomerulonephritis after pancreatectomy for pancreatic neuroendocrine neoplasm - a rare coincidence.
The concomitant existence of a non-malignant neuroendocrine tumor (NET) and membranous glomerulonephritis (MGN) is rare. We report a subject with kidney biopsy proven MGN and nephrotic syndrome in which a computerized scan tomography (CT) examination was performed revealing a pancreatic tumor. A pancreatectomy was performed and the tumor was shown to be a non-malignant NET with a malignant potential. Although treatment with corticosteroids was initiated remission of MGN was observed within the next month after pancreatectomy. The rapid remission observed shortly after pancreatectomy pointed to that tumor removal contributed to, and that neither spontaneous nor corticosteroid treatment alone did induce the rapid remission of the MGN. The coexistence of the two disorders NET and MGN is very rare, however. This is the first report on remission of MGN after pancreatectomy for a NET.
Division of Nephrology, Department of Internal Medicine, Central Finland Health Care District Hospital, Jyväskylä, Finland. terje.forslund@ksshp.fi
T
T
Forslund
I
I
Kellokumpu
E
E
Elomaa
J
J
Arola
K
K
Nuorva
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology; D018358:Neuroendocrine Tumors / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D012074:Remission Induction; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones