Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab.
A 65-year-old woman who had suffered from chronic graft-versus-host disease (GVHD) presented with extensive purpura and was diagnosed with acquired hemophilia A. Because she was refractory to corticosteroids and her condition was complicated with diabetes mellitus, glaucoma, and hypoglobulinemia, she was treated with tocilizumab. Tocilizumab treatment increased the activity of factor VIII in a rapid and sustained manner, leading to a reduction of the prednisolone dose. Tocilizumab may thus be an optional treatment modality for acquired hemophilia A.
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Sumiyuki
S
Nishida
Tomio
T
Kawasaki
Hirokazu
H
Kashiwagi
Atsuyoshi
A
Morishima
Yoshihiro
Y
Hishitani
Mari
M
Kawai
Toru
T
Hirano
Taeko
T
Ishii
Keisuke
K
Hagihara
Yoshihito
Y
Shima
Masashi
M
Narazaki
Atsushi
A
Ogata
Yoshihiro
Y
Oka
Tadamitsu
T
Kishimoto
Toshio
T
Tanaka
D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000150:complications / Q000188:drug therapy*; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D061067:Antibodies, Monoclonal, Humanized; D005938:Glucocorticoids; D005169:Factor VIII; D011239:Prednisolone; C502936:tocilizumab