UV-prepared salep-based nanoporous hydrogel for controlled release of tetracycline hydrochloride in colon.
A highly swelling nanoporous hydrogel (NPH) was synthesized via UV-irradiation graft copolymerization of acrylic acid (AA) onto salep backbone and its application as a carrier matrix for colonic delivery of tetracycline hydrochloride (TH) was investigated. Optimized synthesis of the hydrogel was performed by the classic method. The swelling behavior of optimum hydrogel was measured in different media. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FTIR) and thermo-gravimetric analysis (TGA/DTG/DTA). The study of the surface morphology of hydrogels using SEM showed a nanoporous (average pore size: about 350nm) structure for the sample obtained under optimized conditions. The drug delivery results demonstrated that this NPH could successfully deliver a drug to the colon without losing the drug in the stomach, and could be a good candidate as an orally administrated drug delivery system.
Department of Chemistry, Payame Noor University, Qazvin Branch, P.O. Box 878, Qazvin, Iran. rezanejad@pnu.ac.ir
Ghasem Rezanejade
GR
Bardajee
Ali
A
Pourjavadi
Somayeh
S
Ghavami
Rouhollah
R
Soleyman
Farnaz
F
Jafarpour
D000042:Absorption; D000179:Acrylates / Q000737:chemistry; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010936:Plant Extracts / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D013752:Tetracycline / Q000737:chemistry / Q000378:metabolism*; D013997:Time Factors; D014466:Ultraviolet Rays; D014867:Water / Q000737:chemistry
D000179:Acrylates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D010936:Plant Extracts; D014867:Water; D013752:Tetracycline; C036658:acrylic acid