Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb.
Odors are encoded in spatio-temporal patterns within the olfactory bulb, but the mechanisms of odor recognition and discrimination are poorly understood. It is reasonable to postulate that the olfactory code is sculpted by lateral and feedforward inhibition mediated by granule cells onto the mitral cells. Recent viral tracing and physiological studies revealed patterns of distributed granule cell synaptic clusters that provided additional clues to the possible mechanisms at the network level. The emerging properties and functional roles of these patterns, however, are unknown. Here, using a realistic model of 5 mitral and 100 granule cells we show how their synaptic network can dynamically self-organize and interact through an activity-dependent dendrodendritic mechanism. The results suggest that the patterns of distributed mitral-granule cell connectivity may represent the most recent history of odor inputs, and may contribute to the basic processes underlying mixture perception and odor qualities. The model predicts how and why the dynamical interactions between the active mitral cells through the granule cell synaptic clusters can account for a variety of puzzling behavioral results on odor mixtures and on the emergence of synthetic or analytic perception.
Institute of Biophysics, National Research Council Palermo, Italy.
Michele
M
Migliore
Michael L
ML
Hines
Thomas S
TS
McTavish
Gordon M
GM
Shepherd
Behav Neurosci. 2005 Jun;119(3):726-33
15998193
J Neurosci. 2001 Dec 15;21(24):9837-43
11739591
J Physiol Paris. 2007 Jan-May;101(1-3):40-5
18054211
Neurobiol Learn Mem. 2008 Jul;90(1):178-84
18406178
Behav Neurosci. 2003 Apr;117(2):236-45
12708520
Front Integr Neurosci. 2007 Dec 30;1:12
18958240
J Neurosci. 2010 Feb 3;30(5):1760-5
20130185
Science. 1997 Oct 17;278(5337):463-7
9334305
Nature. 2010 May 6;465(7294):47-52
20393466
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3371-5
7724568
Nat Neurosci. 2009 Jun;12(6):731-3
19412165
J Neurosci. 1982 Jan;2(1):32-48
7054394
J Neurosci. 2009 Oct 28;29(43):13454-64
19864558
J Comput Neurosci. 2004 Jan-Feb;16(1):39-47
14707543
Hippocampus. 1996;6(1):35-42
8878740
Neuron. 2000 Mar;25(3):625-33
10774730
Neuron. 1999 Jul;23(3):499-511
10433262
J Comp Neurol. 2007 Jul 1;503(1):1-34
17480025
J Neurophysiol. 2002 Nov;88(5):2755-64
12424310
Neuron. 2006 Feb 2;49(3):467-79
16446149
J Neurosci. 2003 May 15;23(10):4108-16
12764098
Eur J Neurosci. 2004 Mar;19(6):1668-72
15066163
Neuron. 2002 Mar 28;34(1):115-26
11931746
Chem Senses. 2008 Apr;33(4):363-9
18283044
Biol Rev Camb Philos Soc. 2007 Aug;82(3):455-79
17624963
Eur J Neurosci. 2008 May;27(10):2676-85
18445053
Percept Psychophys. 1994 Apr;55(4):363-72
8036116
PLoS Pathog. 2009 Oct;5(10):e1000640
19876391
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12592-7
16895993
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15206-11
17005727
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Feb;192(2):135-50
16328534
J Neurophysiol. 2009 May;101(5):2204-9
19261715
Eur J Neurosci. 2003 Nov;18(10):2690-6
14656317
Perception. 1990;19(1):123-32
2336328
J Comp Neurol. 1999 Jul 12;409(4):529-48
10376738
Nat Neurosci. 2002 Nov;5(11):1194-202
12379859
Physiol Behav. 1999 May;66(3):497-502
10357440
Neuron. 2008 Sep 11;59(5):802-14
18786363
Neurosci Biobehav Rev. 2003 Sep;27(4):307-28
12946684
J Comput Neurosci. 2008 Apr;24(2):207-21
17674173
J Neurosci. 2009 Sep 30;29(39):12302-14
19793989
J Neurosci. 2003 Jul 2;23(13):5553-60
12843256
Nat Neurosci. 2009 Jun;12(6):728-30
19412168
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17980-5
19815505
Nat Neurosci. 1999 Dec;2(12):1106-13
10570488
Neuroscience. 2000;95(2):325-32
10658611
Neural Comput. 1997 Aug 15;9(6):1179-209
9248061
J Neurophysiol. 2007 Jul;98(1):205-13
17460109
Nat Neurosci. 2009 Feb;12(2):210-20
19151709