Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells.
T cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor identified by differential mRNA display during thymocyte apoptosis induced by T cell receptor engagement. To examine the physiological role of an orphan G-protein-coupled receptor TDAG8 in inflammation, we studied various immune-mediated inflammatory disease models using TDAG8-deficient mice. We found that TDAG8-deficient mice showed significant exacerbation of anti-type II collagen antibody-induced arthritis and delayed-type hypersensitivity, and showed a slight exacerbation of collagen-induced arthritis. These results suggest that TDAG8 acts as a negative regulator of inflammation.
Biological Research Laboratories III, Daiichi Sankyo Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan.
Yoshiko
Y
Onozawa
Tomoaki
T
Komai
Tomiichiro
T
Oda
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism; D002417:Cattle; D024043:Collagen Type II / Q000276:immunology / Q000494:pharmacology; D055786:Gene Knockout Techniques; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008745:Methylation; D051379:Mice; D008810:Mice, Inbred C57BL; D043562:Receptors, G-Protein-Coupled / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D000906:Antibodies; D024043:Collagen Type II; C513337:GPR65 protein, mouse; D043562:Receptors, G-Protein-Coupled; D012710:Serum Albumin, Bovine