Comparison of the hypotensive and bradycardic activity of ginkgo, garlic, and onion extracts.
The acute effect of ethanol extracts ginkgo (Ginkgo biloba L.), garlic (Allium sativum L.), and onion (Allium cepa L.) on arterial blood pressure (BP), and heart rate (HR) in anesthetized normotensive rats was examined and compared. Arterial BP was registered in the left carotid artery. The data showed that intravenous administration of the extracts produced dose-dependent and reversible hypotensive and bradycardic effects. The most effective in reducing arterial BP and HR is extract of garlic. There were statistically significant differences in bradycardic and hypotensive effects of the garlic and ginkgo extracts.
Department of Physiology, Faculty of Medicine, University of Nis, Serbia.
Suzana
S
Brankovic
Mirjana
M
Radenkovic
Dusanka
D
Kitic
Slavimir
S
Veljkovic
Vesna
V
Ivetic
Dragana
D
Pavlovic
Bojana
B
Miladinovic
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001919:Bradycardia / Q000209:etiology; D005737:Garlic / Q000737:chemistry; D020441:Ginkgo biloba / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D019697:Onions / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D010936:Plant Extracts