Endo-selective enyne ring-closing metathesis promoted by stereogenic-at-W mono-pyrrolide complexes.
The utility of W-alkylidene complexes for enyne ring-closing metathesis is demonstrated in a direct comparison with Mo-based analogs. Tungsten complexes lead to less alkyne oligomerization and higher levels of endo-selectivity and enantioselectivity.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Yu
Y
Zhao
Amir H
AH
Hoveyda
Richard R
RR
Schrock
D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014414:Tungsten / Q000737:chemistry*
D000475:Alkenes; D000480:Alkynes; D009942:Organometallic Compounds; D011758:Pyrroles; D008982:Molybdenum; D014414:Tungsten
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