Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia.
We examined intensity and shape differences in 378 repeated spectroscopic measures of the cervix. We examined causes of variability such as presence of precancer or cancer, pathologic tissue type, menopausal status, hormone or oral contraceptive use, and age; as well as technology related variables like generation of device and provider making exam. Age, device generation, and provider were statistically significantly related to intensity differences. Provider and device generation were related to shape differences. We examined the order of measurements and found a decreased intensity in the second measurement due to hemoglobin absorption. 96% of repeat measurements had classification concordance of cervical intraepithelial neoplasia.
José-Miguel
JM
Yamal
Dennis D
DD
Cox
E Neely
EN
Atkinson
Calum
C
Macaulay
Roderick
R
Price
Michele
M
Follen
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