Total synthesis of (-)-brevisin: a concise synthesis of a new marine polycyclic ether.
The first and highly efficient total synthesis of (-)-brevisin has been achieved. The title compound was synthesized in only 29 steps (longest linear sequence) from commercially available starting materials. The synthesis provided over 70 mg of a marine polycyclic ether compound.
Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Takefumi
T
Kuranaga
Naohito
N
Ohtani
Ryosuke
R
Tsutsumi
Daniel G
DG
Baden
Jeffrey L C
JL
Wright
Masayuki
M
Satake
Kazuo
K
Tachibana
D004141:Dinoflagellida / Q000737:chemistry; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D004988:Ethers, Cyclic; D011083:Polycyclic Compounds; C550958:brevisin
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