The changes in submandibular gland size and function following chorda tympani section.
To investigate the effects of chorda tympani section on submandibular gland size and function in the early (postoperative day 7) and late (postoperative month 6) postoperative period by ultrasonography, scintigraphy, and biochemical analysis of the saliva patients with unilateral chronic otitis media. One-hundred and thirty patients (46 males and 84 females) who were ≥16 years of age and diagnosed with unilateral chronic otitis media and for whom type 1 tympanoplasty was indicated in 1st Outpatient Clinic of Kartal Dr. Lutfi Kirdar Training and Research Hospital between August 2004 and February 2007 were enrolled in the study. Of 130 patients, 102 patients who were eligible and gave written approval were included in the study. However, of these patients 99 underwent type 1 tympanoplasty and 3 had a canal down mastoidectomy. In 99 patients, chorda tympani nerves of 16 were cut, but 3 patients had to be excluded due to allergic reactions. Before the operation, bilateral submandibular gland ultrasonography was performed on all patients and the anterior-posterior length, the frontal lateral-medial width (transverse), and the paramandibular depth of both submandibular glands were measured. In scintigraphic examinations, perfusion index (PI), uptake ratio and excretion fraction were measured. Then, in biochemical analysis of the saliva the levels of sodium, potassium, chloride, calcium, magnesium, amylase, and the values of pH and density were assessed by the saliva collection through Wharton duct. In the statistical comparison of operated and healthy side of the patients with respect to these parameters Mann-Whitney U test, and in intragroup analysis Wilcoxon test was used. The volume of the submandibular gland of the operated side was significantly lower compared to the healthy side in postoperative month 6 (P < 0.05). According to the baseline volume of the submandibular gland of the healthy side, the increase in postoperative day 7 and month 6 were found to be statistically insignificant (P > 0.05). According to the baseline PI value, the decreases in the PI value in the postoperative day 7 and postoperative month 6 were statistically significant (P < 0.01). The uptake ratio of the patients was lower in the postoperative day 7 and month 6 than those at the baseline; however, the difference was statistically insignificant (P > 0.05). The excretion fraction values in the postoperative day 7 were significantly lower than the baseline values (P < 0.05), whereas the decrease in the EF values in the postoperative month 6 were statistically insignificant (P > 0.05). In conclusion, the present study was the first in the literature in which three parameters of assessment, such as ultrasonography, scintigraphy, and biochemical analysis, were used to determine the changes in submandibular gland size and function following the chorda tympani section. After chorda tympani section, the volume of submandibular gland decreased in the late postoperative period. Moreover, chorda tympani section led to decrease in the saliva secretion and the PI value of the patients in the early and late postoperative period.
Department of Otolaryngology, Head and Neck Surgery, Derince Training and Research Hospital, Kocaeli, Turkey.
Birgül
B
Uzun
Department of Otolaryngology, Head and Neck Surgery, Tekden Medical Center, Kayseri, Turkey. dramahmut@yahoo.com.|, Kosk Mah. Incirli Sok. No. 36 Muhendisler Sitesi D Blok D: 16, Melikgazi, Kayseri, Turkey. dramahmut@yahoo.com.
Mahmut
M
Özkiriş
Department of Otolaryngology, Head and Neck Surgery, Kartal Training and Research Hospital, Istanbul, Turkey.
Utku
U
Kubilay
D000293:Adolescent; D000328:Adult; D002814:Chorda Tympani Nerve / Q000293:injuries*; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012472:Salivation; D013363:Submandibular Gland / Q000294:innervation / Q000473:pathology* / Q000503:physiopathology; D014433:Tympanoplasty / Q000009:adverse effects*; D055815:Young Adult
J Laryngol Otol. 2004 Feb;118(2):102-5
14979945
Auris Nasus Larynx. 2003 Feb;30(1):21-4
12589845
Acta Otolaryngol. 1982 Nov-Dec;94(5-6):461-5
7180419
Acta Med Croatica. 2002;56(1):11-5
12455448
J Nucl Med. 2001 Jan;42(1):38-43
11197978
Arch Oral Biol. 1988;33(4):281-90
3165263
Acta Otolaryngol. 1979 Jan-Feb;87(1-2):152-5
760373