Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease.
Cardiovascular diseases are the most common cause of death among the elderly in the Western world. Resveratrol (3,5,4'-trihydroxystilbene) is a plant-derived polyphenol that was shown to exert diverse anti-aging activity mimicking some of the molecular and functional effects of caloric restriction. This mini-review focuses on the molecular and cellular mechanisms activated by resveratrol in the vascular system, and explores the links between its anti-oxidative and anti-inflammatory effects, which could be exploited for the prevention or amelioration of vascular aging in the elderly.
Reynolds Oklahoma Center on Aging, Department of Physiology, Oklahoma City, USA. anna-csiszar@ouhsc.edu
Anna
A
Csiszar
D000375:Aging / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013267:Stilbenes; D000077185:Resveratrol
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