Antibacterial sesquiterpene lactone glucoside from seed pods of Bauhinia retusa.
From the seed pods of Bauhinia retusa, a new eudesmane sesquiterpene glucoside, 1-O-β-D-glucopyranosyl-9β,15-dihydroxy-5α,6βH-eudesma-3-ene-6α,12-olide (1), has been isolated together with three known compounds, 4'-hydroxy-7-methoxy flavane (2), β-sitosterol (3), and stigmasterol (4). The structures of isolated compounds were verified with the help of 1D, 2D NMR, and HR-ESI-MS spectroscopies. Compound 1 showed moderate antibacterial activity against Pseudomonas aeruginosa and Escherichia coli when a disc diffusion method is used.
Department of Chemistry, HNB Garhwal Central University Srinagar, Uttarakhand, India. sushsemwal@gmail.com
Sushma
S
Semwal
Rajni Kant
RK
Sharma
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D036481:Bauhinia / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007194:India; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012485:Salmonella typhi / Q000187:drug effects; D012639:Seeds / Q000737:chemistry; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
C556042:1-O-beta-D-glucopyranosyl-9beta,15-dihydroxy-5alpha,6betaH-eudesma-3-ene-6alpha,12-olide; D000900:Anti-Bacterial Agents; D005960:Glucosides; D007783:Lactones; D045787:Sesquiterpenes, Eudesmane