A biomimetic approach to the cylindrospermopsin alkaloids.
The tethered Biginelli condensation between hemiaminal 21 and β-keto ester 22 is reported, leading to a model tricyclic core of the cylindrospermopsin alkaloids.
School of Chemistry, Bangor University, Bangor, Gwynedd, UK LL33 0SE.
Daniel M
DM
Evans
Patrick J
PJ
Murphy
D000470:Alkaloids / Q000737:chemistry; D001427:Bacterial Toxins; D032701:Biomimetics; D000087522:Cyanobacteria Toxins; D046891:Cylindrospermopsis / Q000235:genetics; D019791:Guanidine / Q000737:chemistry; D005810:Multigene Family; D014498:Uracil / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry
D000470:Alkaloids; D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; C089595:cylindrospermopsin; D014498:Uracil; D019791:Guanidine