Antioxidant system and energy provision of the rat heart during aging depend on illumination regimen and are resistant to exogenous melatonin.
Activities of antioxidant enzymes, vitamin E level, lactate dehydrogenase isoenzyme spectrum, and effects of melatonin on these parameters were studied in the myocardium of rats aged 6, 12, 18, and 24 months exposed to different illumination regimens. The greatest number of changes was recorded in rats exposed to permanent illumination and light deprivation. Activity of SOD decreased with age, while catalase activity increased. Melatonin treatment did not modify activities of antioxidant enzymes and negligibly modified the level of tocopherol and isoenzyme spectrum of lactate dehydrogenase in rat heart.
Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, Russia. hizhkin84@mail.ru
E A
EA
Khizhkin
V A
VA
Ilukha
T N
TN
Ilyina
A R
AR
Unzhakov
I A
IA
Vinogradova
V N
VN
Anisimov
D000367:Age Factors; D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006321:Heart / Q000502:physiology*; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D017440:Photoperiod; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018709:Statistics, Nonparametric
D007527:Isoenzymes; D017382:Reactive Oxygen Species; D007770:L-Lactate Dehydrogenase; D008550:Melatonin