RNA virus harnesses microRNAs to seize host translation control.
Picornaviruses have evolved elaborate strategies to subvert host translation. In this issue of Cell Host and Microbe, Ho et al. (2011) report that enterovirus infection induces the synthesis of a transcription factor that enhances the synthesis of microRNA-141, which suppresses translation of the cap-binding protein, eIF4E, mRNA to inhibit cap-dependent translation.
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Teresa M
TM
Abraham
Peter
P
Sarnow