Control of NF-κB activity by proteolysis.
NF-κB transcription factors are critical regulators of many biological processes such as innate and adaptive immune responses, inflammation, cell proliferation and programmed cell death. This versatility necessitates a highly complex and tightly coordinated control of the signaling pathways leading to their activation. Here, we review the role of proteolysis in the regulation of NF-κB activity, more specifically the contribution of the well-known ubiquitin-proteasome system and the involvement of proteolytic activity of caspases and calpains.
Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. veronique.baud@inserm.fr
Véronique
V
Baud
Emmanuel
E
Derudder
D000818:Animals; D002154:Calpain / Q000502:physiology; D020169:Caspases / Q000502:physiology; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D016328:NF-kappa B / Q000502:physiology*; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D015398:Signal Transduction
D016328:NF-kappa B; D051550:I-kappa B Kinase; D002154:Calpain; D020169:Caspases; D046988:Proteasome Endopeptidase Complex