Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony.
Hepatitis B and hepatitis C are important causes of chronic liver disease globally. Although HBV/HCV coinfection is not uncommon, its epidemiology is poorly defined. Numerous studies provided evidence that coinfection accelerates liver disease progression and increases the risk of hepatocellular carcinoma. By applying new cell culture models to examine the interaction of both viruses, investigators concluded that HBV and HCV replicate in the same hepatocyte without interference. The roles of innate and adaptive immunity in determining the viral replication and disease outcomes still need rigorous investigation. To date, no standard-of-care recommendation exists for HBV/HCV coinfection. Pegylated interferon and ribavirin combination therapy demonstrated similar efficacy in suppressing HCV RNA in coinfection and HCV monoinfection. However, HBV reactivation during therapy can be a challenge. Future clinical trials evaluating the addition of a nucleoside/nucleotide analog for selective patients with HBV/HCV coinfection are essential for successful management of HBV/HCV coinfection.
Liver Center, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Shailaja
S
Jamma
Ghazi
G
Hussain
Daryl T-Y
DT
Lau
J Hepatol. 2003 Dec;39(6):1036-41
14642623
J Clin Virol. 2004 Mar;29(3):160-6
14962784
Cancer. 1994 Nov 1;74(9):2442-8
7922998
Hepatogastroenterology. 1997 Sep-Oct;44(17):1404-6
9356863
Gastroenterology. 2009 Feb;136(2):496-504.e3
19084016
Neth J Med. 2008 May;66(5):191-5
18490796
J Med Virol. 1998 Apr;54(4):249-55
9557290
J Clin Microbiol. 2002 Nov;40(11):4068-71
12409376
World J Gastroenterol. 2006 Jul 21;12(27):4406-10
16865787
J Hepatol. 2008 Nov;49(5):688-94
18490077
J Hepatol. 1998 Jan;28(1):27-33
9537860
Histopathology. 1993 Apr;22(4):319-25
8514275
J Med Virol. 1999 Jul;58(3):201-7
10447413
Gastroenterology. 1997 Jan;112(1):184-7
8978357
J Hepatol. 2009 Sep;51(3):446-57
19596477
Gastroenterology. 1993 Feb;104(2):549-55
8381098
J Interferon Cytokine Res. 1997 Aug;17(8):449-52
9282824
Liver Int. 2005 Apr;25(2):247-53
15780046
Int J Cancer. 2004 Dec 20;112(6):1075-80
15386355
Hepatology. 1997 Mar;25(3):719-27
9049225
Gastroenterology. 1994 Jul;107(1):189-95
8020661
J Hepatol. 2000 Nov;33(5):785-90
11097488
Gastroenterol Jpn. 1991 Jul;26 Suppl 3:192-5
1909266
Hepatology. 1991 Jul;14(1):64-7
1648540
J Hepatol. 2004 Dec;41(6):1064-5
15582146
Infection. 1992 Nov-Dec;20(6):316-9
1284057
Clin Infect Dis. 2003 Feb 15;36(4):528-32
12567314
Dig Dis Sci. 1982 Aug;27(8):762-4
6807662
J Hepatol. 2002 Dec;37(6):855-62
12445429
J Hepatol. 2009 Sep;51(3):423-5
19596479
Hepatology. 2003 Mar;37(3):568-76
12601355
J Gastroenterol Hepatol. 1999 Sep;14(9):893-8
10535471
Liver Int. 2009 Nov;29(10):1485-93
19602134
J Clin Gastroenterol. 2001 Jul;33(1):20-6
11418785
J Med Virol. 1997 Apr;51(4):313-8
9093946
N Engl J Med. 1999 Jul 1;341(1):22-6
10387938
Am J Gastroenterol. 2001 Oct;96(10):2973-7
11693335
Hepatology. 1994 Apr;19(4):836-40
8138254
Hepatology. 1995 Oct;22(4 Pt 1):1101-8
7557857
J Gastroenterol Hepatol. 2005 May;20(5):727-32
15853986
J Biol Chem. 2003 Jan 3;278(1):591-607
12401801
Hepatology. 2009 Jul;50(1):46-55
19333911
J Gastroenterol. 2009;44(4):359-64
19271112
Int J Cancer. 1998 Jan 30;75(3):347-54
9455792
Gastroenterology. 1994 Apr;106(4):1048-53
8143971
Cancer. 1999 May 15;85(10):2132-7
10326690
BMJ. 1993 Oct 30;307(6912):1095-7
8251805
Gastroenterology. 1993 Nov;105(5):1529-33
8224658
J Med Virol. 2007 Aug;79(8):1075-81
17596829
Turk J Gastroenterol. 2007 Mar;18(1):20-1
17450490
Am J Gastroenterol. 2000 Oct;95(10):2978-80
11051381
J Viral Hepat. 1995;2(1):39-45
7493293
Gastroenterology. 2004 Jan;126(1):102-10
14699492
Infection. 1991 Jul-Aug;19(4):250-1
1917039
J Viral Hepat. 2003 Mar;10(2):103-10
12614466
Antivir Ther. 2005;10(1):125-33
15751770
Hepatology. 2009 Apr;49(4):1090-7
19263473
N Engl J Med. 1999 Aug 19;341(8):556-62
10451460