The TB Structural Genomics Consortium: a decade of progress.
The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein-protein and protein-ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design.
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA.
Nicholas
N
Chim
Jeff E
JE
Habel
Jodie M
JM
Johnston
Inna
I
Krieger
Linda
L
Miallau
Ramasamy
R
Sankaranarayanan
Robert P
RP
Morse
John
J
Bruning
Stephanie
S
Swanson
Haelee
H
Kim
Chang-Yub
CY
Kim
Hongye
H
Li
Esther M
EM
Bulloch
Richard J
RJ
Payne
Alexandra
A
Manos-Turvey
Li-Wei
LW
Hung
Edward N
EN
Baker
J Shaun
JS
Lott
Michael N G
MN
James
Thomas C
TC
Terwilliger
David S
DS
Eisenberg
James C
JC
Sacchettini
Celia W
CW
Goulding
D001426:Bacterial Proteins / Q000737:chemistry; D018360:Crystallography, X-Ray; D030562:Databases, Protein; D015195:Drug Design; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D007391:International Cooperation; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism
D001426:Bacterial Proteins
FEMS Microbiol Rev. 2005 Sep;29(4):765-94
16102602
Structure. 2004 Apr;12(4):529-35
15062076
Nat Rev Microbiol. 2005 Jan;3(1):70-80
15608701
J Biol Chem. 1991 Jul 15;266(20):12971-5
2071583
J Biochem. 2000 Jul;128(1):29-38
10876155
Mol Microbiol. 1995 Feb;15(3):531-41
7783623
Proteins. 2000 Oct 1;41(1):47-57
10944393
J Struct Funct Genomics. 2009 Dec;10(4):291-301
19911309
Microbiol Rev. 1986 Sep;50(3):314-52
3534538
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9391-5
2251281
Nat Rev Cancer. 2006 Apr;6(4):321-30
16557283
J Biol Chem. 1998 Dec 18;273(51):34247-54
9852088
Biochemistry. 1993 May 18;32(19):5083-92
8494885
Cell Microbiol. 2006 Jan;8(1):10-22
16367862
J Mol Biol. 2008 Jan 25;375(4):1052-63
18062991
Infect Immun. 1991 Jul;59(7):2470-5
2050411
Mol Microbiol. 1998 Aug;29(4):1065-76
9767574
ACS Chem Biol. 2008 Oct 17;3(10):645-54
18785742
Mol Cell. 2003 Oct;12(4):913-23
14580342
J Mol Biol. 2005 Dec 9;354(4):927-39
16288916
Infect Disord Drug Targets. 2009 Nov;9(5):475-92
19594421
J Bacteriol. 2005 Sep;187(18):6300-8
16159762
Tuberculosis (Edinb). 2004;84(3-4):188-96
15207488
Infect Immun. 1994 Aug;62(8):3586-9
8039935
Proc Natl Acad Sci U S A. 1995 May 23;92(11):5189-93
7761471
Proc Natl Acad Sci U S A. 2004 May 18;101(20):7554-9
15131267
J Bacteriol. 2008 Aug;190(16):5672-80
18567661
J Biol Chem. 2004 Sep 17;279(38):40174-84
15247240
J Biol Chem. 2003 Nov 21;278(47):46446-51
12963713
J Virol. 1995 Apr;69(4):2451-61
7884893
Proc Natl Acad Sci U S A. 1986 May;83(10):3116-20
3517851
Mol Microbiol. 2002 Feb;43(3):717-31
11929527
Annu Rev Biochem. 2003;72:111-35
12524212
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12712-7
11606763
J Biol Chem. 1969 Dec 10;244(23):6388-94
4390967
J Biol Chem. 2005 Jan 28;280(4):2840-6
15520015
Nature. 1980 Jul 3;286(5768):79-80
6993961
Nat Prod Rep. 2007 Jun;24(3):511-22
17534527
Cell. 2003 Apr 18;113(2):183-93
12705867
Biochim Biophys Acta. 1998 Jun 10;1365(1-2):309-18
9693743
J Bacteriol. 1995 Oct;177(19):5644-52
7559354
Org Biomol Chem. 2005 Oct 21;3(20):3629-35
16211099
Mol Microbiol. 2003 Jun;48(5):1389-400
12787364
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14328-33
11717402
Nature. 1999 Nov 4;402(6757):86-90
10573422
J Mol Biol. 2010 Mar 12;396(5):1211-26
20060836
J Biol Chem. 2005 Aug 26;280(34):30063-72
15980067
J Bacteriol. 2009 Mar;191(5):1618-30
19114484
Chem Biol. 2008 May;15(5):459-66
18482698
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15629-34
16227431
Biochemistry. 2007 Jan 30;46(4):954-64
17240979
Protein Sci. 1993 May;2(5):717-26
8495194
Curr Drug Targets Infect Disord. 2002 Jun;2(2):121-41
12462144
Infect Immun. 1999 Apr;67(4):2035-9
10085056
Prog Lipid Res. 1995;34(4):267-342
8685242
Mol Cell. 2005 Aug 19;19(4):497-509
16109374
Nat Struct Biol. 2000 Aug;7(8):663-8
10932251
Mol Microbiol. 2008 Sep;69(5):1304-15
18643935
J Biol Chem. 1989 May 25;264(15):8597-601
2656685
J Mol Biol. 2010 Apr 9;397(4):979-90
20184895
Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):465-71
17372350
J Struct Biol. 2003 Apr;142(1):56-65
12718919
Microbiology (Reading). 2008 Jun;154(Pt 6):1616-1627
18524916
Science. 1999 Jul 30;285(5428):751-3
10427000
Infect Immun. 1990 Apr;58(4):1120-3
2180821
PLoS Genet. 2009 Dec;5(12):e1000767
20011113
Protein Sci. 2008 Nov;17(11):1935-45
18714089
Biochemistry. 2004 Dec 28;43(51):16067-75
15610001
Nat Protoc. 2007;2(9):2212-21
17853878
Infect Immun. 1997 Dec;65(12):5358-63
9393841
J Biosci. 2007 Apr;32(3):517-30
17536171
Methods Mol Biol. 2009;465:47-59
20560058
Cell. 1998 Oct 2;95(1):135-46
9778254
ChemMedChem. 2010 Jul 5;5(7):1067-79
20512795
Nat Med. 2004 Oct;10(10):1128-32
15448687
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1376-80
11171958
Cell. 2003 Jan 10;112(1):131-40
12526800
J Bacteriol. 1992 Aug;174(16):5317-23
1644759
J Biol Chem. 2003 Jan 17;278(3):1735-43
12393860
Tuberculosis (Edinb). 2003;83(4):223-49
12906835
J Bacteriol. 2006 Sep;188(17):6081-91
16923875
Bioinformatics. 2002;18 Suppl 1:S329-36
12169563
J Mol Biol. 2004 Feb 27;336(4):943-55
15095871
J Biol Chem. 2009 Jan 2;284(1):276-283
18952600
Protein Sci. 2006 Aug;15(8):2002-7
16877713
J Cell Sci. 2005 Oct 1;118(Pt 19):4327-32
16179604
Infect Immun. 2001 Sep;69(9):5936-9
11500477
J Biol Chem. 2006 Nov 17;281(46):35467-77
16971393
J Bacteriol. 1998 Apr;180(7):1947-50
9537397
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1;66(Pt 7):781-6
20606272
Nature. 1998 Jun 11;393(6685):537-44
9634230
Microbiology (Reading). 2005 Jan;151(Pt 1):5-14
15632420
J Bacteriol. 1997 Apr;179(8):2465-71
9098040
J Bacteriol. 1992 Aug;174(16):5309-16
1644758
J Bacteriol. 1996 Aug;178(15):4670-8
8755899
Structure. 2005 Jan;13(1):121-30
15642267
J Bacteriol. 2005 Oct;187(20):7062-71
16199577
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3963-7
18316738
Nat Med. 2005 Nov;11(11):1170-2
16205738
J Bacteriol. 2007 Sep;189(17):6089-92
17616596
Mol Microbiol. 2010 Mar;75(6):1529-38
20180905
PLoS Comput Biol. 2008 Sep 12;4(9):e1000174
18787688
Biochemistry. 2002 Feb 19;41(7):2198-208
11841211
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15835-40
17035505
Nucleic Acids Res. 2007 Jan;35(Database issue):D760-5
17099226
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9876-80
7937909
Bioorg Med Chem Lett. 2010 Sep 15;20(18):5411-3
20709548
J Biol Chem. 2004 Apr 16;279(16):16471-8
14734548
Nucleic Acids Res. 2005 Feb 17;33(3):966-76
15718296
Nat Methods. 2009 Aug;6(8):606-12
19620974
Biochem Soc Trans. 2003 Jun;31(Pt 3):625-30
12773169
Nature. 2000 Aug 17;406(6797):735-8
10963599
Infect Immun. 2000 Feb;68(2):443-8
10639402
Biometals. 2007 Jun;20(3-4):603-13
17268821
J Mol Biol. 2008 Jun 27;380(1):107-19
18501926
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9819-24
20439709
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3393-7
14990798
Biochem J. 2005 Jan 15;385(Pt 2):565-73
15352873
J Biol Chem. 2008 Nov 7;283(45):30957-63
18713745
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2896-901
10077608
J Bacteriol. 1995 Jun;177(11):3004-9
7768795
Org Biomol Chem. 2005 Jun 21;3(12):2271-81
16010361
J Bacteriol. 1996 Nov;178(21):6394-8
8892850
J Biol Chem. 1997 Dec 5;272(49):30780-6
9388218
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4285-8
10200254
Trends Biochem Sci. 1998 Sep;23(9):324-8
9787636
J Biol Chem. 2004 Jan 2;279(1):436-43
14570922
J Bacteriol. 1989 Dec;171(12):6414-22
2687233
PLoS Comput Biol. 2006 Jun 9;2(6):e61
16789813
Infect Immun. 2005 Jun;73(6):3754-7
15908407
Genome Biol. 2003;4(9):R59
12952538
In Silico Biol. 1999;1(2):93-108
11471247
Annu Rev Microbiol. 2001;55:139-63
11544352
Infect Immun. 1998 Nov;66(11):5215-23
9784525
J Mol Biol. 2010 Jan 22;395(3):595-608
19917297
Blood. 2005 Apr 1;105(7):2802-11
15591114
Biometals. 2007 Jun;20(3-4):333-45
17387580
Anal Biochem. 2004 Sep 1;332(1):153-9
15301960
Genome Biol. 2004;5(5):R35
15128449
Nature. 2001 Jul 5;412(6842):83-6
11452311
Trends Biochem Sci. 2005 Dec;30(12):672-9
16257530
J Bacteriol. 2010 Mar;192(5):1279-91
20061486
Proc Natl Acad Sci U S A. 1998 May 26;95(11):5849-56
9600883
J Biol Chem. 2004 Jan 30;279(5):3516-24
14597624
Cell. 2009 Dec 11;139(6):1084-95
20005802
J Bacteriol. 2006 Feb;188(3):1071-80
16428411
Proc Natl Acad Sci U S A. 1983 Aug;80(15):4784-8
6308648
Infect Disord Drug Targets. 2007 Jun;7(2):127-39
17970224
Microbiology (Reading). 2010 Jan;156(Pt 1):81-87
19797356
Nucleic Acids Res. 2001 Mar 1;29(5):1216-21
11222772
Protein Sci. 2007 Aug;16(8):1676-88
17656583
Biochem Biophys Res Commun. 2001 May 18;283(4):849-53
11350062