Use of amino-terminal pro-B type natriuretic peptide as the parameter for long-term monitoring of water overload in patient with chronic kidney diseases.
OBJECTIVE
To analyze usefulness of measurement amino-terminal pro-B type natriuretic peptide of (NT pro-BNP) as the one of parameters of water overload in patients with chronic kidney diseases.


METHODS
A total number of 277 patients with chronic kidney diseases (CKD) were followed up in the period often years between January 2000 and July 2010. Patients with creatinine clearance of 60 ml/min or less were included in the study. Changes of creatinine clearance, and in last five years changes of NT pro-BNP were followed. Water overload was analyzed using chest x-ray in relation with concentration of NT pro-BNP in the blood.


RESULTS
Decrease of clearance of creatinine ranged from average 54.7 ml/min in the first year to 14.6 ml/min in the fifth year of the monitoring. Average NT pro-BNP level in patients without any sign of water overload was 94 pg/ml (SD 21), mean value in those with Kerley lines was 231 pg/ml/L (SD 64), in those with clear signs of water overload but without pleural effusion it was 525 pg/ml (SD 223), and in those with water retention including pleural effusion it was 1606 pg/ml (SD 1134). Using test of multiple correlation a statistically significant correlation between X-ray signs of water overload and NT pro-BNP concentration was shown, p < 0.05.


CONCLUSIONS
Measurement of NT pro-BNP was increased in the beginning of water overload in patients with CKD. Increased value of NT pro-BNP may be found earlier than any other signs of water overload. NT pro-BNP was a useful parameter in estimation of water overload in these patients.
Department of Internal Medicine, General Hospital Tesanj, Tesanj, Bosnia and Herzegovina. pbesim@bih.net.ba
Besim
B
Prnjavorac
Kadrija
K
Abduzaimović
Jasna
J
Jukić
Rifat
R
Sejdinović
Ekrema
E
Mujarić
Nedzada
N
Irejiz
Almira
A
Hadzović-Dzuvo
Radivoj
R
Jadrić
Adlija
A
Causević
Sabina
S
Semiz
Tamer
T
Bego
Maja
M
Malenica
D015415:Biomarkers / Q000097:blood; D001834:Body Water / Q000378:metabolism; D002908:Chronic Disease; D003404:Creatinine / Q000032:analysis; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D014527:Uric Acid / Q000097:blood; D014883:Water-Electrolyte Imbalance / Q000150:complications / Q000175:diagnosis* / Q000209:etiology
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014527:Uric Acid; D003404:Creatinine