Long chain omega 3 polyunsaturated fatty acids supplementation in the treatment of elderly depression: effects on depressive symptoms, on phospholipids fatty acids profile and on health-related quality of life.
OBJECTIVE
Recent observations showed that long chain omega 3 polyunsaturated fatty acids (n-3 LCPUFA) could represent a potential treatment for elderly depression. To determine if a n-3 LCPUFA containing supplement improves depressive symptoms, changes phospholipids acids profile and ameliorates Health related quality of life (HRQoL) in depressed elderly patients.


METHODS
Two-months, randomized, double-blind, placebo-controlled trial.


METHODS
Nursing home in Pavia, Italy.


METHODS
Forty-six depressed females, aged 66-95 years.


METHODS
22 depressed females were included in the intervention group (n-3 group, that received 2.5 g/day of n-3 LCPUFA, with 1.67 grams of EPA and 0.83 grams of DHA), and 24 patients in the placebo group. The primary endpoint was the improvement of depressive symptoms as evaluated by Geriatric Depression Scale (GDS). Secondary endpoints were the evaluation of modifications of erythrocyte membrane phospholipids fatty acid profile and of of HRQoL, by using the Short-Form 36-Item Health Survey (SF-36). All parameters were assessed before and after the treatment period of 8 weeks.


RESULTS
The mean GDS at 2 months was significantly lowered only for the n-3 group. SF-36 physical and mental components were significantly increased in the intervention group. Compliance was good, as confirmed by erythrocyte membrane phospholipid FA concentrations, with significant increase of EPA and DHA in the intervention group.


CONCLUSIONS
The supplementation of n-3 LCPUFA in elderly female patients reduces the occurrence of depressive symptoms, improves phospholipids fatty acids profile and health-related quality of life.
Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, Azienda di Servizi alla Persona di Pavia, University of Pavia Istituto di Cura Santa Margherita, Via Emilia 32, 27100 Pavia, Italy. serv.nutrizione@asppavia.it
M
M
Rondanelli
A
A
Giacosa
A
A
Opizzi
C
C
Pelucchi
C
C
La Vecchia
G
G
Montorfano
M
M
Negroni
B
B
Berra
P
P
Politi
A M
AM
Rizzo
D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000097:blood / Q000188:drug therapy*; D004041:Dietary Fats / Q000008:administration & dosage*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects*; D005227:Fatty Acids / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D010349:Patient Compliance; D010743:Phospholipids / Q000737:chemistry*; D011788:Quality of Life
D004041:Dietary Fats; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D010743:Phospholipids
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