[Recent knowledge on the pathogenesis of nonalcoholic fatty liver disease. Role of genetic factors].
The Non-Alcoholic Fatty Liver Disease (NAFLD) is the most frequent cause of chronic liver disease in West, potentially associated with an elevated morbidity and mortality. The search is busy in to identify genetic factors of progression in people with same environmental risk factors. Objective of this review is to analyze the data from association studies on the role of the genetic factors in NAFLD. The available studies are not conclusive in to identify candidate genes, because conducted on small populations and with not well-done designs. Identification of genetic risk profiles for NAFLD progression could help to individualize the patients treatment and follow-up.
Istituto di Medicina Interna, Università Cattolica del Sacro Cuore, Roma. luca.miele@rm.unicatt.it
Luca
L
Miele
Consuelo
C
Cefalo
Alessandra
A
Forgione
Giovanni
G
Gasbarrini
Antonio
A
Grieco
D005234:Fatty Liver / Q000235:genetics*; D006801:Humans