Functions of Runx in IgA class switch recombination.
Runt-related (Runx) transcriptional regulators play essential roles in various cell fate determination processes, and dysfunction of these regulators causes many human diseases. Considerable insight into the functions of Runx proteins was provided mainly by studies of hematopoietic and skeletal disorders. Recently, extensive investigations have revealed new functions of these transcription factors in immune cell differentiation and functioning. In the present review, we discuss the mechanisms of selective IgA production in the intestine and report the involvement of Runx proteins in this process.
Translational Research Center, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan. msugai@virus.kyoto-u.ac.jp
Manabu
M
Sugai
Kakeru
K
Watanabe
Yukiko
Y
Nambu
Tatsunari
T
Hayashi
Akira
A
Shimizu
D000818:Animals; D050657:Core Binding Factor alpha Subunits / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008954:Models, Biological
D050657:Core Binding Factor alpha Subunits; D007070:Immunoglobulin A