The association of Caveolin-1 genotypes with oral cancer susceptibility in Taiwan.
BACKGROUND
Caveolin-1, which has been proposed as a candidate tumor suppressor, plays a regulatory role in several signaling pathways. The aim of this study was to evaluate the association between oral cancer susceptibility and Cav-1 genotypes. In this hospital-based case-control study, the association of Cav-1 polymorphisms with oral cancer risk in a central Taiwanese population was investigated.


METHODS
Six hundred patients with oral cancer and 620 age- and sex-matched healthy control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
There were significant differences between oral cancer and control groups in the distributions of their genotypes (P = 1.7 × 10(-18) and 2.6 × 10(-4)) and allelic frequencies (P = 3.3 × 10(-19) and 9.5 × 10(-6)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms, respectively. As for the combined genotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.72-fold (95% confidence interval = 0.52-0.99) decreased risk of oral cancer compared to those with GG/TT, while those of any other combinations were of increased risk. The presence of metastasis was also correlated to both Cav-1 G14713A AA and Cav-1 T29107A TT genotypes.


CONCLUSIONS
Cav-1 is involved in oral cancer, the A allele of the Cav-1 G14713A is risky, the A allele of the Cav-1 T29107A is protective, and AA/TT on these two polymorphisms may be the most risky combined genotype for the development of oral cancer and may be novel risk markers for early detection and prediction of distant metastasis.
Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan. datian@mail.cmuh.org.tw
Da-Tian
DT
Bau
Ming Hsui
MH
Tsai
Yung-An
YA
Tsou
Chung-Hsing
CH
Wang
Chia-Wen
CW
Tsai
Shung-Shung
SS
Sun
Chun-Hung
CH
Hua
Song-Kun
SK
Shyue
Ru-Yin
RY
Tsai
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D051242:Caveolin 1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000235:genetics*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D013624:Taiwan / Q000453:epidemiology
D014408:Biomarkers, Tumor; D051242:Caveolin 1