Transcriptional control of muscle proteins.
The development of a muscle cell from a precursor cell involves a massive adjustment of gene expression such that over 50 previously silent genes are expressed to produce the muscle proteins required for contractile functions. In differentiated muscle, hormonal and physiologic stimuli modify the expression of these proteins primarily at the level of transcription. How does the cell regulate the switching on and switching off of specific genes to produce the muscle phenotype and respond to new conditions?
Department of Cardiology, St. Elizabeth's Hospital, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.
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