Clinical features and successful management of suicidal digoxin toxicity without use of digoxin-specific antibody (Fab) fragments--is it possible?
A retrospective study of 147 consecutive cases of suicidal digoxin poisoning was undertaken in order to determine the severity and outcome of toxicity without use of digoxin-specific Fab fragments. This study showed that suicidal digoxin poisoning in young patients is usually mild to moderate; even underlying cardiac disease and chronic use of digoxin has no effect on the severity of toxicity and incidence of lethal dysrhythmia in these cases. This type of toxicity responds appropriately to conventional treatment.
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Hazrat Rasoul Akram Hospital, Niayesh Street, Sattar-Khan Avenue, 1445613131, Tehran, Iran. sanaeizadeh@gmail.com
Hossein
H
Sanaei-Zadeh
Zahra
Z
Valian
Nasim
N
Zamani
Hoorvash
H
Farajidana
Babak
B
Mostafazadeh
D000293:Adolescent; D000328:Adult; D004077:Digoxin / Q000097:blood / Q000506:poisoning*; D004562:Electrocardiography; D005260:Female; D005440:Fluid Therapy; D006331:Heart Diseases / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007492:Iran / Q000453:epidemiology; D008297:Male; D011188:Potassium / Q000097:blood; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
D007140:Immunoglobulin Fab Fragments; D007155:Immunologic Factors; D004077:Digoxin; D011188:Potassium