Gold-catalyzed stereoselective synthesis of azacyclic compounds through a redox/[2 + 2 + 1] cycloaddition cascade of nitroalkyne substrates.
We report a new redox/cycloaddition cascade on readily available 1-alkynyl-2-nitrobenzenes that produces complex azacyclic compounds stereoselectively. The core structures of the resulting products are constructed through a formal [2 + 2 + 1] cycloaddition among α-carbonyl carbenoids, nitroso species, and external alkenes.
Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan, ROC.
Appaso Mahadev
AM
Jadhav
Sabyasachi
S
Bhunia
Hsin-Yi
HY
Liao
Rai-Shung
RS
Liu