Age-associated characteristics of vasomotor regulation of the pia mater arteries in rats.
The endothelium-dependent and myogenic reactions of pia mater arteries of the 1st-5th branching orders were studied in 1-, 3-, and 24-month-old rats by biomicroscopy method. The endothelium-independent (myogenic) reaction predominated in the 1st-3rd order branches and the endothelium-dependent vascular reaction in the 5th order branches of 3-month-old rats. Both regulatory mechanisms were equally developed in the 4th order branches. In 1-month-old rats, the endothelium-dependent reaction was more active in the majority of branches. In 24-month-old rats, this reaction was significantly higher than the endothelium-independent one only in the 4th and 5th order branches. In contrast to 3-month-old rats, the myogenic reaction of 24-month-old animals predominated in the 1st and 2nd order branches and the endothelium-dependent one in the 4th and 5th order branches. Vascular reactivity of 24-month-old rats was lower than in younger rats in all cases.
Department of Human Anatomy, Vladivostok State Medical University, Russia.
V M
VM
Chertok
A E
AE
Kotsyuba
D000109:Acetylcholine / Q000494:pharmacology; D000367:Age Factors; D000818:Animals; D008576:Meningeal Arteries / Q000502:physiology*; D008853:Microscopy; D019331:NG-Nitroarginine Methyl Ester; D005996:Nitroglycerin / Q000494:pharmacology; D010841:Pia Mater / Q000098:blood supply*; D051381:Rats; D012039:Regional Blood Flow / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects*; D014666:Vasomotor System / Q000502:physiology*
D005996:Nitroglycerin; D000109:Acetylcholine; D019331:NG-Nitroarginine Methyl Ester