Signaling to myosin regulatory light chain in sarcomeres.
Myosin regulatory light chain (RLC) phosphorylation in skeletal and cardiac muscles modulates Ca(2+)-dependent troponin regulation of contraction. RLC is phosphorylated by a dedicated Ca(2+)-dependent myosin light chain kinase in fast skeletal muscle, where biochemical properties of RLC kinase and phosphatase converge to provide a biochemical memory for RLC phosphorylation and post-activation potentiation of force development. The recent identification of cardiac-specific myosin light chain kinase necessary for basal RLC phosphorylation and another potential RLC kinase (zipper-interacting protein kinase) provides opportunities for new approaches to study signaling pathways related to the physiological function of RLC phosphorylation and its importance in cardiac muscle disease.
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
Kristine E
KE
Kamm
James T
JT
Stull
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D018994:Myosin Light Chains / Q000378:metabolism*; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism*; D010766:Phosphorylation; D012518:Sarcomeres / Q000378:metabolism*; D015398:Signal Transduction
D018994:Myosin Light Chains; D009219:Myosin-Light-Chain Kinase; D002118:Calcium
FASEB J. 2009 Mar;23(3):855-65
18987303
Cell. 2001 Feb 23;104(4):557-67
11239412
FEBS Lett. 2000 Apr 21;472(1):148-52
10781823
Gastroenterology. 2008 Aug;135(2):610-20
18586037
Cardiovasc Res. 2008 Mar 1;77(4):649-58
18055579
J Biol Chem. 2009 Feb 20;284(8):5097-106
19106098
Biochem Biophys Res Commun. 2008 Apr 25;369(1):149-56
18155661
Basic Res Cardiol. 1988 Jul-Aug;83(4):350-9
3190654
J Biol Chem. 2005 Mar 11;280(10):9363-74
15611134
Circ J. 2010 Jan;74(1):120-8
19966500
J Struct Biol. 1998;122(1-2):149-61
9724616
Heart Fail Rev. 2005 Sep;10(3):237-48
16416046
Biochem J. 1980 Jun 15;188(3):763-8
7470033
J Appl Physiol (1985). 1989 Dec;67(6):2447-53
2606853
J Appl Physiol (1985). 1998 Jan;84(1):236-43
9451641
Annu Rev Biochem. 2006;75:189-210
16756490
J Cell Sci. 2005 Aug 15;118(Pt 16):3675-83
16076902
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2419-24
11226254
Cardiovasc Res. 2009 Apr 1;82(1):84-92
19150977
J Muscle Res Cell Motil. 2010 Dec;31(4):267-77
20972612
J Struct Biol. 1998;122(1-2):139-48
9724615
J Biol Chem. 2010 Feb 19;285(8):5522-31
20018858
Circ Res. 2008 Mar 14;102(5):571-80
18202317
J Biol Chem. 1992 Mar 15;267(8):5346-54
1544916
Biochemistry. 1999 Mar 9;38(10):3127-32
10074367
J Biol Chem. 2007 Feb 16;282(7):4884-4893
17158456
Am J Physiol. 1980 Dec;239(6):H756-64
7446749
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2386-90
18252826
Physiol Rev. 2003 Oct;83(4):1325-58
14506307
Biochemistry. 1980 Nov 25;19(24):5608-14
6893940
Am J Physiol. 1997 Jun;272(6 Pt 2):R1980-4
9227617
Eur J Heart Fail. 2011 Jan;13(1):83-92
20810473
Am J Physiol. 1984 Nov;247(5 Pt 1):C462-71
6548609
J Biol Chem. 2000 Feb 11;275(6):4199-204
10660583
Circulation. 2010 Sep 14;122(11):1130-3
20837938
Biochim Biophys Acta. 1979 Nov 1;587(4):628-37
228754
J Biol Chem. 2001 Feb 16;276(7):4535-8
11124250
Biochemistry. 2003 Sep 16;42(36):10579-88
12962481
J Biol Chem. 2011 Mar 25;286(12):9935-40
21257760
J Mol Cell Cardiol. 2010 May;48(5):866-75
19962384
Cell Signal. 2005 Nov;17(11):1313-22
16005610
Prog Biophys Mol Biol. 2008 Jun-Jul;97(2-3):250-67
18466959
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8237-41
20404178
Biochem Biophys Res Commun. 1979 Sep 12;90(1):164-70
496969
Nature. 1998 Oct 29;395(6705):863-9
9804419
Biophys J. 2002 Jul;83(1):359-70
12080126
J Mol Cell Cardiol. 2006 Aug;41(2):330-9
16806259
Cardiovasc Res. 2003 Jan;57(1):37-47
12504812
J Clin Invest. 2007 Oct;117(10):2812-24
17885681
J Appl Physiol (1985). 2002 Apr;92(4):1661-70
11896035
Exerc Sport Sci Rev. 2002 Jul;30(3):138-43
12150573
J Physiol. 1968 Jul;197(2):461-77
5716854
J Biol Chem. 2001 Mar 9;276(10):7086-92
11102452
J Appl Physiol (1985). 2007 Oct;103(4):1318-25
17641222
Nature. 1976 Dec 23-30;264(5588):801-2
1012327
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17519-24
16299103
J Biol Chem. 2001 Feb 16;276(7):4527-30
11096123
Trends Cell Biol. 2000 Aug;10(8):322-8
10884684
Cardiovasc Res. 2010 Nov 1;88(2):334-43
20615916
Science. 1992 May 1;256(5057):632-8
1585175
J Gen Physiol. 1989 May;93(5):855-83
2661721
J Physiol. 2010 Mar 15;588(Pt 6):981-93
20123786
J Mol Med (Berl). 1999 Jul;77(7):544-55
10494800
J Biol Chem. 2007 Jul 13;282(28):20447-54
17504755
Biochemistry. 1998 Oct 6;37(40):13997-4004
9760234
Am J Physiol. 1982 Mar;242(3):C234-41
7065172
Biochemistry. 1998 Dec 22;37(51):17810-7
9922147
J Biol Chem. 2010 May 28;285(22):16403-7
20339003
J Biol Chem. 2009 Jun 5;284(23):15541-8
19349274
Am J Respir Cell Mol Biol. 2011 Jan;44(1):40-52
20139351
J Gen Physiol. 2006 Sep;128(3):261-72
16908724
J Biol Chem. 2000 Sep 1;275(35):26665-73
10842170
J Biol Chem. 2011 Mar 25;286(12):9913-9
21257752
Cardiovasc Res. 2005 Jan 1;65(1):211-20
15621049
Cell. 2001 Nov 30;107(5):631-41
11733062
Mol Cell Biol. 1998 Mar;18(3):1642-51
9488481
J Biol Chem. 1995 Apr 28;270(17):10125-35
7730316
J Biol Chem. 2008 Jul 11;283(28):19748-56
18474588
Biophys J. 1981 Jun;34(3):559-69
7195747
Am J Physiol. 1993 May;264(5 Pt 1):C1085-95
8388631
J Biol Chem. 1999 Jul 23;274(30):21085-94
10409661
Biochem J. 1981 Jul 1;197(1):185-93
7317029
Can J Physiol Pharmacol. 2007 Jan;85(1):79-87
17487247
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2712-8
15331360
J Muscle Res Cell Motil. 1997 Feb;18(1):1-16
9147985
J Mol Cell Cardiol. 1986 Jan;18(1):31-7
3754013
Cell Signal. 2006 Sep;18(9):1408-16
16431080
J Biol Chem. 2010 Feb 19;285(8):5122-6
20038585
J Biol Chem. 2004 Oct 1;279(40):42055-61
15292222
Annu Rev Physiol. 2005;67:39-67
15709952
J Biol Chem. 2010 Dec 24;285(52):40819-29
20943660
Biochemistry. 1997 May 20;36(20):6017-23
9166772
Acta Physiol Scand. 1995 Jul;154(3):343-53
7572232
Biochem J. 1986 Nov 15;240(1):205-14
3827840