Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.
Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles.
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.
Tumena W
TW
Corrah
Nilu
N
Goonetilleke
Jakub
J
Kopycinski
Steven G
SG
Deeks
Myron S
MS
Cohen
Persephone
P
Borrow
Andrew
A
McMichael
Simon
S
Brackenridge
D015870:Gene Expression; D015497:HIV-1 / Q000276:immunology*; D015236:HLA-C Antigens / Q000096:biosynthesis*; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D050436:Regulatory Elements, Transcriptional; D019562:Viral Load
D015236:HLA-C Antigens
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