Many paths to the same end: histone transcripts recruit canonical initiation factors through unconventional interactions.
In this issue of Molecular Cell, Eriani and colleagues show that histone transcripts recruit translation initiation factors through an alternate pathway reminiscent of viral translation, suggesting a broader role for noncanonical translation initiation on cellular transcripts (Martin et al., 2011).
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA. ingolia@ciwemb.edu
Nicholas
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Ingolia