[Testicular mixed nonseminomatous germ cell cancer: a case report and review of the literature].
OBJECTIVE
Testicular mixed nonseminomatous germ cell cancer (TMNGCC) is rarely reported. This study aimed to explore the clinical symptoms, pathological characteristics and treatment methods of TMNGCC.


METHODS
We analyzed the clinical data of 1 case of TMNGCC, observed its pathological characteristics under the light microscope by histology, cytochemistry, immunohistochemistry and immune marking, and investigated the clinical features of such tumors by reviewing the relevant literature.


RESULTS
The patient presented with a chief complaint of painless testicular swelling for 3 years. Histopathological examinations revealed a tumor of papillary, fissural or adenoid structure, with large polygonal or columnar cells with one or more irregular vesicular nuclei, the nuclear membrane clear, the cytoplasm eosinophilic or basophilic, and the interstitium infiltrated by a few lymphocytes. Here are the immunohistochemical results: CD117 -, CK8-18 + +, CD30 + +, CK + + +, vimentin -, PLAP +/-, P53 +, AFP + and EMA + +. The tumor was pathologically diagnosed as teratogenic embryonic testicular cancer, and treated by radical surgery, followed by adjuvant chemotherapy according to the treatment of TMNGCC. One-year follow-up found the patient to be alive.


CONCLUSIONS
TMNGCC is a rare malignant tumor, mostly with unobvious clinical symptoms. Its diagnosis primarily depends on physical examination, ultrasonography, CT, and measurement of serum tumor markers; its confirmation necessitates pathological examination, and its first-choice treatment is surgical resection.
Department of Urology, The Ninth Affiliated Hospital of China Medical University, Benxi, Liaoning 117000, China. zxcv630426@sina.com
Quan-Ming
QM
Ding
Wei
W
Liang
Gang
G
Wang
Yang
Y
Lu
Cheng-Dong
CD
Jin
Hong-Liang
HL
Ren
Hao-Bin
HB
Zhang
Zhong-Kai
ZK
Qiu
Zhe
Z
Su
D000328:Adult; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D018239:Seminoma / Q000473:pathology; D013736:Testicular Neoplasms / Q000473:pathology