Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury.
Mice that are deficient in classical major histocompatibility complex class I (MHCI) have abnormalities in synaptic plasticity and neurodevelopment and have more extensive loss of synapses and reduced axon regeneration after sciatic nerve transection, suggesting that MHCI participates in maintaining synapses and axon regeneration. Little is known about the biological consequences of up-regulating MHCI's expression on neurons. To understand MHCI's neurobiological activity better, and in particular its role in neurorepair after injury, we have studied neurorepair in a transgenic mouse model in which classical MHCI expression is up-regulated only on neurons. Using a well-established spinal cord injury (SCI) model, we observed that transgenic mice with elevated neuronal MHCI expression had significantly better recovery of locomotor abilities after SCI than wild-type mice. Although previous studies have implicated inflammation as both deleterious and beneficial for recovery after SCI, our results point directly to enhanced neuronal MHCI expression as a beneficial factor for promoting recovery of locomotor function after SCI.
Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA.
M Selvan
MS
Joseph
Tina
T
Bilousova
Sharon
S
Zdunowski
Zhongqi-Phyllis
ZP
Wu
Blake
B
Middleton
Maia
M
Boudzinskaia
Bonnie
B
Wong
Noore
N
Ali
Hui
H
Zhong
Jing
J
Yong
Lorraine
L
Washburn
Nathalie
N
Escande-Beillard
Hoa
H
Dang
V Reggie
VR
Edgerton
Niranjala J K
NJ
Tillakaratne
Daniel L
DL
Kaufman
D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005080:Exercise Test / Q000379:methods; D007839:Functional Laterality; D005786:Gene Expression Regulation / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D008124:Locomotion / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000235:genetics; D020127:Recovery of Function / Q000235:genetics / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology*
D015395:Histocompatibility Antigens Class I; D010751:Phosphopyruvate Hydratase
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