Proto-oncogenes and cardiac development.
Proto-oncogene products participate in signaling processes that extend from the cell surface to the nucleus. Recent investigations have focused attention on the role that proto-oncogenes play in the proliferation, differentiation, and hypertrophic growth of cardiac myocytes. Such studies suggest a cause-and-effect relationship between aberrations in proto-oncogene expression and abnormalities in myocyte growth and differentiation.
Departments of Medicine and Human Genetics, University of Pennsylvania Medical Center, Philadelphia, PA 19104-6060, USA.
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Matiuck
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Swain