Proteins mediating collagen biosynthesis and accumulation in arterial repair: novel targets for anti-restenosis therapy.
Events contributing to restenosis after coronary interventions include platelet aggregation, inflammatory cell infiltration, growth factor release, and accumulation of smooth muscle cells (SMCs) and extracellular matrix (ECM). The ECM is composed of various collagen subtypes and proteoglycans and over time constitutes the major component of the mature restenotic plaque. The pathophysiology of collagen accumulation in the ECM during arterial restenosis is reviewed. Factors regulating collagen synthesis and degradation, including various cytokines and growth factors involved in the process, may be targets for therapies aimed at prevention of in-stent restenosis.
Schulich Heart Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room A-253, Toronto, Ontario, Canada M4N 3M5.
Azriel B
AB
Osherov
Lara
L
Gotha
Asim N
AN
Cheema
Beiping
B
Qiang
Bradley H
BH
Strauss
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000295:instrumentation; D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism*; D017364:Collagenases / Q000378:metabolism; D023903:Coronary Restenosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D023921:Coronary Stenosis / Q000628:therapy*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D008249:Protein-Lysine 6-Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D015607:Stents
D002317:Cardiovascular Agents; D016207:Cytokines; D004791:Enzyme Inhibitors; D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D061965:Matrix Metalloproteinase Inhibitors; D003094:Collagen; D008249:Protein-Lysine 6-Oxidase; D017364:Collagenases