Identification of human miRNA precursors that resemble box C/D snoRNAs.
There are two main classes of small nucleolar RNAs (snoRNAs): the box C/D snoRNAs and the box H/ACA snoRNAs that function as guide RNAs to direct sequence-specific modification of rRNA precursors and other nucleolar RNA targets. A previous computational and biochemical analysis revealed a possible evolutionary relationship between miRNA precursors and some box H/ACA snoRNAs. Here, we investigate a similar evolutionary relationship between a subset of miRNA precursors and box C/D snoRNAs. Computational analyses identified 84 intronic miRNAs that are encoded within either box C/D snoRNAs, or in precursors showing similarity to box C/D snoRNAs. Predictions of the folded structures of these box C/D snoRNA-like miRNA precursors resemble the structures of known box C/D snoRNAs, with the boxes C and D often in close proximity in the folded molecule. All five box C/D snoRNA-like miRNA precursors tested (miR-27b, miR-16-1, mir-28, miR-31 and let-7g) bind to fibrillarin, a specific protein component of functional box C/D snoRNP complexes. The data suggest that a subset of small regulatory RNAs may have evolved from box C/D snoRNAs.
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Motoharu
M
Ono
Michelle S
MS
Scott
Kayo
K
Yamada
Fabio
F
Avolio
Geoffrey J
GJ
Barton
Angus I
AI
Lamond
D001483:Base Sequence; D002466:Cell Nucleolus / Q000235:genetics; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D012322:RNA Precursors / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D020537:RNA, Small Nucleolar / Q000737:chemistry* / Q000378:metabolism
D002868:Chromosomal Proteins, Non-Histone; D035683:MicroRNAs; D012322:RNA Precursors; D020537:RNA, Small Nucleolar; C047458:fibrillarin
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