Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life.
Maternal HIV-1 status and antiretroviral drug exposure may influence the haematological profiles of infants. We recruited infants from 118 uninfected control women and from 483 HIV-1 infected women who received no antiretroviral drugs (n=28), or received single-dose Nevirapine (sdNVP) (n=424) or triple-drug combination therapy (n=31) to reduce HIV-1 transmission. Blood was drawn from infants within 24 hours of delivery or 6-12 weeks post-delivery and full blood counts performed using a fully automated AcT-5-diff haematology analyser and reference controls. Exposed uninfected (EU; no NVP) differed from control infants only in having lower basophil counts and percentages. In all infant groups, leukocyte profiles showed characteristic quantitative changes with age in the first 6 weeks of life. HIV-1 infected infants displayed by 6 weeks elevations in white blood cells, lymphocyte, monocyte and basophil counts, and monocyte and basophil percentages, when compared to EU infants. At birth EU NVP-treated infants exhibited elevated monocyte percentages and counts and basophil counts that did not persist at 6 weeks. Interestingly, EU newborns of mothers with high CD4 counts (> 500 cells/μl) that had taken sdNVP had significantly elevated white blood cell, monocyte and basophil counts when compared to newborn infants of mothers with similar CD4 counts that had not taken sdNVP; this was not evident in infants of mothers with CD4 counts <200 cells/μl. These previously undescribed features may affect immune response capability in early life and clinical consequences of such changes need to be further investigated.
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, University of the Witwatersrand, Gauteng, South Africa.
Diana B
DB
Schramm
Fiona
F
Anthony
Busani
B
Mathebula
Gayle
G
Sherman
Ashraf
A
Coovadia
Glenda E
GE
Gray
Louise
L
Kuhn
Caroline T
CT
Tiemessen
J Acquir Immune Defic Syndr. 2007 May 1;45(1):43-51
17356471
Clin Diagn Lab Immunol. 1999 May;6(3):410-4
10225845
Obstet Gynecol. 2004 Mar;103(3):546-50
14990420
HIV Med. 2007 Sep;8(6):357-66
17661843
Eur J Obstet Gynecol Reprod Biol. 2006 Sep-Oct;128(1-2):59-63
16876310
AIDS. 2003 Aug 15;17(12):1769-85
12891063
Clin Infect Dis. 2002 Jan 15;34(2):267-76
11740717
Ann Trop Paediatr. 2004 Dec;24(4):301-9
15720887
J Acquir Immune Defic Syndr. 2007 Apr 1;44(4):371-6
17259905
J Acquir Immune Defic Syndr. 2007 Jul 1;45(3):365-8
17592340
AIDS. 2004 Oct 21;18(15):2009-17
15577622
Pediatrics. 2001 Jan;107(1):E5
11134469
Blood. 2001 Jul 15;98(2):398-404
11435309
AIDS. 2003 Sep 26;17(14):2053-61
14502008
Blood. 2000 Dec 1;96(12):3866-71
11090071
Pediatr Res. 2001 Feb;49(2):148-54
11158506
East Afr Med J. 1995 Jan;72(1):19-24
7781549
Clin Immunol. 2008 Jun;127(3):340-7
18356112
Braz J Med Biol Res. 2008 Aug;41(8):700-8
18797705
J Infect Dis. 2006 Oct 15;194(8):1089-97
16991083
J Acquir Immune Defic Syndr. 2003 Dec 15;34(5):482-90
14657758
J Acquir Immune Defic Syndr. 2006 Aug 15;42(5):545-53
16837862
East Afr Med J. 1995 Jan;72(1):10-4
7781547
Br J Clin Pharmacol. 2008 Aug;66(2):179-95
18537960
Vaccine. 2003 Jul 28;21(24):3352-7
12850338
Curr Opin Hematol. 2008 Jan;15(1):59-63
18043247
Physiol Rev. 1997 Jul;77(3):805-36
9234966
Clin Diagn Lab Immunol. 1995 Mar;2(2):233-5
7697535
AIDS. 2005 Jul 1;19(10):1071-9
15958839
Vaccine. 2003 Jul 28;21(24):3365-9
12850341
Acta Paediatr. 2005 Nov;94(11):1571-7
16303696
Clin Diagn Lab Immunol. 2004 Jan;11(1):29-34
14715541
Clin Infect Dis. 2005 Dec 1;41(11):1654-61
16267740
AIDS. 2008 Aug 20;22(13):1633-40
18670224
AIDS Res Hum Retroviruses. 2009 Oct;25(10):1049-53
19795988
Nat Immunol. 2008 Jul;9(7):733-42
18516038
Dev Immunol. 2002 Mar;9(1):9-17
12353663
Braz J Infect Dis. 2007 Dec;11(6):544-8
18327464
J Infect Dis. 2004 Aug 15;190(4):826-34
15272412