Photodynamic therapy enhancement of anti-tumor immunity.
Photodynamic therapy (PDT) is an FDA-approved modality for the treatment of early-stage disease and palliation of late-stage disease. Pre-clinical studies using mouse models and clinical studies in patients have demonstrated that PDT is capable of influencing the immune system. The effect of PDT on the generation of anti-tumor immunity is regimen-dependent and is tightly linked to the degree and nature of inflammation induced by PDT. However, the precise mechanism underlying PDT-regulated adaptive anti-tumor immunity remains unclear. This review will focus on the current knowledge of immune regulation by PDT.
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Craig M
CM
Brackett
Sandra O
SO
Gollnick
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology; D010778:Photochemotherapy
D016207:Cytokines
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