Mechanisms of protective effect of Dicarbamin on the blood system in cytostatic treatment.
The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early terms after cytostatic treatment and more active maturation of neutrophils in the bone marrow due to enhanced secretion of humoral factors by elements of hemopoietic environment at late terms of the experiment.
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
V E
VE
Nebolsin
V V
VV
Zhdanov
G N
GN
Zyuzkov
E V
EV
Udut
T Yu
TY
Khrichkova
E V
EV
Simanina
L A
LA
Stavrova
L A
LA
Miroshnichenko
A V
AV
Chaikovskiy
A M
AM
Dygai
D000818:Animals; D002208:Caproates; D003520:Cyclophosphamide / Q000494:pharmacology; D054697:Cytostatic Agents / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D020011:Protective Agents / Q000494:pharmacology*; D018709:Statistics, Nonparametric
D002208:Caproates; D054697:Cytostatic Agents; D007093:Imidazoles; D020011:Protective Agents; C539419:pentanedioic acid imidazolyl ethanamide; D003520:Cyclophosphamide