Intranasal vasopressin affects pair bonding and peripheral gene expression in male Callicebus cupreus.
Arginine vasopressin (AVP) is a neuropeptide hormone and neurotransmitter that has peripheral functions in water regulation, and central functions in the stress response and social bonding in male rodents. In this study, we investigated the role of AVP in partner preference behavior in a monogamous primate, the coppery titi monkey (Callicebus cupreus). Seven titi males each received three intranasal treatments: saline, low AVP (40 IU) and high AVP (80 IU) in random order, 1 week apart. They experienced a series of stimulus exposures to their female partner, a female stranger and an empty cage. Males were more likely to contact the stimulus and do so faster when either female stimulus was present. When pretreated with saline, males contacted the stranger more frequently than their partner; when pretreated with the high dosage of AVP, males contacted their partner more frequently than the stranger. We used microarray to measure peripheral changes in gene expression associated with intranasal AVP and found reduced expression of several genes coding for proinflammatory cytokines. The data presented here suggest that intranasally administered AVP has both central influences on social behavior and peripheral influences on inflammation in a nonhuman primate.
Psychology Department, University of California Davis, Davis, CA 95616, USA. mrjarcho@ucdavis.edu
M R
MR
Jarcho
S P
SP
Mendoza
W A
WA
Mason
X
X
Yang
K L
KL
Bales
D000281:Administration, Intranasal; D000818:Animals; D001923:Brain Chemistry / Q000235:genetics / Q000502:physiology*; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D010152:Pair Bond; D053820:Pitheciidae / Q000235:genetics / Q000502:physiology*; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000502:physiology*; D012919:Social Behavior; D014667:Vasopressins / Q000008:administration & dosage / Q000502:physiology*
D014667:Vasopressins
J Endocrinol. 1982 Jun;93(3):295-303
7086324
Peptides. 1982 Mar-Apr;3(2):111-3
6285317
Acta Endocrinol (Copenh). 1969 Jul;61(3):425-31
5820054
J Neuroendocrinol. 2004 Apr;16(4):325-32
15089970
J Appl Physiol (1985). 2007 Nov;103(5):1744-51
17823296
Nat Med. 2008 Jan;14(1):14-6
18180711
Physiol Behav. 1986;38(6):795-801
3823197
Physiol Behav. 2003 Aug;79(3):399-407
12954434
Psychoneuroendocrinology. 2005 Oct;30(9):924-9
15946803
Peptides. 2004 Sep;25(9):1565-74
15374658
Physiol Behav. 1994 Oct;56(4):751-8
7800744
Neurosci Biobehav Rev. 1996 Autumn;20(3):341-58
8880728
J Immunol. 1997 Jun 15;158(12):5589-95
9190905
Endocr Rev. 2000 Feb;21(1):55-89
10696570
Clin Diagn Lab Immunol. 2000 Sep;7(5):769-73
10973452
Horm Behav. 2010 Feb;57(2):255-62
20025881
Am J Physiol. 1962 Dec;203:1179-81
13976869
Nature. 1982 Sep 23;299(5881):355-7
6287293
Neuroscience. 2004;125(1):35-45
15051143
J Exp Med. 2007 Nov 26;204(12):2837-52
17967904
Cytokine Growth Factor Rev. 1999 Mar;10(1):41-60
10379911
Immunol Today. 2000 Jun;21(6):273-80
10825739
J Immunol. 1998 Mar 1;160(5):2231-7
9498762
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7744-8
7644488
Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6370-5
11959912
J Immunol. 1977 Jun;118(6):1977-81
301151
Nat Neurosci. 2004 Oct;7(10):1048-54
15452576
Am J Physiol. 1995 Feb;268(2 Pt 1):C331-8
7864072
J Clin Endocrinol Metab. 1993 Jun;76(6):1505-10
8501158
Endocrinology. 1992 Jul;131(1):153-8
1611995
J Clin Invest. 2004 Jan;113(2):302-9
14722621
Physiol Behav. 1995 Feb;57(2):331-8
7716212
Science. 1998 Dec 18;282(5397):2258-61
9856949
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11980-4
8876248
Psychoneuroendocrinology. 2002 Aug;27(6):705-14
12084663
J Neuroendocrinol. 2003 Nov;15(11):1070-4
14622437
Ann N Y Acad Sci. 2006 Jun;1069:62-76
16855135
J Neurosci. 1995 Jun;15(6):4250-8
7790909
Horm Behav. 1999 Aug;36(1):25-38
10433884
Neuropsychopharmacology. 2004 Mar;29(3):483-93
14647484
Brain Behav Immun. 1999 Mar;13(1):61-72
10371678
Br J Rheumatol. 1998 Feb;37(2):131-6
9569066
Am J Primatol. 1997;43(3):225-37
9359966
Endocrinology. 2007 Feb;148(2):849-56
17122081
Behav Neurosci. 1995 Aug;109(4):782-9
7576222
Proc Assoc Am Physicians. 1996 Sep;108(5):374-81
8902882
Psychoneuroendocrinology. 1986;11(2):131-9
3018820
Brain Res. 1988 Aug 2;457(1):143-7
3167559
J Neuroendocrinol. 2000 Feb;12(2):111-20
10718906
Physiol Behav. 1994 Jan;55(1):145-9
8140159
Nat Neurosci. 2002 Jun;5(6):514-6
11992114
Rev Reprod. 1997 Jan;2(1):28-37
9414463
J Comp Physiol Psychol. 1968 Jun;65(3):447-52
5691208
Psychol Bull. 1996 May;119(3):488-531
8668748
Rev Reprod. 1999 Sep;4(3):168-78
10521154
Biol Psychiatry. 2002 Jan 1;51(1):18-26
11801228
Nature. 1993 Oct 7;365(6446):545-8
8413608
Psychopharmacol Bull. 1993;29(3):409-14
8121969
Neuron. 2005 Aug 18;47(4):503-13
16102534
Endocrinology. 1998 Jul;139(7):3220-6
9645696
Horm Behav. 1992 Sep;26(3):339-49
1398553