Pregnancy in inherited hypokalemic salt-losing renal tubular disorder.
BACKGROUND
The management of inherited hypokalemia has improved and the issue of pregnancy has become important.


METHODS
Between 1992 and 2010, five Italian women with the clinical diagnosis of Gitelman syndrome gave birth to a total of six newborns. Pregnancy was uneventful in four women but was complicated by tiredness and tetanic seizures in the fifth woman. Drug management included potassium chloride in four cases and magnesium and amiloride in one case each. The six neonates were born at term (n=4) or near term (n=2), with a body weight that was appropriate for gestational age. The children, aged between 6 weeks and 18 years, were healthy and neurodevelopmentally and somatically normal at the last follow-up.


CONCLUSIONS
Women with hypokalemia can become pregnant and the disorder may be managed without negative effect on the fetus.
From the Division of Pediatrics, Mandic Hospital, Merate, Italy; Pediatric Nephrology, University of Bern, Bern, Switzerland; the Department of Mother-Child Sciences, University of Milan, Milan, Italy; the Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; and the Division of Pediatrics, Hospitals Mendrisio and Bellinzona, Switzerland.
Laura
L
Mascetti
Alberto
A
Bettinelli
Giacomo D
GD
Simonetti
Alessandro
A
Tagliabue
Marie Lousie
ML
Syrén
Francesco
F
Nordio
Mario G
MG
Bianchetti
D000328:Adult; D000584:Amiloride / Q000627:therapeutic use; D001477:Bartter Syndrome / Q000175:diagnosis; D005260:Female; D053579:Gitelman Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007008:Hypokalemia / Q000188:drug therapy* / Q000503:physiopathology; D007231:Infant, Newborn; D008274:Magnesium / Q000627:therapeutic use; D008297:Male; D011189:Potassium Chloride / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000503:physiopathology; D011256:Pregnancy Outcome; D012640:Seizures / Q000175:diagnosis / Q000209:etiology; D013746:Tetany / Q000175:diagnosis / Q000209:etiology; D016896:Treatment Outcome
D011189:Potassium Chloride; D000584:Amiloride; D008274:Magnesium
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