Phragmalin- and mexicanolide-type limonoids from the leaves of Trichilia connaroides.
Phytochemical investigation of the leaves of Trichilia connaroides afforded 12 new limonoids with phragmalin- (1-11) and mexicanolide-type skeletons (12). The structures of these limonoids, including the absolute configuration of 3, were determined by spectroscopic analysis. Compounds 6 and 8 showed moderate cytotoxicity against HL-60 cells.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Qiang
Q
Zhang
Ying-Tong
YT
Di
Hong-Ping
HP
He
Xin
X
Fang
Dong-Lin
DL
Chen
Xiao-Hui
XH
Yan
Feng
F
Zhu
Ting-Quan
TQ
Yang
Ling-Li
LL
Liu
Xiao-Jiang
XJ
Hao
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
C557392:15-acetyltrichagmalin E; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036701:Limonins; C557391:trichagmalin D