Simultaneous estimation of Cefixime and Erdosteine in capsule dosage form by spectrophotometric method.
Two accurate, precise, rapid and economical methods viz. Absorption correction method and Dual wavelength method were developed for the estimation of Cefixime (CEF) and Erdosteine (ERDO) in capsule dosage form. In both the methods linearity was observed in the concentration range of 2-25 microg/ml for Cefixime and 3-37.5 microg/ml for Erdosteine. The results of the analysis have been validated statistically and by recovery studies. The percentage assay was found to be 100.03 +/- 0.68 for Cefixime and 99.5 +/- 1.0 for Erdosteine (Mean +/- S.D) by method A and 99.54 +/- 0.84 for Cefixime and 100.54 +/- 1.3 for Erdosteine (Mean +/- S.D) by method B respectively.
Department of Quality Assurance, A.I.S.S.M.S. College of Pharmacy, Pune-411 001. madhura1777@yahoo.com
Madhura V
MV
Dhoka
Vandana T
VT
Gawande
Pranav P
PP
Joshi
Santosh V
SV
Gandhi
Neelam G
NG
Patil
D000900:Anti-Bacterial Agents / Q000032:analysis*; D002214:Capsules; D020682:Cefixime / Q000032:analysis*; D005100:Expectorants / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D013864:Thioglycolates / Q000032:analysis*; D013876:Thiophenes / Q000032:analysis*
D000900:Anti-Bacterial Agents; D002214:Capsules; D005100:Expectorants; D013864:Thioglycolates; D013876:Thiophenes; C048498:erdosteine; D020682:Cefixime