Genetic regulation of endothelin-1 in vascular endothelial cells.
Endothelin-1 (ET-1) is a potent vasoconstrictor and smooth muscle cell mitogen synthesized and secreted by endothelial cells. This vasoactive peptide is genetically regulated by many of the cytokines, hormones, and physical forces that are involved in vascular disease processes. Transcriptional regulation of the ET-1 gene depends upon the cis-acting elements of the ET-1 promoter and their interaction with the protooncogene products Fos and Jun as well as other DNA-binding proteins.
Cardiovascular Institute, Boston University, Boston, MA 02118 USA.
R J
RJ
Hilkert
M E
ME
Lee
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Quertermous