Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.
Classical genetic approaches for studying bacterial pathogenesis have provided a solid foundation for our current understanding of microbial physiology and the interactions between pathogen and host. During the past decade however, advances in several arenas have expanded the ways in which the biology of pathogens can be studied. This review discussed the impact of these advances on bacterial genetics, including the application of genomics and chemical biology to the study of pathogenesis.
The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
James E
JE
Gomez
Anne
A
Clatworthy
Deborah T
DT
Hung
D000818:Animals; D001419:Bacteria / Q000737:chemistry / Q000235:genetics* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D023281:Genomics / Q000639:trends; D054884:Host-Pathogen Interactions; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D054852:Small Molecule Libraries; D037521:Virulence Factors / Q000235:genetics
D054852:Small Molecule Libraries; D037521:Virulence Factors