Epley's manoeuvre versus Epley's manoeuvre plus labyrinthine sedative as management of benign paroxysmal positional vertigo: prospective, randomised study.
BACKGROUND
We report a prospective, randomised study of 51 patients with benign paroxysmal positional vertigo treated with Epley's manoeuvre alone or Epley's manoeuvre plus labyrinthine sedative, at Sundaram Medical Foundation, Chennai, India.


OBJECTIVE
To compare the efficacy of Epley's manoeuvre versus Epley's manoeuvre plus labyrinthine sedative in the treatment of benign paroxysmal positional vertigo.


METHODS
Consecutive patients were selected based on history and positive Dix-Hallpike test. Patients were randomised to receive either Epley's manoeuvre alone or Epley's manoeuvre plus labyrinthine sedative for one week. Both groups were followed up for four weeks.


RESULTS
Univariate analysis showed that one- and four-week outcomes were influenced by the number of episodes, symptom duration and treatment type. Multivariate logistic regression analysis showed that the one-week outcome was significantly influenced by symptom duration and treatment type, while the four-week outcome was significantly influenced by symptom duration alone. Patients receiving Epley's manoeuvre alone showed better recovery than those receiving both Epley's manoeuvre and labyrinthine sedative.


CONCLUSIONS
Labyrinthine sedatives do not aid recovery from benign paroxysmal positional vertigo when used in addition to Epley's manoeuvre.
Department of Otolaryngology, Sundaram Medical Foundation, Chennai, India.
I
I
Sundararajan
V
V
Rangachari
V
V
Sumathi
K
K
Kumar
D000328:Adult; D000368:Aged; D065635:Benign Paroxysmal Positional Vertigo; D002936:Cinnarizine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D056888:Patient Positioning / Q000379:methods*; D011446:Prospective Studies; D012044:Regression Analysis; D016896:Treatment Outcome; D014717:Vertigo / Q000188:drug therapy / Q000628:therapy*
D006634:Histamine H1 Antagonists; D002936:Cinnarizine