[Pharmacological correction of the cytogenetic effects of cisplatin].
Beginning with the first hours of experiments, cisplatin evoked an increase of chromosomal aberrations in CBA/CaLac bone marrow cells. Significant increase of structural infringements of chromosomes due to chromatid breaks was revealed in metaphase plates of murine bone marrow preparations through 24 h after cisplatin intraperitoneal introduction. In late terms of research (90th day), the high level of aberrations of chromosomes was retained. The most pronounced correction of cisplatin mutagenicity was achieved using a preliminary course of thiophan introduction.
O L
OL
Voronova
O V
OV
Neupokoeva
E P
EP
Fedorova
A E
AE
Prosenko
A A
AA
Churin
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000139:chemically induced* / Q000187:drug effects*; D002945:Cisplatin / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009153:Mutagens / Q000009:adverse effects / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology*; D013997:Time Factors
D009153:Mutagens; D013876:Thiophenes; C045141:thiophane; D002945:Cisplatin