Viral decay rates are similar in HIV-infected patients with and without TB coinfection during treatment with an Efavirenz-based regimen.
Viral decay rates during efavirenz-based therapy were compared between human immunodeficiency virus (HIV)-infected patients without tuberculosis (n = 40) and those with tuberculosis coinfection who were receiving concurrent antituberculous therapy (n = 34). Phase I and II viral decay rates were similar in the 2 groups (P > .05). Overall, concurrent antituberculous therapy did not reduce the efficacy of the HIV treatment.
University of Ghana Medical School, Ghana.
Margaret
M
Lartey
Kwamena W
KW
Sagoe
Hongmei
H
Yang
Ernest
E
Kenu
Fafa
F
Xexemeku
Joseph
J
Oliver-Commey
Vincent
V
Boima
Markafui
M
Seshie
Augustine
A
Sagoe
Julius A A
JA
Mingle
Timothy P
TP
Flanigan
Hulin
H
Wu
Awewura
A
Kwara
D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D000995:Antitubercular Agents / Q000008:administration & dosage; D048588:Benzoxazines / Q000008:administration & dosage*; D003521:Cyclopropanes; D005260:Female; D006678:HIV / Q000302:isolation & purification*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D014376:Tuberculosis / Q000150:complications; D019562:Viral Load; D014766:Viremia
D000480:Alkynes; D019380:Anti-HIV Agents; D000995:Antitubercular Agents; D048588:Benzoxazines; D003521:Cyclopropanes; C098320:efavirenz
J Infect Dis. 2004 Feb 15;189(4):593-601
14767811
AIDS. 2009 Aug 24;23(13):1717-25
19461502
Nature. 1995 Jan 12;373(6510):123-6
7816094
AIDS. 1998 Jul 30;12(11):F111-5
9708400
Lancet. 2001 Nov 24;358(9295):1760-5
11734232
J Infect Dis. 2007 Apr 15;195(8):1169-76
17357053
Br J Clin Pharmacol. 2009 Apr;67(4):427-36
19371316
J Med Virol. 2005 Feb;75(2):202-8
15602734
J Acquir Immune Defic Syndr. 2006 Sep;43(1):42-6
16885778
J Infect Dis. 2003 Jun 15;187(12):1967-71
12792875
AIDS. 2006 Aug 1;20(12):1605-12
16868441
J Infect Dis. 2004 Nov 1;190(9):1670-6
15478074
AIDS. 2003 Dec 5;17(18):2615-22
14685055
Biostatistics. 2001 Mar;2(1):13-29
12933554
J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):148-52
19131895
Clin Chest Med. 2005 Jun;26(2):283-94, vi-vii
15837111
J Acquir Immune Defic Syndr. 2009 Apr 15;50(5):439-43
19223781
N Engl J Med. 2010 Feb 25;362(8):697-706
20181971
Biometrics. 1999 Jun;55(2):410-8
11318194
J Infect Dis. 1999 Apr;179(4):799-807
10068574
Ther Drug Monit. 2006 Aug;28(4):517-25
16885719
J Infect Dis. 2003 Mar 15;187(6):896-900
12660935
J Antimicrob Chemother. 2006 Dec;58(6):1299-302
17032686
J Infect Dis. 2006 May 15;193(10):1437-40
16619192
AIDS. 1999 Feb 25;13(3):429-30
10199240