Long-term exposure to airborne particles and arterial stiffness: the Multi-Ethnic Study of Atherosclerosis (MESA).
BACKGROUND
Increased arterial stiffness could represent an intermediate subclinical outcome in the mechanistic pathway underlying associations between average long-term pollution exposure and cardiovascular events.


OBJECTIVE
We hypothesized that 20 years of exposure to particulate matter (PM) ≤ 2.5 and 10 μm in aerodynamic diameter (PM2.5 and PM10, respectively) would be positively associated with arterial stiffness in 3,996 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who were seen at six U.S. study sites.


METHODS
We assigned pollution exposure during two decades preceding a clinical exam (2000-2002) using observed PM10 from monitors nearest participants' residences and PM10 and PM2.5 imputed from a space-time model. We examined three log-transformed arterial stiffness outcome measures: Young's modulus (YM) from carotid artery ultrasound and large (C1) and small (C2) artery vessel compliance from the radial artery pulse wave. All associations are expressed per 10 μg/m3 increment in PM and were adjusted for weather, age, sex, race, glucose, triglycerides, diabetes, waist:hip ratio, seated mean arterial pressure, smoking status, pack-years, cigarettes per day, environmental tobacco smoke, and physical activity. C1 and C2 models were further adjusted for heart rate, weight, and height.


RESULTS
Long-term average particle exposure was not associated with greater arterial stiffness measured by YM, C1, or C2, and the few associations observed were not robust across metrics and adjustment schemes.


CONCLUSIONS
Long-term particle mass exposure did not appear to be associated with greater arterial stiffness in this study sample.
University of Michigan School of Public Health, Ann Arbor, Michigan 48109-2029, USA. marieo@umich.edu
Marie S
MS
O'Neill
Ana V
AV
Diez-Roux
Amy H
AH
Auchincloss
Mingwu
M
Shen
João A
JA
Lima
Joseph F
JF
Polak
R Graham
RG
Barr
Joel
J
Kaufman
David R
DR
Jacobs
D000368:Aged; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D050197:Atherosclerosis / Q000139:chemically induced* / Q000453:epidemiology*; D015331:Cohort Studies; D004781:Environmental Exposure; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D052638:Particulate Matter / Q000032:analysis / Q000633:toxicity*; D014481:United States / Q000453:epidemiology; D014504:Urban Health
D000393:Air Pollutants; D052638:Particulate Matter
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