Multiple facets of nuclear periphery in gene expression control.
Nuclear pore complexes play a central role in controlling the traffic between the nucleus and the cytoplasm. Progress during the last decade has highlighted nuclear periphery components as novel players in chromatin organization, gene regulation, and genome stability. For instance, lamins associate with repressive chromatin while nuclear pores tend to associate with active chromatin. Interestingly, nucleoporins (Nups) act not only at the nuclear periphery but also in the nucleoplasm. Here we provide an overview of the latest findings and discuss the functional importance of nucleoporin association with specific genes, their role in transcriptional memory, the coupling of transcription and mRNA export, and genome integrity.
Max-Planck-Institute of Immunobiology und Epigenetics, Stübeweg 51,79108 Freiburg im Breisgau, Germany.
Ghislaine
G
Arib
Asifa
A
Akhtar
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D005786:Gene Expression Regulation; D042822:Genomic Instability; D006801:Humans; D022022:Nuclear Pore / Q000235:genetics / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism
D002843:Chromatin; D028861:Nuclear Pore Complex Proteins