Microvesicles at the crossroads between infection and cardiovascular diseases.
Observational and experimental studies continue to support the association of infection and infection-stimulated inflammation with development of cardiovascular disease (CVD) including atherosclerosis and thrombosis. Microvesicles (MV) are heterogeneous populations of sealed membrane-derived vesicles shed into circulation by activated mammalian cells and/or pathogenic microbes that may represent an interface between bacterial/microbial infection and increased risk of CVD. This review evaluates how MV act to modulate and intersect immunological and inflammatory responses to infection with particular attention to progression of CVD. Although infection-related stimuli provoke release of MV from blood and vascular cells, MV express phosphatidylserine and other procoagulant factors on their surface, which initiate and amplify blood coagulation. In addition, MV mediate cell-cell adhesion, which may stimulate production of pro-inflammatory cytokines in vascular cells, which in turn aggravate progression of CVD and propagate atherothrombosis. MV transfer membrane receptors, RNA and proteins among cells, and present auto-antigens from their cells of origin to proximal or remote target cells. Because MV harbor cell surface proteins and contain cytoplasmic components of the parent cell, they mediate biological messages and play a pivotal role in the crossroad between infection-stimulated inflammation and CVDs.
Department of Physiology, China Pharmaceutical University, Nanjing, Jiangsu, China.
Jing
J
Xiong
Virginia M
VM
Miller
Yunman
Y
Li
Muthuvel
M
Jayachandran
D000818:Animals; D001424:Bacterial Infections / Q000150:complications / Q000382:microbiology; D002318:Cardiovascular Diseases / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007239:Infections / Q000150:complications / Q000382:microbiology; D007249:Inflammation / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D012307:Risk Factors
J Immunol. 1998 Oct 15;161(8):4382-7
9780216
PLoS One. 2009;4(5):e5421
19412552
Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):430-5
17158353
Neth J Med. 2009 Jul-Aug;67(7):266-73
19687520
Circulation. 2001 Nov 27;104(22):2649-52
11723013
Acta Anaesthesiol Scand. 1998 May;42(5):551-7
9605371
J Am Coll Cardiol. 2005 May 3;45(9):1472-3
15862421
Arterioscler Thromb Vasc Biol. 2004 May;24(5):816-23
14976002
Gastroenterology. 1996 Jun;110(6):1897-904
8964416
Am J Pathol. 2008 Oct;173(4):1210-9
18772329
Antioxid Redox Signal. 2004 Aug;6(4):765-76
15242558
J Am Coll Cardiol. 2000 Dec;36(7):2081-9
11127444
J Biol Chem. 1992 Jul 25;267(21):15168-75
1321830
J Biol Chem. 1991 Sep 15;266(26):17261-8
1654328
J Biol Chem. 1993 Jul 15;268(20):14586-9
8325838
Ann Agric Environ Med. 2008;15(1):153-61
18581995
Platelets. 1998;9(2):115-9
16793686
Curr Opin Hematol. 2004 May;11(3):156-64
15257014
Biochim Biophys Acta. 2008 Oct;1778(10):2388-94
18621018
J Biol Chem. 2000 Apr 14;275(15):11058-63
10753909
Circulation. 2005 Jun 28;111(25):3481-8
15983262
Appl Environ Microbiol. 2000 Oct;66(10):4414-20
11010892
Blood. 2000 Feb 1;95(3):930-5
10648405
Rev Esp Enferm Dig. 2010 Jan;102(1):41-50
20187683
Blood. 2000 Jul 1;96(1):170-5
10891447
Platelets. 2008 Mar;19(2):96-103
18297548
Trends Cell Biol. 2009 Feb;19(2):43-51
19144520
Semin Hematol. 2008 Apr;45(2 Suppl 1):S16-20
18544418
Br J Haematol. 2008 Apr;141(1):84-91
18279456
Thromb Haemost. 2001 May;85(5):810-20
11372673
Gend Med. 2008;5 Suppl A:S91-S102
18395686
J Appl Physiol (1985). 2007 Jan;102(1):429-33
16916914
Clin Sci (Lond). 2008 Apr;114(8):509-31
18336368
J Cardiovasc Pharmacol. 2009 Jul;54(1):57-62
19528814
N Engl J Med. 2003 May 15;348(20):1986-94
12682352
Microb Drug Resist. 1996 Spring;2(1):1-8
9158716
Blood Rev. 2007 May;21(3):157-71
17118501
Med Sci Monit. 2009 Oct;15(10):RA209-219
19789524
Acta Biomater. 2011 Mar;7(3):1339-45
21029794
Bratisl Lek Listy. 2008;109(8):333-40
18837239
Nanomedicine (Lond). 2009 Dec;4(8):931-41
19958229
Thromb Res. 2003 Feb 15;109(4):175-80
12757771
Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1417-20
10845851
N Engl J Med. 2004 Dec 16;351(25):2611-8
15602021
J Clin Invest. 1998 Jul 1;102(1):136-44
9649567
Surgery. 2010 Feb;147(2):181-4
19767047
Blood. 2005 Sep 1;106(5):1604-11
15741221
Blood. 2000 Feb 15;95(4):1317-23
10666205
Blood. 2002 Jun 1;99(11):3962-70
12010795
Microbiol Mol Biol Rev. 2010 Mar;74(1):81-94
20197500
Arthritis Rheum. 2005 Nov;52(11):3337-48
16255015
Clin Exp Immunol. 2011 Jan;163(1):26-32
21039423
Korean J Physiol Pharmacol. 2009 Dec;13(6):475-82
20054495
Thromb Res. 1999 Dec 1;96(5):391-7
10605954
Haematologica. 2009 Nov;94(11):1502-12
19648164
J Immunol. 1994 Oct 1;153(7):3245-55
7522256
Curr Drug Targets. 2007 Apr;8(4):493-500
17430119
Infect Immun. 1993 Nov;61(11):4933-6
8406899
Blood. 1991 Dec 1;78(11):2880-6
1659468
Oral Microbiol Immunol. 2000 Dec;15(6):393-6
11154438
Blood. 2006 Sep 15;108(6):1868-76
16720831
J Endod. 2009 May;35(5):626-30
19410072
Stroke. 2002 Nov;33(11):2581-6
12411646
Circ Cardiovasc Qual Outcomes. 2009 Mar;2(2):108-15
20031822
J Periodontol. 2008 Aug;79(8 Suppl):1544-51
18673009
Circulation. 2001 Feb 27;103(8):1064-70
11222467
J Thromb Haemost. 2006 Jun;4(6):1296-302
16706974
Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):665-71
20399083
Microbiology (Reading). 1999 Aug;145 ( Pt 8):2051-2060
10463171
J Thromb Haemost. 2009 Jul;7(7):1092-8
19422446
Blood. 2005 Feb 15;105(4):1734-41
15494427
J Am Soc Nephrol. 2005 Nov;16(11):3381-8
16192427
Platelets. 2005 Nov;16(7):408-14
16236602
Blood. 2008 May 15;111(10):5028-36
18198347
J Biol Chem. 2007 Oct 12;282(41):29977-86
17644516
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2311-5
10051638
Thromb Haemost. 2007 Oct;98(4):831-7
17938808
Appl Environ Microbiol. 2010 Jun;76(11):3732-9
20382806
PLoS One. 2009 Sep 11;4(9):e6990
19750223
Crit Rev Oncol Hematol. 1999 Apr;30(2):111-42
10439058
Trends Mol Med. 2004 Apr;10(4):171-8
15059608
Mayo Clin Proc. 2001 Nov;76(11):1102-10
11702898
Proteomics. 2008 Jun;8(12):2430-46
18563738
Thromb Res. 2010 Nov;126(5):414-7
19482340
FASEB J. 2003 Mar;17(3):476-8
12514112
Blood. 2007 Jun 15;109(12):5242-50
17347408
Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2594-604
16990554
Acta Biomed. 2010;81 Suppl 1:73-6
20518194
J Am Coll Cardiol. 2009 Dec 15;54(25):2374-5
20082926
J Invest Dermatol. 2004 Mar;122(3):830-6
15086572
Circulation. 2001 Jan 2;103(1):45-51
11136684
Cardiovasc Res. 2003 Oct 15;60(1):58-67
14522407
J Exp Med. 2003 Jun 2;197(11):1585-98
12782720
Age (Dordr). 2010 Mar;32(1):109-21
19908165
J Leukoc Biol. 2010 Jun;87(6):1115-23
20335312
Nutr Metab (Lond). 2010 Jul 06;7:55
20604917
Nature. 2002 Dec 19-26;420(6917):868-74
12490960
Circulation. 1999 Jan 26;99(3):348-53
9918520
Oxid Med Cell Longev. 2009 Jan-Mar;2(1):2-6
20046638
PLoS One. 2009 Nov 30;4(11):e8058
19956594
Blood. 2005 Apr 1;105(7):2764-70
15604222
Can J Vet Res. 2006 Jan;70(1):43-9
16548331
Curr Vasc Pharmacol. 2007 Jan;5(1):15-25
17266610
J Biol Chem. 2003 Aug 29;278(35):33161-8
12810708
Am Heart J. 2006 Jun;151(6):1215-22
16781222
Cell Microbiol. 2011 Jan;13(1):1-9
21040357
Int J Mol Med. 2007 May;19(5):783-90
17390084
Thromb Haemost. 2007 Nov;98(5):1096-107
18000616
Climacteric. 2009 Apr;12(2):177-84
19051075
Pflugers Arch. 2010 May;459(6):923-39
20306272
J Immunol. 2009 Jul 1;183(1):533-42
19542464
Int J Immunopathol Pharmacol. 2003 Sep-Dec;16(3):225-31
14611725
Ann Agric Environ Med. 2005;12(2):289-94
16457487
Proteomics Clin Appl. 2008 Jun;2(6):882-91
21136886
Recent Pat Cardiovasc Drug Discov. 2007 Jan;2(1):41-51
18221102
Blood. 2010 Aug 5;116(5):854-5
20688968
N Engl J Med. 2002 Jul 18;347(3):185-92
12124407
Circulation. 2004 Apr 6;109(13):1653-9
15023873
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H931-H938
18621859
Circulation. 2000 Feb 29;101(8):841-3
10694520
J Trauma. 2004 Apr;56(4):823-30; discussion 830-1
15187749
Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1677-83
12842841
Anal Biochem. 2002 Mar 15;302(2):191-8
11878797
Toxicology. 2000 Nov 30;155(1-3):55-61
11154797
Platelets. 2002 Feb;13(1):21-30
11918833
Proc Natl Acad Sci U S A. 1990 Sep;87(18):6995-9
2119499
Circulation. 2001 Oct 30;104(18):2182-7
11684628
Microbiology (Reading). 2004 Jul;150(Pt 7):2161-2169
15256559
Transfus Med Rev. 2006 Jan;20(1):1-26
16373184
Neurosci Lett. 2010 Jul 5;478(2):93-6
20451579
J Thromb Haemost. 2010 Jun;8(6):1403-9
20345726
Int J Cardiol. 2004 Dec;97(3):439-46
15561331
Arthritis Rheum. 2004 Mar;50(3):927-36
15022336
Immunity. 2001 Nov;15(5):825-35
11728343
Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1004-9
15706036
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2522-7
16210570
Appl Environ Microbiol. 1999 May;65(5):1843-8
10223967
PLoS Pathog. 2010 Jan 15;6(1):e1000724
20090836
Blood. 1997 Nov 1;90(9):3245-87
9345009
Proteomics. 2006 Jan;6(1):153-71
16342139