Periodontal disease and bacterial vaginosis as genetic and environmental markers for the risk of spontaneous preterm labor and preterm birth.
OBJECTIVE
The aim of this study was to review the evidence associating periodontal disease, and bacterial vaginosis with preterm birth, and the link with gene polymorphism, as well as the preventions and interventions which might reduce the risk of spontaneous preterm labor and preterm births in women with periodontal disease and/or bacterial vaginosis.


BACKGROUND
Preterm birth accounts for 70% of perinatal mortality, nearly 50% of long term neurological morbidity, and a significant impact on health care costs. There is evidence that spontaneous preterm labor and preterm birth are associated with intrauterine infection due to abnormal genital and/or oral colonization. Periodontal disease and bacterial vaginosis share microbiological similarities, and both conditions are associated with spontaneous preterm labor and preterm birth. In addition, periodontal disease and bacterial vaginosis have been linked through gene polymorphism.


METHODS
A review of the literature using widely accepted scientific search engines in English language.


RESULTS
Studies evaluating antibiotic administration to eradicate periodontal disease and/or bacterial vaginosis responsible organisms, and minimize the risk of preterm births have yielded conflicting results. With respect to bacterial vaginosis, the timing and the choice of antibiotic administration might partly explain the conflicting results. The use of scaling and/or root planning for women with periodontal disease appears to reduce the risk of preterm birth, but routine administration of antibiotics has not demonstrated any impact on preterm birth.


CONCLUSIONS
Prospective studies evaluating the association of gene polymorphism with preterm birth, and the contribution of periodontal disease and bacterial vaginosis are needed.
Department of Obstetrics & Gynaecology, St Mary's Imperial NHS Trust, London, UK.
Olaleye
O
Sanu
Ronald F
RF
Lamont
D004198:Disease Susceptibility; D004777:Environment; D005260:Female; D005819:Genetic Markers / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007752:Obstetric Labor, Premature / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D010510:Periodontal Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000235:genetics; D047928:Premature Birth / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D011379:Prognosis; D012307:Risk Factors; D016585:Vaginosis, Bacterial / Q000150:complications* / Q000175:diagnosis / Q000235:genetics
D005819:Genetic Markers