[Dinitrosyl complexes of iron with glutathione in the rat myocardial tissue during regional ischemia and postischemic reperfusion].
The injection of dinitrosyliron iron complexes with glutathione at the onset of 40-min rat regional myocardial ischemia was shown to exert a clear cardioprotective action by decreasing the infarct size and suppressing the cardiac rhythm disturbance. After the introduction of the preparation, its effective accumulation with protein thiol-containing ligands in the myocardial tissue was registered be the EPR method. It was also found that, as a result of postischemic reperfusion, the rate of the decrease in the content of these complexes in the ischemic area increases, which demonstrates the effective scavenging of short-lived reactive oxygen species by molecules of dinitrosyl iron complexes.
A A
AA
Timoshin
O I
OI
Pisarenko
O V
OV
Tskitishvili
L I
LI
Serebriakova
I M
IM
Studneva
D Iu
DIu
Drobotova
E K
EK
Ruuge
A F
AF
Vanin
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D002560:Cerebrovascular Circulation; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D007501:Iron / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000517:prevention & control*; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*; D009589:Nitrogen Oxides / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014665:Vasodilator Agents / Q000378:metabolism / Q000627:therapeutic use*
D009589:Nitrogen Oxides; D014665:Vasodilator Agents; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione