Study of anti-ischemic effect of afobazole in experimental myocardial infarction.
Seven-day treatment of rats with experimental myocardial infarction with afobazole (5-ethoxy-2-[2-morpholino)-ethylthio] benzimidasole dihydrochloride) resulted in shrinkage of the ischemic damage area in the heart, stimulation of reparative processes in the myocardium, and prevention of postinfarction remodeling of the left ventricle. Anti-ischemic effect of afobazole in experimental myocardial infarction is presumably due to its interactions with σ(1) receptors.
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. SAK538@yandex.ru
S A
SA
Kryzhanovskyi
A V
AV
Sorokina
V N
VN
Stolyaruck
M B
MB
Vititnova
I A
IA
Miroshkina
I B
IB
Tsorin
A D
AD
Durnev
S B
SB
Seredenin
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D008297:Male; D009025:Morpholines / Q000494:pharmacology* / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017480:Receptors, sigma / Q000378:metabolism; D018709:Statistics, Nonparametric; D020257:Ventricular Remodeling / Q000187:drug effects*
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D017480:Receptors, sigma; C101491:sigma1-binding protein, rat