Social isolation improves working memory at reversal but not primary radial-arm maze learning in rats.
Social isolation starting from the 21st day of birth affected neither a short-term nor a long-term memory in male rats at primary acquisition learning in an 8-arm radial maze. A number of the short-term and long-term memory errors were substantially decreased during primary learning but the difference between groups was not significant. Isolates were faster to start a search in an individual trial and took less time to finish offa trial. During the reversal learning, when baited and non-baited arms were reversed, the isolates outperformed of socially reared rats on working but not reference memory task. In overall they made twice less working memory errors than socially reared animals. During the reversal learning the isolates were also faster than non-isolates in initiation and completion of a trial. Maternal separation of rat's pups on the postnatal days 1-21 for 4 hr per day did not affect either working or reference memory on both primary and reversal learning. The data obtained are discussed on basis of influence of stress in early postnatal life on hypothalamo-pituitary axis and its effects on behavior of adult animals.
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow. grigorygrigoryan@hotmail.com
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Grigoryan
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Weiss
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Feldon
D000818:Animals; D008297:Male; D008426:Maternal Deprivation; D018782:Maze Learning; D057567:Memory, Long-Term; D008570:Memory, Short-Term; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012934:Social Isolation