Incidence and clinical characteristics of clonal cytogenetic abnormalities of acquired aplastic anemia in adults.
BACKGROUND
Cytogenetic abnormalities (CAs) have been reported frequently in patients with otherwise typical aplastic anemia (AA), but their implications in the prognosis and in the evolution to hematologic malignancies are controversial.


METHODS
We retrospectively analyzed 127 adult AA patients who had successful cytogenetic analysis at initial diagnosis.


RESULTS
The patients were classified into 3 groups according to the initial and follow-up results of cytogenetic profiles. Group 1 included patients who had persistent AA with normal cytogenetic profiles (N=117); Group 2, those who had a normal cytogenetic profile at initial diagnosis but later acquired CA (N=4, 3.1%); and Group 3, those who had CA at the initial diagnosis, regardless of follow-up cytogenetic status (N=6,4.7%). In Group 2, 2 patients later developed CA without progression to acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS); the other 2 patients later progressed to AML. None of the patients in Group 3 progressed to AML or MDS. There was no significant difference in overall survival between Groups 1 and 3.


CONCLUSIONS
AA patients with CA at initial diagnosis or follow-up may not be at greater risk for evolution to AML or MDS, or show shorter survival periods. Prospective studies and a larger patient samples are needed to establish the clinical relevance of CA.
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Ji Hyun
JH
Lee
Kyung A
KA
Kwon
Suee
S
Lee
Sung Yong
SY
Oh
Sung-Hyun
SH
Kim
Hyuk-Chan
HC
Kwon
Jin-Yeong
JY
Han
Moo-Kon
MK
Song
Joo-Seop
JS
Chung
Ho Sup
HS
Lee
Yang Soo
YS
Kim
Sang-Min
SM
Lee
Young-Don
YD
Joo
Hyo-Jin
HJ
Kim
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