Effect of dinitrosyl iron complexes on platelet aggregation induced by HeLa cervical carcinoma cells.
We studied the effect of dinitrosyl iron complexes with glutathione ligands on platelet aggregation with HeLa tumor cells. It was shown that dinitrosyl iron complexes not only inhibited cell aggregation, but being added at early stages can also block this process. These findings dictate further studies of dinitrosyl iron complexes as a compound reducing metastasizing and thrombus-formation in tumor patients.
Byelorussian State University, Minsk, Russia. shamova@tut.by
E V
EV
Shamova
L M
LM
Shishlo
I V
IV
Gorudko
E N
EN
Aleksandrova
S N
SN
Cherenkevich
K B
KB
Shumaev
D005260:Female; D005978:Glutathione / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D008853:Microscopy; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism; D009589:Nitrogen Oxides / Q000378:metabolism / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
D009589:Nitrogen Oxides; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione