[Dynamic changes of hemorheology in rats after carbon monoxide poisoning].
OBJECTIVE
To investigate the startup detail of circulation dysfunction and its role in the progress of delayed neuropsychologic sequelae (DNS) after carbon monoxide (CO) poisoning with comparison with the model of ischemia-reperfusion.


METHODS
The ischemia-reperfusion rat model was established by Pulsinelli-Brierley method, and the CO poisoning rats model by i.p. injected with CO repeatedly respectively, and the rats were identified with DNS following the experiment of pathology and the ethnology.


RESULTS
The whole blood viscosity, plasma viscosity, hematocrit and fibrinogen increased significantly immediately after reperfusion, and recovered gradually with the ischemia-reperfusion rat model. The whole blood viscosity decreased significantly immediately after CO treated i.p. Especially at low shear rate, the hematocrit also declined remarkably in the early stage after CO treatment. But 1day later, these parameters turned to the trend of the ischemia-reperfusion rats. There was a prominent elevation of both indexes until the 14th day following CO injection i.p.


CONCLUSIONS
There are significantly sustained hyper-coagulation and hyper-viscosity with circulation in rats after CO poisoning compared with ischemia-reperfusion model during the period of DNS, which might contribute to increase cerebral circulation resistance, blocked blood flow, and deteriorate hypoxemia in progression of DNS.
Research Center of Occupational Medicine, The Third Hospital of Peking University, Beijing 100191, China.
Li
L
Guan
Zong-Yang
ZY
Li
Jin-Yuan
JY
Zhao
Xi-Xian
XX
Xu
Tao
T
Wen
Yan-Lin
YL
Zhang
D000818:Animals; D001775:Blood Circulation; D002249:Carbon Monoxide Poisoning / Q000503:physiopathology*; D004195:Disease Models, Animal; D018056:Hemorheology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000503:physiopathology