Proper regrafting of Ig-like transcript 2 after trogocytosis allows a functional cell-cell transfer of sensitivity.
The acquisition by T cells of exogenous ligands originally expressed by APC has been already described. However, reports essentially focused on the outward signaling of acquired ligands and their effects on surroundings cells. We investigated the function of transferred receptors (not ligands) on the T cells that acquired them (not on cells they interact with). We show that inhibitory Ig-like transcript 2 receptors efficiently transfer from monocytes to autologous T cells by trogocytosis and integrate within the plasma membrane of the acquirer T cells. Furthermore, the acquired receptors can access compatible signaling machinery within acquirer T cells and use it to signal and alter the functions of their new host cells. These data are a formal demonstration that a transferred molecule may send signals to its new host cell. We also provide evidence that sensitivity to modulatory molecules can be acquired from other cells and introduce the notion of intercellular transfer of sensitivities.
Commissariat a l'Energie Atomique, Institut d'Imagerie BioMedicale, Service de Recherches en Hemato-Immunologie, 75475 Paris, France.
Kiave-Yune
KY
HoWangYin
Julien
J
Caumartin
Benoit
B
Favier
Marina
M
Daouya
Layale
L
Yaghi
Edgardo D
ED
Carosella
Joel
J
LeMaoult
D015703:Antigens, CD / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology*; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D018920:Coculture Techniques; D006801:Humans; D007114:Immunization / Q000379:methods*; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology; D008561:Membrane Fusion / Q000276:immunology; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding / Q000276:immunology; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism
D015703:Antigens, CD; C105299:LILRB1 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008024:Ligands; D011971:Receptors, Immunologic