Water administration of the medium-chain fatty acid caprylic acid produced variable efficacy against enteric Campylobacter colonization in broilers.
Campylobacter is one of the most common causes of foodborne illness, and poultry are considered a primary source of Campylobacter infections. Caprylic acid, an 8-carbon fatty acid, has been shown in previous studies to reduce enteric cecal Campylobacter concentrations in poultry when administered in the feed. For greater ease of application for producers, a water-soluble form of caprylic acid, sodium octanoate, was evaluated for efficacy against enteric Campylobacter. The first trial consisted of 70 birds in 7 groups (n = 10 chicks/group): an untreated control and 6 other groups that were challenged with Campylobacter at d 3 and that received 0, 0.175, 0.35, 0.7, 1.4, or 2.8% water-soluble caprylic acid in water 3 d before necropsy at d 14. The second trial consisted of 80 birds in 8 groups (n = 10 chicks/group): an untreated negative control and 7 other groups, all of which were challenged with Campylobacter at d 3 and received 0, 0.044, 0.088, 0.175, 0.35, 0.7, or 1.4% water-soluble caprylic acid for 3 d before necropsy at d 14. In trial 1, only the 0.175% dose caused a reduction in cecal Campylobacter counts in comparison with the positive control (approximately a 3-log reduction). In trial 2, no treatment reduced Campylobacter counts compared with the positive control. Unlike the efficacy of caprylic acid in feed, treatment with caprylic acid in water had an inconsistent effect on intestinal Campylobacter counts.
Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.
J H
JH
Metcalf
A M
AM
Donoghue
K
K
Venkitanarayanan
I
I
Reyes-Herrera
V F
VF
Aguiar
P J
PJ
Blore
D J
DJ
Donoghue
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D002169:Campylobacter Infections / Q000517:prevention & control / Q000662:veterinary*; D016123:Campylobacter jejuni / Q000187:drug effects / Q000254:growth & development; D002210:Caprylates / Q000008:administration & dosage* / Q000494:pharmacology*; D002353:Carrier State; D002432:Cecum / Q000382:microbiology*; D002645:Chickens; D011201:Poultry Diseases / Q000382:microbiology / Q000517:prevention & control*; D014867:Water
D000900:Anti-Bacterial Agents; D002210:Caprylates; D014867:Water; C031492:octanoic acid