Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.
The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation). Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine.
Center of Regenerative Medicine in Barcelona, Dr. Aiguader, 88, 08003 Barcelona, Spain.
Chris
C
Jopling
Stephanie
S
Boue
Juan Carlos
JC
Izpisua Belmonte
D000818:Animals; D002453:Cell Cycle; D054337:Cell Dedifferentiation; D054338:Cell Transdifferentiation; D065150:Cellular Reprogramming; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D044968:Regenerative Medicine
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