The electrophysiology of the cardiac sodium channel.
Conduction in most regions of the heart is sustained by transient increases in membrane permeability to Na(+). The application of contemporary biophysical and molecular biologic techniques demonstrates that permeability to Na(+) depends on a distinct protein that forms ion-selective channels in the membrane. These channels are believed to be the site of action of the local anesthetic class of antiarrhythmic drugs. More detailed studies of the structure and function of the Na channel hold the prospect for a clearer understanding of the mechanisms and treatment of some arrhythmias.
Cardiovascular Division, Duke University School of Medicine, Durham, NC 27710, USA.
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