A new hepoprotective saponin from Semen Celosia cristatae.
A new triterpenoid saponin, named semenoside A (1), was isolated from Semen Celosia cristatae. Its structure was elucidated on the basis of 1D, 2D NMR, HR-FAB-MS and ESI-MS techniques, and physicochemical properties. The hepatoprotective activity of semenoside A with an oral dose of 1.0, 2.0 and 4.0mg/kg, respectively, were investigated by carbon tetrachloride (CCl(4))-induced hepatotoxicity in mice. The results indicated that it had significant hepatoprotective effects (p < 0.01).
Branch Hospital in Fengxian of Shanghai No 6 People's Hospital, 9588 NanFeng Road, Shanghai 201400, PR China.
Zhen-Liang
ZL
Sun
Gang-Long
GL
Gao
Yin-Fang
YF
Xia
Jing
J
Feng
Zeng-Yong
ZY
Qiao
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D034762:Celosia / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D051379:Mice; D015394:Molecular Structure; D008517:Phytotherapy; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D012639:Seeds / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D012503:Saponins; C560386:semenoside A