New genetic models for hypertension research.
Recent linkage studies in segregating populations derived from crosses of genetically hypertensive rats and normotensive rats have identified several chromosome regions that may contain genes involved in the pathogenesis of spontaneous hypertension. New genetic models for hypertension research, including recombinant inbred strains, congenic strains, and transgenic strains, are beginning to provide important opportunities for investigating whether certain candidate genes contribute to inherited variations in blood pressure. However, gene-targeting techniques that will enable the creation of new animal models with selective nucleotide substitutions will ultimately be required to determine the role of specific DNA variants in the pathogenesis of hypertension.
Department of Laboratory Medicine, University of California, San Francisco, CA 94143-0134, USA.
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Lezin
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Pravenec
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Kurtz