A simple and sensitive method for visual detection of heparin using positively-charged gold nanoparticles as colorimetric probes.
The electrostatic interaction between the negatively-charged heparin and the positively-charged gold nanoparticles leads to aggregation of gold nanoparticles and a color change from red to blue in solution, thus providing a simple and visual approach to colorimetric detection of heparin.
Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, PR China.
Rui
R
Cao
Baoxin
B
Li
D000042:Absorption; D003116:Color; D003124:Colorimetry / Q000379:methods*; D003543:Cysteamine / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006493:Heparin / Q000032:analysis*; D053768:Metal Nanoparticles / Q000737:chemistry*; D012996:Solutions; D055672:Static Electricity
D012996:Solutions; D003543:Cysteamine; D006046:Gold; D006493:Heparin