Japanese encephalitis virus: from genome to infectome.
Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical manifestations and pathogenesis of JEV infection are not well understood. Though, vaccines are currently available against JEV, it has to be further improved. Here we review the literature on the JEV life cycle, pathogenesis and host immune responses to JEV infection.
Laboratory of Neurovirology & Inflammation Biology, Section of Infectious Diseases, Centre for Cellular and Molecular Biology (CCMB), Council of Scientific and Industrial Research (CSIR), Uppal Road, Hyderabad, 500007 A.P., India.
Salini Krishnan
SK
Unni
Daniel
D
Růžek
Chintan
C
Chhatbar
Ritu
R
Mishra
Manish K
MK
Johri
Sunit K
SK
Singh
D000818:Animals; D004664:Encephalitis Virus, Japanese / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D004672:Encephalitis, Japanese / Q000473:pathology* / Q000517:prevention & control / Q000628:therapy; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D007109:Immunity; D014779:Virus Replication / Q000502:physiology