[Role of physiological factors in prognosis of the risk of oncological diseases development on the basis of xenobiotic metabolism enzyme system polymorphism].
Summarised data about polymorphism of xenobiotic metabolism enzyme system (XMES) have been presented. Metabolic molecular mechanisms and the role of genetic polymorphism in metabolic transformation of different xenobiotics are reviewed. Significance of X-transport proteins and nuclear receptors in regulation of XMES-activity are discussed. Possible connection of XMES polymorphism with the development of cancer was examined. Experimental modeling of different levels of epoxide syntase and epoxide hydratase activites has revealed their connection with cancer development. Physiological factors should be considered when evaluation of risk extent for cancer development is carried out.
V A
VA
Sukhanov
L A
LA
Piruzian
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics; D011110:Polymorphism, Genetic; D011379:Prognosis; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D015262:Xenobiotics / Q000378:metabolism*
D002352:Carrier Proteins; D009363:Neoplasm Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D015262:Xenobiotics