Role of glycogen in processes of cerebellar glial cells under conditions of its damage with sodium nitrite.
Ultrastructure of processes of glial cell, astrocytes of the molecular layer of cerebellar cortex in Rana temporaria frog, under conditions of damage to the cerebellum caused by NO-generating compound sodium nitrite was studied under an electron microscope. It was found that astrocytes have at least two types of processes: the first (fibrillar) primarily contained numerous fibrils and few glycogen granules and the second (granular) primarily containing glycogen granules. In the presence of NO-generating compound in toxic doses, fibrillar processes are damaged or completely degrade more rapidly than granular ones. The processes containing glycogen can protect both damaged synapses and individual synaptic buttons by forming a compact structure, wrapping, around them. We analyzed the possible role of glycogen of cerebellar glial cell processes in neuroglial interactions in the presence of sodium nitrite.
Laboratory No. 12,A. A. Kharkevich Institute of Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia.
N V
NV
Samosudova
V P
VP
Reutov
N P
NP
Larionova
D000818:Animals; D022081:Cell Surface Extensions / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure*; D002531:Cerebellum / Q000166:cytology* / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D009569:Nitric Oxide / Q000633:toxicity; D011896:Rana temporaria / Q000378:metabolism*; D012977:Sodium Nitrite / Q000633:toxicity*
D009569:Nitric Oxide; D006003:Glycogen; D012977:Sodium Nitrite