Improvement of cardiac function by intracoronary freshly isolated bone marrow cells transplantation in patients with acute myocardial infarction.
BACKGROUND
We analyzed in the present study the influence of intracoronary autologous freshly isolated bone marrow cells transplantation (BMCs-Tx) on cardiac function in patients with acute myocardial infarction (AMI).


RESULTS
The 32 patients with AMI were enrolled in this prospective nonrandomized study to either freshly isolated BMC-Tx or to a control group without cell therapy. Global left ventricular ejection fraction (LVEF) and the size of infarct area were determined by left ventriculography. We observed in patients with autologous freshly isolated BMCs-Tx at 6 months follow up a significant reduction of infarct size as compared to control group. Moreover, we found a significant increase of LVEF as well as infarct wall movement velocity at 6 months follow up in cell therapy group as compared to control group. In the control group there was no significant difference of LVEF, infarct size and infarct wall movement velocity between baseline and 6 months after AMI.


CONCLUSIONS
These results demonstrate for the first time that intracoronary transplantation of autologous freshly isolated BMCs by use of a point of care system is safe, and may lead to improvement of cardiac function in patients with AMI.
Department of Internal Medicine, Division of Cardiology, Rostock-University, Ernst Hydemann Str 6, 18055 Rostock, Germany. dr_g_turan@hotmail.com
Ramazan Gökmen
RG
Turan
Ilkay
I
Bozdag-Turan
Jasmin
J
Ortak
Ibrahim
I
Akin
Stephan
S
Kische
Henrik
H
Schneider
Tim Christopher
TC
Rehders
Cem Hakan
CH
Turan
Mathias
M
Rauchhaus
Tilo
T
Kleinfeldt
Tuschar
T
Chatterjee
Kurtulus
K
Sahin
Christoph A
CA
Nienaber
Hüseyin
H
Ince
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods*; D064987:Cell- and Tissue-Based Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D019095:Point-of-Care Systems; D011446:Prospective Studies; D013318:Stroke Volume / Q000502:physiology; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D055815:Young Adult