An emerging recombinant cluster of nephropathogenic strains of avian infectious bronchitis virus in Korea.
The infectious bronchitis virus (IBV) is continuously evolving through point mutation and recombination of their genome, subsequently the emergence of IBV variants complicates disease control. The objective of this study was to investigate genetic characterization of new IBV variants isolated from commercial chicken flocks in Korea collected between 2005 and 2010. Phylogenetic analysis revealed that all new IBV isolates belonged to Korean group II (K-II), which included the nephropathogenic IBV strains. However, the isolates formed a new gene cluster that was distinguished from the two distinct K-II subgroups (KM91-like and QX-like). Recombination events were identified in the S1 gene, with their putative parental strains being the KM91-like or QX-like subgroup. In addition, two crossover sites were observed in the S1 gene of IBV isolates. These results suggest that natural genetic recombination between heterologous strains classified into different genetic groups has occurred and may have caused the emergence of new IBV strains. This finding provides important information on IBV evolution and is essential for the effective control of IB in Korea.
Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul, Republic of Korea.
Tae-Hyun
TH
Lim
Hyun-Jeong
HJ
Lee
Dong-Hun
DH
Lee
Yu-Na
YN
Lee
Jae-Keun
JK
Park
Ha-Na
HN
Youn
Myung-Seob
MS
Kim
Joong-Bok
JB
Lee
Seung-Yong
SY
Park
In-Soo
IS
Choi
Chang-Seon
CS
Song
D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens; D018352:Coronavirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D001351:Infectious bronchitis virus / Q000145:classification / Q000235:genetics*; D016013:Likelihood Functions; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010802:Phylogeny; D011201:Poultry Diseases / Q000453:epidemiology / Q000821:virology*; D011995:Recombination, Genetic; D056910:Republic of Korea / Q000453:epidemiology; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014760:Viral Fusion Proteins / Q000235:genetics
D014760:Viral Fusion Proteins
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