Identification and characterization of the first ovothiol biosynthetic enzyme.
Ovothiols are histidine-derived thiols that were first isolated from marine invertebrates. We have identified a 5-histidylcysteine sulfoxide synthase (OvoA) as the first ovothiol biosynthetic enzyme and characterized OvoAs from  Erwinia tasmaniensis  and  Trypanosoma cruzi . Homologous enzymes are encoded in more than 80 genomes ranging from proteobacteria to animalia.
Abteilung Physikalische Biochemie, Max Planck Institut für Molekulare Physiologie, Otto-Hahn Strasse 11, 44227 Dortmund, Germany.
Andrea
A
Braunshausen
Florian P
FP
Seebeck
D000818:Animals; D019730:Carbon-Sulfur Ligases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004885:Erwinia / Q000201:enzymology*; D016678:Genome / Q000235:genetics; D008762:Methylhistidines / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D014349:Trypanosoma cruzi / Q000201:enzymology*
D008762:Methylhistidines; C050085:ovothiol C; D019730:Carbon-Sulfur Ligases