Functional motor-cortex mapping using corticokinematic coherence.
We present a novel method, corticokinematic coherence (CKC), for functional mapping of the motor cortex by computing coherence between cortical magnetoencephalographic (MEG) signals and the kinematics of voluntary movements. Ten subjects performed self-paced flexion-extensions of the right-hand fingers at about 3 Hz, with a three-axis accelerometer attached to the index finger. Cross-correlogram and coherence spectra were computed between 306 MEG channels and the accelerometer signals. In all subjects, accelerometer and coherence spectra showed peaks around 3-5 Hz and 6-10 Hz, corresponding to the movement frequencies. The coherence was statistically significant (P<0.05) in all subjects, with sources at the hand area of the primary motor cortex contralateral to the movement. CKC appears to be a promising and robust method for reliable and convenient functional mapping of the human motor cortex.
Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Bruxelles, Belgium. mabourgu@ulb.ac.be
Mathieu
M
Bourguignon
Xavier
X
De Tiège
Marc
M
Op de Beeck
Benoît
B
Pirotte
Patrick
P
Van Bogaert
Serge
S
Goldman
Riitta
R
Hari
Veikko
V
Jousmäki
D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D003627:Data Interpretation, Statistical; D019054:Evoked Potentials, Motor / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014836:Volition / Q000502:physiology*