Preparation and Evaluation of Nano-vesicles of Brimonidine Tartrate as an Ocular Drug Delivery System.
The objective of the present investigation was to design a vesicular formulation of brimonidine tartrate and evaluate its ability to reduce the dosing frequency and improve the therapeutic efficacy of the drug. Nano-vesicles of brimonidine tartrate were prepared by film hydration method. The prepared vesicles were evaluated for photomicroscopic characteristics, entrapment efficiency, in vitro, and ex-in vitro drug release and in vivo intraocular pressure (IOP) lowering activity. The methods employed for preparation of vesicles produced nano vesicles of acceptable shape and size. The in vitro, and ex-in vitro drug release studies showed that there was slow and prolonged release of the drug, which followed zero-order kinetics. The IOP-lowering activity of nano vesicles was determined and compared with that of pure drug solution and showed that the IOP-lowering action of nano-vesicles sustained for a longer period of time. Stability studies revealed that the vesicle formulations were stable at the temperature range of 2-8°C, with no change in shape and drug content. The results of the study indicate that it is possible to develop a safe and physiologically effective topical formulation that is also convenient for patients.
Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore-575 018, India.
P
P
Prabhu
Kumar R
KR
Nitish
M
M
Koland
Nm
N
Harish
K
K
Vijayanarayan
G
G
Dhondge
Rn
R
Charyulu
J Mol Biol. 1965 Aug;13(1):238-52
5859039
J Pharm Pharmacol. 2004 Dec;56(12):1509-17
15563757
J Microencapsul. 1998 Jul-Aug;15(4):485-94
9651870
Int J Pharm. 2000 Apr 20;199(2):119-27
10802405
Am J Ophthalmol. 1999 Nov;128(5):601-5
10577528
Int J Pharm. 2004 Jan 9;269(1):1-14
14698571
Am J Ophthalmol. 1999 May;127(5):511-5
10334342
J Pharm Sci. 1963 Dec;52:1145-9
14088963