Spray desorption collection: an alternative to swabbing for pharmaceutical cleaning validation.
Spray Desorption Collection (SDC) allows for much larger areas of surfaces to be sampled compared to traditional swabbing techniques, providing a valuable pre-concentration advantage. Closely related to desorption electrospray ionization (DESI), analytes from the sample surface are collected onto a selected collection surface, which in a second step can be analyzed directly. Here we demonstrate the application of SDC as a large surface area sampling tool coupled with paper spray MS (PS-MS) and demonstrate its capabilities for cleaning validation of pharmaceutical equipment for both acidic and basic active ingredients from an aluminium surface.
Department of Chemistry, Western Michigan University, Kalamazoo, Michigan, USA.
Shashank
S
Jain
Amy
A
Heiser
Andre R
AR
Venter
D000535:Aluminum / Q000737:chemistry; D001241:Aspirin / Q000032:analysis; D017336:Loratadine / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*
D004364:Pharmaceutical Preparations; D017336:Loratadine; D000535:Aluminum; D001241:Aspirin