[Relationship between coronary and abdominal calcification score, serum osteoprotegerin (OPG), and serum tartrate-resistant acid phosphatase (TRACP) -5b in pre-dialysis CKD patients].
Osteoprotegerin (OPG) inhibits interaction of the receptor-activator of nuclear factor-kappaB (RANK) ligand (RANKL) with its receptor RANK, which is expressed on osteoclasts. OPG appeared to accelerate vascular calcification in vitro by the inhibition of vascular osteoclast-like cells. On the contrary, early-onset arterial calcification was observed in OPG-deficient mice. We measured the coronary artery calcification score (CACS) and abdominal aortic calcification score (AAoCS) by multi-detector computed tomography in 30 pre-dialysis CKD patients (eGFR 20 mL/min on average). Biomarkers were measured, including serum OPG, soluble RANKL (sRANKL) and tartrate-resistant acid phosphatase (TRACP) -5b (the biomarker of osteoclasts independent of renal function). The median values of CACS and AAoCS were 54.4 and 1,088 Agatston units (AU), respectively. Serum OPG was increased and serum sRANKL was decreased. In a multivariate logistic regression analysis using CACS > or = 100 AU as the outcome variable, CACS was found to be positively correlated with serum corrected Ca x iP product and serum OPG, though it was not correlated with serum TRACP-5b. ROC curve analysis showed that the serum OPG cutoff value predicting CACS > or = 100 AU was 5.2 pmol/L (624 pg/mL). In a stepwise regression analysis, log (AAoCS + 1) was positively correlated with serum OPG alone, but it was not correlated with age, eGFR, serum albumin and bone alkaline phosphatase (BAP). No correlation was found between serum OPG and serum TRACP-5b. In conclusion, vascular calcification in pre-dialysis CKD patients was correlated with an increase in OPG, but was independent of serum TRACP-5b. The decrease in serum sRANKL may have been caused by the increase in OPG production.
Department of Internal Medicine, Kichijoji Asahi Hospital, Tokyo, Japan.
Jun
J
Shiota
Naoki
N
Izumi
Hitoshi
H
Kasahara
Hitoshi
H
Tagawa
Tetsuo
T
Chiba
Hiroshi
H
Nihei
D000135:Acid Phosphatase / Q000097:blood*; D001012:Aorta, Abdominal; D001018:Aortic Diseases / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002114:Calcinosis / Q000175:diagnosis*; D003327:Coronary Disease / Q000175:diagnosis*; D003331:Coronary Vessels; D003956:Dialysis; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D016015:Logistic Models; D008297:Male; D010010:Osteoclasts / Q000502:physiology; D053244:Osteoprotegerin / Q000097:blood*; D053245:RANK Ligand / Q000097:blood; D000071681:Tartrate-Resistant Acid Phosphatase
D015415:Biomarkers; D007527:Isoenzymes; D053244:Osteoprotegerin; D053245:RANK Ligand; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase