[GABAergic mechanism of cerebrovasculareffect of mexidol].
Experiments on rats showed that mexidol significantly increases local cerebral blood flow in animals under conditions of global transient brain ischemia, whereas in intact rats this drug initially causes a decrease in the blood flow, followed by its recovery. Mechanism of the cerebrovascular effect of mexidol is determined by its action on GABA receptors of cerebral vessels, which confirmed the fact that the cerebrovascular effect of mexidol is absent in the presence of bicuculline.
A V
AV
gnezdilova
T S
TS
Gan'shina
R S
RS
Mirzoian
D000818:Animals; D001640:Bicuculline / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004336:Drug Antagonism; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D008297:Male; D010847:Picolines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D018079:Receptors, GABA / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D058787:GABA-A Receptor Antagonists; D010847:Picolines; D011619:Psychotropic Drugs; D018079:Receptors, GABA; C070020:emoxypine succinate; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline