The genomic landscapes of inflammation.
Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.
Department of Experimental Oncology, European Institute of Oncology (IEO), I-20139 Milan, Italy. gioacchino.natoli@ifom-ieo-campus.it
Gioacchino
G
Natoli
Serena
S
Ghisletti
Iros
I
Barozzi
D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D008264:Macrophages / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors
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