Vascular calcification in chronic renal failure: what have we learned from animal studies?
Accelerated atherosclerotic plaque calcification and extensive medial calcifications are common and highly detrimental complications of chronic kidney disease. Valid murine models have been developed to investigate both pathologically distinguishable complications, which allow for better insight into the cellular mechanisms underlying these vascular pathologies and evaluation of compounds that might prevent or retard the onset or progression of vascular calcification. This review describes various experimental models that have been used for the study of arterial intimal and/or medial calcification and discusses the extent to which this experimental research has contributed to our current understanding of vascular calcification, particularly in the setting of chronic renal failure.
University of Antwerp, Department of Pathophysiology, Universiteitsplein 1, Wilrijk, Belgium.
Ellen
E
Neven
Patrick C
PC
D'Haese
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000502:physiology; D002114:Calcinosis / Q000503:physiopathology*; D002319:Cardiovascular System / Q000503:physiopathology*; D004195:Disease Models, Animal; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D011973:Receptors, LDL / Q000235:genetics / Q000502:physiology; D017539:Tunica Intima / Q000503:physiopathology; D017540:Tunica Media / Q000503:physiopathology
D001057:Apolipoproteins E; D011973:Receptors, LDL