Chelation of cadmium by combining deferasirox and deferiprone in rats.
The present research aimed to characterize the potential efficiency of two chelators after cadmium administration for 60 days following two dose levels of 20 and 40 mg/kg body weight daily to male rats. However, the hypothesis that the two chelators might be more efficient as combined therapy than as single therapy in removing cadmium from the body was considered. In this way, two known chelators deferasirox and deferiprone (L(1)) were chosen and tested in the acute rat model. Two chelators were given orally as a single or combined therapy for the period of a week. Cadmium and iron concentrations in various tissues were determined by graphite furnace and flame atomic absorption spectrometry methods, respectively. The combined chelation therapy results show that Deferasirox and L(1) are able to remove cadmium ions from the body while iron concentration returned to the normal level and symptoms are also decreased.
Chemistry Department, Shahid Bahonar University of Kerman, Kerman, Iran. fatemijam@yahoo.com
S
S
Jamilaldin Fatemi
Amir Shokooh
AS
Saljooghi
Faezeh Dahooee
FD
Balooch
Marzieh
M
Iranmanesh
Mohammad Reza
MR
Golbafan
D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D019187:Cadmium Compounds / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000188:drug therapy* / Q000378:metabolism; D015913:Chelation Therapy / Q000379:methods*; D000077588:Deferasirox; D000077543:Deferiprone; D004338:Drug Combinations; D007502:Iron Chelating Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D058085:Iron Compounds / Q000032:analysis / Q000378:metabolism; D008297:Male; D011728:Pyridones / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D014230:Triazoles / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*
D001565:Benzoates; D019187:Cadmium Compounds; D004338:Drug Combinations; D007502:Iron Chelating Agents; D058085:Iron Compounds; D011728:Pyridones; D014230:Triazoles; D000077543:Deferiprone; D000077588:Deferasirox