[New treatment options for primary immune thrombocytopenia].
Primary immune thrombocytopenia (ITP)--formerly known as idiopathic thrombocytopenic purpura--is an autoimmune disorder characterized by immune mediated thrombocytopenia. The aetiology of ITP remains unknown, but studies have shown that multiple immunological mechanisms are involved in the pathogenesis of ITP. This article aims to provide an overview of current treatment options, with particular emphasis on new biological therapies: rituximab, a monoclonal anti-CD20 antibody, and the thrombopoietin receptor agonists romiplostim and eltrombopag.
Afsnit 7521, Institut for Inflammationsforskning, Finsenscenter, Rigshospitalet, 2200 København N, Denmark. sif.gudbrandsdottir@gmail.com
Sif
S
Gudbrandsdottir
Henrik
H
Frederiksen
Henrik Sverre
HS
Birgens
Claus Henrik
CH
Nielsen
Ove Juul
OJ
Nielsen
Jesper
J
Stentoft
Hans Carl
HC
Hasselbalch
D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001565:Benzoates / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006834:Hydrazines / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D011720:Pyrazoles / Q000627:therapeutic use; D011961:Receptors, Fc / Q000627:therapeutic use; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D000069283:Rituximab; D013156:Splenectomy; D013926:Thrombopoietin / Q000627:therapeutic use
D058846:Antibodies, Monoclonal, Murine-Derived; D001565:Benzoates; D005938:Glucocorticoids; D006834:Hydrazines; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D011720:Pyrazoles; D011961:Receptors, Fc; D011993:Recombinant Fusion Proteins; D000069283:Rituximab; D003907:Dexamethasone; D013926:Thrombopoietin; D011239:Prednisolone; C488777:romiplostim; C520809:eltrombopag