Inverse vaccination to silence immunity to myelin in multiple sclerosis.
The adaptive immune response in multiple sclerosis is complex. We have devised large scale arrays to measure the antibody response to myelin proteins and lipids. Despite the widespread immune responses to myelin, we have devised an inverse vaccine aimed at turning off key drivers of this diverse response. Clinical trials in patients with multiple sclerosis show that it is possible to constrain antibody responses to myelin on a large scale with this approach.
Department of Neurological Sciences and Interdepartmental Program in Immunology, Stanford University, Stanford, California, 94305, USA.
Lawrence
L
Steinman
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D002986:Clinical Trials as Topic; D006801:Humans; D008055:Lipids / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy*; D009186:Myelin Sheath / Q000276:immunology* / Q000378:metabolism; D010446:Peptide Fragments / Q000276:immunology / Q000627:therapeutic use; D040081:Protein Array Analysis / Q000379:methods; D014611:Vaccination / Q000295:instrumentation / Q000379:methods*
D008055:Lipids; D010446:Peptide Fragments