Ligand-free copper-catalyzed arylation of amidines.
Copper-catalyzed cross-coupling reactions of amidine salts were utilized to synthesize monoarylated amidines in moderate to high yields with ligand-free conditions. DMF was the superior solvent for the N-arylation of benzamidines, while MeCN was used in the formation of N-aryl amidines in moderate to high yield.
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE 205A, Tampa, Florida 33620, USA.
Michelle
M
Cortes-Salva
Corey
C
Garvin
Jon C
JC
Antilla
D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000578:Amidines; D003300:Copper