[Cytochrome P4501A1, glutathione S-transferase M1 and T1 gene polymorphisms in chronic myeloid leukemia].
Polymorphic variants of cytochrome P4501A1 (CYP1A1), glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) distribution was studied in patients with chronic myeloid leukemia (CML) and healthy individuals. It was shown that homozygotes for the GSTT1 gene deletion occur significantly more frequently in the CML patient group compared to the control group (13.17% versus 24.10% in CML patients, Chi2 = 4.40, p < 0.05; OR = 2.09; 95% CI = 1.10-3.99). In contrast, no significant difference was observed between the healthy individuals and CML patients in the frequency of polymorphic variants of GSTM1 and CYP1A1 genes (p > 0.05).
V A
VA
Ovsepian
E Iu
EIu
Vinogradova
E S
ES
Sherstneva
D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D017353:Gene Deletion; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D009363:Neoplasm Proteins; C413545:glutathione S-transferase T1