Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor.
Novel p-iodobenzoate-based labelling reagents are shown to be effective photocaged precursors for synthesizing biomolecular radicals site-selectively in the gaseous and condensed phases. In vacuo, a single pulse of UV photons (266 nm) is sufficient to quantitatively photolyse the C-I bond. In aqueous solutions, the photolysis half-life is estimated to be 2.5 minutes when irradiating with a 15 W compact fluorescent lamp (254 nm).
Department of Chemistry, University of California, Riverside, Riverside, CA, USA. tly@dundee.ac.uk
Tony
T
Ly
Xing
X
Zhang
Qingyu
Q
Sun
Benjamin
B
Moore
Yuanqi
Y
Tao
Ryan R
RR
Julian
D000595:Amino Acid Sequence; D001665:Binding Sites; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D007462:Iodobenzenes / Q000737:chemistry; D007700:Kinetics; D009842:Oligopeptides / Q000737:chemistry*; D010782:Photolysis; D013379:Substrate Specificity; D014466:Ultraviolet Rays
D005609:Free Radicals; D007462:Iodobenzenes; D009842:Oligopeptides; C031905:iodobenzene