Immunomodulatory drugs and their application to the management of canine immune-mediated disease.
This review summarises the current understanding of immune response and T cell subsets in the context of development of autoimmunity in the dog. Mode of action and rational usage in immune-mediated disease in the dog are discussed for the following drugs: glucocorticoids, azathioprine, cyclophosphamide, ciclosporin, tacrolimus, human intravenous immunoglobulin, vincristine, danazol, leflunomide, mycophenolate mofetil and liposome-encapsulated clodronate. Disease mechanisms are discussed and published evidence for drug efficacy is scrutinised for five important immune-mediated diseases: immune-mediated haemolytic anaemia, immune-mediated thrombocytopenia, myasthenia gravis, glomerulonephritis and inflammatory bowel disease. Future strategies for more refined manipulation of adverse immune responses are presented.
Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hertfordshire.
N T
NT
Whitley
M J
MJ
Day
D000818:Animals; D015551:Autoimmunity; D004283:Dog Diseases / Q000188:drug therapy* / Q000276:immunology*; D004285:Dogs; D007154:Immune System Diseases / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D056747:Immunomodulation; D007166:Immunosuppressive Agents / Q000627:therapeutic use*
D007166:Immunosuppressive Agents