Transient haemodynamic events in neurologically compromised infants: a simultaneous EEG and diffuse optical imaging study.
We describe a series of novel simultaneous EEG and diffuse optical imaging studies of newborn infants. These experiments provide evidence of large, transient haemodynamic events which occur repeatedly and consistently within and across several infants with neurological damage, all of whom were diagnosed with seizures. A simple but independent process of rejecting artifacts and identifying events within diffuse optical imaging data is described, and this process is applied to data from 4 neurologically damaged neonates and from 19 healthy, age-matched controls. This method results in the consistent identification of events in three out of four of the neurologically damaged infant group which are dominated by a slow (>30s) and significant increase in oxyhaemoglobin concentration, followed by a rapid and significant decrease before a slow return to baseline. No comparable events are found in any of our control data sets. The importance and physiological implications of our findings are discussed, as is the suitability of a combined EEG and diffuse optical imaging approach to the study and monitoring of neonatal brain injury.
Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, London, UK. rcooper@medphys.ucl.ac.uk
R J
RJ
Cooper
Jeremy C
JC
Hebden
H
H
O'Reilly
S
S
Mitra
A W
AW
Michell
N L
NL
Everdell
A P
AP
Gibson
T
T
Austin
D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D010100:Oxygen / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D010100:Oxygen