Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women.
Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P < .05), HSP70, IGF-I, and insulin (P < .01). The training-induced reductions in CRP and TNF-α were significantly (P < .01, P < .05) associated with increased muscle thickness (r = -0.61, r = -0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.
Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo 173-0015, Japan. kishiko@tmig.or.jp
Kishiko
K
Ogawa
Kiyoshi
K
Sanada
Shuichi
S
Machida
Mitsuharu
M
Okutsu
Katsuhiko
K
Suzuki
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002097:C-Reactive Protein / Q000096:biosynthesis; D018932:Chemokine CCL2 / Q000096:biosynthesis; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis; D006801:Humans; D006984:Hypertrophy / Q000473:pathology*; D007249:Inflammation / Q000628:therapy*; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000097:blood; D009132:Muscles / Q000473:pathology*; D055070:Resistance Training; D000685:Serum Amyloid A Protein / Q000096:biosynthesis; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
D018932:Chemokine CCL2; D018840:HSP70 Heat-Shock Proteins; D007328:Insulin; D007375:Interleukin-1; D015850:Interleukin-6; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein
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