[In vivo studies on metabolic network compatibility of herba houttuyniae injection and sodium neohouttuynin injection in rats].
OBJECTIVE
To study metabolic rule in rats for heartleaf houttuynia herb injection and Sodium New Houttuyfonate injection.


METHODS
The GC-MS was used to determine metabolites in plasma and urine of rats after intravenous and oral administration of heartleaf houttuynia herb injection as multi-component and Sodium New Houttuyfonate injection as single component.


RESULTS
For rats 8 common metabolites were determined in plasma after intravenous administration of heartleaf houttuynia herb injection and Sodium New Houttuyfonate injection, meanwhile 39 in urine. The 16 common metabolites were determined in plasma after oral administration, and 12 in urine. The 9 and 11 of same metabolites were determined in plasma and urine respectively after intravenous and oral administration of heartleaf houttuynia herb injection, 8 and 17 common metabolites for Sodium New Houttuyfonate injection.


CONCLUSIONS
The metabolites of heartleaf houttuynia herb and Sodium New Houttuyfonate injection in rats are the same or similar after intravenous and oral administration, and there are the same structure types between metabolites and original constituents of preparations. The metabolic pathways of the two preparations in rats are the same. There is metabolic Network Compatibility in organism between multi-components, single components and different administration forms for traditional Chinese medicine.
Department of Pharmaceutics, Hunan University of Traditional Chinese Medicine, Changsha 410208, China. qiuyun1985@126.com
Yun
Y
Qiu
Fu-Yuan
FY
He
Li-Min
LM
Gong
Sheng
S
Huang
Huan
H
Zou
Feng
F
Chen
Jie-Ying
JY
Luo
D000284:Administration, Oral; D000447:Aldehydes / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D053858:Metabolic Networks and Pathways; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D032134:Saururaceae / Q000737:chemistry*
D000447:Aldehydes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C023969:decanoyl acetaldehyde