Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic autoimmune disease and can lead to deformities and severe disabilities, due to irreversible damage of tendons, joints, and bones. Previous study indicated that DNA repair system was involved in the pathology of RA. In this study, we investigated the association of two 8-oxoguanine glycosylase 1 (OGG1) gene polymorphisms (rs159153 and rs3219008) with the susceptibility to RA in 384 Taiwanese individuals (192 patients with RA and 192 controls). Our data showed that statistically significant difference in genotype frequency distributions was found at rs3219008 SNP between patients with RA and control groups (P = 5.6E-0.5). Our data also indicated that individuals with the AG genotype at rs3219008 SNP may have a higher risk of developing RA. We did not observe any statistically significant association of OGG1 haplotype frequencies (rs159153 and rs3219008) with RA progression. The study suggested that OGG1 polymorphisms (rs159153 and rs3219008) are associated with RA progression and that these may be used as molecular markers of RA.
Genetic Center, Department of Medical Research, China Medical University Hospital, Graduate Institute of Chinese Medical Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Shih-Yin
SY
Chen
Lei
L
Wan
Chung-Ming
CM
Huang
Yu-Chuen
YC
Huang
Jim Jinn-Chyuan
JJ
Sheu
Ying-Ju
YJ
Lin
Shih-Ping
SP
Liu
Yu-Ching
YC
Lan
Chih-Ho
CH
Lai
Cheng-Wen
CW
Lin
Chang-Hai
CH
Tsai
Fuu-Jen
FJ
Tsai
D001172:Arthritis, Rheumatoid / Q000201:enzymology / Q000235:genetics* / Q000401:mortality; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D045647:DNA Glycosylases / Q000235:genetics*; D004260:DNA Repair; D018450:Disease Progression; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D013624:Taiwan
D005819:Genetic Markers; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human
Hum Genet. 2007 Apr;121(2):233-42
17203305
Arthritis Rheum. 1997 Feb;40(2):341-51
9041946
Hum Genet. 2003 Jan;112(1):34-41
12483297
J Rheumatol. 1995 Aug;22(8):1450-4
7473464
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):811-5
16614128
Nat Genet. 2002 Dec;32(4):650-4
12426569
Trends Mol Med. 2003 Oct;9(10):405-7
14557050
Arthritis Rheum. 1988 Mar;31(3):315-24
3358796
J Rheumatol. 2008 Nov;35(11):2113-8
19004052
Bioinformatics. 2005 Jan 15;21(2):263-5
15297300
Am J Hum Genet. 1995 Jul;57(1):150-9
7611283
Clin Exp Rheumatol. 2008 Jul-Aug;26(4):632-7
18799095
Springer Semin Immunopathol. 1998;20(1-2):5-22
9836366
J Clin Invest. 2008 Jul;118(7):2516-25
18521188
FASEB J. 2003 Jul;17(10):1195-214
12832285
Nat Genet. 2003 Aug;34(4):395-402
12833157
J Rheumatol. 1990 Feb;17(2):127-33
2181124
FASEB J. 2005 Feb;19(2):290-2
15677345
Arthritis Rheum. 1991 Jul;34(7):822-30
2059230
Cell. 1996 May 3;85(3):307-10
8616886
J Exp Med. 2009 Jun 8;206(6):1435-49
19451263
Mutat Res. 2005 Jun 3;573(1-2):136-51
15829243
DNA Cell Biol. 2009 Nov;28(11):579-88
19630534
N Engl J Med. 1990 May 3;322(18):1277-89
2271017
J Hum Genet. 2001;46(8):471-7
11501945
Clin Exp Rheumatol. 2004 Mar-Apr;22(2):219-22
15083890