Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse.
Genetic variations in the gene encoding dysbindin has consistently been associated with schizophrenia and bipolar disorder, although little is known about the neural functions carried out by dysbindin. To gain some insight into this area, we took advantage of the readily available dysbindin-null mouse sandy (sdy-/-) and studied hippocampal neurogenesis using thymidine analogue bromodeoxuridine (BrdU). No significant differences were found in the proliferation (4 hours) or survival (1, 4 and 8 weeks after the last BrdU injection) of progenitors in the subgranular regions of the dentate gyrus between sdy-/- and sdy+/+ (control) mice. However, 4 weeks after the last BrdU injection, a significant reduction was observed in the ratio of neuronal differentiation in sdy-/- when compared to that of sdy+/+ (sdy+/+  = 87.0 ± 5.3% vs. sdy-/-  = 71.3 ± 8.3%, p = 0.01). These findings suggest that dysbindin plays a role during differentiation process in the adult hippocampal neurogenesis and that its deficit may negatively affect neurogenesis-related functions such as cognition and mood.
Mood Disorders Research Team, Tokyo Institute of Psychiatry, Tokyo, Japan.
Naomi
N
Nihonmatsu-Kikuchi
Ryota
R
Hashimoto
Satoko
S
Hattori
Shinsuke
S
Matsuzaki
Takiko
T
Shinozaki
Haruka
H
Miura
Shigeru
S
Ohota
Masaya
M
Tohyama
Masatoshi
M
Takeda
Yoshitaka
Y
Tatebayashi
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D018891:Dentate Gyrus / Q000166:cytology*; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D006624:Hippocampus / Q000166:cytology; D051379:Mice; D008817:Mice, Mutant Strains; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology*; D013997:Time Factors
D002352:Carrier Proteins; C498992:Dtnbp1 protein, mouse; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins
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