A novel small molecule fluorescent sensor for Zn2+ based on pyridine-pyridone scaffold.
The development of a water-soluble and small molecular weight fluorescent probe, 3-(4-methoxyphenyl)-4-(methylsulfanyl)-6-(pyridin-2-yl)pyridin-2(1H)-one (3), for detecting Zn(2+) based on pyridine-pyridone skeleton is reported. We observed a clear chelation enhanced fluorescence effect of 3 in the presence of Zn(2+). Other fluorescent properties of 3 are discussed.
Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Japan.
Masayori
M
Hagimori
Naoko
N
Mizuyama
Yasuchika
Y
Yamaguchi
Hideo
H
Saji
Yoshinori
Y
Tominaga
D002614:Chelating Agents / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D002614:Chelating Agents; D005456:Fluorescent Dyes; D011725:Pyridines; D011728:Pyridones; D014867:Water; D015032:Zinc