Peripartum anesthetic management of a patient with brittle cornea syndrome.
Brittle cornea syndrome (BCS) is a rare autosomal recessive disease that affects the connective tissue. The syndrome is caused by genetic changes in the 4.7-Mb interval between the D16S3423 and D16S3425 markers on the 16q24 chromosome and mutations in the Zinc-Finger 469 gene (ZNF469). BCS is characterized by thin and fragile cornea that tends to perforate spontaneously or as a result of minor trauma to the eye. In addition, the patient usually suffers from hearing loss, mental retardation, hyperextensibility of skin and joints, as well as varying degrees of scoliosis. This phenotypical expression presents an interesting challenge to anesthetic care. We briefly present the perioperative management of a patient with BCS who underwent three cesarean sections.
Department of Anesthesiology, Perioperative Medicine and Pain Treatment, Shaare Zedek Medical Centre, Hebrew University, POB 3235, 91031, Jerusalem, Israel. aioscovich@gmail.com
A
A
Ioscovich
S
S
Grisaru-Granovsky
S
S
Halpern
Y
Y
Shapiro
D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000732:Androstanols / Q000627:therapeutic use; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000627:therapeutic use; D002585:Cesarean Section; D004535:Ehlers-Danlos Syndrome / Q000150:complications; D005124:Eye Abnormalities; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000151:congenital; D008614:Meperidine / Q000627:therapeutic use; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use; D011247:Pregnancy; D015742:Propofol / Q000627:therapeutic use; D000077123:Rocuronium; D012868:Skin Abnormalities; D013390:Succinylcholine / Q000627:therapeutic use
D000701:Analgesics, Opioid; D000732:Androstanols; D018686:Anesthetics, Intravenous; D003473:Neuromuscular Nondepolarizing Agents; D008614:Meperidine; D013390:Succinylcholine; D000077123:Rocuronium; D015742:Propofol