Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound.
Protein-bound polysaccharide K (PSK) is extracted and purified from Coriolus versicolor (CM101), and is used as an anti-cancer agent. In this study, focusing on the direct actions of PSK, we investigated whether PSK reaches tumor and immune tissues with its active structure remaining intact, and the direct action of PSK was evaluated by its antitumor effects against MethA fibrosarcomas implanted in immunodeficient NOD/SCID mice. The results obtained suggest that PSK reaches the tumor tissue in its active form and exhibits antitumor effects against MethA cells.
Biomedical Research Laboratories, Kureha Corp, 3-26-2, Hyakunin-cho, Shinjuku-ku, Tokyo 169-8503, Japan. h-hoshi@kureha.co.jp
Hirotaka
H
Hoshi
Hikaru
H
Saito
Hiroko
H
Iijima
Motoyuki
M
Uchida
Tsutomu
T
Wada
Gentaro
G
Ito
Hiroaki
H
Tanaka
Tetsuji
T
Sawada
Kosei
K
Hirakawa
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D011509:Proteoglycans / Q000276:immunology / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D011509:Proteoglycans; C010770:polysaccharide-K