Semi-synthetic polysaccharide sulfates as anticoagulant coatings for PET, 1--cellulose sulfate.
In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material.
Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Centre of Excellence for Polysaccharide Research, Humboldtstraße 10, D-07743 Jena, Germany.
Martin
M
Gericke
Aleš
A
Doliška
Jan
J
Stana
Tim
T
Liebert
Thomas
T
Heinze
Karin
K
Stana-Kleinschek
D000328:Adult; D000925:Anticoagulants / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D006801:Humans; D008297:Male; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry*; D011093:Polyethylene Terephthalates
D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D011093:Polyethylene Terephthalates; D011092:Polyethylene Glycols; D002482:Cellulose; C020254:cellulose sulfate