Calamenenes--aromatic bicyclic sesquiterpenes--from the Indian gorgonian Subergorgia reticulata (Ellis and Solander, 1786).
Three aromatic sesquiterpene derivatives, (+)-(7R, 10S)-2-methoxy calamenene (1), (+)-(7R, 10S)-2,5-dimethoxy calamenene (2) and (+)-(7R, 10S)-2-methoxy-5-acetoxy calamenene (3) were isolated from the methanol extract of the Indian gorgonian Subergorgia reticulata. Compound 2 has not been previously described in the literature. Compound 3 has not been isolated previously from a natural source. Compounds 1, 2 and 3 showed settlement inhibition activity against cyprids of Balanus amphitrite with EC(50) values of 4.4, 7.8 and 0.03 µg mL(-1), respectively. These compounds also exhibited considerable activity against Artemia nauplii at 50 µg mL(-1), indicative of their potential use as cytotoxic agents.
National Institute of Oceanography, Regional Centre, Council of Scientific and Industrial Research, Kochi 682 018, India.
V P
VP
Limna Mol
T V
TV
Raveendran
B G
BG
Naik
R J
RJ
Kunnath
P S
PS
Parameswaran
D006801:Humans; D007194:India; D009682:Magnetic Resonance Spectroscopy; D000081223:Polycyclic Sesquiterpenes; D013729:Terpenes / Q000008:administration & dosage*
D000081223:Polycyclic Sesquiterpenes; D013729:Terpenes; C502644:calamenene