Image printing on the surface of anti-biofouling zwitterionic polymer brushes by ion beam irradiation.
A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furthermore, the PCMB brush was ablated and a hollow space with a designed shape could be made to which HEK293 cells (from human embryonic kidney) and Hep G2 (from human hepatoma) cells non-specifically adhered, while no adhesion of these cells to the non-treated area on the brush was observed. The present results clearly indicate the usefulness of ion beam-printed patterns of anti-biofouling zwitterionic polymer brushes in the biomedical field.
Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, Toyama 930-8555, Japan. kitano@eng.u-toyama.ac.jp
Hiromi
H
Kitano
Hisatomo
H
Suzuki
Takuya
T
Kondo
Kenta
K
Sasaki
Shintaroh
S
Iwanaga
Makoto
M
Nakamura
Kohji
K
Ohno
Yoshiyuki
Y
Saruwatari
D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007477:Ions; D011109:Polymethacrylic Acids / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D007477:Ions; D011109:Polymethacrylic Acids