Neonatal IVH--mechanisms and management.
Intra-ventricular hemorrhage (IVH) occurs predominantly in very low birth weight premature infants. Survivors of severe IVH frequently experience long-term consequences including major neurological deficits. Advances in neonatal and obstetric care in the last decades, have led to a steady decline in mortality and in the incidence of IVH. However, significant improvements in the survival rates small premature infants have led to an increase in the population of newborns prone to IVH. The pathogenesis of IVH is multifactorial. Prematurity of the germinal matrix, fluctuations in cerebral blood flow, hypoxic ischemic cerebral injury and developmental hemostatic abnormalities of newborns are important risk factors. The following manuscript will address the epidemiology and pathogenesis of IVH and review studies regarding potential pro-coagulant therapy.
Thrombosis Unit, National Hemophilia Center, Sheba Medical center, Tel Hashomer, Israel. Gili.kenet@sheba.health.gov.il
Gili
G
Kenet
Amir A
AA
Kuperman
Tzipora
T
Strauss
Benjamin
B
Brenner
D001779:Blood Coagulation Factors / Q000378:metabolism / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000453:epidemiology* / Q000473:pathology; D003029:Coagulants / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D019102:Infant, Very Low Birth Weight / Q000097:blood
D001779:Blood Coagulation Factors; D003029:Coagulants