Rh(I)-catalyzed formal [5 + 1]/[2 + 2 + 1] cycloaddition of 1-yne-vinylcyclopropanes and two CO units: one-step construction of multifunctional angular tricyclic 5/5/6 compounds.
A novel Rh(I)-catalyzed formal [5 + 1]/[2 + 2 + 1] cycloaddition of 1-yne-vinylcyclopropanes and two CO units for the construction of multifunctional angular tricyclic 5/5/6 skeletons with one or two adjacent bridgehead quaternary all-carbon stereocenters in one step has been developed. Preliminary density functional theory calculations have been carried out to investigate the reaction mechanism and the substituent effects.
Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry, Peking University, Beijing 100871, China.
Mu
M
Lin
Feng
F
Li
Lei
L
Jiao
Zhi-Xiang
ZX
Yu