Genotoxic effects of aluminum, iron and manganese in human cells and experimental systems: a review of the literature.
There is considerable evidence indicating an increase in neurodegenerative disorders in industrialized countries. The clinical symptoms and the possible mutagenic effects produced by acute poisoning and by chronic exposure to metals are of major interest. This study is a review of the data found concerning the genotoxic potential of three metals: aluminum (Al), iron (Fe) and manganese (Mn), with emphasis on their action on human cells.
Molecular Biology Laboratory, Center of Biological and Health Sciences, Estadual University of Pará, Belém/PA, Brazil.
P D L
PD
Lima
M C
MC
Vasconcellos
R C
RC
Montenegro
M O
MO
Bahia
E T
ET
Costa
L M G
LM
Antunes
R R
RR
Burbano
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000139:chemically induced; D006801:Humans; D007501:Iron / Q000633:toxicity*; D008345:Manganese / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation
D009153:Mutagens; D008345:Manganese; D000535:Aluminum; D007501:Iron