Diffusion-weighted magnetic resonance imaging for prediction of response of advanced cervical cancer to chemoradiation.
OBJECTIVE
The aim of the study was to investigate diffusion-weighted imaging as an early predictor in detection of response to chemoradiation in advanced cervical cancer.


METHODS
Fourteen advanced cervical cancer patients treated with chemoradiation were enrolled in this study. All patients underwent conventional magnetic resonance imaging and diffusion-weighted imaging before the start of therapy, after 2 weeks of therapy, and at the completion of therapy. The tumor volumes and apparent diffusion coefficient (ADC) values of cervical lesions were measured at each examination. The correlation of ADC values and tumor regression was investigated.


RESULTS
The mean ADC value of cervical lesion significantly increased as early as 2 weeks after chemoradiation. The ADC values before therapy did not significantly correlate with tumor response. The ADC values after 2 weeks of therapy did not show a significant correlation with tumor response. The change in ADC values after 2 weeks of therapy correlated with tumor response.


CONCLUSIONS
Diffusion-weighted imaging may provide an early surrogate biomarker for tumor response in advanced cervical cancers.
State Key Laboratory of Oncology in South, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Yun
Y
Zhang
Jian-Yu
JY
Chen
Chuan-Miao
CM
Xie
Yun-Xian
YX
Mo
Xue-Wen
XW
Liu
Yi
Y
Liu
Pei-Hong
PH
Wu
D000328:Adult; D000368:Aged; D015415:Biomarkers; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*
D015415:Biomarkers