Comparative analysis of tissue availability for afobazole and compound M-11.
Comparative analysis of pharmacokinetic parameters of afobazole and its main metabolite M-11 after single intraperitoneal injections of their solutions (25 mg/kg) to rats showed much more intense penetration of M-11 compared to afobazole into rat tissues and organs, judging from the area under the pharmacokinetic curve (AUC) and maximum concentrations (C(max)). The half-life periods (T(l/2e)l) of afobazole and M-11 were similar.
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. aviglinskaya@gmail.com
A O
AO
Viglinskaya
D V
DV
Bastrygin
G B
GB
Kolyvanov
A A
AA
Litvin
V P
VP
Zherdev
T Ya
TY
Mozhaeva
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001562:Benzimidazoles / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; C558388:2-(2-(3-hydroxymorpholin-4-yl)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines