Age and gender specific pediatric reference intervals for aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin, and uric acid.
BACKGROUND
Reference intervals can vary based on age and gender. Proper partitioning is necessary to classify health status in different age groups.


METHODS
Seven analytes; aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin and uric acid; were assayed on Roche Modular P analyzers using serum samples from 1765 children (867 females and 898 males; age range, 6 months to 17 y). Subjects 6 months up to 7 y were undergoing minor surgical procedures. Children 7 to 17 y were apparently healthy. Subjects with significant medical history or who were taking any medications were excluded.


RESULTS
Separate reference intervals for boys and girls were required for 33% of the groups. Aldolase showed gender variation in the 6-8, 12-14, and 15-17 y. Amylase was the only analyte that showed no significant gender differences within any age group. Both ceruloplasmin and uric acid had significant differences between the 12-14 and 15-17 y groups. Creatine kinase exhibited statistically significant gender differences in all age groups with the exception of 6-8 y.


CONCLUSIONS
We verified that when establishing pediatric reference intervals, partitioning by age and gender is frequently necessary.
Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Sarah M
SM
Clifford
Ashley M
AM
Bunker
Jeffrey R
JR
Jacobsen
William L
WL
Roberts
D000293:Adolescent; D000367:Age Factors; D000681:Amylases / Q000097:blood; D001774:Blood Chemical Analysis / Q000592:standards*; D002570:Ceruloplasmin / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D055292:Pancreatic alpha-Amylases / Q000032:analysis; D011228:Prealbumin / Q000032:analysis; D012016:Reference Values; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood
D011228:Prealbumin; D014527:Uric Acid; D002570:Ceruloplasmin; D003402:Creatine Kinase; D000681:Amylases; D055292:Pancreatic alpha-Amylases; D005634:Fructose-Bisphosphate Aldolase