A wireless multi-channel neural amplifier for freely moving animals.
Conventional neural recording systems restrict behavioral experiments to a flat indoor environment compatible with the cable that tethers the subject to recording instruments. To overcome these constraints, we developed a wireless multi-channel system for recording neural signals from rats. The device takes up to 64 voltage signals from implanted electrodes, samples each at 20 kHz, time-division multiplexes them into one signal and transmits that output by radio frequency to a receiver up to 60 m away. The system introduces <4 μV of electrode-referred noise, comparable to wired recording systems, and outperforms existing rodent telemetry systems in channel count, weight and transmission range. This allows effective recording of brain signals in freely behaving animals. We report measurements of neural population activity taken outdoors and in tunnels. Neural firing in the visual cortex was relatively sparse, correlated even across large distances and was strongly influenced by locomotor activity.
Program in Biophysics, Harvard University, Cambridge, Massachusetts, USA. szuts@fas.harvard.edu
Tobi A
TA
Szuts
Vitaliy
V
Fadeyev
Sergei
S
Kachiguine
Alexander
A
Sher
Matthew V
MV
Grivich
Margarida
M
Agrochão
Pawel
P
Hottowy
Wladyslaw
W
Dabrowski
Evgueniy V
EV
Lubenov
Athanassios G
AG
Siapas
Naoshige
N
Uchida
Alan M
AM
Litke
Markus
M
Meister
D000669:Amplifiers, Electronic; D000818:Animals; D004567:Electrodes, Implanted; D004867:Equipment Design; D008839:Microelectrodes; D051381:Rats; D013686:Telemetry / Q000295:instrumentation*
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