Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice.
Fibrocytes of the spiral limbus are thought to play a significant role in maintaining ion homeostasis in the cochlea. The present study measured physiological and morphological changes in spiral limbus of mice in response to noise exposure. 6-week-old male C3H/HeJJcl mice were exposed to octave-band noise (120 dB SPL) for 2 h and evaluated at a series of times thereafter, up to 8 weeks. Permanent hearing loss resulted in the mice, as assessed by auditory brainstem response (ABR) recordings. The fibrocytes loss was found in the spiral limbus of the apical turn, which has been proved to be induced by apoptosis. These results suggest that noise exposure might result in apoptosis of fibrocytes in spiral limbus, which suggest a mechanism for noise-induced hearing loss.
Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Yong
Y
Cui
Guang-Wei
GW
Sun
Daisuke
D
Yamashita
Sho
S
Kanzaki
Tatsuo
T
Matsunaga
Masato
M
Fujii
Kimitaka
K
Kaga
Kaoru
K
Ogawa
D000161:Acoustic Stimulation; D000818:Animals; D017209:Apoptosis; D003051:Cochlea / Q000473:pathology*; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem; D006317:Hearing Loss, Noise-Induced / Q000209:etiology* / Q000473:pathology*; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013997:Time Factors
Hear Res. 2000 Jan;139(1-2):13-30
10601709
J Comp Neurol. 2004 Nov 1;479(1):103-16
15389608
Hear Res. 2000 Apr;142(1-2):203-11
10748339
Hear Res. 1996 Jul;96(1-2):41-5
8817305
Brain Res. 2003 Mar 28;967(1-2):1-10
12650960
Hear Res. 2000 Jul;145(1-2):111-22
10867283
Noise Health. 2003 Jul-Sep;5(20):19-28
14558889
Hear Res. 2001 May;155(1-2):82-90
11335078
Brain Res. 2006 Jan 12;1068(1):237-47
16376312
J Comp Neurol. 2004 Feb 9;469(3):377-90
14730589
Am J Otolaryngol. 1990 Mar-Apr;11(2):99-111
2344002
Hear Res. 1999 May;131(1-2):1-10
10355599
J Assoc Res Otolaryngol. 2002 Sep;3(3):248-68
12382101
Acta Otolaryngol Suppl. 1978;358:1-63
281107
Hear Res. 1987;26(1):65-88
3558144
Otolaryngol Head Neck Surg. 1998 May;118(5):576-83
9591853
J Assoc Res Otolaryngol. 2003 Sep;4(3):339-52
14690052
Neuroreport. 1998 Jun 22;9(9):2109-14
9674603
Acta Otolaryngol. 2004 May;124(4):459-63
15224875
Hear Res. 2007 Feb;224(1-2):34-50
17175124
Scan Electron Microsc. 1982;(Pt 4):1753-62
7184149
Hear Res. 2002 Mar;165(1-2):1-9
12031509
Science. 1999 Aug 27;285(5432):1408-11
10464101
Acta Otolaryngol. 1999;119(4):437-45
10445058
Ear Hear. 2006 Feb;27(1):1-19
16446561
Ann Otol Rhinol Laryngol. 2002 Sep;111(9):842-9
12296342
Acta Otolaryngol. 2004 Mar;124(2):124-9
15072413
Hear Res. 1998 Apr;118(1-2):1-12
9606057