Isolated nasal septum necrosis caused by Aspergillus flavus in an immunocompromised child.
Nontraumatic isolated nasal septal aspergillosis in the absence of sinusitis is a rare but serious infection in immunocompromised patients. Adequate management requires early diagnosis, prompt empiric antifungal therapy, and surgical debridement to prevent progression of life-threatening complications. With the increasing population of immunocompromised children, it is essential for timely management that clinicians have a high index of suspicion for this unusual presentation of aspergillosis.
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.
Fouzia
F
Naeem
Jeffrey E
JE
Rubnitz
Hana
H
Hakim
D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D001231:Aspergillus flavus / Q000302:isolation & purification*; D002675:Child, Preschool; D003646:Debridement; D042241:Early Diagnosis; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009300:Nasal Septum / Q000473:pathology*; D009336:Necrosis / Q000473:pathology*
D000935:Antifungal Agents
Clin Microbiol Infect. 2010 Aug;16(8):1197-203
20156215
Clin Infect Dis. 2005 Jun 15;40(12):1762-9
15909264
Otolaryngol Head Neck Surg. 2007 Mar;136(3):506-7
17321893
Clin Infect Dis. 2008 Feb 1;46(3):327-60
18177225
N Engl J Med. 1997 Jul 24;337(4):275-6
9229692
AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1878-9
17905891
CMAJ. 1988 May 15;138(10):927-8
3284628
Pediatr Blood Cancer. 2007 Jan;48(1):28-34
16395687
Am J Rhinol. 2000 Jan-Feb;14(1):39-43
10711331
Clin Infect Dis. 2002 Apr 1;34(7):939-43
11880959