Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation.
Differentiation-inducing factor-1 and -2 (DIF-1 and DIF-2) are small lipophilic signal molecules that control both cell differentiation and chemotaxis in the cellular slime mold Dictyostelium discoideum. In this study, we examined the effects of four amide derivatives of DIF-1 on stalk cell differentiation and chemotaxis. The DIF derivatives differentially affected cell differentiation and chemotaxis, suggesting the possible existence of at least three receptors for DIFs: one receptor responsible for stalk cell induction, and two receptors responsible for chemotaxis modulation. Furthermore, our results indicate that DIF derivatives can be utilized to analyze the DIF-signaling pathways.
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.
Hidekazu
H
Kuwayama
Haruhisa
H
Kikuchi
Yoshiteru
Y
Oshima
Yuzuru
Y
Kubohara
D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D002633:Chemotaxis / Q000187:drug effects*; D004023:Dictyostelium / Q000166:cytology* / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D015800:Protozoan Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
D000577:Amides; D015800:Protozoan Proteins