Pervasive roles of microRNAs in cardiovascular biology.
First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.
Eric M
EM
Small
Eric N
EN
Olson
D000818:Animals; D001808:Blood Vessels / Q000254:growth & development / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D002319:Cardiovascular System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation
D035683:MicroRNAs
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18255-60
17108080
Circ Res. 2010 Jul 9;107(1):138-43
20489163
Cell Death Differ. 2009 Dec;16(12):1590-8
19816508
Nat Genet. 2006 Dec;38(12):1452-6
17072316
Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1118-26
20378849
J Am Coll Cardiol. 2002 Jun 19;39(12):1890-900
12084585
Nature. 2009 Aug 6;460(7256):705-10
19578358
Curr Biol. 2010 Jul 27;20(14):1321-5
20579881
Circ Res. 2010 Nov 26;107(11):1336-44
20947829
Dev Cell. 2009 Nov;17(5):662-73
19922871
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12103-8
19574461
Development. 2007 Aug;134(16):2913-23
17626061
Clin Chem. 2009 Nov;55(11):1944-9
19696117
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3300-5
17360642
Nature. 2008 Dec 18;456(7224):980-4
19043405
Dev Cell. 2008 Jun;14(6):843-53
18539114
J Clin Invest. 2007 Sep;117(9):2369-76
17786230
J Clin Invest. 2009 Sep;119(9):2634-47
19690389
Cell. 2007 Apr 20;129(2):303-17
17397913
Circ Res. 2010 Sep 3;107(5):677-84
20595655
Genes Dev. 2009 Sep 15;23(18):2166-78
19720868
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2750-5
17293455
Sci Signal. 2010 Apr 13;3(117):ra29
20388916
Cardiovasc Res. 2009 Apr 1;82(1):21-9
19147652
Blood. 2008 Jan 15;111(2):588-95
17906079
J Heart Lung Transplant. 2008 Dec;27(12):1282-5
19059107
Circ Res. 2007 Jun 8;100(11):1579-88
17478730
Genes Dev. 2008 Dec 1;22(23):3242-54
19015276
BMC Genomics. 2010 Apr 06;11:224
20370903
Circulation. 2010 Mar 2;121(8):1022-32
20194875
Nat Med. 2007 Apr;13(4):486-91
17401374
J Exp Med. 2010 Jul 5;207(7):1351-8
20513743
Physiol Genomics. 2007 Nov 14;31(3):367-73
17712037
Circ Res. 2009 Jul 17;105(2):158-66
19542014
Cell. 2009 May 15;137(4):647-58
19409607
Nat Rev Genet. 2009 Aug;10(8):578-85
19609263
J Biol Chem. 2008 Jul 18;283(29):20045-52
18458081
Circulation. 2009 Mar 10;119(9):1263-71
19237659
Cell Stem Cell. 2008 Mar 6;2(3):219-29
18371447
Circ Res. 2009 Sep 11;105(6):585-94
19679836
Genes Dev. 2010 Aug 1;24(15):1614-9
20679397
Circulation. 2007 Jul 17;116(3):258-67
17606841
J Cell Mol Med. 2009 Aug;13(8A):1577-85
19120690
Am J Hum Genet. 2007 Aug;81(2):405-13
17668390
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20844-9
18093911
Physiol Genomics. 2010 Aug;42(3):420-6
20484156
Dev Cell. 2008 Aug;15(2):261-71
18694565
Nature. 2008 Feb 21;451(7181):943-8
18288184
Dev Cell. 2010 Apr 20;18(4):510-25
20412767
Nat Rev Cardiol. 2009 Jun;6(6):419-29
19434076
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17830-5
19004786
Curr Opin Hematol. 2010 May;17(3):155-62
20216213
N Engl J Med. 2008 Mar 27;358(13):1370-80
18367740
Nat Biotechnol. 2007 Dec;25(12):1457-67
18026085
Sci Signal. 2009 Dec 08;2(100):ra81
19996457
Science. 2007 Apr 27;316(5824):575-9
17379774
Cell. 2009 Jan 23;136(2):215-33
19167326
Nat Rev Genet. 2008 Feb;9(2):102-14
18197166
Biochem Biophys Res Commun. 2010 Jun 11;396(4):978-82
20470754
Science. 2010 Jan 8;327(5962):198-201
19965718
Development. 2008 Dec;135(24):3989-93
18987025
Nature. 2005 Jul 14;436(7048):214-20
15951802
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1516-21
18227515
Nature. 2008 Feb 28;451(7182):1125-9
18278031
Development. 2010 Jun;137(11):1887-96
20460367
Circ Res. 2008 Oct 24;103(9):919-28
18948630
Dev Cell. 2008 Aug;15(2):272-84
18694566
Cell. 1998 Apr 17;93(2):215-28
9568714
J Cardiovasc Transl Res. 2010 Jun;3(3):212-8
20560042
Science. 2009 Jun 26;324(5935):1710-3
19460962
J Clin Invest. 2009 Sep;119(9):2772-86
19726871
Genes Dev. 2007 Aug 15;21(16):1999-2004
17626790
Nat Med. 2007 May;13(5):613-8
17468766
Curr Biol. 2010 Jul 27;20(14):R598-600
20656201
Circ Res. 2009 Mar 27;104(6):724-32
19325160
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13027-32
18723672
J Clin Invest. 2010 Nov;120(11):3912-6
20978354
Science. 2007 Oct 12;318(5848):271-4
17761850
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2111-6
18256189
J Cell Physiol. 2007 Aug;212(2):285-92
17516552
Cell. 2004 Jan 23;116(2):281-97
14744438
Nature. 2010 Apr 22;464(7292):1196-200
20364122
Nat Genet. 2006 Jul;38(7):813-8
16751773
Nature. 2008 Apr 17;452(7189):896-9
18368051
Science. 2010 Jun 18;328(5985):1566-9
20466882
Circ Res. 2009 Apr 10;104(7):879-86
19265035
Nat Methods. 2007 Sep;4(9):721-6
17694064
Curr Biol. 2010 Feb 23;20(4):367-73
20096582
Nucleic Acids Res. 2008 Sep;36(16):5232-41
18684991
Genes Dev. 2010 Aug 1;24(15):1620-33
20679398
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4218-23
20142475