Contribution of platelets to tumour metastasis.
Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Laurie J
LJ
Gay
Brunhilde
B
Felding-Habermann
D014408:Biomarkers, Tumor / Q000378:metabolism; D001792:Blood Platelets / Q000473:pathology*; D002199:Capillary Permeability; D002470:Cell Survival; D006801:Humans; D009362:Neoplasm Metastasis / Q000503:physiopathology* / Q000517:prevention & control; D009360:Neoplastic Cells, Circulating; D009389:Neovascularization, Pathologic; D015539:Platelet Activation; D010975:Platelet Aggregation Inhibitors
D014408:Biomarkers, Tumor; D010975:Platelet Aggregation Inhibitors
J Thromb Haemost. 2006 Mar;4(3):519-26
16405520
Gynecol Oncol. 2006 Dec;103(3):902-5
16828847
Am J Pathol. 1999 Aug;155(2):461-72
10433939
J Clin Invest. 1988 Apr;81(4):1012-9
3280598
Microcirculation. 2010 Jan;17(1):39-46
20141599
J Clin Oncol. 2009 Oct 10;27(29):4821-6
19752337
J Clin Oncol. 2007 Dec 1;25(34):5490-505
17968019
Blood. 1993 Aug 15;82(4):1184-91
8353283
Cancer Metastasis Rev. 2007 Dec;26(3-4):359-71
17721743
N Engl J Med. 2008 Sep 18;359(12):1261-70
18799560
Semin Thromb Hemost. 2009 Oct;35(7):644-53
20013531
Cancer Res. 2009 Oct 1;69(19):7775-83
19738039
Blood. 2007 Jul 1;110(1):133-41
17371949
Thromb Haemost. 2008 Jan;99(1):27-37
18217131
Semin Thromb Hemost. 2007 Oct;33(7):643-52
18000790
Nat Rev Cancer. 2010 Jun;10(6):415-24
20495575
Thromb Res. 2007;120 Suppl 2:S7-12
18023716
Clin Exp Metastasis. 2010 Apr;27(4):217-31
20225083
Transfusion. 2006 Jul;46(7):1199-209
16836568
Semin Thromb Hemost. 1992;18(4):392-415
1470927
Nat Rev Drug Discov. 2009 Apr;8(4):297-307
19300460
Blood. 2008 Feb 1;111(3):1201-7
17914028
Nature. 1997 Sep 11;389(6647):183-6
9296496
J Leukoc Biol. 2008 Jan;83(1):1-12
17906117
Cancer Res. 1991 Sep 1;51(17):4549-56
1873799
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14205-10
14612570
Cancer Res. 2009 Jul 15;69(14):5623-6
19584268
J Urol. 2006 Mar;175(3 Pt 1):859-63
16469566
J Clin Invest. 2004 Dec;114(12):1691-3
15599391
Nat Med. 1998 Aug;4(8):923-8
9701244
Cancer Cell. 2006 Mar;9(3):225-38
16530706
Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1853-8
11172040
Cancer Res. 2007 Jul 1;67(13):6221-9
17616679
Blood. 2003 Mar 1;101(5):1970-6
12584142
Neuro Oncol. 2007 Jul;9(3):335-42
17504931
Cancer Cell. 2006 Nov;10(5):355-62
17097558
Blood. 2000 Nov 15;96(10):3302-9
11071621
Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5341-7
17855648
J Surg Res. 1975 Feb;18(2):137-61
166253
Int J Cancer. 1984 Apr 15;33(4):519-23
6368410
J Immunol. 1992 Jul 15;149(2):636-42
1378073
Cancer Metastasis Rev. 2006 Mar;25(1):9-34
16680569
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2193-8
11854515
Microcirculation. 2009 Jan;16(1):43-57
18720226
Blood. 2010 Jun 3;115(22):4605-13
20086246
Blood. 2008 Feb 1;111(3):981-6
18223171
Microcirculation. 2009 Jan;16(1):17-30
18979279
Cancer Res. 2009 Oct 1;69(19):7884-92
19773434
Annu Rev Biomed Eng. 2009;11:177-202
19413512
Am J Physiol Cell Physiol. 2008 Apr;294(4):C907-16
18234849
Thromb Res. 2007;120 Suppl 2:S22-8
18023710
Blood. 2009 Nov 12;114(20):4583-91
19779041
Cancer Res. 2004 Dec 1;64(23):8613-9
15574768
J Thromb Haemost. 2009 Oct;7(10):1713-7
19624454
Oncogene. 2008 Jan 10;27(3):264-73
17637752
Thromb Res. 2008;122(5):604-9
18262600
Thromb Haemost. 2003 Jun;89(6):1098-106
12783124
J Thromb Haemost. 2009 Nov;7(11):1759-66
19691483
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):663-8
9012841
Int J Cancer. 2009 Apr 15;124(8):1773-7
19101987
Annu Rev Cell Dev Biol. 2005;21:381-410
16212500
J Clin Oncol. 2009 Oct 10;27(29):4839-47
19720906
Nat Med. 2006 May;12(5):557-67
16648859
Nat Rev Mol Cell Biol. 2010 Apr;11(4):288-300
20308986
Br J Pharmacol. 2004 Dec;143(7):819-26
15492016
Blood. 2000 Sep 1;96(5):1789-97
10961878
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10666-71
19541645
Blood. 2007 Sep 15;110(6):1723-9
17496204
J Biol Chem. 1996 Mar 8;271(10):5892-900
8621462
Blood. 2008 Feb 1;111(3):1227-33
17962514
Lancet. 2009 Apr 11;373(9671):1301-9
19328542
Int J Cancer. 2005 Feb 20;113(5):752-60
15499615
J Thromb Haemost. 2007 Mar;5(3):520-7
17166244
J Exp Med. 2009 Aug 31;206(9):1913-27
19667060
J Clin Invest. 2004 Dec;114(12):1714-25
15599396
Thromb Res. 2010 Apr;125 Suppl 1:S46-8
20153515
Clin Cancer Res. 2000 Jan;6(1):166-71
10656446
Trends Mol Med. 2004 May;10(5):232-8
15121050
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17210-5
15563590
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9325-30
9689079
Semin Thromb Hemost. 2008 Mar;34(2):154-60
18645920
N Engl J Med. 2007 Dec 13;357(24):2482-94
18077812
Expert Rev Anticancer Ther. 2008 Aug;8(8):1247-55
18699763
Eur Urol. 2009 Sep;56(3):479-84
18585841
J Natl Cancer Inst. 1971 Mar;46(3):493-504
4100699
Thromb Haemost. 2008 Oct;100(4):663-9
18841290
Semin Thromb Hemost. 2004 Feb;30(1):95-108
15034801
Immunol Rev. 2007 Aug;218:126-34
17624949
Thromb Haemost. 2003 Sep;90(3):549-54
12958625
J Thromb Haemost. 2003 Dec;1(12):2463-5
14675077
Nat Rev Cancer. 2009 Apr;9(4):239-52
19279573
Prostaglandins Leukot Essent Fatty Acids. 1995 Jul;53(1):65-8
7675825
Blood. 2004 Mar 15;103(6):2096-104
14630798
Clin Cancer Res. 2008 Jun 15;14(12):3942-7
18559616
Cancer Res. 2002 Dec 1;62(23):6966-72
12460914
Mayo Clin Proc. 2010 Sep;85(9):838-54
20810794
Cancer Res. 1989 Feb 1;49(3):537-41
2910473
Blood. 2010 Apr 29;115(17):3427-36
20194899
Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L258-67
12626332
Cancer Res. 2006 Nov 15;66(22):11013-20
17108140
Cancer Res. 2005 Nov 15;65(22):10324-9
16288021
Lancet Oncol. 2004 Nov;5(11):655-63
15522652
Exp Hematol. 2002 May;30(5):450-9
12031651
Int J Cancer. 2010 Jul 15;127(2):332-44
19937793
Blood. 2000 Nov 15;96(10):3431-8
11071638
Cancer Res. 2010 Jun 1;70(11):4327-34
20501851
Proc Natl Acad Sci U S A. 1968 Sep;61(1):46-52
5246932
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11832-6
1465406
Circ Res. 2007 Jan 5;100(1):27-40
17204662
Br J Pharmacol. 2010 Oct;161(4):755-67
20636392
Circ Res. 2007 Jun 22;100(12):1673-85
17585075
Thromb Res. 2010 Apr;125 Suppl 2:S36-8
20434002
Nat Rev Cancer. 2009 Apr;9(4):274-84
19308067
Lancet. 1998 Nov 28;352(9142):1775-7
9848370
Urol Int. 2007;79(2):111-6
17851278
J Cell Sci. 2010 May 15;123(Pt 10):1603-11
20445011
Exp Cell Res. 1994 Jan;210(1):1-9
8269984
Pathophysiol Haemost Thromb. 2003;33 Suppl 1:56-8
12955006
Cancer Res. 2008 Sep 1;68(17):7219-27
18757438
Blood. 1984 Jan;63(1):55-63
6360248
N Engl J Med. 1971 Nov 18;285(21):1182-6
4938153
Clin Exp Metastasis. 1989 Mar-Apr;7(2):169-74
2537694
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):855-60
16418262
Nat Rev Cancer. 2010 Jan;10(1):9-22
20029421
Blood. 2005 Jan 1;105(1):178-85
15367435
Invest Ophthalmol Vis Sci. 2005 Jun;46(6):1927-33
15914605
Blood. 2009 Mar 19;113(12):2835-42
19036702
Lab Invest. 1985 Oct;53(4):470-8
4046557
Adv Cancer Res. 2010;106:91-111
20399957
Am J Surg. 2005 Mar;189(3):278-82
15792750
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9482-7
12874388
J Invest Dermatol. 2010 Feb;130(2):576-86
19727118
Thromb Haemost. 2007 Jan;97(1):119-23
17200778
Lancet. 1995 Oct 14;346(8981):1004-5
7475548
Thromb Haemost. 1990 Dec 28;64(4):501-5
1964750
Am J Pathol. 1991 Jan;138(1):213-21
1987767
Am J Pathol. 2008 Jan;172(1):1-7
18079440
Nature. 2008 Feb 21;451(7181):914-8
18288180
J Clin Invest. 1991 Jan;87(1):229-36
1845869
Nat Med. 2006 Aug;12(8):895-904
16892035
Semin Cancer Biol. 2010 Jun;20(3):169-77
20452433
Clin Exp Metastasis. 2010;27(1):25-34
19916050
Nat Rev Cancer. 2002 Aug;2(8):563-72
12154349
Proc Natl Acad Sci U S A. 2007 May 22;104(21):9024-8
17494758
Semin Thromb Hemost. 2007 Oct;33(7):712-21
18000800
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):216-20
15615851
Thromb Res. 2007;120 Suppl 2:S64-70
18023715
Am J Pathol. 2009 Nov;175(5):2159-70
19815705
Thromb Res. 2010 Apr;125 Suppl 2:S84-8
20434014
Blood. 2005 Oct 15;106(8):2671-9
15972454
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3352-7
11248082
Med Res Rev. 2009 Nov;29(6):903-53
19434693
Blood. 2004 Jul 15;104(2):397-401
15031212
Cancer Res. 1999 Mar 15;59(6):1295-300
10096562
Nature. 2001 Sep 6;413(6851):74-8
11544528
Blood. 2004 Nov 1;104(9):2746-51
15265791
Semin Thromb Hemost. 2006 Apr;32 Suppl 1:61-8
16673267
Cancer Res. 2004 Apr 15;64(8):2743-50
15087389
Nat Rev Cancer. 2009 Apr;9(4):285-93
19308068
Eur J Cancer. 2003 Jan;39(2):184-91
12509950
Am J Pathol. 2009 Oct;175(4):1699-708
19729481
Cancer Res. 2008 Aug 15;68(16):6851-8
18701510
Thromb Haemost. 2009 Aug;102(2):258-67
19652876
Cell. 2006 Nov 17;127(4):679-95
17110329
Blood Coagul Fibrinolysis. 2001 Jan;12(1):43-50
11229826
PLoS One. 2010 Mar 17;5(3):e9741
20305819
Cancer Res. 2008 Jun 1;68(11):4296-302
18519689
Cancer Sci. 2010 Nov;101(11):2411-6
20731664