Subsyndromal states in bipolar disorder.
BACKGROUND
Despite adequate treatment, patients with bipolar disorder suffer from subsyndromal symptoms. This study has been done to see the association of subsyndromal symptoms with age of onset, duration of illness, duration of episodes, and number of episodes.


OBJECTIVE
To know the prevalence of subsyndromal symptoms and their relationship with age of onset, total duration of illness, number of episodes, and duration of episodes in patients with bipolar disorder in remission.


METHODS
The study was cross sectional and hospital based. One hundred patients, aged between 18 and 65 years, diagnosed as bipolar disorder according to Research Diagnostic Criteria of ICD-10, and with good compliance with the prophylactic medications, score of ≤5 on Beck's Mania Rating Scale (BMRS) and score ≤8 on Hamilton Depression Rating Scale (HDRS) were recruited by the purposive sampling method. Descriptive statistics were used to describe various sample characteristics. Group differences for categorical variables were examined with the chi-square test, whereas an independent 't' test was used for continuous variables.


RESULTS
The most common manic symptom was a decrease in sleep (49%), followed by an increase in verbal activity (39%), hostility (37%), and increase in motor activity (33.33%). The subsyndromal manic group had a lower age of onset (58.8%), males (82.4%), unemployed (23.5%), educated (80.4%). There was no significant difference between with and without subsyndromal mania groups with respect to age, age of onset, duration of illness, number of episode, and average duration of episode.


CONCLUSIONS
Subsyndromal manic symptoms are prevalent and have no relationship with current age, age of onset of illness, duration of illness, number of episode, and average duration of illness in patient with bipolar disorder in remission.
Department of Psychiatry, JSS Medical College Hospital, Mysore, India.
Dushad
D
Ram
Daya
D
Ram
Acta Psychiatr Scand Suppl. 1986;326:1-37
3458353
Biol Psychiatry. 2000 Sep 15;48(6):445-57
11018218
Br J Psychiatry. 1985 Oct;147:434-7
4075034
Arch Gen Psychiatry. 1990 Jul;47(7):665-71
2113802
Acta Psychiatr Scand Suppl. 1987;334:1-100
2887090
Br J Psychiatry. 1990 Apr;156:508-14
2078211
Am J Psychiatry. 1987 Mar;144(3):367-9
3103474
Compr Psychiatry. 1989 Mar-Apr;30(2):121-7
2920547
J Affect Disord. 1999 Apr;53(1):57-65
10363667
J Psychiatr Res. 1975 Apr;12(1):37-50
1142308
Compr Psychiatry. 1996 Sep-Oct;37(5):362-7
8879911
Psychopathology. 2010;43(1):1-7
19893338
Psychol Med. 1995 Nov;25(6):1171-80
8637947
Indian J Psychiatry. 2001 Jul;43(3):199-205
21407855
Am J Psychiatry. 2000 Feb;157(2):220-8
10671390
Am J Psychiatry. 1979 Nov;136(11):1420-3
495794
J Clin Psychiatry. 2004;65 Suppl 10:24-7
15242329
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
14399272
Bipolar Disord. 2003 Oct;5(5):349-55
14525555
Arch Gen Psychiatry. 1974 Apr;30(4):441-3
4815550
Br J Psychiatry. 1972 May;120(558):523-30
5041532
Psychol Med. 1999 Jan;29(1):47-61
10077293
J Affect Disord. 1999 Jul;54(1-2):87-96
10403151
Soc Psychiatry Psychiatr Epidemiol. 2009 Jul;44(7):515-22
19011720
Arch Gen Psychiatry. 1978 Nov;35(11):1351-4
708196
Arch Gen Psychiatry. 1992 May;49(5):371-6
1586272
J Affect Disord. 1992 Jan;24(1):35-41
1545043