Recognition of herpesviruses by the innate immune system.
Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses that replicate in the nucleus, are initially recognized during cellular infection. Surprisingly, this involves multiple PRRs both on the cell surface and within endosomes and the cytosol. In this article we describe recent advances in our understanding of innate detection of herpesviruses, how this innate detection translates into anti-herpesvirus host defence, and how the viruses seek to evade this innate detection to establish persistent infections.
Department of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK-8000 Aarhus C, Denmark. srp@microbiology.au.dk
Søren R
SR
Paludan
Andrew G
AG
Bowie
Kristy A
KA
Horan
Katherine A
KA
Fitzgerald
D004279:DNA, Viral / Q000276:immunology; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D012367:RNA, Viral / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology
D004279:DNA, Viral; D012367:RNA, Viral; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors
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