Bioinert surface to protein adsorption with higher generation of dendrimer SAMs.
Interactions between proteins and biomaterial surfaces correlate with many important phenomena in biological systems. Such interactions have been used to develop various artificial biomaterials and applications, in which regulation of non-specific protein adsorption has been achieved with bioinert properties. In this research, we investigated the protein adsorption behavior of polymer brushes of dendrimer self-assembled monolayers (SAMs) with other generations. The surface adsorption properties of proteins with different pI values were examined on gold substrates modified with poly(amidoamine) dendrimer SAMs. The amount of fibrinogen adsorption was greater than that of lysozyme, potentially because of the surface electric charge. However, as the generations increased, protein adsorption decreased regardless of the surface charge, suggesting that protein adsorption was also affected by density of terminal group.
School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan.
Erino
E
Matsumoto
Tomohiro
T
Fukuda
Yoshiko
Y
Miura
D000327:Adsorption; D050091:Dendrimers / Q000737:chemistry*; D008954:Models, Biological; D011485:Protein Binding; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
D050091:Dendrimers