Leptin and adiponectin in obese and non-obese subjects with asthma.
OBJECTIVE
To understand the role of leptin and adiponectin in obese asthmatics.


METHODS
We compared serum leptin, adiponectin and sputum leptin levels in 44 non-obese and 44 obese subjects.


RESULTS
We found higher serum leptin (P < 0.0001) and lower adiponectin (P = 0.0002) levels in obese asthmatics. Sputum leptin was correlated with body mass index (BMI; r = 0.34, P = 0.03) and serum leptin (r = 0.43, P = 0.005); however, this last correlation was not significant after adjusting for BMI (r = 0.26, P = 0.11).


CONCLUSIONS
Airway inflammation in obese asthmatics may present a different pattern involving leptin. Sputum leptin levels may partially originate from systemic circulation, with other contributing mechanisms.
Centre de Recherche Clinique, l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, QC, Canada.
Andréa
A
Lessard
Julie
J
St-Laurent
Hélène
H
Turcotte
Louis-Philippe
LP
Boulet
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001249:Asthma / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D013183:Sputum / Q000737:chemistry* / Q000378:metabolism
D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin