Frequency of the mdr-1 C>T gene polymorphism in patients with COPD.
OBJECTIVE
The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease.


METHODS
DNA samples from 41 patients with chronic obstructive pulmonary disease and 50 healthy control participants were used to compare MDR-1 gene profiles. Genotyping assays were performed using the StripAssay technique that is based on reverse-hybridization.


RESULTS
The T allele polymorphism in the MDR-1 gene located at position 3435 in exon 26 was shown to correlate with chronic obstructive pulmonary disease.


CONCLUSIONS
These preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with chronic obstructive pulmonary disease.
Department of Chest Diseases, Medical Faculty, Cumhuriyet University, Sivas, Turkey.
Omer Tamer
OT
Dogan
Nurkay
N
Katrancioglu
Ouz
O
Karahan
Gülizar Canan
GC
Sanli
Ali
A
Zorlu
Sinasi
S
Manduz
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D019450:Genes, MDR / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1
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