Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy.
Monika M
MM
Pichler
Claudia
C
Bodner
Carina
C
Fischer
Alexander J
AJ
Deutsch
Karin
K
Hiden
Christine
C
Beham-Schmid
Werner
W
Linkesch
Christian
C
Guelly
Heinz
H
Sill
Albert
A
Wölfler
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000235:genetics*; D024182:Uniparental Disomy; D055815:Young Adult
C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase