Polymorphisms in integrin genes and lymphoma risk.
Immune deficiency is one of the best characterized and strongest known risk factors for non-Hodgkin lymphoma (NHL). We studied the association between single nucleotide polymorphisms (SNPs) in integrin genes that are important components in human innate immunity and the risk of NHL in a population-based case-control study of women in Connecticut, USA. A total of 373 tag SNPs in 33 gene regions were included in the analysis of 448 cases and 525 controls. The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma. Two gene regions (ADAM19 (P=0.009) and ICAM3 (P=0.009)) displayed global associations with lymphoma risk at the P<0.01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations.
Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7240, USA.
Min
M
Shen
Tongzhang
T
Zheng
Qing
Q
Lan
Yawei
Y
Zhang
H Dean
HD
Hosgood
Shelia H
SH
Zahm
Theodore R
TR
Holford
Brian
B
Leaderer
Meredith
M
Yeager
Jeff
J
Yuenger
Stephen
S
Chanock
Nathaniel
N
Rothman
D051722:ADAM Proteins / Q000235:genetics*; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics*; D003237:Connecticut / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D011982:Receptors, Prostaglandin / Q000235:genetics*; D012307:Risk Factors
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; C483616:ICAM3 protein, human; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D051722:ADAM Proteins; C411902:ADAM19 protein, human; C036293:prostaglandin D2 receptor
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17337643
Cancer Causes Control. 2003 Sep;14(7):687-94
14575367
Cancer Sci. 2007 May;98(5):621-8
17355265
Parasitol Res. 2009 Jan;104(2):481-3
18946680
Curr Opin Immunol. 2007 Feb;19(1):1-3
17157490
J Clin Pathol. 1994 Feb;47(2):143-7
8132828
Cell. 2002 Sep 20;110(6):673-87
12297042
Curr Pharm Des. 2009;15(20):2336-48
19601835