Evaluation of a screening tool for bleeding disorders in a US multisite cohort of women with menorrhagia.
OBJECTIVE
The purpose of this study was to determine the usefulness of a simple screening tool for bleeding disorders in a multisite population of women with menorrhagia.


METHODS
Women with menorrhagia between the ages of 18 and 50 years from 6 geographically diverse US centers underwent hemostatic testing for bleeding disorders, complete blood cell count, and ferritin. A questionnaire that contained all elements of the 8-question screening tool was administered. Sensitivity of the screening tool, a screening tool with a pictorial blood assessment chart (PBAC) score of >185, and a screening tool with serum ferritin were calculated for hemostatic disorders.


RESULTS
Two hundred and seventeen women who were identified with a PBAC score of ≥100 participated in the study. The sensitivity of the screening tool was 89% for hemostatic defects, and sensitivity increased to 93% and 95% with a serum ferritin level of ≤20 ng/mL and a PBAC score of >185, respectively.


CONCLUSIONS
This study confirms the usefulness of a short screening tool for the stratification of women with menorrhagia for hemostatic evaluation.
Division of Hematology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. philipp@umdnj.edu
Claire S
CS
Philipp
Ambarina
A
Faiz
John A
JA
Heit
Peter A
PA
Kouides
Andrea
A
Lukes
Sidney F
SF
Stein
Vanessa
V
Byams
Connie H
CH
Miller
Roshni
R
Kulkarni
D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006474:Hemorrhagic Disorders / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008403:Mass Screening; D008595:Menorrhagia / Q000209:etiology*; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014481:United States; D055815:Young Adult
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