Ongoing pain in the MIA model of osteoarthritis.
Osteoarthritis (OA) is a chronic pain condition characterized by pain during joint use as well as pain at rest (i.e., ongoing pain). Although injection of monosodium iodoacetate (MIA) into the intra-articular space of the rodent knee is a well established model of OA pain that is characterized by changes in weight bearing and hypersensitivity to tactile and thermal stimuli, it is not known if this procedure elicits ongoing pain. Further, the time-course and possible underlying mechanisms of these components of pain remain poorly understood. In these studies, we demonstrated the presence of ongoing pain in addition to changes in weight bearing and evoked hypersensitivity. Twenty-eight days following MIA injection, spinal clonidine blocked changes in weight bearing and thermal hypersensitivity and produced place preference indicating that MIA induces ongoing and evoked pain. These findings demonstrate the presence of ongoing pain in this model that is present at a late-time point after MIA allowing for mechanistic investigation.
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Ping
P
Liu
Alec
A
Okun
Jiyang
J
Ren
Rui-chen
RC
Guo
Michael H
MH
Ossipov
Jennifer
J
Xie
Tamara
T
King
Frank
F
Porreca
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D007461:Iodoacetates / Q000633:toxicity*; D008297:Male; D010003:Osteoarthritis / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology*; D010146:Pain / Q000209:etiology* / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D007461:Iodoacetates
Stereotact Funct Neurosurg. 2000;75(4):167-75
11910210
Curr Med Res Opin. 2004 Sep;20(9):1455-8
15383194
Semin Arthritis Rheum. 2005 Aug;35(1 Suppl 1):1-10
16084227
Pain. 1988 Jan;32(1):77-88
3340425
Neurosci Lett. 2004 Nov 11;370(2-3):236-40
15488329
Curr Opin Rheumatol. 2009 Sep;21(5):507-12
19633560
Osteoarthritis Cartilage. 2008 Apr;16(4):415-22
18296075
Pain. 2007 Apr;128(3):272-282
17276007
Pain. 2005 Apr;114(3):339-346
15777859
Eur J Pharmacol. 2009 Jun 24;613(1-3):39-45
19376109
Curr Med Res Opin. 2004;20 Suppl 2:S29-31
15563744
Ann N Y Acad Sci. 2010 Mar;1192:230-7
20392241
Osteoarthritis Cartilage. 2004 Mar;12(3):253-5
14972343
J Neurophysiol. 1988 Dec;60(6):2180-95
3236065
J Neurophysiol. 1985 Nov;54(5):1109-22
4078610
Eur J Pain. 2009 Sep;13(8):786-93
18955000
Pain. 2009 Mar;142(1-2):27-35
19135797
J Pain. 2006 Jul;7(7):513-20
16814690
Science. 1976 Jun 25;192(4246):1357-8
1273597
Nat Neurosci. 2009 Nov;12(11):1364-6
19783992
Osteoarthritis Cartilage. 2006 Nov;14(11):1155-62
16740398
Pain. 2004 Nov;112(1-2):83-93
15494188
Mol Pain. 2008 Oct 25;4:47
18950528
Lancet. 2005 Mar 12-18;365(9463):965-73
15766999
Arthritis Rheum. 2009 Sep 15;61(9):1226-34
19714588
Rheum Dis Clin North Am. 2003 Nov;29(4):687-716
14603578
Arthritis Res Ther. 2009;11(3):227
19519925
Curr Med Res Opin. 2004;20 Suppl 2:S13-9
15563742