The incidence of venous thromboembolism and practice of deep venous thrombosis prophylaxis in hospitalized cirrhotic patients.
BACKGROUND
Cirrhotic patients are characterized by a decreased synthesis of coagulation and anticoagulation factors. The coagulopathy of cirrhotic patients is considered to be auto-anticoagulation. Our aim was to determine the incidence and predictors of venous thromboembolism (VTE) and examine the practice of deep venous thrombosis (DVT) prophylaxis among hospitalized cirrhotic patients.


METHODS
A retrospective cohort study was performed in a tertiary teaching hospital. We included all adult patients admitted to the hospital with a diagnosis of liver cirrhosis from January 1, 2009 to December 31, 2009. We grouped our cohort patients in two groups, cirrhotic patients without VTE and cirrhotic with VTE.


RESULTS
Over one year, we included 226 cirrhotic patients, and the characteristics of both groups were similar regarding their clinical and laboratory parameters and their outcomes. Six patients (2.7%) developed VTE, and all of the VTEs were DVT. Hepatitis C was the most common (51%) underlying cause of liver cirrhosis, followed by hepatitis B (22%); 76% of the cirrhotic patients received neither pharmacological nor mechanical DVT prophylaxis.


CONCLUSIONS
Cirrhotic patients are at risk for developing VTE. The utilization of DVT prophylaxis was suboptimal.
Intensive Care Department, King Saud Bin Abdulaziz University for Health Science-King Abdulaziz Medical City, Riyadh, 11426, Saudi Arabia. aldawooda@hotmail.com.
Abdulaziz
A
Aldawood
Yaseen
Y
Arabi
Abdulrahman
A
Aljumah
Alawi
A
Alsaadi
Asgar
A
Rishu
Hasan
H
Aldorzi
Saad
S
Alqahtani
Mohammad
M
Alsultan
Afaf
A
Felemban
Am J Hematol. 2005 Jul;79(3):229-37
15981227
J Thromb Haemost. 2008 Jan;6(1):2-9
17892532
Saudi Med J. 2002 Sep;23(9):1070-3
12370714
Semin Liver Dis. 2002 Feb;22(1):83-96
11928081
World J Gastroenterol. 2006 Dec 28;12(48):7725-36
17203512
Int J Infect Dis. 2008 Sep;12(5):495-9
18400539
Hepatology. 2008 Apr;47(4):1384-93
18318436
Arch Intern Med. 2000 Mar 27;160(6):809-15
10737280
HPB (Oxford). 2009 Sep;11(6):459-64
19816608
Dig Dis Sci. 2008 Nov;53(11):3012-7
18443906
Intern Emerg Med. 2010 Feb;5(1):7-12
19714443
Chest. 2008 Jun;133(6 Suppl):381S-453S
18574271
Am J Gastroenterol. 2009 Jan;104(1):96-101
19098856
Chest. 2010 May;137(5):1145-9
20040609
Thromb Res. 1992 Oct 1;68(1):103-8
1448797
Hematol Oncol Clin North Am. 1992 Dec;6(6):1247-57
1333467
Trans R Soc Trop Med Hyg. 2009 Feb;103(2):132-6
18789464
J Hepatol. 2010 Mar;52(3):355-61
20132999
Hepatol Int. 2010 Jan 30;4(1):433-8
20305762
Am J Gastroenterol. 2006 Jul;101(7):1524-8; quiz 1680
16863556
Gastroenterology. 2009 Dec;137(6):2105-11
19706293
Hepatology. 2000 Feb;31(2):345-8
10655256
Ann Intern Med. 2006 May 16;144(10):705-14
16702586