Genome-wide association studies of atrial fibrillation: past, present, and future.
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF.
Department of Medicine I, University Hospital Munich, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany.
Moritz F
MF
Sinner
Patrick T
PT
Ellinor
Thomas
T
Meitinger
Emelia J
EJ
Benjamin
Stefan
S
Kääb
D001281:Atrial Fibrillation / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide
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