Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.
University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Center for Aging and Population Health, PA 15213, USA. newmana@edc.pitt.edu
Anne B
AB
Newman
Nancy W
NW
Glynn
Christopher A
CA
Taylor
Paola
P
Sebastiani
Thomas T
TT
Perls
Richard
R
Mayeux
Kaare
K
Christensen
Joseph M
JM
Zmuda
Sandra
S
Barral
Joseph H
JH
Lee
Eleanor M
EM
Simonsick
Jeremy D
JD
Walston
Anatoli I
AI
Yashin
Evan
E
Hadley
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D005684:Gait; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011597:Psychomotor Performance; D012107:Research Design
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