Terminal monosaccharide expression on amniotic glycoproteins as biomarkers of fetus maturity.
Glycotypes, particularly those that terminate with sialic acid and fucose are known to play a fundamental role in human development, during implantation, growth and differentiation of fetal tissues. The present review describes changes in the exposition of terminal sialic acid and fucose isoforms in the amniotic fluid glycoconjugates, α1-acid glycoprotein and fibronectin during critical stages of pregnancy, i.e. second and third trimester, perinatal period, delivery and post-date pregnancy. The distinct amniotic glycoforms are suggested to be implicated in regulatory processes to ensure homoeostasis during pregnancy and to protect the fetus. These may have the potential of becoming additional laboratory makers in obstetrics to monitor pregnancy.
Department of Chemistry and Immunochemistry, Wrocław University of Medicine, Bujwida 44a, 50-345 Wrocław, Poland. morczyk@immchem.am.wroc.pl
Magdalena
M
Orczyk-Pawiłowicz
Iwona
I
Kątnik-Prastowska
D000653:Amniotic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000737:chemistry / Q000378:metabolism*; D036861:Delivery, Obstetric; D005260:Female; D005333:Fetus / Q000737:chemistry / Q000378:metabolism*; D005643:Fucose / Q000737:chemistry / Q000378:metabolism; D005865:Gestational Age; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009005:Monosaccharides / Q000737:chemistry / Q000378:metabolism*; D019158:N-Acetylneuraminic Acid / Q000737:chemistry / Q000378:metabolism; D011247:Pregnancy; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism
D015415:Biomarkers; D006023:Glycoproteins; D009005:Monosaccharides; D020033:Protein Isoforms; D005643:Fucose; D019158:N-Acetylneuraminic Acid