Subcortical brain atrophy persists even in HAART-regulated HIV disease.
The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy.
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. beckerjt@upmc.edu
James T
JT
Becker
Joanne
J
Sanders
Sarah K
SK
Madsen
Ann
A
Ragin
Lawrence
L
Kingsley
Victoria
V
Maruca
Bruce
B
Cohen
Karl
K
Goodkin
Eileen
E
Martin
Eric N
EN
Miller
Ned
N
Sacktor
Jeffery R
JR
Alger
Peter B
PB
Barker
Priyanka
P
Saharan
Owen T
OT
Carmichael
Paul M
PM
Thompson
D000465:Algorithms; D023241:Antiretroviral Therapy, Highly Active; D001284:Atrophy; D002421:Caudate Nucleus / Q000473:pathology*; D015331:Cohort Studies; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000473:pathology*; D013997:Time Factors
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