Baseline observations from the POSSIBLE EU® study: characteristics of postmenopausal women receiving bone loss medications.
SUMMARY: Prospective Observational Scientific Study Investigating Bone Loss Experience in Europe (POSSIBLE EU®) is an ongoing longitudinal cohort study that utilises physician- and patient-reported measures to describe the characteristics and management of postmenopausal women on bone loss therapies. We report the study design and baseline characteristics of 3,402 women recruited from general practice across five European countries. PURPOSE: The POSSIBLE EU® is a study describing the characteristics and management of postmenopausal women receiving bone loss medications. METHODS: Between 2005 and 2008, general practitioners enrolled postmenopausal women initiating, switching or continuing treatment with bone loss treatment in France, Germany, Italy, Spain and the UK. Patients and physicians completed questionnaires at study entry and at 3-month intervals, for 1 year. RESULTS: Of 3,402 women enrolled (mean age 68.2 years [SD] 9.83), 96% were diagnosed with low bone mass; 55% of these using dual energy X-ray absorptiometry. Most women (92%) had comorbidities. Mean minimum T score (hip or spine) at diagnosis was -2.7 (SD 0.89; median -2.7 [interquartile range, -3.2, -2.2]) indicating low bone mineral density. Almost 40% of the women had prior fractures in adulthood, mostly non-vertebral, non-hip in nature, 30% of whom had at least two fractures and more than half experienced moderate/severe pain or fatigue. Bisphosphonates were the most common type of bone loss treatment prescribed in the 12 months preceding the study. CONCLUSIONS: POSSIBLE EU® characterises postmenopausal women with low bone mass, exhibiting a high rate of prevalent fracture, substantial bone fragility and overall comorbidity burden. Clinical strategies for managing osteoporosis in this population varied across the five participating European countries, reflecting their different guidelines, regulations and standards of care.
Nick
N
Freemantle
Cyrus
C
Cooper
Christian
C
Roux
Adolfo
A
Díez-Pérez
Francis
F
Guillemin
Bengt
B
Jonsson
Sergio
S
Ortolani
Johannes
J
Pfeilschifter
Rob
R
Horne
Shilpa
S
Kakad
Susan
S
Shepherd
Gerd
G
Möller
Anne
A
Marciniak
Luc
L
Martinez
Osteoporos Int. 2008 Aug;19(8):1219-23
18286217
Osteoporos Int. 2008 Apr;19(4):399-428
18266020
QJM. 2006 Aug;99(8):531-43
16861718
Health Policy. 1996 Jul;37(1):53-72
10158943
J Bone Miner Res. 2005 Oct;20(10):1813-9
16160738
Osteoporos Int. 2009 Mar;20(3):463-72
18607669
J Clin Endocrinol Metab. 2003 Aug;88(8):3482-6
12915621
Ann Rheum Dis. 2007 Jul;66(7):931-5
17314119
Osteoporos Int. 2007 May;18(5):629-39
17235664
Health Policy. 1990 Dec;16(3):199-208
10109801
Osteoporos Int. 2007 Jun;18(6):711-9
17245547