Laterality and temporal distribution of seizures in patients with bitemporal independent seizures during a trial of responsive neurostimulation.
We describe seizure laterality and temporal seizure patterns in six subjects with bilateral temporal lobe epilepsy (bTLE) implanted with bilateral hippocampal depth electrodes and the NeuroPace RNS™ system over 84 consecutive days. Seizures were disproportionate in laterality in three subjects and disproportionate in time for two subjects. Clustering of seizures did not clearly affect laterality. Some but not all subjects with bTLE displayed nonrandom temporal or lateral clustering of seizures.
Oregon Health & Science University, 3181 SW Sam Jackson Park Rd. CR120, Portland, OR 97239, United States. spencerd@ohsu.edu
David
D
Spencer
Ryder
R
Gwinn
Martin
M
Salinsky
Jean P
JP
O'Malley
D000328:Adult; D003627:Data Interpretation, Statistical; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012640:Seizures / Q000503:physiopathology* / Q000628:therapy*