The use of antidepressant drugs and the lifetime prevalence of major depressive disorders in Italy.
BACKGROUND
The increased use of antidepressant drugs (ADs) improved the response to the needs of care although some community surveys have shown that subjects without lifetime psychiatric diagnosis (anxiety/depression) used ADs.


OBJECTIVE
To evaluate the appropriateness and amount of prescription of psychotropic drugs in people with lifetime diagnosis of Major Depressive Disorder (MDD) by means of community survey with a semi-structured interview as a diagnostic instrument, administered by clinicians.


METHODS



METHODS
community survey.


METHODS
samples randomly drawn, after stratification from the adult population of municipal records.


METHODS
4.999 people were drawn in 7 centres of 6 Italian regions.


METHODS
questionnaire on psychotropic drug consumption, prescription, health services utilization; Structured Clinical Interview for DSM-IV modified (ANTAS); Training: interviewers were trained psychologists or medical doctors.


RESULTS
3.398 subjects were interviewed (68% of the recruited sample). The lifetime prevalence of DSM-IV MDD was 4.3% in males and 11.5% in females; antidepressant drugs were taken by 4.7% of subjects, 2.9% male and 5.9% female. 38% of males and 57% of females with lifetime diagnosis of MDD were taking ADs.


CONCLUSIONS
Compared with studies using lay interviewers and structured tools the prevalence of the MDD was quite lower; ADs use was higher and tallied well with the data regarding antidepressant sales in Italy; the correspondence between lifetime diagnosis of MDD and ADs use was closer.
Mauro Giovanni
MG
Carta
Eugenio
E
Aguglia
Alberto
A
Bocchetta
Matteo
M
Balestrieri
Filippo
F
Caraci
Massimo
M
Casacchia
Liliana
L
Dell'osso
Guido Di
GD
Sciascio
Filippo
F
Drago
Carlo
C
Faravelli
Maria Efisia
ME
Lecca
Maria Francesca
MF
Moro
Pier Luigi
PL
Morosini
Marcello
M
Nardini
Gabriella
G
Palumbo
Maria Carolina
MC
Hardoy
J Clin Psychiatry. 2005 Mar;66(3):360-9
15766303
Pharmacopsychiatry. 1988 Jan;21(1):15-8
3283783
J Affect Disord. 2002 Oct;72(1):53-9
12204317
Psychother Psychosom. 2006;75(3):170-6
16636632
Epidemiol Psichiatr Soc. 2003 Oct-Dec;12(4):287-92
14968486
J Clin Psychiatry. 2009;70 Suppl 6:32-7
19922742
Soc Psychiatry Psychiatr Epidemiol. 2004 Mar;39(3):171-6
14999448
Arch Gen Psychiatry. 1988 Dec;45(12):1069-77
2848472
Psychol Med. 2003 Feb;33(2):203-15
12622300
Soc Psychiatry Psychiatr Epidemiol. 2006 Nov;41(11):853-61
16915360
J Gen Intern Med. 1998 Feb;13(2):77-85
9502366
Soc Psychiatry Psychiatr Epidemiol. 2004 Nov;39(11):883-92
15549240