Reductive alkylation of indoles with alkynes and hydrosilanes under indium catalysis.
Under Indium catalysis, diverse alkylindoles were successfully prepared with a flexible combination of indoles and alkynes in the presence of hydrosilanes. In addition to the hydrosilane, carbon nucleophiles are also available. This new method generates alkylindoles in yields over 70% with a broad scope of functional group compatibility.
Department of Applied Chemistry, School of Science and Technology, Meiji University, Tama-ku, Kawasaki, Japan. tsuchimo@isc.meiji.ac.jp
Teruhisa
T
Tsuchimoto
Mitsutaka
M
Kanbara
D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007204:Indium / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*
D000480:Alkynes; D007211:Indoles; D012821:Silanes; D007204:Indium