The evolutionary origin and significance of menopause.
Contemporary women have long life expectancy (81 y, United States), especially relative to the age at menopause (51 y, United States). Menopause is a consequence of reproductive aging and follicular depletion (ovarian failure), yielding very low circulating estrogen serum concentrations and biologically disadvantageous metabolic alterations. Stated in terms of antagonistic pleiotropy, the ongoing hypoestrogenic endocrine environment, beneficial during lactation, results in acceleration of several age-related illnesses after menopause (ie, late postmenopausal osteoporosis, cardiovascular disease, and cognitive decline). Specifically, the similar hypoestrogenic hormonal milieu present during postpartum lactation provides biologic advantages (fitness) to both mother and newborn. These precepts of evolutionary medicine encourage a reassessment of hormone therapy, and on the basis of data presented the authors propose additional opportunities for disease prevention and morbidity reduction in postmenopausal women.
California Pacific Medical Center, 2100 Webster Street, Suite 320, San Francisco, CA 94115, USA. rickipol@pacbell.net
Ricki
R
Pollycove
Frederick
F
Naftolin
James A
JA
Simon
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D005075:Biological Evolution; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003072:Cognition Disorders / Q000453:epidemiology; D004967:Estrogens / Q000097:blood / Q000502:physiology; D005260:Female; D006801:Humans; D007774:Lactation / Q000502:physiology; D008017:Life Expectancy / Q000639:trends; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology
D004967:Estrogens
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