Acute renal failure in severe pancreatitis: A population-based study.
BACKGROUND
Acute pancreatitis (AP) is a common illness with varied mortality and morbidity. Patients with AP complicated with acute renal failure (ARF) have higher mortality than patients with AP alone. Although ARF has been proposed as a leading mortality cause for AP patients admitted to the ICU, few studies have directly analyzed the relationship between AP and ARF.


METHODS
We performed a retrospective study using the population-based database from the Taiwan National Health Insurance Research Database (NHIRD). In the period from 1 January 2005 to 31 December 2005, every patient with AP admitted to the ICU was included and assessed for the presence of ARF and mortality risk.


RESULTS
In year 2005, there were a total of 221,101 admissions to the ICU. There were 1,734 patients with AP, of which 261 (15.05%) patients also had a diagnosis of ARF. Compared to sepsis and other critical illness, patients with AP had a higher risk of having a diagnosis of ARF, and patients with both diagnoses had a higher mortality rate in the same ICU hospitalization.


CONCLUSIONS
AP is associated with a higher risk of ARF, and, when both conditions exist, a higher risk of mortality is present.
National Yang-Ming University School of Medicine, Taiwan, Republic of China.
Hung-Yuan
HY
Lin
Jiun-I
JI
Lai
Yi-Chun
YC
Lai
Po-Chou
PC
Lin
Shih-Chieh
SC
Chang
Gau-Jun
GJ
Tang
D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications*; D012189:Retrospective Studies
Eur J Intern Med. 2004 Aug;15(5):274-280
15450983
Pancreatology. 2003;3(2):144-8
12748423
Am J Public Health. 2005 Mar;95(3):458-65
15727977
Med Clin (Barc). 2000 Dec 2;115(19):721-5
11141437
Dig Dis Sci. 2008 Feb;53(2):297-306
17597411
Arch Surg. 1993 May;128(5):586-90
8489394
Pancreas. 2000 Oct;21(3):266-71
11039471
N Engl J Med. 1994 Apr 28;330(17):1198-210
7811319
Crit Care Med. 1985 Oct;13(10):818-29
3928249
Am Fam Physician. 2007 May 15;75(10):1513-20
17555143
J Crit Care. 2010 Jun;25(2):225-9
19781906
Ren Fail. 1996 Jul;18(4):621-8
8875688
Surg Gynecol Obstet. 1974 Jul;139(1):69-81
4834279