Detection of early colorectal cancer development in the azoxymethane rat carcinogenesis model with Fourier domain low coherence interferometry.
Fourier domain low coherence interferometry (fLCI) is an emerging optical technique used to quantitatively assess cell nuclear morphology in tissue as a means of detecting early cancer development. In this work, we use the azoxymethane rat carcinogenesis model, a well characterized and established model for colon cancer research, to demonstrate the ability of fLCI to distinguish between normal and preneoplastic ex-vivo colon tissue. The results show highly statistically significant differences between the measured cell nuclear diameters of normal and azoxymethane-treated tissues, thus providing strong evidence that fLCI may be a powerful tool for non-invasive, quantitative detection of early changes associated with colorectal cancer development.
Francisco E
FE
Robles
Yizheng
Y
Zhu
Jin
J
Lee
Sheela
S
Sharma
Adam
A
Wax
Opt Lett. 2008 Jun 15;33(12):1285-7
18552933
Opt Lett. 2010 Feb 1;35(3):360-2
20125721
J Biomed Opt. 2002 Jul;7(3):457-63
12175297
Opt Lett. 2007 Feb 15;32(4):385-7
17356661
Opt Lett. 2009 Oct 15;34(20):3196-8
19838271
Nat Med. 2001 Nov;7(11):1245-8
11689891
Opt Express. 2009 Apr 13;17(8):6799-812
19365509
Gastrointest Endosc. 2003 Apr;57(4):441-5
12665750
Gastroenterology. 2008 Oct;135(4):1069-78
18722372
Gastrointest Endosc. 1995 Aug;42(2):114-22
7590045
Opt Lett. 2001 Mar 15;26(6):322-4
18040311
J Biomed Opt. 2009 Nov-Dec;14(6):064030
20059268
Cancer Res. 2003 Apr 15;63(8):1727-30
12702551
N Engl J Med. 2002 Jan 3;346(1):40-4
11778002
Cancer Res. 1988 Nov 1;48(21):6187-92
3167865
Eur J Surg. 2001 Oct;167(10):777-81
11775731
Appl Opt. 1999 Nov 1;38(31):6628-37
18324198
Am J Gastroenterol. 1995 Jan;90(1):24-8
7801943
J Biomed Opt. 2011 Oct;16(10):106002
22029349
Nat Methods. 2007 Sep;4(9):717-9
17694065
J Biomed Opt. 2006 Jul-Aug;11(4):041125
16965153
Environ Mol Mutagen. 2004;44(1):26-35
15199544