Complete resolution of clozapine-induced sialorrhea with low dose trihexyphenidyl.
Clozapine-induced sialorrhea (CIS) is a frequently occurring debilitating adverse effect. Although various treatment options exist, none has been proved to be distinctly superior to others. We report a case of CIS that responded to low dose of trihexyphenidyl (2 mg/day).
Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India. samirpsyche@yahoo.co.in
Samir Kumar
SK
Praharaj
Sujit
S
Sarkhel
Roshan Vitthalrao
RV
Khanande
Vinod Kumar
VK
Sinha
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D012798:Sialorrhea / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome; D014282:Trihexyphenidyl / Q000008:administration & dosage*
D014150:Antipsychotic Agents; D018727:Muscarinic Antagonists; D014282:Trihexyphenidyl; D003024:Clozapine