[Paraoxonase--important enzyme of the lipid metabolism and potential ally in the antiatherosclerotic treatment].
In composed process of atherogenesis take part different classes of lipoproteins. Atherogenic are low density lipoproteins (LDL), especially their modified, like oxidized, particles. Different role have high density lipoproteins (HDL): those molecules could protect arterial wall. This effect depends eg. on the presence paraoxonase 1 (PON 1) in HDL molecules. PON 1 is the enzyme with hydrolase activity. PON 1 protects lipoproteins against oxidative stress and makes possible to metabolize lipid peroxides. Several polymorphisms of the gene PON 1 have been identified. The most important for enzyme activity seem to be two polymorphisms: in the position 55 (L55M) and in the position 192 (R192Q). For instance the genotype PON 1 55 MM is connected with low enzyme serum level. Gene polymorphisms of PON could be one of the possibilities genetic conditioning of atherosclerosis.
Akademia Medyczna we Wrocławiu, Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii. b.sapian@wp.pl
Bozena
B
Sapian-Raczkowska
Maciej
M
Rabczyński
Rajmund
R
Adamiec
D043303:Aryldialkylphosphatase / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism*; D050197:Atherosclerosis / Q000188:drug therapy* / Q000201:enzymology*; D006801:Humans; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D011110:Polymorphism, Genetic
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D043303:Aryldialkylphosphatase