Dissecting teleost B cell differentiation using transcription factors.
B cell developmental pathways in teleost fishes are poorly understood. In the absence of serological reagents, an alternative approach to dissecting teleost B cell development is to use transcription factors that are differentially expressed during B cell development. This review discusses the structure and function of six transcription factors that play essential roles during teleost B cell development: Ikaros, E2A, EBF, Pax5, Blimp1, and XbpI. Research on alternative splicing of both the Ikaros and Pax5 genes in rainbow trout is presented, including their functional significance. An application is discussed that should aid in elucidating teleost B cell development and activation, by using transcription factors as developmental markers in flow cytometric analysis. Possible future studies in teleost B cell development are suggested in the context of gene regulation. Lastly, broader impacts and practical applications are discussed.
The College of William and Mary, Department of Biology, Williamsburg, VA 23187, USA. pxzwol@wm.edu
Patty
P
Zwollo
D017398:Alternative Splicing / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002469:Cell Separation; D005399:Fishes / Q000276:immunology; D005434:Flow Cytometry; D018507:Gene Expression Regulation, Developmental / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics; D014157:Transcription Factors / Q000276:immunology*
D014157:Transcription Factors
Semin Immunol. 2008 Aug;20(4):221-7
18722139
Immunol Res. 2008;42(1-3):106-17
18818886
Mol Cell Biol. 1994 Nov;14(11):7111-23
7935426
Immunity. 1997 Jul;7(1):25-36
9252117
Nat Immunol. 2005 Mar;6(3):295-302
15685175
Immunity. 2007 Jul;27(1):49-63
17658281
Mol Cell Biol. 2007 Jan;27(2):579-94
17101802
Biochem Biophys Res Commun. 2007 Aug 3;359(3):778-83
17560942
J Exp Med. 2004 Oct 18;200(8):967-77
15492122
Cell. 1989 Mar 10;56(5):777-83
2493990
J Immunol. 2006 Aug 15;177(4):2463-76
16888008
Nat Immunol. 2006 Oct;7(10):1116-24
16980980
Nucleic Acids Res. 2000 Dec 15;28(24):4846-55
11121475
Dev Comp Immunol. 2010 Dec;34(12):1291-9
20705088
Cancer Res. 1999 Apr 1;59(7 Suppl):1716s-1724s; discussion 1724s-1725s
10197586
Physiol Genomics. 2005 Apr 14;21(2):144-51
15713784
Dev Comp Immunol. 1985 Summer;9(3):433-44
3899761
Nat Immunol. 2007 May;8(5):463-70
17440452
J Biol Chem. 1997 Apr 11;272(15):10160-8
9092562
Proc Natl Acad Sci U S A. 2005 May 10;102(19):6919-24
15863615
Mol Cell Biol. 1991 Feb;11(2):1156-60
1990271
Development. 1998 Aug;125(16):3063-74
9671580
Bioessays. 2008 Mar;30(3):203-7
18293359
Exp Cell Res. 2009 Apr 15;315(7):1077-84
19073176
Dev Comp Immunol. 2008;32(12):1482-96
18616961
J Exp Med. 1998 Aug 17;188(4):699-713
9705952
J Exp Med. 1996 Feb 1;183(2):393-401
8627152
J Immunol. 2000 Jul 1;165(1):306-12
10861066
Nat Immunol. 2010 Sep;11(9):827-35
20676094
EMBO J. 1996 Oct 1;15(19):5358-69
8895580
Science. 1992 Oct 30;258(5083):808-12
1439790
Gen Comp Endocrinol. 1997 Dec;108(3):483-96
9405124
Immunogenetics. 2005 May;57(3-4):273-82
15900499
Cell. 2001 Dec 28;107(7):881-91
11779464
Annu Rev Immunol. 1997;15:155-76
9143685
Cell. 1994 Oct 7;79(1):143-56
7923373
BMC Genomics. 2010 Apr 30;11:279
20433749
Vet Immunol Immunopathol. 1986 Jun;12(1-4):39-45
3490046
Immunity. 2007 Jul;27(1):8-10
17663980
Nat Rev Immunol. 2001 Dec;1(3):193-9
11905828
Dev Dyn. 2001 Dec;222(4):694-8
11748838
Exp Cell Res. 2007 Jan 15;313(2):331-40
17098231
Curr Opin Immunol. 2007 Apr;19(2):156-62
17291741
Immunol Rev. 1998 Dec;166:177-86
9914912
J Biol Chem. 2001 Nov 9;276(45):42565-74
11535600
J Biol Chem. 2004 Nov 26;279(48):49956-63
15385562
FEBS Lett. 2007 Jul 31;581(19):3652-7
17475256
Vet Immunol Immunopathol. 1997 Sep 19;58(3-4):363-74
9436279
J Immunol. 2005 Jun 1;174(11):6608-16
15905499
EMBO J. 1999 Nov 15;18(22):6307-18
10562543
J Immunol. 2004 Dec 15;173(12):7317-23
15585855
BMC Bioinformatics. 2007 Jun 04;8:180
17547750
Eur J Immunol. 1997 Nov;27(11):3049-58
9394836
Nat Immunol. 2008 Aug;9(8):927-36
18568028
Dev Comp Immunol. 2008;32(10):1105-10
18511119
Nat Immunol. 2008 Feb;9(2):203-15
18176567
Trends Immunol. 2003 Nov;24(11):567-70
14596876
Comp Biochem Physiol Part D Genomics Proteomics. 2006 Mar;1(1):109-14
20483239