[Selective influence of dehydroepiandrosterone-sulphate on anxiety induced by corticotropin-releasing hormone injection].
The objective of this study was to ascertain the effect of dehydroepiandrosterone-sulphate (DHEA-S) on changes of anxiety level, induced by corticotropin-releasing hormone (CRH) injection. Active and passive rats were selected from Wistar rats on the basis of T-maze testing. Active rats were then divided into the groups with high (HA) and low anxiety (LA) level after testing in elevated-plus maze. Intranasal injection of CRH induced increase of anxiety level in the LA rats, while in HA rats it remained unchanged. DHEA-S exerted a moderate anxiolytic effect on the LA rats and sedative effect--on the HA rats. DHEA-S injection had no effect on anxiety level in passive rats that typically demonstrate high level of trait-anxiety and resistance to CRH. These results suggest that DHEA-S effect depends on the individual psycho-emotional status and responsiveness to CRH.
O G
OG
Semenova
V V
VV
Rakitskaia
E A
EA
Vershinina
N É
NÉ
Ordian
V G
VG
Shaliapina
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000009:adverse effects* / Q000494:pharmacology; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D006728:Hormones / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000276:Adjuvants, Immunologic; D006728:Hormones; D003687:Dehydroepiandrosterone; D003346:Corticotropin-Releasing Hormone