Current medical management of peptic ulcer disease.
Peptic ulceration occurs when the digestive action of gastric secretions overcomes gastroduodenal mucosal defences. The therapeutic strategy used to correct this imbalance uses drugs that either reduce gastric secretion or increase mucosal resistance. Traditional therapies of dietary manipulation and antacid administration no longer play major roles in peptic ulcer therapy. Uncomplicated peptic ulcers respond quite well to drug treatment, although recurrences are common and may require long-term maintenance therapy. Drug-induced gastric ulcers have represented a challenging problem, for which effective therapy is now available.
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Scand J Gastroenterol. 1986 May;21(4):385-91
3523739
Gastroenterology. 1989 Feb;96(2 Pt 2 Suppl):626-31
2642448
Am J Med. 1978 Sep;65(3):399-402
82402
Gastroenterology. 1983 Oct;85(4):875-80
6350097
Gastroenterology. 1989 Feb;96(2 Pt 2 Suppl):675-81
2642452
Gastroenterology. 1986 Feb;90(2):478-81
3510148
Gastroenterology. 1989 Jun;96(6):1445-52
2565844
J Clin Gastroenterol. 1989 Feb;11(1):12-6
2646357