The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation.
The identification of several families of innate pattern recognition receptors has greatly enhanced our understanding of the host innate immune response against a variety of pathogens. One such family of innate receptors is the nucleotide-binding domain and leucine rich repeat containing receptors (NLRs). NOD2 has been characterized as a cytosolic sensor of bacteria peptidoglycan (PGN). For almost 10 years, NOD2 was assigned with the function of mediating the RICK- and nuclear factor-κB induced proinflammatory response triggered by PGN. Recent studies have extended the biological activity of NOD2 to include the induction of autophagy and antiviral responses, as well as mediating direct T cell activation. Here, we highlight and discuss these new findings in the context of immune activation and pathogen detection.
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Michael H
MH
Shaw
Nobuhiko
N
Kamada
Neil
N
Warner
Yun-Gi
YG
Kim
Gabriel
G
Nuñez
D056704:Adaptive Immunity; D000818:Animals; D001343:Autophagy; D006801:Humans; D008213:Lymphocyte Activation; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology*
D053473:Nod2 Signaling Adaptor Protein
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