[Effect of benzimidazole derivative with hypoglycemic activity on reproduction processes in females rats].
Toxicological experiments showed that the new benzimidazole derivative with hypoglycemic action--diabenol--influences the sexual activity and processes of female fertilization. The estrous cycle, sexual activity and quality of fertilization were activated at females upon the administration of diabenol in a therapeutic dose of 5 mg/kg. It is established that the drug administration in a toxic dose of 160 mg/kg suppresses the sexual activity and, at the same time, does not affect the estrous cycle and quality of fertilization in females.
A A
AA
Spasov
E A
EA
Kuzubova
L I
LI
Bugaeva
D N
DN
Rebrova
D000818:Animals; D001562:Benzimidazoles / Q000009:adverse effects* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D030762:Estrous Cycle / Q000187:drug effects*; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*
C501282:9-diethylaminoethyl-2,3-dihydroimidazo(1,2alpha)benzimidazole; D001562:Benzimidazoles; D007004:Hypoglycemic Agents