Carbon dioxide insufflation compared with air insufflation in double-balloon enteroscopy: a prospective, randomized, double-blind trial.
BACKGROUND
Few studies have evaluated the degree of pain, the amount of retained gas, and the safety of carbon dioxide (CO(2)) insufflation in patients undergoing double-balloon enteroscopy (DBE).


OBJECTIVE
To clarify the usefulness and safety of CO(2) insufflation during DBE.


METHODS
Single-center, prospective, randomized, double-blind, controlled trial.


METHODS
University hospital.


METHODS
Forty eligible patients with small-bowel disease for whom DBE was indicated were randomized to a CO(2) insufflation (CO(2)) group or an air insufflation (air) group by means of sealed envelopes.


METHODS
DBE with insufflation of CO(2) or air.


METHODS
Efficacy evaluation was based on the degree of pain as assessed by use of a visual analog scale (VAS) and the amount of residual gas retention within the small and large bowels on radiography. The safety of CO(2) insufflation was evaluated by arterial blood gas analysis.


RESULTS
Significantly fewer patients in the CO(2) group had severe pain of ≥ 50 mm on the VAS during DBE than in the air group (P = .02). Significantly less gas was retained in the small bowel just after and at 3 hours after DBE in the CO(2) group than in the air group (P = .003, P = .01, respectively). There was significantly less residual gas retention in the large bowel at 3 hours after DBE in the CO(2) group than in the air group (P = .02). There was no significant difference in pre-DBE and post-DBE partial pressure of oxygen in the blood (PaO(2)) and partial pressure of carbon dioxide in the blood (PaCO(2)) between groups.


CONCLUSIONS
Small sample size.


CONCLUSIONS
CO(2) insufflation is a safe and useful procedure when performed during DBE.
Department of Gastroenterology, Fukuoka University Chikushi Hospital, 1-1-1, Zokumyoin, Chikushino, Japan.
Fumihito
F
Hirai
Takahiro
T
Beppu
Taku
T
Nishimura
Noritaka
N
Takatsu
Shinya
S
Ashizuka
Takehiko
T
Seki
Takashi
T
Hisabe
Takashi
T
Nagahama
Kenshi
K
Yao
Toshiyuki
T
Matsui
Tsuyoshi
T
Beppu
Rikiya
R
Nakashima
Naomi
N
Inada
Eriko
E
Tajiri
Hideko
H
Mitsuru
Hideko
H
Shigematsu
D000328:Adult; D000388:Air; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D058582:Double-Balloon Enteroscopy / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007327:Insufflation / Q000379:methods*; D007410:Intestinal Diseases / Q000097:blood / Q000175:diagnosis*; D007421:Intestine, Small; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D015203:Reproducibility of Results
D002245:Carbon Dioxide; D010100:Oxygen