Synthesis, Characterization, and Biological Evaluation of certain 6-methyl-2(3H)-benzo-1, 3-thiazolyl-1'-ethylidene-2-(o, p- Substituted Acetophenones) Hydrazine Analogs.
In the present study, five new derivatives (GG4 to GG8) of benzothiazoles were synthesized and evaluated against Staphylococcus aureus (MTCC 737), Pseudomonas aeruginosa (MTCC 424), Escherichia coli (MTCC 1687), and yeast-like fungi Candida tropicalis. p-Toluidine on treatment with ammonium thiocynate formed 2-benzothiazolamines (II), which on reaction with hydrazine hydrate formed a hydrazino derivative (III). Compounds GG4 to GG8 were synthesized by reacting the hydrazine derivative with different acetophenones. All the synthesized compounds were identified by IR and (1)H-NMR, and antimicrobial activity was performed on the synthesized compounds. Presence of NO(2), Br, OCH(3), and Cl groups to the substituted benzothiazole enhanced the antibacterial and antifungal activities.
G.H.G Khalsa College of Pharmacy, Gurusar Sadhar - 141 104, Punjab, India.
G
G
Alang
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G
Kaur
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R
Kaur
A
A
Singh
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R
Tiwari
J Pharmacol Exp Ther. 2006 Jan;316(1):189-99
16188953
Bioorg Med Chem Lett. 2008 May 1;18(9):2871-7
18424136
Bioorg Med Chem. 2003 Nov 3;11(22):4769-77
14556792
Farmaco. 2005 Apr;60(4):291-7
15848203
Farmaco. 1998 Jan;53(1):80-4
9543729
Bioorg Med Chem. 2009 Jul 15;17(14):5275-84
19502068
Bioorg Med Chem Lett. 2000 Mar 6;10(5):513-5
10743960
Bioorg Med Chem Lett. 2002 Nov 18;12(22):3275-8
12392731