Mammographic density and its interaction with other breast cancer risk factors in an Asian population.
BACKGROUND
Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear.


METHODS
From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression.


RESULTS
Density was a significant risk factor, adjusting for other factors. Density of 76-100% had an odds ratio of 5.54 (95% CI 2.38-12.90) compared with 0-10%. Density had significant interactions with body mass index and oral contraceptive use (P=0.02).


CONCLUSIONS
Percent density increases breast cancer risk in addition to effects of other risk factors, and modifies the effects of BMI and OCs.
Centre For Molecular Epidemiology, National University of Singapore, Blk MD3, 16 Medical Drive, Singapore 117597, Singapore.
C S
CS
Wong
G H
GH
Lim
F
F
Gao
R W
RW
Jakes
J
J
Offman
K S
KS
Chia
S W
SW
Duffy
D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012307:Risk Factors; D012846:Singapore
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