Primary sebaceous carcinoma of the tongue.
Sebaceous carcinoma is the rarest type of oral malignancies. We report a case of primary sebaceous carcinoma of the tongue. Systemic imaging studies revealed that the patient had a T2N2cM0 (International Union Against Cancer guidelines) primary lingual tumor. Histopathological examination revealed neoplastic sebocytic and basaloid cells, and Sudan III staining and electron microscopy revealed intracytoplasmic lipid droplets. The neoplastic cells stained positive for adipophilin; epithelial membrane antigen; epithelial antigen; and cytokeratins 7, 8, and 15, but negative for cytokeratins 5/6, 18, 19, and 20; the androgen receptor; and carcinoembryonic antigen. Superselective intraarterial chemotherapy was administered via the superficial temporal artery concurrent with daily radiotherapy. Multiple biopsies confirmed a complete response of the primary lesion. The patient then underwent neck dissection followed by pathological examination, which revealed lymph nodes metastases. After postoperative radiotherapy to the neck, distant metastases were identified in the mediastinal lymph nodes and the lung. The patient died 17 months after completing the initial course of chemoradiotherapy. Our case demonstrates that superselective intraarterial chemotherapy combined with concurrent radiotherapy can be effective in treating the primary lesion of patients with a sebaceous carcinoma of the tongue. However, an effective strategy to eradicate metastases has yet to be established.
Department of Pathology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. oshiroh@yokohama-cu.ac.jp
Hisashi
H
Oshiro
Toshinori
T
Iwai
Makoto
M
Hirota
Kenji
K
Mitsudo
Iwai
I
Tohnai
Ryogo
R
Minamimoto
Motoko
M
Omura-Minamisawa
Yoji
Y
Nagashima
Shoji
S
Yamanaka
Takafumi
T
Fukui
Michiyo
M
Kanazawa
Hiromi
H
Sagawa
Kazuhiro
K
Mita
Takashi
T
Nakayama
Yoshiaki
Y
Inayama
D018266:Adenocarcinoma, Sebaceous / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D000368:Aged; D003131:Combined Modality Therapy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D014062:Tongue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
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