A case of splenic low-grade mucinous cystadenocarcinoma resulting in pseudomyxoma peritonei.
Primary splenic mucinous cystadenocarcinoma (MCCa) is extremely rare, and only six cases appear to have been reported previously. We present herein a case of primary splenic MCCa resulting in pseudomyxoma peritonei (PMP). A 66-year-old Japanese woman presented to a hospital with a chief complaint of upper abdominal pain and a 7-year history of splenic cyst. Cyst rupture was noted on computed tomography, and splenectomy was performed. The abdominal cavity was filled with a large amount of gelatinous ascites, with the appearance of PMP. On the cut surface, multiple cysts containing mucinous material were found within and outside the spleen. Microscopically, splenic parenchyma was occupied by large mucinous pools focally lined with mucinous epithelial cells and mesothelial cell-like cells, which were considered benign. Outside the spleen, a low-grade MCCa component was found. No ectopic pancreatic or intestinal tissue was identified. Although most PMP cases are known to be caused by low-grade mucinous appendiceal tumor, the present case represents the first report of a splenic MCCa resulting in PMP.
Department of Surgical Pathology, Kansai Medical University, Hirakata Hospital, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan.
Chisato
C
Ohe
Noriko
N
Sakaida
Yasuaki
Y
Yanagimoto
Hideyoshi
H
Toyokawa
Sohei
S
Satoi
A-Hon
AH
Kwon
Chika
C
Tadokoro
Kosho
K
Takasu
Yoshiko
Y
Uemura
D000368:Aged; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010534:Peritoneal Neoplasms / Q000473:pathology* / Q000601:surgery; D011553:Pseudomyxoma Peritonei / Q000473:pathology* / Q000601:surgery; D013156:Splenectomy / Q000379:methods; D013160:Splenic Neoplasms / Q000473:pathology* / Q000601:surgery
Am J Clin Pathol. 1981 Nov;76(5):666-9
7293981
Histopathology. 1999 Dec;35(6):551-7
10583579
Am J Surg Pathol. 2003 Aug;27(8):1031-51
12883236
Chest. 1977 Dec;72(6):792-4
923321
Dig Dis Sci. 1999 Apr;44(4):768-74
10219836
Surgery. 1976 Nov;80(5):652-4
982285
Am J Surg Pathol. 1992 Sep;16(9):903-8
1415909
Lijec Vjesn. 2000 Nov-Dec;122(11-12):272-5
11291270
Tumori. 1998 Sep-Oct;84(5):606-10
9862526
Nihon Shokakibyo Gakkai Zasshi. 1997 Nov;94(11):757-61
9396331
Am J Surg Pathol. 2005 Mar;29(3):359-67
15725805
Semin Diagn Pathol. 2006 Feb;23(1):20-4
17044192
Int J Clin Oncol. 2006 Oct;11(5):416-9
17058142
J Gastroenterol Hepatol. 2001 Jul;16(7):825-9
11446896
Eur J Gastroenterol Hepatol. 2002 Jul;14(7):793-6
12169992
South Med J. 1989 Aug;82(8):1029-31
2548288
Acta Pathol Jpn. 1981 Nov;31(6):1089-96
7315312
Trop Gastroenterol. 1991 Oct-Dec;12(4):195-8
1814031