Reparative regeneration of rat fetal liver after partial hepatectomy.
A reproducible model of fetal liver regeneration was created. Resection of 20% liver was carried out in rat fetuses on day 17 of prenatal development. The organ weight was restored after 2 days at the expense of an increase in hepatocyte mitotic activity; cell hypertrophy was minor. After recovery, the cell composition of the operated liver did not differ from the control, i.e. the regeneration was organotypical.
Laboratory of Growth and Development, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. elchandrey@yandex.ru
A V
AV
Elchaninov
G B
GB
Bolshakova
D000818:Animals; D002455:Cell Division / Q000502:physiology; D049109:Cell Proliferation; D005333:Fetus / Q000502:physiology* / Q000601:surgery; D006498:Hepatectomy; D022781:Hepatocytes / Q000166:cytology / Q000502:physiology*; D008115:Liver Regeneration / Q000502:physiology*; D008954:Models, Biological; D051381:Rats; D018709:Statistics, Nonparametric