Bacteriophage biocontrol in animals and meat products.
Since their discovery almost a century ago, bacterial viruses (bacteriophages or 'phages') have been used to prevent and treat a multitude of bacterial infections (phage therapy: PT). In addition, they have been the basis for many advances in genetics and biochemistry. Phage therapy was performed on human subjects in the United States, Europe and Asia in the few decades following their discovery. However, Western countries largely abandoned PT in favour of antibiotics in the 1940s. The relatively recent renaissance of PT in the West can be attributed partly to the increasing prevalence of antibiotic resistance in human and animal pathogens. However, the stringent controls on human trials now required in the United States and Europe have led to a greater number of domestic animal and agricultural applications as an alternative to PT in man. This trend is set to continue, at least in the short term, with recent approval from the Food and Drug Administration allowing commercial phage treatments to be used in human food in the USA. Nevertheless, despite these significant milestones and the growing number of successful PT trials, significant obstacles remain to their widespread use in animals, food and ultimately medicine in many parts of the world. This review will provide a brief overview of the history of PT in the West and will summarize some of the key findings of phage biocontrol studies in animals and meat products.
School of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, UK. Robert.Atterbury@bristol.ac.uk
R J
RJ
Atterbury
D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000628:therapy / Q000662:veterinary*; D001435:Bacteriophages / Q000254:growth & development*; D001691:Biological Therapy / Q000379:methods*; D006801:Humans; D008461:Meat Products / Q000382:microbiology*; D010572:Pest Control, Biological / Q000379:methods*
Regul Toxicol Pharmacol. 2005 Dec;43(3):301-12
16188359
Int J Food Microbiol. 2002 Feb 25;73(1):71-81
11883676
Rev Infect Dis. 1988 Jan-Feb;10 Suppl 1:S57-63
3279500
J Clin Invest. 1971 Dec;50(12):2559-68
5129308
Appl Environ Microbiol. 2004 Jun;70(6):3417-24
15184139
Int J Food Microbiol. 1990 May;10(3-4):331-42
2397160
J Exp Med. 1943 Sep 1;78(3):161-8
19871319
Avian Dis. 1998 Jan-Mar;42(1):146-53
9533092
Int J Mol Med. 2006 Feb;17(2):347-55
16391836
Avian Dis. 2008 Mar;52(1):64-7
18459298
Appl Environ Microbiol. 1988 Oct;54(10):2365-70
3060015
J Med Microbiol. 1992 Oct;37(4):258-61
1404324
Semin Hematol. 1993 Oct;30(4 Suppl 4):72-9; discussion 80-1
8303313
Risk Anal. 2007 Aug;27(4):815-30
17958494
Clin Exp Immunol. 1969 Jul;5(1):173-87
5370053
J Bacteriol. 2001 Aug;183(16):4771-8
11466280
Appl Environ Microbiol. 2005 Aug;71(8):4885-7
16085889
Trends Microbiol. 1997 Jul;5(7):268-71
9234508
Surgery. 2005 Jun;137(6):639-46
15933632
Nature. 1989 Aug 10;340(6233):467-8
2755508
J Food Prot. 1986 Feb;49(2):104-109
30959623
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3188-92
8622911
J Food Prot. 2003 Feb;66(2):220-5
12597480
Appl Environ Microbiol. 2003 Oct;69(10):6302-6
14532096
Appl Environ Microbiol. 2009 Jan;75(1):93-100
19011076
J Virol. 2002 Jun;76(11):5557-64
11991984
Riv Biol. 2006 Jan-Apr;99(1):103-29
16791793
Int J Food Microbiol. 2000 Dec 5;62(1-2):1-5
11139009
J Bacteriol. 1973 Dec;116(3):1436-46
4201774
Appl Environ Microbiol. 2006 Jul;72(7):4638-47
16820455
J Gen Microbiol. 1982 Feb;128(2):307-18
7042903
Appl Environ Microbiol. 2008 Oct;74(20):6230-8
18723643
Appl Environ Microbiol. 1995 Apr;61(4):1637-40
7747978
FEMS Microbiol Lett. 2004 Dec 15;241(2):171-7
15598529
Poult Sci. 2002 Oct;81(10):1486-91
12412913
J Food Prot. 1982 Dec;45(14):1318-1325
30913687
J Appl Microbiol. 2006 Jul;101(1):251-9
16834613
J Infect Dis. 2000 Aug;182(2):435-41
10915073
N Engl J Med. 1949 Jul 21;241(3):95
18132673
Arch Virol. 2008;153(3):507-15
18188500
Antimicrob Agents Chemother. 1997 Nov;41(11):2540-3
9371363
Clin Diagn Lab Immunol. 1998 May;5(3):294-8
9605979
Foodborne Pathog Dis. 2008 Apr;5(2):183-91
18407757
Poult Sci. 2005 Jul;84(7):1141-5
16050131
Antimicrob Agents Chemother. 2005 Jul;49(7):2874-8
15980363
Poult Sci. 2006 Aug;85(8):1373-7
16903466
Food Microbiol. 2008 Apr;25(2):400-6
18206783
Annu Rev Microbiol. 1981;35:113-33
7027898
J Theor Biol. 2001 Jan 7;208(1):37-48
11162051
J Bacteriol. 1926 Oct;12(4):245-61
16559213
Acta Vet Scand Suppl. 2000;93:63-8; discussion 68-74
10822859
Clin Microbiol Infect. 2006 Mar;12(3):248-53
16451412
Trends Microbiol. 1998 Aug;6(8):295-7
9746936
Vet Microbiol. 2005 Aug 30;109(3-4):275-83
16024187
Clin Pharmacol Ther. 2000 Sep;68(3):225-30
11014403
Appl Microbiol Biotechnol. 2007 Sep;76(3):513-9
17554535
J Clin Pharm Ther. 2005 Jun;30(3):291-5
15896248
Appl Environ Microbiol. 2006 Aug;72(8):5359-66
16885287
Appl Environ Microbiol. 1985 Jan;49(1):19-23
3156556
Environ Microbiol. 2007 Sep;9(9):2341-53
17686030
Annu Rev Microbiol. 2001;55:437-51
11544363
Appl Environ Microbiol. 2005 Nov;71(11):6554-63
16269681
Avian Pathol. 2005 Jun;34(3):258-63
16191711
PLoS Pathog. 2007 Aug 24;3(8):e119
17722979
BMC Microbiol. 2002 Nov 26;2:35
12453306
J Gen Physiol. 1939 Jan 20;22(3):365-84
19873108
Trends Microbiol. 2001 Mar;9(3):137-44
11303502
Int J Food Microbiol. 2003 May 25;83(1):87-103
12672595
J Gen Appl Microbiol. 2005 Jun;51(3):159-63
16107753
Epidemiol Infect. 2006 Feb;134(1):131-42
16409660
Arch Immunol Ther Exp (Warsz). 1999;47(5):267-74
10604231
Int J Food Microbiol. 2002 Jun 5;76(1-2):151-64
12038572
J Food Prot. 2000 Dec;63(12):1654-9
11131886
Infect Immun. 2002 Nov;70(11):6251-62
12379704
J Gen Physiol. 1940 May 20;23(5):643-60
19873180
Infect Immun. 2002 Jan;70(1):204-10
11748184
J Bacteriol. 2002 Aug;184(16):4529-35
12142423
Appl Environ Microbiol. 1993 Sep;59(9):2914-7
8215364
Avian Dis. 2005 Mar;49(1):118-24
15839424
Int J Food Microbiol. 1997 Mar 3;34(3):197-207
9039566
J Med Microbiol. 2003 Jun;52(Pt 6):483-490
12748267
Appl Environ Microbiol. 2003 Aug;69(8):5032-6
12902308
J Biosci Bioeng. 2005 Sep;100(3):280-7
16243277
J Gen Microbiol. 1983 Aug;129(8):2659-75
6355391
J Antimicrob Chemother. 1986 Oct;18 Suppl C:189-97
3542937
Science. 1973 Aug 10;181(4099):562-4
17777807
J Food Prot. 2002 May;65(5):861-3
12030302
Trends Microbiol. 2002 Nov;10(11):521-9
12419617
J Hyg (Lond). 1936 Jun;36(2):204-35
20475326
Poult Sci. 2005 Apr;84(4):634-43
15844822
J Infect. 1998 Jan;36(1):5-15
9515662
Appl Environ Microbiol. 2007 Jul;73(14):4543-9
17526794
Nat Rev Drug Discov. 2003 Jun;2(6):489-97
12776223
Antimicrob Agents Chemother. 2001 Mar;45(3):649-59
11181338
Res Microbiol. 1991 Jun;142(5):541-9
1947426