[Structural reaction of cardiomyocytes in response to loading on voluntary running wheel].
The aims of this study were to characterize the peculiarities of structural reorganization of right and left ventricular myocardium in response of physical load. Male laboratory white rats (2 month old) were choused in free spinning running wheel (n=5) for 1 month and 2 month (n=5), non-running animals (n=5) serve as control group. Blood acid-base balance and gases were carried out as tissue hypoxia control by Astrup micromethod. Heart weight and ventricular index were measured after rats killing by overdose of intraperitoneally injected pentobarbitone sodium. Cardiomyocytes morphological response were studied by histological and electron microscopical data, also by Selye staining results. Collecting data indicates that heart weight, cardiac muscle fibre cross-sectional area and ventricular index are significantly greater after 1 month physical load modeled by voluntary wheel running in this group. Acid-base balance parameters suggest the low tissues hypoxia and alveolar hypoventilation level that provides a physiologically suitable model to cardiac muscle hypertrophy in rats. In opposite, 2 month duration load acts on the right ventricular cardiomyocytes, including fuchsinophilic dystrophia and homogenization of myofibrils that we can refereed as "physical load induced cardiomyopathy" of right ventricle, so we conclude that this is not physiologically suitable exercise response.
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D000136:Acid-Base Equilibrium; D000818:Animals; D006352:Heart Ventricles / Q000166:cytology*; D008297:Male; D023421:Models, Animal; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000648:ultrastructure; D009929:Organ Size; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D012420:Running / Q000502:physiology; D016276:Ventricular Function / Q000502:physiology*