Nephrotic syndrome developing during induction chemotherapy for childhood acute lymphoblastic leukemia.
This report is the first to document minimal change nephrotic syndrome occurring during induction chemotherapy for childhood acute lymphoblastic leukemia (ALL). This occurrence lends further support to the theory of immune cell dysregulation being central to the pathogenesis of nephrotic syndrome in ALL, rather than alternative postulations that this association is due to an increased risk of malignancy secondary to prior immunosuppressive treatment for nephrotic syndrome.
Division of Nephrology, Department of Pediatrics, British Columbia Children's Hospital, Level 4 Ambulatory Care Building, 4480 Oak Street, Vancouver, BC, V6H3V4, Canada. chanelprestidge@yahoo.com.
Chanel
C
Prestidge
Division of Pediatric Haematology/Oncology/BMT, Department of Pediatrics, BCCH, Vancouver, Canada.
Shahrad Rod
SR
Rassekh
Division of Nephrology, Department of Pediatrics, British Columbia Children's Hospital, Level 4 Ambulatory Care Building, 4480 Oak Street, Vancouver, BC, V6H3V4, Canada.
Douglas G
DG
Matsell
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009402:Nephrosis, Lipoid / Q000209:etiology*; D009404:Nephrotic Syndrome / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents
Postgrad Med. 1984 Nov 1;76(6):147-8, 153-8
6494075
Ann Hematol. 2000 Apr;79(4):222-5
10834511
J Am Soc Nephrol. 2002 May;13(5):1238-1247
11961011
J Pediatr Hematol Oncol. 1998 Sep-Oct;20(5):482-5
9787325
Haematologica. 2007 Jan;92(1):139-40
17229653
Cancer Res. 2005 Jan 1;65(1):264-76
15665303
Eur J Haematol. 2001 Sep;67(3):158-64
11737248
Cytometry. 1993;14(2):196-204
7679964
Child Nephrol Urol. 1990;10(4):231-3
2088598
Am J Med. 1986 Jan;80(1):63-70
3510541
Pediatr Nephrol. 2008 May;23(5):835-9
18188608
Kidney Int. 1991 Nov;40(5):913-6
1762295
Pediatr Nephrol. 1989 Jul;3(3):341-9
2702117
Helv Paediatr Acta. 1976 Jun;31(1):91-5
1065623
Pediatr Nephrol. 2004 Nov;19(11):1290-3
15372224
Ann Intern Med. 1966 Jan;64(1):41-51
5900782
Pediatr Nephrol. 1994 Aug;8(4):527-8
7947054
Nephrol Dial Transplant. 2009 Jan;24(1):149-55
18697798
Eur J Pediatr. 1981 Mar;136(1):105-8
6938373
Pediatr Nephrol. 2000 Aug;14(8-9):872-8
10955948
Isr Med Assoc J. 2002 Nov;4(11):1006-8
12489491
J Am Soc Nephrol. 2001 Aug;12(8):1648-1658
11461937
Am J Kidney Dis. 2007 Nov;50(5):826-9
17954296
Lancet. 1974 Sep 7;2(7880):556-60
4140273
Kidney Int. 1999 Jul;56(1):355-77
10411717