[Influence of new neurohypophyseal hormone analogs on sodium and water reabsorption in rat kidney].
New analogs of some neurohypophyseal hormones (oxypressin, hydrin, glumitocin, vasotocin) have been synthesized. Experiments with injection of these peptides to rats showed that substitution of C-terminal glycinamide on beta-ethanolamine (glycinol) or ethylamine in 1-deamino-arginine vasotocin resulted in loss of natriuretic but not antidiuretic activity. Analogs of oxypressin and hydrin exhibited neither natriuretic activity nor ability to affect water reabsorption. Glumitocin analog induced renal sodium ion excretion and did not influence potassium ion excretion.
A V
AV
Kutina
A S
AS
Marina
K V
KV
Zaĭtseva
I I
II
Eliseev
M I
MI
Titov
Iu V
IuV
Natochin
D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism*; D045283:Natriuretic Agents / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D010909:Pituitary Hormones, Posterior / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D045283:Natriuretic Agents; D010909:Pituitary Hormones, Posterior; D014867:Water