Automated analysis of pharyngeal pressure data obtained with high-resolution manometry.
We present an algorithm developed in MATLAB that can be applied to both normal and disordered swallowing to automatically extract a wide array of measurements from the spatiotemporal plots produced by high-resolution manometry (HRM) of the pharyngeal swallow. The algorithm was developed from data from 12 normal and 3 disordered subjects swallowing 5-ml water boluses. Automated extraction was compared to manual extraction for a subset of seven normal and the three disordered subjects to evaluate algorithm accuracy. Area and line integrals, pressure wave velocity, and pressure gradients during upper esophageal sphincter opening were also measured. Automated extraction showed strong correlations with manual extraction, producing high correlation coefficients in both normal and disordered subjects for maximum velopharyngeal pressure and maximum tongue base pressure. Timing data were also strongly correlated for all variables, including velopharyngeal pressure duration, tongue base pressure duration, and total swallow duration. Preliminary descriptive data on area and line integrals are presented. Our results indicate that the algorithm can effectively extract data automatically from HRM spatiotemporal plots. The efficiency of the algorithm makes it a valuable tool to supplement clinical and research use of HRM.
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Box 7375, Clinical Science Center-H4, 600 Highland Avenue, Madison, WI 53792-7375, USA.
Jason D
JD
Mielens
Matthew R
MR
Hoffman
Michelle R
MR
Ciucci
Jack J
JJ
Jiang
Timothy M
TM
McCulloch
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003679:Deglutition; D003680:Deglutition Disorders / Q000175:diagnosis*; D004935:Esophageal Diseases / Q000175:diagnosis; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D010614:Pharynx / Q000502:physiology*; D011312:Pressure; D058067:Wavelet Analysis; D055815:Young Adult
Otolaryngol Head Neck Surg. 2009 Jul;141(1):119-22
19559970
Ann Otol Rhinol Laryngol. 2000 Jun;109(6):585-9
10855571
Otolaryngol Head Neck Surg. 2010 Feb;142(2):214-7
20115977
Baillieres Clin Gastroenterol. 1991 Jun;5(2):245-67
1912651
Laryngoscope. 1988 Jan;98(1):71-8
3336265
Dysphagia. 1999 Spring;14(2):67-72
10028035
Dysphagia. 2002 Summer;17(3):197-201
12140645
Acta Radiol Diagn (Stockh). 1985 Sep-Oct;26(5):563-8
4072751
Laryngoscope. 2010 Dec;120(12):2367-73
21108425
Arch Phys Med Rehabil. 2001 Dec;82(12):1661-5
11733879
Laryngoscope. 2008 Oct;118(10):1729-32
18641532
Laryngoscope. 1994 May;104(5 Pt 1):571-81
8189989
Dysphagia. 1996 Spring;11(2):83-6
8721063
Folia Phoniatr Logop. 2002 Jul-Aug;54(4):171-6
12169803
Gut. 2008 Mar;57(3):405-23
17895358
Ann Otol Rhinol Laryngol. 2010 Jun;119(6):369-76
20583734
Acta Radiol. 2006 Sep;47(7):628-33
16950694
Arch Phys Med Rehabil. 1989 Oct;70(10):767-71
2802957