New developments in dry powder pulmonary vaccine delivery.
Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing cold-chain storage complications associated with conventional liquid-based vaccines. The particulate nature of dry powder vaccines could also induce a better immune response. This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery.
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Tomás
T
Sou
Els N
EN
Meeusen
Michael
M
de Veer
David A V
DA
Morton
Lisa M
LM
Kaminskas
Michelle P
MP
McIntosh
D000280:Administration, Inhalation; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D058995:Dry Powder Inhalers; D006801:Humans; D007114:Immunization / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage*
D014612:Vaccines