[Combination of antioxidants and a hepatoprotector in the treatment of patients with diabetic distal symmetric polyneuropathy].
The complex open randomized clinical, instrumental and biochemical research with including 89 patients with type 2 diabetes mellitus (DM), complicated with distal symmetric polyneuropathy (DDSP) has been conducted. It is proved that the antioxidant "cocktail" application (Dialipon, Byocerulin, hepatoprotector with the antioxidant action Glutargin) contributes to the improvement of different levels of antioxidant defence, reduces free radical processes intensification, improves hepatocyte state which dysfunction is one of leading links of DDSP pathogenesis. These improves indirectly and directly the peripheral nerves functional state according electroneuromyography results, prevents DDSP progression and development of diabetic foot syndrome. Taking into account negative influence of Dialipon on the clinical parameters of DDSP with parallel intensification of free radical processes at decompensated DM in the early terms of treatment, Dialipon use is recommended after normalization of glycemia. At the same time the positive influence of Byocerulin has been noted regardless the compensation state of diabetes.
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D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002570:Ceruloplasmin / Q000008:administration & dosage / Q000627:therapeutic use*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D004151:Dipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000975:Antioxidants; D004151:Dipeptides; D002570:Ceruloplasmin; C024362:arginine glutamate