Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration.
Both geniposide (Ge) and natural borneol (NB) are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography (HPLC) after intranasal administration of Ge (4 mg/kg) alone and combined with different doses (0.08, 0.8, and 8 mg/kg) of NB. The intravenous administration was given as a reference (4 mg/kg of Ge and 8 mg/kg of NB). Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter (3-5 min vs. 40 min); the peak concentration became higher (1.32-4.25 μg/ml vs. 0.67 μg/ml); and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.
Department of Industrial Pharmacy, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
Yang
Y
Lu
Shou-ying
SY
Du
Xiao-lan
XL
Chen
Qing
Q
Wu
Xiao
X
Song
Bing
B
Xu
Yong-song
YS
Zhai
D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D001682:Biological Availability; D001892:Camphanes / Q000008:administration & dosage*; D004357:Drug Synergism; D032062:Gardenia / Q000737:chemistry; D007275:Injections, Intravenous; D039823:Iridoids / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D001892:Camphanes; D039823:Iridoids; C007835:geniposide; C022871:isoborneol
Cancer Lett. 2010 Jan 1;287(1):75-81
19660857
Brain Res Rev. 2010 Mar;62(2):183-96
19913573
Phytomedicine. 2008 Nov;15(11):993-1001
18339526
J Ethnopharmacol. 2006 Feb 20;103(3):496-500
16169698
Yao Xue Xue Bao. 2006 Feb;41(2):149-55
16671546
Biomed Chromatogr. 2006 Aug;20(8):743-7
16235204
J Oral Pathol Med. 2009 Mar;38(3):276-81
19267840
Food Chem Toxicol. 2008 Aug;46(8):2764-9
18550245
Arch Pharm Res. 2010 May;33(5):691-6
20512466
J Drug Target. 2008 Feb;16(2):178-84
18274938
Int J Pharm. 2007 Jun 7;337(1-2):74-9
17275227
Anal Sci. 2001 Oct;17(10):1237-9
11990605
Int J Pharm. 2007 Jan 10;328(2):161-7
17049426
Planta Med. 2001 Dec;67(9):807-10
11745015
J Control Release. 2003 Feb 21;87(1-3):187-98
12618035
Zhongguo Zhong Yao Za Zhi. 2009 Jul;34(14):1840-4
19894521