Genome-wide functions of PML-RARα in acute promyelocytic leukaemia.
PML-RAR (retinoic acid receptor)α is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RARα target genes, its interplay with RXR and deregulation of epigenetic modifications.
Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, The Netherlands.
S
S
Saeed
C
C
Logie
H G
HG
Stunnenberg
J H A
JH
Martens
D000818:Animals; D044127:Epigenesis, Genetic / Q000502:physiology; D015894:Genome, Human; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008954:Models, Biological; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D015514:Oncogene Proteins, Fusion; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
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