Alcohol consumption and risk of renal cell cancer: the NIH-AARP diet and health study.
BACKGROUND
The effect of moderate to heavy drinking (>15 g per day) on renal cell cancer (RCC) risk is unclear.


METHODS
The relationship between alcohol consumption and RCC was examined in the NIH-AARP Diet and Health Study (n=49 2187, 1814 cases).


RESULTS
Compared with >0 to <5 g per day of alcohol consumption, the multivariate relative risk (95% confidence intervals) for 15 to <30 and 30 g per day was, 0.75 (0.63-0.90) and 0.71 (0.59-0.85), respectively, in men and 0.67 (0.42-1.07) and 0.43 (0.22-0.84), respectively, in women.


CONCLUSIONS
Alcohol consumption was inversely associated with RCC in a dose-response manner. The inverse association may be extended to 30 g per day of alcohol intake.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Bethesda, MD, USA.
J Q
JQ
Lew
W-H
WH
Chow
A R
AR
Hollenbeck
A
A
Schatzkin
Y
Y
Park
D000428:Alcohol Drinking / Q000453:epidemiology*; D002292:Carcinoma, Renal Cell / Q000453:epidemiology*; D004032:Diet; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology*; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
Am J Epidemiol. 2001 Dec 15;154(12):1119-25
11744517
Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1204-11
16775182
Int J Cancer. 2005 Dec 10;117(5):848-53
15957170
Diabetes Care. 1994 Feb;17(2):115-9
7907975
Cancer Detect Prev. 2008;32(1):7-14
18420355
Am J Epidemiol. 2007 Oct 15;166(8):932-40
17656615
Am J Epidemiol. 1991 Apr 15;133(8):810-7
2021148
Nat Rev Urol. 2010 May;7(5):245-57
20448658
Int J Cancer. 2004 Jan 1;108(1):115-21
14618625
Br J Cancer. 2007 Aug 6;97(3):429-33
17653076
Cancer Epidemiol. 2009 Nov;33(5):355-62
19896918
Ann Oncol. 2008 May;19(5):1003-8
18187482
BJU Int. 2010 Jan;105(1):16-20
19583732
J Natl Cancer Inst. 2009 Mar 4;101(5):296-305
19244173
Cancer Causes Control. 2002 Apr;13(3):287-93
12020111
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):170-5
15668492
Am J Epidemiol. 2002 Mar 1;155(5):455-62
11867357
J Natl Cancer Inst. 2007 May 16;99(10):801-10
17505075
Alcohol Res Health. 1999;23(1):55-64
10890798
Am J Epidemiol. 1997 May 15;145(10):909-16
9149662