[Antibiotic resistance of gram-negative Bacillis isolated from children with bronchopneumonia].
OBJECTIVE
To study the distribution and antibiotic resistance of gram-negative pathogens isolated from children with bronchopneumonia.


METHODS
The distribution and the results of susceptibility tests of 272 strains of gram-negative Bacillis isolated from children with bronchopneumonia during 2009 were analyzed.


RESULTS
Among the isolates, the common pathogens were Klebsiella pneumoniae and Escherichia coli. The extended-spectrum β-lactamase (ESBLs) production rate was 52.9%. Compared with the non-ESBLs producing strains, ESBLs-producing strains had a significantly higher drug resistance rate to many antibiotics except amikacin and meropenem (P<0.05). The lowest resistance to ESBLs producing gram negative strains was found for meropenem (0.7%), followed by imipenem, amikacin and cefoperazone/sulbactam.


CONCLUSIONS
More attentions should be paid to the high rate of drug-resistance of ESBLs producing strains in children. Antimicrobial therapy should be based on the results of drug resistance surveillance.
Department of Clinical Pharmacy, Hunan Provincial People's Hospital, Changsha 410002, China.
Hong-Yan
HY
Wei
Bo-Yu
BY
Tan
Li-Jun
LJ
Yang
Nan
N
Deng
D001996:Bronchopneumonia / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male