Triterpenes and steroids from the roots of Scorzonera austriaca.
A new D:B-friedoolean-type triterpene, 3β-acetoxyglutin-5(10)-en-6-oxo (1), together with seventeen known compounds (2-18) was isolated from the roots of Scorzonera austriaca. Their structures were elucidated mainly by NMR and HR-ESI-MS, as well as on comparison with the reported data. Cytotoxicities of compounds 2, 4, 6, 10-14 and 16 against selected cancer cells of human promyelocytic leukemia (HL-60) and human hepatoma (BEL-7404) were measured in vitro.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, PR China.
Quan-Xiang
QX
Wu
Yi-Bin
YB
Su
Ying
Y
Zhu
D006528:Carcinoma, Hepatocellular; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D018517:Plant Roots; D031186:Scorzonera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use
C560729:3-beta-acetoxyglutin-5(10)-en-6-oxo; D010936:Plant Extracts; D014315:Triterpenes