Genesis and "suicide" of eicosanoid biosynthetic enzymes.
Biologically active eicosanoids are substances that initiate, aggravate, or sustain thrombosis and inflammation. Prominent in this regard are thromboxane A(2), a potent coronary vasoconstrictor and platelet-aggregating factor and leukotriene B(4), a potent leukocyte chemotactic agent. Pharmacologic restraint of their formation may be beneficial. Recent research on the natural regulation of their formation recognizes the importance of two processes: the genesis of enzymes and proteins that amplify eicosanoid formation and the "suicide" inactivation that accompanies this formation. The balance of genesis-"suicide" of eicosanoid biosynthetic enzymes offers a new way to raise questions about the role of eicosanoids in cardiac disorders.
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
F A
FA
Fitzpatrick