Generalised muscle weakness in young adults with congenital heart disease.
BACKGROUND
In patients with heart failure from acquired cardiomyopathy, respiratory and skeletal muscle weakness is common and is an independent predictor for adverse events. Despite a different underlying pathology, many young adults with congenital heart disease (CHD) develop a syndrome comparable to heart failure from acquired cardiomyopathy and may be at risk for a similar skeletal muscle weakness.


OBJECTIVE
To assess respiratory and skeletal muscle strength in adults with complex CHD.


METHODS
Respiratory and skeletal muscle function was assessed in 51 adults; 41 with complex CHD (16 tetralogy of Fallot, 11 univentricular anatomy with Fontan operation and 14 with subaortic right ventricles) and 10 controls. Maximal inspiratory (MIPs) and expiratory (MEPs) pressures, handgrip strength, lung volumes and aerobic capacity (peak VO₂) were measured. Results In patients with CHD (age 34 ± 13 years), average% predicted MIPs, MEPs and handgrip strength were lower than in controls (77 ± 27% vs 106 ± 28%, 85 ± 32% vs 116 ± 41% and 72 ± 15% vs 93 ± 14%, respectively, p ≤ 0.01). There was no significant difference in muscle weakness between CHD subgroups. In 39% of patients with CHD, the handgrip strength, and in 22%, respiratory muscle strength was <70% predicted. These patients had a significantly lower peak VO₂ (50 ± 12% vs 64 ± 14% predicted, p=0.008).


CONCLUSIONS
Respiratory and skeletal muscle weakness is common in young adults with complex CHD and similar to that found in older adults with advanced heart failure from acquired heart disease.
Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Division of Cardiology, University of Toronto, Toronto, Canada. matthias.greutmann@usz.ch
Matthias
M
Greutmann
Thao Lan
TL
Le
Daniel
D
Tobler
Patric
P
Biaggi
Erwin N
EN
Oechslin
Candice K
CK
Silversides
John T
JT
Granton
D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005080:Exercise Test; D005260:Female; D018737:Hand Strength; D006330:Heart Defects, Congenital / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D018908:Muscle Weakness / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009864:Ontario; D011312:Pressure; D015656:Respiratory Mechanics; D012132:Respiratory Muscles / Q000503:physiopathology; D013147:Spirometry; D055815:Young Adult