[Inhibitory effect of TBN on platelet aggregation in rabbit].
OBJECTIVE
To investigate the inhibitory effect of TBN on rabbit platelet aggregation in vitro and in vivo, and compare with tetramethylpyrazine (TMP).


METHODS
To seek out the maximum of platelet aggregation (expressed in percentage) within 5 minutes which was induced by ADP, PAF and AA according to the Born turbidimetric method with a Platelet-Aggregometer.


RESULTS
TBN significantly inhibited platelet aggregation induced by ADP, PAF and AA both in vitro and in vivo. TBN was more active than TMP.


CONCLUSIONS
TBN has significant activity inhibiting platelet aggregation induced by ADP, PAF and AA in vitro and in vivo.
Institute of New Drug Research, Jinan University, Guangzhou 510632, China. xucling19820813@126.com
Chang-Lin
CL
Xu
Lu-Chen
LC
Shan
Ye-Wei
YW
Sun
Yu-Qiang
YQ
Wang
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D009391:Nephelometry and Turbidimetry; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits
D001095:Arachidonic Acids; D004365:Drugs, Chinese Herbal; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D000244:Adenosine Diphosphate; C017953:tetramethylpyrazine