Acute superficial sensory neuropathy with generalized anhidrosis, anosmia, and ageusia.
We report a 53-year-old woman with an unusual presentation characterized by acute onset of generalized sensory symptoms associated with anhidrosis, anosmia, ageusia, and elevated titers of anti-GalNAc-GD1a antibodies. After intravenous immunoglobulin therapy, a remarkable improvement in the pain and temperature sensation was noted in her face, trunk, and extremities. The impaired pain and temperature sensation remained distributed along cranial and spinal dermatomes in a non-length-dependent manner, suggesting that the ganglionopathy affected small neurons.
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Yu
Y
Miyazaki
Haruki
H
Koike
Mizuki
M
Ito
Naoki
N
Atsuta
Hirohisa
H
Watanabe
Masahisa
M
Katsuno
Susumu
S
Kusunoki
Gen
G
Sobue
D000370:Ageusia / Q000150:complications*; D005260:Female; D006801:Humans; D007007:Hypohidrosis / Q000150:complications*; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000648:ultrastructure; D000857:Olfaction Disorders / Q000150:complications*; D012678:Sensation Disorders / Q000209:etiology* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology / Q000648:ultrastructure; D013697:Thermosensing / Q000502:physiology