Coexistence of narcolepsy and Alzheimer's disease.
A recent publication suggested that hypocretin (Hcrt, orexin) may mediate the neuropathological process leading to Alzheimer's disease (AD) and that antagonism of hypocretin receptors decreases this process. Narcoleptics have an approximately 90% loss of Hcrt neurons and commensurate reductions in the levels of Hcrt in their cerebrospinal fluid beginning at disease onset, usually before the age of 30. If Hcrt mediates the disease process, narcoleptics should be protected against AD. We examined the postmortem neuropathology and clinical records of 12 sequentially encountered cases of human narcolepsy. We found that AD was present in 4 of these narcoleptics, a prevalence that is similar to that of the general population.
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
T E
TE
Scammell
J K
JK
Matheson
M
M
Honda
T C
TC
Thannickal
J M
JM
Siegel
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009290:Narcolepsy / Q000150:complications* / Q000175:diagnosis*
Neurology. 2009 Aug 18;73(7):511-7
19687452
Neurology. 2005 Oct 25;65(8):1184-8
16247044
Nat Med. 2000 Sep;6(9):991-7
10973318
Neuron. 2000 Sep;27(3):469-74
11055430
Science. 2009 Nov 13;326(5955):1005-7
19779148
Arch Neurol. 2003 Aug;60(8):1119-22
12925369
Neurology. 2005 Oct 25;65(8):1189-92
16135770
JAMA. 1989 Nov 10;262(18):2551-6
2810583
Brain. 2007 Jun;130(Pt 6):1586-95
17491094