Autophagy in immunity and inflammation.
Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy - the 'autophagy proteins' - orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9113, USA. beth.levine@utsouthwestern.edu
Beth
B
Levine
Noboru
N
Mizushima
Herbert W
HW
Virgin
D000818:Animals; D001343:Autophagy / Q000276:immunology* / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D007109:Immunity / Q000276:immunology* / Q000502:physiology; D007113:Immunity, Innate / Q000276:immunology / Q000502:physiology; D007239:Infections / Q000276:immunology / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D010588:Phagosomes / Q000276:immunology / Q000382:microbiology / Q000469:parasitology / Q000821:virology
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