Intracellular organelle-targeted non-viral gene delivery systems.
Gene therapy is a rapidly growing approach for the treatment of various diseases. To achieve successful gene therapy, a gene delivery system is necessary to overcome several barriers in the extracellular and intracellular spaces. Polymers, peptides, liposomes and nanoparticles developed as gene carriers have achieved efficient cellular uptake of genes. Among these carriers, cationic polymers and peptides have been further developed as intracellular organelle-targeted delivery systems. The cytoplasm, nucleus and mitochondria have been considered primary targets for gene delivery using targeting moieties or environment-responsive materials. In this review, we explore recently developed non-viral gene carriers based on reducible systems specialized to target the cytoplasm, nucleus and mitochondria.
Department of Bioengineering, Institute for Bioengineering and Biopharmaceutical Research, and Institute of Aging Society, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea.
Young-Wook
YW
Won
Kwang Suk
KS
Lim
Yong-Hee
YH
Kim
D000166:Acridines / Q000008:administration & dosage; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D018014:Gene Transfer Techniques; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D019913:Nuclear Localization Signals; D015388:Organelles / Q000378:metabolism*; D011073:Polyamines / Q000008:administration & dosage; D011094:Polyethyleneimine / Q000008:administration & dosage
D000166:Acridines; D019913:Nuclear Localization Signals; C531249:Poly(amidoamine); D011073:Polyamines; D011094:Polyethyleneimine