[The epigenetic mechanism of the effect of mildly deleterious mutations on the viability of the progeny and their correction in meiosis].
Data supporting the hypothesis about the epigenetic nature of deleterious mutations leading to the death of a part of the progeny are presented. It is assumed that during the life cycle "mutant" variants of formation of structural-functional loop domains occur in chromosomes that normally are corrected during meiosis. An abnormal loop changes the activity of many tens of genes, both increasing (+) and decresing (-) it, which affects the viability of homozygotes and to a lesser extent the viability of heterozygotes. Hybrids with chromosomes containing independently accumulated deleterious mutations partly restore their viability due to the complementary interactions of + and - genes.
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Chubykin
D000818:Animals; D059006:Chromosomes, Insect / Q000235:genetics*; D004331:Drosophila melanogaster; D044127:Epigenesis, Genetic; D006720:Homozygote; D008540:Meiosis / Q000235:genetics*; D009154:Mutation