Steroids - plenty of benefits, but not without risk.
Thomas D. Myles, MD, is from the Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Women's Health, Saint Louis University, Saint Louis, Missouri; e-mail: mylest@slu.edu.
Thomas D
TD
Myles
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000818:Animals; D001623:Betamethasone / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003907:Dexamethasone / Q000627:therapeutic use; D016883:Diabetic Ketoacidosis / Q000139:chemically induced; D020345:Enterocolitis, Necrotizing / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D007008:Hypokalemia / Q000139:chemically induced; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology; D008278:Magnesium Sulfate / Q000627:therapeutic use; D011247:Pregnancy; D011654:Pulmonary Edema / Q000139:chemically induced; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000517:prevention & control; D012306:Risk; D012756:Sheep; D015145:Tocolysis / Q000009:adverse effects
D000318:Adrenergic beta-Agonists; D005938:Glucocorticoids; D008278:Magnesium Sulfate; D003907:Dexamethasone; D001623:Betamethasone
Liggins GC. Premature delivery of fetal lambs infused with glucocorticoids. J Endocrinol 1969;45:515–23.
Bonanno C, Fuchs K, Wapner RJ. Single versus repeat courses of antenatal steroids to improve neonatal outcomes: risks and benefits. Obstet Gynecol Surv 2007;62:261–71.
Crowley PA. Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. Am J Obstet Gynecol 1995;173:322–35.
Thorp JA, Jones AM, Hunt C, Clark R. The effect of multidose antenatal betamethasone on maternal and infant outcomes. Am J Obstet Gynecol 2001;185:1276–7.
Foglia LM, Deering SH, Lim E, Landy H. Maternal glucose levels after dexamethasone for fetal lung development in twin vs singleton pregnancies. Am J Obstet Gynecol 2008;199:380.e1–4.
Gurbuz A, Karateke A, Ozturk G, Kabaca C. Is 1-hour glucose screening test reliable after a short-term administration of antenatal betamethasone? Am J Perinatol 2004;21:415–20.
Holness MJ, Sugden MC. Dexamethasone during late gestation exacerbates peripheral insulin resistance and selectively targets glucose-sensitive functions in beta cell and liver. Endocrinology 2001;142:3742–8.
Bernstein IM, Catalano PM. Ketoacidosis in pregnancy associated with the parenteral administration of terbutaline and betamethasone. A case report. J Reprod Med 1990;35:818–20.
Mathiesen ER, Christensen AB, Hellmuth E, Hornnes P, Stage E, Damm P. Insulin dose during glucocorticoid treatment for fetal lung maturation in diabetic pregnancy: test of an algorithm [correction of analgoritm]. Acta Obstet Gynecol Scand 2002;81:835–9.
Chua S, Razvi K, Wong MT, Tay R, Arulkumaran S. Is there a need to treat hypokalaemia associated with intravenous salbutamol infusion. J Obstet Gynaecol Res 1997;23:381–7.
Damallie KK, Drake JG, Block WA. Hypokalemic periodic paralysis in pregnancy after 1-hour glucose screen. Obstet Gynecol 2000;95:1037.
Appel CC, Myles TD. Caffeine-induced hypokalemic paralysis in pregnancy. Obstet Gynecol 2001;97:805–7.
Teagarden CM, Picardo CW. Betamethasone-induced hypokalemic periodic paralysis in pregnancy. Obstet Gynecol 2011; 117:433–5.