Skin tissue engineering--in vivo and in vitro applications.
Significant progress has been made over the years in the development of in vitro-engineered substitutes that mimic human skin, either to be used as grafts for the replacement of lost skin or for the establishment of human-based in vitro skin models. This review summarizes these advances in in vivo and in vitro applications of tissue-engineered skin. We further highlight novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development and screening.
Department of Cell and Tissue Engineering, Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, Stuttgart, Germany. katja.schenke-layland@igb.fraunhofer.de
Florian
F
Groeber
Monika
M
Holeiter
Martina
M
Hampel
Svenja
S
Hinderer
Katja
K
Schenke-Layland
D000818:Animals; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D012871:Skin Diseases / Q000473:pathology / Q000601:surgery; D016038:Skin Transplantation / Q000379:methods*; D017768:Skin, Artificial; D023822:Tissue Engineering / Q000379:methods*