Obesity augmented breast cancer risk: a potential risk factor for Indian women.
BACKGROUND
Obesity is caused by disturbances of energy balance, which is homeostasized by the physiological processes. The study aims to determine the possible impact of rising prevalence of obesity and its effect in the development of breast carcinoma (BC) in Indian population.


METHODS
This study is carried out on patients (N = 358) who were diagnosed with BC and breast diseases (BD) by calculating their BMI admitted during the period of 2005 to 2009. NIH criteria were used to categorize the patients. Pathological factors of BC patient were then compared among groups.


RESULTS
These results were indicative of significant positive association between BC risks with peri/post menopausal status, residence, diet nature, and tobacco uses. Metastases were identified more commonly with increasing weight. It was found to be independently associated with obesity I (OR = 3.103, 95% CI = 1.633-5.895) and obesity II (OR = 6.803, 95% CI = 2.415-19.162). Disease stage and cancer related mortality were significantly associated with increased BMI.


CONCLUSIONS
The higher prevalence of severe obesity among Indian population was associated with BC. The only alteration apart from early diagnosis is opting for a more natural lifestyle that will affect energy equilibrium and prove to be a viable option for prevention in carcinoma of breast for better survival.
Department of Biochemistry, Faculty of Science, Banaras Hindu University, Varanasi, India.
Alok K
AK
Singh
Anjita
A
Pandey
Mallika
M
Tewari
Daliparthy D
DD
Pratyush
Hemant K
HK
Singh
Hausila P
HP
Pandey
Hari S
HS
Shukla
D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000150:complications* / Q000208:ethnology; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index