Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.
This study was undertaken to know whether cognition deficits produced by chronic mild stress (CMS) were associated with pathological markers of Alzheimer's disease (AD). The results show that the impairment in the Morris water maze test induced by CMS correlated with an increase in CDK5-dependent phospho-tau levels and with an increase in APP processing. Mice exposed to CMS may then constitute a non-transgenic model for sporadic forms of AD.
Division of Neurosciences, CIMA, University of Navarra, Avenida Pio XII 55, Pamplona, Spain. mcuadrado@unav.es
Mar
M
Cuadrado-Tejedor
Ana
A
Ricobaraza
Joaquín
J
Del Río
Diana
D
Frechilla
Rafael
R
Franco
Alberto
A
Pérez-Mediavilla
Ana
A
Garcia-Osta
D051722:ADAM Proteins / Q000378:metabolism; D000072197:ADAM10 Protein; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism; D001362:Avoidance Learning / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology*; D051360:Cyclin-Dependent Kinase 5 / Q000378:metabolism*; D004268:DNA-Binding Proteins; D004195:Disease Models, Animal; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D018782:Maze Learning / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D051839:NFI Transcription Factors / Q000378:metabolism; D010766:Phosphorylation / Q000502:physiology; D063146:Polycomb-Group Proteins; D011930:Reaction Time / Q000502:physiology; D012694:Serine / Q000378:metabolism; D013315:Stress, Psychological / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism*
D016564:Amyloid beta-Protein Precursor; C077305:CTF-1 transcription factor; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D051839:NFI Transcription Factors; C533390:Phf1 protein, mouse; D063146:Polycomb-Group Proteins; D014157:Transcription Factors; D016875:tau Proteins; D012694:Serine; D051360:Cyclin-Dependent Kinase 5; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse; D051722:ADAM Proteins; D000072197:ADAM10 Protein; C491234:Adam10 protein, mouse