Endurance factors improve hippocampal neurogenesis and spatial memory in mice.
Physical activity improves learning and hippocampal neurogenesis. It is unknown whether compounds that increase endurance in muscle also enhance cognition. We investigated the effects of endurance factors, peroxisome proliferator-activated receptor δ agonist GW501516 and AICAR, activator of AMP-activated protein kinase on memory and neurogenesis. Mice were injected with GW for 7 d or AICAR for 7 or 14 d. Two weeks thereafter mice were tested in the Morris water maze. AICAR (7 d) and GW improved spatial memory. Moreover, AICAR significantly, and GW modestly, elevated dentate gyrus neurogenesis. Thus, pharmacological activation of skeletal muscle may mediate cognitive effects.
Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging/NIH, Baltimore, MD 21224, USA.
Tali
T
Kobilo
Chunyan
C
Yuan
Henriette
H
van Praag
D000263:Adenylate Kinase / Q000378:metabolism; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007150:Immunohistochemistry; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D055495:Neurogenesis / Q000187:drug effects* / Q000502:physiology; D047494:PPAR delta / Q000819:agonists; D010805:Physical Conditioning, Animal / Q000502:physiology; D012265:Ribonucleotides / Q000494:pharmacology*; D013037:Spatial Behavior / Q000187:drug effects / Q000502:physiology; D013844:Thiazoles / Q000494:pharmacology*
C425931:GW 501516; D007004:Hypoglycemic Agents; D047494:PPAR delta; D012265:Ribonucleotides; D013844:Thiazoles; D000620:Aminoimidazole Carboxamide; D000263:Adenylate Kinase; C031143:AICA ribonucleotide
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