Clinical evidence to demonstrate that simultaneous growth of epithelial and fibroblast cells is essential for deep wound healing.
OBJECTIVE
The aim of this study was to evaluate the chronic wound healing properties of tannin rich plant extracts.


METHODS
The cell growth stimulating potential of 128 procyanidin rich plant extracts was evaluated in in vitro cell culture models. For clinical trial, a 3% solution of two plant extracts having synergistic effect on cell growth was prepared in glycerol and honey. Placebo test product contained only glycerol and honey. 93 adult patients with one or more lower extremity deep wounds were divided at randomly in two groups. 41 patients in the placebo (AS-22) and 52 in the active treatment (AS-21) groups having respectively 49 and 69 wounds of a mean surface area of 56.70 and 52.03 cm(2), and volume of 57.22 and 52.15 cm(3), were treated by applying the test products topically for a period of 6-weeks.


RESULTS
A statistically significant difference was observed between the placebo and the AS-21 treated groups with respect to reduction in the wound surface area (33.37 vs 97.87%) and wound volume (29.45 vs 94.17%) after 6-weeks of treatment. Mean wound humidity and pain scores were also reduced.


CONCLUSIONS
Tannin rich plant extracts are highly interesting for the treatment of chronic wounds.
Naturveda, VITROBIO Research Institute, ZAC de Lavaur, 63500 Issoire, France. naturveda@wanadoo.fr
Ravi
R
Shrivastava
D031982:Alchemilla / Q000737:chemistry; D000818:Animals; D031601:Azadirachta / Q000737:chemistry; D028241:Camellia sinensis / Q000737:chemistry; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects*; D006801:Humans; D031298:Mimosa / Q000737:chemistry; D005894:Panax / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D029796:Vaccinium / Q000737:chemistry; D027843:Vitis / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*
D010936:Plant Extracts