Risk factors for hilar cholangiocarcinoma: a case-control study in China.
OBJECTIVE
To study the association between hilar cholangiocarcinoma (HC) and pre-existing medical conditions.


METHODS
Three hundred and thirteen HC patients admitted to the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) in 2000-2005 and 608 healthy controls were enrolled in this study. Association between HC and pre-existing medical conditions was studied with their adjusted odds ratio (OR) calculated by logistic regression analysis.


RESULTS
The prevalence of choledocholithiasis (adjusted OR = 2.704, P = 0.039), hepatolithiasis (adjusted OR = 3.278, P = 0.018), cholecystolithiasis (adjusted OR = 4.499, P < 0.0001), cholecystectomy (adjusted OR = 7.012, P = 0.004), biliary ascariasis (adjusted OR = 7.188, P = 0.001), liver fluke (adjusted OR = 10.088, P = 0.042) and liver schistosomiasis (adjusted OR = 9.913, P = 0.001) was higher in HC patients than in healthy controls.


CONCLUSIONS
Biliary tract stone disease (choledocholithiasis, hepatolithiasis, cholecystolithiasis) and parasitic liver disease (biliary ascariasis, liver fluke, liver schistosomiasis) are the risk factors for HC in Chinese population.
Department of Biliary Surgery II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China. caiwenke002@126.com
Wen-Ke
WK
Cai
Hui
H
Sima
Ben-Dong
BD
Chen
Guang-Shun
GS
Yang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001196:Ascariasis / Q000453:epidemiology; D001650:Bile Duct Neoplasms / Q000175:diagnosis*; D016022:Case-Control Studies; D002681:China; D018281:Cholangiocarcinoma / Q000175:diagnosis*; D002763:Cholecystectomy / Q000379:methods; D041761:Cholecystolithiasis / Q000453:epidemiology; D042883:Choledocholithiasis / Q000453:epidemiology; D005210:Fasciola hepatica; D005260:Female; D006801:Humans; D020347:Lithiasis / Q000453:epidemiology; D008107:Liver Diseases / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012044:Regression Analysis; D012307:Risk Factors; D012552:Schistosomiasis / Q000453:epidemiology
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