Behavioral effects of peripheral corticotropin-releasing factor during maternal separation may be mediated by proinflammatory activity.
When guinea pig pups are separated from their mothers in a novel environment, an initial period of active behavior (vocalizing, locomotor activity) wanes after an hour or so and is replaced by a second, passive stage characterized by a crouched stance, closed eyes, and extensive piloerection. If pups are given a peripheral injection of 7-14μg of corticotropin-releasing factor (CRF) prior to testing, the passive behaviors occur immediately upon separation. We found that intracerebroventricular infusion of 1-10μg of CRF did not increase passive behavior relative to vehicle infusion, but that peripheral injection of the anti-inflammatory cytokine, interleukin-10, attenuated the passive behavior induced by peripheral CRF injection. These results together with previous findings suggest that peripheral CRF administration affects behavior of separated guinea pig pups through a mechanism that involves peripheral proinflammatory activity. The possible role of endogenous peripheral CRF in the behavioral response of untreated pups during maternal separation is considered.
Department of Psychology, Wright State University, Dayton, OH 45435, United States. michael.hennessy@wright.edu
Michael B
MB
Hennessy
Christopher
C
Fitch
Sarah
S
Jacobs
Terrence
T
Deak
Patricia A
PA
Schiml
D000223:Adaptation, Psychological / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D018836:Inflammation Mediators / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D016753:Interleukin-10 / Q000008:administration & dosage / Q000494:pharmacology; D008426:Maternal Deprivation; D012934:Social Isolation / Q000523:psychology
D018836:Inflammation Mediators; D016753:Interleukin-10; D003346:Corticotropin-Releasing Hormone
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