Is the rapid whole blood test useful for diagnosis and monitoring celiac disease in children?
OBJECTIVE
To evaluate a new whole blood rapid test for the detection of IgA anti-transglutaminase (ATG) for diagnosis and diet survey of celiac disease (CD).


METHODS
57 children, 20 of them were CD patients on a gluten-free diet and 37 were under suspicion of CD were enrolled. IgAATG was detected by the conventional ELISA test and the new rapid whole blood test.


RESULTS
Concordance between the 2 tests was 96.4%. All patients positive with ELISA were also positive by the rapid test. Only 2 patients were slightly positive by the rapid test and negative by ELISA.


CONCLUSIONS
Whole blood rapid test seems to be as performant as ELISA test for IgAATG detection.
Immunology Department, La Rabta Hospital, Tunis, Tunisia.
Lilia
L
Laadhar
Maryam
M
Kallel-Sellami
Mondher
M
Zitouni
Ahmed
A
Mehrezi
Sondes
S
Makni
Mongi
M
Ben Hariz
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007223:Infant; D008297:Male; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012698:Serologic Tests
D001323:Autoantibodies; D007070:Immunoglobulin A