Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro.
Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293), four cancer cell lines, gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) with a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity toward a variety of cancer cell lines. In contrast only some extracts from Coprinus comatus, Cordyceps hawkesii, Hypholoma fasciculare, Lepista nuda, Leratiomyces ceres and Ophiocordyceps robertsii displayed significant cytotoxic activity, which was usually selective for only one or two cancer cell lines tested. The least cytotoxic species evaluated in this study were Agaricus bitorquis, Coprinopsis atrametaria, Psathyrella asperospora, Russula clelandii, Tricholoma sp. AU2 and Xerula mundroola.
School of Pharmacy, Griffith University, Gold Coast campus, Queensland 4222, Australia.
Karren D
KD
Beattie
Rahel
R
Ulrich
I Darren
ID
Grice
Shaikh J
SJ
Uddin
Tony B
TB
Blake
Kyle A
KA
Wood
Jules
J
Steele
Fontaine
F
Iu
Tom W
TW
May
Evelin
E
Tiralongo
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001315:Australia; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D004847:Epithelial Cells / Q000187:drug effects*; D005658:Fungi / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells
D000970:Antineoplastic Agents