Hemostasis and platelet dysfunction in asphyxiated neonates.
Hemostasis is the balance between bleeding and clotting and includes coagulation and fibrinolysis with platelet interactions. Despite developmental hemostasis that describes the major differences between neonates and older children and adults, neonates do not have increased bleeding or clotting unless clinical situations disturb the "balance." Perinatal asphyxia alters the balance of hemostasis, resulting in abnormalities that may result in bleeding and thrombosis. The following discussion will describe normal hemostasis, laboratory measures of hemostasis, developmental hemostasis, and the effects of asphyxia on hemostasis.
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Mary E
ME
Bauman
Po-Yin
PY
Cheung
M Patricia
MP
Massicotte
D001238:Asphyxia Neonatorum / Q000097:blood / Q000150:complications*; D001777:Blood Coagulation; D001791:Blood Platelet Disorders / Q000097:blood / Q000209:etiology*; D006470:Hemorrhage / Q000097:blood / Q000209:etiology; D006487:Hemostasis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D013927:Thrombosis / Q000097:blood / Q000209:etiology