Nickel-catalyzed reductive cleavage of aryl-oxygen bonds in alkoxy- and pivaloxyarenes using hydrosilanes as a mild reducing agent.
A nickel-catalyzed reductive deoxygenation of aryl alkyl ethers and aryl pivalates has been developed. Hydrosilanes serve as a mild reducing agent. The present protocol allows the use of a pivalate group as a robust and traceless steering group in arene functionalization reactions.
Frontier Research Base for Global Young Researchers, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. tobisu@chem.eng.osaka-u.ac.jp
Mamoru
M
Tobisu
Ken
K
Yamakawa
Toshiaki
T
Shimasaki
Naoto
N
Chatani
D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010421:Pentanoic Acids / Q000737:chemistry; D019163:Reducing Agents / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D006841:Hydrocarbons, Aromatic; D010421:Pentanoic Acids; D019163:Reducing Agents; D012821:Silanes; D009532:Nickel; C005566:pivalic acid; D010100:Oxygen