Body mass index and adult weight gain among reproductive age women with migraine.
OBJECTIVE
To evaluate the cross-sectional relationship between migraine and pregravid obesity; and to assess the risk of adult weight gain among women with history of a pediatric diagnosis of migraine.


BACKGROUND
Obesity, comorbid with pain disorders including migraine, shares common pathophysiological characteristics including systemic inflammation, and derangements in adipose-tissue derived cytokines. Despite biochemical and epidemiological commonalities, obesity-migraine associations have been inconsistently observed.


METHODS
A cohort of 3733 women was interviewed during early pregnancy. We ascertained participants' self-reported history of physician-diagnosed migraine and collected self-reported information about pregravid weight, adult height, and net weight change from age 18 to the 3-months period before pregnancy. Using pregravid body mass index, we categorized participants as follows: lean (< 18.5 kg/m²), normal (18.5-24.9 kg/m²), overweight (25-29.9 kg/m²), obese (30-34.9 kg/m²), severely obese (35-39.9 kg/m²), and morbidly obese (≥ 40 kg/m²). Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).


RESULTS
After adjusting for confounders, relative to normal weight women, obese women had a 1.48-fold increased odds of migraine (OR = 1.48; 95% CI 1.12-1.96). Severely obese (OR = 2.07; 95% CI 1.27-3.39) and morbidly obese (OR = 2.75; 95% CI 1.60-4.70) had the highest odds of migraines. Women with a history of diagnosed pediatric migraine had a 1.67-fold higher odds of gaining ≥ 10.0 kg above their weight at age 18, as compared with non-migraineurs (OR = 1.67; 95% CI 1.13-2.47).


CONCLUSIONS
These data support earlier observations of migraine-obesity association among women, and extend the literature to include evidence of adult weight gain among women with a history of pediatric migraine.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Michelle
M
Vo
Abinnet
A
Ainalem
Chunfang
C
Qiu
B Lee
BL
Peterlin
Sheena K
SK
Aurora
Michelle A
MA
Williams
D000328:Adult; D000375:Aging / Q000502:physiology*; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D011247:Pregnancy; D011446:Prospective Studies; D012098:Reproduction / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology*
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