Evaluation of the relationship between chromosome aberrations and transcription activity of nucleolus organizer regions in indigenous population of the Kursk region.
The relationship between activity of chromosomal nucleolus-organizer regions and levels of chromosome aberrations was studied in 215 residents of the Kursk region by visual semiquantitative method (silver staining of the nucleolus-organizer regions, NOR) in chromosomes of peripheral blood lymphocytes. The levels of chromosome aberrations differed significantly in three groups differing by the levels of 10AgNOR, which can be explained by different proliferative activity in these groups. The lowest level of chromosome aberrations was found in subjects with high transcription activity of NOR, presumably due to high proliferative activity in this group and more intensive synthesis of proteins, including the reparation enzymes. The highest level of chromosome aberrations was detected in the group with the medium level of 10AgNOR.
Kursk Institute of Social Formation, Affiliated Department of the Russian State Social University, Russia. zsyu@046.ru
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Medvedev
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Amelina
D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D009697:Nucleolus Organizer Region / Q000502:physiology*; D044382:Population Groups / Q000235:genetics*; D012426:Russia; D016622:Silver Staining; D014158:Transcription, Genetic / Q000502:physiology*