Oncocytoma of the kidney with prominent intracytoplasmic lumina.
Oncocytoma is a histologically distinctive neoplasm of the kidney, with a well-recognized cytoarchitectural appearance. On occasion, however, renal oncocytomas are known to exhibit unusual morphologic features that may pose diagnostic difficulties. We present the clinical and pathologic details of an oncocytoma of the kidney with an unusual histologic appearance imparted by the presence of large numbers of prominent intracytoplasmic lumens. Morphologically, the neoplasm was composed of uniform polygonal cells with copious amounts of granular, eosinophilic cytoplasm, round nuclei, and prominent nucleoli, exhibiting an organoid pattern of growth. Intracytoplasmic lumina of varying size were present throughout the tumor. There were no mitotic figures or areas of necrosis present. The diagnosis of oncocytoma was supported by immunohistochemical and ultrastructural studies. By electron microscopy, the intracytoplasmic lumens appeared as membrane bound spaces with associated microvilli. The presence of intracytoplasmic lumina in a significant proportion of cells is an uncommon feature of renal oncocytoma which can generate problems in diagnosis. Awareness of this phenomenon should allow for improved recognition of oncocytomas exhibiting this type of unusual morphology.
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA. slau@coh.org
Sean K
SK
Lau
Arthur H
AH
Cohen
Daniel J
DJ
Luthringer
D018249:Adenoma, Oxyphilic / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged