Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science.
A variety of cytokines play a role in the response to an inflammatory stimulus. The interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus. They act locally and systemically to generate a variety of physiologic responses, principal among them is the acute phase response. The IL-6 type cytokines demonstrate pleiotropy and redundancy of actions. This is made possible by the distinctive characteristics of the IL-6 receptor complex, which contains an ubiquitous subunit that is shared by most IL-6-type cytokines, as well as a cytokine-specific subunit.
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA. rjawa@unmc.edu
Randeep S
RS
Jawa
Sergio
S
Anillo
Kristin
K
Huntoon
Heinz
H
Baumann
Mahmoud
M
Kulaylat
D003422:Critical Care; D013502:General Surgery; D006801:Humans; D015850:Interleukin-6 / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D019947:Receptors, Interleukin-6 / Q000737:chemistry / Q000378:metabolism; D018805:Sepsis / Q000276:immunology; D014947:Wounds and Injuries / Q000276:immunology*
D015850:Interleukin-6; D019947:Receptors, Interleukin-6
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