Clinical characteristics of malignant pericardial effusion associated with recurrence and survival.
OBJECTIVE
We evaluated clinical outcomes after drainage for malignant pericardial effusion with imminent or overt tamponade.


METHODS
Between August 2001 and June 2007, 100 patients underwent pericardiocentesis for malignant pericardial effusion. Adequate follow-up information on the recurrence of pericardial effusion and survival status was available for 98 patients.


RESULTS
Recurrence of effusion occurred in 30 patients (31%), all of whom were diagnosed with adenocarcinoma. Multivariate analysis indicated that adenocarcinoma of the lung (hazard ratio [HR], 6.6; 95% confidence interval [CI], 1.9 to 22.3; p=0.003) and progressive disease despite chemotherapy (HR, 4.3; 95% CI, 1.6 to 12.0; p=0.005) were independent predictors of recurrence. Survival rates three months after pericardiocentesis differed significantly with the type of primary cancer; the rates were 73%, 18%, 90% and 30% in patients with adenocarcinoma of the lung, squamous cell carcinoma of the lung, breast cancer and other cancers, respectively.


CONCLUSIONS
Recurrence and survival of patients with malignant pericardial effusion are dependent on the type of primary cancer and response to chemotherapy. Patients with adenocarcinoma of the lung may be good candidates for surgical drainage to avoid repeated pericardiocentesis, but pericardiocentesis is considered effective as palliative management in patients with other cancers.
Cardiology Clinic, National Cancer Center, Goyang, Korea.
Sung-Hwan
SH
Kim
Mi Hyang
MH
Kwak
Sohee
S
Park
Hak Jin
HJ
Kim
Hyun-Sung
HS
Lee
Moon Soo
MS
Kim
Jong Mog
JM
Lee
Jae Ill
JI
Zo
Jung Sil
JS
Ro
Jin Soo
JS
Lee
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