Etiology of syncope in patients hospitalized with syncope and predictors of mortality and rehospitalization for syncope at 27-month follow-up.
The authors investigated the etiologies of syncope and risk factors for mortality and rehospitalization for syncope at 27-month follow-up in 325 consecutive patients, mean age 66 years, hospitalized for syncope. The causes of syncope were diagnosed in 241 patients (74%). Of 325 patients, 13 (4%) were rehospitalized for syncope and 38 (12%) died. Stepwise logistic regression analysis showed that significant independent prognostic factors for rehospitalization for syncope were diabetes (odds ratio [OR], 5.7; 95% confidence interval [CI], 1.6-20.4), atrial fibrillation (OR, 4.0; 95% CI, 1.0-15.6), and smoking (OR, 4.6; 95% CI, 1.3-16.8). Stepwise Cox regression analysis showed that significant independent prognostic factors for time to mortality were diabetes (hazard ratio [HR], 2.7; 95% CI, 1.4-5.2), coronary artery bypass graft surgery (HR, 2.9; 95% CI, 1.3-6.5), malignancy history (HR, 2.5; 95% CI, 1.2-5.2), narcotics use (HR, 4.0; 95% CI, 1.7-9.8), smoking (HR, 2.8; 95% CI, 1.4-5.5), atrial fibrillation (HR, 2.4; 95% CI, 1.0-5.4), and volume depletion (HR, 2.8; 95% CI, 1.4-5.8). Copyright © 2011 Wiley Periodicals, Inc. The authors have no funding, financial relationships, or conflicts of interest to disclose.
Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York, USA.
Sachin
S
Sule
Chandrasekar
C
Palaniswamy
Wilbert S
WS
Aronow
Chul
C
Ahn
Stephen J
SJ
Peterson
Sreedhar
S
Adapa
Lakshmi
L
Mudambi
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010359:Patient Readmission; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D013575:Syncope / Q000209:etiology* / Q000401:mortality* / Q000628:therapy; D013997:Time Factors
Heart. 2008 Dec;94(12):1620-6
18519550
J Am Coll Cardiol. 2008 Jan 22;51(3):276-83
18206736
Clin Auton Res. 1996 Apr;6(2):125-6
8726100
Lancet. 1995 Oct 7;346(8980):950-2
7564734
Ann Emerg Med. 2004 Feb;43(2):224-32
14747812
Ann Emerg Med. 2008 May;51(5):585-90
17889403
JAMA. 1992 Nov 11;268(18):2553-60
1404823
Am J Cardiol. 2005 Mar 1;95(5):668-71
15721118
Arch Intern Med. 2009 Jul 27;169(14):1299-305
19636031
Eur Heart J. 2003 May;24(9):811-9
12727148
Emerg Med J. 2007 Apr;24(4):270-5
17384381