Traffic exposure and incident venous thromboembolism in the Atherosclerosis Risk in Communities (ARIC) Study.
BACKGROUND
Two recent case-control studies in Italy reported that long-term exposure to particulate air pollution or living near major traffic roads was associated with an increased risk of deep vein thrombosis (DVT). No prospective evidence exists on the possible association between long-term traffic-related air pollution and incident venous thromboembolism (VTE).


OBJECTIVE
To examine the association between long-term traffic exposure and incident VTE in a population-based prospective cohort study.


METHODS
We studied 13,143 middle-aged men and women in the Atherosclerosis Risk in Communities Study without a history of DVT or pulmonary embolism at baseline examination (1987-1989). The Geographical Information System-mapped traffic density and distance to major roads in the four study communities served as measures of traffic exposure. We examined the association between traffic exposure and incident VTE with proportional hazards regression models.


RESULTS
A total of 405 subjects developed VTE in 2005. Traffic density was not significantly associated with VTE. Relative to those in the lowest quartile of traffic density, the adjusted hazard ratios across increasing quartiles were 1.18 (95% confidence interval [CI] 0.88-1.57), 0.99 (95% CI 0.74-1.34) and 1.14 (95% CI 0.86-1.51) (P-value for trend across quartiles = 0.64). For residents living within 150 m of major roads, as compared with subjects living further away, the adjusted hazard ratio was 1.16 (95% CI 0.95-1.42, P = 0.14).


CONCLUSIONS
This first prospective study in the general population does not support an association between air pollution exposure or traffic proximity and risk of DVT. More data may be needed to clarify whether traffic or air pollution influences the risk of VTE.
School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Institute of Global Environmental Change Research, Fudan University, Shanghai, China.
H
H
Kan
A R
AR
Folsom
M
M
Cushman
K M
KM
Rose
W D
WD
Rosamond
D
D
Liao
F
F
Lurmann
S J
SJ
London
D050197:Atherosclerosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D001335:Vehicle Emissions / Q000633:toxicity*; D054556:Venous Thromboembolism / Q000209:etiology*
D001335:Vehicle Emissions
J Thromb Haemost. 2010 Apr;8(4):669-74
20088925
Am J Epidemiol. 1989 Apr;129(4):687-702
2646917
Am J Med. 2004 Jul 1;117(1):19-25
15210384
Environ Health Perspect. 2011 Mar;119(3):326-31
21036692
JAMA. 2002 Mar 6;287(9):1132-41
11879110
Int J Health Geogr. 2004 Nov 17;3(1):27
15548332
J Expo Anal Environ Epidemiol. 2001 Nov-Dec;11(6):459-69
11791163
N Engl J Med. 1999 Mar 25;340(12):955-6
10089190
JAMA. 1998 Jan 14;279(2):119-24
9440661
J Thromb Haemost. 2010 Apr;8(4):662-8
19922434
Thorax. 2007 Oct;62(10):873-9
17442705
Lancet. 1996 Oct 12;348(9033):977-80
8855852
Circulation. 2008 Jan 1;117(1):93-102
18086925
Circulation. 2009 Jun 23;119(24):3118-24
19506111
J Allergy Clin Immunol. 2005 Aug;116(2):279-84
16083780
Arch Intern Med. 2002 May 27;162(10):1182-9
12020191
Lancet. 2002 Oct 19;360(9341):1203-9
12401246
Arch Intern Med. 2008 May 12;168(9):920-7
18474755
Eur Heart J. 2006 Nov;27(22):2696-702
17003049
Circulation. 2010 Jun 1;121(21):2331-78
20458016
Circulation. 2004 Jun 1;109(21):2655-71
15173049
Respir Res. 2005 Dec 22;6:152
16372913
Thorax. 1999 Dec;54(12):1070-4
10567625
Am J Respir Crit Care Med. 2001 Dec 15;164(12):2177-80
11751183
Environ Health Perspect. 2008 Nov;116(11):1463-8
19057697