Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients.
OBJECTIVE
S100A12 is an endogenous receptor ligand for advanced glycation end products. Cardiovascular disease remains a major cause of morbidity and mortality in patients with chronic kidney disease. In this study, we report cross-sectional data on 550 hemodialysis patients and assess the relationship between plasma S100A12 level and cardiovascular disease.


METHODS
A cross-sectional study of 550 maintenance hemodialysis patients was conducted. We investigated the past history of cardiovascular disease and quantified the plasma level of S100A12 protein in all participants.


RESULTS
Plasma S100A12 level was higher in hemodialysis patients with cardiovascular disease (n=197; 33.8 ± 28.1 ng/ml) than in those without it (n=353; 20.2 ± 16.1 ng/ml; P<0.001). In multivariate logistic regression analysis, the plasma S100A12 level (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.13 to 1.44; P<0.001) was identified as an independent factor associated with the prevalence of cardiovascular disease. The other factors associated with the prevalence of cardiovascular diseases were the presence of diabetes mellitus (OR, 2.81; 95% CI, 1.79 to 4.41; P < 0.001) and high-sensitivity CRP level (OR, 1.02; 95% CI, 1.00 to 1.05; P=0.046). Furthermore, the plasma S100A12 level (OR, 1.30; 95% CI, 1.09 to 1.54; P=0.004) was significantly associated with cardiovascular disease even in hemodialysis patients without diabetes mellitus (n=348).


CONCLUSIONS
These results suggest that the plasma S100A12 protein level is strongly associated with the prevalence of cardiovascular disease in hemodialysis patients.
Department of Cardiology and Nephrology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto 608-8566, Japan.
Yayoi
Y
Shiotsu
Yasukiyo
Y
Mori
Masato
M
Nishimura
Chikako
C
Sakoda
Toshiko
T
Tokoro
Tsuguru
T
Hatta
Noboru
N
Maki
Kumiko
K
Iida
Noriyuki
N
Iwamoto
Toshihiko
T
Ono
Eiko
E
Matsuoka
Noriko
N
Kishimoto
Keiichi
K
Tamagaki
Hiroaki
H
Matsubara
Atsushi
A
Kosaki
D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood; D006435:Renal Dialysis; D009418:S100 Proteins / Q000097:blood* / Q000502:physiology; D000067616:S100A12 Protein
D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human
Int J Biochem Cell Biol. 2001 Jul;33(7):637-68
11390274
Lancet. 2003 Apr 12;361(9365):1270-2
12699958
Semin Dial. 2002 Sep-Oct;15(5):329-37
12358637
J Clin Endocrinol Metab. 2004 Nov;89(11):5423-8
15531492
Am J Med Sci. 2003 Apr;325(4):163-7
12695721
N Engl J Med. 1999 Jan 14;340(2):115-26
9887164
Atherosclerosis. 2009 Dec;207(2):597-602
19576587
Nat Clin Pract Nephrol. 2008 Dec;4(12):672-81
18825155
J Am Soc Nephrol. 2004 Jul;15(7):1889-96
15213278
Microsc Res Tech. 2003 Apr 15;60(6):581-92
12645006
Semin Dial. 2009 Jul-Aug;22(4):400-4
19708990
Kidney Int. 2008 Nov;74(10):1335-42
18769368
Circ Res. 2010 Jan 8;106(1):145-54
19875725
Cell. 1999 Jun 25;97(7):889-901
10399917
Atherosclerosis. 2003 Dec;171(2):211-8
14644389
J Immunol. 2009 Jul 1;183(1):593-603
19542470
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):147-53
17082489
Blood Purif. 2001;19(1):53-61
11114578
J Leukoc Biol. 2001 Jun;69(6):986-94
11404386
Clin J Am Soc Nephrol. 2008 Mar;3(2):505-21
18184879
J Transl Med. 2009 Mar 17;7:17
19292913
Gut. 2003 Jun;52(6):847-53
12740341
Ther Apher Dial. 2008 Feb;12(1):28-32
18257809
J Am Coll Cardiol. 2009 Jun 9;53(23):2129-40
19497438
J Clin Endocrinol Metab. 2006 Nov;91(11):4628-34
16926247
Amino Acids. 2009 Mar;36(3):381-9
18443896
Arthritis Res Ther. 2009;11(2):R39
19284577
Am J Nephrol. 2009;29(1):18-24
18663285
Rheumatology (Oxford). 2003 Nov;42(11):1383-9
12832707
Circulation. 2003 Oct 28;108(17):2154-69
14581387