Assessment of qualitative changes of Acid mucins among sudanese colorectal carcinoma patients.
OBJECTIVE
This study aimed to assess the qualitative changes in the amount of acid mucin in colorectal carcinoma (CRC) compared to normal colon.


METHODS
A total number of 100 samples were examined, 50 were colorectal cancer samples (cases) and 50 were normal (controls), all were stained with Alcian blue method.


RESULTS
Acid mucin increased, in different levels, in 30 (60%) of the cases compared to only six (12%) of controls (P < 0.0001). However, complete absence of acid mucin was detected among 10 (20%) of cases compared to none among controls.


CONCLUSIONS
CRC is associated with secretion of increased amounts of acid mucin in most cases, and that should be considered as a valuable histological finding.
Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, P.O. Box 11081, Khartoum, 11111, Sudan. yosifzakot@yahoo.com
Yosef Mohamed-Azzam
YM
Zakout
Yousra Altegani
YA
Ezeldeen
D000230:Adenocarcinoma / Q000378:metabolism*; D000423:Alcian Blue; D015179:Colorectal Neoplasms / Q000378:metabolism*; D004396:Coloring Agents; D006801:Humans; D009077:Mucins / Q000032:analysis*; D013397:Sudan
D004396:Coloring Agents; D009077:Mucins; D000423:Alcian Blue
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