Dual effects of erdosteine on hemostasis via its different metabolites in young rats.
OBJECTIVE
In the study, we examined erdosteine's effects on platelet functions and coagulation.


METHODS
A total 29 young albino Wistar rats were divided into four groups. Control rats (n = 6) were given saline; Group 1 rats (n = 7) were given 3 mg/kg erdosteine by oral gavage for 3 days; Group 2 rats (n = 7) were given 10 mg/kg erdosteine by oral gavage for 3 days; and Group 3 rats (n = 9) were given 30 mg/kg erdosteine for 3 days. Twenty-four hours after the final dose, blood samples were drawn from a portal vein. Prothrombin time (PT), activated partial thromboplastin time (aPTT) and international normalized ratio (INR) were measured, and platelet counts were examined in a peripheral blood smear by light microscopy.


RESULTS
PT and INR values of Group 1 increased compared to the controls but did not change in Group 3. Hemostatic parameters were not measured in Group 2 because the blood samples in Group 2's tubes clotted rapidly. Platelet counts of the peripheral blood from Group 2 were low but were normal in other groups.


CONCLUSIONS
We have concluded erdosteine may disrupt hemostasis parameters by its different metabolites in patients. Erdosteine has dual effects on hemostasis via its different metabolites, which occur in different doses.
Department of Pediatrics, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey. vefikarica@hotmail.com
Vefik
V
Arica
Murat
M
Tutanc
Oktay Hasan
OH
Ozturk
Secil
S
Arica
Fatmagul
F
Basarslan
Ersin Sukru
ES
Erden
Suleyman
S
Oktar
Hasan
H
Kaya
D000818:Animals; D005100:Expectorants / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D019934:International Normalized Ratio; D010976:Platelet Count; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar; D013864:Thioglycolates / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
D005100:Expectorants; D013864:Thioglycolates; D013876:Thiophenes; C048498:erdosteine