Allergy and psychologic evaluations of patients with multiple drug intolerance syndrome.
The multiple drug intolerance syndrome is a clinical entity characterized by adverse drug reactions to at least three drugs, chemically, pharmacologically and immunogenically unrelated, manifested upon three different occasions, and with negative allergy testing. Symptoms referred by the patients are often subjective, of neurovegetative origin. The aim of the study is to characterize patients suffering from the multiple drug intolerance syndrome from a psychological point of view, and to compare them to healthy subjects. We studied 30 women suffering from the multiple drug intolerance syndrome. All subjects underwent the following psychodiagnostic tests: (1) the State Trait Anxiety Inventory-Form Y, (2) the Zung Self-rating Anxiety Scale, (3) the Zung Self-rating Depression Scale, (4) the Quality of life enjoyment and satisfaction questionnaire, (5) the Minnesota Multiphasic Inventory-2, (6) the Toronto Alexithymia Scale. The study group was compared to 30 healthy women. When compared with the control group, our patients showed: a higher anxiety, a higher grade of depression, this difference was statistically significant (p < 0.01); a high difference (p < 0.01) between the two groups as regards somatic symptoms; a higher grade of alexithymia (p < 0.01); and a worse quality of life, in all the analyzed ambits. These findings clearly demonstrate the importance of psychological symptoms in patients with the multiple drug intolerance syndrome, and show that a complex allergy and psychological work-up is mandatory in the management of these patients.
Department of Allergology, Catholic Univeristy of the Sacred Heart, Rome, Italy.
Tiziana
T
De Pasquale
Eleonora
E
Nucera
Rocco
R
Boccascino
Petronilla
P
Romeo
Giuseppe
G
Biagini
Alessandro
A
Buonomo
Amira
A
Colagiovanni
Valentina
V
Pecora
Arianna
A
Aruanno
Angela
A
Rizzi
Carla
C
Lombardo
Vito
V
Sabato
Giovanni
G
Gasbarrini
Giampiero
G
Patriarca
Domenico
D
Schiavino
D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011584:Psychology; D012016:Reference Values; D018570:Risk Assessment; D013577:Syndrome; D055815:Young Adult
Int J Clin Pharmacol Biopharm. 1976 Apr;13(3):187-95
950261
J Psychosom Res. 1994 Feb;38(2):119-27
8189401
Psychother Psychosom. 1973;22(2):255-62
4770536
Ann Allergy Asthma Immunol. 2007 Aug;99(2):136-42
17718101
Psychother Psychosom. 2004 Mar-Apr;73(2):68-77
14767148
Psychopharmacol Bull. 1993;29(2):321-6
8290681
J Investig Allergol Clin Immunol. 1991 Apr;1(2):138-44
1669570
Allergy. 2002 Jan;57(1):45-51
11991289
Allergy. 2001 Sep;56(9):813-24
11551246
Recenti Prog Med. 1980 Jan;68(1):21-33
6102782
Psychosom Med. 1988 Sep-Oct;50(5):500-9
3186893
Can J Clin Pharmacol. 2004 Spring;11(1):e8-16
15226522
Psychosomatics. 1971 Nov-Dec;12(6):371-9
5172928
Eur Ann Allergy Clin Immunol. 2005 Mar;37(3):90-5
15918295
Arch Gen Psychiatry. 1965 Dec;13(6):508-15
4378854