Eicosapentaenoic and docosahexaenoic acids enriched polyunsaturated fatty acids from the coastal marine fish of Bay of Bengal and their therapeutic value.
Eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) enriched polyunsaturated fatty acids (PUFA) significantly present in marine fish oil emerge as preventive agents for combating many health problems specially in chronic or metabolic disorders. The fish in the coastal area of Bay of Bengal has remained unexplored with respect to EPA/DHA enriched PUFA content in its oils, although it may be a potential source in harnessing the health benefit. In this study, seven varieties of the coastal fish were analysed for the content of EPA/DHA. The one locally known as lotte, (Harpadon nehereus) though has low content of total lipids, was found to have high EPA/DHA in its oil. The phospholipids rich fraction was extracted from the total fish oil. The EPA/DHA enriched PUFA was isolated to investigate the potential use for health benefits. EPA/DHA is found to act as protective agent against mercury poisoning studied in cell culture as well as in animal mode. It is found to be highly preventive in diabetes. The lotte is available in the coastal area of Bay of Bengal adjoining West Bengal, India in large scale and it is the first report showing EPA/DHA enriched PUFA in these fish oil that can be availed to harness in important health benefits.
Division of Molecular Medicine, Bose Institute, P-1/12, C.I.T. Scheme VII-M, Kolkata 700 054.
Rabindranath
R
Bera
Tushar K
TK
Dhara
Ranjan
R
Bhadra
Gopal C
GC
Majumder
Parimal C
PC
Sen
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D004281:Docosahexaenoic Acids / Q000302:isolation & purification / Q000627:therapeutic use*; D015118:Eicosapentaenoic Acid / Q000302:isolation & purification / Q000627:therapeutic use*; D004847:Epithelial Cells / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000627:therapeutic use*; D005399:Fishes; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008055:Lipids / Q000032:analysis; D008297:Male; D008627:Mercuric Chloride / Q000633:toxicity*; D051381:Rats; D013552:Swine
D000891:Anti-Infective Agents, Local; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D004281:Docosahexaenoic Acids; D008627:Mercuric Chloride; D015118:Eicosapentaenoic Acid