Syndecan expressions in the human amnion and chorionic plate.
The syndecan family consists of four distinct membrane glycoproteins in mammals. Syndecans control cell proliferation, differentiation, adhesion and migration through participation in cell-cell interactions, anchorage of cells to the extracellular environment, and modulation of multiple growth factors. Therefore, syndecans may play a pivotal role in the regulation of cell behaviour depending on the cellular microenvironment. Here, we demonstrate that syndecan-1, syndecan-2 and syndecan-4 are expressed in fetal membrane tissue with different immunolocalizations. Syndecan-1 is expressed in the amniotic epithelium, localizing at basolateral cell surfaces. Syndecan-2 and syndecan-4, in contrast, are mostly localized in intracellular compartments, in the extravillous cytotrophoblastic cells and in some fibroblasts of the chorionic plate as well as in the amniotic epithelial cells. In the latter, syndecan-4 is mainly localized in the apical part of the cells. Our results strongly suggest a key role of syndecan-1, syndecan-2 and syndecan-4 in the determination of structural and functional characteristics of human amnion and chorionic plate. Since the solute exchanges between fetus and mother take place in fetal membranes, our data suggest that syndecans are important players in the placenta for the establishment of the fetal-maternal inter-communication.
Department of Molecular Pathology and Innovative Therapies, Anatomy and Cell Biology, Faculty of Medicine, Marche Polytechnic University, Ancona, Italy. t.lorenzi@univpm.it
T
T
Lorenzi
A
A
Turi
C
C
Crescimanno
M
M
Morroni
M
M
Castellucci
G
G
David
A L
AL
Tranquilli
D
D
Marzioni
D000650:Amnion / Q000166:cytology / Q000378:metabolism*; D002823:Chorion / Q000166:cytology / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy; D053668:Syndecan-1 / Q000378:metabolism*; D053669:Syndecan-2 / Q000378:metabolism*; D053671:Syndecan-4 / Q000378:metabolism*
C508241:SDC1 protein, human; C508304:SDC4 protein, human; D053668:Syndecan-1; D053671:Syndecan-4; D053669:Syndecan-2
Acta Physiol Scand Suppl. 1957;40(137):1-84
13424334
Trends Cell Biol. 1998 May;8(5):189-92
9695837
Matrix Biol. 2003 Mar;22(1):25-33
12714039
Int Rev Cytol. 2001;207:113-50
11352265
J Biol Chem. 2006 May 26;281(21):14533-6
16574663
J Cell Biol. 2002 May 13;157(4):715-25
12011116
J Biol Chem. 1995 Mar 10;270(10):5077-83
7890615
Int J Biochem Cell Biol. 2000 Mar;32(3):269-88
10716625
Dev Biol. 1990 Jul;140(1):83-92
2358126
Annu Rev Biochem. 1999;68:729-77
10872465
J Pathol. 1999 Dec;189(4):600-8
10629564
J Cell Biochem. 1996 Jun 15;61(4):578-84
8806081
Adv Anat Embryol Cell Biol. 1992;127:1-100
1514435
Matrix Biol. 2006 Sep;25(7):443-56
16934444
J Cell Sci. 1999 Oct;112 ( Pt 20):3421-31
10504291
J Biol Chem. 2003 Feb 28;278(9):7617-23
12493766
J Cell Biol. 1998 Jul 13;142(1):129-38
9660868
J Biol Chem. 1997 May 2;272(18):11805-11
9115237
Dev Biol. 1988 Oct;129(2):565-72
3417053
J Cell Biol. 1992 Aug;118(4):961-9
1500433
J Biol Chem. 1997 Mar 28;272(13):8133-6
9079625
J Biol Chem. 1989 Apr 25;264(12):7009-16
2523387
Development. 1993 Nov;119(3):841-54
8187643
Dev Suppl. 1993;:205-12
8049475
J Pathol. 1994 Apr;172(4):349-55
8207616
J Cell Physiol. 1998 Mar;174(3):310-21
9462693
Ann N Y Acad Sci. 2007 Apr;1101:166-85
17332077
Cell Tissue Res. 1996 Jul;285(1):101-7
8766863
J Biol Chem. 1997 Jul 18;272(29):18418-24
9218485
Nat Rev Mol Cell Biol. 2003 Dec;4(12):926-37
14685171
Mol Biol Cell. 1995 May;6(5):559-76
7545031
Biochem Biophys Res Commun. 2003 Jul 25;307(2):355-61
12859964
Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):932-6
1736308
Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):627-38
19822079