Do intra-operative fluids influence the need for post-operative cardiotropic support after a PDA ligation?
OBJECTIVE
To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic stability.


METHODS
We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus (PDA) ligation in one NICU between 2001 and 2007. The primary outcome was the need for cardiotropic support within 24 hrs of ligation.


RESULTS
Twenty-seven infants (28%) required post-operative cardiotropic support. The amount of intra-operative fluids varied between 0 and 50.4 mL/kg (median: 10.2 mL/kg). No intra-operative fluid was recorded in 26 patients. Fluids were not associated with the need for post-operative cardiotropic support (P=0.10). Using a multivariate logistic regression model, age at ligation, weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic support.


CONCLUSIONS
Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support. A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.
Department of Pediatrics, University of Ottawa, Ottawa, Canada. blemyre@toh.on.ca
Brigitte
B
Lemyre
Ling
L
Liu
Gregory Paul
GP
Moore
Sarah Linda
SL
Lawrence
Nicholas J
NJ
Barrowman
D015331:Cohort Studies; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology / Q000601:surgery*; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008026:Ligation; D012189:Retrospective Studies