Current concepts: mouse models of Sjögren's syndrome.
Sjögren's syndrome (SjS) is a complex chronic autoimmune disease of unknown etiology which primarily targets the exocrine glands, resulting in eventual loss of secretory function. The disease can present as either primary SjS or secondary SjS, the latter of which occurs concomitantly with another autoimmune disease such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma, or primary biliary cirrhosis. Current advancements in therapeutic prevention and treatment for SjS are impeded by lack of understanding in the pathophysiological and clinical progression of the disease. Development of appropriate mouse models for both primary and secondary SjS is needed in order to advance knowledge of this disease. This paper details important features, advantages, and pitfalls of current animal models of SjS, including spontaneous, transgenic, knockout, immunization, and transplantation chimera mouse models, and emphasizes the need for a better model in representing the human SjS phenotype.
Department of Oral Biology, College of Dentistry, University of Florida, P.O. Box 100424, 1600 SW Archer Road, Gainesville, FL 32610, USA.
Tegan N
TN
Lavoie
Byung Ha
BH
Lee
Cuong Q
CQ
Nguyen
D000818:Animals; D002678:Chimera; D004195:Disease Models, Animal; D006801:Humans; D007114:Immunization; D051379:Mice; D008822:Mice, Transgenic; D012859:Sjogren's Syndrome / Q000473:pathology*; D014180:Transplantation
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