[Methotrexate toxicity. Myths and facts].
Methotrexate (MTX) is a safe and well-tolerated drug for the treatment of rheumatic diseases, even if the strictest safety standards are considered. Initial apprehension as to severe pulmonary or hepatic side-effects has not been confirmed. The risk of infection is not elevated compared with other disease-modifying antirheumatic drugs. In addition, a mutagenic potential could not be demonstrated even after long-term application. Therefore, MTX will maintain its significant role in antirheumatic therapy also in the near future.
Department für Innere Medizin, Klinik für Innere Medizin II/Arbeitsbereich Rheumatologie, Universitätsklinik Halle (Saale), Halle (Saale), Germany. gernot.keyszer@medizin.uni-halle.de
G
G
Keysser
D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D019317:Evidence-Based Medicine; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use*; D011014:Pneumonia / Q000139:chemically induced*; D018570:Risk Assessment
D018501:Antirheumatic Agents; D008727:Methotrexate
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