Pharmacokinetics and antitumor effects of the drug containing TNF-α in nanoparticles.
Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation of the cytokine in the blood and its more intensive accumulation by tumor tissue.
Institute of Medical Biotechnology, Vector Center of Virology and Biotechnology, Novosibirsk Region, Berdsk, Russia. gamalei58@mail.ru
S G
SG
Gamaley
A V
AV
Bateneva
G M
GM
Sysoeva
E D
ED
Danilenko
L R
LR
Lebedev
V I
VI
Masycheva
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D007273:Injections, Intramuscular; D051379:Mice; D008813:Mice, Inbred ICR; D053758:Nanoparticles; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha