Temporary disruption of fear-potentiated startle following PKMζ inhibition in the amygdala.
We examined whether protein kinase M zeta (PKMζ) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKMζ blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKMζ inhibition does not erase memory, but temporarily disrupts expression of memory.
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA. rparso3@emory.edu
Ryan G
RG
Parsons
Michael
M
Davis
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology; D005239:Fear / Q000502:physiology*; D008568:Memory / Q000502:physiology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D051381:Rats; D013216:Reflex, Startle / Q000502:physiology*
D011493:Protein Kinase C; C504730:protein kinase M zeta, rat
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