Cardiorespiratory fitness and attentional control in the aging brain.
A growing body of literature provides evidence for the prophylactic influence of cardiorespiratory fitness on cognitive decline in older adults. This study examined the association between cardiorespiratory fitness and recruitment of the neural circuits involved in an attentional control task in a group of healthy older adults. Employing a version of the Stroop task, we examined whether higher levels of cardiorespiratory fitness were associated with an increase in activation in cortical regions responsible for imposing attentional control along with an up-regulation of activity in sensory brain regions that process task-relevant representations. Higher fitness levels were associated with better behavioral performance and an increase in the recruitment of prefrontal and parietal cortices in the most challenging condition, thus providing evidence that cardiorespiratory fitness is associated with an increase in the recruitment of the anterior processing regions. There was a top-down modulation of extrastriate visual areas that process both task-relevant and task-irrelevant attributes relative to the baseline. However, fitness was not associated with differential activation in the posterior processing regions, suggesting that fitness enhances attentional function by primarily influencing the neural circuitry of anterior cortical regions. This study provides novel evidence of a differential association of fitness with anterior and posterior brain regions, shedding further light onto the neural changes accompanying cardiorespiratory fitness.
Department of Psychology, The Ohio State University Columbus, OH, USA.
Ruchika Shaurya
RS
Prakash
Michelle W
MW
Voss
Kirk I
KI
Erickson
Jason M
JM
Lewis
Laura
L
Chaddock
Edward
E
Malkowski
Heloisa
H
Alves
Jennifer
J
Kim
Amanda
A
Szabo
Siobhan M
SM
White
Thomas R
TR
Wójcicki
Emily L
EL
Klamm
Edward
E
McAuley
Arthur F
AF
Kramer
Neuroscience. 2004;124(1):71-9
14960340
Neuropsychologia. 2010 Apr;48(5):1394-406
20079755
Neuroimage. 2003 Oct;20(2):693-712
14568445
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
17167157
Behav Brain Res. 1991 Dec 20;46(2):123-33
1664728
Neuroimage. 2005 Nov 15;28(3):635-62
16172003
Neuropsychologia. 2001;39(12):1367-71
11566318
Nat Neurosci. 2000 May;3(5):509-15
10769393
Brain Res. 2010 Jun 23;1341:41-51
19560443
Neuroimage. 2002 Nov;17(3):1394-402
12414279
Brain Cogn. 2009 Dec;71(3):328-35
19699019
J Gerontol A Biol Sci Med Sci. 2003 Feb;58(2):176-80
12586857
Neuroreport. 2001 Jul 3;12(9):2065-71
11435947
Nat Neurosci. 1999 Mar;2(3):266-70
10195220
Brain Res Cogn Brain Res. 2001 Dec;12(3):467-73
11689307
Neurobiol Aging. 2007 Feb;28(2):272-83
16480789
Brain Res. 2002 Apr 26;934(1):1-6
11937064
Magn Reson Med. 2003 Jan;49(1):193-7
12509838
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13091-5
15322270
Science. 1990 Jun 22;248(4962):1556-9
2360050
Eur J Neurosci. 2004 Nov;20(10):2580-90
15548201
Trends Neurosci. 2007 Sep;30(9):464-72
17765329
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22552-7
20018709
Neuromolecular Med. 2008;10(2):47-58
18535925
Neuropsychologia. 1993 Sep;31(9):907-22
8232848
Hum Brain Mapp. 2002 Nov;17(3):143-55
12391568
Neuroimage. 2004 Apr;21(4):1732-47
15050594
Neuroimage. 2004 Jan;21(1):192-200
14741656
Hippocampus. 2009 Oct;19(10):1030-9
19123237
Acta Physiol Scand. 1989 Jul;136(3):473-81
2473602
Curr Opin Neurobiol. 2005 Apr;15(2):245-51
15831410
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3316-21
14978288
Eur J Neurosci. 2003 Nov;18(10):2803-12
14656329
Neurosci Biobehav Rev. 2002 Nov;26(7):819-25
12470693
Psychol Aging. 2005 Sep;20(3):363-75
16248697
Hum Brain Mapp. 1998;6(4):270-82
9704265
Cereb Cortex. 2006 Jun;16(6):827-34
16135781
J Int Neuropsychol Soc. 1999 May;5(4):308-19
10349294
J Neurosci. 1994 Mar;14(3 Pt 2):1450-62
8126548
Psychol Sci. 2003 Mar;14(2):125-30
12661673
J Cogn Neurosci. 2003 May 15;15(4):600-9
12803970
Proc Natl Acad Sci U S A. 1990 Jul;87(14):5568-72
1695380
Psychol Aging. 2002 Mar;17(1):24-43
11931285
Exp Neurol. 2005 May;193(1):181-97
15817277
Eur J Appl Physiol. 2007 Mar;99(5):533-40
17219173
Med Sci Sports Exerc. 1987 Jun;19(3):253-9
3600239
J Neurosci. 2001 Mar 1;21(5):1628-34
11222653
Nat Neurosci. 2000 Apr;3(4):399-403
10725931
Brain Cogn. 2002 Aug;49(3):277-96
12139955
J Exp Psychol Gen. 2004 Sep;133(3):339-54
15355143
Cereb Cortex. 2007 Sep;17 Suppl 1:i125-35
17725995
Neuroimage. 2003 Oct;20(2):1052-63
14568475
Science. 1995 Jul 14;269(5221):218-21
7618082
Hum Brain Mapp. 1999;8(2-3):109-14
10524601
Trends Neurosci. 2002 Jun;25(6):295-301
12086747
Dev Neurosci. 2010 Aug;32(3):249-56
20693803
Cereb Cortex. 2004 Apr;14(4):364-75
15028641
Prog Brain Res. 2001;134:459-70
11702561
Dialogues Clin Neurosci. 2001 Sep;3(3):151-65
22034448
Psychol Aging. 2002 Mar;17(1):85-100
11931290
Neuroimage. 2007 Feb 1;34(3):1238-44
17134916
J Cogn Neurosci. 2000 Nov;12(6):988-1000
11177419
Neuroimage. 2004 Oct;23(2):752-63
15488425
Nature. 1999 Jul 29;400(6743):418-9
10440369
Behav Brain Res. 2009 Jan 30;197(1):186-97
18804123
J Neurosci. 2005 Sep 21;25(38):8680-5
16177036
Cereb Cortex. 2008 May;18(5):1201-9
17925295
Neuropsychologia. 2001;39(12):1263-76
11566310
Neuroscience. 2003;117(4):1037-46
12654355
Neuron. 2002 Feb 28;33(5):827-40
11879658
J Neurosci. 2003 May 15;23(10):3990-8
12764083
Brain. 2000 Feb;123 ( Pt 2):291-307
10648437
Ann N Y Acad Sci. 2007 Feb;1097:171-4
17413020
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9833-8
15210967
Annu Rev Psychol. 2009;60:173-96
19035823
Psychol Sci Public Interest. 2008 Oct;9(1):1-65
26162004
J Cogn Neurosci. 2005 Jan;17(1):84-96
15701241
J Cogn Neurosci. 2000 Jan;12(1):174-87
10769314