The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African Americans.
Populations of African ancestry continue to account for a disproportionate burden of the human immunodeficiency virus type 1 (HIV-1) epidemic in the United States. We investigated the effects of human leukocyte antigen (HLA) class I markers in association with virologic and immunologic control of HIV-1 infection among 338 HIV-1 subtype B-infected African Americans in 2 cohorts: Reaching for Excellence in Adolescent Care and Health (REACH) and HIV Epidemiology Research Study (HERS). One-year treatment-free interval measurements of HIV-1 RNA viral loads and CD4(+) T cells were examined both separately and combined to represent 3 categories of HIV-1 disease control (76 controllers, 169 intermediates, and 93 noncontrollers). Certain previously or newly implicated HLA class I alleles (A*32, A*36, A*74, B*14, B*1510, B*3501, B*45, B*53, B*57, Cw*04, Cw*08, Cw*12, and Cw*18) were associated with 1 or more of the endpoints in univariate analyses. After multivariable adjustments for other genetic and nongenetic risk factors of HIV-1 progression, the subset of alleles more strongly or consistently associated with HIV-1 disease control included A*32, A*74, B*14, B*45, B*53, B*57, and Cw*08. Carriage of infrequent HLA-B but not HLA-A alleles was associated with more favorable disease outcomes. Certain HLA class I associations with control of HIV-1 infection cross the boundaries of race and viral subtype, whereas others appear confined within one or the other of those boundaries.
University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
Aleksandr
A
Lazaryan
Wei
W
Song
Elena
E
Lobashevsky
Jianming
J
Tang
Sadeep
S
Shrestha
Kui
K
Zhang
Janet M
JM
McNicholl
Lytt I
LI
Gardner
Craig M
CM
Wilson
Robert S
RS
Klein
Anne
A
Rompalo
Kenneth
K
Mayer
Jack
J
Sobel
Richard A
RA
Kaslow
D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D018791:CD4 Lymphocyte Count; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D056726:Genetic Association Studies; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1 / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D019562:Viral Load / Q000235:genetics; D055815:Young Adult
D015395:Histocompatibility Antigens Class I
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