Phenylpropanoids from the leaves of Acanthopanax koreanum and their antioxidant activity.
By various chromatographic methods, one new phenylpropanoid, acanthopanic acid (1), and three known compounds, 1,2-O-dicaffeoylcyclopenta-3-ol (2), (4S)-α-terpineol 8-O-β-D-glucopyranoside (3), and rutin (4), were isolated from the methanol extract of the Acanthopanax koreanum leaves. Their structures were elucidated on the basis of spectroscopic analyses, and their antioxidant activities were evaluated by the intracellular reactive oxygen species (ROS) radical scavenging 2',7'-dichlorofluorescein diacetate assay. Among them, compounds 1, 2, and 4 showed significant scavenging capacity with IC(50) values of 3.8, 2.6, and 2.9 μM, respectively, and compound 3 showed weak scavenging capacity with the inhibition rate of 37% at 40 μM.
College of Pharmacy, Chungnam National University, Daejeon, Korea.
Nguyen Xuan
NX
Nhiem
Ki Cheon
KC
Kim
Areum-Daseul
AD
Kim
Jin Won
JW
Hyun
Hee Kyoung
HK
Kang
Phan
P
Van Kiem
Chau
C
Van Minh
Vu Kim
VK
Thu
Bui Huu
BH
Tai
Jeong Ah
JA
Kim
Young Ho
YH
Kim
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028001:Eleutherococcus / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007723:Korea; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
D000975:Antioxidants; D006027:Glycosides; D010666:Phenylpropionates; C555949:acanthopanic acid