Reduced maladaptive behavior and improved social function in a child with PDD-NOS treated with progesterone.
This case report presents the use of progesterone for the regulation of an atypical menstrual cycle in a girl, aged 11 years, who is also diagnosed with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS). The progesterone injections alleviated the prolonged, heavy monthly blood flow, but also caused significant improvements in the patient's mood, behavior, and cognition within four weeks following the initial injections. The use of hormonal treatments, such as progesterone, to effect mood, behavior, and cognition should be further researched to determine other potential therapeutic uses.
Statesboro Psychiatric Associates, GA 30458, USA. fowobi@ymail.com
Olufowobi S
OS
Gbadebo
D000223:Adaptation, Psychological / Q000187:drug effects*; D002659:Child Development Disorders, Pervasive / Q000188:drug therapy* / Q000523:psychology; D002675:Child, Preschool; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D011374:Progesterone / Q000627:therapeutic use*; D011372:Progestins / Q000627:therapeutic use*
D011372:Progestins; D011374:Progesterone
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4389-94
20160081
Neurotherapeutics. 2010 Jul;7(3):250-7
20643377
J Clin Psychiatry. 2005;66 Suppl 10:9-18
16401145
Psychoneuroendocrinology. 2009 Sep;34(8):1121-32
19272715
Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S48-58
19758761
J Affect Disord. 2011 Apr;130(1-2):1-9
20584551
Prog Neurobiol. 2009 Oct;89(2):134-52
19595736