Low thrombogenicity coating of nonwoven PET fiber structures for vascular grafts.
Vascular PET grafts (Dacron) have shown good performance in large vessels (≥ 6 mm) applications. To address the urgent unmet need for small-diameter (2-6 mm) vascular grafts, proprietary high-compliance nonwoven PET fiber structures were modified with various PEG concentrations using PVA as a cross-linking agent, to fabricate non-thrombogenic mechanically compliant vascular grafts. The blood compatibility assays measured through platelet adhesion (SEM and mepacrine dye) and platelet activation (morphological changes, P-selectin secretion, and TXB2 production) demonstrate that functionalization using a 10% PEG solution was sufficient to significantly reduce platelet adhesion/activation close to optimal literature-reported levels observed on carbon-coated ePTFE.
Industrial Materials Institute, National Research Council Canada, 75 de Mortagne, Boucherville, QC J4B6Y4, Canada.
Sashka
S
Dimitrievska
Marion
M
Maire
Gerardo A
GA
Diaz-Quijada
Lucie
L
Robitaille
Abdellah
A
Ajji
L'hocine
L
Yahia
Maria
M
Moreno
Yahye
Y
Merhi
Martin N
MN
Bureau
D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D006801:Humans; D008422:Materials Testing / Q000379:methods; D019007:P-Selectin / Q000378:metabolism; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000737:chemistry*; D011093:Polyethylene Terephthalates / Q000737:chemistry*; D013929:Thromboxane B2 / Q000378:metabolism
D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D019007:P-Selectin; D011093:Polyethylene Terephthalates; D011092:Polyethylene Glycols; D013929:Thromboxane B2