Short term effect and safety of antidiuretic hormone in the patients with nocturia.
OBJECTIVE
To investigate the short-term safety of antidiuretic hormone in elderly patients with nocturnal polyuria, focus on hyponatremia and others electrolytes disturbances and to assess short-term effects on nocturnal urine output and number of nocturnal voids.


METHODS
Between June 2005 and August 2006, a total of 34 patients with nocturnal polyuria were orally administered 0.2 mg desmopressin tablet at bedtime for two weeks. Serum sodium, others electrolytes, urine sodium and urine osmolarity were assessed in the third days, one week and two weeks after treatment with desmopressin and compared adult group (<65 years of age) with elderly group (≥65 years of age). We assessed the effect of desmopressin using a frequency-volume charts and analysed.


RESULTS
In total 34 patients (20 adult, 14 elderly) were analyzed. Desmopressin treatment did not significantly change serum and urine electrolytes include soduim concentration in elderly patients comparied with adult patients. Serum sodium concentration below normal range was recorded in 2 patients in elderly group, but no serious adverse events occurred and recovered without sequelae. The mean number of nocturnal voids decresed (54% reduction) and nocturnal urine output decreased (57% reduction) after using desmopressin.


CONCLUSIONS
Desmopressin was well tolerated and effective in elderly patients with nocturnal polyuria without clinically significant hyponatremia.
Department of Urology, Pusan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Dong Il
DI
Kang
Hak Min
HM
Kim
Seung Yeob
SY
Oh
Jang Ho
JH
Yoon
Hyun Min
HM
Kim
Kweon Sik
KS
Min
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