Influence of fastigial nucleus stimulation on heart rate variability of surgically induced myocardial infarction rats: fastigial nucleus stimulation and autonomous nerve activity.
Electrical stimulation of the rostal cerebellar fastigial nucleus (FNS) has been proved to have neuroprotective effects, but it is not known whether FNS also has a cardioprotective effect. One hundred Sprague-Dawley rats were randomly allocated into four groups, including a sham-operation group (Sham group), rats whose coronary arteries were ligated but the FNs were sham stimulated (AMI group), rats in which both coronary arteries were ligated and FNs were stimulated (FNS group), and rats whose fastigial nuclei were lesioned 5 days before ligation, then their coronary arteries were ligated and FNs were stimulated (FNL group). Heart rate variability parameters were monitored 6 h, 24 h, 7 days and 21 days after ligation, and mortality rates, hemodynamic parameters and infarction sizes were compared after 21 days. FNS improved the survival of rats, and this may be due to the increased vagal and decreased sympathetic tone. FN stimulation does not affect infarction size and hemodynamic parameters. FN stimulation may have a protective effect on surgically induced myocardial infarction rats.
Cardiovascular Department, Armed Police Hospital of Xinjiang, No. 669 South Nanchang Road, 830091, Urumqi, China. almjtj@gmail.com
Alimujiang
A
Abulaiti
Dayi
D
Hu
Danian
D
Zhu
Runfeng
R
Zhang
D000818:Animals; D001341:Autonomic Nervous System / Q000378:metabolism / Q000503:physiopathology*; D002529:Cerebellar Nuclei / Q000503:physiopathology*; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D009638:Norepinephrine
J Electrocardiol. 1988;21 Suppl:S46-55
3063772
J Physiol. 1987 Nov;392:475-91
3446788
Ann N Y Acad Sci. 1997 Dec 19;835:168-86
9616772
Circulation. 1994 Jul;90(1):108-13
8025984
Circ Res. 1985 Jul;57(1):84-95
3891127
Anat Embryol (Berl). 1985;172(3):375-82
4061875
J Physiol. 1970 Oct;210(3):637-50
5499816
J Am Coll Cardiol. 2003 Nov 19;42(10):1767-76
14642686
Am J Cardiol. 1994 Aug 15;74(4):340-5
8059695
Circulation. 2000 Sep 12;102(11):1239-44
10982537
Science. 1976 Oct 8;194(4261):199-200
959848
Histol Histopathol. 1994 Jul;9(3):603-14
7981506
Heart Vessels. 2008 Jan;23(1):53-9
18273547
Am J Physiol. 1982 Jul;243(1):R25-33
7091392
Neurosci Lett. 1996 May 10;209(2):101-4
8761992
Arch Ital Biol. 1985 May;123(2):133-9
4026525
J Neurosci. 1999 May 15;19(10):4142-54
10234042
Brain Res. 1997 Jun 20;760(1-2):272-6
9237546
J Cereb Blood Flow Metab. 1993 Nov;13(6):1020-4
8408310
J Hypertens Suppl. 1984 Dec;2(3):S49-51
6443712
J Physiol. 1987 Dec;393:107-21
3446792
Am J Cardiol. 1999 Nov 15;84(10):1164-9
10569324