Multiscale fabrication of a transparent circulation type blood vessel simulator.
We proposed and fabricated multiscale transparent arteriole and capillary vessel models with circular cross sections of 10-500 μm using photolithography. The circularities of the fabricated 10, 50, and 500 μm diameter microchannels were 84.0%, 61.5%, and 82.3%, respectively. Next, we connected these different models to realize a circulation type blood vessel model simulating arteriole networks. We proposed a novel connection method using an intermediate connector made of wax, which we used to connect these models to make a circulation model. In flow experiments, the fabricated models showed no leakage and circulation models with seamless connections were achieved.
Takuma
T
Nakano
Taro
T
Itoyama
Keisuke
K
Yoshida
Yu
Y
Sawada
Seiichi
S
Ikeda
Toshio
T
Fukuda
Takehisa
T
Matsuda
Makoto
M
Negoro
Fumihito
F
Arai
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