Constituents of cultivated Agaricus blazei.
Two phenylhexane derivatives (1, 2), benzoylergostane (3), N-benzoyl-L-leucine methyl ester (4), two known ergostanes, and highly degraded incisterol were isolated from fruit bodies of Agaricus blazei. Compound 3 exhibited strong cytotoxicity toward HepG2 cells (IC(50) = 6.0 ± 0.33 μM).
Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Yumi
Y
Ueguchi
Katsuyoshi
K
Matsunami
Hideaki
H
Otsuka
Kazunari
K
Kondo
D000364:Agaricus / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004875:Ergosterol / Q000031:analogs & derivatives / Q000737:chemistry; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D000970:Antineoplastic Agents; C015190:ergostane; D004875:Ergosterol
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