Functional specialization of ribosomes?
Ribosomes are highly conserved macromolecular machines that are responsible for protein synthesis in all living organisms. Work published in the past year has shown that changes to the ribosome core can affect the mechanism of translation initiation that is favored in the cell, which potentially leads to specific changes in the relative efficiencies with which different proteins are made. Here, I examine recent data from expression and proteomic studies that suggest that cells make slightly different ribosomes under different growth conditions, and discuss genetic evidence that such differences are functional. In particular, I argue that eukaryotic cells probably produce ribosomes that lack one or more core ribosomal proteins (RPs) under some conditions, and that core RPs contribute differentially to translation of distinct subpopulations of mRNAs.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. wgilbert@mit.edu
Wendy V
WV
Gilbert
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D012269:Ribosomal Proteins
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