Cortical thickness correlates of specific cognitive performance accounted for by the general factor of intelligence in healthy children aged 6 to 18.
Prevailing psychometric theories of intelligence posit that individual differences in cognitive performance are attributable to three main sources of variance: the general factor of intelligence (g), cognitive ability domains, and specific test requirements and idiosyncrasies. Cortical thickness has been previously associated with g. In the present study, we systematically analyzed associations between cortical thickness and cognitive performance with and without adjusting for the effects of g in a representative sample of children and adolescents (N=207, Mean age=11.8; SD=3.5; Range=6 to 18.3 years). Seven cognitive tests were included in a measurement model that identified three first-order factors (representing cognitive ability domains) and one second-order factor representing g. Residuals of the cognitive ability domain scores were computed to represent g-independent variance for the three domains and seven tests. Cognitive domain and individual test scores as well as residualized scores were regressed against cortical thickness, adjusting for age, gender and a proxy measure of brain volume. g and cognitive domain scores were positively correlated with cortical thickness in very similar areas across the brain. Adjusting for the effects of g eliminated associations of domain and test scores with cortical thickness. Within a psychometric framework, cortical thickness correlates of cognitive performance on complex tasks are well captured by g in this demographically representative sample.
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada. sherif.karama@mail.mcgill.ca
Sherif
S
Karama
Roberto
R
Colom
Wendy
W
Johnson
Ian J
IJ
Deary
Richard
R
Haier
Deborah P
DP
Waber
Claude
C
Lepage
Hooman
H
Ganjavi
Rex
R
Jung
Alan C
AC
Evans
D000293:Adolescent; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D002648:Child; D003071:Cognition / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D013647:Task Performance and Analysis
Intelligence. 2009 Mar;37(2):145-155
20161325
Nature. 2004 Jan 22;427(6972):311-2
14737157
Hum Brain Mapp. 2005 Oct;26(2):139-47
15858815
Neuroimage. 2006 Mar;30(1):184-202
16376577
BMC Res Notes. 2010 Jul 22;3:206
20649948
Brain. 2006 Feb;129(Pt 2):386-98
16339797
Neuroimage. 2010 Oct 1;52(4):1667-76
20580844
Neuroimage. 2005 Jul 1;26(3):965-72
15955507
Neuroimage. 2000 Sep;12(3):340-56
10944416
Cereb Cortex. 2007 Oct;17(10):2407-19
17204824
Neuroimage. 2005 Jan 1;24(1):163-73
15588607
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4705-9
20176936
J Neurosci. 2008 Jul 9;28(28):7031-5
18614670
Neuroimage. 2002 Apr;15(4):870-8
11906227
PLoS One. 2008 Jul 23;3(7):e2669
18648501
Neuroimage. 2007 Feb 15;34(4):1535-44
17188895
Psychol Rev. 1990 Jul;97(3):404-31
2381998
Neuroimage. 2007 Oct 1;37(4):1457-64
17689267
BMC Res Notes. 2009 Sep 01;2:174
19723307
Neuroimage. 2008 Jul 1;41(3):1168-76
18434203
Cogn Neuropsychol. 2007 Dec;24(8):867-78
18161499
PLoS One. 2010 Aug 03;5(8):e11934
20689807
Neuroimage. 2005 Aug 1;27(1):210-21
15896981
Nature. 2006 Mar 30;440(7084):676-9
16572172
Diabetes. 2009 May;58(5):1192-200
19208909
Behav Brain Sci. 2007 Apr;30(2):135-54; discussion 154-87
17655784
Neuroimage. 2007 Feb 1;34(3):939-48
17166743
Intelligence. 2009 Mar 1;37(2):156-163
20160919
J Neurosci. 2009 Jun 10;29(23):7619-24
19515930
Nat Rev Neurosci. 2010 Mar;11(3):201-11
20145623
Neuropsychologia. 1971 Mar;9(1):97-113
5146491
Neuroimage. 2011 Feb 1;54(3):1823-30
20932920
PLoS Comput Biol. 2009 May;5(5):e1000395
19492086
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W90-5
20435672
J Int Neuropsychol Soc. 2007 Sep;13(5):729-46
17511896
Am J Psychiatry. 1993 Jan;150(1):130-4
8417555
J Learn Disabil. 2000 May-Jun;33(3):223-38
15505962
Neurology. 2003 Dec 23;61(12):1673-9
14694028
Nat Rev Neurosci. 2004 Jun;5(6):471-82
15152197
Neuroimage. 2004;23 Suppl 1:S189-95
15501088