Methods and design of the baseline survey of the neurological disorders in Salamanca (NEDISA) cohort: a population-based study in Central-Western Spain.
BACKGROUND
To describe the design of the baseline assessment of an epidemiological study of elderly persons living in Salamanca, central-western Spain: the Neurological Diseases in Salamanca (NEDISA) study. We assessed the epidemiology of stroke, cognitive disorders, essential tremor (ET), Parkinson's disease (PD) and restless legs syndrome.


METHODS
In phase 1 (February 1 to May 31, 2007), 4 neurologists and 2 trained general physicians examined and performed phlebotomy on all participants. In phase 2 (June 1, 2007, to June 1, 2008), the participants were reexamined and had a complete neuropsychological assessment. Neuroimaging was performed in participants with cognitive disorders, ET and PD.


RESULTS
The registered study population consisted of 1,077 individuals, but 45 people were ineligible (address change, refusals or death), leaving a final sample of 1,032 (95.8%). The main demographic data on the 1,032 participants (408 men, 624 women) are provided.


CONCLUSIONS
Most of the registered study population was enrolled, and this may have been due to the close relationship between NEDISA researchers and the general physicians in the area of study. The NEDISA study will likely improve our knowledge of prevalence rates of the neurological diseases chosen for study as well as the set of risk factors that predispose individuals in Spain to these disorders.
Department of Neurology, Salamanca University Hospital, Salamanca, Spain.
Jesús
J
Cacho
Julián
J
Benito-León
Elan D
ED
Louis
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000453:epidemiology*; D009483:Neuropsychological Tests; D015995:Prevalence; D012107:Research Design; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
J Alzheimers Dis. 2010;22(3):889-96
20858951
Int Psychogeriatr. 1997;9 Suppl 1:155-62
9447438
Neurology. 2007 Nov 20;69(21):1982-9
18025392
Mov Disord. 2007 Aug 15;22(11):1573-80
17516478
Neuroepidemiology. 2001 May;20(2):125-8
11359080
Mov Disord. 2002 Mar;17(2):242-9
11921108
Neurology. 1994 Dec;44(12):2308-14
7991117
Neurology. 1984 Jul;34(7):939-44
6610841
Mov Disord. 2008 Jan 30;23(2):246-52
17999431
Neurology. 1994 Jan;44(1):61-4
8290093
Ann Neurol. 2001 Jun;49(6):761-9
11409428
Rev Neurol. 2008 Apr 1-15;46(7):416-23
18389461
Neuroepidemiology. 2009;33(3):286-92
19696520
Neurology. 2006 Jan 10;66(1):69-74
16401849
J Neurol Neurosurg Psychiatry. 2010 Sep;81(9):997-1001
20547612
Neurology. 2004 Mar 9;62(5):734-41
15007123
Neuroepidemiology. 2008;30(4):247-53
18515974
J Psychiatr Res. 1975 Nov;12(3):189-98
1202204
Dement Geriatr Cogn Disord. 2002;13(1):13-20
11731710
Neuroepidemiology. 1995;14(4):155-64
7643949
Neurology. 2008 May 6;70(19):1682-7
18458228
Neurology. 2006 May 23;66(10):1500-5
16717208
Neurology. 2005 May 24;64(10):1721-5
15911798
Neuroepidemiology. 2007;29(3-4):213-7
18073494
Sleep Med. 2003 Mar;4(2):101-19
14592341
J Clin Epidemiol. 2010 Feb;63(2):215-22
19473811
J Neurol Neurosurg Psychiatry. 1993 Sep;56(9):973-6
8410037
Lancet. 1974 Jul 27;2(7874):207-10
4135618
Alzheimer Dis Assoc Disord. 2001 Apr-Jun;15(2):89-95
11391090
J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):423-5
19289477
Nat Clin Pract Neurol. 2006 Dec;2(12):666-78; quiz 2p following 691
17117170
J Neurol Sci. 2010 Nov 15;298(1-2):85-90
20817180
Eur J Neurol. 2010 Oct;17(10):1291-7
20561042
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
1564476
Public Health. 2004 Sep;118(6):426-33
15313596
Mov Disord. 2003 Apr;18(4):389-94
12671944
J Psychiatr Res. 1982-1983;17(1):37-49
7183759
Int Psychogeriatr. 1997;9 Suppl 1:65-9
9447429
J Neurol Neurosurg Psychiatry. 2009 May;80(5):494-7
19359288
Neurology. 2004 Oct 12;63(7):1240-4
15477545
Neuroepidemiology. 1996 Jan-Feb;15(1):33-41
8719047
Rev Neurol. 2000 Jun 1-15;30(11):1026-32
10904947
Arch Gen Psychiatry. 1995 Jun;52(6):497-506
7771920
Mov Disord. 2008 Jul 30;23(10):1435-40
18512746
Eur J Neurol. 2009 Mar;16(3):330-6
19170745
Mov Disord. 2003 Mar;18(3):267-74
12621629
J S C Med Assoc. 2004 Feb;100(2):32-8
15040232
Neuroepidemiology. 1994;13(1-2):34-9
8190204
Eur Neurol. 2005;53(3):140-5
15900096
Neuropsychologia. 2001;39(11):1150-7
11527552