Alpha- and beta-synucleins are new diagnostic tools for acute erythroid leukemia and acute megakaryoblastic leukemia.
α-Synuclein is a key component of the Lewy body, a large globular protein complex that forms in the nervous system of patients with Parkinson disease and other dementias [1-3]. Since α-synuclein also occurs in megakaryocytic and erythroid lineages [4-7], we wondered what role synucleins had in the hematopoietic system. Therefore, we studied the expression of α-, β-, and γ-synucleins in a comprehensive panel of patient bone marrows and leukemic cell lines. We observed under expression of α-synuclein in the megakaryocytes of myeloproliferative neoplasm (MPN), but not normal reactive marrow (NRM) or myelodysplastic syndrome (MDS). Conversely, we observed over expression of β-synuclein in the blasts of megakaryoblastic leukemias (MegL), but not acute myeloid leukemia (AML) or erythroleukemia (EryL), suggesting that α- and β-synucleins could be useful adjunct markers for the early detection of MDS and the differential diagnosis of EryL and MegL from other AMLs.
Montefiore Medical Center /Albert Einstein College of Medicine Bronx, Bronx, New York 10467, USA.
Robert W
RW
Maitta
Lucia R
LR
Wolgast
Qing
Q
Wang
Hailing
H
Zhang
Pritish
P
Bhattacharyya
Jerald Z
JZ
Gong
Jaya
J
Sunkara
Joseph M
JM
Albanese
John G
JG
Pizzolo
Linda A
LA
Cannizzaro
K H
KH
Ramesh
Howard
H
Ratech
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D004915:Leukemia, Erythroblastic, Acute / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D007947:Leukemia, Megakaryoblastic, Acute / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D055015:Megakaryocyte-Erythroid Progenitor Cells / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D051844:alpha-Synuclein / Q000378:metabolism*; D051846:beta-Synuclein / Q000378:metabolism*; D051845:gamma-Synuclein / Q000378:metabolism
D015415:Biomarkers; D009363:Neoplasm Proteins; C497604:SNCA protein, human; C497607:SNCB protein, human; C104249:SNCG protein, human; D051844:alpha-Synuclein; D051846:beta-Synuclein; D051845:gamma-Synuclein