Phospholipid composition of erythrocytes and glutathione redox system in rats during adaptation to cholesterol load.
We studied phospholipid composition of erythrocytes and the state of the glutathione redox system in rats during adaptation to cholesterol load for 180 days. The adaptive response is formed during the period from day 30 to day 90 of cholesterol load and is associated with increased relative content of phosphatidylethanolamine and phosphatidylinositol, activation of glutathione redox system enzymes (glutathione reductase and glutathione peroxidase), and enhanced production of glutathione.
Vladivostok Branch of Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Research Institute of Medical Climatology and Medical Rehabilitation, Vladivostok, Russia. karaman@inbox.ru
Yu K
YK
Karaman
T P
TP
Novgorodtseva
N V
NV
Zhukova
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001774:Blood Chemical Analysis; D002784:Cholesterol / Q000097:blood*; D004912:Erythrocytes / Q000737:chemistry*; D005978:Glutathione / Q000096:biosynthesis*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
D010743:Phospholipids; D002784:Cholesterol; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione