[Effect of carvedilol in the combination with quercetine and tiotriazoline on the nucleus density and RNA concentration in the nucleus of cardiac myocytes of spontaneous hypertensive rats].
It was found out in the previous studies, that rats with spontaneous hypertension (SHR) developed the hypertrophy of myocardium, disorders of osmotic properties of erythrocytes membranes, morphological and ultrastructural changes in the cardiac hystiocytes of animals. Carvedilol in SHR rats has decreased blood pressure, and normalized physiological, biochemical and morphological indexes in the cardiac muscle. More expressed effect was observed during the use of carvedilol with metabolic medications--Quercetine and Tiotriazoline. Studies on SHR rats has shown increase of cardiac hystiocyte nuclei density and decrease in RNA concentration in a cardiac muscle. Carvedilol, Quercetine and Tiotriazoline have normalising effect on investigated parameters. The use of carvedilol with Tiotriazoline have more expressed normalising effect on nuclei density of cardiac hystiocytes, and also on RNA concentration PHK in nuclei of cardiac muscle.
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Zahorodnyĭ
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D000077261:Carvedilol; D002467:Cell Nucleus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D004359:Drug Therapy, Combination; D005260:Female; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D011412:Propanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D002227:Carbazoles; D009025:Morpholines; D011412:Propanolamines; D014230:Triazoles; C435843:morpholinium 3-methyl-1,2,4-triazoline-5-thioacetate; D000077261:Carvedilol; D012313:RNA; D011794:Quercetin