Evidence-based mini-review: Is indium-labeled autologous platelet scanning predictive of response to splenectomy in patients with chronic immune thrombocytopenia?
Clinical scenario: An otherwise healthy 25-year-old woman returns to your office for management of chronic primary immune thrombocytopenia. She was diagnosed 6 months earlier and continues to require prednisone 15 mg daily and periodic infusions of intravenous immunoglobulin to maintain a hemostatic platelet count. You discuss second-line treatment options, including splenectomy. The patient asks if there are any means by which to predict likelihood of response to splenectomy. You have heard about the use of indium-labeled autologous platelet scanning for this purpose and wonder what the evidence shows.
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. adam.cuker@uphs.upenn.edu
Adam
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Cuker
Douglas B
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Cines
D001792:Blood Platelets / Q000000981:diagnostic imaging*; D019317:Evidence-Based Medicine; D006801:Humans; D007205:Indium Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods*; D013156:Splenectomy; D013921:Thrombocytopenia / Q000000981:diagnostic imaging* / Q000601:surgery*
D007205:Indium Radioisotopes