Attenuation of oxidative stress & DNA damage in varicocelectomy: implications in infertility management.
Sperm DNA integrity is of vital importance for foetal development and birth of healthy offspring. Oxidative stress and consequent DNA damage are the major cause of decline in semen quality in men with varicocele. A preliminary study was conducted on 11 men with clinical varicocele who also had high levels of reactive oxygen species (ROS), to assess DNA damage in sperms and ROS levels before and after varicocelectomy. Varicocelectomy resulted in rapid (1 month) significant (P<0.001) decline in free radical levels and slow (3-6 months) significant decline in DNA damage levels. Thus men undergoing varicocelectomy should try concieving only 6 months following surgery.
Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India. rima_dada@rediffmail.com
Rima
R
Dada
Monis Bilal
MB
Shamsi
Sunderarjan
S
Venkatesh
Naramada Prasad
NP
Gupta
Rajeev
R
Kumar
D004249:DNA Damage / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000601:surgery* / Q000628:therapy; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome; D014646:Varicocele / Q000601:surgery*
D017382:Reactive Oxygen Species
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