Enhanced two-photon singlet oxygen generation by photosensitizer-doped conjugated polymer nanoparticles.
We have prepared photosensitizer-doped conjugated polymer nanoparticles by using a reprecipitation method. The conjugated polymer, poly[9,9-dibromohexylfluorene-2,7-ylenethylene-alt-1,4-(2,5-dimethoxy)phenylene] (PFEMO), was used as the host matrix to disperse tetraphenylporphyrin (TPP). These TPP-doped PFEMO nanoparticles are stable and have a uniform size of ∼50 nm. Efficient intraparticle energy transfer from PFEMO to TPP has been observed. The TPP emission of the nanoparticles was found to be enhanced by 21-fold by PFEMO under two-photon excitation. Enhanced two-photon excitation singlet oxygen generation efficiency in the TPP-doped PFEMO nanoparticles has been demonstrated. Our results suggest that these photosensitizer-doped conjugated polymer nanoparticles can act as novel photosensitizing agents for two-photon photodynamic therapy and related applications.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543.
Xiaoqin
X
Shen
Fang
F
He
Jihong
J
Wu
Guo Qin
GQ
Xu
Shao Q
SQ
Yao
Qing-Hua
QH
Xu
D000042:Absorption; D000480:Alkynes / Q000737:chemistry*; D004735:Energy Transfer; D005449:Fluorenes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000480:Alkynes; D005449:Fluorenes; D017319:Photosensitizing Agents; D011108:Polymers; D011166:Porphyrins; C558512:poly(9,9-dibromohexylfluorene-2,7-ylenethylene-alt-1,4-(2,5-dimethoxy)phenylene); C409084:tetraphenylporphyrin; D014867:Water; D026082:Singlet Oxygen