Flecainide acetate acetic acid solvates.
Flecainide acetate forms acetic acid solvates with 0.5 and 2 acetic acid molecules. Powder X-ray diffraction, differential thermal analysis/thermogravimetric, infrared, and potentiometric titration were used to determine the composition of solvates. Flecainide acetate hemisolvate with acetic acid decomposes to form a new crystalline form of flecainide acetate. This form is less stable than the already known polymorphic form at all temperatures, and it is formed due to kinetic reasons. Both flecainide acetate nonsolvated and flecainide acetate hemisolvate forms crystallize in monoclinic crystals, but flecainide triacetate forms triclinic crystals. Solvate formation was not observed when flecainide base was treated with formic acid, propanoic acid, and butanoic acid. Only nonsolvated flecainide salts were obtained in these experiments.
Faculty of Chemistry, University of Latvia, Riga, Latvia. kaspijs_ve@inbox.lv
Kaspars
K
Veldre
Andris
A
Actiņs
Zane
Z
Eglite
D019342:Acetic Acid / Q000737:chemistry*; D000889:Anti-Arrhythmia Agents / Q000737:chemistry*; D003460:Crystallization; D005424:Flecainide / Q000737:chemistry*; D011199:Potentiometry; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D000889:Anti-Arrhythmia Agents; D012997:Solvents; D005424:Flecainide; D019342:Acetic Acid