Evaluation of cerebral vasomotor reactivity in Parkinson's disease: is there any association with orthostatic hypotension?
OBJECTIVE
Our aim was to look for a probable relationship between cerebral vasomotor reactivity (VMR) and orthostatic hypotension (OH) in Parkinson's disease (PD).


METHODS
This study was conducted on 44 patients with PD. Assessment of cerebral VMR was performed by means of transcranial Doppler (TCD) of middle cerebral artery (MCA) before and after a vasodilatory stimulus, carbon dioxide test. Moreover, orthostatic hypotension was evaluated.


RESULTS
OH was presented in 12 (27.3%) Parkinson's patients. The average resting blood flow velocity (BFV) in the MCA was 30.20 (SD=9.58)cms(-1) which significantly increased to 46.25 (SD=16.23)cms(-1) after carbon dioxide test (P<0.001). Impaired VMR was observed in 15 (34.1%) of the subjects, while it was not associated with the presence of OH (P=0.770).


CONCLUSIONS
Evaluation of VMR in patients affected by PD, could assist in early diagnosis of cerebral autonomic dysfunction and prevent its serious consequences prior and more valid to OH.
Department of Neurology, Rasool-e-Akram Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Babak
B
Zamani
Mehrnoush
M
Mehrabani
Seyed-Mohammad
SM
Fereshtehnejad
Mohammad
M
Rohani
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed; D017585:Ultrasonography, Doppler, Transcranial; D014664:Vasodilation / Q000502:physiology*
D000978:Antiparkinson Agents; D002245:Carbon Dioxide; D007980:Levodopa