Antinociceptive effects of intracerebroventricular injection of the galanin receptor 1 agonist M 617 in rats.
Previous studies in our laboratory demonstrated that galanin and its receptors play important roles in nociceptive modulation in the central nervous system. The present study was performed to explore the antinociceptive effects of the galanin receptor 1 agonist M 617 in the central nervous system of rats. Intracerebroventricular injection of 0.1nmol, 0.5nmol, 1nmol or 2nmol of M 617 induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats. Furthermore, both intracerebroventricular injection of M 617 and galanin induced significant increases in HWLs in rats. Interestingly, there were no significant differences between the antinociceptive effects induced by M 617 and galanin, indicating that galanin receptor 1 plays main roles in galanin-induced antinociceptive effects in the brain of rats.
Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane, Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.
Li-Bo
LB
Fu
Xue-Bin
XB
Wang
Shi
S
Jiao
Xia
X
Wu
Long-Chuan
LC
Yu
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019004:Galanin / Q000008:administration & dosage* / Q000031:analogs & derivatives; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage*; D010455:Peptides / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D044091:Receptor, Galanin, Type 1 / Q000819:agonists*
D000700:Analgesics; C000614145:M617 peptide; D010446:Peptide Fragments; D010455:Peptides; D044091:Receptor, Galanin, Type 1; D019004:Galanin; D001920:Bradykinin