Incidence of and risk factors for community acquired pneumonia in US HIV-infected children, 2000-2005.
The incidence of and risk factors for community-acquired pneumonia (CAP) are described from 2000 to 2005 in a multicenter US cohort of HIV-infected children. In 736 patients, 87 episodes of CAP (33.2 events/1000 person-years) had a mean CD4% of 23% (controls: 30%) and mean CD4 cell count of 668 cells/μl (controls: 870 cells/μl). CAP incidence decreased 44% from 2000-2001 to 2002-2005. On multivariate analysis, viral load at least 100 000 copies/ml (odds ratio 3.98; confidence interval 1.05-15.13) was associated with CAP. Herd immunity through pneumococcal immunization may have diluted the effect of individual immunization in this cohort.
Department of Pediatrics, Children's Hospital Philadelphia, Pennsylvania, USA. steenhoff@e-mail.chop.edu
Andrew P
AP
Steenhoff
Joshua S
JS
Josephs
Richard M
RM
Rutstein
Kelly A
KA
Gebo
George K
GK
Siberry
Aditya H
AH
Gaur
Robert
R
Warford
P Todd
PT
Korthuis
Stephen A
SA
Spector
Samir S
SS
Shah
D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011014:Pneumonia / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D012307:Risk Factors; D019562:Viral Load; D055815:Young Adult
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