Exoglycosidase markers of diseases.
Exoglycosidases are hydrolases involved in lysosomal degradation of oligosaccharide chains of glycoconjugates (glycoproteins, glycolipids and proteoglycans). In tissues and body fluids, a higher exoglycosidase specific activity is found in N-acetyl-β-hexosaminidase, than β-glucuronidase, α-L-fucosidase, β-galactosidase, α-mannosidase and α-glucosidase. Determination of exoglycosidases (especially N-acetyl-β-hexosaminidase and β-glucuronidase) in body fluids could be an inexpensive, easy to perform and sensitive test for pathological evaluation, as well as in screening and monitoring many diseases, including alcohol abuse, risk of arteriosclerosis, bacterial infections (e.g. Lyme borreliosis), chronic inflammatory processes, such as rheumatoid arthritis and juvenile idiopathic arthritis, asthma, autoimmune hepatitis and primary biliary cirrhosis, as well as cancers.
Medical Institute, College of Computer Science and Business Administration, 18-400 Łomża, Poland.
Sylwia
S
Chojnowska
Alina
A
Kępka
Sławomir Dariusz
SD
Szajda
Napoleon
N
Waszkiewicz
Marcin
M
Bierć
Krzysztof
K
Zwierz
D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D001826:Body Fluids / Q000201:enzymology; D004194:Disease; D006001:Glycoconjugates / Q000737:chemistry / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006801:Humans; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
D015415:Biomarkers; D006001:Glycoconjugates; D006026:Glycoside Hydrolases; D001619:beta-N-Acetylhexosaminidases