LINGO1 variants in the French-Canadian population.
Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).
CHUM Research Center and the Department of Medicine, Université de Montréal, Montreal, Québec, Canada.
Cynthia V
CV
Bourassa
Jean-Baptiste
JB
Rivière
Patrick A
PA
Dion
Geneviève
G
Bernard
Sabrina
S
Diab
Michel
M
Panisset
Sylvain
S
Chouinard
Nicolas
N
Dupré
Hélène
H
Fournier
John
J
Raelson
Majid
M
Belouchi
Guy A
GA
Rouleau
D002170:Canada / Q000208:ethnology; D016022:Case-Control Studies; D020329:Essential Tremor / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People
C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
Eur J Hum Genet. 2010 Jul;18(7):838-43
20372186
Mov Disord. 2010 Apr 30;25(6):717-23
20310002
Neurogenetics. 2010 Oct;11(4):401-8
20369371
Nat Genet. 2009 Mar;41(3):277-9
19182806
Brain. 2007 Jun;130(Pt 6):1456-64
17353225
Parkinsonism Relat Disord. 2010 Feb;16(2):109-11
19720553
Am J Hum Genet. 2007 Mar;80(3):531-8
17273975
N Engl J Med. 2001 Sep 20;345(12):887-91
11565522
Neurosci Lett. 2010 Sep 6;481(2):69-72
20600614
Bioinformatics. 2003 Jan;19(1):149-50
12499305
Am J Hum Genet. 2007 Sep;81(3):559-75
17701901
Neurology. 2009 Oct 6;73(14):1161-2
19805735
PLoS Biol. 2010 Jan 26;8(1):e1000294
20126254