Esophageal impedance monitoring for gastroesophageal reflux.
Dual pH-multichannel intraluminal impedance (pH-MII) is a sensitive tool for evaluating overall gastroesophageal reflux disease, and particularly for permitting detection of nonacid reflux events. pH-MII technology is especially useful in the postprandial period or at other times when gastric contents are nonacidic.pH-MII was recently recognized by the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition as being superior to pH monitoring alone for evaluation of the temporal relation between symptoms and gastroesophageal reflux. In children, pH-MII is useful to correlate symptoms with reflux (particularly nonacid reflux), to quantify reflux during tube feedings and the postprandial period, and to assess efficacy of antireflux therapy. This clinical review is simply an evidence-based overview addressing the indications, limitations, and recommended protocol for the clinical use of pH-MII in children.
Department of Pediatric Gastroenterology, Center for Advanced Research in Neuromuscular Gastrointestinal Disorders, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA. hayat.mousa@nationwidechildrens.org
Hayat M
HM
Mousa
Rachel
R
Rosen
Frederick W
FW
Woodley
Marina
M
Orsi
Daneila
D
Armas
Christophe
C
Faure
John
J
Fortunato
Judith
J
O'connor
Beth
B
Skaggs
Samuel
S
Nurko
D002648:Child; D017097:Electric Impedance; D050782:Esophageal pH Monitoring; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012680:Sensitivity and Specificity
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