Nonlinear PD2i heart rate complexity algorithm detects autonomic neuropathy in patients with type 1 diabetes mellitus.
OBJECTIVE
The aim of this study was to test whether a new heart rate variability (HRV) complexity measure, the Point Correlation Dimension (PD2i), provides diagnostic information regarding early subclinical autonomic dysfunction in diabetes mellitus (DM). We tested the ability of PD2i to detect diabetic autonomic neuropathy (DAN) in asymptomatic young DM patients without overt neuropathy and compared them to age- and gender-matched controls.


METHODS
HRV in DM type 1 patients (n=17, 10 female, 7 male) aged 12.9-31.5 years (duration of DM 12.4±1.2 years) was compared to that in a control group of 17 healthy matched probands. The R-R intervals were measured over 1h using a telemetric ECG system.


RESULTS
PD2i was able to detect ANS dysfunction with p=0.0006, similar to the best discriminating MSE scale, with p=0.0002.


CONCLUSIONS
The performance of PD2i to detect DAN in asymptomatic DM patients is similar to the best discriminative power of previously published complexity measures.


CONCLUSIONS
The PD2i algorithm may prove to be an easy to perform and clinically useful tool for the early detection of autonomic neuropathy in DM type 1 patients, especially given its minimal data requirements.
Vicor Technologies, Inc., Boca Raton, FL, USA.
James E
JE
Skinner
Daniel N
DN
Weiss
Jerry M
JM
Anchin
Zuzana
Z
Turianikova
Ingrid
I
Tonhajzerova
Jana
J
Javorkova
Kamil
K
Javorka
Mathias
M
Baumert
Michal
M
Javorka
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D002648:Child; D003627:Data Interpretation, Statistical; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004562:Electrocardiography; D019277:Entropy; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D017711:Nonlinear Dynamics; D055815:Young Adult