Evaluation of effect of triterpenes and limonoids on cell growth, cell cycle and apoptosis in human tumor cell line.
Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.
Universidade Federal de São Carlos, Laboratório de Produtos Naturais, Departamento de Química, São Carlos, SP, Brazil.
Cristiane M
CM
Cazal
Kantima
K
Choosang
Vanessa Gisele P
VG
Severino
Marcio S
MS
Soares
Andre Lucio F
AL
Sarria
Joao B
JB
Fernandes
Maria Fatima G F
MF
Silva
Paulo Cezar
PC
Vieira
Pannee
P
Pakkong
Gabriela M
GM
Almeida
M Helena
MH
Vasconcelos
Maria S J
MS
Nascimento
Madalena M M
MM
Pinto
D000230:Adenocarcinoma / Q000188:drug therapy; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D029582:Meliaceae / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D036701:Limonins; D014315:Triterpenes