Update on morphea: part II. Outcome measures and treatment.
Morphea is a rare fibrosing disorder of the skin and underlying tissues. The underlying pathogenesis of morphea is not completely understood at this time, but ultimately results in an imbalance of collagen production and destruction. Evidence-based treatment options of morphea are limited secondary to the rarity of the disease, and the lack of universally used validated outcome measures. The most commonly used outcome measures are skin scores, computerized surface area measurement, durometer, cutometer, thermography, and ultrasound measurements. The Localized Scleroderma Cutaneous Assessment Tool is a promising recently validated skin scoring tool that allows differentiation between activity and damage, is sensitive to change, and requires no additional equipment. The most robust data in the treatment of morphea exists for methotrexate in combination with systemic steroids and ultraviolet A1.
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Nicole.Fett@uphs.upenn.edu
Nicole
N
Fett
Victoria P
VP
Werth
D000293:Adolescent; D000328:Adult; D002648:Child; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D012867:Skin / Q000473:pathology; D013256:Steroids / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use; D013817:Thermography; D016896:Treatment Outcome; D014463:Ultrasonography; D014467:Ultraviolet Therapy; D054928:Validation Studies as Topic
D013256:Steroids; D009173:Mycophenolic Acid; D016559:Tacrolimus; D008727:Methotrexate
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