New insights into the inactivation of gastric tumor suppressor RUNX3: the role of H. pylori infection.
Runt-related transcription factor 3, or RUNX3, is a tumor suppressor in gastric cancer. Inactivation of RUNX3 is causally associated with the genesis of gastric cancer, since RUNX3 is frequently inactivated in gastric cancers by hemizygous deletion, hypermethylation of its promoter, or protein mislocalization. Infection with Helicobacter pylori is the strongest risk factor for the development of gastric cancer. Recent studies have indicated that H. pylori infection plays an important role in the inactivation of RUNX3, and that this inactivation contributes to the pathogenesis of H. pylori. Here we summarize these recent advances and discuss their significances in understanding the initiation and development of gastric cancer.
Department of Biochemistry, College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Ying-Hung Nicole
YH
Tsang
Acacia
A
Lamb
Lin-Feng
LF
Chen
D000818:Animals; D050677:Core Binding Factor Alpha 3 Subunit / Q000378:metabolism*; D016481:Helicobacter Infections / Q000382:microbiology / Q000503:physiopathology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000382:microbiology
D050677:Core Binding Factor Alpha 3 Subunit
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