Tubulointerstitial nephritis and uveitis syndrome (TINU) with Fanconi's syndrome.
We report a 57-year-old woman with concurrent tubulointerstitial nephritis and uveitis syndrome (TINU) and Fanconi's syndrome. She presented with sudden onset of bilateral ocular pain, blurred vision, acute renal failure, glucosuria and proteinuria. Slit lamp examination revealed acute bilateral anterior uveitis. Tubulointerstitial nephritis was confirmed by kidney biopsy. Laboratory examination revealed normoglycemic glucosuria, proteinuria, normal anion-gap metabolic acidosis, phosphaturia, urinary uric acid wasting and kaliuresis leading to hypokalemia. Her vision and renal function improved gradually after systemic steroid therapy. There have been rare reports of TINU syndrome which had features of Fanconi's syndrome. The prevalence of TINU syndrome may be underestimated, and its association with Fanconi's syndrome requires further investigation.
Division of Nephrology, Department of Medicine, , National Yang-Ming University, Taipei, Taiwan.
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YH
Yao
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CC
Lin
Y-M
YM
Chung
A-H
AH
Yang
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Li
C-C
CC
Lin
Y-P
YP
Lin
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WC
Yang
C-Y
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Yang
D001706:Biopsy; D003941:Diagnostic Techniques, Ophthalmological; D005198:Fanconi Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D020127:Recovery of Function; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D014605:Uveitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D014785:Vision, Ocular
D013256:Steroids