[Pharmacological correction of Th1 and Th2 lymphocyte activity and cytokine profile in ethanol intoxicated rats].
It was established in experiments on noninbred rats that their ethanol intoxication (13 days; total dose, 2.6 LD50) significantly reduces the concentration of blood cytokines IFNgamma, IL-2, IL-4, IL-10, increases the concentration of IL-6, suppresses the immune responses, and reduces the interrelation IFNgamma/IL-4 in comparison to the control, which testifies to the greater damage of Th1 cells in comparison to Th2 lymphocytes. The immunomodulator polyoxidonium administered for four days at a daily dose of 700 microg/kg fully restores the cellular and humoral immune responses and the synthesis of cytokines IFNgamma, IL-2, and IL-4 and partly restores the production of IL-10.
P F
PF
Zabrodskiĭ
A A
AA
Svistunov
V G
VG
Lim
V A
VA
Grishin
A V
AV
Kuz'min
A V
AV
Smurov
D000435:Alcoholic Intoxication / Q000097:blood* / Q000276:immunology; D000818:Animals; D002492:Central Nervous System Depressants / Q000009:adverse effects* / Q000494:pharmacology; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D000431:Ethanol / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism*; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism*
D002492:Central Nervous System Depressants; D016207:Cytokines; D010879:Piperazines; D011108:Polymers; D000431:Ethanol; C540909:azoximer bromide