Effects of 5-HT2A receptor stimulation and blocking on immune response.
Experiments on CBA mice showed that selective stimulation of 2A serotonin receptors with DOI agonist (1 mg/kg) led to suppression of the immune response and reduction of the spleen and peripheral blood CD8(+)T cell counts with the cytotoxic/suppressor function. Selective blockade of these receptors with ketanserin (1 mg/kg) had an opposite effect: immunostimulation with an increase in CD8(+)T cell count in the spleen. These data indicate the involvement of 2A serotonin receptors in immunosuppressive mechanisms of serotoninergic system.
Laboratory of Neurochemical Modulation Mechanisms, Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia.
S M
SM
Davydova
M A
MA
Cheido
M M
MM
Gevorgyan
G V
GV
Idova
D000662:Amphetamines / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects*; D005434:Flow Cytometry; D007108:Immune Tolerance / Q000187:drug effects*; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D044402:Receptor, Serotonin, 5-HT2A / Q000276:immunology* / Q000378:metabolism*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000662:Amphetamines; D044402:Receptor, Serotonin, 5-HT2A; D058826:Serotonin 5-HT2 Receptor Agonists; D012702:Serotonin Antagonists; D007650:Ketanserin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine