[Birth weight and genetic risk of type 2 diabetes in Czech population].
BACKGROUND
Birth weight is associated with type 2 diabetes mellitus and other late-onset metabolic diseases. Reduced birth weight is associated with an increased risk of insulin resistance, type 2 diabetes, and atherosclerosis. Also high birth weight represents risk factor for development of type 2 diabetes later in life. In this study, we investigate whether type 2 diabetes risk-confering alleles and biochemical as well as anthropometrical type 2 diabetes risk markers associate with birth weight in our Czech cohort.


RESULTS
Association between high birth weight and higher BMI in adulthood was found. Low birth weight was associated with higher glycaemia and insulinaemia as well as lower peripheral insulin sensitivity during oGTT. The examination of candidate genes provides evidence that Ngn3 and PPARalpha are involved in final birth weight regulation.


CONCLUSIONS
According to our results, we suggest that birth weight should be an integral part of medical history record.
Oddelení molekulární endokrinologie Endokrinologického ustavu Praha. dvejrazkova@endo.cz
D
D
Vejrazková
M
M
Vanková
P
P
Lukásová
J
J
Vcelák
O
O
Bradnová
S
S
Prazáková
H
H
Kvasnicková
B
B
Bendlová
D001724:Birth Weight; D018153:Czech Republic; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged