Large scale zebrafish-based in vivo small molecule screen.
Given their small embryo size, rapid development, transparency, fecundity, and numerous molecular, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine.
Jijun
J
Hao
Charles H
CH
Williams
Morgan E
ME
Webb
Charles C
CC
Hong
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004625:Embryo, Nonmammalian / Q000187:drug effects; D015027:Zebrafish / Q000196:embryology*
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