[Insect cholinesterases and irreversible inhibitors. Statistical treatment of the data].
The data on sensitivity of cholinesterases (ChE) of different insects to reversible inhibitors, as well as the data on physico-chemical parameters of amino acids constituting their active centers, were treated by factor analysis and juxtaposed. It is shown that both these characteristics are related to taxonomical belonging of insects. It is revealed the "material substrate" of the factors determining inhibitor action specificity, which are specific sites in ChE active center.
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Moralev
D000818:Animals; D020134:Catalytic Domain; D002800:Cholinesterase Inhibitors / Q000737:chemistry*; D002802:Cholinesterases / Q000737:chemistry* / Q000378:metabolism; D019476:Insect Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D007313:Insecta / Q000201:enzymology*
D002800:Cholinesterase Inhibitors; D019476:Insect Proteins; D002802:Cholinesterases