Shedding light on the ghrelin/GOAT metabolism saga.
Getting the GOAT: The identification of a ghrelin O-acyltransferase (GOAT) inhibitor displaying metabolic modulatory activities has recently been reported. This research might provide a link for answering key questions relating to ghrelin's role(s) in obesity and diabetes.
Department of Chemistry, The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Amanda L
AL
Garner
Kim D
KD
Janda
D000217:Acyltransferases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D054439:Ghrelin / Q000737:chemistry*; D006801:Humans; D009765:Obesity / Q000188:drug therapy
D004791:Enzyme Inhibitors; D054439:Ghrelin; D000217:Acyltransferases