Highly enantioselective Pd-catalyzed allylic alkylation of indoles using Sulfur-MOP ligand.
The preparation of various (R)-Sulfur-MOP ligands with aryl and alkyl substituents on sulfur, and the application of these ligands to Pd-catalyzed asymmetric allylic alkylation of indoles is reported. The sulfur substituent served as an effective stereocontrol element, and in the case of the 2-i-PrPh substituent on sulfur, the allylation products from an array of simple and substituted indoles were obtained with high enantioselectivity (up to 95% ee).
Faculty of Engineering, Niigata University, Nishi-ku, Niigata, Japan. hoshi@gs.niigata-u.ac.jp
Takashi
T
Hoshi
Koji
K
Sasaki
Shun
S
Sato
Yuichi
Y
Ishii
Toshio
T
Suzuki
Hisahiro
H
Hagiwara