Irreversible amnesia in rats and edible snails under conditions of associative memory reconsolidation disturbance caused by NMDA-glutamate receptor antagonist.
The effect of MK-801, an antagonist to NMDA-glutamate receptors, on reconsolidation of olfactory discrimination task in rats and taste discrimination in edible snails was examined. Twenty-four hours after conditioning, the animals received a single systemic injection of MK-801 followed by a reminding conditional stimulus. Disturbances in retrieval of the acquired task were observed 10 days after injection followed by a reminding procedure. Repeated conditioning of these animals did not restore the task. Injection of MK-801 without reminding stimulation had no effect on task retention. Thus, disturbances of NMDA-dependent reconsolidation of the associative memory in animals of different taxonomic groups irreversibly eliminated long-term memory.
P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
Z I
ZI
Storozheva
S V
SV
Solntseva
V P
VP
Nikitin
A T
AT
Proshin
V V
VV
Sherstnev
D000647:Amnesia / Q000503:physiopathology*; D000818:Animals; D001244:Association; D003213:Conditioning, Psychological; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D012903:Smell; D012908:Snails; D018709:Statistics, Nonparametric; D013649:Taste
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate