Prophylaxis for infective endocarditis.
Although antibiotic prophylaxis for patients at risk for bacterial endocarditis has never been scientifcally tested, it is now an accepted practice in medicine. Patients at risk include all individuals with prosthetic valves, congenital or rheumatic heart disease, previous endocarditis, idiopathic hypertrophic subaortic stenosis (IHSS), and mitral valve prolapse with a holosytolic murmur. Dental, upper respiratory tract, genitourinary and gastrointestinal procedures associated with bacteremia are reviewed. New antibiotic regimens utilizing oral agents for shorter periods have recently been published and are outlined here. Patients at high risk of endocarditis (especially those with prosthetic valves) should continue to receive prophylactic antibiotics by the parenteral route.
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Gray
Medicine (Baltimore). 1977 Jan;56(1):61-77
834137
Cardiovasc Clin. 1986;16(2):335-57
2943404
Ann Intern Med. 1986 Mar;104(3):419-23
3511827
Am J Med. 1985 Jun 28;78(6B):149-56
4014277
N Engl J Med. 1982 Sep 23;307(13):776-81
7110242
Am J Cardiol. 1986 Feb 15;57(6):478-9
3946265
Lancet. 1986 May 31;1(8492):1267
2872403
JAMA. 1983 Nov 4;250(17):2318-22
6632128
Gut. 1983 Nov;24(11):1078-93
6354885