Neuropsychological status of children with newly diagnosed idiopathic childhood epilepsy.
We characterized the neuropsychological status of children with newly diagnosed idiopathic childhood epilepsy and measured differences in IQ between children with different types of epilepsy. The Korean Education Development Institute-Wechsler Intelligence Scale for Children (KEDI-WISC) was administered to 72 patients (35 males and 37 females), of mean age 8.7±2.6 years, with newly diagnosed idiopathic childhood epilepsy. Of these patients, 22 (30.6%) had generalized epilepsy, 48 (66.7%) localization-related epilepsy, and 2 (2.8%) mixed epilepsy. Children with generalized epilepsy and benign childhood epilepsy with centro-temporal spikes (BCECTS) were of similar verbal IQ and full-scale IQ, although performance IQ was significantly lower in patients with generalized epilepsy. Among children with BCECTS, those with unilateral spikes had higher full-scale and performance IQ scores than those with bilateral spikes. Follow-up studies on large numbers of patients are needed to determine the effects of epilepsy per se, and antiepileptic drugs, on intelligence.
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap-Dong, Sonpa-Gu, Seoul 138-736, Republic of Korea.
Min Hee
MH
Jeong
Mi-Sun
MS
Yum
Tae-Sung
TS
Ko
Su Jeong
SJ
You
Eun Hye
EH
Lee
Hanik K
HK
Yoo
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D003071:Cognition / Q000502:physiology; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D019305:Epilepsy, Rolandic / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D008297:Male; D009483:Neuropsychological Tests
D000927:Anticonvulsants