Signal transduction through G proteins in the cardiac myocyte.
The membrane of the cardiocyte contains a large variety of molecules whose function is to transmit signals from outside the cell to inside. The signals are initiated by receptors for a variety of agonists and propagated by a family of heterotrimeric G proteins to ion channels and intracellular enzymes. The large complement of receptors, G proteins, and effectors found in the cardiocyte raises fundamental questions about the mechanisms that assure the precision and timing of the heart cell's response to external stimuli.
Department of Medicine, Brigham UK; Women's Hospital and Harvard Medical School, Boston, MA 02115 USA.
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Clapham