Interleukin-18 promoter polymorphisms and risk of Parkinson's disease in a Han Chinese population.
The etiology of sporadic Parkinson's disease (PD) is not well established. Interleukin-18 (IL-18), a member of pro-inflammatory cytokines, might influence the risk of sporadic PD occurrence and development. In this study, two DNA polymorphisms at interleukin (IL)-18 promoter, -607C/A (rs1946518) and -137G/C (rs187238), were examined in sporadic PD patients in a Han Chinese population with 290 sporadic PD patients and 200 healthy controls. Direct sequencing was performed in 10% of the samples to validate the genotyping results. The results revealed that for -607C/A polymorphisms, there were significant differences in genotype distribution between PD and control in the total sample (P=0.017) and between LOPD and healthy-matched controls subgroup (P=0.011). For -137G/C polymorphisms, there were no significant differences in genotype distribution and gender and age-related differences between PD and control in the total sample (P=0.610). Results in this study revealed that the IL-18 607C/A polymorphism is a risk factor for sporadic LOPD in Han Chinese population, while IL-18 137G/C polymorphism is not a risk factor for sporadic PD in the Han Chinese population.
Department of Neurology, Affiliated Hospital of Medical College, Qingdao University, Qingdao, PR China.
Xiang
X
Xu
Dequan
D
Li
Qing
Q
He
Jing
J
Gao
Biao
B
Chen
Anmu
A
Xie
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
D020382:Interleukin-18