Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum.
The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC₅₀ values of 46.0 μM and 23.3 μM, respectively.
Department of Biotechnology, Hanbat National University, Dukmyung-dong, Yuseong-gu, Daejeon 305-719, Republic of Korea.
Byoung Wook
BW
Choi
Hyun Sun
HS
Lee
Kyung Bok
KB
Lee
Bong Ho
BH
Lee
D000818:Animals; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D000459:Phaeophyceae / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003374:Coumarins; D004224:Diterpenes; C572850:dictyol E; C575648:hydroxyisocrenulatin; D051048:Diacylglycerol O-Acyltransferase