Synaptic vesicle recycling at the calyx of Held.
Efficient endocytosis is crucial for maintaining synaptic transmission because of its role in retrieving constituent membrane and associated proteins. In the past three decades three modes of endocytosis have been proposed involving the central nervous system: clathrin-mediated endocytosis, kiss-and-run endocytosis and bulk endocytosis. These forms of endocytosis can be induced under different conditions, but their detailed molecular mechanisms and functions are largely unknown. Here, we review the existence and initiation of all three modes of endocytosis at a giant glutamatergic synapse, the calyx of Held. The possibility of direct electrophysiology recording in this synapse allows for accurate tracking of exocytosis and endocytosis via capacitance measurements. Future aims will be focused on identifying the molecules that undergo the different mechanisms of endocytosis and the conditions under which different forms of endocytosis predominate.
Institutes of Brain Science, School of Life Sciences, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.
Lei
L
Xue
Yan-ai
YA
Mei
D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D004705:Endocytosis; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000378:metabolism*
Nat Neurosci. 2009 Aug;12(8):1003-1010
19633667
J Cell Biol. 1973 May;57(2):499-524
4348791
Nat Rev Neurosci. 2002 Jan;3(1):53-64
11823805
Neuron. 2002 Dec 19;36(6):1127-43
12495627
Nat Neurosci. 2000 Dec;3(12):1256-65
11100146
J Neurosci. 2008 May 21;28(21):5403-11
18495874
Annu Rev Physiol. 2002;64:355-405
11826273
J Neurophysiol. 2002 Jan;87(1):15-29
11784726
Neuron. 2004 Sep 30;44(1):5-21
15450156
Neuron. 2001 Apr;30(1):171-82
11343653
J Physiol. 2002 May 1;540(Pt 3):861-73
11986375
J Neurosci. 2003 Aug 6;23(18):7059-68
12904466
Nature. 2007 Nov 29;450(7170):676-82
18046404
Neuron. 2000 Sep;27(3):551-9
11055437
J Physiol. 2010 Dec 15;588(Pt 24):4987-94
21041528
Nature. 2002 May 30;417(6888):555-9
12037569
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10234-9
17551019
Nature. 1994 Feb 24;367(6465):735-9
7906397
J Cell Biol. 1973 May;57(2):315-44
4348786
Nature. 2002 Jul 4;418(6893):89-92
12097912
J Physiol. 2005 Apr 1;564(Pt 1):173-87
15695246
J Neurosci Methods. 2004 Apr 30;134(2):121-31
15003378
J Neurosci. 2005 May 25;25(21):5127-37
15917453
J Physiol. 1974 Jun;239(2):106P-108P
4370287
J Physiol. 1995 Dec 15;489 ( Pt 3):825-40
8788946
Nature. 2009 May 7;459(7243):93-7
19279571
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6712-6
6959149
J Neurosci. 2002 Dec 15;22(24):10567-79
12486149
Nature. 2006 Nov 2;444(7115):102-5
17065984
Nat Neurosci. 1998 Dec;1(8):675-82
10196583
Annu Rev Physiol. 1999;61:497-519
10099699
J Cell Biol. 1996 Jun;133(6):1237-50
8682861
J Physiol. 2003 Dec 1;553(Pt 2):345-55
12963793
J Exp Biol. 2005 Jan;208(Pt 2):179-80
15634838
J Neurosci. 2007 Sep 12;27(37):9989-99
17855613
Science. 2009 Mar 13;323(5920):1448-53
19213879
J Physiol. 1985 Oct;367:163-81
2865362
J Neurosci. 2003 May 15;23(10):4092-9
12764096
Trends Cell Biol. 1994 Jan;4(1):1-4
14731821
J Neurosci. 2005 Dec 14;25(50):11676-83
16354926