Nitric oxide-releasing electrospun polymer microfibers.
The preparation of electrospun polymer microfibers with nitric oxide (NO)-release capabilities is described. Polymer solutions containing disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), a low-molecular-weight NO donor, were electrospun to generate fibers ranging from 100-3000 nm in diameter capable of releasing NO upon immersion in aqueous solutions under physiological conditions (pH 7.4, 37 °C), with kinetics depending on polymer composition and fiber diameter. The NO release half-life for PROLI/NO-doped electrospun fibers was 2-200 times longer than that of PROLI/NO alone. The influence of polymer concentration, applied voltage, capillary diameter, solution conductivity, flow rate, and additives on fiber properties are reported and discussed with respect to potential applications.
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
Peter N
PN
Coneski
Jessica A
JA
Nash
Mark H
MH
Schoenfisch
D055664:Electrochemical Techniques / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry*; D010316:Particle Size; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry
D020030:Nitric Oxide Donors; C102043:proline-nitric oxide; D009569:Nitric Oxide; D011392:Proline
J Am Chem Soc. 2002 Oct 16;124(41):12182-91
12371858
Biomacromolecules. 2006 Mar;7(3):987-94
16529441
Biomed Mater. 2009 Jun;4(3):035002
19390143
Am J Surg. 2002 Apr;183(4):406-12
11975928
Atheroscler Suppl. 2003 Dec;4(4):53-60
14664903
Br J Pharmacol. 2007 Jun;151(3):305-21
17401442
Adv Drug Deliv Rev. 2009 Oct 5;61(12):1065-83
19646493
Adv Drug Deliv Rev. 2009 Oct 5;61(12):1007-19
19651166
Talanta. 2008 May 15;75(3):642-50
18585126
Crit Care. 2009;13(4):218
19664175
Proc Natl Acad Sci U S A. 1987 Dec;84(24):9265-9
2827174
Free Radic Biol Med. 2008 Jul 1;45(1):18-31
18439435
Nanotechnology. 2006 Jul 28;17(14):R89-R106
19661572
Chem Rev. 2002 Apr;102(4):1091-134
11942788
J Med Chem. 1996 Oct 25;39(22):4361-5
8893830
Free Radic Biol Med. 2004 Oct 1;37(7):926-36
15336308