Successfully treated multicentric Castleman's disease with renal thrombotic microangiopathy using rituximab and corticosteroid.
Thrombotic microangiopathy (TMA) is a rare renal complication accompanied with Castleman's disease. We report the first case of TMA combined plasma cell type multicentric Castleman's disease (MCD) which was successfully treated with rituximab and corticosteroid. A previously healthy 60-year-old Korean man was admitted due to acute renal failure, thrombocytopenia, and multiple lymphadenopathies. The result of lymph node biopsy was plasma cell type Castleman's disease and TMA was revealed by kidney biopsy. After treatment with rituximab, prednisolone and temporary hemodialysis, complete remission was achieved. The combination of corticosteroid and rituximab was associated with improvement for this patient.
Seoul National University Kidney Research Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
J P
JP
Lee
D K
DK
Kim
D Y
DY
Oh
J H
JH
Paik
K C
KC
Moon
S
S
Kim
Y S
YS
Kim
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D000069283:Rituximab; D012720:Severity of Illness Index; D057049:Thrombotic Microangiopathies / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab