Targeted regeneration of bone in the osteoporotic human femur.
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.
Department of Medicine, University of Cambridge, Cambridge, United Kingdom. kp254@nhs.net
Kenneth E S
KE
Poole
Graham M
GM
Treece
Gerard R
GR
Ridgway
Paul M
PM
Mayhew
Jan
J
Borggrefe
Andrew H
AH
Gee
D000368:Aged; D015519:Bone Density; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D003952:Diagnostic Imaging / Q000379:methods* / Q000592:standards; D005260:Female; D005269:Femur / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016474:Weight-Bearing / Q000502:physiology*
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