Investigation of the recurrence patterns of gastric cancer following a curative resection.
OBJECTIVE
The goal of this study was to investigate the recurrence patterns of gastric cancer and determine the predictive information of recurrence patterns of gastric cancer following a curative resection.


METHODS
This study retrospectively analyzed the data of 308 gastric cancer patients who underwent a curative resection, to identify the factors associated with the recurrence patterns.


RESULTS
One hundred and sixty-nine gastric cancer patients had recurrence following curative resection. One hundred and twenty-six patients were observed for 3 years after the operation. Locoregional recurrence formed part of the recurrence pattern in 107 patients, peritoneal dissemination was observed in 98 patients, and distant metastasis occurred in 22 patients. A multivariate analysis revealed that locoregional recurrence was only associated with the Lauren classification (P = 0.003); peritoneal dissemination was only associated with N stage (P < 0.001); and distant metastasis was only associated with the Lauren classification (P = 0.016).


CONCLUSIONS
Locoregional recurrence, peritoneal dissemination, and distant metastasis were the most common recurrence patterns of gastric cancer following a curative resection. Each recurrence pattern is associated with specific clinicopathological factors.
Gastric Cancer Surgery Division, Tianjin Medical University Cancer Hospital and City Key Laboratory of Tianjin Cancer Center, Tianjin, PR China.
Jingyu
J
Deng
Han
H
Liang
Dianchang
D
Wang
Dan
D
Sun
Yi
Y
Pan
Yong
Y
Liu
D000368:Aged; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010534:Peritoneal Neoplasms / Q000556:secondary; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*
J Surg Oncol. 1998 Sep;69(1):15-20
9762886
J Gastrointest Surg. 2000 Sep-Oct;4(5):520-5
11077328
J Surg Oncol. 2003 Feb;82(2):104-10
12561066
World J Surg. 1988 Jun;12(3):374-81
3400248
Ai Zheng. 2005 May;24(5):596-9
15890105
Br J Surg. 2003 Sep;90(9):1113-9
12945079
Ann Surg Oncol. 2002 May;9(4):394-400
11986192
Gut. 1996 Apr;38(4):525-7
8707081
Minerva Chir. 2000 May;55(5):299-305
10953563
Cancer. 2006 Nov 1;107(9):2143-51
17001662
Br J Cancer. 1995 Dec;72(6):1518-24
8519670
Surgery. 1998 May;123(5):573-8
9591011
Arch Surg. 1992 Mar;127(3):290-4
1372495
Br J Surg. 2000 Mar;87(3):353-7
10718807
Hepatogastroenterology. 2001 Jan-Feb;48(37):279-84
11268985
Surg Gynecol Obstet. 1990 Jun;170(6):488-94
2343364
Semin Oncol. 1996 Jun;23(3):352-9
8658219
Surg Today. 2009;39(3):207-13
19280279
Cancer. 2000 Apr 15;88(8):1796-800
10760754
Br J Surg. 2000 Feb;87(2):236-42
10671934
Br J Surg. 1988 Feb;75(2):110-2
3349293
Br J Surg. 1988 Feb;75(2):106-9
3349292
Int Surg. 2000 Oct-Dec;85(4):286-90
11589593
J Am Coll Surg. 1995 Jul;181(1):56-64
7599772
Ann Surg. 2004 Nov;240(5):808-16
15492562
N Engl J Med. 1999 Mar 25;340(12):908-14
10089184
N Engl J Med. 2008 Jul 31;359(5):453-62
18669424
J Clin Oncol. 1993 Oct;11(10):1894-900
8410115
Surg Oncol Clin N Am. 2002 Jan;11(1):111-31, ix
11928796
World J Gastroenterol. 2003 Jul;9(7):1409-14
12854131
Br J Surg. 1994 Mar;81(3):414-6
8173916
Cancer. 2006 Dec 1;107(11):2576-80
17075877
Jpn J Surg. 1981 Mar;11(2):127-39
7300058
Ann Surg. 1993 Nov;218(5):583-92
8239772
Br J Cancer. 1999 Mar;79(9-10):1522-30
10188901
Arch Surg. 1987 Nov;122(11):1347-51
3675199