Cortical representation of the human hand assessed by two levels of high-resolution EEG recordings.
Increasing interest in cortical plasticity has prompted the growing use of somatosensory evoked potentials (SEPs) to estimate changes in the cortical representation of body regions. Here, we tested the effect of different sites of hand stimulation and of the density of spatial sampling in the quality of estimation of somatosensory sources. Sources of two SEP components from the primary somatosensory cortex (N20/P20 and P45) were estimated using two levels of spatial sampling (64- vs. 128-channel) and stimulation of four distal sites in the upper limbs, including single digits (first vs. fifth) and distal nerves with comparable cortical projection (superficial branch of the radial nerve and distal ulnar nerve). The most robust separation of somatosensory sources was achieved by comparing the cortical representations of the first digit and the distal ulnar nerve territories on the N20/P20 component of SEPs. Although both the 64- and the 128-electrode montages correctly discriminated these two areas, only the 128-electrode montage was able to significantly separate sources in the other cases, notably when using first versus fifth digit stimulation. Trustworthy distinction of cortical representations was not obtainable when using the P45 component, probably because of greater activation volume, radial orientation of sources in areas 1-2 and increased variability with attention and vigilance. Assessment of tangential SEP components to stimulation of first digit versus ulnar nerve appears the best option to assess plastic somatosensory changes, especially when using relatively low-electrode sampling.
Central Integration of Pain, INSERM U879/University Claude Bernard Lyon 1, France. berengere.houze@gmail.com.
Bérengère
B
Houzé
Caroline
C
Perchet
Michel
M
Magnin
Luis
L
Garcia-Larrea
D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D004525:Efferent Pathways / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D006225:Hand / Q000294:innervation* / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D011826:Radial Nerve / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D014459:Ulnar Nerve / Q000502:physiology; D055815:Young Adult
Eur J Neurosci. 1993 Jun 1;5(6):724-34
8261143
Hum Brain Mapp. 2002 Sep;17(1):28-36
12203686
Electroencephalogr Clin Neurophysiol. 1988 Aug;70(2):126-36
2456191
J Neurosci. 1995 Dec;15(12):8083-95
8613744
Electroencephalogr Clin Neurophysiol. 1995 Mar;96(2):121-34
7535218
Electroencephalogr Clin Neurophysiol. 1983 Oct;56(4):272-82
6193940
IEEE Trans Biomed Eng. 2004 Sep;51(9):1547-54
15376503
Neuroimage. 2004 Oct;23(2):462-72
15488396
Exp Brain Res. 1998 Mar;119(2):205-12
9535570
IEEE Trans Biomed Eng. 2006 Sep;53(9):1851-8
16941841
Neuroreport. 2007 Jul 16;18(11):1199-203
17589326
Pain. 2001 Feb 1;90(1-2):47-55
11166969
J Pain. 2001 Aug;2(4):220-8
14622820
Hum Brain Mapp. 2007 Mar;28(3):159-71
16761270
Science. 1998 Nov 6;282(5391):1121-5
9804550
Electroencephalogr Clin Neurophysiol. 1992 Jul-Aug;84(4):301-14
1377999
Pain. 2003 Jan;101(1-2):117-27
12507706
J Neurosci. 2001 May 15;21(10):3609-18
11331390
Neuroreport. 2000 Apr 27;11(6):1289-93
10817609
Exp Neurol. 2008 Feb;209(2):407-16
17692844
Annu Rev Neurosci. 2000;23:1-37
10845057
Brain Topogr. 2002 Spring;14(3):179-89
12002348
Clin Neurophysiol. 2003 Jun;114(6):1053-68
12804674
Psychophysiology. 1982 Mar;19(2):146-59
7071293
Clin Neurophysiol. 2001 Apr;112(4):627-35
11275535
J Neurosci. 1990 Mar;10(3):952-74
2108231
J Neurosci. 1997 Jul 15;17(14):5503-8
9204932
Parkinsonism Relat Disord. 2009 Sep;15(8):564-71
19303347
Nat Rev Neurosci. 2006 Nov;7(11):873-81
17053811
Brain Topogr. 2002 Winter;15(2):95-106
12537305
Neuroscience. 2001;102(2):263-72
11166112
IEEE Trans Biomed Eng. 2000 Nov;47(11):1487-92
11077742
Electroencephalogr Clin Neurophysiol. 1993 Jul-Aug;88(4):271-9
7688282
Neurology. 1995 Jan;45(1):154-60
7824107
Nat Neurosci. 1999 Jun;2(6):501-2
10448212
Nature. 1995 Jun 8;375(6531):482-4
7777055
J Neurosci. 2000 Dec 15;20(24):9277-83
11125006
Neurosci Lett. 1997 Mar 7;224(1):5-8
9132689
Brain Res. 1998 Jan 26;782(1-2):153-66
9519259
Eur J Neurosci. 1998 Mar;10(3):1095-102
9753177
Neuron. 1999 Apr;22(4):657-60
10230786
Electroencephalogr Clin Neurophysiol. 1985 Jan;62(1):1-17
2578373
Neurosci Lett. 2001 Feb 9;298(3):195-8
11165440
Electroencephalogr Clin Neurophysiol. 1991 May-Jun;80(3):201-14
1713151
Electroencephalogr Clin Neurophysiol. 1997 May;102(5):452-9
9191589
J Pain. 2009 Aug;10(8):854-9
19638329