Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives.
A novel series of isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives was synthesized and evaluated in vitro against various human cancer cell lines for antiproliferative activity. These new compounds displayed activity against leukemia and breast cancer cell lines in the 3- to 18-µM concentration range.
Université Bordeaux Segalen, CNRS FRE 3396, Pharmacochimie, Bordeaux.
Vanessa
V
Desplat
Stéphane
S
Moreau
Solene
S
Belisle-Fabre
Denis
D
Thiolat
Juliette
J
Uranga
Romain
R
Lucas
Laure
L
de Moor
Stéphane
S
Massip
Christian
C
Jarry
Djavad M
DM
Mossalayi
Pascal
P
Sonnet
Gérard
G
Déléris
Jean
J
Guillon
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy; D008958:Models, Molecular; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011810:Quinoxalines