Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors.
Preclinical and clinical studies suggest that whey proteins can reduce postprandial glucose levels and stimulate insulin release in healthy subjects and in subjects with type 2 diabetes by reducing dipeptidyl peptidase-4 (DPP-4) activity in the proximal bowel and hence increasing intact incretin levels. Our aim was to identify DPP-4 inhibitors among short peptides occurring in hydrolysates of β-lactoglobulin, the major whey protein found in the milk of ruminants. We proved that the bioactive peptide Ile-Pro-Ala can be regarded as a moderate DPP-4 inhibitor.
Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123 Brescia, Italy. tulipano@med.unibs.it
Giovanni
G
Tulipano
Valeria
V
Sibilia
Anna Maria
AM
Caroli
Daniela
D
Cocchi
D016022:Case-Control Studies; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008894:Milk Proteins / Q000737:chemistry*; D000067816:Whey Proteins
D054873:Dipeptidyl-Peptidase IV Inhibitors; D008894:Milk Proteins; D000067816:Whey Proteins