Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans.
Doppler optical coherence tomography has the capability to measure blood flow quantitatively and in vivo. As only the axial component of the velocity can be assessed, the measurements have to be corrected for the angle of the vessels. We present a novel approach to extract quantitative flow data from circumpapillary scans in vivo on the human retina by registering the circular scan to a reference volume scan and extracting the angle directly from the volume. In addition, we perform phase unwrapping and interpolation of the flow under the assumption of a parabolic flow profile. We demonstrate the repeatability of the methods by applying it to different retinal vessels, achieving coefficients of variation of the average velocity of 3 to 8%. Results on the pulsatility and resistance index are also presented.
Group of Biomedical Optics, Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringerstrasse 13, 1090 VIENNA, Austria.
Amardeep S G
AS
Singh
Christoph
C
Kolbitsch
Tilman
T
Schmoll
Rainer A
RA
Leitgeb
Opt Express. 2007 Jan 22;15(2):408-22
19532258
Diabetologia. 1999 Apr;42(4):387-405
10230642
Opt Express. 2008 Jul 21;16(15):11438-52
18648464
J Biomed Opt. 2007 Jul-Aug;12(4):041213
17867802
J Biomed Opt. 2008 Nov-Dec;13(6):064003
19123650
Arch Ophthalmol. 2003 Feb;121(2):235-9
12583790
Opt Express. 2008 Sep 15;16(19):15149-69
18795054
Opt Express. 2009 Mar 2;17(5):4166-76
19259253
Opt Express. 2003 Apr 21;11(8):889-94
19461802
Opt Express. 2010 Apr 12;18(8):8220-8
20588668
Opt Lett. 2008 Jul 1;33(13):1425-7
18594653
Hypertension. 2002 Feb;39(2 Pt 2):699-703
11882634
Opt Lett. 2007 Mar 1;32(5):506-8
17392903
J Biomed Opt. 2008 Jul-Aug;13(4):040505
19021308
Opt Express. 2009 Jun 22;17(13):10584-98
19550454
Opt Express. 2006 Aug 21;14(17):7821-40
19529151
Opt Express. 2008 Aug 4;16(16):12350-61
18679512
Opt Lett. 2008 Apr 15;33(8):836-8
18414549
Appl Opt. 2005 Jan 20;44(3):348-57
15717824
Opt Lett. 2003 Nov 1;28(21):2067-9
14587817
Opt Lett. 2008 Dec 15;33(24):2967-9
19079508
Opt Express. 2007 Nov 12;15(23):15193-206
19550803
J Biophotonics. 2009 Jul;2(6-7):416-25
19526469
Opt Express. 2010 Jan 18;18(2):1261-70
20173950
Invest Ophthalmol Vis Sci. 1994 Dec;35(13):4273-81
8002247
Opt Express. 2009 Dec 21;17(26):23736-54
20052085
Opt Express. 2003 Nov 17;11(23):3116-21
19471434
Opt Express. 2003 Dec 15;11(25):3490-7
19471483
Opt Lett. 2007 Jun 1;32(11):1587-9
17546197
Prog Retin Eye Res. 2002 Jul;21(4):359-93
12150988