Accelerated 20-year sunlight exposure simulation of a photochromic foldable intraocular lens in a rabbit model.
OBJECTIVE
To assess the long-term biocompatibility and photochromic stability of a new photochromic hydrophobic acrylic intraocular lens (IOL) under extended ultraviolet (UV) light exposure.


METHODS
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.


METHODS
Experimental study.


METHODS
A Matrix Aurium photochromic IOL was implanted in right eyes and a Matrix Acrylic IOL without photochromic properties (n = 6) or a single-piece AcrySof Natural SN60AT IOL (n = 5) in left eyes of 11 New Zealand rabbits. The rabbits were exposed to a UV light source of 5 mW/cm(2) for 3 hours during every 8-hour period, equivalent to 9 hours a day, and followed for up to 12 months. The photochromic changes were evaluated during slitlamp examination by shining a penlight UV source in the right eye. After the rabbits were humanely killed and the eyes enucleated, study and control IOLs were explanted and evaluated in vitro on UV exposure and studied histopathologically.


RESULTS
The photochromic IOL was as biocompatible as the control IOLs after 12 months under conditions simulating at least 20 years of UV exposure. In vitro evaluation confirmed the retained optical properties, with photochromic changes observed within 7 seconds of UV exposure. The rabbit eyes had clinical and histopathological changes expected in this model with a 12-month follow-up.


CONCLUSIONS
The new photochromic IOL turned yellow only on exposure to UV light. The photochromic changes were reversible, reproducible, and stable over time. The IOL was biocompatible with up to 12 months of accelerated UV exposure simulation.
John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA. liliana.werner@hsc.utah.edu
Liliana
L
Werner
Salwa
S
Abdel-Aziz
Carolee
C
Cutler Peck
Bryan
B
Monson
Ladan
L
Espandar
Brian
B
Zaugg
Jack
J
Stringham
Chris
C
Wilcox
Nick
N
Mamalis
D000179:Acrylates; D000818:Animals; D003116:Color; D007910:Lenses, Intraocular; D008422:Materials Testing; D011474:Prosthesis Design; D011817:Rabbits; D015203:Reproducibility of Results; D013472:Sunlight / Q000009:adverse effects*; D013997:Time Factors; D014466:Ultraviolet Rays
D000179:Acrylates
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