Microtubule dynamics: Patronin, protector of the minus end.
It has long been surmised that cellular microtubules are capped at the minus ends to prevent their depolymerization. A recent study provides the first definitive identification of a minus-end-specific capping protein, termed Patronin, which protects the microtubule arrays of both mitotic and interphase cells.
Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Brian P
BP
O'Rourke
David J
DJ
Sharp
D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D016547:Kinesins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D008870:Microtubules / Q000502:physiology*; D058105:Polymerization
D029721:Drosophila Proteins; D008869:Microtubule-Associated Proteins; C553301:patronin protein, Drosophila; D016547:Kinesins