Monocyte-derived DC maturation strategies and related pathways: a transcriptional view.
Ex vivo production of highly stimulator mature dendritic cells (DCs) for cellular therapy has been used to treat different pathological conditions with the aim of inducing a specific immune response. In the last decade, several protocols have been developed to mature monocyte-derived DCs: each one has led to the generation of DCs showing different phenotypes and stimulatory abilities, but it is not yet known which one is the best for inducing effective immune responses. We grouped several different maturation protocols according to the downstream pathways they activated and reviewed the shared features at a transcriptomic level to reveal the potential of DCs matured by each protocol to develop Th-polarized immune responses.
Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Luciano
L
Castiello
Marianna
M
Sabatino
Ping
P
Jin
Carol
C
Clayberger
Francesco M
FM
Marincola
Alan M
AM
Krensky
David F
DF
Stroncek
D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology* / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D014158:Transcription, Genetic
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