Association between endometriosis and polymorphisms in insulin-like growth factors (IGFs) and IGF-I receptor genes in Korean women.
OBJECTIVE
To evaluate the relationship between endometriosis and polymorphisms in insulin-like growth factors (IGFs) and IGF-I receptor genes.


METHODS
In a case-control study, 128 women with endometriosis and 108 control women were recruited at the Department of Obstetrics and Gynecology in Seoul National University Hospital. Determinations of -969(CA) block, -603A>T, and -553T>C single nucleotide polymorphism (SNP)s in the IGF-I gene, c.517C>T, c.540G>T and 820G>A SNPs in the IGF-II gene, and c.3129G>A SNP in the IGF-I receptor gene were performed to evaluate the prevalence of IGFs and IGF-I receptor genotypes or alleles.


RESULTS
Among studied SNPs, the IGF-II 820G>A polymorphism was associated with endometriosis. Women with endometriosis were observed 1.99 times more frequently in the GG genotype of the IGF-II 820G>A polymorphism compared with non-GG genotype (95% confidence level: 1.18-3.35). The similar finding was observed only in early stage endometriosis (stages I and II).


CONCLUSIONS
The IGF-II 820G>A polymorphism is a genetic factor which may be associated with the development of endometriosis in Korean women.
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Chongno-Ku, Seoul 110-744, Republic of Korea.
Hoon
H
Kim
Ju Hee
JH
Park
Seung-Yup
SY
Ku
Seok Hyun
SH
Kim
Young Min
YM
Choi
Jung Gu
JG
Kim
D020413:3' Untranslated Regions; D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006785:Hospitals, University; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D056910:Republic of Korea; D055815:Young Adult
D020413:3' Untranslated Regions; C035170:IGF2 protein, human; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1