Influence of inflammation on total energy expenditure in hemodialysis patients.
OBJECTIVE
Studies show that inflammation can contribute to an increase in resting energy expenditure in patients with chronic kidney disease; however, findings about total energy expenditure (TEE) have not been reported. The aim of this study was to evaluate the effects of inflammation on TEE and physical activity energy expenditure in hemodialysis (HD) patients.


METHODS
This was a cross-sectional study.


METHODS
This study was conducted from Hôpital Edouard Herriot, Lyon, France.


METHODS
This study included 24 HD patients and 18 healthy subjects.


METHODS
TEE and step counts were measured over a 7-day period by the SenseWear Pro2 Armband in 24 HD patients (15 patients with C-reactive protein <5 mg/L, aged 67.0 ± 14.7 years, and 9 with C-reactive protein >5 mg/L, aged 69.0 ± 18.0 years) and compared with 18 healthy subjects (62.3 ± 15.3 years).


RESULTS
Mean estimated TEE measured with SenseWear Pro2 Armband was significantly lower (25.5 ± 4.1 kcal/kg/day) in patients with inflammation when compared with those without inflammation (32.0 ± 6.7 kcal/kg/day) and with healthy subjects (31.8 ± 7.0 kcal/kg/day) (P = .012). There was a difference in the physical activity (step counts) between patient groups (P < .05). Healthy subjects and patients without inflammation walked more (8,107 ± 5,419 and 6,016 ± 3,752 steps/day, respectively) as compared with patients with inflammation (2,801 ± 2,754 steps/day, P = .001).


CONCLUSIONS
Our findings suggest that patients with inflammation have a lower TEE when compared with healthy subjects and patients without inflammation. TEE is influenced by physical activity because patients with inflammation appear to be less active.
Department of Clinical Nutrition, University of Federal Fluminense (UFF), Niterói, Brazil. dmafra@terra.com.br
Denise
D
Mafra
Patrick
P
Deleaval
Daniel
D
Teta
Christine
C
Cleaud
Walid
W
Arkouche
Anne
A
Jolivot
Denis
D
Fouque
D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D002153:Calorimetry, Indirect; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004734:Energy Metabolism; D005260:Female; D005602:France; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015596:Nutrition Assessment; D006435:Renal Dialysis; D012146:Rest
D002097:C-Reactive Protein