[Chemotherapy of chronic viral hepatitis B: randomized multicenter investigation results].
During treatment of patients with chronic hepatitis B the best therapeutic effect was obtained with the inclusion in the scheme of antiviral therapy cycloferon. Complete stable remission was achieved in 54.1% of patients in combination cycloferon with lamivudin, but the appointment of alpha-interferon with cycloferon provided remission 44.1% of patients resistant to treatment with lamivudin. Therapy of chronic hepatitis B with cycloferon can reduce the frequency and severity of side effects, prevents the development of resistance to lamivudin and the emergence of mutant viruses.
M G
MG
Romantsov
T V
TV
Sologub
A A
AA
Shul'diakov
L G
LG
Goriacheva
Iu N
IuN
Lin'kova
A L
AL
Kovalenko
D000166:Acridines / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects; D024882:Drug Resistance, Viral / Q000187:drug effects; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D007369:Interferon Inducers / Q000008:administration & dosage* / Q000009:adverse effects; D019259:Lamivudine / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D012074:Remission Induction
D000166:Acridines; D019380:Anti-HIV Agents; D007369:Interferon Inducers; D019259:Lamivudine; C026430:10-carboxymethyl-9-acridanone