Symptomatic vocal cord paresis/paralysis in infants operated on for esophageal atresia and/or tracheo-esophageal fistula.
OBJECTIVE
To describe the prevalence and pathogenesis of symptomatic vocal cord paresis/paralysis (VCP) in patients treated for esophageal atresia (EA), tracheo-esophageal fistula (TEF) or both.


METHODS
Retrospective study of all patients treated for EA/TEF in our center (1995 to 2009). Patients with and without symptomatic VCP were compared for gestational age, birth weight, associated anomalies, referrals, long-gap EA (> 3 cm or 3 vertebral bodies), cervical esophagostomy, anastomotic leakage, length of ventilation, and major cardiac surgery. Prevalence or median (IQR) is reported.


RESULTS
Of 174 patients, 7 (4%) had symptomatic VCP. Prevalence of referrals (5/7 versus 21/167; P = .0009), long gap (5/7 versus 41/167; P = .0146), previous cervical esophagostomy (5/7 versus 7/167; P < .0001), and anastomotic leakage (3/7 versus 10/167; P = .0097) was higher, and ventilation longer (8.5 days [7.0 to 15.5] versus 6.0 days (5.0 to 7.0); P = .0072) in patients with VCP.


CONCLUSIONS
In infants treated for EA/TEF, VCP should be ruled out in case of persistent respiratory morbidity or, when present, cautiously monitored. Surgical risk factors should be actively controlled. Further studies are needed to define the prevalence of acquired and congenital VCP in patients with EA/TEF.
Neonatal Surgery Unit, Department of Medical and Surgical Neonatology, Bambino Gesù Children's Research Hospital, Rome, Italy. francesco.morini@opbg.net
Francesco
F
Morini
Barbara D
BD
Iacobelli
Alessandro
A
Crocoli
Sergio
S
Bottero
Marilena
M
Trozzi
Andrea
A
Conforti
Pietro
P
Bagolan
D057868:Anastomotic Leak; D015331:Cohort Studies; D004933:Esophageal Atresia / Q000150:complications* / Q000601:surgery*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010243:Paralysis / Q000175:diagnosis / Q000209:etiology*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014138:Tracheoesophageal Fistula / Q000150:complications* / Q000601:surgery*; D016896:Treatment Outcome; D014826:Vocal Cord Paralysis / Q000175:diagnosis / Q000209:etiology*; D014827:Vocal Cords / Q000473:pathology