Nerve lesioning with direct current.
Spastic hypertonus (muscle over-activity due to exaggerated stretch reflexes) often develops in people with stroke, cerebral palsy, multiple sclerosis and spinal cord injury. Lesioning of nerves, e.g. with phenol or botulinum toxin is widely performed to reduce spastic hypertonus. We have explored the use of direct electrical current (DC) to lesion peripheral nerves. In a series of animal experiments, DC reduced muscle force by controlled amounts and the reduction could last several months. We conclude that in some cases controlled DC lesioning may provide an effective alternative to the less controllable molecular treatments available today.
Center for Neuroscience, University of Alberta, Edmonton, Alberta, Canada. ravid@ualberta.ca
E Natalie
EN
Ravid
Liu Shi
LS
Gan
Kathryn
K
Todd
Arthur
A
Prochazka
D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D002415:Cats; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D011817:Rabbits; D013979:Tibial Nerve / Q000473:pathology* / Q000502:physiology*; D014160:Transducers, Pressure