Perinatal outcome of twice-frozen-thawed embryo transfers: a clinical follow-up study.
We evaluated our clinical data on refrozen-thawed ETs (92 cycles) and found that human embryos were capable of withstanding two freeze-thaw cycles, resulting in normal live births after transfer at a rate similar to that of primary frozen-thawed embryos. This is the first follow-up study to present perinatal outcomes of children born after embryo re-cryopreservation, and our results should encourage clinicians to explore the possibility of performing the refreezing procedure.
Kuramoto Women's Clinic, Fukuoka, Japan. murakami@kuramoto.or.jp
Masao
M
Murakami
Akiyoshi
A
Egashira
Kimiko
K
Murakami
Yasuhisa
Y
Araki
Takeshi
T
Kuramoto
D000328:Adult; D001755:Blastocyst; D016009:Chi-Square Distribution; D015925:Cryopreservation; D046149:Embryo Culture Techniques; D004624:Embryo Transfer / Q000009:adverse effects; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007564:Japan; D050498:Live Birth; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D017694:Rewarming / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult