[Cytogenetic mechanisms of aneuploidy in somatic cells of chemonuclear industry professionals with incorporated plutonium-239].
Risks related to occupational exposure of humans to ionizing radiation remains a focus of attention. Of special importance is the poorly understood effect of ionizing radiation on the rate of numerical chromosome aberrations in human somatic cells. The purpose of this study was characterization of a radiation-induced increase in the rate of aneuploidy induced by incorporated plutonium-239 (239Pu) in somatic cells of chemonuclear industry workers. Significant differences in the chromosome 2, 7, 8, 12, and Y aneuploidy rate have been found between subjects with incorporated 239Pu and control subjects have been demonstrated. Chromosome nondisjunction has been found to be the main mechanism of aneuploidy induced by incorporated 239Pu.
S A
SA
Vasil'ev
V A
VA
Timoshevskiĭ
I N
IN
Lebedev
D000328:Adult; D000368:Aged; D000782:Aneuploidy; D001822:Body Burden; D002877:Chromosomes, Human; D020732:Cytogenetic Analysis; D005720:Gamma Rays; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011005:Plutonium; D011868:Radioisotopes
D011868:Radioisotopes; D011005:Plutonium