Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection.
A 45-year-old man with chronic active Epstein-Barr virus (EBV) infection (CAEBV) with natural killer cell type developed pulmonary arterial hypertension (PAH). After chemotherapy, he showed marked depression of the EBV DNA genome in the peripheral blood, but PAH sustained. He died of heart failure due to PAH, and the histo-pathological examination revealed pulmonary vascular abnormalities without lung disease on autopsy. Although the EBV DNA genome and the infiltrating lymphocytes were not detected in the lung, his clinical course suggested that his PAH might be caused by CAEBV. This is the first reported case of PAH associated CAEBV in an adult.
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Takahiro
T
Hashimoto
Yasushi
Y
Sakata
Kentaro
K
Fukushima
Tetsuo
T
Maeda
Yoh
Y
Arita
Wataru
W
Shioyama
Yoshikazu
Y
Nakaoka
Yumiko
Y
Hori
Eiichi
E
Morii
Katsuyuki
K
Aozasa
Yuzuru
Y
Kanakura
Keiko
K
Yamauchi-Takihara
Issei
I
Komuro
D002908:Chronic Disease; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D017809:Fatal Outcome; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged