Pre- and post- GPi DBS neuropsychological profiles in a case of X-linked dystonia-Parkinsonism.
We present the pre to post bilateral globus pallidus interna (GPi) deep brain stimulation neuropsychological profiles of a 69-year-old patient with a 12-year history of X-linked dystonia-Parkinsonism (XDP). Pre-operative cognitive function was impaired in almost all domains and this impaired performance was not dependent on his medications. Following DBS, changes in neuropsychological functioning were examined using Reliable Change Indices and standardized z-score comparisons. Results showed reductions in processing speed in the context of stable performance in language and visuospatial domains. Post-operative improvements occurred on a cognitive screening measure, verbal memory, and a test of problem-solving skills. This is the first report on an individual with XDP who was cognitively impaired, but had good outcome following GPi bilateral stimulation to treat debilitating motor symptoms. The possible mechanisms for his stable cognitive performance include the target of his DBS, reduced medication dosage, and improvement in dystonia that may in turn have reduced patient's pain.
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA. nkemmotsu@ucsd.edu
Nobuko
N
Kemmotsu
Catherine C
CC
Price
Genko
G
Oyama
Michael S
MS
Okun
Kelly D
KD
Foote
Laura L S
LL
Howe
Dawn
D
Bowers
D000368:Aged; D003072:Cognition Disorders / Q000209:etiology / Q000628:therapy*; D046690:Deep Brain Stimulation / Q000379:methods*; D004421:Dystonia / Q000150:complications / Q000628:therapy; D050172:Genes, X-Linked; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D020734:Parkinsonian Disorders / Q000150:complications / Q000628:therapy; D020531:Subthalamic Nucleus / Q000502:physiology*
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