Recurrent thyroid cancer with changing histologic features.
We present the case of a 57-year-old woman diagnosed with breast cancer and a thyroid mass that was suspicious for cancer. The breast cancer was estrogen and progesterone receptor negative, HER2/neu borderline, with a high proliferative index. Treatment of this cancer took precedence. Nine months later, a total thyroidectomy was done for papillary thyroid cancer with metastases to 2 of 8 perithyroid lymph nodes. Postoperative radioactive iodine ablation was given. Recurrent thyroid disease was found in the right neck 1 year later and was resected; no radioactive iodine was given at that time. After 2½ years, the cancer recurred as a more highly aggressive, undifferentiated anaplastic thyroid carcinoma. Treatment is discussed.
Departments of Pathology (Shiller), Oncology (Konduri), Nuclear Radiology (Harshman), Endocrinology (Welch), and Surgery (O'Brien), Baylor University Medical Center at Dallas and Baylor Sammons Cancer Center, Dallas, Texas.
S Michelle
SM
Shiller
Kartik
K
Konduri
Leeanne K
LK
Harshman
Brian J
BJ
Welch
John C
JC
O'Brien
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