Nanoscale coordination polymers exhibiting luminescence properties and NMR relaxivity.
This article presents the first example of ultra-small (3-4 nm) magneto-luminescent cyano-bridged coordination polymer nanoparticles Ln0.33(3+)Gdx3+/[Mo(CN)8]3- (Ln=Eu (x=0.34), Tb (x=0.35)) enwrapped by a natural biocompatible polymer chitosan. The aqueous colloidal solutions of these nanoparticles present a luminescence characteristic of the corresponding lanthanides (5D0→7F0-4 (Eu3+) or the 5D4→7F6-2 (Tb3+)) under UV excitation and a green luminescence of the chitosan shell under excitation in the visible region. Magnetic Resonance Imaging (MRI) efficiency, i.e. the nuclear relaxivity, measurements performed for Ln0.33(3+)Gdx3+/[Mo(CN)8]3- nanoparticles show r1p and r2p relaxivities slightly higher than or comparable to the ones of the commercial paramagnetic compounds Gd-DTPA® or Omniscan® indicating that our samples may potentially be considered as a positive contrast agent for MRI. The in vitro studies performed on these nanoparticles show that they maybe internalized into human cancer and normal cells and well detected by fluorescence at the single cell level. They present high stability even at low pH and lack of cytotoxicity both in human cancer and normal cells.
Institut Charles Gerhardt Montpellier, UMR5253, Chimie Moléculaire et Organisation du Solide, Université Montpellier II, Place E. Bataillon, 34095, Montpellier cedex 5, France.
Elena
E
Chelebaeva
Joulia
J
Larionova
Yannick
Y
Guari
Rute A S
RA
Ferreira
Luis D
LD
Carlos
Alexander A
AA
Trifonov
Thangavel
T
Kalaivani
Alessandro
A
Lascialfari
Christian
C
Guérin
Karine
K
Molvinger
Lucien
L
Datas
Marie
M
Maynadier
Magali
M
Gary-Bobo
Marcel
M
Garcia
D008163:Luminescent Measurements / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
D011108:Polymers