An antihistamine decongestant in the prevention of acute otitis media in children with colds.
Most clinical drug trials relating to acute otitis media have evaluated medications in terms of treatment. In this randomized double-blind, cross-over study, the effectiveness of an antihistamine decongestant in the prevention of AOM was investigated, rather than the treatment. The medication/placebo was started at the onset of a cold and continued throughout its duration. No treatment effect was evident in the results obtained with 308 children who completed the eight-month study. However, the results indicated a strong relationship between colds and AOM, and a trend toward higher occurrence of AOM in children under four years of age.
R
R
Brownoff
L J
LJ
Hutchison
Pediatrics. 1979 Mar;63(3):483-5
440849
Iowa Med. 1986 Apr;76(4):185-6, 188-9
3700057
Acta Otolaryngol. 1982 May-Jun;93(5-6):447-53
7102301
South Med J. 1979 Aug;72(8):953-5
382379
Alaska Med. 1966 Sep;8(3):64-7
5976316
J Pediatr. 1982 Jul;101(1):132-6
6177846
Ann Otol Rhinol Laryngol Suppl. 1980 May-Jun;89(3 Pt 2):290-5
6778330
J Fam Pract. 1986 Jan;22(1):39-43
3510268
Acta Otolaryngol. 1978 Sep-Oct;86(3-4):248-50
360764
Am J Dis Child. 1967 Aug;114(2):123-30
4952777
J Otolaryngol. 1981 Oct;10(5):359-62
7199092
Ann Otol Rhinol Laryngol. 1975 Mar-Apr;84(2 PT2 SUPPL 19):67-72
1093478
Am J Dis Child. 1965 Apr;109:308-13
14261009
J Fam Pract. 1983 Aug;17(2):219-27
6348203
N Engl J Med. 1983 Feb 10;308(6):297-301
6337322
J Otolaryngol. 1978 Jun;7(3):257-61
357754
Pediatr Clin North Am. 1981 Nov;28(4):727-55
7198219
Public Health Rep. 1986 May-Jun;101(3):289-93
3086922