Targeting focal adhesion kinase in neuroblastoma.
Neuroblastoma is the most common extracranial solid tumor encountered in children, and continues to carry a dismal prognosis. Focal adhesion kinase (FAK) has been shown to be upregulated in a number of human tumors and is related to tumor virulence and patient prognosis. We have demonstrated FAK expression in human neuroblastoma cell lines and tumors, and have shown that FAK is important for neuroblastoma tumor cell viability. We have also demonstrated that FAK inhibition through a number of different methods results in decreased neuroblastoma survival both in vitro and in vivo. The current review addresses the merit of further exploring FAK inhibition as a novel treatment for neuroblastoma.
Department of Surgery, University of Alabama, Birmingham, 35233, USA. elizabeth.beierle@chsys.org
Lauren
L
Gillory
Elizabeth A
EA
Beierle
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D009447:Neuroblastoma / Q000188:drug therapy* / Q000201:enzymology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D051416:Focal Adhesion Protein-Tyrosine Kinases
BMC Cancer. 2009 Feb 17;9:57
19222860
J Biol Chem. 2002 Jul 26;277(30):27393-400
12011046
Science. 1984 Jun 8;224(4653):1121-4
6719137
J Hematol Oncol. 2008 Oct 29;1:20
18959794
Mol Carcinog. 2010 Feb;49(2):200-9
19885860
Oncogene. 1997 Mar 20;14(11):1341-50
9178894
Clin Cancer Res. 2000 Jun;6(6):2417-23
10873094
J Med Chem. 2008 Dec 11;51(23):7405-16
18989950
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1772-6
2869488
Biochem Biophys Res Commun. 2007 Jan 12;352(2):571-7
17140547
Cancer Res. 2007 Nov 15;67(22):10976-83
18006843
Mol Carcinog. 2010 Mar;49(3):224-34
19885861
J Biol Chem. 2000 Sep 29;275(39):30597-604
10899173
Mol Cell Biol. 1990 May;10(5):2012-6
2183016
World J Surg. 2006 Feb;30(2):219-26
16425085
Lancet Oncol. 2008 Mar;9(3):247-56
18308250
Int J Oncol. 2008 Oct;33(4):815-21
18813796
J Surg Res. 2004 Jun 1;119(1):56-65
15126083
Clin Cancer Res. 2008 Jun 1;14(11):3299-305
18519756
Exp Cell Res. 1994 Sep;214(1):313-22
8082734
Biochem Biophys Res Commun. 2003 Nov 21;311(3):786-92
14623342
World J Surg. 2005 Mar;29(3):317-24
15706435
Lung Cancer. 2007 Nov;58(2):205-13
17686546
Clin Exp Metastasis. 1995 Mar;13(2):123-33
7533687
J Med Chem. 2009 Aug 13;52(15):4716-24
19610651
Mod Pathol. 2005 Oct;18(10):1289-94
15861214
J Biol Chem. 1997 Feb 21;272(8):5214-8
9030591
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14094-9
18780787
Oncogene. 1995 Dec 21;11(12):2599-607
8545117
Cell Cycle. 2010 Mar 1;9(5):1005-15
20160475
Nat Cell Biol. 2010 Mar;12(3):247-56
20173740
Oncogene. 2008 Feb 28;27(10):1439-48
17828307
Oncol Rep. 2008 Dec;20(6):1473-7
19020730
Prostate. 2005 Oct 1;65(2):110-6
15880525
Expert Opin Investig Drugs. 2010 Jun;19(6):777-88
20465362
Mol Carcinog. 2007 Jun;46(6):488-96
17219439
J Pediatr Surg. 1998 Dec;33(12):1765-70
9869047
Am J Surg. 2010 Nov;200(5):610-4
21056138
Eur J Cancer. 2006 Sep;42(13):2081-91
16919772
Cancer Metastasis Rev. 2003 Dec;22(4):359-74
12884911
Neoplasia. 2003 Sep-Oct;5(5):405-16
14670178
Cancer Invest. 2008 Mar;26(2):145-51
18259944
Cancer Res. 2006 Feb 1;66(3):1446-54
16452200
J Biol Chem. 2007 Apr 27;282(17):12503-16
17327229
Eur J Cancer. 1995;31A(4):549-52
7576965
BMC Cancer. 2009 Aug 12;9:280
19671193
J Clin Oncol. 1999 Jul;17(7):2264-79
10561284
Cell Cycle. 2009 Aug;8(15):2435-43
19571674
Cancer Res. 1990 Jul 15;50(14):4411-6
2364393
J Biol Chem. 2002 Oct 11;277(41):38978-87
12167618
Am J Clin Pathol. 2007 Nov;128(5):759-66
17951197
Cancer. 1999 Oct 15;86(8):1551-6
10526262
J Pediatr Surg. 2003 Mar;38(3):514-21
12632379