Prevalence of HBV infection among different HIV-risk groups in Hai Phong, Vietnam.
Hepatitis B virus (HBV) infection in Hai Phong, northern Vietnam, was characterized by analyzing the prevalence and genotype distribution of HBV as well as co-infection with human immunodeficiency virus type 1 (HIV-1) among five different risk groups for HIV infection. Plasma samples were collected from intravenous drug users (n=760, anti-HIV-1 antibody positive rate: 35.9%), female sex workers (FSWs; n=91, 23.1%), seafarers (n=94, 0%), pregnant women (n=200, 0.5%), and blood donors (n=210, 2.9%) in 2007 [Ishizaki et al. (2009): AIDS Res Hum Retroviruses 25:175-182]. Samples were screened for the hepatitis B surface antigen (HBsAg) and anti-HBs antibody and analyzed genetically. The cumulative HBV incidence rate (HBsAg+anti-HBs) was 53.2% (10.7+42.5%) in intravenous drug users, 51.6% (11.0+40.6%) in FSWs, 54.3% (9.6+44.7%) in seafarers, 50.5% (12.5+38.0%) in pregnant women, and 51.0% (18.1+32.9%) in blood donors; there was no significant difference among these groups. Of 163 HBsAg-positive samples, 113 could be analyzed genetically. Phylogenetic analysis, based on the preS1 region, revealed genotype B4 was most prevalent (90/113; 79.6%), followed by C1 (17.7%), I1 (1.8%), and B2 (0.9%). There was no significant difference in HBV genotype distribution among different HIV infection-risk groups. The prevalence of HBsAg was 10.3% (31/301) in HIV-1-infected individuals and 12.5% (132/1,054) in non-HIV-1-infected individuals, which was not significant. In addition, no significant difference in HBV genotype distribution was observed between HBV/HIV-1 coinfected and HBV mono-infected groups. These results suggest that, although HBV and HIV-1 share modes of transmission, major transmission routes of HBV have been different from those of HIV-1 in Hai Phong, Vietnam.
Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Cuong Hung
CH
Nguyen
Azumi
A
Ishizaki
Phan Thi Thu
PT
Chung
Huyen Thi
HT
Hoang
Trung Vu
TV
Nguyen
Tomoaki
T
Tanimoto
Raphael
R
Lihana
Kaori
K
Matsushita
Xiuqiong
X
Bi
Thuc Van
TV
Pham
Hiroshi
H
Ichimura
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology* / Q000635:transmission; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D011247:Pregnancy; D015995:Prevalence; D011498:Protein Precursors / Q000235:genetics; D012307:Risk Factors; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; C050806:presurface protein 1, hepatitis B surface antigen