[Fertility preservation for young patients with autoimmune diseases and the need for cytotoxic treatment. Clinical experiences from interdisciplinary consultation].
In cases of severe exacerbation of autoimmune diseases (AID) cytotoxic therapy, in particular with cyclophosphamide (CYC) is needed. As the peak occurrence of such AIDs occurs in young women during the childbearing years, preservation of fertility and the hormonal function of the ovaries are an interdisciplinary challenge.For ovarian protection several options exist. Gonadotropin-releasing hormone analogues in parallel with CYC treatment seem to reduce the cytotoxic effect on the ovaries. Fertilized and unfertilized oocytes can be conserved by cryoconservation after ovarian stimulation. A relatively new strategy uses cryopreservation and autotransplantation of human ovarian tissue prior to cytotoxic therapy. As all these methods are accompanied with side-effects and possible delays in the necessary CYC treatment, a close collaboration of gynecologists and internists is needed. The decision for the optimal preservation therapy should always be based on the individual patient.
Abteilung für Innere Medizin II (Onkologie, Haematologie, Immunologie, Rheumatologie, Pulmologie), Universitätsfrauenklinik Tübingen, Universitätsklinikum Tübingen, Otfried-Mueller-Strasse 10, Tübingen, Germany. joerg.henes@med.uni-tuebingen.de
M
M
Henes
J C
JC
Henes
M
M
Schmalzing
E
E
Neunhoeffer
R
R
Rothmund
I
I
Kötter
B
B
Lawrenz
D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy*; D003603:Cytotoxins / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D007247:Infertility, Female / Q000139:chemically induced* / Q000517:prevention & control*; D010348:Patient Care Team
D003603:Cytotoxins; D007166:Immunosuppressive Agents
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