Putting the brakes on the anti-viral response: negative regulators of type I interferon (IFN) production.
Type I IFNs (IFNα/β) are essential anti-viral cytokines produced in response to the detection of viral components by host pattern recognition receptors. IFNα/β production is transient, and aberrant activation can be hazardous to the host. In this article, we review our current understanding of host negative regulatory mechanisms that control IFNα/β production.
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
Kathryn H
KH
Richards
Andrew
A
Macdonald
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D056747:Immunomodulation; D050835:Interferon Regulatory Factors / Q000378:metabolism; D007370:Interferon Type I / Q000096:biosynthesis* / Q000276:immunology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000276:immunology
D050835:Interferon Regulatory Factors; D007370:Interferon Type I; D012367:RNA, Viral; D051193:Toll-Like Receptors; D017346:Protein Serine-Threonine Kinases