[The evolution of medical research: from trials to tailored therapy].
Medical research and consequently therapy are undergoing dramatic transformation. New science on genomics and proteomics has given us important information on the pathophysiology of many cardiac diseases and personalized responses to specific patient-oriented therapies. The application of cellular genetic and proteome tests is a promising field of research and their clinical use can allow us to both: 1) understand the causes and evolution of heart diseases such as ischemia and heart failure better, 2) lead to personalized medicine. This article focuses on the basic intracellular-related evidence and the unsolved problems and complexity of intracellular signaling that still need to be studied to understand personalized therapies better. In addition, we provide preliminary clinical data that support the potentiality of this new but fundamental approach of curing patients according to their genetic expression and/or protein activation that influence personalized development and the management of cardiovascular diseases.
Fondazione S. Maugeri, IRCCS Centro Medico di Lumezzane, Lumezzane (BS), Italy. evpasini@libero.it
Evasio
E
Pasini
Salvatore
S
Pirelli
Andrea
A
Di Lenarda
Francesco S
FS
Dioguardi
Attilio
A
Maseri
D035843:Biomedical Research / Q000639:trends*; D002986:Clinical Trials as Topic; D023281:Genomics / Q000639:trends; D006331:Heart Diseases / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D006333:Heart Failure / Q000235:genetics; D006801:Humans; D017202:Myocardial Ischemia / Q000235:genetics; D040901:Proteomics / Q000639:trends