Plasmablastic lymphoma involving the penis: a previously unreported location of a case with aberrant CD3 expression.
Lymphomas of the penis are rare and can either arise at this site or be a manifestation of systemic disease. We report the case of an elderly man with a plasmablastic lymphoma (PBL) involving the uncircumcised penile prepuce. The neoplasm was composed of plasmablasts positive for monotypic immunoglobulin lambda light chain, CD3, CD79a, CD138 and Epstein-Barr virus encoded RNA (EBER), and was negative for CD2, CD5, CD7, CD20, and PAX5. This case is highly unusual for at least two reasons. The penile foreskin is a rare location for lymphoma and PBL at this site has not been reported. Secondly, the tumour was shown by immunohistochemistry to be positive for the T-cell marker CD3. Lineage ambiguity in terminally differentiated B-cell lymphomas has been reported to be closely related with immune compromise and is associated with Epstein-Barr virus infection. The literature on penile lymphomas is also reviewed.
Department of Hematopathology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Jianlan
J
Sun
L Jeffrey
LJ
Medeiros
Pei
P
Lin
Gary
G
Lu
Carlos E
CE
Bueso-Ramos
M James
MJ
You
D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D017252:CD3 Complex / Q000378:metabolism*; D052816:Foreskin / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D010412:Penile Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010954:Plasmacytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor; D017252:CD3 Complex