Investigating the genetics of visual processing, function and behaviour in zebrafish.
Over the past three decades, the zebrafish has been proven to be an excellent model to investigate the genetic control of vertebrate embryonic development, and it is now also increasingly used to study behaviour and adult physiology. Moreover, mutagenesis approaches have resulted in large collections of mutants with phenotypes that resemble human pathologies, suggesting that these lines can be used to model diseases and screen drug candidates. With the recent development of new methods for gene targeting and manipulating or monitoring gene expression, the range of genetic modifications now possible in zebrafish is increasing rapidly. Combined with the classical strengths of the zebrafish as a model organism, these advances are set to substantially expand the type of biological questions that can be addressed in this species. In this review, we outline how the potential of the zebrafish can be harvested in the context of eye development and visual function. We review recent technological advances used to study the formation of the eyes and visual areas of the brain, visual processing on the cellular, subcellular and molecular level, and the genetics of visual behaviour in vertebrates.
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Sabine L
SL
Renninger
Helia B
HB
Schonthaler
Stephan C F
SC
Neuhauss
Ralf
R
Dahm
D000328:Adult; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005821:Genetic Techniques; D006801:Humans; D023421:Models, Animal; D008954:Models, Biological; D014785:Vision, Ocular / Q000235:genetics* / Q000502:physiology*; D014796:Visual Perception / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics / Q000502:physiology
Science. 2000 Sep 22;289(5487):2137-9
11000118
J Neurosci. 2008 Jan 30;28(5):1109-17
18234889
Development. 2005 Jul;132(13):2955-67
15930106
Dev Dyn. 2005 Oct;234(2):244-54
16110506
Neuron. 2007 May 24;54(4):535-45
17521567
Dev Dyn. 2004 Oct;231(2):449-59
15366023
BMC Dev Biol. 2006 Jul 26;6:36
16872490
Neural Dev. 2007 Mar 15;2:6
17359546
Dev Dyn. 2005 Aug;233(4):1366-77
15977183
Nucleic Acids Res. 1999 Nov 15;27(22):4324-7
10536138
J Cell Sci. 2008 Jun 1;121(11):1907-15
18492793
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4600-5
17360570
J Neurosci. 2007 May 16;27(20):5271-9
17507550
Nature. 2007 Jun 7;447(7145):714-9
17554307
Genome Biol Evol. 2009 Nov 25;1:479-93
20333216
Biochem Cell Biol. 1997;75(5):551-62
9551179
Dev Cell. 2004 Jul;7(1):133-44
15239961
Nature. 2007 Nov 1;450(7166):56-62
17972876
Vision Res. 2005 Apr;45(8):991-1002
15695184
Nat Biotechnol. 2005 Aug;23(8):967-73
16082368
Methods. 2006 Jul;39(3):207-11
16837210
Genesis. 2006 Mar;44(3):136-42
16496337
Development. 1996 Dec;123:415-25
9007259
Development. 1996 Dec;123:37-46
9007227
Dev Biol. 2001 May 15;233(2):329-46
11336499
J Neurosci. 2005 Oct 5;25(40):9294-303
16207889
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17968-73
19805086
BMC Genomics. 2004 Sep 03;5(1):62
15347431
J Vis Exp. 2008 Oct 03;(20):
19078942
Nature. 2005 Apr 21;434(7036):1022-6
15846347
Methods Cell Biol. 2004;77:53-68
15602905
BMC Dev Biol. 2005 Jun 28;5:12
15985175
BMC Evol Biol. 2009 Jun 05;9:127
19500364
Mol Vis. 2009 Nov 13;15:2313-25
19936306
Brain Cell Biol. 2008 Aug;36(1-4):53-67
18679801
Brain Cell Biol. 2008 Aug;36(1-4):141-54
18931914
Genes Dev. 1999 Oct 15;13(20):2713-24
10541557
Dis Model Mech. 2010 May-Jun;3(5-6):343-53
20335444
J Neurosci. 2006 Jun 7;26(23):6303-13
16763038
Nat Neurosci. 2007 Dec;10(12):1529-37
17982451
J Neurosci. 2007 Dec 12;27(50):13866-74
18077698
Dev Growth Differ. 2008 Aug;50(6):391-9
18482403
Dev Neurobiol. 2008 Feb 1;68(2):166-81
18000816
PLoS One. 2009;4(2):e4640
19247481
Dev Dyn. 2009 Sep;238(9):2254-65
19504455
Nature. 1996 Oct 31;383(6603):829-32
8893009
Nat Biotechnol. 2008 Jun;26(6):702-8
18500334
Nat Methods. 2009 Dec;6(12):875-81
19898485
Curr Biol. 2000 May 18;10(10):595-8
10837226
Methods Mol Biol. 2008;461:521-39
19030821
Vis Neurosci. 1999 May-Jun;16(3):417-24
10349963
Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12428-33
17640903
Neuron. 2006 Nov 22;52(4):609-21
17114046
J Neurosci. 2007 Jun 27;27(26):7028-40
17596452
Brain Cell Biol. 2008 Aug;36(1-4):129-39
18677566
Zebrafish. 2006;3(2):191-201
18248260
Nat Protoc. 2009;4(12):1855-67
20010934
Zebrafish. 2004;1(3):257-71
18248236
J Comp Neurol. 2010 Mar 15;518(6):800-14
20058308
Nat Methods. 2007 Apr;4(4):323-6
17369834
Science. 2008 Nov 14;322(5904):1065-9
18845710
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7777-82
8755552
Transgenic Res. 2006 Feb;15(1):21-30
16475007
Development. 2005 Jun;132(12):2861-71
15930115
Mar Biotechnol (NY). 2007 Jul-Aug;9(4):420-8
17503154
J Comp Neurol. 1984 Mar 20;224(1):116-22
6715575
J Comp Neurol. 1994 Aug 22;346(4):583-600
7983245
BMC Genomics. 2009 Sep 08;10:418
19737393
Methods Enzymol. 2000;327:522-46
11045007
Dev Neurobiol. 2007 Jul;67(8):1009-31
17565703
Dev Biol. 2007 Apr 15;304(2):811-24
17335798
Nat Biotechnol. 2006 Apr;24(4):461-5
16550175
Genetics. 1999 Apr;151(4):1531-45
10101175
Dev Dyn. 2005 Nov;234(3):670-81
16110511
Nat Chem Biol. 2007 Mar;3(3):154-5
17237798
J Comp Neurol. 1999 Feb 22;404(4):515-36
9987995
J Neurosci. 2006 Sep 27;26(39):9873-80
17005851
Dev Biol. 2008 Aug 1;320(1):113-21
18544450
Vis Neurosci. 1999 Sep-Oct;16(5):881-8
10580723
Exp Eye Res. 2006 Apr;82(4):558-75
16199033
Dev Dyn. 1995 Jul;203(3):253-310
8589427
Bioessays. 2005 Sep;27(9):937-45
16108068
Dev Genet. 1997;20(3):288-95
9216068
Genesis. 2009 Jul;47(7):484-91
19415631
Vision Res. 1998 May;38(10):1335-9
9667001
Curr Issues Mol Biol. 2004 Jan;6(1):43-55
14632258
Nat Biotechnol. 2001 Feb;19(2):137-41
11175727
Mech Dev. 2006 Jul;123(7):513-29
16859902
Curr Opin Neurobiol. 2009 Oct;19(5):553-60
19781935
Vis Neurosci. 2005 May-Jun;22(3):275-81
16079003
Nat Methods. 2008 Sep;5(9):805-11
19160515
Invest Ophthalmol Vis Sci. 2008 Sep;49(9):3812-20
18502992
Trends Genet. 2006 Sep;22(9):473-8
16844256
Dev Dyn. 2001 Dec;222(4):564-70
11748826
Dev Dyn. 2009 Mar;238(3):641-55
19191223
Dev Psychobiol. 1997 Dec;31(4):267-76
9413674
J Neurosci. 2010 Aug 11;30(32):10939-51
20702722
Dev Biol. 1999 Mar 15;207(2):309-21
10068465
Dev Dyn. 2011 Jan;240(1):108-15
21117149
Neuron. 2007 Nov 21;56(4):597-603
18031679
J Neurosci. 2003 May 1;23(9):3726-34
12736343
Dev Biol. 2005 Aug 15;284(2):421-36
16024012
Mol Genet Genomics. 2009 May;281(5):551-63
19221799
J Neurosci. 2008 Aug 13;28(33):8208-16
18701683
Neuron. 2005 Oct 20;48(2):189-99
16242400
Nature. 1997 Aug 28;388(6645):882-7
9278050
Dev Dyn. 2005 Oct;234(2):255-68
16127723
Neuron. 2005 Jul 21;47(2):231-42
16039565
Mar Biotechnol (NY). 2006 Jul-Aug;8(4):329-45
16670967
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9310-5
19474300
Development. 2008 Jan;135(1):159-69
18065431
PLoS One. 2009;4(2):e4348
19198653
Curr Opin Neurobiol. 2004 Dec;14(6):707-14
15582372
Development. 2008 Jan;135(2):387-99
18077594
Neuron. 2005 Mar 24;45(6):941-51
15797554
Nat Genet. 2002 Jun;31(2):135-40
12006978
Neuron. 2004 Jun 10;42(5):703-16
15182712
J Mol Biol. 1984 Sep 15;178(2):481-6
6333513
Development. 1996 Dec;123:427-38
9007260
Neuron. 2000 Sep;27(3):447-59
11055428
Development. 2006 Dec;133(23):4613-7
17079266
Nat Neurosci. 2010 Apr;13(4):513-20
20305645
J Neurochem. 2009 Jul;110(2):441-56
19457087
Zebrafish. 2008 Summer;5(2):121-3
18554175
Exp Eye Res. 2007 Jul;85(1):74-89
17467692
J Neurophysiol. 2003 Dec;90(6):3986-97
12930818
Development. 2005 Sep;132(17):3799-811
16049110
Nature. 2009 Sep 17;461(7262):407-10
19759620
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12792-7
15256591
Mol Vis. 2005 Sep 20;11:775-91
16205622
Genome Res. 2000 Dec;10(12):1890-902
11116085
J Neurosci. 2007 Feb 14;27(7):1712-24
17301179
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1255-60
18202183
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):893-905
18836173
Genome Biol. 2007;8 Suppl 1:S4
18047696
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13365-70
19628697
Zebrafish. 2008 Summer;5(2):97-110
18554173
Front Neural Circuits. 2009 Oct 09;3:13
19862330
BMC Neurosci. 2009 Aug 27;10:107
19712466
J Neurosci. 2010 Sep 8;30(36):11951-61
20826659
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10545-9
7479837
Genetics. 2005 May;170(1):245-61
15716491
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10887-90
8855277
Dev Biol. 1996 Dec 15;180(2):646-63
8954734
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1540-6
19834024
PLoS Biol. 2009 Oct;7(10):e1000214
19823566
J Comp Neurol. 1994 Jun 22;344(4):532-42
7929890
PLoS Genet. 2005 Nov;1(5):e66
16311625
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12651-6
12271129
Nat Chem Biol. 2006 Jan;2(1):47-52
16408092
Nat Biotechnol. 2008 Jun;26(6):695-701
18500337
Dev Dyn. 2009 Jul;238(7):1827-35
19504459
Nat Protoc. 2010 Dec;5(12):1903-10
21127484
J Neurosci. 2006 Mar 29;26(13):3604-14
16571769
Dev Psychobiol. 1974 Jan;7(1):47-60
4812270
Brief Funct Genomic Proteomic. 2008 Nov;7(6):427-43
18977782
Mech Dev. 2008 Nov-Dec;125(11-12):932-46
18824093
Nature. 1981 May 28;291(5813):293-6
7248006
Dev Dyn. 2007 Apr;236(4):1025-35
17326133
J Comp Neurol. 1996 Jul 22;371(2):222-34
8835728
J Neurosci. 1999 Oct 1;19(19):8603-15
10493760
Neuron. 2008 Mar 13;57(5):634-60
18341986
Development. 1996 Dec;123:1-36
9007226
J Neurobiol. 2003 Sep 5;56(3):222-36
12884262
Genesis. 2007 Oct;45(10):625-9
17941043
J Neurosci. 2010 May 19;30(20):7111-20
20484654
Zebrafish. 2009 Mar;6(1):69-77
19374550
Nat Methods. 2009 Dec;6(12):911-6
19898487
Nat Neurosci. 2004 Mar;7(3):254-60
14758365
Dev Biol. 2005 May 1;281(1):53-65
15848388
Nat Neurosci. 2000 Nov;3(11):1128-33
11036270