[Possible ways of MSCs influence on the ischemic tissue in the case of cardiovascular diseases].
Mesenchymal stem cells (MSCs) therapy is a modern and promising approach to the treatment of cardiovascular diseases. The background of MSCs therapeutic usage was their ability to differentiate into cardiomyocytes and neuronal lineage cells. It has been experimentally proven that MSCs transplantation accelerates inflammation in the ischemic region, activates angiogenesis, prevents apoptosis and acts as a protective agent in the areas adjacent to infarction. This reduces the size of the scar and the volume of damaged tissue, restores the functioning of the injured organ, and returns the standard rates of behavioral and neurological reactions of the experimental animals.
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Sokolova
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Pavlichenko
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000628:therapy*; D002454:Cell Differentiation; D006801:Humans; D007511:Ischemia / Q000378:metabolism / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D020127:Recovery of Function