Synthesis and radioprotective properties of pulvinic acid derivatives.
A high-throughput screening method has highlighted the marked antioxidant activity of some pulvinic acid derivatives (PADs) towards oxidation of thymidine, under γ and UV irradiation, and Fenton-like conditions. Here, we report the synthesis of a series of new hydrophilic PADs and the evaluation of their radioprotective efficacy in cell culture. Using a cell-based fluorescent assay, we show that some of these compounds have a pronounced ability to prevent cell death caused by radiation and to allow the subsequent resumption of proliferation. Thus, PADs may be considered as a novel class of radioprotective agents.
Laboratory of Functional Chemo-Systems, UMR 7199, Université de Strasbourg, and Centre régional de Lutte contre le Cancer Paul Strauss 3, rue de la Porte de l’Hôpital, 74, route du Rhin 67401 Illkirch-Graffenstaden, France.
Antoine
A
Le Roux
Stéphane
S
Meunier
Thierry
T
Le Gall
Jean-Marc
JM
Denis
Pierre
P
Bischoff
Alain
A
Wagner
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D057166:High-Throughput Screening Assays; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010648:Phenylacetates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014466:Ultraviolet Rays
D002264:Carboxylic Acids; D007783:Lactones; D010648:Phenylacetates; D011837:Radiation-Protective Agents; C464564:norbadione A; D015107:4-Butyrolactone; C492654:pulvinic acid