Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection.
Data from limited autopsies of human patients demonstrate that pathological changes in EV71-infected fatal cases are principally characterized by clear inflammatory lesions in different parts of the CNS; nearly identical changes were found in murine, cynomolgus and rhesus monkey studies which provide evidence of using animal models to investigate the mechanisms of EV71 pathogenesis. Our work uses neonatal rhesus monkeys to investigate a possible model of EV71 pathogenesis and concludes that this model could be applied to provide objective indicators which include clinical manifestations, virus dynamic distribution and pathological changes for observation and evaluation in interpreting the complete process of EV71 infection. This induced systemic infection and other collected indicators in neonatal monkeys could be repeated; the transmission appears to involve infecting new monkeys by contact with feces of infected animals. All data presented suggest that the neonatal rhesus monkey model could shed light on EV71 infection process and pathogenesis.
Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, 379 Jiaoling Road, Kunming, Yunnan, PR China.
Longding
L
Liu
Hongling
H
Zhao
Ying
Y
Zhang
Jingjing
J
Wang
Yanchun
Y
Che
Chenghong
C
Dong
Xuemei
X
Zhang
Ruixiong
R
Na
Haijing
H
Shi
Li
L
Jiang
Lichun
L
Wang
Zhongping
Z
Xie
Pingfang
P
Cui
Xiangling
X
Xiong
Yun
Y
Liao
Shudong
S
Zhao
Jiahong
J
Gao
Donghong
D
Tang
Qihan
Q
Li
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D029821:Enterovirus A, Human / Q000472:pathogenicity*; D004769:Enterovirus Infections / Q000473:pathology* / Q000635:transmission / Q000821:virology*; D005243:Feces / Q000821:virology; D006801:Humans; D008253:Macaca mulatta / Q000821:virology*