Structured exercise does not stabilize cognitive function in individuals with mild cognitive impairment residing in a structured living facility.
Exercise has been shown to have positive effects on the brain and cognition in healthy older adults, though no study has directly examined possible cognitive benefits of formal exercise programs in persons with mild cognitive impairment (MCI) living in structured facilities. Thirty-one participants completed neuropsychological testing and measures of cardiovascular fitness at baseline and after 6 months of a structured exercise program that included aerobic and resistance training. While exercise improved cardiovascular fitness in persons with MCI, there was no improvement in cognitive function. Rather, MCI patients in this sample declined in performance on several tests sensitive to Alzheimer's disease. Examined in the context of past work, it appears exercise may be beneficial prior to the onset of MCI, though less helpful after its onset.
Department of Psychology, Kent State University, Kent Hall, Kent, Ohio 44242, USA.
Lindsay A
LA
Miller
Mary Beth
MB
Spitznagel
Susan
S
Busko
Vanessa
V
Potter
Judi
J
Juvancic-Heltzel
Nancy
N
Istenes
Ellen
E
Glickman
John
J
Gunstad
D000368:Aged; D000369:Aged, 80 and over; D040561:Assisted Living Facilities; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D015444:Exercise / Q000502:physiology / Q000523:psychology; D005081:Exercise Therapy / Q000379:methods* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D010809:Physical Fitness / Q000502:physiology / Q000523:psychology; D055070:Resistance Training / Q000379:methods; D017211:Treatment Failure
JAMA. 1994 Feb 16;271(7):519-24
8301766
Am J Alzheimers Dis Other Demen. 2007 Oct-Nov;22(5):389-97
17959874
J Neuropsychiatry Clin Neurosci. 2008 Summer;20(3):327-30
18806236
Neurology. 2000 Dec 12;55(11):1621-6
11113214
J Gerontol. 1974 Mar;29(2):157-61
4811950
Age Ageing. 1993 Jan;22(1):11-5
8438659
Behav Res Methods. 2007 May;39(2):175-91
17695343
J Clin Epidemiol. 2008 Aug;61(8):827-31
18468855
Med Sci Sports Exerc. 2007 Aug;39(8):1435-45
17762378
JAMA. 2008 Sep 3;300(9):1027-37
18768414
Neurobiol Aging. 2005 Dec;26 Suppl 1:124-7
16213062
J Gerontol A Biol Sci Med Sci. 2003 Feb;58(2):176-80
12586857
Arch Neurol. 2010 Jan;67(1):71-9
20065132
J Am Geriatr Soc. 1988 Jan;36(1):29-33
3335727
Aging Ment Health. 2008 Jan;12(1):72-80
18297481
J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1166-70
17167157
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2009 Mar;16(2):203-18
18923961
J Am Geriatr Soc. 1996 May;44(5):507-12
8617897
Psychol Sci. 2003 Mar;14(2):125-30
12661673
J Am Med Dir Assoc. 2009 May;10(4):271-6
19426944
Dement Geriatr Cogn Disord. 2005;19(5-6):383-9
15802914
Geriatr Nurs. 2008 Nov-Dec;29(6):384-91
19064136
Alzheimer Dis Assoc Disord. 2008 Jan-Mar;22(1):39-46
18317245
Int J Sports Med. 2008 Oct;29(10):845-50
18401810
CNS Spectr. 2008 Jan;13(1):45-53
18204414
J Clin Psychiatry. 1987 Aug;48(8):314-8
3611032
J Am Geriatr Soc. 2007 Feb;55(2):158-65
17302650
Neurology. 1993 Nov;43(11):2412-4
8232972