Stressed and depressed? Check your GDNF for epigenetic repression.
Some adults fail to adapt to chronic stress, developing symptoms of depression and anxiety. In this issue of Neuron, Uchida and colleagues link maladaptive stress responses to GDNF through a comprehensive investigation of the neurotrophic factor's regulation. Further, this study is an excellent example for investigators interested in neuroepigenetics research.
Department of Metabolism & Aging, Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33459, USA. cmiller@scripps.edu
Courtney A
CA
Miller
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