Pyroptosis: macrophage suicide exposes hidden invaders.
Caspase-1 plays a key role in host defense through its dual function in inducing a pro-inflammatory cell death termed pyroptosis and in promoting the secretion of pro-inflammatory cytokines. A new study now highlights the specific importance of pyroptosis in resistance to intracellular pathogens.
Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. igor.brodsky@yale.edu
Igor E
IE
Brodsky
Ruslan
R
Medzhitov
D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D020170:Caspase 1 / Q000235:genetics / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005408:Flagellin / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000382:microbiology* / Q000502:physiology*
D016207:Cytokines; D005408:Flagellin; D020170:Caspase 1