[Effect of L-arginine and aminoguanidine on morphological characteristics of the lymphocyte plasma membranes during experimental diabetes mellitus].
Diameter, the surface area of lymphocytes and their nuclea as well as the reserve potential and regulatory properties of lymphocytes membranes in control rats, in rats with experimental diabetes mellitus before and after administration of L-arginine and aminoguanidine were investigated. Significant difference in size and the membrane fund of lymphocytes in animals with experimental diabetes mellitus was detected. In control lymphocytes, the membrane fund was 70% while during diabetes mellitus it was 40%. Such a difference might be one of the reasons of changes in properties and functional state of lymphocytes in diabetes. Administration of L-arginine and aminoguanidine to diabetic animals caused positive effect: the volume of lymphocytes diminished and the regulatory membrane properties of these cells became better.
I V
IV
Brodiak
A R
AR
Hnatush
N O
NO
Sybirna
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D018929:Cell Culture Techniques; D002462:Cell Membrane / Q000187:drug effects* / Q000502:physiology; D048429:Cell Size; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D006146:Guanidines / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D006146:Guanidines; D001120:Arginine; C004479:pimagedine