Cardiac sodium-calcium exchange research New directions.
The sarcolemmal Na(+)-Ca(2+) exchanger is the dominant myocardial Ca(2+) efflux mechanism and has a central role in the regulation of contractility. Physiologic and molecular advances in Na(+)-Ca(2+) exchange research have led a resurgence of interest in this system. Molecular cloning of the exchanger has recently been accomplished, and information on the molecular structure and reaction mechanism is forthcoming.
Cardiovascular Research Laboratory, MacDonald Research Building, Room 3645, UCLA School of Medicine, Los Angeles, CA 90024-1760, USA.
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Philipson