Malaria crystalloids: specialized structures for parasite transmission?
Malaria parasites possess many unique subcellular structures and organelles that are essential for the successful completion of the complex life cycle of Plasmodium in the vertebrate host and mosquito vector. Among these are the crystalloids: transient structures whose presence is restricted to the mosquito-specific ookinete and young oocyst stages of the parasite. Nearly five decades after they were first described, the crystalloids are back in the spotlight, with recent discoveries pointing to an important role in protein trafficking and sporozoite transmission that could be exploited as new targets for control of malaria transmission.
Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Johannes.Dessens@lshtm.ac.uk
Johannes T
JT
Dessens
Sadia
S
Saeed
Annie Z
AZ
Tremp
Victoria
V
Carter
D000818:Animals; D022083:Cytoplasmic Structures / Q000378:metabolism*; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D008288:Malaria / Q000469:parasitology* / Q000635:transmission*; D033661:Oocysts / Q000254:growth & development / Q000378:metabolism; D010961:Plasmodium / Q000472:pathogenicity / Q000502:physiology*; D010962:Plasmodium berghei / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D015800:Protozoan Proteins / Q000378:metabolism; D034101:Sporozoites / Q000254:growth & development
D015800:Protozoan Proteins
J Exp Med. 2004 Jun 7;199(11):1533-44
15184503
Ann Trop Med Parasitol. 1974 Sep;68(3):283-90
4614723
Nature. 2002 Oct 3;419(6906):537-42
12368870
J Parasitol. 2004 Oct;90(5):1062-71
15562607
J Protozool. 1973 Feb;20(1):73-80
4632265
Eur J Biochem. 2000 Sep;267(18):5751-7
10971586
Cell. 2005 Jun 3;121(5):675-87
15935755
Curr Opin Infect Dis. 2007 Oct;20(5):476-81
17762780
Exp Parasitol. 2006 Apr;112(4):263-8
16388802
Lancet. 2005 Apr 23-29;365(9469):1487-98
15850634
Parasitol Res. 1987;73(6):500-6
3321042
Int J Parasitol. 2008 Mar;38(3-4):327-40
17950739
Mil Med. 1969 Sep;134(10):916-21
4987065
Trends Parasitol. 2004 Mar;20(3):102-8
16482225
Mol Biochem Parasitol. 2002 Apr 30;121(1):11-20
11985859
Mol Biochem Parasitol. 2010 Mar;170(1):49-53
19932717
J Biol Chem. 2009 May 22;284(21):14537-46
19304662
Mol Biochem Parasitol. 2009 Jan;163(1):1-7
18848846
Mol Cell Proteomics. 2009 Sep;8(9):2102-18
19494339
J Parasitol. 1976 Jun;62(3):366-71
778372
Trans R Soc Trop Med Hyg. 1962 Mar;56:116-20
13897014
Trans R Soc Trop Med Hyg. 1969;63(2):187-94
5794450
Mol Microbiol. 2008 Jun;68(6):1560-9
18452513
Mol Microbiol. 2008 Oct;70(1):209-20
18761621
PLoS Pathog. 2007 Mar;3(3):e30
17335349
Parasitology. 1985 Oct;91 ( Pt 2):227-44
3906519
Mol Microbiol. 2002 Sep;45(6):1473-84
12354219