Ultrasound biomicroscopic imaging of iris melanoma: a clinicopathologic study.
OBJECTIVE
To demonstrate the correlation of ultrasound biomicroscopy (UBM) features of iris melanoma with histopathology.


METHODS
Retrospective analysis of medical records.


METHODS
The medical records of patients that underwent surgery for iris melanoma at the Princess Margaret Hospital, University of Toronto, from June 1990 to October 1998 were reviewed. The clinical features, as well as the UBM findings prior to surgical intervention, were evaluated. The anatomic features noted on UBM were correlated with histopathologic features seen in the surgical specimens.


RESULTS
Fourteen cases met the inclusion criteria and were included in the final analysis. The ultrasound acoustic characteristics showed a broad spectrum of findings among iris melanomas. Tumor acoustic parameters correlated well with histologic features, including tumor vascularity, surface plaque, extrascleral extension, ciliary body involvement, and integrity of iris pigment epithelium.


CONCLUSIONS
UBM is a useful imaging technique for the in vivo assessment of primary iris melanoma and can provide detailed imaging of the tumor's interface with the angle structures. The preoperative assessment of these tumors by UBM may aid the surgeon in choosing the most appropriate technique to ensure total removal.
Princess Margaret Hospital, Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada. gpgiuliari@gmail.com
G Paolo
GP
Giuliari
Hugh D
HD
McGowan
Charles J
CJ
Pavlin
J Godfrey
JG
Heathcote
E Rand
ER
Simpson
D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015811:Iris Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D033401:Microscopy, Acoustic; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012189:Retrospective Studies; D015422:Scleral Diseases / Q000473:pathology; D055815:Young Adult