Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy.
Cardiac hypertrophy is a stereotypic response of the heart to increased workload. The nature of the workload increase may vary depending on the stimulus (repetitive, chronic, pressure, or volume overload). If the heart fully adapts to the new loading condition, the hypertrophic response is considered physiological. If the hypertrophic response is associated with the ultimate development of contractile dysfunction and heart failure, the response is considered pathological. Although divergent signalling mechanisms may lead to these distinct patterns of hypertrophy, there is some overlap. Given the close relationship between workload and energy demand, any form of cardiac hypertrophy will impact the energy generation by mitochondria, which are the key organelles for cellular ATP production. Significant changes in the expression of nuclear and mitochondrially encoded transcripts that impact mitochondrial function as well as altered mitochondrial proteome composition and mitochondrial energetics have been described in various forms of cardiac hypertrophy. Here, we review mitochondrial alterations in pathological and physiological hypertrophy. We suggest that mitochondrial adaptations to pathological and physiological hypertrophy are distinct, and we shall review potential mechanisms that might account for these differences.
Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, 15 North 2030 East, Bldg. 533, Rm. 3110B, Salt Lake City, UT 84112, USA. dale.abel@hmbg.utah.edu
E Dale
ED
Abel
Torsten
T
Doenst
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006321:Heart / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E678-85
18593850
Ann Clin Lab Sci. 2006 Winter;36(1):88-95
16501242
Biochim Biophys Acta. 2010 Mar;1801(3):311-9
19818871
J Lipid Res. 2009 Aug;50(8):1600-8
19001357
Physiology (Bethesda). 2006 Aug;21:250-8
16868314
Biophys J. 2010 May 19;98(10):2063-71
20483313
Circ Res. 2010 Apr 16;106(7):1253-64
20185797
Pharmacol Rep. 2009 Jan-Feb;61(1):131-8
19307701
Genomics. 2006 Oct;88(4):480-8
16781840
Thorac Cardiovasc Surg. 2003 Aug;51(4):211-5
14502458
J Clin Invest. 2005 Aug;115(8):2108-18
16075055
Cardiovasc Res. 1998 Jul;39(1):60-76
9764190
Cell Metab. 2009 Jun;9(6):512-24
19490906
J Mol Cell Cardiol. 2008 Apr;44(4):694-700
18328500
Cardiovasc Res. 2008 Oct 1;80(1):30-9
18710878
Cardiovasc Res. 2010 Jan 15;85(2):376-84
19843514
Res Vet Sci. 2003 Jun;74(3):219-26
12726740
Sports Med. 2008;38(1):69-90
18081368
Mol Endocrinol. 2008 Nov;22(11):2531-43
18801929
Antioxid Redox Signal. 2010 Oct 1;13(7):1011-22
20406135
Heart. 2003 Dec;89(12):1455-61
14617564
Circulation. 2001 Mar 20;103(11):1570-6
11257087
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15565-70
20713697
J Mol Cell Cardiol. 2009 Feb;46(2):130-6
18845155
J Mol Cell Cardiol. 1983 Apr;15(4):221-32
6308271
J Lipid Res. 2007 Jul;48(7):1559-70
17426348
Proteomics. 2008 Jun;8(12):2556-72
18563753
Am J Physiol. 1994 Aug;267(2 Pt 2):H556-62
8067410
Mitochondrion. 2001 Aug;1(2):151-9
16120275
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10086-91
16775082
Cardiovasc Res. 2009 Feb 15;81(3):420-8
18854380
J Appl Physiol (1985). 2003 Feb;94(2):752-63
12531914
J Biol Chem. 2008 Sep 26;283(39):26484-9
18625706
Physiol Genomics. 2005 May 11;21(3):314-23
15728335
Circulation. 2007 Jun 26;115(25):3213-23
17592090
Heart Fail Rev. 2002 Apr;7(2):161-73
11988640
Cardiovasc Res. 2001 Oct;52(1):103-10
11557238
Nat Med. 2007 Mar;13(3):324-31
17322895
J Clin Invest. 2005 Mar;115(3):547-55
15765136
Nat Rev Mol Cell Biol. 2006 Aug;7(8):589-600
16936699
Circ Res. 2006 Jan 6;98(1):15-24
16397154
Cell Calcium. 2009 Jun;45(6):643-50
19368971
Basic Res Cardiol. 2006 Jan;101(1):17-26
16136293
Cell Mol Life Sci. 2008 Aug;65(16):2493-506
18425414
Hypertension. 2010 Sep;56(3):412-21
20696994
Comp Biochem Physiol A Mol Integr Physiol. 2003 Aug;135(4):499-513
12890541
Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H140-8
16920812
Cardiovasc Res. 2010 Jun 1;86(3):461-70
20035032
J Clin Invest. 2005 Aug;115(8):2059-64
16075047
J Physiol. 2010 Sep 15;588(Pt 18):3551-66
20643772
J Am Coll Cardiol. 2009 Jul 28;54(5):375-85
19628111
Am J Physiol. 1994 Aug;267(2 Pt 2):H742-50
8067430
Cardiovasc Res. 2009 Feb 15;81(3):449-56
18854381
Cardiology. 2002;97(4):203-9
12145475
Circ Res. 2001 May 25;88(10):1088-94
11375280
FEBS J. 2005 Jun;272(11):2684-95
15943803
Biochim Biophys Acta. 2000 Nov 15;1502(3):330-6
11068176
J Am Coll Cardiol. 2000 Oct;36(4):1378-85
11028498
J Mol Cell Cardiol. 1998 Sep;30(9):1757-62
9769231
Physiol Rev. 2010 Jan;90(1):207-58
20086077
FASEB J. 2004 Nov;18(14):1692-700
15522914
J Physiol. 2003 Sep 1;551(Pt 2):491-501
12824444
Eur J Appl Physiol. 2009 Dec;107(6):697-706
19730878
J Clin Invest. 1975 Jul;56(1):56-64
124746
J Thorac Cardiovasc Surg. 2010 Jun;139(6):1609-17
20038480
Am J Physiol Cell Physiol. 2007 Jan;292(1):C33-44
16899548
Hypertension. 2009 Apr;53(4):701-7
19255362
J Clin Hypertens (Greenwich). 2004 Oct;6(10 Suppl 2):14-7
15470294
Cardiology. 1999;92 Suppl 1:3-6; discussion 7-9, 20-1
10652966
J Am Coll Cardiol. 2009 Oct 27;54(18):1637-46
19850204
Circulation. 2006 Jun 6;113(22):2579-88
16735673
Eur Heart J. 2005 Sep;26(17):1790-6
15860517
Biochim Biophys Acta. 2010 Mar;1801(3):266-71
19782153
J Physiol. 2006 Jul 1;574(Pt 1):33-9
16709637
Sports Med. 2004;34(14):967-81
15571428
Circ Res. 2010 May 14;106(9):1541-8
20339121
Curr Hypertens Rep. 2004 Dec;6(6):430-5
15527686
Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1055-63
15105170
Endocr Rev. 2003 Feb;24(1):78-90
12588810
J Am Coll Cardiol. 2009 Nov 3;54(19):1747-62
19874988
J Clin Invest. 2008 Nov;118(11):3588-97
18830415
J Clin Invest. 2000 Jun;105(12):1723-30
10862787
J Mol Cell Cardiol. 2009 Jun;46(6):952-9
19452634
J Appl Physiol (1985). 1987 Mar;62(3):1097-110
2952629
Cardiology. 1998 Oct;90(2):101-9
9778546
Circulation. 2007 Apr 17;115(15):2033-41
17404155
Cardiovasc Res. 2001 Jan;49(1):17-26
11121792
Cardiovasc Res. 2010 Nov 1;88(2):229-40
20639213
Clin Exp Pharmacol Physiol. 2007 Apr;34(4):255-62
17324134
Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S268-9
9072385
Am J Physiol. 1995 Jan;268(1 Pt 2):R33-9
7840336
Mol Cell Biochem. 1996 Jun 21;159(2):139-48
8858564
Cardiovasc Res. 1971 Oct;5(4):444-50
4258553
Cell Metab. 2007 Oct;6(4):294-306
17908558
Hypertens Res. 2003 Oct;26(10):829-37
14621187
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22
17609368
Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E629-36
12759223
Heart Fail Clin. 2006 Oct;2(4):435-42
17448430
J Mol Cell Cardiol. 2009 Nov;47(5):664-75
19744489
Acta Physiol (Oxf). 2009 May;196(1):37-53
19239414
Circulation. 2002 Jul 30;106(5):606-12
12147544
Circulation. 2007 Jan 23;115(3):333-44
17210842
J Mol Cell Cardiol. 2009 Jun;46(6):910-8
19249310
Circulation. 2009 Mar 10;119(9):1272-83
19237663
Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H541-8
12714322
Circ Heart Fail. 2010 May;3(3):420-30
20176713
Ann Thorac Surg. 2005 Apr;79(4):1445-53
15797108
Mol Cell Biochem. 2008 Apr;311(1-2):215-24
18278440