Second trimester pregnancy termination with 400 μg vaginal misoprostol: efficacy and safety.
The present study was designed to evaluate the efficacy and safety of misoprostol (400 μg) given intravaginally repeated at 6 hourly intervals for a maximum of 6 doses for second-trimester pregnancy terminations. The study was conducted on women who had to undergo pregnancy termination between 13 and 26 weeks of gestation for various indications but mainly intrauterine death over a period of 2 years. A standard regime of 400 μg of misoprostol 6 hourly intravaginally was given until a maximum of 6 doses. Sixty women underwent second trimester terminations. The mean induction abortion interval was 11.8 h. The success rate at the end of 48 h was 96.6%. Side-effects were in the form of incomplete abortion, excessive blood loss, and fever. No patient had a uterus rupture. Intravaginal misoprostol 400 μg given 6 hourly seems to be an effective, safe, and acceptable method for second trimester pregnancy terminations.
Department of Obstetrics & Gynaecology, Era's Lucknow Medical College, Lucknow, India. shipra.kunwar@gmail.com
Shipra
S
Kunwar
Pradip K
PK
Saha
Poonam
P
Goel
Anju
A
Huria
Rimpi
R
Tandon
Alka
A
Sehgal
D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D005313:Fetal Death; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol