Modification of fatty acids composition in erythrocytes lipids in arterial hypertension associated with dyslipidemia.
BACKGROUND
Modification of fatty acids (FA) composition in erythrocytes lipids as an early indicator of the development of arterial hypertension (AH) and lipid disorders.


METHODS
We included 34 patients with arterial hypertension and 11 healthy individuals. Each patient was examined the lipid composition of serum. From erythrocytes by gas chromatography were identified fatty acids. The quantitative composition of the erythrocyte lipids FA in patients with AH presented with saturated and polyunsaturated monoenic acids with carbon chain lengths from C12 to C22.


RESULTS
In all hypertensive patients is disturbed lipid FA composition of erythrocytes. The patients with a normal level of serum lipids revealed deficiency of polyunsaturated acids n6-linoleic (18:2 n6), arachidonic (20:4 n6), dokozatetraenic 14.4% (22:4 n6). The patients with dislipidemia installed more profound restructuring of the lipid matrix of the membrane of erythrocytes. A decrease in polyunsaturated fatty acids family n3: dokozapentaenovoy (22:5 n3), docosahexaenoic PUFA (22:6 n3), the total value of n3 PUFA in 1,3 times was revealed.


CONCLUSIONS
Thus, modification of erythrocyte FA are fairly subtle indicator of pathology of lipid metabolism, which manifest themselves much earlier than changes in the lipoprotein of blood plasma.
Vladivostok Branch of the Far Eastern Center of Physiology and Pathology of Respiration of SB RAMN-Institute of Medical Climatology and Rehabilitative Treatment, Russia.
Tatyana P
TP
Novgorodtseva
Tatyana A
TA
Kantur
Yulia K
YK
Karaman
Marina V
MV
Antonyuk
Natalia V
NV
Zhukova
D016022:Case-Control Studies; D050171:Dyslipidemias / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D004912:Erythrocytes / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D008055:Lipids / Q000097:blood; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008875:Middle Aged
D005227:Fatty Acids; D008055:Lipids; D008563:Membrane Lipids
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