Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C.
Recently, a IL28B (rs 12979860) gene polymorphism was identified as a predictor for response to hepatitis C virus-specific treatment in human immunodeficiency virus (HIV)-uninfected and -infected patients with chronic hepatitis C. In an analysis of HIV-infected patients with acute hepatitis C, we found that the IL28B genotype was associated with serum levels of hepatitis C virus RNA, g-GT, and CD4 cell count. In contrast to HIV-infected patients with chronic hepatitis C, the IL28B genotype was not significantly associated with treatment response rates in patients with acute hepatitis C. Thus, effects of the IL28B single-nucleotide polymorphism may differ in HIV-infected patients with chronic and acute hepatitis C.
Department of Internal Medicine I, University of Bonn, Bonn, Germany. jacob.nattermann@ukb.uni-bonn.de
Jacob
J
Nattermann
Martin
M
Vogel
Hans Dieter
HD
Nischalke
Mark
M
Danta
Stefan
S
Mauss
Hans-Jörg
HJ
Stellbrink
Axel
A
Baumgarten
Christoph
C
Mayr
Raffaele
R
Bruno
Cristina
C
Tural
Gerd
G
Klausen
Bonaventura
B
Clotet
Uwe
U
Naumann
Thomas
T
Lutz
Michael
M
Rausch
Knud
K
Schewe
Bernhard
B
Bienek
Georg
G
Haerter
Tilman
T
Sauerbruch
Juergen K
JK
Rockstroh
Ulrich
U
Spengler
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000235:genetics* / Q000821:virology*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012367:RNA, Viral / Q000032:analysis; D012044:Regression Analysis; D016896:Treatment Outcome; D000095022:Interferon Lambda
D007372:Interferons; D007378:Interleukins; D012367:RNA, Viral; C000624353:interferon-lambda, human; D000095022:Interferon Lambda
Gastroenterology. 2010 Aug;139(2):499-509
20434452
Lancet Infect Dis. 2004 Jul;4(7):437-44
15219554
Nat Genet. 2009 Oct;41(10):1100-4
19749758
Nature. 2009 Sep 17;461(7262):399-401
19684573
Gastroenterology. 2006 Dec;131(6):1887-98
17087946
N Engl J Med. 2001 Nov 15;345(20):1452-7
11794193
AIDS. 2010 May 15;24(8):F23-9
20389235
Antivir Ther. 2006;11(8):1097-101
17302380
Proc Natl Acad Sci U S A. 2008 May 13;105(19):7034-9
18467494
Gastroenterology. 2010 Apr;138(4):1338-45, 1345.e1-7
20060832
Gastroenterology. 2010 Jun;138(7):2307-14
20176026
Ann Intern Med. 2002 Feb 19;136(4):288-92
11848726
HIV Med. 2008 Feb;9(2):82-8
18257771
Nat Immunol. 2003 Jan;4(1):69-77
12483210
Nat Genet. 2009 Oct;41(10):1105-9
19749757