Clinical, genetic, and pathological features of male pseudohermaphroditism in dog.
Male pseudohermaphroditism is a sex differentiation disorder in which the gonads are testes and the genital ducts are incompletely masculinized. An 8 years old dog with normal male karyotype was referred for examination of external genitalia abnormalities. Adjacent to the vulva subcutaneous undescended testes were observed. The histology of the gonads revealed a Leydig and Sertoli cell neoplasia. The contemporaneous presence of testicular tissue, vulva, male karyotype were compatible with a male pseudohermaphrodite (MPH) condition.
Faculty of Veterinary Medicine, Department of Animal Health, Parma, Italy. enrico.bigliardi@unipr.it
Enrico
E
Bigliardi
Pietro
P
Parma
Paolo
P
Peressotti
Lisa
L
De Lorenzi
Peter
P
Wohlsein
Benedetta
B
Passeri
Stefano
S
Jottini
Anna Maria
AM
Cantoni
D000818:Animals; D058490:Disorder of Sex Development, 46,XY / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D024282:Genes, sry / Q000235:genetics; D006066:Gonads / Q000473:pathology; D007984:Leydig Cell Tumor / Q000473:pathology / Q000662:veterinary*; D008297:Male; D013736:Testicular Neoplasms / Q000473:pathology / Q000662:veterinary*; D013737:Testis / Q000473:pathology
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