Efficient one-pot three-component synthesis of fused pyridine derivatives in ionic liquid.
An efficient one-pot synthesis of fused pyridine derivatives (including pyrazolo[3,4-b]pyridine and pyrido[2,3-d]pyrimidine) by three-component reaction of aldehyde, acyl acetonitrile, and electron-rich amino heterocycles (including aminopyrazole and aminouracils) in ionic liquid is reported. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, and convenient operation.
Soochow University, Suzhou, PR China.
Zhibin
Z
Huang
Yu
Y
Hu
Yao
Y
Zhou
Daqing
D
Shi
D007477:Ions; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D011725:Pyridines / Q000737:chemistry*
D007477:Ions; D011725:Pyridines; C023666:pyridine