Collapsing glomerulopathy in a patient with mixed connective tissue disease.
Collapsing glomerulopathy (CG) is a distinct clinicopathological entity characterized by glomerular capillary collapse, podocyte proliferation, diffuse mesangial sclerosis, and podocyte maturation arrest. Initially noted primarily in HIV infected patients, a number of other diseases have now been associated with CG. Mixed connective tissue disease (MCTD) is a disease with overlapping features of systemic lupus erythematosus, progressive systemic sclerosis, and polymyositis. It was originally thought that renal involvement was a rare complication of MCTD. However, over the years, it has become clearer that renal involvement, although not always clinically apparent, is frequent. In this report we present a patient with MCTD who developed CG.
Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL, USA. srifkin@health.usf.edu
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Rifkin
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H
Gutta
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Nair
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McFarren
D E
DE
Wheeler
D001706:Biopsy; D002196:Capillaries / Q000473:pathology; D049109:Cell Proliferation; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007678:Kidney Glomerulus / Q000098:blood supply / Q000473:pathology*; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology / Q000628:therapy; D050199:Podocytes / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D006435:Renal Dialysis; D012598:Sclerosis / Q000209:etiology / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D011239:Prednisolone