Energy matters: mitochondrial proteomics for biomedicine.
This review compiles results of medical relevance from mitochondrial proteomics, grouped either according to the type of disease - genetic or degenerative - or to the involved mechanism - oxidative stress or apoptosis. The findings are commented in the light of our current understanding of uniformity/variability in cell responses to different stimuli. Specificities in the conceptual and technical approaches to human mitochondrial proteomics are also outlined.
Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano, Milano, Italy. elisabetta.gianazza@unimi.it
Elisabetta
E
Gianazza
Ivano
I
Eberini
Cristina
C
Sensi
Maria
M
Barile
Lodovica
L
Vergani
Maria Antonietta
MA
Vanoni
D000818:Animals; D030342:Genetic Diseases, Inborn / Q000378:metabolism*; D006801:Humans; D024101:Mitochondrial Proteins / Q000032:analysis*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
D024101:Mitochondrial Proteins