Clinical significance of T-cadherin tissue expression in patients with bladder transitional cell carcinoma.
OBJECTIVE
To investigate the clinical significance of T-cadherin (T-cad) tissue expression in patients with bladder transitional cell carcinoma (TCC).


METHODS
T-cad expression in 113 bladder TCC specimens and 37 normal controls were examined by immunohistochemical staining, and the results were correlated with clinicopathologic parameters. The χ(2) test, Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazard model were used for statistical analysis.


RESULTS
T-cad expression in bladder TCC samples was lower than in the controls. Decreased T-cad expression was correlated with advanced stage (p = 0.0027), high grade (p = 0.0078), large tumor size (p = 0.0262), and tumor relapse (p = 0.0293), but no association was found among T-cad expression and age (p = 0.1265), gender (p = 0.4236), tumor number (p = 0.0595) or tumor shape (p = 0.1779). Moreover, decreased T-cad expression was significantly associated with poor overall survival (p = 0.0168), even though it is not an independent prognostic marker (p = 0.2005).


CONCLUSIONS
Decreased T-cad expression in tumor tissues is closely associated with malignancy in bladder TCC.
Department of Urology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi, Tianjin, PR China.
YingLi
Y
Lin
Guang
G
Sun
XiaoQiang
X
Liu
YeGang
Y
Chen
ChunTing
C
Zhang
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000096:biosynthesis*; D002295:Carcinoma, Transitional Cell / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
D014408:Biomarkers, Tumor; D015820:Cadherins; C099972:H-cadherin