Effect of antibodies to glutamate on retention of conditioned passive avoidance response in rats with ischemic injury of the prefrontal cortex.
Experiments were performed on rats with bilateral photothrombosis of vessels in the prefrontal cortex. Intranasal administration of antibodies to glutamate (1 h after ischemia of the brain cortex) improved retention of conditioned passive avoidance response, which was elicited before ischemic damage. The content of antibodies to glutamate in the serum of rats increased significantly on day 8 after bilateral photochemical thrombosis of vessels in the prefrontal cortex compared to that in the control.
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. romanova@mail.ru
G A
GA
Romanova
F M
FM
Shakova
V Yu
VY
Gorbatov
Yu N
YN
Kvashennikova
T V
TV
Davydova
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D002545:Brain Ischemia / Q000188:drug therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D018698:Glutamic Acid / Q000276:immunology*; D008297:Male; D010777:Photochemistry / Q000379:methods; D017397:Prefrontal Cortex / Q000503:physiopathology*; D051381:Rats; D012395:Rose Bengal; D018709:Statistics, Nonparametric
D000906:Antibodies; D012395:Rose Bengal; D018698:Glutamic Acid