c-Maf suppresses human T-cell leukemia virus type 1 Tax by competing for CREB-binding protein.
Latent infection of human T-cell leukemia virus type 1 (HTLV-1) is considered to be preferentially associated with CCR4(+) CD4(+) T cells. Here we report that c-Maf, one of the critical transcription factors for Th2 differentiation, suppresses the transcriptional activity of HTLV-1 Tax by competing for CREB-binding protein. Notably, c-maf expression is selectively induced in a fraction of CCR4(+) CD4(+) T cells upon activation. Furthermore, c-Maf significantly decreases Tax-induced HTLV-1 envelope gp46 gene expression from an infectious HTLV-1 molecular clone and tax expression in a cell-free HTLV-1 infection system. Collectively, c-Maf may play a role in latent infection of HTLV-1 in CCR4(+) CD4(+) T cells by negatively regulating Tax activity.
Department of Microbiology, Kinki University Faculty of Medicine, Osaka, Japan. hieshima@med.kindai.ac.jp
Kunio
K
Hieshima
Daisuke
D
Nagakubo
Akiko
A
Shigeta
Yuetsu
Y
Tanaka
Hiroo
H
Hoshino
Kunihiro
K
Tsukasaki
Yasuaki
Y
Yamada
Osamu
O
Yoshie
D015153:Blotting, Western; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000821:virology; D050882:CREB-Binding Protein / Q000235:genetics / Q000378:metabolism*; D002472:Cell Transformation, Viral; D015686:Gene Products, env / Q000235:genetics / Q000378:metabolism; D016356:Gene Products, tax / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015490:HTLV-I Infections / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019169:Jurkat Cells; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000378:metabolism / Q000821:virology; D008156:Luciferases / Q000378:metabolism; D011401:Promoter Regions, Genetic; D051257:Proto-Oncogene Proteins c-maf / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D054398:Receptors, CCR4 / Q000235:genetics / Q000378:metabolism; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018418:Th2 Cells; D015533:Transcriptional Activation; D014771:Virion
C515354:CCR4 protein, human; D015686:Gene Products, env; D016356:Gene Products, tax; C495607:MAF protein, human; D051257:Proto-Oncogene Proteins c-maf; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D054398:Receptors, CCR4; D015682:Retroviridae Proteins, Oncogenic; C055266:gp46 protein, Human T-cell leukemia virus type I; D008156:Luciferases; D050882:CREB-Binding Protein; C494363:CREBBP protein, human