[Effect of the antiviral drug Ingaviruin on intracellular transformations and import into the nucleus of influenza A virus nucleocapsid protein].
The paper presents the results of studying the effect of the antiviral drug Ingavirin on different stages of intracellular transformations of influenza A virus nucleocapsid protein (NP). Ingavirin 400-1000 microg/ml has been found to impair the biogenesis of influenza virus NP, to lower the efficiency of formation of conformationally mature compact NP oligomers, and to retard the migration of newly-synthesized NP from the cytoplasm to the nucleus. It is shown that there is an association of tritium-labeled Ingavirin with the nuclear membranes of MDCK cells. The investigations of the mechanisms of antiviral activity of Ingavirin are not only important for the characterization of this drug, but also promote the detection of potential targets to design novel antiviral agents.
N P
NP
Semenova
E N
EN
Prokudina
D K
DK
Livov
V E
VE
Nebol'sin
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002208:Caproates; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004285:Dogs; D007093:Imidazoles / Q000494:pharmacology*; D053123:Influenza A Virus, H3N8 Subtype / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D019590:Nucleocapsid Proteins / Q000187:drug effects / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000821:virology*; D021381:Protein Transport / Q000187:drug effects; D019065:Virus Assembly / Q000187:drug effects
D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D007093:Imidazoles; D019590:Nucleocapsid Proteins; C539419:pentanedioic acid imidazolyl ethanamide