[Interstrain differences in testicular responses to hCG: effects of a female exposition].
It is known that among many animal species, including laboratory mice, a short-time exposition to a female causes activation of the pituitary-testicular axis in males, which then rapidly decreases. Effects of a prolonged female exposition on the testicular testosterone output in response to hCG injections were investigated in adult males of two inbred mice strains CBA/Lac and PT. The males of both genotypes kept with females for 5 days were injected subcutaneously with 10 IU of hCG 120 minutes before decapitation. Males of the same genotype and similar age keeping alone were served as control. The serum testosterone concentration and its testicular content were measured with immune-enzyme assay. It has been shown that the hCG increased the testosterone concentration and its testicular content in control males of both strains, but the testosterone output was expressed more significantly in PT males in comparison with CBA/Lac. The prolonged exposition of a female itself did not influence the testosterone output in males of both strains. However, it increased significantly the testicular response to hCG in PT strain. The data obtained suggest that a long-term exposition of a female could reinforce the testicular reactivity to hCG in genotype-dependent manner.
E A
EA
Dubovenko
L V
LV
Osadchuk
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D012102:Reproductive Control Agents / Q000494:pharmacology*; D013045:Species Specificity; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D012102:Reproductive Control Agents; D013739:Testosterone