Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression.
The aim was to ascertain any possible linkage between humoral immune responses to principal biomarkers (α-synuclein monomers, its toxic oligomers or fibrils, dopamine and S100B) and cellular immunity in Parkinson's disease development. There were elevated autoantibody titers to α-synuclein monomers, oligomers plus fibrils in 72%, 56%, and 17% of Parkinsonian patients respectively with a 5-year disease duration. Additionally, there were increased titers to dopamine and S100B (96% and 89%) in the 5-year patient group. All of these values subsided in 10-year sufferers. Furthermore, CD3+, CD4+, CD8+ T-lymphocyte and B-lymphocyte subsets declined in the patient cohort during Parkinsonism indicating disease associated reductions in these lymphocyte subsets.
P. K. Anokhin Institute of Normal Physiology RAMS, Mohovaya St. 11, Building 4, 125009 Moscow, Russia.
Marina A
MA
Gruden
Robert D E
RD
Sewell
Kiran
K
Yanamandra
Tatyana V
TV
Davidova
Valery G
VG
Kucheryanu
Evgeny V
EV
Bocharov
Olga A
OA
Bocharova
Olga R
OR
Bocharova
Vsevolod V
VV
Polyschuk
Vladimir V
VV
Sherstnev
Ludmilla A
LA
Morozova-Roche
D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D015331:Cohort Studies; D018450:Disease Progression; D004298:Dopamine / Q000276:immunology / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000276:immunology / Q000633:toxicity; D010300:Parkinson Disease / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000276:immunology / Q000633:toxicity; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051844:alpha-Synuclein / Q000276:immunology / Q000633:toxicity
D001323:Autoantibodies; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D051844:alpha-Synuclein; D004298:Dopamine