Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population.
Human longevity has been associated with mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the C150T polymorphism in the non-coding region in previous studies especially in Europeans. This study investigated the potential association between the mtDNA C150T polymorphism and longevity in a Han Chinese population. Leukocyte mtDNAs from two groups of a Han Chinese population living in Dujiangyan city of Sichuan province, including 556 longevous individuals (90-108 years-old) and 403 unrelated controls, were analyzed and mtDNA haplogroups were determined by sequencing control regions and restriction fragment length polymorphisms (RFLPs) in coding regions. Our results did not show a universal association between the mitochondrial C150T polymorphism and longevity in this population. Even when mtDNA haplogroups defined by C150T and gender were taken into account, there was no significant association with longevity. In conclusion, the mtDNA C150T polymorphism could not present an accumulation in an elderly Han Chinese population. Previous association studies might have been influenced by nuclear DNA and/or environment factors.
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Hui
H
Pan
Qing-peng
QP
Kong
Yao-ting
YT
Cheng
Shi-gang
SG
Lian
Juan
J
Yang
Shou-jun
SJ
Gao
Liang-you
LY
Xu
Ya-ping
YP
Zhang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D004272:DNA, Mitochondrial