[Basal cell carcinoma and stem cell markers : Contribution to possible histogenesis?].
The prevalence and incidence of basal cell carcinoma are on the rise. Yet, its histogenesis is still controversial. Hitherto discussed concepts are largely based on morphological analogies. Historically, basal cell carcinoma was named after its similarity to the epidermal basal cell layer which is viewed as its histogenetic origin. On the other hand, a primitive follicular origin is postulated due to the morphological similarity of basal cell carcinoma to the embryonic hair germ. In 1990, the hair follicle bulge was characterized as the anatomical niche for follicular stem cells. Early studies employing stem cell markers suggested a follicular origin of basal cell carcinoma. Since then an explosion of stem cell markers has occured in dermatology. In this review, the stem cell markers employed in the examination of basal cell carcinoma up to now are critically evaluated. Initially, studies on the histogenesis of this common dermatological tumor are reviewed.
Department of Dermatology, Cleveland Clinic Foundation, OH 44195, USA. klaus.sellheyer@gmail.com
K
K
Sellheyer
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology*; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
Br J Dermatol. 2010 Jun;162(6):1294-301
20105172
J Cutan Pathol. 2007 Feb;34(2):174-80
17244030
J Invest Dermatol. 2009 Feb;129(2):480-90
18719609
J Am Acad Dermatol. 2008 Jan;58(1):158-67
18158927
J Cell Sci. 1998 Nov;111 ( Pt 21):3179-88
9763512
J Pathol. 2002 Dec;198(4):417-27
12434410
Exp Dermatol. 2008 Jul;17(7):592-609
18558994
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3156-61
11248048
Exp Cell Res. 2008 Feb 1;314(3):498-508
18155697
Br J Dermatol. 2007 Dec;157 Suppl 2:47-51
18067632
J Am Acad Dermatol. 2010 Jul;63(1):93-113
19864043
Cell. 2004 Aug 20;118(4):409-18
15315754
J Clin Invest. 2006 Jan;116(1):249-60
16395407
Nat Cell Biol. 2010 Mar;12(3):299-305
20154679
Cells Tissues Organs. 2008;188(1-2):170-7
18160825
Nat Biotechnol. 2004 Apr;22(4):411-7
15024388
Arch Dermatol Res. 1999 May;291(5):253-9
10367707
J Invest Dermatol. 2003 Apr;120(4):501-11
12648211
Cell. 1990 Jun 29;61(7):1329-37
2364430
Arch Derm Syphilol. 1948 Apr;57(4):679-724
18886278
Differentiation. 2004 Oct;72(8):387-95
15606498
Dev Biol. 1999 Jan 1;205(1):1-9
9882493
J Am Acad Dermatol. 1989 Sep;21(3 Pt 1):523-8
2778115
Am J Dermatopathol. 1996 Apr;18(2):103-9
8739983
J Biol Chem. 2008 May 2;283(18):12426-37
18319260
J Cutan Pathol. 1999 Mar;26(3):113-8
10235375
Cell. 1995 Jan 13;80(1):83-93
7813021
Cancer Res. 2007 May 1;67(9):4173-81
17483328
J Cell Sci. 1996 May;109 ( Pt 5):1017-28
8743949
Nat Genet. 2008 Sep;40(9):1130-5
19165927
J Invest Dermatol. 2009 Nov;129(11):2711-20
19554024
Cancer Metastasis Rev. 2005 Sep;24(3):403-11
16258728
J Invest Dermatol. 2010 Apr;130(4):1048-62
19907431
J Cutan Pathol. 1978 Apr;5(2):53-67
567231
J Cutan Pathol. 1994 Jun;21(3):224-8
7525669
Exp Dermatol. 2006 Oct;15(10):794-800
16984261
J Cutan Pathol. 2011 Jul;38(7):551-9
21366662