Peptides from Royal Jelly: studies on the antimicrobial activity of jelleins, jelleins analogs and synergy with temporins.
Peptides isolated from natural fonts are the object of several studies aimed at finding new molecules possessing antibacterial activity. We focused our studies on peptides originally isolated from the Royal Jelly, the jelleins and on some analogs having a UV reporter at the N- or C-terminus. We found that jelleins are mainly active against gram-positive bacteria; interestingly, they act in synergy with peptides belonging to the family of temporins such as temporin A and temporin B against Staphylococcus aureus A170 and Listeria monocytogenes.
Department of Biological Sciences, School of Biotechnological Sciences, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy. alessandra.romanelli@unina.it
Alessandra
A
Romanelli
Loredana
L
Moggio
Rosa Chiara
RC
Montella
Pietro
P
Campiglia
Marco
M
Iannaccone
Federico
F
Capuano
Carlo
C
Pedone
Rosanna
R
Capparelli
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D002942:Circular Dichroism; D005227:Fatty Acids / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects; D008089:Listeria monocytogenes / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D000099219:Royal Jelly
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D005227:Fatty Acids; D010455:Peptides; D011506:Proteins; D000099219:Royal Jelly; C104501:temporin