Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems.
The time required for the design of a new delivery device can be sensibly reduced if the release mechanism is understood and an appropriate mathematical model is used to characterize the system. Once all the model parameters are obtained, in silico experiments can be performed, to provide estimates of the release from devices with different geometries and compositions. In this review coated and matrix systems are considered. For coated formulations, models describing the diffusional drug release, the osmotic pumping drug release, and the lag phase of pellets undergoing cracking in the coating due to the build-up of a hydrostatic pressure are reviewed. For matrix systems, models describing pure polymer dissolution, diffusion in the polymer and drug release from swelling and eroding polymer matrix formulations are reviewed. Importantly, the experiments used to characterize the processes occurring during the release and to validate the models are presented and discussed.
Department of Chemical Engineering, LTH, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
Erik
E
Kaunisto
Mariagrazia
M
Marucci
Per
P
Borgquist
Anders
A
Axelsson
D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D016503:Drug Delivery Systems; D006874:Hydrostatic Pressure; D008433:Mathematics; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry*; D012995:Solubility
D011108:Polymers