Evaluation of the neurological status in experimental acute alcohol intoxication.
Approaches to evaluation of the severity of neurological disorders in animals with experimental acute severe alcohol intoxication were developed. Using the method of statistical analysis, we selected criteria, which can be used for evaluation of the severity of inhibition of the nervous system in studies of the alcoholism pathogenesis and for improvement of methods for correction of severe intoxication at the preclinical stage of drug efficiency evaluation.
Institute of Toxicology, Federal Biomedical Agency of Russia, St. Petersburg, Russia.
E Y
EY
Bonitenko
A N
AN
Grebenyuk
V A
VA
Basharin
M B
MB
Ivanov
N V
NV
Makarova
D000435:Alcoholic Intoxication / Q000473:pathology*; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects*; D003128:Coma / Q000139:chemically induced / Q000473:pathology*; D003864:Depression, Chemical; D004562:Electrocardiography; D000431:Ethanol / Q000506:poisoning / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011930:Reaction Time / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol