Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome.
The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients with diabetes mellitus and in patients with renal failure. Through the formation of collagen crosslinks, and by interaction with the AGE-receptor, which impairs calcium handling and increases fibrosis, AGE-accumulation has pathophysiologically been associated with the development of diastolic and renal dysfunction. Interestingly, diastolic dysfunction is a frequent finding in elderly patients, diabetic patients and in patients with renal failure. Taken together, this suggests that AGEs are related to the development and progression of diastolic HF and renal failure. In this review, the role of AGEs as a possible pathophysiological factor that link the development and progression of heart and renal failure, is discussed. Finally, the role of AGE intervention as a possible treatment in HF patients will be discussed.
Department of Cardiology, University Medical Center Groningen, University of Groningen, 30.001, 9700, RB, Groningen, The Netherlands.
Suzan
S
Willemsen
Jasper W L
JW
Hartog
M Rebecca
MR
Heiner-Fokkema
Dirk J
DJ
van Veldhuisen
Adriaan A
AA
Voors
D059347:Cardio-Renal Syndrome / Q000378:metabolism* / Q000503:physiopathology; D002908:Chronic Disease; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006321:Heart / Q000503:physiopathology; D054144:Heart Failure, Diastolic / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D051437:Renal Insufficiency / Q000378:metabolism
D017127:Glycation End Products, Advanced
Diabetologia. 2004 Jul;47(7):1324-1330
15243705
Circ Res. 2004 Jun 25;94(12):1533-42
15217918
Heart. 2008 Nov;94(11):1450-5
18208832
Eur J Heart Fail. 2006 Jan;8(1):2-6
16085456
Arch Biochem Biophys. 2003 Nov 1;419(1):50-4
14568008
Diabetologia. 1996 Feb;39(2):149-60
8635666
Diabetes Care. 2009 Jul;32(7):1218-20
19366975
J Am Coll Cardiol. 2009 Feb 17;53(7):582-588
19215832
Eur J Heart Fail. 2010 Oct;12(10):1092-100
20685687
Nephrol Dial Transplant. 2006 Jun;21(6):1611-7
16520354
Diab Vasc Dis Res. 2009 Jan;6(1):7-14
19156622
Amino Acids. 2012 Apr;42(4):1151-61
20957395
Eur J Heart Fail. 2011 Jan;13(1):76-82
20861128
Biochim Biophys Acta. 2004 Mar 22;1636(2-3):82-9
15164755
J Clin Invest. 1997 Feb 1;99(3):457-68
9022079
Nephrol Dial Transplant. 2000;15 Suppl 2:7-11
11051031
Semin Dial. 2002 Sep-Oct;15(5):329-37
12358637
Am J Cardiol. 1996 May 1;77(11):1017-20
8644628
J Am Soc Nephrol. 2006 Jul;17(7):2034-47
16738019
Circulation. 2002 Mar 19;105(11):1387-93
11901053
Clin Chem. 2004 Jul;50(7):1222-8
15131022
Am J Kidney Dis. 2006 Feb;47(2):294-300
16431258
Am Heart J. 2007 Apr;153(4):656-64
17383308
Circulation. 2006 Feb 7;113(5):671-8
16461840
Metabolism. 2006 Dec;55(12):1619-24
17142134
Contrib Nephrol. 2010;165:54-67
20427956
J Card Fail. 2008 Sep;14(7):596-602
18722326
Eur J Heart Fail. 2010 Mar;12(3):294-300
20100811
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11704-8
7972128
N Engl J Med. 2004 May 6;350(19):1953-9
15128895
Am J Cardiol. 2008 Jul 1;102(1):79-83
18572040
J Card Fail. 2000 Sep;6(3):187-93
10997743
Eur J Heart Fail. 2010 Apr;12(4):397-403
20154337
Can J Cardiol. 2002 Dec;18(12):1331-9
12518185
Kidney Int Suppl. 2001 Feb;78:S25-31
11168978
Am J Kidney Dis. 2004 Jun;43(6):966-75
15168376
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13915-20
9391127
Circulation. 2006 Jun 27;113(25):2914-8
16785337
J Mol Cell Cardiol. 2002 Oct;34(10):1425-31
12393002
Cardiology. 2008;110(3):191-8
18057890
J Am Coll Cardiol. 2007 Aug 21;50(8):768-77
17707182
Eur J Heart Fail. 2007 Sep;9(9):872-8
17586090
Eur J Heart Fail. 2007 Dec;9(12):1146-55
18023248
N Engl J Med. 2003 May 15;348(20):2007-18
12748317
J Am Coll Cardiol. 2008 Sep 2;52(10):818-27
18755344
Am J Med Sci. 2003 Apr;325(4):168-78
12695722
Blood Purif. 2003;21(1):29-36
12566658
Annu Rev Med. 1995;46:223-34
7598459
Eur Heart J. 2007 Dec;28(23):2879-85
17986469
Ann N Y Acad Sci. 2008 Apr;1126:225-30
18448821
Curr Opin Nephrol Hypertens. 2010 Nov;19(6):527-33
20844429
J Am Coll Cardiol. 2001 Oct;38(4):955-62
11583864
J Am Soc Nephrol. 2003 Mar;14(3):728-31
12595509
Kidney Int. 2002 Jul;62(1):301-10
12081592
J Card Fail. 2007 Apr;13(3):199-206
17448417
J Card Fail. 2007 Oct;13(8):599-608
17923350
Circulation. 2002 Mar 26;105(12):1503-8
11914262
J Card Fail. 2008 Mar;14(2):133-9
18325460
Eur J Heart Fail. 2006 Jun;8(4):404-8
16309953
Drugs. 2004;64(5):459-70
14977384
Diabetes Care. 2004 Aug;27(8):1879-84
15277411
Nephrol Dial Transplant. 2003 May;18(5):892-8
12686661
J Am Soc Nephrol. 2005 Dec;16(12):3687-93
16280473
N Engl J Med. 2006 Jul 20;355(3):260-9
16855266
Ann N Y Acad Sci. 2005 Jun;1043:299-307
16037252
Transplantation. 2009 Apr 15;87(7):1069-77
19352130
Clin Nephrol. 1994 Dec;42(6):354-61
7882598
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 1;877(7):610-4
19188098
Eur J Heart Fail. 2008 Oct;10(10):933-89
18826876
Circulation. 2002 Feb 19;105(7):816-22
11854121
Drugs. 1990;39 Suppl 4:10-21; discussion 22-4
2354670
Cardiovasc Ultrasound. 2007 Sep 26;5:32
17897465
Diabetes Res Clin Pract. 2006 Nov;74(2):201-3
16737758
Arterioscler Thromb Vasc Biol. 2005 May;25(5):1032-7
15731496
J Nephrol. 2006 Mar-Apr;19(2):155-60
16736413
J Am Coll Cardiol. 2000 Mar 1;35(3):681-9
10716471
Kidney Int. 1998 Feb;53(2):416-22
9461101
N Engl J Med. 2000 Oct 19;343(16):1179-82
11036126
Eur Heart J. 1998 May;19(5):696-710
9717002
N Engl J Med. 2006 Jul 20;355(3):251-9
16855265
Circ Cardiovasc Imaging. 2009 Nov;2(6):437-43
19920041