[Construction and characterization of a selective membrane electrode for tenoxicam determination].
This paper describes the construction and characterization of a selective membrane electrode which can be used for determination of tenoxicam.


METHODS
The electroactive compound is a precipitate obtained in 2 N hydrocloric acid solution containing tenoxicam in which a solution of iodine is added. The membrane is made by mixing the electroactive compound with polyethylene using tetrahydrofurane as solvent. The solution is evaporated in order to obtain a thick membrane, which is attached at one end of a PVC tube and is fixed with the same polymeric solution. In this tube an internal Ag/AgCl reference electrode is inserted. The assembly is filled with an internal solution containing tenoxicam. The electrode was characterized (electrode slope, selectivity, optimal pH range, response time, life time). The developed method was validated.


RESULTS
The method showed a good liniarity in the range of 10(-6)-10(-1) M (the correlation coefficient r = 0.9999). The detection limit (LD) was 7.347 x 10(-7) M and the quantification limit (LQ) was 1.017 x 10(-6) M. There were established the precision (RSD = 1.79%) and the accuracy (mean recovery is 100.17%)


CONCLUSIONS
The experimental results demonstrated a good sensibility.
Disciplina de Chimie Analitich, Facultatea de Farmacie, Universitatea de Medicină Si Farmacie Gr.T. Popa Iaşi
Andreea Elena
AE
Murăraşu
Mariana
M
Mândrescu
A F
AF
Spac
V
V
Dorneanu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000737:chemistry; D004566:Electrodes; D005663:Furans; D006851:Hydrochloric Acid / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D008564:Membrane Potentials; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D020959:Polyethylene; D011108:Polymers / Q000737:chemistry; D011199:Potentiometry / Q000379:methods
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005663:Furans; D011108:Polymers; D010894:Piroxicam; C018674:tetrahydrofuran; D020959:Polyethylene; D007455:Iodine; D006851:Hydrochloric Acid; C032801:tenoxicam