Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and its prevalence is likely to reach epidemic proportions. According to the "two-stage hypothesis" proposed for the pathophysiology of NAFLD, insulin resistance, oxidative stress and pro-inflammatory cytokines are among the key promoters of the disease. Here, ginger has been hypothesized to prevent NAFLD or blunt its progression via several mechanisms, such as sensitizing insulin effects, activating peroxisome proliferator-activated receptor γ which induces adiponectin and down-regulates pro-inflammatory cytokines, changing the balance between adiponectin and tumor necrosis factor-α in favor of adiponectin, promoting considerable antioxidant effects and antidyslipidemic properties, and reducing hepatic triglyceride content which can prevent steatosis. The aforementioned mechanisms imply that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD. Therefore, conducting trials to explore its benefits in clinical practice is greatly recommended.
Amirhossein
A
Sahebkar
D052242:Adiponectin / Q000378:metabolism; D000975:Antioxidants / Q000737:chemistry; D005234:Fatty Liver / Q000473:pathology / Q000628:therapy; D020939:Zingiber officinale / Q000737:chemistry*; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D018384:Oxidative Stress; D047495:PPAR gamma / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use*; D015995:Prevalence; D014280:Triglycerides / Q000378:metabolism
D052242:Adiponectin; D000975:Antioxidants; D047495:PPAR gamma; D010936:Plant Extracts; D014280:Triglycerides
Biochem Biophys Res Commun. 2009 Apr 24;382(1):134-9
19268427
Eur Rev Med Pharmacol Sci. 2005 Sep-Oct;9(5):299-304
16231594
Hippokratia. 2009 Apr;13(2):127; author reply 128
19561788
World J Gastroenterol. 2008 Jan 7;14(1):22-8
18176957
Biochem Biophys Res Commun. 2008 Aug 29;373(3):429-34
18577375
Fitoterapia. 2008 Apr;79(3):174-8
18182172
Clinics (Sao Paulo). 2008 Dec;63(6):807-13
19061005
Food Chem Toxicol. 2007 Nov;45(11):2267-72
17637489
Basic Clin Pharmacol Toxicol. 2010 May;106(5):389-95
20002065
Biofactors. 2004;22(1-4):153-6
15630272