TP53 codon 72 polymorphism is associated with coronary artery disease in Chilean subjects.
OBJECTIVE
To investigate the possible association between the codon 72 polymorphism (Pro72Arg, rs1042522) of the tumor suppressor gene (TP53) and the presence of coronary artery disease (CAD) in Chilean subjects.


METHODS
A total of 209 unrelated patients with a diagnosis of CAD confirmed by angiography (33-74 years old) and 216 healthy controls (30-68 years old) were included in this study. The Pro72Arg polymorphism of the TP53 gene was evaluated by PCR-RFLP.


RESULTS
The genotype distribution for the Pro72Arg variant of the TP53 gene in CAD patients (PP: n = 13, 6.2%; PR: n = 61, 29.4%; RR: n = 135, 64.6%) and controls (PP: n = 18, 8.3%; PR: n = 94, 43.5%; RR: n = 104, 48.1%) was significantly different (p = 0.003). Similarly, the allelic frequency was also different (p = 0.003). The odds ratio for CAD related to the 72Arg allele was 2.0 (95% CI = 1.33-2.90), confirming the presence of an association.


CONCLUSIONS
These findings suggest that the Pro72Arg polymorphism of the TP53 gene is associated with CAD in Chilean individuals.
Departamento de Ciencias Básicas, Universidad de La Frontera, Temuco, Chile.
José
J
Caamaño
Nicolás
N
Saavedra
Priscilla C
PC
Jaramillo
Cecilia
C
Lanas
Fernando
F
Lanas
Luis A
LA
Salazar
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D002677:Chile / Q000453:epidemiology; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D005838:Genotype; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk; D011795:Surveys and Questionnaires; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53