Immunoglobulin light (IgL) chains in ectothermic vertebrates.
Four major ancesteral IgL isotypes have been identified κ, λ, σ and σ-cart. However, depending on the vertebrate class the genomic representation of these isotypes differs in regards to what is encoded in the germline and how these genes are organized. Also, the relative contribution of each isotype in immune responses varies. This review focuses on the IgL chains of ectothermic vertebrates, specifically the number of different isotypes, their phylogenetic relationship, genomic organizations and expression.
Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216, United States.
Eva-Stina
ES
Edholm
Melanie
M
Wilson
Eva
E
Bengten
D000818:Animals; D005075:Biological Evolution; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000235:genetics*; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D010802:Phylogeny; D014714:Vertebrates / Q000235:genetics / Q000276:immunology
D007132:Immunoglobulin Isotypes; D007147:Immunoglobulin Light Chains