Possible mechanisms for the effect of protein sensitization on functional properties of the isolated m. soleus and m. EDL from mice.
We studied possible involvement of ATP in the influence of protein sensitization on contractile function and non-quantum secretion in the end-plate of isolated skeletal muscles from mouse leg. The dynamic vector of muscle contraction force was shown to correlate with changes in non-quantum secretion of acetylcholine under various conditions of experimental pathology. However, the degree of these changes was lower in sensitized animals. It can be hypothesized that the ATP-induced variability in functional properties of slow muscles during protein sensitization reflects the development of resistance to external loads. The adaptive changes in fast muscles during protein sensitization are not associated with the ATP-mediated mechanisms of excitation.
Department of Pathophysiology, Kazan State Medical University, Kazan, Russia. AlikTeplov@.mail.ru
A Yu
AY
Teplov
A M
AM
Farkhutdinov
O V
OV
Teplov
S N
SN
Grishin
M M
MM
Minnebaev
D000109:Acetylcholine / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001696:Biomechanical Phenomena; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*
D000255:Adenosine Triphosphate; D000109:Acetylcholine