EGFR expression correlates with decreased disease-free survival in triple-negative breast cancer: a retrospective analysis based on a tissue microarray.
The aim of this study was to analyze the prognostic value of EGFR expression for patients with triple-negative breast cancer (TNBC). Clinical data of these patients were collected and analyzed, and immunohistochemical staining for EGFR was performed on tissue microarrays of operable breast cancer from 287 patients with TNBC, who were treated at Sun Yat-sen University Cancer Center from January 1995 to December 2008. EGFR expression was found in 36.2% of the cases with TNBC. A significant correlation was found between EGFR expression and disease-free survival (DFS). Univariated analysis indicated that EGFR expression had a significant prognostic value in TNBC patients, whereas multivariate analysis indicated that EGFR was a significant independent prognostic factor of DFS (P = 0.011) in all patients. Our results suggested that EGFR was an independent prognostic factor of DFS in patients with TNBC. Therefore, EGFR could become a good therapeutic target in the treatment of TNBC.
State Key Laboratory of Oncology in South China, Guangzhou 510060, People's Republic of China.
Donggen
D
Liu
Jiehua
J
He
Zhongyu
Z
Yuan
Shusen
S
Wang
Roujun
R
Peng
Yanxia
Y
Shi
Xiaoyu
X
Teng
Tao
T
Qin
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C512478:EGFR protein, human
Breast Cancer Res Treat. 2002 Jan;71(1):67-75
11859875
Histopathology. 2008 Jan;52(1):108-18
18171422
Cancer. 2007 May 1;109(9):1721-8
17387718
Clin Cancer Res. 2004 Aug 15;10(16):5367-74
15328174
Breast Cancer Res. 2008;10(1):R20
18307763
Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4429-34
17671126
Pathology. 2009 Jan;41(1):89-99
19089744
Breast Cancer Res Treat. 2008 Sep;111(1):27-44
17922188
Cancer. 2008 Nov 15;113(10):2638-45
18833576
Clin Chim Acta. 1997 Jun 27;262(1-2):99-119
9204213
Cancer. 2005 Aug 15;104(4):676-81
15981280
Nat Med. 1998 Jul;4(7):844-7
9662379
Clin Cancer Res. 2007 Apr 15;13(8):2329-34
17438091
J Clin Pathol. 2009 Feb;62(2):139-46
18682421
N Engl J Med. 2008 Mar 13;358(11):1160-74
18337605
Ann Oncol. 2008 Sep;19(9):1561-5
18534964
Clin Cancer Res. 2008 Dec 15;14(24):8010-8
19088017
Endocr Rev. 1992 Feb;13(1):3-17
1313356
BMC Cancer. 2007 Jul 24;7:134
17650314
Clin Cancer Res. 2008 Mar 1;14(5):1368-76
18316557