Molecular epidemiology of chikungunya virus in Malaysia since its first emergence in 1998.
Malaysia experienced the first outbreak of chikungunya (CHIK) in Klang in late 1998 due to CHIK virus of Asian genotype. The CHIK virus of Asian genotype reemerged causing outbreak in Bangan Panchor, Perak in March 2006. CHIK virus of Central/East African genotype was first detected from a patient who returned from India in August 2006. In December 2006, CHIK virus of Central/East African genotype was re-introduced into Malaysia from India and caused an outbreak in Kinta district, Perak but was successfully controlled following an early detection and institution of intensive vector control measures. In late April 2008, CHIK virus of Central/East African genotype was laboratory confirmed as the cause of CHIK outbreak in Johore which spread to other parts of Malaysia by August 2008. Phylogenetic analysis based on the 254-bp fragment of the virus envelope protein gene as the genetic marker showed that three different strains of CHIK virus of Central/East African genotype were introduced into Malaysia on three separate occasions from 2006 to 2008. The strain that was introduced into Johor state was responsible for its subsequent spread to other parts of Malaysia, inclusive of Sarawak.
National Public Health Laboratory, Ministry of Health, Lot 1853, 47000 Sungai Buloh, Selangor, Malaysia.
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Chem
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Zainah
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Berendam
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Rogayah
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Khairul
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Chua
D018354:Alphavirus Infections / Q000453:epidemiology; D001483:Base Sequence; D065632:Chikungunya Fever; D002646:Chikungunya virus / Q000235:genetics*; D004196:Disease Outbreaks; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D013997:Time Factors