Zinc: a promising agent in dietary chemoprevention of cancer.
Proper intake of dietary nutrients is considered crucial for preventing the initiation of events leading to the development of carcinoma. Many dietary compounds have been considered to contribute in cancer prevention including zinc, which plays a pivotal role in host defense against the initiation and promotion of several malignancies. Zinc is an essential element that is integral to many proteins and transcription factors which regulate key cellular functions such as the response to oxidative stress, DNA replication, DNA damage repair, cell cycle progression, and apoptosis. Zinc has been ascribed roles in the metabolism and interaction of malignant cells, particularly in apoptosis. Zinc is involved in structural stabilization and activation of the p53 that appears to be an important component of the apoptotic process and also in activation of certain members of the caspase family of proteases. Zinc exerts a positive beneficial effect against chemically induced preneoplastic progression in rats and provides an effective dietary chemopreventive approach to disease in vulnerable section of population with family history of carcinoma. The present review provides an insight into the research conducted on animals as well as on human subjects for providing the concept that zinc deficiency is an important factor in the development and progression of malignancy and that zinc could be efficacious in the prevention and treatment of several cancers viz., colon, pancreas, oesophageal and head and neck. However, it needs further exploration with regard to other definitive bioassays including protein expression and documentation of specific molecular markers to establish the exact mechanism for zinc-mediated cancer chemoprevention. Preclinical trials need to investigate the genetic and epigenetic pathways of chemoprevention by zinc.
Department of Biophysics, Panjab University, Chandigarh, India. dhawan@pu.ac.in
D K
DK
Dhawan
Vijayta D
VD
Chadha
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002277:Carcinoma / Q000188:drug therapy* / Q000517:prevention & control*; D053178:Caspase 6 / Q000378:metabolism; D006801:Humans; D051381:Rats; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D015032:Zinc / Q000172:deficiency / Q000378:metabolism* / Q000627:therapeutic use*
D016159:Tumor Suppressor Protein p53; D053178:Caspase 6; D015032:Zinc
J Natl Cancer Inst. 1978 Jul;61(1):145-50
276623
Biochemistry. 1990 Jun 19;29(24):5647-59
2200508
J Nutr. 2008 Apr;138(4):667-73
18356318
Oncol Res. 2009;18(1):17-23
19911700
J Nutr. 2003 Aug;133(8):2543-8
12888634
Toxicology. 2000 Nov 30;155(1-3):17-26
11154793
Drug Chem Toxicol. 2006 Jan;29(1):11-24
16455587
Toxicol Lett. 2007 Jun 15;171(1-2):10-8
17590543
Toxicol Mech Methods. 2006;16(1):37-40
20021039
J Cell Biochem. 2004 Oct 1;93(2):345-57
15368361
J Natl Cancer Inst. 2005 Feb 16;97(4):301-6
15713965
Science. 1993 Nov 19;262(5137):1274-7
8235659
J Nutr Biochem. 2004 Oct;15(10):572-8
15542347
Mol Carcinog. 1998 Mar;21(3):205-14
9537652
Lancet. 1991 Apr 13;337(8746):925-6
1673011
Br J Cancer. 1973 Dec;28(6):530-43
4131500
Eur Urol. 2007 Oct;52(4):1052-6
17292532
J Am Coll Nutr. 1998 Oct;17(5):409-18
9791836
Hell J Nucl Med. 2006 Jan-Apr;9(1):22-6
16617389
J Natl Cancer Inst. 2001 Oct 17;93(20):1525-33
11604475
Lab Invest. 1993 Jul;69(1):101-10
8331893
Mech Ageing Dev. 2002 Mar 31;123(6):675-94
11850030
Cancer Res. 1993 Oct 15;53(20):4767-8
8402657
Toxicol Lett. 2006 Jun 1;163(3):235-41
16378699
Carcinogenesis. 1998 Sep;19(9):1591-6
9771929
Biochem J. 1999 Jan 15;337 ( Pt 2):311-7
9882630
Cancer Causes Control. 2005 Oct;16(8):901-15
16132800
Toxicol Lett. 2006 Mar 15;162(1):29-42
16310985
Oncogene. 1999 Jun 17;18(24):3617-25
10380883
Immunopharmacol Immunotoxicol. 1992;14(4):813-40
1338205
Prostate Cancer Prostatic Dis. 2004;7(2):111-7
15175662
Pathol Biol (Paris). 2002 Apr;50(3):212-21
11980336
Science. 1994 Jul 15;265(5170):346-55
8023157
Biol Trace Elem Res. 2001 Summer;82(1-3):1-8
11697759
Biomed Pharmacother. 2003 Nov;57(9):399-411
14652165
Carcinogenesis. 1995 Feb;16(2):259-65
7859357
J Neuroimmunol. 1998 Jun 15;86(2):111-22
9663556
Liver Int. 2008 Apr;28(4):558-65
18339081
Mol Cell Biochem. 2007 Oct;304(1-2):101-8
17530192
Mutat Res. 2001 Apr 18;475(1-2):161-7
11295161
J Nutr. 1995 May;125(5):1167-74
7738676
J Natl Cancer Inst. 2004 Mar 3;96(5):403-7
14996862
Physiol Rev. 1993 Jan;73(1):79-118
8419966
Prostate. 1999 Aug 1;40(3):200-7
10398282
Arch Toxicol. 2006 Jan;80(1):1-9
16187101
Front Biosci. 2005 Sep 01;10:2230-9
15970489
J Neurosci. 2000 Dec 1;20(23):RC111
11090611
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16770-5
12481036
Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):640-5
19684515
Biochem Biophys Res Commun. 1998 Nov 9;252(1):190-4
9813168
Am Fam Physician. 1988 Apr;37(4):267-70
3358349
Br J Cancer. 1999 Jan;79(2):244-50
9888464
Genes Dev. 1993 Dec;7(12B):2556-64
8276238
Chem Biol Interact. 2005 Oct 20;156(2-3):131-40
16169541
J Surg Oncol. 1979;12(2):107-13
491677
Free Radic Biol Med. 2002 Mar 1;32(5):431-45
11864783
Hum Exp Toxicol. 1998 Feb;17(2):105-10
9506261
Oncogene. 2000 Nov 2;19(46):5227-36
11077439
J Nutr. 2000 May;130(5S Suppl):1459S-66S
10801960
J Leukoc Biol. 1994 Feb;55(2):221-6
7507967
FEBS Lett. 1989 Oct 23;257(1):138-40
2572457