Role of the brain dopaminergic and opioid system in the regulation of "child's" (maternal bonding) behavior of newborn albino rats.
Administration of D(2) receptor antagonist clebopride in a dose not affecting locomotor activity was followed by a decrease in maternal bonding behavior of 10-day-old and 15-day-old albino rat pups. D(1) receptor antagonist SCH23390 had a stimulatory effect only on the behavior of 10-day-old newborns. Opioid peptide β-casomorphin-7 abolished the effect of clebopride in rat pups of the older age group.
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia.
I S
IS
Stovolosov
V A
VA
Dubynin
A A
AA
Kamensky
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004723:Endorphins / Q000494:pharmacology; D009769:Object Attachment; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats
D001549:Benzamides; D001552:Benzazepines; D018492:Dopamine Antagonists; D004723:Endorphins; D010446:Peptide Fragments; C534628:SCH 23390; C041128:beta-casomorphin 7; C014417:clebopride