CD40 is overexpressed by HPV16/18-E6 positive cervical carcinoma and correlated with clinical parameters and vascular density.
CD40 is expressed in many tumor cells, however, its role in tumor biology is yet to be demonstrated. In the present study, we investigated the role of CD40 in cervical carcinoma. In vivo, we evaluated CD40 expression in 56 cervical carcinoma tissues, 43 cervicitis and 38 normal cervix, and investigated the relationship between CD40 and HPV antigen, histopathological parameters, vascular density, and vascular endothelial growth factor (VEGF) expressions. The results clearly demonstrated that CD40 expression, including membranous and cytoplasmic staining, was significantly higher in cervical carcinoma than in the cervicitis and normal cervix. The expression of CD40 was significantly correlated with HPV and VEGF expressions and microvessel density (MVD). These observations provide evidence that CD40 may be involved in neovascularization of cervical carcinoma, they also suggest that CD40 and VEGF may be useful biomarkers for evaluating the risk of developing cervical carcinoma, and may also be used as a target for therapy.
Clinical Immunology Laboratory, The First Affiliated Hospital of Soochow University, 188# Shizi Street, Suzhou 215006, China.
Qin
Q
Huang
Qiu-Xia
QX
Qu
Fang
F
Xie
Ting
T
Zhang
Jian-Ming
JM
Hu
You-Guo
YG
Chen
Xue-Guang
XG
Zhang
D000328:Adult; D000368:Aged; D019013:CD40 Antigens / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005260:Female; D052162:Human papillomavirus 16; D052161:Human papillomavirus 18; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology / Q000821:virology; D009856:Oncogene Proteins, Viral / Q000096:biosynthesis*; D030361:Papillomavirus Infections / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D012097:Repressor Proteins / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000098:blood supply / Q000378:metabolism / Q000473:pathology / Q000821:virology
D019013:CD40 Antigens; D004268:DNA-Binding Proteins; C068651:E6 protein, Human papillomavirus type 16; C052603:E6 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins