Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.
Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo. In vitro, nobiletin suppressed osteoclast formation and bone resorption induced by interleukin (IL)-1. Nobiletin suppressed the expression of cyclooxygenase-2, NFκB-dependent transcription, and prostaglandin E (PGE) production induced by IL-1 in osteoblasts. OVX mice showed severe bone loss in the femur by increased bone resorption due to estrogen deficiency, and nobiletin significantly restored the bone mass. Nobiletin could be beneficial to bone health in postmenopausal women.
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Japan.
Suguru
S
Harada
Tsukasa
T
Tominari
Chiho
C
Matsumoto
Michiko
M
Hirata
Morichika
M
Takita
Masaki
M
Inada
Chisato
C
Miyaura
D000818:Animals; D001862:Bone Resorption / Q000139:chemically induced / Q000517:prevention & control*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D003864:Depression, Chemical; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D047309:Flavones / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007375:Interleukin-1; D051379:Mice; D016328:NF-kappa B / Q000502:physiology*; D010006:Osteoblasts / Q000378:metabolism*; D010010:Osteoclasts / Q000187:drug effects; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D010052:Ovariectomy; D011458:Prostaglandins E / Q000096:biosynthesis*; D014158:Transcription, Genetic / Q000187:drug effects
D004967:Estrogens; D047309:Flavones; D007375:Interleukin-1; D016328:NF-kappa B; D011458:Prostaglandins E; C008661:nobiletin; D051546:Cyclooxygenase 2