Openness and conscientiousness predict 34-week patterns of Interleukin-6 in older persons.
Studies have indicated that personality may be associated with inflammatory markers such as Interleukin (IL)-6. One pathway between personality and IL-6 may be health behaviors and conditions resulting in inflammation, while an alternate pathway involves activation of stress-response systems. In a clinical trial sample of 200 older adults, we examined associations between personality traits at baseline and three measures of IL-6 spanning 34 weeks of follow-up. Results indicate that IL-6 remained very stable over time, and that higher Conscientiousness and Openness were associated with lower IL-6 across the entire 34 week period. Goal striving was the active subcomponent of Conscientiousness, while aesthetic interests was the active subcomponent of Openness in IL-6 associations. Common health behaviors and chronic illness accounted for only a portion of these effects, suggesting that other behavioral and/or physiological processes may also predispose some persons to inflammation. Personality phenotype may provide useful prognostic information for inflammation. Older adults lower in Conscientiousness and Openness constitute a target population for anti-inflammatory interventions. Openness and Conscientiousness predicts 32-week patterns of Interleukin-6 in older persons.
Center for Mind-Body Research, Department of Psychiatry, University of Rochester Medical Center, USA. ben_chapman@urmc.rochester.edu
Benjamin P
BP
Chapman
Edwin
E
van Wijngaarden
Christopher L
CL
Seplaki
Nancy
N
Talbot
Paul
P
Duberstein
Jan
J
Moynihan
D000368:Aged; D001294:Attitude to Health; D001519:Behavior; D005260:Female; D015438:Health Behavior; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008137:Longitudinal Studies; D018448:Models, Immunological; D010551:Personality / Q000502:physiology*; D011603:Psychophysiology; D012016:Reference Values; D013694:Temperament / Q000502:physiology*
D015850:Interleukin-6
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