Body weight-tailored contrast material injection protocol for 64-detector row computed tomography coronary angiography.
OBJECTIVE
The aim of this study was to assess the body weight-tailored contrast material injection protocol for 64-detector computed tomography (CT) to maintain optimal coronary CT attenuation.


METHODS
A total of 60 patients who underwent CT coronary angiography were assigned to one of three groups: protocol A, total of 0.7 ml kg(-1) with 300 mg I/ml iodine concentration; protocol B, total of 0.6 ml kg(-1) with 350 mg I/ml; protocol C, total of 0.7 ml kg(-1) with 350 mg I/ml. The injection duration was 10 s in all patients. The proportion of intracoronary attenuation values >325 HU was compared on a pervessel and per-patient basis.


RESULTS
The attenuation value was significantly more likely to exceed 325 HU with protocol C (95% for reader 1 and 90% for reader 2) than with protocol A or B on the per-vessel analysis (P < 0.05). The attenuation value also significantly exceeded 325 HU with protocol C (95% and 90%, respectively) more often than with protocol A or B on the per-patient analysis (P < 0.05).


CONCLUSIONS
A total of at least 0.7 ml kg(-1) contrast material with 350 mg/ml iodine concentration is required to achieve optimal coronary CT attenuation (>325 HU) with 64-detector CT when using an injection duration of 10 s.
Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan.
Tsuyoshi
T
Isogai
Masahiro
M
Jinzaki
Yutaka
Y
Tanami
Hiroyuki
H
Kusuzaki
Minoru
M
Yamada
Sachio
S
Kuribayashi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001835:Body Weight; D003287:Contrast Media / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D007472:Iohexol
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