Development ontogenesis of receptor tracheobronchial system in isolated preparations of pigs trachea in vitro.
Flow research of the development of receptor bronchial system was conducted in this work since the first day in 4th week of extra-uterine life, by following reactions of isolated tracheal rings in acetylcholine (Ach), histamine (Hist), and prostaglandin (PGF2-alfa) in concentrations of: 10(-4), 10(-3), 10(-2), 10(-1), mol/dm3, at piggy's of ages: 1 day, 1 week, 2 weeks and 4 weeks. Results shows that Ach causes reaction of smooth muscles since the first day of extra-uterine life in a significant way (p < 0.01). Whilst propranolol (P) not emphasis the effect of Ach in a significant way (p > 0.1). Whereas histamine, and PGF2- alpha does not cause constriction of tracheal smooth musculature (MLT) in the first days of extra-uterine life. This shows that cholinergic and adrenergic system in airways of pigs is developed in intrauterine life and reaction was registered since the first day of extra-uterine life, whereas other receptor systems are developed in later weeks of extra-uterine life. Potential explanation of this mechanism of constriction of tracheal rings smooth musculature, dependence-age, is increase of the Calcium ions influx throughout "receptor-activating" and "voltage operating" channels in cells of the pigs tracheal smooth musculature in the first days of extra-uterine life.
Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova. islamihilmi@hotmail.com
Hilmi
H
Islami
Vehbi
V
Shehu
Bedri
B
Abdullahu
Valon
V
Krasniqi
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001980:Bronchi / Q000378:metabolism*; D015237:Dinoprost / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000378:metabolism; D011433:Propranolol / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D034421:Sus scrofa; D014132:Trachea / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D006632:Histamine; D011433:Propranolol; D015237:Dinoprost; D000109:Acetylcholine