Automated production of [11C]acetate and [11C]palmitate using a modified GE Tracerlab FX(C-Pro).
As researchers explore new applications for positron emission tomography radiopharmaceuticals, the demand for effective and readily available radiopharmaceuticals continues to increase. The syntheses of two such radiopharmaceuticals, [(11)C]acetate and [(11)C]palmitate, can be automated on the GE Tracerlab FX(C-Pro) by utilizing Grignard reactions. Radiochemical purities of the [(11)C]acetate and the [(11)C]palmitate products were high (>98% and >99.9%, respectively) with average non-corrected yields of 18% (n = 3) and 10% (n = 5), respectively. These data comprise the validation trials for site qualification of clinical production of both radiopharmaceuticals.
Department of Radiology, University of Michigan Medical School, Ann Arbor, 48109, USA.
Adam C
AC
Runkle
Xia
X
Shao
Louis J M
LJ
Tluczek
Bradford D
BD
Henderson
Brian G
BG
Hockley
Peter J H
PJ
Scott
D019342:Acetic Acid / Q000138:chemical synthesis*; D001331:Automation; D002250:Carbon Radioisotopes / Q000737:chemistry*; D019308:Palmitic Acid / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography
D002250:Carbon Radioisotopes; D019308:Palmitic Acid; D019342:Acetic Acid