Study of biological activity of Lys-Glu-Asp-Trp-NH2 endogenous tetrapeptide.
Biological effect of natural tetrapeptide Lys-Glu-Asp-Trp-NH(2)was evaluated during the ontogeny and in experimental streptozotocin-induced diabetes mellitus (a model of rapid experimental aging) by the sum of metabolic parameters characterizing apoptosis.
St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, Moscow, Russia.
V Kh
VKh
Khavinson
M M-G
MM
Gapparov
N E
NE
Sharanova
A V
AV
Vasilyev
G A
GA
Ryzhak
D000375:Aging / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D053148:Caspase 3 / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D050417:Insulin-Secreting Cells / Q000473:pathology*; D008099:Liver / Q000378:metabolism; D008297:Male; D009336:Necrosis; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009842:Oligopeptides; C531938:lysyl-glutamyl-aspartyl-tryptophanamide; D053148:Caspase 3