Single-Boosted Protease Inhibitor versus Double-Boosted Protease Inhibitors for the Salvage Therapy in HIV-Infected Patients.
OBJECTIVE
To compare treatment outcomes between the regimens of single-boosted protease inhibitor (PI) and double-boosted PIs for the salvage therapy in patients who failed nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimens.


METHODS
A total of 64 patients from 2 cohorts, 40 in twice daily ritonavir-boosted lopinavir (LPV/r) at 400/100 mg plus lamivudine (3TC) and 24 in once daily ritonavir-boosted atazanavir and saquinavir (ATV/SQV/r) at 300/1600/100 mg/d, were studied.


RESULTS
At 48 weeks, 30 (75%) patients in LPV/r group and 20 (83%) patients in ATV/SQV/r group achieved HIV-1 RNA at <400 copies/mL (P = .790). In all, 24 (60%) and 16 (67%) achieved HIV-1 RNA at <50 copies/mL (P = .541). Low-level viral rebound (51-400 copies/mL) was found in 6 (15%) in LPV/r group and 4 (17%) in ATV/SQV/r group (P = 1.000). Medians CD4 counts were 336 cells/mm(3) and 330 cells/mm(3) in the corresponding groups (P = 0.937).


CONCLUSIONS
No additional benefit is found with double-boosted PIs compared to single-boosted PI in terms of treatment responses in HIV-infected patients failing NNRTI-based regimen.
Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, Thailand, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, drweerawat@hotmail.com.
Weerawat
W
Manosuthi
Sukanya
S
Chimsuntorn
Supeda
S
Thongyen
Samruay
S
Nilkamhang
Somnuek
S
Sungkanuparph
D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000008:administration & dosage; D006801:Humans; D019438:Ritonavir / Q000008:administration & dosage; D016879:Salvage Therapy; D019258:Saquinavir
D017320:HIV Protease Inhibitors; D019258:Saquinavir; D019438:Ritonavir