Systematizing and cloning of genes involved in the cerebellar cortex circuit development.
The cerebellar cortical circuit of mammals develops via a series of magnificent cellular events in the postnatal stage of development to accomplish the formation of functional circuit architectures. The contribution of genetic factors is thought to be crucial to cerebellar development. Therefore, it is essential to analyze the underlying transcriptome during development to understand the genetic blueprint of the cerebellar cortical circuit. In this review, we introduce the profiling of large numbers of spatiotemporal gene expression data obtained by developmental time-series microarray analyses and in situ hybridization cellular mRNA mapping, and the creation of a neuroinformatics database called the Cerebellar Development Transcriptome Database. Using this database, we have identified thousands of genes that are classified into various functional categories and are expressed coincidently with related cellular developmental stages. We have also suggested the molecular mechanisms of cerebellar development by functional characterization of several identified genes (Cupidin, p130Cas, very-KIND, CAPS2) responsible for distinct cellular events of developing cerebellar granule cells. Taken together, the gene expression profiling during the cerebellar development demonstrates that the development of cerebellar cortical circuit is attributed to the complex but orchestrated transcriptome.
Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, 351-0198, Saitama, Japan. tfuruichi@brain.riken.jp
Teiichi
T
Furuichi
Yoko
Y
Shiraishi-Yamaguchi
Akira
A
Sato
Tetsushi
T
Sadakata
Jinhong
J
Huang
Yo
Y
Shinoda
Kanehiro
K
Hayashi
Yuriko
Y
Mishima
Mineko
M
Tomomura
Hirozumi
H
Nishibe
Fumio
F
Yoshikawa
D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics; D002531:Cerebellum / Q000254:growth & development*; D003001:Cloning, Molecular; D050719:Crk-Associated Substrate Protein / Q000235:genetics / Q000502:physiology; D030541:Databases, Genetic; D005092:Exonucleases; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000502:physiology; D000072233:Homer Scaffolding Proteins; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D009185:Myelin Proteins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009474:Neurons / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology; D013569:Synapses / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D051017:Apoptosis Regulatory Proteins; C480975:CAPS2 protein, mouse; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D050719:Crk-Associated Substrate Protein; D020662:Guanine Nucleotide Exchange Factors; D000072233:Homer Scaffolding Proteins; D008562:Membrane Glycoproteins; D009185:Myelin Proteins; D009419:Nerve Tissue Proteins; C524019:Opalin protein, mouse; D014157:Transcription Factors; C511876:very-KIND protein, mouse; C485554:Aatk protein, mouse; D011505:Protein-Tyrosine Kinases; D005092:Exonucleases; C557622:PLD4 protein, mouse
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