Stillbirth in diabetic pregnancies.
Pregnancy in women with pregestational diabetes is associated with high perinatal morbidity and mortality. Stillbirth accounts for the majority of cases with perinatal death. Intrauterine growth restriction, pre-eclampsia, foetal hypoxia and congenital malformations may be contributing factors, but more than 50% of stillbirths are unexplained. Majority of stillbirths are characterised by suboptimal glycaemic control during pregnancy. Foetal hypoxia and cardiac dysfunction secondary to poor glycaemic control are probably the most important pathogenic factors in stillbirths among pregnant diabetic women. There is thus a need for new strategies for improving glycaemic control to near-normal levels throughout pregnancy and for preventing and treating hypertensive disorders in pregnancy. Antenatal surveillance tests including ultrasound examinations of the foetal growth rate, kick counting and non-stress testing of foetal cardiac function are widely used. However, future research should establish better antenatal surveillance tests to identify the infants susceptible to stillbirth before it happens.
Center for Pregnant Women with Diabetes, Rigshospitalet, Faculty of Health Science, University of Copenhagen, Denmark. em@rh.dk
Elisabeth R
ER
Mathiesen
Lene
L
Ringholm
Peter
P
Damm
D009202:Cardiomyopathies / Q000209:etiology / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005313:Fetal Death / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D007003:Hypoglycemia / Q000517:prevention & control; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology / Q000628:therapy; D011295:Prenatal Care; D012307:Risk Factors; D050497:Stillbirth / Q000453:epidemiology*