Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference.
In rodents, exposure to acute inescapable, but not escapable, stress potentiates morphine conditioned place preference (CPP), an effect that is dependent upon hyperactivation of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN). Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP.
University of Colorado-Boulder, Department of Psychology and Neuroscience, Muenzinger Building, UCB 345, Boulder, CO 80309, USA. rozeske@colorado.edu
Robert R
RR
Rozeske
Benjamin N
BN
Greenwood
Monika
M
Fleshner
Linda R
LR
Watkins
Steven F
SF
Maier
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D006380:Helplessness, Learned; D009020:Morphine / Q000494:pharmacology*; D009474:Neurons / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000523:psychology; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D012420:Running / Q000523:psychology*; D012701:Serotonin / Q000502:physiology; D013315:Stress, Psychological / Q000523:psychology*
D000701:Analgesics, Opioid; D012701:Serotonin; D009020:Morphine
Brain Res. 1998 Nov 23;812(1-2):113-20
9813270
J Neurosci. 2003 Apr 1;23(7):2889-98
12684476
Naunyn Schmiedebergs Arch Pharmacol. 1995 Aug;352(2):141-8
7477436
Neuroscience. 2004;126(3):705-15
15183519
Addict Biol. 2009 Jan;14(1):43-64
18855803
Neurosci Biobehav Rev. 2003 Aug;27(5):457-91
14505687
Scand J Public Health. 2010 Aug;38(6):664-9
20529968
Eur Neuropsychopharmacol. 2007 May-Jun;17(6-7):377-93
17169534
Synapse. 2003 Sep 1;49(3):206-8
12774305
Ment Health Phys Act. 2010 Jun 1;3(1):27-34
20582151
Neuroreport. 2004 Dec 3;15(17):2637-41
15570168
Behav Brain Res. 2008 Nov 3;193(1):87-93
18554730
Neuropsychopharmacology. 2009 Mar;34(4):834-43
18368036
Addiction. 2006 Aug;101(8):1187-92
16869848
Brain Res. 1999 Apr 24;826(1):35-43
10216194
Pharmacol Biochem Behav. 1998 Jul;60(3):655-64
9678649
J Pharmacol Exp Ther. 2002 Nov;303(2):704-10
12388654
Nat Neurosci. 2005 Mar;8(3):365-71
15696163
Neuropsychopharmacology. 2001 Jan;24(1):11-20
11106871
Neuroscience. 2007 Jun 8;146(4):1495-503
17478046
Synapse. 1987;1(1):3-9
3505364
Behav Neurosci. 1995 Jun;109(3):404-12
7662151
Brain Res. 2005 Feb 8;1033(2):164-78
15694921
Behav Neurosci. 2009 Apr;123(2):382-96
19331461
Pharmacol Biochem Behav. 2007 Apr;86(4):607-15
17368736
Psychopharmacology (Berl). 2004 Jan;171(2):191-8
13680080
Biol Psychiatry. 2005 Mar 1;57(5):559-68
15737672
Neuropsychopharmacology. 2003 Sep;28(9):1589-96
12784102
Ann N Y Acad Sci. 2010 Feb;1187:184-207
20201854
J Pharmacol Exp Ther. 2002 Nov;303(2):549-56
12388635