Effects of simvastatin on osseointegration in a canine total hip arthroplasty model: an experimental study.
Simvastatin was recently demonstrated to stimulate bone morphogenetic protein-2 expression, leading to bone formation. The present study was designed to evaluate whether simvastatin administered by injection could promote osseointegration in a canine total hip arthroplasty model. Fifteen dogs were divided into 3 groups of 5 dogs each: group 1 (high-dosage simvastatin, 6.0 mg/[kg d]), group 2 (low-dosage simvastatin, 3.0 mg/[kg d]), and a control group (isotonic saline, 3.0 mg/[kg d]). Osseointegration was assessed by using the push-out test, scanning electron microscopy, energy-dispersive spectrometer microanalysis, and histomorphometric examination. The results showed higher mechanical strength, greater area of bone covering the femoral component, and higher bone-implant contact in group 1 than in the other 2 groups. Our findings indicate that simvastatin administered by injection could contribute significantly to osseointegration in a canine total hip arthroplasty model.
Department of Orthopedics Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Han
H
Yin
Jianmin
J
Li
Xiuchun
X
Yu
Zhihou
Z
Fu
D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006621:Hip Joint / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D006622:Hip Prosthesis; D007279:Injections, Subcutaneous; D008297:Male; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D016348:Osseointegration / Q000187:drug effects*; D019821:Simvastatin / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome
D019821:Simvastatin