Association of genetic polymorphisms of eNOS with glaucoma.
OBJECTIVE
Several studies suggest that vascular dysregulation play a role in the etiology of glaucoma. In the present study, we aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG).


METHODS
There were 102 POAG and 88 PCAG patients, diagnosed on the basis of clinical history, raised intraocular pressure (IOP), cup-to-disc ratio (CDR) and visual field defects, and 120 age- and sex-matched control subjects genotyped for 5 tagging single nucleotide polymorphisms (SNPs; rs743507, rs3793342, rs11771443, rs7830, and rs3918188) of the human eNOS gene.


RESULTS
rs3793342, rs743507, rs11771443, rs7830, and rs3918188 were not found to be associated with POAG or with PCAG. In the haplotype-based case-control analysis, the frequency of the C-T haplotype established by rs3793342 and rs11771443 was significantly higher for POAG patients than for control subjects (p<0.001, OR=5.111, 95%CI=1.766~14.788).


CONCLUSIONS
The C-T haplotype established by rs3793342 and rs11771443 may be genetic marks of POAG in the Han Chinese population.
Department of Ophthalmology, The Affiliated Xinqiao Hospital of the 3rd Military Medical College, Chongqi, P.R. China.
Qiong
Q
Liao
Dai-Hong
DH
Wang
Han-Jun
HJ
Sun
D000368:Aged; D000465:Algorithms; D015331:Cohort Studies; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D015812:Glaucoma, Angle-Closure / Q000235:genetics*; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers; D052250:Nitric Oxide Synthase Type III
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