Nootropic activity of extracts from wild and cultivated Alfredia cernua.
Antihypoxic and nootropic activities of extracts from aerial parts of wild and cultivated Alfredia cernua (L.) Cass. were studied on the models of pressure chamber hypoxia, open field test, and passive avoidance conditioning. The extracts of Alfredia cernua promoted retention of the orientation reflex and passive avoidance conditioned response and normalized orientation and exploratory activities disordered as a result of hypoxic injury. The efficiency of the extracts was superior to that of piracetam by the effect on retention of passive avoidance response throughout the greater part of the experiment. Nootropic activity of cultivated Alfredia cernua was not inferior to that of the wild plant.
Laboratory of Phytopharmacology, Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. rustamustaf@sibmail.com
R N
RN
Mustafin
I V
IV
Shilova
N I
NI
Suslov
N V
NV
Kuvacheva
V P
VP
Amelchenko
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001362:Avoidance Learning / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D000431:Ethanol; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D000860:Hypoxia / Q000503:physiopathology; D051379:Mice; D018697:Nootropic Agents / Q000032:analysis / Q000494:pharmacology*; D009949:Orientation / Q000187:drug effects; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects
D018697:Nootropic Agents; D010936:Plant Extracts; D000431:Ethanol