Neuroprotective properties of resveratrol and derivatives.
Stilbenoid compounds consist of a family of resveratrol derivatives. They have demonstrated promising activities in vitro and in vivo that indicate they may be useful in the prevention of a wide range of pathologies, such as cardiovascular diseases and cancers, as well have anti-aging effects. More recently stilbenoid compounds have shown promise in the treatment and prevention of neurodegenerative disorders, such as Huntington's, Parkinson's, and Alzheimer's diseases. This paper primarily focuses on the impact of stilbenoids in Alzheimer's disease and more specifically on the inhibition of β-amyloid peptide aggregation.
Université de Bordeaux, Villenave d'Ornon, France.
Tristan
T
Richard
Alison D
AD
Pawlus
Marie-Laure
ML
Iglésias
Eric
E
Pedrot
Pierre
P
Waffo-Teguo
Jean-Michel
JM
Mérillon
Jean-Pierre
JP
Monti
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*
D018696:Neuroprotective Agents; D013267:Stilbenes; D000077185:Resveratrol