Palladium-catalyzed tandem fluorination and cyclization of enynes.
A novel palladium-catalyzed tandem fluorination and cyclization of enynes has been developed. A favorable cis-fluoropalladation is proposed as a key step to construct a vinyl-F bond, and the final C(sp3)-Pd bond is reduced by alcohol. This transformation represents an efficient road to synthesize fluorinated lactams.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China, 200032.
Haihui
H
Peng
Guosheng
G
Liu
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000480:Alkynes; D006845:Hydrocarbons, Fluorinated; D010165:Palladium