Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.
The normal counterparts of mantle cell lymphoma (MCL) are naive, quiescent B cells that have not been processed through the germinal center (GC). For this reason, although lymphomas arising from GC or post-GC B cells often exhibit plasmacytic differentiation, MCL rarely presents with plasmacytic features. Seven cases of MCL with a monotypic plasma cell (PC) population were collected from 6 centers and were studied by immunohistochemistry, fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms analysis, capillary gel electrophoresis, and restriction fragment length polymorphism of immunoglobulin heavy chain analysis of microdissections of each of the MCL and PC populations to assess their clonal relationship. The clinical presentation was rather unusual compared with typical MCL, with 2 cases arising from the extranodal soft tissues of the head. All MCL cases were morphologically and immunohistochemically typical, bearing the t(11;14)(q13;q32). In all cases, the PC population was clonal. In 5 of the 7 cases, the MCL and PC clones showed identical restriction fragments, indicating a common clonal origin of the neoplastic population. The 2 cases with clonal diversity denoted the coexistence of 2 different tumors in a composite lymphoma/PC neoplasm. Our findings suggest that MCL can present with a PC component that is often clonally related to the lymphoma, representing a rare but unique biological variant of this tumor.
Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, USA.
Carlo
C
Visco
Sylvia
S
Hoeller
Jeffrey T
JT
Malik
Zijun Y
ZY
Xu-Monette
Michele L
ML
Wiggins
Jessica
J
Liu
Warren G
WG
Sanger
Zhongfeng
Z
Liu
Julie
J
Chang
Erik A
EA
Ranheim
Joel F
JF
Gradowski
Sergio
S
Serrano
Huan-You
HY
Wang
Qingquan
Q
Liu
Sandeep
S
Dave
Brian
B
Olsen
Randy D
RD
Gascoyne
Elias
E
Campo
Steven H
SH
Swerdlow
Wing C
WC
Chan
Alexander
A
Tzankov
Ken H
KH
Young
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008221:Lymphoid Tissue / Q000378:metabolism / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D042282:Microdissection; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology*; D012150:Polymorphism, Restriction Fragment Length; D014178:Translocation, Genetic / Q000235:genetics*
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains
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