Endometrial polyps affect uterine receptivity.
This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair implantation. These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps.
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA. beth.rackow@yale.edu
Beth W
BW
Rackow
Elisa
E
Jorgensen
Hugh S
HS
Taylor
D000328:Adult; D016022:Case-Control Studies; D003237:Connecticut; D015536:Down-Regulation; D010064:Embryo Implantation / Q000235:genetics; D005260:Female; D005298:Fertility / Q000235:genetics; D005819:Genetic Markers; D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D015907:Hysteroscopy; D007247:Infertility, Female / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D011127:Polyps / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D011247:Pregnancy; D018873:Pregnancy Rate; D012333:RNA, Messenger / Q000032:analysis; D014591:Uterine Diseases / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D014599:Uterus / Q000737:chemistry / Q000503:physiopathology*; D055815:Young Adult
D005819:Genetic Markers; C484298:HOXA11 protein, human; D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins; D012333:RNA, Messenger; C069634:HOXA10 protein, human
Obstet Gynecol. 1999 Aug;94(2):168-71
10432121
Nature. 1995 Mar 30;374(6521):460-3
7700356
Biol Reprod. 1997 May;56(5):1097-105
9160706
J Reprod Med. 2005 Jul;50(7):501-6
16130847
Fertil Steril. 2010 Apr;93(6):2027-34
18555231
Mol Hum Reprod. 1999 Sep;5(9):866-73
10460226
Methods. 2001 Dec;25(4):402-8
11846609
Reprod Biomed Online. 2006 Feb;12(2):199-204
16478585
Mol Endocrinol. 2002 Mar;16(3):571-9
11875117
Development. 1995 May;121(5):1373-85
7789268
J Assist Reprod Genet. 1999 Sep;16(8):410-5
10478319
J Clin Endocrinol Metab. 2003 Jan;88(1):238-43
12519859
Gene Ther. 2000 Aug;7(16):1378-84
10981664
Biol Reprod. 2005 Oct;73(4):833-9
15987820
Dev Dyn. 2001 Nov;222(3):538-44
11747087
J Am Assoc Gynecol Laparosc. 2003 Feb;10(1):46-8
12554993
FASEB J. 2000 Jun;14(9):1101-8
10834931
Hum Reprod. 2005 Jun;20(6):1632-5
15760959
Biol Reprod. 2010 Aug 1;83(2):205-11
20463357
Fertil Steril. 2002 Sep;78(3):577-80
12215336
J Clin Endocrinol Metab. 1999 Mar;84(3):1129-35
10084606
Hum Reprod. 1999 May;14(5):1328-31
10325287
Fertil Steril. 2003 Sep;80 Suppl 2:839-43
14505762
Clin Exp Obstet Gynecol. 2003;30(1):23-5
12731738
Mol Cell Biol. 2003 Jan;23(1):1-13
12482956
J Obstet Gynaecol Res. 2004 Apr;30(2):84-9
15009608
Fertil Steril. 2009 Apr;91(4):1215-23
18339376
Am J Obstet Gynecol. 2004 Sep;191(3):767-72
15467538
J Clin Invest. 1998 Apr 1;101(7):1379-84
9525980
J Clin Endocrinol Metab. 2005 Jan;90(1):522-8
15494461
Biol Reprod. 1997 Dec;57(6):1338-45
9408238
Hum Reprod Update. 2000 Jan-Feb;6(1):75-9
10711832