Triad of visual, auditory and corticospinal tract lesions: a new syndrome in a patient with HIV infection.
OBJECTIVE
A case of a rapidly progressive degeneration of the visual, auditory and corticospinal tract in a patient with a HIV infection is presented.


RESULTS
The HIV-infected patient suffered from severe and rapidly progressive sensorineural hearing loss, blindness, dysarthria, dysphagia and tetraparesis. MRI showed degeneration of the visual, auditory and corticospinal tract. Diffusion tensor imaging showed reduced fractional anisotropy of the corticospinal tract. HAART and other salvage therapies did not save the patient from death 5 months after the onset of the symptoms.


CONCLUSIONS
The triad of auditory, visual and corticospinal lesions has been described in rare syndromes and hereditary diseases. This is the first case of this syndrome associated with a HIV infection.
Department of Neurology, University of Muenster, Germany. kleffnil@uni-muenster.de
Ilka
I
Kleffner
Heike
H
Wersching
Wolfram
W
Schwindt
Tanja
T
Kuhlmann
Kathy
K
Keyvani
Michael
M
Deppe
Ingo
I
Husstedt
D000328:Adult; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000473:pathology; D011712:Pyramidal Tracts / Q000473:pathology*; D012678:Sensation Disorders / Q000209:etiology / Q000473:pathology*; D013577:Syndrome