Cardiovascular effects of platelet-activating factor.
Platelet-activating factor (PAF) is a unique biologically active phospholipid that is synthesized by many cells and tissues and has actions far more diverse than just platelet activation. PAF is probably a mediator of the normal inflammatory and thrombotic responses. Inappropriate or excessive production of PAF can lead to vascular injury, particularly via its proinflammatory effects, and marked hemodynamic derangements. There is evidence that PAF may play a role in clinical syndromes of shock, infarction, and reperfusion injury. Antagonists of the PAF receptor have been developed and have therapeutic potential in these common life-threatening disorders.
Nora Eccles Harrison Cardiovascular Research and Training Institute USA; Departments of Internal Medicine and Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
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Holland
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McIntyre
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Zimmerman
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Prescott