[Another genetic cause of sudden cardiac death].
Mutations in the Lamin A/C gene (LMNA) are a new part of the spectrum of genes responsible for sudden cardiac death (SCD). Relatives of SCD-cases should receive counselling, clinical assessment and perhaps molecular screening. The consequence of being an LMNA mutation carrier is discussed with regard to counselling and prophylactic measures. Device therapy may be relevant in LMNA-mutation carriers, although the proper time for implantation is uncertain. However, we recommend LMNA genetic screening in SCD cases with dilated cardiomyopathy as well as cases with unexplained SCD.
Sektor for Forskning og Udvikling, Klinisk Biokemisk og Immunologisk Afdeling, Statens Serum Institut, 85/141, 2300 København S, Denmark. dvm@ssi.dk
Daniel Vega
DV
Møller
Lars
L
Køber
Ole
O
Havndrup
Tam Thanh
TT
Pham
Henning
H
Bundgaard
Michael
M
Christiansen
D002311:Cardiomyopathy, Dilated / Q000235:genetics; D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000517:prevention & control; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D034904:Lamin Type A / Q000235:genetics; D009154:Mutation
D034904:Lamin Type A; C440308:lamin C