Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats.
This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week administrations of SJW extract (125 and 250 mg/kg) induced significant decrease in high blood glucose levels of three weeks STZ-diabetic rats and improved their dysregulated metabolic parameters. In addition, SJW extract treatment caused restoration in the mechanical hyperalgesia of diabetic animals. These findings provide a rationale for the traditional use of SJW against diabetes and display the potential of this plant as a new drug candidate/source for the treatment of diabetic pain.
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Özgür Devrim
ÖD
Can
Yusuf
Y
Öztürk
Nilgün
N
Öztürk
Gianni
G
Sagratini
Massimo
M
Ricciutelli
Sauro
S
Vittori
Filippo
F
Maggi
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D020902:Hypericum; D008297:Male; D008660:Metabolism / Q000187:drug effects; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D010936:Plant Extracts