The Abelson tyrosine kinase (c-Abl) expression on the mouse uterus and placenta during gestational period.
c-Abl is a protein tyrosine kinase which has very important roles in signal transduction, control of the cell cycle, cell motility, proliferation, and inhibition of apoptosis. We hypothesized that c-Abl may play an important role on uterine remodeling during pre-receptive, receptive and non-receptive endometrium. Our aim is to investigate the expression of c-Abl protein tyrosine kinase in uterine remodeling and placental development in mouse gestational stage. We performed c-Abl immunohistochemistry on mouse uterine tissue sections on days 1-9, 11, 13, and 15 of pregnancy. c-Abl was highly upregulated in the uterine luminal epithelium and other endometrial structures including glands and blood vessels in pre-receptive and receptive endometrium. Therefore these results demonstrate a role for c-Abl in uterine remodeling during decidualization, implantation, and placentation throughout gestation.
Department of Histology and Embryology, Akdeniz University Faculty of Medicine, Campus, 07070, Antalya, Turkey.
Aylin
A
Yaba
Umit Ali
UA
Kayisli
Joshua
J
Johnson
Ramazan
R
Demir
Necdet
N
Demir
D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000378:metabolism; D004475:Ectoderm / Q000378:metabolism; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009215:Myometrium / Q000166:cytology / Q000378:metabolism; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy; D016315:Proto-Oncogene Proteins c-abl / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism
D016315:Proto-Oncogene Proteins c-abl
Trends Cell Biol. 1999 May;9(5):179-86
10322452
Exp Cell Res. 1993 Jun;206(2):212-9
7684693
Am J Reprod Immunol. 1994 Oct;32(3):226-37
7880406
J Cell Sci. 2003 Jul 1;116(Pt 13):2613-26
12775773
Semin Immunol. 1995 Aug;7(4):255-66
8520030
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7457-62
9636171
Endocrinology. 1998 Sep;139(9):3958-66
9724051
Cell Death Differ. 2000 Jan;7(1):10-6
10713716
Biol Reprod. 2004 Jun;70(6):1806-13
14973263
Dev Biol. 1994 Aug;164(2):444-55
8045347
Nat Rev Mol Cell Biol. 2004 Jan;5(1):33-44
14708008
Mol Cell Biol. 2000 Jan;20(2):661-71
10611245
Cell Res. 2005 Jan;15(1):33-5
15686624
Cancer Res. 1970 Aug;30(8):2213-22
4318922
Curr Opin Neurobiol. 2003 Oct;13(5):535-44
14630215
Dev Biol. 2000 Jul 15;223(2):217-37
10882512
Trends Cell Biol. 2004 Jan;14(1):36-44
14729179
Mol Biol Cell. 2008 May;19(5):2278-88
18353972
Genes Dev. 1999 Sep 15;13(18):2400-11
10500097
Curr Opin Neurobiol. 2000 Feb;10(1):80-7
10679439
Oncogene. 2001 May 10;20(21):2618-25
11420673
Nat Genet. 2000 Mar;24(3):304-8
10700189
Dev Biol. 1999 Aug 1;212(1):124-36
10419690
Cell. 1991 Jun 28;65(7):1153-63
2065352
J Pathol. 1997 Nov;183(3):325-9
9422989