Skp2 and Skp2B team up against Rb and p53.
The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established. More recent work from the McCormick's group suggested that Skp2 has an ubiquitin-independent function in the regulation of the p53 pathway. Adding to this observation, we reported that Skp2B also regulates the activity of p53 by degrading a distinct substrate, prohibitin. Since prohibitin has been implicated in the regulation of the Rb pathway, collectively, these observations suggest that Skp2 and Skp2B team up against p53 and Rb.
Mount Sinai School of Medicine, Tisch Cancer Institute, Division of Hematology/Oncology, One Gustave L, Levy Place, Box 1079, New York, New York 10029, USA. doris.germain@mssm.edu.
Doris
D
Germain
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