How one bad protein spoils the barrel: structural details of β2-microglobulin amyloidogenicity.
In this issue, Eichner et al. (2011) describe at atomic resolution the structure of an amyloidogenic state of β(2)-microglobulin and how it may corrupt a soluble counterpart in the pathological scenario that ensues when good proteins go to the "dark side'" and form infectious toxic amyloid.
Department of Biochemistry & Molecular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA. gierasch@biochem.umass.edu
Lila M
LM
Gierasch
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