Synthesis of 2-keto-imidazoles utilizing N-arylamino-substituted N-heterocyclic carbenes.
A new method for the synthesis of 2-aroyl-, 2-heteroaroyl-, and 2-cinnamoyl-substituted imidazoles in very good yields has been developed. The reaction employs novel nitrogen heterocyclic carbenes (NHCs), namely, N-arylamino-substituted NHCs, formed in situ from the corresponding imidazolium salts, and subsequent reaction with aromatic, heteroaromatic, and cinnamic aldehydes without utilizing transition metals or expensive specialized catalysts.
Department of Chemistry, Laboratory of Organic Chemistry, University of Thessaloniki, Thessaloniki 54124, Macedonia, Greece.
Tryfon
T
Zarganes-Tzitzikas
Constantinos G
CG
Neochoritis
Julia
J
Stephanidou-Stephanatou
Constantinos A
CA
Tsoleridis
D006571:Heterocyclic Compounds / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D006571:Heterocyclic Compounds; D007093:Imidazoles; C030011:carbene; D008697:Methane