Differential effect of corn oil-based low trans structured fat on the plasma and hepatic lipid profile in an atherogenic mouse model: comparison to hydrogenated trans fat.
BACKGROUND
Trans fat are not desirable in many aspects on health maintenance. Low trans structured fats have been reported to be relatively more safe than trans fats.


METHODS
We examined the effects of low trans structured fat from corn oil (LC), compared with high trans fat shortening, on cholesterol and fatty acid metabolism in apo E deficient mice which is an atherogenic animal model. The animals were fed a high trans fat (10% fat: commercial shortening (CS)) or a low trans fat (LC) diet for 12 weeks.


RESULTS
LC decreased apo B and hepatic cholesterol and triglyceride concentration compared to the CS group but significantly increased plasma total cholesterol and triglyceride concentration and fecal lipids with a simultaneous increase in HDL-cholesterol level, apo A-I, and the ratio of HDL-cholesterol to total cholesterol (HTR). Reduction of hepatic lipid levels by inclusion of LC intake was observed alongside modulation of hepatic enzyme activities related to cholesterol esterification, fatty acid metabolism and fecal lipids level compared to the CS group. The differential effects of LC intake on the plasma and hepatic lipid profile seemed to be partly due to the fatty acid composition of LC which contains higher MUFA, PUFA and SFA content as well as lower content of trans fatty acids compared to CS.


CONCLUSIONS
We suggest that LC may exert a dual effect on plasma and hepatic lipid metabolism in an atherogenic animal model. Accordingly, LC, supplemented at 10% in diet, had an anti-atherogenic effect on these apo E-/- mice, and increased fecal lipids, decreased hepatic steatosis, but elevated plasma lipids. Further studies are needed to verify the exact mode of action regarding the complex physiological changes and alteration in lipid metabolism caused by LC.
Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea.
Yun-Young
YY
Cho
Eun-Young
EY
Kwon
Hye-Jin
HJ
Kim
Seon-Min
SM
Jeon
Ki-Teak
KT
Lee
Myung-Sook
MS
Choi
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D050197:Atherosclerosis / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D003314:Corn Oil / Q000737:chemistry*; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004435:Eating; D057075:Enzyme Assays; D005243:Feces / Q000737:chemistry; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009929:Organ Size; D044242:Trans Fatty Acids / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D015430:Weight Gain
D001057:Apolipoproteins E; D004041:Dietary Fats; D044242:Trans Fatty Acids; D003314:Corn Oil
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