Helicobacter pylori infection in relation to gastric cancer progression.
Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad-500 016, India. venkateshwari@yahoo.com
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Venkateshwari
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Krishnaveni
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Venugopal
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P
Shashikumar
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Vidyasagar
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Jyothy
D018450:Disease Progression; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D015994:Incidence; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology*