The role of RhoA/Rho kinase pathway in endothelial dysfunction.
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, USA.
Lin
L
Yao
Maritza J
MJ
Romero
Haroldo A
HA
Toque
Guang
G
Yang
Ruth B
RB
Caldwell
R William
RW
Caldwell
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