The association between dermatomyositis and papillary thyroid cancer: a case report.
We report the case of a 66-year-old woman who developed progressive proximal muscle weakness and papillary thyroid cancer. After a thyroidectomy, she was treated with intravenous methylprednisolone pulse therapy and oral prednisolone followed by tacrolimus therapy. However, her clinical symptoms and laboratory data did not improve sufficiently. Therefore, we administered intravenous immunoglobulin. As a result, she regained substantial muscle strength along with complete normalization of serum muscle enzymes and showed no evidence of recurrence of papillary thyroid cancer or exacerbation of dermatomyositis (DM). Although there is controversy as to whether papillary thyroid cancer is involved in DM, the results of this study support a connection between these two conditions.
Department of Medicine, Division of Neurology, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan. 072r5105@st.kumamoto-u.ac.jp
Tokunori
T
Ikeda
En
E
Kimura
Teruyuki
T
Hirano
Makoto
M
Uchino
D000368:Aged; D002291:Carcinoma, Papillary / Q000150:complications / Q000473:pathology* / Q000601:surgery; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D020551:Pulse Therapy, Drug; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D016896:Treatment Outcome
D005938:Glucocorticoids; D011239:Prednisolone; D008775:Methylprednisolone
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