Menopausal hormone therapy does not influence lung cancer risk: results from the California Teachers Study.
BACKGROUND
Results from studies examining the association between hormone therapy (HT) and lung cancer risk disagree.


METHODS
We examined the associations between HT use and lung cancer risk among 60,592 postmenopausal women enrolled in the prospective California Teachers Study cohort. Between 1995 and 2007, a total of 727 women had a diagnosis of lung cancer. Multivariable Cox proportional hazards regression models were fit using age as the time metric.


RESULTS
No measure of HT use was associated with lung cancer risk (all P(trend) values ≥0.4). In addition, no variations in risk by smoking status (never, ever, former, current), type of HT [estrogen (E)-alone, E + progestin (P) use], type of menopause, or lung cancer histology were observed.


CONCLUSIONS
Our findings do not support an association between HT and lung cancer.


CONCLUSIONS
This large-scale, prospective study, which capitalizes on the detailed hormone use, smoking history, and type of menopause information available within this unique cohort, was unable to find any association between intake of HT and lung cancer risk.
Department of Population Sciences, Division of Cancer Etiology, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA.
Jessica
J
Clague
Peggy
P
Reynolds
Jane
J
Sullivan-Halley
Huiyan
H
Ma
James V
JV
Lacey
Katherine D
KD
Henderson
Giske
G
Ursin
Dee
D
West
Shine
S
Chang
George L
GL
Delclos
Xianglin L
XL
Du
Michele R
MR
Forman
Leslie
L
Bernstein
D002140:California / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D020249:Hormone Replacement Therapy / Q000706:statistics & numerical data*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors
Cancer Causes Control. 2002 Sep;13(7):625-35
12296510
J Womens Health (Larchmt). 2010 Feb;19(2):279-88
20095904
J Clin Oncol. 2007 Feb 10;25(5):561-70
17290066
Chest. 2005 Jul;128(1):370-81
16002959
Maturitas. 2010 Mar;65(3):198-204
20031346