Can left ventricular end-diastolic volumes be estimated with prospective ECG-gated CT coronary angiography?
BACKGROUND
With the goal of minimizing patient radiation exposure, many centres have adopted prospective ECG-gated computed tomographic coronary angiography. Since image acquisition occurs only during ventricular diastasis, the ability to measure left ventricular (LV) ejection fraction (EF) and LV volumes has been lost. Given that LV volumes have prognostic value, the ability to estimate LV end diastolic volume (EDV) may be clinically desirable.


OBJECTIVE
We sought to predict LV EDV using CT coronary angiography (CTA) images obtained during ventricular diastasis.


METHODS
Consecutive patients who underwent retrospective ECG-gated CTA were enrolled. Images were reconstructed at the 75% phase and at end-diastole. LV and left atrial (LA) volumes were measured.


RESULTS
A total of 153 consecutive patients were analyzed (mean age = 56.7 ± 11.2 years; men = 56.2%). The mean LV EDV and EF were 144.4 ± 40.2 mL and 63.4 ± 9.9%, respectively. There appeared to be a very strong linear relationship between the 75% phase LV volume and LV EDV with an R(2) of 0.993. Using LV and LA volumes at the 75% phase, a prediction model of LV EDV was developed (LV EDV = (1.021 × 75% phase LV volume)+(0.259 × 75% phase LA volume), adjusted R(2) = 0.995).


CONCLUSIONS
LV EDV can be estimated using CTA data obtained during ventricular diastasis. Further studies are needed to demonstrate that such estimates of LV EDV have incremental prognostic value over coronary artery disease severity assessment with prospective ECG-gated CTA.
Toronto General Hospital, Department of Medicine, 200 Elizabeth Street, Eaton Building 14-217, Toronto, ON, Canada M5G 2C4. prateek.khatri@utoronto.ca
Prateek J
PJ
Khatri
Vikas
V
Tandon
Li
L
Chen
Yeung
Y
Yam
Benjamin J W
BJ
Chow
D000465:Algorithms; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology