Polymorphisms in interleukin-1B (IL-1B) and interleukin 1 receptor antagonist (IL-1RN) genes associate with gastric cancer risk in the Chinese population.
BACKGROUND
Gastric cancer is one of the most common malignancies afflicting the Chinese population. Polymorphisms in interleukin-1B (IL-1B) and interleukin-1 receptor antagonist (IL-1RN) genes have been associated with increased gastric cancer risk.


OBJECTIVE
A case-control study enrolled 392 gastric cancer patients and 508 healthy were carried out to investigate the association between polymorphisms in IL-1B and IL-1RN and gastric cancer risk.


METHODS
Polymerase chain reaction (PCR)-restriction fragment length polymorphism was used for detection of two potentially functional polymorphisms (IL-1B-31 and IL-1B-511) in the IL-1B gene promoter and PCR was used for detection of the variable tandem repeat in the second intron of IL-1RN.


RESULTS
The data showed that the IL-1B-31CC genotype increased gastric cancer risk to an adjusted odd of 2.27 (95% CI, 1.49-3.46), IL-1B-31CT to 1.48 (95% CI, 1.01-2.16) and IL-1B-31CT/CC to 1.68 (95% CI, 1.17-2.40), while IL-1B-51TT genotype associated with increased gastric cancer risk to an adjusted odd of 2.53 (95% CI, 1.67-3.84), IL-1B-511TC to 1.45 (95% CI, 1.02-2.06), and IL-1B-511TC TT/TC to 1.72 (95% CI, 1.23, 2.39). Furthermore, IL-1RN heterogeneity genotype (IL-1RN2L) was associated with gastric cancer risk to an adjusted odd of 1.70 (95% CI, 1.05-2.74) compared to the wild-type homozygote (IL-1RNLL). In addition, H. pylori infection enhanced gastric cancer risk through these SNPs.


CONCLUSIONS
The data from the current study demonstrated that the genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1RN increased risk of gastric cancer in this Chinese population and the risk was further enhanced by H. pylori.
The Central Laboratory, Nanjing First Hospital Affiliated to Nanjing Medical University, 210006, Nanjing, China. hebangshun@163.com
Bang-Shun
BS
He
Yu-Qin
YQ
Pan
Yong-Fei
YF
Xu
Chan
C
Zhu
Li-Li
LL
Qu
Shu-Kui
SK
Wang
D000428:Alcohol Drinking / Q000453:epidemiology; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D012907:Smoking / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta
Nature. 2001 Jul 5;412(6842):99
11808612
Ann Neurol. 2009 Apr;65(4):470-3
19350673
Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1920-8
17035400
Gastroenterology. 2001 Oct;121(4):823-9
11606496
Gut. 2003 Dec;52(12):1684-9
14633943
Scand J Immunol. 1998 Mar;47(3):195-8
9519856
Cytokine. 2007 May;38(2):96-100
17596959
Am J Med. 2002 Feb 1;112(2):141-3
11835953
Anticancer Res. 2002 Nov-Dec;22(6A):3421-4
12530098
Ann Neurol. 2010 Nov;68(5):768-9; author reply 769-70
21031589
Int J Cancer. 2002 Jul 20;100(3):249-60
12115538
Ann Neurol. 2009 Jan;65(1):76-82
19194882
J Gastroenterol Hepatol. 2007 Feb;22(2):234-9
17295877
J Gastroenterol. 2004;39(5):501-3
15175954
Cytokine Growth Factor Rev. 2002 Dec;13(6):483-502
12401481
Gynecol Oncol. 1999 Jun;73(3):359-61
10366460
Gastroenterology. 1995 Sep;109(3):681-91
7657096
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):635; author reply 635-6
17372270
J Intern Med. 2003 Feb;253(2):102-19
12542550
Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1674-87
16985030
J Natl Cancer Inst. 2003 May 21;95(10):760; author reply 760-1
12759399
Int J Cancer. 2005 Apr 10;114(3):465-71
15551344
Cancer Lett. 2004 Nov 25;215(2):191-8
15488638
J Gastroenterol. 2008;43(9):705-10
18807132
Gastric Cancer. 2006;9(4):284-90
17235630
Nature. 2000 Mar 23;404(6776):398-402
10746728
CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
15761078
Eur J Clin Invest. 1992 Jun;22(6):396-402
1353022
Nature. 2002 Dec 19-26;420(6917):860-7
12490959
Biochem Biophys Res Commun. 2009 Sep 25;387(3):456-60
19607807
Gastroenterology. 2002 Dec;123(6):1793-803
12454835
Int J Cancer. 2007 Feb 1;120(3):552-62
17096351
J Gastroenterol. 2001 Oct;36(10):696-9
11686480
World J Gastroenterol. 2007 Jun 7;13(21):2923-31
17589941
Ann Neurol. 2009 Dec;66(6):771-82
20035514
Clin Infect Dis. 2002 Jan 15;34(2):204-9
11740709
Anim Genet. 2001 Apr;32(2):106-9
11421949
Gastroenterology. 2002 Jul;123(1):92-105
12105837
Am J Gastroenterol. 2006 Feb;101(2):248-54
16454826
J Gastroenterol. 2004;39(5):429-33
15175940