title: The contribution of animal models to the understanding of the host range and virulence of influenza A viruses.
abstract: Since ferrets were first used in 1933 during the initial isolation of influenza A viruses, animal models have been critical for influenza research. The following review discusses the contribution of mice, ferrets, and non-human primates to the study of influenza virus host range and pathogenicity.
authors.affiliation: Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: O'Donnell
authors.forename: Kanta
authors.initials: K
authors.lastname: Subbarao
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005289:Ferrets / Q000821:virology; D058507:Host Specificity; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000472:pathogenicity; D009980:Influenza A virus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D007251:Influenza, Human / Q000503:physiopathology* / Q000821:virology; D051379:Mice / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000503:physiopathology / Q000821:virology; D011323:Primates / Q000821:virology; D014774:Virulence