title: [The risk of necrotizing enterocolitis in newborns with congenital heart disease. a single institution-cohort study].
abstract: OBJECTIVE
  Necrotizing enterocolitis (NEC) is the most common gastrointestinal surgical disease among neonates. Congenital heart disease (CHD) is also a significant cause of infant morbidity and mortality and it is usually associated with prematurity, low birth weight, pulmonary and gastrointestinal disease, conditions that also account for the development of NEC. Our aim is to analyze the incidence and the risk factors for NEC in neonates with CDH admitted to the Neonatal Intensive Care Unit (NICU) in a 6 years period.
  
  
  METHODS
  All patients admitted in the NICU for any type of CDH from January 2003 to December 2008 comprised the cohort of this study. The primary outcome measure was the development of NEC in any stage. Sixteen independent variables were selected to include those factors previously correlated with NEC. Uni and multivariate statistical analysis were performed with SPSS 15.0 for Windows. Relative Risks (RR) are presented with 95% confidence intervals.
  
  
  RESULTS
  935 out of the 7803 neonates admitted during this period, 935 (11.9%) presented a CHD. Among them, 70 also had NEC (RR 8.4-17.8), 31 requiring surgical treatment (Bell stages III and IV). The risk for NEC was specially increased if CHD needed surgical correction (2.1-5.1) and among babies with very low birth weight (VLBW, <1,500 g) (2-4.8). After multivariate analysis the only independent variables associated with an increased risk of NEC were birth weight less than 1,500 g (2.2-7.4), the need of surgical correction of CHD (2.2-7.1) and a clinical picture of septicaemia (1.1-3.9).
  
  
  CONCLUSIONS
  The incidence of NEC is greater in neonates with CDH than in the normal newborn population. Early recognition of NEC should be warranted among CHD patients, specially in those with VLBW, surgical treatment of CHD and sepsis. In this sub-cohort of patients an increased risk of NEC should be suspected.
authors.affiliation: Departamento de Cirugía Pediátrica, Hospital Universitario La Paz, Madrid. carlosgeli@hotmail.com
authors.forename: C A
authors.initials: CA
authors.lastname: De La Torre
authors.forename: M
authors.initials: M
authors.lastname: Miguel
authors.forename: L
authors.initials: L
authors.lastname: Martínez
authors.forename: R
authors.initials: R
authors.lastname: Aguilar
authors.forename: S
authors.initials: S
authors.lastname: Barrena
authors.forename: L
authors.initials: L
authors.lastname: Lassaletta
authors.forename: J A
authors.initials: JA
authors.lastname: Tovar
mesh_terms: D015331:Cohort Studies; D020345:Enterocolitis, Necrotizing / Q000453:epidemiology / Q000209:etiology*; D006331:Heart Diseases / Q000150:complications* / Q000151:congenital*; D006801:Humans; D007231:Infant, Newborn; D012189:Retrospective Studies; D012307:Risk Factors