title: Seasonal variations of Substance P in the striatum of the female rat are affected by maternal and offspring pinealectomy.
abstract: The effect of pinealectomy (PIN-X) and PIN-X+melatonin treatment during pregnancy (PIN-X+MEL) 100μg/100g body weight on Substance P (SP) in the striatum was investigated in offspring female rats. Female offspring were divided into control and PIN-X at the neonatal period, and studied at days 31 and 60. PIN-X mother/control offspring showed a positive influence on striatal SP values in winter, at both ages and in spring at day 31. However, this effect of maternal PIN-X was not observed in summer or fall. The effect of PIN-X on the offspring showed a positive effect in spring at day 31 and summer at the two ages studied. This effect was not observed in fall or winter. Two generations, PIN-X mother/PIN-X offspring, altered the effect of mother or offspring PIN-X and decreased the SP values in winter, spring and summer. Only striatal SP at day 60 in fall was increased. In two generations PIN-X, the striatal SP values were similar to those observed in control mother/control offspring. The effect of PIN-X+MEL treatment on mothers during pregnancy was inhibitory for the intact offspring and stimulatory for PIN-X offspring. In conclusion, the results indicate that maternal and offspring PIN-X seem to exert a rotative and positive seasonal influence from winter to spring to summer. Two generations PIN-X disrupted this rotative circuit and in fall a compensatory discharge of SP was observed.
authors.affiliation: Departamento de Biología Funcional, Área Fisiología, Facultad de Medicina, Universidad de Oviedo, C/Julián Clavería No. 6, 33006 Oviedo, Asturias, Spain. beatrizd@uniovi.es
authors.forename: E
authors.initials: E
authors.lastname: Díaz
authors.forename: N
authors.initials: N
authors.lastname: Vázquez
authors.forename: C
authors.initials: C
authors.lastname: Fernández
authors.forename: D
authors.initials: D
authors.lastname: Durand
authors.forename: M
authors.initials: M
authors.lastname: Lasaga
authors.forename: L
authors.initials: L
authors.lastname: Debeljuk
authors.forename: B
authors.initials: B
authors.lastname: Díaz
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003342:Corpus Striatum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology / Q000601:surgery*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D012621:Seasons; D013373:Substance P / Q000378:metabolism*
chemical_list: D013373:Substance P; D008550:Melatonin