title: The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly.
abstract: This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.
authors.affiliation: Laboratory of Clinical Pharmacology Q7642, Rigshospitalet, Copenhagen, Denmark. kasper.broedbaek@rh.regionh.dk
authors.forename: Kasper
authors.initials: K
authors.lastname: Broedbaek
authors.forename: Volkert
authors.initials: V
authors.lastname: Siersma
authors.forename: Jon T
authors.initials: JT
authors.lastname: Andersen
authors.forename: Morten
authors.initials: M
authors.lastname: Petersen
authors.forename: Shoaib
authors.initials: S
authors.lastname: Afzal
authors.forename: Brian
authors.initials: B
authors.lastname: Hjelvang
authors.forename: Allan
authors.initials: A
authors.lastname: Weimann
authors.forename: Richard D
authors.initials: RD
authors.lastname: Semba
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Henrik E
authors.initials: HE
authors.lastname: Poulsen
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D005293:Ferritins / Q000032:analysis; D006151:Guanosine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000378:metabolism*; D019266:Iron, Dietary / Q000378:metabolism; D007558:Italy; D008297:Male; D009696:Nucleic Acids / Q000652:urine*; D010084:Oxidation-Reduction; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D019266:Iron, Dietary; D009696:Nucleic Acids; D006151:Guanosine; C046215:8-hydroxyguanosine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron; D003849:Deoxyguanosine