title: [Asthma: new insights and advances in treatment].
abstract: In mild asthma low-dose steroid inhalation treatment reduces severe exacerbations and exacerbation associated loss of lung function. In patients with mild asthma, symptom-driven use of a combination of inhaled steroid and short-acting beta-2-sympathomimetics in a single inhaler is feasible. In moderate and severe asthma the fixed combination of formoterol and budesonide can be used a maintenance therapy but also as treatment of acute symptoms. Monotherapy with long-acting beta 2-sympathomimetics should be completely avoided. Long-acting anticholinergic drugs are equally efficacious as long-acting beta-2-sympathomimetics, but have not yet been approved for use in patients with asthma. The correct identification of various phenotypes is especially important in severe asthma, because there are different specific treatment approaches.
authors.affiliation: III. Medizinische Klinik, Johannes-Gutenberg-Universität, Mainz.
authors.forename: I
authors.initials: I
authors.lastname: Haasler
authors.forename: R
authors.initials: R
authors.lastname: Buhl
authors.forename: C
authors.initials: C
authors.lastname: Taube
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage*; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D001249:Asthma / Q000145:classification / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide / Q000008:administration & dosage; D018680:Cholinergic Antagonists / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000008:administration & dosage; D005240:Feasibility Studies; D000068759:Formoterol Fumarate; D006801:Humans; D008134:Long-Term Care; D012129:Respiratory Function Tests
chemical_list: D000305:Adrenal Cortex Hormones; D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents; D018680:Cholinergic Antagonists; D003692:Delayed-Action Preparations; D004983:Ethanolamines; D019819:Budesonide; D000068759:Formoterol Fumarate