title: Antithymocyte globulin-induced acute lung injury during transplantation for aplastic anemia.
abstract: A 10-year-old boy with acquired, very severe aplastic anemia developed acute lung injury after the administration of equine antithymocyte globulin, during conditioning for allogenic bone marrow transplantation. Limited cases of antithymocyte globulin-induced acute lung injury have been described in adults. The respiratory worsening was sudden and required mechanical ventilation. The clinical course was complicated by sepsis with Escherichia coli, vancomycin-resistant enterococci, and Stenotrophomonas maltophilia. Implications for treatment are discussed and earlier literature is reviewed.
authors.affiliation: Hematology/Oncology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Sapna
authors.initials: S
authors.lastname: Oberoi
authors.forename: Deepak
authors.initials: D
authors.lastname: Bansal
authors.forename: Ratti Ram
authors.initials: RR
authors.lastname: Sharma
authors.forename: Vikas
authors.initials: V
authors.lastname: Gautam
authors.forename: Neelam
authors.initials: N
authors.lastname: Marwaha
authors.forename: Ram Kumar
authors.initials: RK
authors.lastname: Marwaha
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced* / Q000503:physiopathology; D000741:Anemia, Aplastic / Q000601:surgery*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000961:Antilymphocyte Serum / Q000009:adverse effects*; D001424:Bacterial Infections / Q000150:complications; D016026:Bone Marrow Transplantation; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D006736:Horses; D006801:Humans; D008297:Male; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010878:Piperacillin / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination; D018805:Sepsis / Q000150:complications; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014640:Vancomycin / Q000627:therapeutic use; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000961:Antilymphocyte Serum; D000077725:Piperacillin, Tazobactam Drug Combination; D014640:Vancomycin; D010397:Penicillanic Acid; D003520:Cyclophosphamide; D014740:Vidarabine; C024352:fludarabine; D010878:Piperacillin