title: A cluster of pediatric endemic typhus cases in Orange County, California.
abstract: Murine typhus is typically a mild febrile illness caused by Rickettsia typhi, generally conﬁned to Texas and Southern California. Clinicians should consider early treatment with doxycycline when presented with a child having protracted fever, rash, and headache.We present 5 pediatric cases and a literature review highlighting the changing epidemiology and diagnostic difﬁculty of typhus.
authors.affiliation: Academic Affairs and †Infectious Disease, Children’sHospital of Orange County, Orange, CA 92686,USA. jgreen@choc.org
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Green
authors.forename: Jasjit
authors.initials: J
authors.lastname: Singh
authors.forename: Michele
authors.initials: M
authors.lastname: Cheung
authors.forename: Felice C
authors.initials: FC
authors.lastname: Adler
authors.forename: Negar
authors.initials: N
authors.lastname: Ashouri
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002140:California / Q000453:epidemiology; D002675:Child, Preschool; D016000:Cluster Analysis; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D012286:Rickettsia typhi / Q000302:isolation & purification*; D014437:Typhus, Endemic Flea-Borne / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline