title: [No association of K469E polymorphism of intercellular adhesion molecule-1 with rheumatoid arthritis].
abstract: OBJECTIVE
  To investigate the association of the intercellular adhesion molecule-1 gene (ICAM-1) K469E polymorphism and rheumatoid arthritis (RA).
  
  
  METHODS
  Two hundred and seventy-five patients with RA and 254 healthy individuals were collected and enrolled in the study. The K469E polymorphism of ICAM-1 gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  The genotype frequencies of KK, KE and EE of K469E polymorphism were 0.535,0.411 and 0.054 respectively in the RA patients, and 0.512,0.437 and 0.051 respectively in the healthy individuals, and there was no significant difference between the two groups (chi² = 0.371, P = 0.831). The frequencies of the K469 allele were 0.74 and 0.73 in the RA patients and the controls respectively (chi² = 0.127, P = 0.721, OR = 1.051, 95%CI:0.800-1.381). No significant difference was observed in KK + KE genotype frequencies between the two groups (P = 0.863), with an odds ratio of 0.935 (95%CI:0.436-2.005).
  
  
  CONCLUSIONS
  The K469E polymorphism of the ICAM-1 gene was not associated with the susceptibility of rheumatoid arthritis.
authors.affiliation: Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province, Affiliated Hospital of Wenzhou Medical College, Taizhou, Zhejiang, 317000 PR China.
authors.forename: Zhao-lin
authors.initials: ZL
authors.lastname: Yuan
authors.forename: Xiao-xue
authors.initials: XX
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Jian-xin
authors.initials: JX
authors.lastname: Lv
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D018799:Intercellular Adhesion Molecule-1