title: Dielectric studies of the paracetamol-lenticular tissue interactions.
abstract: This paper reports on the effect of paracetamol on the dielectric behavior of the rabbit lens. Measurements were performed over the frequency range of 100 Hz-100 kHz in air and at the temperature of 35°C. The frequency dependencies of the relative permittivity and dielectric loss for the control and paracetamol-control lenses are described in terms of a power-low, Debye and Cole-Cole relations. The effect of paracetamol on the dielectric properties of the lens is visible in the lower values of the relative permittivity than those for the control sample at the same frequency. In addition, the relaxations around 18 and 46 kHz for the paracetamol-control lens are shifted to lower frequencies compared with the control lens. The results of this work indicate that the present method is useful in detection of the lens toxicity elicited by overdoses of paracetamol in animal.
authors.affiliation: Department of Biophysics, Poznań University of Medical Sciences, Poznań, Poland. ewaklcde@amu.edu.pl
authors.forename: E
authors.initials: E
authors.lastname: Marzec
authors.forename: J
authors.initials: J
authors.lastname: Olszewski
authors.forename: E
authors.initials: E
authors.lastname: Grześkowiak
authors.forename: A
authors.initials: A
authors.lastname: Kamińska
authors.forename: A
authors.initials: A
authors.lastname: Bienert
authors.forename: K
authors.initials: K
authors.lastname: Iwanik
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D017097:Electric Impedance; D007908:Lens, Crystalline / Q000187:drug effects*; D008297:Male; D011817:Rabbits
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen