title: Fronto-limbic dysfunction in borderline personality disorder: a 18F-FDG positron emission tomography study.
abstract: BACKGROUND
  Several functional neuroimaging studies have demonstrated abnormalities in fronto-limbic pathways when comparing borderline personality disorder (BPD) patients with controls. The present study aimed to evaluate regional cerebral metabolism in euthymic BPD patients with similar measured impulsivity levels by means of 18F-FDG PET during resting state and to compare them against a control group.
  
  
  METHODS
  The present study evaluates regional cerebral metabolism in 8 euthymic BPD patients with 18F-FDG PET during resting state as compared to 8 controls with similar socio-geographic characteristics.
  
  
  RESULTS
  BPD patients presented a marked hypo-metabolism in frontal lobe and showed hyper-metabolism in motor cortex (paracentral lobules and post-central cortex), medial and anterior cingulus, occipital lobe, temporal pole, left superior parietal gyrus and right superior frontal gyrus. No significant differences appeared in basal ganglia or thalamus.
  
  
  CONCLUSIONS
  Results reveal a dysfunction in patients' frontolimbic network during rest and provide further evidence for the importance of these regions in relation to BPD symptomatology.
authors.affiliation: Borderline Personality Disorder Institute, Psychiatry Department, Capio Hospital General de Catalunya, Sant Cugat del Vallès, Barcelona, Spain. 36776jsj@comb.cat
authors.forename: José
authors.initials: J
authors.lastname: Salavert
authors.forename: Miquel
authors.initials: M
authors.lastname: Gasol
authors.forename: Eduard
authors.initials: E
authors.lastname: Vieta
authors.forename: Ana
authors.initials: A
authors.lastname: Cervantes
authors.forename: Carlos
authors.initials: C
authors.lastname: Trampal
authors.forename: Juan Domingo
authors.initials: JD
authors.lastname: Gispert
mesh_terms: D000328:Adult; D000679:Amygdala / Q000378:metabolism; D001883:Borderline Personality Disorder / Q000378:metabolism*; D016022:Case-Control Studies; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000378:metabolism; D006801:Humans; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000378:metabolism; D009778:Occipital Lobe / Q000378:metabolism; D010296:Parietal Lobe / Q000378:metabolism; D049268:Positron-Emission Tomography; D013702:Temporal Lobe / Q000378:metabolism; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18