title: Dietary cocoa butter or refined olive oil does not alter postprandial hsCRP and IL-6 concentrations in healthy women.
abstract: Contrary to other long chain saturated fatty acids (SFA), fats high in stearic acid do not raise plasma cholesterol concentrations, however, a slight elevation in inflammatory markers, plasma fibrinogen and interleukin-6 (IL-6), has been observed in the fasting state. The effect of stearic acid on inflammation in the postprandial state has not yet been reported. We conducted a single blind crossover, randomized, postprandial study to compare the effects of a fat load of cocoa butter high in stearic acid and olive oil in ten healthy women. The test meals contained 1 g of fat per kg body weight (mean 62 g). Blood samples were collected at 0 (fasting), 4 and 6 h. Both diets resulted in a significant increase in serum triacylglycerol (TAG) concentration over time (P = 0.003) and a decrease in serum IL-6 concentration after 4 h followed by an increase to post absorptive values after 6 h (P < 0.001); whereas serum high sensitivity C-reactive protein (hsCRP) concentration was not affected. There was no difference between diets in effects on serum TAG, hsCRP and IL-6 concentrations and no association between postprandial lipemia and inflammatory markers. High intake of dietary fats increase postprandial serum TAG, however, may not affect inflammatory markers postprandially. Thus, fat rich in stearic acid does not seem to increase postprandial inflammation.
authors.affiliation: Department of Human Nutrition, Faculty of Life Sciences, Copenhagen University, Frederiksberg, Denmark. tth@life.ku.dk
authors.forename: Tine
authors.initials: T
authors.lastname: Tholstrup
authors.forename: Kim-Tiu
authors.initials: KT
authors.lastname: Teng
authors.forename: Marianne
authors.initials: M
authors.lastname: Raff
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D005215:Fasting; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage*; D019518:Postprandial Period; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D015850:Interleukin-6; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; C052387:cocoa butter; D002097:C-Reactive Protein