title: Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort.
abstract: Mitochondrial haplogroups could influence individual susceptibility to mitochondrial DNA (mtDNA) damage, and human longevity, as indicated by previous studies with Caucasian (European) or Asian cohorts. Here, we compared the frequency of mtDNA haplogroups in a group of Spanish (Caucasian) centenarians (n = 65, aged 100-108 years, 58 women, most from the central part of Spain) and a group of healthy young adults (n = 138, 62 women, aged 20-40 years) of the same ethnic origin. We did not find significant differences between centenarians and the control group (P > 0.2). Only two centenarians (both women) had the haplogroup J, which hampered comparison with the control group (n = 15, five women). Our data confirm that the potential effects of mitochondrial haplogroups on human longevity might be population/geographic specific, with important differences between studies (notably, with regard to the previously reported potential benefit brought about by the haplogroup J) arising from the different living environment and ethnic background of the study cohorts.
authors.affiliation: Departament de Patología Mitocondrial i Neuromuscular, Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, Spain.
authors.forename: Tomàs
authors.initials: T
authors.lastname: Pinós
authors.forename: Gisela
authors.initials: G
authors.lastname: Nogales-Gadea
authors.forename: Jonatan R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rodríguez-Romo
authors.forename: Catalina
authors.initials: C
authors.lastname: Santiago-Dorrego
authors.forename: Carmen
authors.initials: C
authors.lastname: Fiuza-Luces
authors.forename: Félix
authors.initials: F
authors.lastname: Gómez-Gallego
authors.forename: Amalia
authors.initials: A
authors.lastname: Cano-Nieto
authors.forename: Nuria
authors.initials: N
authors.lastname: Garatachea
authors.forename: María
authors.initials: M
authors.lastname: Morán
authors.forename: Miguel
authors.initials: M
authors.lastname: Angel Martín
authors.forename: Joaquín
authors.initials: J
authors.lastname: Arenas
authors.forename: Antoni L
authors.initials: AL
authors.lastname: Andreu
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000465:Algorithms; D016022:Case-Control Studies; D015331:Cohort Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D013030:Spain
chemical_list: D004272:DNA, Mitochondrial