title: A randomized clinical study to assess the extrinsic staining profiles of stannous- and triclosan-containing dentifrices.
abstract: OBJECTIVE
  To evaluate the extrinsic stain profiles of two experimental stannous-containing dentifrice prototypes compared to two marketed control dentifrices.
  
  
  METHODS
  This was a 5-week, randomized, four-treatment, parallel group, double-blind clinical trial of healthy adults. Following a baseline Lobene Stain Index evaluation, subjects received a prophylaxis limited to the 12 anterior teeth to remove surface stain and calculus. They were randomly assigned based on stain scores to one of the four treatment groups: one of two experimental stannous-containing sodium fluoride dentifrices; a non-staining marketed triclosan dentifrice (Colgate Total); or a 0.454% stannous fluoride dentifrice (Crest Gum Care). Subjects brushed for 1 minute twice daily at home with their assigned dentifrice. Stain examinations were repeated at Week 3 and Week 5 to assess treatment differences.
  
  
  RESULTS
  For the 96 subjects completing the study, Lobene stain composite mean scores--as well as extent (area) and intensity average scores--were significantly lower in the two experimental stannous-containing dentifrice groups and the Colgate Total group when compared to Crest Gum Care (P < 0.0001) at both Weeks 3 and 5. There were no statistically significant differences (P > 0.145) in stain accumulation at either time point between the experimental stannous groups and the Colgate Total group by any Lobene stain measure (composite, extent, intensity). All dentifrices were well-tolerated.
authors.affiliation: Procter & Gamble Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. he.t@pg.com
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: John M
authors.initials: JM
authors.lastname: Dunavent
authors.forename: Susan K
authors.initials: SK
authors.lastname: Fiedler
authors.forename: Robert A
authors.initials: RA
authors.lastname: Baker
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000627:therapeutic use; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use; D008875:Middle Aged; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D011145:Polyvinyls / Q000627:therapeutic use; D012824:Silicic Acid / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D017971:Tin Compounds / Q000627:therapeutic use; D014002:Tin Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D014075:Tooth Discoloration / Q000188:drug therapy*; D014100:Toothpastes / Q000627:therapeutic use; D014260:Triclosan / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; C098421:Crest Gum Care; C510825:Crest Pro-Health Dentifrice; D003802:Dentifrices; D008298:Maleates; D010710:Phosphates; D011145:Polyvinyls; D017971:Tin Compounds; D014002:Tin Fluorides; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D012824:Silicic Acid; C023599:stannous chloride; D014260:Triclosan; D012969:Sodium Fluoride