title: Comparison of changes of body water measured by using bioelectrical impedance analysis between lercanidipine and amlodipine therapy in hypertensive outpatients.
abstract: OBJECTIVE
  To compare changes of body water measured by using bioelectrical impedance analysis (BIA), between lercanidipine and amlodipine therapy.
  
  
  METHODS
  This is a prospective randomized open-label study in hypertensive outpatients. Eighty patients were randomized into two groups; 1) amlodipine 5 mg/d and 2) lercanidipine 10 mg/d. Patients were assessed for changes in total body water (TBW), extracellular water (ECW) and intracellular water (ICW) at week 4 and 8 after treatment.
  
  
  RESULTS
  At baseline body water in both groups were similar. After treatment, both groups did not have significant changes in body water from baseline. Seven patients in amlodipine group (17.5%) and none of lercanidipine group developed edema; p = 0.012. Among those seven patients, TBW, ECW and ICW all increased significantly from baseline.
  
  
  CONCLUSIONS
  BIA did not detected changes of body water in most patients. However, in patients who developed edema, TBW, ECW and LCW significantly increased from baseline with the greatest changes seen in extracellular compartment.
authors.affiliation: Cardiology Unit, Department of Internal Medicine, Phramongkutklao Hospital, Bangkok, Thailand. dr_nakarin@hotmail.com
authors.forename: Nakarin
authors.initials: N
authors.lastname: Sansanayudh
authors.forename: Supakit
authors.initials: S
authors.lastname: Wongwiwatthananukit
authors.forename: Siriluck
authors.initials: S
authors.lastname: Veerayuthvilai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001823:Body Composition; D001834:Body Water; D004095:Dihydropyridines / Q000627:therapeutic use*; D004487:Edema / Q000209:etiology; D017097:Electric Impedance; D045604:Extracellular Fluid; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007424:Intracellular Fluid; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011446:Prospective Studies; D013785:Thailand; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004095:Dihydropyridines; D017311:Amlodipine; C060343:lercanidipine