title: Oseltamivir-resistant pandemic (H1N1) 2009 virus, Mexico.
abstract: During May 2009-April 2010, we analyzed 692 samples of pandemic (H1N1) 2009 virus from patients in Mexico. We detected the H275Y substitution of the neuraminidase gene in a specimen from an infant with pandemic (H1N1) 2009 who was treated with oseltamivir. This virus was susceptible to zanamivir and resistant to adamantanes and oseltamivir.
authors.affiliation: Instituto de Diagnostico y Referencia Epidemiologicos, Mexico City, Mexico.
authors.forename: José Ernesto
authors.initials: JE
authors.lastname: Ramirez-Gonzalez
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Gonzalez-Duran
authors.forename: Patricia
authors.initials: P
authors.lastname: Alcantara-Perez
authors.forename: Claudia
authors.initials: C
authors.lastname: Wong-Arambula
authors.forename: Hiram
authors.initials: H
authors.lastname: Olivera-Diaz
authors.forename: Iliana
authors.initials: I
authors.lastname: Cortez-Ortiz
authors.forename: Gisela
authors.initials: G
authors.lastname: Barrera-Badillo
authors.forename: Ha
authors.initials: H
authors.lastname: Nguyen
authors.forename: Larisa
authors.initials: L
authors.lastname: Gubareva
authors.forename: Irma
authors.initials: I
authors.lastname: Lopez-Martinez
authors.forename: Jose Alberto
authors.initials: JA
authors.lastname: Díaz-Quiñonez
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Lezana-Fernández
authors.forename: Hugo Lopez
authors.initials: HL
authors.lastname: Gatell-Ramírez
authors.forename: Jose Angel
authors.initials: JA
authors.lastname: Cordova Villalobos
authors.forename: Mauricio
authors.initials: M
authors.lastname: Hernández-Avila
authors.forename: Celia
authors.initials: C
authors.lastname: Alpuche-Aranda
mesh_terms: D000218:Adamantane / Q000494:pharmacology; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D008800:Mexico / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000235:genetics; D053139:Oseltamivir / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D058873:Pandemics; D017354:Point Mutation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D053243:Zanamivir / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir; D000218:Adamantane