title: A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission.
abstract: We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.
authors.affiliation: Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University, Japan. yusuke0225@dance.ocn.ne.jp
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sakamaki
authors.forename: Matsuhiko
authors.initials: M
authors.lastname: Hayashi
authors.forename: Shu
authors.initials: S
authors.lastname: Wakino
authors.forename: Seiichi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Kounosuke
authors.initials: K
authors.lastname: Konishi
authors.forename: Akinori
authors.initials: A
authors.lastname: Hashiguchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000368:Aged; D001706:Biopsy; D015897:Comorbidity; D016572:Cyclosporine / Q000627:therapeutic use*; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000503:physiopathology; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D011507:Proteinuria / Q000188:drug therapy; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine