title: Autoinflammatory diseases and cardiovascular manifestations.
abstract: Abstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by mutations in the TNFRSF1A gene. Pericardial diseases are the most represented cardiovascular abnormalities, though the role of MEFV and TNFRSF1A in the initiation of heart involvement has not been demonstrated formally and will be discussed herein.
authors.affiliation: Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Rome, Italy. drigante@gmail.com
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Luca
authors.initials: L
authors.lastname: Cantarini
authors.forename: Massimo
authors.initials: M
authors.lastname: Imazio
authors.forename: Orso Maria
authors.initials: OM
authors.lastname: Lucherini
authors.forename: Emanuela
authors.initials: E
authors.lastname: Sacco
authors.forename: Mauro
authors.initials: M
authors.lastname: Galeazzi
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Brizi
authors.forename: Antonio
authors.initials: A
authors.lastname: Brucato
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D003598:Cytoskeletal Proteins / Q000235:genetics; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D005334:Fever; D056660:Hereditary Autoinflammatory Diseases / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D010493:Pericarditis / Q000209:etiology / Q000503:physiopathology; D000071198:Pyrin; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D047888:Receptors, Tumor Necrosis Factor, Type I; C506235:TNFRSF1A protein, human