title: The C60-fullerene porphyrin adducts for prevention of the doxorubicin-induced acute cardiotoxicity in rat myocardial cells.
abstract: This is a fullerene-based low toxic nanocationite designed for targeted delivery of the paramagnetic stable isotope of magnesium to the doxorubicin (DXR)-induced damaged heart muscle providing a prominent effect close to about 80% recovery of the tissue hypoxia symptoms in less than 24 hrs after a single injection (0.03 - 0.1 LD50). Magnesium magnetic isotope effect selectively stimulates the ATP formation in the oxygen-depleted cells due to a creatine kinase (CK) and mitochondrial respiratory chain-focusing "attack" of 25Mg2+ released by nanoparticles. These "smart nanoparticles" with membranotropic properties release the overactivating cations only in response to the intracellular acidosis. The resulting positive changes in the energy metabolism of heart cell may help to prevent local myocardial hypoxic (ischemic) disorders and, hence, to protect the heart muscle from a serious damage in a vast variety of the hypoxia-induced clinical situations including DXR side effects.
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Pharmacy & Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Vahid
authors.initials: SV
authors.lastname: Shetab Boushehri
authors.forename: Seyed Nasser
authors.initials: SN
authors.lastname: Ostad
authors.forename: Saeed
authors.initials: S
authors.lastname: Sarkar
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Kuznetsov
authors.forename: Anatoly L
authors.initials: AL
authors.lastname: Buchachenko
authors.forename: Marina A
authors.initials: MA
authors.lastname: Orlova
authors.forename: Bagher
authors.initials: B
authors.lastname: Minaii
authors.forename: Abbas
authors.initials: A
authors.lastname: Kebriaeezadeh
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Rezayat
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D002264:Carboxylic Acids / Q000737:chemistry*; D015687:Cell Hypoxia; D003402:Creatine Kinase / Q000378:metabolism; D019610:Cytoprotection; D004317:Doxorubicin / Q000633:toxicity*; D004337:Drug Carriers; D004734:Energy Metabolism / Q000187:drug effects; D037741:Fullerenes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007928:Lethal Dose 50; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D053768:Metal Nanoparticles; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010101:Oxygen Consumption / Q000187:drug effects; D011166:Porphyrins / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic; C416673:C60 carboxyfullerene; D002264:Carboxylic Acids; D004337:Drug Carriers; D037741:Fullerenes; D011166:Porphyrins; D004317:Doxorubicin; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D008274:Magnesium