title: Switching to black rice diets modulates low-density lipoprotein oxidation and lipid measurements in rabbits.
abstract: The effect of white and black rice consumption on lipid profile, hydroperoxides, thiobarbituric reactive substances and oxidized low-density lipoprotein (LDL) induced by hypercholesterolemia was investigated in 24 male rabbits; a purified normal diet (NC, n = 6), a high fat/cholesterol (1.0 g/100 g) diet (PC group, n = 6), a high fat/cholesterol diet with 25 g/100 g white ground rice (PCWR group, n = 6), 25 g/100 g black ground rice (PCBR group, n = 6) for 10 weeks. Blood samples were collected for lipid measurements. Results indicate that serum high-density lipoprotein-cholesterol was higher (P < 0.05) in the PCBR compared with the PC and PCWR groups. Hydroperoxides and thiobarbituric reactive substances were significantly lower (P < 0.05) in the PCBR compared with PCWR and PC groups. Cyanidin-3-glucoside (Cy-3-Glu) and peonidin-3-glucoside have been tested in vitro against copper-mediated low-density lipoprotein. Cy-3-Glu was excelled peonidin-3-glucoside by increasing the lag time of NC from 80 to 500 minutes in the presence of 2.0 μM of Cy-3-Glu. Hierarchically, black rice rabbits group was given the best results compared with other groups. The results may be indicating to a suggested mechanism (anthocyanins protection; Cy-3-Glu) of the cardioprotective effect of black rice.
authors.affiliation: Nutrition and Food Science Department, Faculty of Home Economics, Helwan University, Ain Helwan, Egypt. alymoemin@hotmail.com
authors.forename: Aly R
authors.initials: AR
authors.lastname: Abdel-Moemin
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology; D002791:Cholesterol, Dietary / Q000494:pharmacology; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D023421:Models, Animal; D012275:Oryza / Q000378:metabolism*; D010084:Oxidation-Reduction; D011817:Rabbits / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005960:Glucosides; D008054:Lipid Peroxides; D008055:Lipids; D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances; C462279:cyanidin-3-O-beta-glucopyranoside; C099252:oxidized low density lipoprotein; C480521:peonidin 3-glucoside