title: The mitochondrial permeability transition pore and cyclophilin D in cardioprotection.
abstract: Mitochondria play a central role in heart energy metabolism and Ca(2+) homeostasis and are involved in the pathogenesis of many forms of heart disease. The body of knowledge on mitochondrial pathophysiology in living cells and organs is increasing, and so is the interest in mitochondria as potential targets for cardioprotection. This critical review will focus on the permeability transition pore (PTP) and its regulation by cyclophilin (CyP) D as effectors of endogenous protective mechanisms and as potential drug targets. The complexity of the regulatory interactions underlying control of mitochondrial function in vivo is beginning to emerge, and although apparently contradictory findings still exist we believe that the network of regulatory protein interactions involving the PTP and CyPs in physiology and pathology will increase our repertoire for therapeutic interventions in heart disease. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.
authors.affiliation: Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, 35121 Padova, Italy. dilisa@bio.unipd.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Di Lisa
authors.forename: Andrea
authors.initials: A
authors.lastname: Carpi
authors.forename: Valentina
authors.initials: V
authors.lastname: Giorgio
authors.forename: Paolo
authors.initials: P
authors.lastname: Bernardi
mesh_terms: D000818:Animals; D002118:Calcium; D002316:Cardiotonic Agents / Q000378:metabolism; D016923:Cell Death; D021984:Cyclophilin A / Q000378:metabolism; D000081406:Peptidyl-Prolyl Isomerase F; D021983:Cyclophilins / Q000378:metabolism*; D004734:Energy Metabolism; D006331:Heart Diseases / Q000188:drug therapy; D006801:Humans; D051379:Mice; D008929:Mitochondria, Heart / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D000083162:Mitochondrial Permeability Transition Pore; D015428:Myocardial Reperfusion Injury / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D002316:Cardiotonic Agents; D000081406:Peptidyl-Prolyl Isomerase F; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; C000631446:PPIF protein, mouse; D017382:Reactive Oxygen Species; D021984:Cyclophilin A; D021983:Cyclophilins; D002118:Calcium