title: Non-invasive predictors of human cortical bone mechanical properties: T(2)-discriminated H NMR compared with high resolution X-ray.
abstract: Recent advancements in magnetic resonance imaging (MRI) have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. To this end, (1)H nuclear magnetic resonance (NMR) and high-resolution X-ray signals from human cortical bone samples were correlated with mechanical properties of bone. Results showed that (1)H NMR signals were better predictors of yield stress, peak stress, and pre-yield toughness than were the X-ray derived signals. These (1)H NMR signals can, in principle, be extracted from clinical MRI, thus offering the potential for improved clinical assessment of fracture risk.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: R Adam
authors.initials: RA
authors.lastname: Horch
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Gochberg
authors.forename: Jeffry S
authors.initials: JS
authors.lastname: Nyman
authors.forename: Mark D
authors.initials: MD
authors.lastname: Does
mesh_terms: D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology*; D050723:Fractures, Bone / Q000175:diagnosis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards; D011237:Predictive Value of Tests; D011859:Radiography; D013314:Stress, Mechanical; D013718:Tensile Strength; D014965:X-Rays