title: A convenient synthesis of the side chain of loteprednol etabonate--an ocular soft corticosteroid from 20-oxopregnanes using metal-mediated halogenation as a key reaction.
abstract: A facile synthesis of the side chain of loteprednol etabonate, namely, chloromethyl-17α-[(ethoxycarbonyl))oxy]-11β-hydro of loteprednol etabonate, viz., chloromethyl-17α-[(ethoxycarbonyl))oxy]-11xy-3-oxoandrosta-1,4-diene-17β-carboxylate--an ocular soft corticosteroid, has been described starting from a 20-oxopregnane, namely, 3β-acetoxy-pregn-5(6),16(17)-diene-20-one (16-dehydropregnenolone acetate, i.e., 16-DPA) using our recently developed metal-mediated halogenation as a key reaction.
authors.affiliation: Natural Products Chemistry Division, North East Institute of Science & Technology, Jorhat 785 006, Assam, India. pritishchowdhury@yahoo.com
authors.forename: Pritish
authors.initials: P
authors.lastname: Chowdhury
authors.forename: Juri Moni
authors.initials: JM
authors.lastname: Borah
authors.forename: Papori
authors.initials: P
authors.lastname: Goswami
authors.forename: Archana Moni
authors.initials: AM
authors.lastname: Das
mesh_terms: D000305:Adrenal Cortex Hormones; D000730:Androstadienes / Q000138:chemical synthesis*; D018926:Anti-Allergic Agents; D054879:Halogenation; D000069559:Loteprednol Etabonate; D008670:Metals; D055096:Optical Devices; D011278:Pregnanes / Q000737:chemistry*
chemical_list: D000305:Adrenal Cortex Hormones; D000730:Androstadienes; D018926:Anti-Allergic Agents; D008670:Metals; D011278:Pregnanes; D000069559:Loteprednol Etabonate