title: Intracortical infarcts in small vessel disease: a combined 7-T postmortem MRI and neuropathological case study in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
abstract: OBJECTIVE
  The purpose of this study was to report the detection of infarcts of the cerebral cortex in a patient with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) using high-resolution postmortem 7-T MRI in association with pathological examination.
  
  
  METHODS
  Whole brain high-resolution MRI data were obtained postmortem at 7 T in a 53-year-old patient with CADASIL. These MRI data were used to guide the neuropathological examination of the cortex.
  
  
  RESULTS
  Combined with neuropathology, MRI allowed the delineation of intracortical infarcts confirmed by histological examination in this case. These lesions were not visible on the last in vivo MRI obtained at 1.5 T and were difficult to detect on neuropathological examination only.
  
  
  CONCLUSIONS
  Postmortem high-resolution MRI may help to detect intracortical infarcts in CADASIL and possibly in other small vessel diseases of the brain.
authors.affiliation: Department of Neurology, CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Jouvent
authors.forename: Cyril
authors.initials: C
authors.lastname: Poupon
authors.forename: Françoise
authors.initials: F
authors.lastname: Gray
authors.forename: Claire
authors.initials: C
authors.lastname: Paquet
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
authors.forename: Denis
authors.initials: D
authors.lastname: Le Bihan
authors.forename: Hugues
authors.initials: H
authors.lastname: Chabriat
mesh_terms: D046589:CADASIL / Q000150:complications / Q000473:pathology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology*; D002544:Cerebral Infarction / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D056784:Leukoencephalopathies / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged