title: [Nosocomial pneumonia. Prevention and diagnostic].
abstract: Pneumonia occurring more than 48 h after induction of mechanical ventilation is called ventilator-associated pneumonia (VAP). VAP is the most common nosocomial infection in intensive care medicine and is associated with prolonged intensive care and hospital stay and a higher mortality. The main pathomechanism for development of ventilator-associated pneumonia is not so much the mechanical ventilation per se but more the pathogens passing along the tube towards the lungs. Avoidance of tracheal intubation, strict hygienic measures, reduction of oropharyngeal colonization and the avoidance of microaspiration are the most promising prevention strategies. Therapeutic success in treatment of VAP is coupled to an early diagnosis and therapy. Suspicion of pneumonia is based on clinical and radiologic criteria. Biomarkers and microbiological findings are important for follow-up and reevaluation of the suspected diagnosis.
authors.affiliation: Zentrum Anästhesiologie, Rettungs- und Intensivmedizin, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. tperl@medizin.uni-goettingen.de
authors.forename: T
authors.initials: T
authors.lastname: Perl
authors.forename: M
authors.initials: M
authors.lastname: Quintel
mesh_terms: D000891:Anti-Infective Agents, Local; D015415:Biomarkers; D003422:Critical Care; D017052:Hospital Mortality; D006801:Humans; D007442:Intubation, Intratracheal; D007902:Length of Stay; D053717:Pneumonia, Ventilator-Associated / Q000175:diagnosis* / Q000382:microbiology / Q000503:physiopathology / Q000517:prevention & control*; D012121:Respiration, Artificial
chemical_list: D000891:Anti-Infective Agents, Local; D015415:Biomarkers