title: Imaging of lung cancer in the era of molecular medicine.
abstract: Recent discoveries characterizing the molecular basis of lung cancer brought fundamental changes in lung cancer treatment. The authors review the molecular pathogenesis of lung cancer, including genomic abnormalities, targeted therapies, and resistance mechanisms, and discuss lung cancer imaging with novel techniques. Knowledge of the molecular basis of lung cancer is essential for radiologists to properly interpret imaging and assess response to therapy. Quantitative and functional imaging helps assessing the biologic behavior of lung cancer.
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02115, USA. mizuki_nishino@dfci.harvard.edu
authors.forename: Mizuki
authors.initials: M
authors.lastname: Nishino
authors.forename: David M
authors.initials: DM
authors.lastname: Jackman
authors.forename: Hiroto
authors.initials: H
authors.lastname: Hatabu
authors.forename: Pasi A
authors.initials: PA
authors.lastname: Jänne
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Johnson
authors.forename: Annick D
authors.initials: AD
authors.lastname: Van den Abbeele
mesh_terms: D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis*; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends*