title: Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children.
abstract: Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carried mupA, and the gene was more common in methicillin-susceptible S. aureus (21.4%) than methicillin-resistant S. aureus (8.3%; P=0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Feigin Center, Suite 1150, 1102 Bates St., Houston, TX 77030, USA.
authors.forename: J Chase
authors.initials: JC
authors.lastname: McNeil
authors.forename: Kristina G
authors.initials: KG
authors.lastname: Hulten
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Kaplan
authors.forename: Edward O
authors.initials: EO
authors.lastname: Mason
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D002981:Clindamycin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D016712:Mupirocin / Q000494:pharmacology* / Q000627:therapeutic use*; D018461:Soft Tissue Infections / Q000188:drug therapy / Q000382:microbiology; D013207:Staphylococcal Skin Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin; D016712:Mupirocin