title: [Bladder malformations in a model of myelomeningocele. Preliminary report].
abstract: OBJECTIVE
  To describe the presence of bladder malformations in a surgically induced model of myelomeningocele (MMC).
  
  
  METHODS
  A MMC like defect was created in the mid gestation using the previously described model in sheep. Bladders were examined macroscopically and histopathological changes were assessed using H-E.
  
  
  RESULTS
  Non prenatally corrected animals presented dilated bladders and separation between muscle bundles. Those malformations were not found in corrected animals or controls.
  
  
  CONCLUSIONS
  Some bladder changes can be described in a surgically-induced model of MMC. These changes could be prevented using open fetal surgery.
authors.affiliation: Departamento de Cirugía Pediátrica, Hospital La Paz, Madrid.
authors.forename: J L
authors.initials: JL
authors.lastname: Encinas
authors.forename: M
authors.initials: M
authors.lastname: Germani
authors.forename: L
authors.initials: L
authors.lastname: Burgos
authors.forename: C
authors.initials: C
authors.lastname: Soto
authors.forename: F
authors.initials: F
authors.lastname: Pederiva
authors.forename: A
authors.initials: A
authors.lastname: Luis
authors.forename: L F
authors.initials: LF
authors.lastname: Avila
authors.forename: M A
authors.initials: MA
authors.lastname: García-Cabezas
authors.forename: J L
authors.initials: JL
authors.lastname: Peiró
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: López-Santamaría
authors.forename: J A
authors.initials: JA
authors.lastname: Tovar
mesh_terms: D000818:Animals; D000013:Congenital Abnormalities / Q000517:prevention & control; D004195:Disease Models, Animal; D046128:Fetal Therapies; D008591:Meningomyelocele / Q000150:complications / Q000601:surgery; D012756:Sheep; D001743:Urinary Bladder / Q000002:abnormalities*