title: Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat self-poisoning.
abstract: An increase in creatinine > 3 μmol/L/h has been suggested to predict death in patients with paraquat self-poisoning and the value of other plasma biomarkers of acute kidney injury has not been assessed. The aim of this study was to validate the predictive value of serial creatinine concentrations and to study the utility of cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) as predictors of outcome in patients with acute paraquat poisoning. The rate of change of creatinine (dCr/dt) and cystatin C (dCyC/dt) concentrations were compared between survivors and deaths. Receiver-operating characteristic (ROC) curves were constructed to determine the best threshold for predicting death. Paraquat was detected in 20 patients and 7 of these died between 18 h and 20 days post-ingestion. The dCr/dt ROC curve had an area of 0.93 and the cut-off was > 4.3 μmol/L/h (sensitivity 100%, specificity 85%, likelihood ratio 7). The dCyC/dt ROC curve had an area of 0.97 and the cutoff was > 0.009 mg/L/h (sensitivity 100%, specificity 91%, likelihood ratio 11). NGAL did not separate survivors from deaths. Death due to acute paraquat poisoning is associated with changes in creatinine and cystatin concentrations. Further validation of these measurements is needed before they can be adopted in guiding intensive treatments.
authors.affiliation: South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka. 1darren1@gmail.com
authors.forename: Darren M
authors.initials: DM
authors.lastname: Roberts
authors.forename: Martin F
authors.initials: MF
authors.lastname: Wilks
authors.forename: Michael S
authors.initials: MS
authors.lastname: Roberts
authors.forename: Ramasamyiyer
authors.initials: R
authors.lastname: Swaminathan
authors.forename: Fahim
authors.initials: F
authors.lastname: Mohamed
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Dawson
authors.forename: Nick A
authors.initials: NA
authors.lastname: Buckley
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D000209:Acute-Phase Proteins / Q000592:standards; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood* / Q000592:standards; D055316:Cystatin C / Q000097:blood* / Q000592:standards; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood* / Q000592:standards; D010269:Paraquat / Q000506:poisoning*; D011041:Poisoning / Q000097:blood* / Q000175:diagnosis; D011518:Proto-Oncogene Proteins / Q000097:blood* / Q000592:standards; D013406:Suicide, Attempted
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D055316:Cystatin C; D006540:Herbicides; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine; D010269:Paraquat