title: Increase of plasminogen activator inhibitor-1 and decrease of transforming growth factor-b1 in children with dengue haemorrhagic fever in Indonesia.
abstract: Mortality in children with severe dengue haemorrhagic fever (DHF) in Indonesia is high. The origin of the elevated plasminogen activator inhibitor-1 (PAI-1) levels in these children is unclear. We measured PAI-1, transforming growth factor-β1 (TGF-β1), platelet counts, plasma leakage and liver function in 71 children with DHF (3-15 years old) and in 30 healthy children. We found that PAI-1 concentrations in children with DHF were significantly higher on admission than on Day 2. Circulating TGF-β1 concentrations on admission were significantly lower in DHF than in controls, but on Day 2 increased towards levels in controls. TGF-β1 and PAI-1 concentrations were not correlated on either day. PAI-1 was correlated with platelet count and serum albumin on admission, and with degree of pleural effusion. Liver function tests were mildly elevated but not correlated with PAI-1. In conclusion, elevated PAI-1 concentrations in DHF were associated with platelet counts and plasma leakage.
authors.affiliation: Faculty of Medicine, Department of Parasitology, Dr Kariadi Hospital and Faculty of Medicine, Diponegoro University, Semarang, Indonesia. ramus64@yahoo.com
authors.forename: Kis
authors.initials: K
authors.lastname: Djamiatun
authors.forename: Sultana M H
authors.initials: SM
authors.lastname: Faradz
authors.forename: Tatty E
authors.initials: TE
authors.lastname: Setiati
authors.forename: Mihai G
authors.initials: MG
authors.lastname: Netea
authors.forename: Andre J A M
authors.initials: AJ
authors.lastname: van der Ven
authors.forename: Wil M V
authors.initials: WM
authors.lastname: Dolmans
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007214:Indonesia; D008111:Liver Function Tests; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D010976:Platelet Count; D010996:Pleural Effusion; D012709:Serum Albumin / Q000378:metabolism; D019595:Severe Dengue / Q000097:blood* / Q000503:physiopathology; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D012709:Serum Albumin; D053773:Transforming Growth Factor beta1