title: A functional magnetic resonance imaging investigation of episodic memory after traumatic brain injury.
abstract: Traumatic brain injury often negatively impacts episodic memory; however, studies of the neural substrates of this impairment have been limited. In this study, both encoding and recognition of visually presented stimuli were examined with functional magnetic resonance imaging. Twelve adults with chronic complicated mild, moderate, and severe injuries were compared with a matched group of 12 controls. Behavioral task performance did not differentiate the groups. During neuroimaging, however, the group of individuals with traumatic brain injury exhibited increased activation, as well as increased bilaterality and dispersion as compared to controls. Findings are discussed in terms of increased resource recruitment.
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Russell
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Arenth
authors.forename: Joelle M
authors.initials: JM
authors.lastname: Scanlon
authors.forename: Lauren J
authors.initials: LJ
authors.lastname: Kessler
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Ricker
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000150:complications*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation; D011930:Reaction Time; D055815:Young Adult
chemical_list: D010100:Oxygen