title: Carotid stenosis as predictor of stroke after transient ischemic attacks.
abstract: ABCD2 score identifies high-risk TIAs but its validity in different countries and hospitals is unknown. Doubts remain also about the role of diagnostic work up for patients with TIAs in the emergency department. The present study was undertaken to confirm the usefulness of ABCD2 score in the emergency department of Trento Hospital and to evaluate if other exams (carotid ultrasound or CT scan) commonly performed in TIA patients are helpful. We retrospectively analysed discharge diagnosis of around 120,000 patients seen at the first aid of Trento Hospital over a 28 month period. ABCD2 score, carotid ultrasound and CT scan were recorded and were correlated with recurrence of stroke at different time points (mean follow-up period of 11.4 months) in all patients with TIA. We identified 965 patients with focal neurologic deficit and 502 could be classified as TIA. An ischemic stroke recurred in 30 patients at the end of the follow-up (30% in the first two days). ABCD2 score confirmed its value. A significant carotid stenosis (>70%) was an independent risk factor for stroke at any time point. Our study confirms the role of ABCD2 in a large Italian cohort of TIA patients but also suggests the importance of performing a carotid ultrasound as soon as possible.
authors.affiliation: Stroke Unit, Department of Neurological Disorders, Santa Chiara Hospital, Trento, Italy. dmbonifati@alice.it
authors.forename: Domenico Marco
authors.initials: DM
authors.lastname: Bonifati
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lorenzi
authors.forename: Mario
authors.initials: M
authors.lastname: Ermani
authors.forename: Franca
authors.initials: F
authors.lastname: Refatti
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Gremes
authors.forename: Claudio
authors.initials: C
authors.lastname: Boninsegna
authors.forename: Stefania
authors.initials: S
authors.lastname: Filipponi
authors.forename: Daniele
authors.initials: D
authors.lastname: Orrico
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology; D016893:Carotid Stenosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D048909:Diabetes Complications / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013064:Speech Disorders / Q000209:etiology; D020521:Stroke / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D055815:Young Adult