title: DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium.
abstract: In order to elucidate the transcriptional response of kidney epithelial cells to cadmium, the gene expression pattern was examined in normal rat kidney epithelial cells (NRK-52E cells) exposed to 50 µM cadmium for 4 hr using DNA microarray. Cadmium was found to increase the expression of 73 genes and decrease the expression of 42 genes in NRK-52E cells before the development of cytotoxicity.
authors.affiliation: Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, Gifu, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Tokumoto
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ohtsu
authors.forename: Akiko
authors.initials: A
authors.lastname: Honda
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Nagase
authors.forename: Masahiko
authors.initials: M
authors.lastname: Satoh
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D002478:Cells, Cultured; D015536:Down-Regulation; D004785:Environmental Pollutants / Q000633:toxicity*; D004847:Epithelial Cells / Q000187:drug effects*; D015870:Gene Expression / Q000187:drug effects*; D007668:Kidney / Q000166:cytology* / Q000187:drug effects*; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D015854:Up-Regulation
chemical_list: D004785:Environmental Pollutants; D002104:Cadmium