title: Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians.
abstract: We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93-1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93-1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.
authors.affiliation: Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan.
authors.forename: Aritoshi
authors.initials: A
authors.lastname: Iida
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Min
authors.initials: M
authors.lastname: Deng
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Naoki
authors.initials: N
authors.lastname: Atsuta
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tanaka
authors.forename: Tetsumasa
authors.initials: T
authors.lastname: Kamei
authors.forename: Motoki
authors.initials: M
authors.lastname: Sano
authors.forename: Shuichi
authors.initials: S
authors.lastname: Oshima
authors.forename: Torao
authors.initials: T
authors.lastname: Tokuda
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Morita
authors.forename: Chizuru
authors.initials: C
authors.lastname: Akimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakajima
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Imaharu
authors.initials: I
authors.lastname: Nakano
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Fan
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D000483:Alleles; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D002888:Chromosomes, Human, Pair 19; D002899:Chromosomes, Human, Pair 9; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide