title: Adverse reaction to metal debris following hip resurfacing: the influence of component type, orientation and volumetric wear.
abstract: We sought to establish the incidence of joint failure secondary to adverse reaction to metal debris (ARMD) following metal-on-metal hip resurfacing in a large, three surgeon, multicentre study involving 4226 hips with a follow-up of 10 to 142 months. Three implants were studied: the Articular Surface Replacement; the Birmingham Hip Resurfacing; and the Conserve Plus. Retrieved implants underwent analysis using a co-ordinate measuring machine to determine volumetric wear. There were 58 failures associated with ARMD. The median chromium and cobalt concentrations in the failed group were significantly higher than in the control group (p < 0.001). Survival analysis showed a failure rate in the patients with Articular Surface Replacement of 12.8% [corrected] at five years, compared with < 1% at five years for the Conserve Plus and 1.5% at ten years for the Birmingham Hip Resurfacing. Two ARMD patients had relatively low wear of the retrieved components. Increased wear from the metal-on-metal bearing surface was associated with an increased rate of failure secondary to ARMD. However, the extent of tissue destruction at revision surgery did not appear to be dose-related to the volumetric wear.
authors.affiliation: Northern Deanery, Goldcrest Way, Newcastle-upon-Tyne, NE15 8NY, UK. djlangton22@doctors.org.uk
authors.forename: D J
authors.initials: DJ
authors.lastname: Langton
authors.forename: T J
authors.initials: TJ
authors.lastname: Joyce
authors.forename: S S
authors.initials: SS
authors.lastname: Jameson
authors.forename: J
authors.initials: J
authors.lastname: Lord
authors.forename: M
authors.initials: M
authors.lastname: Van Orsouw
authors.forename: J P
authors.initials: JP
authors.lastname: Holland
authors.forename: A V F
authors.initials: AV
authors.lastname: Nargol
authors.forename: K A
authors.initials: KA
authors.lastname: De Smet
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000379:methods; D002857:Chromium / Q000097:blood; D003035:Cobalt / Q000097:blood; D019544:Equipment Failure Analysis / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D016019:Survival Analysis
chemical_list: D002857:Chromium; D003035:Cobalt