title: Photosensitizer-doped conjugated polymer nanoparticles with high cross-sections for one- and two-photon excitation.
abstract: We report a novel nanoparticle that is promising for photodynamic therapy applications, which consists of a π-conjugated polymer doped with a singlet oxygen photosensitizer. The nanoparticles exhibit highly efficient collection of excitation light due to the large excitation cross-section of the polymer. A quantum efficiency of singlet oxygen production of 0.5 was determined. Extraordinarily large two-photon excitation cross-sections were determined, indicating promise for near infrared multiphoton photodynamic therapy. Gel electrophoresis of DNA after near-UV irradiation in the presence of nanoparticles indicated both purine base and backbone DNA damage.
authors.affiliation: Department of Chemistry, Clemson University, Clemson, South Carolina 29634, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Grimland
authors.forename: Changfeng
authors.initials: C
authors.lastname: Wu
authors.forename: Ria R
authors.initials: RR
authors.lastname: Ramoutar
authors.forename: Julia L
authors.initials: JL
authors.lastname: Brumaghim
authors.forename: Jason
authors.initials: J
authors.lastname: McNeill
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004249:DNA Damage; D008027:Light; D008422:Materials Testing; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D017785:Photons; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry
chemical_list: D017319:Photosensitizing Agents; D011108:Polymers; D004247:DNA