title: Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists.
abstract: The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β(1)/β(2)-adrenergic activities and the corresponding structure-activity relationship (SAR). We have focused on lipophilicity and duration of action, and we have discovered a strong correlation in this series of molecules. A quantitative structure-activity relationship (QSAR) analysis will be presented that quantifies this relationship.
authors.affiliation: Department of Medicinal Chemistry, Almirall, Barcelona, Spain. daniel.perez@almirall.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Pérez
authors.forename: Maribel
authors.initials: M
authors.lastname: Crespo
authors.forename: Laia
authors.initials: L
authors.lastname: Solé
authors.forename: Maria
authors.initials: M
authors.lastname: Prat
authors.forename: Carla
authors.initials: C
authors.lastname: Carcasona
authors.forename: Elena
authors.initials: E
authors.lastname: Calama
authors.forename: Raquel
authors.initials: R
authors.lastname: Otal
authors.forename: Amadeu
authors.initials: A
authors.lastname: Gavaldá
authors.forename: Mireia
authors.initials: M
authors.lastname: Gómez-Angelats
authors.forename: Montserrat
authors.initials: M
authors.lastname: Miralpeix
authors.forename: Carles
authors.initials: C
authors.lastname: Puig
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists; D055808:Drug Discovery; D015394:Molecular Structure; D019800:Phenol / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship; D014508:Urea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D019800:Phenol; D014508:Urea