title: Maternal immunization with tetanus-diphtheria-pertussis vaccine: effect on maternal and neonatal serum antibody levels.
abstract: OBJECTIVE
  We sought to determine whether tetanus-diphtheria-pertussis vaccination (Tdap) in pregnancy provides newborns antibodies against pertussis when compared to mothers who did not receive Tdap.
  
  
  METHODS
  Paired maternal and umbilical cord blood samples were collected at the time of delivery and the serum stored at -86°C. For each paired sample of maternal and cord blood, the medical chart and vaccine history was reviewed to determine whether Tdap was received or not.
  
  
  RESULTS
  Newborns born from mothers who received Tdap during pregnancy had significantly higher concentrations of diphtheria antitoxin (P < .001), tetanus antitoxin (P = .004), and antibodies to pertussis toxin (P < .001), filamentous hemagglutinin (P = .002), pertactin (P < .001), and fimbriae 2/3 (P < .001) when compared to newborns from mothers who did not receive Tdap. There was a significant increase in the odds that newborns from mothers who received Tdap during pregnancy have antibodies that may provide protection against diphtheria (P = .0141), pertussis toxin (P < .0001), and fimbriae 2/3 (P = .0146).
  
  
  CONCLUSIONS
  Administering Tdap during pregnancy increases antibody titers against diphtheria and pertussis antigens. Maternal Tdap may prevent neonatal pertussis infection.
authors.affiliation: Department of Obstetrics, Gynecology, and Women's Health, School of Medicine, University of Louisville, Louisville, KY, USA.
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Gall
authors.forename: John
authors.initials: J
authors.lastname: Myers
authors.forename: Michael
authors.initials: M
authors.lastname: Pichichero
mesh_terms: D018829:Adhesins, Bacterial / Q000276:immunology; D000906:Antibodies / Q000097:blood*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D004166:Diphtheria Antitoxin / Q000097:blood; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D005260:Female; D036781:Fimbriae Proteins / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D037342:Pertussis Toxin / Q000276:immunology; D011247:Pregnancy; D013743:Tetanus Antitoxin / Q000097:blood; D010566:Virulence Factors, Bordetella / Q000276:immunology
chemical_list: D018829:Adhesins, Bacterial; D000906:Antibodies; D001425:Bacterial Outer Membrane Proteins; D004166:Diphtheria Antitoxin; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D013743:Tetanus Antitoxin; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis; D036781:Fimbriae Proteins; C068929:pertactin; D037342:Pertussis Toxin