title: 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients.
abstract: BACKGROUND
  Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla.
  
  
  METHODS
  Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls.
  
  
  RESULTS
  A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls.
  
  
  CONCLUSIONS
  The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.
authors.affiliation: MR Department, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium. harmen.reyngoudt@ugent.be
authors.forename: Harmen
authors.initials: H
authors.lastname: Reyngoudt
authors.forename: Koen
authors.initials: K
authors.lastname: Paemeleire
authors.forename: Benedicte
authors.initials: B
authors.lastname: Descamps
authors.forename: Yves
authors.initials: Y
authors.lastname: De Deene
authors.forename: Eric
authors.initials: E
authors.lastname: Achten
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D000328:Adult; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D020326:Migraine without Aura / Q000378:metabolism*; D009778:Occipital Lobe / Q000378:metabolism*; D010710:Phosphates / Q000032:analysis / Q000378:metabolism; D010725:Phosphocreatine / Q000032:analysis / Q000378:metabolism
chemical_list: D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate