title: Gait alterations in healthy carriers of the LRRK2 G2019S mutation.
abstract: To test for an association between the LRRK2-G2019S mutation and gait, we studied 52 first-degree relatives of patients with Parkinson's disease (PD) who carry this mutation. An accelerometer quantified gait during usual-walking, fast-walking, and dual-tasking. Noncarriers (n = 27) and carriers (n = 25) were similar with respect to age, gender, height, and gait speed during all conditions. During dual-tasking and fast-walking, gait variability and the amplitude of the dominant peak of the accelerometer signal were significantly altered among the carriers. These findings support the possibility of previously unidentified, presymptomatic motor changes among relatives who have an increased risk of developing PD.
authors.affiliation: Movement Disorders Unit, Department of NeurologyTel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. anatmi@tasmc.health.gov.il
authors.forename: Anat
authors.initials: A
authors.lastname: Mirelman
authors.forename: Tanya
authors.initials: T
authors.lastname: Gurevich
authors.forename: Nir
authors.initials: N
authors.lastname: Giladi
authors.forename: Anat
authors.initials: A
authors.lastname: Bar-Shira
authors.forename: Avi
authors.initials: A
authors.lastname: Orr-Urtreger
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Hausdorff
mesh_terms: D020234:Gait Ataxia / Q000235:genetics* / Q000503:physiopathology; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases