title: Encaging the Verkade's superbases: thermodynamic and kinetic consequences.
abstract: Proazaphosphatranes, also known as Verkade's superbases, are nonionic species, which exhibit catalytic properties for a wide range of reactions. The properly designed host molecule 3 and its protonated counterpart [3·H](+)Cl(-) were synthesized to study how confinement can modify the stability and the reactivity of a Verkade's superbase. The results show that the encapsulation does not alter the strong basicity of the proazaphosphatrane, but dramatically decreases the rate of proton transfer.
authors.affiliation: Laboratoire de Chimie, École Normale Supérieure de Lyon, CNRS, 46 Allée d'Italie, F-69364 Lyon, France.
authors.forename: Pascal Dimitrov
authors.initials: PD
authors.lastname: Raytchev
authors.forename: Alexandre
authors.initials: A
authors.lastname: Martinez
authors.forename: Heinz
authors.initials: H
authors.lastname: Gornitzka
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Dutasta
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D007700:Kinetics; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011522:Protons; D013816:Thermodynamics
chemical_list: D009943:Organophosphorus Compounds; D011522:Protons; C449943:P(CH(3)NCH(2)CH(2))(3)N