title: Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix.
abstract: OBJECTIVE
  Recalcitrant diabetic wounds are not responsive to the most common treatments. Bone marrow-derived stem cell transplantation is used for the healing of chronic lower extremity wounds.
  
  
  METHODS
  We report on the treatment of eight patients with aggressive, refractory diabetic wounds. The marrow-derived cells were injected/applied topically into the wound along with platelets, fibrin glue and bone marrow-impregnated collagen matrix.
  
  
  RESULTS
  Four weeks after treatment, the wound was completely closed in three patients and significantly reduced in the remaining five patients.
  
  
  CONCLUSIONS
  Our study suggests that the combination of the components mentioned can be used safely in order to synergize the effect of chronic wound healing.
authors.affiliation: Vascular and Endovascular Research Center, Imamreza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Ravari
authors.forename: Daryoush
authors.initials: D
authors.lastname: Hamidi-Almadari
authors.forename: Mohsen
authors.initials: M
authors.lastname: Salimifar
authors.forename: Shokofeh
authors.initials: S
authors.lastname: Bonakdaran
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Parizadeh
authors.forename: George
authors.initials: G
authors.lastname: Koliakos
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000502:physiology*; D001854:Bone Marrow Cells / Q000166:cytology*; D016026:Bone Marrow Transplantation; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D015718:Fibrin Tissue Adhesive; D003094:Collagen