title: New pathway links γ-secretase to inflammation and memory while sparing notch.
authors.forename: Sam
authors.initials: S
authors.lastname: Gandy
authors.forename: Brandon
authors.initials: B
authors.lastname: Wustman
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001381:Azepines / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D050882:CREB-Binding Protein / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D008568:Memory / Q000502:physiology*; D051379:Mice; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D001381:Azepines; D008565:Membrane Proteins; C484278:N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide; D051880:Receptors, Notch; D050882:CREB-Binding Protein; C494364:Crebbp protein, mouse; D053829:Amyloid Precursor Protein Secretases; D000409:Alanine