title: Galanin systems in non-mammalian vertebrates with special focus on fishes.
abstract: Galanin is a well characterized multifunctional neuropeptide in mammals. Galanin has been identified from several fishes, amphibians, reptiles and birds. A large set of data is available on galanin-like protein distribution and peptide and/or mRNA sequences in non-mammalian vertebrates. Galanin receptor sequences from fishes and birds are known, but its distribution and mechanisms of actions are poorly understood. While some biological actions of galanin are known in non-mammals, the functional role of galanin in lower vertebrates is limited. For example, galanin has been shown to regulate feeding, pituitary hormone secretion and gut motility in fishes. Several aspects of galanin biology remain unknown, yet, there is enough evidence to implicate galanin as an important physiological modulator in lower vertebrates. Majority of the research articles on galanin in non-mammals arise from studies that used fishes. The objective of this chapter is to provide a summarized discussion of current knowledge on galanin peptide and gene sequences and organization, distribution of galanin gene and protein, and physiological functions of galanin in non-mammalian vertebrates with a special focus on fishes.
authors.affiliation: Laboratory of Integrative Neuroendocrinology, Department of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
authors.forename: Elsie Tachie
authors.initials: ET
authors.lastname: Mensah
authors.forename: Helene
authors.initials: H
authors.lastname: Volkoff
authors.forename: Suraj
authors.initials: S
authors.lastname: Unniappan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005399:Fishes / Q000502:physiology*; D019004:Galanin / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014714:Vertebrates / Q000502:physiology*
chemical_list: D012333:RNA, Messenger; D019004:Galanin