title: Antifungal activity displayed by cereulide, the emetic toxin produced by Bacillus cereus.
abstract: In this study, the fungistatic activity of Bacillus cereus cereulide-producing strains was demonstrated against nine fungal species. The role of cereulide was confirmed using plasmid-cured derivatives and ces knockout mutants. The fungistatic spectra of cereulide and valinomycin, a chemically related cyclododecadepsipeptide, were also compared and found to be similar but distinct.
authors.affiliation: Laboratory of Food and Environmental Microbiology, Université Catholique de Louvain, Croix du Sud 2/12, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: Sandy
authors.initials: S
authors.lastname: Ladeuze
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lentz
authors.forename: Laurence
authors.initials: L
authors.lastname: Delbrassinne
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Hu
authors.forename: Jacques
authors.initials: J
authors.lastname: Mahillon
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001409:Bacillus cereus / Q000378:metabolism*; D047630:Depsipeptides / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D017353:Gene Deletion; D005798:Genes, Bacterial; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D014634:Valinomycin / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D047630:Depsipeptides; C089294:cereulide; D014634:Valinomycin