title: The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats.
abstract: OBJECTIVE
  To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats.
  
  
  METHODS
  Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2(nd), 4(th), 5(th), 7(th), 10(th) and 15(th) week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis.
  
  
  RESULTS
  The intratesticular testosterone level was significantly (P<0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P<0.001) increased by valproate in a time dependent manner.
  
  
  CONCLUSIONS
  Valproate causes reversible change in intratesticular testosterone and LDH level.
authors.affiliation: Department of Anatomy, Maleka Manipal Medical College, Manipal, India.
authors.forename: P
authors.initials: P
authors.lastname: Vijay
authors.forename: R
authors.initials: R
authors.lastname: Yeshwanth
authors.forename: K L
authors.initials: KL
authors.lastname: Bairy