title: Autonomic MC sets the metabolic tone.
abstract: The CNS melanocortin (MC) and the autonomic nervous (ANS) system represent key regulators of energy homeostasis. In this issue, Rossi et al. (2011) dissect metabolic functions of MC4 receptors based on anatomic localization within the ANS by re-expressing MC4R subpopulations in cholinergic or brainstem neurons of MC4R-KO mice.
authors.affiliation: Metabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati, Cincinnati, OH 45226, USA.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Yi
authors.forename: Andries
authors.initials: A
authors.lastname: Kalsbeek
authors.forename: Matthias H
authors.initials: MH
authors.lastname: Tschöp