title: Pervasive regulation of nucleoid structure and function by nucleoid-associated proteins.
abstract: Bacterial DNA is organised in a compact nucleoid body that is tightly associated with the coupled transcription and translation of mRNAs. This structure contains abundant DNA-binding proteins which perform both structural and regulatory roles, and, in Escherichia coli, serve to buffer and organise pervasive DNA superhelicity. We argue that NAPs coordinate regulation of gene expression and superhelicity at the global (or chromosomal) and at local (corresponding to promoter activity and genetic recombination) levels.
authors.affiliation: LBPA, Ecole Normale Supérieure de Cachan, CNRS, 94235 Cachan, France. rimsky@lbpa.ens-cachan.fr
authors.forename: Sylvie
authors.initials: S
authors.lastname: Rimsky
authors.forename: Andrew
authors.initials: A
authors.lastname: Travers
mesh_terms: D002876:Chromosomes, Bacterial / Q000378:metabolism* / Q000648:ultrastructure*; D004269:DNA, Bacterial / Q000378:metabolism* / Q000648:ultrastructure*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D014176:Protein Biosynthesis; D014158:Transcription, Genetic
chemical_list: D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins