title: 3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.
abstract: 3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data.
authors.affiliation: Cancer Research, AstraZeneca R&D Boston, Waltham, MA 02451, USA. david.scott@astrazeneca.com
authors.forename: David A
authors.initials: DA
authors.lastname: Scott
authors.forename: Les A
authors.initials: LA
authors.lastname: Dakin
authors.forename: David J
authors.initials: DJ
authors.lastname: Del Valle
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Diebold
authors.forename: Lisa
authors.initials: L
authors.lastname: Drew
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Gero
authors.forename: Claude A
authors.initials: CA
authors.lastname: Ogoe
authors.forename: Charles A
authors.initials: CA
authors.lastname: Omer
authors.forename: Galina
authors.initials: G
authors.lastname: Repik
authors.forename: Kumar
authors.initials: K
authors.lastname: Thakur
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D004285:Dogs; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000814:Aniline Compounds; D006574:Heterocyclic Compounds, 2-Ring; D047428:Protein Kinase Inhibitors; D016186:Receptor, Macrophage Colony-Stimulating Factor; C476282:cinnoline; C023650:aniline