title: Does finasteride have a preventive effect on chronic bacterial prostatitis? Pilot study using an animal model.
abstract: OBJECTIVE
  To evaluate the preventive effect of finasteride on chronic bacterial prostatitis (CBP), Wistar rats were divided into four groups: control, ciprofloxacin, finasteride, and ciprofloxacin/finasteride.
  
  
  METHODS
  All drug pretreatments were conducted for 4 weeks, and then experimental CBP was induced by instillation of a bacterial suspension (Escherichia coli Z17 O2:K1;H-).
  
  
  RESULTS
  After 4 weeks, results of microbiological cultures of prostate and urine samples as well as histological findings of the prostate in each group were analyzed. Finasteride significantly reduced bacterial infection and decreased inflammatory cell infiltration in prostatic tissue compared with the control group. The group given both finasteride and antibiotic showed a greater inhibition of bacterial infection in the tissue than those given either finasteride or antibiotic alone.
  
  
  CONCLUSIONS
  Our experiments suggest the possibility that finasteride has a preventive effect on development of CBP, although there is as yet no consensus on the mechanism of this effect.
authors.affiliation: The Catholic University of Korea College of Medicine, Department of Urology, St Vincent Hospital, Suwon, Korea.
authors.forename: Choong Bum
authors.initials: CB
authors.lastname: Lee
authors.forename: U-Syn
authors.initials: US
authors.lastname: Ha
authors.forename: Seung Hyuk
authors.initials: SH
authors.lastname: Yim
authors.forename: Hyun Rim
authors.initials: HR
authors.lastname: Lee
authors.forename: Dong Wan
authors.initials: DW
authors.lastname: Sohn
authors.forename: Chang Hee
authors.initials: CH
authors.lastname: Han
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Cho
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000378:metabolism; D004927:Escherichia coli Infections / Q000188:drug therapy*; D018120:Finasteride / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011472:Prostatitis / Q000188:drug therapy* / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D018120:Finasteride