title: Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them.
abstract: Seven sesquiterpenoids, hiiranlactones A-D (1-4), (-)-ent-6α-methoxyeudesm-4(15)-en-1β-ol (5), (+)-villosine (6), hiiranepoxide (7), and one triterpenoid, hiiranterpenone (8), together with 22 known compounds, were isolated from the leaves of Neolitsea hiiranensis (Lauraceae). Their structures were elucidated by spectroscopic analysis and single crystal X-ray diffraction. Among the isolates, hiiranlactone B (2) and hiiranlactone D (4) exhibited inhibitory activity against fMLP-induced superoxide production by human neutrophils with IC(50) values of 21.86±3.97 and 25.78±4.77μM, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
authors.forename: Bi-Jiuan
authors.initials: BJ
authors.lastname: Liou
authors.forename: Hsun-Shuo
authors.initials: HS
authors.lastname: Chang
authors.forename: Guei-Jane
authors.initials: GJ
authors.lastname: Wang
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Chang-Hui
authors.initials: CH
authors.lastname: Liao
authors.forename: Chu-Hung
authors.initials: CH
authors.lastname: Lin
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013624:Taiwan; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012717:Sesquiterpenes; D014315:Triterpenes; C558276:hiiranlactone B; C558275:hiiranlactone D; C558274:hiiranterpenone; D009240:N-Formylmethionine Leucyl-Phenylalanine