title: Effects of cyclic AMP on development and secondary metabolites of Monascus ruber M-7.
abstract: OBJECTIVE
  To study effects of cyclic adenosine monophosphate (cAMP) on development and secondary metabolites of Monascus ruber M-7.
  
  
  RESULTS
  Plate culture, liquid-state fermentation (LSF) and solid-state fermentation (SSF) were used to evaluate effects of cAMP on colonial growth, spore formation and polyketide production of Strain M-7. The results revealed that the variation trends of colonial sizes, numbers of sexual spores and red pigment contents of M-7 were in a dose-dependent manner. And generally they increased and decreased with cAMP concentrations in the ranges of low cAMP concentrations and high cAMP concentrations, respectively. But the variation trends of numbers of asexual spores and citrinin production in both LSF and SSF were opposite to those of colonial sizes, sexual sporulation and red pigment.
  
  
  CONCLUSIONS
  The regulation of cAMP on development and secondary metabolites in Strain M-7 was in a dose-dependent pattern. And red pigment might convert to citrinin under changing cAMP concentrations.
  
  
  CONCLUSIONS
  The effects of cAMP on Strain M-7 in SSF give a new clue to enhance beneficial polyketides and reduce citrinin produced by M. ruber.
authors.affiliation: College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Lai
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Qing
authors.forename: F
authors.initials: F
authors.lastname: Chen
mesh_terms: D002953:Citrinin / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology*; D005285:Fermentation; D032741:Monascus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
chemical_list: D002953:Citrinin; D000242:Cyclic AMP