title: [An analysis of RHD zygosity of Rh(D)-positive Chinese Han population].
abstract: OBJECTIVE
  To investigate the RHD zygosity of Rh(D)-positive Chinese Hans in order to study the mother-fetus Rh isoimmunization prophylaxis.
  
  
  METHODS
  Rh(D) blood group of 31 115 donors were serotyped, and the RHD zygosities were analyzed, or determined through a PCR method for 3628 donors of Rh(D)-positive individuals.
  
  
  RESULTS
  Among the 31 115 donors, 99 were tested Rh(D)-negative by indirect antiglobulin test (IAT) (0.318%). The d frequency was 0.056 41, D was 0.943 59, and Dd heterozygosity was 0.106 45 (10.6%). However the rate was 0.090 32 (about 9.0%) after excluding DEL (IAT-negative). For the 3628 PCR tested donors, 3383 were DD (93.2%), 245 were Dd (6.8%). After excluding nonfunctional RHD alleles, 7.4% of the donors were carrying one functional RHD. It showed that an Rh(D)-negative Chinese Han woman gives an Rh(D)-negative child at a rate of 3.7%-4.5% when her husband is Rh(D)-positive.
  
  
  CONCLUSIONS
  Fetus Rh(D) genotyping may be unnecessary for Chinese Hans if invasive operation was needed for prenatal diagnosis. The Rh prophylaxis could be chosen assuming an Rh(D)-positive fetus.
authors.affiliation: Shenzhen Blood Center, Shenzhen, Guangdong, 518035 PR China. cpshaos@hotmail.com
authors.forename: Chao-peng
authors.initials: CP
authors.lastname: Shao
authors.forename: Jian-jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Guo-dong
authors.initials: GD
authors.lastname: Sun
authors.forename: Hong-xian
authors.initials: HX
authors.lastname: Xu
authors.forename: Lin-feng
authors.initials: LF
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012204:Rh-Hr Blood-Group System / Q000097:blood / Q000235:genetics*
chemical_list: D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen