title: [The expression of periphery blood leucocyte CCR3 and CCR5 in the children with Epstein-Barr virus associated infectious mononucleosis].
abstract: OBJECTIVE
  To explore the expression of periphery blood leucocyte CCR3 and CCR5 and to comprehend T helper cell in the Children with Epstein-Barr virus associated infectious mononucleosis.
  
  
  METHODS
  We defined the children according to the diagnosis criterion through Paul-Bunnell test inspecting the children's periphery blood unusual lymphocyte and detecting their anti-EBV-CA-IgM, anti-EBV-CA-IgG and anti-EBV-NA-IgG by ELISA and counted the ratio of CCR3 + and CCR5 + cells in lymphocytes with flow cytometry.
  
  
  RESULTS
  The ratio of unusual lymphocyte in IM was higher than that of the healthy control group (P < 0.05). The ratio of CCR3 + cells in IM group was higher than that of the healthy control group (P < 0.05). The ratio of CCR5 + cells in IM group was significantly lower than that of the healthy control group. CCR3 + had direct interrelation with fever continued time and the ratio of unusual lymphocyte. There was a negative interrelation between CCR5 and fever continued time (P < 0.05).
  
  
  CONCLUSIONS
  Children infectious of IM expressed higher level of CCR3 + and lower level of CCR5 + and there was a tendency of Th2 polarization with over production of T helper cell divide imbalance. CCR3 + and CCR5 + may be important targets to judge the degree of seriousness of IM.
authors.affiliation: Department of Paediatrics of the Central Hospital of Aviation Industry Coporaition, Beijing 100012, China. qitiexiong2009@163.com
authors.forename: Tie-xiong
authors.initials: TX
authors.lastname: Qi
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Gao
authors.forename: Shi-hua
authors.initials: SH
authors.lastname: Liu
mesh_terms: D002648:Child; D002675:Child, Preschool; D015870:Gene Expression; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007244:Infectious Mononucleosis / Q000235:genetics / Q000276:immunology* / Q000821:virology; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D054397:Receptors, CCR3 / Q000235:genetics* / Q000276:immunology; D019713:Receptors, CCR5 / Q000235:genetics* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: C515350:CCR3 protein, human; D054397:Receptors, CCR3; D019713:Receptors, CCR5