title: Effect of protein malnutrition on the skin epidermis of hairless mice.
abstract: The purpose of this study was to evaluate the effect of protein malnutrition on the skin epidermis of mice. A low protein diet induced thinning of the skin epidermis, a decrease of cell proliferative activity in epidermal cells and a decrease of stratum corneum hydration. Dityrosine was immunostained in the cytoplasm of epidermal cells in the low protein diet group. Plasma advanced oxidation protein product (AOPP) levels were significantly more increased in the low protein diet group than in the control diet group. These results suggest that protein malnutrition adversely affects the structure and water barrier and reservoir functions of the skin epidermis, and these pathological changes are associated with the expressions of protein oxidation markers, dityrosine and AOPP.
authors.affiliation: Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori, Tottori 680–8553, Japan. sugiyama@muses.tottori-u.ac.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sugiyama
authors.forename: Yuka
authors.initials: Y
authors.lastname: Fujita
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Mizuyuki
authors.initials: M
authors.lastname: Ryu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Aino
authors.initials: A
authors.lastname: Masuda
authors.forename: Tairin
authors.initials: T
authors.lastname: Ochi
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D012709:Serum Albumin / Q000032:analysis; D014443:Tyrosine / Q000031:analogs & derivatives / Q000097:blood; D014870:Water Loss, Insensible / Q000502:physiology
chemical_list: D012709:Serum Albumin; D014443:Tyrosine; C007543:dityrosine