title: The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing.
abstract: Bisphosphonate effects on the skeleton have been studied in the context of a broad range of disciplines, including endocrinology, orthopedics, oncology, and dentistry. The emergence of osteonecrosis of the jaw as a rare but serious side effect of bisphosphonate treatment has stimulated interest in understanding how this drug class affects the oral skeleton. This review focuses on recent work describing how bisphosphonates affect bone remodeling, tissue properties, and postsurgical healing in the oral cavity.
authors.affiliation: Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS-5035, Indianapolis, IN, 46202, USA. matallen@iupui.edu.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Allen
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects*; D004164:Diphosphonates / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007568:Jaw / Q000187:drug effects; D007571:Jaw Diseases / Q000139:chemically induced; D010020:Osteonecrosis / Q000139:chemically induced; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*; D055114:X-Ray Microtomography
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates