title: Rapid, low-cost MR imaging protocol to document central nervous system and sinus abnormalities prior to pediatric hematopoietic stem cell transplantation.
abstract: Patients undergoing bone marrow transplant (BMT) are at risk for infectious complications, including those of the sinus. Central nervous system (CNS) abnormalities related to the chemotherapy or radiation that the patient received for the treatment of underlying malignancy or to transplant-related effects are also commonly seen. The only effective way to differentiate pre- and post-transplant causes is to have a baseline evaluation prior to the admission for transplant. The current method used to evaluate these patients is head CT. However, CT is not accurate to demonstrate CNS abnormalities and exposes the patient to radiation. MRI, despite better sensitivity for white matter abnormalities, has not been routinely used because of the higher cost and longer duration of the exam. Therefore, we designed a fast, low-cost and radiation-free MRI-based protocol to simultaneously evaluate sinus and brain abnormalities.
authors.affiliation: Department of Diagnostic Imaging, Universidade Federal de Sao Paulo, 800 Napoleao, São Paulo, Brazil. elianedonato@gmail.com
authors.forename: Eliane D
authors.initials: ED
authors.lastname: Leite
authors.forename: Adriana
authors.initials: A
authors.lastname: Seber
authors.forename: Felipe G
authors.initials: FG
authors.lastname: de Barbosa
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Ginani
authors.forename: Fabianne C
authors.initials: FC
authors.lastname: Carlesse
authors.forename: Roseane V
authors.initials: RV
authors.lastname: Gouvea
authors.forename: Victor G
authors.initials: VG
authors.lastname: Zecchin
authors.forename: Cinthya R
authors.initials: CR
authors.lastname: Carvalho
authors.forename: Gilberto
authors.initials: G
authors.lastname: Szarf
authors.forename: Henrique M
authors.initials: HM
authors.lastname: Lederman
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000191:economics / Q000209:etiology* / Q000473:pathology*; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D004282:Documentation / Q000191:economics; D005260:Female; D017048:Health Care Costs; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000191:economics*; D006412:Hematopoietic Stem Cells; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000191:economics* / Q000379:methods; D008297:Male; D010254:Paranasal Sinus Diseases / Q000191:economics / Q000209:etiology* / Q000473:pathology*; D011300:Preoperative Care / Q000191:economics; D016896:Treatment Outcome; D055815:Young Adult