title: Chemical and bioanalytical characterization of dioxins in indoor dust in Hong Kong.
abstract: In the present work, air-conditioner filter dust samples collected from commercial office, secondary school, shopping mall, electronic factory and manufacturing plant in Hong Kong were collected for 7-ethoxyresorufin O-deethylase (EROD) assay using a hepatoma cell line (H4IIE) and chemical analysis of dioxins including polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and PCBs with dioxin-like structure. The result of EROD assay showed that bioassay derived TEQ of 2,3,7,8-TCDD (TEQ(bio)) of dust samples varied from 320 to 730 pg/g. Chemical analyses revealed that chemical derived TEQ of 2,3,7,8-TCDD (TEQ(cal)) of dust samples ranged from 134 to 531 pg/g. In addition, the TEQ(cal) of samples were significantly correlated with TEQ(bio) of samples (R=0.83, P<0.01). The average daily doses (ADDs) of dioxins via indoor dust with the estimated ADDs of dioxins via air and food were compared. The results showed that indoor dust is an important medium of exposure to dioxins.
authors.affiliation: Croucher Institute for Environmental Sciences, and Department of Biology, Hong Kong Baptist University, Hong Kong, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Kang
authors.forename: Kwai Chung
authors.initials: KC
authors.lastname: Cheung
authors.forename: Zong Wei
authors.initials: ZW
authors.lastname: Cai
authors.forename: Ming H
authors.initials: MH
authors.lastname: Wong
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis* / Q000706:statistics & numerical data; D000818:Animals; D001572:Benzofurans / Q000032:analysis / Q000633:toxicity; D001681:Biological Assay; D045744:Cell Line, Tumor; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D004147:Dioxins / Q000032:analysis* / Q000633:toxicity; D004391:Dust / Q000032:analysis*; D004784:Environmental Monitoring; D006723:Hong Kong; D006801:Humans; D016273:Occupational Exposure / Q000032:analysis / Q000706:statistics & numerical data; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000032:analysis / Q000633:toxicity; D051381:Rats; D018570:Risk Assessment; D017132:Workplace / Q000706:statistics & numerical data
chemical_list: D000395:Air Pollutants, Occupational; D001572:Benzofurans; D004147:Dioxins; D004391:Dust; D000072317:Polychlorinated Dibenzodioxins; C023614:dibenzofuran; D011078:Polychlorinated Biphenyls; D019363:Cytochrome P-450 CYP1A1; C020887:dibenzo(1,4)dioxin