title: Synthesis and properties of MIDA boronate containing aromatic amino acids: new peptide building blocks.
abstract: Herein, we report the synthesis of novel phenylalanine and tyrosine derivatives containing a N-methyliminodiacetic acid boronate group. These compounds can be prepared enantiomerically pure, they are stable to column chromatography and they can be stored in air for two months without degradation occurring. This new class of boronate containing aromatic amino acids has potential applications in both peptide chemistry and natural product synthesis.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors.forename: Neil
authors.initials: N
authors.lastname: Colgin
authors.forename: Tony
authors.initials: T
authors.lastname: Flinn
authors.forename: Steven L
authors.initials: SL
authors.lastname: Cobb
mesh_terms: D024322:Amino Acids, Aromatic / Q000138:chemical synthesis*; D001896:Boron Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
chemical_list: D024322:Amino Acids, Aromatic; D001896:Boron Compounds; D010455:Peptides