title: Benzimidazole analogs inhibit human herpesvirus 6.
abstract: Several benzimidazole nucleoside analogs, including 1H-β-D-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-L-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of these compounds were evaluated against both variants of HHV-6, and two L-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more modest inhibition of HHV-6B replication.
authors.affiliation: University of Alabama School of Medicine, 1600 6th Avenue South, 128 Children's Harbor Building, Birmingham, AL 35233, USA. mprichard@peds.uab.edu
authors.forename: Mark N
authors.initials: MN
authors.lastname: Prichard
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Frederick
authors.forename: Shannon
authors.initials: S
authors.lastname: Daily
authors.forename: Katherine Z
authors.initials: KZ
authors.lastname: Borysko
authors.forename: Leroy B
authors.initials: LB
authors.lastname: Townsend
authors.forename: John C
authors.initials: JC
authors.lastname: Drach
authors.forename: Earl R
authors.initials: ER
authors.lastname: Kern
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects; D015654:Herpesvirus 6, Human / Q000187:drug effects*; D006801:Humans; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles