title: How to improve the immunogenicity of chemotherapy and radiotherapy.
abstract: Chemotherapy or radiotherapy could induce various tumor cell death modalities, releasing tumor-derived antigen as well as danger signals that could either be captured for triggering antitumor immune response or ignored. Exploring the interplay among therapeutic drugs, tumor cell death and the immune cells should improve diagnostic, prognostic, predictive, and therapeutic management of tumor. We summarized some of the cell death-derived danger signals and the mechanism for host to sense and response to cell death in the tumor microenvironment. Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity.
authors.affiliation: INSERM, U1015, 94805 Villejuif, France.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ma
authors.forename: Rosa
authors.initials: R
authors.lastname: Conforti
authors.forename: Laetitia
authors.initials: L
authors.lastname: Aymeric
authors.forename: Clara
authors.initials: C
authors.lastname: Locher
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007109:Immunity / Q000187:drug effects* / Q000528:radiation effects*; D016219:Immunotherapy, Adoptive; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000532:radiotherapy; D059016:Tumor Microenvironment / Q000187:drug effects / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines