title: Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex.
abstract: Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (sc) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
authors.affiliation: Drug Safety Japan, Global Drug Safety, Biopharmaceutical Assessments Core Function Unit, Eisai Product Creation Systems, Tsukuba, Ibaraki, Japan. m2-shiotani@hhc.eisai.co.jp
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shiotani
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakano
authors.forename: Emiko
authors.initials: E
authors.lastname: Yamauchi
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Oda
authors.forename: Satoru
authors.initials: S
authors.lastname: Hosokawa
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Aoki
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000187:drug effects*; D040901:Proteomics; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D014305:Triose-Phosphate Isomerase / Q000378:metabolism; D014617:Vacuoles / Q000187:drug effects*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D000251:Adenosine Triphosphatases; D005634:Fructose-Bisphosphate Aldolase; D014305:Triose-Phosphate Isomerase