title: Paper spray ionization of polar analytes using non-polar solvents.
abstract: Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper.
authors.affiliation: Department of Chemistry and Center for Analytical Instrumentation Development, 560 Oval Drive, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Anyin
authors.initials: A
authors.lastname: Li
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ouyang
authors.forename: R Graham
authors.initials: RG
authors.lastname: Cooks
mesh_terms: D006586:Hexanes / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods*; D010209:Paper; D012997:Solvents / Q000737:chemistry*
chemical_list: D006586:Hexanes; D012997:Solvents