title: Evaluation of the effect of two gadolinium-containing contrast-enhancing agents, gadobutrol and gadoxetate disodium, on colorimetric calcium determinations in serum and plasma.
abstract: OBJECTIVE
  To determine the extent to which the gadolinium-containing contrast agents, gadobutrol (Gadovist) and gadoxetate disodium (Primovist/Eovist), interfere with the colorimetric measurement of calcium concentrations in serum and plasma.
  
  
  METHODS
  Gadobutrol and gadoxetate disodium were added in various concentrations to serum and plasma from healthy volunteers; the calcium concentration in these samples was then measured by standard colorimetry methods and atomic absorption.
  
  
  RESULTS
  At clinically relevant concentrations, neither gadobutrol nor gadoxetate disodium influenced the results of the calcium measurement in serum or plasma. Only at the highest concentrations tested (50 mM gadobutrol; 25 mM gadoxetate disodium), an effect was seen in some cases. Results were confirmed by atomic absorption spectroscopy as the reference method.
  
  
  CONCLUSIONS
  At clinically relevant concentrations, gadobutrol and gadoxetate disodium did not interfere with standard colorimetric methods for calcium determination.
authors.affiliation: Bayer HealthCare, Berlin, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Löwe
authors.forename: Josy
authors.initials: J
authors.lastname: Breuer
authors.forename: Petra
authors.initials: P
authors.lastname: Palkowitsch
mesh_terms: D001774:Blood Chemical Analysis; D002118:Calcium / Q000097:blood* / Q000145:classification; D003124:Colorimetry; D003287:Contrast Media / Q000737:chemistry; D019786:Gadolinium DTPA / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020714:Maximum Tolerated Dose; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D010949:Plasma / Q000737:chemistry / Q000187:drug effects; D044967:Serum / Q000737:chemistry / Q000187:drug effects
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol; D019786:Gadolinium DTPA; D002118:Calcium