title: Effect of ferulic acid and Angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies.
abstract: OBJECTIVE
  The behavioral and psychological symptoms of dementia place a heavy burden on caregivers. Antipsychotic drugs, though used to reduce the symptoms, frequently decrease patients' activities of daily living and reduce their quality of life. Recently, it was suggested that ferulic acid is an effective treatment for behavioral and psychological symptoms. We have also reported several patients with dementia with Lewy bodies showing good responses to ferulic acid and Angelica archangelica extract (Feru-guard). The present study investigated the efficacy of Feru-guard in the treatment of behavioral and psychological symptoms in frontotemporal lobar degeneration and dementia with Lewy bodies.
  
  
  METHODS
  We designed a prospective, open-label trial of daily Feru-guard (3.0 g/day) lasting 4 weeks in 20 patients with frontotemporal lobar degeneration or dementia with Lewy bodies. Behavioral and psychological symptoms of dementia were assessed at baseline and 4 weeks after the start of treatment, using the Neuropsychiatric Inventory. The Neuropsychiatric Inventory scores were analyzed using the Wilcoxon rank sum test.
  
  
  RESULTS
  Treatment with Feru-guard led to decreased scores on the Neuropsychiatric Inventory in 19 of 20 patients and significantly decreased the score overall. The treatment also led to significantly reduced subscale scores on the Neuropsychiatric Inventory ("delusions", "hallucinations", "agitation/aggression", "anxiety", "apathy/indifference", "irritability/lability" and "aberrant behavior"). There were no adverse effects or significant changes in physical findings or laboratory data.
  
  
  CONCLUSIONS
  Feru-guard may be effective and valuable for treating the behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies.
authors.affiliation: Division of Clinical Research, National Hospital Organization Kikuchi Hospital, Kumamoto, Japan. tkimura@kikuti.hosp.go.jp
authors.forename: Takemi
authors.initials: T
authors.lastname: Kimura
authors.forename: Hideki
authors.initials: H
authors.lastname: Hayashida
authors.forename: Masako
authors.initials: M
authors.lastname: Murata
authors.forename: Junichi
authors.initials: J
authors.lastname: Takamatsu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D029970:Angelica archangelica; D001519:Behavior; D003373:Coumaric Acids / Q000627:therapeutic use*; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D020961:Lewy Body Disease / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D003373:Coumaric Acids; D010936:Plant Extracts; C004999:ferulic acid