title: Inpatient rehabilitation improved functional status in asthenic patients with solid and hematologic malignancies.
abstract: OBJECTIVE
  The aim of this study was to compare functional outcomes in asthenic patients with hematologic malignancies with those of asthenic patients with solid tumors after inpatient rehabilitation. We hypothesized that asthenic patients with hematologic malignancies are less likely than patients with solid tumors to make functional improvement after rehabilitation.
  
  
  METHODS
  The records of 60 asthenic cancer patients (30 consecutive patients with solid tumors and 30 consecutive patients with hematologic malignancies) who underwent inpatient rehabilitation at a comprehensive cancer center between October 2005 and October 2007 were retrospectively reviewed. Patients with focal neurologic deficits were excluded. All patients admitted to the inpatient rehabilitation unit received 3 hrs of more of therapy per weekday. The main outcomes included total, motor, and cognitive Functional Independence Measure (FIM) scores, hospital and rehabilitation length of stay, and FIM efficiency.
  
  
  RESULTS
  The mean total FIM score significantly improved in patients with solid tumors (mean, 15; range, -6 to 38) and in patients with hematologic malignancies (mean, 17; range, -3 to 27); however, between-group differences in FIM scores were not significant (P = 0.31). The solid tumor patients were significantly older than the hematologic malignancy patients (71 ± 11 vs. 64 ± 12 yrs; P = 0.02), but the mean rehabilitation lengths of stay were the same for each group (9.5 days; P = 0.82). The mean FIM efficiency in the hematologic malignancy group was higher than that of the solid tumor group (1.9 vs.1.4; P = 0.049).
  
  
  CONCLUSIONS
  Asthenic patients with solid tumors or hematologic malignancies could benefit from inpatient rehabilitation and make significant functional gain.
authors.affiliation: Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Ki Y
authors.initials: KY
authors.lastname: Shin
authors.forename: Susan
authors.initials: S
authors.lastname: Hainley
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bruera
authors.forename: J Lynn
authors.initials: JL
authors.lastname: Palmer
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001247:Asthenia / Q000209:etiology / Q000503:physiopathology* / Q000534:rehabilitation*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000534:rehabilitation*; D020127:Recovery of Function / Q000502:physiology*; D012047:Rehabilitation Centers; D016896:Treatment Outcome