title: [Polycystic ovary syndrome and miscarriage].
abstract: Polycystic ovary syndrome (PCOS) causes impaired fertility and is assumed to be associated with increased risk of miscarriage. This paper reviews the literature according to the principles of evidence-based medicine to establish whether PCOS and the clinical findings lead to an increased miscarriage rate. It is not possible to confirm any association between PCOS and miscarriage. Increased luteinizing hormone, androgens and plasminogen activator inhibitor-1 activity as well as obesity and impaired endometrial blood flow are to some degree associated with miscarriage.
authors.affiliation: Gynækologisk-obstetrisk Afdeling, Herlev Hospital, Denmark. s_pette@yahoo.dk
authors.forename: Mette Kirkelund
authors.initials: MK
authors.lastname: Truelsen
authors.forename: Helle Vibeke
authors.initials: HV
authors.lastname: Clausen
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D012307:Risk Factors