title: [Animal models for bone and joint disease. Osteoimmunology and animal models for rheumatoid arthritis].
abstract: Bone homeostasis is maintained by not only bone cells but also by various types of cells. Particularly, the skeletal system has an apparent relationship with the immune system, in that immune cells are generated in the bone marrow and that osteoclasts which play a crucial role in bone destruction differentiate from monocyte/macrophage lineage cells. In addition, investigation into rheumatoid arthritis (RA) has highlighted the relevance of the interplay between the bone and immune systems and promoted a new research field of 'osteoimmunology'. Here, we summarize how various animal models for RA contributed, and can contribute to the progress in osteoimmunology and increasing understanding of RA development and treatment.
authors.affiliation: Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
authors.forename: Noriko
authors.initials: N
authors.lastname: Komatsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takayanagi
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001842:Bone and Bones / Q000276:immunology*; D003094:Collagen / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D005620:Freund's Adjuvant / Q000276:immunology; D006706:Homeostasis; D053590:Interleukin 1 Receptor Antagonist Protein; D008070:Lipopolysaccharides; D051379:Mice; D008822:Mice, Transgenic; D010010:Osteoclasts / Q000502:physiology; D058504:Th17 Cells / Q000276:immunology; D048069:Tumor Necrosis Factors
chemical_list: D016207:Cytokines; D053590:Interleukin 1 Receptor Antagonist Protein; D008070:Lipopolysaccharides; D048069:Tumor Necrosis Factors; D003094:Collagen; D005620:Freund's Adjuvant