title: Risk factors for persistent gestational trophoblastic neoplasia.
abstract: This retrospective study evaluated the risk factors for persistent gestational trophoblastic disease (GTN) and determined their odds ratios. This study included 100 cases with GTN admitted to our clinic. Possible risk factors recorded were age, gravidity, parity, size of the neoplasia, and beta-human chorionic gonadotropin levels (beta-hCG) before and after the procedure. Statistical analyses consisted of the independent sample t-test and logistic regression using the statistical package SPSS ver. 15.0 for Windows (SPSS, Chicago, IL, USA). Twenty of the cases had persistent GTN, and the differences between these and the others cases were evaluated. The size of the neoplasia and histopathological type of GTN had no statistical relationship with persistence, whereas age, gravidity, and beta-hCG levels were significant risk factors for persistent GTN (p < 0.05). The odds ratios (95% confidence interval (CI)) for age, gravidity, and pre- and post-evacuation beta-hCG levels determined using logistic regression were 4.678 (0.97-22.44), 7.315 (1.16-46.16), 2.637 (1.41-4.94), and 2.339 (1.52-3.60), respectively. Patient age, gravidity, and beta-hCG levels were risk factors for persistent GTN, whereas the size of the neoplasia and histopathological type of GTN were not significant risk factors.
authors.affiliation: Dicle University, School of Medicine, Department of Obstetrics and Gynecology, Diyarbakir, Turkey.
authors.forename: Umur
authors.initials: U
authors.lastname: Kuyumcuoglu
authors.forename: Ali Irfan
authors.initials: AI
authors.lastname: Guzel
authors.forename: Mahmut
authors.initials: M
authors.lastname: Erdemoglu
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Celik
mesh_terms: D000293:Adolescent; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000209:etiology* / Q000473:pathology; D020073:Gravidity; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D010298:Parity; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human