title: [Treatment of lymphatic malformations with OK-432 sclerosis. Our experience].
abstract: BACKGROUND
  The elective treatment of lymphatic malformations has always been surgical resection. However sclerotherapy with a variety of substances is being used as an alternative to surgery specially in the last years. The aim of this essay is to present our results using sclerosis with OK-432.
  
  
  METHODS
  We have reviewed all patients affected by lymphatic malformation that have been treated by sclerosis with OK-432. Each procedure was performed under general anesthesia by a radiologist and a pediatric surgeon.
  
  
  RESULTS
  Fifteen patients have been treated. On the whole, 36 procedures have been performed, with a mean of 2.4 for each patient. The mean amount of OK-432 injected was 1.5 milligrams (mg) in each procedure. 73% of the patients showed nearly complete or complete response. There were two complications; one of them was a limited bleeding and the other one, a case of high fever resolved by antipyretics and antibiotics. Microcystic or mixed malformations required a higher number of procedures and presented poorer response.
  
  
  CONCLUSIONS
  Sclerotherapy with OK-432 is an effective and safe treatment for lymphatic malformation specially the macrocystic ones, therefore it should be considered as first line therapeutic option.
authors.affiliation: Servicio de Cirugía Pediátrica, Hospital Universitario 12 de Octubre, Madrid. sarafuentesc@yahoo.es
authors.forename: S
authors.initials: S
authors.lastname: Fuentes
authors.forename: D
authors.initials: D
authors.lastname: Delgado
authors.forename: E
authors.initials: E
authors.lastname: Martí
authors.forename: M C
authors.initials: MC
authors.lastname: Gallego
authors.forename: R
authors.initials: R
authors.lastname: Tejedor
authors.forename: C
authors.initials: C
authors.lastname: Moreno
authors.forename: A
authors.initials: A
authors.lastname: Gómez
mesh_terms: D002648:Child; D000013:Congenital Abnormalities / Q000628:therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000002:abnormalities*; D008297:Male; D010844:Picibanil / Q000627:therapeutic use*; D012597:Sclerosing Solutions / Q000627:therapeutic use*
chemical_list: D012597:Sclerosing Solutions; D010844:Picibanil