title: [Visfatin in obese patients, relation with cardiovascular risk factors, a cross sectional study].
abstract: OBJECTIVE
  Obesity and insulin resistance are associated with cardiovascular risk factors. The aim of the present study was to explore the relation of visfatin with insulin resistance, cardiovascular risk factors and anthropometry in obese patients without comorbidities.
  
  
  METHODS
  A population of 270 obese patients was analyzed in a prospective way. In all patients we performed a biochemical analysis (lipid profile, insulin, HOMA and visfatina), and a nutritional evaluation (dietary intake, conventional anthropometry and bioimpedance).
  
  
  RESULTS
  Patients were divided in two groups by median visfatin value (8,32 ng/ml), group I (patients with the low values, average value 7,11 (0,7) ng/ml) and group II (patients with the high values, average value 13,5 (10,1) ng/ml). Patients in the group I had higher weight, body mass index, waist circumference, and waist to hip ratio than patients in group II. Patients in group I had lower LDL-cholesterol and C reactive protein than patients in group II. Correlation analysis showed a positive correlation between visfatin levels and LDL cholesterol (r=0.194; p<0.05) and C reactive protein (r=0.266; p<0.05) and a negative corelation with weight (r=-0.162; p<0.05). In the logistic analysis with age-, sex- and dietary intake- adjusted basal visfatin concentration as a dependent variable, the next variables remained in the model; weight with an odds ratio (OR) 0,97 (IC95% 0,95-0,99), LDL cholesterol 1,012(1,010-1.023) and C reactive protein 1,15 (1.03-1.3).
  
  
  CONCLUSIONS
  LDL cholesterol and c reactive protein levels are positively correlated with visfatin levels. Weight is negatively correlated with visfatin levels, in an independent way and adjusted by age, sex and dietary intake.
authors.affiliation: Centro de Investigación en Endocrinología y Nutrición Clínica, Facultad de Medicina y Unidad de Investigacion, Hospital Universitario Río Hortega, Universidad de Valladolid, Valladolid, España. roaller@yahoo.es
authors.forename: Daniel A
authors.initials: DA
authors.lastname: de Luis
authors.forename: María
authors.initials: M
authors.lastname: Ballesteros
authors.forename: Enrique
authors.initials: E
authors.lastname: Ruiz
authors.forename: Carmen
authors.initials: C
authors.lastname: Muñoz
authors.forename: Angeles
authors.initials: A
authors.lastname: Penacho
authors.forename: Pedro
authors.initials: P
authors.lastname: Iglesias
authors.forename: Antonio López
authors.initials: AL
authors.lastname: Guzmán
authors.forename: Cristina
authors.initials: C
authors.lastname: Abreu
authors.forename: Alfonso
authors.initials: A
authors.lastname: Maldonado
authors.forename: Manuel
authors.initials: M
authors.lastname: Delgado
authors.forename: Lucía San
authors.initials: LS
authors.lastname: Martín
authors.forename: Victor
authors.initials: V
authors.lastname: Puigdevall
authors.forename: Enrique
authors.initials: E
authors.lastname: Romero
authors.forename: Manuel González
authors.initials: MG
authors.lastname: Sagrado
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: Rosa
authors.initials: R
authors.lastname: Conde
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D015930:Diet Records; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D008055:Lipids; D054409:Nicotinamide Phosphoribosyltransferase