title: The utility of hemoglobin A1c at diagnosis for prediction of future glycemic control in children with type 1 diabetes.
abstract: BACKGROUND
  We evaluated the relationships of hemoglobin A1c (A1c) at diagnosis of type 1 diabetes (T1DM) to future glycemic control and to a series of clinical variables in children with T1DM.
  
  
  METHODS
  Patients <18 years old diagnosed with T1DM during a one year period who had an A1c at diagnosis and at least one follow-up visit at our center were eligible for inclusion. Baseline variables examined included age, race, gender, symptom duration, admission acuity, anthropometrics, bicarbonate, and A1c. Annual anthropometric and A1c data were also obtained from clinic visits through 4 years after diagnosis.
  
  
  RESULTS
  We identified 120 children (53 males). Mean age at diagnosis was 7.6±3.9 years. Mean A1c at diagnosis was 10.9±1.9%. A1c at diagnosis correlated with age at diagnosis, symptom duration, and A1c at 3-years, with trends towards correlations at 6 weeks and 4 years. A1c at 1 year correlated highly with A1c at subsequent visits. No other baseline variables correlated with subsequent glycemic control.
  
  
  CONCLUSIONS
  In children with newly diagnosed diabetes, A1cs at diagnosis and one year post diagnosis are related to subsequent glycemic control. Children with high A1cs particularly at one year post diagnosis may benefit from targeted intensification of resources.
authors.affiliation: Section of Pediatric Endocrinology/Diabetology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, United States. vviswana@iupui.edu
authors.forename: Vidhya
authors.initials: V
authors.lastname: Viswanathan
authors.forename: M Rhonda
authors.initials: MR
authors.lastname: Sneeringer
authors.forename: Adam
authors.initials: A
authors.lastname: Miller
authors.forename: Erica A
authors.initials: EA
authors.lastname: Eugster
authors.forename: Linda A
authors.initials: LA
authors.lastname: DiMeglio
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin