title: Glucose tolerance of premenopausal women after menopause due to surgical removal of ovaries.
abstract: OBJECTIVE
  To evaluate the influence of the abrupt withdrawal of ovarian function on glucose tolerance by studying premenopausal women before and after oophorectomy.
  
  
  METHODS
  Thirty premenopausal women who needed hysterectomy for benign reasons volunteered for the study in our hospital in Istanbul, Turkey. An oral glucose tolerance test (OGTT) was performed before surgery and 3, 6 and 12 months after surgery. Fasting glucose, fasting insulin levels and insulin/glucose indexes, HOMA indexes, insulin and glucose levels were measured during OGTT.
  
  
  RESULTS
  The mean fasting and 2-h glucose levels of the women did not change significantly during the 12 months of follow-up. However, the glucose levels during the glucose tolerance tests changed significantly after surgery (p<0.05). Insulin responses to the glucose tolerance test also increased significantly (p<0.005). Insulin/glucose indexes were significantly higher after surgery (p<0.005). Type 2 diabetes mellitus was detected in five women and impaired glucose tolerance was detected in 12 of the 30 patients after surgery in the 12-month period.
  
  
  CONCLUSIONS
  The impairment of carbohydrate metabolism due to an abrupt decrease in natural estrogen levels should be considered before removing the ovaries during hysterectomy in premenopausal patients.
authors.affiliation: Obstetrics and Gynecology Department of Dr. Lutfi Kirdar Kartal Education and Research Hospital, Kartal, Istanbul, Turkey.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Pirimoglu
authors.forename: C
authors.initials: C
authors.lastname: Arslan
authors.forename: E E
authors.initials: EE
authors.lastname: Buyukbayrak
authors.forename: B
authors.initials: B
authors.lastname: Kars
authors.forename: Y K
authors.initials: YK
authors.lastname: Karsidag
authors.forename: O
authors.initials: O
authors.lastname: Unal
authors.forename: M C
authors.initials: MC
authors.lastname: Turan
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis; D005951:Glucose Tolerance Test; D006801:Humans; D007044:Hysterectomy; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008594:Menopause, Premature / Q000097:blood*; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects*; D014421:Turkey
chemical_list: D001786:Blood Glucose; D007328:Insulin