title: [Bioinformatic analysis of genes related to temporal epilepsy].
abstract: OBJECTIVE
  To investigate the genes associated with temporal epilepsy and explore the molecular mechanism of epilepsy.
  
  
  METHODS
  The microarray data of temporal epilepsy were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases.
  
  
  RESULTS
  Of all the 71 differentially expressed genes, 51 were found to encode proteins with interactions; the main biological pathways involved included neuroactive ligand-receptor interactions, MAPK signaling pathway, and calcium signaling pathway etc.
  
  
  CONCLUSIONS
  The pathogenesis of epilepsy involves multiple genes, and investigations of these genes may provide valuable insights into the mechanism of epilepsy.
authors.affiliation: Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. lzhouye@126.com
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.forename: Yong
authors.initials: Y
authors.lastname: Bao
authors.forename: Chang-zheng
authors.initials: CZ
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Xie
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Zheng
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Ma
mesh_terms: D019295:Computational Biology / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis