title: High-throughput tools for the study of protein-nanostructured surface interaction.
abstract: The aim of this review is to describe and to analyze the ingredients that are necessary in order to develop a robust and effective experimental approach for the high-throughput characterization of protein-nanostructured surface interaction. In the first part of this paper we review the nanostructured surface synthesis methods that are potentially able to create nanostructured inorganic surface libraries. In the second part, we address another fundamental aspect consisting in the availability of high-throughput proteins detection methods. We describe in details new emerging analytical tools compatible with nanostructured surfaces, analyzing different possible strategies, depending on the objective of the experiment and on the library format.
authors.affiliation: Interdisciplinary Centre for Nanostructured Materials and Interfaces, Physics Department, Università degli Studi di Milano, Milan, Italy.
authors.forename: Pasquale Emanuele
authors.initials: PE
authors.lastname: Scopelliti
authors.forename: Gero
authors.initials: G
authors.lastname: Bongiorno
authors.forename: Paolo
authors.initials: P
authors.lastname: Milani
mesh_terms: D020650:Combinatorial Chemistry Techniques; D057166:High-Throughput Screening Assays; D049329:Nanostructures / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D054852:Small Molecule Libraries; D013499:Surface Properties
chemical_list: D011506:Proteins; D054852:Small Molecule Libraries