title: Cancer-cell-specific cytotoxicity of non-oxidized iron elements in iron core-gold shell NPs.
abstract: Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 μg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This novel nanomaterial holds great promise as a therapeutic tool in nanomedicine.
  
  
  BACKGROUND
  Gold-coated iron nanoparticles (NPs) selectively suppressed squamous cell carcinoma (SCC) and colorectal cancer (CRC) cell growth, but left healthy control cells unaffected both in vitro and in vivo. The particles were equally uptaken by all cells, but delayed cell progression only for cancer cells. The origin is related to the iron core: neither iron ions nor the oxidized NPs have the same outcome.
authors.affiliation: Australian Centre for Microscopy and Microanalysis, The University of Sydney, NSW, Australia.
authors.forename: Ya-Na
authors.initials: YN
authors.lastname: Wu
authors.forename: Dong-Hwang
authors.initials: DH
authors.lastname: Chen
authors.forename: Xian-Yu
authors.initials: XY
authors.lastname: Shi
authors.forename: Chiao-Ching
authors.initials: CC
authors.lastname: Lian
authors.forename: Ting-Yu
authors.initials: TY
authors.lastname: Wang
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Yeh
authors.forename: Kyle R
authors.initials: KR
authors.lastname: Ratinac
authors.forename: Pall
authors.initials: P
authors.lastname: Thordarson
authors.forename: Filip
authors.initials: F
authors.lastname: Braet
authors.forename: Dar-Bin
authors.initials: DB
authors.lastname: Shieh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009062:Mouth Neoplasms / Q000188:drug therapy; D036103:Nanotechnology / Q000379:methods*; D013054:Spectrophotometry, Atomic
chemical_list: D000970:Antineoplastic Agents; D006046:Gold; D007501:Iron