title: The TRPC ion channels: association with Orai1 and STIM1 proteins and participation in capacitative and non-capacitative calcium entry.
abstract: Transient receptor potential (TRP) proteins are involved in a large number of non-selective cation channels that are permeable to both monovalent and divalent cations. Two general classes of receptor-mediated Ca(2+) entry has been proposed: one of then is conduced by receptor-operated Ca(2+) channels (ROC), the second is mediated by channels activated by the emptying of intracellular Ca(2+) stores (store-operated channels or SOC). TRP channels have been presented as subunits of both ROC and SOC, although the precise mechanism that regulates the participation of TRP proteins in these Ca(2+) entry mechanisms remains unclear. Recently, TRPC proteins have been shown to associate with Orai1 and STIM1 in a dynamic ternary complex regulated by the occupation of membrane receptors in several cell models, which might play an important role in the function of TRPC proteins. The present review summarizes the current knowledge concerning the association of TRP proteins with Orai and STIM proteins and how this affects the participation of TRP proteins in store-operated or receptor-operated Ca(2+) entry.
authors.affiliation: Cell Physiology Group, Department of Physiology, University of Extremadura, Cáceres, Spain. gsalido@unex.es
authors.forename: Gines M
authors.initials: GM
authors.lastname: Salido
authors.forename: Isaac
authors.initials: I
authors.lastname: Jardín
authors.forename: Juan A
authors.initials: JA
authors.lastname: Rosado
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology*; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D017136:Ion Transport; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology*; D000071740:ORAI1 Protein; D000071737:Stromal Interaction Molecule 1; D050051:Transient Receptor Potential Channels / Q000378:metabolism / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C103530:STIM1 protein, human; C502662:Stim protein, Drosophila; D000071737:Stromal Interaction Molecule 1; D050051:Transient Receptor Potential Channels; C510747:olf186-F protein, Drosophila; D002118:Calcium