title: Investigation on injectable, thermally and physically gelable poly(ethylene glycol)/poly(octadecanedioic anhydride) amphiphilic triblock co-polymer nanoparticles.
abstract: A family of injectable, biodegradable and thermosensitive co-polymer nanoparticle (NP) hydrogels based on mPEG-b-POA-b-mPEG, which was synthesized from mono-methoxy poly(ethylene glycol) (mPEG) and poly(octadecanedioic anhydride) (POA), was investigated in this paper.  It was found that the aqueous dispersions of these NPs underwent a reversible gel-sol transition upon temperature change. By using paclitaxel and Bovine serum albumin (BSA) as model drugs, we noticed that the in vitro releases of both in situ gel-forming formulations were  sustained and no initial burst releases were observed for 7 days. In vitro cytotoxicity tests via MTT assay indicate that mPEG-b-POA-b-mPEG NPs are non-toxic to normal mouse lung fibroblast cells (L929). The in vivo hydrogel formation and in vivo biocompatibility  of co-polymer NP hydrogel were also investigated and the results further validate the biocompatible nature of co-polymer NP hydrogel. In conclusion, our mPEG-b-POA-b-mPEG NP hydrogel is able to control the release of incorporated drug for longer duration.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China.
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Liang
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiao
authors.forename: Shutao
authors.initials: S
authors.lastname: Guo
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yinglei
authors.initials: Y
authors.lastname: Zhai
authors.forename: Chaopeng
authors.initials: C
authors.lastname: Xie
authors.forename: Renjie
authors.initials: R
authors.lastname: Hu
authors.forename: Liandong
authors.initials: L
authors.lastname: Deng
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D000818:Animals; D002417:Cattle; D002460:Cell Line; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry* / Q000633:toxicity; D005782:Gels; D057927:Hydrophobic and Hydrophilic Interactions; D007249:Inflammation / Q000139:chemically induced; D007267:Injections; D008422:Materials Testing; D051379:Mice; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry* / Q000633:toxicity; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013229:Stearic Acids / Q000737:chemistry*; D013696:Temperature
chemical_list: D000812:Anhydrides; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; D013229:Stearic Acids; C529486:poly(octadecanoic anhydride); D011092:Polyethylene Glycols