title: Evaluation of antiviral activities of curcumin derivatives against HSV-1 in Vero cell line.
abstract: Antiviral drug resistance is one of the most common problems in medicine, and, therefore, finding new antiviral agents, especially from natural resources, seems to be necessary. This study was designed to assay the antiviral activity of curcumin and its new derivatives like gallium-curcumin and Cu-curcumin on replication of HSV-1 in cell culture. The research was performed as an in vitro study in which the antiviral activity of different concentrations of three substances including curcumin, Gallium-curcumin and Cu-curcumin were tested on HSV-1. The cytotoxicity of the tested compounds was also evaluated on the Vero cell line. The CC50 values for curcumin, gallium-curcumin and Cu-curcumin were 484.2 microg/mL, 255.8 microg/mL and 326.6 microg/mL, respectively, and the respective IC50 values 33.0 microg/mL, 13.9 microg/mL and 23.1 microg/mL. The calculated SI values were 14.6, 18.4 and 14.1, respectively. The results showed that curcumin and its new derivatives have remarkable antiviral effects on HSV-1 in cell culture.
authors.affiliation: The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. zandi@bpums.ac.ir
authors.forename: Keivan
authors.initials: K
authors.lastname: Zandi
authors.forename: Elissa
authors.initials: E
authors.lastname: Ramedani
authors.forename: Khosro
authors.initials: K
authors.lastname: Mohammadi
authors.forename: Saeed
authors.initials: S
authors.lastname: Tajbakhsh
authors.forename: Iman
authors.initials: I
authors.lastname: Deilami
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rastian
authors.forename: Moradali
authors.initials: M
authors.lastname: Fouladvand
authors.forename: Forough
authors.initials: F
authors.lastname: Yousefi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Farshadpour
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D003474:Curcumin