title: Effects of subchronic aluminum exposure on the immune function of erythrocytes in rats.
abstract: This study assessed effects of aluminum (Al) exposure on the immune function of erythrocytes in rats. Forty male Wistar rats (5 weeks old) weighed 110-120 g were randomly allocated equally into four groups according to their weights and were orally exposed to 0, 64.18, 128.36, and 256.72 mg/kg body weight aluminum trichloride in drinking water for 120 days. Levels of erythrocytes C(3b) receptor rate (RBC-C(3b)RR), erythrocytes C(3b) immune complex rosette rate (RBC-ICR), erythrocytes rosette forming enhancing rate (ERER) and erythrocytes rosette forming inhibitory rate (ERIR) were determined by the end of experiment. The three Al-treated groups had lower values of RBC-C(3b)RR and ERER, and higher values of RBC-ICR and ERIR than those in control group. The levels of RBC-C(3b)RR and ERER decreased, while the levels of RBC-ICR and ERIR increased with the increases of Al content in drinking water. The results suggest that the immune function of erythrocytes in rats is suppressed by Al exposure.
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.
authors.forename: Yanzhu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Hansong
authors.initials: H
authors.lastname: Zhao
authors.forename: Xinwei
authors.initials: X
authors.lastname: Li
authors.forename: Lichao
authors.initials: L
authors.lastname: Zhang
authors.forename: Chongwei
authors.initials: C
authors.lastname: Hu
authors.forename: Bing
authors.initials: B
authors.lastname: Shao
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Alphajoh A
authors.initials: AA
authors.lastname: Bah
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Li
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012397:Rosette Formation
chemical_list: D000535:Aluminum