title: A rare lung nodule consisting of adenocarcinoma and amyloid deposition in a patient with primary systemic AL amyloidosis.
abstract: A 60-year-old woman was found to have proteinuria and a lung nodule. The surgically resected left upper lobe contained a nodule, in which the adenocarcinoma was surrounded by a heavy deposition of amyloid. Subsequent renal and gastric biopsies demonstrated amyloid deposition with Aλ immunoreactivity. She was treated with 2 courses of VAD (vincristine, doxorubicin and dexamethasone), resulting in the disappearance of Bence Jones proteinuria. Her nephrotic syndrome has been improving during the subsequent 3 years. The rare lung nodule consisting of adenocarcinoma and amyloid deposition was a diagnostic clue in this primary systemic AL amyloidosis patient.
authors.affiliation: Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
authors.forename: Daigo
authors.initials: D
authors.lastname: Miyazaki
authors.forename: Masahide
authors.initials: M
authors.lastname: Yazaki
authors.forename: Wataru
authors.initials: W
authors.lastname: Ishii
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hoshii
authors.forename: Kenji
authors.initials: K
authors.lastname: Nara
authors.forename: Jun
authors.initials: J
authors.lastname: Nakayama
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001706:Biopsy; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D008875:Middle Aged; D011013:Pneumonectomy; D013270:Stomach / Q000473:pathology; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000682:Amyloid; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin