title: Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics.
abstract: It is well-known that cell cycle arrest and/or death play a pivotal role in tumor progression, which has drawn a rising attention for cancer biologists due to their complex and intricate relationships. In this review, we demonstrate the recent research on oridonin, an active diterpenoid with remarkable anti-proliferative activities, and then further explore its molecular mechanisms of cell cycle arrest, apoptosis, autophagy and their cross-talks in various cancer cells, which may provide a new perspective of oridonin as a candidate anti-neoplastic drug for future cancer therapeutics.
authors.affiliation: School of Life Sciences & State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610064, China.
authors.forename: Chun-yang
authors.initials: CY
authors.lastname: Li
authors.forename: En-qin
authors.initials: EQ
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Jin-ku
authors.initials: JK
authors.lastname: Bao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001343:Autophagy / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004355:Drug Stability; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D045786:Diterpenes, Kaurane; C011959:oridonin