title: A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles.
abstract: Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Smith
authors.forename: Nikzad
authors.initials: N
authors.lastname: Nikbin
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Heiko
authors.initials: H
authors.lastname: Lange
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale