title: Reduction in thigh circumference and improvement in the appearance of cellulite with dual-wavelength, low-level laser energy and massage.
abstract: OBJECTIVE
  This study evaluated the efficacy and safety of a low-level, dual-wavelength laser energy and massage device for improving the appearance of cellulite and reducing thigh circumference.
  
  
  METHODS
  Subjects (n = 83) with mild to moderate cellulite enrolled in this IRB-approved, open-label, multicenter study. Their right or left thighs received eight treatments with a low-level, dual-wavelength laser and massage device. The untreated contralateral thigh served as a control. Circumferences of the upper, middle, and lower thighs (treated and untreated) were measured before the fifth and eighth treatments and 1 month after the final treatment.
  
  
  RESULTS
  Reduction in thigh circumference of the treated areas exceeded those of the control areas for the upper, middle, and lower thigh in most subjects. The maximum reduction (-0.82 cm) occurred in the upper thigh at 1 month. The mean reduction of the upper, middle, and lower thigh circumferences was -0.64 cm for the treated thighs compared to -0.20 cm for untreated thighs. The difference was significant (p < 0.0001). Fifty-nine (71.1%) treatment thighs lost circumference compared to 44 (53.0%) control thighs. Resolution of adverse effects including erythema, swelling, and increased urination was seen within 30 minutes after treatment. All were resolved without sequelae and within the expected duration.
  
  
  CONCLUSIONS
  The low-level, dual-wavelength laser energy and massage device safely improves the appearance of cellulite while reducing thigh circumference.
authors.affiliation: Tennessee Clinical Research Center, 2000 Richard Jones Road, Nashville, TN 37215, USA. goldskin@goldskincare.com
authors.forename: Michael H
authors.initials: MH
authors.lastname: Gold
authors.forename: Khalil A
authors.initials: KA
authors.lastname: Khatri
authors.forename: Kelley
authors.initials: K
authors.lastname: Hails
authors.forename: Robert A
authors.initials: RA
authors.lastname: Weiss
authors.forename: Nathalie
authors.initials: N
authors.lastname: Fournier
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D003357:Cosmetic Techniques; D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods*; D008405:Massage / Q000295:instrumentation / Q000379:methods*; D013848:Thigh / Q000033:anatomy & histology*