title: Anti-cytokine therapies for psoriasis.
abstract: Current approaches for the treatment of psoriasis with anti-cytokine therapies involve the blockade of TNF-α, or the p40 sub-unit of IL-12 and IL-23. However, the field is currently evolving to test more selective antagonists, such as anti-IL-23p19, IL-17 and other inflammatory cytokines. Here we discuss our current understanding of dendritic cell and T cell subsets that are relevant in psoriasis, and the pharmacologic strategies that temper their activity in this disease.
authors.affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA.
authors.forename: Kristine E
authors.initials: KE
authors.lastname: Nograles
authors.forename: James G
authors.initials: JG
authors.lastname: Krueger
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D021122:Protein Subunits / Q000276:immunology; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000906:Antibodies; D016207:Cytokines; D021122:Protein Subunits