title: Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice.
abstract: To see whether age-related changes in bone could predict subsequent lifespan, we measured multiple aspects of femur size and shape at 4, 15, and 24 months of age in genetically heterogeneous mice. Mice whose cortical bone became thicker from 4 to 15 months, associated with preservation of the endosteal perimeter, survived longer than mice whose endosteal cavity expanded, at the expense of cortical bone, over this age range. Femur size at age 4 months was also associated with a difference in life expectancy: mice with larger bones (measured by length, cortical thickness, or periosteal perimeter) had shorter lifespans. Femur length, midlife change in cortical bone thickness, and midlife values of CD8 T memory cells each added significant power for longevity prediction. Mice in the upper half of the population for each of these three endpoints lived, on average, 103 days (12%) longer than mice with the opposite characteristics. Thus, measures of young adult bone dimensions, changes as a result of bone remodeling in middle age, and immunological maturation provide partially independent indices of aging processes that together help to determine lifespan in genetically heterogeneous mice.
authors.affiliation: Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, USA. millerr@umich.edu
authors.forename: Richard A
authors.initials: RA
authors.lastname: Miller
authors.forename: Jaclynn
authors.initials: J
authors.lastname: Kreider
authors.forename: Andrzej
authors.initials: A
authors.lastname: Galecki
authors.forename: Steven A
authors.initials: SA
authors.lastname: Goldstein
mesh_terms: D000375:Aging / Q000235:genetics / Q000276:immunology*; D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D015519:Bone Density / Q000235:genetics / Q000276:immunology; D001846:Bone Development / Q000235:genetics / Q000276:immunology; D016723:Bone Remodeling / Q000235:genetics / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D003433:Crosses, Genetic; D005260:Female; D005269:Femur; D018740:Genetic Heterogeneity; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis* / Q000276:immunology; D007156:Immunologic Memory; D008017:Life Expectancy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000235:genetics / Q000276:immunology; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D018960:Hyaluronan Receptors