title: Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T).
abstract: PARK8 is the most common form of familial Parkinson's disease (PD). We measured biopterin and monoamine metabolite levels in the cerebrospinal fluids of 7 PARK8 patients (I2020T mutation in leucine-rich repeat kinase 2), 2 asymptomatic mutation carriers, and 21 sporadic PD patients. The biopterin levels in PARK8 patients were significantly higher than those in sporadic PD patients, although the symptoms were comparable in both groups, suggesting that PARK8 patients exhibit parkinsonian symptoms with higher biopterin levels than sporadic PD patients.
authors.affiliation: Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259-B7 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Koshiba
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tokuoka
authors.forename: Teruo
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Emiko
authors.initials: E
authors.lastname: Horiuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ichinose
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hasegawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001708:Biopterins / Q000134:cerebrospinal fluid*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D001708:Biopterins