title: HbA1c in nondiabetic Dutch infants aged 8-12 months: the GECKO-Drenthe birth cohort study.
abstract: OBJECTIVE
  An international committee of experts recommended using HbA(1c) for diagnostic testing for diabetes. Little is known about normal values of HbA(1c) in infants. The aim of this study is to describe the distribution of HbA(1c) in 8- to 12-month-old nondiabetic infants.
  
  
  METHODS
  HbA(1c) was measured in 86 infants participating in the Groningen Expert Center for Kids with Obesity (GECKO)-Drenthe birth cohort study. Anthropometric measurements were performed at Well Baby Clinics. Data on parents and children were collected prospectively using questionnaires.
  
  
  RESULTS
  HbA(1c) was normally distributed with a mean (SD) HbA(1c) level of 5.38% (0.24), range 4.8-6.0% or 35.29 mmol/mol (2.65), range 29.1-42.1 mmol/mol. Age, sex, birth weight, duration of breastfeeding, anthropometric measurements, and maternal BMI were not associated with HbA(1c).
  
  
  CONCLUSIONS
  We found a normal distribution of HbA(1c) with a relatively high mean HbA(1c) of 5.38%. No significant association between risk factors for type 2 diabetes and HbA(1c) levels was found.
authors.affiliation: Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. h.jansen@epi.umcg.nl
authors.forename: Hanneke
authors.initials: H
authors.lastname: Jansen
authors.forename: Haika G
authors.initials: HG
authors.lastname: Huiting
authors.forename: Salome
authors.initials: S
authors.lastname: Scholtens
authors.forename: Pieter J J
authors.initials: PJ
authors.lastname: Sauer
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Stolk
mesh_terms: D000704:Analysis of Variance; D002624:Chemistry, Clinical / Q000592:standards*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011237:Predictive Value of Tests; D015995:Prevalence; D012016:Reference Values; D012307:Risk Factors
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human