title: Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
abstract: High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
authors.affiliation: Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Lindström
authors.forename: Celine M
authors.initials: CM
authors.lastname: Vachon
authors.forename: Jingmei
authors.initials: J
authors.lastname: Li
authors.forename: Jajini
authors.initials: J
authors.lastname: Varghese
authors.forename: Deborah
authors.initials: D
authors.lastname: Thompson
authors.forename: Ruth
authors.initials: R
authors.lastname: Warren
authors.forename: Judith
authors.initials: J
authors.lastname: Brown
authors.forename: Jean
authors.initials: J
authors.lastname: Leyland
authors.forename: Tina
authors.initials: T
authors.lastname: Audley
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
authors.forename: Ruth J F
authors.initials: RJ
authors.lastname: Loos
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Paterson
authors.forename: Johanna
authors.initials: J
authors.lastname: Rommens
authors.forename: Darryl
authors.initials: D
authors.lastname: Waggott
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Martin
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Scott
authors.forename: V Shane
authors.initials: VS
authors.lastname: Pankratz
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: Aditi
authors.initials: A
authors.lastname: Hazra
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Isabel dos Santos
authors.initials: Idos S
authors.lastname: Silva
authors.forename: JianJun
authors.initials: J
authors.lastname: Liu
authors.forename: Louise
authors.initials: L
authors.lastname: Eriksson
authors.forename: Fergus J
authors.initials: FJ
authors.lastname: Couch
authors.forename: Jennifer
authors.initials: J
authors.lastname: Stone
authors.forename: Carmel
authors.initials: C
authors.lastname: Apicella
authors.forename: Kamila
authors.initials: K
authors.lastname: Czene
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Per
authors.initials: P
authors.lastname: Hall
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Norman F
authors.initials: NF
authors.lastname: Boyd
authors.forename: Rulla M
authors.initials: RM
authors.lastname: Tamimi
mesh_terms: D000483:Alleles; D001940:Breast / Q000033:anatomy & histology*; D001943:Breast Neoplasms / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012306:Risk; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; C475725:ZNF365 protein, human