title: Three new flavonoids from the active extract of Fallopia convolvulus.
abstract: Five solvent extracts (ethanol, petroleum ether, EtOAC, n-butanol, and water) from Fallopia convolvulus (L.) Love were separated and their inhibitory effects on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated. Three new flavonoids, falloconvolin A (1), falloconvolin B (2), and quercetin-3-O-(2-E-sinapoxyl)-glucopyranoside (3), together with 17 known phenolic compounds, were isolated from the active EtOAC extract, and their structures were elucidated on the basis of spectroscopic analysis and literature data.
authors.affiliation: Key Laboratory of Modern Chinese Medicines, Ministry of Education, Research Department of Pharmacognosy, China Pharmaceutical University, Nanjing, China. njchaofeng@126.com
authors.forename: Chao-Feng
authors.initials: CF
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Li-Qing
authors.initials: LQ
authors.lastname: Zhao
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Mian
authors.initials: M
authors.lastname: Zhang
authors.forename: Zheng-Tao
authors.initials: ZT
authors.lastname: Wang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D019664:Polygonaceae / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005960:Glucosides; D008070:Lipopolysaccharides; C556208:falloconvolin A; C556209:falloconvolin B; C556210:quercetin-3-O-(2-E-sinapoxyl)-glucopyranoside; D009569:Nitric Oxide; D011794:Quercetin