title: Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.
abstract: Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.
authors.affiliation: Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Jarrod R
authors.initials: JR
authors.lastname: Fortwendel
authors.forename: Praveen R
authors.initials: PR
authors.lastname: Juvvadi
authors.forename: Luise E
authors.initials: LE
authors.lastname: Rogg
authors.forename: William J
authors.initials: WJ
authors.lastname: Steinbach
mesh_terms: D001232:Aspergillus fumigatus / Q000166:cytology* / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development*; D016764:Cell Polarity; D048430:Cell Shape; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D025301:Hyphae / Q000378:metabolism / Q000648:ultrastructure; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D018631:ras Proteins