title: DNA-capped nanoparticles designed for doxorubicin drug delivery.
abstract: The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.
authors.affiliation: Department of Chemistry, Syracuse University, 111 College Pl., Syracuse, NY 13244-4100, USA.
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Alexander
authors.forename: Mathew M
authors.initials: MM
authors.lastname: Maye
authors.forename: James C
authors.initials: JC
authors.lastname: Dabrowiak
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002417:Cattle; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004317:Doxorubicin / Q000378:metabolism*; D004337:Drug Carriers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D013379:Substrate Specificity
chemical_list: D004337:Drug Carriers; D006046:Gold; D004317:Doxorubicin; D004247:DNA