title: Activity of the fluoroquinolone DC-159a in the initial and continuation phases of treatment of murine tuberculosis.
abstract: DC-159a is a new fluoroquinolone with more potent in vitro activity than available fluoroquinolones against both drug-susceptible and fluoroquinolone-resistant Mycobacterium tuberculosis. Here, we report that DC-159a displays pharmacokinetics similar to those of moxifloxacin yet is more active than moxifloxacin during both the initial and continuation phases of treatment in a murine model. These results warrant further preclinical evaluation of DC-159a in selected drug combinations against drug-susceptible and fluoroquinolone-resistant tuberculosis.
authors.affiliation: Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
authors.forename: Zahoor
authors.initials: Z
authors.lastname: Ahmad
authors.forename: Austin
authors.initials: A
authors.lastname: Minkowski
authors.forename: Charles A
authors.initials: CA
authors.lastname: Peloquin
authors.forename: Kathy N
authors.initials: KN
authors.lastname: Williams
authors.forename: Khisimuzi E
authors.initials: KE
authors.lastname: Mdluli
authors.forename: Jacques H
authors.initials: JH
authors.lastname: Grosset
authors.forename: Eric L
authors.initials: EL
authors.lastname: Nuermberger
mesh_terms: D000631:Aminopyridines / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000995:Antitubercular Agents / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: C530475:7-(7-amino-7-methyl-5-azaspiro(2.4)heptan-5-yl)-6-fluoro-1-(2-fluoro-1-cyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; D000631:Aminopyridines; D000995:Antitubercular Agents; D024841:Fluoroquinolones