title: A facile direct anti-selective catalytic asymmetric Mannich reaction of aldehydes with preformed N-Boc and N-Cbz imines.
abstract: Anti-selective Mannich reactions of N-Boc and N-Cbz protected imines with unmodified aldehydes proceeded smoothly under the catalysis of a secondary amine-thiourea catalyst, which led to high yields (70%-95%) and excellent enantioselectivity (up to 96 : 4 dr and >99% ee) under conventional organic synthetic operations.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, P.R. China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Chuan
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Chen
authors.forename: Jiu-Zhi
authors.initials: JZ
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Yun-Gui
authors.initials: YG
authors.lastname: Peng