title: Comparative protective action of curcumin, memantine and diclofenac against scopolamine-induced memory dysfunction.
abstract: The comparative preventive effect of curcumin, memantine, and diclofenac on scopolamine-induced memory dysfunction was investigated in a controlled study. A group of male and female rats was treated with one of these compounds for 15 days, after which a single dosage of scopolamine was administered. The preventive activity of curcumin on memory dysfunction was higher than that of diclofenac or memantine, that was, however, administered at lower dosages. Gender differences were observed.
authors.affiliation: Zoology Department, Women College, for Arts, Science and Education, Ain Shams University, Cairo, Egypt. elhamhassan2006@yahoo.com
authors.forename: Elham H A
authors.initials: EH
authors.lastname: Ali
authors.forename: Nadia M S
authors.initials: NM
authors.lastname: Arafa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018680:Cholinergic Antagonists; D003474:Curcumin / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008559:Memantine / Q000627:therapeutic use; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D012601:Scopolamine; D012737:Sex Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018680:Cholinergic Antagonists; D018691:Excitatory Amino Acid Antagonists; D010936:Plant Extracts; D004008:Diclofenac; D012601:Scopolamine; D003474:Curcumin; D008559:Memantine