title: Magnesium sulfate ameliorates maternal and fetal inflammation in a rat model of maternal infection.
abstract: OBJECTIVE
  Magnesium sulfate is proposed to have neuroprotective effects in the offspring. We examined the effects of maternal magnesium sulfate administration on maternal and fetal inflammatory responses in a rat model of maternal infection.
  
  
  METHODS
  Pregnant rats were injected with saline, Gram-negative bacterial endotoxin lipopolysaccharide or lipopolysaccharide with magnesium sulfate (pre- and/or after lipopolysaccharide) to mimic infection. Maternal blood, amniotic fluid, fetal blood, and fetal brains were collected 4 hours after lipopolysaccharide and assayed for tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC. In addition, the effect of magnesium sulfate on cytokine production by an astrocytoma cell line was assessed.
  
  
  RESULTS
  Lipopolysaccharide administration induced tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC expression in maternal and fetal compartments. Maternal magnesium sulfate treatment significantly attenuated lipopolysaccharide-induced multiple proinflammatory mediator levels in maternal and fetal compartments.
  
  
  CONCLUSIONS
  Antenatal magnesium sulfate administration significantly ameliorated maternal, fetal, and gestational tissue-associated inflammatory responses in an experimental model of maternal infection.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY, USA.
authors.forename: Hima B
authors.initials: HB
authors.lastname: Tam Tam
authors.forename: Oonagh
authors.initials: O
authors.lastname: Dowling
authors.forename: Xiangying
authors.initials: X
authors.lastname: Xue
authors.forename: Dawnette
authors.initials: D
authors.lastname: Lewis
authors.forename: Burton
authors.initials: B
authors.lastname: Rochelson
authors.forename: Christine N
authors.initials: CN
authors.lastname: Metz
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism; D054360:Chemokine CXCL1 / Q000378:metabolism; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008278:Magnesium Sulfate / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018932:Chemokine CCL2; D054360:Chemokine CXCL1; D015850:Interleukin-6; D016209:Interleukin-8; D018696:Neuroprotective Agents; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D008278:Magnesium Sulfate