title: Effectiveness and cost-effectiveness of behavioural strategies in the prevention of cigarette smoking.
abstract: BACKGROUND
  The hazardous health effects of smoking and second hand smoke have been confirmed in numerous studies. For Germany, the mortality attributable to smoking is estimated at 110,000 to 140,000 deaths per year, associated with annual smoking-related costs of 17 to 21 billion euro. Because the majority of smokers initiate this habit early in life, behavioural preventive strategies usually tried to prevent the uptake of smoking among children and youths.
  
  
  OBJECTIVE
  The goal of this HTA is to summarise the current literature on behavioural strategies for smoking prevention and to evaluate their medical effectiveness/efficacy and cost-effectiveness as well as the ethical, social and legal implications of smoking prevention programs. In addition, this report aims to compare the effectiveness and efficacy of different intervention components and to evaluate the reliability of results in the German context.
  
  
  METHODS
  Relevant publications were identified by means of a structured search of databases accessed through the German Institute of Medical Documentation and Information (DIMDI). In addition a manual search of identified reference lists was conducted. The present report includes German and English literature published between August 2001 and August 2006 targeting youths up to 18 years old. The methodological quality of included studies was assessed according to pre-defined quality criteria, based on the criteria of evidence-based medicine.
  
  
  RESULTS
  Among 3,580 publications 37 medical studies met the inclusion criteria. Overall study quality was satisfactory but only half the studies reported smoking uptake as an outcome, while the remaining studies reported alternative outcome parameters. The follow-up duration varied between twelve and 120 months. Although overall effectiveness of prevention programs showed considerable heterogeneity, there was evidence for the long-term effectiveness of behavioural smoking prevention programs. However, the reduction in smoking rates was only moderate. Community and multisectorial interventions reported more conclusive evidence for reductions in smoking rates, while the evidence for school-based programs alone was inconclusive. Only one study from Germany fulfilled the methodological criteria and was included in this report. Three included economic studies focused on school-based interventions. Study results suggested, that the cost-effectiveness of school-based behavioural interventions is positive.
  
  
  CONCLUSIONS
  Behavioural preventive strategies were effective to delay or decrease uptake of smoking behaviour among children and youth. The effect size, however, was only moderate. Similar to previous research, there was no conclusive evidence for the long-term effectiveness of school-based interventions, whereas community and multisectorial interventions provided more conclusive evidence. However, sustainability of intervention effects has to be regarded with caution. In addition, there is evidence that findings from international studies can be adapted to the German situation and that intervention effectiveness is comparable. The available evidence regarding the cost-effectiveness of school-based interventions is not sufficient to draw reliable conclusions.
  
  
  CONCLUSIONS
  Behavioural preventive strategies can be effective in the prevention of smoking among children and youths. It seems advisable, though, to incorporate community strategies in addition to school-based strategies in order to improve their effectiveness. Future research should, amongst others, attempt to investigate the effectiveness of specific intervention components and the cost-effectiveness in methodologically high-quality studies.
authors.affiliation: Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
authors.forename: Falk
authors.initials: F
authors.lastname: Müller-Riemenschneider
authors.forename: Andrej
authors.initials: A
authors.lastname: Rasch
authors.forename: Angelina
authors.initials: A
authors.lastname: Bockelbrink
authors.forename: Christoph
authors.initials: C
authors.lastname: Vauth
authors.forename: Stefan N
authors.initials: SN
authors.lastname: Willich
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Greiner