title: Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.
abstract: Telomeres are present at the ends of all eukaryotic chromosomes. Human telomeres play an important role in critical processes underlying genome stability, cancer, and aging, and their importance was recognized via the award of the 2009 Nobel Prize in Physiology or Medicine. Chemistry has made vast and almost unparalleled contributions to telomere biology. This critical review highlights the contributions of chemistry in human telomeres and summarizes the significant development of human telomere biology. First, I provide an overview of the advances in understanding of the structures and functions of human telomeres. Second, I focus on the current efforts on developing various chemical approaches to targeting human telomeres and telomerase for the treatment of cancer. Third, studies on a newly discovered telomeric repeat-containing RNA are discussed in detail. Last, future challenges in the field are outlined, including perspectives of both chemistry and biology (412 references).
authors.affiliation: Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. xuyan@mkomi.rcast.u-tokyo.ac.jp
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D054856:G-Quadruplexes; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D009705:Nucleosides / Q000737:chemistry / Q000627:therapeutic use; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry / Q000627:therapeutic use; D019098:Telomerase / Q000737:chemistry* / Q000378:metabolism; D016615:Telomere / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009705:Nucleosides; D010455:Peptides; D054852:Small Molecule Libraries; D012313:RNA; D004247:DNA; D019098:Telomerase