title: Micronucleus index of rats treated with sodium nitrite can be amplified by sodium chloride.
abstract: OBJECTIVE
  The possible effect of sodium chloride as an amplifier of sodium nitrite co-carcinogenicity was assayed by in vivo experiments.
  
  
  METHODS
  18 male rats who matched for age and weight were tested for this experiment. They were at age of 8 weeks and weight of them was around 190 grams. They were exposed to the same environmental conditions, and they were divided into 3 groups: 1--The unexposed rats who were not under any special treatment (C group) 2--Rats who were treated twice with sodium nitrite in a dose of 5.18 mg/kg body weight, with an interval of 24 hours (N group). 3--Rats who were given sodium nitrite the same as second group, 24 hours after a single application of 1 ml of saturated sodium chloride solution (29 percent) (SN group). The bone marrow samplings were performed and the micronuclei index was evaluated in all three groups.
  
  
  RESULTS
  Sodium chloride combined with nitrite induced the significant elevation of micronuclei count in the SN group (p < 0.001). But sodium nitrite without sodium chloride did not have the same effect.
  
  
  CONCLUSIONS
  The data offers a possible amplification of sodium nitrite's co-carcinogenicity by sodium chloride in rats.
authors.affiliation: Department of Nutrition and Biochemistry, School of Public Health, Institute of Public Health Research, Tehran University of Medical Sciences, Pour Sina Ave, Tehran 14155-6447, Iran. fkoohdan@tums.ac.ir
authors.forename: Fariba
authors.initials: F
authors.lastname: Koohdani
authors.forename: Parvin
authors.initials: P
authors.lastname: Mehdipour
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects* / Q000235:genetics*; D004357:Drug Synergism; D005520:Food Preservatives / Q000494:pharmacology*; D008297:Male; D015162:Micronucleus Tests; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D012977:Sodium Nitrite / Q000494:pharmacology*
chemical_list: D005520:Food Preservatives; D012965:Sodium Chloride; D012977:Sodium Nitrite