title: Biochemical markers predicting pre-term delivery in symptomatic patients: phosphorylated insulin-like growth factor binding protein-1 and fetal fibronectin.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of the phosphorylated insulin-like growth factor-binding protein (phIGFBP-1) and of the fetal fibronectin test (fFN) in predicting pre-term delivery in symptomatic women.
  
  
  METHODS
  We included 210 symptomatic women at 24-34 weeks' gestation, who underwent the phIGFBP-1 and fFN test. We analyzed the prevalence of pre-term delivery in these patients within 7 days upon admission, before the 34th and the 37th weeks' gestation.
  
  
  RESULTS
  The 3.8% of women delivered within 7 days upon the admission, the 7.6% before 34 weeks and the 16.2% before 37 weeks' gestation. The phIGFBP-1 and fFN test had a high specificity and a high negative predictive value in predicting pre-term delivery within 7 days, before 34 and before 37 weeks' gestation. The logistic regression of phIGFBP-1 was statistically significant in predicting pre-term delivery with an odds ratio of 10.08 <34 weeks' gestation. The multivariate analysis showed that the phIGFBP test had a higher OR <34 weeks' gestation (p < 0.001) and that the two variables were independent and useful in combination to predict pre-term delivery (<37 weeks' gestation).
  
  
  CONCLUSIONS
  The phIGFBP-1 test may be better that the fFN test in predicting pre-term delivery before 34 weeks' gestation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Novara, "A. Avogadro" Via Solaroli 17, 28100 Novara, Italy. frriboni@tin.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Riboni
authors.forename: Anna
authors.initials: A
authors.lastname: Vitulo
authors.forename: Marinella
authors.initials: M
authors.lastname: Dell'avanzo
authors.forename: Mario
authors.initials: M
authors.lastname: Plebani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Battagliarin
authors.forename: Delia
authors.initials: D
authors.lastname: Paternoster
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D002582:Cervix Mucus / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D016015:Logistic Models; D007752:Obstetric Labor, Premature / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; C403421:FFN protein, human; D005353:Fibronectins; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1