title: Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.
abstract: Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β-cell failure. In addition to improving insulin resistance and preventing β-cell inflammatory damage, there is evidence of genetic association between diabetes and histone deacetylases (HDACs); and HDAC inhibitors (HDACi) promote β-cell development, proliferation, differentiation and function and positively affect late diabetic microvascular complications. Here we review this evidence and propose that there is a strong rationale for preclinical studies and clinical trials with the aim of testing the utility of HDACi as a novel therapy for diabetes.
authors.affiliation: Center for Medical Research Methodology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Dan P
authors.initials: DP
authors.lastname: Christensen
authors.forename: Mattias
authors.initials: M
authors.lastname: Dahllöf
authors.forename: Morten
authors.initials: M
authors.lastname: Lundh
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Rasmussen
authors.forename: Mette D
authors.initials: MD
authors.lastname: Nielsen
authors.forename: Nils
authors.initials: N
authors.lastname: Billestrup
authors.forename: Lars G
authors.initials: LG
authors.lastname: Grunnet
authors.forename: Thomas
authors.initials: T
authors.lastname: Mandrup-Poulsen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000201:enzymology* / Q000378:metabolism*; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D056572:Histone Deacetylase Inhibitors; D053583:Interleukin-1beta; D006655:Histone Deacetylases