title: Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.
abstract: 5-Hydroxytryptamine(2A) (5-HT(2A)) serotonin receptors are important pharmacological targets for a large number of central nervous system and peripheral serotonergic medications. In this review article I summarize work mainly from my lab regarding serotonin receptor anatomy, pharmacology, signaling and regulation. I highlight the role of serotonin receptor interacting proteins and the emerging paradigm of G-protein coupled receptor functional selectivity.
authors.affiliation: Department of Pharmacology, Program in Neurosciences, Lineberger Cancer Center, NIMH Psychoactive Drug Screening Program, and Division of Medicinal Chemistry and Natural Products, Room 4072, Genetic Medicine Building, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC 27514, USA. bryan_roth@med.unc.edu
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
mesh_terms: D000818:Animals; D006801:Humans; D009419:Nerve Tissue Proteins / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D054730:Protein Interaction Domains and Motifs; D044402:Receptor, Serotonin, 5-HT2A / Q000737:chemistry / Q000378:metabolism*; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D009419:Nerve Tissue Proteins; D044402:Receptor, Serotonin, 5-HT2A; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists