title: Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Aβ aggregation in SH-SY5Y cells.
abstract: Alzheimer's disease (AD) is a common form of neurodegenerative disease. Mounting evidence suggests that metal ions play a key role in the aggregation of amyloid β peptide (Aβ), which acts as a factor or cofactor in the etiopathogenesis of AD. Therefore, inhibition of Aβ aggregation emerges as a potential approach for the treatment of AD. We have found that baicalin can interact with copper directly and inhibits Aβ1-42 aggregation. In addition, baicalin protects SH-SY5Y cells from oxidative injuries induced by Aβ1-42 aggregation through decreasing H(2)O(2) production that is normally formed as a deleterious by-product of beta amyloid aggregation and the formation of plaques. Taken together, these data indicate that baicalin may be a potential agent to inhibit Aβ aggregation and thereby delay, mitigate or modify the progression of neurodegenerative diseases such as AD.
authors.affiliation: Research Center of Medicinal Chemistry and Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yin
authors.forename: Jianhui
authors.initials: J
authors.lastname: Liu
authors.forename: Xiuhong
authors.initials: X
authors.lastname: Ji
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Wang
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Zidichouski
authors.forename: Junzeng
authors.initials: J
authors.lastname: Zhang
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism* / Q000494:pharmacology / Q000648:ultrastructure; D000975:Antioxidants / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003300:Copper / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D044950:Flavanones / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D009447:Neuroblastoma / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D010446:Peptide Fragments / Q000378:metabolism* / Q000494:pharmacology / Q000648:ultrastructure; D019800:Phenol / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D031364:Scutellaria baicalensis; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D044950:Flavanones; D010446:Peptide Fragments; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; C075222:amyloid beta-protein (1-42); D019800:Phenol; C006680:baicalein; D003300:Copper; D006861:Hydrogen Peroxide