title: Functionalisation of aldehydes via aerobic hydroacylation of azodicarboxylates 'on' water.
abstract: Herein we report the functionalisation of aldehydes via hydroacylation of azodicarboxylates. A range of functionalised aldehydes are employed as the limiting reagent including chiral non-racemic aldehydes bearing α-stereocentres which are functionalised giving access to enantiomerically pure products. The resultant hydrazides can be employed as acyl donors in the synthesis of amides.
authors.affiliation: Department of Chemistry, University College London, London, WC1H 0AJ, UK.
authors.forename: Vijay
authors.initials: V
authors.lastname: Chudasama
authors.forename: Jenna M
authors.initials: JM
authors.lastname: Ahern
authors.forename: Dipti V
authors.initials: DV
authors.lastname: Dhokia
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Fitzmaurice
authors.forename: Stephen
authors.initials: S
authors.lastname: Caddick
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000577:Amides; D002264:Carboxylic Acids; D014867:Water