title: [Hemolytic and uremic syndrome and maternal-fetal Escherichia coli K1 infection].
abstract: Hemolytic uremic syndrome (HUS) is primarily a disease of infancy and early childhood. In its classic form, it is preceded by a prodrome of Escherichia coli-mediated bloody mucoid diarrhea. Typical HUS is commonly related to an infection by shiga-toxin producing E. coli. Stool cultures may detect this bacteria or its toxin, and PCRs can detect the shiga-toxin virulence genes. Atypical cases of HUS are mainly related to abnormalities of the alternative complement pathway and mutations of H, I, or B factors. Some atypical cases of HUS may also be related to von Willebrand factor or vitamin B12 metabolism abnormalities. A number of HUS cases related to invasive pneumococcal infections (pneumonia or meningitis) have been reported. We report a case of HUS associated with a bacterial E. coli K1 infection in a newborn baby, with a good clinical outcome: there was no need for dialysis and normal renal function was quickly regained. The workup did not favor a toxinic origin or an abnormality on the alternative complement pathway.
authors.affiliation: Service de pédiatrie, hôpital Femme-Enfant-hématologie, CHU Côte-de-Nacre, avenue Côte-de-Nacre, 14033 Caen cedex 9, France. magali.flandrois@laposte.net
authors.forename: M
authors.initials: M
authors.lastname: Flandrois
authors.forename: A
authors.initials: A
authors.lastname: Bessière
authors.forename: S
authors.initials: S
authors.lastname: Vieira-Roth
authors.forename: M
authors.initials: M
authors.lastname: Vergnaud
authors.forename: V
authors.initials: V
authors.lastname: Frémeaux-Bacchi
authors.forename: P
authors.initials: P
authors.lastname: Eckart
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious
chemical_list: D000900:Anti-Bacterial Agents