title: Trends in inflammatory biomarkers during atrial fibrillation ablation across different catheter ablation strategies.
abstract: BACKGROUND
  Chest pain after atrial fibrillation (AF) ablations is a common complaint with a wide differential diagnosis including coronary events. Elevation of troponins (Trop I) has been shown with radio-frequency (RF) ablation for atrial fibrillation. New devices including cryoballoon and multipolar ablation catheters have been introduced as alternative methods. We aim to compare cardiac injury following AF ablations according to different ablation technologies.
  
  
  METHODS
  In consecutive patients undergoing AF ablations with RF ablation, cryoballoon or multipolar ablation catheter (PVAC), Trop I, creatine kinase (CK) and CRP were analyzed immediately prior to and 24h following completion of ablation. Coronary events and symptoms and serial ECGs post procedure were evaluated.
  
  
  RESULTS
  A total of 243 patients were included, 18.5% of them females. The mean age was 63 ± 11 years old. Baseline Trop I, CK and CRP levels were within normal range in all patients. After RF ablation Trop I, CK and CRP levels were elevated in 100%, 20% and 91% of patients respectively (Trop I 3.55 pg/ml [range: 0.60-24.01 pg/ml], CK 147 U/l [range: 56-380 U/l] and CRP 2.15 mg/dl [range: 0.28-20.98 mg/dl]). All post-procedure Trop I levels were above the range of myocardial infarction (>0.15 ng/ml). After cryoballoon ablation, Trop I and CK levels were significantly higher than after RF or PVAC ablation (p<0.001). No ischemic ECG changes were documented.
  
  
  CONCLUSIONS
  Trop I elevations are not specific for ischemia in the setting of chest pain after AF ablation. Cryoballoon ablation resulted in a higher amount of cardiac injury.
authors.affiliation: Division of Cardiology, Klinikum Coburg, Germany. mschmidtco@arcor.de
authors.forename: Martin
authors.initials: M
authors.lastname: Schmidt
authors.forename: Harald
authors.initials: H
authors.lastname: Marschang
authors.forename: Sarah
authors.initials: S
authors.lastname: Clifford
authors.forename: Rittger
authors.initials: R
authors.lastname: Harald
authors.forename: Ritscher
authors.initials: R
authors.lastname: Guido
authors.forename: Turschner
authors.initials: T
authors.lastname: Oliver
authors.forename: Brachmann
authors.initials: B
authors.lastname: Johannes
authors.forename: Marcos
authors.initials: M
authors.lastname: Daccarett
mesh_terms: D001281:Atrial Fibrillation / Q000097:blood* / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D017115:Catheter Ablation / Q000379:methods*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I; D002097:C-Reactive Protein; D003402:Creatine Kinase