title: Protein kinase C regulation: C1 meets C-tail.
abstract: In a recent issue of Cell, Leonard et al. (2011) describe the structure of PKCβII, an AGC kinase, revealing an unanticipated intramolecular autoinhibitory interaction between its C-terminal tail and the diacylglycerol and phorbol ester binding site of its C1b domain.
authors.affiliation: Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. marcelog@upenn.edu
authors.forename: Marcelo G
authors.initials: MG
authors.lastname: Kazanietz
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lemmon