title: Therapeutic applications of compounds in the Magnolia family.
abstract: The bark and/or seed cones of the Magnolia tree have been used in traditional herbal medicines in Korea, China and Japan. Bioactive ingredients such as magnolol, honokiol, 4-O-methylhonokiol and obovatol have received great attention, judging by the large number of investigators who have studied their pharmacological effects for the treatment of various diseases. Recently, many investigators reported the anti-cancer, anti-stress, anti-anxiety, anti-depressant, anti-oxidant, anti-inflammatory and hepatoprotective effects as well as toxicities and pharmacokinetics data, however, the mechanisms underlying these pharmacological activities are not clear. The aim of this study was to review a variety of experimental and clinical reports and, describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of Magnolia and/or its constituents.
authors.affiliation: College of Pharmacy and Medical Research Center, Chungbuk National University, 12 Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk 361-763, Republic of Korea.
authors.forename: Young-Jung
authors.initials: YJ
authors.lastname: Lee
authors.forename: Yoot Mo
authors.initials: YM
authors.lastname: Lee
authors.forename: Chong-Kil
authors.initials: CK
authors.lastname: Lee
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Jung
authors.forename: Sang Bae
authors.initials: SB
authors.lastname: Han
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002681:China; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007564:Japan; D007723:Korea; D031566:Magnolia / Q000737:chemistry*; D008518:Medicine, East Asian Traditional / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy*; D009422:Nervous System Diseases / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts