title: Targeting bacterial biofilms: design of a terpenoid-like library as non-toxic anti-biofilm compounds.
abstract: A new class of anti-biofilm compounds possessing 1,4-disubstituted-(1H)-1,2,3-triazolic cores was designed. Their efficient synthesis was performed by means of click chemistry through 1,3-dipolar cycloadditions. Two compounds were found to act as specific anti-biofilm agents against a gram negative species.
authors.affiliation: Laboratoire MAPIEM, EA 4323, UFR Sciences et Techniques, Université du Sud Toulon-Var, La Garde, France.
authors.forename: Cheikh
authors.initials: C
authors.lastname: Sall
authors.forename: Linda
authors.initials: L
authors.lastname: Dombrowsky
authors.forename: Olivier
authors.initials: O
authors.lastname: Bottzeck
authors.forename: Annie
authors.initials: A
authors.lastname: Praud-Tabariès
authors.forename: Yves
authors.initials: Y
authors.lastname: Blache
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects*; D016503:Drug Delivery Systems; D015195:Drug Design; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D013729:Terpenes; D014230:Triazoles