title: Elongator: an ancestral complex driving transcription and migration through protein acetylation.
abstract: Elongator is an evolutionary highly conserved complex. At least two of its cellular functions rely on the intrinsic lysine acetyl-transferase activity of the elongator complex. Its two known substrates--histone H3 and α-tubulin--reflect the different roles of elongator in the cytosol and the nucleus. A picture seems to emerge in which nuclear elongator could regulate the transcriptional elongation of a subset of stress-inducible genes through acetylation of histone H3 in the promoter-distal gene body. In the cytosol, elongator-mediated acetylation of α-tubulin contributes to intracellular trafficking and cell migration. Defects in both functions of elongator have been implicated in neurodegenerative disorders.
authors.affiliation: Chromatin and Cell Fate Group, Institute for Predictive and Personalized Medicine of Cancer (IMPPC), 08916 Badalona, Spain.
authors.forename: Catherine
authors.initials: C
authors.lastname: Creppe
authors.forename: Marcus
authors.initials: M
authors.lastname: Buschbeck
mesh_terms: D000107:Acetylation; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D014404:Tubulin / Q000378:metabolism
chemical_list: D006657:Histones; D009419:Nerve Tissue Proteins; D014404:Tubulin; D051548:Histone Acetyltransferases