title: [Pharmacokinetic study of a new chewing gum dextromethorphan delivery system].
abstract: OBJECTIVE
  To establish an high-performance liquid chromatography (HPLC)-based method for analysis of the pharmacokinetics and relative bioavailability of dextromethorphan chewing gum tablets in rabbits.
  
  
  METHODS
  The pharmacokinetic parameters and the relative bioavailability of dextromethorphan chewing gum preparation in rabbits were compared with those of the commercially available chewing dextromethorphan tablets using 3P97 software.
  
  
  RESULTS
  Pharmacokinetic analysis of the new dextromethorphan chewing gum tablets showed a AUC of 488.76 ∓ 175.00 ng.ml(-1).h, C(max) of 95.45 ∓ 17.53 ng/ml, and t(max) of 1.83 ∓ 0.57 h as compared with the corresponding parameters of 370.13 ∓ 90.56 ng.ml(-1).h, 174.00 ∓ 47.88 ng.ml, and 1.04 ∓ 0.14 h for the commercially available chewing tablets. The relative bioavailability of the new chewing gum medicine system was (140.73 ∓ 65.91)%.
  
  
  CONCLUSIONS
  The new dextromethorphan chewing gum preparation shows an increased AUC((0→)), decreased C(max), and prolonged t(max) in comparison with the commercially available chewing tablets, with also a greatly enhanced relative bioavailability.
authors.affiliation: Chongqing Key Laboratory of Biochemical and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Qun-you
authors.initials: QY
authors.lastname: Tan
authors.forename: Bi-lin
authors.initials: BL
authors.lastname: Liu
authors.forename: Mei-ling
authors.initials: ML
authors.lastname: Xu
authors.forename: Chun-jing
authors.initials: CJ
authors.lastname: Zhao
authors.forename: Jing-qing
authors.initials: JQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001682:Biological Availability; D002638:Chewing Gum; D002851:Chromatography, High Pressure Liquid; D003915:Dextromethorphan / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D011817:Rabbits
chemical_list: D002638:Chewing Gum; D003915:Dextromethorphan