title: Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy.
abstract: To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.
authors.affiliation: Ribeirão Preto School of Medicine, University of São Paulo, 14049-900 Ribeirão Preto, Brazil. priscilalima@usp.br
authors.forename: Priscila
authors.initials: P
authors.lastname: Freitas-Lima
authors.forename: Veriano
authors.initials: V
authors.lastname: Alexandre
authors.forename: Leonardo Regis Leira
authors.initials: LR
authors.lastname: Pereira
authors.forename: Fausto
authors.initials: F
authors.lastname: Feletti
authors.forename: Emilio
authors.initials: E
authors.lastname: Perucca
authors.forename: Americo Ceiki
authors.initials: AC
authors.lastname: Sakamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019540:Area Under Curve; D016022:Case-Control Studies; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D008875:Middle Aged; D010889:Piracetam / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D013997:Time Factors; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam