title: A new coumestan with immunosuppressive activities from Flemingia philippinensis.
abstract: A new coumestan, 1,3,9-trihydroxy-8-methoxycoumestan, named flemicoumestan A 1 together with nine isoflavone-related compounds were isolated from the ethyl acetate extract of the roots of Flemingia philippinensis. Their structures were elucidated and confirmed by spectroscopic methods and literature data. Compounds 3 and 4 showed strong lymphocyte proliferation inhibitory activity with an IC(50) value of 1.04-2.76 μM, and the low cytotoxicity with the CC(50) value of 71.01 and 56.36 μM, respectively.
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Xueyang
authors.initials: X
authors.lastname: Deng
authors.forename: Lixia
authors.initials: L
authors.lastname: Zhang
authors.forename: Pan
authors.initials: P
authors.lastname: Shu
authors.forename: Minjian
authors.initials: M
authors.lastname: Qin
mesh_terms: D000818:Animals; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure
chemical_list: D003374:Coumarins; D007166:Immunosuppressive Agents; C560390:flemicoumestan A; C505898:coumestan