title: Do not assume symptoms indicate failure of anti-tumor necrosis factor therapy in Crohn's disease.
abstract: It is a challenge to monitor patients with Crohn's disease who remain symptomatic despite anti-tumor necrosis factor therapy. Clinicians must use a systematic approach for each patient and obtain objective evidence about disease activity and response to therapy. Alternate etiologies for symptoms should be sought and treated, if found. Active Crohn's disease despite therapy requires reassessment and adjustments to management plans.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Bruining
authors.forename: William J
authors.initials: WJ
authors.lastname: Sandborn
mesh_terms: D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
chemical_list: D007155:Immunologic Factors; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha