title: Oncogenic osteomalacia of the cervical spine: a rare case of curative resection and reconstruction.
abstract: Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome, with only 100 reported cases in the literature. The majority of OO-associated mesenchymal tumors are due to a lesion called phosphaturic mesenchymal tumor, mixed connective tissue (PMTMCT) variant. There have been only 6 reported cases of OO of the spine. With this paper the authors present a case of OO of the cervical spine in a patient who initially presented with multiple pathological fractures of unknown cause, and who eventually underwent staged C-5 spondylectomy followed by circumferential stabilization. Resection of the cervical lesion led to resolution of his hypophosphatemia and prevention of any further pathological fractures. The authors describe a rare cervical neoplasm, its treatment, and review the literature on this rare bony pathological entity.
authors.affiliation: Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 675 North St. Clair Street, Chicago, Illinois 60611, USA.
authors.forename: Murtaza
authors.initials: M
authors.lastname: Akhter
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Sugrue
authors.forename: Rick
authors.initials: R
authors.lastname: Bains
authors.forename: Yevgeniy A
authors.initials: YA
authors.lastname: Khavkin
mesh_terms: D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000000981:diagnostic imaging / Q000601:surgery; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging / Q000601:surgery*; D011859:Radiography; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome