title: Side effects of chemotherapy in musculoskeletal oncology.
abstract: With recent advances in medical and orthopedic oncology, radiation therapy and single- or multiple-agent perioperative chemotherapy are currently applied as an essential part of the multidisciplinary treatment to improve disease-free and overall survival of patients with primary and metastatic bone and soft tissue tumors. However, these treatments have led to unwanted complications. A better understanding of the effects of various antineoplastic agents on bone, soft tissue, and organs may provide the basis for the more efficacious use of antiproliferative drugs when fracture healing or allograft incorporation is required. This knowledge may also provide a rationale for concurrent treatment with drugs that protect against or compensate for adverse effects in osseous repair resulting from chemotherapy.
authors.affiliation: Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna, Italy.
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Mavrogenis
authors.forename: Panayiotis J
authors.initials: PJ
authors.lastname: Papagelopoulos
authors.forename: Matteo
authors.initials: M
authors.lastname: Romantini
authors.forename: Andrea
authors.initials: A
authors.lastname: Angelini
authors.forename: Pietro
authors.initials: P
authors.lastname: Ruggieri
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy*; D016025:Bone Transplantation; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects; D003131:Combined Modality Therapy; D017102:Fracture Healing / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000187:drug effects; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*; D013116:Spinal Cord / Q000187:drug effects; D014184:Transplantation, Homologous; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents