title: Study on modified shengmai yin injection for prevention and treatment of brain impairment in endotoxin shock rats.
abstract: OBJECTIVE
  To examine the effects of modified Shenmai Yin on invigorating vital energy, promoting blood flow, and protection against neural impairment in an endotoxin-induced shock rat model.
  
  
  METHODS
  Ninety-six SD rats were randomly divided into four groups: sham operation (saline 20 ml/kg), shock model (lipopolysaccharide, LPS, 8 mg/kg), Reformed Shengmai Yin (Pulse-activating Decoction) (LPS 8 mg/kg + reformed Shengmai Yin Injection 10 ml/kg), and dexamethasone (LPS 8 mg/kg + dexamethasone 5 mg/kg) groups. Each group was subdivided into 1 h, 2 h, 3 h, and 6 h time points for observation. The carotid artery was separated and connected with a biological functional system to monitor mean arterial pressure (MAP). Brain water levels, malonaldehyde (MDA) content, and superoxide dismutase (SOD) activity were also determined.
  
  
  RESULTS
  In the shock model group, MAP was progressively decreased after injection of LPS, brain water and MDA contents were increased, brain SOD activity was decreased, and capillary vessel edema in brain tissue was also observed. All these parameters were improved significantly in both treatment groups, although the effects were more marked with Shengmai Yin than with dexamethasone.
  
  
  CONCLUSIONS
  Modified Shengmai Yin exhibits strong anti-shock and neuroprotective effects against Endotoxin-induced shock.
authors.affiliation: College of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. zyz100102@126.com
authors.forename: Yu-Zhong
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wu
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Ren
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Jia
authors.forename: Yin-Zhu
authors.initials: YZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012772:Shock, Septic / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D008315:Malondialdehyde