title: A red cheek as first clinical sign of a sebaceous lymphadenocarcinoma of the parotid gland with lymphangiosis carcinomatosa and lymph node metastases.
abstract: Sebaceous lymphadenoma is a rare benign neoplasm presenting predominantly in the parotid gland or in periparotid lymph nodes. It rarely transforms into a malignant tumor. We present a sebaceous lymphadenoma with an unusual clinical presentation with a malignant component, infiltration of lymph nodes, and lymphangiosis carcinomatosa. Sebaceous lymphadenoma usually presents as a well-circumscribed, painless, infraauricular mass. In our 87-years-old male patient, the clinical presentation was confluent reddish livid plaques at the left cheek and the left neck. In addition, cervical lymph node metastases were suspected. After skin biopsy, the tumor was excised by parotidectomy, skin excision, and neck dissection followed by a postoperative radiotherapy. To our knowledge, this is the sixth reported case of sebaceous lymphadenocarcinoma and the first case presenting with cervical lymph node metastases and dermatological symptoms revealing lymphangiosis carcinomatosa.
authors.affiliation: Department of Dermatology, University of Würzburg, Würzburg, Germany.
authors.forename: Karoline
authors.initials: K
authors.lastname: Claudius
authors.forename: Christian
authors.initials: C
authors.lastname: Ginzkey
authors.forename: Stefan
authors.initials: S
authors.lastname: Gattenlöhner
authors.forename: Justus
authors.initials: J
authors.lastname: Müller
authors.forename: Philipp
authors.initials: P
authors.lastname: Demmer
authors.forename: Eva-Bettina
authors.initials: EB
authors.lastname: Bröcker
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000235:Adenolymphoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002610:Cheek; D004890:Erythema / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D018192:Lymphangioleiomyomatosis / Q000150:complications / Q000175:diagnosis*; D008207:Lymphatic Metastasis; D008297:Male; D037981:Neck Dissection; D010306:Parotid Gland / Q000601:surgery; D010307:Parotid Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012626:Sebaceous Gland Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor