title: Recombinant Microcystis viridis lectin as a potential anticancer agent.
abstract: MVL (Microcystis viridis lectin), a glycoprotein originally isolated from freshwater blue-green algae Microcystis viridis, has been reported to have potent anti-HIV activity. However, the objective of this study was to evaluate the anticancer activity of recombinant MVL (R-MVL). MTT assay was used to evaluate the in vitro anticancer activity of R-MVL, and the results show that the IC50 for HT-29, HepG2, SGC-7901 and SK-OV-3 were 40.20, 42.67, 49.87, and 53.40 microg/ml, respectively. Our data, for the first time, demonstrated that R-MVL exhibits potential anticancer activity, and open new therapeutic possibilities for the use of R-MVL as anti-cancer agent.
authors.affiliation: College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Li
authors.forename: Xuewu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D006801:Humans; D037102:Lectins / Q000235:genetics / Q000494:pharmacology*; D046931:Microcystis / Q000737:chemistry* / Q000235:genetics
chemical_list: D037102:Lectins