title: The desensitizing efficacy of a novel stannous-containing sodium fluoride dentifrice: an 8-week randomized and controlled clinical trial.
abstract: OBJECTIVE
  To assess the efficacy of a novel stannous-containing dentifrice in the reduction of dentin hypersensitivity when compared to a marketed positive control dentifrice.
  
  
  METHODS
  An 8-week, single-center, randomized, parallel group, two-treatment, double-blind clinical study was conducted in a generally healthy adult population with moderate thermal and tactile dentin hypersensitivity. A total of 60 adults were enrolled into the study. Participants were stratified at baseline by age, gender, and cold air sensitivity scores, and randomly assigned to either an experimental stannous-containing sodium fluoride dentifrice or a marketed potassium nitrate positive control. Brushing was supervised on site after baseline and Week 4 examinations. All other product usage was unsupervised. Subjects brushed 2 minutes twice daily. At baseline, Week 4 and Week 8, efficacy outcomes were assessed for tactile sensitivity via the Yeaple Probe, and for thermal sensitivity with air-blast/SchiffAir Index.
  
  
  RESULTS
  Fifty-eight subjects completed all evaluations. Both the experimental stannous-containing and positive control dentifrices provided significant (P< 0.05) reductions in both tactile and thermal dentin hypersensitivity compared to baseline at both Weeks 4 and 8. There were no significant differences in Yeaple Probe or Schiff Air Index results between the dentifrices with either efficacy measurement at Week 4 and Week 8 (P > or = 0.5375).
authors.affiliation: School of Stomatology, Fourth Military Medical University Xian, China.
authors.forename: Long Xing
authors.initials: LX
authors.lastname: Ni
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Alice
authors.initials: A
authors.lastname: Chang
authors.forename: Lily
authors.initials: L
authors.lastname: Sun
mesh_terms: D000328:Adult; D002327:Cariostatic Agents / Q000627:therapeutic use; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D010147:Pain Measurement; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D017680:Potassium Compounds / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D017971:Tin Compounds / Q000627:therapeutic use; D014002:Tin Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; C510825:Crest Pro-Health Dentifrice; D003802:Dentifrices; D057133:Dentin Desensitizing Agents; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; D017971:Tin Compounds; D014002:Tin Fluorides; C023599:stannous chloride; D012969:Sodium Fluoride; C023844:potassium nitrate