title: Hydrogen sulfide in gastrointestinal and liver physiopathology.
abstract: Hydrogen sulfide (H(2)S) is a gas that can be formed by the action of two enzymes, cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS). H(2)S has been known for hundreds of years for its poisoning effect, however the idea that H(2)S is not only a poison, but can exert a physiological role in mammalian organisms, originates from the evidence that this gaseous mediator is produced endogenously. In addition to H(2)S synthesis by gastrointestinal tissue, the intestinal mucosa, particularly in the large intestine, is regularly exposed to high concentrations of H(2)S that are generated by some species of bacteria and through the reduction of unabsorbed intestinal inorganic sulphate. This review reports on the effects of H(2)S in the gastrointestinal tract and liver and provides information on the therapeutic applications of H(2)S-donating drugs.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Università Degli Studi di Perugia, Policlinico Monteluce, Via E. dal Pozzo, 06100 Perugia, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Cipriani
authors.forename: Andrea
authors.initials: A
authors.lastname: Mencarelli
mesh_terms: D000818:Animals; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000503:physiopathology*; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000503:physiopathology*
chemical_list: D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide