title: Effect of high-dose estrogen in luteal phase support on live birth rates after assisted reproduction treatment cycles.
abstract: OBJECTIVE
  The role of estrogen administration for luteal phase support (LPS) after assisted reproductive technologies treatment is not well established. While most studies report ineffectiveness of doses up to 4 mg/day, a small randomized, controlled trial suggested improved clinical outcome with higher dosage of 6 mg/day. The present pilot trial assessed effectiveness of 6 mg/day estrogen in addition to progesterone administration for LPS.
  
  
  METHODS
  Randomized, controlled trial. Sixty women undergoing assisted reproduction treatment were randomly allocated to receive progesterone vaginal gel with or without 6 mg/day 17beta-estradiol (E2) orally starting from the embryo transfer day.
  
  
  RESULTS
  Embryo implantation rates were 33.33% and 28.9% in the control and E2 groups, respectively (p = 0.64). There were 11 (36.7%) live births in the control group, while there were 10 (33.3%) live births in the E2 group (p = 0.79).
  
  
  CONCLUSIONS
  Our results do not suggest a beneficial effect of orally administered estrogen as adjuncts to progesterone for luteal support when administered to all patients in an unselective manner, even in a dose of 6 mg/day.
authors.affiliation: Assisted Reproduction Unit, American Hospital of Istanbul, Turkish Republic. barisata@hotmail.com
authors.forename: Baris
authors.initials: B
authors.lastname: Ata
authors.forename: Mert
authors.initials: M
authors.lastname: Kucuk
authors.forename: Ayse
authors.initials: A
authors.lastname: Seyhan
authors.forename: Bulent
authors.initials: B
authors.lastname: Urman
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D004958:Estradiol / Q000008:administration & dosage*; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D050498:Live Birth; D008183:Luteal Phase; D010865:Pilot Projects; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: C400424:Crinone; D004967:Estrogens; D011374:Progesterone; D004958:Estradiol