title: Dermatofibrosarcoma protuberans with fibrosarcomatous transformation of the head and neck.
abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm associated with a high cure rate. We present a case of aggressive DFSP with fibrosarcomatous areas in the head and neck. A 28-year-old Mediterranean female presented with a 45-day history of rapidly growing cutaneous lesion of the face. Surgical biopsy confirmed the diagnosis of DFSP. Subsequently, the patient underwent wide local surgical resection, followed by reconstruction. Histopathology report revealed fibrosarcomatous transformation and the patient underwent adjuvant radiotherapy. The patient continues to be disease free at the 35-month follow-up.Although DFSP behave as non-aggressive malignancy, surgery with complete removal of the affected area is the intervention of choice. Moreover, adjuvant treatment and follow-up of the patient is essential in order to prevent recurrence.
authors.affiliation: Otorhinolaryngology, Head and Neck Surgery Department, AHEPA University Hospital, Thessaloniki, Greece. nikos.angouridakis@gmail.com
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Angouridakis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kafas
authors.forename: Waseem
authors.initials: W
authors.lastname: Jerjes
authors.forename: Stefanos
authors.initials: S
authors.lastname: Triaridis
authors.forename: Tahwinder
authors.initials: T
authors.lastname: Upile
authors.forename: Georgios
authors.initials: G
authors.lastname: Karkavelas
authors.forename: Angelos
authors.initials: A
authors.lastname: Nikolaou
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D018223:Dermatofibrosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery