title: Identification of blood microRNAs associated to Parkinsonĭs disease.
abstract: The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers.
authors.affiliation: Neurology Section, Movement Disorders Unit, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-00 Porto Alegre, RS, Brazil.
authors.forename: Regina
authors.initials: R
authors.lastname: Margis
authors.forename: Rogério
authors.initials: R
authors.lastname: Margis
authors.forename: Carlos R M
authors.initials: CR
authors.lastname: Rieder
mesh_terms: D000368:Aged; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000235:genetics*
chemical_list: D035683:MicroRNAs