title: Fabrication of low-crystalline carbonate apatite foam bone replacement based on phase transformation of calcite foam.
abstract: Carbonate apatite (CO(3)Ap) foam may be an ideal bone substitute as it is sidelined to cancellous bone with respect to its chemical composition and structure. However, CO(3)Ap foam fabricated using α-tricalcium phosphate foam showed limited mechanical strength. In the present study, feasibility of the fabrication of calcite which could be a precursor of CO(3)Ap was studied. Calcite foam was successfully fabricated by the so-called "ceramic foam" method using calcium hydroxide coated polyurethane foam under CO(2)+O(2) atmosphere. Then the calcite foam was immersed in Na(2)HPO(4) aqueous solution for phase transformation based on dissolution-precipitation reaction. When CaO-free calcite foam was immersed in Na(2)HPO(4) solution, low-crystalline CO(3)Ap foam with 93-96% porosity and fully interconnected porous structure was fabricated. The compressive strength of the foam was 25.6 ± 6 kPa. In light of these results, we concluded that the properties of the precursor foam were key factors for the fabrication of CO(3)Ap foams.
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. maruchan@dent.kyushu-u.ac.jp
authors.forename: Michito
authors.initials: M
authors.lastname: Maruta
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsuya
authors.forename: Seiji
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D001031:Apatites / Q000138:chemical synthesis* / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D002119:Calcium Carbonate / Q000138:chemical synthesis* / Q000737:chemistry; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry; D019245:Compressive Strength; D003460:Crystallization; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry; D016062:Porosity; D013314:Stress, Mechanical
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D011140:Polyurethanes; C030782:carboapatite; D002119:Calcium Carbonate