title: A case of periostitis secondary to voriconazole therapy in a heart transplant recipient.
abstract: A 66-year-old man with a history of heart transplant for idiopathic dilated cardiomyopathy presented with progressive bone pain and myalgias. He has been on voriconazole for a pulmonary Aspergillus infection for 9 months. He had an elevated alkaline phosphatase of 280. There is no history of rheumatologic disease. Drug-induced periostitis has recently been reported in patients on long-term voriconazole therapy after lung transplantation for prophylaxis and treatment of Aspergillus infection. This case demonstrates the same phenomenon in a heart transplant patient. This patient's symptoms improved after discontinuation of voriconazole.
authors.affiliation: Department of Radiology, University of Wisconsin Hospital and Clinics, Madison, WI, USA. swise@uwhealth.org
authors.forename: Steven M
authors.initials: SM
authors.lastname: Wise
authors.forename: Michael A
authors.initials: MA
authors.lastname: Wilson
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000009:adverse effects*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D010522:Periostitis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011743:Pyrimidines / Q000009:adverse effects*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000009:adverse effects*; D065819:Voriconazole; D051598:Whole Body Imaging
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole