title: Epigenetic impacts on neurodevelopment: pathophysiological mechanisms and genetic modes of action.
abstract: Disruptions of genes that are involved in epigenetic functions are known to be causative for several mental retardation/intellectual disability (MR/ID) syndromes. Recent work has highlighted genes with epigenetic functions as being implicated in autism spectrum disorders (ASDs) and schizophrenia (SCZ). The gene-environment interaction is an important factor of pathogenicity for these complex disorders. Epigenetic modifications offer a mechanism by which we can explain how the environment interacts with, and is able to dynamically regulate, the genome. This review aims to provide an overview of the role of epigenetic deregulation in the etiopathology for neurodevelopment disease.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada. farahz@interchange.ubc.ca
authors.forename: Farah R
authors.initials: FR
authors.lastname: Zahir
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Brown
mesh_terms: D002490:Central Nervous System / Q000254:growth & development; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics; D044127:Epigenesis, Genetic; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics