title: Synthesis and diversification of 1,2,3-triazole-fused 1,4-benzodiazepine scaffolds.
abstract: A substituted heterocyclic scaffold comprising a 1,4-benzodiazepine fused with a 1,2,3-triazole ring has been synthesized and diversified via a variety of refunctionalizations. The strategy features the rapid assembly of the scaffold by combining 3-4 reactants in an efficient multicomponent assembly process, followed by an intramolecular Huisgen cycloaddition.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Donald
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014230:Triazoles; D001569:Benzodiazepines; C468549:Bz-423