title: Prospective validation study of a predictive score for operability of recurrent ovarian cancer: the Multicenter Intergroup Study DESKTOP II. A project of the AGO Kommission OVAR, AGO Study Group, NOGGO, AGO-Austria, and MITO.
abstract: OBJECTIVE
  The DESKTOP I trial proposed a score for the prediction of complete cytoreduction in recurrent ovarian cancer. Resectability was assumed if 3 factors were present: (1) complete resection at first surgery, (2) good performance status, and (3) absence of ascites. The DESKTOP II trial was planned to verify this hypothesis prospectively in a multicenter setting.
  
  
  METHODS
  Participating centers prospectively enrolled all consecutive patients with platinum-sensitive first or second relapse. The score was applied to all patients, but centers were free to decide on therapy. All further therapies were documented, and the outcome of patients was analyzed. A 75% complete resection rate in 110 prospectively classified patients had to be achieved to confirm a positive predictive value of 2 or higher of 3 with 95% probability.
  
  
  RESULTS
  A total of 516 patients were screened within 19 months; of these, 261 patients (51%) were classified as score positive, and 129 patients with a positive score and first relapse were operated on. The rate of complete resection was 76%, thus confirming the validity of this score regarding positive prediction of complete resectability in 2 or more of 3 patients. Complication rates were moderate including second operations in 11% and perioperative mortality in 0.8%.
  
  
  CONCLUSIONS
  This score is the first prospectively validated instrument to positively predict surgical outcome in recurrent ovarian cancer. It can aid in the selection of patients who might benefit from secondary cytoreductive surgery and will be enrolled in the recently started randomized prospective DESKTOP III trial investigating the role of surgery in recurrent platinum-sensitive ovarian cancer.
authors.affiliation: Department of Gynecology & Gynecologic Oncology, Dr. Horst Schmidt Klinik, Wiesbaden, Germany. p.harter@kliniken-essen-mitte.de
authors.forename: Philipp
authors.initials: P
authors.lastname: Harter
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.forename: Alexander
authors.initials: A
authors.lastname: Reuss
authors.forename: Annette
authors.initials: A
authors.lastname: Hasenburg
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scambia
authors.forename: David
authors.initials: D
authors.lastname: Cibula
authors.forename: Sven
authors.initials: S
authors.lastname: Mahner
authors.forename: Ignace
authors.initials: I
authors.lastname: Vergote
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
authors.forename: Alexander
authors.initials: A
authors.lastname: Burges
authors.forename: Lars
authors.initials: L
authors.lastname: Hanker
authors.forename: Martin
authors.initials: M
authors.lastname: Pölcher
authors.forename: Christian
authors.initials: C
authors.lastname: Kurzeder
authors.forename: Ulrich
authors.initials: U
authors.lastname: Canzler
authors.forename: Karl Ulrich
authors.initials: KU
authors.lastname: Petry
authors.forename: Andreas
authors.initials: A
authors.lastname: Obermair
authors.forename: Edgar
authors.initials: E
authors.lastname: Petru
authors.forename: Barbara
authors.initials: B
authors.lastname: Schmalfeldt
authors.forename: Domenica
authors.initials: D
authors.lastname: Lorusso
authors.forename: Andreas
authors.initials: A
authors.lastname: du Bois
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000601:surgery*; D011446:Prospective Studies