title: IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton.
abstract: Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens' virulence is manipulation of the host cell's cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades. Research has shown that IQGAP1 binds to and modulates the activity of multiple proteins that participate in bacterial invasion. Here, we review data that support a role for IQGAP1 in infectious disease via its ability to regulate the actin cytoskeleton. In addition, we explore other mechanisms by which IQGAP1 may be exploited by microbial pathogens.
authors.affiliation: Department of Translational Medicine, Brigham and Women's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA.
authors.forename: Hugh
authors.initials: H
authors.lastname: Kim
authors.forename: Colin D
authors.initials: CD
authors.lastname: White
authors.forename: David B
authors.initials: DB
authors.lastname: Sacks
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000378:metabolism* / Q000382:microbiology* / Q000821:virology; D008954:Models, Biological; D015398:Signal Transduction; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
chemical_list: D000199:Actins; C101203:IQ motif containing GTPase activating protein 1; D020703:ras GTPase-Activating Proteins