title: Evaluation of the antipeptic ulcer activity of the leaf extract of Plantago lanceolata L. in rodents.
abstract: The effect of the leaf extract of Plantago lanceolata L. (Plantaginaceae) on gastric secretion and cytoprotection was evaluated using different models of gastroduodenal ulcer, including acetic acid induced chronic gastric ulcer, indomethacin induced gastric ulcer, cysteamine induced duodenal ulcer and pylorus ligation induced gastric ulcer. The aqueous extract was administered at 200 mg/kg and 400 mg/kg and 140 mg/kg and 280 mg/kg for mice and rats, respectively, and compared with vehicle or the standard, ranitidine (50 or 70 mg/kg) or misopristol (280 μg/kg). In addition, activity of the mucilage (172 mg/kg) was also evaluated in acetic acid induced chronic gastric ulcer. Administration was done orally except in pylorus ligation, where the intraduodenal route was used. In all cases, higher doses of the extract provided better protection than lower doses and the mucilage, hinting at a dose-dependent effect. Whilst higher doses of the extract showed a better healing of the ulcer as well as protection in indomethacin and pylorus ligation models, activities of lesser magnitude than ranitidine were noted in the cysteamine model. Together these findings indicate that higher doses used in the present study provided an overall better protection against gastroduodenal ulcers than the standard drugs employed through antisecretory and cytoprotective mechanisms.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Addis Ababa University, Ethiopia.
authors.forename: Endale
authors.initials: E
authors.lastname: Melese
authors.forename: Kaleab
authors.initials: K
authors.lastname: Asres
authors.forename: Mohammed
authors.initials: M
authors.lastname: Asad
authors.forename: Ephrem
authors.initials: E
authors.lastname: Engidawork
mesh_terms: D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003543:Cysteamine; D004195:Disease Models, Animal; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D005002:Ethiopia; D005260:Female; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010943:Plantago / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D003543:Cysteamine; D019342:Acetic Acid