title: Diurnally subperiodic filariasis in India-prospects of elimination: precept to action?
abstract: The elimination of lymphatic filariasis in the Andaman and Nicobar Islands provides unique opportunities and challenges at the same time. Since these islands are remote, are sparsely populated, and have poor transport networks, mass drug administration programs are likely to be difficult to implement. Diurnally subperiodic Wuchereria bancrofti vectored by Downsiomyia nivea was considered for the scope of vector control options. Considering the bioecology of this mosquito, vector control including personal protection measures may not be feasible. However, since these islands are covered by separate administrative machinery which also plays an important role in regulating the food supply, the use of diethylcarbamazine (DEC)-fortified salt as a tool for the interruption of transmission is appealing. DEC-fortified salt has been successfully pilot tested in India and elsewhere, operationally used by China for eliminating lymphatic filariasis. Administration of DEC-fortified salt though simple, rapid, safe, and cost-effective, challenges are to be tackled for translating this precept into action by evolving operationally feasible strategy. Although the use of DEC-fortified salt is conceptually simple, it requires commitment of all sections of the society, an elaborate distribution mechanism that ensures the use of DEC-fortified salt only in the endemic communities, and a vigorous monitoring mechanism. Here, we examine the inbuilt administrative mechanisms to serve the tribal people, health infrastructure, and public distribution system and discuss the prospects of putting in place an operationally feasible strategy for its elimination.
authors.affiliation: Division of Vector Borne Diseases, Regional Medical Research Centre (Indian Council of Medical Research), Post Bag No. 13, Port Blair 744101, Andaman and Nicobar Islands, India. shriraman@icmr.org.in
authors.forename: A N
authors.initials: AN
authors.lastname: Shriram
authors.forename: K
authors.initials: K
authors.lastname: Krishnamoorthy
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
authors.forename: Avijit
authors.initials: A
authors.lastname: Roy
authors.forename: V
authors.initials: V
authors.lastname: Kumaraswami
authors.forename: W A
authors.initials: WA
authors.lastname: Shah
authors.forename: P
authors.initials: P
authors.lastname: Jambulingam
authors.forename: P
authors.initials: P
authors.lastname: Vijayachari
mesh_terms: D000818:Animals; D009033:Culicidae / Q000469:parasitology; D004035:Diet Therapy / Q000379:methods*; D019587:Dietary Supplements; D004049:Diethylcarbamazine / Q000008:administration & dosage*; D005368:Filariasis / Q000453:epidemiology* / Q000517:prevention & control*; D005369:Filaricides / Q000008:administration & dosage*; D006801:Humans; D007194:India / Q000453:epidemiology; D014958:Wuchereria bancrofti / Q000302:isolation & purification*
chemical_list: D005369:Filaricides; D004049:Diethylcarbamazine