title: Antioxidative iridoid glycosides from the sky flower (Duranta repens Linn).
abstract: Phytochemical investigations were performed on the EtOAc-soluble fraction of the whole plant of the sky flower (Duranta repens) which led to the isolation of the iridoid glycosides 1-6. Their structures were elucidated by both 1D and 2D NMR spectroscopic analysis. All the compounds showed potent antioxidative scavenging activity in four different tests, with half maximal inhibitory concentration (IC(50)) values in the range 0.481-0.719 mM against DPPH radicals, 4.07-17.21 μM for the hydroxyl radical (·OH) inhibitory activity test, 43.3-97.37 μM in the total reactive oxygen species (ROS) inhibitory activity test, and 3.39-18.94 μM in the peroxynitrite (ONOO(-)) scavenging activity test. Duranterectoside A (1) displayed the strongest scavenging potential with IC(50) values of (0.481 ± 0.06 mM, 4.07 ± 0.03, 43.30 ± 0.05, 3.39 ± 0.02 μM) for the DPPH radicals, ·OH inhibitory activity test, total ROS inhibitory activity test and the ONOO(-) scavenging activity test, respectively.
authors.affiliation: KUST Institute of Medical Sciences, Kohat University of Science and Technology, Kohat, NWFP, Pakistan.
authors.forename: Fozia
authors.initials: F
authors.lastname: Ijaz
authors.forename: Azhar
authors.initials: A
authors.lastname: Ul Haq
authors.forename: Ijaz
authors.initials: I
authors.lastname: Ahmad
authors.forename: Nisar
authors.initials: N
authors.lastname: Ahmad
authors.forename: Javid
authors.initials: J
authors.lastname: Hussain
authors.forename: Sibao
authors.initials: S
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D035264:Flowers / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors; D057889:Iridoid Glycosides / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D030421:Peroxynitrous Acid / Q000037:antagonists & inhibitors; D010851:Picrates / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors; D029648:Verbenaceae / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D057889:Iridoid Glycosides; D010851:Picrates; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl