title: In vitro effects of neuropeptide Y in rat neocortical and hippocampal tissue.
abstract: Neuropeptide Y (NPY) network effects in hippocampus and frontal cortex and its impact on epileptiform neocortical discharges were investigated in rat juvenile brain slices. NPY (1 μM) reduced amplitudes of paired pulse stimulation in hippocampal brain tissue (p<0.05) whereas NPY (1 nM-2 μM) had no effect in neocortex. Late stage epileptiform activity in the neocortex was unaffected by NPY (1 μM). Our results point to a region dependent effect of NPY with a high impact on hippocampal and minimal impact on neocortical networks.
authors.affiliation: Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. skovac@ion.ucl.ac.uk
authors.forename: Stjepana
authors.initials: S
authors.lastname: Kovac
authors.forename: Maria
authors.initials: M
authors.lastname: Megalogeni
authors.forename: Matthew
authors.initials: M
authors.lastname: Walker
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D004827:Epilepsy / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D019579:Neocortex / Q000187:drug effects / Q000502:physiology*; D009478:Neuropeptide Y / Q000494:pharmacology / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009478:Neuropeptide Y