title: Unusual anatomic location of a primary intracranial yolk sac tumor.
abstract: A nongerminomatous germ cell tumor occurring in the brain parenchyma is extremely rare. A 2-year-old boy presented with symptoms of abnormal movements in the hand and mouth. MRI scanning revealed a lesion occupying the left temporoparietal region. Craniotomy was performed and the tumor was removed by en bloc resection. Histological examination revealed that the tumor was arranged in a reticular pattern, and Schiller-Duval bodies were evident at the center of the tumor. Immunohistochemical study showed that the tumor cells were positive for alpha-fetoprotein and vimentin, but negative for glial fibrillary acidic protein. The histological diagnosis was pure yolk sac tumor.
authors.affiliation: Department of Pathology, Jordan University Hospital, Amman, Jordan.
authors.forename: Anwar A
authors.initials: AA
authors.lastname: Al-Masri
authors.forename: Nidal H
authors.initials: NH
authors.lastname: Khasawneh
authors.forename: Tariq N
authors.initials: TN
authors.lastname: Aladily
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002675:Child, Preschool; D003399:Craniotomy / Q000379:methods; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D014746:Vimentin; D000509:alpha-Fetoproteins