title: Bone marrow fibrosis in myeloproliferative neoplasms-associated myelofibrosis: deconstructing a myth?
abstract: The dominant pathophysiological and clinical features of myeloproliferative neoplasm (MPN)-associated myelofibrosis are caused by bone marrow fibrosis. It is widely believed this fibrosis is a reaction to the MPN-clone implying the cells causing fibrosis are polyclonal and genetically unrelated to the MPN-clone. We cite recent data illustrating the complexity of cell types comprising the bone marrow micro-environment and showing that at least some of the cells responsible for bone marrow fibrosis are clonal and genetically related to the MPN-clone.
authors.affiliation: Laboratory of Clinical Epidemiology and Center for the Study of Myelofibrosis, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barosi
authors.forename: Robert Peter
authors.initials: RP
authors.lastname: Gale
mesh_terms: D002999:Clone Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D003210:Concept Formation; D016207:Cytokines / Q000378:metabolism / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000502:physiology; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000276:immunology; D009229:Mythology; D009369:Neoplasms / Q000150:complications* / Q000276:immunology; D055728:Primary Myelofibrosis / Q000150:complications* / Q000209:etiology* / Q000276:immunology
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins