title: Brain insulin controls adipose tissue lipolysis and lipogenesis.
abstract: White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1055, New York, NY 10029-6574, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Scherer
authors.forename: James
authors.initials: J
authors.lastname: O'Hare
authors.forename: Kelly
authors.initials: K
authors.lastname: Diggs-Andrews
authors.forename: Martina
authors.initials: M
authors.lastname: Schweiger
authors.forename: Bob
authors.initials: B
authors.lastname: Cheng
authors.forename: Claudia
authors.initials: C
authors.lastname: Lindtner
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Zielinski
authors.forename: Prashant
authors.initials: P
authors.lastname: Vempati
authors.forename: Kai
authors.initials: K
authors.lastname: Su
authors.forename: Shveta
authors.initials: S
authors.lastname: Dighe
authors.forename: Thomas
authors.initials: T
authors.lastname: Milsom
authors.forename: Michelle
authors.initials: M
authors.lastname: Puchowicz
authors.forename: Ludger
authors.initials: L
authors.lastname: Scheja
authors.forename: Rudolf
authors.initials: R
authors.lastname: Zechner
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Fisher
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Previs
authors.forename: Christoph
authors.initials: C
authors.lastname: Buettner
mesh_terms: D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D050155:Lipogenesis; D008066:Lipolysis; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D007328:Insulin; D011972:Receptor, Insulin; D005947:Glucose