title: Radiotherapy planning in high-grade gliomas: a survey of current UK practice.
abstract: OBJECTIVE
  Primary brain tumours in adults are rare, with high-grade gliomas (HGG) being the most common and most aggressive type. The clinical management of rare tumours such as HGG can be heterogeneous across different cancer centres. The aim of this survey was to determine current UK practice in the primary management of HGG, particularly in light of the improved outcomes reported recently.
  
  
  METHODS
  In February 2009, a questionnaire was sent to 71 consultant clinical oncologists in the UK who were reported to have a neuro-oncology practice. Questions focussed on the radiotherapeutic management of HGG.
  
  
  RESULTS
  In total, 46/71 (65%) completed questionnaires were returned; 31/46 (67%) routinely used magnetic resonance imaging/computed tomography fusion for radiotherapy planning; 34/36 (94%) routinely prescribed 60Gy in 30 fractions in a single phase; 7/36 (19%) would consider 54-55Gy in 30 fractions in selected clinical scenarios; 42/46 (91%) defined the planning target volume (PTV) as the gross tumour volume (GTV)+2-3cm margin and 42/46 (91%) outlined at least one 'organ at risk' (OAR). Accepted tolerance doses varied considerably, e.g. retina range: 30-54Gy. Sixty-four per cent of clinicians (27/42) compromise the PTV and 30% (14/42) the GTV in order to keep OARs within preset tolerances. Nearly one-third (14/42) involve the patient in this decision-making process, e.g. weighing up the risk of late toxicity with the risks of reducing the dose to the PTV.
  
  
  CONCLUSIONS
  The results of this survey show areas of strong agreement as well as areas of variation in clinical practice of aspects of treatment planning for HGG between UK neuro-oncologists.
authors.affiliation: The Royal Marsden Foundation Trust, Downs Road, Sutton, Surrey, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Creak
authors.forename: A
authors.initials: A
authors.lastname: Tree
authors.forename: F
authors.initials: F
authors.lastname: Saran
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003625:Data Collection; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D018787:Radiation Oncology / Q000592:standards*; D011880:Radiotherapy Planning, Computer-Assisted; D006113:United Kingdom