title: Prevalence of anticardiolipin antibody in Bangladeshi patients with recurrent pregnancy loss.
abstract: The objective of the present study was to see the prevalence of anticardiolipin antibody (ACA) in Bangladeshi patients (35) with recurrent pregnancy loss. Thirty-seven women with normal pregnancy were included as control. Serum levels (mean +/- SD) of ACA (u/mL) was significantly higher, whereas ANA (Ab-index) and anti-dsDNA (Ab-index) were similar in cases compared to controls (Cases vs Controls --> ACA: 31.8 +/- 24.3 vs 10.5 +/- 3.4, p < 0.001; ANA: 1.07 +/- 0.34 vs 0.92 +/- 0.15, p > 0.5; A-dsDNA: 0.53 +/- 0.16 vs 0.52 +/- 0.18, p > 0.5). The cases positive for ACA, ANA and anti-dsDNA were 37.1% (p < 0.001), 20% (p > 0.05) and 2.8% (p > 0.1) respectively. Among the seropositive cases 4/35 (11.4%) and 4/13 (30.8%) were positive for both ACA and ANA. In controls only 2/37 (5.4%) and 2/37 (5.4%) were positive for ACA and ANA respectively and none were positive for both ACA and ANA together simultaneously. Significantly high proportion of cases had O positive blood group (23/35: 65.7%, 10/13: 76.9%) (p < 0.01). The prevalence of ACA varies according to population being 37.1% (13/35) in our patients with recurrent pregnancy loss and 5.4% in controls.
authors.affiliation: Department of Biochemistry, Medical College for Women & Hospital, Uttara Model Town, Dhaka 1230, Bangladesh. asmgias@hotmail.com
authors.forename: A S M
authors.initials: AS
authors.lastname: Giasuddin
authors.forename: Ishrat
authors.initials: I
authors.lastname: Mazhar
authors.forename: A M Mujibul
authors.initials: AM
authors.lastname: Haq
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D000974:Antibodies, Antinuclear / Q000097:blood; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D011247:Pregnancy; D012008:Recurrence
chemical_list: D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D004247:DNA