title: Modeling neurodegeneration in zebrafish.
abstract: The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson's, Huntington's, and Alzheimer's. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.
authors.affiliation: Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie, Ottawa, Ontario K1N6N5, Canada.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Xi
authors.forename: Sandra
authors.initials: S
authors.lastname: Noble
authors.forename: Marc
authors.initials: M
authors.lastname: Ekker
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006816:Huntington Disease / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D026502:LDL-Receptor Related Proteins / Q000235:genetics; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D026901:Membrane Transport Proteins / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000473:pathology* / Q000503:physiopathology*; D015513:Oncogene Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D015027:Zebrafish / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics; D000099202:PTEN-Induced Putative Kinase
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D026502:LDL-Receptor Related Proteins; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D026901:Membrane Transport Proteins; D015513:Oncogene Proteins; D000071617:Protein Deglycase DJ-1; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D044767:Ubiquitin-Protein Ligases; D016875:tau Proteins; D000099202:PTEN-Induced Putative Kinase; C102582:SORL1 protein, human; C111567:parkin protein; C495280:LRRK2 protein, human; C105131:PARK7 protein, human