title: Lipid raft redox signaling: molecular mechanisms in health and disease.
abstract: Lipid rafts, the sphingolipid and cholesterol-enriched membrane microdomains, are able to form different membrane macrodomains or platforms upon stimulations, including redox signaling platforms, which serve as a critical signaling mechanism to mediate or regulate cellular activities or functions. In particular, this raft platform formation provides an important driving force for the assembling of NADPH oxidase subunits and the recruitment of other related receptors, effectors, and regulatory components, resulting, in turn, in the activation of NADPH oxidase and downstream redox regulation of cell functions. This comprehensive review attempts to summarize all basic and advanced information about the formation, regulation, and functions of lipid raft redox signaling platforms as well as their physiological and pathophysiological relevance. Several molecular mechanisms involving the formation of lipid raft redox signaling platforms and the related therapeutic strategies targeting them are discussed. It is hoped that all information and thoughts included in this review could provide more comprehensive insights into the understanding of lipid raft redox signaling, in particular, of their molecular mechanisms, spatial-temporal regulations, and physiological, pathophysiological relevances to human health and diseases.
authors.affiliation: Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Jinsi@mail.hust.edu.cn
authors.forename: Si
authors.initials: S
authors.lastname: Jin
authors.forename: Fan
authors.initials: F
authors.lastname: Zhou
authors.forename: Foad
authors.initials: F
authors.lastname: Katirai
authors.forename: Pin-Lan
authors.initials: PL
authors.lastname: Li
mesh_terms: D002518:Ceramides / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004194:Disease; D006262:Health; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000502:physiology; D019255:NADPH Oxidases / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002518:Ceramides; D002784:Cholesterol; D019255:NADPH Oxidases