title: Cell renewal in adjoining intestinal and tracheal epithelia of Manduca.
abstract: Cell renewal continuously replaces dead or dying cells in organs such as human and insect intestinal (midgut) epithelia; in insects, control of self-renewal determines insects' responses to any of the myriad pathogens and parasites of medical and agricultural importance that enter and cross their midgut epithelia. Regenerative cells occur in the midgut epithelia of many, if not all, insects and are probably derived from a distinctive population of stem cells. The control of proliferation and differentiation of these midgut regenerative cells is assumed to be regulated by an environment of adjacent cells that is referred to as a regenerative cell niche. An antibody to fasciclin II marks cell surfaces of tracheal regenerative cells associated with rapidly growing midgut epithelia. Tracheal regenerative cells and their neighboring midgut regenerative cells proliferate and differentiate in concert during the coordinated growth of the midgut and its associated muscles, nerves and tracheal cells.
authors.affiliation: Department of Entomology, University of Illinois, 320 Morrill Hall, 505 S. Goodwin Avenue, Urbana, IL 61801, United States. j-nardi@uiuc.edu
authors.forename: James B
authors.initials: JB
authors.lastname: Nardi
authors.forename: Charles Mark
authors.initials: CM
authors.lastname: Bee
authors.forename: Lou Ann
authors.initials: LA
authors.lastname: Miller
authors.forename: Divya
authors.initials: D
authors.lastname: Mathur
authors.forename: Benjamin
authors.initials: B
authors.lastname: Ohlstein
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000166:cytology*; D007422:Intestines / Q000166:cytology / Q000196:embryology; D007814:Larva / Q000166:cytology / Q000254:growth & development; D018402:Manduca / Q000166:cytology* / Q000196:embryology; D014132:Trachea / Q000166:cytology / Q000196:embryology