title: Iris as a reflector for differential absorption low-coherence interferometry to measure glucose level in the anterior chamber.
abstract: We present a method of glucose concentration detection in the anterior chamber with a differential absorption optical low-coherent interferometry (LCI) technique. Back-reflected light from the iris, passing through the anterior chamber twice, was selectively obtained with the LCI technique. Two light sources, one centered within (1625 nm) and the other centered outside (1310 nm) of a glucose absorption band were used for differential absorption measurement. In the eye model and pig eye experiments, we obtained a resolution glucose level of 26.8 mg∕dL and 69.6 mg∕dL, respectively. This method has a potential application for noninvasive detection of glucose concentration in aqueous humor, which is related to the glucose concentration in blood.
authors.affiliation: Tsinghua University, Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen, 518055, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Nan
authors.initials: N
authors.lastname: Zeng
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Ji
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Xiangsong
authors.initials: X
authors.lastname: Dai
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Lian
authors.initials: L
authors.lastname: Duan
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000737:chemistry*; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005947:Glucose / Q000032:analysis*; D007368:Interferometry / Q000295:instrumentation*; D007498:Iris / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine; D041623:Tomography, Optical Coherence / Q000295:instrumentation*
chemical_list: D005947:Glucose