title: Update on some aspects of neonatal thyroid disease.
abstract: This article explores the basic development and pathophysiology of the thyroid gland. New factors in the normal development of the thyroid in the neonate are mentioned. The incidence of congenital hypothyroidism continues to increase. We describe congenital hypothyroidism, its possible etiologies, treatment and outcomes. We explore hypothyroxinanemia in pre-term neonates and the risk/benefit of prophylactic thyroid hormone replacement. We discuss the late rise of thyrotropin (TSH) in ill infants and those with very low birth weight. Ill infants or those born premature should have their thyroid function tests routinely monitored. On the occasion of borderline thyroid function test results, TRH testing can be useful in identifying those infants with either persistent or transient hypothyroidism. TRH testing is also helpful in identifying those patients with secondary hypothyroidism. With the early identification and prompt and proper treatment, neonates with congenital hypothyroidism, transient or persistent, should have positive long-term outcomes.
authors.affiliation: Mount Sinai School of Medicine, Pediatric Endocrinology, New York, NY, USA. tamar.simpser@gmail.com
authors.forename: Tamar
authors.initials: T
authors.lastname: Simpser
authors.forename: Robert
authors.initials: R
authors.lastname: Rapaport
mesh_terms: D003409:Congenital Hypothyroidism / Q000097:blood / Q000628:therapy; D006042:Goiter / Q000151:congenital; D020249:Hormone Replacement Therapy; D006801:Humans; D007231:Infant, Newborn; D013959:Thyroid Diseases / Q000151:congenital* / Q000235:genetics; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D014157:Transcription Factors; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014157:Transcription Factors; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine