title: Advances in understanding ischemic acute kidney injury.
abstract: Acute kidney injury (AKI) is independently associated with increased morbidity and mortality. Ischemia is the leading cause of AKI, and short of supportive measures, no currently available therapy can effectively treat or prevent ischemic AKI. This paper discusses recent developments in the understanding of ischemic AKI pathophysiology, the emerging relationship between ischemic AKI and development of progressive chronic kidney disease, and promising novel therapies currently under investigation. On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future.
authors.affiliation: Department of Pediatrics, Division of Nephrology, University of Washington and Seattle Children’s Hospital, Seattle, WA, USA.
authors.forename: Raj
authors.initials: R
authors.lastname: Munshi
authors.forename: Christine
authors.initials: C
authors.lastname: Hsu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Himmelfarb
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology*; D000818:Animals; D018450:Disease Progression; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D007511:Ischemia / Q000473:pathology*; D019194:Ischemic Preconditioning; D007676:Kidney Failure, Chronic / Q000473:pathology; D015427:Reperfusion Injury / Q000473:pathology
chemical_list: D051793:Hypoxia-Inducible Factor 1