title: Long-term prognosis and comorbidities associated with psoriasis in the Newfoundland and Labrador founder population.
abstract: BACKGROUND
  Psoriasis is a common chronic immune-mediated inflammatory disorder of the skin with several associated comorbidities.
  
  
  OBJECTIVE
  To assess the prevalence of comorbidities in a cohort of psoriasis patients within the Canadian province of Newfoundland and Labrador (NL).
  
  
  METHODS
  This cross-sectional observational study investigated hospital-coded comorbidities associated with psoriasis in comparison to the general NL hospitalized population.
  
  
  RESULTS
  Patients died significantly younger than the general population, with patients having an earlier disease onset (≤ 25 years) dying at a younger age than those with a later onset (> 25 years; 59.3 vs 71.2; p  =  .001). Patients were hospitalized more frequently for several system disorders than the general population, and a potential association was observed between prognostic factors such as age at onset, disease severity, and HLA-Cw6 genotype and certain comorbid conditions.
  
  
  CONCLUSIONS
  This study supports an association between psoriasis and other conditions, such as circulatory and endocrine diseases.
authors.affiliation: Disciple of Medicine, Faculty of Medicine, Memorial University of Newfoundland. wgulliver@newlabresearch.com
authors.forename: Wayne P
authors.initials: WP
authors.lastname: Gulliver
authors.forename: Don
authors.initials: D
authors.lastname: Macdonald
authors.forename: Neil
authors.initials: N
authors.lastname: Gladney
authors.forename: Reza
authors.initials: R
authors.lastname: Alaghehbandan
authors.forename: Proton
authors.initials: P
authors.lastname: Rahman
authors.forename: K
authors.initials: K
authors.lastname: Adam Baker
mesh_terms: D000328:Adult; D002423:Cause of Death; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D018703:Founder Effect; D006801:Humans; D008297:Male; D008498:Medical Record Linkage; D008875:Middle Aged; D009523:Newfoundland and Labrador / Q000453:epidemiology; D011379:Prognosis; D011565:Psoriasis / Q000453:epidemiology*