title: Chromosome segregation: keeping kinetochores in the loop.
abstract: The Ndc80 complex is a key component of the kinetochore-microtubule interface. Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 plays an unexpected role in recruiting proteins to the kinetochore.
authors.affiliation: Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA.
authors.forename: Jens C
authors.initials: JC
authors.lastname: Schmidt
authors.forename: Iain M
authors.initials: IM
authors.lastname: Cheeseman
mesh_terms: D020090:Chromosome Segregation; D018386:Kinetochores / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D008954:Models, Biological; D009687:Nuclear Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D012568:Schizosaccharomyces / Q000378:metabolism / Q000648:ultrastructure
chemical_list: C112472:NDC80 protein, S cerevisiae; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins