title: The changing occurrences of tetralogy of Fallot and simple transposition of the great arteries in Southern Nevada.
abstract: We analysed the occurrence of tetralogy of Fallot and simple transposition in the Hispanic and non-Hispanic populations of Clark County, Nevada, in the United States of America over a 30-year period from 1980 to 2009. We found a downward trend in the incidence of simple transposition of the great arteries in the non-Hispanic population but an upward trend in the incidence in the Hispanic population. For tetralogy of Fallot, we found an upward trend in the incidence in both populations; the trend, however, was more dramatic in the Hispanic population. We also noted differences in the male to female ratios in the different groups. Even though we make no definitive conclusions regarding the causes of these incidence curves or the differences in occurrence between males or females, the data suggest an interplay of genetics and the environment.
authors.affiliation: Children’s Heart Center, 3006 South Maryland Parkway, Las Vegas, NV 89109, USA. WNevans50@aol.com
authors.forename: William N
authors.initials: WN
authors.lastname: Evans
authors.forename: Ruben J
authors.initials: RJ
authors.lastname: Acherman
authors.forename: William J
authors.initials: WJ
authors.lastname: Castillo
authors.forename: Humberto
authors.initials: H
authors.lastname: Restrepo
mesh_terms: D016208:Databases, Factual; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D009505:Nevada / Q000453:epidemiology; D011296:Prenatal Diagnosis; D013771:Tetralogy of Fallot / Q000175:diagnosis / Q000453:epidemiology*; D014188:Transposition of Great Vessels / Q000175:diagnosis / Q000453:epidemiology*