title: Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment.
abstract: OBJECTIVE
  To report the case of a patient with factor V deficiency who achieved pregnancy with the planned transfusion of fresh frozen plasma (FFP) while monitoring follicle development and ovulation induction using gonadotropin.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 28-year-old nulliparous female.
  
  
  METHODS
  Medical management including infertility treatment.
  
  
  METHODS
  Clinical follow-up.
  
  
  RESULTS
  A patient with factor V deficiency experienced repeated ovulation-related hemoperitoneum following the withdrawal of oral contraceptive pills. The monitoring of follicle development and ovulation induction using gonadotropin followed by FFP transfusion was useful to avoid hemoperitoneum. Pregnancy was achieved within a relatively short period using intrauterine insemination.
  
  
  CONCLUSIONS
  Planned prophylactic FFP administration and intervention with infertility treatment might be useful to minimize the risk of ovulation-related hemoperitoneum in patients with factor V deficiency.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, and Department of Maternal and Perinatal Medicine, Nagoya University Hospital, Nagoya, Japan. akiwase@med.nagoya-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Iwase
authors.forename: Maki
authors.initials: M
authors.lastname: Goto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Manabe
authors.forename: Wakana
authors.initials: W
authors.lastname: Hirokawa
authors.forename: Hiroharu
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakahara
authors.forename: Sachiko
authors.initials: S
authors.lastname: Takikawa
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kotani
authors.forename: Seiji
authors.initials: S
authors.lastname: Sumigama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakayama
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsushita
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D001803:Blood Transfusion / Q000379:methods*; D005166:Factor V Deficiency / Q000097:blood / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000150:complications / Q000628:therapy*; D010934:Planning Techniques; D010949:Plasma; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000628:therapy*; D027724:Reproductive Techniques, Assisted