title: Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis.
abstract: BACKGROUND
  The aim of the present study was to compare bone mineral density (BMD) and body composition (BC) measurements as well as identify risk factors for low BMD and osteoporotic fractures in postmenopausal women with psoriasis (Ps) and psoriatic arthritis (PsA).
  
  
  METHODS
  A cross-sectional study was carried out in 45 PsA women, 52 Ps women and 98 healthy female controls (HC). Clinical risk factors for low bone density and osteoporotic fracture were evaluated by a specific questionnaire. An X-ray absorptiometry (DXA) at the lumbar spine, total femur and total body was performed on all patients. Skin and joint outcomes were measured by specific tools (PASI, HAQ and DAS28). Morphometric vertebral fractures were evaluated by lumbar and thoracic spine X-ray, according to Genant's method.
  
  
  RESULTS
  There were no significant differences in age, body mass index (BMI), total lean mass and bone mineral density among the groups. However, the PsA group had a significantly higher body fat percentage (BF%) than the Ps and HC groups. Osteoporotic fractures were more frequently observed in PsA and Ps groups than in the HC group (P = 0.01). Recurrent falls and a longer duration of disease increased the risk of fracture (odds ratio (OR) = 18.3 and 1.08, respectively) in the PsA group (P = 0.02). Disability was the main factor related to osteoporotic fracture in the Ps group (odds ratio (OR) = 11.1) (P = 0.02).
  
  
  CONCLUSIONS
  Ps and PsA patients did not present lower BMD. However, they had a higher prevalence of osteoporotic fractures and higher risk of metabolic syndrome. Patients with a longer duration of disease, disability and recurrent falls need preventive measures.
authors.affiliation: Rheumatology Division, Federal University of São Paulo, UNIFESP/Paulista School of Medicine, EPM, 740, Botucatu Street, 04023-900 São Paulo-SP, Brazil. ppedreira@hotmail.com
authors.forename: Paulo G
authors.initials: PG
authors.lastname: Pedreira
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Pinheiro
authors.forename: Vera L
authors.initials: VL
authors.lastname: Szejnfeld
mesh_terms: D015502:Absorptiometry, Photon; D015535:Arthritis, Psoriatic / Q000150:complications / Q000503:physiopathology*; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000453:epidemiology*; D058866:Osteoporotic Fractures / Q000150:complications / Q000453:epidemiology*; D017698:Postmenopause / Q000502:physiology; D015995:Prevalence; D011565:Psoriasis / Q000150:complications / Q000503:physiopathology*; D012307:Risk Factors