title: Strategies for localisation of impalpable breast lesions.
abstract: With advances in the sensitivity of mammographic screening and the broader population of women screened via national programmes. More than 50% of all new breast cancers in the United Kingdom are screen-detected and of the 11,110 invasive breast cancers (78.7 per cent of all UK cancers) detected in the year 2007-2008, 5814 (52.3 per cent) measured 15 mm or less in diameter and were deemed clinically non-palpable. For excision of non-palpable lesions, localisation techniques are currently largely limited to wire-guided localisation with the associated risks of migration, transection and scheduling conflicts. In this review we will describe the current gold-standard of wire-guided localisation (WGL), its associated merits and limitations before reporting on the data available for Radioguided Occult Lesion Localisation (ROLL) and Radiolabeled Seed Localisation (RSL) trials.
authors.affiliation: Department of Surgery, Royal Free Hospital, Pond Street, London, UK. saschadua@hotmail.com
authors.forename: Sascha Miles
authors.initials: SM
authors.lastname: Dua
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gray
authors.forename: Mohammed
authors.initials: M
authors.lastname: Keshtgar
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000295:instrumentation / Q000379:methods*; D010173:Palpation; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals