title: [Autophagy and pathogens: «Bon appétit Messieurs!»].
abstract: Autophagy is a highly conserved, self-degradative pathway for clearance and recycling of cytoplasmic contents. This ubiquitous cell intrinsic process can be used as a defence mechanism against intracellular pathogens. Indeed autophagy is increased upon pathogen detection, and experimental extinction in vitro and in vivo of this cellular process has been demonstrated as a crucial role to control intracellular pathogens. Co-evolution between host-cells and pathogens has selected numerous micoorganisms able to avoid or usurp autophagy to their own benefit. Understanding mechanisms underlying the anti-microbial properties of autophagy as well as those used by certain pathogens to escape this cellular process might be crucial to manipulate this cellular function in order to prevent or treat infectious diseases.
authors.affiliation: Inserm U851, Université de Lyon 1, IFR128, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France.
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Joubert
authors.forename: Isabel
authors.initials: I
authors.lastname: Pombo Grégoire
authors.forename: Grégory
authors.initials: G
authors.lastname: Meiffren
authors.forename: Chantal
authors.initials: C
authors.lastname: Rabourdin-Combe
authors.forename: Mathias
authors.initials: M
authors.lastname: Faure
mesh_terms: D000818:Animals; D001343:Autophagy; D018407:Bacterial Physiological Phenomena; D002477:Cells / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D005057:Eukaryotic Cells / Q000502:physiology; D006678:HIV / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D007370:Interferon Type I / Q000502:physiology; D008561:Membrane Fusion; D008954:Models, Biological; D010588:Phagosomes / Q000502:physiology; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D051192:Receptors, Pattern Recognition / Q000502:physiology; D012641:Selection, Genetic; D025841:Small Ubiquitin-Related Modifier Proteins / Q000502:physiology; D056811:Unfolded Protein Response / Q000502:physiology
chemical_list: D007370:Interferon Type I; D051192:Receptors, Pattern Recognition; D025841:Small Ubiquitin-Related Modifier Proteins; D046988:Proteasome Endopeptidase Complex