title: The length of peritoneal surgical manipulation correlates with serum CA 125 levels.
abstract: BACKGROUND
  Peritoneal recovery after uncomplicated serum manipulation usually lasts 7 days and high values of serical CA 125 are measured following abdominal surgery. The aim of this study was to assess a possible correlation between peritoneal manipulation and serical CA 125 levels following abdominal surgery for benign diseases.
  
  
  METHODS
  Twenty-eight patients with abdominal benign disease were operated on. They were pooled into three groups of low, intermediate and high peritoneal manipulation, according to the extent of laparotomy and length of surgical peritoneal manipulation. Venous blood samples (5 ml) were taken from each patient 24-48 hours before surgery, 12-24 hours after surgery and on the 4th and 7th postoperative day. CA 125 levels were quantified by microparticle enzyme immunoassay.
  
  
  RESULTS
  After surgery, patients having high peritoneal manipulation showed significantly higher levels of CA 125 compared to the preoperative levels. In particular, the length of peritoneal manipulation was correlated with increasing levels of the marker (p<0.0001).
  
  
  CONCLUSIONS
  Peritoneal manipulation was significantly correlated to serum CA 125 levels; therefore its role as marker of peritoneal surgical injury should be considered.
authors.affiliation: Department of Surgical Sciences, Faculty of Medicine and Surgery, University of Udine, P.le Santa Maria della Misericordia 15-33100 Udine, Italy. enricomaria.pasqual@uniud.it
authors.forename: Enricomaria
authors.initials: E
authors.lastname: Pasqual
authors.forename: Stefano
authors.initials: S
authors.lastname: Bacchetti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Morabito
authors.forename: Serena
authors.initials: S
authors.lastname: Bertozzi
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Cagol
authors.forename: Dino
authors.initials: D
authors.lastname: De Anna
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D010532:Peritoneal Diseases / Q000097:blood* / Q000601:surgery*; D010537:Peritoneum / Q000601:surgery*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins