title: [Expression and significance of matrix metalloproteinases and their tissue inhibitors in the infiltration and metastasis of lung cancer].
abstract: BACKGROUND
  To determine the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in lung cancer specimens, and to find out the possible roles of MMPs and TIMPs in the infiltration and metastasis of lung cancer.
  
  
  METHODS
  The expression of MMP-1, MMP-2, MMP-9, MMP-13, TIMP-1, TIMP-2 were detected in 104 lung cancer tissues by immunohistochemical method.
  
  
  RESULTS
  The expressions of MMPs and TIMPs were up-regulated in lung cancer tissues. The expression of MMP-2 was related to differentiated degree of tumor cells. MMP-9 correlated with lymph node metastasis of lung cancer. The positive rate of TIMP-1 was related to TNM stage and lymph node metastasis. In lung cancer tissues, there was positive correlation between MMP-2 and TIMP-2, and between MMP-9 and TIMP-2.
  
  
  CONCLUSIONS
  MMPs and TIMPs may play the important roles in the development of lung cancer. MMP-9 and TIMP-1 might promote the infiltration and metastasis of lung cancer.
authors.affiliation: Department of Pathology, Tianjin Medical University, Tianjin 300070, P.R.China.
authors.forename: Xinyun
authors.initials: X
authors.lastname: Wang
authors.forename: Juhong
authors.initials: J
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zheng
authors.forename: Bo
authors.initials: B
authors.lastname: Cheng
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zheng
authors.forename: Congzhong
authors.initials: C
authors.lastname: Zhu