title: Early lifetime zinc supplementation protects zinc-deficient diet-induced alterations.
abstract: Preclinical and clinical data indicate the involvement of zinc in the pathophysiology and therapy of depression. A relationship between zinc-deficiency and depression symptoms was recently proposed. The present study investigated alterations in spontaneous locomotor activity and zinc concentrations in the serum, hippocampus and frontal cortex; these alterations were induced by subjecting rats to a zinc-deficient diet, prior subjected after birth to zinc-supplemented diet. Body weight was significantly reduced in animals subjected to the four-week zinc-deficient diet compared to those subjected to the zinc-adequate diet. The two-week zinc-deficient diet induced a significant increase in locomotor activity in all measured time periods (5, 30 and 60 min by 44-62%). The four-week zinc-deficient diet did not affect locomotor activity, while the six-week zinc-deficient diet resulted in a 45% increase in the 5 min time period. Serum zinc concentrations were significantly reduced (by 29%) in animals subjected to the four-week zinc-deficient diet but not in those subjected to the two- or six-week zinc-deficient diets. The zinc-deficient diet did not influence the zinc concentration in the examined brain regions regardless of the length. These results indicate that post-birth supplementation with zinc may protect zinc-deficient diet-induced rapid alterations in zinc homeostasis.
authors.affiliation: Department of Inorganic Chemistry, Jagiellonian University, Collegium Medicum, Medyczna 9, PL 30-688 Kraków, Poland. w-opoka@o2.pl
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Opoka
authors.forename: Magdalena
authors.initials: M
authors.lastname: Sowa-Kućma
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Stachowicz
authors.forename: Beata
authors.initials: B
authors.lastname: Ostachowicz
authors.forename: Marek
authors.initials: M
authors.lastname: Szlósarczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Stypuła
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Młyniec
authors.forename: Anna
authors.initials: A
authors.lastname: Maślanka
authors.forename: Bogusław
authors.initials: B
authors.lastname: Baś
authors.forename: Marek
authors.initials: M
authors.lastname: Lankosz
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nowak
mesh_terms: D000818:Animals; D001835:Body Weight; D004032:Diet; D019587:Dietary Supplements; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008903:Minerals / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood / Q000172:deficiency* / Q000378:metabolism; D017967:Zinc Compounds / Q000008:administration & dosage*
chemical_list: D008903:Minerals; D017967:Zinc Compounds; D015032:Zinc