title: An assessment of orofacial clefts in Tanzania.
abstract: BACKGROUND
  Clefts of the lip (CL), the palate (CP), or both (CLP) are the most common orofacial congenital malformations found among live births, accounting for 65% of all head and neck anomalies. The frequency and pattern of orofacial clefts in different parts of the world and among different human groups varies widely. Generally, populations of Asian or Native American origin have the highest prevalence, while Caucasian populations show intermediate prevalence and African populations the lowest. To date, little is known regarding the epidemiology and pattern of orofacial clefts in Tanzania.
  
  
  METHODS
  A retrospective descriptive study was conducted at Bugando Medical Centre to identify all children with orofacial clefts that attended or were treated during a period of five years. Cleft lip and/or palate records were obtained from patient files in the Hospital's Departments of Surgery, Paediatrics and medical records. Age at presentation, sex, region of origin, type and laterality of the cleft were recorded. In addition, presence of associated congenital anomalies or syndromes was recorded.
  
  
  RESULTS
  A total of 240 orofacial cleft cases were seen during this period. Isolated cleft lip was the most common cleft type followed closely by cleft lip and palate (CLP). This is a departure from the pattern of clefting reported for Caucasian and Asian populations, where CLP or isolated cleft palate is the most common type. The distribution of clefts by side showed a statistically significant preponderance of the left side (43.7%) (χ2 = 92.4, p < 0.001), followed by the right (28.8%) and bilateral sides (18.3%). Patients with isolated cleft palate presented at very early age (mean age 1.00 years, SE 0.56). Associated congenital anomalies were observed in 2.8% of all patients with orofacial clefts, and included neural tube defects, Talipes and persistent ductus arteriosus.
  
  
  CONCLUSIONS
  Unilateral orofacial clefts were significantly more common than bilateral clefts; with the left side being the most common affected side. Most of the other findings did not show marked differences with orofacial cleft distributions in other African populations.
authors.affiliation: Department of Anatomy, Bugando University College of Health Sciences, Mwanza, Tanzania. manyama73@yahoo.com
authors.forename: Mange
authors.initials: M
authors.lastname: Manyama
authors.forename: Campbell
authors.initials: C
authors.lastname: Rolian
authors.forename: Japhet
authors.initials: J
authors.lastname: Gilyoma
authors.forename: Cassian C
authors.initials: CC
authors.lastname: Magori
authors.forename: Kilalo
authors.initials: K
authors.lastname: Mjema
authors.forename: Erick
authors.initials: E
authors.lastname: Mazyala
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Kimwaga
authors.forename: Benedikt
authors.initials: B
authors.lastname: Hallgrimsson
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology; D000293:Adolescent; D000367:Age Factors; D000539:Alveolar Process / Q000002:abnormalities; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000453:epidemiology*; D002972:Cleft Palate / Q000453:epidemiology*; D003025:Clubfoot / Q000453:epidemiology; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000453:epidemiology; D007223:Infant; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D016135:Spinal Dysraphism / Q000453:epidemiology; D013636:Tanzania / Q000453:epidemiology