title: Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor.
abstract: Salsolinol (1), a tetrahydroisoquinoline alkaloid, was isolated from the marine sponge Xestospongia cf. vansoesti collected in Indonesia as a proteasome inhibitor, along with three salsolinol derivatives, norsalsolinol (2), cis-4-hydroxysalsolinol (3), and trans-4-hydroxysalsolinol (4). Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC(50) values of 50 and 32 µg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 µg/ml.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nagasawa
authors.forename: Reiko
authors.initials: R
authors.lastname: Ueoka
authors.forename: Rumi
authors.initials: R
authors.lastname: Yamanokuchi
authors.forename: Naoki
authors.initials: N
authors.lastname: Horiuchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Henki
authors.initials: H
authors.lastname: Rotinsulu
authors.forename: Remy E P
authors.initials: RE
authors.lastname: Mangindaan
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Ukai
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirota
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Yokosawa
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D006367:HeLa Cells; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors; D044005:Tetrahydroisoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047131:Xestospongia / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D007546:Isoquinolines; D061988:Proteasome Inhibitors; D044005:Tetrahydroisoquinolines; C036617:salsolinol; D046988:Proteasome Endopeptidase Complex