title: Psychosocial impact of cutaneous toxicities associated with epidermal growth factor receptor-inhibitor treatment.
abstract: Epidermal growth factor receptor inhibitors (EGFRIs) are an increasingly important class of anticancer agents. Cutaneous toxicities, the most common adverse effects of EGFRI therapy, require dose modification or treatment cessation when moderate or severe and may compromise treatment compliance. To date, assessment has focused on physical symptoms associated with cutaneous toxicities; however, the psychosocial impact of those effects requires greater consideration. This article reviews current knowledge of assessment of cutaneous toxicities and identifies gaps in evidence, with particular focus on the psychosocial impact of cutaneous toxicities. Promising new assessment tools and approaches including the use of electronic patient-reported outcome measures are discussed, as well as implications for research in evaluating psychosocial interventions.
authors.affiliation: Cancer Institute of New South Wales, Sydney Nursing School, University of Sydney, Australia. kate.white@sydney.edu.au
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: White
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Roydhouse
authors.forename: Kathleen
authors.initials: K
authors.lastname: Scott
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000523:psychology; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000139:chemically induced* / Q000523:psychology*
chemical_list: D000970:Antineoplastic Agents; D066246:ErbB Receptors