title: Stiff-person syndrome: a case report and review of the literature.
abstract: We report a case of stiff-person syndrome associated with several autoimmune diseases. A 49-year-old male with type 1 diabetes presented with a 6-month history of muscle rigidity and spasms of his upper and lower extremities. Anti-glutamic acid decarboxylase 65 antibody was elevated at 609 nmol/L. Electromyography revealed continuous motor unit activity in agonist and antagonist muscles. He responded favorably to diazepam, baclofen, and intravenous immunoglobulin infusions. This case report describes stiff-person syndrome in association with pernicious anemia and diabetes mellitus. A review of the literature discusses the diagnosis and treatment of this rare entity.
authors.affiliation: Department of Internal Medicine, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, 4800 Alberta Ave, El Paso, TX 79905, USA. steveoge76@yahoo.com
authors.forename: Steve
authors.initials: S
authors.lastname: Egwuonwu
authors.forename: Fernando
authors.initials: F
authors.lastname: Chedebeau
mesh_terms: D000752:Anemia, Pernicious / Q000150:complications; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001418:Baclofen / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003937:Diagnosis, Differential; D003975:Diazepam / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004576:Electromyography; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D016750:Stiff-Person Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D014151:Anti-Anxiety Agents; D016756:Immunoglobulins, Intravenous; D009125:Muscle Relaxants, Central; D001418:Baclofen; D003975:Diazepam