title: Hormonal status in protracted critical illness and in-hospital mortality.
abstract: BACKGROUND
  The aim of this study was to determine the relationship between hormonal status and mortality in patients with protracted critical illness.
  
  
  METHODS
  We conducted a prospective observational study in four medical and surgical intensive care units (ICUs). ICU patients who regained consciousness after 7 days of mechanical ventilation were included. Plasma levels of insulin-like growth factor 1 (IGF-1), prolactin, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS) and cortisol were measured on the first day patients were awake and cooperative (day 1). Mean blood glucose from admission to day 1 was calculated.
  
  
  RESULTS
  We studied 102 patients: 65 men and 37 women (29 of the women were postmenopausal). Twenty-four patients (24%) died in the hospital. The IGF-1 levels were higher and the cortisol levels were lower in survivors. Mean blood glucose was lower in women who survived, and DHEA and DHEAS were higher in men who survived.
  
  
  CONCLUSIONS
  These results suggest that, on the basis of sex, some endocrine or metabolic markers measured in the postacute phase of critical illness might have a prognostic value.
authors.affiliation: Department of Intensive Care Medicine, AP-HP, Raymond Poincaré Hospital, University Versailles Saint-Quentin en Yvelines, 104 bd Raymond Poincaré, Garches F-92380, France. tarek.sharshar@rpc.aphp.fr
authors.forename: Tarek
authors.initials: T
authors.lastname: Sharshar
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bastuji-Garin
authors.forename: Andrea
authors.initials: A
authors.lastname: Polito
authors.forename: Bernard
authors.initials: B
authors.lastname: De Jonghe
authors.forename: Robert D
authors.initials: RD
authors.lastname: Stevens
authors.forename: Virginie
authors.initials: V
authors.lastname: Maxime
authors.forename: Pablo
authors.initials: P
authors.lastname: Rodriguez
authors.forename: Charles
authors.initials: C
authors.lastname: Cerf
authors.forename: Hervé
authors.initials: H
authors.lastname: Outin
authors.forename: Philippe
authors.initials: P
authors.lastname: Touraine
authors.forename: Kathleen
authors.initials: K
authors.lastname: Laborde
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016638:Critical Illness; D003687:Dehydroepiandrosterone / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012737:Sex Factors; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D007334:Insulin-Like Growth Factor I; D006854:Hydrocortisone