title: Facile ring-opening of azabicyclic [3.1.0]- and [4.1.0]aminocyclopropanes to afford 3-piperidinone and 3-azepinone.
abstract: Azabicyclic [3.1.0] and [4.1.0] Kulinkovich products underwent a facile reduction/fragmentation to afford a variety of 3-piperidinones and 3-azepinones, respectively, in the presence of catalytic palladium on carbon and formic acid in an atmosphere of hydrogen.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Jisun
authors.initials: J
authors.lastname: Lee
authors.forename: Simon
authors.initials: S
authors.lastname: Berritt
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Prier
authors.forename: Madeleine M
authors.initials: MM
authors.lastname: Joullié
mesh_terms: D053961:Azabicyclo Compounds / Q000737:chemistry*; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003521:Cyclopropanes / Q000737:chemistry*; D005561:Formates / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D053961:Azabicyclo Compounds; D001381:Azepines; D003521:Cyclopropanes; D005561:Formates; D010880:Piperidines; C030544:formic acid; D010165:Palladium; D002244:Carbon; D006859:Hydrogen