title: Investigating mitochondrial dysfunction to increase drug safety in the pharmaceutical industry.
abstract: Drug-induced mitochondrial dysfunction is a contributor to both late-stage compound attrition and post-market drug withdrawals. This review outlines the mechanisms which lead to drug-induced mitochondrial dysfunction and discusses the tremendous advances that have been made in the development of in vitro methods to identify mitochondrial impairment. Potentially useful animal models and in vivo methods to detect drug-induced mitochondrial impairment are also discussed.
authors.affiliation: Compound Safety Prediction, Pfizer Global R&D, Groton, CT 06340, USA.
authors.forename: Sashi
authors.initials: S
authors.lastname: Nadanaciva
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Will
mesh_terms: D000818:Animals; D015195:Drug Design; D004345:Drug Industry / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D028361:Mitochondrial Diseases / Q000139:chemically induced*; D023421:Models, Animal; D018675:Toxicity Tests / Q000379:methods