title: [The role of interleukin-6 and C-reactive protein in gastric cancer].
abstract: It has been suggested that interleukin-6 (IL-6) and C-reactive protein (CRP) play a potential role in the pathogenesis and growth of malignancies. CRP is produced by hepatocytes in response to inflammatory cytokines, especially IL-6. Production of IL-6 by gastric cancer cell lines has been reported. This cytokine may also act in a paracrine and autocrine fashion in tumor cells. Elevated concentrations of IL-6 and CRP were detected in the blood of patients with colorectal, lung, ovarian and gastric cancer. It has been shown that IL-6 and CRP levels correlated with clinicopathological features of gastric cancer, such as: tumor stage, depth of tumor invasion and the presence of lymph node metastasis. Some clinical investigations have suggested the potential significance of IL-6 as prognostic factor for the survival of gastric cancer patients.
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, Poland. marta.lukaszewicz-zajac@umwb.edu.pl
authors.forename: Marta
authors.initials: M
authors.lastname: Łukaszewicz-Zajac
authors.forename: Barbara
authors.initials: B
authors.lastname: Mroczko
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000378:metabolism; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness / Q000175:diagnosis / Q000503:physiopathology; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D015850:Interleukin-6; D002097:C-Reactive Protein