title: Diffuse hepatic and splenic uptake of Tc-99m methylene diphosphonate on bone scintigraphy after intravenous administration of gadolinium-containing MRI contrast.
abstract: Three patients with known lung cancer came on different days to our department to have a bone scan to evaluate possible osseous metastatic disease. The bone scan images showed increased Tc-99m methylene diphosphonate (Tc-99m MDP) activity in the liver and to a lesser degree in the spleen, whereas bone scan images from other patients on the same days showed no abnormal activity in the liver or spleen. On the same day, shortly before the bone scan, all 3 patients had a magnetic resonance imaging scan with an intravenous injection of Magnevist (Gadolinium-DTPA), which was not previously known to cause an altered Tc-99m MDP distribution. In the follow-up bone scans performed within 1 week of the initial bone scintigraphy, images from none of these 3 patients showed abnormal liver or spleen activity. The findings indicated that the increased Tc-99m MDP activity in the liver and spleen in the early studies was indeed an effect of Gadolinium-containing magnetic resonance imaging contrast. This effect was further confirmed by an animal experiment.
authors.affiliation: Department of Nuclear Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Dongcheng District, Beijing, People's Republic of China.
authors.forename: Ximin
authors.initials: X
authors.lastname: Shi
authors.forename: Hongli
authors.initials: H
authors.lastname: Jing
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhuang
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Jin
authors.forename: Fang
authors.initials: F
authors.lastname: Li
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging*; D013669:Technetium Tc 99m Medronate
chemical_list: D003287:Contrast Media; D005682:Gadolinium; D013669:Technetium Tc 99m Medronate