title: Melampomagnolide B: a new antileukemic sesquiterpene.
abstract: Melampomagnolide B has been identified as a new antileukemic sesquiterpene. A biotin-conjugated derivative of melampomagnolide B was designed and synthesized in order to elucidate its mechanism of action. A study of the biochemical interactions of the biotin probe suggests that melampomagnolide B derives its remarkable selectivity for leukemic cells over normal hematopoietic cells from its unique ability to exploit biochemical differences between the two cell types.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
authors.forename: Shama
authors.initials: S
authors.lastname: Nasim
authors.forename: ShanShan
authors.initials: S
authors.lastname: Pei
authors.forename: Fred K
authors.initials: FK
authors.lastname: Hagen
authors.forename: Craig T
authors.initials: CT
authors.lastname: Jordan
authors.forename: Peter A
authors.initials: PA
authors.lastname: Crooks
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C558241:melampomagnolide B