title: Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans.
abstract: An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.
authors.affiliation: Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America. kyk@bcm.edu
authors.forename: Katherine Y
authors.initials: KY
authors.lastname: King
authors.forename: Justin D
authors.initials: JD
authors.lastname: Lew
authors.forename: Ngan P
authors.initials: NP
authors.lastname: Ha
authors.forename: Jeffery S
authors.initials: JS
authors.lastname: Lin
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Edward A
authors.initials: EA
authors.lastname: Graviss
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Goodell
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D003424:Crohn Disease / Q000235:genetics; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000502:physiology; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D014376:Tuberculosis / Q000208:ethnology* / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers; D019204:GTP-Binding Proteins; C513539:IRGM protein, human