title: The correlation between thyrotropin and dyslipidemia in a population-based study.
abstract: This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.
authors.affiliation: Department of Endocrinology and Metabolism, First Hospital of China Medical University, Shengyang, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.forename: Beibei
authors.initials: B
authors.lastname: Wang
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.forename: Fengwei
authors.initials: F
authors.lastname: Jiang
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Teng
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Chen
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Lai
authors.forename: Jiani
authors.initials: J
authors.lastname: Wang
authors.forename: Haibo
authors.initials: H
authors.lastname: Xue
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
authors.forename: Chenyan
authors.initials: C
authors.lastname: Li
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.forename: Ningna
authors.initials: N
authors.lastname: Li
authors.forename: Jiashu
authors.initials: J
authors.lastname: Yu
authors.forename: Liangfeng
authors.initials: L
authors.lastname: Shi
authors.forename: Xin
authors.initials: X
authors.lastname: Hou
authors.forename: Qian
authors.initials: Q
authors.lastname: Xing
authors.forename: Xue
authors.initials: X
authors.lastname: Bai
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D013972:Thyrotropin; D002784:Cholesterol