title: Immunomodulatory action of monosulfated triterpene glycosides from the sea cucumber Cucumaria okhotensis: stimulation of activity of mouse peritoneal macrophages.
abstract: Six monosulfated triterpene glycosides, frondoside A1 (1), okhotoside B1 (2), okhotoside A1-1 (3), frondoside A (4), okhotoside A2-1 (5) and cucumarioside A2-5 (6), isolated from Cucumaria okhotensis Levin et Stepanov, stimulate spreading and lysosomal activity of mouse macrophages and ROS-formation in the macrophages. The highest macrophage spreading and stimulation of their lysosomal activity was induced by glycosides 1, 4 and 6. All glycosides similarly stimulate ROS formation in macrophages, but glycoside 2 caused minimal stimulation.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Vladivostok 690022, Russian Federation.
authors.forename: Dmitry L
authors.initials: DL
authors.lastname: Aminin
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Silchenko
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Avilov
authors.forename: Vadim G
authors.initials: VG
authors.lastname: Stepanov
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Kalinin
mesh_terms: D000818:Animals; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D007155:Immunologic Factors / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D017382:Reactive Oxygen Species / Q000378:metabolism; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D007155:Immunologic Factors; D017382:Reactive Oxygen Species; D014315:Triterpenes