title: Carbon-bonded silver nanoparticles: alkyne-functionalized ligands for SERS imaging of mammalian cells.
abstract: Silver nanoparticles bonded to terminal alkynes form stable particles in aqueous solution, produce strong SERS signals for molecular imaging that arise from the carbon-metal bond, and expand the scope of molecules that can be used to stably functionalize plasmonic particles for mammalian cell imaging applications. β-Lactams represent a class of biologically important molecules that can be adapted to SERS studies in this manner.
authors.affiliation: Steacie Institute for Molecular Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, K1A 0R6, Canada.
authors.forename: David C
authors.initials: DC
authors.lastname: Kennedy
authors.forename: Craig S
authors.initials: CS
authors.lastname: McKay
authors.forename: Li-lin
authors.initials: LL
authors.lastname: Tay
authors.forename: Yanouchka
authors.initials: Y
authors.lastname: Rouleau
authors.forename: John P
authors.initials: JP
authors.lastname: Pezacki
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000032:analysis; D053768:Metal Nanoparticles / Q000737:chemistry*; D062793:Occludin; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D047090:beta-Lactams / Q000737:chemistry
chemical_list: D000480:Alkynes; D008024:Ligands; D008565:Membrane Proteins; C568985:OCLN protein, human; D062793:Occludin; D047090:beta-Lactams; D012834:Silver; D002244:Carbon