title: Primary position upbeat nystagmus reversed with carbamazepine.
abstract: A 16-year old girl presented with primary position upbeat nystagmus (PPUN). MRI showed a small lesion at the perihypoglossal nuclei of the dorsal medulla oblongata. The case was diagnosed as a demyelinating disease for its response to prednisone, and the nystagmus decreased after administration of carbamazepine. Primary position upbeat nystagmus might be caused by an abnormal firing of neurons in the nuclei resulting in a tonic imbalance of vertical gaze. Also this is the first report to confirm the attenuation of PPUN by carbamazepine.
authors.affiliation: Japanese Red Cross Medical Center, Department of Neurology, 4-1-22 Hiroo Shibuya-ku, Tokyo 150, JapanYokohama Rosai Hospital, Department of Neurology, 211 Kozukue-cho, Kohoku-ku, Yokohama, Kanagawa 222, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iwata
authors.forename: F
authors.initials: F
authors.lastname: Takao
authors.forename: M
authors.initials: M
authors.lastname: Kunimoto
authors.forename: K
authors.initials: K
authors.lastname: Inoue