title: Asymmetric total synthesis of danicalipin A and evaluation of biological activity.
abstract: Asymmetric total synthesis of danicalipin A was achieved. The synthesis was characterized by diastereoselective introduction of chlorine atoms. Biological activities with synthetic danicalipin A, its enantiomer, and racemate were also evaluated toward brine shrimp. Both enantiomers of danicalipin A showed almost the same activity.
authors.affiliation: Division of Environmental Materials Science, Graduate School of Environmental Science, Hokkaido University, Sapporo, Japan. umezawa@ees.hokudai.ac.jp
authors.forename: Taiki
authors.initials: T
authors.lastname: Umezawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shibata
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kaneko
authors.forename: Tatsufumi
authors.initials: T
authors.lastname: Okino
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D044663:Ochromonas / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008055:Lipids; C557671:danicalipin A