title: Clinical-radiographic and histological evaluation of two hydroxyapatites in human extraction sockets: a pilot study.
abstract: After tooth extraction the healing process involves bone resorption and soft tissue contraction, events that can compromise the ideal implant placement with functional and aesthetic limitations. Following tooth extraction, a socket preservation technique can limit bone resorption. This study evaluated two different types of hydroxyapatite (HA) grafting materials placed into fresh extraction sockets, 6 months after tooth extraction, histologically, clinically and radiographically. Ten extraction sockets from 10 patients were divided in two groups: 5 sockets received a biomimetic HA and 5 received nanocrystalline HA. After 6 months, before implant placement, samples from the grafted area were harvested and evaluated clinically, radiographically and histologically. The percentages of bone, osteoid areas and residual material in the two groups were not statistically different. All samples showed great variability with extensive bone formation and total material resorption or amounts of osteoid tissue that filled the spaces between the residual material particles. The authors did not find any differences between biomimetic and nanocrystalline HA and assume that, within the limits of this study, both these materials could be applied into fresh extraction sockets to limit bone resorption. A control material and a much larger sample size are needed to confirm these findings.
authors.affiliation: Department of Odontostomatological, Orthodontic and Surgical Sciences, Second University of Naples, Via De Crecchio 6, Naples, Italy. vchecchi@hotmail.com
authors.forename: V
authors.initials: V
authors.lastname: Checchi
authors.forename: L
authors.initials: L
authors.lastname: Savarino
authors.forename: M
authors.initials: M
authors.lastname: Montevecchi
authors.forename: P
authors.initials: P
authors.lastname: Felice
authors.forename: L
authors.initials: L
authors.lastname: Checchi
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D001672:Biocompatible Materials / Q000627:therapeutic use*; D040761:Biomimetic Materials / Q000627:therapeutic use; D015519:Bone Density / Q000502:physiology; D001857:Bone Matrix / Q000000981:diagnostic imaging / Q000473:pathology; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000517:prevention & control; D018786:Bone Substitutes / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D053758:Nanoparticles / Q000627:therapeutic use; D010012:Osteogenesis / Q000502:physiology; D010865:Pilot Projects; D011859:Radiography; D014081:Tooth Extraction; D020390:Tooth Socket / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D017886:Durapatite