title: Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana.
abstract: The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 microg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-beta-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 microg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 microg/mL, respectively. A structure-activity relationship is discussed.
authors.affiliation: Plants for Human Health Institute, Department of Food Bioprocessing & Nutrition Sciences, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA.
authors.forename: Mary H
authors.initials: MH
authors.lastname: Grace
authors.forename: Carmen
authors.initials: C
authors.lastname: Lategan
authors.forename: Flaubert
authors.initials: F
authors.lastname: Mbeunkui
authors.forename: Rocky
authors.initials: R
authors.lastname: Graziose
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Smith
authors.forename: Ilya
authors.initials: I
authors.lastname: Raskin
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Lila
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D016466:CHO Cells; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D019684:Magnoliopsida / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane