title: [Obtention of an antivenom against Phoneutria nigriventer (arachnida; ctenidae) venom].
abstract: Envenomation by spiders of the genus Phoneutria ("banana spider") may be lethal, especially in children. The only available specific treatment is the use of antivenom, which is produced by only one laboratory in the world. In this study we report the development of an equine F (ab')2 experimental antivenom raised against the venom of Phoneutria nigriventer. The antivenom neutralized the venom of spiders from different regions of Argentina (Misiones and Jujuy), the development of envenomation symptoms in experimental animals was totally inhibited. These results show that local production of this type of antivenom is possible. Independence of production is important since international acquisition is always conditioned by the availability of stock surplus from the sole producer.
authors.affiliation: Área Investigación y Desarrollo/Serpentario, ANLIS Dr. Carlos G. Malbrán, Ministerio de Salud de la Nación, Argentina. aderoodt@gmail.com
authors.forename: Adolfo R
authors.initials: AR
authors.lastname: de Roodt
authors.forename: Luis R
authors.initials: LR
authors.lastname: Gutiérrez
authors.forename: Roberto
authors.initials: R
authors.lastname: Rufino Caro
authors.forename: Néstor R
authors.initials: NR
authors.lastname: Lago
authors.forename: José L
authors.initials: JL
authors.lastname: Montenegro
mesh_terms: D000818:Animals; D000997:Antivenins / Q000096:biosynthesis*; D013111:Spider Venoms / Q000037:antagonists & inhibitors*
chemical_list: D000997:Antivenins; D013111:Spider Venoms