title: [Neonatal seizures, buprenorphine abstinence syndrome, and substitutive treatment with morphine].
abstract: We report the case of a hypotrophic twin who presented neonatal abstinence syndrome to buprenorphine and developed neonatal seizures when the substitutive treatment by morphine was stopped. The other eutrophic twin did not develop withdrawal symptoms. This case demonstrates the unpredictable nature of transplacental transfer of buprenorphine. It also shows that neonatal abstinence syndrome can be potentially severe and that morphine treatment is not without risk.
authors.affiliation: Service de néonatologie, hôpital Armand-Trousseau, AP-HP, faculté de médecine, université Pierre-et-Marie-Curie, 26, avenue du Dr-Arnold-Netter, 75571 Paris cedex 12, France. sonia.dahan@trs.aphp.fr
authors.forename: S
authors.initials: S
authors.lastname: Dahan
authors.forename: E
authors.initials: E
authors.lastname: Elefant
authors.forename: I
authors.initials: I
authors.lastname: Girard
authors.forename: B
authors.initials: B
authors.lastname: Azcona
authors.forename: V
authors.initials: V
authors.lastname: Champion
authors.forename: D
authors.initials: D
authors.lastname: Mitanchez
mesh_terms: D002047:Buprenorphine / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D007231:Infant, Newborn; D009020:Morphine / Q000627:therapeutic use; D009294:Narcotics / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D009357:Neonatal Abstinence Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D012640:Seizures / Q000209:etiology*; D014427:Twins
chemical_list: D009294:Narcotics; D002047:Buprenorphine; D009020:Morphine