title: Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate.
abstract: Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP.
authors.affiliation: Chemical and Environmental Engineering Department, University of California, Riverside, CA 92521, USA.
authors.forename: Basanta K
authors.initials: BK
authors.lastname: Das
authors.forename: Chaker
authors.initials: C
authors.lastname: Tlili
authors.forename: Sushmee
authors.initials: S
authors.lastname: Badhulika
authors.forename: Lakshmi N
authors.initials: LN
authors.lastname: Cella
authors.forename: Wilfred
authors.initials: W
authors.lastname: Chen
authors.forename: Ashok
authors.initials: A
authors.lastname: Mulchandani
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis*; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015374:Biosensing Techniques / Q000379:methods*; D036103:Nanotechnology; D037742:Nanotubes, Carbon / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D052157:Aptamers, Nucleotide; D037742:Nanotubes, Carbon; D000255:Adenosine Triphosphate