title: Multiplying recipients paired with oocyte donors optimizes the use of donated oocytes.
abstract: OBJECTIVE
  To review donor-egg assisted reproductive technology (ART) activity using young fertile donors (<37 years of age) paired with multiple recipients.
  
  
  METHODS
  Age-matched cohort study.
  
  
  METHODS
  Tertiary ART center at Cochin Hospital, Paris.
  
  
  METHODS
  A total of 125 oocyte donors and 361 age-matched control subjects. Donated oocytes were attributed to 163 different recipients undertaking 258 transfer cycles.
  
  
  METHODS
  Donor-egg and regular ART.
  
  
  METHODS
  Controlled ovarian hyperstimulation (COH) outcome-oocytes provided-was compared in donors and control subjects. Clinical pregnancy (cPR), ongoing pregnancy (oPR), and implantation (IR) rates per transfer in recipients were compared with age-matched controls. IRs were analyzed in the various recipients as a function of the number of oocytes harvested.
  
  
  RESULTS
  COH outcome was similar in donors and control subjects. cPR (37.5%), oPR (28.4%), and IR (24.4%) were slightly but significantly lower in donor-egg recipients compared with control subjects (44.9%, 37.4%, and 31.8%, respectively). More embryos (average +2.06) were transferred fresh and fewer frozen. In recipients, IRs were independent from the number of oocytes received in the donor.
  
  
  CONCLUSIONS
  Multiplying recipients paired with oocyte donors slightly lowered per-transfer outcome, but enabled more (average +2.06) embryos to be transferred fresh.
authors.affiliation: Service de Gynécologie Obstétrique II, Hôpital St Vincent de Paul, 82 Bd Denfert-Rocherau, 75014 Paris, France. ddeziegler@orange.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: de Ziegler
authors.forename: Jacques
authors.initials: J
authors.lastname: de Mouzon
authors.forename: Patricia
authors.initials: P
authors.lastname: Fauque
authors.forename: Marianna
authors.initials: M
authors.lastname: Zanette
authors.forename: Anne
authors.initials: A
authors.lastname: Marszałek
authors.forename: Valérie
authors.initials: V
authors.lastname: Blanchet
authors.forename: Céline Chalas
authors.initials: CC
authors.lastname: Boissonas
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Wolf
authors.forename: Charles
authors.initials: C
authors.lastname: Chapron
mesh_terms: D000328:Adult; D002138:Calibration; D016022:Case-Control Studies; D015331:Cohort Studies; D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D006801:Humans; D018587:Oocyte Donation / Q000379:methods* / Q000592:standards*; D009865:Oocytes / Q000166:cytology* / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D014019:Tissue Donors / Q000706:statistics & numerical data; D014180:Transplantation / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome