title: Leber's hereditary optic neuropathy precipitated by tadalafil use for erectile dysfunction.
abstract: Leber's hereditary optic neuropathy (LHON) is an inherited condition leading to bilateral centrocaecal scotoma. Phosphodiesterase type-5 (PDE5) inhibitors such as tadalafil are widely used for male erectile dysfunction. We present a case of a middle-aged male whose LHON presented acutely following tadalafil use. It is postulated that this is due to alteration in the optic nerve head perfusion.
authors.affiliation: Raigmore Hospital, Old Perth Road, Inverness, UK. kurtsc01@yahoo.co.uk
authors.forename: Kurt Spiteri
authors.initials: KS
authors.lastname: Cornish
authors.forename: Christopher
authors.initials: C
authors.lastname: Barras
mesh_terms: D002243:Carbolines / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D029242:Optic Atrophy, Hereditary, Leber / Q000139:chemically induced* / Q000175:diagnosis; D058986:Phosphodiesterase 5 Inhibitors / Q000009:adverse effects*; D000068581:Tadalafil; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields
chemical_list: D002243:Carbolines; D058986:Phosphodiesterase 5 Inhibitors; D000068581:Tadalafil