title: The Aurora A F31I polymorphism is not a risk factor for glioblastoma.
abstract: BACKGROUND
  The Aurora A F31I polymorphism has been linked to increased risk of several human cancers. Glioblastoma (GBM) is the most malignant glioma as well as the most frequent adult primary brain tumor.
  
  
  METHODS
  In this case-control study we investigated the association of Aurora A F31I polymorphism with GBM risk.
  
  
  RESULTS
  A total of 96 histologically confirmed patients with GBM and 93 health individuals were analyzed for the Aurora A F31I single nucleotide polymorphism. The single nucleotide polymorphism data were compared and risks associated with individual genotypes and allelotypes were evaluated in terms of odd ratios.
  
  
  CONCLUSIONS
  The data obtained from this case-control study demonstrates that the Aurora A F31I polymorphism is not a significant risk for GBMs.
authors.affiliation: The Brain Tumor and Neuro-Oncology Center, Department of Neurosurgery and the Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA. kapila_nava@yahoo.com
authors.forename: Kapila S
authors.initials: KS
authors.lastname: Navaratne
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Weil
mesh_terms: D000483:Alleles; D064127:Aurora Kinases; D001932:Brain Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012016:Reference Values
chemical_list: D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases