title: Indirect modulation of the intracellular c-Di-GMP level in Shewanella oneidensis MR-1 by MxdA.
abstract: The GGDEF domain protein MxdA, which is important for biofilm formation in Shewanella oneidensis MR-1, was hypothesized to possess diguanylate cyclase activity. Here, we demonstrate that while MxdA controls the cellular level of c-di-GMP in S. oneidensis, it modulates the c-di-GMP pool indirectly.
authors.affiliation: Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5429, USA.
authors.forename: Shauna
authors.initials: S
authors.lastname: Rakshe
authors.forename: Maija
authors.initials: M
authors.lastname: Leff
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Spormann
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D019761:Phosphorus-Oxygen Lyases / Q000235:genetics / Q000378:metabolism; D020592:Shewanella / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C062025:bis(3',5')-cyclic diguanylic acid; D019761:Phosphorus-Oxygen Lyases; C060720:diguanylate cyclase; D006152:Cyclic GMP