title: Role of TLR2-dependent inflammation in metastatic progression.
abstract: Inflammation is a part of the host defense system, which provides protection against invading pathogens. However, it has become increasingly clear that inflammation can be evoked by endogenous mediators through Toll-like receptors (TLRs) to enhance tumor progression and metastasis. Here, we discuss the roles of TLR-mediated inflammation in tumor progression and the mechanisms through which it accomplishes this pathogenic function.
authors.affiliation: Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, La Jolla, California, USA.
authors.forename: Sunhwa
authors.initials: S
authors.lastname: Kim
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D051195:Toll-Like Receptor 2 / Q000502:physiology*
chemical_list: D018836:Inflammation Mediators; D051195:Toll-Like Receptor 2