title: Molecular epidemiology of foot-and-mouth disease virus serotypes A and O with emphasis on Korean isolates: temporal and spatial dynamics.
abstract: We determined complete 1D gene sequences for one serotype A and seven additional serotype O Korean foot-and-mouth disease viruses (FMDV) and then analyzed them together with published sequences for 180 type A and 300 type O isolates from throughout the world using a Bayesian coalescent approach. Here, Korean serotype A virus was linked with those from Laos. Korean serotype O viruses were divided into three clades and were closely related to isolates from Japan, Thailand, the UK, France, Ireland, South Africa, and Singapore, as well as Laos. There was no apparent correlation between time, country, or host species and the evolution of global FMDVs. Additionally, our results showed that purifying selection acts on the overall 1D sequences and there was no evidence of recombination among the FMDV sequences. The evolutionary rates were 5.77 × 10(-3) substitutions/site/year for serotype A and 4.81 × 10(-3) substitutions/site/year for serotype O. Serotype A viruses diverged approximately 110 years ago, while serotype O isolates segregated approximately 127 years before the present. In both serotype isolates, the effective number of infections remained constant until the late 1990 s, after which the virus population size underwent a rapid, sharp decline until the present.
authors.affiliation: Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University, Republic of Korea.
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: Yoon
authors.forename: Kwang-Nyeong
authors.initials: KN
authors.lastname: Lee
authors.forename: Jong-Hyeon
authors.initials: JH
authors.lastname: Park
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000821:virology*; D016000:Cluster Analysis; D019143:Evolution, Molecular; D005536:Foot-and-Mouth Disease / Q000453:epidemiology / Q000821:virology*; D029544:Foot-and-Mouth Disease Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D005838:Genotype; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D058974:Phylogeography; D056910:Republic of Korea / Q000453:epidemiology; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*; D013997:Time Factors
chemical_list: D036022:Capsid Proteins; C442501:VP1 protein, Foot-and-mouth disease virus