title: Update on stem cell therapy for cerebral palsy.
abstract: BACKGROUND
  Due to the publicity about stem cell transplantation for the treatment of cerebral palsy, many families seek information on treatment, and many travel overseas for cell transplantation. Even so, there is little scientific confirmation of benefit, and therefore existing knowledge in the field must be summarized.
  
  
  METHODS
  This paper addresses the clinical protocols examining the problem, types of stem cells available for transplant, experimental models used to test the benefit of the cells, possible mechanisms of action, potential complications of cell treatment and what is needed in the field to help accelerate cell-based therapies.
  
  
  CONCLUSIONS
  While stem cells may be beneficial in acute injuries of the CNS the biology of stem cells is not well enough understood in chronic injuries or disorders such as cerebral palsy. More work is required at the basic level of stem cell biology, in the development of animal models, and finally in well-conceived clinical trials.
authors.affiliation: Medical College of Georgia, Neurology, Augusta, GA 30912, USA. JCARROLL@mail.mcg.edu
authors.forename: James E
authors.initials: JE
authors.lastname: Carroll
authors.forename: Robert W
authors.initials: RW
authors.lastname: Mays
mesh_terms: D000818:Animals; D002547:Cerebral Palsy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D009416:Nerve Regeneration; D009474:Neurons / Q000473:pathology / Q000637:transplantation*; D020127:Recovery of Function; D033581:Stem Cell Transplantation / Q000009:adverse effects; D016896:Treatment Outcome