title: Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets.
abstract: The frequency of opportunistic fungal infection has increased drastically, mainly in patients who are immunocompromised due to organ transplant, leukemia or HIV infection. In spite of this, only a few classes of drugs with a limited array of targets, are available for antifungal therapy. Therefore, more specific and less toxic drugs with new molecular targets is desirable for the treatment of fungal infections. In this context, searching for differences between mitochondrial mammalian hosts and fungi in the classical and alternative components of the mitochondrial respiratory chain may provide new potential therapeutic targets for this purpose.
authors.affiliation: Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Vicente de Paulo
authors.initials: Vde P
authors.lastname: Martins
authors.forename: Taisa Magnani
authors.initials: TM
authors.lastname: Dinamarco
authors.forename: Carlos
authors.initials: C
authors.lastname: Curti
authors.forename: Sérgio Akira
authors.initials: SA
authors.lastname: Uyemura
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D045304:Cytochromes c / Q000378:metabolism*; D055808:Drug Discovery; D004579:Electron Transport / Q000502:physiology; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism*; D005658:Fungi / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism; D009181:Mycoses / Q000188:drug therapy*; D010088:Oxidoreductases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D000071256:Uncoupling Protein 1
chemical_list: D045222:Electron Transport Chain Complex Proteins; D007473:Ion Channels; D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species; D000071256:Uncoupling Protein 1; D000255:Adenosine Triphosphate; D045304:Cytochromes c; D010088:Oxidoreductases; C432586:ubiquinol oxidase