title: Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells.
abstract: Immune-neuronal interactions contribute to neuropathic pain. Thus, immune-competent cells such as microglia may provide targets for pain relief, as may infiltrating lymphocytes. We evaluated the nature of the lymphocyte response in the spinal cord in association with the maintenance of neuropathic allodynia. We assessed T cell contribution to pain processing by targeting these cells with Glatiramer acetate (GA) which when administered systemically reversed neuropathic allodynia, inhibited microglia response and increased IL-10 and IL-4 expressing T cells in neuropathic dorsal horns. These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention.
authors.affiliation: Wolfson Centre for Age Related Disease, Kings College London, London, UK.
authors.forename: Tanya
authors.initials: T
authors.lastname: Leger
authors.forename: John
authors.initials: J
authors.lastname: Grist
authors.forename: Fulvio
authors.initials: F
authors.lastname: D'Acquisto
authors.forename: Anna K
authors.initials: AK
authors.lastname: Clark
authors.forename: Marzia
authors.initials: M
authors.lastname: Malcangio
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects*; D000704:Analysis of Variance; D000818:Animals; D017252:CD3 Complex / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D005434:Flow Cytometry / Q000379:methods; D000068717:Glatiramer Acetate; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016753:Interleukin-10 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D008297:Male; D008840:Microfilament Proteins; D017628:Microglia / Q000187:drug effects / Q000276:immunology; D017288:Pain Threshold / Q000187:drug effects; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012585:Sciatica / Q000150:complications / Q000188:drug therapy; D013116:Spinal Cord / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: C100745:Aif1 protein, rat; D017252:CD3 Complex; D015704:CD4 Antigens; D002135:Calcium-Binding Proteins; D007166:Immunosuppressive Agents; D008840:Microfilament Proteins; D010455:Peptides; D016753:Interleukin-10; D015847:Interleukin-4; D000068717:Glatiramer Acetate