title: Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption?
abstract: This account of recent work presented at the 4th International Symposium on Alcohol Pancreatitis and Cirrhosis reports animal studies aimed at determining the role of the "acetaldehyde burst," generated shortly upon ethanol intake, as the mechanism of protection against alcoholism conferred by the ADH1B*2 polymorphism. Literature studies discussed suggest an additional role of the acetaldehyde burst on the paradoxical (hormesis) protection of the ADH1B*2 polymorphism against esophageal cancers in alcoholics.
authors.affiliation: Department of Pharmacological and Toxicological Chemistry, University of Chile, Santiago, Chile. yisrael@uchile.cl
authors.forename: Yedy
authors.initials: Y
authors.lastname: Israel
authors.forename: Mario
authors.initials: M
authors.lastname: Rivera-Meza
authors.forename: María Elena
authors.initials: ME
authors.lastname: Quintanilla
authors.forename: Amalia
authors.initials: A
authors.lastname: Sapag
authors.forename: Lutske
authors.initials: L
authors.lastname: Tampier
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism; D000426:Alcohol Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000517:prevention & control; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D016897:Respiratory Burst / Q000235:genetics*
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde