title: Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg).
abstract: Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of 8.5±3.5% of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
authors.affiliation: Department of Animal Biotechnology, College of Animal Bioscience & Technology, Konkuk University, Seoul 143-701, Korea.
authors.forename: Joonyong
authors.initials: J
authors.lastname: Noh
authors.forename: Wahn Soo
authors.initials: WS
authors.lastname: Choi
authors.forename: Geunwoong
authors.initials: G
authors.lastname: Noh
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Lee