title: Synthesis and biocompatibility of an experimental glass ionomer cement prepared by a non-hydrolytic sol-gel method.
abstract: The aims of this study were to demonstrate the synthesis of an experimental glass ionomer cement (GIC) by the non-hydrolytic sol-gel method and to evaluate its biocompatibility in comparison to a conventional glass ionomer cement (Vidrion R). Four polyethylene tubes containing the tested cements were implanted in the dorsal region of 15 rats, as follows: GI - experimental GIC and GII - conventional GIC. The external tube walls was considered the control group (CG). The rats were sacrificed 7, 21 and 42 days after implant placement for histopathological analysis. A four-point (I-IV) scoring system was used to graduate the inflammatory reaction. Regarding the experimental GIC sintherization, thermogravimetric and x-ray diffraction analysis demonstrated vitreous material formation at 110oC by the sol-gel method. For biocompatibility test, results showed a moderate chronic inflammatory reaction for GI (III), severe for GII (IV) and mild for CG (II) at 7 days. After 21 days, GI presented a mild reaction (II); GII, moderate (III) and CG, mild (II). At 42 days, GI showed a mild/absent inflammatory reaction (II to I), similar to GII (II to I). CG presented absence of chronic inflammatory reaction (I). It was concluded that the experimental GIC presented mild/absent tissue reaction after 42 days, being biocompatible when tested in the connective tissue of rats.
authors.affiliation: Department of Dental Materials and Prosthodontics, Ribeirão Preto Dental School, University of São Paulo, Ribeirão Preto, SP, Brazil.
authors.forename: Lucas da Fonseca Roberti
authors.initials: Lda F
authors.lastname: Garcia
authors.forename: Fernanda de Carvalho Panzeri
authors.initials: Fde C
authors.lastname: Pires-de-Souza
authors.forename: Juliana Mazzoneto
authors.initials: JM
authors.lastname: Teófilo
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cestari
authors.forename: Paulo Sergio
authors.initials: PS
authors.lastname: Calefi
authors.forename: Katia Jorge
authors.initials: KJ
authors.lastname: Ciuffi
authors.forename: Eduardo José
authors.initials: EJ
authors.lastname: Nassar
mesh_terms: D017607:Aluminum Compounds / Q000138:chemical synthesis; D000818:Animals; D001672:Biocompatible Materials; D003238:Connective Tissue / Q000187:drug effects*; D018360:Crystallography, X-Ray; D005459:Fluorides / Q000138:chemical synthesis; D005899:Glass Ionomer Cements / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006868:Hydrolysis; D008297:Male; D008422:Materials Testing; D044367:Phase Transition; D051381:Rats; D017655:Silicon Compounds / Q000138:chemical synthesis; D044366:Transition Temperature
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D005899:Glass Ionomer Cements; D017655:Silicon Compounds; C020328:fluoroaluminum silicate; D005459:Fluorides