title: Antioxidant flavanes from Livistona chinensis.
abstract: Three new flavanes and eight known flavonoids were isolated from the fruits of Livistona chinensis. The structure of the new flavanes were established as 2S,3S-3,5,7,3',5'-pentahydroxyflavane (1), 2R,3R-3,5,6,7,8,4'-hexahydroxyflavane (2) and 2R,3R-3,5,6,7,8,3',5'-heptahydroxyflavane (3), respectively, on the basis of chemical and spectroscopic data. The antiproliferative activity against four human tumor cell lines (HL-60, Mata, HepG2 and CNE-1) was evaluated. 1 had significantly antiproliferative effects against HL-60 and CNE-1 with the IC(50) of 0.2 ± 0.01 and 1.0 ± 0.1 μM, respectively, overpowering the reference compound in the assay (cisplatin). Most compounds also exhibited potent antioxidant activity.
authors.affiliation: College of Pharmacy, Wuhan University, Wuhan 430071, China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zeng
authors.forename: Qian
authors.initials: Q
authors.lastname: Qiu
authors.forename: Chenguang
authors.initials: C
authors.lastname: Jiang
authors.forename: Yuntiao
authors.initials: Y
authors.lastname: Jing
authors.forename: Guofu
authors.initials: G
authors.lastname: Qiu
authors.forename: Xiangjiu
authors.initials: X
authors.lastname: He
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D000975:Antioxidants / Q000032:analysis*; D028023:Arecaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure
chemical_list: C560389:2R,3R-3,5,6,7,8,3',5'-heptahydroxyflavane; C560388:2R,3R-3,5,6,7,8,4'-hexahydroxyflavane; C560387:2S,3S-3,5,7,3',5'-pentahydroxyflavane; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005419:Flavonoids