title: [Animal models for bone and joint disease. Mouse models develop spontaneous osteoarthritis].
abstract: Osteoarthritis (OA) is a major joint disorder that significantly decreases the quality of life of elderly. Animal models, especially mice, have contributed in studies on a number of diseases. Among mice develop OA spontaneously, genetically-modified and naturally mutated mice have been reported. STR/ort is a well recognized model, which pronounces natural onset OA. Here we introduce the several models possessed spontaneous OA with focusing the feature and utilization of STR/ort.
authors.affiliation: Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology (NCGG).
authors.forename: Ken
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Oue
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D000818:Animals; D064236:Cartilage Oligomeric Matrix Protein; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D064235:Matrilin Proteins; D051379:Mice; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D010003:Osteoarthritis / Q000235:genetics; D040641:Quantitative Trait Loci
chemical_list: D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; C577540:Matn1 protein, mouse; D064235:Matrilin Proteins; C577553:TSP5 protein, human