title: Synthesis, characterization and antifungal evaluation of 5-substituted-4-amino-1,2,4-triazole-3-thioesters.
abstract: A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2-thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazole-2-thioesters in the presence of hydrazine hydrate and absolute alcohol. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The synthesized compounds were evaluated for their in vitro antifungal activity. Some of the evaluated compounds possessed significant antifungal activity as compared to a terbinafine standard.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur-50603, Malaysia. flavonoids@hotmail.com
authors.forename: Aurangzeb
authors.initials: A
authors.lastname: Hasan
authors.forename: Noel Francis
authors.initials: NF
authors.lastname: Thomas
authors.forename: Shelly
authors.initials: S
authors.lastname: Gapil
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017550:Spectroscopy, Fourier Transform Infrared; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D004952:Esters; D014230:Triazoles; C533754:4-amino-1,2,4-triazole