title: Fiber based pathogen photoinactivating system.
abstract: A new fiber based instrument described, which can be inserted through the nose, mouth, or other means into the body, has the potential to: (a) detect and image infected areas inside the body; (b) deliver drugs only onto the infected areas inside and outside the human body; (c) remove the excess drugs; (d) use the same fiber for both imaging and illumination with high intensity light of wavelengths varying from deep UV to IR to induce photoreactions of the drug with the pathogen of the infected area. This compact system utilizes much smaller quantities of drugs and radiation dose than conventional methods, eliminates the need for intravenous injection, and greatly decreases the toxic effects of drugs and irradiation to the human body including swelling, inflammation, nausea, fever, and sunlight sensitivity that lasts for about 30 days.
authors.affiliation: Department of Physics, Shanghai Jiao Tong University, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Cesario
authors.forename: Peter M
authors.initials: PM
authors.lastname: Rentzepis
mesh_terms: D001419:Bacteria / Q000187:drug effects* / Q000528:radiation effects*; D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008027:Light; D050296:Microbial Viability / Q000187:drug effects / Q000528:radiation effects; D057054:Molecular Imaging / Q000295:instrumentation*; D055100:Optical Fibers; D010778:Photochemotherapy / Q000295:instrumentation*; D017319:Photosensitizing Agents / Q000494:pharmacology
chemical_list: D017319:Photosensitizing Agents