title: Controversies in the definition and treatment of idiopathic short stature (ISS).
abstract: The term idiopathic short stature (ISS) refers to short children with no identifiable disorder of the growth hormone (GH)/insulin like growth factor (IGF) axis and no other endocrine, genetic or organ system disorder. This heterogeneous group of short children without GH deficiency (GHD) includes children with constitutional delay of growth and puberty, familial short stature, or both, as well as those with subtle cartilage and bone dysplasias. In rare cases, ISS is due to IGF molecular abnormalities. In this review we tackle the major challenges in the definition and treatment of ISS.
authors.affiliation: Rina Balducci Center of Pediatric Endocrinology, Department of Public Health and Cell Biology, Tor Vergata University, Rome, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Pedicelli
authors.forename: Emanuela
authors.initials: E
authors.lastname: Peschiaroli
authors.forename: Enrica
authors.initials: E
authors.lastname: Violi
authors.forename: Stefano
authors.initials: S
authors.lastname: Cianfarani
mesh_terms: D000293:Adolescent; D047072:Aromatase Inhibitors / Q000627:therapeutic use; D001827:Body Height / Q000187:drug effects; D002648:Child; D004392:Dwarfism / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D004393:Dwarfism, Pituitary / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006130:Growth Disorders / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D019382:Human Growth Hormone / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D008297:Male; D045165:Testosterone Congeners / Q000627:therapeutic use
chemical_list: D047072:Aromatase Inhibitors; D045165:Testosterone Congeners; D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone