title: High frequency of PfCRT 76T in two Malian villages and its prevalence in severe relative to non-severe malaria.
abstract: We investigated PfCRT 76T mutation in severe and non-severe malaria in Southern Mali. One hundred and ninety three severe malaria cases were each matched against two non-severe malaria cases. Patients with G6PD deficiency and any known hemoglobin abnormality were excluded. PfCRT 76T was present in 60.8% (n=386) non-severe malaria cases and in 77.2% (n=193) severe malaria cases (p<0.0001). In children 5 years or younger, these proportions were 62.9% (n=294) vs. 73.5% (n=147), respectively (p<0.01). PfCRT 76T was therefore associated with malaria severity in this setting of Mali.
authors.affiliation: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali.
authors.forename: Mamadou
authors.initials: M
authors.lastname: Wélé
authors.forename: Abdoulaye A
authors.initials: AA
authors.lastname: Djimdé
authors.forename: Aldiouma
authors.initials: A
authors.lastname: Guindo
authors.forename: Abdoul H
authors.initials: AH
authors.lastname: Beavogui
authors.forename: Isaac Z
authors.initials: IZ
authors.lastname: Traoré
authors.forename: Aboubacar
authors.initials: A
authors.lastname: Sadou
authors.forename: Dackouo
authors.initials: D
authors.lastname: Blaise
authors.forename: Dapa A
authors.initials: DA
authors.lastname: Diallo
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Wellems
authors.forename: Ogobara K
authors.initials: OK
authors.lastname: Doumbo
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use; D016054:DNA, Protozoan / Q000032:analysis / Q000235:genetics; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D008297:Male; D008302:Mali / Q000453:epidemiology; D026901:Membrane Transport Proteins / Q000235:genetics*; D009154:Mutation; D010963:Plasmodium falciparum / Q000235:genetics* / Q000469:parasitology; D015995:Prevalence; D015800:Protozoan Proteins / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: D016054:DNA, Protozoan; D026901:Membrane Transport Proteins; C416369:PfCRT protein, Plasmodium falciparum; D015800:Protozoan Proteins; D002738:Chloroquine