title: Subcellular localization of RNA degrading proteins and protein complexes in prokaryotes.
abstract: The archaeal exosome is a prokaryotic protein complex with RNA processing and degrading activities. Recently it was shown that the exosome is localized at the periphery of the cell in the thermoacidophilic archaeon Sulfolobus solfataricus. This localization is most likely mediated by the archaeal DnaG protein and depends on (direct or indirect) hydrophobic interactions with the membrane. A localization of RNA degrading proteins and protein complexes was also demonstrated in several bacteria. In bacteria a subcellular localization was also shown for substrates of these proteins and protein complexes, i.e. chromosomally encoded mRNAs and a small RNA. Thus, despite the missing compartmentalization, a spatial organization of RNA processing and degradation exists in prokaryotic cells. Recent data suggest that the spatial organization contributes to the temporal regulation of these processes.
authors.affiliation: Institut für Mikrobiologie und Molekularbiologie, Justus-Liebig-Universität Giessen, Germany. Elena.Evguenieva-Hackenberg@mikro.bio.uni-giessen.de
authors.forename: Elena
authors.initials: E
authors.lastname: Evguenieva-Hackenberg
authors.forename: Verena
authors.initials: V
authors.lastname: Roppelt
authors.forename: Christian
authors.initials: C
authors.lastname: Lassek
authors.forename: Gabriele
authors.initials: G
authors.lastname: Klug
mesh_terms: D019843:Archaeal Proteins / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D019915:DNA Primase / Q000378:metabolism; D055354:Exosomes / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D011117:Polyribonucleotide Nucleotidyltransferase / Q000378:metabolism; D020365:RNA Helicases / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D019642:RNA, Archaeal / Q000378:metabolism*; D012329:RNA, Bacterial / Q000378:metabolism*; D012260:Ribonucleases / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D048229:Sulfolobus solfataricus / Q000235:genetics / Q000378:metabolism
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D008565:Membrane Proteins; D019642:RNA, Archaeal; D012329:RNA, Bacterial; D019915:DNA Primase; D011117:Polyribonucleotide Nucleotidyltransferase; D012260:Ribonucleases; D020365:RNA Helicases