title: Synthesis, antimicrobial and anticancer activity of new thiosemicarbazone derivatives.
abstract: Thiosemicarbazones of p-aminobenzoic acid (PABA) were synthesized and tested for their antimicrobial and anticancer activity. Hydroxamate derivatives 4a-4l were found to have better antimicrobial and anticancer activity than their acid counterpart. Compound 4d was found to have good antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Vibrio cholerae, and Bacillus subtilis with IC(50) value of about 1 µM. Compound 4f showed potent antifungal activity against Candida albicans (IC(50)  = 1.29 µM) and compound 4h showed potent anticancer activity (IC(50)  = 0.07 µM).
authors.affiliation: Medicinal Chemistry Research Division, Vaagdevi College of Pharmacy, Hanamkonda, Andhra Pradesh, India. youmasankar@rediffmail.com.
authors.forename: Umasankar
authors.initials: U
authors.lastname: Kulandaivelu
authors.forename: Valisakka Gari
authors.initials: VG
authors.lastname: Padmini
authors.forename: Kyatham
authors.initials: K
authors.lastname: Suneetha
authors.forename: Boyapati
authors.initials: B
authors.lastname: Shireesha
authors.forename: Jannu Vincent
authors.initials: JV
authors.lastname: Vidyasagar
authors.forename: Tadikonda Rama
authors.initials: TR
authors.lastname: Rao
authors.forename: Jayaveera
authors.initials: J
authors.lastname: K N
authors.forename: Arijit
authors.initials: A
authors.lastname: Basu
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Jayaprakash
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D019073:HT29 Cells; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D062366:para-Aminobenzoates
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D006877:Hydroxamic Acids; D013882:Thiosemicarbazones; D062366:para-Aminobenzoates; D000581:Amidohydrolases; C084507:peptide deformylase