title: Electroencephalographic characterization of seizure activity in the synapsin I/II double knockout mouse.
abstract: We present a detailed comparison of the behavioral and electrophysiological development of seizure activity in mice genetically depleted of synapsin I and synapsin II (SynDKO mice), based on combined video and surface EEG recordings. SynDKO mice develop handling-induced epileptic seizures at the age of 2months. The seizures show a very regular behavioral pattern, where activity is initially dominated by truncal muscle contractions followed by various myoclonic elements. Whereas seizure behavior goes through clearly defined transitions, cortical activity as reflected by EEG recordings shows a more gradual development with respect to the emergence of different EEG components and the frequency of these components. No EEG pattern was seen to define a particular seizure behavior. However, myoclonic activity was characterized by more regular patterns of combined sharp waves and spikes. Where countable, the number of myoclonic jerks was significantly correlated to the number of such EEG complexes. Furthermore, some EEG recordings revealed epileptic regular discharges without clear behavioral seizure correlates. Our findings suggest that seizure behavior in SynDKO mice is not solely determined by cortical activity but rather reflects interplay between cortical activity and activity in other brain regions.
authors.affiliation: Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, PO Box 1103 Blindern, N-0317 Oslo, Norway. lars.etholm@medisin.uio.no
authors.forename: Lars
authors.initials: L
authors.lastname: Etholm
authors.forename: Henrik
authors.initials: H
authors.lastname: Lindén
authors.forename: Torsten
authors.initials: T
authors.lastname: Eken
authors.forename: Paul
authors.initials: P
authors.lastname: Heggelund
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D012640:Seizures / Q000503:physiopathology*; D016704:Synapsins / Q000172:deficiency / Q000378:metabolism*
chemical_list: D016704:Synapsins