title: Neurogenesis in adult human brain after traumatic brain injury.
abstract: While much work has been conducted regarding the neurogenesis response to traumatic brain injury (TBI) in rodents, it remains largely unknown whether neurogenesis in adult human brain also responds to TBI in a similar manner. Here, we performed immunocytochemistry on 11 brain specimens from patients with traumatic brain injury, who underwent surgical intervention. We found that expression of neural stem/progenitor cell (NSC) protein markers, including DCX, TUC4, PSA-NCAM, SOX2 and NeuroD, was increased in the perilesional cortex of human brain after TBI compared to that of normal brain. Confocal images showed that these NSC proteins were expressed in one single cell. We also found that proliferative markers were expressed in NSC protein-positive cells after TBI, and the number of proliferative NSCs was significantly increased after TBI. Our data suggest that TBI may also induce neurogenesis in human brain.
authors.affiliation: 1 Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical College , Wenzhou, China .
authors.forename: WeiMing
authors.initials: W
authors.lastname: Zheng
authors.forename: Qichuan
authors.initials: Q
authors.lastname: ZhuGe
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
authors.forename: Gourong
authors.initials: G
authors.lastname: Chen
authors.forename: Bei
authors.initials: B
authors.lastname: Shao
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: XiaoOu
authors.initials: X
authors.lastname: Mao
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.forename: Kunlin
authors.initials: K
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*
chemical_list: D015415:Biomarkers