title: A case of well-tolerated and safe deferasirox administration during the first trimester of a spontaneous pregnancy in an advanced maternal age thalassemic patient.
abstract: In this report, we present a case of a spontaneous pregnancy in a 42-year-old thalassemic woman referred to our Microcythemic Unit while she was on deferasirox (DFX) therapy. The patient had been on treatment with DFX since March 2008 and in March 2009 realized that she was pregnant at 12 weeks of gestation. The conception was spontaneous and the baby was born at full term without complications or malformations.
authors.affiliation: Oncohematologic Department, Microcythemic Center 'A. Mastrobuoni', A. Cardarelli Hospital, Naples, Italy. pabloricchi@libero.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Ricchi
authors.forename: Silvia
authors.initials: S
authors.lastname: Costantini
authors.forename: Anna
authors.initials: A
authors.lastname: Spasiano
authors.forename: Tiziana
authors.initials: T
authors.lastname: Di Matola
authors.forename: Patrizia
authors.initials: P
authors.lastname: Cinque
authors.forename: Luciano
authors.initials: L
authors.lastname: Prossomariti
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001565:Benzoates / Q000008:administration & dosage / Q000627:therapeutic use*; D000077588:Deferasirox; D005260:Female; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008423:Maternal Age; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D017086:beta-Thalassemia / Q000188:drug therapy*
chemical_list: D001565:Benzoates; D007502:Iron Chelating Agents; D014230:Triazoles; D000077588:Deferasirox