title: [Roles of histamine in the pathogenesis of bronchial asthma and reevaluation of the clinical usefulness of antihistamines].
abstract: Histamine has been reported to play an important role in pathogenesis of bronchial asthma. However, H1-blockers are not recommended as the first drug for asthma therapy in the guidelines. Histamine may play various roles in allergic airway inflammation through the H1 receptor (H1R), H2R, and H4R in immune cells including T lymphocytes and dendritic cells. We therefore evaluated its role in allergic airway inflammation with the use of histamine-deficient mice. The results suggested that histamine plays a role in the prevention of goblet cell hyperplasia. Organic cation transporter-3 (OCT-3) is thought to be a transporter of histamine. Polymorphism of OCT-3 {R120R (T/C)} was associated with the severity of asthma. Recently, it has been proposed that both asthma and allergic rhinitis should be treated as a single airway disease. Comorbidity of asthma and allergic rhinitis is very high (70-80%) and they share similar allergic inflammation. H1-blockers are recommended as first-line drugs to treat allergic rhinitis in the guidelines. Therefore H1-blockers are strongly recommended for patients with both asthma and allergic rhinitis.
authors.affiliation: Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine. kyamauch@iwate-med.ac.jp
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Toshiki
authors.initials: T
authors.lastname: Shikanai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Masahito
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Maeyama
mesh_terms: D000818:Animals; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000209:etiology*; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D027701:Organic Cation Transport Proteins / Q000235:genetics; D011110:Polymorphism, Genetic; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy
chemical_list: D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D027701:Organic Cation Transport Proteins; D006632:Histamine