title: [Animal models for bone and joint disease. Low calcium diet-induced rat model of osteoporosis].
abstract: Amount of daily calcium (Ca) intake have direct impact on bone metabolism, because of an important mineral component of bone. Two months rearing with less than 0.3% Ca diet clarified effectiveness for a rat model of osteoporosis, resulted in a significant decrease in BMD and bone strength. Besides low Ca diet associated with ovariectomy also induced significant decrease in BMC and BMD in such a short-term. Otherwise precaution for assessment as to an experimental objective ought to be deliberated depend on which part of bone should be evaluated and how long rats should be reared.
authors.affiliation: University of Tsukuba,Graduate School of Comprehensive Human Sciences.
authors.forename: Naomi
authors.initials: N
authors.lastname: Omi
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ezawa
mesh_terms: D000818:Animals; D015519:Bone Density; D002118:Calcium / Q000172:deficiency*; D002136:Calcium, Dietary / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000209:etiology* / Q000378:metabolism; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002136:Calcium, Dietary; D002118:Calcium