title: Serum tartrate-resistant acid phosphatase isoform 5a (TRACP5a) as a potential risk marker in cardiovascular disease.
abstract: OBJECTIVE
  This study was undertaken to determine the association between serum tartrate-resistant acid phosphatase 5a (TRACP5a) and cardiovascular disease (CVD) risk.
  
  
  METHODS
  Four hundred patients were enrolled including, 291 asymptomatic subjects grouped by the number of traditional risk factors, 36 patients undergoing cardiac arteriography, 34 undergoing percutaneous cardiac intervention, and 39 with acute myocardial infarction. Serum was collected at baseline and, in arteriograpy and intervention groups, periodically for 1 week afterward. In addition to laboratory and clinical evaluation for risk assessment, serum TRACP5a, C-reactive protein (CRP) and interleukin-6 (IL-6) were determined.
  
  
  RESULTS
  All biomarkers rose with increasing CVD risk. Only serum TRACP5a, logCRP and cholesterol were elevated in symptomatic patients. Serum TRACP5a was higher in men and correlated with age, logCRP, logIL-6 and log-triglycerides, and in symptomatic patients, with the number of diseased coronary arteries. IL-6 and CRP showed acute phase responses, whereas TRACP5a did not change over 1 week after arteriography or intervention. After adjustment for all other variables and risk factors, TRACP5a and logCRP were the only biomarkers to associate with symptomatic disease. TRACP5a was more specific than CRP to predict myocardial infarction among all subjects.
  
  
  CONCLUSIONS
  Serum TRACP5a is a macrophage-derived inflammation marker associated with CVD risk, and with coronary vessel disease and its severity and may be a useful marker for screening and assessment of CVD risk.
authors.affiliation: Department of Veterans Affairs Medical Center, University of Louisville School of Medicine, Louisville, KY 40206, USA. anthony.Janckila@va.gov
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Janckila
authors.forename: Hseun-Fu
authors.initials: HF
authors.lastname: Lin
authors.forename: Yi-Ying
authors.initials: YY
authors.lastname: Wu
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Ku
authors.forename: Shih-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Wei-Shiang
authors.initials: WS
authors.lastname: Lin
authors.forename: Su-Huei
authors.initials: SH
authors.lastname: Lee
authors.forename: Lung T
authors.initials: LT
authors.lastname: Yam
authors.forename: Tsu-Yi
authors.initials: TY
authors.lastname: Chao
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000201:enzymology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology; D012307:Risk Factors; D000071681:Tartrate-Resistant Acid Phosphatase; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase