title: Pregnancy outcome in patients with fibromyalgia syndrome.
abstract: OBJECTIVE
  To investigate pregnancy outcome of patients with fibromyalgia syndrome (FMS).
  
  
  METHODS
  A retrospective cohort study comparing pregnancies of women with and without FMS was conducted. Multivariable logistic regression models was performed to control for confounders
  
  
  RESULTS
  Deliveries of 112 women with FMS were compared with a control group of 487 deliveries of women without FMS. Parturients with FMS had higher rates of intrauterine growth restriction (IUGR; 7.1% vs. 1.0%, p = 0.001), recurrent abortions (9.8% vs. 1.8%, p < 0.001), gestational diabetes mellitus (14.3% vs. 7%, p = 0.012), and polyhydramnios (12.5% vs. 1.6%, p < 0.001). These patients had lower rates of preterm deliveries (PTD; 6.3% vs. 16.7%, p = 0.018). No significant differences were noted between the groups regarding the rates of cesarean deliveries (CD) (15.2% vs. 21.2%, p = 0.149) and perinatal outcomes such as low Apgar scores (<7) at 1 and 5 min (4.5% vs. 6.7%, p = 0.292 and 1.2% vs. 0.6%, p = 0.372; respectively). Using two multiple logistic regression models, the positive association between FMS and IUGR (adjusted OR = 4.1, 95% CI 1.2-13.2; p = 0.02) and the negative association with PTD (OR = 0.3, 95% CI 0.2-0.6; p = 0.001) remained significant.
  
  
  CONCLUSIONS
  FMS is an independent risk factor for intrauterine growth restriction. Nevertheless, it is associated with lower rates of preterm deliveries.
authors.affiliation: Faculty of Health Sciences, Soroka University Medical Center, Be’er-Sheva, Israel.
authors.forename: Tammy
authors.initials: T
authors.lastname: Zioni
authors.forename: Dan
authors.initials: D
authors.lastname: Buskila
authors.forename: Barak
authors.initials: B
authors.lastname: Aricha-Tamir
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology; D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000453:epidemiology; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005356:Fibromyalgia; D006801:Humans; D016015:Logistic Models; D006831:Polyhydramnios / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors