title: Construction of spirolactones with concomitant formation of the fused quaternary centre--application to the synthesis of natural products.
abstract: Polycyclic structures fused at a central carbon are of great interest due to their appealing conformational features and their structural implications in biological systems. Although progress in the development of synthetic methodologies towards such structures has been impressive, the stereoselective construction of such quaternary stereocentres remains a significant challenge in the total synthesis of natural products. This review highlights the progress in the formation of 1-oxaspiro[4.n]alkan-2-ones (2≤n≤7) with concomitant formation of the quaternary spiro centre.
authors.affiliation: Aix-Marseille Université, Institut des Sciences Moléculaires de Marseille, iSm2-UMR CNRS 6263, Campus Saint Jérôme, Service 532, 13397, Marseille Cedex 20, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bartoli
authors.forename: Fabien
authors.initials: F
authors.lastname: Rodier
authors.forename: Laurent
authors.initials: L
authors.lastname: Commeiras
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Parrain
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Chouraqui
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013148:Spironolactone / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D013148:Spironolactone