title: Synthesis, characterization and biological evaluation of mononuclear Co(II), Ni(II), Cu(II) and Pd(II) complexes with new N2O2 Schiff base ligands.
abstract: New tetradentate N(2)O(2) donor Schiff bases and their mononuclear Co(II), Ni(II), Cu(II), and Pd(II) complexes were synthesized and characterized extensively by IR, (1)H-, (13)C-NMR, mass, ESR, conductivity measurements, elemental and thermal analysis. Specifically the magnetic and electronic spectral measurements demonstrate the octahedral structures of cobalt(II), nickel(II) complexes and square planar geometries of copper(II), palladium(II) complexes. All the ligands and complexes were screened for their in vitro antibacterial activity against two gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) and two gram-negative bacteria (Escherichia coli, Klebsiella pneumonia). In this study, Pd(II) complexes exhibited potent antibacterial activity against B. subtilis, S. aureus whereas other metal complexes also exerted good activity towards all tested strains even than standard drugs streptomycin and ampicillin.
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal, AP, India.
authors.forename: Geeta
authors.initials: G
authors.lastname: Budige
authors.forename: Muralidhar Reddy
authors.initials: MR
authors.lastname: Puchakayala
authors.forename: Shobha Rani
authors.initials: SR
authors.lastname: Kongara
authors.forename: Anren
authors.initials: A
authors.lastname: Hu
authors.forename: Ravinder
authors.initials: R
authors.lastname: Vadde
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008024:Ligands; D008826:Microbial Sensitivity Tests / Q000379:methods; D009532:Nickel / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry / Q000494:pharmacology; D010165:Palladium / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D008024:Ligands; D009589:Nitrogen Oxides; D012545:Schiff Bases; D003035:Cobalt; D010165:Palladium; D003300:Copper; D009532:Nickel