title: Association study of the GAB2 gene with the risk of Alzheimer disease in the chinese population.
abstract: OBJECTIVE
  To assess genetic variations of GAB2 as a risk factor for developing Alzheimer disease (AD).
  
  
  METHODS
  A case-control study (n=310; age>50 y) was conducted to determine the prevalence of 5 single nucleotide polymorphisms (SNPs) of GAB2 (rs2373115, rs1385600, rs4945261, rs7101429, and rs7115850) in patients with AD in Chinese population of mainland China, and was investigated whether these polymorphisms are risk factors for AD.
  
  
  RESULTS
  Our results supported a possible implication of 3 tested SNPs of GAB2 (rs4945261, rs7101429, and rs7115850) in AD in the ethnic Chinese Han, of which the maximal significance of association was at SNP rs7101429 C allele (P=4.0×10; odds ratio=2.0; 95% confidence interval, 1.4-2.8), and this observed association was not affected by APOEε4 genotype. In the haplotypes analysis, the minor alleles of the 3 tested SNPs were composed of a TCG haplotype, which had a significant difference in haplotype distribution between the 2 groups (P=3.4×10; odds ratio=8.32; 95% confidence interval, 4.57-15.14).
  
  
  CONCLUSIONS
  Our findings implicate an association between genetic variations of GAB2 and AD in Han Chinese, and the minor alleles of the 3 tested SNPs (rs4945261, rs7101429, and rs7115850) might increase the risk of AD.
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Pan
authors.forename: Pei-Jing
authors.initials: PJ
authors.lastname: Cui
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Ma
authors.forename: Ru-Jing
authors.initials: RJ
authors.lastname: Ren
authors.forename: Yu-Lei
authors.initials: YL
authors.lastname: Deng
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Tang
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C490895:GAB2 protein, human