title: Epidermolysis bullosa nevus-like lesions in a pediatric patient with pyoderma gangrenosum.
abstract: Epidermolysis bullosa-associated nevi are recently described dysplastic nevi found in patients with epidermolysis bullosa. These lesions display clinical features of unusual nevi suggestive of malignancy but thus far cases with malignant transformation have not been reported. We describe a case of epidermolysis bullosa-type nevi developing in a child with pyoderma gangrenosum. The nevi in our patient were found in areas previously affected by pyoderma gangrenosum and were clinically concerning for malignancy. However, they were only moderately atypical on light and confocal microscopy. This case demonstrates that pediatric patients with cutaneous inflammation, bullae formation, or both, are at risk for developing unusual nevi at previous sites of skin involvement. Considering the absence of malignant change in these nevi, we suggest that close observation can be employed in cases where this diagnosis can be confirmed both clinically and microscopically.
authors.affiliation: College of Medicine, University of Oklahoma, Oklahoma City, Oklahoma 73104, USA. todd-mollet@ouhsc.edu
authors.forename: Todd
authors.initials: T
authors.lastname: Mollet
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Henderson
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Groben
authors.forename: Craig N
authors.initials: CN
authors.lastname: Burkhart
authors.forename: Dean S
authors.initials: DS
authors.lastname: Morrell
mesh_terms: D002648:Child; D003879:Dermatologic Agents / Q000627:therapeutic use; D004416:Dysplastic Nevus Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004820:Epidermolysis Bullosa / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016559:Tacrolimus / Q000627:therapeutic use; D013625:Takayasu Arteritis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D011241:Prednisone; D016559:Tacrolimus