title: Discovered on gastrointestinal stromal tumor 1 (DOG1) is expressed in pancreatic centroacinar cells and in solid-pseudopapillary neoplasms--novel evidence for a histogenetic relationship.
abstract: Solid-pseudopapillary neoplasms of the pancreas are tumors of low malignant potential whose histogenesis has been discussed controversially. In the series of 15 solid-pseudopapillary neoplasms presented here, we demonstrate that discovered on gastrointestinal stromal tumor 1 is expressed significantly by these tumors (diffuse expression in 8 cases, focal expression in 4 cases, and scarce expression in 3 cases). Similar to the high expression of CD117, this finding parallels the immunohistochemical findings in gastrointestinal stromal tumors. Using double immunohistochemistry and immunofluorescence, we furthermore show that centroacinar cells express discovered on gastrointestinal stromal tumors 1. Thus, our findings suggest that, similarly to CD10 or vimentin, the expression of discovered on gastrointestinal stromal tumors 1 may serve as a novel marker for centroacinar cells and for solid-pseudopapillary neoplasms, which is suggestive of a centroacinar origin of these neoplasms.
authors.affiliation: Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany. frank.bergmann@med.uni-heidelberg.de
authors.forename: Frank
authors.initials: F
authors.lastname: Bergmann
authors.forename: Mindaugas
authors.initials: M
authors.lastname: Andrulis
authors.forename: Werner
authors.initials: W
authors.lastname: Hartwig
authors.forename: Roland
authors.initials: R
authors.lastname: Penzel
authors.forename: Matthias M
authors.initials: MM
authors.lastname: Gaida
authors.forename: Esther
authors.initials: E
authors.lastname: Herpel
authors.forename: Peter
authors.initials: P
authors.lastname: Schirmacher
authors.forename: Gunhild
authors.initials: G
authors.lastname: Mechtersheimer
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000075369:Anoctamin-1; D018118:Chloride Channels; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D046790:Pancreas, Exocrine / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: C476213:ANO1 protein, human; D000075369:Anoctamin-1; D018118:Chloride Channels; D008565:Membrane Proteins; D009363:Neoplasm Proteins