title: Cerebral infarction developing in a patient without cancer with a markedly elevated level of mucinous tumor marker.
abstract: Previous studies have shown the possible role of mucin in cerebral infarction associated with coagulation abnormalities in patients with cancer, particularly adenocarcinoma. We report a 42-year-old woman who developed motor aphasia and cerebral infarction in the left frontal lobe and right parietal lobe. A mucinous tumor marker, CA125 level, was markedly elevated at 1750 U/mL (normal, <36 U/mL), and the D-dimer level was 6.0 μg/mL (normal, <1 μg/mL). She had adenomyosis and no malignancy was revealed. The CA125 and the D-dimer levels became normal after treatment of adenomyosis. Our findings suggest for the first time that marked elevation of mucinous tumor marker level may cause cerebral infarction even in benign conditions.
authors.affiliation: Department of Neurology, Juntendo University Shizuoka Hospital, Shizuoka, Japan. kazuo-y@juntendo.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamashiro
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Furuya
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Noda
authors.forename: Takao
authors.initials: T
authors.lastname: Urabe
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Okuma
mesh_terms: D062788:Adenomyosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000328:Adult; D001039:Aphasia, Broca / Q000209:etiology; D018394:CA-125 Antigen / Q000097:blood*; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005625:Frontal Lobe / Q000098:blood supply*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010296:Parietal Lobe / Q000098:blood supply*; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D018394:CA-125 Antigen; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D