title: Disseminated fusariosis occurring in two patients despite posaconazole prophylaxis.
abstract: Posaconazole is widely used for prophylaxis against invasive fungal infections in patients undergoing myeloablative therapy. Disseminated fusariosis is a serious invasive mold infection in such patients. Preclinical and clinical studies indicate activity of posaconazole against Fusarium. We describe two cases of disseminated fusariosis that occurred despite posaconazole prophylaxis.
authors.affiliation: Section of Hematology/Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
authors.forename: Prithviraj
authors.initials: P
authors.lastname: Bose
authors.forename: Hiral D
authors.initials: HD
authors.lastname: Parekh
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Holter
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Greenfield
mesh_terms: D000328:Adult; D018890:Chemoprevention / Q000379:methods*; D005260:Female; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology* / Q000517:prevention & control; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D014230:Triazoles; C101425:posaconazole