title: Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.
abstract: A recent genome-wide association study (GWA) reported a significant association between single nucleotide polymorphisms (SNPs) at the PCDH11X gene and late-onset Alzheimer's disease (LOAD). Our research was designated to replicate this association, including non previously analyzed PCDH11X and PCDH11Y SNPs. We genotyped four PCDH11X and one PCDH11Y SNPs in a total of 420 LOAD patients and 350 healthy controls from Spain. Allele and genotype frequencies did not differ between patients and controls for the five SNPs, even after correcting by gender, age, and APOE-ε4 status. Our data were in agreement with recent reports that failed to confirm the association between PCDH11X polymorphisms and LOAD, and extended the lack of association to common PCDH11Y variants.
authors.affiliation: Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Miar
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Ana I
authors.initials: AI
authors.lastname: Corao
authors.forename: Belén
authors.initials: B
authors.lastname: Alonso
authors.forename: Marta
authors.initials: M
authors.lastname: Díaz
authors.forename: Manuel
authors.initials: M
authors.lastname: Menéndez
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.forename: Maite
authors.initials: M
authors.lastname: Calatayud
authors.forename: Germán
authors.initials: G
authors.lastname: Morís
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
mesh_terms: D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D015820:Cadherins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D000091363:Protocadherins
chemical_list: D001057:Apolipoproteins E; D015820:Cadherins; C404498:PCDH11X protein, human; C468654:PCDH11Y protein, human; D000091363:Protocadherins