title: Development of biocatalysts for production of commodity chemicals from lignocellulosic biomass.
abstract: Lignocellulosic biomass is recognized as potential sustainable source for production of power, biofuels and variety of commodity chemicals which would potentially add economic value to biomass. Recalcitrance nature of biomass is largely responsible for the high cost of its conversion. Therefore, it is necessary to introduce some cost effective pretreatment processes to make the biomass polysaccharides easily amenable to enzymatic attack to release mixed fermentable sugars. Advancement in systemic biology can provide new tools for the development of such biocatalysts for sustainable production of commodity chemicals from biomass. Integration of functional genomics and system biology approaches may generate efficient microbial systems with new metabolic routes for production of commodity chemicals. This paper provides an overview of the challenges that are faced by the processes converting lignocellulosic biomass to commodity chemicals. The critical factors involved in engineering new microbial biocatalysts are also discussed with more emphasis on commodity chemicals.
authors.affiliation: NCIM Resource Center, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Adsul
authors.forename: M S
authors.initials: MS
authors.lastname: Singhvi
authors.forename: S A
authors.initials: SA
authors.lastname: Gaikaiwari
authors.forename: D V
authors.initials: DV
authors.lastname: Gokhale
mesh_terms: D055162:Biocatalysis; D018533:Biomass; D001709:Biotechnology / Q000379:methods*; D008031:Lignin / Q000737:chemistry / Q000378:metabolism*; D009930:Organic Chemicals / Q000378:metabolism*
chemical_list: D009930:Organic Chemicals; C036909:lignocellulose; D008031:Lignin