title: Anti-inflammatory activity of the aqueous extract of ficus deltoidea.
abstract: Ficus deltoidea (Family Moraceae) leaves have been used traditionally by the Malays to treat ailments such as wounds, sores, and rheumatism. The aim of the present study was to determine the anti-inflammatory activity of the aqueous extract of F. deltoidea leaf (FDA) using acute and chronic inflammatory models. FDA, in the doses of 30, 100, and 300 mg/kg, was administered intraperitoneally in rats (n = 6) before the animals were subjected to the carrageenan-induced paw edema test, cotton pellet-induced granuloma test, and formalin test. The first two tests represent acute and chronic models of inflammation, respectively. The first and second phases of the formalin test represent neurogenic pain and inflammatory-mediated pain, respectively; thus, only the second phase was measured in the present study. Results showed that FDA exerted significant (p < .05) anti-inflammatory activity in all assays, with dose-response effects seen in the paw edema and formalin tests. In conclusion, the leaf of F. deltoidea possesses anti-inflammatory activity against acute and chronic inflammatory responses and against pain-associated inflammatory response. These findings justify the traditional uses of F. deltoidea leaves for treatment of inflammatory-mediated ailments.
authors.affiliation: Department of Biomedical Science, Universiti Putra Malaysia, Selangor, Malaysia. zaz@medic.upm.edu.my
authors.forename: Z A
authors.initials: ZA
authors.lastname: Zakaria
authors.forename: M K
authors.initials: MK
authors.lastname: Hussain
authors.forename: A S
authors.initials: AS
authors.lastname: Mohamad
authors.forename: F C
authors.initials: FC
authors.lastname: Abdullah
authors.forename: M R
authors.initials: MR
authors.lastname: Sulaiman
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D030681:Ficus / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014867:Water