title: Drug fever due to piperacillin/tazobactam loaded into bone cement.
abstract: Although drug fever may develop after administration of the drug by various routes, it has not been reported with antibiotic-loaded bone cement. Here, a case of drug fever induced by piperacillin/tazobactam loaded into bone cement is reported. A 72-yr-old woman presented with fever that developed two weeks after insertion of bone cement loaded with antibiotics including piperacillin/tazobactam into the knee joint for infectious arthritis. The fever was associated with a skin rash and blood eosinophilia. The work-up of the fever excluded several causes. Drug provocation test demonstrated that the piperacillin/tazobactam, which had been loaded in the bone cement, was the cause of the fever. The findings of this case suggest that drug fever can be induced by any drug placed and released continuously within the body. Therefore, the evaluation for possible drug fever should include all drugs the patient has been exposed to regardless of the route of administration.
authors.affiliation: Division of Allergy, Asthma and Clinical Immunology, Department of Internal Medicine, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hyun Bum
authors.initials: HB
authors.lastname: Park
authors.forename: Joon Seok
authors.initials: JS
authors.lastname: Choi
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Won Ju
authors.initials: WJ
authors.lastname: Kee
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Koh
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001168:Arthritis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D001843:Bone Cements / Q000009:adverse effects* / Q000737:chemistry*; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000009:adverse effects; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000009:adverse effects*; D000078142:Tazobactam
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D004791:Enzyme Inhibitors; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin