title: Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization.
abstract: In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid-liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50-250 μm. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration.
authors.affiliation: Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran. asefnejad_azadeh@yahoo.com
authors.forename: Azadeh
authors.initials: A
authors.lastname: Asefnejad
authors.forename: Aliasghar
authors.initials: A
authors.lastname: Behnamghader
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Khorasani
authors.forename: Babak
authors.initials: B
authors.lastname: Farsadzadeh
mesh_terms: D001842:Bone and Bones; D006882:Hydroxyapatites / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014867:Water; D014961:X-Ray Diffraction
chemical_list: D006882:Hydroxyapatites; D011140:Polyurethanes; D014867:Water; C028869:fluor-hydroxylapatite