title: Transcriptional and Posttranscriptional Programming by Long Noncoding RNAs.
abstract: Recently, several lines of evidence have suggested that noncoding RNAs, which include both small and long noncoding RNAs (ncRNAs), contribute to a significant portion of the transcriptome in eukaryotic organisms. However, the functional significance of this wide-spread occurrence of ncRNAs, and in particular, the long ncRNAs (lncRNAs), for organismal development and differentiation is unclear. The available evidence from a subset of lncRNAs suggests that certain lncRNAs, and/or the act of their transcription, are involved in important biological functions at the transcriptional and posttranscriptional level. This chapter discusses the epigenetic and nonepigenetic mechanisms by which lncRNAs and/or their transcription are involved in the programming of various biological functions in model systems, from yeast to mammals.
authors.affiliation: Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds Väg 20, 75185, Uppsala, Sweden.
authors.forename: Radha Raman
authors.initials: RR
authors.lastname: Pandey
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Kanduri
mesh_terms: D000818:Animals; D008322:Mammals; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D059467:Transcriptome
chemical_list: D062085:RNA, Long Noncoding; D022661:RNA, Untranslated