title: Epigenetic changes in individuals with arsenicosis.
abstract: Inorganic arsenic (iAs) is an environmental toxicant currently poisoning millions of people worldwide, and chronically exposed individuals are susceptible to arsenicosis or arsenic poisoning. Using a state-of-the-art technique to map the methylomes of our study subjects, we identified a large interactome of hypermethylated genes that are enriched for their involvement in arsenic-associated diseases, such as cancer, heart disease, and diabetes. Notably, we have uncovered an arsenic-induced tumor suppressorome, a complex of 17 tumor suppressors known to be silenced in human cancers. This finding represents a pivotal clue in unraveling a possible epigenetic mode of arsenic-induced disease.
authors.affiliation: Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, North Carolina 27599, United States.
authors.forename: Lisa
authors.initials: L
authors.lastname: Smeester
authors.forename: Julia E
authors.initials: JE
authors.lastname: Rager
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Bailey
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Guan
authors.forename: Nikia
authors.initials: N
authors.lastname: Smith
authors.forename: Gonzalo
authors.initials: G
authors.lastname: García-Vargas
authors.forename: Luz-Maria
authors.initials: LM
authors.lastname: Del Razo
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Drobná
authors.forename: Hemant
authors.initials: H
authors.lastname: Kelkar
authors.forename: Miroslav
authors.initials: M
authors.lastname: Stýblo
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Fry
mesh_terms: D001151:Arsenic / Q000633:toxicity*; D020261:Arsenic Poisoning / Q000235:genetics*; D018899:CpG Islands; D019175:DNA Methylation; D004781:Environmental Exposure / Q000009:adverse effects; D044127:Epigenesis, Genetic; D006801:Humans; D008800:Mexico; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply
chemical_list: D014874:Water Pollutants, Chemical; D001151:Arsenic