title: Chorioretinitis in a 7-year-old African girl, probably related to JSSc resolving to methotrexate therapy.
abstract: Juvenile systemic sclerosis (JSSc) is a rare but severe multi-system connective tissue disease of unknown etiology. It is one of the most difficult to treat rheumatic diseases in childhood and characterized by thickening and fibrosis of the skin and associated with fibrosis of internal organs. Eye involvement has rarely been reported. In a 7-year-old African girl, who presented with chorioretinitis and subsequently developed JSSc we discuss the possible association of chorioretinitis with JSSc and the putative implications of scleroderma vascular disease in the development of this complication and review the existing literature.
authors.affiliation: Rheumatologie und Immunologie, Klinik und Poliklinik für Kinder- und Jugendmedizin, Dresden, Germany. christian.hedrich@uniklinikumdresden.de
authors.forename: C M
authors.initials: CM
authors.lastname: Hedrich
authors.forename: A
authors.initials: A
authors.lastname: Leszczynska
authors.forename: J
authors.initials: J
authors.lastname: Hammermann
authors.forename: V
authors.initials: V
authors.lastname: Bau
authors.forename: M
authors.initials: M
authors.lastname: Gahr
mesh_terms: D002648:Child; D002825:Chorioretinitis / Q000175:diagnosis* / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005260:Female; D005858:Germany; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D019721:Ophthalmoscopes; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate