title: Hybrid bidentate phosphorus ligands in asymmetric catalysis: privileged ligand approach vs. combinatorial strategies.
abstract: In this perspective the development of chiral phosphorus ligands for asymmetric catalysis is discussed, with a special focus on hybrid bidentate phosphorus ligands, in particular phosphine-phosphoramidites. An attempt is made to compare privileged ligand and combinatorial approaches to ligand development--for which the class of phosphine-phosphoramidite ligands is well suited--highlighting differences, similarities and their complementary use.
authors.affiliation: Supramolecular & Homogeneous Catalysis Group, van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Wassenaar
authors.forename: Joost N H
authors.initials: JN
authors.lastname: Reek
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D010758:Phosphorus; D009584:Nitrogen