title: Dynamic contrast-enhanced ultrasonography (DCE-US) and anti-angiogenic treatments.
abstract: Dynamic contrast-enhanced ultrasonography (DCE-US) is a current functional imaging technique enabling a quantitative assessment of tumor perfusion using raw linear data. DCE-US allows calculating several parameters as slope of wash-in or area under the curve representing, respectively, blood flow or blood volume. Decrease of vascularization can easily be detected in responders after 1 or 2 weeks of anti-angiogenic treatment for gastrointestinal stromal tumors (GIST), renal cell carcinoma (RCC), and hepatocellular carcinoma (HCC) and is correlated with progression-free survival and overall survival in RCC or HCC. DCE-US is supported by the French National Cancer Institute (INCa), which is currently studying the technique in metastatic breast cancer, melanoma, colon cancer, gastrointestinal stromal tumors and renal cell carcinoma, as well as in primary hepatocellular carcinoma, to establish the optimal perfusion parameters and timing for quantitative anticancer efficacy assessments. Currently 479 patients are included in 19 centers and the preliminary results on 400 patients with 1096 DCE-US demonstrated that the area under the curve (AUC) quantified at 1 month could be a robust parameter to predict response at 6 months.
authors.affiliation: Imaging Department, Institut Gustave Roussy, Villejuif, France. Nathalie.Lassau@igr.fr
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lassau
authors.forename: Linda
authors.initials: L
authors.lastname: Chami
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chebil
authors.forename: Baya
authors.initials: B
authors.lastname: Benatsou
authors.forename: Sophie
authors.initials: S
authors.lastname: Bidault
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Girard
authors.forename: Ghassen
authors.initials: G
authors.lastname: Abboud
authors.forename: Alain
authors.initials: A
authors.lastname: Roche
mesh_terms: D002986:Clinical Trials as Topic; D003287:Contrast Media; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media