title: [Impaired fasting glucose and risk of diabetes mellitus at 10 years. Cohort study].
abstract: OBJECTIVE
  The aim of this study was to define the incidence of type 2 diabetes mellitus in patients with impaired fasting glucose and its association with risk factors.
  
  
  METHODS
  115 patients aged > 18 years old, randomly selected in a Healthcare Center, diagnosed of impaired fasting glucose with 1997 American Diabetes Association criteria, followed 10 years. Predictive factors for developing diabetes mellitus were: age, sex, smoking, hypertension, hypercholesterolemia, family history of type 2 diabetes mellitus, antecedent of diabetes in pregnancy, and obesity.
  
  
  RESULTS
  During the 10 years of follow-up, 33 patients developed type 2 diabetes mellitus (28.7%; 95% CI 20.4-37.0%), 57 patients progressed to normoglycaemia (49.6%; 95% CI 40.4-58.7%), and 25 patients remained with an impaired fasting glucose (21.7%; 95% CI 14.2-29.3%). Only obesity was associated with progression to type 2 diabetes mellitus (adjusted hazard ratio 2.01; 95% CI 1.00-4.03, p=0.050).
  
  
  CONCLUSIONS
  Half of the patients with impaired fasting glucose normalized their glycaemia, and 28.7% developed diabetes mellitus, especially patients with obesity. These results suggest a different natural history to respect glucose intolerance.
authors.affiliation: Centro de Salud La Marina, Barcelona, España. jbaenad@meditex.es
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Baena-Díez
authors.forename: Noemí
authors.initials: N
authors.lastname: Bermúdez-Chillida
authors.forename: Xavier
authors.initials: X
authors.lastname: Mundet
authors.forename: José Luis del
authors.initials: JL
authors.lastname: Val-García
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Muñoz
authors.forename: Helmut
authors.initials: H
authors.lastname: Schröder
mesh_terms: D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D018450:Disease Progression; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors