title: Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae.
abstract: The yeast Saccharomyces cerevisiae, with its full complement of organelles, synthesizes membrane phospholipids by pathways that are generally common to those found in higher eukaryotes. Phospholipid synthesis in yeast is regulated in response to a variety of growth conditions (e.g., inositol supplementation, zinc depletion, and growth stage) by a coordination of genetic (e.g., transcriptional activation and repression) and biochemical (e.g., activity modulation and localization) mechanisms. Phosphatidate (PA), whose cellular levels are controlled by the activities of key phospholipid synthesis enzymes, plays a central role in the transcriptional regulation of phospholipid synthesis genes. In addition to the regulation of gene expression, phosphorylation of key phospholipid synthesis catalytic and regulatory proteins controls the metabolism of phospholipid precursors and products.
authors.affiliation: Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA. carman@aesop.rutgers.edu
authors.forename: George M
authors.initials: GM
authors.lastname: Carman
authors.forename: Gil-Soo
authors.initials: GS
authors.lastname: Han
mesh_terms: D015966:Gene Expression Regulation, Fungal; D007294:Inositol / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D015394:Molecular Structure; D010743:Phospholipids / Q000096:biosynthesis* / Q000737:chemistry; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
chemical_list: D010743:Phospholipids; D029701:Saccharomyces cerevisiae Proteins; D007294:Inositol; D015032:Zinc