title: Atom probe tomography - a high throughput screening tool for atomic scale chemistry.
abstract: The objective of this paper is to examine the challenges and opportunities in high throughput screening of atomic scale chemistry via a technique known as atom probe tomography. While there are numerous methods that exist in the field of throughput screening, even at the nanoscale, most of the effort is on screening properties , rather than chemistry and/or structure. In this overview, we discuss the role atom probe tomography can have as a high throughput screening tool of atomic scale chemistry. Particular emphasis on the study of organic/ biological materials is given along with the needs and challenges to make atom probe tomography more widespread in the field of combinatorial chemistry.
authors.affiliation: Department of Materials Science & Engineering, Institute for Combinatorial Discovery, Iowa State University, Ames, 50011, USA. krajan@iastate.edu
authors.forename: Krishna
authors.initials: K
authors.lastname: Rajan
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry; D057166:High-Throughput Screening Assays / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods; D018625:Microscopy, Atomic Force / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D014054:Tomography / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D011506:Proteins; D004247:DNA