title: Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1.
abstract: Recognition of HIV-1 ssRNA by Toll-like receptor 7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here, we describe a novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-α (IFN-α), and the ability of plasmacytoid dendritic cells to produce IFN-α in response to HIV-1. IRF7 polymorphisms may, therefore, affect the ability of individuals to respond to HIV-1 and modulate HIV-1 disease progression.
authors.affiliation: Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
authors.forename: Judy
authors.initials: J
authors.lastname: Chang
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lindsay
authors.forename: Smita
authors.initials: S
authors.lastname: Kulkarni
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lifson
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
mesh_terms: D003713:Dendritic Cells / Q000378:metabolism*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D050839:Interferon Regulatory Factor-7 / Q000235:genetics*; D016898:Interferon-alpha / Q000096:biosynthesis*; D011110:Polymorphism, Genetic / Q000235:genetics*; D015398:Signal Transduction; D051217:Toll-Like Receptor 9 / Q000235:genetics*
chemical_list: D050839:Interferon Regulatory Factor-7; D016898:Interferon-alpha; D051217:Toll-Like Receptor 9