title: Three-month bilateral hopping intervention is ineffective in initiating bone biomarker response in healthy elderly men.
abstract: In animal studies, bone adaptation has been initiated successfully without the transient force spike associated with high impact exercises. Consequently, a 12-week bilateral hopping on the balls of the feet intervention was conducted. 25 elderly men (age 72(SD4) years, height 171(6) cm, weight 75(9) kg) were randomly assigned into exercise and control groups. Ten subjects in each group completed the study. Carboxyterminal propeptide of type I collagen (CICP), bone-specific alkaline phosphatase (bALP) and carboxyterminal telopeptide of type I collagen (CTx) were measured from venous blood samples at baseline, at 2 weeks and at the end of the intervention. Maximal ground reaction force (GRF), osteogenic index (OI) and jump height (JH) were determined from bilateral hopping test and balance was assessed with velocity of center of pressure (COP(velocity)) while standing on the preferred leg with eyes open. The intervention consisted of 5-7 sets of 10 s timed bilateral hopping exercise at 75-90% intensity three times/week. There was no significant group × time interaction for GRF, OI and JH (P = 0.065). GRF (11% change from baseline vs. 4%), OI (15 vs. 6%) and COP(velocity) (-10 vs. -1%) were not influenced by the intervention (P > 0.170), while the control group improved JH (P = 0.031) (2 vs. 18%). For the biomarkers, no effect was observed in MANOVA (P = 0.536) or in univariate analyses (P = 0.082 to P = 0.820) (CICP -2 vs. -3%, CTx 8 vs. -12%, bALP 0 vs. -3.7%). Allowing transient impact force spikes may be necessary to initiate a bone response in elderly men as the intervention was ineffective.
authors.affiliation: Neuromuscular Research Center, Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland. timo.j.rantalainen@jyu.fi
authors.forename: Timo
authors.initials: T
authors.lastname: Rantalainen
authors.forename: M
authors.initials: M
authors.lastname: Hoffrén
authors.forename: V
authors.initials: V
authors.lastname: Linnamo
authors.forename: A
authors.initials: A
authors.lastname: Heinonen
authors.forename: P V
authors.initials: PV
authors.lastname: Komi
authors.forename: J
authors.initials: J
authors.lastname: Avela
authors.forename: B C
authors.initials: BC
authors.lastname: Nindl
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism / Q000502:physiology; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood / Q000378:metabolism; D005081:Exercise Therapy / Q000379:methods*; D006262:Health; D006801:Humans; D008297:Male; D009068:Movement / Q000502:physiology; D010455:Peptides / Q000097:blood / Q000378:metabolism; D004856:Postural Balance / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase