title: Transannular dipolar cycloaddition as an approach towards the synthesis of the core ring system of the sarain alkaloids.
abstract: Intramolecular transannular dipolar cycloaddition was investigated as a key step in a synthetic approach to the core of the sarain alkaloids; although the use of an azomethine ylide was unsuccessful with the chosen aldehyde substrate, cycloaddition with a nitrone did give the alternative regioisomeric bridged cycloadduct.
authors.affiliation: Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UK S3 7HF.
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Franklin
authors.forename: David
authors.initials: D
authors.lastname: Bensa
authors.forename: Harry
authors.initials: H
authors.lastname: Adams
authors.forename: Iain
authors.initials: I
authors.lastname: Coldham
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D001952:Bridged-Ring Compounds