title: Migraine in patients with eating disorders: a study using a sister-pair comparison design.
abstract: OBJECTIVE
  To evaluate the relationship between migraine and eating disorders by applying a special study design.
  
  
  BACKGROUND
  To date, only a few studies have assessed eating disorders and eating behavior in patients with migraine.
  
  
  METHODS
  The distinctive feature of this design is the comparison of sister pairs with one sister suffering from an eating disorder according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition and the other being free of such disease.
  
  
  RESULTS
  We investigated 120 female patients with a median age of 24 years (interquartile range 20-31) as well as their non-eating-disordered sisters with a median age of 24 (20-31) years. Headache was diagnosed according to the International Classification of Headache Disorders, Second Edition. Thirteen sister pairs were concordant for the presence of migraine, 67 were concordant for the absence of migraine and 40 were discordant. Among the latter, 21 patients and 19 controls had migraine. The prevalence of migraine was virtually identical in patients (28%) and controls (27%).
  
  
  CONCLUSIONS
  This clinic-based controlled study using a sister-pair comparison design showed no evidence of an increased prevalence of migraine among patients with eating disorder.
authors.affiliation: Headache Unit at the Department of Neurology, Medical University of Vienna, Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Seidel
authors.forename: Andreas
authors.initials: A
authors.lastname: Karwautz
authors.forename: Gudrun
authors.initials: G
authors.lastname: Wagner
authors.forename: Arno
authors.initials: A
authors.lastname: Zormann
authors.forename: Harald
authors.initials: H
authors.lastname: Eder
authors.forename: Julia
authors.initials: J
authors.lastname: Huemer
authors.forename: Sofia
authors.initials: S
authors.lastname: Nattiashvili
authors.forename: Chistian
authors.initials: C
authors.lastname: Wöber
authors.forename: Çiçek
authors.initials: Ç
authors.lastname: Wöber-Bingöl
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000453:epidemiology; D015992:Body Mass Index; D001068:Feeding and Eating Disorders / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D035781:Siblings