title: Novel treatment of atypical human papillomavirus-associated epithelial hyperplasia with cidofovir.
abstract: OBJECTIVE
  We report a severe case of human papillomavirus-associated epithelial hyperplasia in a man infected with human immunodeficiency virus. These lesions were recalcitrant to treatment with surgical modalities and were eventually controlled with the daily application of a topical cidofovir gel.
  
  
  METHODS
  A single case is presented, along with a relevant review of the published data.
  
  
  RESULTS
  Before the initiation of cidofovir treatment, the patient had approximately 80% of his gingiva and buccal mucosa engrossed by confluent papillomatous lesions. At 2 weeks after cidofovir treatment, the lesions had markedly regressed, and by 4 weeks, they were almost fully resolved. No untoward adverse reactions occurred.
  
  
  CONCLUSIONS
  Cidofovir formulated as a gel can be safe and effective for the treatment of epithelial hyperplasia in those with human immunodeficiency virus infection.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Case School of Dental Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Collette
authors.forename: Marc A
authors.initials: MA
authors.lastname: Zechel
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000188:drug therapy*; D000998:Antiviral Agents / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000150:complications; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D004848:Epithelium / Q000473:pathology; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015394:Molecular Structure; D009059:Mouth Diseases / Q000188:drug therapy* / Q000821:virology*; D009061:Mouth Mucosa / Q000473:pathology; D063065:Organophosphonates / Q000737:chemistry / Q000627:therapeutic use*; D030361:Papillomavirus Infections / Q000150:complications / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir