title: Predictors of outcome in term infants with neonatal seizures subsequent to intrapartum asphyxia.
abstract: The objective of this study was to define potential clinical prognostic factors for term infants with neonatal seizures subsequent to intrapartum asphyxia. The authors completed a retrospective analysis of 62 term infants with clinical neonatal seizures subsequent to intrapartum asphyxia. Logistic regression analysis was applied to determine the independent prognostic indicators of an adverse outcome. A total of 23 (37%) infants had a normal outcome, 34 (55%) survived with 1 or more neurodevelopmental impairments (23 cerebral palsy, 28 global developmental delay, 15 epilepsy, with 18 combination of two, and 9 all three), and 5 (8%) died. Six variables were associated with an adverse outcome, but only the presence of meconium aspiration, a low (≤ 3) 1-minute Apgar score, seizure type other than focal clonic, and moderately severely abnormal electroencephalography (EEG) background findings were independently associated with an adverse outcome. Signs of acute distress are predictors of adverse outcome, alongside seizure semiology and moderate to severe EEG background abnormalities.
authors.affiliation: Departments of Neurology/Neurosurgery & Pediatrics, McGill University, and Division of Pediatric Neurology, Montreal Children's Hospital-McGill University Health Center, Montreal, Quebec Canada.
authors.forename: Jarred
authors.initials: J
authors.lastname: Garfinkle
authors.forename: Michael I
authors.initials: MI
authors.lastname: Shevell
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications* / Q000175:diagnosis*; D002675:Child, Preschool; D018450:Disease Progression; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000150:complications* / Q000628:therapy; D012720:Severity of Illness Index