title: Prenatal findings in congenital leukemia: a case report.
abstract: We here describe a case of congenital leukemia that ended in intrauterine fetal demise at 30 weeks of gestation. Acute enlargement of the fetal trunk, elevated pulsatility index of the umbilical artery with concomitant decline of pulsatility index of the middle cerebral artery, pleural effusion, and polyhydramnios preceded the fetal death. Diagnosis of congenital myeloid leukemia was suggested by microscopic examination of the placental tissue, revealing immature myeloid precursors filling the lumina of fetal vessels in the umbilical cord and chorionic villi. Extensive vascular involvement of the placenta by leukemic cells was considered to be a primary cause of the fetal death.
authors.affiliation: Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan. yukiyasu @ kuhp.kyoto-u.ac.jp
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Sato
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Izumi
authors.forename: Katsura
authors.initials: K
authors.lastname: Minegishi
authors.forename: Munekazu
authors.initials: M
authors.lastname: Komada
authors.forename: Shigehito
authors.initials: S
authors.lastname: Yamada
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Kakui
authors.forename: Keiji
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Mikami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Ikuo
authors.initials: I
authors.lastname: Konishi
mesh_terms: D002585:Cesarean Section; D002824:Chorionic Villi / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005315:Fetal Diseases / Q000473:pathology* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007951:Leukemia, Myeloid / Q000151:congenital* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D010996:Pleural Effusion; D011247:Pregnancy; D011673:Pulsatile Flow; D050497:Stillbirth; D014469:Umbilical Arteries / Q000503:physiopathology; D014470:Umbilical Cord / Q000473:pathology