title: First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines via a catalyst-free three-component reaction.
abstract: cis-2,3-Dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines were stereoselectively synthesized using a one-pot, catalyst-free, three-component reaction. This novel, efficient and convenient approach was used to synthesize 22 related products in moderate to excellent yields, demonstrating the scope and potential economic impact of the reaction.
authors.affiliation: Department of Chemistry, Shanghai University, 99 Shangda Rd, Shanghai 200444, People's Republic of China.
authors.forename: Jiechao
authors.initials: J
authors.lastname: Xu
authors.forename: Jiamei
authors.initials: J
authors.lastname: Wei
authors.forename: Linglin
authors.initials: L
authors.lastname: Bian
authors.forename: Jiaping
authors.initials: J
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Hongmei
authors.initials: H
authors.lastname: Deng
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Cao
mesh_terms: D000478:Alkylation; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D054879:Halogenation; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D001569:Benzodiazepines