title: Stereotactic radiotherapy for adrenal gland metastases: university of Florence experience.
abstract: OBJECTIVE
  To evaluate a retrospective single-institution outcome after hypofractionated stereotactic body radiotherapy (SBRT) for adrenal metastases.
  
  
  METHODS
  Between February 2002 and December 2009, we treated 48 patients with SBRT for adrenal metastases. The median age of the patient population was 62.7 years (range, 43-77 years). In the majority of patients, the prescription dose was 36 Gy in 3 fractions (70% isodose, 17.14 Gy per fraction at the isocenter). Eight patients were treated with single-fraction stereotactic radiosurgery and forty patients with multi-fraction stereotactic radiotherapy.
  
  
  RESULTS
  Overall, the series of patients was followed up for a median of 16.2 months (range, 3-63 months). At the time of analysis, 20 patients were alive and 28 patients were dead. The 1- and 2-year actuarial overall survival rates were 39.7% and 14.5%, respectively. We recorded 48 distant failures and 2 local failures, with a median interval to local failure of 4.9 months. The actuarial 1-year disease control rate was 9%; the actuarial 1- and 2-year local control rate was 90%.
  
  
  CONCLUSIONS
  Our retrospective study indicated that SBRT for the treatment of adrenal metastases represents a safe and effective option with a control rate of 90% at 2 years.
authors.affiliation: Clinical Radiobiological Institute, University of Florence, Florence, Italy. f.casamassima@dfc.unifi.it
authors.forename: Franco
authors.initials: F
authors.lastname: Casamassima
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Livi
authors.forename: Stefano
authors.initials: S
authors.lastname: Masciullo
authors.forename: Claudia
authors.initials: C
authors.lastname: Menichelli
authors.forename: Laura
authors.initials: L
authors.lastname: Masi
authors.forename: Icro
authors.initials: I
authors.lastname: Meattini
authors.forename: Ivano
authors.initials: I
authors.lastname: Bonucci
authors.forename: Benedetta
authors.initials: B
authors.lastname: Agresti
authors.forename: Gabriele
authors.initials: G
authors.lastname: Simontacchi
authors.forename: Raffaela
authors.initials: R
authors.lastname: Doro
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D000328:Adult; D000368:Aged; D000465:Algorithms; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods; D012119:Respiration; D012189:Retrospective Studies; D015996:Survival Rate; D047368:Tumor Burden