title: Breast cancer risk after radiation treatment at infancy: potential consequences of radiation-induced genomic instability.
abstract: Swedish hemangioma patients were treated in infancy mainly by external application of radium-226 starting from 1920. This work analysed the radiation risk among 17,158 women with a total of 678 breast cancer incidence cases with models of carcinogenesis and empirical excess relative risk models. Models incorporating effects of genomic instability were developed and applied to the hemangioma cohort. The description of the radiation risk was significantly improved with a model of genomic instability at an early stage of carcinogenesis.
authors.affiliation: Helmholtz Zentrum München, Institute of Radiation Protection, 85764 Neuherberg, Germany. markus.eidemueller@helmholtz-muenchen.de
authors.forename: Markus
authors.initials: M
authors.lastname: Eidemüller
authors.forename: Erik
authors.initials: E
authors.lastname: Holmberg
authors.forename: Peter
authors.initials: P
authors.lastname: Jacob
authors.forename: Marie
authors.initials: M
authors.lastname: Lundell
authors.forename: Per
authors.initials: P
authors.lastname: Karlsson
mesh_terms: D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D005260:Female; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007223:Infant; D008875:Middle Aged; D008957:Models, Genetic; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000235:genetics*; D020266:Radiotherapy, Conformal / Q000706:statistics & numerical data*; D018570:Risk Assessment; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult