title: Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia.
abstract: We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located within a class 1 integron carried on a large plasmid. Further studies are needed to clarify its epidemiological and clinical impact.
authors.affiliation: International Center for Medical Research and Training (CIDEIM), Carrera 125 # 19-225, Cali, Colombia.
authors.forename: Maria Camila
authors.initials: MC
authors.lastname: Montealegre
authors.forename: Adriana
authors.initials: A
authors.lastname: Correa
authors.forename: David F
authors.initials: DF
authors.lastname: Briceño
authors.forename: Natalia C
authors.initials: NC
authors.lastname: Rosas
authors.forename: Elsa
authors.initials: E
authors.lastname: De La Cadena
authors.forename: Sory J
authors.initials: SJ
authors.lastname: Ruiz
authors.forename: Maria F
authors.initials: MF
authors.lastname: Mojica
authors.forename: Ruben Dario
authors.initials: RD
authors.lastname: Camargo
authors.forename: Ivan
authors.initials: I
authors.lastname: Zuluaga
authors.forename: Adriana
authors.initials: A
authors.lastname: Marin
authors.forename: John P
authors.initials: JP
authors.lastname: Quinn
authors.forename: Maria Virginia
authors.initials: MV
authors.lastname: Villegas
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003105:Colombia; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D032023:Integrons / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000737:chemistry; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases