title: Equipoise and the dilemma of randomized clinical trials.
authors.affiliation: Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Franklin G
authors.initials: FG
authors.lastname: Miller
authors.forename: Steven
authors.initials: S
authors.lastname: Joffe
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003606:Dacarbazine / Q000627:therapeutic use; D032984:Ethics, Research; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D008545:Melanoma / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic / Q000941:ethics*; D013449:Sulfonamides / Q000627:therapeutic use; D057212:Therapeutic Equipoise; D016896:Treatment Outcome; D035501:Uncertainty; D000077484:Vemurafenib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D013449:Sulfonamides; D000077484:Vemurafenib; D003606:Dacarbazine