title: Superpulsed laser therapy on healing process after tooth extraction in patients waiting for liver transplantation.
abstract: Alveolar healing following tooth extraction is a complex repair process involving different tissues, including epithelium and bone. This research aimed to study the effect of laser therapy on alveolar healing process in patients waiting for liver transplantation, evaluating some inflammation, osteogenesis, and clinical parameters. Twelve patients with hepatic failure waiting for liver transplantation, with indications to bilateral extraction, entered the split-mouth study. One post-extractive defect was treated with laser while the other was left without treatment. Specimens of soft tissues were removed from around the tooth before extraction and after 7 days. Superpulsed laser irradiation prevented IL-1β increase and induced IL-6, IL-10, and collagen III increase at 7 days in comparison to their level before extraction, whereas the other parameters were unmodified. Moreover, the epithelial regeneration evidenced a positive result of laser therapy, and the patients reported less pain in the site treated with laser. In conclusion, laser therapy appears to be the treatment of choice for patients due to its clinical efficacy, safety, good tolerance, and its ability to prevent inflammation.
authors.affiliation: Oral Surgery Unit, Dentistry Section, Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Mozzati
authors.forename: Germana
authors.initials: G
authors.lastname: Martinasso
authors.forename: Nadia
authors.initials: N
authors.lastname: Cocero
authors.forename: Renato
authors.initials: R
authors.lastname: Pol
authors.forename: Marina
authors.initials: M
authors.lastname: Maggiora
authors.forename: Giuliana
authors.initials: G
authors.lastname: Muzio
authors.forename: Rosa Angela
authors.initials: RA
authors.lastname: Canuto
mesh_terms: D000539:Alveolar Process / Q000528:radiation effects*; D016207:Cytokines / Q000378:metabolism; D024022:Fibrillar Collagens / Q000378:metabolism; D006801:Humans; D053685:Laser Therapy; D017093:Liver Failure / Q000150:complications* / Q000503:physiopathology; D016031:Liver Transplantation; D010012:Osteogenesis / Q000528:radiation effects*; D060888:Real-Time Polymerase Chain Reaction; D014081:Tooth Extraction; D014945:Wound Healing / Q000502:physiology / Q000528:radiation effects*
chemical_list: D016207:Cytokines; D024022:Fibrillar Collagens