title: Coding region: the neglected post-transcriptional code.
abstract: The control of mammalian mRNA turnover and translation has been linked almost exclusively to specific cis-elements within the 5'- and 3'-untranslated regions (UTRs) of the mature mRNA. However, instances of regulated turnover and translation via cis-elements within the coding region (CR) of mRNAs are accumulating. Here, we describe the regulation of post-transcriptional fate through trans-binding factors (RNA-binding proteins and microRNAs) that function via CR sequences. We discuss how the CR enriches the post-transcriptional control of gene expression, and predict that new high-throughput technologies will enable a more mainstream study of CR-governed gene regulation.
authors.affiliation: Laboratory of Cellular and Molecular Biology, NIA-IRP, NIH, Baltimore, MD, USA.
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Lee
authors.forename: Myriam
authors.initials: M
authors.lastname: Gorospe
mesh_terms: D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000378:metabolism; D005786:Gene Expression Regulation; D035683:MicroRNAs / Q000378:metabolism*; D016366:Open Reading Frames; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D016601:RNA-Binding Proteins / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D020506:Untranslated Regions
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D035683:MicroRNAs; D016601:RNA-Binding Proteins; D034743:RNA-Induced Silencing Complex; D020506:Untranslated Regions; C497683:FMR1 protein, human