title: Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3.
abstract: A panel of members of the 2009 International Myeloma Workshop developed guidelines for standard investigative workup of patients with suspected multiple myeloma. Both serum and urine should be assessed for monoclonal protein. Measurement of monoclonal protein both by densitometer tracing and/by nephelometric quantitation is recommended, and immunofixation is required for confirmation. The serum-free light chain assay is recommended in all newly diagnosed patients with plasma cell dyscrasias. Bone marrow aspiration and/or biopsy along with demonstration of clonality of plasma cells are necessary. Serum β(2)-microglobulin, albumin, and lactate dehydrogenase are necessary for prognostic purposes. Standard metaphase cytogenetics and fluorescent in situ hybridization for 17p, t(4;14), and t(14;16) are recommended. The skeletal survey remains the standard method for imaging screening, but magnetic resonance imaging frequently provides valuable diagnostic and prognostic information. Most of these tests are repeated during follow-up or at relapse.
authors.affiliation: University of Athens, Athens, Greece. mdimop@med.uoa.gr
authors.forename: Meletios
authors.initials: M
authors.lastname: Dimopoulos
authors.forename: Robert
authors.initials: R
authors.lastname: Kyle
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Fermand
authors.forename: S Vincent
authors.initials: SV
authors.lastname: Rajkumar
authors.forename: Jesus
authors.initials: J
authors.lastname: San Miguel
authors.forename: Asher
authors.initials: A
authors.lastname: Chanan-Khan
authors.forename: Heinz
authors.initials: H
authors.lastname: Ludwig
authors.forename: Douglas
authors.initials: D
authors.lastname: Joshua
authors.forename: Jayesh
authors.initials: J
authors.lastname: Mehta
authors.forename: Morie
authors.initials: M
authors.lastname: Gertz
authors.forename: Hervé
authors.initials: H
authors.lastname: Avet-Loiseau
authors.forename: Meral
authors.initials: M
authors.lastname: Beksaç
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Anderson
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.forename: Seema
authors.initials: S
authors.lastname: Singhal
authors.forename: Hartmut
authors.initials: H
authors.lastname: Goldschmidt
authors.forename: Mario
authors.initials: M
authors.lastname: Boccadoro
authors.forename: Shaji
authors.initials: S
authors.lastname: Kumar
authors.forename: Sergio
authors.initials: S
authors.lastname: Giralt
authors.forename: Nikhil C
authors.initials: NC
authors.lastname: Munshi
authors.forename: Sundar
authors.initials: S
authors.lastname: Jagannath
mesh_terms: D002869:Chromosome Aberrations; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000628:therapy; D009194:Myeloma Proteins / Q000032:analysis; D010265:Paraproteinemias / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000628:therapy; D011379:Prognosis; D012008:Recurrence
chemical_list: D007147:Immunoglobulin Light Chains; D009194:Myeloma Proteins