title: Interleukin-1 (IL-1) in stress-induced activation of limbic-hypothalamic-pituitary adrenal axis.
abstract: Proinflammatory cytokine interleukin-1 (IL-1) produced during psychological and immunological stress, plays a significant role in the neuroendocrine and stress responses. Brain IL-1 is an important mediator in stress-induced stimulation of the limbic-hypothalamic-pituitary-adrenal axis and secretion of ACTH and corticosterone. This review aims to describe some signaling pathways between the limbic-hypothalamic-pituitary structures during prolonged stress responses including their sensitization and adaptation. Interleukin-1 represents an important central component operating in neurochemical and immune network for efficient coping in preventing stress-associated psycho- and neuropathology.
authors.affiliation: Department of Physiology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland. gadek@if-pan.krakow.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Gądek-Michalska
authors.forename: Jan
authors.initials: J
authors.lastname: Bugajski
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D007375:Interleukin-1 / Q000494:pharmacology* / Q000502:physiology*; D053583:Interleukin-1beta / Q000494:pharmacology / Q000502:physiology; D051379:Mice; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013312:Stress, Physiological; D013315:Stress, Psychological
chemical_list: D007375:Interleukin-1; D053583:Interleukin-1beta; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone