title: Preparation and characterization of carnauba wax nanostructured lipid carriers containing benzophenone-3.
abstract: Nanostructured lipid carriers (NLCs) are potential active delivery systems based on mixtures of solid lipids and liquid oil. In this paper, aqueous dispersions of NLCs were prepared by a hot high-pressure homogenization technique using carnauba wax as the solid lipid and isodecyl oleate as the liquid oil. The preparation and stability parameters of benzophenone-3-loaded NLCs have been investigated concerning particle size, zeta potential and loading capacity to encapsulate benzophenone-3, a molecular sunscreen. The current investigation illustrates the effect of the composition of the lipid mixture on the entrapment efficiency, in vitro release and stability of benzophenone-3-loaded in these NLCs. A loading capacity of approximately 5% of benzophenone-3 (m(BZ-3) /m(lipids) ) was characteristic of these systems.
authors.affiliation: Post-Graduate program in Pharmacy, Federal University of Pernambuco, Recife-PE, Brazil.
authors.forename: S P
authors.initials: SP
authors.lastname: Lacerda
authors.forename: N N P
authors.initials: NN
authors.lastname: Cerize
authors.forename: M I
authors.initials: MI
authors.lastname: Ré
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000032:analysis*; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D008055:Lipids / Q000008:administration & dosage*; D049329:Nanostructures; D013552:Swine; D014885:Waxes / Q000737:chemistry*
chemical_list: D001577:Benzophenones; D004337:Drug Carriers; D008055:Lipids; D014885:Waxes; C005290:oxybenzone; C026344:carnauba wax