title: Cross state-dependency of learning between WIN55, 212-2 and scopolamine in rat dorsal hippocampus.
abstract: In the current study, cross state-dependent learning between the cannabinoid CB1/CB2 receptor agonist WIN55, 212-2 (WIN) and muscarinic receptor antagonist scopolamine (SCO) in a step-through inhibitory avoidance task was investigated. All drugs were injected bilaterally into the dorsal hippocampus (intra-CA1) of rats. Data indicated that the immediate post-training administration of WIN (0.25 and 0.5μg/rat) and SCO (2 and 4μg/rat) decreased memory consolidation and induced amnesia. Moreover, the amnesia induced by the post-training injections of WIN (0.5μg/rat) or SCO (2μg/rat) was restored by either pre-test injections of WIN (0.25 and 0.5μg/rat) or SCO (2 and 4μg/rat). Furthermore, pre-test co-administration of ineffective doses of WIN (0.1μg/rat) with SCO (1μg/rat) restored amnesia induced by the post-training injections of WIN (0.5μg/rat) or SCO (2μg/rat). In conclusion, the data strongly revealed a cross state-dependent learning between WIN and SCO in the rat dorsal hippocampus.
authors.affiliation: Institute for Cognitive Science Studies (ICSS), Tehran, Iran.
authors.forename: Nida
authors.initials: N
authors.lastname: Jamali-Raeufy
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nasehi
authors.forename: Mohaddeseh
authors.initials: M
authors.lastname: Ebrahimi-Ghiri
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Zarrindast
mesh_terms: D000818:Animals; D048588:Benzoxazines / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D009025:Morpholines / Q000494:pharmacology*; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology*
chemical_list: D048588:Benzoxazines; D002121:Calcium Channel Blockers; D009025:Morpholines; D018727:Muscarinic Antagonists; D009281:Naphthalenes; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone; D012601:Scopolamine