title: Quantitative correlation between production rate of melanoma inhibitory activity and aggrecan gene expression level during differentiation from mesenchymal stem cells to chondrocytes and redifferentiation of chondrocytes.
abstract: The cell-specific production rate of melanoma inhibitory activity was quantitatively proportional to the aggrecan gene expression level in the early and middle phase during not only the redifferentiation culture of human cartilage chondrocytes but also the differentiation culture of human bone marrow mesenchymal stem cells to chondrocytes.
authors.affiliation: Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Kita-ku, Sapporo, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Onoue
authors.forename: Hideki
authors.initials: H
authors.lastname: Kusubashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sato
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Wakitani
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Takagi
mesh_terms: D000368:Aged; D053674:Aggrecans / Q000235:genetics / Q000378:metabolism*; D002356:Cartilage / Q000166:cytology; D002454:Cell Differentiation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology* / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism
chemical_list: D053674:Aggrecans; D016326:Extracellular Matrix Proteins; C090059:MIA protein, human; D009363:Neoplasm Proteins