title: Endothelium-derived hyperpolarizing factor and diabetes.
abstract: In addition to its role as a barrier between blood and tissues, the vascular endothelium is responsible for the synthesis and released of a number of vasodilators including prostaglandins, nitric oxide and endothelium-derived hyperpolarizing factor (EDHF). As one of these vasodilators, the specific nature of EDHF has not been fully elucidated, although a number of roles have been proposed. Importantly, many conditions, such as hypertension, hyperlipidemia, heart failure, ischemia-reperfusion and diabetes mellitus comprise vascular endothelial dysfunction with EDHF dysregulation. This article reviews reports on the role of EDHF in diabetes-related endothelial dysfunction.
authors.affiliation: Xue Gao, Department of Physiology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100005, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Gao
authors.forename: Luis A
authors.initials: LA
authors.lastname: Martinez-Lemus
authors.forename: Cuihua
authors.initials: C
authors.lastname: Zhang