title: Pharmacotherapy for obese adolescents.
abstract: The pharmaceutical search to induce weight loss was precipitated by the United States Food and Drug Administration's (FDA) 1959 formal approval of phentermine for short-term weight loss despite limited research supporting its assertions of weight loss. In addition to sympathomimetic amine products like phentermine, other medications considered in this article include herbal products, sibutramine, orlistat, metformin, and rimonabant. The use of pharmacotherapy for morbidly obese adolescents should be part of a comprehensive weight-loss program that recommends diet, exercise, and behavioral modification. Side effects and the possibility of major adverse effects should be remembered when considering use of these products.
authors.affiliation: Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, Kalamazoo, MI 49009-1284, USA. greydanus@kcms.msu.edu
authors.forename: Donald E
authors.initials: DE
authors.lastname: Greydanus
authors.forename: Lee A
authors.initials: LA
authors.lastname: Bricker
authors.forename: Cynthia
authors.initials: C
authors.lastname: Feucht
mesh_terms: D000293:Adolescent; D000662:Amphetamines / Q000627:therapeutic use; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D020934:Ciliary Neurotrophic Factor / Q000627:therapeutic use*; D029001:Herbal Medicine; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy*; D010880:Piperidines / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use; D000077285:Rimonabant
chemical_list: D000662:Amphetamines; D019440:Anti-Obesity Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D000697:Central Nervous System Stimulants; D020934:Ciliary Neurotrophic Factor; D007004:Hypoglycemic Agents; D010880:Piperidines; D011720:Pyrazoles; D008687:Metformin; D000077285:Rimonabant