title: The dual nature of Ets-1: focus to the pathogenesis of systemic lupus erythematosus.
abstract: E26 transformation-specific-1 (Ets-1) belongs to the Ets family of transcription factors which share a common 85-amino-acid DNA-binding domain. Ets-1 is essential to regulation of the immune system including immune cell proliferation and differentiation. Past data demonstrated Ets-1 play a role in negative regulation of Th17 cells and B cells differentiation. Recently, association of genetic variation in Ets-1 with susceptibility to systemic lupus erythematosus (SLE) have been independently identified by two Genome-wide association studies (GWAS), and decreased Ets-1mRNA level in peripheral blood mononuclear cells (PBMCs) of SLE patients has been reported. All these findings suggest that the transcription factor is broadly linked to the pathogenesis of this disease. However, aberrant control of other immune cells and effector molecules illuminated the complexities of Ets-1 biology. In this review article, we will focus on the dual nature of Ets-1 and discuss its regulatory capability. Hopefully the information obtained will lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China.
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Leng
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Gui-Mei
authors.initials: GM
authors.lastname: Chen
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Feng
authors.forename: Yin-Guang
authors.initials: YG
authors.lastname: Fan
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
authors.forename: Xiang-Pei
authors.initials: XP
authors.lastname: Li
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000639:trends; D006801:Humans; D056747:Immunomodulation; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D011110:Polymorphism, Genetic; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: C494041:ETS1 protein, human; D050784:Proto-Oncogene Protein c-ets-1