title: A database for the analysis of immunity genes in Drosophila: PADMA database.
abstract: While microarray experiments generate voluminous data, discerning trends that support an existing or alternative paradigm is challenging. To synergize hypothesis building and testing, we designed the Pathogen Associated Drosophila MicroArray (PADMA) database for easy retrieval and comparison of microarray results from immunity-related experiments (www.padmadatabase.org). PADMA also allows biologists to upload their microarray-results and compare it with datasets housed within PADMA. We tested PADMA using a preliminary dataset from Ganaspis xanthopoda-infected fly larvae, and uncovered unexpected trends in gene expression, reshaping our hypothesis. Thus, the PADMA database will be a useful resource to fly researchers to evaluate, revise, and refine hypotheses.
authors.affiliation: Biology Department, City College of New York, New York, NY, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Lee
authors.forename: Ariful
authors.initials: A
authors.lastname: Mondal
authors.forename: Chiyedza
authors.initials: C
authors.lastname: Small
authors.forename: Indira
authors.initials: I
authors.lastname: Paddibhatla
authors.forename: Akira
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: Shubha
authors.initials: S
authors.lastname: Govind
mesh_terms: D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D007113:Immunity, Innate / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D029721:Drosophila Proteins