title: [Ulipristal acetate: an emergency contraception extended to 5 days using a progesterone receptor modulator (Ellaone)].
abstract: Emergency contraception is a second chance for prevention of pregnancy after unprotected intercourse. Hormonal emergency contraception with levonorgestrel 1.5 mg, only provides an effective contraception from 0 to 72 hours after intercourse with decreasing effectiveness as time elapses. It was accordingly mandatory to develop an alternative approach with a stable contraceptive efficacy and good tolerance for 5 days, knowing additionally that the estimated lifespan of sperm in the female genital tract is about 5 days. In comparative studies bearing on more than 3000 young women, the progesterone receptor modulator (PRM) ulipristal acetate, a progesterone antagonist (taken in a single dose of 30 mg), or levonorgestrel (1.5 mg) were administered. Results indicated that the PRM was as effective as levonorgestrel, or even more, kept a stable efficacy for 120 hours after an unprotected intercourse, and was well tolerated. This establishes ulipristal acetate as the new standard for hormonal emergency contraception.
authors.affiliation: CHU de Liege, Policlinique Universitaire, Belgique. u.gaspard@chu.ulg.ac.be
authors.forename: U
authors.initials: U
authors.lastname: Gaspard
authors.forename: F
authors.initials: F
authors.lastname: Kridelka
mesh_terms: D044363:Contraception, Postcoital; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D005260:Female; D006801:Humans; D009649:Norpregnadienes / Q000494:pharmacology*
chemical_list: D003281:Contraceptives, Postcoital; D009649:Norpregnadienes; C555622:ulipristal acetate