title: New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus, Aspergillus versicolor LCJ-5-4.
abstract: Cottoquinazoline D (3), a new alkaloid with a 1-aminocyclopropane-1-carboxylic acid residue rarely discovered in nature, was isolated and identified together with two new quinazolinone alkaloids, cottoquinazolines B (1) and C (2), from coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures including absolute configurations were elucidated based on spectroscopic methods, X-ray single crystal diffraction analysis, and chemical methods. A possible biogenetic pathway for them was proposed.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Peoples' Republic of China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Xiancun
authors.initials: X
authors.lastname: Teng
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Li
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000598:Amino Acids, Cyclic / Q000737:chemistry*; D000818:Animals; D037421:Anthozoa / Q000382:microbiology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D007941:Leukemia P388; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000598:Amino Acids, Cyclic; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011799:Quinazolines; C557953:cottoquinazoline B; C557952:cottoquinazoline C; C557940:cottoquinazoline D; C023863:1-aminocyclopropane-1-carboxylic acid