title: Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy.
abstract: Chronic myelogenous leukemia (CML) is caused by the BCR-ABL1 fusion gene that encodes for a constitutively-active tyrosine kinase. Adults and children with CML are typically treated with imatinib mesylate, a BCR-ABL1 tyrosine kinase inhibitor (TKI), or a second-generation TKI. Several case reports have documented growth delay of unknown mechanism in children with CML treated with imatinib. We report a seven-year-old identical twin with CML who developed significant growth delay, as compared to her twin, during five years of TKI therapy. Detailed endocrine evaluation showed acquired growth hormone deficiency, a pathway potentially inhibited by TKIs.
authors.affiliation: Department of Pediatrics, The Children's Hospital, University of Colorado School of Medicine, Aurora, Colorado 80045, USA. hobernicht.susan@tchden.org
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hobernicht
authors.forename: Bahareh
authors.initials: B
authors.lastname: Schweiger
authors.forename: Philip
authors.initials: P
authors.lastname: Zeitler
authors.forename: Michael
authors.initials: M
authors.lastname: Wang
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Hunger
mesh_terms: D001549:Benzamides; D002648:Child; D000069439:Dasatinib; D004200:Diseases in Twins; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced*; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D013844:Thiazoles; D019382:Human Growth Hormone; D000068877:Imatinib Mesylate; D000069439:Dasatinib