title: Emerging trends in metalloprotein inhibition.
abstract: Numerous metalloproteins are important therapeutic targets that are gaining increased attention in the medicinal and bioinorganic chemistry communities. This Perspective article describes some emerging trends and recent findings in the area of metalloprotein inhibitor discovery and development. In particular, increasing recognition of the importance of the metal-ligand interactions in these systems calls for more input and consideration from the bioinorganic community to address questions traditionally confined to the medicinal chemistry community.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Rouffet
authors.forename: Seth M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D019747:Aldose-Ketose Isomerases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D000626:Aminopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008667:Metalloproteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D063208:Methionyl Aminopeptidases; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D011355:Prodrugs / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D008667:Metalloproteins; D009097:Multienzyme Complexes; D011355:Prodrugs; D010088:Oxidoreductases; C114231:1-deoxy-D-xylulose 5-phosphate reductoisomerase; D000626:Aminopeptidases; D063208:Methionyl Aminopeptidases; D019747:Aldose-Ketose Isomerases