title: Furosemide in the treatment of phosgene induced acute lung injury.
abstract: METHODS
  Using previously validated methods, 16 anaesthetised large white pigs were exposed to phosgene (target inhaled dose 0.3 mg kg(-1)), established on mechanical ventilation and randomised to treatment with either nebulised furosemide (4 ml of 10 mg x ml(-1) solution) or saline control. Treatments were given at 1, 3, 5, 7, 9, 12, 16 and 20 hours post phosgene exposure; the animals were monitored to 24 hours following phosgene exposure.
  
  
  RESULTS
  Furosemide treatment had no effect on survival, and had a deleterious effect on PaO2: FiO2 ratio between 19 and 24 hours. All other measures investigated were unaffected by treatment.
  
  
  CONCLUSIONS
  Nebulised furosemide treatment following phosgene induced acute lung injury does not improve survival and worsens PaO2: FiO2 ratio. Nebulised furosemide should be avoided following phosgene exposure.
authors.affiliation: Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, UK.
authors.forename: C
authors.initials: C
authors.lastname: Grainge
authors.forename: A J
authors.initials: AJ
authors.lastname: Smith
authors.forename: B J
authors.initials: BJ
authors.lastname: Jugg
authors.forename: S J
authors.initials: SJ
authors.lastname: Fairhall
authors.forename: T
authors.initials: T
authors.lastname: Mann
authors.forename: R
authors.initials: R
authors.lastname: Perrott
authors.forename: J
authors.initials: J
authors.lastname: Jenner
authors.forename: T
authors.initials: T
authors.lastname: Millar
authors.forename: P
authors.initials: P
authors.lastname: Rice
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D000280:Administration, Inhalation; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use*; D009330:Nebulizers and Vaporizers; D010084:Oxidation-Reduction / Q000187:drug effects; D010705:Phosgene; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D013552:Swine
chemical_list: D049994:Sodium Potassium Chloride Symporter Inhibitors; D010705:Phosgene; D005665:Furosemide