title: [Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population].
abstract: OBJECTIVE
  To investigate the relationship between the genetic polymorphisms of the six transmembrane protein of prostate 2 gene (STAMP2) and essential hypertension in Xinjiang Uygur population.
  
  
  METHODS
  The sequences of STAMP2 gene functional region were sequenced in Xinjiang Uygur population with hypertension. The representative variations selected were genotyped by TaqMan-PCR method in 2047 Uygur individuals, including 810 patients with hypertension and 1237 healthy subjects. The association of the genetic variations of the STAMP2 gene with hypertension in Uygur was analyzed.
  
  
  RESULTS
  In the three representative variations (rs8122, rs1981529 and rs34741656) genotyped, there were no significant differences in genotype distribution and allele frequencies between the essential hypertension and control groups (P > 0.05). In ANCOVA analysis, none of the polymorphisms was significantly associated with systolic blood pressure and diastolic blood pressure (P > 0.05). There were no significant differences in haplotype frequencies between the two groups either(P > 0.05).
  
  
  CONCLUSIONS
  There was no association of the three polymorphisms (rs8122, rs1981529 and rs34741656) in the STAMP2 gene with essential hypertension in Xinjiang Uygur population.
authors.affiliation: Department of Hypertension, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, 830001 PR China.
authors.forename: Yun-wei
authors.initials: YW
authors.lastname: Bi
authors.forename: Chang-min
authors.initials: CM
authors.lastname: Wang
authors.forename: Zhi-tao
authors.initials: ZT
authors.lastname: Yan
authors.forename: Nan-fang
authors.initials: NF
authors.lastname: Li
authors.forename: Yan-ying
authors.initials: YY
authors.lastname: Guo
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Yao
authors.forename: Deng-pan
authors.initials: DP
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D010088:Oxidoreductases / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D008565:Membrane Proteins; D010088:Oxidoreductases; C503310:STEAP4 protein, human