title: Kinase inhibition that hinges on halogen bonds.
abstract: A major challenge for the discovery of protein kinase inhibitors is to identify potent, selective, and novel pharmacophores. In this issue, Fedorov et al. (2011) describes KH-CB19, an ATP-competitive inhibitor of cdc2-like kinase that interacts with the ATP hinge region through a halogen-bonding motif.
authors.affiliation: Pfizer Oncology, Pfizer Worldwide R&D, 10777 Science Center Drive, San Diego, CA 92121, USA. stephan.grant@pfizer.com
authors.forename: Stephan K
authors.initials: SK
authors.lastname: Grant
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Lunney