title: Positive impact of HIV-1 gag cleavage site mutations on the virological response to darunavir boosted with ritonavir.
abstract: We assessed the roles of baseline gag and gag-pol cleavage site mutations (CSM) on the virological outcome of a darunavir-based regimen in highly antiretroviral-experienced patients. We showed the association, in multivariate analysis, between the A431V gag CSM and the virological response, defined as a reduction in plasma HIV-1 RNA to <50 copies/ml at month 3 (P = 0.028). Our results suggest that a specific gag CSM might have a role on protease inhibitor susceptibility in an inhibitor-specific manner.
authors.affiliation: AP-HP, Groupe Hospitalier Bichat-Claude Bernard, Laboratoire de Virologie, 75018 Paris, France.
authors.forename: Lucile
authors.initials: L
authors.lastname: Larrouy
authors.forename: Sidonie
authors.initials: S
authors.lastname: Lambert-Niclot
authors.forename: Charlotte
authors.initials: C
authors.lastname: Charpentier
authors.forename: Slim
authors.initials: S
authors.lastname: Fourati
authors.forename: Benoit
authors.initials: B
authors.lastname: Visseaux
authors.forename: Cathia
authors.initials: C
authors.lastname: Soulié
authors.forename: Marc
authors.initials: M
authors.lastname: Wirden
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Patrick
authors.initials: P
authors.lastname: Yeni
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
mesh_terms: D000069454:Darunavir; D015685:Fusion Proteins, gag-pol / Q000235:genetics*; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics; D009154:Mutation; D019438:Ritonavir / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D015685:Fusion Proteins, gag-pol; D017320:HIV Protease Inhibitors; D013449:Sulfonamides; D019438:Ritonavir; D000069454:Darunavir