title: Does waterborne citalopram affect the aggressive and sexual behaviour of rainbow trout and guppy?
abstract: Citalopram is one of several selective serotonin reuptake inhibitors (SSRIs) commonly found in treated sewage effluents. Accordingly, there are concerns about possible adverse effects of SSRIs on aquatic organisms, particularly behavioural effects similar to those associated with SSRI use in humans. Rainbow trout fry and adult male guppies were therefore exposed to waterborne citalopram, ranging from environmentally relevant to high concentrations (1, 10, 100 μg/L) for 3-7 days. Under these experimental conditions citalopram does not appear to cause significant effects on aggression in rainbow trout fry or on sexual behaviour in male guppies. This may be explained by a relatively low uptake of citalopram from water to fish.
authors.affiliation: Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Box 434, SE-405 30 Göteborg, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Holmberg
authors.forename: Jenny
authors.initials: J
authors.lastname: Fogel
authors.forename: Eva
authors.initials: E
authors.lastname: Albertsson
authors.forename: Jerker
authors.initials: J
authors.lastname: Fick
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Brown
authors.forename: Nicklas
authors.initials: N
authors.lastname: Paxéus
authors.forename: Lars
authors.initials: L
authors.lastname: Förlin
authors.forename: Jörgen I
authors.initials: JI
authors.lastname: Johnsson
authors.forename: D G Joakim
authors.initials: DG
authors.lastname: Larsson
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000818:Animals; D015283:Citalopram / Q000633:toxicity*; D005260:Female; D017686:Oncorhynchus mykiss / Q000502:physiology*; D011036:Poecilia / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000633:toxicity*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors; D014874:Water Pollutants, Chemical