title: Correlation between stated and measured concentrations of acrylate and methacrylate allergens in patch-test preparations.
abstract: BACKGROUND
  Contact allergy to acrylates and methacrylates is not uncommon. The allergy is confirmed by patch-testing patients with commercial patch-test preparations.
  
  
  OBJECTIVE
  To investigate acrylate and methacrylate allergens used for patch testing in nine different dermatology departments from Europe, America, Asia, and Australia.
  
  
  METHODS
  The acrylate and methacrylate (methyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, and triethylene glycol diacrylate) allergen samples were analyzed with high-performance liquid chromatography to measure the allergen content.
  
  
  RESULTS
  Variation in measured versus stated concentrations was seen in these samples. The ratio of measured to stated concentrations ranged from 0.11 to 1.1. Only 22 (63%) of 35 samples were within the arbitrary acceptable limits of 80 to 120% of the stated concentrations.
  
  
  CONCLUSIONS
  The results may have implications for individual diagnosis and prevention and when test results from various centers are compared.
authors.affiliation: Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden. anthonygoon@nsc.gov.sg
authors.forename: Anthony Teik-Jin
authors.initials: AT
authors.lastname: Goon
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
authors.forename: Erik
authors.initials: E
authors.lastname: Zimerson
authors.forename: Osten
authors.initials: O
authors.lastname: Sörensen
authors.forename: Chee-Leok
authors.initials: CL
authors.lastname: Goh
authors.forename: David Soo-Quee
authors.initials: DS
authors.lastname: Koh
authors.forename: Marléne
authors.initials: M
authors.lastname: Isaksson
mesh_terms: D000485:Allergens / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003877:Dermatitis, Contact / Q000175:diagnosis*; D006801:Humans; D008689:Methacrylates / Q000032:analysis* / Q000592:standards*; D010328:Patch Tests / Q000592:standards*
chemical_list: D000485:Allergens; D008689:Methacrylates