title: [Epidemiology of healthcare-associated infections due to MRSA in Brest University Hospital from 2004 to 2007. Impact of hydroalcoholic gel and antibiotics consumptions].
abstract: The fight against healthcare-associated infections is based on preventive measures of multidrug resistant bacteria diffusion. Hand hygiene is the simplest and the most effective preventive measure to reduce cross-transmission of infectious agents. Hydroalcoholic solutions for hand hygiene was recently introduced in the University Hospital of Brest (France). The aims of the study were: to describe the epidemiology of healthcare-associated infections due to methicillin-resistant Staphylococcus aureus (MRSA); to determine the annual consumptions of antistaphylococcal antibiotics; and to discuss the relation between consumption of antiseptic products or antibiotics and the epidemiology of MRSA.
  
  
  METHODS
  A retrospective epidemiological and pharmaco-epidemiological study was realized from January 2004 to December 2007 in the University Hospital of Brest (France). It allowed to bring to light the cases of healthcare-associated infections due to MRSA and to quantify the consumptions of hang hygiene products and antistaphylococcal antibiotics.
  
  
  RESULTS
  this retrospective study showed a decrease of healthcare-associated infections due to MRSA and an increase of the consumption of hydroalcoholic solutions. Antistaphylococcal resistance rates also decreased in a context of fall of the global antibiotics consumption in the hospital.
authors.affiliation: Laboratoire d'hygiène hospitalière, service de santé publique, CHU de Brest, université de Bretagne Occidentale, 29609 Brest, France. nicolas.rouzic@chu-brest.fr
authors.forename: N
authors.initials: N
authors.lastname: Rouzic
authors.forename: D
authors.initials: D
authors.lastname: Tande
authors.forename: C
authors.initials: C
authors.lastname: Payan
authors.forename: B
authors.initials: B
authors.lastname: Garo
authors.forename: M
authors.initials: M
authors.lastname: Garre
authors.forename: B
authors.initials: B
authors.lastname: Lejeune
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission; D004202:Disinfectants / Q000494:pharmacology*; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D005782:Gels; D006235:Hand Disinfection; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D008875:Middle Aged; D011206:Povidone-Iodine / Q000494:pharmacology; D012189:Retrospective Studies; D012915:Soaps / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control / Q000635:transmission
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004202:Disinfectants; D005782:Gels; D012915:Soaps; D011206:Povidone-Iodine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine