title: Unilateral visual loss due to ischaemic injury in the right calcarine region: a functional magnetic resonance imaging and diffusion tension imaging follow-up study.
abstract: To study the functional recovery of a patient with cerebrovascular injury using combined functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI). A 24-year-old woman with left hemianopsia underwent fMRI and DTI in a 1.5-tesla machine both in the acute phase and 1 month after an ischaemic stroke involving the right calcarine cortex. Acute-phase fMRI demonstrated that peripheral left visual field stimulation did not activate the right primary visual cortex, whereas stimulation 1 month later activated the visual cortex bilaterally. Analysis of acute-phase DTI data disclosed that a reduction of fractional anisotropy in the right optic radiation had almost resolved after 1 month. Fibre direction was normal at either time point. fMRI and DTI can demonstrate functional damage and recovery in patients with neuro-ophthalmological lesions.
authors.affiliation: Sezione Scienze Radiologiche, Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Università Politecnica delle Marche, Ancona, Italy, g.polonara@univpm.it
authors.forename: Gabriele
authors.initials: G
authors.lastname: Polonara
authors.forename: Simone
authors.initials: S
authors.lastname: Salvolini
authors.forename: Mara
authors.initials: M
authors.lastname: Fabri
authors.forename: Giulia
authors.initials: G
authors.lastname: Mascioli
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Cavola
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Neri
authors.forename: Cesare
authors.initials: C
authors.lastname: Mariotti
authors.forename: Alfonso
authors.initials: A
authors.lastname: Giovannini
authors.forename: Ugo
authors.initials: U
authors.lastname: Salvolini
mesh_terms: D016880:Anisotropy; D002545:Brain Ischemia / Q000150:complications* / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005500:Follow-Up Studies; D006423:Hemianopsia / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D010775:Photic Stimulation; D020127:Recovery of Function; D013997:Time Factors; D014786:Vision Disorders / Q000209:etiology* / Q000503:physiopathology; D014793:Visual Cortex / Q000098:blood supply*; D058609:Visual Field Tests; D014794:Visual Fields; D055815:Young Adult