title: Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation.
abstract: Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.
authors.affiliation: Department of Oceanography, Kunsan National University, Jeonbuk, Korea. jrrho@kunsan.ac.kr
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
authors.forename: Buyng Su
authors.initials: BS
authors.lastname: Hwang
authors.forename: Seewon
authors.initials: S
authors.lastname: Joung
authors.forename: Mi Ran
authors.initials: MR
authors.lastname: Byun
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Hong
authors.forename: Hee-Yoon
authors.initials: HY
authors.lastname: Lee
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism*; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D054830:Sesterterpenes; C557672:phorbasone A; C557673:phorbasone B; D002118:Calcium