title: Pulmonary artery stenosis secondary to fibrosing mediastinitis: management with cutting balloon angioplasty and endovascular stenting.
abstract: Cutting balloon angioplasty is a common treatment modality in the pediatric population for pulmonary artery stenosis. We present an adult with histoplasmosis induced fibrosing mediastinitis resulting in pulmonary artery stenosis that was successfully treated with cutting balloon angioplasty and subsequent stent deployment. Percutaneous endovascular stent placement has be shown to effectively alleviate pulmonary artery stenosis, however in-stent restenosis does limit durability. Pharmacologic therapy is indicated with either mediastinal adenitis or mediastinal granuloma with anti-fungal agents such as amphotericin B and itraconazole. Surgical intervention for histoplasmosis induced fibrosing mediastinitis is rarely indicated and may result in fatal complications that stem from mediastinal fibrosis due to resultant destruction of surgical planes. To our knowledge, this is the first reported case of utilizing cutting balloon angioplasty and stent insertion for the treatment of histoplasmosis induced fibrosing mediastinitis complicated by pulmonary artery stenosis.
authors.affiliation: Department of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Colombus, OH 43205, USA. j.shaun.smith@osumc.edu
authors.forename: J Shaun
authors.initials: JS
authors.lastname: Smith
authors.forename: Steven
authors.initials: S
authors.lastname: Kadiev
authors.forename: Phillip
authors.initials: P
authors.lastname: Diaz
authors.forename: John
authors.initials: J
authors.lastname: Cheatham
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon / Q000295:instrumentation*; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D003251:Constriction, Pathologic; D005260:Female; D006660:Histoplasmosis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008480:Mediastinitis / Q000175:diagnosis / Q000209:etiology; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000473:pathology; D012598:Sclerosis / Q000175:diagnosis / Q000209:etiology; D015607:Stents; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome