title: Improvement of nonbullous congenital ichthyosiform erythroderma following functional endoscopic sinus surgery.
abstract: We report the case of a child with congenital nonbullous ichthyosiform erythroderma on long-term isotretinoin who developed progressively worsening ichthyosis along with recurrent bouts of sinusitis. Endoscopic sinus surgery revealed osteophytes, most likely an isotretinoin-related adverse event, and post operatively the patient's sinus disease and skin disease both dramatically improved. This case represents the first report, to our knowledge, of ichthyosis improving after endoscopic sinus surgery.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA.
authors.forename: Julie S
authors.initials: JS
authors.lastname: Green
authors.forename: Thomas
authors.initials: T
authors.lastname: Donovan
authors.forename: Elaine C
authors.initials: EC
authors.lastname: Siegfried
mesh_terms: D002648:Child; D002908:Chronic Disease; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004724:Endoscopy; D006261:Headache / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D015576:Hyperostosis / Q000139:chemically induced; D017490:Ichthyosis, Lamellar / Q000188:drug therapy / Q000601:surgery*; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D054850:Osteophyte / Q000139:chemically induced; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000601:surgery; D011859:Radiography; D012852:Sinusitis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin