title: Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni.
abstract: Trioxaquine PA1259 is an efficient drug on larval- and adult-stage schistosomes, able to alkylate heme inside worms treated with it, leading to the formation of covalent heme-drug adducts. Such a mechanism, similar to one reported for other trioxaquines in Plasmodium, indicates that heme may be a common target of these trioxane-based drugs in different blood-feeding parasites.
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Pradines
authors.forename: Julien
authors.initials: J
authors.lastname: Portela
authors.forename: Jérôme
authors.initials: J
authors.lastname: Boissier
authors.forename: Frédéric
authors.initials: F
authors.lastname: Coslédan
authors.forename: Bernard
authors.initials: B
authors.lastname: Meunier
authors.forename: Anne
authors.initials: A
authors.lastname: Robert
mesh_terms: D000478:Alkylation; D000818:Animals; D000871:Anthelmintics / Q000378:metabolism / Q000627:therapeutic use*; D006418:Heme / Q000378:metabolism*; D051379:Mice; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000378:metabolism* / Q000472:pathogenicity; D012555:Schistosomiasis mansoni / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D006418:Heme