title: Peroxisome proliferator-activated receptor γ regulates angiotensin II-induced catalase downregulation in adventitial fibroblasts of rats.
abstract: Peroxisome proliferator-activated receptor (PPAR) γ ligands oppose the effect induced by angiotensin II (Ang II) to reduce oxidative stress and improve antioxidant status. In this study, Ang II inhibited catalase (CAT) and peroxisome proliferator-activated receptor γ (PPAR γ) protein and mRNA expressions. Transfection with PPAR γ small-interfering RNA (siRNA) led to a reduction in CAT expression. PPAR γ ligands enhanced CAT expression and inhibited extracellular signal-regulated kinase 1/2 activation. We further reveal that Ang II type 1 receptor is not involved in the inhibitory effects of PPAR γ ligands on Ang II stimulatory events.
authors.affiliation: Division of Geriatrics, RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Yang
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.forename: Haiya
authors.initials: H
authors.lastname: Wang
authors.forename: Weili
authors.initials: W
authors.lastname: Shen
authors.forename: Pingjin
authors.initials: P
authors.lastname: Gao
authors.forename: Manpreet
authors.initials: M
authors.lastname: Singh
authors.forename: Ningyuan
authors.initials: N
authors.lastname: Fang
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002374:Catalase / Q000235:genetics* / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism*; D015536:Down-Regulation / Q000187:drug effects*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology*; D008024:Ligands; D008297:Male; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D008024:Ligands; D047495:PPAR gamma; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; D002374:Catalase; D048049:Extracellular Signal-Regulated MAP Kinases