title: Catalytic asymmetric conjugate addition of Grignard reagents to coumarins--synthesis of versatile chiral building blocks.
abstract: A new protocol for the Cu-catalysed asymmetric conjugate addition of Grignard reagents to coumarins has been developed. The corresponding products are formed in high yields and enantioselectivities. Through a sequential protocol involving conjugate addition followed by nucleophilic ring opening of the chiral enolate, chiral esters and amides are readily accessible.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Teichert
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa