title: Quantification of aortic regurgitant fraction and volume with multi-detector computed tomography comparison with echocardiography.
abstract: OBJECTIVE
  Evaluate quantification of the aortic regurgitant fraction and volume with computed tomography (CT).
  
  
  METHODS
  Fifty-three patients with aortic regurgitation (AR) and 29 controls were examined with 64-multi-detector CT coronary angiography and transthoracic echocardiography (TTE). A dedicated software algorithm employing three-dimensional segmentation of left ventricle (LV) and right ventricle (RV) volumes and LV mass was applied. AR volume and fraction was calculated based on RV and LV stroke volumes (SV) and compared with echocardiography. The aortic regurgitant orifice area (ROA) was measured by CT.
  
  
  RESULTS
  A good correlation of the AR fraction and AR volume determined by CT compared to echocardiography was found for mild, moderate, and severe AR with 14.2% ± 9, 28.8% ± 8, and 57.9% ± 9 (r = 0.95, P < .001) for AR fraction, and 15.7 mL ± 11.33 mL ± 14, and 98.9 mL ± 36 for AR volume (r = 0.92, P < .0001), respectively. CT correctly classified severity of AR in 93% of patients based of AR-fraction, and in 89% based on AR volume. The sensitivity and specificity of CT were 98% and specificity 90.3%. The specificity improved to 97%, if the ROA by CT was added as diagnostic criterion.
  
  
  CONCLUSIONS
  Aortic regurgitation fraction and volume can be accurately quantified from CT coronary angiography datasets. These parameters can assist clinical management, e.g. in case of pending cardiac surgery decision.
authors.affiliation: Department of Radiology II, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. Gudrun.Feuchtner@i-med.ac.at
authors.forename: Gudrun M
authors.initials: GM
authors.lastname: Feuchtner
authors.forename: Alexander
authors.initials: A
authors.lastname: Spoeck
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lessick
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dichtl
authors.forename: Andrè
authors.initials: A
authors.lastname: Plass
authors.forename: Sebastian
authors.initials: S
authors.lastname: Leschka
authors.forename: Silvana
authors.initials: S
authors.lastname: Mueller
authors.forename: Andrea
authors.initials: A
authors.lastname: Klauser
authors.forename: Hans
authors.initials: H
authors.lastname: Scheffel
authors.forename: Florian
authors.initials: F
authors.lastname: Wolf
authors.forename: Werner
authors.initials: W
authors.lastname: Jaschke
authors.forename: Hatem
authors.initials: H
authors.lastname: Alkadhi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000000981:diagnostic imaging*; D001022:Aortic Valve Insufficiency / Q000175:diagnosis*; D001027:Aortography / Q000379:methods*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*