title: Genetic association of Fc receptor-like 3 polymorphisms with susceptibility to primary biliary cirrhosis: ethnic comparative study in Japanese and Italian patients.
abstract: A functional variant in the Fc receptor-like 3 (FCRL3) gene is associated with the susceptibility to several autoimmune diseases. In this study, we examined whether the FCRL3 is associated with susceptibility to primary biliary cirrhosis (PBC) by comparing the two different ethnic groups, Japanese and Italians. We enrolled 232 patients with PBC and 230 controls in Japanese, and 216 PBC and 180 controls in Italians. Minor allele frequency of fcrl3_3 (-169 T>C) in the patients with PBC and controls was 0.20 and 0.09 in Japanese and 0.24 and 0.21 in Italians, respectively. We found a significant association of fcrl3_3 with PBC only in Japanese (P = 9.64 × 10(-7) ). These findings support the presence of common FCRL3-related pathological pathways in several autoimmune diseases, especially in Asians.
authors.affiliation: Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan. a-tanaka@med.teikyo-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Ohira
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: S
authors.initials: S
authors.lastname: Nezu
authors.forename: A
authors.initials: A
authors.lastname: Shibuya
authors.forename: I
authors.initials: I
authors.lastname: Bianchi
authors.forename: M
authors.initials: M
authors.lastname: Podda
authors.forename: P
authors.initials: P
authors.lastname: Invernizzi
authors.forename: H
authors.initials: H
authors.lastname: Takikawa
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D001327:Autoimmune Diseases / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007558:Italy; D008105:Liver Cirrhosis, Biliary / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic