title: Sonography-guided percutaneous microwave ablation of intrahepatic primary cholangiocarcinoma.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of sonography-guided percutaneous microwave ablation of intrahepatic primary cholangiocarcinoma.
  
  
  METHODS
  From May 2006 to March 2010, 15 patients (11 men, 4 women; mean age, 57.4 years) with 24 histologically proven intrahepatic primary cholangiocarcinoma lesions (mean tumor size, 3.2±1.9 cm; range, 1.3-9.9 cm) were treated with microwave ablation.
  
  
  RESULTS
  Thirty-eight sessions were performed for 24 nodules in 15 patients. The follow-up period was 4-31 months (mean, 12.8±8.0 months). The ablation success rate, the technique effectiveness rate, and the local tumor progression rate were 91.7% (22/24), 87.5% (21/24), and 25% (6/24) respectively according to the results of follow-up. The cumulative overall 6, 12, 24 month survival rates were 78.8%, 60.0%, and 60.0%, respectively. Major complication occurred including liver abscess in two patients (13.3%) and needle seeding in one patient (6.7%). Both complications were cured satisfied with antibiotic treatment combined to catheter drainage for abscess and resection for needle seeding. The minor complications and side effects were experienced by most patients which subsided with supportive treatment.
  
  
  CONCLUSIONS
  Microwave ablation can be used as a safe and effective technique to treat intrahepatic primary cholangiocarcinoma.
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 China.
authors.forename: Ming-An
authors.initials: MA
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Yu
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Cheng
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Han
authors.forename: Fang-Yi
authors.initials: FY
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
mesh_terms: D000038:Abscess / Q000453:epidemiology; D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D017115:Catheter Ablation / Q000295:instrumentation*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000601:surgery*; D018450:Disease Progression; D004322:Drainage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D009366:Neoplasm Seeding; D011183:Postoperative Complications / Q000453:epidemiology; D015996:Survival Rate; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional