title: Hepatitis E virus and neurologic disorders.
abstract: Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging. During 2004-2009, at 2 hospitals in the United Kingdom and France, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7 (5.5%): inflammatory polyradiculopathy (n = 3), Guillain-Barre syndrome (n = 1), bilateral brachial neuritis (n = 1), encephalitis (n = 1), and ataxia/proximal myopathy (n = 1). Three cases occurred in nonimmunocompromised patients with acute HEV infection, and 4 were in immunocompromised patients with chronic HEV infection. HEV RNA was detected in cerebrospinal fluid of all 4 patients with chronic HEV infection but not in that of 2 patients with acute HEV infection. Neurologic outcomes were complete resolution (n = 3), improvement with residual neurologic deficit (n = 3), and no improvement (n = 1). Neurologic disorders are an emerging extrahepatic manifestation of HEV infection.
authors.affiliation: Department of Nephrology, Dialysis and Organ Transplantation, Centre Hospitalier Universitaire Rangueil, Toulouse, France. kamar.n@chu-toulouse.fr
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Richard P
authors.initials: RP
authors.lastname: Bendall
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Peron
authors.forename: Pascal
authors.initials: P
authors.lastname: Cintas
authors.forename: Laurent
authors.initials: L
authors.lastname: Prudhomme
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Mansuy
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
authors.forename: Frances
authors.initials: F
authors.lastname: Keane
authors.forename: Samreen
authors.initials: S
authors.lastname: Ijaz
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
authors.forename: Harry R
authors.initials: HR
authors.lastname: Dalton
mesh_terms: D000208:Acute Disease; D000328:Adult; D002908:Chronic Disease; D005260:Female; D005602:France; D020275:Guillain-Barre Syndrome / Q000503:physiopathology / Q000821:virology*; D016751:Hepatitis E / Q000150:complications* / Q000821:virology; D016752:Hepatitis E virus / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000503:physiopathology / Q000821:virology*; D006113:United Kingdom