title: Immunity to seasonal and pandemic influenza A viruses.
abstract: The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain.
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Royal Pde, Parkville 3010, Melbourne, Australia.
authors.forename: Sophie A
authors.initials: SA
authors.lastname: Valkenburg
authors.forename: John A
authors.initials: JA
authors.lastname: Rutigliano
authors.forename: Ali H
authors.initials: AH
authors.lastname: Ellebedy
authors.forename: Peter C
authors.initials: PC
authors.lastname: Doherty
authors.forename: Paul G
authors.initials: PG
authors.lastname: Thomas
authors.forename: Katherine
authors.initials: K
authors.lastname: Kedzierska
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D009980:Influenza A virus / Q000145:classification / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology; D051379:Mice; D058873:Pandemics; D012621:Seasons
chemical_list: D000914:Antibodies, Viral