title: Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma.
abstract: Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and stemness features. The association between MPM histologies and genes expression were explored using active and passive Principal Components Analysis-based biplots and PAM analysis that provided evidence that with respect to normal tissues, MPMs histologies were better characterized by specific patterns of expression of genes involved in EMT activation, cell polarity and stemness.
authors.affiliation: Department of Life Sciences, University of Trieste, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Casarsa
authors.forename: Niccolò
authors.initials: N
authors.lastname: Bassani
authors.forename: Federico
authors.initials: F
authors.lastname: Ambrogi
authors.forename: Giuliano
authors.initials: G
authors.lastname: Zabucchi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Boracchi
authors.forename: Elia
authors.initials: E
authors.lastname: Biganzoli
authors.forename: Danila
authors.initials: D
authors.lastname: Coradini
mesh_terms: D016764:Cell Polarity; D004847:Epithelial Cells / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D008654:Mesothelioma / Q000473:pathology*; D010997:Pleural Neoplasms / Q000473:pathology*