title: Antimicrobial resistance among clinical isolates of Staphylococcus aureus in Thailand from 2000 to 2005.
abstract: From 2000 to 2005, the data of all clinical isolates of Staphylococcus aureus including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) from 28 hospitals in the National Antimicrobial Resistance Surveillance, Thailand (NARST) program were reviewed and analyzed for the prevalence and pattern of antimicrobial susceptibility by WHONET software program. Among all isolates, around 26% of MRSA have been noted in each year The rates of erythromycin-resistant MRSA were relatively high, ranging from 94.5% to 96.8%, followed by clindamycin resistant (37.4% to 68.9%), fosfomycin-resistant (7.7% to 17%), vancomycin-resistant (0.1% to 0.8%), and teicoplanin resistant (0.2% to 1.3%). The rates of antimicrobial resistance MSSA were constantly low, with erythromycin resistance ranging from 3.7% to 4.6%, clindamycin resistance ranging from 1.4% to 2.3%, fosfomycin resistance ranging from 0.7% to 1.4%, vancomycin resistance ranging from 0.1% to 1.2%, and teicoplanin resistance ranging from 0.1% to 1.1%. An increasing trend of vancomycin resistance in S. aureus determined by the disk diffusion method should be further confirmed by appropriate susceptibility methods. Molecular typing methods are needed to determine the epidemiological association between these resistant isolates.
authors.affiliation: National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
authors.forename: Prapawadee
authors.initials: P
authors.lastname: Tishyadhigama
authors.forename: Surang
authors.initials: S
authors.lastname: Dejsirilert
authors.forename: Orathai
authors.initials: O
authors.lastname: Thongmali
authors.forename: Pathom
authors.initials: P
authors.lastname: Sawanpanyalert
authors.forename: Nalinee
authors.initials: N
authors.lastname: Aswapokee
authors.forename: Dadanabhand
authors.initials: D
authors.lastname: Piboonbanakit
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D015995:Prevalence; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D013785:Thailand / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents