title: An electrifying iPSC disease model: long QT syndrome type 2 and heart cells in a dish.
abstract: In a recent Nature paper, Itzhaki et al. (2011) generate induced pluripotent stem cells (iPSCs) from patients with a potentially fatal inherited arrhythmia, long QT syndrome type 2. Cardiomyocytes differentiated from the patient-derived iPSCs exhibit the hallmark cardiac electrical signatures of the disease, which can be reversed by pharmacological intervention.
authors.affiliation: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Clinical Science Center, 600 Highland Avenue, Madison, WI 53792-3248 USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kamp
mesh_terms: D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000473:pathology; D008133:Long QT Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000378:metabolism