title: Early detection and intervention evaluation for people at high-risk of psychosis-2 (EDIE-2): trial rationale, design and baseline characteristics.
abstract: OBJECTIVE
  Much research has begun to focus on the identification of people who are at high risk of developing psychosis, and clinical services have been initiated for this population. However, only a small number of studies have reported on the efficacy of interventions for preventing or delaying the onset of psychosis. The results of prior work suggest that cognitive therapy (CT) may be an effective, well-tolerated treatment. We report on the rationale and design for a large-scale, multi-site randomized, controlled trial of CT for people who are assessed to be at high risk of psychosis because of either state or state-plus-trait risk factors.
  
  
  METHODS
  The study employs a single-blind design in which all participants receive frequent mental-state monitoring, which will efficiently detect transition to psychosis, and half are randomized to weekly sessions of CT for up to 6 months. Participants will be followed-up for a minimum of 12 months and to a maximum of 2 years.
  
  
  RESULTS
  We report the characteristics of the final sample at baseline (n=288).
  
  
  CONCLUSIONS
  Our study aimed to expand the currently limited evidence base for best practice in interventions for individuals at high risk of psychosis.
authors.affiliation: School of Psychological Sciences, University of Manchester, Manchester, UK. anthony.p.morrison@manchester.ac.uk
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Morrison
authors.forename: Suzanne L K
authors.initials: SL
authors.lastname: Stewart
authors.forename: Paul
authors.initials: P
authors.lastname: French
authors.forename: Richard P
authors.initials: RP
authors.lastname: Bentall
authors.forename: Max
authors.initials: M
authors.lastname: Birchwood
authors.forename: Rory
authors.initials: R
authors.lastname: Byrne
authors.forename: Linda M
authors.initials: LM
authors.lastname: Davies
authors.forename: David
authors.initials: D
authors.lastname: Fowler
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Gumley
authors.forename: Peter B
authors.initials: PB
authors.lastname: Jones
authors.forename: Shôn W
authors.initials: SW
authors.lastname: Lewis
authors.forename: Graham K
authors.initials: GK
authors.lastname: Murray
authors.forename: Paul
authors.initials: P
authors.lastname: Patterson
authors.forename: Graham
authors.initials: G
authors.lastname: Dunn
mesh_terms: D000293:Adolescent; D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003625:Data Collection / Q000379:methods*; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000628:therapy*