title: Synthesis of fluorescent probes based on the pyochelin siderophore scaffold.
abstract: Pyochelin is a siderophore common to several pathogenic bacterial strains. Two conjugates, 1 and 2, between the NBD (4-nitro-benzo[1,2,5]oxadiazole) fluorophore and an N3''-functionalized pyochelin were synthesized. These fluorescent probes unexpectedly increased their fluorescence in an aqueous medium in the presence of iron(III) and were transported into bacterial cells.
authors.affiliation: UMR 7242 Biotechnologie et Signalisation Cellulaire, Université de Strasbourg-CNRS, ESBS, Illkirch, France.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Noël
authors.forename: Laurent
authors.initials: L
authors.lastname: Guillon
authors.forename: Isabelle J
authors.initials: IJ
authors.lastname: Schalk
authors.forename: Gaëtan L A
authors.initials: GL
authors.lastname: Mislin
mesh_terms: D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D017262:Siderophores / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D010636:Phenols; D017262:Siderophores; D013844:Thiazoles; C025316:pyochelin