title: Codon adaptation-based control of protein expression in C. elegans.
abstract: We present a method to control protein levels under native genetic regulation in Caenorhabditis elegans by using synthetic genes with adapted codons. We found that the force acting on the spindle in C. elegans embryos was related to the amount of the G-protein regulator GPR-1/2. Codon-adapted versions of any C. elegans gene can be designed using our web tool, C. elegans codon adapter.
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Redemann
authors.forename: Siegfried
authors.initials: S
authors.lastname: Schloissnig
authors.forename: Susanne
authors.initials: S
authors.lastname: Ernst
authors.forename: Andrey
authors.initials: A
authors.lastname: Pozniakowsky
authors.forename: Swathi
authors.initials: S
authors.lastname: Ayloo
authors.forename: Antony A
authors.initials: AA
authors.lastname: Hyman
authors.forename: Henrik
authors.initials: H
authors.lastname: Bringmann
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D002455:Cell Division / Q000235:genetics; D003062:Codon / Q000235:genetics*; D005786:Gene Expression Regulation; D005821:Genetic Techniques; D014176:Protein Biosynthesis / Q000235:genetics*
chemical_list: D029742:Caenorhabditis elegans Proteins; D003062:Codon; C475458:G protein regulator 1, C elegans; C475459:G protein regulator 2, C elegans