title: Diabetes mellitus is associated with shortened activated partial thromboplastin time and increased fibrinogen values.
abstract: OBJECTIVE
  This study was designed to examine the relationship between shortened activated partial thromboplastin time (APTT) and increased fibrinogen values with diabetes mellitus.
  
  
  METHODS
  APTT, prothrombin time (PT), fibrinogen, fasting plasma glucose (FPG) and glycosylated hemoglobin A1c (HbA1c) levels were measured in 1,300 patients. Patients were divided into three groups according to their HbA1c and FPG levels.
  
  
  RESULTS
  When participants were grouped according to their HbA1c levels, we found significantly shorter APTT values (26.9±5.6 s) and increased fibrinogen levels (3.1, 1.9-6.3 g/L) in the diabetes group when compared with the other two groups. When participants were grouped according to their FPG levels, we found significantly shorter APTT values (26.9±6.2 s) and increased fibrinogen levels (3.1, 1.8-6.2 g/L) in the diabetes group when compared with the euglycemic group.
  
  
  CONCLUSIONS
  Shorter APTT and increased fibrinogen levels might be useful hemostatic markers in patients with diabetes and in patients at high risk for diabetes.
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Juanwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Jianping
authors.initials: J
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006442:Glycated Hemoglobin / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time
chemical_list: D001786:Blood Glucose; D005340:Fibrinogen; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human