title: Influence of different generations of poly(propylene imine) dendrimers on human erythrocytes.
abstract: The unique characteristics of dendrimers make them attractive candidates as drug carriers. However, the toxicity associated with dendrimers is a basic hurdle in their biomedical application. To ensure development of dendrimer based safe and effective delivery systems, the effect of dendrimers on human erythrocytes (RBCs) must be studied. The present study explores the toxicological behavior of different generations of poly(propylene imine) dendrimers on human RBCs. Plain fifth generation PPI dendrimers (1 mg/mL) showed approximately 6.39% hemolysis which was an indication of their suitability in drug delivery. The study was conducted on all generations from 0.5 to 5.0 G of PPI dendrimers.
authors.affiliation: Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr H. S. Gour University, Sagar M P, India.
authors.forename: V
authors.initials: V
authors.lastname: Mishra
authors.forename: U
authors.initials: U
authors.lastname: Gupta
authors.forename: N K
authors.initials: NK
authors.lastname: Jain
mesh_terms: D002626:Chemistry, Pharmaceutical; D050091:Dendrimers / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems; D004907:Erythrocyte Deformability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005079:Excipients; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D011126:Polypropylenes / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties
chemical_list: D050091:Dendrimers; D005079:Excipients; D006454:Hemoglobins; D011126:Polypropylenes; C443641:poly(propyleneimine)