title: Structural biology of TRP channels.
abstract: Structural studies on TRP channels, while limited, are poised for a quickened pace and rapid expansion. As of yet, no high-resolution structure of a full length TRP channel exists, but low-resolution electron cryomicroscopy structures have been obtained for 4 TRP channels, and high-resolution NMR and X-ray crystal structures have been obtained for the cytoplasmic domains, including an atypical protein kinase domain, ankyrin repeats, coiled coil domains and a Ca(2+)-binding domain, of 6 TRP channels. These structures enhance our understanding of TRP channel assembly and regulation. Continued technical advances in structural approaches promise a bright outlook for TRP channel structural biology.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY, 10027, USA, ml2311@columbia.edu.
authors.forename: Minghui
authors.initials: M
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D018360:Crystallography, X-Ray; D008854:Microscopy, Electron; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D011487:Protein Conformation; D050051:Transient Receptor Potential Channels / Q000737:chemistry*
chemical_list: D050051:Transient Receptor Potential Channels