title: [Uterine fibroid embolization in women with giant fibroids].
abstract: OBJECTIVE
  to evaluate the effectiveness of uterine fibroid embolization (UFE) in patients with giant fibroids, with regard to both clinical outcomes and size reduction.
  
  
  METHODS
  twenty-six patients with a mean age of 36.5 years, carrying symptomatic fibroids with a volume over 1,000 cm³, were referred for UFE. All patients had indication for percutaneous treatment. The procedures were performed under epidural anesthesia and sedation, using an institutional protocol. By unilateral femoral access, selective catheterization of uterine arteries and infusion of calibrated microspheres through microcatheter were carried out. Clinical evaluation was performed by means of regular outpatient gynecology consultation. All patients underwent magnetic resonance imaging (MRI) before the procedure and 15 patients underwent control MRI after 6 months.
  
  
  RESULTS
  technical success was 100%. There was no complication related to the procedures. Mean uterine volume of the 15 patients studied was 1,401 cm³ before embolization (min 1,045 cm³, max 2,137 cm³) and 799 cm³ after 6 months (525 cm³ min, max. 1,604 cm³), resulting in a total reduction of 42.9%. Clinical improvement was observed in 25 of 26 patients. One woman with uterine volume of 1,098 cm³ who developed necrosis and partial fibroid expulsion underwent myomectomy. Another patient was submitted to myomectomy six months after the procedure because she wanted to become pregnant, despite partial fibroid size reduction. One patient with a uterine volume of 2,201 cm³ required a second intervention to achieve an adequate angiographic result. No patient underwent hysterectomy. On average, 9.2 microsphere syringes were used per patient.
  
  
  CONCLUSIONS
  embolization of giant uterine fibroids is a feasible procedure with acceptable clinical and radiological outcomes. It can be considered an option for patients who desire to preserve the uterus, and it may serve as adjuvant therapy for high-risk myomectomy.
authors.affiliation: Departamento de Radiologista Intervencionista, Hospital Israelita Albert Einstein – HIAE – São Paulo (SP), Brasil. felipenasser@einstein.br
authors.forename: Felipe
authors.initials: F
authors.lastname: Nasser
authors.forename: Breno Boueri
authors.initials: BB
authors.lastname: Affonso
authors.forename: Seleno Glauber
authors.initials: SG
authors.lastname: de Jesus-Silva
authors.forename: Dionésio de Oliveira
authors.initials: Dde O
authors.lastname: Coelho
authors.forename: Eduardo
authors.initials: E
authors.lastname: Zlotnik
authors.forename: Marcos de Lorenzo
authors.initials: Mde L
authors.lastname: Messina
authors.forename: Edmund Chada
authors.initials: EC
authors.lastname: Baracat
mesh_terms: D000328:Adult; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy*