title: Facile stereoslective synthesis of spiro[indole-oxiranes] by combination of phase transfer catalyst and ultrasound irradiation and their bioassay.
abstract: An alternative and environmentally benign pathway for diastereoslective synthesis of fluorinated spiro[indole-3,2'-oxirane]-3'-benzoyl-2(1H)-ones (2a-g) is reported. The spiro[indole-3,2'-oxiranes] derivatives were obtained in 90-97% yield exclusively via the epoxidation of 3-aroylmethylene indole-2-ones with 30% aqueous hydrogen peroxide using cetyltrimethyl ammonium bromide as a phase transfer catalyst under ultrasound irradiation. The lead compounds have been tested for their antimicrobial activity and antioxidant properties.
authors.affiliation: Department of Chemistry, University of Rajasthan, Jaipur, India. dranshudandia@yahoo.co.in
authors.forename: Anshu
authors.initials: A
authors.lastname: Dandia
authors.forename: Ruby
authors.initials: R
authors.lastname: Singh
authors.forename: Sumit
authors.initials: S
authors.lastname: Bhaskaran
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D001681:Biological Assay; D002384:Catalysis / Q000528:radiation effects; D044367:Phase Transition / Q000528:radiation effects; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D013141:Spiro Compounds