title: Successful treatment of Old World cutaneous leishmaniasis caused by Leishmania infantum with posaconazole.
abstract: Old World cutaneous leishmaniasis is a widespread and potentially disfiguring protozoal infection that is endemic in the Mediterranean basin, Africa, and parts of Asia. Human infection is caused by several species of Leishmania parasites, such as Leishmania infantum. Available systemic and topical treatments vary in efficacy and are often unjustified due to their toxicity. We report on a case that was treated with posaconazole, a drug typically considered an antifungal agent but which also targets specific metabolic pathways of the parasite.
authors.affiliation: Department of Pathology and Laboratory Medicine, St. Luke's-Roosevelt Hospital Center (University Hospital of Columbia University College of Physicians and Surgeons), St. Luke's Division, Clark 4th floor, 1111 Amsterdam Avenue, New York, NY 10025, USA. ap2647@columbia.edu
authors.forename: A E
authors.initials: AE
authors.lastname: Paniz Mondolfi
authors.forename: C
authors.initials: C
authors.lastname: Stavropoulos
authors.forename: T
authors.initials: T
authors.lastname: Gelanew
authors.forename: E
authors.initials: E
authors.lastname: Loucas
authors.forename: A M
authors.initials: AM
authors.lastname: Perez Alvarez
authors.forename: G
authors.initials: G
authors.lastname: Benaim
authors.forename: B
authors.initials: B
authors.lastname: Polsky
authors.forename: G
authors.initials: G
authors.lastname: Schoenian
authors.forename: E M
authors.initials: EM
authors.lastname: Sordillo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000235:genetics / Q000469:parasitology*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D014230:Triazoles / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000627:therapeutic use*
chemical_list: D014230:Triazoles; D014344:Trypanocidal Agents; C101425:posaconazole