title: Patient and parent psychosocial factors associated with health-related quality of life in pediatric inflammatory bowel disease.
abstract: OBJECTIVE
  The aim of the study was to examine the mediating role of youth depressive symptoms in the relation between parent distress and youth health-related quality of life (HRQOL) in a sample of adolescents with inflammatory bowel disease (IBD).
  
  
  METHODS
  Sixty-two adolescents, ages 13 to 17 years, with a confirmed diagnosis of IBD completed assessments of depressive symptoms and HRQOL. Each adolescent's primary caregiver completed a measure of parent stress related to his or her child's illness. Pediatric gastroenterologists provided data for disease severity assessments.
  
  
  RESULTS
  Multiple regression analyses revealed that adolescent depressive symptoms fully mediated the relation between parent distress and several dimensions of HRQOL (ie, general well-being, emotional functioning, social functioning, and total HRQOL). Moreover, mediation was observed after statistically controlling for the effect of disease severity, IBD diagnosis, and significant demographic parameters on HRQOL.
  
  
  CONCLUSIONS
  Findings suggest that adolescent depressive symptoms may serve as the mechanism through which parent distress is linked to poorer HRQOL in adolescents with IBD. Close monitoring of parent illness-related distress and adolescent depressive symptoms, as well as clinical interventions targeting these factors, is needed to promote optimal outcomes in adolescents with IBD.
authors.affiliation: Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Herzer
authors.forename: Lee A
authors.initials: LA
authors.lastname: Denson
authors.forename: Robert N
authors.initials: RN
authors.lastname: Baldassano
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Hommel
mesh_terms: D000293:Adolescent; D003863:Depression; D004644:Emotions; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000523:psychology*; D007398:Interpersonal Relations; D008297:Male; D008603:Mental Health; D010290:Parents / Q000523:psychology*; D011788:Quality of Life; D012044:Regression Analysis; D013315:Stress, Psychological