title: Assessment of cardiac diastolic dysfunction in HIV-infected people without cardiovascular symptoms in China.
abstract: This study assessed cardiac diastolic dysfunction (DD) in HIV-infected subjects without cardiovascular symptoms in China. Eighty-four HIV-infected patients without cardiovascular symptoms were recruited and compared with 30 HIV-negative control subjects. Cardiac DD was evaluated using echocardiography including tissue Doppler imaging. DD was detected in 47.6% of AIDS patients and 42.8% of HIV-positive patients, which was significantly higher than in HIV-negative controls. After logistic regression analysis, HIV infection was independently correlated with cardiac DD (P < 0.05). Among HIV-positive subjects, logistic regression analysis showed that zidovudine exposure was associated with higher prevalence of DD (P < 0.05). Asymptomatic cardiac DD was observed frequently in HIV-infected subjects. HIV infection itself and zidovudine exposure were correlated with a higher prevalence of cardiac DD.
authors.affiliation: Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: Y
authors.initials: Y
authors.lastname: Ye
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Zuo
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Han
authors.forename: Z
authors.initials: Z
authors.lastname: Qiu
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Zeng
authors.forename: T-S
authors.initials: TS
authors.lastname: Li
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D002681:China; D004452:Echocardiography; D005260:Female; D015658:HIV Infections / Q000150:complications*; D054144:Heart Failure, Diastolic / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence