title: Progress in the development of vision prostheses.
abstract: Degenerative retinal diseases like retinitis pigmentosa and age-related macular degeneration are among the most common causes of blindness worldwide. Electronic visual prostheses represent a potential therapeutic option of increasing importance in otherwise incurably impaired patients. Based on extensive animal experiments, several devices are now being tested in clinical trials. According to the placement of the electrodes, possible stimulation sites are located subretinally, epiretinally, along the optic nerve or cortically. Anatomical, physiological and pathophysiological aspects must be considered in development and clinical application. To provide an appropriate retinal substitute, the optimal integration and adaptation of the prosthesis into the highly complex system of the visual pathway is important. This article aims to summarize the relevant studies and provides an overview of the current status of developments and challenges that still need to be mastered.
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Matthaei
authors.forename: Oliver
authors.initials: O
authors.lastname: Zeitz
authors.forename: Matthias
authors.initials: M
authors.lastname: Keserü
authors.forename: Lars
authors.initials: L
authors.lastname: Wagenfeld
authors.forename: Ralf
authors.initials: R
authors.lastname: Hornig
authors.forename: Nils
authors.initials: N
authors.lastname: Post
authors.forename: Gisbert
authors.initials: G
authors.lastname: Richard
mesh_terms: D001766:Blindness / Q000209:etiology / Q000534:rehabilitation*; D006801:Humans; D011474:Prosthesis Design; D012164:Retinal Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D014792:Visual Acuity; D014795:Visual Pathways / Q000502:physiology*; D057488:Visual Prosthesis / Q000639:trends*