title: The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution.
abstract: Most ionizing radiation-induced damage is caused by radical oxygen species (ROS). Some radioprotectors, such as amifostine, exert radioprotective effects by scavenging radical oxygen species. Recent studies show that hydrogen (H) has antioxidant activities that protect the brain and intestine against ischaemia-reperfusion injury and stroke by selectively reducing hydroxyl and peroxynitrite radicals. However it is seldom regarded as a radioprotective agent. In like manner we hypothesize that hydrogen may be an effective, specific and novel radioprotective agent. But H2 is explosive, while hydrogen-rich solution (solution such as physiological saline saturated with molecular hydrogen) is safer.
authors.affiliation: Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Xiangyin Road, 200433, Shanghai, PR China.
authors.forename: Liren
authors.initials: L
authors.lastname: Qian
authors.forename: Bailong
authors.initials: B
authors.lastname: Li
authors.forename: Jianming
authors.initials: J
authors.lastname: Cai
authors.forename: Fu
authors.initials: F
authors.lastname: Gao
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D006859:Hydrogen / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D011837:Radiation-Protective Agents; D006859:Hydrogen