title: Surface analysis for compositional, chemical and structural imaging in pharmaceutics with mass spectrometry: a ToF-SIMS perspective.
abstract: We review the application of time-of-flight secondary-ion mass spectrometry (ToF-SIMS) for the surface chemical identification and distribution analysis (mapping) of pharmaceutically relevant materials. Specifically we explore the characterization of both solid state pharmaceuticals and bio-pharmaceuticals by ToF-SIMS; highlighting specific case studies concerning the distribution and stability of pharmaceutical actives within solid matrices, the face-specific properties of pharmaceutical crystals and elucidation of the structure/conformation of adsorbed proteins. Finally, potential future applications of ToF-SIMS in pharmaceutics are detailed.
authors.affiliation: Sansom Institute, University of South Australia, City East, SA 5000, Australia.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Barnes
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Kempson
authors.forename: Clive A
authors.initials: CA
authors.lastname: Prestidge
mesh_terms: D000818:Animals; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D018629:Spectrometry, Mass, Secondary Ion / Q000379:methods*; D013499:Surface Properties
chemical_list: D004364:Pharmaceutical Preparations