title: Pregnancy and pulmonary hypertension.
abstract: When pulmonary hypertension (PH) occurs in pregnancy, physiologic stress can overwhelm an already strained right ventricle resulting in right ventricular failure and death. Mortality remains unacceptably high (25%-30%). Patients with PH should be counseled to avoid pregnancy. This article discusses the physiologic changes of pregnancy that make it difficult for patients with PH, the pitfalls of transthoracic echocardiography in diagnosing PH in pregnancy, and the historical data regarding mortality. The causes of development of PH during pregnancy are discussed, and the limited data on management of patients with PH who choose to carry their pregnancy to term are reviewed.
authors.affiliation: Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208057, New Haven, CT 06520-8057, USA.
authors.forename: C Randall
authors.initials: CR
authors.lastname: Lane
authors.affiliation: Yale Pulmonary Hypertension Center, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 28057, LLCI 105D, New Haven, CT 06520-8057, USA. Electronic address: terence.trow@yale.edu.
authors.forename: Terence K
authors.initials: TK
authors.lastname: Trow
mesh_terms: D036861:Delivery, Obstetric; D037001:Directive Counseling; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D008428:Maternal Mortality; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D011256:Pregnancy Outcome