title: Retrospective comparison of magnetic resonance imaging features and histopathology in Crohn's disease patients.
abstract: OBJECTIVE
  To retrospectively compare histopathological findings of surgically resected bowel segments with magnetic resonance imaging (MRI) findings on Crohn's disease activity.
  
  
  METHODS
  Patients who underwent a MR enterography or enteroclysis before surgery were included after informed consent. MRI features (T1-enhancement, T1 and T2 stratification, T2 signal intensity, bowel wall thickness, presence of ulcerations, comb sign, creeping fat, and disease activity) were assessed by three experienced abdominal radiologists. An acute inflammatory score based on histopathology (parameters: mucosal ulceration, edema, depth and degree of neutrophils) was calculated. Interobserver variability for subjective MRI features was also assessed.
  
  
  RESULTS
  Thirty-nine segments in 25 patients (mean age 38 years) were included. Of the MRI features, disease activity per segment and bowel wall thickness had a positive association with the acute inflammatory score (p<0.05). T1-enhancement had a positive correlation with disease chronicity. All other MRI features did not have an association with the acute inflammatory score. Interobserver agreement between the three observers was weak to moderate.
  
  
  CONCLUSIONS
  MR features bowel wall thickness and disease activity per-segment reflect disease activity in Crohn's disease patients.
authors.affiliation: Academic Medical Center, Department of Radiology, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. m.l.ziech@amc.uva.nl
authors.forename: Manon L W
authors.initials: ML
authors.lastname: Ziech
authors.forename: Shandra
authors.initials: S
authors.lastname: Bipat
authors.forename: Joris J T H
authors.initials: JJ
authors.lastname: Roelofs
authors.forename: C Yung
authors.initials: CY
authors.lastname: Nio
authors.forename: Banafsche
authors.initials: B
authors.lastname: Mearadji
authors.forename: Sascha
authors.initials: S
authors.lastname: van Doorn
authors.forename: Anje M
authors.initials: AM
authors.lastname: Spijkerboer
authors.forename: Jaap
authors.initials: J
authors.lastname: Stoker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003424:Crohn Disease / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult