title: Targeting human dendritic cell subsets for improved vaccines.
abstract: Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.
authors.affiliation: Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA. hidekiu@baylorhealth.edu
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
authors.forename: Eynav
authors.initials: E
authors.lastname: Klechevsky
authors.forename: Nathalie
authors.initials: N
authors.lastname: Schmitt
authors.forename: Ling
authors.initials: L
authors.lastname: Ni
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Flamar
authors.forename: Sandra
authors.initials: S
authors.lastname: Zurawski
authors.forename: Gerard
authors.initials: G
authors.lastname: Zurawski
authors.forename: Karolina
authors.initials: K
authors.lastname: Palucka
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.forename: Sangkon
authors.initials: S
authors.lastname: Oh
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology*; D006801:Humans; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines