title: Nanoengineered surfaces enhance drug loading and adhesion.
abstract: To circumvent the barriers encountered by macromolecules at the gastrointestinal mucosa, sufficient therapeutic macromolecules must be delivered in close proximity to cells.(1) Previously, we have shown that silicon nanowires penetrate the mucous layer and adhere directly to cells under high shear.(2) In this work, we characterize potential reservoirs and load macromolecules into interstitial space between nanowires. We show significant increases in loading capacity due to nanowires while retaining adhesion of loaded particles under high shear.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, United States.
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Fischer
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Jayagopal
authors.forename: Ganesh
authors.initials: G
authors.lastname: Nagaraj
authors.forename: R Hugh
authors.initials: RH
authors.lastname: Daniels
authors.forename: Esther M
authors.initials: EM
authors.lastname: Li
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Silvestrini
authors.forename: Tejal A
authors.initials: TA
authors.lastname: Desai
mesh_terms: D002448:Cell Adhesion; D007413:Intestinal Mucosa / Q000378:metabolism; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D004364:Pharmaceutical Preparations