title: Regulation of mammalian target of rapamycin and mitogen activated protein kinase pathways by BCR-ABL.
abstract: A large body of evidence has established that BCR-ABL regulates engagement and activation of mammalian target of rapamycin (mTOR) and mitogen activated protein kinase (MAPK) signaling cascades. mTOR-mediated signals, as well as signals transduced by ERK, JNK, and p38 MAPK, are important components of the aberrant signaling induced by BCR-ABL. Such deregulation of mTOR or MAPK pathways contributes to BCR-ABL leukemogenesis, and their targeting with selective inhibitors provides an approach to enhance antileukemic responses and/or overcome leukemic cell resistance in chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). This review explores recent advances in our understanding of mTOR and MAPK signaling in BCR-ABL-expressing leukemias and discusses the potential therapeutic targeting of these pathways in CML and Ph+ ALL.
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center and Division of Hematology/Oncology, Northwestern University Medical School and Jesse Brown VA Medical Center, Chicago, IL, USA.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Redig
authors.forename: Eliza
authors.initials: E
authors.lastname: Vakana
authors.forename: Leonidas C
authors.initials: LC
authors.lastname: Platanias
mesh_terms: D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D016044:Fusion Proteins, bcr-abl; D058570:TOR Serine-Threonine Kinases; D020928:Mitogen-Activated Protein Kinases