title: Smoking reduces survival in young females with lung adenocarcinoma after curative resection.
abstract: The aim of this study was to investigate effects of smoking on the overall survival of young female lung adenocarcinoma patients after curative resection. A total of 282 surgically treated young females (younger than 40) with histologically confirmed primary lung adenocarcinoma were studied retrospectively. Overall survivals (OS) and related prognostic factors were analyzed. The 5-year OS of current-smokers and non-smokers were 20 and 36.6%, respectively (P = 0.03). As for patients with stage I disease, the 5-year OS of current-smokers and non-smokers were 50 and 68.8%, respectively, (P = 0.02). Smoking (RR = 3.15, CI 1.726-8.786) was identified as an independent prognostic factor. Current-smokers (21.4 vs. 14.5%, P = 0.03) and non-smokers (37.9 vs. 28.8%, P = 0.02) all benefited from adjuvant chemotherapy. Among young female patients with adenocarcinoma, current-smokers have a lower survival rate than non-smokers, especially patients with stage I disease.
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Rd, 200433 Shanghai, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Gening
authors.initials: G
authors.lastname: Jiang
authors.forename: Jiaan
authors.initials: J
authors.lastname: Ding
authors.forename: Jiang
authors.initials: J
authors.lastname: Fan
authors.forename: Wenxin
authors.initials: W
authors.lastname: He
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Song
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced / Q000401:mortality* / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D002289:Carcinoma, Non-Small-Cell Lung / Q000139:chemically induced / Q000401:mortality* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000401:mortality* / Q000601:surgery*; D009367:Neoplasm Staging; D011379:Prognosis; D012907:Smoking / Q000009:adverse effects*; D015996:Survival Rate; D055815:Young Adult