title: Loss of residual renal function was not associated with glycemic control in patients on peritoneal dialysis.
abstract: BACKGROUND
  Better glycemic control has been reported to slow the progression of nephropathy in predialysis diabetic patients. However, the relationship between glycemic control and residual renal function (RRF) in patients on peritoneal dialysis (PD) is uncertain.
  
  
  METHODS
  89 incident diabetic patients on PD were recruited from 5 centers. We measured glomerular filtration rate (GFR) and hemoglobin A1c (HbA1c) within 2 months (baseline) after the start of PD and at 6 and 12 months. GFR was calculated as the average of renal creatinine and urea clearances. We analyzed whether mean HbA1c was associated with change in GFR (ΔGFR) over 1 year.
  
  
  RESULTS
  During the first year of PD, ΔGFR was -1.7 ± 3.4 mL/min/1.73 m² and was not affected by mean HbA1c. Acute hemodialysis before starting PD and mean arterial diastolic pressure were related to the decline of GFR in a multivariate analysis.
  
  
  CONCLUSIONS
  Glycemic control was not associated with change in RRF in diabetic patients during the first year after starting PD.
authors.affiliation: Department of Internal Medicine,1 Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.
authors.forename: Su-Ah
authors.initials: SA
authors.lastname: Sung
authors.forename: Young-Hwan
authors.initials: YH
authors.lastname: Hwang
authors.forename: Sejoong
authors.initials: S
authors.lastname: Kim
authors.forename: Sung Gyun
authors.initials: SG
authors.lastname: Kim
authors.forename: Jieun
authors.initials: J
authors.lastname: Oh
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.forename: So-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Curie
authors.initials: C
authors.lastname: Ahn
authors.forename: Kook-Hwan
authors.initials: KH
authors.lastname: Oh
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003404:Creatinine / Q000652:urine; D003920:Diabetes Mellitus / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin