title: Intracoronary delivery of mesenchymal stem cells reduces proarrhythmogenic risks in swine with myocardial infarction.
abstract: BACKGROUND
  The electrophysiological consequences of mesenchymal stem cell (MSC) therapy in ischemic heart disease have not been fully understood.
  
  
  METHODS
  Swine myocardial infarction (MI) model by intracoronary balloon occlusion received MSC solution or 0.9% NaCl. Six weeks later, heart rate turbulence (HRT), dispersion of action potential durations (APD) and repolarization time (RT) (APDd and RTd), slope of APD reconstitution curve and programmed electrical stimulation were used to evaluate the ventricular arrhythmic risks.
  
  
  RESULTS
  MSC treatment could significantly ameliorate the abnormal HRT, APD(90), APDd, RT and RTd. The slope of APD reconstitution curve in MSC group was higher than control group but lower than MI group. MSC therapy markedly reduced inducible malignant ventricular arrhythmias (VAs), and improved impaired cardiac performances and cardiac fibrosis.
  
  
  CONCLUSIONS
  This study provides strong evidence that MSC infusion via intracoronary route does not cause VAs but tends to reduce the risk of malignant VAs.
authors.affiliation: Department of Cardiology, Yijishan Hospital of Wannan Medical College, Wuhu, People's Republic of China.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: C
authors.initials: C
authors.lastname: Ding
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: Q
authors.initials: Q
authors.lastname: Shan
authors.forename: J
authors.initials: J
authors.lastname: Zou
authors.forename: K
authors.initials: K
authors.lastname: Cao
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006439:Hemodynamics; D007267:Injections; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D013552:Swine; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000517:prevention & control; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000517:prevention & control