title: Use of aliphatic poly(amide urethane)s for the controlled release of 5-fluorouracil.
abstract: The controlled release of 5-fluorouracil (5FU) from aliphatic poly(amide urethane)s (PURs) was studied in vitro. Linear PUR conjugates were prepared by the reaction between oligo(ɛ-caprolactone) (PCL), oligolactide (PLA), copolymers of ɛ-caprolactone (CL) and rac-lactide (rac-LA), dihydroxy(polyethylene adipate) (OEDA) with 1,6-diisocyanatohexane (HDI). Release of 5FU from PURs was found to depend on the nature of oligoester units and consist of soft and hard segments.
authors.affiliation: Faculty of Pharmacy, Department of Inorganic and Analytical Chemistry, Medical University of Warsaw, ul Banacha 1, 02-097 Warsaw, Poland. marcin.sobczak@wum.edu.pl
authors.forename: Marcin
authors.initials: M
authors.lastname: Sobczak
authors.forename: Magdalena
authors.initials: M
authors.lastname: Hajdaniak
authors.forename: Piotr
authors.initials: P
authors.lastname: Goś
authors.forename: Ewa
authors.initials: E
authors.lastname: Olędzka
authors.forename: Wacław L
authors.initials: WL
authors.lastname: Kołodziejski
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D011140:Polyurethanes; D005472:Fluorouracil