title: Low agreement between the T-SPOT®.TB assay and the tuberculin skin test among college students in China.
abstract: T-SPOT®.TB and the tuberculin skin test (TST) were used to screen for latent tuberculosis infection among 899 Chinese college students. The positivity rates for T-SPOT®.TB and TST were respectively 13.0% (95% confidence interval [CI] 10.4-15.9) and 24.9% (95%CI 21.5-28.6) among students with a bacille Calmette-Guérin (BCG) scar (agreement of both tests 72.3%; 95%CI 68.6-75.8; κ = 0.118), and respectively 17.3% (95%CI 11.7-24.2) and 23.7% (95%CI 17.3-31.2) among those without a BCG scar (agreement 73.1%; 95%CI 65.4-79.9; κ = 0.179). These results demonstrate low agreement between the TST and T-SPOT.TB in the Chinese population studied.
authors.affiliation: Department of Laboratory Medicine, Jinan Sixth Hospital, Zhangqiu, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Jiang
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Meng
authors.forename: G
authors.initials: G
authors.lastname: Song
authors.forename: N
authors.initials: N
authors.lastname: Cheng
authors.forename: E A
authors.initials: EA
authors.lastname: Graviss
authors.forename: X
authors.initials: X
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D001500:BCG Vaccine; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D008297:Male; D008403:Mass Screening / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011237:Predictive Value of Tests; D015995:Prevalence; D013334:Students; D014374:Tuberculin Test; D014495:Universities; D055815:Young Adult
chemical_list: D001500:BCG Vaccine; D007371:Interferon-gamma