title: A robotic approach to 4D real-time tumor tracking for radiotherapy.
abstract: Respiratory and cardiac motions induce displacement and deformation of the tumor volumes in various internal organs. To accommodate this undesired movement and other errors, physicians incorporate a large margin around the tumor to delineate the planning target volume, so that the clinical target volume receives the prescribed radiation dose under any scenario. Consequently, a large volume of healthy tissue is irradiated and sometimes it is difficult to spare critical organs adjacent to the tumor. In this study we have proposed a novel approach to the 4D active tracking and dynamic delivery incorporating the tumor motion prediction technique. This method has been applied to the two commercially available robotic treatment couches. The proposed algorithm can predict the tumor position and the robotic systems are able to continuously track the tumor during radiation dose delivery. Therefore a precise dose is given to a moving target while the dose to the nearby critical organs is reduced to improve the patient treatment outcome. The efficacy of the proposed method has been investigated by extensive computer simulation. The tumor tracking method is simulated for two couches: HexaPOD robotic couch and ELEKTA Precise Table. The comparison results have been presented in this paper. In order to assess the clinical significance, dosimetric effects of the proposed method have been analyzed.
authors.affiliation: Department of Radiation Oncology, Medical Physics Division, Kimmel Cancer Center (NCI-designated), Thomas Jefferson University, Philadelphia, PA 19107, USA. ivan.buzurovic@jeffersonhospital.org
authors.forename: I
authors.initials: I
authors.lastname: Buzurovic
authors.forename: K
authors.initials: K
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: T K
authors.initials: TK
authors.lastname: Podder
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D009068:Movement; D011881:Radiotherapy, Computer-Assisted / Q000295:instrumentation*; D012371:Robotics / Q000295:instrumentation*; D013997:Time Factors