title: Significant retinal capillary basement membrane thickening in hyperglycemic and normoglycemic diabetic-prone (DP) BB Wistar rats.
abstract: The diabetic-prone BioBreeding Wistar (BB/DP) rat is an autoimmune model of insulin-dependent diabetes mellitus. Approximately 90% of the animals (BB/DPh) are hyperglycemic by 90-120 days of age, while the remaining ~10% (BB/DPn) and diabetes-resistant rats (BB/DR) are normoglycemic for life. The transmission electron microscope data from this study demonstrate expected significant age- and diabetes-related increases in retinal capillary basement membrane (RCBM) widths in (BB/DPh) rats relative to BB/DR animals. However, the data show, for the first time, an unexpected significant RCBM thickening in (BB/DPn) rats compared to BB/DR animals at 6 months and 1 year post-onset of hyperglycemia.
authors.affiliation: Department of Anatomy and Cell Biology, University of North Dakota School of Medicine & Health Sciences, Grand Forks, North Dakota 58202-9037, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Greenwood
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ressler
authors.forename: Janice L
authors.initials: JL
authors.lastname: Audette
authors.forename: Donna I
authors.initials: DI
authors.lastname: Laturnus
authors.forename: Rothanak
authors.initials: R
authors.lastname: Chhoun
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Teiken
authors.forename: Edward C
authors.initials: EC
authors.lastname: Carlson
mesh_terms: D000367:Age Factors; D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure*; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D002196:Capillaries / Q000648:ultrastructure*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000097:blood / Q000209:etiology / Q000473:pathology*; D004195:Disease Models, Animal; D008297:Male; D046529:Microscopy, Electron, Transmission; D051381:Rats; D011913:Rats, Inbred BB; D012171:Retinal Vessels / Q000648:ultrastructure*
chemical_list: D001786:Blood Glucose