title: Mesenteric venous thrombosis in a child with type 2 protein S deficiency.
abstract: A 5-year-old girl presented with abdominal pain and bloody stools 2 weeks after suffering from influenza A infection. Enhanced computed tomographic scan showed widespread splanchnic venous thrombosis and small intestine necrosis. She recovered after the necrotic bowel was resected. The patient continues to receive anticoagulant therapy. Thrombophilia screening after the complete resolution consistently showed mildly decreased protein S (PS) activity with normal PS antigen levels. Sequence analysis detected a heterozygous K196E mutation in the PROS1 gene. Type 2 PS deficiency was diagnosed. This is the first report of mesenteric vein thrombosis in a child with a type 2 PS deficiency.
authors.affiliation: Department of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Akira
authors.initials: A
authors.lastname: Morimoto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nozaki
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kashii
authors.forename: Toshinori
authors.initials: T
authors.lastname: Aihara
authors.forename: Kosaku
authors.initials: K
authors.lastname: Maeda
authors.forename: Mariko Y
authors.initials: MY
authors.lastname: Momoi
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001798:Blood Proteins / Q000235:genetics; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy; D007422:Intestines / Q000098:blood supply / Q000601:surgery; D007511:Ischemia / Q000235:genetics / Q000601:surgery; D008641:Mesenteric Vascular Occlusion / Q000235:genetics* / Q000601:surgery; D009154:Mutation; D053139:Oseltamivir / Q000627:therapeutic use; D017293:Protein S; D018455:Protein S Deficiency / Q000150:complications* / Q000235:genetics; D020246:Venous Thrombosis / Q000235:genetics* / Q000601:surgery
chemical_list: D000998:Antiviral Agents; D001798:Blood Proteins; C523390:PROS1 protein, human; D017293:Protein S; D053139:Oseltamivir