title: Synthesis, glucose uptake activity and structure-activity relationships of some novel glitazones incorporated with glycine, aromatic and alicyclic amine moieties via two carbon acyl linker.
abstract: Three series of novel glitazones were designed and prepared by using appropriate synthetic schemes to incorporate glycine, aromatic and alicyclic amines via two carbon linker. Compounds were synthesized both under conventional and microwave methods. Nineteen out of twenty four synthesized compounds were evaluated for their in vitro glucose uptake activity using isolated rat hemi-diaphragm. Compounds, 6, 9a, 13a, 13b, 13c, 13f and 13h exhibited significant glucose uptake activity. Illustration about their synthesis and in vitro glucose uptake activity is described along with the structure-activity relationships.
authors.affiliation: Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Rocklands, Ootacamund 643 001, India. prashantha@jsscpooty.org
authors.forename: B R Prashantha
authors.initials: BR
authors.lastname: Kumar
authors.forename: Mukesh
authors.initials: M
authors.lastname: Soni
authors.forename: S Santhosh
authors.initials: SS
authors.lastname: Kumar
authors.forename: Kuldeep
authors.initials: K
authors.lastname: Singh
authors.forename: Mohan
authors.initials: M
authors.lastname: Patil
authors.forename: R B Nasir
authors.initials: RB
authors.lastname: Baig
authors.forename: Laxmi
authors.initials: L
authors.lastname: Adhikary
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D003964:Diaphragm / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005998:Glycine / Q000138:chemical synthesis / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D008958:Models, Molecular; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000588:Amines; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D005947:Glucose; D005998:Glycine