title: Interaction between immunoglobulin allotypes and NK receptor genes in diabetes post-hepatitis C virus infection.
abstract: Genetic interactions between natural killer (NK) cells immunoglobulin-like receptor (KIR) genes and immunoglobulin allotypes have been previously reported in type 2 diabetes mellitus (DM) patients. Puerto Rican Americans with a history of intravenous drug use who developed DM following HCV infection (n=32) were compared to individuals infected with HCV without diabetes (n=121) and to DM non-infected individuals (n=95). Subjects were genotyped for KIRs and immunoglobulin allotypes. We found interactions of immunoglobulin allotypes KM3/KM3 with NK inhibitory receptors 2DL3/2DL3, 2DL1 in the absence of 2DS4 associated with susceptibility to DM in HCV infected individuals. These data suggest the possibility that a subset of patients with HCV could have an immune-mediated component contributing to the development of DM.
authors.affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
authors.forename: Julio
authors.initials: J
authors.lastname: Granados-Montiel
authors.forename: Joaquin
authors.initials: J
authors.lastname: Zúñiga
authors.forename: Jose
authors.initials: J
authors.lastname: Azocar
authors.forename: Edmond J
authors.initials: EJ
authors.lastname: Feris
authors.forename: Daniel
authors.initials: D
authors.lastname: Terreros
authors.forename: Charles E
authors.initials: CE
authors.lastname: Larsen
authors.forename: Olga P
authors.initials: OP
authors.lastname: Clavijo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cruz-Lagunas
authors.forename: Derek
authors.initials: D
authors.lastname: Middleton
authors.forename: Chester A
authors.initials: CA
authors.lastname: Alper
authors.forename: Janardan P
authors.initials: JP
authors.lastname: Pandey
authors.forename: Edmond J
authors.initials: EJ
authors.lastname: Yunis
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications / Q000276:immunology; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D054340:Receptors, KIR / Q000235:genetics* / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D015236:HLA-C Antigens; D007126:Immunoglobulin Allotypes; D054340:Receptors, KIR