title: The non-selective monovalent cationic channels TRPM4 and TRPM5.
abstract: Transient Receptor Potential (TRP) proteins are non-selective cationic channels with a consistent Ca(2+)-permeability, except for TRPM4 and TRPM5 that are not permeable to this ion. However, Ca(2+) is a major regulator of their activity since both channels are activated by a rise in internal Ca(2+). Thus TRPM4 and TRPM5 are responsible for most of the Ca(2+)-activated non-selective cationic currents (NSC(Ca)) recorded in a large variety of tissues. Their activation induces cell-membrane depolarization that modifies the driving force for ions as well as activity of voltage gated channels and thereby strongly impacts cell physiology. In the last few years, the ubiquitously expressed TRPM4 channel has been implicated in insulin secretion, the immune response, constriction of cerebral arteries, the activity of inspiratory neurons and cardiac dysfunction. Conversely, TRPM5 whose expression is more restricted, has until now been mainly implicated in taste transduction.
authors.affiliation: Groupe Cœur et Ischémie, EA 3212, Université de Caen, Sciences D, F-14032, Caen Cedex, France, romain.guinamard@unicaen.fr
authors.forename: Romain
authors.initials: R
authors.lastname: Guinamard
authors.forename: Laurent
authors.initials: L
authors.lastname: Sallé
authors.forename: Christophe
authors.initials: C
authors.lastname: Simard
mesh_terms: D000818:Animals; D001703:Biophysics; D020013:Calcium Signaling; D006801:Humans; D017136:Ion Transport; D011487:Protein Conformation; D050053:TRPM Cation Channels / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*
chemical_list: D050053:TRPM Cation Channels; C437888:TRPM4 protein, human; C404409:TRPM5 protein, human