title: Prevalence and histopathology of chronic polypoid sinusitis in pediatric patients with cystic fibrosis.
abstract: BACKGROUND
  Chronic sinusitis is almost invariably a feature of cystic fibrosis. However, data on the endoscopically confirmed prevalence of chronic polypoid sinusitis (CPS) and its histological features are limited.
  
  
  METHODS
  Single centre prospective observational study. Unselected pediatric CF patients (n=81; ≤ 18 years) were endoscopically assessed for the prevalence of CPS. Sixteen of these underwent sinus surgery. The surgically obtained sinus specimens were compared to sinus specimen of non-CF-patients undergoing sinus surgery (n=61), using conventional histology and immunohistochemistry.
  
  
  RESULTS
  The prevalence of endoscopically confirmed CPS increased with age from 19% in infants younger than six years reaching 45% in adolescents. In CF patients, histology typically showed dilated glandular ducts and a predominance of mucous glands. The number of plasma cells and mast cells but not of eosinophils was significantly elevated compared to non-CF patients.
  
  
  CONCLUSIONS
  Prevalence of CPS in pediatric CF patients increases with age. Our findings indicate that chronic bacterial infection rather than allergic mechanisms may forward this pathology.
authors.affiliation: University of Tuebingen, Department of Otolaryngology, Elfriede-Aulhorn-Straße, Germany. Sebastian.Schraven@med.uni-tuebingen.de
authors.forename: Sebastian P
authors.initials: SP
authors.lastname: Schraven
authors.forename: Manfred
authors.initials: M
authors.lastname: Wehrmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wagner
authors.forename: Gunnar
authors.initials: G
authors.lastname: Blumenstock
authors.forename: Assen
authors.initials: A
authors.lastname: Koitschev
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001424:Bacterial Infections; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications* / Q000503:physiopathology; D004724:Endoscopy; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology; D010254:Paranasal Sinus Diseases / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D011127:Polyps / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D015995:Prevalence; D011446:Prospective Studies; D012852:Sinusitis / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D014666:Vasomotor System / Q000503:physiopathology