title: Anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from root of Piper sarmentosum Roxb.
abstract: BACKGROUND
  Piper sarmentosum Roxb. (Cha Phul) is a plant in the Piperaceae family which the whole plant is used as an expectorant and the leaf as a carminative. Many extracts from the plants in this family show anti-nociceptive, anti-inflammatory and antipyretic activities in various animal models.
  
  
  OBJECTIVE
  To investigate the anti-inflammatory, anti-nociceptive and antipyretic effects of the ethanol extract from P. sarmentosum root.
  
  
  METHODS
  In vivo study.
  
  
  RESULTS
  P. sarmentosum extract significantly inhibited ethyl phenylpropiolate-induced ear edema as well as carrageenan-induced hind paw edema in rats. The extract reduced transudative and granuloma weights of the chronic inflammatory model using the cotton pellet-induced granuloma formation in rats. The extract exerted a pronounced inhibitory activity on the early phase and late phase of the formalin test in mice. In addition, the extract elicited an antipyretic activity on yeast-induced hyperthermia in rats.
  
  
  CONCLUSIONS
  P. sarmentosum extract possessed anti-inflammatory, anti-nociceptive and antipyretic activities.
authors.affiliation: Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani, Thailand. seewaboon@gmail.com
authors.forename: Seeewaboon
authors.initials: S
authors.lastname: Sireeratawong
authors.forename: Supaporn
authors.initials: S
authors.lastname: Vannasiri
authors.forename: Suphachai
authors.initials: S
authors.lastname: Sritiwong
authors.forename: Arunporn
authors.initials: A
authors.lastname: Itharat
authors.forename: Kanjana
authors.initials: K
authors.lastname: Jaijoy
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D000431:Ethanol; D008297:Male; D051379:Mice; D010147:Pain Measurement; D031701:Piper / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D010936:Plant Extracts; D000431:Ethanol