title: Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: a cardiovascular magnetic resonance study.
abstract: BACKGROUND
  Arterial stiffness is considered as an independent predictor of cardiovascular mortality, and is increasingly used in clinical practice. This study aimed at evaluating the consistency of the automated estimation of regional and local aortic stiffness indices from cardiovascular magnetic resonance (CMR) data.
  
  
  RESULTS
  Forty-six healthy subjects underwent carotid-femoral pulse wave velocity measurements (CF_PWV) by applanation tonometry and CMR with steady-state free-precession and phase contrast acquisitions at the level of the aortic arch. These data were used for the automated evaluation of the aortic arch pulse wave velocity (Arch_PWV), and the ascending aorta distensibility (AA_Distc, AA_Distb), which were estimated from ascending aorta strain (AA_Strain) combined with either carotid or brachial pulse pressure. The local ascending aorta pulse wave velocity AA_PWVc and AA_PWVb were estimated respectively from these carotid and brachial derived distensibility indices according to the Bramwell-Hill theoretical model, and were compared with the Arch_PWV. In addition, a reproducibility analysis of AA_PWV measurement and its comparison with the standard CF_PWV was performed. Characterization according to the Bramwell-Hill equation resulted in good correlations between Arch_PWV and both local distensibility indices AA_Distc (r = 0.71, p < 0.001) and AA_Distb (r = 0.60, p < 0.001); and between Arch_PWV and both theoretical local indices AA_PWVc (r = 0.78, p < 0.001) and AA_PWVb (r = 0.78, p < 0.001). Furthermore, the Arch_PWV was well related to CF_PWV (r = 0.69, p < 0.001) and its estimation was highly reproducible (inter-operator variability: 7.1%).
  
  
  CONCLUSIONS
  The present work confirmed the consistency and robustness of the regional index Arch_PWV and the local indices AA_Distc and AA_Distb according to the theoretical model, as well as to the well established measurement of CF_PWV, demonstrating the relevance of the regional and local CMR indices.
authors.affiliation: Inserm U678, Paris, France. anas.dogui@imed.jussieu.fr
authors.forename: Anas
authors.initials: A
authors.lastname: Dogui
authors.forename: Nadjia
authors.initials: N
authors.lastname: Kachenoura
authors.forename: Frédérique
authors.initials: F
authors.lastname: Frouin
authors.forename: Muriel
authors.initials: M
authors.lastname: Lefort
authors.forename: Alain
authors.initials: A
authors.lastname: De Cesare
authors.forename: Elie
authors.initials: E
authors.lastname: Mousseaux
authors.forename: Alain
authors.initials: A
authors.lastname: Herment
mesh_terms: D000328:Adult; D001011:Aorta / Q000033:anatomy & histology / Q000502:physiology*; D057205:Automation, Laboratory; D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000502:physiology; D004548:Elasticity; D005263:Femoral Artery / Q000502:physiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008365:Manometry; D008875:Middle Aged; D008955:Models, Cardiovascular; D015588:Observer Variation; D011237:Predictive Value of Tests; D011673:Pulsatile Flow; D015203:Reproducibility of Results; D055815:Young Adult