title: Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression.
abstract: Alternative RNA processing mechanisms, including alternative splicing and alternative polyadenylation, are increasingly recognized as important regulators of gene expression. This article will focus on what has recently been described about alternative polyadenylation in development, differentiation, and disease in higher eukaryotes. We will also describe how the evolving global methodologies for examining the cellular transcriptome, both experimental and bioinformatic, are revealing new details about the complex nature of alternative 3' end formation, as well as interactions with other RNA-mediated and RNA processing mechanisms.
authors.affiliation: Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, MSB E671, 185 South Orange Ave., Newark, NJ 07103, USA. lutzcs@umdnj.edu
authors.forename: Carol S
authors.initials: CS
authors.lastname: Lutz
authors.forename: Alexandra
authors.initials: A
authors.lastname: Moreira
mesh_terms: D017398:Alternative Splicing / Q000235:genetics / Q000502:physiology*; D000818:Animals; D004526:Efficiency; D056890:Eukaryota / Q000235:genetics* / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D026723:Polyadenylation / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger