title: Inductive heating with magnetic materials inside flow reactors.
abstract: Superparamagnetic nanoparticles coated with silica gel or alternatively steel beads are new fixed-bed materials for flow reactors that efficiently heat reaction mixtures in an inductive field under flow conditions. The scope and limitations of these novel heating materials are investigated in comparison with conventional and microwave heating. The results suggest that inductive heating can be compared to microwave heating with respect to rate acceleration. It is also demonstrated that a very large diversity of different reactions can be performed under flow conditions by using inductively heated flow reactors. These include transfer hydrogenations, heterocyclic condensations, pericyclic reactions, organometallic reactions, multicomponent reactions, reductive cyclizations, homogeneous and heterogeneous transition-metal catalysis. Silica-coated iron oxide nanoparticles are stable under many chemical conditions and the silica shell could be utilized for further functionalization with Pd nanoparticles, rendering catalytically active heatable iron oxide particles.
authors.affiliation: Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Ceylan
authors.forename: Ludovic
authors.initials: L
authors.lastname: Coutable
authors.forename: Jens
authors.initials: J
authors.lastname: Wegner
authors.forename: Andreas
authors.initials: A
authors.lastname: Kirschning
mesh_terms: D002384:Catalysis; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry*; D006361:Heating; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008872:Microwaves; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D006571:Heterocyclic Compounds; C000499:ferric oxide; D012822:Silicon Dioxide