title: Frequency and clinical course of invasive pneumococcal disease caused by penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae in Thai children.
abstract: OBJECTIVE
  This study assessed clinical differences between invasive pneumococcal disease (IPD) caused by penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae.
  
  
  METHODS
  Patients with IPD confirmed during January 1996-December 2007 at three hospitals were included. Clinical characteristics and outcomes were compared between patients infected with penicillin-resistant Streptococcus pneumoniae (PRSP) and penicillin-sensitive Streptococcus pneumoniae (PSSP).
  
  
  RESULTS
  Sixty-nine patients with IPD were identified during the study period, 20 (29%) of whom were infected with PRSP and 49 (71%) with PSSP. Sex, mean age, underlying diseases and seasonal variation did not differ statistically between the two groups. No significant differences were identified in clinical course as measured by time until defervescence, duration of hospitalization and clinical outcome. Minimum inhibitory concentrations (MIC) for other antibiotics were determined; 20% and 10% of PRSP isolates were nonsusceptible to cephalosporins and meropenem, respectively, but all isolates were sensitive to vancomycin.
  
  
  CONCLUSIONS
  There were no significant differences identified in the clinical epidemiology of lPD cases caused by PRSP and PSSP.
authors.affiliation: Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand. natawan_sir@yahoo.com
authors.forename: Natawan
authors.initials: N
authors.lastname: Siripongpreeda
authors.forename: Weerawan
authors.initials: W
authors.lastname: Hattasingh
authors.forename: Patcharin
authors.initials: P
authors.lastname: Amornvipas
authors.forename: Boonchuay
authors.initials: B
authors.lastname: Eampokalap
authors.forename: Supachat
authors.initials: S
authors.lastname: Sakoolgnam
authors.forename: Chitsanu
authors.initials: C
authors.lastname: Pancharoen
authors.forename: Usa
authors.initials: U
authors.lastname: Thisyakorn
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use*; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D011379:Prognosis; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D013785:Thailand; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins