title: Effects of low doses of intracerebroventricular 6-OHDA on the levels of monoaminergic neurotransmitters in rat brain structures.
abstract: The objective of this study was to determine the degree and specificity of noradrenergic lesions in different areas of the rat brain after intracerebroventricular administration of low doses of 6-hydroxydopamine (6-OHDA) into both lateral ventricles. Our interest focused on the induction of an effective hypothalamic lesion. The results suggest that small doses of 6-OHDA (25 or 50 μg per ventricle) could effectively damage the noradrenergic system in the hypothalamus without significant interfering with the dopamine level and with only a modest reduction in the serotonin concentration.
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland. annasc@if-pan.krakow.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Sadakierska-Chudy
authors.forename: Anna
authors.initials: A
authors.lastname: Haduch
authors.forename: Krystyna
authors.initials: K
authors.lastname: Gołembiowska
authors.forename: Władysława A
authors.initials: WA
authors.lastname: Daniel
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000008:administration & dosage* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D016627:Oxidopamine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D016627:Oxidopamine; D004298:Dopamine; D009638:Norepinephrine