title: Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: correlation with tumor necrosis factor-α (TNF-α) and 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)).
abstract: OBJECTIVE
  The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)) in patients with fibromyalgia.
  
  
  METHODS
  Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-α, IL-6 and 8-iso-PGF(2α) levels were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Serum levels of ADMA and TNF-α and plasma levels 8-iso-PGF(2α) were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-α and 8-iso-PGF(2α) levels in patients with fibromyalgia.
  
  
  CONCLUSIONS
  This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF(2α) and TNF-α concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia.
authors.affiliation: Department of Pharmacology, Istanbul University, Faculty of Pharmacy, 34116, Beyazit, Istanbul, Turkey. gokce_topal@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Topal
authors.forename: A
authors.initials: A
authors.lastname: Donmez
authors.forename: B S Uydes
authors.initials: BS
authors.lastname: Doğan
authors.forename: M
authors.initials: M
authors.lastname: Kucur
authors.forename: D Taspinar
authors.initials: DT
authors.lastname: Cengiz
authors.forename: F B
authors.initials: FB
authors.lastname: Berkoz
authors.forename: N
authors.initials: N
authors.lastname: Erdogan
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D005356:Fibromyalgia / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D014409:Tumor Necrosis Factor-alpha; C075750:8-epi-prostaglandin F2alpha; C018524:N,N-dimethylarginine; D001120:Arginine; D015237:Dinoprost