title: Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.
abstract: This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and vascular diseases.
authors.affiliation: Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. hbsun2000@yahoo.com
authors.forename: Huaming
authors.initials: H
authors.lastname: Sheng
authors.forename: Hongbin
authors.initials: H
authors.lastname: Sun
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008659:Metabolic Diseases / Q000188:drug therapy*; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014652:Vascular Diseases / Q000188:drug therapy*
chemical_list: D001688:Biological Products; D053978:Pentacyclic Triterpenes