title: A novel oncoprotein Pirh2: rising from the shadow of MDM2.
abstract: Pirh2 (p53-induced RING-H2) is an E3 ubiquitin ligase that can target p53 for degradation and thereby repress a diverse group of biological activities regulated by p53. Notably, Pirh2, rather than MDM2, is the primary degrader of active p53 under conditions of DNA damage. Moreover, Pirh2 is highly expressed in multiple cancer cell lines regardless of p53 status. Recent research has shown that Pirh2 is involved in many signalling pathways related to the genesis and evolution of cancer. This review aims to summarize a comprehensive picture of the role of Pirh2 in cellular processes and its significance to tumorigenesis. Furthermore, this review focuses on its potential role as a cancer therapeutic target.
authors.affiliation: School of Medicine, Wuhan University, Wuhan, China.
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Lanlan
authors.initials: L
authors.lastname: Dong
authors.forename: Biwen
authors.initials: B
authors.lastname: Peng
authors.forename: Xiaohua
authors.initials: X
authors.lastname: He
authors.forename: Wanhong
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D015513:Oncogene Proteins / Q000378:metabolism*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D015513:Oncogene Proteins; D051736:Proto-Oncogene Proteins c-mdm2; C485369:RCHY1 protein, human; D044767:Ubiquitin-Protein Ligases