title: Probing and syringing with 3% solution of NaCl and/or 0.2 mg/ml mitomycin-C in nasolacrimal duct obstruction patients.
abstract: OBJECTIVE
  To compare the efficacy of lacrimal probing and syringing among 3% solution of Sodium Chloride and/or 0.2 mg/ ml Mitomycin-C as an adjunctive medication.
  
  
  METHODS
  A prospective, randomized, 2 by 2 factorial design study.
  
  
  METHODS
  Forty-eight of nasolacrimal duct obstruction patients with epiphora symptom were randomly assigned to receive either Normal Saline Solution or 3% solution of Sodium Chloride or 0.2 mg/ml Mitomycin-C solution or combined 3% solution of Sodium Chloride with 0.2 mg/ml Mitomycin-C solution, during office probing and syringing. The intervention was performed repeatedly at week 0, weeks 2 and 4. An assessment of epiphora with Visual Analogue Scale were evaluated at week 0, weeks 2, 4, 8 and 12.
  
  
  RESULTS
  Probing and syringing was successfully reducing epiphora symptom. Mitomycin-C group showed a significant reduction in mean difference of Visual Analogue Scale score compared with Normal Saline Solution group (2.85, 95% CI: 1.164-4.536, p < 0.001) and 3% Sodium Chloride group (2.175, 95% CI: 0.489-3.861, p < 0.01). No complication or adverse event was found.
  
  
  CONCLUSIONS
  0.2 mg/ml Mitomycin-C solution of was the most effective medication for office probing and syringing in reducing epiphora symptom in nasolacrimal duct obstruction patients.
authors.affiliation: Department of Ophthalmology, Phramongkutklao College of Medicine, Bangkok, Thailand. ravee_choon@yahoo.com
authors.forename: Raveewan
authors.initials: R
authors.lastname: Choontanom
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D009301:Nasolacrimal Duct / Q000601:surgery*; D010147:Pain Measurement; D011446:Prospective Studies; D012965:Sodium Chloride / Q000627:therapeutic use; D013594:Syringes; D007507:Therapeutic Irrigation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D012965:Sodium Chloride; D016685:Mitomycin