title: Prostate cancer mortality in Taiwanese men: increasing age-standardized trend in general population and increased risk in diabetic men.
abstract: BACKGROUND
  To evaluate the trend of prostate cancer mortality in Taiwanese general population and the association between diabetes and prostate cancer mortality.
  
  
  METHODS
  In the general population during 1995-2006, the trends of prostate cancer mortality were evaluated, followed by calculation of age-specific mortality rates for age 40-64, 65-74, and ≥ 75 years. A cohort of 102,651 diabetic men aged ≥ 40 years recruited in 1995-1998 was followed prospectively.
  
  
  RESULTS
  The trends of crude and age-standardized mortality from prostate cancer in the general population increased significantly (P < 0.0001). In the general population, 7,966 men aged ≥ 40 years died of prostate cancer, and aging was associated with increased risk. Age-specific prostate cancer mortality suggested significantly increasing trend for ages 65-74 and ≥ 75 years. A total of 321 diabetic men died of prostate cancer (crude mortality rate 41.9/100,000 person-years). Mortality rate ratios (95% confidence interval) showed higher risk of prostate cancer mortality in the diabetic patients, with magnitude increased with decreasing age: 1.55 (1.29-1.86), 2.68 (2.29-3.13), and 6.84 (5.34-8.75) for age ≥ 75, 65-74, and 40-64 years, respectively.
  
  
  CONCLUSIONS
  Prostate cancer mortality in the Taiwanese general population is increasing. Diabetic patients have a higher risk of prostate cancer mortality, which is more remarkable with decreasing age.
authors.affiliation: Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. ccktsh@ms6.hinet.net
authors.forename: Chin-Hsiao
authors.initials: CH
authors.lastname: Tseng
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000401:mortality*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000401:mortality*; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology