title: New QTL for resistance to Salmonella carrier-state identified on fowl microchromosomes.
abstract: Chicken's ability to carry Salmonella without displaying disease symptoms leads to an invisible propagation of Salmonella in poultry stocks. Using chicken lines more resistant to carrier state could improve both animal health and food safety. Previous studies identified several QTL for resistance to carrier state. To improve genome coverage and QTL detection power we produced a new set of 480 informative SNP markers and genotyped a larger number of animals. Ten additional microchromosomes could be covered when compared with previous studies. These new data led to the identification of 18 QTL significant at the chromosome-wide level. The only QTL significant at the genome-wide level were identified on microchromosomes 14 and 22 and have never been identified previously. Using a higher number of animals improved the power and the precision of QTL detection. Some of the QTL newly identified are located close to candidate genes or microsatellite markers previously identified for their involvement in the genetic control of resistance to Salmonella, which confirms their interest for selection purposes.
authors.affiliation: INRA UMR 083 Unité de Recherches Avicoles, 37380 Nouzilly, France. Fanny.Calenge@tours.inra.fr
authors.forename: Fanny
authors.initials: F
authors.lastname: Calenge
authors.forename: Alain
authors.initials: A
authors.lastname: Vignal
authors.forename: Julie
authors.initials: J
authors.lastname: Demars
authors.forename: Katia
authors.initials: K
authors.lastname: Fève
authors.forename: Pierrette
authors.initials: P
authors.lastname: Menanteau
authors.forename: Philippe
authors.initials: P
authors.lastname: Velge
authors.forename: Catherine
authors.initials: C
authors.lastname: Beaumont
mesh_terms: D000818:Animals; D002353:Carrier State / Q000382:microbiology / Q000662:veterinary*; D002645:Chickens / Q000235:genetics* / Q000382:microbiology*; D020641:Polymorphism, Single Nucleotide; D011201:Poultry Diseases / Q000235:genetics* / Q000382:microbiology*; D040641:Quantitative Trait Loci; D012481:Salmonella Infections, Animal / Q000235:genetics*