title: Salese to buffer saliva in elderly patients with xerostomia: a pilot study.
abstract: OBJECTIVE
  The objective of this study was to compare the pH of saliva from xerostomic patients before and after the use of Salese lozenges (Nuvora Inc., Santa Clara, CA).
  
  
  METHODS
  After IRB approval, ten subjects were selected to participate in this pilot study to evaluate the efficacy of Salese. The inclusion criteria were patients on multiple medications who demonstrated xerostomia and acidic salivary pH. Saliva was collected from the patients at baseline and after the use of Salese at selected intervals up to 120 minutes. The pH of the collected saliva was measured, and the data were analyzed using an ANOVA.
  
  
  RESULTS
  Use of Salese lozenges showed a shift toward a more neutral pH in the first half hour. The pH remained at the same level after the primary shift for at least 2 hours.
  
  
  CONCLUSIONS
  This pilot study indicates that patients suffering with xerostomia can use Salese lozenges for at least 10-30 minutes to induce a salivary pH shift to a more neutral level. More research should be performed to investigate the buffering capacity of Salese lozenges.
authors.affiliation: Postgraduate Prosthodontics, Nova Southeastern University College of Dental Medicine, Ft. Lauderdale, FL, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Kharevich
authors.forename: Barry
authors.initials: B
authors.lastname: Shipman
authors.forename: Barry M
authors.initials: BM
authors.lastname: Goldman
authors.forename: Max
authors.initials: M
authors.lastname: Nahon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002021:Buffers; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D019338:Polypharmacy; D012463:Saliva / Q000737:chemistry* / Q000502:physiology; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D013607:Tablets; D014987:Xerostomia / Q000139:chemically induced / Q000188:drug therapy*; D014993:Xylitol / Q000008:administration & dosage*
chemical_list: D002021:Buffers; D013607:Tablets; D017693:Sodium Bicarbonate; D014993:Xylitol