title: Eugenol: a natural compound with versatile pharmacological actions.
abstract: Eugenol, the major constituent of clove oil, has been widely used for its anesthetic and analgesic action in dentistry. Eugenol exhibits pharmacological effects on almost all systems and our aim is to review the research work that has identified these pharmacological actions. Eugenol possesses significant antioxidant, anti-inflammatory and cardiovascular properties, in addition to analgesic and local anesthetic activity. The metabolism and pharmacokinetics of the compound in humans have been studied. Eugenol has also been used as a penetration enhancer. The compound is a very promising candidate for versatile applications, and the design of new drugs based on the pharmacological effects of eugenol could be beneficial.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi - 110 062, India.
authors.forename: Kannissery
authors.initials: K
authors.lastname: Pramod
authors.forename: Shahid H
authors.initials: SH
authors.lastname: Ansari
authors.forename: Javed
authors.initials: J
authors.lastname: Ali
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000777:Anesthetics / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001688:Biological Products / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D005054:Eugenol / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000700:Analgesics; D000777:Anesthetics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001688:Biological Products; D005054:Eugenol