title: Donor transmission of pineoblastoma in a two-yr-old male recipient of a multivisceral transplant: a case report.
abstract: Transplant-transmitted malignances are rare but devastating events. Primary brain tumors are the least common among reported donor-derived malignancies. We report a case of donor-transmitted pineoblastoma, a PNET, in a two-yr-old male recipient, who presented with a rapidly growing mass in the right mandible, four months after multiple visceral organ transplantation. The recipient had liver, pancreas, and small bowel transplants because of end-stage liver failure and short gut syndrome, which was secondary to large bowel resection for management of gastroschisis complicated by intestinal volvulus. The donor autopsy results became available seven wk after transplantation, which found a pineoblastoma with meningeal spread. Evaluation of eyes, adrenal glands, bone marrow, and other organs did not identify metastasis outside the CNS. A biopsy of the recipient's right mandibular mass revealed a malignant small round blue cell tumor with the immunohistochemistry profile of a PNET. Staging evaluation revealed the tumor in the right mandible with bone marrow involvement. Further investigation showed that recipient's tumor and donor's pineoblastoma shared the same immunophenotype and HLA type, suggesting the recipient's tumor is a donor-transmitted pineoblastoma. This is the first case report of donor-transmitted pineoblastoma post-organ transplant.
authors.affiliation: Department of Pathology, Georgetown University Hospital, Washington, DC 20007, USA. po.zhao@gunet.georgetown.edu
authors.forename: Po
authors.initials: P
authors.lastname: Zhao
authors.forename: Alexis
authors.initials: A
authors.lastname: Strohl
authors.forename: Corina
authors.initials: C
authors.lastname: Gonzalez
authors.forename: Thomas
authors.initials: T
authors.lastname: Fishbein
authors.forename: Sandra
authors.initials: S
authors.lastname: Rosen-Bronson
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Kallakury
authors.forename: Metin
authors.initials: M
authors.lastname: Ozdemirli
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology*; D002675:Child, Preschool; D017809:Fatal Outcome; D006801:Humans; D007421:Intestine, Small / Q000637:transplantation*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008339:Mandibular Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000556:secondary; D016035:Pancreas Transplantation / Q000009:adverse effects*; D010870:Pineal Gland; D010871:Pinealoma / Q000175:diagnosis / Q000209:etiology* / Q000556:secondary; D014019:Tissue Donors