title: The analysis of depression and subsequent cancer risk in Taiwan.
abstract: BACKGROUND
  Patients with depression are suggestive of having a tendency toward a marginally significant association with the subsequent cancer risk. The aim of this study was to evaluate the possible relationship between depression and cancer risk in Taiwan.
  
  
  METHODS
  We used the data of the National Health Insurance system of Taiwan to assess this issue. The Cox proportional hazard regression analysis was conducted to estimate the effects of depression on the cancer risk.
  
  
  RESULTS
  In patients with depression, there was no significant change in the risk of developing overall cancer or for the site-specific cancer and all showed the same direction (positive) except for colorectal cancer, which had a negative direction.
  
  
  CONCLUSIONS
  This population-based study did not find Taiwanese patients with depression to have a higher risk to develop overall cancer or site-specific cancer.
  
  
  CONCLUSIONS
  Depression does not increase cancer risk.
authors.affiliation: Department of Radiation Oncology, China Medical University Hospital, and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan.
authors.forename: Ji-An
authors.initials: JA
authors.lastname: Liang
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Sun
authors.forename: Chih-Hsin
authors.initials: CH
authors.lastname: Muo
authors.forename: Fung-Chang
authors.initials: FC
authors.lastname: Sung
authors.forename: Shih-Ni
authors.initials: SN
authors.lastname: Chang
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult