title: Rhodium-catalyzed acylation with quinolinyl ketones: carbon-carbon single bond activation as the turnover-limiting step of catalysis.
abstract: The rhodium-catalyzed intramolecular carboacylation of quinolinyl ketones serves as an ideal subject for the mechanistic study of carbon-carbon bond activation. Combined kinetic and NMR studies of this reaction allowed the identification of the catalytic resting state and determination of the rate law, (12)C/(13)C kinetic isotope effects, and activation parameters. These results have identified the activation of a ketone-arene carbon-carbon single bond as the turnover-limiting step of catalysis and provided quantitative detail into this process.
authors.affiliation: Department of Chemistry, Hope College, Holland, Michigan 49423, United States.
authors.forename: Colin M
authors.initials: CM
authors.lastname: Rathbun
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Johnson