title: Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory.
abstract: Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
authors.affiliation: Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Murray
authors.forename: Jonas-Frederic
authors.initials: JF
authors.lastname: Sauer
authors.forename: Gernot
authors.initials: G
authors.lastname: Riedel
authors.forename: Christina
authors.initials: C
authors.lastname: McClure
authors.forename: Laura
authors.initials: L
authors.lastname: Ansel
authors.forename: Lesley
authors.initials: L
authors.lastname: Cheyne
authors.forename: Marlene
authors.initials: M
authors.lastname: Bartos
authors.forename: William
authors.initials: W
authors.lastname: Wisden
authors.forename: Peer
authors.initials: P
authors.lastname: Wulff
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D007395:Interneurons / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology*; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009483:Neuropsychological Tests; D010320:Parvalbumins / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D013028:Space Perception / Q000502:physiology; D013744:Tetanus Toxin / Q000235:genetics / Q000378:metabolism; D050988:Vesicle-Associated Membrane Protein 2 / Q000235:genetics / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D010320:Parvalbumins; D011993:Recombinant Fusion Proteins; D013744:Tetanus Toxin; D050988:Vesicle-Associated Membrane Protein 2; C494808:vesicle-associated membrane protein 2, mouse; D005680:gamma-Aminobutyric Acid; D008666:Metalloendopeptidases; C093556:zinc-endopeptidase, tetanus neurotoxin