title: 17β-estradiol regulates estrogen receptor α monoubiquitination.
abstract: Monoubiquitination is a nonproteolytic signal involved in a network of several different physiological processes. Recently, monoubiquitination has been discovered as a new post-transductional modification of the estrogen receptor α (ERα). However, at present no information is available about the role of the cognate ligand 17β-estradiol (E2) in modulating this receptor post-transductional modification. Thus, we studied the E2-dependent modulation of ERα monoubiquitination in different cell lines. Here, we report that ERα monoubiquitination isnegatively modulated by E2. These results demonstrate thatERα monoubiquitination represents a new signalling modification that may modulate the E2:ERα-regulated cellular processes.
authors.affiliation: Department of Biology, University Roma Tre, Viale Guglielmo Marconi, 446, Rome, Italy.
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: La Rosa
authors.forename: Maria
authors.initials: M
authors.lastname: Marino
authors.forename: Filippo
authors.initials: F
authors.lastname: Acconcia
mesh_terms: D045744:Cell Line, Tumor; D004958:Estradiol / Q000494:pharmacology*; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D006801:Humans; D018613:Microscopy, Confocal; D025801:Ubiquitin / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D047628:Estrogen Receptor alpha; D025801:Ubiquitin; D004958:Estradiol