title: [Diversity of incidence trend patterns: implications for carcinogenesis?].
abstract: OBJECTIVE
  Cancers of the ENT, oesophagus and lungs are caused mainly by alcohol and/or tobacco consumption but have potentially heterogeneous latencies and dose-incidence relationships. The incidence of cancers having the same risk factors may vary in a similar way over time and space. The aim of the study was to identify groups of cancers with similar spatio-temporal incidence trends.
  
  
  METHODS
  Fifty thousand nine hundred and eighty cases of ten cancer types were collected between 1982 and 2002 in six French departments. The incidence levels and trends were assessed using an age-cohort random-effect model that took into account heterogeneity of incidence levels and trends between departments.
  
  
  RESULTS
  Three groups of cancer sites/types with similar spatio-temporal incidence trends were identified: (1) oral cavity, oropharynx, hypopharynx, larynx, oesophagus, and lung squamous cell carcinomas in which the incidence decreased similarly in time and space; (2) other types of lung cancer and lung adenocarcinomas whose incidence increased similarly; and (3) lung large- and small-cell carcinomas whose incidence trends were heterogeneous.
  
  
  CONCLUSIONS
  Using the tools of descriptive epidemiology different cancer groups with different temporal and spatial incidence trends were identified. This diversity suggests different latencies and different sensitivities of those groups to the main risk factors, alcohol and tobacco.
authors.affiliation: Service de Biostatistique des Hospices Civils de Lyon, Bat 4D, Centre Hospitalier Lyon Sud, 69495 Pierre-Bénite, France. guillaume.buiret@laposte.net
authors.forename: G
authors.initials: G
authors.lastname: Buiret
authors.forename: G
authors.initials: G
authors.lastname: Launoy
authors.forename: L
authors.initials: L
authors.lastname: Remontet
authors.forename: N
authors.initials: N
authors.lastname: Bossard
authors.forename: J
authors.initials: J
authors.lastname: Iwaz
authors.forename: A
authors.initials: A
authors.lastname: Belot
authors.forename: R
authors.initials: R
authors.lastname: Ecochard
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D003430:Cross-Sectional Studies; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D005260:Female; D005602:France; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology