title: Impact of induced pluripotent stem cells on the study of central nervous system disease.
abstract: The derivation of pluripotent stem cells from somatic tissues has provided researchers with a source of patient-specific stem cells. The potential applications of this technology are truly momentous, and include cellular modeling of disease processes, drug discovery, and cell-based therapy. Here, we review the use of induced pluripotent stem cells (iPSCs) to study CNS disease. Since the iPSC field is still in its infancy, we also discuss some of the challenges that will need to be overcome before the potential of this technology to study and to treat neurological and psychiatric disorders can be fully harnessed.
authors.affiliation: Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA.
authors.forename: Paige E
authors.initials: PE
authors.lastname: Cundiff
authors.forename: Stewart A
authors.initials: SA
authors.lastname: Anderson
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics; D017204:Angelman Syndrome / Q000235:genetics; D002493:Central Nervous System Diseases / Q000235:genetics*; D004402:Dysautonomia, Familial / Q000235:genetics; D005600:Fragile X Syndrome / Q000235:genetics; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D009134:Muscular Atrophy, Spinal / Q000235:genetics / Q000628:therapy; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics; D011218:Prader-Willi Syndrome / Q000235:genetics; D015518:Rett Syndrome / Q000235:genetics