title: Propranolol for the treatment of orbital infantile hemangiomas.
abstract: OBJECTIVE
  To evaluate the treatment of orbital infantile hemangiomas with systemic (oral) propranolol.
  
  
  METHODS
  This study was a retrospective observational case series of 5 infants who were diagnosed with orbital infantile hemangiomas between March and July of 2009.
  
  
  RESULTS
  The average age at presentation was 3.1 months (3 weeks to 9 months). The patients received oral propranolol, with dosage varying among study centers. The patients were treated for an average of 7.1 months. Treatment of 5 infantile hemangioma patients with oral propranolol produced a significant reduction in the size of the hemangioma in 4 (80%) of the patients and a minimal improvement in one patient. No patient had significant adverse events during the treatment period.
  
  
  CONCLUSIONS
  Oral propranolol may be an effective treatment for orbital infantile hemangiomas.
authors.affiliation: Department of Ophthalmology, University of South Florida College of Medicine, Tampa, Florida, USA.
authors.forename: Gretta
authors.initials: G
authors.lastname: Fridman
authors.forename: Eric
authors.initials: E
authors.lastname: Grieser
authors.forename: Robert
authors.initials: R
authors.lastname: Hill
authors.forename: Nausheen
authors.initials: N
authors.lastname: Khuddus
authors.forename: Tom
authors.initials: T
authors.lastname: Bersani
authors.forename: Charles
authors.initials: C
authors.lastname: Slonim
mesh_terms: D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D018324:Hemangioma, Capillary / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009918:Orbital Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011433:Propranolol / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D000970:Antineoplastic Agents; D011433:Propranolol