title: Successful S-1 monotherapy for chemorefractory thymic carcinoma.
abstract: The optimal chemotherapeutic regimen for inoperable thymic carcinoma remains uncertain and little information is available regarding the usefulness of salvage chemotherapy. S-1, a newly developed oral fluorouracil antitumor drug, has been reported to be effective in the treatment of gastrointestinal tumors and non-small cell lung cancer. This case study reports a case of chemorefractory thymic cancer with a good response to S-1 monotherapy. S-1 was used as sixth-line chemotherapy and the response was the first remarkable tumor regression in the patient's clinical course. S-1 appears to have significant activity against thymic carcinoma.
authors.affiliation: Comprehensive Cancer Center, Division of Clinical Oncology, Shinshu University Hospital, Asahi Matsumoto, Japan. tomonobu@shinshu-u.ac.jp
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Yoshimichi
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D004338:Drug Combinations; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D016879:Salvage Therapy; D005641:Tegafur / Q000627:therapeutic use*; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid