title: Solitary metastasis of a clear cell ovarian adenocarcinoma to the small bowel mucosa.
abstract: Metastasis of ovarian carcinoma to the small bowel parenchyma without peritoneal dissemination is uncommon. A 63-year-old woman underwent surgery for a clear cell adenocarcinoma of the ovary and received adjuvant chemotherapy. Eighteen months after the operation, she presented with recurrent occult bowel hemorrhage without evidence of an abdominal mass. Nine months later, a rapidly growing abdominal mass was detected. Laparoscopy revealed a solitary tumor of the ileum covered with an intact serosal layer. Partial ileectomy was performed for tumor resection. Histological examination revealed cells resembling the primary ovarian tumor in the mucosal surface of the small bowel along with an intact serosa. The tumor cells were positive for cytokeratin 7 and negative for cytokeratin 20, suggesting an ovarian origin. This is the first report of solitary metastasis of an ovarian carcinoma to the small bowel parenchyma without peritoneal dissemination. Metastasis to the small bowel should be considered in ovarian carcinoma patients with occult gastrointestinal hemorrhage.
authors.affiliation: Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Mitsuhashi
authors.forename: Naotake
authors.initials: N
authors.lastname: Tanaka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nagai
authors.forename: Makio
authors.initials: M
authors.lastname: Shozu
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology / Q000556:secondary*; D007413:Intestinal Mucosa / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*