title: Research on component law of Chinese patent medicine for anti-influenza and development of new recipes for anti-influenza by unsupervised data mining methods.
abstract: OBJECTIVE
  To analyze the component law of Chinese patent medicines for anti-influenza and develop new prescriptions for anti-influenza by unsupervised data mining methods.
  
  
  METHODS
  Chinese patent medicine recipes for anti-influenza were collected and recorded in the database, and then the correlation coefficient between herbs, core combinations of herbs and new prescriptions were analyzed by using modified mutual information, complex system entropy cluster and unsupervised hierarchical clustering, respectively.
  
  
  RESULTS
  Based on analysis of 126 Chinese patent medicine recipes, the frequency of each herb occurrence in these recipes, 54 frequently-used herb pairs, 34 core combinations were determined, and 4 new recipes for influenza were developed.
  
  
  CONCLUSIONS
  Unsupervised data mining methods are able to mine the component law quickly and develop new prescriptions.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
authors.forename: Shi-Huan
authors.initials: SH
authors.lastname: Tang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Chen
authors.forename: Geng
authors.initials: G
authors.lastname: Li
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Wu
authors.forename: Chang
authors.initials: C
authors.lastname: Chen
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: Gao
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Yang
authors.forename: Lu-Qi
authors.initials: LQ
authors.lastname: Huang
mesh_terms: D000998:Antiviral Agents / Q000032:analysis* / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D057225:Data Mining; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000627:therapeutic use; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000502:physiology; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D004366:Nonprescription Drugs / Q000032:analysis* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D004366:Nonprescription Drugs