title: [Occurrence and relevance to health of persistent organic substances and phthalates in breast milk].
abstract: The aim of this study is to give an overview of the concentrations of persistent organic pollutants like the polychlorinated dibenzo- P-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), polychlorinated biphenyls (PCB), polybrominated diphenyl ether (PBDE), perfluorinated compounds (PFC) and of phthalates in breast milk. On the basis of median and 95 (th) percentile values an "average" and a "high" intake were calculated for a 3-month-old infant exclusively breast-fed. Moreover, the actual daily intake was compared with tolerable daily intakes (TDI) recommended by scientific institutions. On this basis, we found an "average" ("high") daily intake of 70 (140) pg TEQ/kg body weight (b. w.) for PCDD/F and dioxin-like PCB (dl-PCB), 10 (20) ng/kg b. w. for PFOS (perfluorooctanesulfonate), 20 (50) ng/kg b. w. for PFOA (perfluorooctanoate), 1.7 (7.5) ng/kg b. w. for BDE 47, and 0.6 (2.1) ng/kg b. w. for BDE 99. For di-2-ethylhexyl phthalate (DEHP) and di- N-butyl phthalate (DnBP) an "average" and "high" intake of 400 ng/kg b. w. and 2,000 ng/kg b. w. and of 100 and 500 ng/kg b.w. were assumed, respectively. For all of these substances we found a daily intake via breast milk below the TDI, established on a livelong basis. On contrary, the daily intake for the sum of the PCDD/F and dl-PCB considerably exceeded the recommended TDI value. Even with regard to the "high" daily intake values the share of PBDE, PFC, and phthalates on the TDI was only in the lower percentage. Scientific organisations assume that an exceeding of the PCDD/F and dl-PCB intake in relation to the TDI value is acceptable only on the basis of the still declining levels in breast milk and the fact that this high exposure only occurs during some months of the entire life when breast milk is consumed. On the basis of the recent exposure situation mothers can exclusively breast-feed their infants for 6 months without any hesitation. The well established health benefits for mothers and infants when exclusively breast-feeding should be utilised. There is also no health concern if the mother decides to breast-feed the baby for longer than 6 months when the infant also receives additional food.
authors.affiliation: Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Sachgebiet Chemikaliensicherheit und Toxikologie/Biomonitoring München. hermann.fromme@lgl.bayern.de
authors.forename: H
authors.initials: H
authors.lastname: Fromme
authors.forename: U
authors.initials: U
authors.lastname: Raab
authors.forename: P
authors.initials: P
authors.lastname: Fürst
authors.forename: B
authors.initials: B
authors.lastname: Vieth
authors.forename: W
authors.initials: W
authors.lastname: Völkel
authors.forename: M
authors.initials: M
authors.lastname: Albrecht
authors.forename: U
authors.initials: U
authors.lastname: Schwegler
mesh_terms: D001822:Body Burden; D004785:Environmental Pollutants / Q000032:analysis*; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000737:chemistry*; D009930:Organic Chemicals / Q000032:analysis*; D010795:Phthalic Acids / Q000032:analysis*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D004785:Environmental Pollutants; D009930:Organic Chemicals; D010795:Phthalic Acids; C032279:phthalic acid