title: Protein kinase C isoforms in neutrophil adhesion and activation.
abstract: Neutrophils are the first line of defense against bacterial and mycotic pathogens. In order to reach the pathogens, neutrophils need to transmigrate through the vascular endothelium and migrate to the site of infection. Defense strategies against pathogens include phagocytosis, production and release of oxygen radicals through the oxidative burst, and degranulation of antimicrobial and inflammatory molecules. Protein kinase C (PKC)-δ is required for full assembly of NADPH oxidase and activation of the respiratory burst. Neutrophils also express PKC-α and -β, which may be involved in adhesion, degranulation and phagocytosis, but the evidence is not conclusive yet. This review focuses on the potential impact of protein kinase C isoforms on neutrophil adhesion and activation.
authors.affiliation: Department of Nephrology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Bertram
authors.forename: Klaus
authors.initials: K
authors.lastname: Ley
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D015550:Cell Degranulation; D006801:Humans; D007527:Isoenzymes; D036904:Leukocyte Rolling; D018375:Neutrophil Activation; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D010587:Phagocytosis; D011493:Protein Kinase C / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000378:metabolism; D016897:Respiratory Burst; D019087:Selectins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D007527:Isoenzymes; D019707:Receptors, Chemokine; D019087:Selectins; D011493:Protein Kinase C