title: Serum peptide YY in response to short-term overfeeding in young men.
abstract: BACKGROUND
  Peptide YY (PYY), a gut hormone that inhibits appetite, has been linked to the development of obesity.
  
  
  OBJECTIVE
  This study investigated the nutritional regulation of PYY after 7 d of overfeeding (70% above normal energy requirements) in normal-weight, overweight, and obese men.
  
  
  METHODS
  Sixty-nine men (aged 19-29 y) participated in the study. We analyzed the relation between fasting serum PYY before and after a 7-d overfeeding challenge in normal-weight, overweight, and obese men. In addition, we analyzed PYY with obesity-related phenotypes including weight, percentage body fat (measured by dual-energy X-ray absorptiometry), body mass index (BMI), total cholesterol, HDL, LDL, glucose, insulin, insulin resistance, and β cell function evaluated by the homeostasis model assessment of insulin resistance (HOMA-IR) and β cell function (HOMA-β) at baseline and in response to the energy surplus.
  
  
  RESULTS
  Fasting serum PYY concentrations at baseline were not significantly different between the normal-weight, overweight, and obese subjects on the basis of dual-energy X-ray absorptiometry or BMI. Although the PYY concentration significantly increased due to overfeeding, no differences were observed between adiposity statuses. In addition, basal PYY was negatively correlated with the changes of total cholesterol, HDL, and LDL in normal weight. In addition, the increase in PYY after overfeeding was positively correlated with HDL cholesterol and glucose in normal-weight subjects.
  
  
  CONCLUSIONS
  Our findings suggest that fasting PYY concentrations are not associated with adiposity status. Moreover, the 7-d overfeeding challenge significantly increased fasting PYY, which is likely a protective response to the positive energy balance.
authors.affiliation: Division of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John's, Canada.
authors.forename: Farrell
authors.initials: F
authors.lastname: Cahill
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Shea
authors.forename: Edward
authors.initials: E
authors.lastname: Randell
authors.forename: Sudesh
authors.initials: S
authors.lastname: Vasdev
authors.forename: Guang
authors.initials: G
authors.lastname: Sun
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood*; D002149:Energy Intake; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood; D044343:Overnutrition / Q000097:blood*; D050177:Overweight / Q000097:blood; D019894:Peptide YY / Q000097:blood*; D012016:Reference Values; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D019894:Peptide YY; D002784:Cholesterol