title: Prognostic assessment in COPD: health related quality of life and the BODE index.
abstract: BACKGROUND
  COPD is a debilitating disease with increasing mortality worldwide. The BODE index evaluates disease severity and the St George's Respiratory Questionnaire (SGRQ) measures health status.
  
  
  OBJECTIVE
  To identify the relationship between BODE index and the SGRQ and to test the predictive value of both tools against survival.
  
  
  METHODS
  Open cohort study of 1398 COPD patients (85% male) followed for up to 10 years.
  
  
  RESULTS
  At the time of the inclusion, clinical data, forced spirometry and 6 min walking distance were determined and BODE index and SGRQ were calculated. Vital status and cause of death were documented at the end of follow-up.
  
  
  RESULTS
  The cohort's mean of FEV1% predicted was 46 ± 18%, BODE index was 3.6 ± 2.5, and SGRQ% total score was 49 ± 20. The SGRQ scores increased progressively as severity of COPD increased by BODE quartiles. The correlation between SGRQ and BODE index was good (r = 0.58, p < 0.0001). Both tests correlated with COPD survival (BODE = -0.4 vs. SGRQ = -0.20, p < 0.0001). The area under the curve (AUC) for the BODE index was 0.77 vs. 0.66 for the SGRQ % total score (p < 0.001).
  
  
  CONCLUSIONS
  Health status as measured by SGRQ worsens with disease severity evaluated by the BODE index. Both tools predict mortality and provide complimentary information in the evaluation of patients with COPD.
authors.affiliation: Hospital Universitario Miguel Servet, Instituto Aragones Ciencias Salud & CIBERES, Zaragoza, Spain. jmmarint@unizar.es
authors.forename: Jose M
authors.initials: JM
authors.lastname: Marin
authors.forename: Claudia G
authors.initials: CG
authors.lastname: Cote
authors.forename: Orlando
authors.initials: O
authors.lastname: Diaz
authors.forename: Carmen
authors.initials: C
authors.lastname: Lisboa
authors.forename: Ciro
authors.initials: C
authors.lastname: Casanova
authors.forename: Maria V
authors.initials: MV
authors.lastname: Lopez
authors.forename: Santiago J
authors.initials: SJ
authors.lastname: Carrizo
authors.forename: Victor
authors.initials: V
authors.lastname: Pinto-Plata
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Dordelly
authors.forename: Hafida
authors.initials: H
authors.lastname: Nekach
authors.forename: Bartolome R
authors.initials: BR
authors.lastname: Celli
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015331:Cohort Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000401:mortality / Q000503:physiopathology* / Q000523:psychology; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index; D013147:Spirometry / Q000379:methods*; D011795:Surveys and Questionnaires