title: [Efficacy of recombinant activated factor VII in diffuse alveolar haemorrhage].
abstract: BACKGROUND
  Alveolar haemorrhage is a serious complication of a range of different pathologies. Published recent literature has reported only cases unresponsive to the usual treatment (steroids, transfusions, immunosuppressors and mechanical ventilation) as well as multiple secondary complications of these kinds of therapies. Recombinant activated factor VII (rF VIIa) is a new class of agent, which appears to be a successful adjunct therapy in the case of failure of conventional treatments.
  
  
  METHODS
  We describe two cases of alveolar haemorrhage treated with rF VIIa. The first patient had leukaemia and the second had ANCA-associated granulomatous vasculitis. Both were admitted to the intensive care unit for mechanical ventilation with persistent diffuse alveolar haemorrhage that responded only to a single dose of rF VIIa (90 μg/kg).
  
  
  CONCLUSIONS
  rF VIIa is a promising treatment for diffuse, persistent alveolar haemorrhage, with only a small dose required to be effective. Future studies are needed in order to establish a clear protocol for the administration of this novel agent.
authors.affiliation: Service de Pneumologie et Réanimation Médicale, Hôpital Hôtel-Dieu de France, BP 16-6830, boulevard Alfred-Naccache, Achrafieh, Beyrouth, Liban. georges.dabar@hdf.usj.edu.lb
authors.forename: G
authors.initials: G
authors.lastname: Dabar
authors.forename: C
authors.initials: C
authors.lastname: Harmouche
authors.forename: M
authors.initials: M
authors.lastname: Jammal
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity; D001792:Blood Platelets / Q000187:drug effects; D016465:Bone Marrow Purging; D015942:Factor VIIa / Q000627:therapeutic use*; D014890:Granulomatosis with Polyangiitis / Q000150:complications; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D008171:Lung Diseases / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011650:Pulmonary Alveoli; D011994:Recombinant Proteins / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa