title: Long-term consequences of the early treatment of children with congenital hypothyroidism detected by neonatal screening in Nanjing, China: a 12-year follow-up study.
abstract: This study was performed to investigate the prevalence of congenital hypothyroidism (CH) in neonates in Nanjing, China and the long-term consequences of early treatment. A total of 442 454 neonates were screened for CH and 183 neonates were confirmed, with a prevalence of 1 in 2418. Of these, 163 neonates completed the follow-up process and 163 healthy children were recruited as the control group. The height, weight and body mass index (BMI) of the children with CH from 0.5 to 6 years were not significantly different from the control group (p > 0.05). The children with CH had a significantly increased risk for being overweight or obese between 0.5 and 6 years (p < 0.05). The children with CH showed a significantly lower developmental quotient (DQ) than the control group in all four areas of the Gesell test (p < 0.05). The results suggest that children with CH that has been identified by newborn screening and early treatment have normal growth and neuromotor development.
authors.affiliation: Department of Pediatrics, Nanjing Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Sun
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Chen
authors.forename: Zhang-Bin
authors.initials: ZB
authors.lastname: Yu
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Han
authors.forename: Xiao-Yue
authors.initials: XY
authors.lastname: Dong
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Qiu
authors.forename: Li
authors.initials: L
authors.lastname: Sha
authors.forename: Xi-Rong
authors.initials: XR
authors.lastname: Guo
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007361:Intelligence Tests; D008297:Male; D015997:Neonatal Screening; D015995:Prevalence; D011446:Prospective Studies