title: Ictal very low frequency oscillation in human epilepsy patients.
abstract: Using intracranial electroencephalographic recordings, we identified a distinct brain activity in 3 patients with refractory epilepsy characterized by very early occurrence from 8 minutes 10 seconds to 22 minutes 40 seconds prior to clinical seizure onset, periodical appearance of slow negative baseline shift, long interpeak interval of 40 to 120 seconds, and disappearance after clinical seizure. We named this activity "very low frequency oscillation" (VLFO), which reflected a dynamic process during the preictal state. This observation may render new insight into epileptogenesis and provide additional information concerning the epileptogenic zone as well as prediction of epileptic seizures.
authors.affiliation: Department of Neurology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Liankun
authors.initials: L
authors.lastname: Ren
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Terada
authors.forename: Koichi
authors.initials: K
authors.lastname: Baba
authors.forename: Naotaka
authors.initials: N
authors.lastname: Usui
authors.forename: Shuichi
authors.initials: S
authors.lastname: Umeoka
authors.forename: Keiko
authors.initials: K
authors.lastname: Usui
authors.forename: Kazumi
authors.initials: K
authors.lastname: Matsuda
authors.forename: Takayasu
authors.initials: T
authors.lastname: Tottori
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Nakamura
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Mihara
authors.forename: Yushi
authors.initials: Y
authors.lastname: Inoue
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data*; D004827:Epilepsy / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D019579:Neocortex / Q000503:physiopathology* / Q000601:surgery; D011300:Preoperative Care / Q000706:statistics & numerical data