title: Analysis of molecular interactions in solid dosage forms; challenge to molecular pharmaceutics.
abstract: The molecular states of active pharmaceutical ingredients (APIs) in pharmaceutical dosage forms strongly affect the properties and quality of a drug. Various important fundamental physicochemical studies were reviewed from the standpoint of molecular pharmaceutics. Mechanochemical effects were evaluated in mixtures of APIs and pharmaceutical additives. Amorphization, complex formation and nanoparticle formation are observed after grinding process depending on the combination of APIs and pharmaceutical additives. Sealed-heating method and mesoporous materials have been used to investigate drug molecular interactions in dosage forms. Molecular states have been investigated using powder X-ray diffraction, thermal analysis, IR, solid state fluorometry, and NMR.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chiba, Japan. k-yamamoto@faculty.chiba-u.jp
authors.forename: Keiji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Waree
authors.initials: W
authors.lastname: Limwikrant
authors.forename: Kunikazu
authors.initials: K
authors.lastname: Moribe
mesh_terms: D000818:Animals; D004304:Dosage Forms; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations