title: Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties.
abstract: Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.
authors.affiliation: Laboratory of Chemistry MaNaPro, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok, Russia.
authors.forename: Larisa K
authors.initials: LK
authors.lastname: Shubina
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Makarieva
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dyshlovoy
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Fedorov
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009287:Naphthyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D009287:Naphthyridines; C043986:aaptamine