title: A fever-like effect of central infusion of CNTF in freely moving mice with diet-induced obesity.
abstract: Ciliary neurotrophic factor (CNTF), an inducer of neurogenesis in the hypothalamus, has been known to cause a permanent fall of body mass in mice made obese by a fat-rich diet. In the present study, energetics of obese mice was followed during and after a 7-days long intracerebroventricular infusion of CNTF (720 ng/day) using an ALZET minipump. The animals were previously implanted with MINIMITTER biotelemetry transmitter allowing monitoring of abdominal core temperature (Tc) and locomotor activity (Act). The fat-rich diet induced a rise in body mass by about 40% over a period of 2 months and led to a prompt decrease of circadian Tc excursions by about 50% and an increase of 24-h Tc averages without a change in Act. Infusion of CNTF resulted in an expected reduction of body mass of obese mice beyond the period of infusion. This response was accompanied by a rise in daily averages of Tc together with a decrease in daily Tc excursions and a fall in Act. The observed fall of body mass, rise of Tc and probably a decrease of food intake belong to the components of sickness behaviour.
authors.affiliation: Department of Pathophysiology and Gerontology, Faculty of Medicine, University of Pécs, Szigeti str. 12, 7624 Pécs, Hungary.
authors.forename: Margit
authors.initials: M
authors.lastname: Solymár
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szelényi
authors.forename: Erika
authors.initials: E
authors.lastname: Pétervári
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D020934:Ciliary Neurotrophic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet / Q000009:adverse effects*; D004435:Eating / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D057967:Infusions, Intraventricular; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology*
chemical_list: D020934:Ciliary Neurotrophic Factor