title: The impact of diabetes mellitus in mortality of patients with compensated liver cirrhosis-a prospective study.
abstract: BACKGROUND
  It has been suggested that DM may reduce survival of patients with liver cirrhosis (LC). Nevertheless only few prospective studies assessing the impact of DM on mortality of cirrhotic patients have been published, none in compensated LC.
  
  
  OBJECTIVE
  (i) to study the impact of DM on mortality and (ii) to identify predictors of death.
  
  
  METHODS
  Patients with compensated LC with and without DM were studied. Survival was analyzed by the Kaplan-Meier Method. Univariate and multivariate analysis was performed to determine independent predictors of mortality.
  
  
  RESULTS
  110 patients were included: 60 without DM and 50 with DM. Diabetic patients had significantly higher frequency of cryptogenic cirrhosis, anemia, hypoalbuminemia, and hypercreatininemia. They also had significantly higher BMI and Child-Pugh score. The 2.5-years cumulative survival was significantly lower in patients with DM (48 vs. 69%, p < 0.05). By univariate analysis: DM, female gender, serum creatinine > 1.5 mg/dL, Child-Pugh score class C and cryptogenic cirrhosis were significant. However, only serum creatinine > 1.5 mg/dL and Child-Pugh score class C were independent predictors of death.
  
  
  CONCLUSIONS
  DM was associated with a significant increase in mortality in patients with compensated liver cirrhosis. Serum creatinine > 1.5 mg/dL and Child-Pugh score class C were independent predictors of death.
authors.affiliation: Gastroenterology Service, Department of Internal Medicine, University Hospital, "Dr. José Eleuterio González" Faculty of Medicine, Universidad Autónoma de Nuevo León, Mexico.
authors.forename: Joel Omar Jáquez
authors.initials: JO
authors.lastname: Quintana
authors.forename: Diego
authors.initials: D
authors.lastname: García-Compean
authors.forename: Jose Alberto González
authors.initials: JA
authors.lastname: González
authors.forename: Jesús Zacarías Villarreal
authors.initials: JZ
authors.lastname: Pérez
authors.forename: Fernando Javier Lavalle
authors.initials: FJ
authors.lastname: González
authors.forename: Linda Elsa Muñoz
authors.initials: LE
authors.lastname: Espinosa
authors.forename: Pedro López
authors.initials: PL
authors.lastname: Hernández
authors.forename: Erick Reyes
authors.initials: ER
authors.lastname: Cabello
authors.forename: Edgar Redondo
authors.initials: ER
authors.lastname: Villarreal
authors.forename: Ricardo Flores
authors.initials: RF
authors.lastname: Rendón
authors.forename: Héctor Maldonado
authors.initials: HM
authors.lastname: Garza
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008107:Liver Diseases / Q000097:blood / Q000401:mortality* / Q000473:pathology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D003404:Creatinine