title: Mycobacterium tuberculosis can utilize heme as an iron source.
abstract: Most iron in mammals is found within the heme prosthetic group. Consequently, many bacterial pathogens possess heme acquisition systems to utilize iron from the host. Here, we demonstrate that Mycobacterium tuberculosis can utilize heme as an iron source, suggesting that M. tuberculosis possesses a yet-unknown heme acquisition system.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, 609 Bevill Biomedical Research Building, 845 19th Street South, Birmingham, AL 35294, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Jones
authors.forename: Michael
authors.initials: M
authors.lastname: Niederweis
mesh_terms: D005290:Ferric Compounds / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D006427:Hemin / Q000737:chemistry / Q000378:metabolism*; D007501:Iron / Q000737:chemistry / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D010957:Plasmids; D017262:Siderophores / Q000235:genetics / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism
chemical_list: D005290:Ferric Compounds; D017262:Siderophores; D014168:Transferrin; C025314:ferric citrate; D006427:Hemin; D007501:Iron