title: Phenelfamycins G and H, new elfamycin-type antibiotics produced by Streptomyces albospinus Acta 3619.
abstract: Phenelfamycins G and H are new members of the family of elfamycin antibiotics with the basic structure of phenelfamycins E and F, respectively, which are also well known as ganefromycins α and β. Phenelfamycins G and H differ from phenelfamycins E and F by an additional hydroxy group at position C-30, which is not described so far for any of the elfamycin-type antibiotics. The actinomycete strain that produced phenelfamycins G and H was identified to be Streptomyces albospinus based on its 16S rRNA gene sequence. Phenelfamycins G and H exhibit a narrow antibacterial spectrum with a pronounced inhibitory activity against Propionibacterium acnes.
authors.affiliation: Institut für Organische Chemie II, Universität Siegen, Siegen, Germany.
authors.forename: Elke
authors.initials: E
authors.lastname: Brötz
authors.forename: Andreas
authors.initials: A
authors.lastname: Kulik
authors.forename: Sabaratnam
authors.initials: S
authors.lastname: Vikineswary
authors.forename: Chew-Theng
authors.initials: CT
authors.lastname: Lim
authors.forename: Geok Yuan Annie
authors.initials: GY
authors.lastname: Tan
authors.forename: Heidi
authors.initials: H
authors.lastname: Zinecker
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
authors.forename: Thomas
authors.initials: T
authors.lastname: Paululat
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C558371:phenelfamycin G; C558372:phenelfamycin H