title: Two cases of adenosquamous carcinoma of the cervix with extensive in situ and invasive endometrial extension.
abstract: Adenosquamous carcinoma of the cervix is rare. It is defined as having both glandular and squamous cell differentiation, each component malignant and clearly seen on haematoxylin and eosin-stained slides alone. We report two cases of adenosquamous carcinoma of the uterine cervix, both of which showed in situ and invasive components and both of which showed cephalad extension to involve the endometrium with invasive squamous and adenocarcinomatous components. The mechanisms for cephalad endomyometrial extension is discussed, as are the potential implications for management and staging.
authors.affiliation: Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, The University of Sydney, Sydney, NSW, Australia. clim@dhm.com.au
authors.forename: Cathy
authors.initials: C
authors.lastname: Lim
authors.forename: Tamazin
authors.initials: T
authors.lastname: Leecy
authors.forename: Paul
authors.initials: P
authors.lastname: McKenzie
authors.forename: Selvan
authors.initials: S
authors.lastname: Pather
authors.forename: Jonathan
authors.initials: J
authors.lastname: Carter
authors.forename: Peter
authors.initials: P
authors.lastname: Russell
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology*; D018196:Carcinoma, Adenosquamous / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000473:pathology*