title: Inspiratory muscle training in bronchiectasis patients: a prospective randomized controlled study.
abstract: OBJECTIVE
  To investigate the efficacy and feasibility of home-based inspiratory muscle training in patients with bronchiectasis.
  
  
  METHODS
  A prospective, single-blind, randomized, controlled study.
  
  
  METHODS
  Outpatient clinic of a tertiary care medical centre.
  
  
  METHODS
  Twenty-six patients with bronchiectasis were randomly divided into inspiratory muscle training and control groups. In the inspiratory muscle training group (n = 13), the training programme started with an intensity of 30% maximal inspiratory pressure (MIP), which was increased by 2 cmH(2)O each week, for 30 minutes daily, 5 days a week for eight weeks. The control group (n = 13) did not receive inspiratory muscle training. Main outcome measures included spirometry, resting oxyhaemoglobin saturation by pulse oximetry (SpO(2)), lowest SpO(2) and Borg Scale during 6-minute walking tests, 6-minute walking distance (6MWD), 6-minute walking work (6M(work)), MIP, maximal expiratory pressure (MEP) and St George's Respiratory Questionnaire.
  
  
  RESULTS
  There were significant differences in change from baseline in 6MWD (411.9 (133.5) vs. 473.2 (117.2) m, P = 0.021), 6M(work) (21 051.0 (8286.7) vs. 23 915.5 (8343.0) kg-m, P = 0.022), MIP (60.8 (21.8) vs. 84.6 (29.0) cmH(2)O, P = 0.004), and MEP (72.3 (31.1) vs. 104.2 (35.7) cmH(2)O, P = 0.004) in the inspiratory muscle training group. Significant improvements in both MIP (23.8 (25.3) vs. 2.3 (16.4) cmH(2)O, adjusted P-value = 0.005) and MEP (31.9 (30.8) vs. 11.5 (20.8) cmH(2)O, adjusted P-value = 0.038) levels after adjusting for age by linear regression analysis were observed between groups.
  
  
  CONCLUSIONS
  An eight-week home-based inspiratory muscle training is feasible and effective in improving both inspiratory and expiratory muscle strength, but has no effect on respiratory function and quality of life in patients with bronchiectasis.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Mei-Yun
authors.initials: MY
authors.lastname: Liaw
authors.forename: Yi-Hsi
authors.initials: YH
authors.lastname: Wang
authors.forename: Yu-Chin
authors.initials: YC
authors.lastname: Tsai
authors.forename: Kuo-Tung
authors.initials: KT
authors.lastname: Huang
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Chang
authors.forename: Yung-Che
authors.initials: YC
authors.lastname: Chen
authors.forename: Meng-Chih
authors.initials: MC
authors.lastname: Lin
mesh_terms: D001945:Breathing Exercises; D001987:Bronchiectasis / Q000503:physiopathology / Q000534:rehabilitation*; D005240:Feasibility Studies; D005260:Female; D006699:Home Care Services; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods; D011446:Prospective Studies; D011788:Quality of Life; D012129:Respiratory Function Tests / Q000379:methods*; D018434:Sickness Impact Profile; D016138:Walking / Q000502:physiology*