title: Prolonged use of thromboprophylaxis may not be necessary in laparoscopic colorectal surgery.
abstract: OBJECTIVE
  Patients undergoing colorectal resections are considered high risk for developing thromboembolic disease. We postulate, however, that the rapid recovery and swift mobilization after laparoscopic resections reduce this risk and that these patients therefore do not need prolonged thromboprophylaxis. This hypothesis was tested in this paper.
  
  
  METHODS
  All patients who underwent laparoscopic colorectal surgery in our Colorectal Surgical Unit in the period from June 1991 until January 2010 were entered into a prospective database. The entire database was reviewed, and incidence of thromboembolic disease and significant bleeding complications were noted.
  
  
  RESULTS
  Three thousand, three hundred sixty-four patients were laparoscopically operated on for colorectal disease and were entered in the database. Two thousand, one hundred twenty-seven patients were operated on for benign disease; 1,230, for colorectal cancer, and four, for other malignancies. Two deep venous thromboses were encountered (0.059%), and ten patients had pulmonary embolism (0.30%). The combined venous thromboembolism (VTE) risk for the overall group of patients undergoing laparoscopic colorectal operations is 0.36%. The combined VTE risk was 0.57% (7/1,230) in patients with colorectal cancer and 0.24% (5/2,127) in patients with benign disease (p = 0.118). Bleeding complications occurred in 44 patients (1.3%).
  
  
  CONCLUSIONS
  In our group, the combined VTE risk for the overall group of patients undergoing laparoscopic colorectal operations is 0.36%. Therefore, we postulate that the prolonged use of thromboprophylaxis is not indicated in the vast majority of patients undergoing laparoscopic colorectal surgery. In particular, patients undergoing laparoscopic resections for benign disease and without other risk factors have such a low VTE risk that prolonged prophylaxis is probably not warranted.
authors.affiliation: Royal Brisbane Hospital, Herston, Brisbane, Australia. pmverheijen@gmail.com
authors.forename: Paulus Menno
authors.initials: PM
authors.lastname: Verheijen
authors.forename: Andrew R L
authors.initials: AR
authors.lastname: Stevenson
authors.forename: Russel W
authors.initials: RW
authors.lastname: Stitz
authors.forename: David A
authors.initials: DA
authors.lastname: Clark
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Clark
authors.forename: John W
authors.initials: JW
authors.lastname: Lumley
mesh_terms: D003107:Colorectal Surgery / Q000009:adverse effects*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology; D013923:Thromboembolism / Q000209:etiology* / Q000517:prevention & control*