title: Dogs mean arterial pressure and heart rate responses during high propofol plasma concentrations estimated by a pharmacokinetic model.
abstract: Propofol total intravenous anesthesia should provide stability of the cardiovascular system. In this study, mean arterial pressure and heart rate were evaluated in eight healthy dogs anesthetized with increasing rates of propofol. The cerebral state index (CSI) was studied as an additional parameter. Although the estimated propofol plasma concentration reached a maximal value of 15.3 μg ml(-1), no hypotension or bradycardia were observed. Exploration of each animal's data revealed high inter-individual variability regarding mean arterial pressure and heart rate. Considering the logarithmic of the concentration, a moderate depressant effect of propofol on mean arterial pressure was revealed in five dogs but the effect was not followed on heart rate.
authors.affiliation: Departamento de Ciências Veterinárias, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal. aurasilva@utad.pt
authors.forename: Aura
authors.initials: A
authors.lastname: Silva
authors.forename: Lénio M
authors.initials: LM
authors.lastname: Ribeiro
authors.forename: Nadja
authors.initials: N
authors.lastname: Bressan
authors.forename: Pedro
authors.initials: P
authors.lastname: Oliveira
authors.forename: David A
authors.initials: DA
authors.lastname: Ferreira
authors.forename: Luís M
authors.initials: LM
authors.lastname: Antunes
mesh_terms: D000771:Anesthesia, Intravenous / Q000379:methods* / Q000662:veterinary; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D004569:Electroencephalography / Q000662:veterinary; D006339:Heart Rate; D008297:Male; D008954:Models, Biological; D016343:Monitoring, Intraoperative / Q000379:methods* / Q000662:veterinary; D015742:Propofol / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol