title: Weight changes in subthalamic nucleus vs globus pallidus internus deep brain stimulation: results from the COMPARE Parkinson disease deep brain stimulation cohort.
abstract: BACKGROUND
  Parkinson's patients, on average, gain weight after deep brain stimulation (DBS).
  
  
  OBJECTIVE
  To determine potential differences in weight gain when comparing the subthalamic nucleus and the globus pallidus internus target.
  
  
  METHODS
  A retrospective analysis was performed on the prospective, randomized cohort of National Institutes of Health COMPARE trial DBS patients who received unilateral subthalamic nucleus or globus pallidus internus DBS. Baseline weights were recorded before DBS surgery and at 6, 12, and 18 months postoperatively. Relationships between weight change and changes in Beck Depression Inventory score, Unified Parkinson's Disease Rating Scale (UPDRS) motor score (part III) (also the dyskinesia duration and disability subscores from UPDRS IV), and Hoehn-Yahr stage were determined via Spearman's rank-order correlation coefficients. Regression analyses were performed to investigate the effects of potential factors on weight change over time.
  
  
  RESULTS
  Patients in the COMPARE DBS cohort gained a significant amount of weight, a mean of 4.86 lb (standard deviation = 8.73) (P = .001), but there was no significant difference between subthalamic nucleus and globus pallidus internus targets (weight gain of 4.29 ± 6.79 and 5.38 ± 10.32 lb, respectively; P = .68). Weight gain did not correlate with Beck Depression Inventory score change, UPDRS motor score, dyskinesia duration, dyskinesia disability change, or the Hoehn-Yahr stage (P = .62, .21, and .31, respectively). No specific variable was associated with weight gain, and there were no differences in binge eating post-surgery in either target.
  
  
  CONCLUSIONS
  There were significant changes in weight over time after DBS therapy. However, neither Beck Depression Inventory score change nor UPDRS score change or dyskinesia was correlated with weight gain. No significant factor was associated with the weight change.
authors.affiliation: Department of Neurology, University of Florida Movement Disorders Center McKnight Brain Institute, Gainesville, Florida 32611, USA.
authors.forename: Maren C
authors.initials: MC
authors.lastname: Locke
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Wu
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Foote
authors.forename: Marco
authors.initials: M
authors.lastname: Sassi
authors.forename: Charles E
authors.initials: CE
authors.lastname: Jacobson
authors.forename: Ramon L
authors.initials: RL
authors.lastname: Rodriguez
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Fernandez
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
mesh_terms: D015331:Cohort Studies; D046690:Deep Brain Stimulation / Q000009:adverse effects* / Q000379:methods; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D012189:Retrospective Studies; D020531:Subthalamic Nucleus / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology*