title: Angiotensin II: a candidate for an aldosterone-independent mediator of potassium preservation during volume depletion.
abstract: Two different stimulators of aldosterone secretion, high-potassium diet and low-sodium diet, have disparate effects on potassium secretion in the distal nephron. The mechanism by which the kidney preserves potassium in the face of a high-aldosterone, volume-depleted state has engendered much thought. Yue et al. now propose that angiotensin II inhibits the renal outer medullary potassium channel (ROMK1) through stimulation of the protein tyrosine kinase c-Src, perhaps acting as a signal to differentiate volume depletion from a high-potassium diet.
authors.affiliation: Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA. robert.hoover@emory.edu
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hoover
mesh_terms: D000450:Aldosterone / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D000081247:CSK Tyrosine-Protein Kinase; D004039:Diet, Sodium-Restricted; D006801:Humans; D020896:Hypovolemia / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying; D017419:Potassium, Dietary / Q000008:administration & dosage; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D019061:src-Family Kinases
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D017419:Potassium, Dietary; D000804:Angiotensin II; D000450:Aldosterone; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D019061:src-Family Kinases; C000631346:CSK protein, human; D011188:Potassium