title: Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas.
abstract: The synthesis and biological activity of 1,3-benzenedicarbonyl dithioureas are described. Bioassay results indicated that these compounds exhibited cytotoxicity against various cancer cells. For example, compounds 4a showed the best inhibition activities against KB and CNE2 with IC(50) 10.72 and 9.91 μM, respectively.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, and College of Chemistry, Central China Normal University, Wuhan 430079, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.forename: Yongju
authors.initials: Y
authors.lastname: Liang
authors.forename: Le
authors.initials: L
authors.lastname: Chen
authors.forename: Liwu
authors.initials: L
authors.lastname: Fu
authors.forename: Haiqin
authors.initials: H
authors.lastname: Wang
authors.forename: Hongwu
authors.initials: H
authors.lastname: He
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D006801:Humans; D010795:Phthalic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D010795:Phthalic Acids; D013890:Thiourea