title: Blood transfusion usage among adults with sickle cell disease - a single institution experience over ten years.
abstract: Transfusion of red blood cells is a major therapeutic option in sickle cell disease (SCD). There is strong evidence for its efficacy, particularly in primary and secondary stroke prevention in children, however, its use in other areas remains controversial. This study assessed the patterns of transfusion in the adult cohort attending King's College Hospital over a 10-year period, from 2000 to 2009. Total blood usage has increased significantly (P = 0·006) during this time, with 78% of the blood received by only 6% of the patients. The increase is explained by increased automated red cell exchange and increased usage for planned and acute transfusions for sickle-related complications.
authors.affiliation: Molecular Haematology, Division of Gene and Cell Based Therapy, King's College London School of Medicine, Denmark Hill, London, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Drasar
authors.forename: Norris
authors.initials: N
authors.lastname: Igbineweka
authors.forename: Nisha
authors.initials: N
authors.lastname: Vasavda
authors.forename: Matthew
authors.initials: M
authors.lastname: Free
authors.forename: Moji
authors.initials: M
authors.lastname: Awogbade
authors.forename: Marlene
authors.initials: M
authors.lastname: Allman
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Mijovic
authors.forename: Swee Lay
authors.initials: SL
authors.lastname: Thein
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D001803:Blood Transfusion / Q000379:methods / Q000706:statistics & numerical data* / Q000639:trends; D005260:Female; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data* / Q000639:trends; D012189:Retrospective Studies; D055815:Young Adult