title: Polyacrylate adsorbents for the selective adsorption of cholesterol-rich lipoproteins from plasma or blood.
abstract: Polyacrylate (PAA) adsorbents selectively bind low density lipoproteins (LDL) from human plasma and blood, whereas very low density lipoproteins (VLDL) are only minimally adsorbed. The adsorption of cholesterol-rich lipoproteins to PAA adsorbents is related to the molecular weight (mw) of the polyanion ligand. Ca(++) and Mg(++) inhibit the binding of LDL to PAA adsorbents. The chemical composition of the organic hardgels of the adsorbents does not have an influence on adsorption. The selective adsorption of LDL to PAA adsorbents can be explained to result from their low negative surface charge density and the specific colloid-chemical properties of the surface-bound PAA, which do not prevent LDL from binding to charge-like domains of the ligand. By contrast, VLDL and high density lipoproteins (HDL) are repelled from the adsorbents due to their higher negative surface charge density.
authors.affiliation: Heinrich Heine University, Institute for Laboratory Medicine, Düsseldorf, Germany. heuck@med.uni-duesseldorf.de
authors.forename: Claus-Chr
authors.initials: CC
authors.lastname: Heuck
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D000327:Adsorption / Q000187:drug effects; D000838:Anions / Q000737:chemistry / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D005027:Ethylene Oxide / Q000302:isolation & purification; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry*; D008274:Magnesium / Q000494:pharmacology; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D000838:Anions; D008077:Lipoproteins, LDL; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; C006903:carbopol 940; D008274:Magnesium; D005027:Ethylene Oxide; D002118:Calcium