title: Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors.
abstract: The interaction of autotaxin with its substrates leads to the production of lysophosphatidic acids (LPA), bioactive lipids with an emerging prominent role in inflammation and cancer. Two papers in this issue tell the previously unknown story of autotaxin, from substrate discrimination to highly efficient local delivery of LPA to target receptors.
authors.affiliation: Department of Systems Biology, Kleberg Center for Molecular Markers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. atabchy@mdanderson.org
authors.forename: Adel
authors.initials: A
authors.lastname: Tabchy
authors.forename: Gabor
authors.initials: G
authors.lastname: Tigyi
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Mills
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D016023:Integrins / Q000378:metabolism; D008246:Lysophospholipids / Q000378:metabolism*; D051379:Mice; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism; D043264:Phosphodiesterase I / Q000737:chemistry / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry / Q000378:metabolism; D011755:Pyrophosphatases / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism*; D013379:Substrate Specificity; D000099189:Lysophospholipase D
chemical_list: D016023:Integrins; D008246:Lysophospholipids; D009097:Multienzyme Complexes; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; D049368:Receptors, Lysophosphatidic Acid; D000099189:Lysophospholipase D