title: Hippocampal deletion of BDNF gene attenuates gamma oscillations in area CA1 by up-regulating 5-HT3 receptor.
abstract: BACKGROUND
  Pyramidal neurons in the hippocampal area CA3 express high levels of BDNF, but how this BDNF contributes to oscillatory properties of hippocampus is unknown.
  
  
  RESULTS
  Here we examined carbachol-induced gamma oscillations in hippocampal slices lacking BDNF gene in the area CA3. The power of oscillations was reduced in the hippocampal area CA1, which coincided with increases in the expression and activity of 5-HT3 receptor. Pharmacological block of this receptor partially restored power of gamma oscillations in slices from KO mice, but had no effect in slices from WT mice.
  
  
  CONCLUSIONS
  These data suggest that BDNF facilitates gamma oscillations in the hippocampus by attenuating signaling through 5-HT3 receptor. Thus, BDNF modulates hippocampal oscillations through serotonergic system.
authors.affiliation: Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Alexei
authors.initials: A
authors.lastname: Morozov
mesh_terms: D000818:Animals; D058256:Brain Waves / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics* / Q000502:physiology; D056547:CA1 Region, Hippocampal / Q000378:metabolism* / Q000502:physiology; D002217:Carbachol / Q000494:pharmacology; D017353:Gene Deletion; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D044406:Receptors, Serotonin, 5-HT3 / Q000096:biosynthesis*; D015854:Up-Regulation / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D044406:Receptors, Serotonin, 5-HT3; D002217:Carbachol