title: Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model.
abstract: Stroke results in the disruption of tissue architecture and is the third leading cause of death in the United States. Transplanting scaffolds containing stem cells into the injured areas of the brain has been proposed as a treatment strategy, and carbon nanotubes show promise in this regard, with positive outcomes when used as scaffolds in neural cells and brain tissues. Here, we show that pretreating rats with amine-modified single-walled carbon nanotubes can protect neurons and enhance the recovery of behavioural functions in rats with induced stroke. Treated rats showed less tissue damage than controls and took longer to fall from a rotating rod, suggesting better motor functions after injury. Low levels of apoptotic, angiogenic and inflammation markers indicated that amine-modified single-walled carbon nanotubes protected the brains of treated rats from ischaemic injury.
authors.affiliation: Department of Anatomy and Cell Biology, College of Medicine, Chung Ang University, Seoul, 156-756, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Anatomy and Cell Biology, College of Medicine, Chung Ang University, Seoul, 156-756, Korea.
authors.forename: Jiae
authors.initials: J
authors.lastname: Park
authors.affiliation: School of Advanced Materials Science and Engineering, SKKU Advanced Institute of Nanotechnology and Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, Korea.
authors.forename: Ok Ja
authors.initials: OJ
authors.lastname: Yoon
authors.affiliation: School of Advanced Materials Science and Engineering, SKKU Advanced Institute of Nanotechnology and Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Anatomy and Cell Biology, College of Medicine, Chung Ang University, Seoul, 156-756, Korea.
authors.forename: Do Yeon
authors.initials: DY
authors.lastname: Lee
authors.affiliation: Department of Anatomy and Cell Biology, College of Medicine, Chung Ang University, Seoul, 156-756, Korea.
authors.forename: Do Hee
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Anatomy and Cell Biology, College of Medicine, Chung Ang University, Seoul, 156-756, Korea.
authors.forename: Won Bok
authors.initials: WB
authors.lastname: Lee
authors.affiliation: School of Advanced Materials Science and Engineering, SKKU Advanced Institute of Nanotechnology and Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, Korea.
authors.forename: Nae-Eung
authors.initials: NE
authors.lastname: Lee
authors.affiliation: Renal Division, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Joseph V
authors.initials: JV
authors.lastname: Bonventre
authors.affiliation: Department of Anatomy and Cell Biology, College of Medicine, Chung Ang University, Seoul, 156-756, Korea.
authors.forename: Sung Su
authors.initials: SS
authors.lastname: Kim
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D004195:Disease Models, Animal; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D053583:Interleukin-1beta / Q000378:metabolism; D009043:Motor Activity; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000473:pathology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000588:Amines; D015820:Cadherins; D005904:Glial Fibrillary Acidic Protein; D053583:Interleukin-1beta; D037742:Nanotubes, Carbon; D014409:Tumor Necrosis Factor-alpha; D051057:Proto-Oncogene Proteins c-akt