title: [Animal models for bone and joint disease. The genetically-modified mice as a tool for osteoporosis research].
abstract: Recent advances of molecular genetics made it possible to generate genetically-modified mice. Furthermore, the discovery and application of Cre-loxP recombination system into mouse genetics led to study the function of a gene in a tissue-specific manner. Analyses of these mutant mice advanced our understanding of the molecular physiology and pathophisiology of skeletal tissue.
authors.affiliation: Section of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Keio University.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ochi
authors.forename: Shu
authors.initials: S
authors.lastname: Takeda
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D004195:Disease Models, Animal; D015195:Drug Design; D026502:LDL-Receptor Related Proteins / Q000502:physiology; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010024:Osteoporosis / Q000235:genetics / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D051153:Wnt Proteins / Q000502:physiology
chemical_list: D026502:LDL-Receptor Related Proteins; D060492:Low Density Lipoprotein Receptor-Related Protein-5; C555483:Lrp5 protein, mouse; D011506:Proteins; D014157:Transcription Factors; D051153:Wnt Proteins