title: Impact of vitamin D in the treatment of tuberculosis.
abstract: Tuberculosis (TB) is a major global health problem and often coincides with nutritional deficiency. In fact, vitamin D deficiency has been reported among TB patients, and vitamin D receptor polymorphisms are associated with susceptibility to Mycobacterium tuberculosis. High doses of vitamin D were widely used to treat TB patients in the preantibiotic era. This approach was successful: vitamin D can suppress intracellular growth of M tuberculosis in vitro. Vitamin D also induced the expression of cathelicidin, which is involved in the first line of defense in TB patients. Thus, vitamin D may have a role in TB treatment, and further investigation is needed.
authors.affiliation: Vietnamese American Research Foundation, Westminster, California, USA. Lng2687765@aol.com
authors.forename: Khanh vinh quoc
authors.initials: Kv
authors.lastname: Luong
authors.forename: Lan Thi Hoang
authors.initials: LT
authors.lastname: Nguyen
mesh_terms: D002117:Calcitriol / Q000494:pharmacology / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy* / Q000235:genetics*; D014807:Vitamin D / Q000494:pharmacology* / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000150:complications*
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D; D002117:Calcitriol