title: [Adverse cutaneous reactions to drugs among hospitalized patients: a one year surveillance].
abstract: BACKGROUND
  Adverse cutaneous reactions to Drugs (CDRs) are of particular interest among all adverse Drug reactions (ADR) due to their frequency, potential severity and because of the importance of an early diagnosis. Antimicrobial agents, anticonvulsants and non-steroidal anti-inflammatory Drugs are the Drugs associated to the highest risk of CDRs.
  
  
  OBJECTIVE
  To assess CDRs in hospitalized patients and identify the Drugs involved.
  
  
  METHODS
  All patients hospitalized in the Hospital de Clínicas in Montevideo, Uruguay, with suspected CDRs, detected during one year, were included in this prospective study. The imputability was established using the Karch and Lasagna algorithm modified by Naranjo. We analyzed age, gender, Drugs involved, causal disease, severity, latency and evolution.
  
  
  RESULTS
  Seventeen patients, aged 17 to 85 years (15 females) with CDRs were identifed. Twelve had morbilliform exanthemas, four had reactions with eosinophilia and systemic symptoms and one had a Stevens Johnson syndrome. The Drugs involved were antimicrobials in nine cases, hypouricemic agents in four cases, anticonvulsants in three cases and aspartic insulin in one. Twelve patients had a life threatening reaction and one required admission to the intensive care unit. No deaths occurred.
  
  
  CONCLUSIONS
  CDRs were more common in women and most of them were caused by antimicrobial agents.
authors.affiliation: Departamento Clínico de Medicina, Hospital de Clínicas, Montevideo, Uruguay. adanza@hc.edu.uy
authors.forename: Alvaro
authors.initials: A
authors.lastname: Danza
authors.forename: Maynés
authors.initials: M
authors.lastname: López
authors.forename: Magdalena
authors.initials: M
authors.lastname: Vola
authors.forename: Alfredo
authors.initials: A
authors.lastname: Alvarez-Rocha
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects*; D003875:Drug Eruptions / Q000145:classification / Q000209:etiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants