title: Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells.
abstract: A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC(50) value of 10.4 and 3.8 μM, respectively.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
authors.forename: Seong Su
authors.initials: SS
authors.lastname: Hong
authors.forename: Seon A
authors.initials: SA
authors.lastname: Lee
authors.forename: Nahyun
authors.initials: N
authors.lastname: Kim
authors.forename: Ji Sang
authors.initials: JS
authors.lastname: Hwang
authors.forename: Xiang Hua
authors.initials: XH
authors.lastname: Han
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Jung
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D037602:Isodon / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000378:metabolism*; D035261:Plant Components, Aerial / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D004224:Diterpenes; D008070:Lipopolysaccharides; D011760:Pyrrolidinones; C558295:excisusin F; C558296:inflexarabdonin E; D009569:Nitric Oxide