title: Glomerular filtration rate and prevalence of chronic kidney disease in Wilms' tumour survivors.
abstract: Glomerular filtration rate (GFR) was evaluated in 32 Wilms' tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and the Filler formula. Kidney damage was established by beta-2-microglobulin (B-2-M) and albumin urine excretion, urine sediment and ultrasound examination. Blood pressure was measured. No differences were found between the mean GFR in 99 Tc-DTPA and the new Schwartz equation for CKD (91.8 ± 11.3 vs. 94.3 ± 10.2 ml/min/1.73 m(2) [p = 0.55] respectively). No differences were observed between estimated glomerular filtration rate (eGFR) using the Schwartz formula and the Filler formula either (122.3 ± 19.9 vs. 129.8 ± 23.9 ml/min/1.73 m(2) [p = 0.28] respectively). Increased urine albumin and B-2-M excretion, which are signs of kidney damage, were found in 7 (22%) and 3 (9.4%) WTs respectively. Ultrasound signs of kidney damage were found in 14 patients (43%). Five patients (15.6%) had more than one sign of kidney damage. Eighteen individuals (56.25%) had CKD stage I (10 with signs of kidney damage; 8 without). Fourteen individuals (43.75%) had CKD stage II (6 with signs of kidney damage; 8 without). The new Schwartz equation for CKD better estimated GFR in comparison to the Schwartz formula and the Filler formula. Furthermore, the WT survivors had signs of kidney damage despite the fact that GFR was not decreased below 90 ml/min/1.73 m(2) with 99 Tc- DTPA.
authors.affiliation: Department of Paediatrics, Medical University of Gdansk, Gdansk, Poland. jstefanowicz@gumed.edu.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefanowicz
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kosiak
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Romanowicz
authors.forename: Radosław
authors.initials: R
authors.lastname: Owczuk
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Adamkiewicz-Drożyńska
authors.forename: Anna
authors.initials: A
authors.lastname: Balcerska
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000628:therapy; D008297:Male; D015995:Prevalence; D011878:Radiotherapy / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D017741:Survivors / Q000706:statistics & numerical data; D014463:Ultrasonography; D009396:Wilms Tumor / Q000150:complications* / Q000628:therapy; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents