title: Elevated serum levels of CCL17 correlate with increased peripheral blood platelet count in patients with active tuberculosis in China.
abstract: The serum levels of Th2 markers, including CCL17 (thymus and activation-regulated chemokine [TARC]), CCL22 (macrophage-derived chemokine [MDC]), and soluble CD30, were measured in 101 HIV-negative tuberculosis patients, 103 healthy community controls, and 18 tuberculosis patients in recovery. The levels of CCL17/TARC (249.8 ± 19.91 versus 143.9 ± 10.54, P < 0.0001) and sCD30 (7.78 ± 0.44 versus 4.93 ± 0.23, P < 0.0001) were significantly higher in patients with active tuberculosis than in controls; however, the CCL22/MDC serum level had no statistical difference between the groups (579.9 ± 16.42 versus 556.5 ± 15.29, P = 0.298). The counts of platelet and eosinophil in the peripheral blood of patients with active tuberculosis are significantly increased as well (289.4 ± 8.14 versus 248.3 ± 5.34 [P < 0.0001] and 165.1 ± 14.33 versus 102.5 ± 10.72 [P = 0.0005], respectively), and the platelet counts were positively correlated with serum TARC levels (Pearson r = 0.456, P < 0.0001), which indicates a new source of Th2 bias showing in active TB patients.
authors.affiliation: Shanghai Key Laboratory of Tuberculosis, Tuberculosis Diagnosis and Treatment Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai 200433, China. feng_yonghong@hotmail.com
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Feng
authors.forename: Hongyun
authors.initials: H
authors.lastname: Yin
authors.forename: Guangliang
authors.initials: G
authors.lastname: Mai
authors.forename: Ling
authors.initials: L
authors.lastname: Mao
authors.forename: Jun
authors.initials: J
authors.lastname: Yue
authors.forename: Heping
authors.initials: H
authors.lastname: Xiao
authors.forename: Zhongyi
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D054414:Chemokine CCL17 / Q000097:blood*; D054422:Chemokine CCL22 / Q000097:blood; D002681:China; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D044967:Serum / Q000737:chemistry; D014376:Tuberculosis / Q000175:diagnosis* / Q000473:pathology*; D055815:Young Adult
chemical_list: C106230:CCL17 protein, human; C515482:CCL22 protein, human; D054414:Chemokine CCL17; D054422:Chemokine CCL22; D017730:Ki-1 Antigen