title: Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm.
abstract: BACKGROUND
  Methamphetamine (MA) is an addictive psychostimulant associated with neurocognitive impairment, including inhibitory deficits characterized by a reduced ability to control responses to stimuli. While various domains of inhibition such as exaggerated novelty seeking and perseveration have been assessed in rodents by quantifying activity in open-field tests, similar models have not been utilized in human substance abusers. We recently developed a cross-species translational human open-field paradigm, the human behavior pattern monitor (hBPM), consisting of an unfamiliar room containing novel and engaging objects. Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions.
  
  
  OBJECTIVE
  In the current study, we examined the effect of MA dependence on inhibitory deficits using this paradigm. hBPM activity and object interactions were quantified in 16 abstinent MA-dependent individuals and 18 matched drug-free comparison subjects. The Wisconsin card sorting task (WCST) and the positive and negative syndrome scale (PANSS) were administered to assess executive function and psychopathology.
  
  
  RESULTS
  MA-dependent participants exhibited a significant increase in total object interactions, time spent with objects, and perseverative object interactions relative to comparison subjects. Greater object interaction was associated with impaired performance on the WCST, higher PANSS scores, and more frequent MA use in the past year.
  
  
  CONCLUSIONS
  Abstinent MA-dependent individuals exhibited impaired inhibition in the hBPM, displaying increased interaction with novel stimuli. Utilization of this measure may enable assessment of inhibitory deficits relevant to drug-seeking behavior and facilitate development of intervention methods to reduce high-risk conduct in this population.
authors.affiliation: Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. blhenry@ucsd.edu
authors.forename: Brook L
authors.initials: BL
authors.lastname: Henry
authors.forename: Arpi
authors.initials: A
authors.lastname: Minassian
authors.forename: Mandy
authors.initials: M
authors.lastname: van Rhenen
authors.forename: Jared W
authors.initials: JW
authors.lastname: Young
authors.forename: Mark A
authors.initials: MA
authors.lastname: Geyer
authors.forename: William
authors.initials: W
authors.lastname: Perry
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000523:psychology*; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D009483:Neuropsychological Tests
chemical_list: D008694:Methamphetamine