title: High grade CIN diagnosis by combined visual inspection with Lugol's iodine and cytology in symptomatic women.
abstract: OBJECTIVE
  To investigate the diagnostic performance of combining the visual inspection with Lugol's iodine (VILI) and cytology screening to detect high-grade cervical intraepithelial neoplasia (CIN-2 or CIN-3) in symptomatic women, using histological examination as the standard reference test.
  
  
  METHODS
  Cross-sectional referral study utilizing secondary data from 538 medical records from a clinic specialized in cervical pathology in Brazil.
  
  
  RESULTS
  Although the sensitivity reached 96.8%, the specificity was only 8.1%, with positive predictive value of 18.3% and negative predictive value of 92.3%.
  
  
  CONCLUSIONS
  The combination of both tests proved to be highly sensitive, leading to a large decrease in the false negative results. This was achieved, however, at the cost of an excess in the rate of false positive results, thus making the combination unviable for screening in symptomatic women.
authors.affiliation: Department of Obstetrics and Gynecology, Federal University of Santa Catarina, Florianópolis, Brazil.
authors.forename: Evandro
authors.initials: E
authors.lastname: Russo
authors.forename: Emil
authors.initials: E
authors.lastname: Kupek
authors.forename: Rita Maria
authors.initials: RM
authors.lastname: Zanine
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007454:Iodides; D008499:Medical Records; D008875:Middle Aged; D009367:Neoplasm Staging; D012307:Risk Factors; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology
chemical_list: D004396:Coloring Agents; D007454:Iodides; C010389:Lugol's solution