title: Au nanowire-on-film SERRS sensor for ultrasensitive Hg2+ detection.
abstract: We report an ultrasensitive and selective single nanowire-on-film (SNOF) surface-enhanced resonance Raman scattering (SERRS) sensor for Hg(2+) detection based on structure-switching double stranded DNAs (dsDNAs). Binding of Hg(2+) induces conformational changes of the dsDNAs and let a Raman reporter get close to the SNOF structure, thereby turning on SERRS signal. The well-defined SNOF structure provides a detection limit of 100 pM with improved accuracy in Hg(2+) detection. This sensor is stable over a considerable amount of time and reusable after simple treatment. Since this SNOF sensor is composed of a single Au NW on a film, development of a multiplex sensor would be possible by employing NWs modified by multiple kinds of aptamers.
authors.affiliation: Department of Chemistry, KAIST, Daejeon 305-701, Korea.
authors.forename: Taejoon
authors.initials: T
authors.lastname: Kang
authors.forename: Seung Min
authors.initials: SM
authors.lastname: Yoo
authors.forename: Ilsun
authors.initials: I
authors.lastname: Yoon
authors.forename: Sangyeop
authors.initials: S
authors.lastname: Lee
authors.forename: Jaebum
authors.initials: J
authors.lastname: Choo
authors.forename: Sang Yup
authors.initials: SY
authors.lastname: Lee
authors.forename: Bongsoo
authors.initials: B
authors.lastname: Kim
mesh_terms: D015374:Biosensing Techniques; D059018:DNA Contamination; D006046:Gold / Q000032:analysis* / Q000737:chemistry*; D008628:Mercury / Q000032:analysis* / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000032:analysis* / Q000737:chemistry*; D053770:Nanowires / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
chemical_list: D006046:Gold; D008628:Mercury