title: [Maternal-fetal chikungunya infection associated with Bernard-Soulier syndrome].
abstract: Neonatal thrombocytopenia may stem from several origins. A newborn was hospitalized on the 3rd day of life with thrombocytopenia likely due to maternofetal autoimmune thrombocytopenia. Two days later, he displayed a chikungunya virus infection, during a severe epidemic on Reunion Island. The characterization of human platelet antigen (HPA) in the parents showed incompatibility in the HPA-3 system; however, no detectable antiHPA-3a antibody was found in the mother's serum. The persistence of moderate thrombocytopenia led to the diagnosis, using flow cytometry, of Bernard-Soulier syndrome (BSS), with no detectable GPIbIX. This case shows that neonatal inherited thrombocytopenia may be difficult to characterize, especially when it is associated with an acquired cause.
authors.affiliation: Service de réanimation néonatale et pédiatrique, groupe hospitalier Sud-Réunion, 97410 Saint-Pierre, Réunion. boumahni@wanadoo.fr
authors.forename: B
authors.initials: B
authors.lastname: Boumahni
authors.forename: C
authors.initials: C
authors.lastname: Kaplan
authors.forename: A
authors.initials: A
authors.lastname: Clabé
authors.forename: H
authors.initials: H
authors.lastname: Randrianaivo
authors.forename: F
authors.initials: F
authors.lastname: Lanza
mesh_terms: D018354:Alphavirus Infections / Q000175:diagnosis; D001606:Bernard-Soulier Syndrome / Q000175:diagnosis*; D065632:Chikungunya Fever; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis; D013921:Thrombocytopenia / Q000209:etiology*