title: Enantioselective hydrocyanation of aldehydes catalyzed by [Li{Ru(phgly)2(binap)}]X (X = Cl, Br).
abstract: Novel bimetallic complexes [Li{Ru[(S)-phgly](2)[(S)-binap]}]X (X = Cl, Br) are readily synthesized by mixing Ru[(S)-phgly](2)[(S)-binap] and LiX. A single-crystal X-ray analysis reveals the structure. These bimetallic complexes efficiently catalyze asymmetric hydrocyanation of aldehydes with a substrate-to-catalyst molar ratio of 500-2000 at -78 to -60 °C. A range of aromatic, heteroaromatic, and α,β-unsaturated aldehydes as well as a tert-alkyl aldehyde is converted to the cyanohydrins in high enantiomeric excess (up to 99%).
authors.affiliation: Division of Chemical Process Engineering, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido, Japan.
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Kurono
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Mikio
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohkuma
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D006846:Hydrocarbons, Halogenated; D009570:Nitriles; D009942:Organometallic Compounds; C430593:cyanohydrin; D012428:Ruthenium