title: Pd-catalyzed amination as an alternative to nucleophilic aromatic substitution for the synthesis of N-alkyltacrines and analogues.
abstract: A reliable Pd-catalyzed amination protocol is described for the synthesis of N-alkyltacrines and analogues. The Josiphos ligand CyPFtBu was found to provide optimum yields: 16 examples are given. Compared to the typical high-temperature nucleophilic aromatic substitution (NAS) routes, Pd-catalyzed aminations proceed at significantly lower reaction temperatures, and enable the synthesis of otherwise inaccessible products.
authors.affiliation: Department of Chemistry, Virginia Tech, Blacksburg, VA, 24060.
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.forename: Jimit
authors.initials: J
authors.lastname: Mehta
authors.forename: Larry D
authors.initials: LD
authors.lastname: Williams
authors.forename: Paul R
authors.initials: PR
authors.lastname: Carlier