title: Toxicity evaluation of sappan wood extract in rats.
abstract: BACKGROUND
  The heartwood of Caesalpinia sappan L. or sappan wood has long been used in folk medicines to treat tuberculosis, diarrhea, dysentery, skin infections and anemia.
  
  
  OBJECTIVE
  To study the acute and subacute toxicities of sappan wood extract in rats.
  
  
  METHODS
  For studying acute toxicity, a single oral dose of 5000 mg/kg of sappan wood was administered to rats. Subacute toxicity was studied by the daily oral administration of the extract at the doses of 250, 500 and 1000 mg/kg body weight for consecutive 30 days.
  
  
  RESULTS
  The extract of sappan wood (5000 mg/kg) showed no toxicity in terms of general behavior change, mortality, or change in gross appearance of internal organs. Subacute toxicity study showed no abnormalities in treatment groups as compared to the controls. Body and organ weights, hematological, blood chemical, necropsy, and histopathological parameter of all groups were similar.
  
  
  CONCLUSIONS
  Sappan wood extract did not produce any acute or subacute toxicity in both female and male rats.
authors.affiliation: Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rungsit Campus, Pathumthani, Thailand. seewaboon@gmail.com
authors.forename: Seeewaboon
authors.initials: S
authors.lastname: Sireeratawong
authors.forename: Pritsana
authors.initials: P
authors.lastname: Piyabhan
authors.forename: Tippaya
authors.initials: T
authors.lastname: Singhalak
authors.forename: Yuvadee
authors.initials: Y
authors.lastname: Wongkrajang
authors.forename: Rungravi
authors.initials: R
authors.lastname: Temsiririrkkul
authors.forename: Jakkapun
authors.initials: J
authors.lastname: Punsrirat
authors.forename: Nongluck
authors.initials: N
authors.lastname: Ruangwises
authors.forename: Sumarn
authors.initials: S
authors.lastname: Saraya
authors.forename: Nusiri
authors.initials: N
authors.lastname: Lerdvuthisopon
authors.forename: Kanjana
authors.initials: K
authors.lastname: Jaijoy
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D029911:Caesalpinia / Q000633:toxicity*; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute; D014934:Wood / Q000633:toxicity*