title: Activate Rac to rescue new vessels.
abstract: Vascular endothelial growth factor (VEGF) is a major driver of physiologic and pathologic vascularization, but VEGF therapies generally fail to sustainably revascularize ischemic tissues. In this issue of Blood, Hoang and coworkers demonstrate that Rac1 may be the missing ingredient for achieving this goal.
authors.affiliation: National Cancer Institute.
authors.forename: David D
authors.initials: DD
authors.lastname: Roberts