title: TIP60 as a potential marker for the malignancy of gastric cancer.
abstract: BACKGROUND
  Recently, it has been shown that the loss of the human histone acetyl transferase, TIP60, led to an accumulation of double-strand DNA breaks and has been linked to a growing number of cancer types.
  
  
  METHODS
  TIP60 expression levels were examined in 46 gastric cancer samples using a quantitative real-time polymerase chain reaction (QRT-PCR). Subsequently, clinicopathological data were correlated with the TIP60 expression score.
  
  
  RESULTS
  A down-regulation of the TIP60 gene was observed in 28 out of 46 (61%) specimens of primary gastric cancer. TIP60 down-regulation showed significant correlation with patient age (p=0.0224), depth of tumor invasion (p=0.0401) and lymph node metastasis (p=0.0481).
  
  
  CONCLUSIONS
  The down-regulation of TIP60 is important for the malignant pathway of gastric carcinogenesis.
authors.affiliation: Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Sakuraba
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shirahata
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Goto
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Saito
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Gaku
authors.initials: G
authors.lastname: Kigawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nemoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Hibi
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D051548:Histone Acetyltransferases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000556:secondary; D008207:Lymphatic Metastasis; D000074443:Lysine Acetyltransferase 5; D008297:Male; D010534:Peritoneal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000556:secondary; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5