title: [Anabolic/catabolic imbalance in chronic heart failure].
abstract: A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The T.O.S.CA. project aims at investigating the relationship between CHF and hormonal deficiency.
authors.affiliation: Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche,Universitc Federico II, Napoli, Italy. antonio.cittadini@unina.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Cittadini
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bossone
authors.forename: Alberto Maria
authors.initials: AM
authors.lastname: Marra
authors.forename: Michele
authors.initials: M
authors.lastname: Arcopinto
authors.forename: Emanuele
authors.initials: E
authors.lastname: Bobbio
authors.forename: Salvatore
authors.initials: S
authors.lastname: Longobardi
authors.forename: Carmine
authors.initials: C
authors.lastname: Cevara
authors.forename: Sara
authors.initials: S
authors.lastname: Di Michele
authors.forename: Luigi
authors.initials: L
authors.lastname: Saccà
mesh_terms: D002908:Chronic Disease; D006333:Heart Failure / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000209:etiology