title: The neurophysiology of hydrogen sulfide.
abstract: Hydrogen sulfide (H(2)S) has emerged as the third endogenous gaseous mediator in the central and peripheral nervous system. H(2)S is generated by three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). In the CNS, H(2)S, generated mainly by CBS in astrocytes and 3MST in neurons, appears to participate in cognition, memory, regulation of the cardiopulmonary functions and neuroprotection. In the peripheral nervous system, evidence suggests that H(2)S may be involved in autonomic control of the cardiopulmonary and gastrointestinal functions as well pain and inflammation.
authors.affiliation: Department of Physiology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Weifang
authors.initials: W
authors.lastname: Rong
authors.forename: Hideo
authors.initials: H
authors.lastname: Kimura
authors.forename: David
authors.initials: D
authors.lastname: Grundy
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D017933:Peripheral Nervous System / Q000502:physiology*; D013466:Sulfurtransferases / Q000378:metabolism
chemical_list: D013466:Sulfurtransferases; C021550:3-mercaptopyruvate sulphurtransferase; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide