title: Evaluation of optical density of bone defects filled with calcium phosphate cement and bioactive glass in rats.
abstract: OBJECTIVE
  To evaluate new bone formation, by the analysis of optical density, in rat femoral defects filled with calcium phosphate cement (CPC) and bioactive glass (BG).
  
  
  METHODS
  Twenty-one rats were divided into three groups, Group I (CPC), Group II (BG), and Group III (control), and assessed after 7, 15, and 30 days. Three bone cavities were made in the left femur and filled with CPC, BG, and no material (control). Digital images were obtained and the results were subjected to statistical analysis of variance (ANOVA), complemented by the Friedman and Kruskal-Wallis nonparametric tests, with a significance level of 5%.
  
  
  RESULTS
  Regarding optical density, Group I showed statistical values significantly higher than Group III and also higher, although not statistically significant, than Group II, in all observation periods. When Groups II and III were compared, Group II showed higher optical density values, without statistically significant differences, in all periods.
  
  
  CONCLUSIONS
  The biomaterials analyzed showed higher optical density in relation to the control group in all observation periods, calcium phosphate cement being the best option in the repair of bone defects, but without statistically significant differences in relation to bioactive glass.
authors.affiliation: Department of Oral and Maxillofacial Surgery, ULBRA, Canoas, RS, Brazil.
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Biancon Filho
authors.forename: Bruno Tochetto
authors.initials: BT
authors.lastname: Primo
authors.forename: Humberto Thomazi
authors.initials: HT
authors.lastname: Gassen
authors.forename: Vânia Regina Camargo
authors.initials: VR
authors.lastname: Fontanella
authors.forename: Aurelício Novaes
authors.initials: AN
authors.lastname: Silva
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D015519:Bone Density; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D005269:Femur / Q000000981:diagnostic imaging / Q000293:injuries*; D005898:Glass / Q000737:chemistry; D008297:Male; D011859:Radiography; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; C020243:calcium phosphate