title: Serological profiles of urate, paraoxonase-1, ferritin and lipid in Parkinson's disease: changes linked to disease progression.
abstract: BACKGROUND
  Oxidative stress plays a role in the pathogenesis of neuronal death. Serum levels of urate or lipid were associated with the incidence of Parkinson's disease (PD).
  
  
  OBJECTIVE
  We compared urate, paraoxonase-1 (PON1), iron, ferritin and lipid in sera of 119 PD patients and 120 healthy controls matched by age, sex and body mass index. We aimed to elucidate whether those serological data are correlated with disease progression.
  
  
  RESULTS
  Mean age (SD) of PD patients was 73.4 (8.7) years. Mean Yahr stage (SD) was 3.2 (0.9). Mean disease duration (SD) was 6.9 (5.1) years. Mean dose of L-DOPA (SD) was 355 (157) mg/day. As compared to controls, serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), urate and PON1 activity were significantly reduced, and serum ferritin levels were significantly increased in male and female PD patients. Serum urate levels and PON1 activities were inversely related, and serum ferritin levels were correlated with Yahr stage and PD duration in men and women. Serum levels of TC and LDL-C were inversely related to Yahr stage or PD duration in female patients.
  
  
  CONCLUSIONS
  Our studies indicated serological profiles of urate, PON1, ferritin, TC and LDL-C in PD patients. These serological changes were linked to PD progression. Metabolism of lipid, oxidant- and antioxidant-related substances may contribute to the pathogenesis and the progression of PD.
authors.affiliation: Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Ikeda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Tetsuhito
authors.initials: T
authors.lastname: Kiyozuka
authors.forename: Joe
authors.initials: J
authors.lastname: Aoyagi
authors.forename: Takehisa
authors.initials: T
authors.lastname: Hirayama
authors.forename: Riya
authors.initials: R
authors.lastname: Nagata
authors.forename: Hirono
authors.initials: H
authors.lastname: Ito
authors.forename: Konosuke
authors.initials: K
authors.lastname: Iwamoto
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Murata
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshii
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Kawabe
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood* / Q000503:physiopathology; D014527:Uric Acid / Q000097:blood*
chemical_list: D008055:Lipids; D014527:Uric Acid; D005293:Ferritins; D043303:Aryldialkylphosphatase