title: Three novel members of angucycline group from Streptomyces sp. N05WA963.
abstract: Three novel members of angucycline family named N05WA963A (1), B (2) and D (4), together with a new anthracycline named N05WA963C (3) were isolated from the culture broth of Streptomyces sp. N05WA963. The structures were elucidated on the basis of comprehensive spectral data analysis. All four compounds have shown antiproliferative effects on a panel of cancer cell lines such as SW620, K-562, MDA-MB-231, YES-4, T-98 and U251SP.
authors.affiliation: New Drug Research and Development Center, North China Pharmaceutical Group Corporation, National Microbial Medicine Engineering and Research Center, Hebei, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ren
authors.forename: Xinhua
authors.initials: X
authors.lastname: Lu
authors.forename: Aibing
authors.initials: A
authors.lastname: Ke
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Jie
authors.initials: J
authors.lastname: Lin
authors.forename: Weili
authors.initials: W
authors.lastname: Hao
authors.forename: Jingtong
authors.initials: J
authors.lastname: Zhu
authors.forename: Yuling
authors.initials: Y
authors.lastname: Fan
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Ding
authors.forename: Qin
authors.initials: Q
authors.lastname: Jiang
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
mesh_terms: D018943:Anthracyclines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013057:Spectrum Analysis; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D018943:Anthracyclines; D000880:Anthraquinones; D000970:Antineoplastic Agents; C558847:N05WA963A; C558845:N05WA963B; C558844:N05WA963C; C558846:N05WA963D