title: Extracts of Maqui ( Aristotelia chilensis ) and Murta ( Ugni molinae Turcz.): sources of antioxidant compounds and α-Glucosidase/α-Amylase inhibitors.
abstract: The objective of this work was to evaluate the antioxidant and antihemolytic activities of crude, aqueous, and organic-aqueous extracts of maqui ( Aristotelia chilensis ) and murta ( Ugni molinae Turcz.), together with their inhibiting effect on enzymes involved in the metabolism of carbohydrates. Radical scavenging activity, inhibition of linoleic acid oxidation in a micellar system, antihemolytic activity, and inhibition of α-amylases and α-glucosidases were analyzed. Crude extracts of maqui leaves and fruits were found to be important sources of polyphenolic compounds, showing 69.0 ± 0.9 and 45.7 ± 1.1 mg GAE/g dm, respectively. Polyphenols from maqui leaves were active as antioxidants and antihemolytic compounds (p < 0.05), showing a noncompetitive inhibiting effect on α-glucosidase. Flavan-3-ol polymers and glycosylated flavonols, such as quercetin glucoside and kaempferol glucoside, were tentatively identified in extracts. This preliminary observation provides the basis for further examination of the suitability of polyphenol-enriched extracts from maqui and murta as nutritional or medicinal supplements with potential human health benefits.
authors.affiliation: Center of Food Biotechnology and Bioseparations, BIOREN, and ‡Technology and Processes Unit, CGNA, Universidad de La Frontera , Casilla 54-D, Temuco, Chile.
authors.forename: Mónica
authors.initials: M
authors.lastname: Rubilar
authors.forename: Claudio
authors.initials: C
authors.lastname: Jara
authors.forename: Yohany
authors.initials: Y
authors.lastname: Poo
authors.forename: Francisca
authors.initials: F
authors.lastname: Acevedo
authors.forename: Cristian
authors.initials: C
authors.lastname: Gutierrez
authors.forename: Jorge
authors.initials: J
authors.lastname: Sineiro
authors.forename: Carolina
authors.initials: C
authors.lastname: Shene
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002677:Chile; D045467:Elaeocarpaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D013058:Mass Spectrometry; D027822:Myrtaceae / Q000737:chemistry*; D010636:Phenols / Q000032:analysis / Q000494:pharmacology; D010928:Placental Lactogen; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D059808:Polyphenols; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D010928:Placental Lactogen; D000516:alpha-Amylases