title: Implementation and workflow for PET monitoring of therapeutic ion irradiation: a comparison of in-beam, in-room, and off-line techniques.
abstract: An independent assessment of the dose delivery in ion therapy can be performed using positron emission tomography (PET). For that a distribution of positron emitters which appear as the result of interaction between ions of the therapeutic beam and the irradiated tissue is measured during or after the irradiation. Three concepts for PET monitoring implemented in various therapy facilities are considered in this paper. The in-beam PET concept relies on the PET measurement performed simultaneously to the irradiation by means of a PET scanner which is completely integrated into the irradiation site. The in-room PET concept allows measurement immediately after irradiation by a standalone PET scanner which is installed very close to the irradiation site. In the off-line PET scenario the measurement is performed by means of a standalone PET/CT scanner 10-30 min after the irradiation. These three concepts were evaluated according to image quality criteria, integration costs, and their influence onto the workflow of radiotherapy. In-beam PET showed the best performance. However, the integration costs were estimated as very high for this modality. Moreover, the performance of in-beam PET depends heavily on type and duty cycle of the accelerator. The in-room PET is proposed for planned therapy facilities as a good compromise between the quality of measured data and integration efforts. For facilities which are close to the nuclear medicine departments off-line PET can be suggested under several circumstances.
authors.affiliation: Technische Universität Dresden, Centre for Radiation Research in Oncology-Oncoray, Dresden, Germany. georgy.shakirin@philips.com
authors.forename: Georgy
authors.initials: G
authors.lastname: Shakirin
authors.forename: Henning
authors.initials: H
authors.lastname: Braess
authors.forename: Fine
authors.initials: F
authors.lastname: Fiedler
authors.forename: Daniela
authors.initials: D
authors.lastname: Kunath
authors.forename: Kristin
authors.initials: K
authors.lastname: Laube
authors.forename: Katia
authors.initials: K
authors.lastname: Parodi
authors.forename: Marlen
authors.initials: M
authors.lastname: Priegnitz
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Enghardt
mesh_terms: D006801:Humans; D007091:Image Processing, Computer-Assisted; D007477:Ions / Q000627:therapeutic use; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted / Q000295:instrumentation / Q000379:methods*
chemical_list: D007477:Ions