title: The development of cell line models of childhood brain tumours.
abstract: Childhood brain cancers have a significant impact on society. Currently, it is possible to make sophisticated diagnoses, but the treatments do not reflect patient differences and are out-dated. In order to develop better therapies and improve the outcome, we must first understand the underlying biology of brain cancer and how cells influence the disease process. For that purpose, several lines of brain cancer stem cells have been isolated, which have retained the characteristics of their original tissues. These in vitro human cell models are a much-needed addition to research on childhood brain cancers.
authors.affiliation: Human Development, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, UK. richard.grundy@nottingham.ac.uk
authors.forename: Richard
authors.initials: R
authors.lastname: Grundy
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*