title: Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population.
abstract: The present study was conducted to assess genetic associations for type 1 diabetes (T1D) reported in previous genome-wide association studies (GWAS). A total of 21 previously reported single-nucleotide polymorphisms (SNPs) were genotyped by TaqMan assays in 1434 Caucasian T1D patients and 1864 normal controls from Georgia. Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.
authors.affiliation: Center for Biotechnology and Genomic Medicine, and Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA.
authors.forename: M V Prasad Linga
authors.initials: MV
authors.lastname: Reddy
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Bode
authors.forename: J C
authors.initials: JC
authors.lastname: Reed
authors.forename: R D
authors.initials: RD
authors.lastname: Steed
authors.forename: S W
authors.initials: SW
authors.lastname: Anderson
authors.forename: L
authors.initials: L
authors.lastname: Steed
authors.forename: D
authors.initials: D
authors.lastname: Hopkins
authors.forename: J-X
authors.initials: JX
authors.lastname: She
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult