title: Application of speckle-tracking echocardiography in detecting coronary artery disease in patients with maintenance hemodialysis.
abstract: BACKGROUND
  Satisfactory and noninvasive diagnostic tools for coronary artery disease (CAD) are not available in hemodialysis patients. We aimed to elucidate a reliable tool to diagnose CAD in these patients.
  
  
  METHODS
  102 hemodialysis patients received 2D speckle-tracking echocardiography with left ventricular (LV) strain analysis and blood tests for cardiac troponin T, high-sensitive C-reactive protein, interleukin (IL)-6, and IL-18.
  
  
  RESULTS
  The levels of biomarkers did not differ between patients with and without CAD. The factors associated with CAD were decreased circumferential strain, decreased global longitudinal strain, and the number of LV segments with decreased longitudinal strain. Logistic regression analyses showed that the number of LV segments with decreased longitudinal strain, over 6 segments, was strongly associated with CAD in hemodialysis patients (OR 12.08, 95% CI 3.724-39.209).
  
  
  CONCLUSIONS
  The noninvasive modality of speckle-tracking echocardiography with strain analysis is efficient and objective for identifying CAD in hemodialysis patients.
authors.affiliation: Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC.
authors.forename: Yen-Wen
authors.initials: YW
authors.lastname: Liu
authors.forename: Chi-Ting
authors.initials: CT
authors.lastname: Su
authors.forename: Saprina P H
authors.initials: SP
authors.lastname: Wang
authors.forename: Chun-Shin
authors.initials: CS
authors.lastname: Yang
authors.forename: Jenq-Wen
authors.initials: JW
authors.lastname: Huang
authors.forename: Kuan-Yu
authors.initials: KY
authors.lastname: Hung
authors.forename: Jyh-Hong
authors.initials: JH
authors.lastname: Chen
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Tsai
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D020382:Interleukin-18 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D013624:Taiwan; D020107:Troponin T / Q000032:analysis; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D020382:Interleukin-18; D015850:Interleukin-6; D020107:Troponin T; D002097:C-Reactive Protein