title: Application of RNA interference in treating human diseases.
abstract: Gene silencing can occur either through repression of transcription, termed transcriptional gene silencing (TGS), or through translation repression andmRNA degradation, termed posttranscriptional gene silencing (PTGS). PTGS results from sequence-specific mRNA degradation in the cytoplasm without dramatic changes in transcription of corresponding gene in nucleus. Both TGS and PTGS are used to regulate endogenous genes. Interestingly, mechanisms for gene silencing also protect the genome from transposons and viruses. In this paper, we first review RNAi mechanism and then focus on some of its applications in biomedical research such as treatment for HIV, viral hepatitis, cardiovascular and cerebrovascular diseases, metabolic disease, neurodegenerative disorders and cancer.
authors.affiliation: Department of Biology, Tarbiat Moallem University, 31979-37551, Tehran, Iran. angaji@tmu.ac.ir
authors.forename: S Abdolhamid
authors.initials: SA
authors.lastname: Angaji
authors.forename: Sara Sadate
authors.initials: SS
authors.lastname: Hedayati
authors.forename: Reihane Hosein
authors.initials: RH
authors.lastname: Poor
authors.forename: Safoura
authors.initials: S
authors.lastname: Madani
authors.forename: Sanaz Samad
authors.initials: SS
authors.lastname: Poor
authors.forename: Samin
authors.initials: S
authors.lastname: Panahi
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000235:genetics; D020868:Gene Silencing; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics; D006526:Hepatitis C / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics; D034622:RNA Interference; D014777:Virus Diseases / Q000188:drug therapy* / Q000235:genetics; D014780:Viruses / Q000235:genetics