title: Assembly, disassembly and recycling: the dynamics of exon junction complexes.
abstract: Efficient gene expression requires that, during their lifetime, mRNAs associate with different sets of RNA binding proteins to form messenger ribonucleoprotein particles (mRNPs). The protein components of mRNPs are essential for the correct post-transcriptional function and regulation of mRNAs. mRNPs are constitutively remodeled during the maturation of the mRNA in the nucleus and downstream steps in the cytoplasm, and can also change depending on the cellular environment. Here we review the current understanding of the biochemical and structural aspects of a central mRNP component and regulator, the exon junction complex (EJC).
authors.affiliation: Max-Planck-Institute for Developmental Biology, Tübingen, Germany. fulvia.bono@tuebingen.mpg.de
authors.forename: Fulvia
authors.initials: F
authors.lastname: Bono
authors.forename: Niels H
authors.initials: NH
authors.lastname: Gehring
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D039601:Eukaryotic Initiation Factor-4A / Q000378:metabolism; D005091:Exons; D006801:Humans; D017434:Protein Structure, Tertiary; D012323:RNA Processing, Post-Transcriptional; D022821:RNA Splice Sites; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism*; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism; D017381:Spliceosomes / Q000378:metabolism
chemical_list: D022821:RNA Splice Sites; D012333:RNA, Messenger; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein; D000255:Adenosine Triphosphate; D039601:Eukaryotic Initiation Factor-4A