title: Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration.
abstract: BACKGROUND
  Achieving successful tissue regeneration following traditional therapeutic protocols, combining bone grafts and barrier membranes, may be challenging in certain clinical scenarios. A deeper understanding of periodontal and peri-implant wound healing and recent advances in the field of tissue engineering have provided clinicians with novel means to obtain predictable clinical outcomes. The use of growth factors such as recombinant human platelet-derived growth factor-BB (rhPDGF) with biocompatible matrices to promote tissue regeneration represents a promising approach in the disciplines of periodontology and implantology.
  
  
  METHODS
  This review covers the basic principles of bone and periodontal regeneration, and provides an overview of the biology of PDGF and its potential to predictably and reproducibly promote bone regeneration in regular clinical practice. The results of preclinical and clinical human studies evaluating the effectiveness of growth-factor-enhanced matrices are analyzed and discussed.
  
  
  CONCLUSIONS
  Current available evidence supports the use of rhPDGF-enhanced matrices to promote periodontal and peri-implant bone regeneration.
authors.affiliation: University of Michigan School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI 48109-1078, USA.
authors.forename: Darnell
authors.initials: D
authors.lastname: Kaigler
authors.forename: Gustavo
authors.initials: G
authors.lastname: Avila
authors.forename: Leslie
authors.initials: L
authors.lastname: Wisner-Lynch
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: Giulio
authors.initials: G
authors.lastname: Rasperini
authors.forename: Samuel E
authors.initials: SE
authors.lastname: Lynch
authors.forename: William V
authors.initials: WV
authors.lastname: Giannobile
mesh_terms: D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous / Q000295:instrumentation / Q000379:methods; D015921:Dental Implants; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods; D006801:Humans; D016348:Osseointegration / Q000187:drug effects; D010510:Periodontal Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D015921:Dental Implants; D010982:Platelet-Derived Growth Factor; D011994:Recombinant Proteins