title: Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed "Click" reaction with a water-soluble bis(triazole) ligand.
abstract: Oxidation of protein (bovine albumin serum) by air still occurred under the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction conditions even in the presence of a Cu(I)-stabilizing tris(triazole) ligand. Anaerobic conditions not only avoided the oxidation of the protein, but also greatly accelerated the CuAAC reaction using a water-soluble bis(triazole) Cu(I) ligand.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: King
authors.initials: K
authors.lastname: Li
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Cai
mesh_terms: D000480:Alkynes / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D002417:Cattle; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D010084:Oxidation-Reduction; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D008024:Ligands; D014230:Triazoles; D014867:Water; D012710:Serum Albumin, Bovine; D003300:Copper