title: The role of STAT5 in the development, function, and transformation of B and T lymphocytes.
abstract: The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in the development and function of B and T lymphocytes. Of particular interest is the growing appreciation for the function of STAT5 as a transcriptional repressor. Finally, we discuss recent discoveries about the role of STAT5 in transformation of B and T lymphocytes.
authors.affiliation: University of Minnesota, Center for Immunology, Minneapolis, Minnesota, USA.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Heltemes-Harris
authors.forename: Mark J L
authors.initials: MJ
authors.lastname: Willette
authors.forename: Kieng B
authors.initials: KB
authors.lastname: Vang
authors.forename: Michael A
authors.initials: MA
authors.lastname: Farrar
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D050799:STAT5 Transcription Factor / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*
chemical_list: D050799:STAT5 Transcription Factor