title: Study of release speeds and bacteria inhibiting capabilities of drug delivery membranes fabricated via electrospinning by observing bacteria growth curves.
abstract: The study found that biodegradable drug delivery membranes that were fabricated from Poly(a-L-alanine) (PLLA) and chlorhexidine (CHX)-gluconate via electrospinning could steadily and continuously inhibit the growth of bacteria. Bacterial growth curves were used to evaluate on a real-time basis the relationship between drug delivery speeds of the membranes and growth rates of bacteria in different phases. The results showed that PLLA/CHX (50:50 in terms of volume) drug delivery membranes could do what drug delivery systems can normally do. SEM morphology observations, FTIR, and Raman spectra analyses were conducted on the drug delivery membranes. This is the first study that confirms that biodegradable CHX delivery membranes fabricated via electrospinning are a rate-preprogrammed drug delivery system by comparing the growth curves of competent cell and plasmid inserted competent cell, bacteria that are of the same strain but grow at different speeds due to the insertion.
authors.affiliation: Department of Mechanical Engineering, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu, 30010, Taiwan, ROC.
authors.forename: Yao Nan
authors.initials: YN
authors.lastname: Lin
authors.forename: Kai Ming
authors.initials: KM
authors.lastname: Chang
authors.forename: Shiang Cheng
authors.initials: SC
authors.lastname: Jeng
authors.forename: Ping Yu
authors.initials: PY
authors.lastname: Lin
authors.forename: Ray Quen
authors.initials: RQ
authors.lastname: Hsu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D002710:Chlorhexidine / Q000737:chemistry; D003513:Cycloheximide / Q000008:administration & dosage; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004563:Electrochemistry / Q000379:methods; D004926:Escherichia coli / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010455:Peptides / Q000737:chemistry; D010957:Plasmids / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D010455:Peptides; C019529:polyalanine; D003513:Cycloheximide; D002710:Chlorhexidine