title: New pregnane saponins from Ecdysanthera rosea and their cytotoxicity.
abstract: Two new pregnane saponins elucidated as ecdysantheroside A (1) and ecdysantheroside B (2) and six known compounds (3-8) based on spectral data (MS, IR, 1D and 2D NMR) were isolated from the stem bark of Ecdysanthera rosea. The cytotoxicity against six cell lines of these compounds was tested by MTT assay. The results revealed that compounds 5 and 7 showed cytotoxicity against all the cell lines. Compound 2 showed cytotoxicity against cells A549, MDA435, HepG2, and HUVEC, while compound 4 showed cytotoxicity against cells A549, CEM, and HUVEC. Compound 6 had cytotoxicity against the others except cell HepG2.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan 650204, PR China. xdzhu815@yahoo.com.cn
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhu
authors.forename: Guisheng
authors.initials: G
authors.lastname: Wu
authors.forename: Jianying
authors.initials: J
authors.lastname: Xiang
authors.forename: Huairong
authors.initials: H
authors.lastname: Luo
authors.forename: Shide
authors.initials: S
authors.lastname: Luo
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhu
authors.forename: Yifen
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D029062:Apocynaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D011278:Pregnanes / Q000302:isolation & purification*; D012503:Saponins / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011278:Pregnanes; D012503:Saponins; C560475:ecdysantheroside A; C560476:ecdysantheroside B