title: Clinical significance of STC1 gene expression in patients with colorectal cancer.
abstract: BACKGROUND
  Recent studies suggest that altered patterns of stanniocalcin 1 (STC1) gene expression have a role in human carcinogenesis. This study examined the relationship between the relative expression of the STC1 gene and clinicopathological factors in patients with colorectal cancer.
  
  
  METHODS
  Surgical specimens of cancer tissue and adjacent normal mucosa were obtained from 202 patients with colorectal carcinomas. The relative expression levels of STC1 mRNA in the cancer and the normal adjacent mucosa were measured by quantitative real-time, reverse-transcriptase polymerase chain reaction.
  
  
  RESULTS
  The relative expression levels of the STC1 gene were higher in the cancer tissue than in the normal adjacent mucosa and high expression of STC1 correlated with poor postoperative survival.
  
  
  CONCLUSIONS
  High expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer.
authors.affiliation: Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
authors.forename: Shuzo
authors.initials: S
authors.lastname: Tamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoshihara
authors.forename: Amane
authors.initials: A
authors.lastname: Kanazawa
authors.forename: Takanobu
authors.initials: T
authors.lastname: Yamada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Inagaki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Shiozawa
authors.forename: Soichiro
authors.initials: S
authors.lastname: Morinaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Akaike
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Tanaka
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000556:secondary / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
chemical_list: D006023:Glycoproteins; C051795:teleocalcin