title: Lacticin Q-mediated selective toxicity depending on physicochemical features of membrane components.
abstract: Lacticin Q, a lactococcal pore-forming bacteriocin, shows activity toward Gram-positive bacteria but not Gram-negative bacteria. Lacticin Q did not induce permeability of the outer membrane of Gram-negative bacteria. Experiments using model membranes containing outer membrane components suggested that lacticin Q binds to the outer membrane of Gram-negative bacteria but is unable to penetrate it. The lack of activity of lacticin Q was attributed to physicochemical features of the outer membrane components.
authors.affiliation: Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Yoneyama
authors.forename: Kanako
authors.initials: K
authors.lastname: Ohno
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Imura
authors.forename: Mengqi
authors.initials: M
authors.lastname: Li
authors.forename: Takeshi
authors.initials: T
authors.lastname: Zendo
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Katsumi
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Sonomoto
mesh_terms: D001430:Bacteriocins / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008954:Models, Biological
chemical_list: D001430:Bacteriocins; C548356:lacticin Q, Lactococcus lactis