title: Oleoyl-estrone.
abstract: Oleoyl-estrone (OE) is a powerful slimming agent that is also present in plasma and adipose tissue, where it is synthesized. It acts through the formation of a derivative W. OE effects (and W levels) are proportional to the dose. OE reduces food intake but maintains energy expenditure (thermogenesis). The energy gap is fulfilled with adipose tissue fat, sparing body protein and maintaining glycemia (and glycogen) with lower insulin and leptin levels. OE (in fact W) acts through specific receptors, different from those of estrogen. OE increases cholesterol catabolism, reducing hypercholesterolemia in obese rats. The main metabolic effect on adipose tissue is lowering of lipid synthesis, maintaining unchanged the intracellular lipolytic processes; the imbalance favors the progressive loss of fat, which is largely used by the muscle. OE administration induces additive effects with other antiobesity agents, such as β(3)-adrenergic agonists, forcing a massive loss of lipid. Corticosteroids markedly limit OE action by altering the liver control of lipogenesis. OE also inhibits the action of 17β-hydroxysteroid dehydrogenase, decreasing the synthesis of β-estradiol and testosterone. Discontinuous treatment allows for maximal efficacy both in rats and humans. OE has the advantage that the loss of fat is maintained and does not require additional dietary limitations.
authors.affiliation: Department of Nutrition and Food Science, Faculty of Biology, University of Barcelona, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Remesar
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Fernández-López
authors.forename: Marià
authors.initials: M
authors.lastname: Alemany
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects; D004970:Estrone / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007333:Insulin Resistance; D008074:Lipoproteins / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy; D009829:Oleic Acids / Q000097:blood / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D008074:Lipoproteins; D009829:Oleic Acids; D011956:Receptors, Cell Surface; D004970:Estrone; C108709:oleoyl-estrone