title: Three new 18-oxygenated ent-kaurane diterpenoids from Isodon leucophyllus.
abstract: Three new 18-oxygenated ent-kaurane diterpenoids, isoleuconins A-C (1-3) and ten known diterpenoids were isolated from the aerial parts of Isodon leucophyllus. The structures were elucidated by 1D and 2D NMR spectroscopic analysis. All of the compounds were evaluated for their cytotoxicity. Rabdokunmin A (13) showed significant cytotoxicity against HT-29 cells, with an IC50 value of 6.2 microM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Hai Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Jian Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Li Guang
authors.initials: LG
authors.lastname: Lou
authors.forename: Wei Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane