title: Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating.
abstract: We have incorporated bisphosphonates and antibiotics simultaneously into a biomimetic hydroxyapatite implant coating aiming to use the interaction between drug-molecules and hydroxyapatite to enable local release of the two different substances to obtain a dual biological effect. A sustained release over for 43 h of antibiotics (cephalothin) was achieved without negative interference from the presence of the bisphosphonate (clodronate) which, in turn, successfully bonded to the coating surface. To our knowledge, this is the first study that indicates the possibility to simultaneously incorporate both antibiotics and bisphosphonates to an implant coating, a strategy that is believed to improve implant stability and reduce implant-related infections.
authors.affiliation: Department of Engineering Sciences, Uppsala University, P.O Box 534, 751 21, Uppsala, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Forsgren
authors.forename: Ulrika
authors.initials: U
authors.lastname: Brohede
authors.forename: Maria
authors.initials: M
authors.lastname: Strømme
authors.forename: Håkan
authors.initials: H
authors.lastname: Engqvist
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D040761:Biomimetic Materials / Q000737:chemistry*; D032701:Biomimetics; D001709:Biotechnology; D002512:Cephalothin / Q000008:administration & dosage; D004002:Clodronic Acid / Q000008:administration & dosage; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004164:Diphosphonates / Q000008:administration & dosage*; D004343:Drug Implants / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004164:Diphosphonates; D004343:Drug Implants; D004002:Clodronic Acid; D017886:Durapatite; D002512:Cephalothin