title: Raging hormones: gender and renal disease.
abstract: Gender affects the progression of renal disease. In a variety of animal models and in certain human renal diseases, females exhibit a more modest course of kidney disease. Estrogens and testosterone have been implicated in this gender disparity. Doublier and colleagues explore the direct effects of sex hormones on podocyte viability in the α-estrogen receptor knockout (αERKO) mouse. They report that testosterone induces, and estradiol inhibits, podocyte damage in this model.
authors.affiliation: Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York 10467, USA. ssilbige@montefiore.org
authors.forename: Sharon R
authors.initials: SR
authors.lastname: Silbiger
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D004958:Estradiol / Q000494:pharmacology; D047628:Estrogen Receptor alpha / Q000172:deficiency / Q000235:genetics; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D050199:Podocytes / Q000187:drug effects / Q000473:pathology; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology
chemical_list: D047628:Estrogen Receptor alpha; D012739:Gonadal Steroid Hormones; D013739:Testosterone; D004958:Estradiol