title: A comparative study of bone mineral density between premenopausal women with hyperthyroidism and healthy premenopausal women.
abstract: OBJECTIVE
  To compare bone mineral density (BMD) of the lumbar spine (L1-L4), total hip (TH), and femoral neck (FN) analyzed by Dual Energy X-ray Absorptiometry (DXA) in premenopausal women with hyperthyroidism and in healthy premenopausal women.
  
  
  METHODS
  Cross-sectional study included 49 premenopausal women with hyperthyroidism and 49 healthy premenopausal women. Age, weight and body mass index (BMI) were comparable in both groups. All subjects had a BMD measurement by DXA in the region of L1-L4, TH and FN and the unpaired t-test was used to analyze.
  
  
  RESULTS
  The mean BMD of premenopausal women with hyperthyroidism at L1-L4, TH and FN was 0.928, 0.838 and 0.774 g/cm2, which were lower than those of healthy premenopausal women; 0.991, 0.917 and 0.832 g/cm2 respectively (p-value is less than 0.05). Time interval that had elapsed for active hyperthyroidism was not associated with the decrease of BMD at L1-L4, TH and FN in hyperthyroid women.
  
  
  CONCLUSIONS
  The BMD of L1-L4, TH and FN in premenopausal women with hyperthyroidism were significantly lower than those of healthy premenopausal women. Therefore, overt hyperthyroidism could be associated with bone loss and may be a risk factor for the development of osteoporosis. However, time interval of active hyperthyroidism was not related to the decrease of BMD in hyperthyroid women.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Phramongkutklao Hospital, Bangkok, Thailand. triratsa@hotmail.com
authors.forename: Trirat
authors.initials: T
authors.lastname: Boonya-Ussadorn
authors.forename: Boondharika
authors.initials: B
authors.lastname: Punkaew
authors.forename: Narongchai
authors.initials: N
authors.lastname: Sriassawaamorn
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015992:Body Mass Index; D015519:Bone Density; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck; D006615:Hip; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications*; D008159:Lumbar Vertebrae; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology; D017697:Premenopause