title: Evaluation of the SUV values calculation and 4D PET integration in the radiotherapy treatment planning system.
abstract: OBJECTIVE
  To evaluate the SUV calculation and integration of the gated (4D) PET in the iPlan 4.0 treatment planning software (BrainLAB).
  
  
  METHODS
  Phantom and patient data for different tracers were used. Two comparisons were performed for each patient: for the delineated VOI, the maximum value of SUV in iPlan was compared with the results from TrueD software. For 10 patients lesion volumes were defined in both systems for a given SUV threshold and differences were calculated. For four patients examined with respiratory gated PET, SUV(max) and volume analysis was performed in each phase of the breathing cycle in the gated and the ungated PET.
  
  
  RESULTS
  Maximum differences of 6% and 10% were found for phantom and patient measurements of SUV(max). For patient data, maximal differences in delineated volume of 10% for ungated and up to 27% for gated PET were found in both systems.
  
  
  CONCLUSIONS
  This study suggests that for the safe implementation of PET data and delineation algorithms in the radiotherapy planning system, one has to be aware of the differences in SUVs and volumes found in the two systems.
authors.affiliation: Klinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Munich, Germany. vesna.jacob@uniklinik-freiburg.de
authors.forename: Vesna
authors.initials: V
authors.lastname: Jacob
authors.forename: Sabrina T
authors.initials: ST
authors.lastname: Astner
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Bundschuh
authors.forename: Raymonde
authors.initials: R
authors.lastname: Busch
authors.forename: Michael
authors.initials: M
authors.lastname: Souvatzoglou
authors.forename: Christina
authors.initials: C
authors.lastname: Wendl
authors.forename: Peter
authors.initials: P
authors.lastname: Kneschaurek
authors.forename: Anca-Ligia
authors.initials: AL
authors.lastname: Grosu
mesh_terms: D000465:Algorithms; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D049268:Positron-Emission Tomography; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*