title: Cerebrospinal fluid diagnostics in first-episode schizophrenia.
abstract: We evaluated the clinical use and the safety of cerebrospinal fluid diagnostics in 155 patients with the suspected diagnosis of first-episode schizophrenia. Five patients (3.2%) revealed pathological findings that lead to diagnostic re-evaluation and changes in clinical management. No serious adverse events occurred, but we documented 16 (10.3%) cases of mild to moderate headache or local pain at the puncture site. Our results underline the value of lumbar puncture in the clinical workup of first-episode patients with suspected schizophrenia.
authors.affiliation: Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159, Mannheim, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Kranaster
authors.forename: Dagmar
authors.initials: D
authors.lastname: Koethe
authors.forename: Carolin
authors.initials: C
authors.lastname: Hoyer
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer-Lindenberg
authors.forename: F Markus
authors.initials: FM
authors.lastname: Leweke
mesh_terms: D000328:Adult; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid / Q000145:classification; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D007136:Immunoglobulins