title: Silver/hydroxyapatite composite coatings on porous titanium surfaces by sol-gel method.
abstract: Hydroxyapatite (HA) coatings loaded with nanosilver particles is an attractive method to impart the HA coating with antibacterial properties. Producing Ag/HA coatings on porous Ti substrates have been an arduous job since commonly used line-of-sight techniques are not able to deposit uniform coatings on the inner pore surfaces of the porous Ti. In this study, porous Ti scaffolds with high porosity and interconnected structures were prepared by polymer impregnating method. A sol-gel process was used to produce uniform Ag/HA composite coatings on the surfaces of porous Ti substrates. Ca(NO(3) )(2) ·4H(2) O and P(2) O(5) in an ethyl alcohol based system was selected to prepare the sol, which ensured the homogeneous distribution of Ag in the sol. The characterization revealed that silver particles uniformly distributed in the coatings without agglomeration. High antibacterial ratio (>95%), against E. coli and S. albus was expressed by the silver-containing coatings (Ag/HA 0.8 and 1.6 wt %). The biocompatibility of the Ag/HA 0.8 surfaces was as good as that of pure HA surface, as revealed by culturing osteoblasts on them. The results indicated that Ag/HA 0.8 had the good balance between the biocompatibility and antibacterial properties of the coatings.
authors.affiliation: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qu
authors.forename: Xiong
authors.initials: X
authors.lastname: Lu
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Ding
authors.forename: Yang
authors.initials: Y
authors.lastname: Leng
authors.forename: Jie
authors.initials: J
authors.lastname: Weng
authors.forename: Shuxin
authors.initials: S
authors.lastname: Qu
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.forename: Fumio
authors.initials: F
authors.lastname: Watari
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004926:Escherichia coli / Q000254:growth & development; D008422:Materials Testing / Q000379:methods*; D010006:Osteoblasts; D044367:Phase Transition; D016062:Porosity; D051381:Rats; D012834:Silver / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D012834:Silver; D017886:Durapatite; D014025:Titanium