title: Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report.
abstract: Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare neoplasm arising from the antigen-presenting cells of the immune system. This disease usually involves the lymph nodes, and rarely, extranodal sites may be affected. The authors report a case of extranodal IDCS presenting in the pleura. A 32-yr-old man presented with progressive chest pain. Imaging studies showed diffuse pleural thickening with pleural effusion. Morphological and immunohistochemical analysis of an incisional biopsy of the pleura were consistent with a diagnosis of IDCS; tumor cells were positive for S100 and CD45, but negative for CD1a, CD21, CD35, B cell and T cell markers. The patient was administered chemotherapy, but died of progressive disease. Although its incidence is extremely rare, this case suggests that extranodal IDCS should be considered in the differential diagnosis of undifferentiated neoplasms and that immunohistochemical staining be performed using appropriate markers.
authors.affiliation: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
authors.forename: Hye-Suk
authors.initials: HS
authors.lastname: Han
authors.forename: Ok-Jun
authors.initials: OJ
authors.lastname: Lee
authors.forename: Sung-nam
authors.initials: SN
authors.lastname: Lim
authors.forename: Jin Young
authors.initials: JY
authors.lastname: An
authors.forename: Ki Man
authors.initials: KM
authors.lastname: Lee
authors.forename: Kang Hyeon
authors.initials: KH
authors.lastname: Choe
authors.forename: Ki Hyeong
authors.initials: KH
authors.lastname: Lee
authors.forename: Seung Taik
authors.initials: ST
authors.lastname: Kim
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D054739:Dendritic Cell Sarcoma, Interdigitating / Q000175:diagnosis / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D010994:Pleura / Q000473:pathology*; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor