title: Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome.
abstract: OBJECTIVE
  The very late antigen-4 (VLA-4) bound to vascular cell adhesion molecule-1 could provide co-stimulatory signals for the activation of T lymphocytes, and these adhesion molecules play key roles in leukocyte adherence and propagation of inflammatory responses. We examined the levels of VLA-4 in the peripheral blood mononuclear cells (PBMC) of patients with hemorrhagic fever with renal syndrome (HFRS).
  
  
  METHODS
  The levels of VLA-4 in PBMC samples collected from 53 patients by immunohistochemical staining were detected.
  
  
  RESULTS
  The expression of VLA-4 in PBMC of HFRS patients at different stages were significantly higher than those in normal controls (P < 0.05), except recovery stage (P > 0.05). The expression of VLA-4 in PBMC of HFRS patients at different types were significantly higher than those in healthy controls (P < 0.05). The levels of VLA-4 in patients with HFRS were positively correlated with serum levels of blood urea nitrogen (BUN) and creatinine (Cr).
  
  
  CONCLUSIONS
  VLA-4 might play an important role in the immunopathological lesions of HFRS. We found that VLA-4 levels were closely correlated to the severity of the HFRS and the degree of kidney damage.
authors.affiliation: Department of Pathogenic Microbiology and Immunology, Medical School of Xi'an Jiaotong University, Xi'an 710061, China. xieming@mail.xjtu.edu.cn
authors.forename: Ming
authors.initials: M
authors.lastname: Xie
authors.forename: Yanying
authors.initials: Y
authors.lastname: Dong
authors.forename: Linjing
authors.initials: L
authors.lastname: He
authors.forename: Huixun
authors.initials: H
authors.lastname: Ren
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Ji
authors.forename: Shemin
authors.initials: S
authors.lastname: Lv
mesh_terms: D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D039041:Integrin alpha4beta1 / Q000276:immunology*; D007668:Kidney / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology*
chemical_list: D039041:Integrin alpha4beta1