title: Evaluation of the early phase of Bell's palsy using 3 T MRI.
abstract: This prospective study on Bell's palsy investigated the value of 3 T MRI as a diagnostic tool to evaluate pathophysiological changes (i.e. edema) of facial nerve segments and the possibility to differentiate patients with high risk for incomplete recovery from patients who recover completely within 3 days after symptoms onset. For this institutional review board approved investigation, thirty patients (14 male, 16 female, mean age 44 years) with Bell's palsy underwent pre and postcontrast 3 T MRI of the cerebellopontine angle. T1-weighted imaging was performed (TR 20.0 ms, TE 2.46 ms, isotropic voxel size: 0.6 mm). Region-of-interest measurements were performed on the healthy and paralyzed side. To obtain normalized values, signal intensity increase percentage (SIIP) values were divided by contralateral results of the healthy side. Signal intensity measurements of examined nerve segments were compared using Wilcoxon and Mann-Whitney U tests and correlated to clinical findings categorized by the House-Brackmann score. The lesion side showed significantly higher signal intensities in the premeatal segment before and after contrast agent administration (P < 0.001). SIIP was highest in the premeatal segment compared to the geniculate ganglion (P < 0.001). Correlation analyses revealed no association between signal intensity measurements, clinical findings or early recovery rates after 3 months (P > 0.05). According to our results, early palsy-associated pathophysiological changes in the facial nerve premeatal segment might also be related to accumulation of proteins and not exclusively to edema. However, contrast agent enhancement quantification was not suitable as a diagnostic tool to distinguish different prognostic groups.
authors.affiliation: Institute of Diagnostic and Interventional Radiology, University Hospital-Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany. hartmut.burmeister@med.uni-jena.de
authors.forename: Hartmut Peter
authors.initials: HP
authors.lastname: Burmeister
authors.forename: Pascal Andreas Thomas
authors.initials: PA
authors.lastname: Baltzer
authors.forename: Gerd Fabian
authors.initials: GF
authors.lastname: Volk
authors.forename: Carsten Michael
authors.initials: CM
authors.lastname: Klingner
authors.forename: Anke
authors.initials: A
authors.lastname: Kraft
authors.forename: Matthias
authors.initials: M
authors.lastname: Dietzel
authors.forename: Otto Wilhelm
authors.initials: OW
authors.lastname: Witte
authors.forename: Werner Alois
authors.initials: WA
authors.lastname: Kaiser
authors.forename: Orlando
authors.initials: O
authors.lastname: Guntinas-Lichius
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D020330:Bell Palsy / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005154:Facial Nerve / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005830:Geniculate Ganglion / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D055815:Young Adult