title: Risk factors and outcome of seizures after chronic subdural hematoma.
abstract: BACKGROUND
  Seizures are important neurologic complications of chronic subdural hematoma (CSDH). A better understanding of risk factors of seizures following CSDH is needed to identify the patient who will require treatment.
  
  
  METHODS
  This one-year retrospective study enrolled 100 adult CSDH patients. Baseline prognostic variables were analyzed by Cox's proportional hazards model after a minimum of 18 months of follow-up.
  
  
  RESULTS
  Seizures occurred in 11 CSDH patients, including acute symptomatic seizures in 6.0% (6/100) and unprovoked seizures in 5.0% (5/100). None progressed to status epilepticus during hospitalization. After a minimum of 18 months of follow-up, the mean Glasgow Outcome Scores (GOSs) were 4.1 ± 1.4 and 4.7 ± 0.7 for patients with and without seizures, respectively. Cox's proportional hazards model showed that only the mean GCS on admission (P = 0.004, OR = 0.78, 95% CI = 0.67-0.93) was independently associated with seizures, and a decrease of one mean GCS increased the seizure rate by 21.6%.
  
  
  CONCLUSIONS
  Lower mean GCS on admission is independently predictive of seizures, most of which occur within the first three months after CSDH.
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Huang
authors.forename: Tzu-Ming
authors.initials: TM
authors.lastname: Yang
authors.forename: Yu-Jun
authors.initials: YJ
authors.lastname: Lin
authors.forename: Nai-Wen
authors.initials: NW
authors.lastname: Tsai
authors.forename: Wei-Che
authors.initials: WC
authors.lastname: Lin
authors.forename: Hung-Chen
authors.initials: HC
authors.lastname: Wang
authors.forename: Wen-Neng
authors.initials: WN
authors.lastname: Chang
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D020200:Hematoma, Subdural, Chronic / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants