title: Microbial transformation of marine halogenated sesquiterpenes.
abstract: The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus niger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new compounds obtained were determined by spectroscopic means.
authors.affiliation: Universidad de Chile, Facultad de Ciencias, Casilla 653, Santiago, Chile. aurelio@uchile.cl
authors.forename: Aurelio
authors.initials: A
authors.lastname: San Martin
authors.forename: Juana
authors.initials: J
authors.lastname: Rovirosa
authors.forename: Alvaro
authors.initials: A
authors.lastname: Carrasco
authors.forename: Silvia
authors.initials: S
authors.lastname: Orejarena
authors.forename: Jorge
authors.initials: J
authors.lastname: Soto-Delgado
authors.forename: Renato
authors.initials: R
authors.lastname: Contreras
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Chamy
mesh_terms: D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy; D009089:Mucor / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; C094445:pacifenol