title: Safety of thrombolytic therapy for acute ischemic stroke after recent transient ischemic attack.
abstract: BACKGROUND
  The objective of this study was to assess the rate of symptomatic intracerebral hemorrhage (SICH) in patients given thrombolytic therapy for acute ischemic stroke (AIS) after recent transient ischemic attack (TIA).
  
  
  METHODS
  This was a multicenter study of patients with confirmed TIA within 7 days before an AIS that was treated with intravenous (IV), intra-arterial (IA), or mechanical thrombolysis. A total of 23 cases were identified.
  
  
  RESULTS
  The median time interval between index TIA and AIS was 9 hours. The median National Institutes of Health Stroke Scale score at the time of AIS was 12. The median time interval between stroke onset and thrombolytic treatment was 90 minutes. Thrombolytic therapies included IV thrombolysis (70%), IA thrombolysis (17%), IA and mechanical thrombolysis (9%), and IV followed by IA and mechanical thrombolysis (4%). The rate of postthrombolysis SICH in this group was 8.6% (2/23).
  
  
  CONCLUSIONS
  The rate of SICH in our cohort appears similar to overall postthrombolysis hemorrhage rates.
authors.affiliation: Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08901, USA. mckinnjs@umdnj.edu
authors.forename: James S
authors.initials: JS
authors.lastname: McKinney
authors.forename: Jaime
authors.initials: J
authors.lastname: Masjuan
authors.forename: Francisco
authors.initials: F
authors.lastname: Purroy
authors.forename: David
authors.initials: D
authors.lastname: Calvet
authors.forename: Hakan
authors.initials: H
authors.lastname: Ay
authors.forename: Brett L
authors.initials: BL
authors.lastname: Cucchiara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis; D005060:Europe; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000175:diagnosis; D008297:Male; D061185:Mechanical Thrombolysis / Q000009:adverse effects*; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D005343:Fibrinolytic Agents