title: Primary cervical tracheal monophasic synovial sarcoma confirmed by  SYT-SSX gene rearrangement.
abstract: OBJECTIVE
  To review the existing diagnostic modalities and treatment for primary tracheal synovial sarcoma, and to report a case of primary cervical synovial sarcoma arising in the trachea.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  Head and neck surgery unit at a tertiary university centre.
  
  
  METHODS
  One case of primary cervical tracheal monophasic synovial sarcoma diagnosed by SYT-SSX gene rearrangement.
  
  
  METHODS
  This patient underwent surgical resection of the synovial sarcoma, together with tracheal resection and primary anastomosis assisted by laryngeal-releasing manoeuvres, without complication.
  
  
  METHODS
  Clinical, radiographical, pathological and surgical information were collected.
  
  
  RESULTS
  One year post-operatively, there was no evidence of recurrence.
  
  
  CONCLUSIONS
  Synovial sarcoma arising in the trachea is very rare. Diagnosis is confirmed by demonstrating the SYT-SSX gene rearrangement. The first-line treatment is surgery.
authors.affiliation: Department of Otolaryngology, Stanford University, California, USA. edamrose@ohns.stanford.edu
authors.forename: C E
authors.initials: CE
authors.lastname: Corrales
authors.forename: G
authors.initials: G
authors.lastname: Berry
authors.forename: E J
authors.initials: EJ
authors.lastname: Damrose
mesh_terms: D001706:Biopsy; D004417:Dyspnea / Q000209:etiology; D005260:Female; D015321:Gene Rearrangement; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007828:Laryngoscopy; D008875:Middle Aged; D009333:Neck; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012189:Retrospective Studies; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D014134:Tracheal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D014139:Tracheostomy; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein