title: Clinical experience of revision of metal on metal hip arthroplasty for aseptic lymphocyte dominated vasculitis associated lesions (ALVAL).
abstract: There has been growing concern regarding the systemic and local effects of metal ions released from metal-on-metal hip resurfacings and total hip replacements, including the development of aseptic lymphocyte dominated vasculitis associated lesions (ALVAL). We describe our experience of treating 13 patients with failed metal on metal bearing hip prostheses secondary to this condition. Hip revision occurred at mean of 45 months following primary surgery. Groin pain was present in all patients. Other common features included large bursal swelling and mechanical symptoms. 3 patients developed their symptoms immediately postoperatively. The mean time to presentation was 21 months. Radiographic abnormalities noted included 3 patients with cup loosening and 2 patients with neck thinning. The mean cup inclination was 52 degrees. Surgical findings included bursal swellings and creamy brown fluid. Osteolysis was rarely seen. 12 revisions were achieved with primary implants and all patients had immediate symptomatic improvement. One patient was left with a pseudoarthrosis due to extensive soft tissue destruction. Diagnosis of ALVAL was confirmed histologically. The diagnosis of ALVAL should be considered in patients with unexplained pain from a metal on metal bearing hip arthroplasty. Surgical findings are typical and symptoms tend to resolve reliably following conversion to an alternative bearing surface.
authors.affiliation: Centre for Hip Surgery, Wrightington Hospital, Wigan, UK. asimrajpura@gmail.com
authors.forename: Asim
authors.initials: A
authors.lastname: Rajpura
authors.forename: Martyn L
authors.initials: ML
authors.lastname: Porter
authors.forename: Anil K
authors.initials: AK
authors.lastname: Gambhir
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Freemont
authors.forename: Timothy N
authors.initials: TN
authors.lastname: Board
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D011474:Prosthesis Design; D011475:Prosthesis Failure / Q000209:etiology*; D012086:Reoperation; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D008670:Metals