title: Unexpected role of nucleoporins in coordination of cell cycle progression.
abstract: Many human cancers have irregular chromosome content, a condition known as aneuploidy. Several nuclear pore proteins (nucleoporins/Nups) that mediate transport of RNA or macromolecules into and out of the nucleus have been implicated in mitosis. These nucleoporins are involved in molecular networks that function in a variety of mitotic processes, including chromosome condensation, sister chromatid cohesion, kinetochore assembly and spindle formation. An alteration in the concentration of Nups inside cells often causes aneuploidy. In this review, we discuss this sprouting area and the possible functions of Nups during mitosis.
authors.affiliation: Frontier Science Organization, Kanazawa University, Kanazawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Chieko
authors.initials: C
authors.lastname: Hashizume
authors.forename: Tatsuyoshi
authors.initials: T
authors.lastname: Funasaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Richard W
authors.initials: RW
authors.lastname: Wong
mesh_terms: D021581:Active Transport, Cell Nucleus; D002453:Cell Cycle; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D022022:Nuclear Pore / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D028861:Nuclear Pore Complex Proteins / Q000737:chemistry / Q000502:physiology*
chemical_list: D028861:Nuclear Pore Complex Proteins