title: [Immunohistochemical expression of HO-1 in traumatic human brain tissue].
abstract: OBJECTIVE
  To investigate the expression of heme oxygenase-1 (HO-1) at different intervals and to provide evidence for estimation on injury intervals after brain contusion in human.
  
  
  METHODS
  Twenty-four patients died of serious brain injury were assigned as injury group and 4 patients died of non-brain injury were served as control group. HO-1 expression was analyzed in brain tissue at different time intervals (3 h, 6-9 h, 12-24 h, 36 h-3d, 5-8d, 17-20d) by immunohistochemistry and auto-image analysis system.
  
  
  RESULTS
  The level of HO-1 expression started to increase in 3 h after brain contusion compared to the control group (P < 0.05). The level of HO-1 expression highest level in 12-24 h group, and maintained high level in 36 h-3 d, then decreased gradually.
  
  
  CONCLUSIONS
  The expression of HO-1 might be a strong evidence for human brain contusion time estimation.
authors.affiliation: Department of Forensic Medicine, Harbin Medical University, Harbin 150081, China. flysnow990119@l26.com
authors.forename: Xue
authors.initials: X
authors.lastname: Peng
authors.forename: Zhan-Feng
authors.initials: ZF
authors.lastname: Jin
authors.forename: Hong-Jiang
authors.initials: HJ
authors.lastname: Shao
authors.forename: Tie-Lei
authors.initials: TL
authors.lastname: Gao
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001344:Autopsy; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D049429:Forensic Pathology; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D013997:Time Factors; D055815:Young Adult
chemical_list: C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1