title: Cycloisomerization of 1,n-enynes via carbophilic activation.
abstract: Metal-catalyzed cycloisomerization of 1,n-enynes has appeared as a highly attractive methodology for the synthesis of original carbo- and heterocycles. This chapter intends to propose an overview of the recent and seminal advances in 1,n-enynes cycloisomerization reactions in the presence of carbophilic transition metals. The recent mechanistic insights, the enantioselective versions, and the applications in total synthesis are highlighted.
authors.affiliation: Laboratoire Charles Friedel, Ecole Nationale Supérieure de Chimie de Paris, Chimie ParisTech, France.
authors.forename: Patrick Yves
authors.initials: PY
authors.lastname: Toullec
authors.forename: Véronique
authors.initials: V
authors.lastname: Michelet