title: Triterpenoid saponins from Symplocos lancifolia.
abstract: Three new bidesmosidic saponins (1-3) and a new ursane triterpenoid, 2α,3β,11α,23-tetrahydroxyurs-12-en-28-oic acid (4), along with seven known compounds, were isolated from a methanolic extract of the leaves of Symplocos lancifolia. The bidesmosidic saponins were found to possess the same sugar unit part, composed of two β-d-glucose moieties and one α-l-rhamnose moiety, linked to maslinic acid, arjunolic acid, and asiatic acid, respectively. Their structures were elucidated by interpretation of their 1D and 2D NMR spectra and completed by analysis of the HRESIMS data. The antibacterial activity of the isolated triterpenoids was evaluated against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, and several showed activity against Gram-positive bacteria.
authors.affiliation: Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, BP 1039, 51687 Reims, France.
authors.forename: Ivone Lucia
authors.initials: IL
authors.lastname: Acebey-Castellon
authors.forename: Laurence
authors.initials: L
authors.lastname: Voutquenne-Nazabadioko
authors.forename: Huong
authors.initials: H
authors.lastname: Doan Thi Mai
authors.forename: Nathalie
authors.initials: N
authors.lastname: Roseau
authors.forename: Naima
authors.initials: N
authors.lastname: Bouthagane
authors.forename: Dima
authors.initials: D
authors.lastname: Muhammad
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Le Magrex Debar
authors.forename: Sophie C
authors.initials: SC
authors.lastname: Gangloff
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Thierry
authors.initials: T
authors.lastname: Sevenet
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Hung
authors.forename: Catherine
authors.initials: C
authors.lastname: Lavaud
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014744:Vietnam; D009828:Oleanolic Acid / Q000031:analogs & derivatives
chemical_list: D000900:Anti-Bacterial Agents; D012503:Saponins; D014315:Triterpenes; C557421:11alpha-hydroxyasiatic acid; C557419:3-O-(beta-D-glucopyranosyl)-28-O-(alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl)arjunolic acid; C557420:3-O-(beta-D-glucopyranosyl)-28-O-(alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl)asiatic acid; C557418:3-O-(beta-D-glucopyranosyl)-28-O-(alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl)maslinic acid; C061640:arjunolic acid; C412811:maslinic acid; D009828:Oleanolic Acid