title: Chemical mediators of inflammation and resolution in post-operative abdominal aortic aneurysm patients.
abstract: Temporal-metabolomic studies of local mediators during inflammation and its resolution uncovered novel pathways and mediators, e.g., lipoxins, resolvins, and protectins that stimulate key resolution responses. Since these studies were carried out with isolated human cells and in animal models, it is important to determine in humans whether temporal profiles between pro-inflammatory mediators and pro-resolving mediators are demonstrable in vivo. To this end, we examined patients undergoing abdominal aortic aneurysm (AAA) surgery. Profiles of mediators including eicosanoids were assessed in addition to pro-resolving mediators. The results demonstrate temporal relationships for local-acting peptides (e.g., VEGF, IL-10, TGF(β)) and lipid mediators (leukotrienes and resolvins). In addition, profiles obtained for AAA patients divided into two groups based on their temporal profile: one group consistent with a pro-inflammatory and another with a resolving profile. Together, these translational metabolomic profiles demonstrate for the first time the temporal relationships between local mediators in humans relevant in inflammation resolution.
authors.affiliation: Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Padmini S
authors.initials: PS
authors.lastname: Pillai
authors.forename: Stanley
authors.initials: S
authors.lastname: Leeson
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Porter
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Owens
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Michael S
authors.initials: MS
authors.lastname: Conte
authors.forename: Charles N
authors.initials: CN
authors.lastname: Serhan
authors.forename: Simon
authors.initials: S
authors.lastname: Gelman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D018957:CD59 Antigens / Q000097:blood; D015777:Eicosanoids / Q000097:blood; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D016753:Interleukin-10 / Q000097:blood; D015289:Leukotrienes / Q000097:blood; D044045:Lipoxins / Q000097:blood; D008297:Male; D055432:Metabolomics; D008875:Middle Aged; D011184:Postoperative Period; D016212:Transforming Growth Factor beta / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D018957:CD59 Antigens; D015777:Eicosanoids; D018836:Inflammation Mediators; D015289:Leukotrienes; D044045:Lipoxins; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10