title: Focused extracorporeal shockwave therapy in Dupuytren's disease--a hypothesis.
abstract: Dupuytren's disease is a progressive disease due to unknown causal agents or genetics. An epidemiological analysis of 566 cases in North Germany estimated that around 1.9 million Germans are suffering from Dupuytren's disease. Beside Dupuytren's disease, there are a number of further less common forms of progressive fibromatosis, such as knuckle pads, plantar fibromatosis or Peyronie's disease. Surgery in plantar fasciectomy yields to a 60% recurrence rate depending on the extent of the plantar fasciectomy. Peyronie's disease of the penis affects middle-aged men between 40 and 60 years with penile pain, curvature during erection and potential erectile dysfunction. In a clinical randomized-controlled trial in Peyronie's disease 2000 focused extracorporeal shock waves reduced pain significantly and improved erectile function and quality of life. We hypothesize that focused extracorporeal shock wave therapy is able to reduce Dupuytren's contracture, a fibromatosis of the palm and improve function. Given the fact that recurrence rate in Dupuytren's disease is high und unpredictable extracorporeal shockwave therapy as a non-invasive tool might be applicable both, in primary and secondary prevention of the progression as well as for treatment. As such we have planned a randomized-controlled trial (ClinicialTrials.gov, NCT01184586) studying the effect of high-energy focused extracorporeal shockwave therapy on patients suffering Dupuytren's disease with patient-related outcome measures such as the DASH score and the Michigan Hand Outcome Questionnaire (MHQ) as primary outcome parameters.
authors.affiliation: Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Germany. Knobloch.karsten@mh-hannover.de
authors.forename: Karsten
authors.initials: K
authors.lastname: Knobloch
authors.forename: Marie
authors.initials: M
authors.lastname: Kuehn
authors.forename: Peter M
authors.initials: PM
authors.lastname: Vogt
mesh_terms: D003240:Connective Tissue Diseases / Q000628:therapy; D018450:Disease Progression; D004387:Dupuytren Contracture / Q000628:therapy*; D005350:Fibroma; D006801:Humans; D008096:Lithotripsy / Q000379:methods*; D008297:Male; D008954:Models, Biological; D008962:Models, Theoretical; D010411:Penile Induration / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D011795:Surveys and Questionnaires; D016896:Treatment Outcome