title: Testosterone and the child (0-12 years) with Klinefelter syndrome (47XXY): a review.
abstract: OBJECTIVE
  To review the evidence base for providing testosterone therapy in the infant and prepubertal child with Klinefelter syndrome (KS).
  
  
  METHODS
  Major databases were searched to identify articles that addressed the role of testosterone in the development of the male foetus with and without KS and that characterized testicular function in infants with KS.
  
  
  RESULTS
  Infants with KS have been shown to have an increased frequency of clinical features consistent with deficient testosterone production. However, there are conflicting results regarding whether testosterone levels are low or normal. No direct data address the outcome of therapy in the prepubertal child.
  
  
  CONCLUSIONS
  There is an absence of data that directly address the risks and benefits of testosterone therapy in prepubertal children with KS outside of the entity of microphallus. At this time, there is no other documented benefit for testosterone therapy in these children.
authors.affiliation: Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA. if1@columbia.edu
authors.forename: Ilene
authors.initials: I
authors.lastname: Fennoy
mesh_terms: D000728:Androgens / Q000627:therapeutic use*; D002648:Child; D019317:Evidence-Based Medicine; D020249:Hormone Replacement Therapy; D006801:Humans; D007223:Infant; D007713:Klinefelter Syndrome / Q000188:drug therapy*; D008297:Male; D010413:Penis / Q000002:abnormalities; D018570:Risk Assessment; D013739:Testosterone / Q000172:deficiency / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000728:Androgens; D013739:Testosterone