title: Current usage and future directions for the bovine pericardial patch.
abstract: Bovine pericardium (BP) is widely used in surgery and is commonly used as a patch after arteriotomy in cardiovascular surgery. BP patches have several advantages compared with prosthetic patches, including superior biocompatability, easy handling, less suture line bleeding, and possibly reduced rates of infection. These advantages of BP have led to its common use during carotid endarterectomy (CEA). However, long-term clinical results reported after CEA have suggested several issues that may be related to the patch, including restenosis, pseudoaneurysm formation, infection, fibrosis, calcification, and thrombosis. These complications may diminish the long-term efficacy of CEA and suggest potential areas for improvement of surgical patches. Understanding the mechanisms by which BP heals after patch angioplasty may lead to next generation tissue-engineered patches.
authors.affiliation: Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Ziegler
authors.forename: Lynn S
authors.initials: LS
authors.lastname: Model
authors.forename: Sammy D D
authors.initials: SD
authors.lastname: Eghbalieh
authors.forename: Robert A
authors.initials: RA
authors.lastname: Brenes
authors.forename: Susun T
authors.initials: ST
authors.lastname: Kim
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: Alan
authors.initials: A
authors.lastname: Dardik
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation*; D002318:Cardiovascular Diseases / Q000601:surgery*; D002417:Cattle; D016894:Endarterectomy, Carotid / Q000295:instrumentation; D006801:Humans; D010496:Pericardium / Q000637:transplantation*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials