title: [Thrombinoscopy: measuring thrombin generation].
abstract: A test is needed of which the score is low in case of haemorrhagic tendency and high in case of thrombotic tendency. Emerging evidence shows that thrombin generation is a promising candidate. Recently it became possible to measure the course in thrombin concentration in clotting blood or blood plasma in an simple way suitable for application in a routine clinical setting. It appears that the amount of thrombin developing in clotting blood or blood plasma is a better measure for thrombotic- or haemorrhagic tendency than any variant of the clotting time and that thrombin generation is a universal test for the effect of antithrombotic drugs.
authors.affiliation: Synapse BV, Cardiovasculair Research Instituut Maastricht (CARIM), The Netherlands. hc.hemker@thrombin.com
authors.forename: H Coen
authors.initials: HC
authors.lastname: Hemker
mesh_terms: D001780:Blood Coagulation Tests / Q000379:methods* / Q000592:standards; D006470:Hemorrhage / Q000097:blood* / Q000175:diagnosis; D006487:Hemostasis; D006801:Humans; D012680:Sensitivity and Specificity; D013917:Thrombin / Q000096:biosynthesis*; D013927:Thrombosis / Q000097:blood* / Q000175:diagnosis
chemical_list: D013917:Thrombin