title: The effect of vitamin D treatment on serum adiponectin levels in children with vitamin D deficiency rickets.
abstract: OBJECTIVE
  Adiponectin and its receptors are known to be expressed in osteoblasts and may have important functions in normal bone cells. The aim of this study was to investigate the effect of vitamin D therapy on serum adiponectin levels in children with vitamin D deficiency rickets (VDDR).
  
  
  METHODS
  21 patients with VDDR were included in the study. Patients were treated with 300,000 U D3 (IM) and calcium lactate (50mg/kg/ day, PO, for 10 days). Anthropometric parameters and serum biochemical markers including calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), intact parathormone (iPTH), 25-hydroxyvitamin D (25(OH)D), and adiponectin levels were measured before and after one month of therapy.
  
  
  RESULTS
  Weight and length, but not BMI, increased significantly after treatment. Serum 25(OH)D level increased significantly after treatment, while serum adiponectin level decreased (4.21±1.84 vs 52.73±17.63 ng/ml, p<0.000; 150.1±66.14 vs 84.29±9.06 mg/ml, p<0.000, respectively). No significant correlations were found between serum adiponectin and 25(OH)D levels before and after treatment or between delta adiponectin concentrations and delta 25(OH)D levels.
  
  
  CONCLUSIONS
  Serum adiponectin levels are increased in patients with VDDR, a finding which is probably related to increased osteoblastic activity.
authors.affiliation: Atatürk University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Erzurum, Turkey. ozkan.behzat@gmail.com
authors.forename: Behzat
authors.initials: B
authors.lastname: Özkan
authors.forename: Hakan
authors.initials: H
authors.lastname: Döneray
authors.forename: Halil
authors.initials: H
authors.lastname: Keskin
mesh_terms: D052242:Adiponectin / Q000097:blood*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012279:Rickets / Q000097:blood* / Q000188:drug therapy*; D014807:Vitamin D / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D052242:Adiponectin; D014815:Vitamins; D014807:Vitamin D