title: An algorithm for genetic testing of frontotemporal lobar degeneration.
abstract: OBJECTIVE
  To derive an algorithm for genetic testing of patients with frontotemporal lobar degeneration (FTLD).
  
  
  METHODS
  A literature search was performed to review the clinical and pathologic phenotypes and family history associated with each FTLD gene.
  
  
  RESULTS
  Based on the literature review, an algorithm was developed to allow clinicians to use the clinical and neuroimaging phenotypes of the patient and the family history and autopsy information to decide whether or not genetic testing is warranted, and if so, the order for appropriate tests.
  
  
  CONCLUSIONS
  Recent findings in genetics, pathology, and imaging allow clinicians to use the clinical presentation of the patient with FTLD to inform genetic testing decisions.
authors.affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 W. 168th St., Box 16, New York, NY 10032, USA. jg2673@columbia.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Goldman
authors.forename: R
authors.initials: R
authors.lastname: Rademakers
authors.forename: E D
authors.initials: ED
authors.lastname: Huey
authors.forename: A L
authors.initials: AL
authors.lastname: Boxer
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
authors.forename: B F
authors.initials: BF
authors.lastname: Boeve
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D004252:DNA Mutational Analysis / Q000379:methods / Q000592:standards; D003663:Decision Trees; D003937:Diagnosis, Differential; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing / Q000191:economics / Q000379:methods* / Q000592:standards*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010641:Phenotype
chemical_list: D009419:Nerve Tissue Proteins