title: Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan.
abstract: The aim of this study was to evaluate the association of polymorphic genotypes in the cyclooxygenase 2 gene (COX2), which is reported to be overexpressed in prostate tumors, with Taiwan prostate cancer patients.
  
  
  METHODS
  Six polymorphic variants of COX2 were analyzed for their association with prostate cancer susceptibility. A total of 218 patients with prostate cancer and 436 healthy controls in central Taiwan were enrolled in this investigation. P-values and odds ratios with 95% confidence intervals were used to assess the strength of the association.
  
  
  RESULTS
  Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs14133) genotypes were distributed differently between the prostate cancer and control groups. The COX2 -765GG genotype was associated with higher prostate cancer risk than -765GC.
  
  
  CONCLUSIONS
  These findings provide evidence that the G allele of COX2 promoter G-765C may be associated with the development of prostate cancer and may be a useful marker for early detection of prostate cancer.
authors.affiliation: Terry Fox Cancer Research Lab, China Medical University Hospital, Taichung, Taiwan, ROC.
authors.forename: Hsi-Chin
authors.initials: HC
authors.lastname: Wu
authors.forename: Chao-Hsiang
authors.initials: CH
authors.lastname: Chang
authors.forename: Hung-Lung
authors.initials: HL
authors.lastname: Ke
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.forename: Hui-Ni
authors.initials: HN
authors.lastname: Cheng
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Lin
authors.forename: Chi-Yu
authors.initials: CY
authors.lastname: Wu
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Ru-Yin
authors.initials: RY
authors.lastname: Tsai
authors.forename: Woei-Chung
authors.initials: WC
authors.lastname: Lo
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D013624:Taiwan
chemical_list: D004273:DNA, Neoplasm; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human