title: The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen.
abstract: In an attempt to evaluate the role of inositol supplementation in insulin-resistant patients with polycystic ovary syndrome (PCOS), undergoing gonadotropin ovulation induction using the low-dose step-down regimen, we conducted a prospective longitudinal study comparing the stimulation characteristics of 15 patients treated with inositol, to a cohort, matched by age and body mass index (BMI), without inositol. Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40%) and the consequent improvement in clinical pregnancy rate (PR) (33.3% vs. 13.3%).
authors.affiliation: Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, Siena, Italy. morgante@unisi.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Morgante
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
authors.forename: Alessandra
authors.initials: A
authors.lastname: Di Sabatino
authors.forename: Maria C
authors.initials: MC
authors.lastname: Musacchio
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Leo
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D019587:Dietary Supplements; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007294:Inositol / Q000008:administration & dosage*; D007333:Insulin Resistance; D007558:Italy; D008137:Longitudinal Studies; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D006062:Gonadotropins; D007294:Inositol