title: Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids.
abstract: A one-pot synthesis of tetrahydroisoquinoline alkaloids in a phosphate buffer has been achieved, and a reaction mechanism proposed. The utilisation of mild reaction conditions readily afforded a range of isoquinolines, including norcoclaurine.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Pesnot
authors.forename: Markus C
authors.initials: MC
authors.lastname: Gershater
authors.forename: John M
authors.initials: JM
authors.lastname: Ward
authors.forename: Helen C
authors.initials: HC
authors.lastname: Hailes
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D032701:Biomimetics; D004298:Dopamine / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D010710:Phosphates / Q000737:chemistry*; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000470:Alkaloids; D010710:Phosphates; D044005:Tetrahydroisoquinolines; C012348:higenamine; D004298:Dopamine