title: Risk of diabetes after gestational diabetes and preeclampsia. A registry-based study of 230,000 women in Norway.
abstract: This study aimed to use a population-based Prescription Database to explore later development of diabetes in women registered with gestational diabetes mellitus (GDM) and/or preeclampsia in the Medical Birth Registry of Norway (MBRN) during 2004-8. We used two nationwide Norwegian registries, the Norwegian Prescription Database and the MBRN, to explore the onset of later diabetes after pregnancy complications, indicated by receiving prescriptions of drugs used to treat diabetes, in 230,000 women giving birth in 2004-8. The mean follow-up of the study cohort was 3.7 years. Five years after pregnancy, about 19 and 2% of women with GDM and preeclampsia, respectively, received drugs used to treat diabetes, compared to 0.5% of those without these complications. The risk of being dispensed drugs used to treat diabetes within the first years after pregnancy was estimated to be 41 times (95% CI: 35-47) and 3.0 times (95% CI: 2.4-3.6) higher in women with GDM and preeclampsia, respectively, compared to women without these pregnancy complications. Women with pregnancies complicated with preeclampsia or GDM had an increased risk of later diabetes, especially those having GDM. If the increase in frequency of GDM observed in MBRN in recent years is real, a further increase in diabetic women can be expected.
authors.affiliation: Department of Pharmacoepidemiology, Division of Epidemiology, Norwegian Institute of Public Health, Nydalen, Oslo, Norway. anders.engeland@isf.uib.no
authors.forename: Anders
authors.initials: A
authors.lastname: Engeland
authors.forename: Tone
authors.initials: T
authors.lastname: Bjørge
authors.forename: Anne Kjersti
authors.initials: AK
authors.lastname: Daltveit
authors.forename: Svetlana
authors.initials: S
authors.lastname: Skurtveit
authors.forename: Siri
authors.initials: S
authors.lastname: Vangen
authors.forename: Stein Emil
authors.initials: SE
authors.lastname: Vollset
authors.forename: Kari
authors.initials: K
authors.lastname: Furu
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D016640:Diabetes, Gestational; D011307:Drug Prescriptions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin; D009664:Norway; D011225:Pre-Eclampsia; D011247:Pregnancy; D016016:Proportional Hazards Models; D012042:Registries; D012306:Risk; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin