title: Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study.
abstract: Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory blood pressure measurements were taken for 101 black South African men and 99 women. The stiffness indices included ambulatory arterial stiffness index (AASI) and pulse pressure (PP). Reactive oxygen species (ROS) levels (P<0.0001) were higher in the African women compared with men. ROS levels were also higher in hypertensive compared with normotensive men. The 24 h systolic blood pressure (SBP; P<0.01), 24 h diastolic blood pressure (DBP; P<0.0001) and pulse wave velocity (PWV; P<0.01) were significantly higher in African men compared with women. There were unadjusted positive associations of 24 h SBP (r=0.33; P=0.001), 24 h DBP (r=0.26; P=0.008) and 24 h PP (r=0.29; P=0.003) with ROS in African men only. A positive association between AASI and ROS existed only in hypertensive men (r=0.27; P=0.035), but became nonsignificant (B=0.0014; P=0.14) after adjustments. Adjusted, positive associations of 24 h SBP (B=0.181; P=0.018) and 24 h PP (B=0.086; P=0.050) with ROS were again only evident in African men. ROS is positively associated with SBP and PP in African men, suggesting that increased ROS levels may contribute to hypertension in this population group.
authors.affiliation: Hypertension in Africa Research Team, North-West University (Potchefstroom Campus), Potchefstroom, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Kruger
authors.forename: R
authors.initials: R
authors.lastname: Schutte
authors.forename: H W
authors.initials: HW
authors.lastname: Huisman
authors.forename: J M
authors.initials: JM
authors.lastname: Van Rooyen
authors.forename: N T
authors.initials: NT
authors.lastname: Malan
authors.forename: C M T
authors.initials: CM
authors.lastname: Fourie
authors.forename: R
authors.initials: R
authors.lastname: Louw
authors.forename: F H
authors.initials: FH
authors.lastname: van der Westhuizen
authors.forename: C A
authors.initials: CA
authors.lastname: van Deventer
authors.forename: L
authors.initials: L
authors.lastname: Malan
authors.forename: A E
authors.initials: AE
authors.lastname: Schutte
mesh_terms: D000328:Adult; D001158:Arteries / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D044383:Black People / Q000706:statistics & numerical data*; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D016009:Chi-Square Distribution; D004548:Elasticity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000208:ethnology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018384:Oxidative Stress; D011673:Pulsatile Flow; D017382:Reactive Oxygen Species / Q000097:blood*; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013019:South Africa / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species