title: Multidisciplinary management of early and locally advanced esophageal cancer.
abstract: Clinical management of esophageal cancer is a multidisciplinary challenge. Diagnosis is associated with a high mortality and approximately 40% of patients have locally advanced disease at clinical presentation. Surgery remains one of the fundamental parts of treatment, but multimodal approaches including chemotherapy and radiation are associated with improved outcomes. This comprehensive review addresses the multidisciplinary management of early and locally advanced esophageal cancer.
authors.affiliation: Section of Surgical Oncology, Department of Surgery, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
authors.forename: Jussuf T
authors.initials: JT
authors.lastname: Kaifi
authors.forename: Niraj J
authors.initials: NJ
authors.lastname: Gusani
authors.forename: Yixing
authors.initials: Y
authors.lastname: Jiang
authors.forename: Heath B
authors.initials: HB
authors.lastname: Mackley
authors.forename: Charles E
authors.initials: CE
authors.lastname: Dye
authors.forename: Abraham
authors.initials: A
authors.lastname: Mathew
authors.forename: Eric T
authors.initials: ET
authors.lastname: Kimchi
authors.forename: Michael F
authors.initials: MF
authors.lastname: Reed
authors.forename: Kevin F
authors.initials: KF
authors.lastname: Staveley-O'Carroll
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D011878:Radiotherapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents