title: Relationship between carotid intima-media thickness and the presence and extent of coronary stenosis in type 2 diabetic patients with carotid atherosclerosis but without history of coronary artery disease.
abstract: OBJECTIVE
  We examined the relationship between the presence and extent of coronary stenosis and carotid intima-media thickness (CIMT) in type 2 diabetic patients without history of coronary artery disease (CAD) but with carotid atherosclerosis.
  
  
  METHODS
  A total of 91 type 2 diabetic patients underwent multi-slice computed tomography coronary angiography.
  
  
  RESULTS
  Max-IMT in the ≥ 50% stenosis group by multi-slice computed tomography coronary angiography estimation was significantly greater than the 0-25 and 25-50% stenosis group (2.68 ± 0.77 vs. 1.61 ± 0.49 mm, P < 0.0005, and 2.14 ± 0.81 mm, P < 0.05, respectively), and max-IMT in the 25-50% stenosis group was significantly greater than the 0-25% stenosis group (P < 0.05) after adjustment for age, sex, duration of type 2 diabetes, hypertension, and dyslipidemia. In the analysis for trend through the categories of max-IMT, as max-IMT increased, the percentage of ≥ 50% stenosis increased and the percentage of 0-25% stenosis decreased.
  
  
  CONCLUSIONS
  Our data suggest that max-IMT might be closely associated with the extent of coronary stenosis in type 2 diabetic patients without history of CAD but with carotid atherosclerosis.
authors.affiliation: Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Ryuuichi
authors.initials: R
authors.lastname: Kasami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Naoto
authors.initials: N
authors.lastname: Katakami
authors.forename: Satoru
authors.initials: S
authors.lastname: Sumitsuji
authors.forename: Keita
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kuroda
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tachibana
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Akio
authors.initials: A
authors.lastname: Kuroda
authors.forename: Taka-Aki
authors.initials: TA
authors.lastname: Matsuoka
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
mesh_terms: D000368:Aged; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D017023:Coronary Angiography / Q000379:methods; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging