title: Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care.
abstract: BACKGROUND
  Vaginitis is a common complaint in primary care. In uncomplicated candidal vaginitis, there are no differences in effectiveness between oral or vaginal treatment. Some studies describe that the preferred treatment is the oral one, but a Cochrane's review points out inconsistencies associated with the report of the preferred way that limit the use of such data. Risk factors associated with recurrent vulvovaginal candidiasis still remain controversial.
  
  
  METHODS
  This work describes a protocol of a multicentric prospective observational study with one year follow up, to describe the women's reasons and preferences to choose the way of administration (oral vs topical) in the treatment of not complicated candidal vaginitis. The number of women required is 765, they are chosen by consecutive sampling. All of whom are aged 16 and over with vaginal discharge and/or vaginal pruritus, diagnosed with not complicated vulvovaginitis in Primary Care in Madrid.The main outcome variable is the preferences of the patients in treatment choice; secondary outcome variables are time to symptoms relief and adverse reactions and the frequency of recurrent vulvovaginitis and the risk factors. In the statistical analysis, for the main objective will be descriptive for each of the variables, bivariant analysis and multivariate analysis (logistic regression).. The dependent variable being the type of treatment chosen (oral or topical) and the independent, the variables that after bivariant analysis, have been associated to the treatment preference.
  
  
  CONCLUSIONS
  Clinical decisions, recommendations, and practice guidelines must not only attend to the best available evidence, but also to the values and preferences of the informed patient.
authors.affiliation: Unidad de Investigación, Atención Primaria Area 9, Servicio Madrileño de Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain. icura.gapm09@salud.madrid.org.
authors.forename: Isabel
authors.initials: I
authors.lastname: Del-Cura González
authors.forename: Francisca
authors.initials: F
authors.lastname: García-de-Blas González
authors.forename: Teresa Sanz
authors.initials: TS
authors.lastname: Cuesta
authors.forename: Jesús
authors.initials: J
authors.lastname: Martín Fernández
authors.forename: Justo M
authors.initials: JM
authors.lastname: Del-Alamo Rodríguez
authors.forename: Rosa A
authors.initials: RA
authors.lastname: Escriva Ferrairo
authors.forename: M
authors.initials: M
authors.lastname: Del Canto De-Hoyos Alonso
authors.forename: Laura Balsalobre
authors.initials: LB
authors.lastname: Arenas
authors.forename: Ricardo Rodríguez
authors.initials: RR
authors.lastname: Barrientos
authors.forename: Elisa Ceresuela
authors.initials: EC
authors.lastname: Wiesmann
authors.forename: Cristina
authors.initials: C
authors.lastname: De-Alba Romero
authors.forename: Yolanda Ginés
authors.initials: YG
authors.lastname: Díaz
authors.forename: Ana Pastor
authors.initials: AP
authors.lastname: Rodríguez-Moñino
authors.forename: Blanca Gutiérrez
authors.initials: BG
authors.lastname: Teira
authors.forename: Marta Sánchez-Celaya
authors.initials: MS
authors.lastname: Del Pozo
authors.forename: Jesús Fernández
authors.initials: JF
authors.lastname: Horcajuelo
authors.forename: María J
authors.initials: MJ
authors.lastname: Rojas Giraldo
authors.forename: Paulino Cubero
authors.initials: PC
authors.lastname: González
authors.forename: Rocío A
authors.initials: RA
authors.lastname: Vello Cuadrado
authors.forename: Beatriz López
authors.initials: BL
authors.lastname: Uriarte
authors.forename: Jeannet Sánchez
authors.initials: JS
authors.lastname: Yepes
authors.forename: Yolanda Hernando
authors.initials: YH
authors.lastname: Sanz
authors.forename: M José
authors.initials: MJ
authors.lastname: Iglesias Piñeiro
authors.forename: Susana Tudanca
authors.initials: ST
authors.lastname: Hernández
authors.forename: Fernando Gallardo
authors.initials: FG
authors.lastname: Alonso
authors.forename: Ana I
authors.initials: AI
authors.lastname: González González
authors.forename: Alicia Simón
authors.initials: AS
authors.lastname: Fernández
authors.forename: Carmen
authors.initials: C
authors.lastname: Carballo
authors.forename: Ana Rey
authors.initials: AR
authors.lastname: López
authors.forename: Fernanda
authors.initials: F
authors.lastname: Morales
authors.forename: Dolores
authors.initials: D
authors.lastname: Martínez López
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D057240:Patient Preference; D011320:Primary Health Care; D011446:Prospective Studies; D012449:Safety; D055815:Young Adult
chemical_list: D000935:Antifungal Agents