title: Cell migration regulates the kinetics of cytokinesis.
abstract: Cytokinesis is the final stage of cell division in which the daughter cells separate. Although a growing body of evidence suggests that cell migration-induced traction forces may be required to provide physical assistance for daughter cells to dissociate during abscission, the role of cell migration in cytokinesis has not been directly elucidated. Recently, we have demonstrated that Crk and paxillin, which are pivotal components of the cell migration machinery, localize to the midbody and are essential for the abscission. These findings provided an important link between the cell migration and cytokinesis machineries and prompted us to dissect the role of cell migration in cytokinesis. We show that cell migration controls the kinetics of cleavage furrowing, midbody extension and abscission and coordinates proper subcellular redistribution of Crk and syntaxin-2 to the midbody after ingression.
authors.affiliation: Department of Immunology, Rush University Medical Center; Chicago, IL USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Wood
authors.forename: Gayathri
authors.initials: G
authors.lastname: Sivaramakrishnan
authors.forename: Joanne
authors.initials: J
authors.lastname: Engel
authors.forename: Sasha H
authors.initials: SH
authors.lastname: Shafikhani
mesh_terms: D019138:Antibodies, Blocking / Q000276:immunology; D015153:Blotting, Western; D002455:Cell Division; D002465:Cell Movement; D048749:Cytokinesis; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006367:HeLa Cells; D006801:Humans; D019012:Integrin beta1 / Q000276:immunology; D007700:Kinetics; D051419:Paxillin / Q000378:metabolism; D050737:Proto-Oncogene Proteins c-crk / Q000378:metabolism; D050827:Syntaxin 1 / Q000378:metabolism
chemical_list: D019138:Antibodies, Blocking; D019012:Integrin beta1; D051419:Paxillin; D050737:Proto-Oncogene Proteins c-crk; D050827:Syntaxin 1