title: Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody.
abstract: This report describes, for the first time, an occurrence of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) in a 19-year-old female with neuromyelitis optica (NMO) spectrum disorder, who had anti-aquaporin-4 (AQP4) antibody. A high signal intensity lesion on T2-weighted MRI was detected in the midbrain tegmentum adjacent to the aqueduct, and presumably involved the medial longitudinal fasciculus bilaterally at the caudal levels. Plasma exchange resolved both WEBINO syndrome and the midbrain lesion. Although WEBINO syndrome is occasionally reported in multiple sclerosis patients, diagnosis of NMO should not be excluded in patients with WEBINO syndrome, because AQP4 is expressed abundantly around the periaqueductal region.
authors.affiliation: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Shinoda
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsushita
authors.forename: Konosuke
authors.initials: K
authors.lastname: Furuta
authors.forename: Noriko
authors.initials: N
authors.lastname: Isobe
authors.forename: Tomomi
authors.initials: T
authors.lastname: Yonekawa
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ohyagi
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kira
mesh_terms: D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D004172:Diplopia / Q000175:diagnosis / Q000276:immunology; D005099:Exotropia / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008636:Mesencephalon / Q000276:immunology / Q000473:pathology; D009471:Neuromyelitis Optica / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D009759:Nystagmus, Pathologic / Q000175:diagnosis / Q000276:immunology; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D010951:Plasma Exchange; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D007166:Immunosuppressive Agents