title: Two new amides with cytotoxic activity from the fruits of Piper longum.
abstract: Bioassay-guided fractionation of the fruits of Piper longum afforded two new minor amides, piperlongimin A (2) [2E-N-isobutyl-hexadecenamide] and piperlongimin B (4) [2E-octadecenoylpiperidine] together with five known compounds with moderate cytotoxic activity. The structures were elucidated on the basis of spectroscopic evidences. All these compounds inhibited cell proliferation of human leukemia, HL-60 cell lines, and displayed major apoptosis-inducing effects.
authors.affiliation: Department of Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Mishra
authors.forename: Sadhna
authors.initials: S
authors.lastname: Sinha
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Guru
authors.forename: Shashi
authors.initials: S
authors.lastname: Bhushan
authors.forename: R A
authors.initials: RA
authors.lastname: Vishwakarma
authors.forename: Sabari
authors.initials: S
authors.lastname: Ghosal
mesh_terms: D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D007194:India; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029222:Piper nigrum / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D010880:Piperidines; C556212:piperlongimin A; C556211:piperlongimin B