title: Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves--chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity.
abstract: Three extracts of different polarities of Glycyrrhiza glabra L. leaves were characterized and evaluated for their antioxidant, anti-genotoxic and anti-inflammatory activity. In total, thirty components have been identified and quantified through the use of liquid chromatography (LC) with ultraviolet-visible diode-array-detector (UV-vis-DAD) and mass spectrometry (MS). The main components belong to the polyphenols family, being flavonoid and dihydrostilbene derivatives. The extracts have been investigated for their antioxidant, anti-genotoxic and anti-inflammatory activities, which are fundamental requirements of efficacious chemo-preventive agents. The ethyl acetate extract proved to be the most valuable, evidently for the conspicuous presence of several polyphenols, namely flavonoids and dihydrostilbenes.
authors.affiliation: Istituto del C.N.R. di Chimica Biomolecolare, Via Paolo Gaifami, 18 I-95126 Catania, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Siracusa
authors.forename: Antonella
authors.initials: A
authors.lastname: Saija
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Cristani
authors.forename: Francesco
authors.initials: F
authors.lastname: Cimino
authors.forename: Manuela
authors.initials: M
authors.lastname: D'Arrigo
authors.forename: Domenico
authors.initials: D
authors.lastname: Trombetta
authors.forename: Felice
authors.initials: F
authors.lastname: Rao
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ruberto
mesh_terms: D000085:Acetates; D000893:Anti-Inflammatory Agents / Q000032:analysis*; D000975:Antioxidants / Q000032:analysis*; D001713:Biphenyl Compounds; D003124:Colorimetry; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006035:Glycyrrhiza / Q000737:chemistry*; D006586:Hexanes; D000432:Methanol; D008982:Molybdenum; D009152:Mutagenicity Tests; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D017973:Tungsten Compounds
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; C029556:Folin's phenol reagent; D006586:Hexanes; D010851:Picrates; D010936:Plant Extracts; D017973:Tungsten Compounds; C007650:ethyl acetate; D008982:Molybdenum; C004931:1,1-diphenyl-2-picrylhydrazyl; D000432:Methanol