title: Polyethylenimine-carbon nanotube nanohybrids for siRNA-mediated gene silencing at cellular level.
abstract: Carbon nanotubes (CNTs) covalently modified with low molecular weight polyethylenimine (PEI) are able to bind and deliver siRNA to cells with higher efficacy than a reference lipidic carrier. The performances of the nanohybrid are rationalized by the combination of the cell penetration and endosomal escape properties of CNTs and PEI, respectively.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191, Gif-sur-Yvette, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Foillard
authors.forename: Guy
authors.initials: G
authors.lastname: Zuber
authors.forename: Eric
authors.initials: E
authors.lastname: Doris
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry*; D004058:Diffusion; D020868:Gene Silencing; D006801:Humans; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011094:Polyethyleneimine / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000235:genetics*
chemical_list: D053769:Nanocapsules; D037742:Nanotubes, Carbon; D034741:RNA, Small Interfering; D011094:Polyethyleneimine