title: Brain injury after intracerebral hemorrhage in spontaneously hypertensive rats.
abstract: OBJECTIVE
  Hypertension is the main cause of spontaneous intracerebral hemorrhages (ICHs), but the effects of hypertension on ICH-induced brain injury have not been well studied. In this study, the authors examined ICH-induced brain injury in spontaneously hypertensive rats (SHRs).
  
  
  METHODS
  This 2-part study was performed in 12-week-old male SHRs and Wistar Kyoto (WKY) rats. First, the rats received an intracaudate injection of 0.3 U collagenase, and hematoma sizes were determined at 24 hours. Second, rats were injected with 100 μl autologous whole blood into the right basal ganglia. Brain edema, neuronal death, ferritin expression, microglia activation, and neurological deficits were examined.
  
  
  RESULTS
  Hematoma sizes were the same in SHR and WKY rats 24 hours after collagenase injection. The SHRs had greater neuronal death and neurological deficits after blood injection. Intracerebral hemorrhage also resulted in higher brain ferritin levels and stronger activation of microglia in SHRs. However, perihematomal brain edema was the same in the SHRs and WKY rats.
  
  
  CONCLUSIONS
  Moderate chronic hypertension resulted in more severe ICH-induced neuronal death and neurological deficits, but did not exaggerate hematoma enlargement and perihematomal brain edema in the rat ICH models.
authors.affiliation: Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109-2200, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Xuhui
authors.initials: X
authors.lastname: Bao
authors.forename: Guohua
authors.initials: G
authors.lastname: Xi
authors.forename: Richard F
authors.initials: RF
authors.lastname: Keep
authors.forename: B Gregory
authors.initials: BG
authors.lastname: Thompson
authors.forename: Ya
authors.initials: Y
authors.lastname: Hua
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism; D001930:Brain Injuries / Q000209:etiology* / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000378:metabolism; D004195:Disease Models, Animal; D005293:Ferritins / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D005293:Ferritins