title: [Animal models for bone and joint disease. Rodent models of natural aging].
abstract: This review summarizes changes in bone mass and metabolism during natural aging of C57BL/6J mice and F344/N rats, as models of senile osteoporosis. The effects of caloric restriction, an evolutionally conserved remedy known to slow aging process and counter age-related disorders, on bone metabolism are also discussed.
authors.affiliation: National Center for Geriatrics and Gerontology (NCGG).
authors.forename: Kyoji
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D031204:Caloric Restriction; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344