title: Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice.
abstract: Chelerythrine (CHE), a quaternary benzo[c]phenanthridine alkaloid, which is an agent in traditional Chinese medicine exhibits a wide spectrum of pharmacological effects. In this study, we examined the anti-inflammatory activities and mechanism of CHE in vivo and in vitro, respectively. Further, in the analgesic test, CHE also showed pronounced inhibition of the acetic acid-induced writhing response. These results clearly suggested that CHE is a bioactive agent which has a significant anti-inflammatory action, which may be relevant to the inhibition of the release/production of exudates and prostaglandin E(2) mediated through cyclooxygenase-2 regulation.
authors.affiliation: School of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Niu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Li
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Xu
mesh_terms: D019342:Acetic Acid; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D053119:Benzophenanthridines / Q000494:pharmacology / Q000627:therapeutic use*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy*; D005260:Female; D005557:Formaldehyde; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D010147:Pain Measurement; D014992:Xylenes
chemical_list: D000893:Anti-Inflammatory Agents; D053119:Benzophenanthridines; D052246:Cyclooxygenase 2 Inhibitors; D004365:Drugs, Chinese Herbal; D014992:Xylenes; D005557:Formaldehyde; C016299:chelerythrine; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D015232:Dinoprostone; D019342:Acetic Acid