title: Human insulin allergy: four case reports.
abstract: Insulin allergy was not uncommon in the past, but has lowered with the introduction of human recombinant insulin. Human recombinant insulin allergy is a rare condition, now reported in less than 1% of treated patients. However, it is a serious condition that requires an immediate allergological work-up. In this study, we describe 4 cases of IgE-mediated reaction to human recombinant insulin, emphasizing some practical aspects in diagnosis and treatment.
authors.affiliation: Clinical Immunology and Allergy Service, Department of Internal Medicine, Hospital das Clínicas, University of São Paulo, Brazil. lfensina@yahoo.com.br
authors.forename: A
authors.initials: A
authors.lastname: Teixeira Rodrigues
authors.forename: L F Chiaverini
authors.initials: LF
authors.lastname: Ensina
authors.forename: L
authors.initials: L
authors.lastname: Sabino Garro
authors.forename: L
authors.initials: L
authors.lastname: Kase Tanno
authors.forename: P
authors.initials: P
authors.lastname: Giavina-Bianchi
authors.forename: A Abilio
authors.initials: AA
authors.lastname: Motta
mesh_terms: D000368:Aged; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007328:Insulin / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects
chemical_list: D007328:Insulin; D011994:Recombinant Proteins; D007073:Immunoglobulin E