title: Systemic nocardiosis caused by Nocardia concava in China.
abstract: A 42-year-old man with polychondritis and a 2-year history of using low-dose prednisone and other immunosuppressive drugs was admitted to our hospital due to persistent high fever of 10 days duration. A strain of Nocardia was twice isolated from his blood and subsequently identified to be N. concava. The patient was initially treated with sulphadiazine sodium, vancomycin and imipenema for 7 days but the symptoms persisted. Consequently, the regimen was changed to sulphadiazine sodium, ciprofloxacin and amikacin sulfate based on the antibiotic susceptibility tests of the Nocardia isolate. The fever disappeared and the patient's condition improved after 10 days of this treatment to the extent that he was discharged. However, 7 days later, the patient's condition deteriorated and he died due to multiple organ failure. This is the first report of N. concava causing systemic nocardiosis in China.
authors.affiliation: Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yongxuan
authors.initials: Y
authors.lastname: Hu
authors.forename: Donghui
authors.initials: D
authors.lastname: Zheng
authors.forename: Kayoko
authors.initials: K
authors.lastname: Takizawa
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Mikami
authors.forename: Lie
authors.initials: L
authors.lastname: Dai
authors.forename: Katsukiyo
authors.initials: K
authors.lastname: Yazawa
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Fukushima
authors.forename: Changming
authors.initials: C
authors.lastname: Lu
authors.forename: Liyan
authors.initials: L
authors.lastname: Xi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016470:Bacteremia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D015373:Bacterial Typing Techniques; D001769:Blood / Q000382:microbiology; D002681:China; D027081:DNA Gyrase / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D017809:Fatal Outcome; D006651:Histocytochemistry; D006801:Humans; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009102:Multiple Organ Failure; D009615:Nocardia / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D010802:Phylogeny; D011860:Radiography, Abdominal; D013902:Radiography, Thoracic; D017422:Sequence Analysis, DNA; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D027081:DNA Gyrase