title: Derivation of developmentally competent oocytes by in vitro culture of preantral follicles retrieved from aged mice.
abstract: Mature oocytes were derived from cultured preantral follicles retrieved from aged (63-67 weeks old) mice with decreased fecundity; IVF of the oocytes resulted in cleaving embryos. There was no difference in developmental competence of 4-cell embryos to the blastocyst stage between the adult and the aged groups, although general retardation of follicle development and oocyte maturation and development after IVF was detected.
authors.affiliation: Department of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
authors.forename: Jung Kyu
authors.initials: JK
authors.lastname: Choi
authors.forename: Jong Il
authors.initials: JI
authors.lastname: Ahn
authors.forename: Jong Heum
authors.initials: JH
authors.lastname: Park
authors.forename: Jeong Mook
authors.initials: JM
authors.lastname: Lim
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009866:Oogenesis / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology* / Q000502:physiology*; D011897:Random Allocation