title: Comparison of retinal thickness values and segmentation performance of different OCT devices in acute branch retinal vein occlusion.
abstract: OBJECTIVE
  To compare retinal thickness (RT) measurement and segmentation performance of time domain (TD, Stratus) and spectral domain (SD) optical coherence tomography (OCT) devices (Cirrus, Spectralis) for imaging macular oedema (ME) secondary to branch retinal vein occlusion (BRVO).
  
  
  METHODS
  In this study, 20 eyes of 20 consecutive patients with acute BRVO were included. A total of 18 unaffected fellow eyes served as control group. RT measurement was analysed in the five inner fields of the early-treatment diabetic retinopathy grid, and proportional segmentation errors were evaluated.
  
  
  RESULTS
  Central millimetre thickness (CMT) showed a mean difference of -64, -74, and -18 μm (P < 0.001) in the control group and -31 μm (P=0.107), -92 μm (P<0.001), and -105 μm (P=0.016) in the BRVO group, between Stratus and Cirrus, between Stratus and Spectralis, and between Cirrus and Spectralis, respectively. Mean RT showed the highest variability between different devices in the area most intensively affected by BRVO-related ME. In eyes with BRVO, 14.6% of Spectralis, 20% of Stratus, and 36.6% of Cirrus scans demonstrated moderate and severe segmentation errors.
  
  
  CONCLUSIONS
  RT measurement in eyes with BRVO, by TD and SD OCT, is compromised by a significant rate of segmentation errors. Deviations are most pronounced in the areas most severely affected by ME.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Matt
authors.forename: S
authors.initials: S
authors.lastname: Sacu
authors.forename: W
authors.initials: W
authors.lastname: Buehl
authors.forename: C
authors.initials: C
authors.lastname: Ahlers
authors.forename: R
authors.initials: R
authors.lastname: Dunavoelgyi
authors.forename: C
authors.initials: C
authors.lastname: Pruente
authors.forename: U
authors.initials: U
authors.lastname: Schmidt-Erfurth
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology*; D012170:Retinal Vein Occlusion / Q000150:complications*; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000592:standards