title: A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites.
abstract: Population subgroups of the African malaria vector Anopheles gambiae have not been comprehensively characterized owing to the lack of unbiased sampling methods. In the arid savanna zone of West Africa, where potential oviposition sites are scarce, widespread collection from larval pools in the peridomestic human habitat yielded a comprehensive genetic survey of local A. gambiae population subgroups, independent of adult resting behavior and ecological preference. A previously unknown subgroup of exophilic A. gambiae is sympatric with the known endophilic A. gambiae in this region. The exophilic subgroup is abundant, lacks differentiation into M and S molecular forms, and is highly susceptible to infection with wild Plasmodium falciparum. These findings might have implications for the epidemiology of malaria transmission and control.
authors.affiliation: Institut Pasteur, Unit of Insect Vector Genetics and Genomics, Department of Parasitology and Mycology, 28 rue du Docteur Roux, Paris 75015, France.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Riehle
authors.forename: Wamdaogo M
authors.initials: WM
authors.lastname: Guelbeogo
authors.forename: Awa
authors.initials: A
authors.lastname: Gneme
authors.forename: Karin
authors.initials: K
authors.lastname: Eiglmeier
authors.forename: Inge
authors.initials: I
authors.lastname: Holm
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bischoff
authors.forename: Thierry
authors.initials: T
authors.lastname: Garnier
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Snyder
authors.forename: Xuanzhong
authors.initials: X
authors.lastname: Li
authors.forename: Kyriacos
authors.initials: K
authors.lastname: Markianos
authors.forename: N'Fale
authors.initials: N
authors.lastname: Sagnon
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Vernick
mesh_terms: D000818:Animals; D000852:Anopheles / Q000145:classification / Q000235:genetics* / Q000469:parasitology* / Q000502:physiology; D001499:Bayes Theorem; D002050:Burkina Faso / Q000453:epidemiology; D005838:Genotype; D006790:Host-Parasite Interactions; D006798:Housing; D006801:Humans; D006824:Hybridization, Genetic; D007303:Insect Vectors / Q000235:genetics* / Q000469:parasitology* / Q000502:physiology; D007814:Larva / Q000235:genetics / Q000469:parasitology / Q000502:physiology; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D018895:Microsatellite Repeats; D009032:Mosquito Control; D010963:Plasmodium falciparum / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D011157:Population Dynamics