title: Induction of adaptive response: pre-exposure of mice to 900 MHz radiofrequency fields reduces hematopoietic damage caused by subsequent exposure to ionising radiation.
abstract: OBJECTIVE
  To investigate whether an adaptive response can be induced in mice which were pre-exposed to 900 MHz radiofrequency fields.
  
  
  METHODS
  Adult male Kunming mice were exposed to 900 MHz radiofrequency fields (RF) at power intensities of 12, 120 and 1200 μW/cm(2) for 1 h/day for 14 days and then subjected to whole body gamma-irradiation. The results were compared with those in unexposed control animals and those exposed to gamma-irradiation alone (without pre-exposure to RF). The extent of survival and hematopoietic tissue damage (assessed in the form of nucleated colony forming cells in the bone marrow and colony forming cells in the spleen of lethally irradiated 'recipient' mice) as well as the expression of cell cycle-related genes were investigated.
  
  
  RESULTS
  The results indicated a significant increase in survival time, reduction in the hematopoietic tissue damage in RF pre-exposed mice which were gamma-irradiated (as compared with those exposed to gamma-radiation alone). This was accompanied by significantly increased expression of cell cycle-related genes, namely, cyclin-D1, cyclin-E, cyclin-DK4 and cyclin-DK2 in hematopoietic cells.
  
  
  CONCLUSIONS
  Pre-exposure of mice to 900 MHz radiofrequency fields has resulted in a significant reduction in hematopoietic damage caused by subsequent exposure to ionising radiation. This phenomenon appears to be similar to that of the 'adaptive response' which is well documented in scientific literature.
authors.affiliation: School of Radiation Medicine and Public Health, Soochow University, Suzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Zong-Da
authors.initials: ZD
authors.lastname: Jin
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou
authors.forename: Ji-Hua
authors.initials: JH
authors.lastname: Nie
authors.forename: Jian
authors.initials: J
authors.lastname: Tong
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology* / Q000528:radiation effects*; D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000502:physiology* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000502:physiology* / Q000528:radiation effects*; D014916:Whole-Body Irradiation