title: Impaired fasting glucose association with mortality in nondiabetic patients on maintenance peritoneal dialysis.
abstract: BACKGROUND
  The aim of this study was to investigate clinical significance of impaired fasting glucose (IFG) in nondiabetic patients on maintenance peritoneal dialysis (PD).
  
  
  METHODS
  In total, 362 maintenance PD patients were enrolled and followed up for 2-years. According to 1997 definitions, patients were divided into 3 groups: diabetic (n = 85), nondiabetic with IFG (n = 62) and nondiabetic with normal fasting glucose levels (n = 215). After basal data were collected for cross-sectional analyses, mortality and cause of death were recorded for longitudinal analyses.
  
  
  RESULTS
  After adjusting for related variables by multivariate logistic regression analysis, IFG was found to be positively associated with age but negatively associated with normalized protein nitrogen appearance and transferrin saturation in nondiabetic maintenance PD patients. Thirty nondiabetic patients had died after the 2-year follow-up. Cox multivariate analysis showed that age (hazard ratio: 1.037; 95% confidence interval: 1.002-1.073; P = 0.036) and presence of IFG (hazard ratio: 2.719; 95% confidence interval: 1.082-6.833; P = 0.033) were significant risk factors for all-cause 2-year mortality in nondiabetic maintenance PD patients.
  
  
  CONCLUSIONS
  IFG, a preventable and treatable condition, was associated with all-cause 2-year mortality in nondiabetic maintenance PD patients.
authors.affiliation: Division of Clinical Toxicology, Department of Nephrology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Taipei, Taiwan. guanhsing@yahoo.com.tw
authors.forename: Kuan-Hsing
authors.initials: KH
authors.lastname: Chen
authors.forename: Ja-Liang
authors.initials: JL
authors.lastname: Lin
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Hung
authors.forename: Dan-Tzu
authors.initials: DT
authors.lastname: Lin-Tan
authors.forename: Shu-Man
authors.initials: SM
authors.lastname: Weng
authors.forename: Tzung-Hai
authors.initials: TH
authors.lastname: Yen
authors.forename: Ching-Wei
authors.initials: CW
authors.lastname: Hsu
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005215:Fasting / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology* / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000401:mortality* / Q000628:therapy*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009584:Nitrogen / Q000378:metabolism; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D014168:Transferrin / Q000378:metabolism; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014168:Transferrin; D009584:Nitrogen