title: Inhibitory effect of (E)-1,2-di(3,5-dimethoxyphenyl)ethene on 3T3-L1 adiopocyte differentiation.
abstract: Resveratrol (trans-3,5,4'-trihydroxystilbene) is a phytoalexin found in diverse plant species, including grapes and peanuts. The antioxidant, anticancer, and cardioprotective properties of resveratrol have been well-characterized. The anti-obesity effect of resveratrol has also been demonstrated in previous studies. In this study, we evaluated the effects of a resveratrol analogue, (E)-1,2-di(3,5-dimethoxyphenyl)ethene, on adipocyte differentiation using 3T3-L1 cells. According to our results, the tested analogue potently inhibits the differentiation of 3T3-L1 adipocyte to a greater degree than resveratrol. Moreover, (E)-1,2-di(3,5-dimethoxyphenyl)ethene strongly downregulated the expression of fatty acid metabolism-related proteins such as fatty acid synthase and acetyl-CoA carboxylase. These results point to the potential of (E)-1,2-di(3,5-dimethoxyphenyl)ethene as an obesity prevention agent.
authors.affiliation: Korea Food Research Institute, Seongnam, Korea.
authors.forename: Jin Taek
authors.initials: JT
authors.lastname: Hwang
authors.forename: Sanghee
authors.initials: S
authors.lastname: Kim
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Choi
mesh_terms: D041721:3T3-L1 Cells; D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors; D017667:Adipocytes / Q000187:drug effects*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors; D005227:Fatty Acids / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D000077185:Resveratrol; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C444340:1-(2,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethene; D005227:Fatty Acids; D013267:Stilbenes; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase; D000077185:Resveratrol