title: The same chromosome 9p21.3 locus is associated with type 2 diabetes and coronary artery disease in a Chinese Han population.
abstract: OBJECTIVE
  Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out a large-scale case-control study in the GeneID Chinese Han population to 1) further replicate the association of 9p21.3 type 2 diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess the association of these SNPs with coronary artery disease.
  
  
  METHODS
  Three SNPs (rs2383208, rs10811661, and rs10757283) were genotyped in two GeneID cohorts of 3,167 Chinese Han individuals. Case-control association design was used to determine the association of the SNPs with type 2 diabetes and coronary artery disease. Gensini scores were calculated in the coronary artery disease subjects and were tested for association with the variants. Multivariate logistic regressions were performed on association studies.
  
  
  RESULTS
  The association between two of the three SNPs and type 2 diabetes was replicated in the GeneID population (rs2383208, P = 0.936; rs10811661-T, P = 0.02, odds ratio [OR] = 1.23; rs10757283-C, P = 0.003, OR = 1.30). The same two SNPs also contributed to the risk of coronary artery disease (CAD) (rs10811661-T, P = 0.002, OR = 1.19; rs10757283-C, P = 0.003, OR = 1.18). In addition, rs10757283 was associated with severity of coronary atherosclerosis estimated by the Gensini scoring system (risk allele C, quantitative-trait regression adjusted P = 0.002).
  
  
  CONCLUSIONS
  For the first time to our knowledge, our results indicated that the same 9p21.3 locus, represented by SNPs rs10811661 and rs10757283, contributed to the risk of type 2 diabetes and coronary artery disease in our GeneID Chinese Han population.
authors.affiliation: Institute of Cardiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Cheng
authors.forename: Lisong
authors.initials: L
authors.lastname: Shi
authors.forename: Shaofang
authors.initials: S
authors.lastname: Nie
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Li
authors.forename: Chengqi
authors.initials: C
authors.lastname: Xu
authors.forename: Pengyun
authors.initials: P
authors.lastname: Wang
authors.forename: Baofeng
authors.initials: B
authors.lastname: Yang
authors.forename: Qingxian
authors.initials: Q
authors.lastname: Li
authors.forename: Zhenwei
authors.initials: Z
authors.lastname: Pan
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Xia
authors.forename: Chenhong
authors.initials: C
authors.lastname: Zheng
authors.forename: Yuhe
authors.initials: Y
authors.lastname: Ke
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Wu
authors.forename: Tingting
authors.initials: T
authors.lastname: Tang
authors.forename: Xinxin
authors.initials: X
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Ni
authors.initials: N
authors.lastname: Xia
authors.forename: Rui
authors.initials: R
authors.lastname: Yao
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.forename: Qiutang
authors.initials: Q
authors.lastname: Zeng
authors.forename: Xin
authors.initials: X
authors.lastname: Tu
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Liao
authors.forename: Qing K
authors.initials: QK
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide