title: Cu-catalyzed one-pot synthesis of unsymmetrical diaryl thioethers by coupling of aryl halides using a thiol precursor.
abstract: An efficient Cu-catalyzed one-pot approach for the synthesis of unsymmetrical diaryl thioethers using potassium ethyl xanthogenate as a thiol surrogate is developed. This new protocol avoids usage of intricate thiols and makes use of its easily available xanthate as a precursor, and thiol will be generated in situ to prepare the diaryl thioethers through a Cu-catalyzed double arylation. This strategy was further successfully utilized for the synthesis of symmetrical diaryl thioethers, aryl alkyl thioethers, and benzothiazoles.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
authors.forename: D J C
authors.initials: DJ
authors.lastname: Prasad
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Sekar
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry; D013871:Thiones / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D013438:Sulfhydryl Compounds; D013440:Sulfides; D013871:Thiones; D003300:Copper; C004918:ethylxanthate