title: Role of methylenetetrahydrofolate reductase gene (MTHFR) 677C>T polymorphism in pediatric cerebrovascular disorders.
abstract: Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) 677C>T mutation (MTHFR TT) has been linked to an increased risk for stroke, coronary artery disease, and migraine headaches. The authors analyzed the potential link between MTHFR 677C>T homozygosity and childhood stroke. A true association might facilitate screening, recurrence risk stratification, and treatment in patients with cerebrovascular disease. They performed a retrospective chart review of children tested for the MTHFR 677C>/T mutation; 533 patients underwent MTHFR testing, and 8% were homozygous for the MTHFR 677C>T mutation. There was no difference in the cohort compared with the prevalence in the general population. This suggests that the MTHFR 677 C>T polymorphism played a minimal role or no role in stroke risk. However, the data suggest that the MTHFR TT genotype may influence migraine susceptibility in children because there was a higher proportion of migraine patients (28.6%) with the MTHFR TT homozygous genotype.
authors.affiliation: Division of Child Neurology, The Ohio State University, Columbus, Nationwide Children's Hospital, OH 43205, USA.
authors.forename: Hamza
authors.initials: H
authors.lastname: Alsayouf
authors.forename: Khaled M
authors.initials: KM
authors.lastname: Zamel
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Heyer
authors.forename: A Latif
authors.initials: AL
authors.lastname: Khuhro
authors.forename: Samir B
authors.initials: SB
authors.lastname: Kahwash
authors.forename: Emily C
authors.initials: EC
authors.lastname: de los Reyes
mesh_terms: D000293:Adolescent; D002561:Cerebrovascular Disorders / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D010372:Pediatrics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)