title: Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages?
abstract: Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis represent a major challenge to clinicians and immunologists trying to understand why in certain individuals the peaceful coexistence of the commensal microflora and its host breaks down and results in chronic inflammation. Here we summarize the recent progress in our understanding of the organization of the intestinal mononuclear phagocytes with dendritic cells and macrophages of distinct phenotype, origin and function. Finally, we discuss potential strategies to translate the recent findings into the management of chronic inflammation in animal models of IBD.
authors.affiliation: Department of Immunology, Weizmann Institute of Science, Herzl 1, Rehovot, Israel.
authors.forename: Liat
authors.initials: L
authors.lastname: Bar-On
authors.forename: Ehud
authors.initials: E
authors.lastname: Zigmond
authors.forename: Steffen
authors.initials: S
authors.lastname: Jung
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000628:therapy*; D007422:Intestines / Q000166:cytology* / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D013154:Spleen / Q000276:immunology