title: Changes in cerebral hemodynamics after carotid stenting of symptomatic carotid artery.
abstract: OBJECTIVE
  To evaluate changes in cerebral hemodynamics after carotid stenting of symptomatic carotid artery in the patients who underwent ischemic stroke caused by carotid artery stenosis.
  
  
  METHODS
  Twenty patients with unilateral symptomatic carotid artery stenosis received brain computer tomography perfusion (CTP) scan a week before and a week after carotid artery stenting. Three absolute values including mean transit time (MTT), cerebral blood volume (CBV), and cerebral blood flow (CBF) were acquired and analyzed by use of the post-processing software. Six vascular territories such as ACA territory, MCA territory, PCA territory, basal ganglia, watershed between ACA and MCA territory (frontal watershed), watershed between MCA and PCA territory (posterior watershed) were chosen for comparison. Relative parameter values were defined as rCBF (relative CBF), rCBV (relative CBV), rMTT (relative MTT) through comparing absolute values in symptomatic hemispheres to absolute values in asymptomatic hemispheres. The relative perfusion parameter values before treatment were compared with post-treatment values. These analyses were performed by using the paired t test.
  
  
  RESULTS
  The mean rMTT decreased significantly in ACA territory, MCA territory and two watershed after treatment, while the mean rCBF increased significantly in those areas after treatment. But the mean rCBV had no significant changes in all six vascular territories. In PCA territory, all the parameters had no significant changes.
  
  
  CONCLUSIONS
  Carotid artery stenting yields satisfactory cerebral perfusion in ACA territory, MCA territory, basal ganglia and two watersheds.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Wenzhou Medical College. No.2 Fuxue Lane, Wenzhou City, ZheJiang Province, 325000, PR China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Duan
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Yunjun
authors.initials: Y
authors.lastname: Yang
authors.forename: Jiance
authors.initials: J
authors.lastname: Li
authors.forename: Haibo
authors.initials: H
authors.lastname: Huang
authors.forename: Hongqing
authors.initials: H
authors.lastname: Wang
authors.forename: Fanghong
authors.initials: F
authors.lastname: Xu
authors.forename: Weijian
authors.initials: W
authors.lastname: Chen
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D015607:Stents; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome