title: Toxic effect of terbium ion on horseradish cell.
abstract: The toxic effect of terbium (III) ion on the horseradish cell was investigated by scanning electron microscopy, gas chromatography, and standard biochemical methods. It was found that the activity of horseradish peroxidase in the horseradish treated with 0.2 mM terbium (III) ion decreased and led to the excessive accumulation of free radicals compared with that in the control horseradish. The excessive free radicals could oxidize unsaturated fatty acids in the horseradish cell and then increase the cell membrane lipid peroxidation of horseradish. The increase in the lipid peroxidation could lead to the destruction of the structure and function of the cell membrane and then damage of the horseradish cell. We propose that this is a possible mechanism for the toxic action of terbium in the biological systems.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing, 210097, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Jiang
authors.forename: Lihong
authors.initials: L
authors.lastname: Wang
authors.forename: Tianhong
authors.initials: T
authors.lastname: Lu
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Huang
mesh_terms: D031215:Armoracia / Q000187:drug effects* / Q000201:enzymology; D002849:Chromatography, Gas; D005609:Free Radicals / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation; D008855:Microscopy, Electron, Scanning; D013725:Terbium / Q000633:toxicity*
chemical_list: D005609:Free Radicals; D013725:Terbium; D006735:Horseradish Peroxidase