title: Differences in rat models used in routine toxicity studies.
abstract: The discussion on whether the Sprague Dawley (SD), the Fischer F344, or the Hannover Wistar rat is the most appropriate model for toxicity studies in rodents is ongoing. A substantial quantity of data on these strains concerning their source, diet, and housing conditions have been published. Generally, before starting a toxicology program in rodents, it should be taken into account that oncogenicity studies will be required for the majority of compounds successfully completing development. Survival, body weight development, incidence, type, time of onset of age-dependent lesions and neoplasms, as well as some special considerations of the rat model selected may be decisive. Therefore, an understanding of the historical background data is essential. These aspects demonstrate why the use of a specific rat model should be carefully considered at the beginning of the toxicology program.
authors.affiliation: AnaPath GmbH, Buchsweg 56, 4625 Oberbuchsiten, Switzerland. kweber@harlan.com
authors.forename: Klaus
authors.initials: K
authors.lastname: Weber
authors.forename: Tanja
authors.initials: T
authors.lastname: Razinger
authors.forename: Jerry F
authors.initials: JF
authors.lastname: Hardisty
authors.forename: Peter
authors.initials: P
authors.lastname: Mann
authors.forename: Kellie C
authors.initials: KC
authors.lastname: Martel
authors.forename: Emily A
authors.initials: EA
authors.lastname: Frische
authors.forename: Kai
authors.initials: K
authors.lastname: Blumbach
authors.forename: Stephen
authors.initials: S
authors.lastname: Hillen
authors.forename: SeungWoo
authors.initials: S
authors.lastname: Song
authors.forename: Takayuki
authors.initials: T
authors.lastname: Anzai
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Chevalier
mesh_terms: D000818:Animals; D001835:Body Weight; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity; D005260:Female; D008297:Male; D023421:Models, Animal; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D009929:Organ Size; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D002273:Carcinogens