title: Dendritic cells in alcoholic liver injury and fibrosis.
abstract: Alcohol consumption impairs the development of innate and adaptive immune responses, however the exact mechanism by which alcohol leads to immune defects remains to be established. Dendritic cells (DCs) form a heterogeneous population of hematopoietic cells that are present in all tissues including the liver. DC are initially described playing a key role in the induction of innate and adaptive immune response against specific antigens. In our presentation, we discussed few new aspects of DC development, critical assessment of DC in non-lymphoid organs and the impact of alcohol consumption on DC function. Understanding the mechanism by which DC modulate liver function after alcohol consumption may help uncover novel therapeutic strategies for the treatment of these conditions.
authors.affiliation: Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. costica.aloman@mssm.edu
authors.forename: Costica
authors.initials: C
authors.lastname: Aloman
authors.forename: Scott L
authors.initials: SL
authors.lastname: Friedman
authors.forename: Miriam
authors.initials: M
authors.lastname: Merad
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000428:Alcohol Drinking / Q000009:adverse effects / Q000276:immunology*; D000437:Alcoholism / Q000150:complications / Q000276:immunology; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000276:immunology*