title: Proventricular dilatation disease associated with avian bornavirus infection in a Citron-crested Cockatoo that was born and hand-reared in Japan.
abstract: A 5-month-old female Citron-crested Cockatoo (Cacatua sulphurea citrinocristata) that was born and hand-reared in Japan died with suspected proventricular dilatation disease (PDD). Macroscopic and microscopic examinations of the bird revealed characteristic features of PDD, i.e., distention of the proventriculus and infiltration of lymphocytes and plasma cells in ganglia of various organs and in central and peripheral nerves. A linkage of this PDD case to infection with avian bornavirus (ABV) was documented by RT-PCR amplification of the virus genomes from the affected bird. Phylogenetic analysis revealed that the ABV identified in this study clustered into the genotype 2, which is one of the dominant ABV genotypes worldwide. To the best of our knowledge, this is the first report of a natural case of PDD associated with ABV infection in Japan.
authors.affiliation: Nippon Institute for Biological Science, Ome, Tokyo 198–0024, Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Ogawa
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sanada
authors.forename: Naoko
authors.initials: N
authors.lastname: Sanada
authors.forename: Megumi
authors.initials: M
authors.lastname: Kudo
authors.forename: Kotaro
authors.initials: K
authors.lastname: Tuchiya
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kodama
authors.forename: Koji
authors.initials: K
authors.lastname: Uetsuka
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001715:Bird Diseases / Q000473:pathology* / Q000821:virology*; D028981:Bornaviridae / Q000235:genetics / Q000302:isolation & purification*; D046410:Cockatoos; D004108:Dilatation, Pathologic / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D007564:Japan; D008969:Molecular Sequence Data; D018701:Mononegavirales Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D011531:Proventriculus / Q000473:pathology* / Q000821:virology; D012329:RNA, Bacterial / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D016415:Sequence Alignment
chemical_list: D012329:RNA, Bacterial