title: Primary peripheral PNET/Ewing's sarcoma arising in the meninges, confirmed by the presence of the rare translocation t(21;22) (q22;q12).
abstract: Peripheral primitive neuroectodermal tumor/Ewing's sarcoma (ES) (pPNET/ES) of intracranial origin are very rare. These tumors are characterized by specific translocations involving a gene on chromosome 22q12, the most common being t(11;22) (q24;q12). We report a case of 37-year-old man with pPNET/ES arising in the meninges and bearing the rare translocation t(21;22) (q22;q12). The tumor was composed of sheets and nests of monotonous small cells with round to oval nuclei, finely dispersed chromatin, small nucleolus and scant cytoplasm. We discuss the importance of the differential diagnosis with central primitive neuroectodermal tumors (cPNET).
authors.affiliation: Department of Radiological, Pathological and Oncological Sciences, Sapienza University, Rome, Italy. manila_antonelli@yahoo.it
authors.forename: Manila
authors.initials: M
authors.lastname: Antonelli
authors.forename: Rosario
authors.initials: R
authors.lastname: Caltabiano
authors.forename: Caterina
authors.initials: C
authors.lastname: Chiappetta
authors.forename: Maria A
authors.initials: MA
authors.lastname: Oliva
authors.forename: Felice
authors.initials: F
authors.lastname: Giangaspero
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lanzafame
mesh_terms: D000328:Adult; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis / Q000235:genetics*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*