title: Peripheral somatosensation: a touch of genetics.
abstract: The somatosensory system processes information that organisms 'feel': joint position, muscle stretch, pain, pressure, temperature, and touch. The system is composed of a diverse array of peripheral nerve endings specialized to detect these sensory modalities. Several recent discoveries have shed light on the genetic pathways that control specification and differentiation of these neurons, how they accurately innervate their central and peripheral targets, and the molecules that enable them to detect mechanical stimuli. Here, we review the cadre of genes that control these processes, focusing on mechanosensitive neurons and support cells of the skin that mediate different aspects of the sense of touch.
authors.affiliation: Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, United States.
authors.forename: Erin G
authors.initials: EG
authors.lastname: Reed-Geaghan
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Maricich
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000235:genetics; D053263:Gene Regulatory Networks / Q000235:genetics; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000235:genetics*; D018862:Merkel Cells / Q000502:physiology; D051379:Mice; D009457:Neuroglia / Q000502:physiology; D010146:Pain / Q000235:genetics; D017933:Peripheral Nervous System / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000502:physiology*; D014110:Touch / Q000235:genetics*