title: Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis.
abstract: TiO₂ films may be used to alter the wettability and hemocompatibility of cellulose materials. In this study, pure and stoichiometric TiO₂ films were grown using atomic layer deposition on both silicon and cellulose substrates. The films were grown with uniform thicknesses and with a growth rate in agreement with literature results. The TiO₂ films were shown to profoundly alter the water contact angle values of cellulose in a manner dependent upon processing characteristics. Higher amounts of protein adsorption indicated by blurry areas on images generated by scanning electron microscopy were noted on TiO₂ -coated cellulose acetate than on uncoated cellulose acetate. These results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials.
authors.affiliation: Department of Chemical and Bimolecular Engineering, North Carolina State University, Raleigh, NC, USA.
authors.forename: G Kevin
authors.initials: GK
authors.lastname: Hyde
authors.forename: S Michael
authors.initials: SM
authors.lastname: Stewart
authors.forename: Giovanna
authors.initials: G
authors.lastname: Scarel
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Parsons
authors.forename: Chun-Che
authors.initials: CC
authors.lastname: Shih
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Shih
authors.forename: Shing-Jong
authors.initials: SJ
authors.lastname: Lin
authors.forename: Yea-Yang
authors.initials: YY
authors.lastname: Su
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Monteiro-Riviere
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Narayan
mesh_terms: D002470:Cell Survival / Q000502:physiology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D053657:Platelet-Rich Plasma / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D014025:Titanium / Q000737:chemistry*; D017155:Wettability
chemical_list: C009495:titanium dioxide; C005062:acetylcellulose; D002482:Cellulose; D014025:Titanium