title: [hTERT single nucleotide polymorphism is associated with increased risks of hepatocellular carcinoma and tumor metastasis].
abstract: OBJECTIVE
  To investigate the effect of hTERT single nucleotide polymorphisms on the development and metastasis of hepatocellular carcinoma.
  
  
  METHODS
  A total of 290 male patients were divided into hepatitis-induced primary hepatocellular carcinoma (HCC) group (n%162), metastatic HCC group (n%22), and control group (n%106). hTERT gene was amplified and hTERT single nucleotide polymorphisms (SNPs) were tested in these subjects.
  
  
  RESULTS
  Significant differences were found in rs2853690 and rs10069690 distribution, but the difference in rs6554743 remained uncertain. The C and T alleles of rs10069690 and rs6554743 showed significant differences between the 3 groups; the carriers of non-T allele of rs10069690 had higher frequencies in both primary and metastatic HCC groups.
  
  
  CONCLUSIONS
  Some of the polymorphisms of hTERT may increase the risks of development and metastasis of hepatocellular carcinoma.
authors.affiliation: Department of Clinical Biochemistry, General Hospital of PLA, Beijing 100853, China. dongdong6214@yahoo.com.cn
authors.forename: Jin
authors.initials: J
authors.lastname: Dong
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Tian
authors.forename: Yue
authors.initials: Y
authors.lastname: Guo
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Liu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D019098:Telomerase / Q000235:genetics*
chemical_list: C509186:TERT protein, human; D019098:Telomerase