title: Dentin hypersensitivity reduction of a new toothpaste containing 8.0% arginine and 1450 ppm fluoride: an 8-week clinical study on Chinese adults.
abstract: OBJECTIVE
  To present the results of an 8-week dentin hypersensitivity clinical study in which the efficacy of a new Pro-Argin formula toothpaste, with gentle whitening benefits, containing 8.0% arginine, a high cleaning calcium carbonate system, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) was compared to that of a commercial Pro-Argin formula toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride as MFP and a negative control toothpaste containing calcium carbonate and 1450 ppm fluoride as MFP.
  
  
  METHODS
  An 8-week clinical study, with 121 subjects, was conducted in Chengdu, Sichuan, China, using a double-blind, stratified, three-treatment design. Tactile and air blast sensitivity assessments were used to compare the efficacy of the three products.
  
  
  RESULTS
  This clinical study demonstrated that the new Pro-Argin formula toothpaste provided a significant reduction in dentin hypersensitivity when used over a period of 8 weeks. The study also showed that the new toothpaste provided significantly greater reductions (P < 0.05) in dentin hypersensitivity in response to tactile (64.4%, 71.1%, and 61.0%) and air blast (40.7%, 58.8%, and 74.4%) stimuli than the negative control toothpaste containing 1450 ppm fluoride after 2, 4, and 8 weeks of product use, respectively. The results for the new toothpaste did not differ significantly from those of the positive control toothpaste at all time points in the study.
authors.affiliation: The Key State Laboratory of Oral Diseases, Sichuan University, Chengdu, China.
authors.forename: Kehua
authors.initials: K
authors.lastname: Que
authors.forename: Yingying
authors.initials: Y
authors.lastname: Fu
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Deyu
authors.initials: D
authors.lastname: Hu
authors.forename: Yun Po
authors.initials: YP
authors.lastname: Zhang
authors.forename: Fotinos S
authors.initials: FS
authors.lastname: Panagakos
authors.forename: William
authors.initials: W
authors.lastname: DeVizio
authors.forename: Luis R
authors.initials: LR
authors.lastname: Mateo
mesh_terms: D000368:Aged; D001120:Arginine / Q000627:therapeutic use; D002119:Calcium Carbonate / Q000627:therapeutic use; D057133:Dentin Desensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010710:Phosphates / Q000627:therapeutic use; D058205:Tooth Bleaching Agents; D014100:Toothpastes / Q000737:chemistry / Q000627:therapeutic use*; D014110:Touch
chemical_list: D057133:Dentin Desensitizing Agents; D010710:Phosphates; D058205:Tooth Bleaching Agents; D014100:Toothpastes; C012980:fluorophosphate; D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides