title: Protective effect of α-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats.
abstract: The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity. In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in combination with LA. In the acute study, continuous ECG recording revealed that intravenous injection of ATO caused transient ST-T change, whereas pretreatment with LA abolished the ATO-induced ECG abnormality in all animals. These results suggest that LA protects against the ATO-induced acute cardiac toxicity and subsequent sudden death in rats.
authors.affiliation: Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kumazaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ando
authors.forename: Akira
authors.initials: A
authors.lastname: Sasaki
authors.forename: Taka-Aki
authors.initials: TA
authors.lastname: Koshimizu
authors.forename: Kentarou
authors.initials: K
authors.lastname: Ushijima
authors.forename: Keiko
authors.initials: K
authors.lastname: Hosohata
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Oshima
authors.forename: Akio
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D000077237:Arsenic Trioxide; D001152:Arsenicals; D003404:Creatinine / Q000097:blood; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D010087:Oxides / Q000633:toxicity*; D020011:Protective Agents / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000494:pharmacology*; D013997:Time Factors; D000637:Transaminases / Q000097:blood*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001152:Arsenicals; D010087:Oxides; D020011:Protective Agents; D008063:Thioctic Acid; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003404:Creatinine; D000637:Transaminases; D000469:Alkaline Phosphatase; D003849:Deoxyguanosine; D000077237:Arsenic Trioxide