title: Sugar-bearing tetraphenylethylene: novel fluorescent probe for studies of carbohydrate-protein interaction based on aggregation-induced emission.
abstract: Neutral sugar-bearing tetraphenylethenes (TPE) are designed and prepared as "turn-on" luminescent sensors for lectins and glycosidases based on aggregation-induced emission. Through aggregation derived from carbohydrate-lectin binding, multivalent mannosyl-bearing TPE shows a good selectivity and sensitivity to Con A by switching on the fluorescence of water-soluble tetraphenylethylene-based glyco-conjugates in aqueous solution. Meanwhile, cellobiosyl-bearing TPE can be used to investigate enzymatic hydrolysis based on emission enhancing by glycosidase-induced aggregation.
authors.affiliation: National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Jin-Xiang
authors.initials: JX
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Bian
authors.forename: Fen
authors.initials: F
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Ai-Di
authors.initials: AD
authors.lastname: Qi
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan
authors.forename: Bao-Hang
authors.initials: BH
authors.lastname: Han
mesh_terms: D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D005030:Ethylenes / Q000032:analysis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000032:analysis*; D006868:Hydrolysis; D037102:Lectins / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure
chemical_list: D002241:Carbohydrates; D005030:Ethylenes; D005456:Fluorescent Dyes; D037102:Lectins; C036216:ethylene