title: Actinomycins like anti-cancer photo-sensitizers.
abstract: Spectroscopic and microscopic study on application of actinomycins as anti-tumor photo-sensitizing drugs was carried out in this work. It has been shown that 7-aminoactinomycin (7AAMD) and actinomycin D (AMD) inside cells of line HeLa bind not only with DNA, but also with proteins. Fluorescence of 7AAMD in HeLa cells and destruction of these cells by photosensitizing with actinomycin D were detected. When photo-destruction occurs, the antibiotic is released out from destroyed cells.
authors.affiliation: Institute of Cell Biophysics of Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia. nvekshin@rambler.ru
authors.forename: Nikolai
authors.initials: N
authors.lastname: Vekshin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D003609:Dactinomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D003609:Dactinomycin; C025942:7-aminoactinomycin D