title: Highly enantioselective synthesis of polysubstituted tetrahydroquinolines via organocatalytic Michael/Aza-Henry tandem reactions.
abstract: Highly enantioselective chiral bifunctional thiourea catalyzed asymmetric tandem reactions for synthesis of substituted tetrahydroquinolines are described. Substituted tetrahydroquinolines were given in good yields (up to 98%), high enantioselectivities (up to >99% ee), and diastereoselectivities (up to 20:1 dr).
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P R China.
authors.forename: Zhen-Xin
authors.initials: ZX
authors.lastname: Jia
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Luo
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D011804:Quinolines; C542964:1,2,3,4-tetrahydroquinoline; D013890:Thiourea