title: Effects of sleeve gastrectomy in neonatally streptozotocin-induced diabetic rats.
abstract: BACKGROUND
  Sleeve gastrectomy (SG) has emerged recently as a stand-alone bariatric procedure to treat morbid obesity and enhance glucose homeostasis. The aim of the study was to evaluate its effects in neonatally streptozotocin (STZ)-induced diabetic rats (n-STZ diabetic rats).
  
  
  RESULTS
  To induce diabetes, STZ (90 mg/kg) was administered intraperitoneally to 2-day-old male pups. When 12 weeks old, diabetic rats were randomized into sleeve operation group (SLG, n = 6) and sham operation group (SOG, n = 6). Body weights were monitored weekly, and daily consumption of water and food were followed for eight consecutive weeks postoperatively. Serum glucose levels were measured periodically at the 4th and 8th week after surgery. Insulin, ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide-1 (GLP-1) levels were assayed at the end of the study. Our data showed that SLG rats exhibited significantly lower body weight gain in addition to reduced food and water intakes postoperatively compared to their sham-operation counterparts. However, resolution of diabetes was not observed in our study. Correspondingly, there were no significant differences between SOG rats and SLG rats in glucose metabolism-associated hormones, including insulin, GIP and GLP-1. In contrast, ghrelin level significantly decreased (P<0.01) in SLG group (58.01 ± 3.75 pg/ml) after SG surgery compared to SOG group (76.36 ± 3.51 pg/ml).
  
  
  CONCLUSIONS
  These observations strongly suggest that SG is effective in controlling body weight. However, SG did not achieve resolution or improvement of diabetes in n-STZ diabetic rats.
authors.affiliation: Department of Pharmacology, Basic Medical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.wangyantj2008@yahoo.com.cn
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Lingling
authors.initials: L
authors.lastname: Yan
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Jin
authors.forename: Xin
authors.initials: X
authors.lastname: Xin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D005743:Gastrectomy / Q000379:methods*; D008297:Male; D051381:Rats; D013311:Streptozocin; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D013311:Streptozocin