title: Alice-in-Wonderland syndrome--a case-based update and long-term outcome in nine children.
abstract: OBJECTIVE
  There are some reports of so-called Alice-in-Wonderland syndrome mostly concerning differential diagnosis, association with a variety of infectious diseases and even some case reports on functional imaging. Long-term data are rare.
  
  
  METHODS
  Nine boys aged 6 to 11 years that had been diagnosed with Alice-in-Wonderland syndrome between 2003 and 2008 were contacted for a long-term follow-up study in summer, 2009, with a mean follow-up of 4.6 years.
  
  
  RESULTS
  At the time of the follow-up study, all children were in good general and mental health. Symptoms of Alice-in-Wonderland syndrome had ceased within weeks or months. In two patients, episodes of metamorphopsia returned after a symptom-free latency of 3 years and 1 year, respectively. Five children had a family history of migraine or epilepsy. In one case, the father was reported to have experienced similar symptoms when he was a child.
  
  
  CONCLUSIONS
  Our follow-up study shows that Alice-in-Wonderland is most likely a benign, self-terminating childhood condition, although occasional recurrences of symptoms are possible.
authors.affiliation: Wagener-Stiftung für Sozialpädiatrie, Heusnerstr. 40, 42283, Wuppertal, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Weidenfeld
authors.forename: Peter
authors.initials: P
authors.lastname: Borusiak
mesh_terms: D002648:Child; D005074:Evoked Potentials, Visual / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis / Q000503:physiopathology; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis* / Q000503:physiopathology*