title: Histological evaluation of the effect of using growth hormone around immediate dental implants in fresh extraction sockets: an experimental study.
abstract: OBJECTIVE
  The aim of this study was to histologically evaluate the effect of using growth hormone (GH) around immediate dental implants in fresh extraction sockets.
  
  
  METHODS
  Six mongrel dogs had had their lower right and left first premolars extracted. For the right side, the control side, implants were placed immediately. For the left sides, the study side, GH powder was placed in the socket and then immediate implant placement was done. Animals were killed at 2, 6, and 12 weeks after surgery, and histological sections were stained with hematoxylin and eosin, and trichrome stains, and observed under light microscopy for the newly formed bone.
  
  
  RESULTS
  Bone formation was obvious in both groups. But in study group, bone density had denser and well-oriented collagen fibers. An increase in bone response was observed with high local administration of GH. In the first phases of bone repair, the osteons were more organized; they were more organized by the 12th week.
  
  
  CONCLUSIONS
  The use of GH powder around dental implants placed immediately in fresh extraction sockets enhanced periimplant bone response.
authors.affiliation: Dental Implantology, Alexandria Dental Research Center, Alexandria, Egypt. dr.assem@gmail.com
authors.forename: Assem M
authors.initials: AM
authors.lastname: Hossam Eldein
authors.forename: Sherif H
authors.initials: SH
authors.lastname: Elghamrawy
authors.forename: Saeeda M
authors.initials: SM
authors.lastname: Osman
authors.forename: Amal R
authors.initials: AR
authors.lastname: Elhak
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000601:surgery; D015519:Bone Density / Q000187:drug effects; D003094:Collagen / Q000648:ultrastructure; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D015921:Dental Implants; D004285:Dogs; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D006253:Haversian System / Q000187:drug effects / Q000473:pathology; D019382:Human Growth Hormone / Q000627:therapeutic use*; D057893:Immediate Dental Implant Loading; D008334:Mandible / Q000473:pathology / Q000601:surgery; D010006:Osteoblasts / Q000187:drug effects / Q000473:pathology; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010012:Osteogenesis / Q000187:drug effects; D011994:Recombinant Proteins / Q000627:therapeutic use; D013997:Time Factors; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects* / Q000473:pathology / Q000601:surgery
chemical_list: D015921:Dental Implants; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D003094:Collagen