title: First experience with the Prismaflex HF 20 set in four infants.
abstract: OBJECTIVE
  Renal replacement therapy (RRT) in infants is challenging due to a lack of widely available technology that is specific to this patient population. We present our initial experience with the newly developed Prismaflex HF20 disposable set used on the Prismaflex device in infants with renal failure.
  
  
  METHODS
  Four infants, age 5 to 24 months, were enrolled. Overall 120 treatment sessions were performed over 300 patient-days. Treatment monitoring included patient weight change and fluid balance, treatment efficacy, number of interventions, and alarms.
  
  
  RESULTS
  Desired fluid balance according to the prescribed weight loss was achieved in all patients (R²=0.86, p<0.0001). Treatment efficacy was monitored by blood urea nitrogen (BUN) and serum creatinine values at the start of RRT (59 ± 17 mg/dL and 5.1 ± 1.1 mg/dL) and their decrease after 4 hours of RRT (23 ± 7 mg/dL and 2.2 ± 0.6 mg/dL). Measured urea and creatinine clearances for the HF20 filter were 23 ± 7 ml/min and 19 ± 4 ml/min, respectively. No complications occurred.
  
  
  CONCLUSIONS
  This is the first report on the use of the Prismaflex HF20 set in infants. No adverse events were observed, treatments were well tolerated in all patients, and flow rate adaptability to infants' needs was good.
authors.affiliation: Department of Pediatrics, Pediatric Intensive Care Unit, Medical University of Graz, Graz - Austria. siegfried.roedl@medunigraz.at
authors.forename: Siegfried
authors.initials: S
authors.lastname: Rödl
authors.forename: Ingrid
authors.initials: I
authors.lastname: Marschitz
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Mache
authors.forename: Martin
authors.initials: M
authors.lastname: Koestenberger
authors.forename: Georg
authors.initials: G
authors.lastname: Madler
authors.forename: Thomas
authors.initials: T
authors.lastname: Rehak
authors.forename: Gerfried
authors.initials: G
authors.lastname: Zobel
mesh_terms: D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004209:Disposable Equipment; D004867:Equipment Design; D017583:Hemodiafiltration / Q000295:instrumentation*; D006801:Humans; D007223:Infant; D051437:Renal Insufficiency / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D003404:Creatinine