title: Paracoccidioidomycosis: cells expressing IL17 and Foxp3 in cutaneous and mucosal lesions.
abstract: We demonstrated and quantified by immunohistochemistry the population of cells expressing IL17 and Foxp3 in cutaneous and mucosal paracoccidioidomycosis lesions, associating these populations of cells with different presentations of granulomatous response. For this purpose, 61 skin biopsies and 55 oral mucosal biopsies were evaluated. Cells expressing IL17 were distributed in the inflammatory infiltrate in both groups of lesions and were found in the vessels' wall too. Foxp3+ expression was limited to the nuclei of lymphocytes in the inflammatory infiltrate. The distribution of IL17 was similar among the groups; however, Foxp3+ cells were increased in mucosal lesions that displayed compact granulomas. The results suggest that IL17 seems to play a role in paracoccidioidomycosis cutaneous and mucosal lesions, probably as secondary cells in the clearance of the fungal antigens. The presence of Foxp3+ cells both in skin and mucosa corroborates some previous researches that suggest the role of this group of cells in the modulation of local immune response.
authors.affiliation: Laboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Brazil. cpagliari@usp.br
authors.forename: Carla
authors.initials: C
authors.lastname: Pagliari
authors.forename: Elaine Raniero
authors.initials: ER
authors.lastname: Fernandes
authors.forename: Felipe Weisshaupt
authors.initials: FW
authors.lastname: Stegun
authors.forename: Wellington Luiz F
authors.initials: WL
authors.lastname: da Silva
authors.forename: Maria Irma
authors.initials: MI
authors.lastname: Seixas Duarte
authors.forename: Mirian N
authors.initials: MN
authors.lastname: Sotto
mesh_terms: D001706:Biopsy; D051858:Forkhead Transcription Factors / Q000032:analysis*; D006099:Granuloma / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D020381:Interleukin-17 / Q000032:analysis*; D008214:Lymphocytes / Q000737:chemistry* / Q000276:immunology*; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology*; D010229:Paracoccidioidomycosis / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000473:pathology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D020381:Interleukin-17