title: Antioxidant and antiasthmatic effects of saucerneol D in a mouse model of airway inflammation.
abstract: Chronic airway inflammation is a hallmark of asthma, which is an immune-based disease. We evaluated the ability of saucerneol D, a tetrahydrofuran-type sesquilignan isolated from Saururus chinensis, to regulate airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Furthermore, we determined whether heme oxygenase (HO)-1 was required for the protective activity of saucerneol D. The airways of OVA-sensitized mice exposed to an OVA challenge developed eosinophilia and mucus hypersecretion and exhibited increased cytokine levels. Mice were administered saucerneol D orally at doses of 20 and 40mg/kg once daily on days 26-30. Saucerneol D administered orally significantly inhibited the number of OVA-induced inflammatory cells and the production of immunoglobulin E as well as Th2-type cytokines. Histopathology studies revealed a marked decrease in lung inflammation and goblet cell hyperplasia after saucerneol D treatment. In addition, saucerneol D induced HO-1 and led to a marked decrease in OVA-induced reactive oxygen species and malondialdehyde and an increase in superoxide dismutase and glutathione in lung tissues. These antioxidant effects were correlated with HO-1 induction. In our experiments, saucerneol D treatment reduced airway inflammation and suppressed oxidative stress in an OVA-induced asthma model.
authors.affiliation: Research Institute of Veterinary Medicine and College of Veterinary Medicine, Chungnam National University, Yusung-gu, Daejeon, Korea.
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Jung
authors.forename: Kyoung-youl
authors.initials: KY
authors.lastname: Lee
authors.forename: Mee-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Dayoung
authors.initials: D
authors.lastname: Jung
authors.forename: Eun-Sang
authors.initials: ES
authors.lastname: Cho
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Son
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D017705:Lignans / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D011014:Pneumonia / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D017382:Reactive Oxygen Species / Q000378:metabolism; D032134:Saururaceae / Q000276:immunology; D058408:Th1-Th2 Balance / Q000187:drug effects
chemical_list: D018927:Anti-Asthmatic Agents; D000975:Antioxidants; D016207:Cytokines; D017705:Lignans; D017382:Reactive Oxygen Species; C561428:saucerneol D; D007073:Immunoglobulin E; D006419:Heme Oxygenase (Decyclizing)