title: Pregnancy in women with a systemic right ventricle after surgically and congenitally corrected transposition of the great arteries.
abstract: OBJECTIVE
  To determine maternal and neonatal outcomes in women with a systemic right ventricle (RV).
  
  
  METHODS
  A retrospective (historical) cohort study of maternal and neonatal outcomes at a tertiary referral academic obstetric unit (Chelsea and Westminster Hospital, London).
  
  
  RESULTS
  Nineteen pregnancies in 14 women with a systemic RV were compared with 76 controls. There were no maternal deaths. In the study group cardiac complications occurred in six (32%) pregnancies. Obstetric complications occurred in four (21%) case pregnancies, not significantly higher than in the control group. The rate of neonatal complication was significantly higher in the study population with neonatal complications in 12 (63%) case pregnancies compared with 13 (17%) control pregnancies. The median birthweight centile was 9 in the study population, significantly lower than the control population.
  
  
  CONCLUSIONS
  Our cohort study demonstrates high maternal and neonatal morbidity and low birthweight in the presence of a systemic RV. Cardiac complications were more common in women with RV dysfunction and arrhythmias prior to pregnancy. Preconception counselling and tertiary care during pregnancy for these patients is highly advisable.
authors.affiliation: Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK. eshgelson@hotmail.com
authors.forename: Emily
authors.initials: E
authors.lastname: Gelson
authors.forename: Ruth
authors.initials: R
authors.lastname: Curry
authors.forename: Michael A
authors.initials: MA
authors.lastname: Gatzoulis
authors.forename: Lorna
authors.initials: L
authors.lastname: Swan
authors.forename: Martin
authors.initials: M
authors.lastname: Lupton
authors.forename: Jackie
authors.initials: J
authors.lastname: Durbridge
authors.forename: Charlotte
authors.initials: C
authors.lastname: Deans
authors.forename: Phillip
authors.initials: P
authors.lastname: Steer
authors.forename: Mark R
authors.initials: MR
authors.lastname: Johnson
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D000080041:Congenitally Corrected Transposition of the Great Arteries; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008131:London / Q000453:epidemiology; D008297:Male; D007744:Obstetric Labor Complications / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011654:Pulmonary Edema / Q000453:epidemiology; D012189:Retrospective Studies; D014188:Transposition of Great Vessels / Q000150:complications / Q000601:surgery*; D018497:Ventricular Dysfunction, Right / Q000209:etiology* / Q000503:physiopathology; D055815:Young Adult