title: Short-term therapy with high dose atorvastatin in patients with coronary artery disease can reduce inflammatory process.
abstract: Coronary heart disease is the leading cause of death and disability in adults. The association between acute coronary syndrome (ACS) and elevated serum high sensitivity c-reactive protein (hsCRP) suggests that chronic inflammation of the coronary arterial wall may play an important role. A number of drugs used in the treatment of cardiovascular disease reduce serum CRP. It* is therefore possible that reduced inflammation contributes to the beneficial effects of these medications. This was a double blind randomized clinical trial on 52 patients were admitted because of ACS at the Mazandaran Heart Center, Iran in 2007. The patients were divided to three randomized groups which received 20, 40, 80* mg Atorvastatin daily for 6 months. At the time of study enrollment and 1, 3 and 6 months after initiation hsCRP were measured. 1 and 3 month after 20mg atorvastatin therapy the median serum concentration of hsCRP did not decrease significantly, but at the end of 6th month it was* significant difference. At 40 mg dosage from 3rd month to 6th month versus 1st month to 3rd month it was significant decrease, at the end of 1st month and 3rd month it was not significant. At 80 mg dose at the end of 1st month it was not significant but at the* end of 3rd month and end of 6th month it was significant. Intensive lipid-lowering therapy with high-dose atorvastatin therapy relative to moderate lipid-lowering therapy with low-dose atorvastatin reduces hsCRP better. We found that treatment with greater dose of atorvastatin might decrease greater in plasma level of hsCRP.
authors.affiliation: Department of Internal Cardiology, Fatemeh Zahra Hospital of Sari, Mazandaran University of Medical Sciences, Mazandaran, Iran. vida196180@yahoo.com
authors.forename: Vida
authors.initials: V
authors.lastname: Nesar Hossein
authors.forename: Keivan
authors.initials: K
authors.lastname: Yosef Nejad
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Abdollahian
mesh_terms: D000069059:Atorvastatin; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007249:Inflammation / Q000150:complications / Q000188:drug therapy*; D011758:Pyrroles / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D002097:C-Reactive Protein; D000069059:Atorvastatin