title: [Adrenal androgen participation in the polycystic ovary syndrome].
abstract: OBJECTIVE
  to reassess the adrenal function of patients with PCOS after the introduction of the Rotterdam's criteria.
  
  
  METHODS
  descriptive and cross-sectional study including 53 patients 26 ± 5.1 years old. Glucose, glycosylated hemoglobin, lipids, estradiol, progesterone, 17-OHP4, DHEAS, FSH, LH, TSH, PRL, androstenedione, free thyroxine, insulin, total testosterone, SHBG, and free androgen index were measured. Insulin resistance was considered to be present with a homeostatic model assessment index >2.8. The adrenal response to cortrosyn was assessed by the hormonal rise observed at 60 minutes, and by the area under the response curve.
  
  
  RESULTS
  biochemical hyperandrogenism was found in 43 of 53 eligible patients (81.1%). Thirty-three women had adrenal hyperandrogenism (62.2%). The weight of these 33 women, aging 25.1 ± 5.0 years, was 74.9 ± 14.9 kg, BMI was 28.8 ± 6.0 and the waist/hip ratio was 0.8 ± 0.1. DHEAS was >6.7 nmol/L in 13 (39.4%) and androstenendione was >8.7 nmol/L in 31 (93.9%). The increments in 17-OHP4, cortisol, A, and progesterone were 163%, 153%, 32%, and 79%, respectively. The homeostatic insulin resistance model was >2.8 in 14 (42.4%). Insulin and estradiol were not correlated with cortisol or androgens.
  
  
  CONCLUSIONS
  the use of multiple endocrine parameters showed a high prevalence of biochemical hyperandrogenism in patients with PCOS. Two thirds of the patients had adrenal hyperandrogenism, and estradiol and insulin did not influence adrenal secretion.
authors.affiliation: Médico do Hospital Universitário Júlio Müller da Universidade Federal de Mato Grosso – UFMT Cuiabá (MT), Brasil.
authors.forename: Angelo Barrionuevo
authors.initials: AB
authors.lastname: Gil Junior
authors.forename: Ana Paula Rodrigues
authors.initials: AP
authors.lastname: Rezende
authors.forename: Anselmo Verlangieri
authors.initials: AV
authors.lastname: do Carmo
authors.forename: Erico Isaias
authors.initials: EI
authors.lastname: Duarte
authors.forename: Márcia Marly Winck Yamamoto
authors.initials: MM
authors.lastname: de Medeiros
authors.forename: Sebastião Freitas
authors.initials: SF
authors.lastname: de Medeiros
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood* / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications*; D011446:Prospective Studies
chemical_list: D000728:Androgens