title: [Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy].
abstract: OBJECTIVE
  In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death, pathogenesis and relationship between the viral myocarditis (VMC) and dilated cardiomyopathy (DCM) were investigated.
  
  
  METHODS
  Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples, including 22 deceased with VMC, 20 deceased with DCM and 16 control deceased.
  
  
  RESULTS
  The brown staining on the cell membrane of myocardium showed positive result. There was a prominent CAR expression in VMC group and DCM group, which were statistically significant difference compared with control group (P < 0.05).
  
  
  CONCLUSIONS
  The CAR expression showed significantly higher in VMC and DCM groups. The viral infection can result in myocardial necrosis and impaired cardiac functions. These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.
authors.affiliation: Department of Forensic Medicine, Medical College of Nantong University, Nantong 226001, China. whhongfei@sina.com
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Xu
authors.forename: Jian-Lei
authors.initials: JL
authors.lastname: Chen
authors.forename: Xu-Ping
authors.initials: XP
authors.lastname: Da
authors.forename: Ke-Rong
authors.initials: KR
authors.lastname: Wu
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Liu
authors.forename: Zi-Qin
authors.initials: ZQ
authors.lastname: Zhao
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Han
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D003384:Coxsackievirus Infections / Q000150:complications; D016757:Death, Sudden, Cardiac; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009205:Myocarditis / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011991:Receptors, Virus / Q000378:metabolism*; D013194:Staining and Labeling
chemical_list: C568771:CLMP protein, human; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus