title: The incidence of hepatocellular carcinoma associated with hepatitis C infection decreased in Kyushu area.
abstract: BACKGROUND
  The incidence of hepatocellular carcinoma (HCC) in Japan has still been increasing. The aim of the present study was to analyze the epidemiological trend of HCC in the western area of Japan, Kyushu.
  
  
  METHODS
  A total of 10,010 patients with HCC diagnosed between 1996 and 2008 in the Liver Cancer study group of Kyushu (LCSK), were recruited for this study. Cohorts of patients with HCC were categorized into five year intervals. The etiology of HCC was categorized to four groups as follows; B: HBsAg positive, HCV-RNA negative, C: HCV-RNA positive, HBsAg negative, B+C: both of HBsAg and HCV-RNA positive, nonBC: both of HBsAg and HCV-RNA negative.
  
  
  RESULTS
  B was 14.8% (1,485 of 10,010), whereas 68.1% (6,819 of 10,010) had C, and 1.4% (140 of 10,010) had HCC associated with both viruses. The remaining 1,566 patients (15.6%) did not associate with both viruses.<br /> Cohorts of patients with HCC were divided into six-year intervals (1996-2001 and 2002-2007). The ratio of C cases decreased from 73.1% in 1996-2001 to 64.9% in 2002-2007. On the other hand, B and -nonBC cases increased significantly from 13.9% and 11.3% in 1996-2001 to 16.2% and 17.6% in 2002-2007, respectively.
  
  
  CONCLUSIONS
  The incidence of hepatocellular carcinoma associated with hepatitis C infection decreased after 2001 in Kyushu area. This change was due to the increase in the number and proportion of the HCC not only nonBC patients but also B patients.
authors.affiliation: Clinical Research Center, National Nagasaki Medical Center, Omura City, Nagasaki, Japan.
authors.forename: Naota
authors.initials: N
authors.lastname: Taura
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Fukushima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yastuhashi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takami
authors.forename: Masataka
authors.initials: M
authors.lastname: Seike
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mizuta
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagata
authors.forename: Akinari
authors.initials: A
authors.lastname: Tabara
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Komorizono
authors.forename: Akinobu
authors.initials: A
authors.lastname: Taketomi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tamai
authors.forename: Toyokichi
authors.initials: T
authors.lastname: Muro
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Kunitaka
authors.initials: K
authors.lastname: Fukuizumi
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Maeshiro
authors.forename: Osami
authors.initials: O
authors.lastname: Inoue
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000150:complications* / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult