title: Pernicious anemia - genetic insights.
abstract: Pernicious anemia (PA) is a complex, autoimmune, multi-factorial disease. Rapid progress has been made in the understanding of susceptibility to a spectrum of other autoimmune diseases through genome wide association studies (GWAS). However, PA has been conspicuous by its absence from this work. Here, we examine the evidence that PA has a significant heritable component through epidemiological evidence and its co-occurrence with other autoimmune diseases. Further, we consider how knowledge of the genetic susceptibility to other autoimmune diseases may provide insight into the etiology of PA.
authors.affiliation: Genetic Medicine, St Mary's Hospital, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, M13 9WL, UK. Siddharth.Banka@manchester.ac.uk
authors.forename: Siddharth
authors.initials: S
authors.lastname: Banka
authors.forename: Kate
authors.initials: K
authors.lastname: Ryan
authors.forename: Wendy
authors.initials: W
authors.lastname: Thomson
authors.forename: William G
authors.initials: WG
authors.lastname: Newman
mesh_terms: D000752:Anemia, Pernicious / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D003038:Cobamides / Q000172:deficiency; D015897:Comorbidity; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D007437:Intrinsic Factor / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011110:Polymorphism, Genetic
chemical_list: D003038:Cobamides; D007437:Intrinsic Factor