title: Improvement in sexual functioning in patients with type 2 diabetes and depression treated with bupropion.
abstract: OBJECTIVE
  Major depressive disorder (MDD) and type 2 diabetes have independent adverse effects on sexual functioning (SF). Bupropion (BU) reportedly has few sexual side effects, but its use in diabetes has not been studied.
  
  
  METHODS
  This article reports a planned secondary analysis of SF in 90 patients with type 2 diabetes treated with BU for MDD.
  
  
  RESULTS
  At baseline, 71.1% of patients had insufficient SF. Mean Sexual Energy Scale (SES) scores improved during treatment (P < 0.0001), as did the percentage with sufficient SF (30.6 vs. 68.1%, P = 0.001). Patients with persistent hyperglycemia had higher rates of sexual dysfunction; however, SES improvement was evident in some with persistent depression or hyperglycemia (18.2% and 25.9%, respectively).
  
  
  CONCLUSIONS
  Insufficient SF is prevalent and may be suspected in patients with MDD and type 2 diabetes. BU treatment of MDD had few sexual side effects and was associated with significant improvements in SF.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Sayuk
authors.forename: Britt M
authors.initials: BM
authors.lastname: Gott
authors.forename: Billy D
authors.initials: BD
authors.lastname: Nix
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Lustman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects; D016642:Bupropion / Q000008:administration & dosage* / Q000009:adverse effects; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior / Q000187:drug effects*; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion