title: Taurine prevents hypertension and increases exercise capacity in rats with fructose-induced hypertension.
abstract: BACKGROUND
  Fructose-induced hypertension was used to test the hypothesis that taurine supplementation and/or exercise can prevent hypertension and increase exercise capacity.
  
  
  METHODS
  Five groups of 15 Sprague-Dawley rats were allocated and designated as control, high fructose-fed (fructose), high fructose-fed plus exercise (FE), high fructose-fed plus 2% taurine supplement (FT) and high fructose-fed plus 2% taurine supplement and exercise (FET) groups. Noninvasive systolic blood pressure (SBP) was recorded weekly and invasive arterial blood pressure (ABP) was recorded at the end of the 4-week trial. Three consecutive swimming tests were performed in the selected rats from each group and the plasma biomarkers were measured in the remaining rats.
  
  
  RESULTS
  Noninvasive SBP differed significantly (P < 0.001) from week 3, both noninvasive and invasive ABP increased significantly (P < 0.001), and exercise capacity significantly decreased (P < 0.001) in the fructose group compared with the control group. The individual effects of swimming and taurine supplementation were incapable of preventing the development of hypertension and SBP significantly (P < 0.001) increased in the FE and FT groups; exercise capacity in those groups remained similar to control. The combined effects of exercise and taurine alleviated hypertension and significantly increased exercise capacity in the FET group. Insulin resistance increased significantly and plasma nitric oxide (NO) decreased significantly in the F, FE, and FT groups. Both parameters remained similar to control values in the FET group with an increasing antioxidant activity.
  
  
  CONCLUSIONS
  Taurine supplementation in combination with exercise prevents hypertension and increases exercise capacity by possibly antioxidation and maintaining NO concentrations.
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Medicine, Chonbuk National University, Jeonju, Republic of Korea.
authors.forename: Mizanur M
authors.initials: MM
authors.lastname: Rahman
authors.forename: Hye-Min
authors.initials: HM
authors.lastname: Park
authors.forename: Shang-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Hyeon-Kyu
authors.initials: HK
authors.lastname: Go
authors.forename: Gi-Beum
authors.initials: GB
authors.lastname: Kim
authors.forename: Chul-Un
authors.initials: CU
authors.lastname: Hong
authors.forename: Young-Up
authors.initials: YU
authors.lastname: Lee
authors.forename: Sung-Zoo
authors.initials: SZ
authors.lastname: Kim
authors.forename: Jin-Shang
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyung-Sub
authors.initials: HS
authors.lastname: Kang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D004573:Electrolytes / Q000097:blood; D005632:Fructose / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009573:Nitrites / Q000097:blood; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming; D013599:Systole; D013654:Taurine / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D007328:Insulin; D009573:Nitrites; D013654:Taurine; D005632:Fructose; D003402:Creatine Kinase; D005978:Glutathione