title: A dynamic model for functional mapping of biological rhythms.
abstract: Functional mapping is a statistical method for mapping quantitative trait loci (QTLs) that regulate the dynamic pattern of a biological trait. This method integrates mathematical aspects of biological complexity into a mixture model for genetic mapping and tests the genetic effects of QTLs by comparing genotype-specific curve parameters. As a way of quantitatively specifying the dynamic behavior of a system, differential equations have proven to be powerful for modeling and unraveling the biochemical, molecular, and cellular mechanisms of a biological process, such as biological rhythms. The equipment of functional mapping with biologically meaningful differential equations provides new insights into the genetic control of any dynamic processes. We formulate a new functional mapping framework for a dynamic biological rhythm by incorporating a group of ordinary differential equations (ODE). The Runge-Kutta fourth order algorithm was implemented to estimate the parameters that define the system of ODE. The new model will find its implications for understanding the interplay between gene interactions and developmental pathways in complex biological rhythms.
authors.affiliation: Center for Statistical Genetics, Pennsylvania State University, Hershey, PA 17033, USA.
authors.forename: Guifang
authors.initials: G
authors.lastname: Fu
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Luo
authors.forename: Arthur
authors.initials: A
authors.lastname: Berg
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiahan
authors.initials: J
authors.lastname: Li
authors.forename: Kiranmoy
authors.initials: K
authors.lastname: Das
authors.forename: Runze
authors.initials: R
authors.lastname: Li
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D003198:Computer Simulation; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D040641:Quantitative Trait Loci