title: Angiogenesis in meningiomas.
abstract: Neoangiogenesis has been correlated to biological aggressiveness and an adverse clinical course of several neoplasias. Its prognostic role in meningiomas appears to be controversial. Nonetheless, if adequately quantified with specific markers and appropriate scoring methods, angiogenesis seems to be significantly associated with a high growth fraction, development of recurrences and shorter overall survival of meningiomas. As a consequence, neoangiogenesis may represent a target for therapies aimed at reducing the growth of inoperable meningiomas or recurrence risk of totally resected tumors. Even more significantly, the identification of the factors that mediate angiogenesis in meningiomas could help us to determine appropriate novel anti-angiogenic therapies for these tumors. Herein the methods for quantification of angiogenesis as well as its regulating factors in meningiomas are reviewed.
authors.affiliation: Department of Human Pathology, University of Messina, Messina, Italy. vbarresi@unime.it
authors.forename: Valeria
authors.initials: V
authors.lastname: Barresi
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000032:analysis*; D051242:Caveolin 1 / Q000378:metabolism; D000071063:Endoglin; D019332:Endothelin-1 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008579:Meningioma / Q000098:blood supply / Q000175:diagnosis / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000378:metabolism*; D039942:Neuropilin-1 / Q000378:metabolism; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D040121:Semaphorin-3A / Q000378:metabolism; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D051242:Caveolin 1; C064206:ENG protein, human; D000071063:Endoglin; D019332:Endothelin-1; D011956:Receptors, Cell Surface; D040121:Semaphorin-3A; D042461:Vascular Endothelial Growth Factor A; D039942:Neuropilin-1; D013004:Somatostatin; D020780:Matrix Metalloproteinase 9