title: Does ghrelin level change after epileptic seizure in rats?
abstract: OBJECTIVE
  Epilepsy is one of the most common neurologic problems worldwide. A relationship between epilepsy and hormones has been demonstrated. This study was designed to investigate the effect of seizure on blood ghrelin level.
  
  
  METHODS
  Twenty male Wistar rats were divided into two groups. The control group received saline and the pentylenetetrazole (PTZ) group received a single convulsive dose (50mg/kg) of PTZ. Thirty minutes later blood samples were collected and acylated and unacylated ghrelin levels in the plasma were assayed.
  
  
  RESULTS
  Acylated or active form of ghrelin decreased significantly (p<0.05) after a PTZ-induced seizure, but the reduction of unacylated and total blood ghrelin levels failed to reach statistical significance.
  
  
  CONCLUSIONS
  These findings may reflect that PTZ-induced epilepsy decreases AG of plasma.
authors.affiliation: Drug Applied Research Centre of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Ataie
authors.forename: M G
authors.initials: MG
authors.lastname: Golzar
authors.forename: Sh
authors.initials: Sh
authors.lastname: Babri
authors.forename: H
authors.initials: H
authors.lastname: Ebrahimi
authors.forename: G
authors.initials: G
authors.lastname: Mohaddes
mesh_terms: D000818:Animals; D003292:Convulsants / Q000633:toxicity; D004827:Epilepsy / Q000097:blood*; D054439:Ghrelin / Q000097:blood*; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003292:Convulsants; D054439:Ghrelin; D010433:Pentylenetetrazole