title: Involvement of anticentromere antibody in interference with oocyte meiosis and embryo cleavage.
abstract: The aim of this study was to investigate the clinical significance of anticentromere antibody (ACA) among types of antinuclear antibody (ANA) in the properties of oocytes retrieved from infertile women. The rate of metaphase II oocytes or embryo cleavage was significantly decreased in patients with positive ACA compared with patients with negative ACA, suggesting that ACA is an essential marker for flawed oocytes in infertile women with any type of ANA.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. shirota@cis.fukuoka-u.ac.jp
authors.forename: Kyoko
authors.initials: K
authors.lastname: Shirota
authors.forename: Yumi
authors.initials: Y
authors.lastname: Nagata
authors.forename: Kou
authors.initials: K
authors.lastname: Honjou
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsujioka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yoshizato
authors.forename: Shingo
authors.initials: S
authors.lastname: Miyamoto
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D016009:Chi-Square Distribution; D002970:Cleavage Stage, Ovum; D015536:Down-Regulation; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007247:Infertility, Female / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D007564:Japan; D008297:Male; D008540:Meiosis; D054315:Oocyte Retrieval; D009865:Oocytes / Q000276:immunology* / Q000473:pathology; D010062:Ovulation Induction; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; C538950:anticentromere antibody