title: Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population.
abstract: OBJECTIVE
  The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout.
  
  
  METHODS
  This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of ADRB3 gene.
  
  
  RESULTS
  Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22-3.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64/Arg64 genotype in controls compared to non-carriers (480.5 mmol/l vs 315.0 mmol/l, respectively).
  
  
  CONCLUSIONS
  ADRB3 rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.
authors.affiliation: Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Common Diseases Gout Laboratory, the Affiliated Hospital of the Medical College, Qingdao University, Qingdao, Shandong, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Dongmei
authors.initials: D
authors.lastname: Meng
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Zhaotong
authors.initials: Z
authors.lastname: Jia
authors.forename: Sirui
authors.initials: S
authors.lastname: Zhoub
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.forename: Nan
authors.initials: N
authors.lastname: Chu
authors.forename: Lin
authors.initials: L
authors.lastname: Han
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.forename: Changgui
authors.initials: C
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006073:Gout / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D014527:Uric Acid / Q000097:blood
chemical_list: D022702:Receptors, Adrenergic, beta-3; D014527:Uric Acid