title: Pathogenesis, laboratory, and clinical characteristics of Helicobacter pylori-associated immune thrombocytopenic purpura.
abstract: Idiopathic thrombocytopenic purpura (ITP) is a common autoimmune disease mediated by autoantibodies against platelet glycoproteins. This hemorrhagic disorder may be primary or secondary to various illnesses, including lymphoproliferative, autoimmune, or infectious diseases. Among the latter causes, there is increasing laboratory and clinical evidence that documents a pathogenic role of Helicobacter pylori infection in ITP. The aim of this review is to analyze the current knowledge on the pathogenic, diagnostic, clinical, and therapeutic characteristics of H. pylori-associated ITP.
authors.affiliation: Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Italy. mfranchini@ao.pr.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Mario
authors.initials: M
authors.lastname: Plebani
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.forename: Dino
authors.initials: D
authors.lastname: Veneri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
mesh_terms: D016481:Helicobacter Infections / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology* / Q000628:therapy; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D011696:Purpura, Thrombocytopenic / Q000276:immunology* / Q000382:microbiology*