title: [Tuberculous spondylodiscitis. Report of six patients].
abstract: BACKGROUND
  Tuberculous spondylodiscitis is relatively uncommon but represents the most common location of osseous tuberculosis.
  
  
  OBJECTIVE
  To describe clinical features, imaging studies and laboratory tests to establish the diagnosis in a group of patients living in Cádiz (Spain).
  
  
  METHODS
  Retrospective analysis of medical records of patients with tuberculous spondylodiscitis diagnosed between 2000 and 2009. The diagnosis was based on microorganism recovery from vertebral samples obtained by imaging guided biopsies.
  
  
  RESULTS
  Six patients with positive Mycobac-terium tuberculosis cultures from vertebral samples, were identified (10% of extra-pulmonary tuberculosis). In only 2 patients the Ziehl-Nielsen stain was positive, and histology was compatible in 4 cases. Four patients were females, their mean age was 54.3 years and the mean duration of symptoms was 7.3 months. Three patients had lumbar location and a positive Mantoux test. A soft tissue abscess was present in 4 cases. None of these patients had neurological complications. The treatment with four tuberculostatic agents (isoniazid, rifampicin, pyrazinamide and ethambutol) was effective in 5 patients.
  
  
  CONCLUSIONS
  Tuberculous spondylodiscitis may become a serious disease due to diagnostic and treatment delays. The main examinations to establish diagnosis are magnetic resonance imaging and biopsy with microbiological culture. Generally, antituberculous therapy is effective in this clinical situation.
authors.affiliation: Microbiología, Hospital Universitario Puerta del Mar, España.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Lozano
authors.forename: Lidia
authors.initials: L
authors.lastname: García-Agudo
authors.forename: Raquel
authors.initials: R
authors.lastname: Moreno
authors.forename: Nicolás
authors.initials: N
authors.lastname: Chozas
authors.forename: Pedro
authors.initials: P
authors.lastname: García-Martos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D015299:Discitis / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013030:Spain; D014399:Tuberculosis, Spinal / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents