title: The evolution of coreceptor tropism in HIV-infected patients interrupting suppressive antiretroviral therapy.
abstract: CCR5 antagonists may provide a well-tolerated switch option for patients experiencing tolerability or toxicity of their antiretroviral regimen. We analyzed stored samples from patients undergoing planned treatment interruptions for reasons other than virological failure, in order to analyze tropism evolution during fully suppressive antiretroviral therapy (ART). Two of 37 patients showed evidence of switching. Tropism switching after suppressive ART was uncommon in this cohort. Pretreatment human immunodeficiency virus (HIV) RNA tropism testing may help guide the switch to CCR5 antagonists in patients with undetectable HIV RNA.
authors.affiliation: Department of Genitourinary/HIV Medicine, Chelsea and Westminster Hospital Foundation Trust, London, United Kingdom.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Waters
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Scourfield
authors.forename: Marie
authors.initials: M
authors.lastname: Marcano
authors.forename: Brian G
authors.initials: BG
authors.lastname: Gazzard
authors.forename: Mark
authors.initials: M
authors.lastname: Bower
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
authors.forename: Justin
authors.initials: J
authors.lastname: Stebbing
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D006678:HIV / Q000472:pathogenicity*; D023581:HIV Fusion Inhibitors / Q000008:administration & dosage*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D056189:Viral Tropism; D028761:Withholding Treatment
chemical_list: D019380:Anti-HIV Agents; D023581:HIV Fusion Inhibitors