title: Mild mitochondrial uncoupling as a therapeutic strategy.
abstract: Mild mitochondrial uncoupling, or the reduction of the efficiency of energy conversion without compromising intracellular high energy phosphate levels, is a protective therapeutic strategy under many laboratory conditions. Here we discuss these conditions, which include both cell and animal models of ischemia reperfusion and complications associated with the metabolic syndrome. We also discuss drugs that promote mild mitochondrial uncoupling and naturally occurring mild mitochondrial uncoupling pathways involving free fatty acid cycling and K(+) transport.
authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil.
authors.forename: Fernanda M
authors.initials: FM
authors.lastname: Cunha
authors.forename: Camille C
authors.initials: CC
authors.lastname: Caldeira da Silva
authors.forename: Fernanda M
authors.initials: FM
authors.lastname: Cerqueira
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Kowaltowski
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D017136:Ion Transport; D024821:Metabolic Syndrome / Q000150:complications*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D015427:Reperfusion Injury / Q000503:physiopathology*; D000071256:Uncoupling Protein 1
chemical_list: D005230:Fatty Acids, Nonesterified; D007473:Ion Channels; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1; D011188:Potassium