title: Vasopressin in definite Meniere's disease with positive electrocochleographic findings.
abstract: CONCLUSIONS
  There was no evidence of a mean raised vasopressin level in 80 subjects suffering from definite Meniere's disease with positive electrocochleographic findings. There was no correlation with stress. The only group with a mildly raised level comprised those who had had a vertigo attack within a day. The most likely cause is nausea, which is the most potent trigger for vasopressin release.
  
  
  OBJECTIVE
  It has been claimed that patients with Meniere's disease have raised vasopressin levels. This has been linked with a long-standing notion that that there is a link between stress and Meniere's disease, so that an increase in vasopressin could trigger a vertigo attack.
  
  
  METHODS
  Serum vasopressin concentrations were measured in 80 patients with Meniere's disease whose diagnosis was based on conventional symptom criteria plus electrocochleographic evidence of endolymphatic hydrops.
  
  
  RESULTS
  The community mean for vasopressin is 2.2 pmol/L (SD = 2.4). For all 80 Meniere's patients the mean vasopressin concentration was 2.1 pmol/L (SD = 1.6), and 2.8 pmol/L (SD = 0.9) when the last attack was within a day.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery and Audiology, Christchurch Hospital, New Zealand. jeremy@jhornibrook.com
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hornibrook
authors.forename: Peter
authors.initials: P
authors.lastname: George
authors.forename: John
authors.initials: J
authors.lastname: Gourley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001300:Audiometry, Evoked Response; D018159:Endolymphatic Hydrops / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis* / Q000503:physiopathology*; D008875:Middle Aged; D012016:Reference Values; D014667:Vasopressins / Q000097:blood*; D055815:Young Adult
chemical_list: D014667:Vasopressins