title: Functional lateralization of sensorimotor cortex in infants measured using multichannel near-infrared spectroscopy.
abstract: Multichannel near-infrared spectroscopy (MNIRS) was used for the functional imaging of the sensorimotor cortex of newborn infants during passive knee and elbow movement under sedated sleep. Contralateral knee and elbow movement caused a marked increase in the concentration of oxyhemoglobin ([oxyHb]) from the baseline values at site within the sensorimotor area in all infants. During ipsilateral knee and elbow movement, [oxyHb] showed smaller changes, equivalent to 64 ± 23 and 66 ± 28% of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes in [oxyHb] were 16.1 ± 3.3 s for contralateral knee movement and 17.9 ± 5.7 s for contralateral elbow movement. No significant difference was noted between the mean latencies showing the maximal changes in [oxyHb] between contralateral and ipsilateral movement. There was a significant difference in the area and degree of response between the contralateral and ipsilateral movement. MNIRS could be a useful tool to understand the pathophysiology of the developing brain and monitor cortical responses in various clinical situations.
authors.affiliation: Maternal Perinatal Center, Department of Pediatrics, Kagawa University, Kitagun, Kagawa 761-0793, Japan. kusaka@med.kagawa-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusaka
authors.forename: Kenichi
authors.initials: K
authors.lastname: Isobe
authors.forename: Takanori
authors.initials: T
authors.lastname: Miki
authors.forename: Masaki
authors.initials: M
authors.lastname: Ueno
authors.forename: Kosuke
authors.initials: K
authors.lastname: Koyano
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakamura
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Konishi
authors.forename: Toru
authors.initials: T
authors.lastname: Kuboi
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kato
authors.forename: Kensuke
authors.initials: K
authors.lastname: Okubo
authors.forename: Saneyuki
authors.initials: S
authors.lastname: Yasuda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nishida
authors.forename: Susumu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D015415:Biomarkers / Q000097:blood; D001931:Brain Mapping / Q000379:methods*; D004551:Elbow Joint / Q000294:innervation*; D007839:Functional Laterality; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D007719:Knee Joint / Q000294:innervation*; D009043:Motor Activity; D009044:Motor Cortex / Q000098:blood supply / Q000254:growth & development* / Q000378:metabolism; D010108:Oxyhemoglobins / Q000378:metabolism; D011930:Reaction Time; D012890:Sleep; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D006993:Hypnotics and Sedatives; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin