title: Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia.
abstract: Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/β-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.
authors.affiliation: Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA. wallingford@mail.utexas.edu
authors.forename: John B
authors.initials: JB
authors.lastname: Wallingford
authors.forename: Brian
authors.initials: B
authors.lastname: Mitchell
mesh_terms: D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D002923:Cilia / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D021381:Protein Transport; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin