title: Percutaneous site-specific pharmacomechanical thrombolysis- thrombectomy system for bilateral acute limb ischemia.
abstract: Acute limb ischemia (ALI) remains a life-threatening condition. Studies with catheter-directed thrombolysis and percutaneous mechanical thrombectomy systems show modest improvements in mortality compared to surgery but with pitfalls of major bleeding, distal embolization, recurrent thrombosis, prolonged thrombolytic infusion and increased overall cost. We present a unique and therapeutically challenging case of bilateral acute lower limb ischemia that was managed percutaneously in one setting by a novel technique using site-specific (isolated) pharmaco-mechanical thrombolysis-thrombectomy (IPMT) system.
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Raghav
authors.initials: R
authors.lastname: Gupta
authors.forename: Archana
authors.initials: A
authors.lastname: Gautam
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Hennebry
mesh_terms: D000208:Acute Disease; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000601:surgery; D003131:Combined Modality Therapy; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D007511:Ischemia / Q000188:drug therapy* / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000188:drug therapy / Q000601:surgery; D011994:Recombinant Proteins / Q000627:therapeutic use; D017131:Thrombectomy / Q000379:methods*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator