title: Review: hCG, preeclampsia and regulatory T cells.
abstract: Human chorionic gonadotropin (hCG) is crucial for successful pregnancy. Its many functions include angiogenesis and immune regulation. Despite years of research, the etiology of preeclampsia remains unknown. Marked by insufficient trophoblast invasion and poor spiral artery remodeling, preeclampsia has also been linked to immune dysregulation. Here we discuss the roles of hCG in the context of endovascular cross-talk between trophoblasts and endothelial cells and immune tolerance. We propose that functional and glycosylation modifications of hCG may contribute to the pathogenesis of preeclampsia.
authors.affiliation: Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, RI 02905, USA.
authors.forename: W
authors.initials: W
authors.lastname: Norris
authors.forename: T
authors.initials: T
authors.lastname: Nevers
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Kalkunte
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000502:physiology*; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D011225:Pre-Eclampsia / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D011247:Pregnancy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D006063:Chorionic Gonadotropin