title: Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia.
abstract: A prospective study was performed to determine serotype distribution and antimicrobial resistance in Streptococcus pneumoniae (S. pneumoniae) from Chinese children <5 years old meeting pneumonia criteria. A total of 3865 children were enrolled and 338 S. pneumoniae isolates were obtained. The most frequent serotypes were 19F (55.6%), 19A (13.9%), 23F (10.1%), 6B (4.7%), and 14 (3.6%). The 7-, 10- and 13-valent conjugate vaccines, respectively, covered 76.3%, 76.9%, and 92.3% of isolates. Out of the isolates, six (1.8%) were penicillin resistant. All except 1 of the isolates were resistant to erythromycin. Serotype 19A showed the highest drug resistance. The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A.
authors.affiliation: Beijing Pediatric Research Institute, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Kai-Hu
authors.initials: KH
authors.lastname: Yao
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Wang
authors.forename: Gen-Ming
authors.initials: GM
authors.lastname: Zhao
authors.forename: Yue-Jie
authors.initials: YJ
authors.lastname: Zheng
authors.forename: Li
authors.initials: L
authors.lastname: Deng
authors.forename: Jing-Fu
authors.initials: JF
authors.lastname: Huang
authors.forename: Jie-Xiu
authors.initials: JX
authors.lastname: Wang
authors.forename: Rui-Zhen
authors.initials: RZ
authors.lastname: Zhao
authors.forename: Qiu-Lian
authors.initials: QL
authors.lastname: Deng
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Hu
authors.forename: Sang-Jie
authors.initials: SJ
authors.lastname: Yu
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Yang
authors.forename: Mariano
authors.initials: M
authors.lastname: Young
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D011446:Prospective Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D022242:Pneumococcal Vaccines