title: Comparison of total plasma lysophosphatidic acid and serum CA-125 as a tumor marker in the diagnosis and follow-up of patients with epithelial ovarian cancer.
abstract: OBJECTIVE
  To evaluate the role of lysophosphatidic acid (LPA) as a tumor marker in diagnosis and follow-up of patients with epithelial ovarian cancer.
  
  
  METHODS
  Eighty-seven epithelial ovarian cancer patients, 74 benign ovarian tumor patients, and 50 healthy women were enrolled in the study. Twenty-nine of 87 epithelial ovarian cancer patients were followed up for 6 cycles of paclitaxel-carboplatin chemotherapy. CA-125 and total plasma LPA levels were measured preoperatively and before each chemotherapy cycle.
  
  
  RESULTS
  Preoperative total plasma LPA and serum CA-125 levels were significantly higher in patients with epithelial ovarian cancer compared to patients with benign ovarian tumors and healthy women. Cut-off value for LPA was determined as 1.3 µmol/L and sensitivity, specificity, positive predictive value and negative predictive value were 95%, 92%, 95% and 92%, respectively. Mean total plasma LPA level of 29 patients who received chemotherapy was 7.21±6.63 µmol/L preoperatively and 6.84±6.34 µmol/L, 6.34±5.92 µmol/L, 6.14±5.79 µmol/L, 5.86±5.68 µmol/L, 5.23±5.11 µmol/L and 5.21±5.32 µmol/L in measurements held just before the 1st, 2nd, 3rd, 4th, 5th and 6th chemotherapy cycles, respectively (ANOVA, p=0.832). Total plasma LPA levels decreased slightly with chemotherapy administration and there was a weak negative correlation (Spearman, r(s)=-0.151, p=0.034), compared to a significant negative correlation in CA-125 (Spearman, r(s)=-0.596, p<0.001).
  
  
  CONCLUSIONS
  LPA is a better biomarker for diagnosis of epithelial ovarian cancer compared to CA-125. However, measurement of total plasma LPA levels during chemotherapy administration have no superiority to the serum CA-125 levels.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Istanbul, Turkey.
authors.forename: Tugan
authors.initials: T
authors.lastname: Bese
authors.forename: Merve
authors.initials: M
authors.lastname: Barbaros
authors.forename: Elif
authors.initials: E
authors.lastname: Baykara
authors.forename: Onur
authors.initials: O
authors.lastname: Guralp
authors.forename: Salih
authors.initials: S
authors.lastname: Cengiz
authors.forename: Fuat
authors.initials: F
authors.lastname: Demirkiran
authors.forename: Cevdet
authors.initials: C
authors.lastname: Sanioglu
authors.forename: Macit
authors.initials: M
authors.lastname: Arvas