title: Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature.
abstract: A case of ovarian malignant mixed mullerian tumor (MMMT) with melanocytic differentiation is described. A 74-year-old woman presented with left lower quadrant pain. Pathologic examination of the left ovary revealed a MMMT, composed predominantly of serous carcinoma (90%) with a minor sarcoma component containing focal chondroid differentiation. There was also a single focus of malignant melanoma. Immunohistochemical studies showed that the latter was positive for S-100, HMB-45, and pan-melanoma cocktail, and was negative for synaptophysin and neuron-specific enolase. To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary.
authors.affiliation: Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA. andresroma@hotmail.com
authors.forename: Andres A
authors.initials: AA
authors.lastname: Roma
authors.forename: Anais
authors.initials: A
authors.lastname: Malpica
authors.forename: Michael T
authors.initials: MT
authors.lastname: Deavers
mesh_terms: D000368:Aged; D002296:Carcinosarcoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D018200:Mixed Tumor, Mullerian / Q000378:metabolism / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*