title: Experimental infection of common warthogs (Phacochoerus africanus) and bushpigs (Potamochoerus larvatus) with classical swine fever virus. I: Susceptibility and transmission.
abstract: An incursion of classical swine fever virus (CSFV) into the domestic pig population in South Africa, identified in 2005, raised the concern that infection might spread to wildlife species and be maintained in these hosts. This study sought to determine whether two wildlife Suidae species present in South Africa, the bushpig (Potamochoerus larvatus) and the common warthog (Phacochoerus africanus), could support productive CSFV infection. Both species could be infected with CSFV and transmitted infection to in-contact animals of the same species. Viral antigen and RNA genome were detected in blood/serum and animals that survived initial infection seroconverted approximately 10-14 days post-inoculation. Viral RNA remained detectable in nasal and saliva secretions for prolonged periods until monitoring ended at 42-44 days after initial challenge. These data suggest that both Suidae species could serve to spread circulating CSFV within wild populations, with implications for disease control.
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK. h.everett@vla.defra.gsi.gov.uk
authors.forename: H
authors.initials: H
authors.lastname: Everett
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: H
authors.initials: H
authors.lastname: Crooke
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Gurrala
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Dwarka
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: B
authors.initials: B
authors.lastname: Botha
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: A
authors.initials: A
authors.lastname: Lubisi
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: A
authors.initials: A
authors.lastname: Pardini
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: S
authors.initials: S
authors.lastname: Gers
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: W
authors.initials: W
authors.lastname: Vosloo
authors.affiliation: Virology Department, Veterinary Laboratories Agency, Weybridge, New Haw, Surrey, UK ARC-OVI Transboundary Animal Diseases Programme, Private Bag X05, Onderstepoort, South Africa National Veterinary Research and Quarantine Service, Virology Division, Anyang City, Gyeonggi-do, Korea ARC-OVI Molecular Epidemiology and Diagnostics Programme, Private Bag X05, Onderstepoort, South Africa Western Cape Provincial Veterinary Laboratory, Private Bag X 5020, Stellenbosch, South Africa.
authors.forename: T
authors.initials: T
authors.lastname: Drew
mesh_terms: D000818:Animals; D006691:Classical Swine Fever / Q000635:transmission* / Q000821:virology; D006692:Classical Swine Fever Virus / Q000235:genetics / Q000502:physiology*; D004198:Disease Susceptibility / Q000662:veterinary* / Q000821:virology; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D017423:Sequence Analysis, RNA / Q000662:veterinary; D013019:South Africa; D013552:Swine; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D014759:Viral Envelope Proteins