title: Nicotinamide-independent asymmetric bioreduction of C=C-bonds via disproportionation of enones catalyzed by enoate reductases.
abstract: The asymmetric bioreduction of activated C-C-bonds catalyzed by a single flavoprotein was achieved via direct hydrogen transfer from a sacrificial 2-enone or 1,4-dione as hydrogen donor without requirement of a nicotinamide cofactor. Due to its simplicity, this system has clear advantages over conventional FAD-recycling systems.
authors.affiliation: Department of Chemistry, Organic & Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: Clemens
authors.initials: C
authors.lastname: Stueckler
authors.forename: Tamara C
authors.initials: TC
authors.lastname: Reiter
authors.forename: Nina
authors.initials: N
authors.lastname: Baudendistel
authors.forename: Kurt
authors.initials: K
authors.lastname: Faber