title: Hypouricemia and tubular transport of uric acid.
abstract: Hypouricemia is defined when a serum urate concentration is less than or equal 2.0mg/dl. Differential diagnosis is made by fractional uric acid excretion with the identification of urate transporters and intracellular proteins involved in the tubular transport of uric acid. This review examines current knowledge on uric acid tubular transport and the various clinical situations of hypouricemia.
authors.affiliation: Nephrology Department, Gran Canaria Island University Hospital, Las Palmas de Gran Canaria, Spain. noemiesparza@telefonica.net
authors.forename: N
authors.initials: N
authors.lastname: Esparza Martín
authors.forename: V
authors.initials: V
authors.lastname: García Nieto
mesh_terms: D000042:Absorption; D001692:Biological Transport; D048909:Diabetes Complications / Q000378:metabolism; D003937:Diagnosis, Differential; D005440:Fluid Therapy / Q000009:adverse effects; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008954:Models, Biological; D027361:Organic Anion Transporters / Q000235:genetics / Q000378:metabolism; D027701:Organic Cation Transport Proteins / Q000235:genetics / Q000378:metabolism; D015995:Prevalence; D015499:Renal Tubular Transport, Inborn Errors / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*; D014545:Urinary Calculi / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D019820:Xanthine / Q000652:urine; D014969:Xanthine Oxidase / Q000172:deficiency / Q000235:genetics
chemical_list: D051246:Glucose Transport Proteins, Facilitative; D027361:Organic Anion Transporters; D027701:Organic Cation Transport Proteins; C491241:SLC22A12 protein, human; C411811:SLC2A9 protein, human; D019820:Xanthine; D014527:Uric Acid; D014969:Xanthine Oxidase