title: Separated interface nerve electrode prevents direct current induced nerve damage.
abstract: Direct current, DC, can be used to quickly and reversibly block activity in excitable tissue, or to quickly and reversibly increase or decrease the natural excitability of a neuronal population. However, the practical use of DC to control neuronal activity has been extremely limited due to the rapid tissue damage caused by its use. We show that a separated interface nerve electrode, SINE, is a much safer method to deliver DC to excitable tissue and may be valuable as a laboratory research tool or potentially for clinical treatment of disease.
authors.affiliation: Stanford University, Palo Alto, CA 94305, USA. d.michael.ackermann@stanford.edu
authors.forename: D Michael
authors.initials: DM
authors.lastname: Ackermann
authors.forename: Niloy
authors.initials: N
authors.lastname: Bhadra
authors.forename: Emily L
authors.initials: EL
authors.lastname: Foldes
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Kilgore
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000009:adverse effects / Q000379:methods; D004566:Electrodes / Q000009:adverse effects; D009417:Nerve Tissue / Q000293:injuries / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries* / Q000502:physiology*; D020196:Trauma, Nervous System / Q000503:physiopathology* / Q000517:prevention & control*