title: MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption.
abstract: MR-guided transcranial focused ultrasound (FUS) has been demonstrated as a non-invasive tool for treating various brain diseases. First, FUS can thermally ablate brain tissues under real-time MR thermometry monitoring. The MRI guidance significantly improves the precision of the thermal dose deposition. Second, in conjunction with microbubble contrast agents, FUS can reversibly disrupt the blood-brain barrier for delivery of macromolecular drugs to the brain parenchyma. This offers huge potential for treating brain diseases with a much higher local drug concentration than other drug delivery methods. In this chapter, a detailed protocol of MR-guided focused ultrasound for brain thermal ablation and BBB disruption in an animal research setting is presented.
authors.affiliation: Sunnybrook Health Sciences Centre, Toronto, ON, Canada. huangyx@sri.utoronto.ca
authors.forename: Yuexi
authors.initials: Y
authors.lastname: Huang
authors.forename: Kullervo
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000818:Animals; D001812:Blood-Brain Barrier / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D002138:Calibration; D046911:Macromolecular Substances / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D045423:Microbubbles; D051381:Rats; D015203:Reproducibility of Results; D013696:Temperature; D014463:Ultrasonography
chemical_list: D046911:Macromolecular Substances