title: Neolamarckines A and B, new indole alkaloids from Neolamarckia cadamba.
abstract: Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Ahmad Kaleem
authors.initials: AK
authors.lastname: Qureshi
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Alfarius Eko
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirota
authors.forename: Khalit
authors.initials: K
authors.lastname: Mohamad
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D026121:Indole Alkaloids; D010936:Plant Extracts