title: A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening.
abstract: OBJECTIVE
  We compared the safety and effectiveness of oxytocin, dinoprostone and misoprostol for cervical priming.
  
  
  METHODS
  A total of 218 patients were enrolled to receive between one and three treatments according to physicians' options. The end points were: (1) vaginal delivery or Bishop score ≥ 8 at the end of 12 h, (2) vaginal delivery by 12 h or difference ≥ 4 between the initial and 12th hour Bishop scores. Statistical analyses were performed with ANOVA, Krustal Wallis, Scheffe, χ², Fisher, Advanced χ², and Kolmogorov-Smirnov tests. Tukey's HSD was used as a post hoc test.
  
  
  RESULTS
  Misoprostol showed statistical significance for the rate of vaginal delivery <12 h, ≥ 8 Bishop score at the end of 12 h, and cervical change of ≥ 4 Bishop scores within 12 h (p = 0.013).
  
  
  CONCLUSIONS
  Comparison between cases Bishop score <4 showed that misoprostol is more effective than dinoprostone and oxytocin. Considering Bishop score = 0 cases we calculated no statistical significance.
authors.affiliation: Division of Perinatology, Department of Obstetrics and Gynecology, Mustafa Kemal University Faculty of Medicine, Antakya, Hatay, Turkey. drsilfeler@yahoo.com
authors.forename: Dilek B
authors.initials: DB
authors.lastname: Silfeler
authors.forename: Bulent
authors.initials: B
authors.lastname: Tandogan
authors.forename: Habibe
authors.initials: H
authors.lastname: Ayvaci
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Silfeler
authors.forename: Ilter
authors.initials: I
authors.lastname: Yenidede
authors.forename: Vedat
authors.initials: V
authors.lastname: Dayicioglu
mesh_terms: D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D020070:Cervical Ripening / Q000187:drug effects*; D003692:Delayed-Action Preparations; D015232:Dinoprostone / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005865:Gestational Age; D006801:Humans; D007751:Labor, Induced; D008875:Middle Aged; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects; D010121:Oxytocin / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003692:Delayed-Action Preparations; D010120:Oxytocics; D016595:Misoprostol; D010121:Oxytocin; D015232:Dinoprostone