title: Bactericidal block copolymer micelles.
abstract: Block copolymer micelles with bactericidal properties were designed to deactivate pathogens such as E. coli bacteria. The micelles of PS-b-PAA and PS-b-P4VP block copolymers were loaded with biocides TCMTB or TCN up to 20 or 30 wt.-%, depending on the type of antibacterial agent. Bacteria were exposed to loaded micelles and bacterial deactivation was evaluated. The micelles loaded with TCN are bactericidal; bacteria are killed in less than two minutes of exposure. The most likely interpretation of the data is that the biocide is transferred to the bacteria by repeated micelle/bacteria contacts, and not via the solution.
authors.affiliation: Pulp and Paper Research Centre, McGill University, Montreal, Québec, Canada.
authors.forename: Renata
authors.initials: R
authors.lastname: Vyhnalkova
authors.forename: Adi
authors.initials: A
authors.lastname: Eisenberg
authors.forename: Theo
authors.initials: T
authors.lastname: van de Ven
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D052160:Benzothiazoles / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D053769:Nanocapsules; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013861:Thiocyanates / Q000494:pharmacology*; D014260:Triclosan / Q000494:pharmacology*
chemical_list: D000179:Acrylates; D000900:Anti-Bacterial Agents; D052160:Benzothiazoles; D008823:Micelles; D053769:Nanocapsules; D011137:Polystyrenes; D011145:Polyvinyls; D011725:Pyridines; D013861:Thiocyanates; C509855:poly(styrene-b-acrylic acid); C509607:polystyrene-block-poly(4-vinylpyridine); D014260:Triclosan; C104310:2-(thiocyanomethylthio)benzothiazole