title: Receptor signaling integration by TRP channelsomes.
abstract: Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca(2+) across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form "channelsomes", most of which function as Ca(2+) signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan. mori@sbchem.kyoto-u.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Mori
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Kajimoto
authors.forename: Akito
authors.initials: A
authors.lastname: Nakao
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kiyonaka
mesh_terms: D000818:Animals; D006801:Humans; D015398:Signal Transduction; D050051:Transient Receptor Potential Channels / Q000502:physiology*
chemical_list: D050051:Transient Receptor Potential Channels