title: Presumed tuberculous uveitis: diagnosis, management, and outcome.
abstract: OBJECTIVE
  To assess the effectiveness of anti-tuberculous treatment in patients with chronic uveitis and either active systemic or latent tuberculosis (TB) in a non-endemic community.
  
  
  METHODS
  Retrospective study of patients with chronic uveitis, non-ocular evidence of latent or active TB and no other identified cause of uveitis who underwent a 6-month course of standard anti-tuberculous chemotherapy. Response to treatment was assessed at 6 and 12 months after initiation of treatment.
  
  
  RESULTS
  A total of 27 patients were included of whom 59% were female. In all, 19 were Asian, 4 Caucasian, and 4 Black. More than half of patients had a history of contact with another person treated for TB. Inflammation resolved after chemotherapy in 70.3% of patients, 18.5% had a change in the nature of their inflammation and 11.1% had no benefit.
  
  
  CONCLUSIONS
  There were no uveitis features characteristic of TB uveitis and a wide range of manifestations was seen ranging from non-granulomatous anterior uveitis to occlusive retinal vasculitis. TB is not endemic in the United Kingdom, therefore consideration of ethnicity, immigration, and history of TB contact remain important to direct investigations. In a patient with uveitis and latent TB, a full 6-month course of anti-tuberculous chemotherapy is recommended although it may not be curative of the uveitis.
authors.affiliation: Manchester Royal Eye Hospital, Manchester, UK.
authors.forename: C
authors.initials: C
authors.lastname: Sanghvi
authors.forename: C
authors.initials: C
authors.lastname: Bell
authors.forename: M
authors.initials: M
authors.lastname: Woodhead
authors.forename: C
authors.initials: C
authors.lastname: Hardy
authors.forename: N
authors.initials: N
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D014392:Tuberculosis, Ocular / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014605:Uveitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents