title: Age-related changes of the oligodendrocytes in rat subcortical white matter.
abstract: The age-related changes, of the oligodendrocytes in rat subcortical white matter, were investigated in this study. The oligodendrocytes in subcortical white matter were labeled with anti-2',3'-cyclic nucleotide 3'-phosphodiesterase antibody (anti-CNPase antibody, a specific marker of oligodendrocytes). The total number of CNPase(+) cells was estimated with an unbiased stereological technique, the optical fractionator. In this study, we found that the total number of CNPase(+) cells in the young male rats and aged male rats was 14.4 ± 1.2 × 10(6) and 9.0 ± 1.0 × 10(6) , respectively. The total number of the CNPase(+) cells in the subcortical white matter of aged rats was significantly decreased by 37.5% when compared to young male rats. This study demonstrated that there was an aged-related decrease of the oligodendrocytes in subcortical white matter.
authors.affiliation: Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Yang
authors.forename: Shu
authors.initials: S
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Shi
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000276:immunology / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases