title: Influenza genome diversity and evolution.
abstract: The influenza viruses contain highly variable genomes and are able to infect a wide range of host species. Large-scale sequencing projects have collected abundant influenza sequence data for assessing influenza genome diversity and evolution. This work reviews current influenza sequence databases characteristics and statistics, as well as recent studies utilizing these databases to unravel influenza virus diversity and evolution. Also discussed are the newest deep sequencing methods and their applications to influenza virus research.
authors.affiliation: Research Center for Emerging Viral Infections, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan 333, Taiwan, ROC.
authors.forename: Kun-Nan
authors.initials: KN
authors.lastname: Tsai
authors.forename: Guang-Wu
authors.initials: GW
authors.lastname: Chen
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D019143:Evolution, Molecular; D014644:Genetic Variation / Q000235:genetics*; D016679:Genome, Viral; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009980:Influenza A virus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D010802:Phylogeny