title: Implication of a genetic variant at PICALM in Alzheimer’s disease patients and centenarians.
abstract: A common polymorphism (rs3851179) in the PICALM (phosphatidylinositol-binding clathrin assembly protein) gene has been recently associated with reduced risk of developing late-onset Alzheimer’s disease (LOAD). We analyzed the genotype and allele distributions of the PICALM polymorphism in 813 Italian subjects, including LOAD patients and centenarians. The segregation of the PICALM rs3851179 showed no statistically significant difference between LOAD cases and controls. The implication of a genetic variant at PICALM is confirmed for the first time, in centenarians, thus suggesting a possible role in longevity.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Florence and Centro di Ricerca,Trasferimento e Alta Formazione DENOTHE, University of Florence, Viale Morgagni, Firenze, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Piaceri
authors.forename: Silvia
authors.initials: S
authors.lastname: Bagnoli
authors.forename: Ersilia
authors.initials: E
authors.lastname: Lucenteforte
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Mancuso
authors.forename: Andrea
authors.initials: A
authors.lastname: Tedde
authors.forename: Gabriele
authors.initials: G
authors.lastname: Siciliano
authors.forename: Silvia
authors.initials: S
authors.lastname: Piacentini
authors.forename: Laura
authors.initials: L
authors.lastname: Bracco
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D034041:Monomeric Clathrin Assembly Proteins / Q000235:genetics*
chemical_list: D034041:Monomeric Clathrin Assembly Proteins; C439003:PICALM protein, human