title: ADHD in Dutch adults: heritability and linkage study.
abstract: Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental phenotype that persists into adulthood. This study investigated the heritability of inattentive and hyperactive symptoms and of total ADHD symptomatology load (ADHD index) in adults and performed linkage scans for these dimensions. Data on sibling pairs and their family members from the Netherlands Twin Register with genotype and phenotype data for inattention, hyperactivity and ADHD index (∼750 sib-pairs) were analyzed. Phenotypes were assessed with the short self-report form of the Conners' Adult ADHD Rating Scales (CAARS). Heritabilities were estimated in SOLAR under polygenic models. Genome-wide linkage scans were performed using variance components (VC) in MERLIN and MINX and model-based linkage analysis was carried out in MENDEL with empirical evaluation of the results via simulations. Heritability estimates for inattention, hyperactivity and ADHD index were 35%, 23%, and 31%, respectively. Chromosomes 18q21.31-18q21.32 (VC LOD = 4.58, p(emp)  = 0.0026) and 2p25.1 (LOD = 3.58, p(emp)  = 0.0372) provided significant evidence for linkage for inattention and the ADHD index, respectively. The QTL on chromosome 2p25.1 also showed suggestive linkage for hyperactivity. Two additional suggestive QTLs for hyperactivity and the ADHD index shared the same location on chromosome 3p24.3-3p24.1. Finally, a suggestive QTL on 8p23.3-8p23.2 for hyperactivity was also found. Heritability of inattention, hyperactivity and total ADHD symptoms is lower in adults than in children. Chromosomes 18q and 2p are likely to harbor genes that influence several aspects of adult ADHD.
authors.affiliation: Department of Biological Psychology, VU University Amsterdam, The Netherlands. v.savyuk@psy.vu.nl
authors.forename: Viatcheslav
authors.initials: V
authors.lastname: Saviouk
authors.forename: Jouke-Jan
authors.initials: JJ
authors.lastname: Hottenga
authors.forename: Eline P
authors.initials: EP
authors.lastname: Slagboom
authors.forename: Marijn A
authors.initials: MA
authors.lastname: Distel
authors.forename: Eco J C
authors.initials: EJ
authors.lastname: de Geus
authors.forename: Gonneke
authors.initials: G
authors.lastname: Willemsen
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D002877:Chromosomes, Human / Q000235:genetics; D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D006948:Hyperkinesis / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D040582:Inheritance Patterns / Q000235:genetics*; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D009426:Netherlands; D010375:Pedigree; D010641:Phenotype