title: Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation.
abstract: The naturally occurring yellow dietary diarylheptanoid curcumin (1) was converted by γ-ray to two new γ-lactones, curculactones A (2) and B (3), as well as four known transformates, erythro-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol (4), threo-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol (5), vanillic acid (6), and vanillin (7). The structures of the two new γ-lactone derivatives were elucidated on the basis of spectroscopic methods. The steroisomeric phenylpropanoids 4 and 5 exhibited significantly enhanced inhibitory activity against pancreatic lipase when compared to parent curcumin.
authors.affiliation: Department of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan, Republic of Korea. skyey7@dhu.ac.kr
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Kim
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Cheorun
authors.initials: C
authors.lastname: Jo
mesh_terms: D003474:Curcumin / Q000494:pharmacology / Q000528:radiation effects*; D005720:Gamma Rays; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D008049:Lipase / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*
chemical_list: D006139:Guaiacol; D008049:Lipase; D003474:Curcumin