title: Population variations in atherogenic dyslipidemia: A report from the HeartSCORE and IndiaSCORE Studies.
abstract: BACKGROUND
  Asian Indians and blacks have a higher risk for cardiovascular disease (CVD) events compared to whites. Atherogenic dyslipidemia, comprised of small-dense low-density lipoprotein (LDL), low high-density lipoprotein (HDL) levels, and high triglyceride (TG) levels, constitutes an important risk factor for CVD often seen in the presence of obesity. The contribution of atherogenic dyslipidemia to CVD risk across diverse racial populations is not well established.
  
  
  OBJECTIVE
  Our primary aim was to investigate the relationship between race and atherogenic dyslipidemia among whites, blacks, and Asian Indians. A secondary aim was to evaluate the association between obesity and atherogenic dyslipidemia across populations.
  
  
  METHODS
  From community-based sampling, 720 whites and 373 blacks underwent evaluation of CVD risk factors, including fasting lipoproteins. An identical protocol was administered to 205 Asian Indians from Chennai, India. Lipid profiles, including those comprising atherogenic dyslipidemia, were compared among populations.
  
  
  RESULTS
  The prevalence of small-dense LDL (pattern B) and of TG/HDL ratio >3 was greatest among Asian Indians and smallest among blacks. Compared to whites, the adjusted odds for Indians having a LDL pattern B was 2.06 (P < .001) and TG/HDL ratio >3 was 9.42 (P < .001). The adjusted odds of having LDL pattern B (odds ratio 0.39, P < 0.001) or TG/HDL ratio >3 (odds ratio 0.41, P < .001) was lower in blacks compared to whites. Among Indians, obesity had a weak association with atherogenic dyslipidemia, in contrast to the strong association among whites.
  
  
  CONCLUSIONS
  Significant population variations in atherogenic dyslipidemia exist. This may be an important component to explain population differences in cardiovascular risk.
authors.affiliation: University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 USA.
authors.forename: Suresh R
authors.initials: SR
authors.lastname: Mulukutla
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Venkitachalam
authors.forename: Oscar C
authors.initials: OC
authors.lastname: Marroquin
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Kip
authors.forename: Aryan
authors.initials: A
authors.lastname: Aiyer
authors.forename: Daniel
authors.initials: D
authors.lastname: Edmundowicz
authors.forename: Swetha
authors.initials: S
authors.lastname: Ganesh
authors.forename: Rekhi
authors.initials: R
authors.lastname: Varghese
authors.forename: Steven E
authors.initials: SE
authors.lastname: Reis