title: Abnormal circadian blood pressure pattern 1-year after kidney transplantation is associated with subsequent lower glomerular filtration rate in recipients without rejection.
abstract: Abnormal circadian blood pressure (BP) pattern is common after kidney transplantation but its relationship to long term allograft function is unclear. Of 119 kidney recipients who had ambulatory BP monitoring 1 year from transplantation, 36 patients without history of rejection were selected. Twenty-nine recipients were followed for 4 years and seven for 3 years. Iothalamate glomerular filtration rate (GFR) was obtained at 3 weeks then annually. Dippers (n = 10) had day-night systolic BP (SBP) drop (ΔSBP) of ≥10%, nondippers (n = 15) had ΔSBP 0%-9%, whereas reverse dippers (n = 11) had nocturnal rise in SBP. Compared with dippers, reverse and nondippers had a higher Banff cv score at 1 year (P = .03), lower GFR at last follow-up (73.7 ± 18.1, 55.7 ± 16.3, and 56.6 ± 21 mL/min/1.73 m(2) for dippers, non-, and reverse dippers, respectively, P = .05) and higher kidney function loss (8.0 ± 20, -9 ± 17, and 1 ± 14 mL/min/1.73 m(2) for dippers, non-, and reverse dippers, respectively, P = .02). GFR at 4 years and at last follow-up independently correlated with ΔSBP at 1 year (r = 0.46, P = .01; r = 0.34, P = .03). The current study indicates that abnormal circadian BP pattern at 1 year identifies a group of kidney recipients at risk for increased kidney function loss and lower GFR 3-4 years from transplantation.
authors.affiliation: Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA. wadei.hani@mayo.edu
authors.forename: Hani M
authors.initials: HM
authors.lastname: Wadei
authors.forename: Hatem
authors.initials: H
authors.lastname: Amer
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Griffin
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Taler
authors.forename: Mark D
authors.initials: MD
authors.lastname: Stegall
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Textor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000453:epidemiology; D001794:Blood Pressure / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D055815:Young Adult