title: Magnetically switchable bioelectrocatalytic system based on ferrocene grafted iron oxide nanoparticles.
abstract: A simple and versatile method for the introduction of redox unites onto the surface of magnetic nanoparticles has been developed based on "click" chemistry. Azide-functionalized Fe2O3 magnetic nanoparticles were synthesized and further reacted with ethynylferrocene via Cu(I)-catalyzed azide alkyne 1,3-dipolar cycloaddition (CuAAC) reaction. The functionalized magnetic nanoparticles were characterized using a powder X-ray diffractometer (XRD), transmission electron microscope (TEM), Fourier transform infrared spectroscope (FTIR), and vibrating sample magnetometer (VSM). The resulting materials have properties of both magnetism and electrochemistry, and the electrochemical properties of the nanoparticles are dependent on the features of ethynylferrocene, while the magnetic properties remain independent of ethynylferrocene. Because of the magnetism of Fe2O3 nanoparticles and the electrocatalytic activity of ferrocene unites, a recyclable, magneto-switchable bioelectrocatalytic system for glucose oxidation in the presence of glucose oxidase is developed by alternate positioning of an external magnet, and the system has a linear response for glucose biosensing over the range of 1.0-10.0 mM.
authors.affiliation: Department of Chemistry, East China Normal University , Shanghai 200062, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Peng
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Ran
authors.forename: Cong
authors.initials: C
authors.lastname: Liang
authors.forename: Li
authors.initials: L
authors.lastname: Jing
authors.forename: Siqiu
authors.initials: S
authors.lastname: Ye
authors.forename: Yuezhong
authors.initials: Y
authors.lastname: Xian
mesh_terms: D055162:Biocatalysis; D015374:Biosensing Techniques; D057930:Click Chemistry; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D005296:Ferrous Compounds / Q000737:chemistry / Q000378:metabolism*; D005947:Glucose / Q000032:analysis* / Q000378:metabolism; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism*; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D000075163:Metallocenes; D010084:Oxidation-Reduction; D013499:Surface Properties
chemical_list: D005290:Ferric Compounds; D005296:Ferrous Compounds; D058185:Magnetite Nanoparticles; D000075163:Metallocenes; C000499:ferric oxide; D005949:Glucose Oxidase; D005947:Glucose; C004998:ferrocene