title: Fluoride in the environment and its metabolism in humans.
abstract: The presence of environmental fluoride and its impact on human health is well documented. When consumed in adequate quantity, fluoride prevents dental caries, assists in the formation of dental enamels, and prevents deficiencies in bone mineralization. At excessive exposure levels, ingestion of fluoride causes dental fluorosis skeletal fluorosis, and manifestations such as gastrointestinal, neurological, and urinary problems. The distribution of fluoride in the environment is uneven and largely is believed to derive from geogenic causes. The natural sources of fluoride are fluorite, fluorapatite, and cryolite, whereas anthropogenic sources include coal burning, oil refining, steel production, brick-making industries, and phosphatic fertilizer plants, among others. Among the various sources of fluoride in the environment, those of anthropogenic origin have occasionally been considered to be major ones. The gourndwater is more susceptible to fluoride accumulation and contamination than are other environmental media, primarily because of its contact with geological substrates underneath. The high fluoride concentration in water usually reflects the solubility of fluoride (CaF₂). High concentrations are also often associated with soft, alkaline, and calcium-deficient waters. The fluoride compounds that occur naturally in drinking water are almost totally bioavailable (90%) and are completely absorbed from the gastrointestinal tract. As a result, drinking water is considered to be the potential source of fluoride that causes fluorosis. Because the bioavailability of fluoride is generally reduced in humans when consumed with milk or a calcium-rich diet, it is highly recommended that the inhabitants of fluoride-contaminated areas should incorporate calcium-rich foods in their routine diet. Guidelines for limiting the fluoride intake from drinking water have been postulated by various authorities. Such limits are designed to protect public health and should reflect all fluoride intake sources, including dietary fluoride. The toxicological risks posed by fluoride could be better understood if epidemiological surveillance for dental and skeletal fluorosis would be systematically conducted in fluoride-affected areas. Such input would greatly improve understanding of the human dose-response relationship. Such surveillance of potentially high fluoride areas is also important because it would help to delineate, much earlier, the remedial measures that are appropriate for those areas.
authors.affiliation: Regional Research Station, Central Soil Salinity Research Institute, Jail Road, Lucknow, Uttar Pradesh, India. jhask_01@yahoo.com
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Jha
authors.forename: Vinay Kumar
authors.initials: VK
authors.lastname: Mishra
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Sharma
authors.forename: Thukkaram
authors.initials: T
authors.lastname: Damodaran
mesh_terms: D005459:Fluorides / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D005461:Fluorine / Q000737:chemistry*; D005618:Fresh Water; D006801:Humans; D010944:Plants / Q000378:metabolism*; D012989:Soil Pollutants / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; D005461:Fluorine; D005459:Fluorides