title: Fate of the antifungal drug clotrimazole in agricultural soil.
abstract: Clotrimazole is a broad-spectrum antimycotic drug used for the treatment of dermatological and gynecological infections; it is incompletely broken down during sewage treatment and could potentially reach agricultural land through the application of municipal biosolids or wastewater. In the absence of any environmental fate data, we evaluated the persistence and dissipation pathways of (3)H-clotrimazole during laboratory incubations of agricultural soils. Clotrimazole was removed from a loam (time to dissipate 50% = 68 d), a sandy loam (time to dissipate 50% = 36 d), and a clay loam (time to dissipate 50% = 55 d), with formation of nonextractable residues being the major sink for (3) H. Their parent compound had no significant mineralization, as evidenced by the lack of formation of (3) H(2) O. Up to 15% of the applied radioactivity was recovered in the form of [(3)H]-(2-chlorophenyl)diphenyl methanol. The rate of clotrimazole dissipation in the loam soil did not vary with moisture content, but it was slower at a lower temperature (number of days to dissipate 50% = 275.6 d at 4°C). Addition of municipal biosolids to the loam soil did not vary the clotrimazole dissipation rate. In summary, the present study has established that clotrimazole is dissipated in soil, at rates that varied with soil texture and temperature. Clotrimazole dissipation was accompanied by the formation of nonextractable residues and detectable extractable residues of the transformation product (2-chlorophenyl)diphenyl methanol.
authors.affiliation: Agriculture and Agri-Food Canada, London, Ontario, Canada.
authors.forename: Lyne
authors.initials: L
authors.lastname: Sabourin
authors.forename: Abdul Jabbar
authors.initials: AJ
authors.lastname: Al-Rajab
authors.forename: Ralph
authors.initials: R
authors.lastname: Chapman
authors.forename: David R
authors.initials: DR
authors.lastname: Lapen
authors.forename: Edward
authors.initials: E
authors.lastname: Topp
mesh_terms: D000383:Agriculture; D000935:Antifungal Agents / Q000032:analysis* / Q000737:chemistry; D003022:Clotrimazole / Q000032:analysis* / Q000737:chemistry; D004784:Environmental Monitoring; D006207:Half-Life; D012987:Soil / Q000737:chemistry*; D012989:Soil Pollutants / Q000032:analysis* / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D012987:Soil; D012989:Soil Pollutants; D003022:Clotrimazole