title: Activity of ACHN-490 tested alone and in combination with other agents against Pseudomonas aeruginosa.
abstract: ACHN-490 was tested alone and in combination with cefepime, doripenem, imipenem, or piperacillin-tazobactam in a synergy time-kill analysis against 25 Pseudomonas aeruginosa strains with different resistance phenotypes. Each combination was synergistic against most isolates at 24 h, and antagonism was not observed. Combinations of ACHN-490 with cefepime, doripenem, imipenem, or piperacillin-tazobactam yielded synergies in ≥70% and ≥80% of strains at 6 and 12 h, respectively, and in ≥68% at 24 h.
authors.affiliation: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Pankuch
authors.forename: Gengrong
authors.initials: G
authors.lastname: Lin
authors.forename: Aya
authors.initials: A
authors.lastname: Kubo
authors.forename: Eliana S
authors.initials: ES
authors.lastname: Armstrong
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
authors.forename: Klaudia
authors.initials: K
authors.lastname: Kosowska-Shick
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D000077726:Doripenem; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D000077725:Piperacillin, Tazobactam Drug Combination; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; D000077725:Piperacillin, Tazobactam Drug Combination; D015378:Imipenem; D000077723:Cefepime; D010397:Penicillanic Acid; D000077726:Doripenem; D010878:Piperacillin