title: Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample.
abstract: Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.
authors.affiliation: Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience B.B. Brodie, University of Cagliari, Sp 8, Sestu-Monserrato, Cagliari, Italy. squassina@unica.it
authors.forename: A
authors.initials: A
authors.lastname: Squassina
authors.forename: M
authors.initials: M
authors.lastname: Manchia
authors.forename: M
authors.initials: M
authors.lastname: Costa
authors.forename: C
authors.initials: C
authors.lastname: Chillotti
authors.forename: R
authors.initials: R
authors.lastname: Ardau
authors.forename: M
authors.initials: M
authors.lastname: Del Zompo
authors.forename: G
authors.initials: G
authors.lastname: Severino
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2