title: The relationship between diabetic retinopathy and serum levels of ischemia-modified albumin and malondialdehyde.
abstract: OBJECTIVE
  To establish the correlation between ischemia-modified albumin (IMA) and malondialdehyde (MDA) and the development of diabetic retinopathy (DRP) in patients with diabetes mellitus.
  
  
  METHODS
  Seventy Type 2 diabetic patients, 35 with DRP, and 36 healthy controls were enrolled in this study. Serum IMA and MDA levels were compared statistically. Receiver operating characteristic curve analysis was also performed to calculate the value of IMA and MDA in distinguishing DRP.
  
  
  RESULTS
  Mean serum IMA levels were 0.658 ± 0.128 absorbance units in the non-DRP group, compared with 0.767 ± 0.074 absorbance units in the DRP group and 0.619 ± 0.044 absorbance units in the control group. Mean serum MDA levels were 0.325 ± 0.172 nmol/mL, 0.244 ± 0.152 nmol/mL, and 0.178 ± 0.131 nmol/mL, respectively. The differences in IMA and MDA levels were statistically significant for all groups (P < 0.05 for all). The areas under the receiver operating characteristic curves for the determination of DRP in diabetic patients were 0.789 (95% confidence interval, 0.682-0.896) for IMA and 0.3 (95% confidence interval, 0.175-0.426) for MDA.
  
  
  CONCLUSIONS
  Both serum IMA and serum MDA levels were higher in the diabetic patients compared with the control group. In particular, the high sensitivity of IMA toward DRP showed that it reflected retinal vascular complication better than MDA. Ischemia-modified albumin may be a useful marker in monitoring the risk of DRP development.
authors.affiliation: Department of Ophthalmology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. doktorademturk@yahoo.com
authors.forename: Adem
authors.initials: A
authors.lastname: Turk
authors.forename: Irfan
authors.initials: I
authors.lastname: Nuhoglu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.forename: Süleyman Caner
authors.initials: SC
authors.lastname: Karahan
authors.forename: Hidayet
authors.initials: H
authors.lastname: Erdol
authors.forename: Cihangir
authors.initials: C
authors.lastname: Erem
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D012372:ROC Curve; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D008315:Malondialdehyde