title: Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node.
abstract: Rare-earth-based nanoparticles have attracted increasing attention for their unique optical and magnetic properties. However, their application in bioimaging has been limited to photoluminescence bioimaging and magnetic resonance imaging. To facilitate their use in other bioimaging techniques, we developed a simple, rapid, efficient and general synthesis strategy for (18)F-labeled rare-earth nanoparticles through a facile inorganic reaction between rare-earth cations and fluoride ions. The (18)F-labeling process based on rare-earth elements was achieved efficiently in water at room temperature with an (18)F-labeling yield of >90% and completed within 5 min, with only simple purification by aqueous washing and centrifugation, and without the use of organic agents. The effectiveness of (18)F-labeled rare-earth nanoparticles was further evaluated by positron emission tomography (PET) imaging of their in vivo distribution and application in lymph monitoring. In addition, this strategy is proposed for the creation of a dual-model bioimaging technique, combining upconversion luminescence bioimaging and PET imaging.
authors.affiliation: Department of Chemistry & Advanced Materials Laboratory, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.forename: Mengxiao
authors.initials: M
authors.lastname: Yu
authors.forename: Sheng
authors.initials: S
authors.lastname: Liang
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chenguang
authors.initials: C
authors.lastname: Li
authors.forename: Tiantian
authors.initials: T
authors.lastname: Mou
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Yang
authors.forename: Xianzhong
authors.initials: X
authors.lastname: Zhang
authors.forename: Biao
authors.initials: B
authors.lastname: Li
authors.forename: Chunhui
authors.initials: C
authors.lastname: Huang
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li
mesh_terms: D002855:Chromatography, Thin Layer; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D008198:Lymph Nodes / Q000473:pathology*; D008674:Metals, Rare Earth / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; D008674:Metals, Rare Earth