title: Construction of a well-defined multifunctional dendrimer for theranostics.
abstract: A dendrimer-based building block for theranostics was designed. The multifunctional dendrimer is polyamide-based and contains nine azide termini, nine amine termini, and fifty-four terminal acid groups. Orthogonal functionalization of the multifunctional dendrimer with a near-infrared (NIR) cyanine dye afforded the final dendrimer that shows fluorescence in the NIR region and no toxicity toward T98G human cells. The synthetic strategy described here might be promising for fabricating the next generation of materials for theranostics.
authors.affiliation: Molecular Design Institute, New York University, New York, New York 10003, USA.
authors.forename: Cátia
authors.initials: C
authors.lastname: Ornelas
authors.forename: Ryan
authors.initials: R
authors.lastname: Pennell
authors.forename: Leonard F
authors.initials: LF
authors.lastname: Liebes
authors.forename: Marcus
authors.initials: M
authors.lastname: Weck
mesh_terms: D000588:Amines / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D009757:Nylons / Q000737:chemistry; D012995:Solubility; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014407:Tumor Cells, Cultured; D014867:Water
chemical_list: D000588:Amines; D001386:Azides; D050091:Dendrimers; D009757:Nylons; C104700:PAMAM Starburst; D014867:Water