title: Real-time contrast-enhanced ultrasound in diagnosing of focal spleen lesions.
abstract: OBJECTIVE
  To investigate the features of focal spleen lesions (FSLs) on contrast-enhanced ultrasound (CEUS) imaging.
  
  
  METHODS
  CEUS with a blot injection of SonoVue was performed in 48 patients with 75 FSLs (median diameter 2.6cm) and their perfusion characteristics were analyzed by using contrast pulse sequences (CPS) technique.
  
  
  RESULTS
  Among 19 malignant lesions (10 metastases, 7 lymphoma, 1 hemangiosarcoma, 1 epithelioid hemangioendothelioma) and 56 benign lesion (23 hemangiomas, 14 cysts, 8 infarctions, 4 splenic ruptures, 3 tuberculosis, 2 abscess, 1 pseudoaneurysm, 1 lymphangioma), 25 benign lesions were demonstrated nonenhancement. For malignancy, 50.0% (5/10) metastases and 57.1% (4/7) lymphomas were showed hypoenhancement in the arterial phase, and 18 (94.7%) of malignant lesions were hypo-enhancement in the parenchymal phase. Among 31 benign lesions with enhancement, 27 (87.1%) were showed isoenhancement or hyperenhancement in the arterial phase and 22 (71.0%) lesions were isoenhancement or hyperenhancement in the parenchymal phase. The sensitivity, specificity and accuracy of diagnosis for FSLs were 91.1%, 95.0% and 92.0% for CEUS and 75.0%, 84.2% and 77.3% respectively, for the conventional baseline ultrasound (BUS).
  
  
  CONCLUSIONS
  Real-time CEUS can provide valuable information for the diagnosis and differential diagnosis of FSLs.
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Yu
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.forename: Fangyi
authors.initials: F
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D012680:Sensitivity and Specificity; D013158:Splenic Diseases / Q000000981:diagnostic imaging*; D013160:Splenic Neoplasms / Q000000981:diagnostic imaging; D013459:Sulfur Hexafluoride; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride