title: Articular cartilage changes in patients with osteoarthritis after osteotomy.
abstract: BACKGROUND
  High tibial osteotomy (HTO) is a method used to treat medial compartmental osteoarthritis in the knee. The realignment of the knee changes the loading patterns within the joint and may allow for regeneration of articular cartilage. Magnetic resonance imaging methods can be used to assess the quality of the regenerated cartilage.
  
  
  OBJECTIVE
  Altering mechanical alignment through HTO will have predictable effects on articular cartilage, allowing cartilage preservation and possible regeneration. Quality of regenerated cartilage will be inferior to normal articular cartilage.
  
  
  METHODS
  Case series; Level of evidence, 4.
  
  
  METHODS
  Ten patients undergoing medial opening wedge HTO were evaluated using dGEMRIC methods (ie, delayed gadolinium-enhanced magnetic resonance imaging of cartilage) preoperatively and at 6 months, 1 year, and 2 years after HTO. Magnetic resonance images were evaluated by hand segmentation, and T1(Gd) relaxation times reflective of glycosaminoglycan content were determined for these regions of interest using magnetic resonance imaging analysis software.
  
  
  RESULTS
  The lateral compartment displayed higher T1(Gd) values than the medial compartment at baseline. Initially, a decrease in T1(Gd) values on the medial side were observed for all patients at 6 months and remained reduced for all but 2 participants at 1 year and 2 years after HTO. However, on the medial side after 6 months, the rate of change for T1(Gd) values shifted from being negative (-9.6 milliseconds per month) to being positive (1.7 milliseconds per month). A positive change in the T1(Gd) of the medial tibial plateau was responsible for the positive overall change in the medial compartment. There was no significant difference in the rate of change on the lateral side (P = .141), with the average over the 2-year period being a decrease of 2.28 milliseconds per month.
  
  
  CONCLUSIONS
  Medial opening wedge HTO provides subjective improvements in pain and quality of life, but the potential benefit of allowing articular cartilage preservation and possible regeneration is not well established. Results showed that after a nonweightbearing period, the rate of change in the medial compartment changes from negative to positive, indicating the potential for articular cartilage recovery secondary to an improved mechanical environment.
authors.affiliation: Sydney Orthopaedic Research Institute, Chatswood, New South Wales, Australia. dparker@sydneyortho.com.au
authors.forename: David A
authors.initials: DA
authors.lastname: Parker
authors.forename: Karen T
authors.initials: KT
authors.lastname: Beatty
authors.forename: Bruno
authors.initials: B
authors.lastname: Giuffre
authors.forename: Corey J
authors.initials: CJ
authors.lastname: Scholes
authors.forename: Myles R J
authors.initials: MR
authors.lastname: Coolican
mesh_terms: D002358:Cartilage, Articular / Q000473:pathology* / Q000502:physiology; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology / Q000601:surgery*; D010027:Osteotomy; D012038:Regeneration; D013977:Tibia / Q000601:surgery*