title: Primary CNS lymphoma in immunocompetent: a review of literature and our experience from Kashmir.
abstract: OBJECTIVE
  To study the clinicopathological aspects of primary CNS lymphoma in immunocompetent patients.
  
  
  METHODS
  Sixteen patients with primary CNS lymphoma were analyzed for their clinico-pathological characteristics and followed-up for the treatment and subsequent management in Neurosurgery, and Medical and Radiation Oncology.
  
  
  RESULTS
  The fronto-parietal region was the commonest location of CNS lymphoma; four cases of cerebellar lymphoma were seen. Our patients were relatively young with a mean age of 48 years and an age range of 35-60 years. Females outnumbered males with a ratio of 2.7:1. The commonest presentation was focal neurological-deficits and features of raised intracranial pressure. All the patients histologically had diffuse large B-cell lymphoma. Radiologically, most presented as disc-enhancing lesions. Two patients had multiple lesions. Most of the patients (10) died within a mean of 4.4 months (range 2 weeks-16 months).
  
  
  CONCLUSIONS
  Primary CNS lymphoma is seen in immunocompetent patients as well. Relapse is common after treatment and the overall prognosis is unfavorable.
authors.affiliation: Department of Pathology, SKIMS, Kashmir, 190011, India. rumanahamid@rediffmail.com
authors.forename: Rumana
authors.initials: R
authors.lastname: Makhdoomi
authors.forename: Khursheed
authors.initials: K
authors.lastname: Nayil
authors.forename: Ahmad
authors.initials: A
authors.lastname: Rayees
authors.forename: Altaf
authors.initials: A
authors.lastname: Kirmani
authors.forename: Altaf
authors.initials: A
authors.lastname: Ramzan
authors.forename: Muhammad Baba
authors.initials: MB
authors.lastname: Khalil
authors.forename: Anil
authors.initials: A
authors.lastname: Dhar
authors.forename: Syed
authors.initials: S
authors.lastname: Besina
authors.forename: Nasima
authors.initials: N
authors.lastname: Chanda
authors.forename: Abdul Rashid
authors.initials: AR
authors.lastname: Lone
authors.forename: Sumaira
authors.initials: S
authors.lastname: Qadiri
authors.forename: Muhammad
authors.initials: M
authors.lastname: Maqbool
mesh_terms: D000328:Adult; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D007121:Immunocompetence; D007194:India; D008223:Lymphoma / Q000175:diagnosis* / Q000276:immunology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed