title: Prognostic impact of the MDM2SNP309 allele in leukemia and lymphoma.
abstract: A T-to-G germline single nucleotide polymorphism in the promoter region of MDM2 (SNP309) has been reported to markedly accelerate tumor formation in humans suggesting that it may represent a powerful cancer predisposing allele. Since its first description in 2004, a large number of retrospective analyses involving a wide variety of human malignancies have been reported, showing conflicting results regarding the impact of Mdm2SNP309 status on cancer risk and response to cancer therapy. Here, we appraise the available information on the effect of Mdm2SNP309 in lymphoma and leukemia and discuss the factors that likely account for the conflicting results observed in the studies reported to date.
authors.affiliation: Department of Genetics, the University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Post
authors.affiliation: Department of Genetics, the University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Vinod
authors.initials: V
authors.lastname: Pant
authors.affiliation: Department of Genetics, the University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Hussein
authors.initials: H
authors.lastname: Abbas
authors.affiliation: Department of Genetics, the University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.|Department of Leukemia, the University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Quintás-Cardama
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D051379:Mice; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics / Q000378:metabolism*
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2