title: Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography.
abstract: We described the cases of two patients with dementia associated with motor neuron disease, the former with frontotemporal dementia (FTD) and the latter with Alzheimer's disease (AD), studied by the Pittsburgh compound B-positron emission tomography (PIB-PET). In the FTD patient, the PIB-PET revealed no amyloid accumulation in the cortex, whilst in the AD patient showed amyloid accumulation mainly in the frontal, parietal and lateral temporal lobes, besides the posterior cingulate gyrus and the precuneus. Thus, PIB-PET might facilitate the discrimination of different proteinopathies that cause neurodegenerative diseases, as dementia associated with ALS.
authors.affiliation: Department of Geriatric Medicine and Neurology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8586, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.forename: Suzuka
authors.initials: S
authors.lastname: Ataka
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamura
authors.forename: Hideki
authors.initials: H
authors.lastname: Masaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Naka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tsutada
authors.forename: Aki
authors.initials: A
authors.lastname: Nakanishi
authors.forename: Susumu
authors.initials: S
authors.lastname: Shiomi
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Takami
authors.initials: T
authors.lastname: Miki
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D013844:Thiazoles