title: Physiologically-based pharmacokinetic modelling for the reduction of animal use in the discovery of novel pharmaceuticals.
abstract: The challenges of physiologically-based pharmacokinetic (PBPK) modelling and approaches to replacing the use of animals, in order to determine drug pharmacokinetics, are discussed. Reference is made to the limitations of in vivo animal studies in drug discovery. In particular, the ways in which animal studies contribute to drug attrition during the post-preclinical phase of testing are considered.
authors.affiliation: Cyprotex Discovery Ltd, Macclesfield, UK. s.thomas@cyprotex.com
authors.forename: Simon
authors.initials: S
authors.lastname: Thomas
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D055808:Drug Discovery; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics