title: Allograft and overall survival of patients with posttransplant skin cancer.
abstract: BACKGROUND
  Little is known about the possible association between nonmelanoma skin cancer (NMSC) and allograft survival and overall patient survival.
  
  
  OBJECTIVE
  To determine the association between posttransplant NMSC and early to mid-term allograft survival and overall patient survival after kidney, liver, or heart transplantation.
  
  
  METHODS
  We retrospectively reviewed patients identified from the Organ Procurement and Transplantation Network/United Network for Organ Sharing database. The study included adult recipients of kidney (n=46,216), liver (n=8,049), and heart (n=8,519) transplants from 1996 to 2001.
  
  
  RESULTS
  Multivariate analysis showed that kidney recipients with NMSC had a significantly lower risk of allograft loss (relative risk (RR)=0.55, p<.001) and death (RR=0.55; p<.001) within 5 years of transplantation than recipients without NMSC. Significantly lower risk of death was also observed for liver recipients (RR=0.28, p<.001) and heart recipients (RR=0.25; p<.001) with NMSC.
  
  
  CONCLUSIONS
  Longer early to mid-term allograft and overall survival was seen in patients with NMSC, but long-term survival rates must be examined to determine whether mortality rates increase later for patients with NMSC, as noted in previous studies.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA. christenson.leslie@mayo.edu
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Christenson
authors.forename: Wida S
authors.initials: WS
authors.lastname: Cherikh
authors.forename: Clark C
authors.initials: CC
authors.lastname: Otley
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Salasche
authors.forename: H Myron
authors.initials: HM
authors.lastname: Kauffman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006085:Graft Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000401:mortality*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000150:complications / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate; D014481:United States; D055815:Young Adult