title: A new mechanism for blocking myeloid-derived suppressor cells by CpG.
abstract: In this issue of Clinical Cancer Research, Zoglmeier and colleagues show that CpG, via the induction of IFN-α, matures myeloid-derived suppressor cells to abrogate immune suppression in 2 murine solid tumor models.
authors.affiliation: Systems Biology and Disease Graduate Program, University of Southern California, Los Angeles, California, USA.
authors.forename: Melissa G
authors.initials: MG
authors.lastname: Lechner
authors.forename: Alan L
authors.initials: AL
authors.lastname: Epstein
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004247:DNA / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D022423:Myeloid Cells / Q000187:drug effects / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D009838:Oligodeoxyribonucleotides; D051217:Toll-Like Receptor 9 / Q000819:agonists*
chemical_list: D000970:Antineoplastic Agents; C423449:CpG ODN 1826; D009838:Oligodeoxyribonucleotides; D051217:Toll-Like Receptor 9; D004247:DNA