title: Comparative hemostasis: animal models and new hemostasis tests.
abstract: This article provides an overview of animal model systems to include their strengths and limitations in the study of hemostasis. Specific examples of spontaneous and engineered animal models are described in the context of cell-based hemostasis. The article concludes with a review of the comparative aspects of 3 laboratory assays of cell-based hemostasis: thromboelastography, thrombin generation, and flow cytometric assessment of platelet activation.
authors.affiliation: Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Marjory B
authors.initials: MB
authors.lastname: Brooks
authors.forename: Tracy
authors.initials: T
authors.lastname: Stokol
authors.forename: James L
authors.initials: JL
authors.lastname: Catalfamo
mesh_terms: D000818:Animals; D005434:Flow Cytometry / Q000662:veterinary; D005818:Genetic Engineering; D006403:Hematologic Tests / Q000379:methods / Q000639:trends / Q000662:veterinary; D006487:Hemostasis; D023421:Models, Animal; D015539:Platelet Activation; D013916:Thrombelastography / Q000662:veterinary; D013917:Thrombin / Q000378:metabolism
chemical_list: D013917:Thrombin