title: Greater hand-grip strength predicts a lower risk of developing type 2 diabetes over 10 years in leaner Japanese Americans.
abstract: OBJECTIVE
  Much is known about body composition and type 2 diabetes risk but less about body function such as strength. We assessed whether hand-grip strength predicted incident diabetes.
  
  
  METHODS
  We followed 394 nondiabetic Japanese-American subjects (mean age 51.9) for the development of diabetes. We fit a logistic regression model to examine the association between hand-grip strength at baseline and type 2 diabetes risk over 10 years, adjusted for age, sex, and family history.
  
  
  RESULTS
  A statistically significant (p = 0.008) and negative (coefficient -0.208) association was observed between hand-grip strength and diabetes risk that diminished at higher BMI levels. Adjusted ORs for a 10-pound hand-grip strength increase with BMI set at the 25th, 50th or 75th percentiles were 0.68, 0.79, and 0.98, respectively.
  
  
  CONCLUSIONS
  Among leaner individuals, greater hand-grip strength was associated with lower risk of type 2 diabetes, suggesting it may be a useful marker of risk in this population.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, United States. lwander@u.washington.edu
authors.forename: P L
authors.initials: PL
authors.lastname: Wander
authors.forename: E J
authors.initials: EJ
authors.lastname: Boyko
authors.forename: D L
authors.initials: DL
authors.lastname: Leonetti
authors.forename: M J
authors.initials: MJ
authors.lastname: McNeely
authors.forename: S E
authors.initials: SE
authors.lastname: Kahn
authors.forename: W Y
authors.initials: WY
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D000368:Aged; D001213:Asian / Q000706:statistics & numerical data; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors