title: Angiogenin induces nitric oxide release independently from its RNase activity.
abstract: Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity.
authors.affiliation: Department of Bioengineering, Imperial College London, London, UK SW7 2AZ. raphael.trouillon06@imperial.ac.uk
authors.forename: Raphaël
authors.initials: R
authors.lastname: Trouillon
authors.forename: Dong-Ku
authors.initials: DK
authors.lastname: Kang
authors.forename: Soo-Ik
authors.initials: SI
authors.lastname: Chang
authors.forename: Danny
authors.initials: D
authors.lastname: O'Hare
mesh_terms: D004563:Electrochemistry; D053595:Embryonic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D012259:Ribonuclease, Pancreatic / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D009569:Nitric Oxide; C046366:angiogenin; D012259:Ribonuclease, Pancreatic