title: In vivo assessment of bone ingrowth potential of three-dimensional e-beam produced implant surfaces and the effect of additional treatment by acid etching and hydroxyapatite coating.
abstract: The bone ingrowth potential of three-dimensional E-beam-produced implant surfaces was examined by histology and compared to a porous plasma-sprayed control. The effects of acid etching and a hydroxyapatite (HA) coating were also evaluated by histology. Specimens were implanted in the distal femur of 10 goats. Histological analysis of bone ingrowth was performed 6 weeks after implantation. The E-beam-produced surfaces showed significantly better bone ingrowth compared to the plasma-sprayed control. Additional treatment of the E-beam surface structures with a HA coating, further improved bone ingrowth potential of these structures significantly. Acid etching of the E-beam structures did not influence bone ingrowth significantly. In conclusion, the HA-coated, E-beam-produced structures are promising potential implant surfaces.
authors.affiliation: Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. l.biemond@orthop.umcn.nl
authors.forename: J Elizabeth
authors.initials: JE
authors.lastname: Biemond
authors.forename: Gerjon
authors.initials: G
authors.lastname: Hannink
authors.forename: Annemarijn M G
authors.initials: AM
authors.lastname: Jurrius
authors.forename: Nico
authors.initials: N
authors.lastname: Verdonschot
authors.forename: Pieter
authors.initials: P
authors.lastname: Buma
mesh_terms: D000143:Acids / Q000737:chemistry; D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D005269:Femur / Q000502:physiology* / Q000601:surgery / Q000648:ultrastructure; D006041:Goats; D016348:Osseointegration; D013499:Surface Properties
chemical_list: D000143:Acids; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017886:Durapatite