title: The role and therapeutic potential of prohibitin in disease.
abstract: Prohibitin 1 (PHB1), a pleiotropic protein in the cell, has been implicated in the regulation of proliferation, apoptosis, transcription, mitochondrial protein folding, and as a cell-surface receptor. This diverse array of functions of PHB1 is attributed to the cell type studied and its subcellular localization. This review discusses recent data that indicate a diverse role of PHB1 in disease pathogenesis and suggest that targeting PHB1 may be a potential therapeutic option for treatment of diseases including cancer, inflammatory bowel disease, insulin resistance/type 2 diabetes, and obesity. These diseases are associated with increased oxidative stress and mitochondrial dysfunction and therefore, the role of PHB1 in both responses will also be discussed.
authors.affiliation: Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA. arianne.theiss@baylorhealth.edu
authors.forename: Arianne L
authors.initials: AL
authors.lastname: Theiss
authors.forename: Shanthi V
authors.initials: SV
authors.lastname: Sitaraman
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000503:physiopathology*; D005786:Gene Expression Regulation; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000503:physiopathology*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology*; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology; D000091402:Prohibitins; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: C000717328:PHB protein, human; D000091402:Prohibitins; D012097:Repressor Proteins