title: A versatile sugar transferase makes the cut.
abstract: The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.
authors.affiliation: Laboratory of Cellular and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-0851, USA. jah@helix.nih.gov
authors.forename: John A
authors.initials: JA
authors.lastname: Hanover