title: [Research on cellular immune function of patients with lung cancer before and after operation].
abstract: BACKGROUND
  To explore the perioperative changes of T subsets and NK cell and analyze the related factors in patients with lung cancer.
  
  
  METHODS
  The T subsets and NK cell from peripheral blood of 60 patients with lung cancer, 15 patients with lung benign tumor and 15 healthy people were detected by immunofluorescence. These indexes of the patients with lung cancer were detected also at postoperative 2nd, 7th, 14th and 28th days.
  
  
  RESULTS
  1.There were significant differences in the indexes between the lung cancer group and the groups of lung benign tumor and normal people except for CD8+ (P < 0.05). 2.At postoperative 2nd day CD3+, CD4+, CD4+/CD8+ and NK cell of the patients with lung cancer were decreased and CD8+ was increased significantly than those before operation (P < 0.05). During postoperative 1 to 2 weeks, all indexes had recovered basically to the preoperative level. At postoperative 28th day, CD3+, CD4+ , CD4+/CD8+ and NK cell were increased and CD8+ was decreased than those before operation (P < 0.05). 3. There was significant difference in the indexes among preoperative stage IIIA, IIIB and IB, and between preoperative N2 diseases and N0 group (P < 0.05). There was significant difference between the groups of radical and palliative operation and the group of thoracic exploration at postoperative 28th day (P < 0.05). There was significant difference in T subsets between the groups of blood transfusion and non-transfusion at postoperative 14th day (P < 0.05).
  
  
  CONCLUSIONS
  The cellular immune function of the patients with lung cancer was lower than that of the patients with lung benign tumor and normal people. The perioperative immunity of patients with lung cancer decreases after operation and increases later. TNM stage and lymph node metastasis are relative to preoperative but not postoperative immunity. There is no significant correlation between cellular immune function and pathological type of the tumor. Radical and palliative operations can both significantly increase the patients' cellular immune function. Therefore the palliative operation is better than thoracic exploration. Blood transfusion can depress the immune function of the patients, so it is better to avoid perioperative blood transfusion.
authors.affiliation: Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300051, P.R.China.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.forename: Fuyuan
authors.initials: F
authors.lastname: Zhao
authors.forename: Lianxiang
authors.initials: L
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Xueqin
authors.initials: X
authors.lastname: Wang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Cai
authors.forename: Cuiying
authors.initials: C
authors.lastname: Zheng
authors.forename: Tieshuan
authors.initials: T
authors.lastname: Tian
authors.forename: Xike
authors.initials: X
authors.lastname: Lu
authors.forename: Kuojian
authors.initials: K
authors.lastname: Wang