title: Proclaiming fate in the early mouse embryo.
abstract: In the mouse embryo, the first differences between cells that result in distinct lineages have long been thought to arise only as a consequence of differential cell positioning at relatively late preimplantation stages. Differences in Oct4 transcription factor kinetics between cells at the 4-8-cell stage are now shown to be predictive of future lineages, providing further evidence for much earlier initiation of cell fate decisions.
authors.affiliation: Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, UK. m.zernicka-goetz@gurdon.cam.ac.uk
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zernicka-Goetz
mesh_terms: D000818:Animals; D019070:Cell Lineage; D004622:Embryo, Mammalian / Q000166:cytology*; D051379:Mice; D050814:Octamer Transcription Factor-3 / Q000378:metabolism
chemical_list: D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse