title: Emergence of disseminated infections due to Geosmithia argillacea in patients with chronic granulomatous disease receiving long-term azole antifungal prophylaxis.
abstract: We report two cases of invasive infections due to Geosmithia argillacea, an emerging mold, in patients with chronic granulomatous disease receiving prolonged azole antifungal prophylaxis. One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon.
authors.affiliation: Service de Parasitologie-Mycologie, CHU de Nancy, Hôpital Brabois, 11 allée du Morvan, 54511 Vandoeuvre-les-Nancy, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Machouart
authors.forename: Dea
authors.initials: D
authors.lastname: Garcia-Hermoso
authors.forename: Alexandre
authors.initials: A
authors.lastname: Rivier
authors.forename: Noura
authors.initials: N
authors.lastname: Hassouni
authors.forename: Emilie
authors.initials: E
authors.lastname: Catherinot
authors.forename: Alexandra
authors.initials: A
authors.lastname: Salmon
authors.forename: Anne
authors.initials: A
authors.lastname: Debourgogne
authors.forename: Hélène
authors.initials: H
authors.lastname: Coignard
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Bougnoux
authors.forename: Stéphane
authors.initials: S
authors.lastname: Blanche
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000038:Abscess / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D001393:Azoles / Q000008:administration & dosage*; D000077336:Caspofungin; D018890:Chemoprevention / Q000379:methods*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D054714:Echinocandins / Q000008:administration & dosage; D032641:Eurotiales / Q000145:classification / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000188:drug therapy*; D006651:Histocytochemistry; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage; D055666:Lipopeptides; D008297:Male; D008853:Microscopy; D008969:Molecular Sequence Data; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology; D009281:Naphthalenes / Q000008:administration & dosage; D017422:Sequence Analysis, DNA; D000077291:Terbinafine; D014230:Triazoles / Q000008:administration & dosage
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D014230:Triazoles; C101425:posaconazole; D007371:Interferon-gamma; D000077336:Caspofungin; D000077291:Terbinafine