title: [A serious "acetaldehyde syndrome" compounded by dopamine].
abstract: Disulfiram is commonly used in the treatment of alcohol dependence. It induces aversive symptoms after alcohol ingestion: the "acetaldehyde syndrome". Most often "acetaldehyde syndrome" is moderate but severe life-threatening symptoms may occur in specific circumstances. We report the case of a serious "acetaldehyde syndrome" with shock compounded by the initial administration of dopamine. Discussion clarifies the pathophysiology and develops the therapeutic management.
authors.affiliation: Unité de réanimation polyvalente, hôpital Maison-Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Amireche
authors.forename: J-S
authors.initials: JS
authors.lastname: Petit
authors.forename: E
authors.initials: E
authors.lastname: Bankole
authors.forename: A
authors.initials: A
authors.lastname: Fournet-Fayard
authors.forename: M
authors.initials: M
authors.lastname: Appriou
authors.forename: A
authors.initials: A
authors.lastname: Leon
mesh_terms: D000079:Acetaldehyde / Q000009:adverse effects*; D000427:Alcohol Deterrents / Q000009:adverse effects*; D000435:Alcoholic Intoxication / Q000150:complications; D000437:Alcoholism / Q000150:complications / Q000188:drug therapy; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000009:adverse effects*; D002492:Central Nervous System Depressants / Q000009:adverse effects; D004221:Disulfiram / Q000009:adverse effects*; D004298:Dopamine / Q000009:adverse effects*; D004562:Electrocardiography; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000628:therapy; D008297:Male; D008875:Middle Aged
chemical_list: D000427:Alcohol Deterrents; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D002316:Cardiotonic Agents; D002492:Central Nervous System Depressants; D000431:Ethanol; D000079:Acetaldehyde; D004221:Disulfiram; D004298:Dopamine