title: The α-sheet: a missing-in-action secondary structure?
abstract: The α-sheet has been speculated to play a role as a toxic conformer in amyloid diseases. However, except for relatively short fragments, its detection has remained elusive. Here, we present molecular dynamics simulations that support the existence of the α-sheet as a stable, metastable, or long-lived secondary structure in polyglutamine and, to a lesser extent, in polyasparagine aggregates.
authors.affiliation: Center for High Performance Simulations, North Carolina State University, Raleigh, North Carolina 27695, USA.
authors.forename: Volodymyr
authors.initials: V
authors.lastname: Babin
authors.forename: Christopher
authors.initials: C
authors.lastname: Roland
authors.forename: Celeste
authors.initials: C
authors.lastname: Sagui
mesh_terms: D056004:Molecular Dynamics Simulation; D010455:Peptides / Q000737:chemistry; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides; C097188:polyglutamine; C045164:polyasparagine