title: Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease.
abstract: BACKGROUND
  Increasing evidence suggests that innate immune system may have a key role in the pathogenesis of the inflammatory bowel disease (IBD). Bactericidal/permeability increasing protein (BPI) has an important role in the recognition and neutralization of gram-negative bacteria by host innate immune system. The polymorphism on BPI gene called Lys216Glu is on the suspected list of IBD pathogenesis.
  
  
  METHODS
  We studied the Lys216Glu polymorphism on BPI gene, in a Turkish IBD patient population. A total of 238 IBD patients; 116 Crohn's disease (CD) and 122 ulcerative colitis (UC), besides 197 healthy controls were included in this study.
  
  
  RESULTS
  The Glu/Glu genotype and allele frequencies were found to be statistically higher compared to healthy control group not only in CD patients [P: 0.03, OR: 1.87 (CI 95% 1.02-3.42) and P: 0.00001 (OR: 2.07 CI 95% 1.47-2.91) respectively] but also in UC patients [P: 0.0002, OR: 2.71 (CI 95% 1.53-4.80) and P: 0.00002 (OR: 2.71 CI 95% 1.53-4.80) respectively].
  
  
  CONCLUSIONS
  BPI polymorphism (Lys216Glu) is associated both to CD and UC. Our findings differ from the two Western European studies; one without any association and the other indicating an association only with CD. Our study is the first one reporting a novel association between BPI gene mutation (Lys216Glu) and UC.
authors.affiliation: Marmara University Faculty of Medicine, Gastroenterology Department, Istanbul, Turkey. drhakanakin@hotmail.com
authors.forename: Hakan
authors.initials: H
authors.lastname: Akin
authors.forename: Gülgün
authors.initials: G
authors.lastname: Tahan
authors.forename: Filiz
authors.initials: F
authors.lastname: Türe
authors.forename: Fatih
authors.initials: F
authors.lastname: Eren
authors.forename: Ozlen
authors.initials: O
authors.lastname: Atuğ
authors.forename: Veysel
authors.initials: V
authors.lastname: Tahan
authors.forename: Ismail
authors.initials: I
authors.lastname: Hamzaoğlu
authors.forename: Neşe
authors.initials: N
authors.lastname: Imeryüz
authors.forename: Nurdan
authors.initials: N
authors.lastname: Tözün
authors.forename: Hulya Over
authors.initials: HO
authors.lastname: Hamzaoglu
mesh_terms: D000086:Acetazolamide; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023181:Antimicrobial Cationic Peptides / Q000235:genetics*; D001798:Blood Proteins / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; C021623:bactericidal permeability increasing protein; D000086:Acetazolamide