title: Effects of a supra-sustained gelatin-milk protein diet compared with (supra-)sustained milk protein diets on body-weight loss.
abstract: Diets higher in protein content result in increased satiety and energy expenditure. In the short term, gelatin showed stronger hunger suppression and less subsequent energy intake compared with other proteins. The present study investigated whether a supra-sustained gelatin-milk protein (GMP) diet promotes weight loss compared with a sustained milk protein (SMP) diet and a supra-sustained milk protein (SSMP) diet during an 8-week diet period. A total of seventy-two healthy subjects (31·2 (sd 4·8) kg/m2; 43 (sd 10) years) followed one of the three diets in a subject-specific amount: SMP, SSMP or GMP diet. During weeks 1-4, energy intake was 100 % of individual energy requirement: 10, 40 and 50 % of energy (En %) as protein, fat and carbohydrate, respectively (SMP diet), and 20, 30 and 50 En % as protein, fat and carbohydrate, respectively (SSMP diet or GMP diet). During weeks 5-8, energy intake was 33 % of individual energy requirement: 30, 35 and 35 En % as protein, fat and carbohydrate, respectively (SMP diet), and 60, 5 and 35 En % as protein, fat and carbohydrate, respectively (SSMP diet or GMP diet). Thus, absolute protein intake was kept constant throughout per subject. Significant decreases in BMI (P < 0·0001) were similar between the GMP ( - 1·7 (sd 0·5) kg/m2) and the SMP ( - 2·1 (sd 0·8) kg/m2) and SSMP ( - 1·6 (sd 0·5) kg/m2) diets. Decreases in fat-free mass (FFM), fat mass (FM) and FM %, and increases in FFM % were similar between the GMP and both control diets. Changes in RQ differed (P < 0·05) between the GMP ( - 0·01 (sd 0·06)) and SSMP ( - 0·04 (sd 0·04)) diets. Changes in HDL concentrations differed (P < 0·05) between the GMP ( - 0·21 (sd 0·18) mmol/l) and the SMP and SSMP diets ( - 0·08 (sd 0·18) mmol/l and - 0·09 (sd 0·26) mmol/l, respectively). In conclusion, a gelatin-milk protein diet does not induce more beneficial effects during an 8-week weight-loss period compared with a SMP or SSMP diet.
authors.affiliation: Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
authors.forename: Ananda
authors.initials: A
authors.lastname: Hochstenbach-Waelen
authors.forename: Stijn
authors.initials: S
authors.lastname: Soenen
authors.forename: Klaas R
authors.initials: KR
authors.lastname: Westerterp
authors.forename: Margriet S
authors.initials: MS
authors.lastname: Westerterp-Plantenga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition; D004038:Diet, Reducing; D004044:Dietary Proteins / Q000032:analysis / Q000494:pharmacology*; D004734:Energy Metabolism / Q000502:physiology; D005780:Gelatin / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D008894:Milk Proteins / Q000737:chemistry* / Q000494:pharmacology*; D010349:Patient Compliance; D015431:Weight Loss / Q000187:drug effects*; D055815:Young Adult
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins; D005780:Gelatin