title: [Mutant prevention concentrations of garenoxacin against Streptococcus pneumoniae isolates from otorhinolaryngological infections].
abstract: The minimum inhibitory concentrations (MICs) and the mutant prevention concentrations (MPCs) of garenoxacin (GRNX), were compared to those of levofloxacin (LVFX), and moxifloxacin (MFLX) against 78 Streptococcus pneumoniae isolates from otorhinolaryngological infections in Japan during the period January 2007 to June 2007. The MIC and MPC for 90% of the isolates (MIC90 and MPC90) of GRNX were 0.06 and 0.12 microg/mL, respectively, and were the lower values than LVFX and MFLX MIC90s and MPC90s. The ratios of MPC/MIC of GRNX were the lower values than those of LVFX and MFLX.
authors.affiliation: Department of Otolaryngology, Second Hospital, Fujita Health University.
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kurono
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Tadao
authors.initials: T
authors.lastname: Nishimura
authors.forename: Shunkichi
authors.initials: S
authors.lastname: Baba
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Harabuchi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamanaka
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ikeda
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D064704:Levofloxacin; D000077266:Moxifloxacin; D009154:Mutation; D015242:Ofloxacin / Q000494:pharmacology; D010038:Otorhinolaryngologic Diseases / Q000382:microbiology* / Q000517:prevention & control*; D011008:Pneumococcal Infections / Q000382:microbiology* / Q000517:prevention & control*; D011804:Quinolines / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D064704:Levofloxacin; D015242:Ofloxacin; D000077266:Moxifloxacin; C419689:garenoxacin