title: Influence of endothelial nitric oxide synthase polymorphisms in psoriasis risk.
abstract: Nitric oxide (NO) is a potent regulator of keratinocyte growth and differentiation that has been implicated in the pathogenesis of psoriasis (Ps). The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease. The aim of this study was to determine whether the above-mentioned NOS3 variants contributed to the risk of Ps, and were associated with the risk for HT and CAD in these patients. A total of 368 patients with chronic plaque Ps and 400 healthy controls were genotyped for the NOS3 -786 T/C, intron 4 VNTR, and Glu298Asp polymorphisms. Carriers of the -786 C allele were significantly more frequent among the patients (p < 0.001). Carriers of the 4-repeats allele (45 + 44 genotypes) were also more frequent a (p < 0.001). No significant difference was found for the Glu298Asp polymorphism. None of the NOS3 variants was associated with Ht and CAD in our population. In conclusion, NOS3 gene polymorphism would be risk factors for developing Ps.
authors.affiliation: Dermatology II Department, University Hospital Central of Asturias (HUCA), 33007, Oviedo, Spain. pabcoto@yahoo.es
authors.forename: Pablo
authors.initials: P
authors.lastname: Coto-Segura
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Albert
authors.initials: A
authors.lastname: Mas-Vidal
authors.forename: Blanca
authors.initials: B
authors.lastname: Morales
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Marta
authors.initials: M
authors.lastname: Díaz
authors.forename: Belén
authors.initials: B
authors.lastname: Alonso
authors.forename: Jorge
authors.initials: J
authors.lastname: Santos-Juanes
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D004252:DNA Mutational Analysis; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000150:complications / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D012306:Risk; D020080:Tandem Repeat Sequences / Q000235:genetics
chemical_list: D009569:Nitric Oxide; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III