title: Allergy to human insulin and specific immunotherapy with glargine; case report with review of literature.
abstract: Insulin has an important role in the treatment of diabetic patients. Further, it can result in undesirable side effects. One of the problems that are associated with insulin therapy is allergic reactions. Although insulin allergy is uncommon, especially in patients with type-2 diabetes, but when it occurs, its management can be difficult. We report a 55-year-old woman with poorly controlled type-2 diabetes and insulin allergy. She revealed hypersensitivity reactions including urticaria and respiratory symptoms, immediately after injection. So, specific immunotherapy with other insulin preparations was done. Finally, after specific immunotherapy, we were able to treat the patient with short- and long-acting analogs successfully.
authors.affiliation: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Shariati Hospital, Iran. sh_hasani@sina.tums.ac.ir
authors.forename: S
authors.initials: S
authors.lastname: Hasani-Ranjbar
authors.forename: M R
authors.initials: MR
authors.lastname: Fazlollahi
authors.forename: A
authors.initials: A
authors.lastname: Mehri
authors.forename: B
authors.initials: B
authors.lastname: Larijani
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007328:Insulin / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting / Q000627:therapeutic use*; D008875:Middle Aged; D013379:Substrate Specificity / Q000276:immunology
chemical_list: D007328:Insulin; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine