title: Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls.
abstract: Herein, a new copper-catalysed strategy for the synthesis of rare nitrogen-linked seven-, eight- and nine-membered biaryl ring systems is described. It is proposed that the reaction proceeds through a highly activated intramolecularly co-ordinated copper catalyst. The process is technically simple, proceeds under relatively mild conditions, displays a broad substrate scope and forms biologically valuable products that are difficult to synthesise by other methods. We envisage that this methodology will prove useful in a wide synthetic context, with possible applications in both target-oriented and diversity-oriented synthesis.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
authors.forename: Jayne L
authors.initials: JL
authors.lastname: Kenwright
authors.forename: Warren R J D
authors.initials: WR
authors.lastname: Galloway
authors.forename: David T
authors.initials: DT
authors.lastname: Blackwell
authors.forename: Albert
authors.initials: A
authors.lastname: Isidro-Llobet
authors.forename: James
authors.initials: J
authors.lastname: Hodgkinson
authors.forename: Lars
authors.initials: L
authors.lastname: Wortmann
authors.forename: Steven D
authors.initials: SD
authors.lastname: Bowden
authors.forename: Martin
authors.initials: M
authors.lastname: Welch
authors.forename: David R
authors.initials: DR
authors.lastname: Spring
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D002861:Chromobacterium / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004926:Escherichia coli / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D003300:Copper; D009584:Nitrogen