title: The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword.
abstract: Since its first description more than 30 years ago p53 has become a paradigm for a protein with versatile functions. P53 sensitizes a large variety of genetic alterations and has been entitled the guardian of the genome. Stabilization of p53 upon DNA damage is accompanied by a complex pattern of modifications, which ascertain the cellular response either in the direction of a reversible or irreversible cell cycle arrest or programmed cell death. More recently it became evident that p53 also responds to non-genotoxic cell stress, in particular if ribosome biogenesis is affected.
authors.affiliation: Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.|current address: Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.
authors.forename: Michael
authors.initials: M
authors.lastname: Hölzel
authors.affiliation: Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.
authors.forename: Kaspar
authors.initials: K
authors.lastname: Burger
authors.affiliation: Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.
authors.forename: Bastian
authors.initials: B
authors.lastname: Mühl
authors.affiliation: Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Orban
authors.affiliation: Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Kellner
authors.affiliation: Department of Molecular Epigenetics, Center of Integrated Protein Science (CIPSM), Helmholtz Center Munich, Munich, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Eick
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004249:DNA Damage; D006801:Humans; D012269:Ribosomal Proteins / Q000737:chemistry / Q000378:metabolism*; D012270:Ribosomes / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012269:Ribosomal Proteins; D016159:Tumor Suppressor Protein p53