title: The anti-plaque efficacy of a novel stannous-containing sodium fluoride dentifrice: a randomized and controlled clinical trial.
abstract: OBJECTIVE
  To evaluate the anti-plaque efficacy of a novel stannous-containing sodium fluoride dentifrice compared to a negative control regular anti-caries dentifrice and a positive control marketed triclosan-containing dentifrice.
  
  
  METHODS
  This was a randomized and controlled, single-center, double-blind, three-treatment, three-period, crossover clinical trial in generally healthy adults. A prophylaxis was followed by three 4-day treatment periods of limited brushing, each separated by an approximate 7-day washout phase. Subjects used the test dentifrice on Days 0-3 of each period according to their randomly assigned sequence; either Crest Cavity Protection (negative control); an experimental stannous-containing sodium fluoride dentifrice; or a marketed triclosan positive control (Colgate Total). A dental polishing was given at Day 0 of each treatment period, and subjects brushed the lingual surfaces only and then swished the entire dentition with a dentifrice slurry twice daily under supervision through Day 3. At baseline and Day 4 of each treatment period, plaque levels were assessed via the Turesky Modification of the Quigley-Hein Plaque Index (TMQHPI).
  
  
  RESULTS
  Twenty-eight fully evaluable subjects completed the trial. Both the experimental and positive control dentifrices provided significantly lower mean whole mouth TMQHPI plaque scores after treatment compared to the negative control: 11.4% lower for the experimental stannous-containing dentifrice and 8.4% for Colgate Total (P< 0.0001). The experimental stannous-containing dentifrice group resulted in directionally lower whole mouth plaque scores when compared to Colgate Total (P= 0.07). The experimental stannous-containing dentifrice had significantly lower mean plaque scores post-treatment at lingual sites compared with Total (P= 0.0355). All dentifrices were well-tolerated.
authors.affiliation: Procter & Gamble Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. he.t@pg.com
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Lily
authors.initials: L
authors.lastname: Sun
authors.forename: Sarah
authors.initials: S
authors.lastname: Li
authors.forename: Nelson
authors.initials: N
authors.lastname: Ji
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000627:therapeutic use; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008298:Maleates / Q000627:therapeutic use; D008875:Middle Aged; D010710:Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D011145:Polyvinyls / Q000627:therapeutic use; D012824:Silicic Acid / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D017971:Tin Compounds / Q000627:therapeutic use; D014002:Tin Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D014100:Toothpastes / Q000627:therapeutic use; D014260:Triclosan / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; C510825:Crest Pro-Health Dentifrice; D003802:Dentifrices; D008298:Maleates; D010710:Phosphates; D011145:Polyvinyls; D017971:Tin Compounds; D014002:Tin Fluorides; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D012824:Silicic Acid; C023599:stannous chloride; D014260:Triclosan; D012969:Sodium Fluoride