title: Increased liver fat content and unfavorable glucose profiles in subjects without diabetes.
abstract: BACKGROUND
  Liver fat content (LFC) in subjects without diabetes may be correlated with adverse glucose profiles.
  
  
  METHODS
  LFC was measured by (1)H magnetic resonance spectroscopy in 47 healthy subjects, 35 of whom also completed continuous glucose monitoring (CGM) studies. Subjects were divided into two groups according to LFC, and between-group comparisons of glucose profiles were made.
  
  
  RESULTS
  The median LFC value was 3.8% (interquartile range, 2.4-7.6%), and 29.8% of the subjects had LFC values ≥ 5.5%. LFC was positively correlated with triglyceride, aspartate aminotransferase, γ-glutamyltransferase, fasting C-peptide, fasting insulin, insulin concentration at 120 min, area under the time-concentration curve for insulin, and change in insulin from 0 to 30 min, homeostatic model assessment of insulin resistance, fasting plasma glucose, nocturnal mean blood glucose concentration (MBG) (all P < 0.05). The 35 CGM profiles revealed that nocturnal MBG was higher in subjects with LFC ≥ 3.8% (P < 0.05). In subjects with LFC ≥ 5.5%, both diurnal and nocturnal MBG values were elevated compared with subjects with lower LFC (P < 0.05). LFC was the strongest predictive factor of nocturnal MBG.
  
  
  CONCLUSIONS
  Even modestly elevated LFC was associated with unfavorable glucose profiles in subjects without diabetes.
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Bian
authors.forename: Hongmei
authors.initials: H
authors.lastname: Yan
authors.forename: Mengsu
authors.initials: M
authors.lastname: Zeng
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Rao
authors.forename: Xiuzhong
authors.initials: X
authors.lastname: Yao
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D002681:China / Q000453:epidemiology; D002940:Circadian Rhythm; D042241:Early Diagnosis; D005234:Fatty Liver / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011236:Prediabetic State / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D002097:C-Reactive Protein