title: The potential antioxidant activity of 2,3-dihydroselenophene, a prototype drug of 4-aryl-2,3-dihydroselenophenes.
abstract: Here we present our results in palladium cross-coupling reaction of aryl boronic acids with 4-iodo-2,3-dihydroselenophene derivatives. The cross-coupled products were obtained in satisfactory yields. A dehydrogenation of 4,5-diphenyl-2,3-dihydroselenophene was activated by DDQ and the 2,3-diarylselenophene was obtained in good yield. Regarding the antioxidant activity, the selenophene derivative 3a was effective in counteracting lipid and protein oxidation as well as scavenging ABTS radical. The findings of the present study indicate that 3a is a prototype for future drug development programs to treat disorders mediated by reactive oxygen species.
authors.affiliation: Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios, CCNE, UFSM, Santa Maria, Rio Grande do Sul, CEP 97105-900, Brazil.
authors.forename: Ricardo F
authors.initials: RF
authors.lastname: Schumacher
authors.forename: Alisson R
authors.initials: AR
authors.lastname: Rosário
authors.forename: Ana C G
authors.initials: AC
authors.lastname: Souza
authors.forename: Carmine I
authors.initials: CI
authors.lastname: Acker
authors.forename: Cristina W
authors.initials: CW
authors.lastname: Nogueira
authors.forename: Gilson
authors.initials: G
authors.lastname: Zeni
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000737:chemistry; D008297:Male; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: C558238:2,3-dihydroselenophene; D000975:Antioxidants; D003432:Cross-Linking Reagents; D016566:Organoselenium Compounds