title: T-cell subset regulation in atopy.
abstract: Presentation of processed allergen by antigen-presenting cells to T-helper (Th) lymphocytes, which is influenced costimulatory signals, cytokines, chemokines, and regulatory T cells (Tregs), determines the development of different types of T-cell immunity. The discovery of Tregs revolutionized the primary concepts of immune regulation interpreted within the framework of a binary Th1/Th2 paradigm. Tregs play a central role in the maintenance of peripheral homeostasis, the establishment of controlled immune responses, and the inhibition of allergen-specific effector cells. Recently, some other T-cell subsets appeared, including Th17 and Th9 cells, which control local tissue inflammation through upregulation of proinflammatory cytokines and chemokines. This review aims to discuss our understanding of the T-cell subset reciprocal interaction in atopy.
authors.affiliation: Department of Clinical Immunology, Wroclaw Medical University, T. Chalubinskiego 5, 50-368, Wroclaw, Poland. mjutel@ak.am.wroc.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Jutel
authors.forename: Cezmi A
authors.initials: CA
authors.lastname: Akdis
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007111:Immunity, Cellular; D007249:Inflammation / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D000485:Allergens; D016207:Cytokines