title: Catheter-related candidemia caused by Candida haemulonii in a patient in long-term hospital care.
abstract: Candida haemulonii, one of the non-albicans Candida species, is an emerging yeast pathogen that is known to be resistant to amphotericin B and other antifungal agents such as azoles. These anti-fungal agents have often been associated with clinical treatment failure, so no treatment regimen has been clearly established for invasive C. haemulonii infections. We investigated a catheter-related infection of C. haemulonii candidemia in an adult patient in long-term hospital care. In the early stages, the candidemia remained persistent despite treatment with fluconazole. However, after changing the antifungal agent to caspofungin, the candidemia was resolved. Fluconazole and amphotericin B are not reliable empirical antifungal agents for invasive C. haemulonii infections, as shown in previous case reports. An echinocandin such as caspofungin may be an appropriate empirical choice of antifungal agent for an invasive C. haemulonii infection.
authors.affiliation: Division of Infectious Disease, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Sunyong
authors.initials: S
authors.lastname: Kim
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Su Yeon
authors.initials: SY
authors.lastname: Moon
authors.forename: Mi Suk
authors.initials: MS
authors.lastname: Lee
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Jun Seong
authors.initials: JS
authors.lastname: Son
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology*; D000077336:Caspofungin; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D054714:Echinocandins / Q000627:therapeutic use; D015725:Fluconazole / Q000627:therapeutic use; D006761:Hospitals; D006801:Humans; D055666:Lipopeptides; D008134:Long-Term Care; D008297:Male; D010802:Phylogeny
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000666:Amphotericin B; D015725:Fluconazole; D000077336:Caspofungin