title: Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa.
abstract: Four new depsipeptides, mirabamides E-H (1-4), and the known depsipeptide mirabamide C (5) have been isolated from the sponge Stelletta clavosa, collected from the Torres Strait. The planar structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The absolute configurations were established by the advanced Marfey's method, NMR, and GC-MS. The four new compounds all showed strong inhibition of HIV-1 in a neutralization assay with IC(50) values of 121, 62, 68, and 41 nM, respectively.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Lu
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Van Wagoner
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Harper
authors.forename: Heather L
authors.initials: HL
authors.lastname: Baker
authors.forename: John N A
authors.initials: JN
authors.lastname: Hooper
authors.forename: Carole A
authors.initials: CA
authors.lastname: Bewley
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D047630:Depsipeptides