title: GERD in 2010: diagnosis, novel mechanisms of disease and promising agents.
abstract: The results of various studies from 2010 have underlined the importance of the careful diagnostic assessment of GERD. Recent studies have also provided further evidence of the complex pathogenesis of GERD, and promising agents targeting the underlying factors in the pathogenesis of this condition are in the pipeline, especially for treatment-refractory GERD.
authors.affiliation: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Leipziger Straβe 44, Magdeburg, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Kandulski
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D016099:Endoscopy, Gastrointestinal; D004947:Esophagus / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009853:Omeprazole / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D044464:Receptor, PAR-2 / Q000502:physiology
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D044464:Receptor, PAR-2; D009853:Omeprazole