title: Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia.
abstract: We report a case of a child with precursor-B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL-directed therapy and HLH-directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post-transplant and in remission from leukemia and HLH.
authors.affiliation: Department of Pediatrics, Advocate Hope Children's Hospital, Oak Lawn, Illinois 60453, USA.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Kelly
authors.forename: Sharad
authors.initials: S
authors.lastname: Salvi
authors.forename: Kenneth
authors.initials: K
authors.lastname: McClain
authors.forename: Ammar
authors.initials: A
authors.lastname: Hayani
mesh_terms: D002648:Child; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy