title: Concurrent oxidations with tandem biocatalysts in one pot: green, selective and clean oxidations of methylene groups to ketones.
abstract: A novel tandem-biocatalysts system consisting of a monooxygenase-containing microorganism and an alcohol dehydrogenase is developed for the concurrent oxidations of methylene groups to ketones in one pot, providing green, clean and simple access to valuable ketones with high yield, excellent selectivity and efficient cofactor recycling.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Weng Lin
authors.initials: WL
authors.lastname: Tang
authors.forename: Daniel I C
authors.initials: DI
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism; D055162:Biocatalysis; D007659:Ketones / Q000737:chemistry*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D007659:Ketones; D006899:Mixed Function Oxygenases; D000426:Alcohol Dehydrogenase