title: Genetic controls of Th17 cell differentiation and plasticity.
abstract: CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naïve T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2 cells, several novel effector T cell subsets have been recently identified, including Th17 cells. There has been rapid progress in characterizing the development and function of Th17 cells. Here I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases.
authors.affiliation: Department of Immunology and Center for Inflammation and Cancer, M.D. Anderson Cancer Center, Houston, TX, USA. cdong@mdanderson.org
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D019070:Cell Lineage; D016207:Cytokines / Q000235:genetics*; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D016207:Cytokines; D020381:Interleukin-17; D014157:Transcription Factors