title: ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering.
abstract: Porous monolithic inorganic/polymeric hybrid materials have been prepared via ring-opening metathesis copolymerization starting from a highly polar monomer, i.e., cis-5-cyclooctene-trans-1,2-diol and a 7-oxanorborn-2-ene-derived cross-linker in the presence of porogenic solvents and two types of inorganic nanoparticles (i.e., CaCO₃ and calcium hydroxyapatite, respectively) using the third-generation Grubbs initiator RuCl₂(Py)₂(IMesH₂)(CHPh). The physico-chemical properties of the monolithic materials, such as pore size distribution and microhardness were studied with regard to the nanoparticle type and content. Moreover, the reinforced monoliths were tested for the possible use as scaffold materials in tissue engineering, by carrying out cell cultivation experiments with human adipose tissue-derived stromal cells.
authors.affiliation: Leibniz-Institut für Oberflächenmodifizierung e. V. (IOM), Permoserstrasse 15, D-04318 Leipzig, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Weichelt
authors.forename: Solvig
authors.initials: S
authors.lastname: Lenz
authors.forename: Stefanie
authors.initials: S
authors.lastname: Tiede
authors.forename: Ingrid
authors.initials: I
authors.lastname: Reinhardt
authors.forename: Bernhard
authors.initials: B
authors.lastname: Frerich
authors.forename: Michael R
authors.initials: MR
authors.lastname: Buchmeiser