title: Distinctive effects of plant protein sources on renal disease progression and associated cardiac hypertrophy in experimental kidney disease.
abstract: METHODS
  Dietary soy protein reduces renal disease progression in a number of renal diseases, suggesting that plant compared with animal proteins may be renoprotective. The inclusion of other plant protein sources could enhance compliance of intervention diets, but the effects of other plant protein sources are not known.
  
  
  RESULTS
  Weanling Han:SPRD-cy rats with experimental polycystic kidney disease were given hemp-, pea- and soy protein-based diets compared with the standard AIN 93G diet with casein as the protein source. Kidneys from diseased rats given diets which contained soy or hemp protein compared with casein-based diets were less enlarged, had lower fluid content, smaller cyst volumes, less fibrosis, lower chemokine receptor 2 (CCR2) levels and normalized serum creatinine levels. Soy and hemp protein diets also normalized heart size, which was enlarged in diseased compared with normal rats consuming casein. Kidneys from diseased rats given pea protein compared with casein were more enlarged and had higher fluid content and cyst volumes, despite growing better and having lower serum creatinine and renal chemokine receptor 2 levels, and similar levels of renal fibrosis.
  
  
  CONCLUSIONS
  Not all plant proteins are equally protective in experimental kidney disease and associated cardiac hypertrophy.
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada. aukema@umanitoba.ca
authors.forename: Harold M
authors.initials: HM
authors.lastname: Aukema
authors.forename: Joy
authors.initials: J
authors.lastname: Gauthier
authors.forename: Manon
authors.initials: M
authors.lastname: Roy
authors.forename: Yong
authors.initials: Y
authors.lastname: Jia
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.forename: Rotimi E
authors.initials: RE
authors.lastname: Aluko
mesh_terms: D000818:Animals; D001835:Body Weight; D002188:Cannabis / Q000737:chemistry; D006332:Cardiomegaly / Q000209:etiology* / Q000473:pathology; D002364:Caseins / Q000494:pharmacology; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005355:Fibrosis; D007668:Kidney / Q000254:growth & development / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D009929:Organ Size; D018532:Pisum sativum / Q000737:chemistry; D014674:Plant Proteins, Dietary / Q000494:pharmacology*; D051381:Rats; D054390:Receptors, CCR2 / Q000187:drug effects / Q000378:metabolism; D030262:Soybean Proteins / Q000494:pharmacology
chemical_list: D002364:Caseins; C515336:Ccr2 protein, rat; D014674:Plant Proteins, Dietary; D054390:Receptors, CCR2; D030262:Soybean Proteins; D003404:Creatinine