title: Neurologic complications after off-pump coronary artery bypass grafting with and without aortic manipulation: meta-analysis of 11,398 cases from 8 studies.
abstract: OBJECTIVE
  Neurologic complications after coronary artery bypass grafting remain a concern. Off-pump coronary artery bypass grafting is a surgical strategy proposed to decrease this risk. Use of an off-pump anaortic technique, which leaves the ascending aorta untouched, may result in further reductions. This systematic review of all published evidence compares neurologic complications after anaortic off-pump coronary artery bypass grafting versus that with aortic manipulation.
  
  
  METHODS
  PubMed and Embase were searched up to August 2008. Experts were contacted, and reference lists of retrieved articles were hand searched. The search process was not limited to English-language sources. Observational studies comparing standard off-pump coronary artery bypass grafting technique with anaortic technique were eligible for inclusion if they reported neurologic complications (stroke and transient ischemic attack). Meta-analysis was conducted to assess differences between groups with regard to neurologic complications.
  
  
  RESULTS
  Electronic search identified 1428 abstracts, which resulted in retrieval and detailed review of 331 full-text articles. Eight observational studies reported neurologic complications in 5619 anaortic off-pump coronary artery bypass grafting cases and 5779 cases with aortic manipulation. Postsurgical neurologic complications were significantly lower in anaortic off-pump coronary artery bypass grafting cases (odds ratio, 0.46; 95% confidence interval, 0.29-0.72; I(2) = 0.8%; P = .0008).
  
  
  CONCLUSIONS
  Avoidance of aortic manipulation during off-pump coronary artery bypass grafting decreases neurologic complications relative to standard technique in which the ascending aorta is manipulated. In patients at high risk for stroke or transient ischemic attack, we recommend avoidance of aortic manipulation during off-pump coronary artery bypass grafting.
authors.affiliation: Department of Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Leipzig, Germany. martinmisfeld@yahoo.com
authors.forename: Martin
authors.initials: M
authors.lastname: Misfeld
authors.forename: R John L
authors.initials: RJ
authors.lastname: Brereton
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Sweetman
authors.forename: Gordon S
authors.initials: GS
authors.lastname: Doig
mesh_terms: D001011:Aorta / Q000601:surgery*; D047549:Coronary Artery Bypass, Off-Pump / Q000379:methods*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology* / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D020521:Stroke / Q000209:etiology* / Q000517:prevention & control