title: Experience with extrarenal manifestations of hemorrhagic fever with renal syndrome in a tertiary care hospital in South Korea.
abstract: Reports on the clinical entity of hemorrhagic fever with renal syndrome (HFRS) have focused on acute renal failure. Data on the extrarenal manifestations are limited primarily to case reports. In this study, protean extrarenal manifestations involving the major organs occurred in one-third of patients with HFRS during various stages (i.e., febrile phase through diuretic phase). Pancreatobiliary manifestations and major bleeding occurred in 11% and 10% of patients, respectively. Cardiovascular and central nervous system manifestations developed during the febrile or oliguric phase, whereas pancreatobiliary manifestations and major bleeding were detected even in the diuretic phase. Thus, close monitoring of and additional knowledge about various extrarenal manifestations are needed.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Kyung Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Yong Un
authors.initials: YU
authors.lastname: Kang
authors.forename: Seung-Ji
authors.initials: SJ
authors.lastname: Kang
authors.forename: Young-Sun
authors.initials: YS
authors.lastname: Jung
authors.forename: Hee-Chang
authors.initials: HC
authors.lastname: Jang
authors.forename: Sook-In
authors.initials: SI
authors.lastname: Jung
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D001652:Bile Ducts / Q000473:pathology; D002490:Central Nervous System / Q000473:pathology; D002761:Cholangitis / Q000209:etiology; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology; D056910:Republic of Korea