title: PneumococcaL meningitis in french children before and after the introduction of pneumococcal conjugate vaccine.
abstract: In France, despite a high rate of pneumococcal conjugate vaccine coverage, the number of cases of pneumococcal meningitis in children did not decline signiﬁcantly between 2001–2002 (n = 264) and 2007–2008 (n = 244). A decline was observed among children < 2 years old (185 [70.1%] to 134 [54.9%] cases; P = 0.0004), but was counterbalanced by an increase among children ≥ 2 years old (79 [29.9%] to 110 [45.1%] cases). Mean age increased signiﬁcantly, from 2.3 (median 0.8) to 3.8 (median 1.5) years. After pneumococcal conjugate vaccine 7 implementation, a wide diversity of serotypes implicated in pneumococcalmeningitis was observed; serotypes 19A and 7F were the most frequent.
authors.affiliation: GPIP (Groupe de Pathologie Infectieuse Pe ´diatrique) de la SFP (Socie ´te ´ Franc ¸aise de Pe ´diatrie), Paris, France. activ@wanadoo.fr
authors.forename: Corinne
authors.initials: C
authors.lastname: Levy
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Varon
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Aurélie
authors.initials: A
authors.lastname: Lécuyer
authors.forename: Michel
authors.initials: M
authors.lastname: Boucherat
authors.forename: Robert
authors.initials: R
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D015373:Bacterial Typing Techniques; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000302:isolation & purification
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines