title: Strategies towards improving the pharmacokinetic profile of ε-substituted lysinol-derived HIV protease inhibitors.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486, USA. hemaka_rajapakse@merck.com
authors.forename: Hemaka A
authors.initials: HA
authors.lastname: Rajapakse
authors.forename: Abbas M
authors.initials: AM
authors.lastname: Walji
authors.forename: Keith P
authors.initials: KP
authors.lastname: Moore
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Aurpon W
authors.initials: AW
authors.lastname: Mitra
authors.forename: Alison R
authors.initials: AR
authors.lastname: Gregro
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Tinney
authors.forename: Christine
authors.initials: C
authors.lastname: Burlein
authors.forename: Sinoeun
authors.initials: S
authors.lastname: Touch
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Paton
authors.forename: Steven S
authors.initials: SS
authors.lastname: Carroll
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: DiStefano
authors.forename: Ming-Tain
authors.initials: MT
authors.lastname: Lai
authors.forename: Jay A
authors.initials: JA
authors.lastname: Grobler
authors.forename: Rosa I
authors.initials: RI
authors.lastname: Sanchez
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Williams
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Vacca
authors.forename: Philippe G
authors.initials: PG
authors.lastname: Nantermet
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008239:Lysine / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D017320:HIV Protease Inhibitors; D008239:Lysine