title: Obesity-associated genetic variants in young Asian Indians with the metabolic syndrome and myocardial infarction.
abstract: OBJECTIVE
  Associations between obesity-related polymorphisms and the metabolic syndrome in 485 young ( ≤ 45 Years) Asian Indian patients with acute myocardial infarction (AMI), and 300 matched controls were assessed.
  
  
  METHODS
  Genetic variants included the adiponectin 45T→G and 276G→T, LEPR K109R and Q223R, MC4R-associated C→T and FTO A→T polymorphisms.
  
  
  RESULTS
  The metabolic syndrome, as defined by NCEP ATP III and IDF criteria, was diagnosed in 61 and 60% of patients, respectively. No relationship was found between the obesity-associated polymorphisms and the metabolic syndrome, or between AMI patients and controls. The MC4R-associated TT genotype occurred more frequently in patients with lower triglyceride levels (p = 0.024), while the adiponectin 45 TT genotype occurred more commonly in patients with normal fasting glucose levels (p = 0.004). The LEPR Q223R TT genotype was associated with low high-density lipoprotein (HDL) cholesterol levels (p = 0.003).
  
  
  CONCLUSIONS
  The metabolic syndrome occurs commonly in young Asian Indian patients with AMI. No relationship was found between any obesity-associated polymorphism and the metabolic syndrome. Particular genotypes may exert protective or disadvantageous effects on individual components of the metabolic syndrome.
authors.affiliation: Department of Medicine, Coronary Care Unit, RK Khan Hospital, Chemical Pathology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, and Biostatistics Unit, Medical Research Council of South Africa. ranjith@lantic.co.za
authors.forename: N
authors.initials: N
authors.lastname: Ranjith
authors.forename: R J
authors.initials: RJ
authors.lastname: Pegoraro
authors.forename: R
authors.initials: R
authors.lastname: Shanmugam
mesh_terms: D052242:Adiponectin / Q000235:genetics; D050154:Adiposity / Q000208:ethnology; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D009765:Obesity / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; C470072:MC4R protein, human; D011506:Proteins; D044105:Receptor, Melanocortin, Type 4; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human