title: Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology.
abstract: BACKGROUND
  It is necessary to understand the etiologic structure of child and adolescent psychopathology to advance theory and guide future research.
  
  
  OBJECTIVE
  To test alternative models of the higher-order structure of etiologic effects on 11 dimensions of child and adolescent psychopathology using confirmatory factor analyses of genetic and environmental covariances.
  
  
  METHODS
  Representative sample of twins.
  
  
  METHODS
  Home interviews.
  
  
  METHODS
  A total of 1571 pairs of 9- to 17-year-old twins.
  
  
  METHODS
  Structured assessments of psychopathology using adult caregivers and youth as informants.
  
  
  RESULTS
  The best-fitting genetic model revealed that most genetic factors nonspecifically influence risk for either all 11 symptom dimensions or for dimensions of psychopathology within 1 of 2 broad domains. With some notable exceptions, dimension-specific genetic influences accounted for modest amounts of variance.
  
  
  CONCLUSIONS
  To inform theory and guide molecular genetic studies, an etiologic model is offered in which 3 patterns of pleiotropy are hypothesized to be the principal modes of genetic risk transmission for common forms of child and adolescent psychopathology. Some common environmental influences were found, but consistent with a "generalist genes, specialist environments" model, there was little sharing of environmental influences. This implies that prevalent dimensions of child and adolescent psychopathology mostly share their genetic liabilities but are differentiated by nonshared experiences.
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, Illinois 60637, USA. blahey@uchicago.edu
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Lahey
authors.forename: Carol A
authors.initials: CA
authors.lastname: Van Hulle
authors.forename: Amber L
authors.initials: AL
authors.lastname: Singh
authors.forename: Irwin D
authors.initials: ID
authors.lastname: Waldman
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Rathouz
mesh_terms: D000293:Adolescent; D000379:Agoraphobia / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D001008:Anxiety Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D002648:Child; D019955:Conduct Disorder / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D005163:Factor Analysis, Statistical; D005260:Female; D058685:Genetic Pleiotropy / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015994:Incidence; D007389:Internal-External Control; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D008960:Models, Psychological; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D010641:Phenotype; D010698:Phobic Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D012307:Risk Factors; D012931:Social Environment