title: Deltamethrin Increases Candida albicans infection susceptibility in mice.
abstract: Deltamethrin, an alpha-cyano type II synthetic pyrethroid insecticide, is used to control a wide range of insects on a variety of crops and vectors of diseases. Deltamethrin has been previously reported for its immunotoxic effects and therefore its exposure may affect the host resistance to infection and tumour challenge. Effect of exposure of deltamethrin on host resistance to Candida albicans infection was examined in Swiss albino mice. The objective of this study was to investigate the modulatory action of deltamethrin in C. albicans infected mice. The dose of deltamethrin was initially tested and selected from our previous study (18 mg/kg). Percentage of infection in deltamethrin treated animals increased faster when compared to that of the controls. Deltamethrin exposure along with C. albicans infection caused alteration of humoral immune response. The number of colony forming unit in liver and spleen were also found to be significantly increased in the treated group. The results from our present study suggest that deltamethrin exhibits an immunosuppressive effect and has a negative impact on host resistance to C. albicans infection.
authors.affiliation: Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India.
authors.forename: H
authors.initials: H
authors.lastname: Rehman
authors.forename: A
authors.initials: A
authors.lastname: Mohan
authors.forename: H
authors.initials: H
authors.lastname: Tabassum
authors.forename: F
authors.initials: F
authors.lastname: Ahmad
authors.forename: S
authors.initials: S
authors.lastname: Rahman
authors.forename: S
authors.initials: S
authors.lastname: Parvez
authors.forename: S
authors.initials: S
authors.lastname: Raisuddin
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000187:drug effects* / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology*; D015169:Colony Count, Microbial; D005260:Female; D006168:Guinea Pigs; D007108:Immune Tolerance / Q000187:drug effects; D056724:Immunity, Humoral / Q000276:immunology; D007306:Insecticides / Q000276:immunology / Q000633:toxicity*; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D009570:Nitriles / Q000276:immunology / Q000633:toxicity*; D011722:Pyrethrins / Q000276:immunology / Q000633:toxicity*; D013154:Spleen / Q000382:microbiology
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin