title: Endoplasmic reticulum stress and lipid dysregulation.
abstract: Cellular cholesterol homeostasis is a fundamental and highly regulated process. Transcription factors known as sterol regulatory element binding proteins (SREBPs) coordinate the expression of many genes involved in the biosynthesis and uptake of cholesterol. Dysregulation of SREBP activation and cellular lipid accumulation has been associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR). This review will provide an overview of ER stress and the UPR as well as cholesterol homeostasis and SREBP regulation, with an emphasis on their interaction and biological relevance.
authors.affiliation: Department of Medicine and Division of Nephrology, St Joseph's Healthcare Hamilton and McMaster University, Hamilton, Ontario, Canada.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Colgan
authors.forename: Ali A
authors.initials: AA
authors.lastname: Hashimi
authors.forename: Richard C
authors.initials: RC
authors.lastname: Austin
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D025461:Feedback, Physiological; D006801:Humans; D050356:Lipid Metabolism; D052439:Lipid Metabolism Disorders / Q000209:etiology / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation; D056811:Unfolded Protein Response / Q000235:genetics / Q000502:physiology*
chemical_list: C497387:SREBF1 protein, human; C497390:SREBF2 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D051782:Sterol Regulatory Element Binding Protein 2; D002784:Cholesterol