title: The effect of insulin resistance and obesity on low-density lipoprotein particle size in children.
abstract: OBJECTIVE
  In adults, it was shown that obesity and insulin resistance affect low-density lipoprotein (LDL) particle size and small dense (sd) LDL is associated with cardiovascular diseases. In this study, we investigated the effect of obesity and insulin resistance on LDL particle size.
  
  
  METHODS
  Twenty-six obese children (13 girls, 13 boys) with a median age of 10.5 years and 27 healthy control subjects (17 girls, 10 boys) with a median age of 11.5 were enrolled in the study.
  
  
  RESULTS
  The number of patients with insulin resistance in the obese group was 15 out of 26. In the control group, there was no subject with insulin resistance. Serum triglyceride and very LDL (VLDL) levels were higher and serum high-density lipoprotein levels (HDL) were lower in the obese patients than in the controls. There was no statistical difference in the LDL particle size between the two groups (medians: 26.6 vs. 26.7 nm (p=0.575)). The size of LDL particle was not correlated with body mass index (BMI) standard deviation score (SDS), homeostasis model assessment of insulin resistance (HOMA-IR), or serum lipids.
  
  
  CONCLUSIONS
  Measurement of LDL particle size as a routine procedure is not necessary in childhood obesity.
authors.affiliation: Gulhane Military Medical Academy, Department of Pediatrics, Division of Pediatric Endocrinology, Ankara, Turkey.
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Taşcılar
authors.forename: Tolga
authors.initials: T
authors.lastname: Özgen
authors.forename: Murat
authors.initials: M
authors.lastname: Cihan
authors.forename: Ayhan
authors.initials: A
authors.lastname: Abacı
authors.forename: Ediz
authors.initials: E
authors.lastname: Yeşilkaya
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Eker
authors.forename: Muhiddin
authors.initials: M
authors.lastname: Serdar
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood* / Q000503:physiopathology*; D010316:Particle Size; D014280:Triglycerides / Q000097:blood
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol