title: The expression of interleukin (IL)-17 and IL-17 receptor and MMP-9 in human pituitary adenomas.
abstract: The IL-17 plays a crucial role in the invasion of tumors. However, the effects of IL-17 on the invasion of human pituitary adenomas are still unknown. The current study is designed to investigate the possible involvement of IL-17 in the invasion of adenomas. By collecting invasive and non-invasive pituitary adenomas, the mRNA and protein levels of IL-17, IL-17R and MMP-9 are investigated. The results obtained from IHC showed that the strong positive rate and the total positive rate of IL-17, IL-17R and MMP-9 expression cells in the non-invasive group were 17.1 and 51.43%, 14.3 and 54.3%, 17.1 and 57.1%, respectively. In contrast, the strong positive rate and the total positive rate of the invasive group were significantly higher than that of the non-invasive group, which were 37.5 and 82.5%, 52.5 and 87.5%, 67.5 and 92.5%, respectively. Meanwhile, the serum IL-17 level in the invasive pituitary adenomas patients was significantly higher than in the non-invasive groups (P < 0.05). Furthermore, the mRNA levels of IL-17, IL-17R and MMP-9 were also higher in the invasive group than in the non-invasive group with statistical differences (P < 0.05), and where the expression levels of IL-17 and IL-17R had positive correlation with that of MMP-9 in the invasive group. These results suggested that IL-17 may promote the invasion of pituitary adenomas.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, 510080, Guangzhou, People's Republic of China.
authors.forename: Lubin
authors.initials: L
authors.lastname: Qiu
authors.forename: Dongsheng
authors.initials: D
authors.lastname: He
authors.forename: Xiang
authors.initials: X
authors.lastname: Fan
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Chuangxin
authors.initials: C
authors.lastname: Liao
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhu
authors.forename: Haijun
authors.initials: H
authors.lastname: Wang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17; D020780:Matrix Metalloproteinase 9