title: Novel trends in celiac disease.
abstract: Celiac disease (CD) is one of the most common food intolerances in developed world. It affects genetically susceptible individuals and has severe consequences if it remains undiagnosed. A disease known for more than a century, it is still the focus for experts from various fields of research and development. Geneticists, pathologists, immunologists, food engineers and dieticians share their knowledge and expertise to improve the conditions of CD patients. With new insights in the pathomechanism of gluten processing and antigen presentation in CD, it was possible to improve the diagnostic antigen mimicking the primary epitope in CD. These celiac neo-epitopes are comprised of a complex of gliadin peptides crosslinked with transglutaminase (tTg). They are an early diagnostic marker for CD which occurs up to 6 months earlier than classical markers known to miss a certain amount of CD patients.
authors.affiliation: AESKU.KIPP Institute, Wendelsheim, Germany. matthias@aesku-kipp.com
authors.forename: Torsten
authors.initials: T
authors.lastname: Matthias
authors.forename: Sandra
authors.initials: S
authors.lastname: Neidhöfer
authors.forename: Sascha
authors.initials: S
authors.lastname: Pfeiffer
authors.forename: Kai
authors.initials: K
authors.lastname: Prager
authors.forename: Sandra
authors.initials: S
authors.lastname: Reuter
authors.forename: M Eric
authors.initials: ME
authors.lastname: Gershwin
mesh_terms: D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D003657:Decision Making; D006801:Humans