title: MicroRNAs in Parkinson's disease.
abstract: MicroRNAs are small non-protein coding RNAs that regulate gene expression through post-transcriptional repression. Recent studies demonstrated the importance of microRNAs in the nervous system development, function and disease. Parkinson's disease is the second most prevalent neurodegenerative disease with only symptomatic treatment available. Recent success in using small RNAs as therapeutic targets hold a substantial promise for the Parkinson's disease field. Here we review recent work linking the microRNA pathway to Parkinson's disease.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Maged M
authors.initials: MM
authors.lastname: Harraz
authors.forename: Ted M
authors.initials: TM
authors.lastname: Dawson
authors.forename: Valina L
authors.initials: VL
authors.lastname: Dawson
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D009434:Neural Pathways / Q000378:metabolism / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D034622:RNA Interference / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs; D009419:Nerve Tissue Proteins