title: How does a simple enquiry compare to a detailed family history questionnaire to identify coronary heart disease or diabetic familial risk?
abstract: OBJECTIVE
  To examine whether a simple enquiry can provide similar family history information compared with a detailed questionnaire for coronary heart disease or diabetes.
  
  
  METHODS
  Data from two randomized controlled trials were extracted that assess the clinical value of using family history information for either coronary heart disease (ISRCTNI17943542) or diabetes risk assessment (NTR1938) in a community-based population. Outcome measures were percentage agreement, sensitivity, and specificity of self-reported family history for coronary heart disease and diabetes by means of a simple enquiry, when compared with a detailed questionnaire.
  
  
  RESULTS
  Agreement between both family history tools was 76.8% for first-degree relatives with coronary heart disease, and 89.2% and 87.6% for first- and second-degree relatives with diabetes, respectively. The sensitivity was 44.2% for first-degree relatives with coronary heart disease, 81.9% for first-degree relatives with diabetes, and 35.4% for second-degree relatives with diabetes. Specificity was 89.3%, 97.0%, and 94.5%, respectively.
  
  
  CONCLUSIONS
  Compared with a detailed questionnaire, the simple enquiry correctly identified the majority of individuals classified as having no significant family history but missed a significant proportion of individuals with positive family history. Incorrect classification of family history, in particular the high false-negative rate, has implications on the utility of a simple enquiry in identifying familial risk in clinical practice.
authors.affiliation: Department of Public and Occupational Health , EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. m.pijl@vumc.nl
authors.forename: Miranda
authors.initials: M
authors.lastname: Wijdenes-Pijl
authors.forename: Lidewij
authors.initials: L
authors.lastname: Henneman
authors.forename: Laura
authors.initials: L
authors.lastname: Cross-Bardell
authors.forename: Danielle R M
authors.initials: DR
authors.lastname: Timmermans
authors.forename: Nadeem
authors.initials: N
authors.lastname: Qureshi
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D011795:Surveys and Questionnaires / Q000592:standards*