title: [Granulomatous skin disease in an immunocompromised child].
abstract: BACKGROUND
  The development of systemic and/or cutaneous granulomas associated with immunodeficiency is well established, particularly with common variable immunodeficiency (CVID). We report the case of an immunocompromised child presenting with cutaneous granulomas, predominantly on the face.
  
  
  METHODS
  A boy aged 6 years and 9 months presenting complex and incompletely defined immunodeficiency presented with gradually worsening cutaneous lesions of granulomatous aspect on his face and right foot. Extensive laboratory tests showed no infectious or neoplastic processes. Biopsies of the lesions confirmed the presence of granulomas. Systemic corticosteroids produced no satisfying improvement and were changed to anti-TNFα. The lesions had completely disappeared after 6 months. Treatment was continued for 6 months, with no relapse 6 months after discontinuation.
  
  
  CONCLUSIONS
  The originality of our case lies in the presentation of cutaneous granulomas, appearing in the context of an undefined immunodeficiency other than CVID, as well as in the therapeutic aspect, with the successful use of biotherapies in such a clinical setting.
authors.affiliation: Département interhospitalier de dermatologie (CHU Saint-Pierre, CHU Brugmann, hôpital universitaire des enfants Reine-Fabiola), 15 avenue J.-J. Crocq, Brussels, Belgium. jboudart@ulb.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Boudart
authors.forename: W
authors.initials: W
authors.lastname: Fink
authors.forename: A
authors.initials: A
authors.lastname: Theunis
authors.forename: C
authors.initials: C
authors.lastname: Dangoisse
authors.forename: A
authors.initials: A
authors.lastname: Ferster
authors.forename: J
authors.initials: J
authors.lastname: André
mesh_terms: D002648:Child; D006099:Granuloma / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008297:Male; D012871:Skin Diseases / Q000276:immunology*