title: Biomimetic total syntheses of flinderoles B and C.
abstract: A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- and regioselective [3 + 2] reaction cascade was developed and then further applied in the first total synthesis of flinderoles B and C, which proceeded in 17.2% yield over the longest linear sequence of 11 steps.
authors.affiliation: Organic Chemistry Division, National Chemical Laboratory, Pune 411008, Maharashtra, India. dh.dethe@ncl.res.in
authors.forename: Dattatraya H
authors.initials: DH
authors.lastname: Dethe
authors.forename: Rohan D
authors.initials: RD
authors.lastname: Erande
authors.forename: Alok
authors.initials: A
authors.lastname: Ranjan
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis; D032701:Biomimetics / Q000191:economics / Q000379:methods*; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D008288:Malaria / Q000188:drug therapy; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D026121:Indole Alkaloids; C538847:flinderole B; C538848:flinderole C