title: Advanced hypopharyngeal cancer with amyotrophic lateral sclerosis.
abstract: We present a case of advanced hypopharyngeal cancer occurring in a patient with amyotrophic lateral sclerosis (ALS). A 58-year-old man diagnosed with ALS 2 years previously noticed a mass in his neck and dysphagia. We diagnosed him as having hypopharyngeal squamous cell carcinoma with the left cervical lymph node metastases (T3N2bM0) and treated with concurrent chemoradiotherapy. During and after the treatment, his neurological symptoms showed no worse signs. The patient has been cancer-free for 13 months after concurrent chemoradiotherapy. The influence of ALS on the patients' quality of life (QOL) and/or prognosis had to be taken into consideration when determining an appropriate treatment for the hypopharyngeal cancer. To the best of our knowledge, this may be the first case with ALS who was treated for hypopharyngeal cancer.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, Japan.
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Kogashiwa
authors.forename: Naoki
authors.initials: N
authors.lastname: Oishi
authors.forename: Kohichi
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kohno
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000628:therapy*; D059248:Chemoradiotherapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000150:complications / Q000628:therapy*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged