title: The "bridge" game: role of the fourth player in chiral recognition.
abstract: A new team player: The "three-point interaction" model, which is usually employed to rationalize chiral recognition, does not account for the amazing enantioselectivity measured for the receptors of many proteic acceptors. Gas-phase experiments have indicated that at least a fourth "player" must be considered: the rigidity that a receptor opposes to distortions of its cavity resulting from noncovalent interactions with a chiral molecule (see picture).
authors.affiliation: Dipartimento degli Studi di Chimica e Tecnologie del Farmaco, Università di Roma La Sapienza, 00185 Roma, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Fraschetti
authors.forename: Marco
authors.initials: M
authors.lastname: Pierini
authors.forename: Claudio
authors.initials: C
authors.lastname: Villani
authors.forename: Francesco
authors.initials: F
authors.lastname: Gasparrini
authors.forename: Stefano Levi
authors.initials: SL
authors.lastname: Mortera
authors.forename: Antonello
authors.initials: A
authors.lastname: Filippi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Speranza
mesh_terms: D002082:Butylamines / Q000737:chemistry; D005740:Gases / Q000737:chemistry; D013058:Mass Spectrometry; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D002082:Butylamines; D005740:Gases