title: Catalytic enantioselective synthesis of A-86929, a dopamine D1 agonist.
abstract: A-86929, a dopamine D1 agonist was synthesized with 95% ee in five steps with overall yield of 56% via catalytic enantioselective one-pot aziridination followed by Friedel-Crafts cyclization and a mild Pictet-Spengler cyclization protocol.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. shajra@chem.iitkgp.ernet.in
authors.forename: Saumen
authors.initials: S
authors.lastname: Hajra
authors.forename: Sukanta
authors.initials: S
authors.lastname: Bar
mesh_terms: D002384:Catalysis; D003500:Cyclization; D018491:Dopamine Agonists / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D018491:Dopamine Agonists; D015363:Quinolones; D013876:Thiophenes; C095427:A 86929