title: [The relationship between the CT signs and p53 abnormal expression in peripheral lung cancer].
abstract: BACKGROUND
  To evaluate the relationship between the CT signs and p53 protein abnormal expression in peripheral lung cancer.
  
  
  METHODS
  Fifty-two patients with pulmonary masses underwent CT scanning before operation. Immunohistochemistry was used to detect p53 protein expression in pulmonary specimens obtained by operation.
  
  
  RESULTS
  There were significant differences among p53 protein expression and differentiation of lung cancer cell, size of the cancer, tumor appearance, pleura excavation and lymphatic metastasis.
  
  
  CONCLUSIONS
  p53 gene mutation indicates the biological behavior of lung cancer and might influence the morphological feature of lung cancer, which remarkably relates to CT signs of lung cancer.
authors.affiliation: Image Department, The Third Hospital, Harbin Medical University, Harbin, Heilongjiang 150040, P.R.China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Liu
authors.forename: Weixing
authors.initials: W
authors.lastname: Zhang
authors.forename: Guifen
authors.initials: G
authors.lastname: Gao