title: Cobalt bis(dicarbollide) derivatives: solubilization and self-assembly suppression.
abstract: Cobalt bis(dicarbollide) derivatives are promising therapeutic agents however their utilization is complicated due to their low solubility and self-assembling in water. Earlier we have shown that their solubility can be increased by using of suitable biocompatible excipients--carriers of pharmaceutically active compounds. Expected mechanism of solubilization was disassembling of self-assemblies and complexation of unimers. Newly our results of time-dependent light scattering study correct this presumption. Poor solubility of all derivatives can be easily improved by using various excipients, however only heptakis(2,6-di-O-methyl)-β-cyclodextrin displays ability to disassemble self-assemblies of all derivatives and suppress their self-assembling. Surprisingly, the other excipients participate on formation of mixed assemblies of derivative/excipient complex or cover assemblies to make them more soluble without decreasing their size.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemical Engineering, Institute of Chemical Technology, Technická 5, 166 28 Prague 6, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Rak
authors.forename: Milan
authors.initials: M
authors.lastname: Jakubek
authors.forename: Robert
authors.initials: R
authors.lastname: Kaplánek
authors.forename: Pavel
authors.initials: P
authors.lastname: Matějíček
authors.forename: Vladimír
authors.initials: V
authors.lastname: Král
mesh_terms: D001682:Biological Availability; D003035:Cobalt / Q000737:chemistry*; D057446:Hydrodynamics; D008027:Light; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D012542:Scattering, Radiation; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D014867:Water; D003035:Cobalt