title: Extended criteria donors in liver transplant candidates with hepatorenal syndrome.
abstract: Hepatorenal syndrome (HRS) is a complication of cirrhosis with a poor prognosis without transplantation. The aim of this study is to analyze the influence of extended criteria donors (ECD) on the postoperative outcome of recipients with HRS. The last 498 patients were divided according to pre-transplant type 1 or 2 HRS. Sixty-six (13.25%) recipients fulfilled HRS criteria. Three-month graft survival was 84% with at-listing recipient serum creatinine ranging from 0-0.8 mg/dL; 80% with s-creatinine = 0.9-1.5 mg/dL; 79% with s-creatinine = 1.6-2.5 mg/dL; and 58% with s-creatinine >2.6 mg/dL (log-rank = 18.039; p = 0.001). Recipients with HRS presented higher levels of pre-transplant creatinine and lower levels of sodium, more episodes of hemodialysis and ascitis, and higher model of end-stage liver disease-scores. Three-month graft survival in recipients with HRS relative to ECD-variables showed differences in univariate analysis according to graft steatosis (85% in absent steatosis = 0-10%; 78% in mild steatosis = 10-30%; 76% in moderate steatosis = 30-60%; and 49% when severe steatosis >60%; log-rank = 5.146; p = 0.023). Cox-proportional-hazard-model revealed that graft macrosteatosis per-30%-increments (p = 0.000; HR = 1.303 [1.24-1.33] per-30%-increment) and donors >65 yr (p = 0.089; HR = 1.622 [1.17-1.94]) were independent predictors of graft loss in recipients with HRS. In conclusion, the use of ECD in recipients with cirrhosis and HRS is a good option. However, grafts from moderate-to-severe steatosis and those from aged donors must be carefully allocated in candidates with HRS.
authors.affiliation: Unit of Liver Transplantation and Hepatobiliary Surgery, University Hospital Reina Sofía, Córdoba, Spain. javibriceno@hotmail.com
authors.forename: Javier
authors.initials: J
authors.lastname: Briceño
authors.forename: Ruben
authors.initials: R
authors.lastname: Ciria
authors.forename: Manuel
authors.initials: M
authors.lastname: de la Mata
authors.forename: José Luis
authors.initials: JL
authors.lastname: Montero
authors.forename: Sebastián
authors.initials: S
authors.lastname: Rufián
authors.forename: Pedro
authors.initials: P
authors.lastname: López-Cillero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006085:Graft Survival; D006530:Hepatorenal Syndrome / Q000601:surgery*; D006801:Humans; D007677:Kidney Function Tests; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D014019:Tissue Donors; D055815:Young Adult