title: [Recurrent herpetic corneal erosion: diagnosis and treatment].
abstract: Recurrent corneal erosion (CE) is a common anterior eye disease, which usually occurs after injury, substantially limits a patient's ability to work, and is intractable. The authors single out an individual form of CE herpetic CE (HCE) on the basis of immunofluorescence assay of a conjunctival scrape, which shows the high concentration of herpes simplex virus antigen in 53% of CE cases. Confocal microscopy revealed epithelocyte polymorphism and basement membrane defects. The treatment of patients with HCE involved 2 steps: 1) relief of acute signs of the disease via drug therapy, rapid local autocyte cinotherapy (RLACCT), or phototherapeutic keratectomy (PTK) and 2) prevention of recurrences. For this the authors developed a method based on the systemic use of a new composition of the intradermal herpes vaccine Vitaherpavac in combination with the subcutaneous interferon inducer Poludan. RLACCT was found to be the most effective medical treatment for CE and PTK was the most effective surgical one. Vaccination with the concurrent subcutaneous injection of Poludan is an effective method in preventing recurrent HCE. During a follow-up of 2 years or more, 81% of the patients achieved clinical resolution; there was a decrease in recurrence rates and severity in 15.1% and no effect in 3.8%.
authors.forename: E A
authors.initials: EA
authors.lastname: Kasparova
authors.forename: A A
authors.initials: AA
authors.lastname: Kasparov
authors.forename: N R
authors.initials: NR
authors.lastname: Marchenko
authors.forename: A
authors.initials: A
authors.lastname: Pur-Akbarian Niiaz
authors.forename: M A
authors.initials: MA
authors.lastname: Makarova
authors.forename: N V
authors.initials: NV
authors.lastname: Borodina
authors.forename: E V
authors.initials: EV
authors.lastname: Smirennaia
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D048988:Corneal Surgery, Laser / Q000379:methods; D003320:Corneal Ulcer / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016849:Keratitis, Herpetic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D011131:Polyribonucleotides / Q000627:therapeutic use; D012008:Recurrence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D011131:Polyribonucleotides; C044366:poludan