title: Traumatic stress, dissociation, and limbic irritability in patients with unipolar depression being treated with SSRIs.
abstract: Recent evidence suggests that stressful experiences may be related to deficits in inhibitory functions and temporo-limbic epileptic-like activity. The latter may produce psychosensory seizure-like symptoms that may also appear in nonepileptic conditions. This study assesses whether the increased presence of the seizure-like symptoms in 113 unipolar depressive patients treated with SSRIs is associated with significantly more severe symptoms of depression, traumatic stress, and dissociation in comparison with 86 healthy controls. Results indicate that seizure-like symptoms in depressive patients have significant association with depression, symptoms of dissociation, and traumatic stress. This association suggests that processess generating seizure-like symptoms may be related to symptoms of depression, traumatic stress, and dissociation.
authors.affiliation: Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. petrbob@netscape.net
authors.forename: Petr
authors.initials: P
authors.lastname: Bob
authors.forename: Marek
authors.initials: M
authors.lastname: Susta
authors.forename: Alica
authors.initials: A
authors.lastname: Gregusova
authors.forename: Denisa
authors.initials: D
authors.lastname: Jasova
authors.forename: Jiri
authors.initials: J
authors.lastname: Raboch
authors.forename: Aaron
authors.initials: A
authors.lastname: Mishara
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology*; D004213:Dissociative Disorders / Q000523:psychology*; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D057566:Self Report; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013315:Stress, Psychological / Q000523:psychology*; D011795:Surveys and Questionnaires
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors