title: Acute parotitis induced by trimethoprim/sulfamethoxazole.
abstract: Adverse drug reactions to the sulfonamide antibiotics are uncommon. When they do occur, they usually manifest as a rash or urticaria. Our review of the recent literature found that while sialadenitis is listed as a possible side effect of sulfonamide use, no actual case has ever been reported until now. We describe a case of acute bilateral parotitis that arose as a side effect of sulfonamide antibiotic treatment. We also examine the relevance of such pathology to the proposed mechanisms of sialadenitis, and we briefly discuss sulfonamide-induced pancreatitis. Lastly, we review the controversy over the possibility that some adverse drug reactions may be caused by cross-reactivity among different classes of sulfonamides.
authors.affiliation: Department of Otolaryngology and Facial Plastic Surgery, Kennedy Memorial Hospitals-University Medical Center, 3101 Burrough's Mill Cir., Cherry Hill, NJ 08002, USA. jspatel09@gmail.com
authors.forename: Jayna S
authors.initials: JS
authors.lastname: Patel
authors.forename: Edward D
authors.initials: ED
authors.lastname: Scheiner
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008775:Methylprednisolone / Q000627:therapeutic use; D010309:Parotitis / Q000139:chemically induced* / Q000188:drug therapy; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D008775:Methylprednisolone