title: Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.
abstract: An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.
authors.affiliation: Molecular Targets Laboratory, Molecular Discovery Program, National Cancer Institute, Frederick, Maryland 21702, United States.
authors.forename: Krishna P
authors.initials: KP
authors.lastname: Devkota
authors.forename: Ranjala
authors.initials: R
authors.lastname: Ratnayake
authors.forename: Nancy H
authors.initials: NH
authors.lastname: Colburn
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Wilson
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Henrich
authors.forename: James B
authors.initials: JB
authors.lastname: McMahon
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D028201:Pinaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D013636:Tanzania; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors*
chemical_list: C558232:11,10-oxymethylenecyclopent-14-isopropyl-8,11,13-podocarpatriene; C558233:11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-al; C558234:11-hydroxy-14-isopropyl-8,11,13-podocarpatrien-19-oic acid; D004224:Diterpenes; D018808:Transcription Factor AP-1