title: Age-specific plasma biochemistry reference ranges in <1 year old dogs in Japan.
abstract: The purpose of this study was to investigate and propose possible reference intervals of plasma biochemical analytes in young dogs (<12 months old) in Japan, using 896 canine plasma samples, collected from an array of veterinary clinics throughout the greater Tokyo metropolis area in Japan. The following biochemical parameters were assessed: albumin (ALB), alanine aminotransferase (ALT), alkaline phosphatase (ALP), amylase, aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine (CRE), glucose, lipase, total cholesterol (T-Cho), and total protein (TP) were evaluated. Multivariate linear regression analysis indicated that partitioning according to age or gender may be necessary for some plasma analytes. Age appeared to significantly affect ALB, ALT, ALP, BUN, Glucose, Lipase, and Total Protein (P= <0.001, <0.001, <0.001, 0.013, <0.001, 0.025, and <0.001, respectively). On the other hand, gender significantly influenced ALP, Amylase, Lipase, and T-Cho levels (P=0.017, <0.001, <0.001, and <0.001, respectively) whereas it may be borderline significant with ALT (P=0.072).
authors.affiliation: School of Veterinary Nursing & Technology, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Sako
authors.forename: Akihiro
authors.initials: A
authors.lastname: Mori
authors.forename: Peter
authors.initials: P
authors.lastname: Lee
authors.forename: Ayano
authors.initials: A
authors.lastname: Igarashi
authors.forename: Hitomi
authors.initials: H
authors.lastname: Oda
authors.forename: Kaori
authors.initials: K
authors.lastname: Saeki
authors.forename: Yohei
authors.initials: Y
authors.lastname: Miki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kurishima
authors.forename: Kana
authors.initials: K
authors.lastname: Mimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nozawa
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Itabashi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kiyosawa
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ishioka
authors.forename: Toshiro
authors.initials: T
authors.lastname: Arai
mesh_terms: D000367:Age Factors; D000818:Animals; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000662:veterinary*; D004285:Dogs / Q000097:blood*; D005260:Female; D008297:Male; D012016:Reference Values; D012044:Regression Analysis; D012737:Sex Factors; D014041:Tokyo