title: Microparticles, malignancy and thrombosis.
abstract: Microparticles (MPs) are considered to be important biological effectors of several different physiological and pathological processes. There is increasing evidence of their role in haemostasis and thrombosis, and also of their importance in cancer cell survival, invasiveness and metastasis. The level of circulating MPs has been assessed in many different disease states, and there are reports that patients with malignancy and patients with thrombosis have increased levels of circulating MPs and MP-dependent thrombogenic potential. Research into the function and effect of MPs is currently hampered by a lack of standardization in the methods used to identify and quantify them. As these methods improve it is likely that MP assays will be of use both diagnostically and therapeutically in the future.
authors.affiliation: College of Medicine and Veterinary Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK. zahrasharon@doctors.org.uk
authors.forename: Sharon
authors.initials: S
authors.lastname: Zahra
authors.forename: Julia A M
authors.initials: JA
authors.lastname: Anderson
authors.forename: David
authors.initials: D
authors.lastname: Stirling
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Ludlam
mesh_terms: D055252:Cell-Derived Microparticles / Q000276:immunology / Q000502:physiology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000503:physiopathology*; D013927:Thrombosis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*