title: Ethyl pyruvate, an anti-inflammatory agent, inhibits tumor angiogenesis through inhibition of the NF-κB signaling pathway.
abstract: Ethyl pyruvate (EP), simple derivative of pyruvate, has been shown to have anti-inflammatory properties. Here, we demonstrate EP's strong anti-angiogenic activity. EP inhibited in vivo angiogenesis in the mouse Matrigel-plug assay and tumor growth in the mouse Lewis lung carcinoma model. EP also interfered with the angiogenic cascade, including growth, invasion, migration, and tube formation. Activation of NF-κB by vascular endothelial cell growth factor was reduced by EP. Taken together, we suggest that EP may have potential as a new multi-functional drug candidate for anti-angiogenesis and cancer therapy.
authors.affiliation: Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Shi-Young
authors.initials: SY
authors.lastname: Park
authors.forename: Eui-Yeun
authors.initials: EY
authors.lastname: Yi
authors.forename: Myunghwan
authors.initials: M
authors.lastname: Jung
authors.forename: You Mie
authors.initials: YM
authors.lastname: Lee
authors.forename: Yung-Jin
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement; D003094:Collagen / Q000737:chemistry; D004338:Drug Combinations; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D007797:Laminin / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D011509:Proteoglycans / Q000737:chemistry; D011773:Pyruvates / Q000494:pharmacology*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014945:Wound Healing
chemical_list: D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D007797:Laminin; D016328:NF-kappa B; D011509:Proteoglycans; D011773:Pyruvates; D042461:Vascular Endothelial Growth Factor A; C046522:ethyl pyruvate; C059485:matrigel; D003094:Collagen