title: The REAL database reveals no significant risk of serious infection during treatment with a methotrexate dose of more than 8 mg/week in patients with rheumatoid arthritis.
authors.affiliation: Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Bunkyo-ku, Yushima, Tokyo, 113-8519, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Sakai
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Komano
authors.forename: Michi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nanki
authors.forename: Ryuji
authors.initials: R
authors.lastname: Koike
authors.forename: Atsuo
authors.initials: A
authors.lastname: Nakajima
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Atsumi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Yasuda
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Saito
authors.forename: Shigeto
authors.initials: S
authors.lastname: Tohma
authors.forename: Takao
authors.initials: T
authors.lastname: Fujii
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ihata
authors.forename: Naoto
authors.initials: N
authors.lastname: Tamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Takahiko
authors.initials: T
authors.lastname: Sugihara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ito
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyasaka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Harigai
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001424:Bacterial Infections / Q000453:epidemiology*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009894:Opportunistic Infections / Q000453:epidemiology*; D018570:Risk Assessment
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate