title: [The efficacy of bronchial artery infusion chemotherapy combined with immunotherapy for lung cancer with malignant hydrothorax].
abstract: BACKGROUND
  To explore the therapeutic effect of bronchial artery infusion chemotherapy combined with immunotherapy for lung cancer with malignant hydrothorax.
  
  
  METHODS
  Seventy-five lung cancer patients with malignant hydrothorax were randomly divided into the two groups: 38 patients were given intrathoracic chemotherapy and bronchial artery infusion chemotherapy combined with immunotherapy as observing group; 37cases only received intrathoracic chemotherapy as control group. Chi-square assay was performed to analyze the efficacy (responses for lung cancer and hydrothorax control) after the first course of treatment and the 1-, 2-year survival rates in the two groups.
  
  
  RESULTS
  After the first course of treatment, the total responses for lung cancer were 31.58% (12/38) and 5.41% (2/37) in the observing group and control group (Chi-square=8.46, P < 0.01) respectively ; and responses for hydrothorax control were 86.84% and 64.86% respectively (Chi-square= 4.96, P <0.05). The 1- and 2-year survival rates in the observing group were 65.79% (25/38) and 26.32% (10/38) respectively, which were significantly higher than those of the control group (40.54% and 5.41%) respectively (Chi-square=4.80, P <0.05; Chi-square=6.10, P <0.05).
  
  
  CONCLUSIONS
  The intrathoracic chemotherapy combined with bronchial artery infusion chemotherapy and immunotherapy is quite effective in the treatment of lung cancer with malignant hydrothorax.
authors.affiliation: Image Center, The First Affiliated Hospital, Kunming Medical College, Kunming, Yunnan 650032, P.R.China.
authors.forename: Liyu
authors.initials: L
authors.lastname: Xie
authors.forename: Jue
authors.initials: J
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Ruilin
authors.initials: R
authors.lastname: Pang
authors.forename: Shutian
authors.initials: S
authors.lastname: Xiang
authors.forename: Xuexian
authors.initials: X
authors.lastname: Dong
authors.forename: Jihong
authors.initials: J
authors.lastname: Hu
authors.forename: Hongfen
authors.initials: H
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Duan