title: [Biochemical parameters and prediction of the development of glaucoma in patients with progressive myopia].
abstract: Examinations were made in 3 groups of patients aged 15 to 27 years: 1) patients with rapidly progressive high-grade myopia; 2) those with slowly progressive high-grade myopia; 3) healthy individuals (controls). Groups 1 and 2 patients had elevated levels of lactic and pyruvic acids along with the decreased activity of the antioxidant system in the tear. Thus, a combination of indicators, such as a rise in hypoxia index by more than 1.0 and a decrease in the lacrimal fluid content of superoxide dismutase by more than 40%, may be a predictor of glaucoma in persons with rapidly progressive high-grade myopia.
authors.forename: G V
authors.initials: GV
authors.lastname: Shkrebets
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D018450:Disease Progression; D005500:Follow-Up Studies; D005901:Glaucoma / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D019344:Lactic Acid / Q000032:analysis*; D009216:Myopia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D011379:Prognosis; D019289:Pyruvic Acid / Q000032:analysis*; D012029:Refraction, Ocular; D012720:Severity of Illness Index; D013666:Tears / Q000737:chemistry*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D019344:Lactic Acid; D019289:Pyruvic Acid