title: Changing therapeutic landscape--the last decade.
abstract: Undoubtedly the most important event in the previous decade in lymphoma treatment was the establishment of immunotherapy as a prime modality. Addition of rituximab improves survival in almost every group of patients with CD20+ tumors. This has led to the appearance of a number of "me too" monoclonal antibodies (MoAbs) as well as MoAbs directed against other antigens whose usefulness remains to be proven during the next decade. We have also seen the raise and, probably unwarranted, fall of radioimmunotherapy. Conventional radiotherapy is losing ground. Regarding chemotherapy, the success of attempts to supplant R-CHOP-21 for front-line treatment of DLBCL with more dose-dense or dose-intense regimens remains doubtful and this issue is still unresolved. Bendamustine appeared as possibly the most effective cytotoxic agent for treatment of indolent lymphomas, while treatment of HL is becoming more tailored to prognostic features. This decade has also seen the advent of targeted drugs for lymphoma treatment. Their real impact will become known in the years to come. Finally, we may hope that advances in understanding the biology of lymphomas, made in the last decade, will help resolve remaining critical issues, treatment of T-NHLs and high-risk DLBCLs, being probably the most prominent.
authors.affiliation: Division of Hematology, Department of Internal Medicine, University Hospital Center Zagreb and Medical School, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia. aurer@mef.hr
authors.forename: Igor
authors.initials: I
authors.lastname: Aurer
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D018951:Antigens, CD20 / Q000096:biosynthesis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000069461:Bendamustine Hydrochloride; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004358:Drug Therapy / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008223:Lymphoma / Q000628:therapy*; D008495:Medical Oncology / Q000379:methods; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D016499:Radioimmunotherapy / Q000379:methods; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D018951:Antigens, CD20; D009588:Nitrogen Mustard Compounds; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D000069461:Bendamustine Hydrochloride; D011239:Prednisolone; D046988:Proteasome Endopeptidase Complex