title: Local progression after radiofrequency ablation for pulmonary metastases.
abstract: BACKGROUND
  Local treatment for pulmonary metastases is considered to be a reasonable treatment option in patients with oligometastatic disease. Percutaneous radio frequency ablation (RFA) has been reported as an alternative to surgery. Results of RFA for local control of pulmonary metastases were evaluated.
  
  
  METHODS
  All consecutive patients treated with RFA for pulmonary metastases (2004-2009) were included. RFA was performed percutaneously under computed tomographic guidance. Follow-up was scheduled at 1, 3, and 6 months after treatment and every 6 months thereafter. Major outcome parameters were local and any-site progression, complications, and survival.
  
  
  RESULTS
  Ninety pulmonary metastases were treated, in 46 patients at 65 sessions. Many patients had recurrent metastases after previous surgery (n = 36 of 46). Pneumothorax occurred in 34% (chest drain in 25%) and major complications in 6%. After median follow-up of 22 months (range, 2-65 months), 25 local progressions occurred after RFA; the 2-year local progression rate per lesion was 35%. Overall survival at 3 years was 69%.
  
  
  CONCLUSIONS
  Notwithstanding its relatively low morbidity, follow-up after RFA for pulmonary metastases shows a considerable rate of local progression. The role of local ablation techniques for long-term disease control in oligometastatic disease is discussed.
authors.affiliation: Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Erik M
authors.initials: EM
authors.lastname: von Meyenfeldt
authors.forename: Warner
authors.initials: W
authors.lastname: Prevoo
authors.forename: David
authors.initials: D
authors.lastname: Peyrot
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lai A Fat
authors.forename: Sjaak J A
authors.initials: SJ
authors.lastname: Burgers
authors.forename: Michel W
authors.initials: MW
authors.lastname: Wouters
authors.forename: Houke M
authors.initials: HM
authors.lastname: Klomp
mesh_terms: D000328:Adult; D000368:Aged; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local