title: Kaurane-type diterpenoids from Chromoleana odorata, their X-ray diffraction studies and potent α-glucosidase inhibition of 16-kauren-19-oic acid.
abstract: A new diterpenoid, 15-angeloyloxy-16,17-epoxy-19-kauronic acid (1), along with five known metabolites, 16-kauren-19-oic acid (2), 6'-hydroxy-2',3',4,4'-tetramethoxychalcone (3), isosakuranetin (4), acacetin (5), and kaempferide (6) was isolated from the organic extracts of the roots of Chromoleana odorata. Their structures were determined by spectroscopic evidences. The structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction studies. Compound 2 exhibited significant α-glucosidase inhibitory and antibacterial activities against Escherichia coli and Bacillus subtilis.
authors.affiliation: Department of Organic Chemistry, Higher Teachers' Training College, University of Yaounde I, PO Box 47, Yaounde, Cameroon. ramsay_kamdem@yahoo.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Wafo
authors.forename: Ramsay S T
authors.initials: RS
authors.lastname: Kamdem
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Shazia
authors.initials: S
authors.lastname: Anjum
authors.forename: Afshan
authors.initials: A
authors.lastname: Begum
authors.forename: Ogbole O
authors.initials: OO
authors.lastname: Oluyemisi
authors.forename: Shamsun N
authors.initials: SN
authors.lastname: Khan
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Xavier F
authors.initials: XF
authors.lastname: Etoa
authors.forename: Muhammed Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D036604:Chromolaena / Q000737:chemistry*; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification*; D065089:Glycoside Hydrolase Inhibitors; D008826:Microbial Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: C560478:15-angeloyloxy-16,17-epoxy-19-kauronic acid; C560479:16-kauren-19-oic acid; D000900:Anti-Bacterial Agents; D045786:Diterpenes, Kaurane; D065089:Glycoside Hydrolase Inhibitors