title: [Overexpression and its clinical significance of multi-drug resistance associated genes in lung cancer tissues].
abstract: BACKGROUND
  To investigate the expression level and its clinical significance of the multi-drug resistance (MDR) associated protein in lung cancer specimens.
  
  
  METHODS
  The expression levels of Pgp, MRP, GST-π and TopoII of MDR associated protein were detected in 60 lung cancer samples and 30 paracancerous tissues by S-P immunohistochemistry method.
  
  
  RESULTS
  The positive rate of Pgp, MRP, GST-π and Topo II in the lung cancer tissues was 40.0% (24/60), 61.7% (37/60), 45.0% (27/60) and 81.7% (49/60) respectively, which was significantly higher than those in paracancerous tissues (P < 0.01). No significant correlation was observed among the expression of multi-drug resistance-related protein and TNM staging, pathological type, cell differention and lymph node metastasis status (P > 0.05).
  
  
  CONCLUSIONS
  Lung cancer has overexpression of multi-drug resistant-related genes during the oncogenesis. Combined detection of these genes may be useful for guiding the lung cancer chemotherapy.
authors.affiliation: Department of Chest Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R.China.
authors.forename: Guoren
authors.initials: G
authors.lastname: Li
authors.forename: Jianhua
authors.initials: J
authors.lastname: Dai
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Wang
authors.forename: Guanghui
authors.initials: G
authors.lastname: Chen
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liu
authors.forename: Fulu
authors.initials: F
authors.lastname: Miao
authors.forename: Ling
authors.initials: L
authors.lastname: Bai
authors.forename: Yulin
authors.initials: Y
authors.lastname: Chen