title: Psoriasis: comorbidities and associations.
abstract: Psoriasis is a chronic, genetic, inflammatory skin disease affecting approximately 2% of the population worldwide. Over the past decade, multiple studies have shown that not only is there an association between psoriasis and psoriatic arthritis, depression, and substance abuse, but psoriasis patients also have a higher incidence of obesity, diabetes, heart disease and stroke. In addition, and more concerning, young psoriatic patients particularly those with more severe disease are at an increased mortality risk even when controlling for these factors. The systemic inflammation in psoriasis generates elevation of C-reactive protein, homocysteine, and inflammatory cytokines such as TNF-a, IL-6, IL-17, IL-20, IL-22, and IL-23, which may contribute to the overall morbidity and mortality in these patients. Within this article we will discuss the associations between psoriasis and multiple systemic health problems.
authors.affiliation: Department of Dermatology, Baylor University Medical Center, Dallas, TX 75246, USA.
authors.forename: E
authors.initials: E
authors.lastname: Farley
authors.forename: A
authors.initials: A
authors.lastname: Menter
mesh_terms: D015535:Arthritis, Psoriatic / Q000453:epidemiology; D001327:Autoimmune Diseases / Q000453:epidemiology; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002986:Clinical Trials as Topic; D015897:Comorbidity; D016207:Cytokines / Q000378:metabolism; D003863:Depression / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005234:Fatty Liver / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology; D008171:Lung Diseases / Q000453:epidemiology; D024821:Metabolic Syndrome / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000453:epidemiology; D011565:Psoriasis / Q000453:epidemiology*; D012042:Registries; D019966:Substance-Related Disorders / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D016207:Cytokines