title: Epidemiology and management of infectious complications of contemporary management of chronic leukemias.
abstract: This is a review of the epidemiology and management of infectious complications of contemporary management of chronic leukemias. Patients with chronic leukemias typically are affected by nuisance infections due to the underlying hematologic condition, particularly hypogammaglobulinemia in CLL patients. With active treatment, particularly those agents that cause defects in cell-mediated immunity, the incidence of opportunistic infections increases although endogenous bacterial, mycobacterial, and fungal infections also occur. Exogenous treatment with immunoglobulin and antimicrobial prophylaxis, particularly anti-Pneumocystis prophylaxis, may be indicated in select patients. Routine vaccinations should be maintained in these patients and vaccination early in the course of treatment may result in improve protection.
authors.affiliation: Division of Infectious Disease and International Medicine, Department of Medicine of the University of Minnesota, Minneapolis, MN, MMC 250, 420 Delaware Street S.E. Minneapolis, MN 55455, USA. vanbu004@umn.edu
authors.forename: Jo-Anne H
authors.initials: JA
authors.lastname: Young
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology*; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D013997:Time Factors; D014611:Vaccination
chemical_list: D000970:Antineoplastic Agents