title: Formation and regulation of fullerene-incorporation in liposomes under the phase transition temperature.
abstract: The fullerene-exchange reaction from a cyclodextrin cavity to liposomes represents one of the best methods to prepare lipid membrane-incorporated [70]fullerenes (C(70)). The C(70)-exchange reaction occurred completely at temperatures above the phase transition temperature (T(m)) of the liposomes; however, lowering the temperature to below the T(m) led to C(70) aggregation outside the liposomes. This observation has limited the development of more functional LMIC(70) using a variety of liposome compositions. In this paper, this reaction was found to occur efficiently by the addition of small amounts of lipids bearing a π-moiety. The π-moieties act as a gate when hydrophobic C(70) migrates into the hydrophilic liposome surface. Therefore, the π-moieties should exist in the polar head groups of the lipids and the C(70)-exchange reaction can be controlled by pH.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan. aikeda@ms.naist.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kawai
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kikuchi
authors.forename: Motofusa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Uto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hori
mesh_terms: D037741:Fullerenes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes; D015394:Molecular Structure; D010316:Particle Size; D013499:Surface Properties; D044366:Transition Temperature
chemical_list: D037741:Fullerenes; D008081:Liposomes