title: Polymeric disinfectant nanocapsules: effect of molecular weight of poly(methyl acrylate).
abstract: Poly(methyl acrylate) (PMA) of various weight average molecular weights (Mw) were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHD-PMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the Mw of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Phyathai, Bangkok 10400, Thailand.
authors.forename: Saovaree
authors.initials: S
authors.lastname: Tanpantree
authors.forename: Pakorn
authors.initials: P
authors.lastname: Opaprakasit
authors.forename: Duangporn
authors.initials: D
authors.lastname: Polpanich
authors.forename: Srung
authors.initials: S
authors.lastname: Smanmoo
authors.forename: Pramuan
authors.initials: P
authors.lastname: Tangboriboonrat
mesh_terms: D004202:Disinfectants / Q000494:pharmacology; D016503:Drug Delivery Systems; D054709:Lecithins / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D008970:Molecular Weight; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D004202:Disinfectants; D054709:Lecithins; D053769:Nanocapsules; D011109:Polymethacrylic Acids; C500651:poly(MPC-co-MA); D010767:Phosphorylcholine