title: Factors associated with tuberculosis as an AIDS-defining disease in an immigration setting.
abstract: BACKGROUND
  Immigration can affect the evolution of TB as an AIDS-defining disease (AIDS-TB).
  
  
  METHODS
  The Barcelona AIDS register for 1994-2005 was analyzed, and the global characteristics of AIDS-TB and AIDS-non-TB cases were compared. The Mantel-Haenszel test was used in the trend analysis, and logistic regression was used in the multivariate analysis.
  
  
  RESULTS
  Of the 3600 cases studied, 1130 had both AIDS and TB. A declining trend in AIDS-TB rates was observed in both sexes among both immigrants and native residents. The percentage of AIDS-TB was significantly higher among immigrants (P = 0.02). The number of cases among immigrants remained constant over the period of study, but decreased among native residents. The sociodemographic and immunological characteristics associated with TB were male sex, age younger than 36 years, inner city residence, a record of incarceration, greater than 200 CD4+ T-cells/mm(3), injecting drug use, heterosexual sex, and immigration from Latin America, the Caribbean, or sub-Saharan Africa.
  
  
  CONCLUSIONS
  The incidence of TB as an AIDS-defining disease decreased in Barcelona during a recent 10-year period in both native and immigrant populations. However, immigrants remain a high-risk group for AIDS-TB and should be targeted for surveillance and control of both diseases.
authors.affiliation: IBIOMED. Área de Medicina Preventiva y Salud Pública. Universidad de León. CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Martín
authors.forename: Patricia
authors.initials: P
authors.lastname: García de Olalla
authors.forename: Angels
authors.initials: A
authors.lastname: Orcau
authors.forename: Joan A
authors.initials: JA
authors.lastname: Caylà
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology*; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology*; D055815:Young Adult