title: Microanatomical effects of ethanolic extract of Cola nitida on the stomach mucosa of adult Wistar rats.
abstract: The study investigated the microanatomical effects of the extracts of Cola nitida on the stomach mucosa of adult male Wistar rats. Twenty adult male wistar rats were randomly divided into four equal groups of A, B, C and D (n = 5). Animals in experimental groups B, C and D were given 600 mg/kg body weight of crude extract of Cola nitida each by oral intubation for five, seven and nine consecutive days respectively, while group A (control) received equivalent volume of distilled water. Twenty four hrs after the last administration, the animals were sacrificed; tissues were harvested and fixed in 10% formol saline for histological analysis. The study revealed necrotized surface epithelium, degenerated gastric mucosa, and loss of glandular elements in the stomachs of experimental groups' vis-à-vis the control group. These observations were days-dependent; as those groups which received the extract for higher number of days were seen to be adversely affected. In conclusion, Cola nitida at 600 mg/kg body weight can cause gastric lesion in animals. This lesion may be pronounced if the administration continued for days. Cola nitida should, therefore, be taken with caution to avoid gastric complications.
authors.affiliation: Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Bowen University, Osun state, Nigeria. davidofus234@yahoo.com
authors.forename: Gideon B
authors.initials: GB
authors.lastname: Ojo
authors.forename: Polycarp U
authors.initials: PU
authors.lastname: Nwoha
authors.forename: David A
authors.initials: DA
authors.lastname: Ofusori
authors.forename: Sunday A
authors.initials: SA
authors.lastname: Ajayi
authors.forename: Samson A
authors.initials: SA
authors.lastname: Odukoya
authors.forename: Victor O
authors.initials: VO
authors.lastname: Ukwenya
authors.forename: Olubayode
authors.initials: O
authors.lastname: Bamidele
authors.forename: Olumide A
authors.initials: OA
authors.lastname: Ojo
authors.forename: Oladele P
authors.initials: OP
authors.lastname: Oluwayinka
mesh_terms: D000818:Animals; D030221:Cola / Q000009:adverse effects / Q000737:chemistry*; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008853:Microscopy; D009754:Nuts; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D010936:Plant Extracts; D000431:Ethanol