title: Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.
abstract: C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation, and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence, and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.
authors.affiliation: Max Delbrueck Center for Molecular Medicine, Berlin, Germany. aleutz@mdc-berlin.de
authors.forename: Achim
authors.initials: A
authors.lastname: Leutz
authors.forename: Ole
authors.initials: O
authors.lastname: Pless
authors.forename: Michael
authors.initials: M
authors.lastname: Lappe
authors.forename: Gunnar
authors.initials: G
authors.lastname: Dittmar
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Kowenz-Leutz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001120:Arginine / Q000235:genetics / Q000378:metabolism*; D001665:Binding Sites / Q000235:genetics; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002468:Cell Physiological Phenomena / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D008239:Lysine / Q000235:genetics / Q000378:metabolism*; D008745:Methylation; D008969:Molecular Sequence Data; D009154:Mutation; D010766:Phosphorylation; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D017386:Sequence Homology, Amino Acid
chemical_list: D022763:CCAAT-Enhancer-Binding Protein-alpha; D022782:CCAAT-Enhancer-Binding Protein-beta; D020033:Protein Isoforms; D001120:Arginine; D008239:Lysine