title: A case report of vinorelbine monotherapy-related acute bronchospasm and non-ST elevation acute coronary syndrome.
abstract: Vinorelbine is a semi-synthetic vinca-alkaloid with a broad spectrum anti-tumor activity. The dose-limiting toxicity of vinorelbine is neutropenia and leucopenia which is seen in majority of the patients. The previous case reports on the cardiac toxicity occurred mainly in combination therapy of vinorelbine with cisplatin or carboplatin. We offer evidence that acute coronary syndrome and resultant diastolic heart failure developed as a result of acute bronchospasm due to intravenous vinorelbine monotherapy.
authors.affiliation: Division of Cardiovascular Medicine, University Hospitals/Case Medical Center, Cleveland, OH, USA. page124@hotmail.com
authors.forename: Anil K
authors.initials: AK
authors.lastname: Goli
authors.forename: Mohammed N
authors.initials: MN
authors.lastname: Osman
authors.forename: Madhav
authors.initials: M
authors.lastname: Koduri
authors.forename: Ryland P
authors.initials: RP
authors.lastname: Byrd
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Roy
mesh_terms: D054058:Acute Coronary Syndrome / Q000139:chemically induced*; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001986:Bronchial Spasm / Q000139:chemically induced*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D014747:Vinblastine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine