title: [Investigation of postconditioning in intestinal ischemia-reperfusion experimental models].
abstract: BACKGROUND
  The ischemic-reperfusion injury of the intestine, which occurs as a consequence of circulatory redistribution or occlusion of the superior mesenteric artery, is associated with high mortality rates. Postconditioning may reduce ischemic-reperfusion damage in such cases. Effects of this new surgical method were investigated in rats.
  
  
  METHODS
  Male Wistar rats underwent 60 minutes of superior mesenteric artery occlusion in four groups: sham-operated, control and two postconditioned groups with different algorithms. Postconditioning was performed immediately at the beginning of reperfusion, by repetitive cycles of reperfusion and reocclusion. 3 cycles of 1 minute and 6 cycles of 10 seconds were applied according to groups. Intestinal microcirculation was followed by laser Doppler flowmetry. Blood and tissue samples were taken after 60 minutes of reperfusion. Histological analayses of the small intestine, measurement of serum necroenzyme levels and IL-6, mesenterial venous blood gas analyses were preformed and antioxidant state of the mucosa was investigated.
  
  
  RESULTS
  The microcirculation during the reperfusion showed significant improvement in both postconditioned groups. Histological damage, necroenzyme and IL-6 levels were significantly reduced, while antioxidant state was improved in the postconditioned groups.
  
  
  CONCLUSIONS
  Postconditioning was capable of increasing the guts chance to survive ischemic-reperfusion injury caused by superior mesenteric artery occlusion.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. sz. Sebészeti Klinika 1082 Budapest Üllői út 78.
authors.forename: Olivér
authors.initials: O
authors.lastname: Rosero
authors.forename: Péter
authors.initials: P
authors.lastname: Onody
authors.forename: Rita
authors.initials: R
authors.lastname: Stangl
authors.forename: Viktor
authors.initials: V
authors.lastname: Hegedus
authors.forename: Gábor
authors.initials: G
authors.lastname: Lotz
authors.forename: Anna
authors.initials: A
authors.lastname: Blázovics
authors.forename: Péter
authors.initials: P
authors.lastname: Kupcsulik
authors.forename: Attila
authors.initials: A
authors.lastname: Szijártó
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004386:Duodenum / Q000098:blood supply; D007082:Ileum / Q000098:blood supply; D015850:Interleukin-6 / Q000097:blood; D007413:Intestinal Mucosa / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D007421:Intestine, Small / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D057775:Ischemic Postconditioning; D007583:Jejunum / Q000098:blood supply; D017078:Laser-Doppler Flowmetry; D008297:Male; D017538:Mesenteric Artery, Superior / Q000473:pathology*; D008833:Microcirculation; D009336:Necrosis / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015850:Interleukin-6