title: The effect of furosemide on left atrial pressure in dogs with mitral valve regurgitation.
abstract: BACKGROUND
  The effects of furosemide on left atrial pressure (LAP) in dogs with mitral regurgitation (MR) have not been documented in a quantitative manner and between different routes of administration.
  
  
  OBJECTIVE
  To document LAP and echocardiographic parameters in MR dogs administered furosemide IV or PO, in order to document changes in LAP after furosemide treatment.
  
  
  METHODS
  Five healthy Beagle dogs (3 males and 2 females; aged 2 years) were used.
  
  
  METHODS
  Experimental, cross-over, and interventional study. LAP was measured before the administration of furosemide, and 30 minutes, 1, 1.5, 2, 3, 4, 5, 6, 8, 12, and 24 hours after administration. Furosemide 1, 2, or 4 mg/kg IV, PO or placebo was administered.
  
  
  RESULTS
  LAP was significantly decreased with all administrations of furosemide but not after placebo (P < .05, respectively). The max reduction was observed 1 hour (1 mg/kg IV, 15.04 ± 7.02 mmHg), 3 hours (2, 4 mg/kg IV, 13.28 ± 8.01, 9.23 ± 4.92 mmHg), 4 hours (1 mg/kg PO, 14.68 ± 11.51 mmHg), and 5 hours (2, 4 mg/kg PO, 13.19 ± 10.52, 10.70 ± 7.69 mmHg). E wave and E/Ea were significantly decreased corresponding to the reduction of LAP after administration of 2 and 4 mg/kg (P < .05, respectively).
  
  
  CONCLUSIONS
  LAP was decreased in proportion to the dosage of furosemide, which did not significantly differ between IV and PO of the same dosages. E wave and E/Ea might be useful for the treatment evaluation of furosemide.
authors.affiliation: Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agriculture and Technology, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: L
authors.initials: L
authors.lastname: Hamabe
authors.forename: D
authors.initials: D
authors.lastname: Aytemiz
authors.forename: H
authors.initials: H
authors.lastname: Huai-Che
authors.forename: R
authors.initials: R
authors.lastname: Fukushima
authors.forename: N
authors.initials: N
authors.lastname: Machida
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D016279:Atrial Function, Left / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D018592:Cross-Over Studies; D004232:Diuretics / Q000008:administration & dosage* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005665:Furosemide / Q000008:administration & dosage* / Q000627:therapeutic use; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D008944:Mitral Valve Insufficiency / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D004232:Diuretics; D005665:Furosemide