title: The pursuit of oncotargets through understanding defective cell regulation.
abstract: More effective anticancer agents are essential, as has too often been demonstrated by the paucity of therapeutics which preserve life. Their discovery is very difficult. Many approaches are being applied, from testing folk medicines to automated high throughput screening of large chemical libraries. Mutations in cancer cells create dysfunctional regulatory systems. This Perspective summarizes an approach to applying defective molecular control mechanisms as oncotargets on which drug discoveries against cancer can be based.
authors.affiliation: University of California, Irvine Biological Chemistry, 140 Sprague Hall, 839 Health Sciences Rd, Irvine, CA 92697-1700.
authors.forename: Meng
authors.initials: M
authors.lastname: Qiao
authors.affiliation: Institutes of Biomedical Sciences, Fudan University,130 Dong An Road, Box 281, Shanghai, China 20003.
authors.forename: Qian
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Dana-Farber Cancer Institute, 44 Binney St, Boston, MA. 02115.
authors.forename: Arthur B
authors.initials: AB
authors.lastname: Pardee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D048708:Cell Growth Processes / Q000235:genetics; D002470:Cell Survival / Q000235:genetics / Q000502:physiology; D032882:Comprehension; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins