title: Association between the M268T polymorphism in the angiotensinogen gene and essential hypertension in a South Indian population.
abstract: Essential hypertension is a complex multifactorial disease caused by interactions between genetic and environmental factors. It is an independent determinant of cardiovascular risk. The main aim of this study was to investigate the possible influence of angiotensinogen M268T polymorphisms on hypertension in two endogamous caste populations of South India. Systolic and diastolic blood pressure, anthropometric variables, and lipid profiles were assessed. Direct sequencing of PCR products was adopted for genotyping. This polymorphism was found to be in Hardy-Weinberg equilibrium in the patients and controls of both populations. Binary odds ratios showed significant association between the M268T polymorphism and hypertension in both populations. Multivariate analysis revealed significant differences in body mass index, chest girth, calf circumference, skinfold measurements, total cholesterol, and triglyceride levels between these genotypes in the Gavara and Vaishya populations. These data further support the hypothesis that hypertension is influenced by the AGT M268T polymorphism.
authors.affiliation: Anthropological Survey of India, Government of India, Ministry of Culture, Kolkata.
authors.forename: M
authors.initials: M
authors.lastname: Gopi Chand
authors.forename: J
authors.initials: J
authors.lastname: Srinath
authors.forename: R S
authors.initials: RS
authors.lastname: Rao
authors.forename: Bhaskar V K S
authors.initials: BV
authors.lastname: Lakkakula
authors.forename: Satish
authors.initials: S
authors.lastname: Kumar
authors.forename: V R
authors.initials: VR
authors.lastname: Rao
mesh_terms: D000328:Adult; D000808:Angiotensinogen / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007194:India; D008075:Lipoproteins, HDL / Q000097:blood / Q000235:genetics; D008077:Lipoproteins, LDL / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012885:Skinfold Thickness; D014280:Triglycerides / Q000097:blood / Q000235:genetics
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D000808:Angiotensinogen; D002784:Cholesterol