title: The consequence of immune suppressive cells in the use of therapeutic cancer vaccines and their importance in immune monitoring.
abstract: Evaluating the number, phenotypic characteristics, and function of immunosuppressive cells in the tumor microenvironment and peripheral blood could elucidate the antitumor immune response and provide information to evaluate the efficacy of cancer vaccines. Further studies are needed to evaluate the correlation between changes in immunosuppressive cells and clinical outcomes of patients in cancer vaccine clinical trials. This paper focuses on the role of T-regulatory cells, myeloid-derived suppressor cells, and tumor-associated macrophages in cancer and cancer immunotherapy and their role in immune monitoring.
authors.affiliation: Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Matteo
authors.initials: M
authors.lastname: Vergati
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Schlom
authors.forename: Kwong Y
authors.initials: KY
authors.lastname: Tsang
mesh_terms: D019496:Cancer Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D007167:Immunotherapy; D008264:Macrophages / Q000166:cytology / Q000276:immunology; D015166:Monitoring, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology
chemical_list: D019496:Cancer Vaccines