title: Coordination of glucose and glutamine utilization by an expanded Myc network.
abstract: Glucose and glutamine are the most abundant circulating nutrients and support the growth and proliferation of all cells, in particular rapidly growing and dividing cancer cells. Several recent studies implicate an expanded Myc network in how cells sense and utilize both glucose and glutamine. These studies reveal an unappreciated coordination between glycolysis and glutaminolysis, potentially providing new targets for therapeutic intervention in cancer.
authors.affiliation: Huntsman Cancer Institute, University of Utah, Salt Lake City, USA.
authors.forename: Mohan R
authors.initials: MR
authors.lastname: Kaadige
authors.forename: Marc G
authors.initials: MG
authors.lastname: Elgort
authors.forename: Donald E
authors.initials: DE
authors.lastname: Ayer
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D005973:Glutamine; D005947:Glucose