title: Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters.
abstract: SERS nanotags have been prepared to accomplish the multiplex detection of cancer cells. Herein we evaluated the adequacy of lipoic acid-containing cyanine derivatives (Cy3LA and Cy5LA) to function as multiplex partners with a triphenylmethine Raman reporter (B2LA) under a single excitation wavelength. SERS experiments enabled the multiplex recognition of two different cancer cells with antibody-conjugated nanotags that were derivatized with optimized cyanine and triphenylmethine reporters.
authors.affiliation: Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667 Singapore.
authors.forename: Kaustabh Kumar
authors.initials: KK
authors.lastname: Maiti
authors.forename: Animesh
authors.initials: A
authors.lastname: Samanta
authors.forename: Marc
authors.initials: M
authors.lastname: Vendrell
authors.forename: Kiat-Seng
authors.initials: KS
authors.lastname: Soh
authors.forename: Malini
authors.initials: M
authors.lastname: Olivo
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000906:Antibodies / Q000276:immunology; D002232:Carbocyanines / Q000737:chemistry* / Q000378:metabolism; D045744:Cell Line, Tumor; D002469:Cell Separation / Q000379:methods*; D004396:Coloring Agents / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D049329:Nanostructures; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
chemical_list: D000906:Antibodies; D002232:Carbocyanines; D004396:Coloring Agents; D010455:Peptides; C036436:methinin