title: Anti-inflammatory effects of anti-hypertensive agents: influence on interleukin-1β secretion by peripheral blood polymorphonuclear leukocytes from patients with essential hypertension.
abstract: The effects of clinically relevant concentrations of anti-hypertensive agents on lipopolysaccharide (LPS)-induced interleukin-1beta (IL-1β) secretion by polymorphonuclear leukocytes (PMNs) were investigated in vitro. Lipopolysaccharide-induced secretion of IL-1β by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed. IL-1β secretion by PMNs markedly increased in hypertensive patients versus normotensive subjects. Losartan, captopril, and amlodipine caused a concentration-dependent attenuation of IL-1β levels in both groups. Losartan, captopril, and amlodipine demonstrated marked in vitro anti-inflammatory effects at clinically relevant serum concentrations but atenolol and hydrochlorothiazide did not.
authors.affiliation: Department of Biology, Science & Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Farkhondeh
authors.initials: F
authors.lastname: Nemati
authors.forename: Nahid
authors.initials: N
authors.lastname: Rahbar-Roshandel
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Hosseini
authors.forename: Massoud
authors.initials: M
authors.lastname: Mahmoudian
authors.forename: Massoumeh
authors.initials: M
authors.lastname: Shafiei
mesh_terms: D000328:Adult; D017311:Amlodipine / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001262:Atenolol / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood*; D008070:Lipopolysaccharides / Q000494:pharmacology; D019808:Losartan / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D006852:Hydrochlorothiazide; D017311:Amlodipine; D001262:Atenolol; D002216:Captopril; D019808:Losartan