title: Placental pathology is associated with illness severity in preterm infants in the first twenty-four hours after birth.
abstract: BACKGROUND
  Placental pathology is associated with long-term neurological morbidity. Little is known about the association of placental pathology and illness severity directly after birth in preterm infants.
  
  
  OBJECTIVE
  To determine the association between placental pathology and illness severity in preterm infants during the first 24 h after birth.
  
  
  METHODS
  Placentas of 40 preterm infants, born after singleton pregnancies (gestational age 25.4-31.7 weeks, birth weight 560-2250 g) were assessed for histopathology. Illness severity was measured using the Score of Neonatal Acute Physiology Perinatal Extension (SNAPPE). A high SNAPPE reflects high illness severity.
  
  
  RESULTS
  Examination of the 40 placentas revealed: pathology consistent with maternal vascular underperfusion (MVU) (n=24), ascending intrauterine infection (AIUI) (n=17), villitis of unknown aetiology (VUE) (n=6), foetal thrombotic vasculopathy (FTV) (n=6), elevated nucleated red blood cells (NRBCs) (n=6), and chronic deciduitis (n=10). SNAPPE ranged from 1 to 53 (median 10). Infants with elevated NRBCs had a higher SNAPPE than infants without elevated NRBCs (median 30 vs. 10, p=0.014). The same was found for the presence of FTV (median 30 vs. 10, p=0.019). No relation existed between SNAPPE and the other placental pathologies.
  
  
  CONCLUSIONS
  Elevated NRBCs and FTV were associated with higher illness severity during the first 24 h after birth in preterm infants. Ascending intrauterine infection was not associated with high illness severity.
authors.affiliation: Division of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. a.m.roescher@student.rug.nl
authors.forename: A M
authors.initials: AM
authors.lastname: Roescher
authors.forename: M M
authors.initials: MM
authors.lastname: Hitzert
authors.forename: A
authors.initials: A
authors.lastname: Timmer
authors.forename: E A
authors.initials: EA
authors.lastname: Verhagen
authors.forename: J J H M
authors.initials: JJ
authors.lastname: Erwich
authors.forename: A F
authors.initials: AF
authors.lastname: Bos
mesh_terms: D002657:Child Development; D004900:Erythroblasts / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D008297:Male; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000473:pathology*; D049590:Postpartum Period; D011247:Pregnancy; D047928:Premature Birth; D011379:Prognosis