title: Genetic control of igG2a production in the response to sheep erythrocytes.
abstract: A low IgG2a response in B10 mice during the primary response to sheep red blood cells (SRBC) is described. Analysis of the response in B10 × BALB/c hybrid progenies and in congenic strains indicates that this low response is a dominant phenotype placed under the control of a single Mendelian gene or a group of closely linked genes. This gene(s) is neither linked to CH allotypes orH2 haplotypes, nor is it sex-linked. It can be considered as an isotype- and antigenspecific regulatory gene of the immune response.
authors.affiliation: Unitéd'Immunodifférenciation, Institut de Recherche en Biologie Moleculaire C.N.R.S., Université Paris 7, Tour 43, 2 Place Jussieu, 75221, Paris Cédex 05, France.
authors.forename: M
authors.initials: M
authors.lastname: Seman
authors.forename: V
authors.initials: V
authors.lastname: Zilberfarb
authors.forename: M
authors.initials: M
authors.lastname: Stanislawski
authors.forename: J M
authors.initials: JM
authors.lastname: Dubert