title: Nuclear quadrupole resonance: a technique to control hydration processes in the pharmaceutical industry.
abstract: Pharmaceuticals can exist in many solid forms, which can have different physical and chemical properties. These solid forms include polymorphs, solvates, amorphous, and hydrates. Particularly, hydration process can be quite common since pharmaceutical solids can be in contact with water during manufacturing process and can also be exposed to water during storage. In the present work, it is proved that NQR technique is capable of detecting different hydrated forms not only in the pure raw material but also in the final product (tablets), being in this way a useful technique for quality control. This technique was also used to study the dehydration process from pentahydrate to trihydrate.
authors.affiliation: Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba, IFEG-CONICET, Ciudad Universitaria, 5000 Córdoba, Argentina.
authors.forename: Silvina
authors.initials: S
authors.lastname: Limandri
authors.forename: Claudia
authors.initials: C
authors.lastname: Visñovezky
authors.forename: Silvina C
authors.initials: SC
authors.lastname: Pérez
authors.forename: Clemar A
authors.initials: CA
authors.lastname: Schurrer
authors.forename: Alberto E
authors.initials: AE
authors.lastname: Wolfenson
authors.forename: Maribel
authors.initials: M
authors.lastname: Ferro
authors.forename: Silvia L
authors.initials: SL
authors.lastname: Cuffini
authors.forename: Joel Gonçalves
authors.initials: JG
authors.lastname: de Souza
authors.forename: F Armani
authors.initials: FA
authors.lastname: Aguiar
authors.forename: C Masetto
authors.initials: CM
authors.lastname: de Gaitani
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D004008:Diclofenac / Q000737:chemistry; D004345:Drug Industry; D014867:Water / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014867:Water; D004008:Diclofenac