title: [Polymorphism of IL1α and IL1β genes and bacterial invasion in patients with chronic generalized periodontitis].
abstract: Researchers studied polymorphism of IL-1α and IL-1β genes among patients of different ages with severe chronic generalized periodontitis and people with healthy periodontium. The study demonstrated a correlation between high frequency of genetic polymorphism in IL-1α -899 and IL-1β +3953 loci and development of severe periodontitis among patients less than 35 years of age, as well as markers of P. intermedia, T. denticola, HSV1 and EBV in periodontal pocket.
authors.forename: V N
authors.initials: VN
authors.lastname: Tsarev
authors.forename: E N
authors.initials: EN
authors.lastname: Nikolaeva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics* / Q000382:microbiology*; D011110:Polymorphism, Genetic; D018713:Prevotella intermedia / Q000302:isolation & purification; D048373:Treponema denticola / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D053582:Interleukin-1alpha; D053583:Interleukin-1beta