title: [Clinical features and treatment of seventh day syndrome following living donor liver transplantation].
abstract: OBJECTIVE
  To investigate the clinic features and treatment of seventh day syndrome (7DS) following living donor liver transplantation (LDLT).
  
  
  METHODS
  From January 2002 to March 2009, 8 patients were diagnosed with 7DS following LDLT. A retrospective analysis was made on the clinical data containing liver and renal functions, coagulation function, sonographic and histological features and effectiveness of the treatments.
  
  
  RESULTS
  Rapid deterioration of liver function happened 1-2 weeks after operations, followed by renal dysfunction. There was a reduction of velocity or bidirectional blood flow in the portal vein. Massive coagulative necrosis with disruption of lobular architecture occurred in 3.3% of cases, with a mortality of 87.5%. The steroid pulse and OKT3 (anti-CD3 antibody) therapy showed minimal effects. Prolonged application of i.v. methylprednisolone may be helpful with the delay of 7DS.
  
  
  CONCLUSIONS
  The 7DS may be an immune-mediated graft failure. The prevention and control of 7DS is difficult due to lack of research evidence.
authors.affiliation: Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Zhong-we
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Wan-hong
authors.initials: WH
authors.lastname: Yin
authors.forename: Li-jing
authors.initials: LJ
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Kang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
authors.forename: Li-li
authors.initials: LL
authors.lastname: Cao
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D017093:Liver Failure / Q000097:blood / Q000209:etiology / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality; D051437:Renal Insufficiency / Q000209:etiology*; D012189:Retrospective Studies; D013577:Syndrome