title: Engineering O-glycosylation points in non-extended peptides: implications for the molecular recognition of short tumor-associated glycopeptides.
abstract: The ties that bind: The incorporation of non-natural residues in the peptide backbone allows the design of O-glycosylation points in helical segments. This strategy could help to modulate the binding properties between glycopeptides and their protein receptors, such as lectins and antibodies.
authors.affiliation: Departmento de Química, Universidad de La Rioja, Madre de Dios, 51, 26006 Logroño, Spain. francisco.corzana@unirioja.es
authors.forename: Francisco
authors.initials: F
authors.lastname: Corzana
authors.forename: Jesús H
authors.initials: JH
authors.lastname: Busto
authors.forename: Filipa
authors.initials: F
authors.lastname: Marcelo
authors.forename: Marisa
authors.initials: M
authors.lastname: García de Luis
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Asensio
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Martín-Santamaría
authors.forename: Jesús
authors.initials: J
authors.lastname: Jiménez-Barbero
authors.forename: Alberto
authors.initials: A
authors.lastname: Avenoza
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Peregrina
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000378:metabolism; D006020:Glycopeptides / Q000737:chemistry* / Q000378:metabolism; D006031:Glycosylation; D037102:Lectins / Q000737:chemistry / Q000378:metabolism; D018396:Mucin-1 / Q000737:chemistry / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary; D013816:Thermodynamics
chemical_list: D000906:Antibodies; D006020:Glycopeptides; D037102:Lectins; D018396:Mucin-1