title: Pharmacokinetics of oxymorphone in cats.
abstract: This study reports the pharmacokinetics of oxymorphone in spayed female cats after intravenous administration. Six healthy adult domestic shorthair spayed female cats were used. Oxymorphone (0.1 mg/kg) was administered intravenously as a bolus. Blood samples were collected immediately prior to oxymorphone administration and at various times up to 480 min following administration. Plasma oxymorphone concentrations were determined by liquid chromatography-mass spectrometry, and plasma oxymorphone concentration-time data were fitted to compartmental models. A three-compartment model, with input in and elimination from the central compartment, best described the disposition of oxymorphone following intravenous administration. The apparent volume of distribution of the central compartment and apparent volume of distribution at steady state [mean ± SEM (range)] and the clearance and terminal half-life [harmonic mean ± jackknife pseudo-SD (range)] were 1.1 ± 0.2 (0.4-1.7) L/kg, 2.5 ± 0.4 (2.4-4.4) L/kg, 26 ± 7 (18-38) mL/min.kg, and 96 ± 49 (62-277) min, respectively. The disposition of oxymorphone in cats is characterized by a moderate volume of distribution and a short terminal half-life.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA.
authors.forename: K T
authors.initials: KT
authors.lastname: Siao
authors.forename: B H
authors.initials: BH
authors.lastname: Pypendop
authors.forename: S D
authors.initials: SD
authors.lastname: Stanley
authors.forename: J E
authors.initials: JE
authors.lastname: Ilkiw
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D002415:Cats / Q000097:blood*; D002853:Chromatography, Liquid / Q000662:veterinary; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D016018:Least-Squares Analysis; D016014:Linear Models; D008657:Metabolic Clearance Rate; D010111:Oxymorphone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D053719:Tandem Mass Spectrometry / Q000662:veterinary
chemical_list: D000701:Analgesics, Opioid; D010111:Oxymorphone