title: A novel approach to overcome temozolomide resistance in glioma and melanoma: Inactivation of MGMT by gene therapy.
abstract: Malignant glioma is the most common primary brain tumor. Malignant melanoma is the most malignant of skin tumor. The two malignancies are poorly responsive to conventional treatment regimens such as chemotherapy. Temozolomide (TMZ) is a DNA-alkylating agent used for the treatment of glioma, astrocytoma, and melanoma. Resistance to alkylating agents such as TMZ correlates with increased expression of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). Several studies in animal models have demonstrated that decreasing MGMT level with gene therapy could overcome TMZ resistance and enhance tumor cell death. In the present review, we provide an overview of recent advances in this field.
authors.affiliation: Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou 221002, China.
authors.forename: Guan
authors.initials: G
authors.lastname: Jiang
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Wei
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Pei
authors.forename: Yong
authors.initials: Y
authors.lastname: Xin
authors.forename: Yan-Qun
authors.initials: YQ
authors.lastname: Liu
authors.forename: Jun-Nian
authors.initials: JN
authors.lastname: Zheng
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D015254:DNA Modification Methylases / Q000037:antagonists & inhibitors* / Q000235:genetics; D045643:DNA Repair Enzymes / Q000037:antagonists & inhibitors* / Q000235:genetics; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D020868:Gene Silencing; D015316:Genetic Therapy / Q000379:methods*; D005910:Glioma / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000201:enzymology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D000077204:Temozolomide; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics
chemical_list: D018906:Antineoplastic Agents, Alkylating; D025521:Tumor Suppressor Proteins; D003606:Dacarbazine; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes; D000077204:Temozolomide