title: Bunodosine 391: an analgesic acylamino acid from the venom of the sea anemone Bunodosoma cangicum.
abstract: A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent analgesic effect. This effect was not altered by naloxone (an opioid receptor antagonist), but was completely reversed by methysergide (a serotonin receptor antagonist), indicating that the effect is mediated by activation of serotonin receptors.
authors.affiliation: Biotechnology Center, Nuclear and Energy Research Institute, São Paulo 05508-000, Brazil.
authors.forename: André J
authors.initials: AJ
authors.lastname: Zaharenko
authors.forename: Gisele
authors.initials: G
authors.lastname: Picolo
authors.forename: Wilson A
authors.initials: WA
authors.lastname: Ferreira
authors.forename: Takanori
authors.initials: T
authors.lastname: Murakami
authors.forename: Kohei
authors.initials: K
authors.lastname: Kazuma
authors.forename: Masaru
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Yara
authors.initials: Y
authors.lastname: Cury
authors.forename: José C
authors.initials: JC
authors.lastname: de Freitas
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Satake
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Konno
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D003064:Cnidarian Venoms / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006614:Hindlimb / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012615:Sea Anemones / Q000737:chemistry*
chemical_list: D000700:Analgesics; D003064:Cnidarian Venoms; D009292:Narcotic Antagonists; D011985:Receptors, Serotonin; C558251:bunodosine 391; D009270:Naloxone