title: Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma.
abstract: Melanoma prognosis is based on specific pathological features at the primary lesion. In metastatic patients, the extent of lymph node involvement is also an important prognosis indicator. Many progression markers both in tissues and serum, including circulating tumor cells, have been studied and new molecular markers are awaited from high-throughput screenings to discriminate between clinical stages and predict disease progression. The present review focuses on human tyrosinase related protein 1 also known as gp75 glycoprotein (Tyrp1/gp75), a melanosomal protein involved in the pigmentary machinery of the melanocyte and often used as differentiation marker, with a special emphasis on its emerging roles in the malignant melanocyte and melanoma progression.
authors.affiliation: LOCE, Institut J Bordet, Université Libre de Bruxelles, Rue Héger-Bordet 1, B-1000 Brussels, Belgium. gghanem@ulb.ac.be
authors.forename: Ghanem
authors.initials: G
authors.lastname: Ghanem
authors.forename: Journé
authors.initials: J
authors.lastname: Fabrice
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D008545:Melanoma / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D010088:Oxidoreductases / Q000032:analysis / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000628:therapy
chemical_list: D000906:Antibodies; D010088:Oxidoreductases; C064056:tyrosinase-related protein-1