title: The water delivery system affects the rate of weight gain in C57BL/6J mice during the first week after weaning.
abstract: Facility planners, IACUCs, veterinary staff, and researchers make choices on water delivery systems for rodents on the basis of cost effectiveness, water quality, risk of malfunction, and potential effect on animal health and welfare. Here we compare biometrics, including weight trends, of newly arrived mice unfamiliar with automated watering; weight trends of weanlings; fecundity of mice; and risk of malfunction among 3 water delivery techniques: water bottle only, combination of automated delivery and water bottle, and automated system only. There was no statistically significant difference among the 3 experimental groups with respect to fecundity, mortality, and delivery malfunction. On the basis of body weight trends, the health and wellbeing of the mice used in these studies were not affected by the water delivery system or housing density after the first week; however, there was a significant difference in the growth rate at 21 to 28 d of age among the 3 groups of pups. The mice receiving both automated delivery and water bottles experienced higher growth rates from 21 to 28 d of age than did the other experimental groups. However, after 35 d of age, weight trends did not differ among the groups. Our results suggest that mice weaned into the same method of water delivery as their respective dams thrive equally well among the 3 tested water delivery systems.
authors.affiliation: Department of Comparative Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. alexander1_gordon@urmc.rochester.edu
authors.forename: Alexander
authors.initials: A
authors.lastname: Gordon
authors.forename: Jeff
authors.initials: J
authors.lastname: Wyatt
mesh_terms: D000818:Animals; D004327:Drinking Behavior; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006799:Housing, Animal; D007756:Laboratory Animal Science / Q000379:methods*; D008098:Litter Size; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000254:growth & development*; D012737:Sex Factors; D014867:Water; D014886:Weaning; D015430:Weight Gain
chemical_list: D014867:Water