title: Increased bone turnover markers after renal transplantation.
abstract: Bone remodeling is a process that occurs continuously in a seemingly inactive tissue like bone. Because of decreased vitamin D synthesis, phosphorus retention and decreased calcium blood concentration, patients with chronic renal failure (CRF) develop secondary hyperparathyroidism. Elevated PTH levels shifts balance between osteoblast and osteoclast activity in favor of osteoclast activity and, therefore, bone resorption. Bone metabolic disorder that affects patients with CRF is called renal osteodystrophy (ROD). We presume that renal transplantation reverses bone metabolism disorder and our goal was to establish whether osteoblast and osteoclast activity returns to the levels of healthy individuals.
authors.affiliation: Department of Urology, University Hospital of Rijeka, Rijeka, Croatia. tonigrsko@yahoo.com
authors.forename: Antun
authors.initials: A
authors.lastname: Grsković
authors.forename: Tanja
authors.initials: T
authors.lastname: Celić
authors.forename: Dora
authors.initials: D
authors.lastname: Fuckar
authors.forename: Dean
authors.initials: D
authors.lastname: Markić
authors.forename: Marin
authors.initials: M
authors.lastname: Troselj
authors.forename: Dragica
authors.initials: D
authors.lastname: Bobinac
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D016723:Bone Remodeling / Q000502:physiology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology
chemical_list: D015415:Biomarkers