title: WSTF does it all: a multifunctional protein in transcription, repair, and replication.
abstract: Williams syndrome transcription factor (WSTF) has emerged as an incredibly versatile nuclear protein. WSTF and the ATP-dependent chromatin remodeling complexes in which it exists, WINAC, WICH, and B-WICH, have been studied in a variety of organisms. This research has revealed roles for WSTF in a number of diverse molecular events. WSTF function includes chromatin assembly, RNA polymerase I and III gene regulation, vitamin D metabolism, and DNA repair. In addition to functioning as a subunit of several ATP-dependent chromatin remodeling complexes, WSTF binds specifically to acetylated histones and is itself a histone kinase as well as a target of phosphorylation. This review will describe the three known WSTF-containing complexes and discuss their various roles as well as mechanisms of regulating WSTF activity.
authors.affiliation: Department of Biological Sciences, University of Alaska Anchorage, 3211 Providence Drive, Anchorage, AK 99508, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Barnett
authors.forename: Jocelyn E
authors.initials: JE
authors.lastname: Krebs
mesh_terms: D000255:Adenosine Triphosphate / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics; D010766:Phosphorylation / Q000235:genetics; D011485:Protein Binding / Q000235:genetics; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics*; D030181:Vitamin D Response Element / Q000235:genetics; D018980:Williams Syndrome / Q000235:genetics*; D000092468:Bromodomain Containing Proteins
chemical_list: D000255:Adenosine Triphosphate; D009687:Nuclear Proteins; D014157:Transcription Factors; C116750:BAZ1B protein, human; D000092468:Bromodomain Containing Proteins