title: Copper-catalyzed oxidative cross-coupling of N,N-dimethylanilines with heteroarenes under molecular oxygen.
abstract: Nitrogen-containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparation. In this paper, we report a direct cross-coupling reaction of heteroarenes with N,N-dimethylanilines in the presence of copper catalyst. Oxygen and/or air are successfully used as the oxidant, which is of great importance to the industrialized economies. The reaction is compatible with a wide range of heterocycles, including indolizines, imidazoles, indoles, and aniline, to enable the formation of various alkylated heteroarenes under very mild reaction conditions.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
authors.forename: Lehao
authors.initials: L
authors.lastname: Huang
authors.forename: Tianmin
authors.initials: T
authors.lastname: Niu
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Zhang