title: Glabridin from Chinese herb licorice inhibits fatigue in mice.
abstract: The inhibiting effect of glabridin from Chinese herb Licorice on fatigue was investigated in male BALB/c mice. Mice were divided into the following 4 experimental groups: control group (CG), low dose group (LG), middle dose group (MG) and high dose group (HG,). The control group was given 0.5% Tween 80 solution and the treatment groups (LG, MG, HG) were given various doses of glabridin (5, 10, 20 mg/kg) for 28 consecutive days. Body mass, blood lactic acid (BLA), serum blood urea nitrogen (BUN), liver glycogen and muscle glycogen concentrations in mice were determined. Results showed that glabridin significantly inhibited fatigue, which extended the exhaustive exercise time of mice, effectively delayed the elevation of blood lactic acid and increase in the storage of liver and muscle glycogen.
authors.affiliation: East China Jiaotong University, Nanchang City, Jiangxi Province, 330013, PR China. huapingshang@163.com
authors.forename: Huaping
authors.initials: H
authors.lastname: Shang
authors.forename: Shehua
authors.initials: S
authors.lastname: Cao
authors.forename: Jihui
authors.initials: J
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Zheng
authors.forename: Ramesh
authors.initials: R
authors.lastname: Putheti
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002681:China; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D007529:Isoflavones / Q000494:pharmacology*; D019344:Lactic Acid / Q000097:blood; D008112:Liver Glycogen / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018763:Muscle Fatigue / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D010807:Physical Endurance / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D013550:Swimming / Q000502:physiology
chemical_list: D004791:Enzyme Inhibitors; D007529:Isoflavones; D008112:Liver Glycogen; D010636:Phenols; D010936:Plant Extracts; D019344:Lactic Acid; C107601:glabridin