title: Isolation and structure elucidation of izuminosides A-C: a rare phenazine glycosides from Streptomyces sp. IFM 11260.
abstract: Three new glycosylated phenazine derivatives, named izuminosides A-C (1-3) have been isolated from the ethyl acetate extract of Streptomyces sp. IFM 11260. The structures of the new compounds were determined on the basis of their spectral data. Compounds 1-3 were evaluated for their activity in overcoming tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in human gastric adenocarcinoma cells. Compounds 2 (10  μM) and 3 (60  μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance AGS cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Abdelfattah
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Toume
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D045744:Cell Line, Tumor / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D006027:Glycosides; D010619:Phenazines; C558374:izuminoside A; C558375:izuminoside B; C558376:izuminoside C