title: Primary intracerebral Hodgkin lymphoma with recurrence.
abstract: OBJECTIVE
  To report a case of primary intracerebral Hodgkin lymphoma with disease recurrence.
  
  
  METHODS
  Case report and review of the literature.
  
  
  RESULTS
  A 58-year-old immunocompetent male presented with aphasia. Neuroimaging revealed a left temporal lobe lesion. A craniotomy and resection were performed, and the diagnosis of classical Hodgkin lymphoma was made. Systemic work-up for lymphoma was negative. Postoperatively, the patient was treated with whole brain irradiation. 14 months later, the patient developed an enhancing lesion in his pons and received combination chemotherapy and radiation therapy. Repeat imaging demonstrated leptomeningeal enhancement and multiple lesions throughout the cerebral hemispheres, cerebellum and brainstem.
  
  
  CONCLUSIONS
  We report what appears to be the first case of a patient with aggressive primary intracerebral Hodgkin lymphoma with disease recurrence.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. foo00001@mc.duke.edu
authors.forename: W-C
authors.initials: WC
authors.lastname: Foo
authors.forename: A
authors.initials: A
authors.lastname: Desjardins
authors.forename: T J
authors.initials: TJ
authors.lastname: Cummings
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D016371:Cranial Irradiation; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D019635:Neurosurgical Procedures