title: Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.
abstract: Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.
authors.affiliation: Department of Radiology, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL 60611-2927, USA. ann-ragin@northwestern.edu
authors.forename: Ann B
authors.initials: AB
authors.lastname: Ragin
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Renee
authors.initials: R
authors.lastname: Ochs
authors.forename: Hongyan
authors.initials: H
authors.lastname: Du
authors.forename: Leon G
authors.initials: LG
authors.lastname: Epstein
authors.forename: Katherine
authors.initials: K
authors.lastname: Conant
authors.forename: Justin C
authors.initials: JC
authors.lastname: McArthur
mesh_terms: D015526:AIDS Dementia Complex / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D000465:Algorithms; D001284:Atrophy; D057205:Automation, Laboratory; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D002452:Cell Count; D003071:Cognition; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D005260:Female; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000378:metabolism / Q000473:pathology / Q000821:virology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D020783:Matrix Metalloproteinase 7 / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D008875:Middle Aged; D019562:Viral Load
chemical_list: D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2