title: [Effects of different intraabdominal pressure of carbon dioxide pneumoperitoneum on hemorrheology and microcirculation in rabbits].
abstract: OBJECTIVE
  To study effects of different intraabdominal pressure of carbon dioxide (Cq2) pneumoperitoneum on hemorrheology and microcirculation in rabbits.
  
  
  METHODS
  Eighteen female healthy rabbits weighing 2.2 kg to 3.5 kg were randomly divided into three groups equally based on pneumoperitoneum pressure: 0 mmHg group (group I),10 mmHg group (group II) and 15 mmHg (group III). Each group received 1 h pneumoperitoneum under different pressure. Blood samples were taken at 5 min before CO2 pneumoperitoneum, at 30 and 60 min after pneumoperitoneum for the measurements of indexes of hemorrheology. Hemodynamics including heart rate (HR), mean arterial pressure (MAP) and the volume and velocity of the microcirculation of auricle were continuously monitored, such indexes were recorded at the related time.
  
  
  RESULTS
  Afer pneumoperitoneum at 30 and 60 min, compared with group I, HR, MAP, the whole blood viscosity, the aggregation and rigid indexes of RBC were significantly raised in group II (P < 0.05), the deformability indexes of RBC, the volume and velocity of the microcirculation were markedly decreased (P < 0.05). Even more significant changes were observed in group III (P < 0.01). The plasma viscosity and the hematocrit changed little.
  
  
  CONCLUSIONS
  After CO2 pneumoperitoneum, hemorrheology is decreased; Although HR, MAP are raised, the volume and velocity of the microcirculation are decreased.
authors.affiliation: Department of Anesthesiology, General Hospital of Chengdu Military Command, Chengdu 610083, China. yezhanyong0710@163.com
authors.forename: Zhan-Yong
authors.initials: ZY
authors.lastname: Ye
authors.forename: He-Nian
authors.initials: HN
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Gui-Sen
authors.initials: GS
authors.lastname: Xu
authors.forename: Ying-Hai
authors.initials: YH
authors.lastname: Liu
authors.forename: Jing-Li
authors.initials: JL
authors.lastname: Hou
mesh_terms: D000005:Abdomen / Q000098:blood supply; D000818:Animals; D001809:Blood Viscosity; D002245:Carbon Dioxide; D005260:Female; D006400:Hematocrit; D018056:Hemorheology; D008833:Microcirculation; D011028:Pneumoperitoneum, Artificial / Q000379:methods*; D011312:Pressure; D011817:Rabbits
chemical_list: D002245:Carbon Dioxide