title: [Future perspective in the treatment of urolithiasis based on oxalate metabolism].
abstract: Urinary excretion of oxalate is one of risk factors in urinary stone formation. Prevention of undesirable overflow into the production of oxalate definitely leads to a decrease of urolithiasis. The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production. On the other hand, urolithiasis is tightly related to lifestyle disease, such as diabetes mellitus and insulin resistance. The hypothesis that insulin resistance induces mitochondria dysfunction, resulting in the decrease of mitochondria-related enzyme activity is a very attractive new treatment strategy of urolithiasis. Namely, the improvement of insulin resistance might prevent stone formation.
authors.affiliation: The Department of Urology, Hamamatsu University School of Medicine.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takayama
authors.forename: Masao
authors.initials: M
authors.lastname: Nagata
authors.forename: Soichi
authors.initials: S
authors.lastname: Mugiya
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Ozono
mesh_terms: D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008019:Life Style; D010070:Oxalates / Q000378:metabolism*; D052878:Urolithiasis / Q000517:prevention & control / Q000628:therapy*
chemical_list: D010070:Oxalates