title: Immediate effect on overactive bladder symptoms following administration of imidafenacin.
abstract: BACKGROUND
  One of the factors influencing the treatment compliance of patients with overactive bladder (OAB) symptoms is thought to be the time to reach clinical effectiveness after administering drugs. We investigated the immediate effect of imidafenacin on OAB symptoms.
  
  
  METHODS
  Imidafenacin (0.1 mg) was administered. OAB symptom scores (OABSS) were evaluated before administration, and at 2 and 4 weeks after administration. The subjective efficacy in patients was examined by recording daily changes for 2 weeks.
  
  
  RESULTS
  Twenty patients were evaluated for efficacy using OABSS and uroflowmetry with postvoid residual volume. Nineteen patients completely recorded daily changes in subjective efficacy. The mean total OABSS decreased gradually during 2 weeks after administration. Patients reported the drug's efficacy to begin 3 days after the commencement of administration. Urinary flow and postvoid residual volume did not change after administration.
  
  
  CONCLUSIONS
  The subjective efficacy of imidafenacin was observed from 3 days after the commencement of administration.
authors.affiliation: Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Kanazawa, Ichikawa, Japan. yasukita@med.kanazawa-u.ac.jp
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Masato
authors.initials: M
authors.lastname: Kuribayashi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Narimoto
authors.forename: Shohei
authors.initials: S
authors.lastname: Kawaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yaegashi
authors.forename: Mikio
authors.initials: M
authors.lastname: Namiki
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012212:Rheology / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D018680:Cholinergic Antagonists; D007093:Imidazoles; C120953:imidafenacin