title: Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation.
abstract: OBJECTIVE
  Little is known about the effects of professional oral health care (POHC) on the outcome of hematopoietic stem cell transplantation (HSCT). We evaluated the effects of POHC given by dentists and dental hygienists on the development of oral mucositis and febrile neutropenia (FN) after allogeneic bone marrow transplantation (BMT).
  
  
  METHODS
  We retrospectively studied 140 adult patients who had received allogeneic BMT, with or without POHC, in our hospital consecutively between February 2002 and December 2009. Oral mucositis was evaluated according to the World Health Organization scale.
  
  
  RESULTS
  The incidence of oral mucositis was 66.7% (52/78) in the patients who had received POHC, compared to 93.5% (58/62) in the non-POHC group (P < 0.001). The incidence of FN and the maximal level of CRP were also significantly lower in the POHC group. Multivariate analysis revealed that the POHC was significantly associated with the incidence of oral mucositis (odds ratio, 7.58; 95%CI, 2.45-23.34; P < 0.001).
  
  
  CONCLUSIONS
  We concluded that POHC reduced the incidences of oral mucositis and FN by upgrading the overall oral hygiene during HSCT.
authors.affiliation: Gerodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Kita-13 Nishi-7, Kita-ku, Sapporo 060-8586, Japan. kashi@den.hokudai.ac.jp
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kashiwazaki
authors.forename: Takae
authors.initials: T
authors.lastname: Matsushita
authors.forename: Junichi
authors.initials: J
authors.lastname: Sugita
authors.forename: Akio
authors.initials: A
authors.lastname: Shigematsu
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kasashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanehira
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Endo
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashino
authors.forename: Mitsufumi
authors.initials: M
authors.lastname: Nishio
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Inoue
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation / Q000379:methods; D003695:Delivery of Health Care; D003729:Dental Care / Q000379:methods*; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms / Q000628:therapy; D009503:Neutropenia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D009909:Oral Health; D012189:Retrospective Studies; D013280:Stomatitis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D014184:Transplantation, Homologous; D055815:Young Adult