title: Use of autologous platelet-rich clots for the prevention of local injury bleeding in patients with severe inherited mucocutaneous bleeding disorders.
abstract: Stopping or preventing local bleeding in patients with inherited bleeding disorders linked to abnormal platelet function is traditionally treated by transfusion of blood cell products or recombinant factor VIIa. We now report the use in such patients of autologous platelet-rich clots as an aid to preventing bleeding and to facilitating tissue regeneration at superficial sites. Two patients with von Willebrand's disease (VWD) type 2B and one patient with type I Glanzmann thrombasthenia were treated after tooth extraction and dental surgery. A fourth patient with platelet-type VWD underwent a skin biopsy. Whereas all four patients had a lifelong history of bleeding complications, the application of an autologous platelet-rich clot immediately after surgery combined with tranexamic acid intake to slow fibrinolysis prevented blood loss and resulted in rapid and normal healing. This new procedure is simple, safe and inexpensive; it provides extra security for patients with a bleeding risk undergoing dentistry or superficial surgery.
authors.affiliation: Centre de Référence des Pathologies Plaquettaires, Hôpital Xavier Arnozan, Pessac, France. paquita.nurden@cnrshl.u-bordeaux2.fr
authors.forename: P
authors.initials: P
authors.lastname: Nurden
authors.forename: I
authors.initials: I
authors.lastname: Youlouz-Marfak
authors.forename: F
authors.initials: F
authors.lastname: Siberchicot
authors.forename: E
authors.initials: E
authors.lastname: Kostrzewa
authors.forename: I
authors.initials: I
authors.lastname: Andia
authors.forename: E
authors.initials: E
authors.lastname: Anitua
authors.forename: A T
authors.initials: AT
authors.lastname: Nurden
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D013915:Thrombasthenia / Q000601:surgery / Q000628:therapy*; D014182:Transplantation, Autologous; D056725:von Willebrand Disease, Type 1 / Q000601:surgery / Q000628:therapy*; D056728:von Willebrand Disease, Type 2 / Q000601:surgery / Q000628:therapy*