title: Peripheral neuropathy is associated with increased serum levels of uric acid in type 2 diabetes mellitus.
abstract: We assessed serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM) with or without peripheral neuropathy (diagnosed by the Neuropathy Disability score [NDS]). We enrolled 64 patients with T2DM with peripheral neuropathy (group A: 31 men, mean age 63.0 ± 2.8 years) and 66 age-, gender-, renal function- and T2DM duration-matched patients without neuropathy (group B: 32 men, mean age 62.4 ± 3.1 years). Serum uric acid was significantly higher in group A (P < .001). There was a significant correlation between SUA and NDS in both groups (group A: r(s) = .93, P < .001; group B: r( s) = .95, P < .001). C-reactive protein (CRP) was also significantly higher in group A (P < .001) and correlated significantly with SUA in both groups (group A: r(s) = .93, P < .001; group B: r(s) = .87, P < .001). Serum uric acid is increased in patients with T2DM with neuropathy versus those without. Whether SUA is involved in the pathogenesis of T2DM peripheral neuropathy remains to be established.
authors.affiliation: Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece. papanasnikos@yahoo.gr.
authors.forename: N
authors.initials: N
authors.lastname: Papanas
authors.forename: N
authors.initials: N
authors.lastname: Katsiki
authors.forename: K
authors.initials: K
authors.lastname: Papatheodorou
authors.forename: M
authors.initials: M
authors.lastname: Demetriou
authors.forename: D
authors.initials: D
authors.lastname: Papazoglou
authors.forename: T
authors.initials: T
authors.lastname: Gioka
authors.forename: E
authors.initials: E
authors.lastname: Maltezos
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003929:Diabetic Neuropathies / Q000097:blood*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D002097:C-Reactive Protein