title: Odontogenic fibroma: a clinicopathological study of 15 cases.
abstract: OBJECTIVE
  Odontogenic fibroma (ODF) is a rare odontogenic tumor. It can be further divided into peripheral odontogenic fibroma (PODF) and central odontogenic fibroma (CODF). This retrospective study evaluated the clinical and histopathological features of 15 ODFs in Taiwanese patients.
  
  
  METHODS
  Fifteen consecutive cases of ODF were collected from 1984 to 2009. The clinical data and microscopic features of these cases were reviewed and analyzed.
  
  
  RESULTS
  Twelve PODFs were excised from six male and six female patients (mean age: 35 years) and three CODFs from two male and one female patients (mean age: 11 years). Eight of the 12 PODFs were found on the mandibular gingiva and four on the maxillary gingiva, with the most common site being the mandibular anterior and premolar region (5 cases). Two CODFs were located in the molar region of the mandible and one in the anterior maxilla. Two CODFs showed a mixed lesion and one a radiolucent lesion. No recurrence of the 15 ODFs was found after total excision or enucleation. Microscopically 58.3% of the PODFs showed surface ulcèration. Calcified foci composed of osteoid, cementoid, or cementicle-like materials were noted in all 15 ODFs. Nests or strands of odontogenic epithelium were found in all 15 ODFs. The stromal component was mainly fibro-collagenous in nine of the 12 PODFs, whereas two of the three CODFs contained predominantly myxomatous stroma.
  
  
  CONCLUSIONS
  PODFs occurred more commonly than CODFs. PODF showed an equal sex distribution and was found more frequently in patients in the third to fourth decades of life. The most commonly affected site was the mandibular gingiva, especially the anterior and premolar gingiva. Only three CODFs were found; therefore, we could not draw any conclusions about CODF in Taiwanese patients.
authors.affiliation: Graduate Institute of Clinical Dentistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Hung-Pin
authors.initials: HP
authors.lastname: Lin
authors.forename: Hsin-Ming
authors.initials: HM
authors.lastname: Chen
authors.forename: Chuan-Hang
authors.initials: CH
authors.lastname: Vu
authors.forename: Hsiang
authors.initials: H
authors.lastname: Yang
authors.forename: Ru-Cheng
authors.initials: RC
authors.lastname: Kuo
authors.forename: Ying-Shiung
authors.initials: YS
authors.lastname: Kuo
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005350:Fibroma / Q000473:pathology* / Q000601:surgery; D005887:Gingival Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000473:pathology* / Q000601:surgery; D015995:Prevalence; D012189:Retrospective Studies; D017678:Sex Distribution; D013624:Taiwan; D016896:Treatment Outcome; D055815:Young Adult