title: Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis.
abstract: BACKGROUND
  A major challenge in clinical periodontics is to find a reliable molecular marker of periodontal tissue destruction with high sensitivity, specificity and utility.
  
  
  OBJECTIVE
  The aim of this systematic review is to evaluate available literature on 'the utility of molecular markers of soft and hard periodontal tissue destruction'.
  
  
  METHODS
  Based on the focused question, 'What is the utility of molecular markers of soft and hard periodontal tissue destruction', an electronic and manual search was conducted for human studies presenting clinical data for the potential of molecular markers of tissue destruction in biofluids; gingival crevicular fluid (GCF), saliva, and serum.
  
  
  RESULTS
  Papers fulfilling the inclusion criteria were selected. All relevant data from the selected papers were extracted and recorded in separate tables for molecules in GCF, saliva, and serum.
  
  
  CONCLUSIONS
  Within the defined limits of the Problem/Population, Intervention, Comparison, Outcome, the present analysis reveals that (a) no single or combination of markers exists that can disclose periodontal tissue destruction adequately; (b) while the most fruitful source of biomarkers for periodontal destruction appears to be in molecules tightly related to bone and soft tissue destruction, this remains to be objectively demonstrated. Currently, clinical measurements are still the most reliable.
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey. nurcan.buduneli@ege.edu.tr
authors.forename: Nurcan
authors.initials: N
authors.lastname: Buduneli
authors.forename: Denis F
authors.initials: DF
authors.lastname: Kinane
mesh_terms: D016301:Alveolar Bone Loss / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D005891:Gingivitis / Q000097:blood / Q000175:diagnosis; D006801:Humans; D017622:Periodontal Attachment Loss / Q000097:blood / Q000175:diagnosis; D010514:Periodontal Pocket / Q000097:blood / Q000175:diagnosis; D010518:Periodontitis / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012463:Saliva / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers