title: Impact of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio on long-term outcome in patients undergoing percutaneous coronary intervention.
abstract: BACKGROUND
  Several studies have demonstrated that the low-density lipoprotein cholesterol/high-denisty lipoprotein-cholesterol (LDL-C/HDL-C) ratio is an excellent predictor of cardiovascular disease. The aim of the present study was to determine whether the LDL-C/HDL-C ratio would affect outcome in patients after percutaneous coronary intervention (PCI).
  
  
  RESULTS
  Six-hundred-eighty-seven participants who underwent successful PCI for acute coronary syndromes or stable angina were enrolled. They were divided into 3 groups on the basis of the LDL-C/HDL-C ratio recorded 6 months after PCI: those with LDL-C/HDL-C≤1.5 (n=125); 1.5<LDL-C/HDL-C≤2.0 (n=205); LDL-C/HDL-C>2 (n=357). In the 3 groups, the incidence of major adverse cardiac events (MACE) was measured during the 5 years after baseline evaluation. MACE was defined as cardiac death, non-fatal myocardial infarction, new lesions, and restenosis. The median follow-up duration was 33 months. Kaplan-Meier analysis demonstrated that patients with LDL-C/HDL-C≤1.5 had a significantly lower incidence of MACE after PCI than patients with 1.5<LDL-C/HDL-C≤2.0 (P=0.014) or with LDL-C/HDL-C>2.0 (P<0.001). In addition, Cox proportional hazards analysis indicated that the LDL-C/HDL-C ratio was correlated with the incidence of MACE (HR=1.39, 95% confidence interval: 1.20-1.61, P<0.001).
  
  
  CONCLUSIONS
  The LDL-C/HDL-C ratio had an impact on long-term outcome in patients undergoing PCI.
authors.affiliation: Cardiovascular Center, KKR Takamatsu Hospital, 4-18 Tenjinmae, Takamatsu 760-0018, Japan. ichiroh@kkr-ta-hp.gr.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Miyake
authors.forename: Mizuki
authors.initials: M
authors.lastname: Mizukawa
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Takagi
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000401:mortality / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000097:blood / Q000401:mortality / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL