title: Phytochemical potential of Eruca sativa for inhibition of melanoma tumor growth.
abstract: Solvent extracts from the aerial and root parts and seed oil from E. sativa (rocket salad) were assayed for anticancer activity against melanoma cells. The seed oil (isothiocyanates rich) significantly (p<0.01) reduced the tumor growth comparable to the control. Remarkably, the seed oil inhibited melanoma growth and angiogenesis in mice without any major toxicity. The findings qualify seed oil for further investigations in the real of cancer prevention and treatment.
authors.affiliation: Department of Chemistry, Dayalbagh Educational Institute, Agra 282110, India.
authors.forename: M
authors.initials: M
authors.lastname: Khoobchandani
authors.forename: N
authors.initials: N
authors.lastname: Ganesh
authors.forename: S
authors.initials: S
authors.lastname: Gabbanini
authors.forename: L
authors.initials: L
authors.lastname: Valgimigli
authors.forename: M M
authors.initials: MM
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000627:therapeutic use; D019607:Brassicaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017879:Isothiocyanates / Q000032:analysis; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D010636:Phenols / Q000032:analysis; D010840:Phytosterols / Q000032:analysis; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017879:Isothiocyanates; D010636:Phenols; D010840:Phytosterols; D010938:Plant Oils