title: Protective effects of erdosteine on amikacin induced visual evoked potentials and lipid peroxidation alterations.
abstract: OBJECTIVE
  We aimed at investigating the effect of erdosteine administration on amikacin induced visual evoked potentials (VEPs) alterations in rats.
  
  
  METHODS
  For this purpose, forty male Wistar rats were divided into 4 groups: control, amikacin treated, erdosteine treated, and amikacin + erdosteine treated. Amikacin (600 mg/kg/day) was applied as a single dose of intramuscular injection for 14 days, and 10 mg/kg/day erdosteine was given by gastric gavage for the same period. We recorded all VEP components and measured plasma thiobarbituric acid reactive substance (TBARS) levels in all groups.
  
  
  RESULTS
  Amikacin increased the latencies of all VEP components (P1, N1, P2, N2, and P3) and elevated plasma TBARS levels compared with control and erdosteine treated rats (p < 0,01). However, prolonged latencies of VEP components in amikacin treated rats returned to control levels after erdostein administration. Treatment of amikacin and erdosteine together significantly decreased plasma TBARS levels (0.05 ± 0.018 nmol/g protein) compared with amikacin group (0.12 ± 0.038 nmol/g protein).
  
  
  CONCLUSIONS
  These results show that erdosteine has a protective effect on amikacin induced changes in the visual system.
authors.affiliation: Department of Biophysics, Medical School, Akdeniz University, Antalya, Turkey. narinderin@akdeniz.edu.tr
authors.forename: Narin
authors.initials: N
authors.lastname: Derin
authors.forename: Deniz
authors.initials: D
authors.lastname: Akpınar
authors.forename: Filiz
authors.initials: F
authors.lastname: Ozcan
authors.forename: Piraye
authors.initials: P
authors.lastname: Yargıçoğlu
authors.forename: Mutay
authors.initials: M
authors.lastname: Aslan
mesh_terms: D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D058449:Intravitreal Injections; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013864:Thioglycolates / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D017392:Thiobarbituric Acid Reactive Substances; D013864:Thioglycolates; D013876:Thiophenes; C048498:erdosteine; D000583:Amikacin