title: Finite element modelling of the canine and feline outer ear canal: benefits for local drug delivery?
abstract: Current therapeutic regimes of outer ear infections in dogs and cats aim at the application of efficient local therapeutics after cleaning of the acoustic meatus. One so far insufficiently answered question is if the local application of these substances results in an individually suitable drug concentration in the external ear canal. Thus, the purpose of the present study was to develop a finite element model to calculate the values of the different areas of the external acoustic meatus in dogs and cats in order to provide a tool for the benefit of an appropriate local drug dosage determination. A 3D finite element model (FEM), based on computer tomographic (CT) data sets of four dogs and two cats, was generated to determine areas and volumes of the outer ear canal. Furthermore, various ear therapeutics and cleansers were tested concerning their optimal distribution on 5 cm2 dog and cat skin. The data shows major variations of the area values of the external auditory canal in case of the different dogs but not in the examined cats. These results suggest that manufacturer's recommendations of the pharmaceuticals might be insufficient in terms of achieving an optimal drug concentration in the outer ear canal especially in larger dogs. In conclusion, the developed finite element model has shown to be suitable to calculate areas of the outer ear canal in cats and dogs and could be of help in context with the definition of optimal drug concentrations for a local drug delivery.
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Wefstaedt
authors.forename: Bernd-Arno
authors.initials: BA
authors.lastname: Behrens
authors.forename: Ingo
authors.initials: I
authors.lastname: Nolte
authors.forename: Anas
authors.initials: A
authors.lastname: Bouguecha
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002102:Cadaver; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats / Q000033:anatomy & histology*; D003198:Computer Simulation; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs / Q000033:anatomy & histology*; D004424:Ear Canal / Q000033:anatomy & histology*; D008953:Models, Anatomic; D010032:Otitis Externa / Q000188:drug therapy / Q000662:veterinary*