title: Stage-by-stage effects of surgical margin status on biochemical failure after radical prostatectomy in patients with clinically localized prostate cancer.
abstract: OBJECTIVE
  To evaluate the effects of pathological stage and surgical margin status on biochemical failure rates after radical prostatectomy (RP).
  
  
  METHODS
  The records of 205 patients who underwent RP for clinically localized prostate cancer (CaP) were evaluated. Known risk factors for biochemical failure (BF) were analyzed using univariate and multivariate logistic regression analysis. The effects of surgical margin status together with pathological stage on BF were evaluated. p values lower than 0.05 were accepted to be statistically significant.
  
  
  RESULTS
  Pathological stage, positive surgical margin (PSM), seminal vesicle invasion, lymph node involvement, biopsy Gleason score and postoperative Gleason score were the factors associated with BF in univariate analysis. Logistic regression analysis revealed that pT3a patients with PSM had a significant BF rate when compared to pT2 patients with a negative surgical margin (NSM) (OR 7.46, p = 0.002). pT3a patients with a NSM had a similar BF rate to that of pT2 patients with PSM.
  
  
  CONCLUSIONS
  pT2 patients with PSM had a similar biochemical prognosis to that of pT3a patients without PSM, implicating that a PSM may have a negative effect on prognosis similar to that of extracapsular invasion.
authors.affiliation: Clinic of Urology II, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Alp Ozgur
authors.initials: AO
authors.lastname: Akdemir
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Ozden
authors.forename: Cetin Volkan
authors.initials: CV
authors.lastname: Oztekin
authors.forename: Binhan Kagan
authors.initials: BK
authors.lastname: Aktas
authors.forename: Mesut
authors.initials: M
authors.lastname: Cetinkaya
authors.forename: Ali
authors.initials: A
authors.lastname: Memis
authors.forename: Omer Gokhan
authors.initials: OG
authors.lastname: Doluoglu
mesh_terms: D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000096:biosynthesis; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000601:surgery*; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen