title: CD4+CD25+ regulatory T cell-mediated changes in the expression of endocytic receptors and endocytosis process of human dendritic cells.
abstract: CD4+CD25+ regulatory T cells (Tregs) are known to inhibit immune responses to antigens. Since, the process of antigen uptake by dendritic cells (DC) is central to induction of immune responses, we analyzed the effect of Tregs on the expression of endocytic receptors on DC and its repercussion on antigen uptake. Our results demonstrate that Tregs down-regulate the expression and uptake of antigens via C-type lectin-like receptors CD206 and DC-SIGN, restrain the pinocytosis process of DC and augment the expression of FcγRIIB, an inhibitory Fcγ receptor the engagement of which by IgG-bound antigens leads to inhibition of DC activation. Our results thus provide an additional insight on the pertinence of strategies aimed at blocking Treg functions towards improved vaccination protocols.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 872, Paris F-75006, France.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Navarrete
authors.forename: Sandrine
authors.initials: S
authors.lastname: Delignat
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Teillaud
authors.forename: Srini V
authors.initials: SV
authors.lastname: Kaveri
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000032:analysis; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D004705:Endocytosis; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000032:analysis; D037181:Lectins, C-Type / Q000032:analysis; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis; D017452:Receptors, IgG / Q000032:analysis; D050378:T-Lymphocytes, Regulatory / Q000737:chemistry / Q000276:immunology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D053645:Interleukin-2 Receptor alpha Subunit; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C499173:FCGR2B protein, human; C508017:IL2RA protein, human