title: Cimetidine: an anticancer drug?
abstract: Cimetidine, H(2) receptor antagonists, is commonly prescribed for gastric and duodenal ulcer disease. Additionally, cimetidine has been shown to have anticancer effects. This review describes the mechanism of antitumor action of cimetidine including its ability to interfere with tumor cell adhesion, angiogenesis and proliferation; its effect on the immune system; as well as inhibition of postoperative immunosuppression. Its anticancer effect is also compared to that of the other H(2) receptor antagonists as well as outcomes of cimetidine in clinical studies in cancer patients.
authors.affiliation: Department of Radiotherapy and Oncology, Charles University in Prague, Third Faculty of Medicine and Faculty Hospital Kralovske Vinohrady, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Kubecova
authors.forename: Katarina
authors.initials: K
authors.lastname: Kolostova
authors.forename: Daniela
authors.initials: D
authors.lastname: Pinterova
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kacprzak
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bobek
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D006635:Histamine H2 Antagonists; D002927:Cimetidine