title: Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors.
abstract: Synthesis, and structure-activity relationship (SAR) studies of the novel IKK-β inhibitors 2 and 3 characterized by a dihydrothieno[2,3-e]indazole core are presented. Compound 2t was efficacious in a mouse model of LPS-stimulated TNF-α production.
authors.affiliation: Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd, Shimotsuga-gun, Tochigi, Japan. hiroyasu.takahashi@mb.kyorin-pharm.co.jp
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Mariko
authors.initials: M
authors.lastname: Shinoyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Komine
authors.forename: Muneki
authors.initials: M
authors.lastname: Nagao
authors.forename: Masashi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Tsuchida
authors.forename: Koichi
authors.initials: K
authors.lastname: Katsuyama
mesh_terms: D000818:Animals; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors*; D007191:Indazoles / Q000494:pharmacology*; D051379:Mice; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*
chemical_list: D007191:Indazoles; D047428:Protein Kinase Inhibitors; D051550:I-kappa B Kinase