title: Static magnetic field accelerates aging and development in nematode.
abstract: Electro-magnetic fields are everywhere in our life. The strength and duration of human exposure is proportional to the degree of industrialization. The possible health hazard has been investigated for decades. C. elegans (nematode) has been a sensitive tool to study aging and development. The current study investigated the possible effects of static magnetic fields (SMFs) on the developmental and aging processes of C. elegans. Nematodes were grown in the presence of SMFs of strengths varying from 0 to 200 mT. Treatment with a 200 mT SMF reduced the development times from L2 to young adult by approximately 20%. After SMF treatment, the average lifespan was reduced from 31 days to 25 days for wild-type nematodes. The upregulation of genes associated with development and aging was verified by quantitative real-time RT-PCR. Nematodes carrying mutation in these genes also exhibited resistance to the SMFs treatment. Apparently, induction of gene expression is selective and dose-dependent. SMFs accelerate nematode development and shorten nematode lifespan through pathways associated with let-7, clk-1, unc-3 and age-1.
authors.affiliation: Institute of Nanotechnology; Department of Material Science and Engineering; National Chiao Tung University; Taiwan.
authors.forename: Chia-Hui
authors.initials: CH
authors.lastname: Lee
authors.forename: Yao-Ching
authors.initials: YC
authors.lastname: Hung
authors.forename: G Steven
authors.initials: GS
authors.lastname: Huang