title: Single-dose pharmacokinetics and tolerability of daptomycin 8 to 10 mg/kg in children aged 2 to 6 years with suspected or proved Gram-positive infections.
abstract: A pharmacokinetic analysis was performed for single intravenous doses of daptomycin 8 or 10 mg/kg in subjects aged 2 to 6 years. Proportional increases in maximum plasma concentration (68.4 μg/mL, 79.2 μg/mL) and area under the curve (429.1 μg · h/mL, 549.7 μg · h/mL) were observed for each dose cohort, respectively. Half-life, clearance, and distribution volume were similar between groups. Both doses were well tolerated.
authors.affiliation: Division of Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA. srahman@cmh.edu
authors.forename: Susan M
authors.initials: SM
authors.lastname: Abdel-Rahman
authors.forename: Gurudatt
authors.initials: G
authors.lastname: Chandorkar
authors.forename: Ronda L
authors.initials: RL
authors.lastname: Akins
authors.forename: John S
authors.initials: JS
authors.lastname: Bradley
authors.forename: Richard F
authors.initials: RF
authors.lastname: Jacobs
authors.forename: Julie
authors.initials: J
authors.lastname: Donovan
authors.forename: David P
authors.initials: DP
authors.lastname: Benziger
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D017576:Daptomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D010949:Plasma / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin