title: Systemic lupus erythematosus induced by interferon β1 therapy in a patient with multiple sclerosis.
abstract: Drug-induced lupus erythematosus is defined as a lupus-like syndrome temporally related to a drug exposure. We report a 34-year-old woman with multiple sclerosis who developed, while being treated with interferon β-1a, myalgia and associated with wrist synovitis. Clinical and immunologic investigations were in favor of systemic lupus erythematosus. Interferon therapy was maintained. Under corticosteroids and antipaludeen treatment, the patient did not develop any other lupic manifestations.
authors.affiliation: Rheumatology Department, La Rabta Hospital, 1007 Tunis, Tunisia. mrabetdalila@yahoo.fr
authors.forename: Dalila Mrabet
authors.initials: DM
authors.lastname: Bahri
authors.forename: Hela
authors.initials: H
authors.lastname: Khiari
authors.forename: Asma
authors.initials: A
authors.lastname: Essouri
authors.forename: Lilia
authors.initials: L
authors.lastname: Laadhar
authors.forename: Ines
authors.initials: I
authors.lastname: Zaraa
authors.forename: Amel
authors.initials: A
authors.lastname: Mrabet
authors.forename: Nihel
authors.initials: N
authors.lastname: Meddeb
authors.forename: Slaheddine
authors.initials: S
authors.lastname: Sellami
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000009:adverse effects* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D009103:Multiple Sclerosis / Q000188:drug therapy; D013585:Synovitis / Q000139:chemically induced*; D014955:Wrist Joint / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D005938:Glucocorticoids; D016899:Interferon-beta; D000068556:Interferon beta-1a