title: The immunohistochemical method.
abstract: Immunohistochemistry involves the binding of an antibody to a cellular or tissue antigen of interest and then visualization of the bound product by a detection system. With the ever-increasing number of antibodies against cellular epitopes, immunohistochemistry is an extremely useful diagnostic tool as well as a means to guide specific therapies that target a particular antigen on neoplastic cells. As many antibodies are effective in fixed paraffin-embedded tissues, large retrospective studies of protein expression in a variety of human cancers can easily be performed.
authors.affiliation: Department of Pathology, University of Virginia Health System, Charlottesville, VA.
authors.forename: L A
authors.initials: LA
authors.lastname: Cerilli
authors.forename: H F
authors.initials: HF
authors.lastname: Frierson