title: Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma.
abstract: Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial-mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC.
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. hshiraha@md.okayama-u.ac.jp
authors.forename: Hidenori
authors.initials: H
authors.lastname: Shiraha
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Nishina
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D002453:Cell Cycle; D050677:Core Binding Factor Alpha 3 Subunit / Q000235:genetics* / Q000502:physiology; D019175:DNA Methylation; D015536:Down-Regulation; D058750:Epithelial-Mesenchymal Transition; D052138:Genes, Neoplasm; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D019656:Loss of Heterozygosity; D009389:Neovascularization, Pathologic / Q000378:metabolism; D011401:Promoter Regions, Genetic
chemical_list: D050677:Core Binding Factor Alpha 3 Subunit; C493729:Runx3 protein, human