title: Effects of chlorpyrifos exposure on kidney Notch2-Jagged1 pathway of early prenatal embryo.
abstract: OBJECTIVE
  To evaluate the effects of this insecticide on the embryonic development of kidney and to assess the important role of Notch2-Jagged1 pathway in this duration.
  
  
  RESULTS
  Chlorpyrifos (CPF) 5 mg/kg/d were administrated on gestation 7.5-11.5 day by subcutaneous injection. On gestation 16.5 day, the normal embryo kidney developed through S shape duration to the original kidney, which had the nephrons and could start to secret the urine. But for the CPF-treated mice, the embryo kidney developed much more slowly, they did not show the S shape and the nephrons. The Notch2-Jagged1 pathway should be expressed stronger in the normal embryo kidney on gestation 16.5 day, but for the CPF-treated mice we found the obvious weak pathway staining.
  
  
  CONCLUSIONS
  CPF broke the Notch2-Jagged1 pathway during the embryo kidney development, and the Notch2-Jagged1 pathway plays an important role in the S shape to original kidney formation duration.
authors.affiliation: Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Minmin
authors.initials: M
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Jin
authors.forename: Shi
authors.initials: S
authors.lastname: Feng
authors.forename: Yan
authors.initials: Y
authors.lastname: Bi
authors.forename: Huiping
authors.initials: H
authors.lastname: Wang
authors.forename: Youying
authors.initials: Y
authors.lastname: Mao
authors.forename: Zhangfei
authors.initials: Z
authors.lastname: Shou
authors.forename: Jianghua
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D004390:Chlorpyrifos / Q000633:toxicity*; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D007306:Insecticides / Q000633:toxicity; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D000072100:Jagged-1 Protein; D007668:Kidney / Q000002:abnormalities / Q000187:drug effects / Q000196:embryology*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism*; D051883:Receptor, Notch2 / Q000378:metabolism*; D000072099:Serrate-Jagged Proteins
chemical_list: D002135:Calcium-Binding Proteins; D007306:Insecticides; D036341:Intercellular Signaling Peptides and Proteins; C000606274:Jag1 protein, mouse; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; C497765:Notch2 protein, mouse; D051883:Receptor, Notch2; D000072099:Serrate-Jagged Proteins; D004390:Chlorpyrifos