title: Cyclooxygenase-2 and survivin in superficial urothelial carcinoma of the bladder and correlation with intratumoural microvessel density.
abstract: This study was designed to investigate the protein levels of cyclooxyogenase-2 (COX-2) and survivin in superficial urothelial carcinoma (UC) and their correlation with microvessel density (MVD). High-grade UC was positive for both COX-2 and survivin protein, and the proportion of tumours positive for both proteins increased with increasing tumour grade. The presence of COX-2 protein was significantly correlated with the presence of survivin protein. Both COX-2 and survivin positivity were significantly correlated with MVD in all patients regardless of tumour grade, but there was no correlation between MVD and COX-2 and survivin positivity by individual tumour grade. Although there was no significant difference in the proportion of COX-2-positive tumours when patients were stratified by tumour stage, a significantly higher proportion of patients with pT1 stage tumours were survivin-positive compared with patients with pTa stage tumours. COX-2 and survivin positivity were significantly correlated in all patients regardless of tumour grade or stage. COX-2 and survivin were significantly correlated in patients with pTa, but there was no correlation in pT1 tumours. These findings demonstrate that together, COX-2, survivin and MVD may play an important role in UC.
authors.affiliation: Department of Pathology, Medical Faculty, Duzce University, Duzce, Turkey. umranyildirim@duzce.edu.tr
authors.forename: U
authors.initials: U
authors.lastname: Yildirim
authors.forename: H
authors.initials: H
authors.lastname: Erdem
authors.forename: A
authors.initials: A
authors.lastname: Kayikci
authors.forename: A F
authors.initials: AF
authors.lastname: Sahin
authors.forename: A K
authors.initials: AK
authors.lastname: Uzunlar
authors.forename: A
authors.initials: A
authors.lastname: Albayrak
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D000077022:Survivin; D001749:Urinary Bladder Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human