title: The herbal medicine daikenchuto ameliorates an impaired anorectal motor activity in postoperative pediatric patients with an anorectal malformation--a pilot study.
abstract: Fecoflowmetry (FFM) has been introduced to simulate natural anorectal evacuation. So far, few reports have described the effect of the herbal medicine Daikenchuto (DKT) on impaired anorectal motor function. The aim of this pilot study was to assess anorectal motor function by FFM in postoperatively impaired patients with an anorectal malformation (ARM) before and after administration of DKT. Six postoperative patients with ARM (mean age, 7.8 years) who complained of intractable constipation with soiling in spite of administration of magnesia as a laxative were assessed over an extended period. These patients received 0.3 g/kg/d of DKT for an average of 128 days. Evacuative rate and maximum fecal stream flow were seen to increase significantly after administration of DKT when compared with values before administration of DKT. In conclusion, DKT had a favorable clinical effect on anorectal motor function in postoperative patients with ARM.
authors.affiliation: Department of Pediatric Surgery, Kurume University School of Medicine, Asahimachi, Kurume City, Fukuoka, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Takagi
authors.forename: Minoru
authors.initials: M
authors.lastname: Yagi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Kimio
authors.initials: K
authors.lastname: Asagiri
authors.forename: Takahiro
authors.initials: T
authors.lastname: Asakawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Shinji
authors.initials: S
authors.lastname: Ishii
authors.forename: Hideaki
authors.initials: H
authors.lastname: Egami
authors.forename: Masao
authors.initials: M
authors.lastname: Akaiwa
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tsuru
mesh_terms: D000071056:Anorectal Malformations; D001006:Anus, Imperforate / Q000503:physiopathology / Q000601:surgery; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003248:Constipation / Q000188:drug therapy* / Q000503:physiopathology; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D005894:Panax; D008517:Phytotherapy; D010865:Pilot Projects; D010936:Plant Extracts / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D032106:Zanthoxylum; D030521:Zingiberaceae
chemical_list: D010936:Plant Extracts; C121414:dai-kenchu-to