title: Evaluation of glycemic and lipid profile of offspring of diabetic Wistar rats treated with Malpighia emarginata juice.
abstract: Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.
authors.affiliation: Medical School of Medicine of Marília, Faculty of Technology and Foods of Marília, Avenida Higino Muzzi Filho 1001, Marília, SP, Brazil. smbarbalho@terra.com.br
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Barbalho
authors.forename: Débora C
authors.initials: DC
authors.lastname: Damasceno
authors.forename: Ana Paula Machado
authors.initials: AP
authors.lastname: Spada
authors.forename: Miréia
authors.initials: M
authors.lastname: Palhares
authors.forename: Karla Aparecida
authors.initials: KA
authors.lastname: Martuchi
authors.forename: Marie
authors.initials: M
authors.lastname: Oshiiwa
authors.forename: Viviane
authors.initials: V
authors.lastname: Sazaki
authors.forename: Vanessa Sellis
authors.initials: VS
authors.lastname: da Silva
mesh_terms: D000818:Animals; D001628:Beverages; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology; D005260:Female; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D029581:Malpighiaceae / Q000737:chemistry; D039382:Maternal Nutritional Physiological Phenomena / Q000187:drug effects; D055442:Metabolome / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000473:pathology; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D013311:Streptozocin