title: Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery.
abstract: The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-l-lysine) core with a redox-sensitive disulfide linkage.
authors.affiliation: The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, China.
authors.forename: Hui-Yun
authors.initials: HY
authors.lastname: Wen
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Dong
authors.forename: Wen-juan
authors.initials: WJ
authors.lastname: Xie
authors.forename: Yong-Yong
authors.initials: YY
authors.lastname: Li
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Pauletti
authors.forename: Dong-Lu
authors.initials: DL
authors.lastname: Shi
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004220:Disulfides / Q000737:chemistry*; D004317:Doxorubicin / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry*; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D007700:Kinetics; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D004220:Disulfides; D004337:Drug Carriers; D008823:Micelles; D011107:Polylysine; C038295:poly(N(epsilon)-benzyloxycarbonyl-L-lysine); D011092:Polyethylene Glycols; D004317:Doxorubicin; D005978:Glutathione