title: The ERGonomics of hematopoietic stem cell self-renewal.
abstract: Stem cells make more of themselves by self-renewing cell divisions. In the February 1, 2011, issue of Genes & Development, Taoudi and colleagues (pp. 251-262) show an essential role for the ETS transcription factor ERG in the self-renewal of embryonic hematopoietic stem cells. A model is presented in which the redundant functions of GATA2 and RUNX1 in self-renewal are under direct control of ERG.
authors.affiliation: Division of Hematology/Oncology, Children's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Lacadie
authors.forename: Leonard I
authors.initials: LI
authors.lastname: Zon
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000071230:Transcriptional Regulator ERG
chemical_list: C072312:ERG protein, human; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG