title: Lifestyle changes in women with polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) affects 4% to 18% of reproductive-aged women and is associated with reproductive, metabolic and psychological dysfunction. Obesity worsens the presentation of PCOS and weight management (weight loss, maintenance or prevention of excess weight gain) is proposed as an initial treatment strategy, best achieved through lifestyle changes incorporating diet, exercise and behavioural interventions.
  
  
  OBJECTIVE
  To assess the effectiveness of lifestyle treatment in improving reproductive, anthropometric (weight and body composition), metabolic and quality of life factors in PCOS.
  
  
  METHODS
  Electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), MEDLINE, EMBASE, PsycINFO, CINAHL, AMED), controlled trials register, conference abstracts, relevant journals, reference lists of relevant papers and reviews and grey literature databases, with no language restrictions applied.
  
  
  METHODS
  Randomised controlled trials comparing lifestyle treatment (diet, exercise, behavioural or combined treatments) to minimal or no treatment in women with PCOS.
  
  
  METHODS
  Two authors independently selected trials, assessed methodological quality and risk of bias and extracted data.
  
  
  RESULTS
  Six studies were included. Three studies compared physical activity to minimal dietary and behavioural advice or no advice. Three studies compared combined dietary, exercise and behavioural interventions to minimal intervention. There were no studies assessing fertility primary outcomes and no data for meta-analysis on ovulation or menstrual regularity. For secondary outcomes, lifestyle intervention provided benefits when compared to minimal treatment for endpoint values for total testosterone (mean difference (MD) -0.27 nmol/L, 95% confidence interval (CI) -0.46 to -0.09, P = 0.004), hirsutism by the Ferriman-Gallwey score (MD -1.19, 95% CI -2.35 to -0.03, P = 0.04), weight (MD -3.47 kg, 95% CI -4.94 to -2.00, P < 0.00001), waist circumference (MD -1.95 cm, 95% CI -3.34 to -0.57, P = 0.006), waist to hip ratio (MD -0.04, 95% CI -0.07 to -0.00, P = 0.02), fasting insulin (MD -2.02 µU/mL, 95% CI -3.28 to -0.77, P = 0.002) and oral glucose tolerance test insulin (standardised mean difference -1.32, 95% CI -1.73 to -0.92, P < 0.00001) and per cent weight change (MD -7.00%, 95% CI -10.1 to -3.90, P < 0.00001). There was no evidence of effect of lifestyle for body mass index, free androgen index, sex hormone binding globulin, glucose or lipids; and no data for quality of life, patient satisfaction or acne.
  
  
  CONCLUSIONS
  Lifestyle intervention improves body composition, hyperandrogenism (high male hormones and clinical effects) and insulin resistance in women with PCOS. There was no evidence of effect for lifestyle intervention on improving glucose tolerance or lipid profiles and no literature assessing clinical reproductive outcomes, quality of life and treatment satisfaction.
authors.affiliation: The Jean Hailes Clinical Research Unit, School of Public Health and Preventive Medicine, Monash University, Locked bag 29, Monash Medical Centre, Clayton Road, Clayton Road, Clayton, Victoria, Australia, 3168.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Moran
authors.forename: Samantha K
authors.initials: SK
authors.lastname: Hutchison
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Norman
authors.forename: Helena J
authors.initials: HJ
authors.lastname: Teede
mesh_terms: D050153:Abdominal Fat / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D009765:Obesity / Q000150:complications / Q000628:therapy*; D011085:Polycystic Ovary Syndrome / Q000534:rehabilitation*; D016032:Randomized Controlled Trials as Topic; D014770:Virilism / Q000628:therapy; D015431:Weight Loss