title: Synthesis and antiviral evaluation of new N-acylhydrazones containing glycine residue.
abstract: N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity demonstrated that compound 8c bearing 4-methylphenyl moiety was the most active with low cytotoxicity.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, PO Box 261, Beijing 100191, China.
authors.forename: Baohe
authors.initials: B
authors.lastname: Tian
authors.forename: Meizi
authors.initials: M
authors.lastname: He
authors.forename: Zhiwu
authors.initials: Z
authors.lastname: Tan
authors.forename: Shixing
authors.initials: S
authors.lastname: Tang
authors.forename: Indira
authors.initials: I
authors.lastname: Hewlett
authors.forename: Shuguang
authors.initials: S
authors.lastname: Chen
authors.forename: Yinxue
authors.initials: Y
authors.lastname: Jin
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001665:Binding Sites; D036022:Capsid Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D002460:Cell Line; D003198:Computer Simulation; D005998:Glycine / Q000031:analogs & derivatives*; D015497:HIV-1 / Q000378:metabolism; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: C558494:4-methylbenzaldehyde 2-naphthyloxyacetamidoacetohydrazone; D019380:Anti-HIV Agents; D036022:Capsid Proteins; D006835:Hydrazones; D005998:Glycine