title: Mesoporous bioactive glasses: mechanical reinforcement by means of a biomimetic process.
abstract: Mesoporous bioactive glasses (MBGs) constitute a new family of bioceramics with the fastest in vitro bioactivity studied so far. In this work, pieces with the composition 85SiO(2)-10CaO-5P(2)O(5) (mol.%) were prepared as MBGs and also by the conventional sol-gel method. After in vitro tests in simulated body fluid, the MBG pieces exhibited compression resistance twice as great than before, whereas conventional sol-gel glasses showed similar values. Scanning and transmission electron microscopy demonstrate the development of an apatite-like phase not only on the external surface, but also on the grains located within the MBGs pieces. In contrast, conventional sol-gel glasses only developed an apatite-like phase on the external surface. This work presents for the first time a new property of MBGs: the mechanical reinforcement of a bioactive glass through a biomimetic process. This ability is explained in terms of the outstanding bioactive behavior and the three-dimensional mesoporous structure that is exclusive for this bioceramics family.
authors.affiliation: Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid/Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain. arcosd@farm.ucm.es
authors.forename: D
authors.initials: D
authors.lastname: Arcos
authors.forename: M
authors.initials: M
authors.lastname: Vila
authors.forename: A
authors.initials: A
authors.lastname: López-Noriega
authors.forename: F
authors.initials: F
authors.lastname: Rossignol
authors.forename: E
authors.initials: E
authors.lastname: Champion
authors.forename: F J
authors.initials: FJ
authors.lastname: Oliveira
authors.forename: M
authors.initials: M
authors.lastname: Vallet-Regí
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D032701:Biomimetics; D001826:Body Fluids / Q000737:chemistry; D019245:Compressive Strength; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials