title: Delayed diagnosis of Kawasaki syndrome and thrombosis of a medium-sized aneurysm of the anterior descending coronary artery: case report and literature review.
abstract: A 7-year-old child was first admitted for persistent fever of 15-day duration and suspected meningitis. Kawasaki syndrome was lately diagnosed upon the recognition of an extensive diffuse coronary artery damage characterized by medium-sized aneurysms of the epicardial vessels. An eccentric thrombus along the inferior wall of the left anterior descending artery suspected at transthoracic echocardiography was confirmed by coronary computed tomography angiography scan, without significant segmental stenosis. Strict cardiac surveillance and anticoagulant therapy were maintained, and no ischemic complications occurred at a short-term follow-up. This report emphasizes that thrombosis can be observed even in medium-sized aneurysms when the diagnosis of Kawasaki syndrome is delayed.
authors.affiliation: Section of Pediatric Cardiology, Università Cattolica Sacro Cuore, Largo A. Gemelli, 8, 00168 Rome, Italy. gderosa@rm.unicatt.it
authors.forename: Gabriella
authors.initials: G
authors.lastname: De Rosa
authors.forename: Maria Giuseppina
authors.initials: MG
authors.lastname: Cefalo
authors.forename: Riccardo
authors.initials: R
authors.lastname: Marano
authors.forename: Marco
authors.initials: M
authors.lastname: Piastra
authors.forename: Angelica Bibiana
authors.initials: AB
authors.lastname: Delogu
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D003323:Coronary Aneurysm / Q000175:diagnosis* / Q000188:drug therapy; D017023:Coronary Angiography; D004452:Echocardiography; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D013927:Thrombosis / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D016756:Immunoglobulins, Intravenous