title: Effect of the herbal medicine dai-kenchu-to on gastrointestinal motility in patients with megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) and chronic idiopathic intestinal pseudo-obstruction (CIIP): report of two cases.
abstract: Dai-kenchu-to (DKT), a traditional Japanese herbal medicine (Kampo medicine), composed of zanthoxylum fruit, ginseng root, dried ginger rhizome and malt sugar, is clinically effective for postoperative ileus and chronic constipation. MMIHS and CIIP are severe motility disorder associated with high morbidity. The aim of this study was to evaluate the effect of DKT on functional intestinal obstruction. DKT was clinically effective for gastrointestinal motility in a case with MMIHS, but not effective in one with CIIP. MMIHS and CIIP are speculated to have different pathogenesis regarding gastrointestinal pseudo-obstruction based upon the effect of this drug.
authors.affiliation: Department of Pediatric Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. hhitoshi@is.icc.u-tokai.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hirakawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ueno
authors.forename: Hiromitu
authors.initials: H
authors.lastname: Matuda
authors.forename: Tomoya
authors.initials: T
authors.lastname: Hinoki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kato
mesh_terms: D000015:Abnormalities, Multiple / Q000188:drug therapy / Q000473:pathology; D003106:Colon / Q000002:abnormalities / Q000473:pathology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D040181:Genetic Diseases, X-Linked / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007223:Infant; D007418:Intestinal Pseudo-Obstruction / Q000151:congenital / Q000188:drug therapy / Q000473:pathology; D008518:Medicine, East Asian Traditional; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000002:abnormalities / Q000473:pathology; D055815:Young Adult; D032106:Zanthoxylum; D030521:Zingiberaceae
chemical_list: D010936:Plant Extracts; C121414:dai-kenchu-to