title: Adeno-associated viral vectors for mapping, monitoring, and manipulating neural circuits.
abstract: Understanding the structure and function of neural circuits is central is neuroscience research. To address the associated questions, new genetically encoded tools have been developed for mapping, monitoring, and manipulating neurons. Essential to implementation of these tools is their selective delivery to defined neuronal populations in the brain. This has been facilitated by recent improvements in cell type-specific transgene expression using recombinant adeno-associated viral vectors. Here, we highlight these developments and discuss areas for improvement that could further expand capabilities for neural circuit analysis.
authors.affiliation: Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
authors.forename: J Nicholas
authors.initials: JN
authors.lastname: Betley
authors.forename: Scott M
authors.initials: SM
authors.lastname: Sternson
mesh_terms: D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D000229:Dependovirus; D015870:Gene Expression; D018014:Gene Transfer Techniques; D005819:Genetic Markers; D005822:Genetic Vectors; D006801:Humans; D009474:Neurons / Q000502:physiology*; D011401:Promoter Regions, Genetic; D056189:Viral Tropism / Q000235:genetics
chemical_list: D005819:Genetic Markers