title: Outcome in AN adult patients: a 13-year follow-up in 484 patients.
abstract: BACKGROUND
  To study the long-term prognosis of anorexia nervosa (AN), 484 adult AN patients were followed on a mean duration of 13 years.
  
  
  RESULTS
  The mortality rate was 1.2%. Eight factors were linked to the lack of recovery at 2 years: low BMI at discharge, low energy and fat intakes, high drive for excessive exercising, high score for perfectionism, for interpersonal distrust and for anxiety, use of tube-feeding and adhesion to treatment (P<0.02). Four factors explained the risk of the binge/purging form at 2 years: having had binge-eating disorder and overweight before AN, having had purging episodes within the first 2 years of AN; having had very high energy intakes through meals and being not treated by tube-feeding. During the 13-year follow-up, very few binge/purging patients turned out to have the restrictive form. Two main factors explained 67% of the variance of menses recovery: having a BMI>18.5 kg/m(2); and having no physical hyperactivity. The recovery rate increased with the elapsing of relapse-free time (P=0.02). After a 13.5-year follow-up, 292 out of the 484 patients were recovered (60.3%), 25.8% had a relatively good outcome, 6.4% a bad outcome and 6.4% a severe outcome. Very few factors were identified as predictors of a good outcome (binge-eating/purging subtype, personality disorder).
authors.affiliation: Service d'Endocrinologie et Nutrition, CHU de Dijon, 2, boulevard de Lattre-de-Tassigny, 21000 Dijon, France. daniel.rigaud@chu-dijon.fr
authors.forename: D
authors.initials: D
authors.lastname: Rigaud
authors.forename: H
authors.initials: H
authors.lastname: Pennacchio
authors.forename: C
authors.initials: C
authors.lastname: Bizeul
authors.forename: V
authors.initials: V
authors.lastname: Reveillard
authors.forename: B
authors.initials: B
authors.lastname: Vergès
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D001007:Anxiety / Q000209:etiology; D015992:Body Mass Index; D003863:Depression / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008599:Menstruation Disturbances / Q000209:etiology; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome