title: CT of the hips in the investigation of protrusio acetabuli in Marfan syndrome. A case control study.
abstract: OBJECTIVE
  To establish the prevalence of protrusio acetabuli (PA) in adults fulfilling the Ghent criteria for Marfan syndrome (MFS), and in a normal adult population.
  
  
  METHODS
  105 adults with probable MFS and 107 controls were included. CT of the hips was obtained. A qualitative assessment of PA was performed. A new method for estimating the degree of PA was introduced with measurement of the parameter CWD (circle-wall distance). Results were compared to an alternative method based on MRI [1].
  
  
  RESULTS
  87 of the study group fulfilled the Ghent criteria of MFS (Ghent positives), and 18 did not (Ghent negatives). PA was diagnosed qualitatively in 74.7% of Ghent positive persons, in 27.8% of Ghent negative persons, and in 3.7% of the controls. CWD was significantly different between the three groups (p < 0.001). A slight but significant gender difference was found in Ghent positive persons only. The alternative method did not differentiate between the groups with respect to PA, but showed a significant difference between genders.
  
  
  CONCLUSIONS
  PA was found significantly more often in MFS persons than in controls. Our method was found to be robust and highly reproducible, giving a direct measurement of pelvic protrusion irrespective of pelvic shape.
authors.affiliation: Faculty of Medicine, University of Oslo, Oslo, Norway. rigmor.lundby@medisin.uio.no
authors.forename: Rigmor
authors.initials: R
authors.lastname: Lundby
authors.forename: Eva
authors.initials: E
authors.lastname: Kirkhus
authors.forename: Svend
authors.initials: S
authors.lastname: Rand-Hendriksen
authors.forename: John
authors.initials: J
authors.lastname: Hald
authors.forename: Are Hugo
authors.initials: AH
authors.lastname: Pripp
authors.forename: Hans-Jørgen
authors.initials: HJ
authors.lastname: Smith
mesh_terms: D000077:Acetabulum / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008875:Middle Aged; D009139:Musculoskeletal Abnormalities / Q000000981:diagnostic imaging*; D012372:ROC Curve; D014057:Tomography, X-Ray Computed / Q000379:methods*