title: Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors.
abstract: In a recent issue of Experimental Neurology, Sauerbeck and colleagues demonstrated that treatment with the peroxisome proliferator-activated receptor (PPAR) agonist Pioglitazone after experimental traumatic brain injury (TBI) in rats was protective against mitochondrial dysfunction, cognitive impairment, cortical tissue loss and microglial activation. In this commentary, we review the key findings of this work and their relevance to previous and future neurotrauma research. More broadly, we speculate about their significance in the context of developing therapeutic strategies for a wide range of neuroinflammatory conditions.
authors.affiliation: Department of Neurological Surgery, University of California, San Francisco, CA 94143–0112, USA. bridgette.semple@ucsf.edu
authors.forename: Bridgette D
authors.initials: BD
authors.lastname: Semple
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Noble-Haeusslein
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004660:Encephalitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008928:Mitochondria / Q000187:drug effects*; D000077205:Pioglitazone; D051381:Rats; D045162:Thiazolidinediones / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077205:Pioglitazone