title: Disruption of prepulse inhibition by 3,4-methylenedioxymethamphetamine (MDMA): comparison between male and female wild-type and 5-HT(1A) receptor knockout mice.
abstract: The aim of this study was to investigate the involvement of serotonin-1A (5-HT(1A)) receptors in the effects of 3,4-methylenedioxymetamphetamine (MDMA) on prepulse inhibition of acoustic startle (PPI) by comparing male and female wild-type (WT) mice and 5-HT(1A) receptor knockout (1AKO) mice. MDMA dose-dependently decreased PPI in male and female mice although female mice were more sensitive at the 100-ms inter-stimulus interval (ISI). In male mice, 10 mg/kg MDMA disrupted PPI in 1AKO but not in WT controls. There was no genotype difference at higher or lower doses of MDMA. In female mice, there was no difference between genotypes at any dose of MDMA. Average startle was reduced by 10 mg/kg and 20 mg/kg MDMA similarly in male and female mice and all genotypes. These results show an involvement of 5-HT(1A) receptors in the effect of MDMA on PPI in male, but not female mice.
authors.affiliation: Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Victoria, Australia. m.vandenbuuse@mhri.edu.au
authors.forename: Maarten
authors.initials: M
authors.lastname: van den Buuse
authors.forename: Thorsten
authors.initials: T
authors.lastname: Becker
authors.forename: Perrin
authors.initials: P
authors.lastname: Kwek
authors.forename: Sally
authors.initials: S
authors.lastname: Martin
authors.forename: Emma
authors.initials: E
authors.lastname: Ruimschotel
authors.forename: Victoria
authors.initials: V
authors.lastname: Risbrough
mesh_terms: D015104:3,4-Methylenedioxyamphetamine / Q000008:administration & dosage / Q000633:toxicity*; D000161:Acoustic Stimulation; D018759:Adrenergic Uptake Inhibitors / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006213:Hallucinogens / Q000008:administration & dosage / Q000633:toxicity*; D006579:Heterozygote; D013287:Illicit Drugs / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009433:Neural Inhibition / Q000187:drug effects*; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000502:physiology*; D013216:Reflex, Startle / Q000187:drug effects; D012727:Sex Characteristics
chemical_list: D018759:Adrenergic Uptake Inhibitors; D006213:Hallucinogens; D013287:Illicit Drugs; D044282:Receptor, Serotonin, 5-HT1A; D015104:3,4-Methylenedioxyamphetamine