title: Differential global profiling as a new analytical strategy for revealing micropollutant treatment by-products: application to ethinylestradiol and chlorination water treatment.
abstract: The detection and structural elucidation of micropollutants treatment by-products are major issues to estimate efficiencies of the processes employed for drinking water production versus endocrine disruptive compounds contamination. This issue was mainly investigated at the laboratory scale and in high concentration conditions. However, potential by-products generated after chlorination can be influenced by the dilution factor employed in real conditions. The present study proposes a new methodology borrowed to the metabolomic science, using liquid chromatography coupled to high-resolution mass spectrometry, in order to reveal potential chlorination by-products of ethinylestradiol in spiked real water samples at the part-per-billion level (5 μg L(-1)). Conventional targeted measurements first demonstrated that chlorination with sodium hypochlorite (0.8 mg L(-1)) led to removals of ethinylestradiol over 97%. Then, the developed differential global profiling approach permitted to reveal eight chlorination by-products of EE2, six of them being described for the first time. Among these eight halogenated compounds, five have been structurally identified, demonstrating the potential capabilities of this new methodology applied to environmental samples.
authors.affiliation: ONIRIS, USC 2013, LABERCA, Nantes, France. gael.gervais@oniris-nantes.fr
authors.forename: Gaël
authors.initials: G
authors.lastname: Gervais
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Bichon
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.forename: Fabrice
authors.initials: F
authors.lastname: Monteau
authors.forename: Gaëla
authors.initials: G
authors.lastname: Leroy
authors.forename: Lauriane
authors.initials: L
authors.lastname: Barritaud
authors.forename: Mathilde
authors.initials: M
authors.lastname: Chachignon
authors.forename: Valérie
authors.initials: V
authors.lastname: Ingrand
authors.forename: Pascal
authors.initials: P
authors.lastname: Roche
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D017606:Chlorine Compounds / Q000032:analysis*; D004202:Disinfectants / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D004997:Ethinyl Estradiol / Q000032:analysis*; D005618:Fresh Water / Q000737:chemistry; D054879:Halogenation; D014874:Water Pollutants, Chemical / Q000032:analysis*; D018508:Water Purification; D014881:Water Supply / Q000032:analysis
chemical_list: D017606:Chlorine Compounds; D004202:Disinfectants; D014874:Water Pollutants, Chemical; D004997:Ethinyl Estradiol