title: SIRT-ain relief from age-inducing stress.
abstract: Aging is one of the most fundamental biological processes. It results in a decline in physiological function and an increased risk for pernicious diseases such as cancer. Oxidative stress has been proposed as a major cause of aging, but experimental tests of this hypothesis have been discouraging. Calorie restriction (CR) prevents age-related decline, but there are still gaps in our knowledge of the exact mechanisms underlying this feat. Finally, a tenuous balance exists between aging and cancer, calling for a search for interventions that prevent both aging and cancer. Recent work on the mammalian sirtuin SIRT3 has shed light on these long-standing issues and suggested new approaches to ameliorate the ravages of aging.
authors.affiliation: Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Yufei
authors.initials: Y
authors.lastname: Liu
authors.forename: Danica
authors.initials: D
authors.lastname: Chen
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D031204:Caloric Restriction; D008928:Mitochondria / Q000201:enzymology; D009369:Neoplasms / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology*; D056566:Sirtuin 3 / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D000099156:Superoxide Dismutase 2
chemical_list: D056566:Sirtuin 3; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2