title: IR, 1H NMR, mass, XRD and TGA/DTA investigations on the ciprofloxacin/iodine charge-transfer complex.
abstract: The charge-transfer complex (CTC) of ciprofloxacin drug (CIP) as a donor with iodine (I(2)) as a sigma acceptor has been studied spectrophotometrically in CHCl(3). At maximum absorption bands, the stoichiometry of CIP:iodine system was found to be 1:1 ratio according to molar ratio method. The essential spectroscopic data like formation constant (K(CT)), molar extinction coefficient (ɛ(CT)), standard free energy (ΔG°), oscillator strength (f), transition dipole moment (μ), resonance energy (R(N)) and ionization potential (I(D)) were estimated. The spectroscopic techniques such as IR, (1)H NMR, mass and UV-vis spectra and elemental analyses (CHN) as well as TG-DTG and DTA investigations were used to characterize the chelating behavior of CIP/iodine charge-transfer complex. The iodine CT interaction was associated with a presence of intermolecular hydrogen bond. The X-ray investigation was carried out to investigate the iodine doping in the synthetic CT complex.
authors.affiliation: Department of Chemistry, Faculty of Science-Port Said, Port Said University, Egypt. msrefat@yahoo.com
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
authors.forename: W F
authors.initials: WF
authors.lastname: El-Hawary
authors.forename: Mohamed A A
authors.initials: MA
authors.lastname: Moussa
mesh_terms: D000042:Absorption; D002725:Chloroform / Q000737:chemistry; D002939:Ciprofloxacin / Q000737:chemistry*; D004583:Electrons; D007455:Iodine / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008970:Molecular Weight; D010783:Photometry; D011522:Protons; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013818:Thermogravimetry; D017186:Titrimetry; D014961:X-Ray Diffraction
chemical_list: D011522:Protons; D002939:Ciprofloxacin; D002725:Chloroform; D007455:Iodine