title: [Platelet structure and functions (a review of literature). Part 1].
abstract: The paper reviews literature updates on the organization and specific features of megakaryocytopoiesis, the mechanisms of its regulation, possible ways for platelets to occur from megakaryocytes. It characterizes thrombocytopoiesis, by describing the detailed structural organization of platelets and gives data on the relationship of the morphofunctional features of platelets to the ploidy of megakaryocytes that give rise to the latter. The structure and clinical value of a number of platelet activation markers, such as CD41/CD61, CD42, CD62p, platelet-leukocyte aggregates, microvesicles, are described.
authors.forename: A I
authors.initials: AI
authors.lastname: Mininkova
mesh_terms: D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000166:cytology* / Q000502:physiology; D006801:Humans; D039661:Integrin beta3 / Q000097:blood; D008533:Megakaryocytes / Q000166:cytology; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism; D040201:Platelet Membrane Glycoprotein IIb / Q000097:blood; D011003:Ploidies; D034061:Thrombopoiesis
chemical_list: D015415:Biomarkers; D039661:Integrin beta3; D019007:P-Selectin; D019038:Platelet Glycoprotein GPIb-IX Complex; D040201:Platelet Membrane Glycoprotein IIb