title: Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson's disease.
abstract: There is a need for objective imaging markers of Parkinson's disease status and progression. Positron emission tomography and single photon emission computed tomography studies have suggested patterns of abnormal cerebral perfusion in Parkinson's disease as potential functional biomarkers. This study aimed to identify an arterial spin labelling magnetic resonance-derived perfusion network as an accessible, non-invasive alternative. We used pseudo-continuous arterial spin labelling to measure cerebral grey matter perfusion in 61 subjects with Parkinson's disease with a range of motor and cognitive impairment, including patients with dementia and 29 age- and sex-matched controls. Principal component analysis was used to derive a Parkinson's disease-related perfusion network via logistic regression. Region of interest analysis of absolute perfusion values revealed that the Parkinson's disease pattern was characterized by decreased perfusion in posterior parieto-occipital cortex, precuneus and cuneus, and middle frontal gyri compared with healthy controls. Perfusion was preserved in globus pallidus, putamen, anterior cingulate and post- and pre-central gyri. Both motor and cognitive statuses were significant factors related to network score. A network approach, supported by arterial spin labelling-derived absolute perfusion values may provide a readily accessible neuroimaging method to characterize and track progression of both motor and cognitive status in Parkinson's disease.
authors.affiliation: Van der Veer Institute for Parkinson’s and Brain Research, Christchurch 8011, New Zealand. tracy.melzer@vanderveer.org.nz
authors.forename: Tracy R
authors.initials: TR
authors.lastname: Melzer
authors.forename: Richard
authors.initials: R
authors.lastname: Watts
authors.forename: Michael R
authors.initials: MR
authors.lastname: MacAskill
authors.forename: John F
authors.initials: JF
authors.lastname: Pearson
authors.forename: Sina
authors.initials: S
authors.lastname: Rüeger
authors.forename: Toni L
authors.initials: TL
authors.lastname: Pitcher
authors.forename: Leslie
authors.initials: L
authors.lastname: Livingston
authors.forename: Charlotte
authors.initials: C
authors.lastname: Graham
authors.forename: Ross
authors.initials: R
authors.lastname: Keenan
authors.forename: Ajit
authors.initials: A
authors.lastname: Shankaranarayanan
authors.forename: David C
authors.initials: DC
authors.lastname: Alsop
authors.forename: John C
authors.initials: JC
authors.lastname: Dalrymple-Alford
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D001931:Brain Mapping; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D010477:Perfusion; D049268:Positron-Emission Tomography / Q000379:methods; D025341:Principal Component Analysis; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods