title: Actions of a coral toxin analogue (bipinnatin-B) on an insect nicotinic acetylcholine receptor.
abstract: The lophotoxin analogue, bipinnatin-B, is a potent neurotoxin isolated from the gorgonian coral Pseudopterogorgia bipinnata. When tested on the cell body of an identified motor neurone, the fast coxal depressor motor neurone (Df) in the cockroach metathoracic ganglion, bipinnatin-B, at concentrations of 10 micronM,partially blocked nicotine-induced depolarization. Blockade of the response to nicotine was almost complete at 30 micronM bipinnatin-B, and was partially reversible on rebathing the preparation in normal saline. Responses of the same neurone to GABA were unaffected by 30 micronM bipinnatin-B.
authors.affiliation: AFRC Luboratory of Molecular Signalling, Department of Zoology, University of Cambridge,Cambridge, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Bai
authors.forename: S N
authors.initials: SN
authors.lastname: Abramson
authors.forename: D B
authors.initials: DB
authors.lastname: Sattelle
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry; D008297:Male; D008387:Marine Toxins / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects; D010526:Periplaneta / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000502:physiology; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D008387:Marine Toxins; D011978:Receptors, Nicotinic; D012717:Sesquiterpenes; D005680:gamma-Aminobutyric Acid; C069649:bipinnatin B