title: Biolimus-eluting biodegradable polymer-coated stent versus bare metal stent in acute ST-elevation and non-ST elevation myocardial infarction: Justification for biodegradable polymer-coated stent in acute coronary syndrome (JANICE) registry.
abstract: OBJECTIVE
  We evaluated the efficacy and safety of a biolimus- eluting biodegradable polymer-coated stent (BES) in patients with ST-segment elevation and non ST-segment elevation acute myocardial infarction (AMI).
  
  
  RESULTS
  This was an observational study involving a single centre patient registry. We compared the rates of cardiac death, myocardial infarction, target vessel revascularization (TVR) and composite end point of cardiac death and myocardial infarction at 24 months in 106 patients who received BES versus 94 patients who received an otherwise similar bare metal stent (BMS) during percutaneous coronary intervention for AMI. There was no significant difference in the rate of cardiac death (0.9% versus 7.4%; P = 0.09), myocardial infarction (4.7% versus 3.2%; P = 0.69), stent thrombosis (0.9% versus 3.2%; P = 0.30) or cardiac death and myocardial infarction (5.7% versus 10.6%; P = 0.30) between the two groups. The rate of TVR was significantly higher in the BMS group (1.9% versus 8.5%; P = 0.04), with patients receiving BMS being four times more likely to require TVR.
  
  
  CONCLUSIONS
  The use of BES in selected patients with AMI appears to be safe and is associated with significantly reduced rate of TVR, when compared with an otherwise similar BMS.
authors.affiliation: Tan Tock Seng Hospital, Cardiology, Singapore, Singapore. powlichia@gmail.com
authors.forename: Pow-Li
authors.initials: PL
authors.lastname: Chia
authors.forename: Arul
authors.initials: A
authors.lastname: Earnest
authors.forename: Jimmy
authors.initials: J
authors.lastname: Lim
mesh_terms: D020341:Absorbable Implants; D054058:Acute Coronary Syndrome / Q000601:surgery*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000900:Anti-Bacterial Agents; D003643:Death; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D019370:Observation; D011108:Polymers; D012042:Registries; D012189:Retrospective Studies; D012449:Safety; D020123:Sirolimus / Q000031:analogs & derivatives; D015607:Stents; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D008670:Metals; D011108:Polymers; C518022:umirolimus; D020123:Sirolimus