title: Transcription and replication: breaking the rules of the road causes genomic instability.
abstract: Replication and transcription machineries progress at high speed on the same DNA template, which inevitably causes traffic accidents. Problems are not only caused by frontal collisions between polymerases, but also by cotranscriptional R-loops. These RNA-DNA hybrids induce genomic instability by blocking fork progression and could be implicated in the development of cancer.
authors.affiliation: Institute of Human Genetics, CNRS UPR, Montpelier, France.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Poveda
authors.forename: Mikael
authors.initials: M
authors.lastname: Le Clech
authors.forename: Philippe
authors.initials: P
authors.lastname: Pasero
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004261:DNA Replication / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D042822:Genomic Instability; D006801:Humans; D008957:Models, Genetic; D012313:RNA / Q000235:genetics / Q000378:metabolism; D011995:Recombination, Genetic; D013698:Templates, Genetic; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases