title: Serum p53 antibody is a useful tumor marker of early colorectal cancer.
abstract: The aim of this study was to evaluate the significance of preoperative serum p53 antibodies (Abs) in patients with colorectal cancer. Between 2007 and 2008, serum p53 Abs were measured by enzyme-linked immunoabsorbent assay in 100 consecutive patients with colorectal cancer. Relationships between clinicopathologic features and the preoperative presence of serum p53 Abs were evaluated. Serum p53 Abs were positive in approximately 30%, regardless of the depth of tumor invasion--sm (submucosa), mp (muscularis propria), or ss (subserosa). Two patients among 23 T1 patients (9%) had lymph node metastasis. These 2 patients belonged to a group of 7 patients who were determined positive for serum p53 Abs (29%), although none of 16 patients negative for serum p53 Abs had lymph node metastasis, regardless of vascular invasion. Preoperative serum p53 Abs do not seem to be a marker of tumor progression but may be a useful marker for detecting high risk of lymph node metastasis in T1 colorectal cancer.
authors.affiliation: Department of Surgery, Kashiwa Hospital, Jikei University School of Medicine.
authors.forename: Rohta
authors.initials: R
authors.lastname: Noaki
authors.forename: Hidejiro
authors.initials: H
authors.lastname: Kawahara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takuro
authors.initials: T
authors.lastname: Ushigome
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018709:Statistics, Nonparametric; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53