title: Acquired opercular epilepsy with oromotor dysfunction: magnetoencephalographic analysis and efficacy of corticosteroid therapy.
abstract: The authors describe herein the magnetoencephalographic findings and long-term outcome of a girl with acquired opercular epilepsy with oromotor dysfunction. She presented with brief episodes of unconsciousness, tremulous movements of the upper limbs, and negative myoclonus, in addition to convulsive seizures. She also had prolonged episodes of dysarthria and oral motor dysfunction, a gradual decrease in speech output, impairment of finger movements, and deterioration in cognitive performance over several years. Her electroencephalography (EEG) recordings showed notable continuous sharp or sharp-slow discharges during sleep. Brain magnetic resonance images revealed no structural anomalies. Magnetoencephalographic analysis showed broadly distributed epileptic foci around the sylvian fissure, including a secondary source, explaining the specific prolonged neurological dysfunction. Antiepileptic drugs could control her seizures; however, they did not improve the other neurological symptoms or epileptiform discharge on EEG. Administration of low-dose prednisolone over a long period was effective for improving the neurological impairments of this patient.
authors.affiliation: Department of Pediatrics, Epilepsy Center, Nishi-Niigata Chuo National Hospital, Niigata, Japan. jtohyama@masa.go.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Tohyama
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Akasaka
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ohashi
authors.forename: Yu
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D002648:Child; D004401:Dysarthria / Q000188:drug therapy / Q000503:physiopathology*; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D015225:Magnetoencephalography / Q000379:methods; D009044:Motor Cortex / Q000503:physiopathology*; D009069:Movement Disorders / Q000188:drug therapy / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones