title: Validation of the GRACE Risk score for hospital mortality in patients with acute coronary syndrome in the Arab Middle East.
abstract: Our objective was to validate the Global Registry of Acute Coronary Events (GRACE) risk score for in-hospital mortality in a Middle Eastern acute coronary syndrome (ACS) population enrolled in the Gulf Registry of Acute Coronary Events (Gulf RACE). Out of 8176, unselected, consecutive patients with ACS, during 6 months in 2006 and 2007 from 63 hospitals in 6 Arab countries in the Middle East Gulf region, 7709 (94.3%) with available data were included. The main outcome measures were discriminatory performance (using C-index) and calibration of the GRACE risk score (in-hospital mortality predicted by GRACE risk score versus the actual mortality). In-hospital mortality in the Gulf RACE was 3.09% (n = 238). The discriminatory performance of the GRACE risk scores in the Gulf RACE was good overall (C-index = 0.86). Observed and predicted risk corresponded well in each stratum of risk of in-hospital mortality. This suggests its suitability for clinical use in this patient population.
authors.affiliation: Dubai Heart Centre, Dubai Health Authority, United Arab Emirates. ahyusufali@dha.gov.ae
authors.forename: Afzalhussein
authors.initials: A
authors.lastname: Yusufali
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zubaid
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Al-Zakwani
authors.forename: Alawi A
authors.initials: AA
authors.lastname: Alsheikh-Ali
authors.forename: Mouaz H
authors.initials: MH
authors.lastname: Al-Mallah
authors.forename: Jassim
authors.initials: J
authors.lastname: Al Suwaidi
authors.forename: Wael
authors.initials: W
authors.lastname: AlMahmeed
authors.forename: Wafa
authors.initials: W
authors.lastname: Rashed
authors.forename: Kadhim
authors.initials: K
authors.lastname: Sulaiman
authors.forename: Haitham
authors.initials: H
authors.lastname: Amin
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology*; D000368:Aged; D018912:Arabs / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality / Q000208:ethnology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008877:Middle East / Q000453:epidemiology; D011237:Predictive Value of Tests; D012042:Registries; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors