title: Microcirculatory dysfunction in sepsis.
abstract: Septic shock is a common and deadly disease that traditionally has been diagnosed and treated by evaluation and optimization of global hemodynamic indices. However, microcirculatory dysfunction is a critically important element in the pathophysiology of this disease. New techniques of in vivo video microscopy permit the assessment of microcirculatory function in human subjects. With the advent of these techniques, the microcirculation may represent a new frontier for developing novel therapies for sepsis.
authors.affiliation: Department of Surgery, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, NJ 08103, USA. lundy-david@cooperhealth.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Lundy
authors.forename: Stephen
authors.initials: S
authors.lastname: Trzeciak
mesh_terms: D001808:Blood Vessels / Q000503:physiopathology*; D016638:Critical Illness; D004727:Endothelium / Q000098:blood supply; D006801:Humans; D008833:Microcirculation; D009569:Nitric Oxide / Q000502:physiology; D018805:Sepsis / Q000503:physiopathology*
chemical_list: D009569:Nitric Oxide