title: Efficacy of amprolium for the treatment of pathogenic Eimeria species in Boer goat kids.
abstract: This study evaluated the efficacy of two different doses of amprolium in goats heavily infected with pathogenic Eimeria species. Forty Boer goat kids ranging from 3 to 5 months of age with naturally occurring coccidiosis were randomly divided into 2 groups and treated orally with amprolium at doses of 10mg/kg daily for 5 days (n=20) or 50mg/kg daily for 5 days (n=20). The Eimeria oocyst per gram concentrations were significantly reduced on day 7 in the kids that received amprolium at 50mg/kg, however oocyst concentrations were not significantly reduced in goats that received the 10mg/kg dose. Out of 100 Eimeria oocysts identified from a pooled fecal sample, E. christenseni was the most frequently identified (52%) coccidial species present. The results of this trial indicate that amprolium can be an effective treatment for pathogenic Eimeria species in goat kids, however higher and extralabel doses (50mg/kg) should be used.
authors.affiliation: Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, United States.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Young
authors.forename: Mark L
authors.initials: ML
authors.lastname: Alley
authors.forename: Derek M
authors.initials: DM
authors.lastname: Foster
authors.forename: Geof W
authors.initials: GW
authors.lastname: Smith
mesh_terms: D000670:Amprolium / Q000008:administration & dosage*; D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy* / Q000469:parasitology / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage*; D004539:Eimeria / Q000254:growth & development*; D005243:Feces / Q000469:parasitology; D005260:Female; D015511:Goat Diseases / Q000188:drug therapy* / Q000469:parasitology*; D006041:Goats; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary
chemical_list: D003049:Coccidiostats; D000670:Amprolium