title: Within-day temporal patterns of smoking, withdrawal symptoms, and craving.
abstract: We examined the temporal relationships between smoking frequency and craving and withdrawal. 351 heavy smokers (≥15 cigarettes per day) used ecological momentary assessment and electronic diaries to track smoking, craving, negative affect, arousal, restlessness, and attention disturbance in real time over 16 days. The waking day was divided into 8 2-h "bins" during which cigarette counts and mean levels of craving and withdrawal were computed. Cross-sectional analyses showed no association between restlessness and smoking, and arousal and smoking, but craving (b=0.65, p<0.01) was positively associated, and negative affect (b=-0.20, p<0.01), and attention disturbance (b=-0.24, p<0.01) were inversely associated with smoking. In prospective lagged analyses, higher craving predicted more subsequent smoking and higher smoking predicted lower craving (p's<0.01). Higher restlessness also predicted more subsequent smoking and higher smoking predicted lower restlessness (p's<0.01). Higher negative affect did not predict later smoking, but more smoking preceded lower negative affect (p<0.01). Neither attention disturbance nor arousal predicted, or were predicted by variations in smoking. In short, smoking exhibits time-lagged, reciprocal relationships with craving and restlessness, and a one-way predictive relationship with negative affect. Temporal patterns of craving and restlessness may aid in the design of smoking cessation interventions.
authors.affiliation: University of Pittsburgh, Pittsburgh, PA, USA. chandr45@msu.edu
authors.forename: Siddharth
authors.initials: S
authors.lastname: Chandra
authors.forename: Deborah
authors.initials: D
authors.lastname: Scharf
authors.forename: Saul
authors.initials: S
authors.lastname: Shiffman
mesh_terms: D000328:Adult; D016739:Behavior, Addictive; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D005260:Female; D055991:Health Records, Personal; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D010919:Placebos; D011446:Prospective Studies; D012907:Smoking / Q000453:epidemiology / Q000523:psychology*; D016540:Smoking Cessation / Q000523:psychology*; D013375:Substance Withdrawal Syndrome / Q000523:psychology*; D011795:Surveys and Questionnaires; D061485:Tobacco Use Cessation Devices; D014029:Tobacco Use Disorder / Q000453:epidemiology* / Q000523:psychology; D055815:Young Adult
chemical_list: D018722:Nicotinic Agonists; D010919:Placebos; D009538:Nicotine