title: Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles.
abstract: OBJECTIVE
  Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality.
  
  
  METHODS
  We performed 36 months follow-up study in 122 haemodialysis (HD) patients. HDL size and subclass distribution were determined by gradient gel electrophoresis. Baseline characteristics of the patients were evaluated for the prediction of mortality.
  
  
  RESULTS
  Cox regressions analysis showed that patients with small-sized HDL particles had 2.8-fold higher risk of lethal outcome (P<0.05). Concomitant presence of small-sized HDL particles and increased hsCRP concentration were significantly associated with reduced survival rate (HR=3.907; P<0.05). Observed relationships persisted after adjustment for serum lipid and lipoprotein concentrations.
  
  
  CONCLUSIONS
  Our results indicate that small-sized HDL particles alone and combined with elevated hsCRP concentrations are independent predictors of reduced survival in HD patients.
authors.affiliation: Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Vekic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Zeljkovic
authors.forename: Natasa
authors.initials: N
authors.lastname: Bogavac-Stanojevic
authors.forename: Zorana
authors.initials: Z
authors.lastname: Jelic-Ivanovic
authors.forename: Vesna
authors.initials: V
authors.lastname: Spasojevic-Kalimanovska
authors.forename: Sanja
authors.initials: S
authors.lastname: Simic-Ogrizovic
authors.forename: Violeta
authors.initials: V
authors.lastname: Dopsaj
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasic
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000401:mortality*; D008075:Lipoproteins, HDL / Q000097:blood*; D016016:Proportional Hazards Models; D006435:Renal Dialysis
chemical_list: D008075:Lipoproteins, HDL; D002097:C-Reactive Protein