title: Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasound.
abstract: This paper describes the use of Au nanocages covered with smart, thermally-responsive polymers for controlled release with high-intensity focused ultrasound (HIFU). HIFU is a highly precise medical procedure that uses focused ultrasound to heat and destroy pathogenic tissue rapidly and locally in a non-invasive or minimally invasive manner. The released dosage could be remotely controlled by manipulating the power of HIFU and/or the duration of exposure. We demonstrated localized release within the focal volume of HIFU by using gelatin phantom samples containing dye-loaded Au nanocages. By placing chicken breast tissues on top of the phantoms, we further demonstrated the feasibility of this system for controlled release at depths up to 30 mm. Because it can penetrate more deeply into soft tissues than near-infrared light, HIFU is a potentially more effective external stimulus for rapid, on-demand drug release.
authors.affiliation: Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA.
authors.forename: Weiyang
authors.initials: W
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Cai
authors.forename: Chulhong
authors.initials: C
authors.lastname: Kim
authors.forename: Guorong
authors.initials: G
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Deng
authors.forename: Miaoxin
authors.initials: M
authors.lastname: Yang
authors.forename: Jingyi
authors.initials: J
authors.lastname: Chen
authors.forename: Samuel
authors.initials: S
authors.lastname: Achilefu
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D000818:Animals; D001940:Breast / Q000528:radiation effects*; D002645:Chickens; D006046:Gold / Q000737:chemistry / Q000528:radiation effects* / Q000627:therapeutic use*; D011829:Radiation Dosage; D013010:Sonication / Q000379:methods*
chemical_list: D006046:Gold