title: Alkyne-mediated domino hydroformylation/double cyclization: mechanistic insight and synthesis of (±)-tashiromine.
abstract: A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.
authors.affiliation: Department of Chemistry, National Chung Hsing University, Taichung, Taiwan, 402, ROC. wchiou@dragon.nchu.edu.tw
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chiou
authors.forename: Yi-Huei
authors.initials: YH
authors.lastname: Lin
authors.forename: Guei-Tang
authors.initials: GT
authors.lastname: Chen
authors.forename: Yu-Kai
authors.initials: YK
authors.lastname: Gao
authors.forename: Yu-Che
authors.initials: YC
authors.lastname: Tseng
authors.forename: Chien-Lun
authors.initials: CL
authors.lastname: Kao
authors.forename: Jui-Chi
authors.initials: JC
authors.lastname: Tsai