title: Cytological, immunohistochemical and mutational analysis of a gastric gastrointestinal stromal tumour in a cat.
abstract: Gastrointestinal stromal tumours (GISTs) represent a distinctive group of primary mesenchymal tumours of the gastrointestinal tract identified immunohistochemically by expression of CD117. A 10-year-old neutered female domestic shorthair cat with a history of recurrent vomiting was examined. The presence of a gastric mass was recognized and a laparotomy was performed. Cytological examination was consistent with a low-grade malignant mesenchymal tumour and histopathological investigation suggested myogenic differentiation of tumour cells. The diagnosis of GIST was confirmed by immunohistochemical expression of CD117. Sequence analysis of the KIT gene identified a deletion in exon 11. The same mutation is found often in human GISTs.
authors.affiliation: Department of Veterinary Public Health and Animal Pathology, Faculty of Veterinary Medicine, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy. giuliano.bettini@unibo.it
authors.forename: M
authors.initials: M
authors.lastname: Morini
authors.forename: F
authors.initials: F
authors.lastname: Gentilini
authors.forename: M
authors.initials: M
authors.lastname: Pietra
authors.forename: A
authors.initials: A
authors.lastname: Spadari
authors.forename: M E
authors.initials: ME
authors.lastname: Turba
authors.forename: L
authors.initials: L
authors.lastname: Mandrioli
authors.forename: G
authors.initials: G
authors.lastname: Bettini
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000235:genetics* / Q000473:pathology*; D002415:Cats; D004252:DNA Mutational Analysis; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary*
chemical_list: D019009:Proto-Oncogene Proteins c-kit