title: Aging affects human B cell responses.
abstract: Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.
authors.affiliation: Department of Microbiology and Immunology, University of Miami Miller School of Medicine, RMSB 3146A, P.O. Box 016960(R-138), Miami, FL 33101, USA. dfrasca@med.miami.edu
authors.forename: Daniela
authors.initials: D
authors.lastname: Frasca
authors.forename: Bonnie B
authors.initials: BB
authors.lastname: Blomberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate; D017578:Immunoglobulin Class Switching / Q000187:drug effects; D007136:Immunoglobulins / Q000145:classification / Q000276:immunology*; D009980:Influenza A virus / Q000254:growth & development; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD; D007136:Immunoglobulins; D007252:Influenza Vaccines