title: Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism.
abstract: BACKGROUND
  IL1b (IL1B or IL1β), a key modulator of the immune response, exerts its functions mainly via IL6 regulation. Fatty meals cause transient hypertriglyceridemia and are considered to be proinflammatory, but the extent of these responses shows high interindividual susceptibility.
  
  
  OBJECTIVE
  We evaluated the influence of a genetic variant located in the promoter region of IL1B (-1473G/C) on fasting and postprandial lipids and IL6.
  
  
  METHODS
  A total of 477 people over age 65 yr were genotyped for IL1B -1473G/C, and we evaluated fasting lipids depending on genotype. Then, 88 healthy young men were also genotyped and were fed a saturated fatty acid-rich meal. Serial blood samples were drawn for 11 h after the meal, and lipid fractions and IL6 were assayed. MAIN OUTCOME AND INTERVENTIONS: Fasting lipids were studied in the aged persons. Fasting and postprandial measurements of lipids and IL6 were performed in the healthy young men.
  
  
  RESULTS
  In the aged persons, CC subjects (minor allele homozygotes) showed higher triglyceride (P = 0.002) and cholesterol (P = 0.011) levels. Healthy young male carriers of the minor C allele showed higher postprandial triglycerides (P = 0.037), and those carried into large triglyceride-rich lipoproteins (P = 0.004). In addition, they showed higher postprandial IL6 concentrations (P = 0.008).
  
  
  CONCLUSIONS
  Our work shows that inflammatory genes may regulate fasting and postprandial lipids because the carriers of the minor allele of an IL gene variant have altered lipid metabolism. To reinforce these gene-phenotype findings, IL6 (the natural effector of IL1B) was increased in these persons.
authors.affiliation: Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigación Biomedica de Cordoba/Hospital Universitario Reina Sofía/Universidad de Córdoba and CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado-Lista
authors.forename: Antonio
authors.initials: A
authors.lastname: Garcia-Rios
authors.forename: Pablo
authors.initials: P
authors.lastname: Perez-Martinez
authors.forename: Juan
authors.initials: J
authors.lastname: Solivera
authors.forename: Elena M
authors.initials: EM
authors.lastname: Yubero-Serrano
authors.forename: Francisco
authors.initials: F
authors.lastname: Fuentes
authors.forename: Laurence D
authors.initials: LD
authors.lastname: Parnell
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Purificacion
authors.initials: P
authors.lastname: Gomez
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jimenez-Gomez
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Gomez-Luna
authors.forename: Carmen
authors.initials: C
authors.lastname: Marin
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Belisle
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodriguez-Cantalejo
authors.forename: Simin N
authors.initials: SN
authors.lastname: Meydani
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ordovas
authors.forename: Francisco
authors.initials: F
authors.lastname: Perez-Jimenez
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004041:Dietary Fats / Q000378:metabolism; D005215:Fasting / Q000502:physiology; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015850:Interleukin-6 / Q000378:metabolism*; D008074:Lipoproteins / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism; D008297:Male; D019518:Postprandial Period / Q000235:genetics / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014280:Triglycerides / Q000378:metabolism*; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D053583:Interleukin-1beta; D015850:Interleukin-6; D008074:Lipoproteins; D014280:Triglycerides