title: Primary squamous cell carcinoma associated with ovarian endometriosis: a case report and literature review.
abstract: Primary squamous cell carcinoma (SCC) associated with ovarian endometriosis is extremely rare and has a poor prognosis due to insufficient information on the optimal postoperative treatment. Here, we describe the response of this tumor to the administration of paclitaxel-carboplatin. A 45-year-old woman diagnosed with stage IIIc primary SCC of the ovary associated with endometriosis underwent optimal surgery followed by six courses of chemotherapy at 3-week intervals with paclitaxel and carboplatin. She tolerated the chemotherapy well and remained without evidence of disease during first-line chemotherapy. Two months later, she was readmitted with recurrence of a pelvic tumor. Although she was treated with chemotherapy (weekly paclitaxel and chemotherapeutic regimen of irinotecan + mitomycin C), the tumor was resistant to second-line and third-line chemotherapy and she died 15 months after surgery. Paclitaxel-carboplatin administration may be an effective treatment for primary SCC of the ovary but further studies are required to investigate it true efficacy in the treatment of this disease.
authors.affiliation: Department of Obstetrics and Gynecology, Takaoka City Hospital, 4-1 Takara-machi, Takaoka, Toyama 933-8550, Japan. yoshihiro_yamakawa@municipal-hp-takaoka.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Michiyo
authors.initials: M
authors.lastname: Ushijima
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kato
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D004715:Endometriosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007813:Laparotomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D017239:Paclitaxel / Q000627:therapeutic use*; D010386:Pelvic Neoplasms / Q000175:diagnosis / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016190:Carboplatin; D017239:Paclitaxel