title: Magnetic resonance imaging-guided osseous biopsy in children with chronic recurrent multifocal osteomyelitis.
abstract: OBJECTIVE
  To report the safety and diagnostic performance of magnetic resonance (MRI)--guided core biopsy of osseous lesions in children with chronic recurrent multifocal osteomyelitis (CRMO) that were visible on MRI but were occult on radiography and computed tomography (CT).
  
  
  METHODS
  A retrospective analysis of MRI-guided osseous biopsy performed in seven children (four girls and three boys; mean age 13 years (range 11 to 14) with CRMO was performed. Indication for using MRI guidance was visibility of lesions by MRI only. MRI-guided procedures were performed with 0.2-Tesla (Magnetom Concerto; Siemens, Erlangen, Germany; n = 5) or 1.5-T (Magnetom Espree; Siemens; n = 2) open MRI systems. Core needle biopsy was obtained using an MRI-compatible 4-mm drill system. Conscious sedation or general anesthesia was used. Parameters evaluated were lesion visibility, technical success, procedure time, complications and microbiology, cytology, and histopathology findings.
  
  
  RESULTS
  Seven of seven (100%) targeted lesions were successfully visualized and sampled. All obtained specimens were sufficient for histopathological analysis. Length of time of the procedures was 77 min (range 64 to 107). No complications occurred. Histopathology showed no evidence of malignancy, which was confirmed at mean follow-up of 50 months (range 28 to 78). Chronic nonspecific inflammation characteristic for CRMO was present in four of seven (58%) patients, and edema with no inflammatory cells was found in three of seven (42%) patients. There was no evidence of infection in any patient.
  
  
  CONCLUSIONS
  MRI-guided osseous biopsy is a safe and accurate technique for the diagnosis of pediatric CRMO lesions that are visible on MRI only.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. jfritz9@jhmi.edu
authors.forename: Jan
authors.initials: J
authors.lastname: Fritz
authors.forename: Nikolay
authors.initials: N
authors.lastname: Tzaribachev
authors.forename: Christoph
authors.initials: C
authors.lastname: Thomas
authors.forename: Manfred
authors.initials: M
authors.lastname: Wehrmann
authors.forename: Marius S
authors.initials: MS
authors.lastname: Horger
authors.forename: John A
authors.initials: JA
authors.lastname: Carrino
authors.forename: Claudius W
authors.initials: CW
authors.lastname: König
authors.forename: Philippe L
authors.initials: PL
authors.lastname: Pereira
mesh_terms: D000293:Adolescent; D001707:Biopsy, Needle / Q000379:methods*; D002648:Child; D005260:Female; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional; D008297:Male; D010019:Osteomyelitis / Q000473:pathology*; D012189:Retrospective Studies