title: Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome.
abstract: Atypical hemolytic uremic syndrome (aHUS) is a rare form of complement dysregulation disease, and recently various reports have shown that it is associated with one or more mutations in the complement regulatory genes including complement factor H (CFH). Plasma exchange is a therapeutic option for adult patients, but not for a very young infant because of a potential side effect of therapeutic plasma exchange (TPE) itself. Herein, we describe a case of successful treatment of early onset aHUS associated with a novel CFH mutation with total 21 sessions of TPE over a period of 46 days in 3.2 kg 23-day-old neonate.
authors.affiliation: Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Sunkyung
authors.initials: S
authors.lastname: Jung
authors.forename: Eun-Suk
authors.initials: ES
authors.lastname: Kang
authors.forename: Chang-Seok
authors.initials: CS
authors.lastname: Ki
authors.forename: Dae-Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Kyung-Hoon
authors.initials: KH
authors.lastname: Paik
authors.forename: Yun Sil
authors.initials: YS
authors.lastname: Chang
mesh_terms: D065766:Atypical Hemolytic Uremic Syndrome; D001835:Body Weight; D017242:Complement Factor H / Q000235:genetics; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D009154:Mutation; D010951:Plasma Exchange; D016896:Treatment Outcome
chemical_list: D017242:Complement Factor H