title: Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia.
abstract: A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Schwarz
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Vanda M T
authors.initials: VM
authors.lastname: Stepanek
authors.forename: Tao T
authors.initials: TT
authors.lastname: Le
authors.forename: Vijayashree S
authors.initials: VS
authors.lastname: Bhattar
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Williams
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Wu
authors.forename: Nadarajah
authors.initials: N
authors.lastname: Vigneswaran
authors.forename: Karen
authors.initials: K
authors.lastname: Adler-Storthz
authors.forename: Ann M
authors.initials: AM
authors.lastname: Gillenwater
authors.forename: Rebecca
authors.initials: R
authors.lastname: Richards-Kortum