title: Prospective evaluation of insulin resistance among endometrial cancer patients.
abstract: OBJECTIVE
  Obesity and estrogen are strong risk factors for endometrial cancer (EC). Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). The purpose of this study was to determine the prevalence of IR in newly diagnosed EC patients.
  
  
  METHODS
  EC patients from a large, metropolitan county were prospectively enrolled from 2005 to 2008. Fasting serum was analyzed for glucose and insulin. IR was defined as a history of diabetes or a quantitative insulin sensitivity check index (QUICKI) (1/[log fasting insulin + log fasting glucose]) value of less than 0.357.
  
  
  RESULTS
  Among 99 patients, diabetes was present in 30, and an abnormal QUICKI was found in 36 additional patients. Increased risk of IR was significantly associated with higher body mass index (P < .001), lower socioeconomic status (P = .007), and nulliparity (P = .029).
  
  
  CONCLUSIONS
  IR was highly prevalent in endometrial cancer patients, including nonobese women. Better characterization of metabolic risks in addition to obesity may provide avenues for targeted cancer prevention in the future.
authors.affiliation: Department of Gynecologic Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 70030-4009, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Burzawa
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Schmeler
authors.forename: Pamela T
authors.initials: PT
authors.lastname: Soliman
authors.forename: Larissa A
authors.initials: LA
authors.lastname: Meyer
authors.forename: Michael W
authors.initials: MW
authors.lastname: Bevers
authors.forename: Terri L
authors.initials: TL
authors.lastname: Pustilnik
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Anderson
authors.forename: Lois M
authors.initials: LM
authors.lastname: Ramondetta
authors.forename: Guillermo
authors.initials: G
authors.lastname: Tortolero-Luna
authors.forename: Diana L
authors.initials: DL
authors.lastname: Urbauer
authors.forename: Shine
authors.initials: S
authors.lastname: Chang
authors.forename: David M
authors.initials: DM
authors.lastname: Gershenson
authors.forename: Jubilee
authors.initials: J
authors.lastname: Brown
authors.forename: Karen H
authors.initials: KH
authors.lastname: Lu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000453:epidemiology; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D010298:Parity; D011247:Pregnancy; D011446:Prospective Studies; D044469:Racial Groups; D012044:Regression Analysis; D012923:Social Class