title: A novel three-way Ph variant t(8;9;22) in adult acute lymphoblastic leukemia.
abstract: Although three-way Philadelphia (Ph) variant translocation has been uncommonly (3~8%) reported in chronic myeloid leukemia (CML), it has been even more rarely described in acute leukemias (ALs). When we reviewed the Mitelman database and the literature, we found about 595 three-way Ph variant cases; among these, only 39 three-way Ph variant translocations in AL were documented. Here, we report a novel three-way Ph variant case of t(8;9;22) in adult acute lymphoblastic leukemia (ALL). Based on bone marrow morphology, chromosome fluorescent in situ hybridization (FISH), reverse transcriptase-polymerase chain reaction (RT-PCR), and flow cytometrry, this patient was diagnosed with B lymphoblastic leukemia/lymphoma associated with both t(8;9;22) (q21;q34;q11.2) and BCR/ABL1 rearrangement (e1a2 type). Because of the rarity of reported AL patients with three-way Ph variant, further studies on their prognosis and treatment response to imatinib mesylate are necessary.
authors.affiliation: Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Cho
authors.forename: So Young
authors.initials: SY
authors.lastname: Kim
authors.forename: You La
authors.initials: YL
authors.lastname: Jeon
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Oh
authors.forename: Eun Hae
authors.initials: EH
authors.lastname: Cho
authors.forename: Woo-In
authors.initials: WI
authors.lastname: Lee
authors.forename: Kyung Sam
authors.initials: KS
authors.lastname: Cho
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
mesh_terms: D000328:Adult; D001483:Base Sequence; D001853:Bone Marrow / Q000473:pathology; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism; D015321:Gene Rearrangement; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014178:Translocation, Genetic
chemical_list: D016044:Fusion Proteins, bcr-abl