title: The alleles of theH-13 locus.
abstract: Seven congenic strains differing from C57BL/10Sn at theH-13 locus have been produced which define fourH-13 alleles. Isografting, exchanging of grafts between sublines, F(1) testing, and linkage testing demonstrate the presence of additionalH genes in four of these strains. The medial survival times (MSTs) of skin grafts fromH-13(a) to unimmunizedH-13(b) recipients ranged from 69 to 83 days. Rejection across all other barriers was extremely weak with most MSTs being > 100 days. Preinjection of donor strain thymocytes caused accelerated rejection of skin grafts fromH-13(a) toH-13(b) mice, but had only minimal effect on skin grafts across other barriers. Rejection ofH-13 incompatible grafts was significantly stronger when the donor and host areH-3(a) than when they wereH-3(b).
authors.affiliation: Department of Surgery, Washington University School of Medicine, 63110, St. Louis, Missouri.
authors.forename: R J
authors.initials: RJ
authors.lastname: Graff
authors.forename: D H
authors.initials: DH
authors.lastname: Brown
authors.forename: G D
authors.initials: GD
authors.lastname: Snell