title: Protective effect of Sonchus asper extracts against experimentally induced lung injuries in rats: a novel study.
abstract: In this study, protective effects of methanol extract (SAME) were evaluated against carbon tetrachloride induced oxidative stress in lungs. Male Sprague-Dawley rats were orally fed with various doses (100, 200 mg/kg body weight) of SAME and (50 mg/kg body weight) of rutin after 48 h of CCl(4) treatment (3 ml/kg body weight, 30% in olive oil) biweekly for 4 weeks. The results showed that administration of extracts and rutin significantly restored lung contents of reduced glutathione and activities of catalase, peroxidase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, quinine reductase were reduced while lipid peroxide, hydrogen peroxide, nitrite, DNA fragmentation% and activity of γ-glutamyl transferase, increased by CCl(4), were reversed towards the control levels by the supplement of Sonchus asper extracts and rutin. Lung histopathology showed that S. asper extracts and rutin reduced the incidence of lung lesions induced by CCl(4) in rats. These results suggest that S. asper fractions and rutin could protect lung against the CCl(4)-induced oxidative damage in rats.
authors.affiliation: Department of Biotechnology, University of Science and Technology, Bannu, Khyber Pukhtunkhawa, Pakistan. Rahmatgul_81@yahoo.com
authors.forename: Rahmat Ali
authors.initials: RA
authors.lastname: Khan
authors.forename: Muhammad Rashid
authors.initials: MR
authors.lastname: Khan
authors.forename: Sumaira
authors.initials: S
authors.lastname: Sahreen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000627:therapeutic use*; D002251:Carbon Tetrachloride / Q000633:toxicity; D004249:DNA Damage; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D055370:Lung Injury / Q000139:chemically induced / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D031184:Sonchus / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D002251:Carbon Tetrachloride