title: Draft genome sequences of six Escherichia coli isolates from the stepwise model of emergence of Escherichia coli O157:H7.
abstract: Enterohemorrhagic Escherichia coli (EHEC) of serotype O157:H7 has been implicated in food-borne illnesses worldwide. An evolutionary model was proposed in which the highly pathogenic EHEC O157:H7 serotype arose from its ancestor, enteropathogenic E. coli (EPEC) O55:H7 (sorbitol fermenting [SOR(+)] and β-glucuronidase positive [GUD(+)]), through sequential gain of virulence, phenotypic traits, and serotype change. Here we report six draft genomes of strains belonging to this evolutionary model: two EPEC O55:H7 (SOR(+) GUD(+)) strains, two nonmotile EHEC O157:H(-) strains (SOR(+) GUD(+)) containing plasmid pSFO157, one EHEC O157:H7 (SOR(-) GUD(+)) strain, and one O157:H7 strain containing plasmid pSFO157 (SOR(+) GUD(+)).
authors.affiliation: Division of Microbiology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740. USA.
authors.forename: L V
authors.initials: LV
authors.lastname: Rump
authors.forename: E A
authors.initials: EA
authors.lastname: Strain
authors.forename: G
authors.initials: G
authors.lastname: Cao
authors.forename: M W
authors.initials: MW
authors.lastname: Allard
authors.forename: M
authors.initials: M
authors.lastname: Fischer
authors.forename: E W
authors.initials: EW
authors.lastname: Brown
authors.forename: N
authors.initials: N
authors.lastname: Gonzalez-Escalona
mesh_terms: D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D005517:Foodborne Diseases / Q000382:microbiology; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D010957:Plasmids; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial