title: An unusual cause of carcinoid heart disease.
abstract: Carcinoid heart disease (CHD) is a rare form of valvular heart disease characterized by right-sided heart valve dysfunction. Carcinoid heart disease occurs most frequently when carcinoid tumour cells metastasize from a primary site in the gut to the liver, so that vasoactive substances produced by the tumour are able to reach the systemic circulation. By contrast, in ovarian carcinoid tumours carcinoid heart disease develops in the absence of liver metastasis, because vasoactive substances can be released directly into the systemic circulation, bypassing the first-pass metabolism of the liver. There are only a few case reports in the world literature of carcinoid heart disease caused by ovarian carcinoid tumour. We report a case of an 85-year-old woman with carcinoid heart disease caused by a bilateral ovarian carcinoid tumour metastasized from a primary ileal site.
authors.affiliation: Department of Cardiology, Heilig-Hart Hospital, Roeselare, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Haemers
authors.forename: Karl
authors.initials: K
authors.lastname: Dujardin
mesh_terms: D000369:Aged, 80 and over; D002275:Carcinoid Heart Disease / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000556:secondary*