title: Intranasal localizability of odorants: influence of stimulus volume.
abstract: When an odorant is presented to one side of the nose and air to the other, the ability to localize which side received the odorant depends upon trigeminal nerve stimulation. It has been shown that performance on this lateralization task increases as stimulus concentration increases. In this study, we determined the influences of stimulus volume and sex on the ability to localize each of 8 odorants presented at neat concentrations: anethole, geraniol, limonene, linalool, menthol, methyl salicylate, phenyl ethanol, and vanillin. At a low stimulus volume (11 mL), only menthol was localized at an above-chance level. At a high stimulus volume (21 mL), above-chance localization occurred for all odorants except vanillin. Women were significantly better than men in localizing menthol. Stimuli rated as most intense were those that were most readily localized. The detection performance measures, as well as rated intensity values, significantly correlated with earlier findings of the trigeminal detectability of odorants presented to anosmic and normosmic subjects. This study suggests that differences in stimulus volume may explain some discrepant findings within the trigeminal chemosensory literature and supports the concept that vanillin may be a "relatively pure" olfactory stimulus.
authors.affiliation: Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, Dresden, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Frasnelli
authors.forename: T
authors.initials: T
authors.lastname: Hummel
authors.forename: J
authors.initials: J
authors.lastname: Berg
authors.forename: G
authors.initials: G
authors.lastname: Huang
authors.forename: R L
authors.initials: RL
authors.lastname: Doty
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D009812:Odorants / Q000032:analysis; D012737:Sex Factors; D012903:Smell; D014276:Trigeminal Nerve / Q000378:metabolism; D055815:Young Adult