title: Anti-Saccharomyces cerevisiae (ASCA) and anti-endomysial antibodies in spondyloarthritis.
abstract: Spondyloarthritis (SpA) are diseases with increased gut inflammation. To search for (anti-Saccharomyces cerevisiae) ASCA IgA, ASCA IgG, and anti-endomysial antibodies (EmA-IgA) in a cohort of 70 patients with SpA, we found 18.6% (13/70) positive for IgA-ASCA in the SpA group and 3/57 (5.2%) in the control group (P = 0.031). ASCA IgG and EmA-IgA were found at the same frequency in SpA and controls. No relationship of ASCA IgA positivity could be established with disease activity (measured by ESR, C-reactive protein, and BASDAI), presence of uveitis, or peripheral arthritis neither with functional status measured by BASFI. SpA patients present an increase in the IgA-ASCA positivity without any relationship to disease activity, functional index, clinical profile or the presence of HLA-B27. There is no evidence of higher prevalence of EmA-IgA in SpA patients in the studied sample.
authors.affiliation: Evangelic University Hospital, Rheumatology Unit, Rua João Alencar Guimarães, 796, Curitiba, PR 80 310420, Brazil.
authors.forename: Marianne A
authors.initials: MA
authors.lastname: Andretta
authors.forename: Thaís D
authors.initials: TD
authors.lastname: Vieira
authors.forename: Renato
authors.initials: R
authors.lastname: Nishiara
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
mesh_terms: D000328:Adult; D000908:Antibodies, Fungal / Q000096:biosynthesis*; D001323:Autoantibodies / Q000096:biosynthesis*; D002446:Celiac Disease / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000276:immunology*; D015995:Prevalence; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D013167:Spondylitis, Ankylosing / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D055815:Young Adult
chemical_list: D000908:Antibodies, Fungal; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G