title: A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery.
abstract: We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.
authors.affiliation: Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea.
authors.forename: Bo Reum
authors.initials: BR
authors.lastname: Lee
authors.forename: Kyung Taek
authors.initials: KT
authors.lastname: Oh
authors.forename: Young Taik
authors.initials: YT
authors.lastname: Oh
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Baik
authors.forename: So Young
authors.initials: SY
authors.lastname: Park
authors.forename: Yu Seok
authors.initials: YS
authors.lastname: Youn
authors.forename: Eun Seong
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008298:Maleates / Q000737:chemistry*; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D010455:Peptides / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008298:Maleates; D010455:Peptides; C118638:glycol-chitosan; D048271:Chitosan; C004780:dimethyl maleate