title: Resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes.
abstract: Chronic hyperglycemia increases oxidative stress status and has been associated with neurological complications in diabetic individuals. This study compared the antioxidant properties of red wine or resveratrol in different brain areas of diabetic and non-diabetic rats, and investigated the effect of them on hippocampal cell proliferation in hippocampal dentate gyrus of diabetic rats. Streptozotocin-induced diabetic and control rats were treated with red wine (4 mL/kg), resveratrol (20 mg/kg), or saline, by oral gavage, for 21 days. Lipid peroxidation (TBARS), catalase and superoxide dismutase were measured to evaluate the oxidative stress and the BrdU-positive cells were assessed to measure changes in cellular proliferation. In diabetic animals, resveratrol showed antioxidant property in the hippocampus and in the striatum, while red wine had an antioxidant effect only in the hippocampus. Neither red wine nor resveratrol reversed the lower hippocampal cell proliferation in diabetic rats. Daily doses of red wine or resveratrol have an antioxidant effect in rats depending on the brain area and the glycemic status.
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre, Division of Pharmacology, Porto Alegre, Brazil.
authors.forename: Carina Duarte
authors.initials: CD
authors.lastname: Venturini
authors.forename: Suélen
authors.initials: S
authors.lastname: Merlo
authors.forename: André Arigony
authors.initials: AA
authors.lastname: Souto
authors.forename: Marilda da Cruz
authors.initials: Mda C
authors.lastname: Fernandes
authors.forename: Rosane
authors.initials: R
authors.lastname: Gomez
authors.forename: Claudia Ramos
authors.initials: CR
authors.lastname: Rhoden
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D015227:Lipid Peroxidation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014920:Wine
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D002374:Catalase; D013482:Superoxide Dismutase; D000077185:Resveratrol