title: Malignant vaginal melanoma with metastases to the papilla of Vater in a dialysis patient: a case report.
abstract: Malignant vaginal melanoma is an extremely rare clinical condition, with less than 150 cases reported to date. A dialysis patient had primary vaginal melanoma with metastases to the papilla of Vater. Gastroduodenoscopy revealed a polypoid tumor. Histological findings revealed vimentin, S-100 protein, HMB45, MelanA-positive sarcoma-like cells. This staining pattern indicated that this tumor was a malignant melanoma of the papilla. Analysis of an autopsy specimen of the papilla of Vater revealed metastasis from the primary vaginal melanoma. Metastasis of a malignant tumor to the gastrointestinal tract, especially to the papilla, is uncommon. Melanoma should be considered in the differential diagnosis of primary gastrointestinal tract malignancy.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Shinrakuen Hospital, Japan. hitoshin@qk9.so-net.ne.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakayama
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Saito
authors.forename: Hisaki
authors.initials: H
authors.lastname: Shimada
authors.forename: Shinji
authors.initials: S
authors.lastname: Sakai
authors.forename: Masashi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kakuhei
authors.initials: K
authors.lastname: Kimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000473:pathology; D003138:Common Bile Duct Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008545:Melanoma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D006435:Renal Dialysis; D014625:Vaginal Neoplasms / Q000150:complications / Q000473:pathology