title: Functional polymorphism -31C/G in the promoter of BIRC5 gene and risk of nasopharyngeal carcinoma among chinese.
abstract: BACKGROUND
  Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin) is a member of the inhibitor of apoptosis protein (IAP) family, which plays an important role in the occurrence and progression of cancer. Recently, a polymorphism in the promoter of BIRC5, -31C/G (rs9904341), was shown to influence BIRC5 expression.
  
  
  METHODS
  We examined whether the -31C/G was related to the risk of developing nasopharyngeal carcinoma (NPC) in a case-control population from Guangxi province in southern China, which consists of 855 patients with NPC and 1036 controls. This polymorphism was genotyped by TaqMan assay. The genetic associations with the occurrence and progression of NPC were estimated by logistic regression.
  
  
  RESULTS
  We observed a statistically significant increased occurrence of NPC associated with the CC genotype (odds ratio [OR], 1.40; 95% confidence interval [CI], 1.13-1.73; P=0.0020) compared with the genotypes containing G allele (CG + GG genotype). However, no significant association was observed for the -31C/G with the severity of NPC (as measured by tumor-node-metastasis staging system).
  
  
  CONCLUSIONS
  Our findings suggest that the functional polymorphism -31C/G in the promoter of BIRC5 gene may play a role in mediating the susceptibility to NPC among Chinese.
authors.affiliation: State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.
authors.forename: Fuchao
authors.initials: F
authors.lastname: Ma
authors.forename: Hongxing
authors.initials: H
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhai
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Huang
authors.forename: Chang
authors.initials: C
authors.lastname: Zhao
authors.forename: Shengqiu
authors.initials: S
authors.lastname: Ou
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Yuan
authors.forename: Zhifu
authors.initials: Z
authors.lastname: Wang
authors.forename: Hongxue
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Yue
authors.forename: Lixia
authors.initials: L
authors.lastname: Yu
authors.forename: Peiyao
authors.initials: P
authors.lastname: Li
authors.forename: Xia
authors.initials: X
authors.lastname: Xia
authors.forename: Mi
authors.initials: M
authors.lastname: Cai
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Cui
authors.forename: Fuchu
authors.initials: F
authors.lastname: He
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.forename: Gangqiao
authors.initials: G
authors.lastname: Zhou
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002277:Carcinoma; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D009362:Neoplasm Metastasis; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin