title: A core-shell nanomaterial with endogenous therapeutic and diagnostic functions.
abstract: In the present communication we report the fabrication a unique core-shell inorganic nanomaterial with potential therapeutic and diagnostic functions. It contains an iron-cobalt (FeCo) core that demonstrates MRI contrast property and a thin nanoshell of gold that inhibits the function of a pro-angiogenic growth factor, VEGF165. Au(FeCo) core-shell nanomaterials are fabricated in the gas phase and characterized using transmission electron microscopy (TEM), energy dispersive spectrum (EDS), inductively coupled plasma analysis (ICP) and magnetic resonance imaging (MRI). Inhibition of VEGF165 function by Au(FeCo) is demonstrated against VEGF165/VPF induced signaling cascades and proliferation of HUVECs. Self-contrast property of Au(FeCo) is determined in vitro by MRI after incubating HUVECs with Au(FeCo), demonstrating intrinsic contrast property of this potentially therapeutic nanomaterial. In brief, we report here the successful fabrication of an inorganic core-shell nanomaterials with potential therapeutic and diagnostic functions. It inhibits the function of VEGF165 and function as a MRI contrast agent.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Chitta Ranjan
authors.initials: CR
authors.lastname: Patra
authors.forename: Ying
authors.initials: Y
authors.lastname: Jing
authors.forename: Yun-Hao
authors.initials: YH
authors.lastname: Xu
authors.forename: Resham
authors.initials: R
authors.lastname: Bhattacharya
authors.forename: Debabrata
authors.initials: D
authors.lastname: Mukhopadhyay
authors.forename: James F
authors.initials: JF
authors.lastname: Glockner
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Wang
authors.forename: Priyabrata
authors.initials: P
authors.lastname: Mukherjee