title: Expression of CD1d protein in human testis showing normal and abnormal spermatogenesis.
abstract: CD1d is a member of CD1 family of transmembrane glycoproteins, which represent antigen-presenting molecules. Immunofluorescent staining methods were utilized to examine expression pattern of CD1d in human testicular specimens. In testis showing normal spermatogenesis, a strong CD1d cytoplasmic expression was seen the Sertoli cells, spermatogonia, and Leydig cells. A moderate expression was observed in the spermatocytes. In testes showing maturation arrest, CD1d expression was strong in the Sertoli cells and weak in spermatogonia and spermatocytes compared to testis with normal spermatogenesis. In Sertoli cell only syndrome, CD1d expression was strong in the Sertoli and Leydig cells. This preliminary study displayed testicular infertility-related changes in CD1d expression. The ultrastructural changes associated with with normal and abnormal spermatogenesis are open for further investigations.
authors.affiliation: Department of Zoology, Faculty of Science, Sohag University, Sohag, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Adly
authors.forename: Mahmoud-Rezk
authors.initials: MR
authors.lastname: Abdelwahed Hussein
mesh_terms: D055610:Antigens, CD1d / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D006801:Humans; D007124:Immunoenzyme Techniques; D007248:Infertility, Male / Q000473:pathology; D008297:Male; D012708:Sertoli Cells / Q000378:metabolism / Q000473:pathology; D013090:Spermatocytes / Q000378:metabolism / Q000473:pathology; D013091:Spermatogenesis / Q000502:physiology*; D013093:Spermatogonia / Q000378:metabolism / Q000473:pathology; D013737:Testis / Q000378:metabolism* / Q000473:pathology
chemical_list: D055610:Antigens, CD1d; D015415:Biomarkers; C526877:CD1D protein, human