title: State of the art in the endoscopic imaging and ablation of Barrett's esophagus.
abstract: Barrett's esophagus is the result of long-term acid reflux and is a precursor to esophageal adenocarcinoma. Surgical resection of the esophagus has been the mainstay of treatment for high grade dysplasia and early cancer. However, recent advances in the endoscopic imaging and ablation technologies have made esophagectomy avoidable in patients with dysplasia and superficial neoplasia. In this article, we review the most relevant endoscopic imaging technologies, such as chromoendoscopy, narrow band and autofluorescence imaging, and confocal laser endomicroscopy. We also review the various endoscopic ablation technologies, such as endoscopic mucosal resection, photodynamic therapy, radiofrequency ablation, and cryotherapy. Finally, we focus on the studies that evaluate the efficacy of these imaging and ablation technologies in finding and eradicating neoplastic Barrett's esophagus.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, United States.
authors.forename: Abraham M
authors.initials: AM
authors.lastname: Panossian
authors.forename: Massimo
authors.initials: M
authors.lastname: Raimondo
authors.forename: Herbert C
authors.initials: HC
authors.lastname: Wolfsen
mesh_terms: D001471:Barrett Esophagus / Q000175:diagnosis* / Q000628:therapy*; D017115:Catheter Ablation; D003452:Cryosurgery; D004210:Dissection; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008679:Metaplasia / Q000175:diagnosis; D009092:Mucous Membrane / Q000601:surgery; D010778:Photochemotherapy