title: Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis.
abstract: Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.
authors.affiliation: Department of Cell Biology, Okayama University Graduate, School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.forename: Ken
authors.initials: K
authors.lastname: Kataoka
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Fernando
authors.initials: F
authors.lastname: Abarzua
authors.forename: Swe Swe
authors.initials: SS
authors.lastname: Than
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sonegawa
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Makino
authors.forename: Tadamichi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Nam-Ho
authors.initials: NH
authors.lastname: Huh
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D045744:Cell Line, Tumor; D018925:Chemokines; D015536:Down-Regulation / Q000502:physiology; D004622:Embryo, Mammalian / Q000378:metabolism; D004817:Epidermis / Q000196:embryology / Q000378:metabolism*; D018859:Hair Follicle / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007642:Keratosis / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017444:Skin Diseases, Papulosquamous / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014945:Wound Healing / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018925:Chemokines; C498624:DKK3 protein, human; C405061:Dkk3 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D013755:Tetradecanoylphorbol Acetate