title: Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice.
abstract: Metabolic dysregulation (e.g., hyperglycemia, hyperinsulinemia, hyperlipidemia, etc.) is a hallmark of obesity-related diseases such as insulin resistance, type 2 diabetes, and fatty liver disease. In this study, we assessed whether dietary capsaicin attenuated the metabolic dysregulation in genetically obese diabetic KKAy mice, which have severe diabetic phenotypes. Male KKAy mice fed a high-fat diet for 2 weeks received a 0.015% capsaicin supplement for a further 3 weeks and were compared with nonsupplemented controls. Dietary capsaicin markedly decreased fasting glucose/insulin and triglyceride levels in the plasma and/or liver, as well as expression of inflammatory adipocytokine genes (e.g., monocyte chemoattractant protein-1 and interleukin-6) and macrophage infiltration. At the same time expression of the adiponectin gene/protein and its receptor, AdipoR2, increased in adipose tissue and/or plasma, accompanied by increased activation of hepatic AMP-activated protein kinase, a marker of fatty acid oxidation. These findings suggest that dietary capsaicin reduces metabolic dysregulation in obese/diabetic KKAy mice by enhancing expression of adiponectin and its receptor. Capsaicin may be useful as a dietary factor for reducing obesity-related metabolic dysregulation.
authors.affiliation: Department of Food Science and Nutrition, University of Ulsan, Nam-ku, Ulsan, Republic of Korea.
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Kang
authors.forename: Goto
authors.initials: G
authors.lastname: Tsuyoshi
authors.forename: Hoan
authors.initials: H
authors.lastname: Le Ngoc
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Thai Hien
authors.initials: TH
authors.lastname: Tu
authors.forename: Hye-Ji
authors.initials: HJ
authors.lastname: Noh
authors.forename: Chu-Sook
authors.initials: CS
authors.lastname: Kim
authors.forename: Suck-Young
authors.initials: SY
authors.lastname: Choe
authors.forename: Teruo
authors.initials: T
authors.lastname: Kawada
authors.forename: Hoon
authors.initials: H
authors.lastname: Yoo
authors.forename: Rina
authors.initials: R
authors.lastname: Yu
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D054392:Adipokines / Q000378:metabolism; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002211:Capsaicin / Q000494:pharmacology / Q000627:therapeutic use*; D002212:Capsicum / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D019587:Dietary Supplements; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D054419:Receptors, Adiponectin / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D054419:Receptors, Adiponectin; D014280:Triglycerides; C475421:adiponectin receptor 2, mouse; D055372:AMP-Activated Protein Kinases; D002211:Capsaicin