title: The design and cytotoxic evaluation of some 1-aryl-3-isopropylamino-1-propanone hydrochlorides towards human Huh-7 hepatoma cells.
abstract: A series of 1-aryl-3-isopropylamino-1-propanone hydrochlorides 1 and a related heterocyclic analog 2 as candidate antineoplastic agents were prepared and the rationale for designing these compounds is presented. A specific objective in this study is the discovery of novel compounds possessing growth-inhibiting properties of hepatoma cells. The compounds in series 1 and 2 were prepared and their structures established unequivocally. X-ray crystallography of two representative compounds 1d and 1g were achieved. Over half of the compounds are more potent than 5-fluorouracil which is an established drug used in treating liver cancers. QSAR evaluations and molecular modeling studies were undertaken with a view to detecting some physicochemical parameters which govern cytotoxic potencies. A number of guidelines for amplification of the project have been formulated.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Ataturk University, Erzurum, Turkey. ebru25@atauni.edu.tr
authors.forename: Ebru
authors.initials: E
authors.lastname: Mete
authors.forename: H Inci
authors.initials: HI
authors.lastname: Gul
authors.forename: Rengul
authors.initials: R
authors.lastname: Cetin-Atalay
authors.forename: Umashankar
authors.initials: U
authors.lastname: Das
authors.forename: Ertan
authors.initials: E
authors.lastname: Sahin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gul
authors.forename: Cavit
authors.initials: C
authors.lastname: Kazaz
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dimmock
mesh_terms: D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms; D008958:Models, Molecular; D011437:Propylamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011437:Propylamines; D000096:Acetone; D005472:Fluorouracil