title: Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds.
abstract: A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N -[(1-Oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-4yl)methyl]-9H-fluoren-2-amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells.
authors.affiliation: Institute of Organic and Medicinal Chemistry, University of Pécs, Szigeti st 12, H-7624 Pécs, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Kálai
authors.forename: Jitka
authors.initials: J
authors.lastname: Petrlova
authors.forename: Mária
authors.initials: M
authors.lastname: Balog
authors.forename: Hnin Hnin
authors.initials: HH
authors.lastname: Aung
authors.forename: John C
authors.initials: JC
authors.lastname: Voss
authors.forename: Kálmán
authors.initials: K
authors.lastname: Hideg
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D002460:Cell Line; D004578:Electron Spin Resonance Spectroscopy; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D008066:Lipolysis / Q000187:drug effects; D009589:Nitrogen Oxides / Q000737:chemistry*; D010545:Peroxides / Q000737:chemistry; D055503:Protein Multimerization / Q000187:drug effects*; D017433:Protein Structure, Secondary
chemical_list: D000682:Amyloid; D005449:Fluorenes; D016166:Free Radical Scavengers; D009589:Nitrogen Oxides; D010545:Peroxides; C049375:perhydroxyl radical; D017665:Hydroxyl Radical; C039900:nitroxyl