title: Non-steroidal and steroidal anti-inflammatory use in the context of orthodontic movement.
abstract: The early phase of orthodontic tooth movement involves sterile acute inflammation of the periodontal ligament in response to biomechanical forces. Anti-inflammatories are pharmacologic agents used in medical and dentistry clinics. The aim of the study was to analyse the bone remodelling during orthodontic movement under non-steroidal and steroidal treatment. Male Wistar rats (n = 90) were randomly divided into three groups: C (control), non-steroidal anti-inflammatory drug (NSAID; potassium diclofenac), and steroidal anti-inflammatory drug (SAID; dexamethasone dissodium phosphate). The animals of the C group received 0.9 per cent saline solution, the NSAID group received potassium diclofenac CATAFLAM® (5 mg/kg), and the SAID group received dexamethasone dissodium phosphate DEXANIL® (2 mg/kg). Animals were sacrificed 3, 7, or 14 days after placement of the orthodontic appliance. The upper first molars were processed histologically; we quantified the blood vessels, Howship lacunae, and osteoclast-like cells present on the tension and compression sides of the periodontal ligament. Bone formation was evaluated under polarized light microscopy; 4.5 Image Pro-Plus® software calculated the percentage of immature/mature collagen present. The results showed that, in 3 and 7 days, NSAID and SAID groups presented fewer blood vessels, Howship lacunae, and osteoclast-like cells when compared to the control group. On the 7th and 14th days, there was a lower percentage of mature collagen in the SAID group (P < 0.001). These data demonstrate that potassium diclofenac and dexamethasone inhibit bone resorption during the initial period of orthodontic movement and that dexamethasone delays the collagen maturation process in established bone matrix.
authors.affiliation: Department of Orthodontics, Pontifical Catholic University of Paraná, Curitiba, Brazil.
authors.forename: Luégya Amorim Henriques
authors.initials: LA
authors.lastname: Knop
authors.forename: Ricardo Lima
authors.initials: RL
authors.lastname: Shintcovsk
authors.forename: Luciana Borges
authors.initials: LB
authors.lastname: Retamoso
authors.forename: Jucienne Salgado
authors.initials: JS
authors.lastname: Ribeiro
authors.forename: Orlando Motohiro
authors.initials: OM
authors.lastname: Tanaka
mesh_terms: D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects* / Q000502:physiology; D003094:Collagen / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D008297:Male; D008859:Microscopy, Polarization; D010513:Periodontal Ligament / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
chemical_list: D000893:Anti-Inflammatory Agents; D004008:Diclofenac; D003907:Dexamethasone; D003094:Collagen