title: How and why does the proteome respond to microgravity?
abstract: For medical and biotechnological reasons, it is important to study mammalian cells, animals, bacteria and plants exposed to simulated and real microgravity. It is necessary to detect the cellular changes that cause the medical problems often observed in astronauts, cosmonauts or animals returning from prolonged space missions. In order for in vitro tissue engineering under microgravity conditions to succeed, the features of the cell that change need to be known. In this article, we summarize current knowledge about the effects of microgravity on the proteome in different cell types. Many studies suggest that the effects of microgravity on major cell functions depend on the responding cell type. Here, we discuss and speculate how and why the proteome responds to microgravity, focusing on proteomic discoveries and their future potential.
authors.affiliation: Department of Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK-8000 Århus C, Denmark. daniela.grimm@farm.au.dk
authors.forename: Daniela
authors.initials: D
authors.lastname: Grimm
authors.forename: Petra
authors.initials: P
authors.lastname: Wise
authors.forename: Michael
authors.initials: M
authors.lastname: Lebert
authors.forename: Peter
authors.initials: P
authors.lastname: Richter
authors.forename: Sarah
authors.initials: S
authors.lastname: Baatout
mesh_terms: D000818:Animals; D018480:Astronauts; D001419:Bacteria / Q000254:growth & development; D002460:Cell Line; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D063245:Plant Development; D020543:Proteome / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D018561:Space Simulation; D014893:Weightlessness
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D020543:Proteome