title: IgLONs form heterodimeric complexes on forebrain neurons.
abstract: IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth and synaptogenesis and may act as tumour suppressor genes. Recently we have proposed that two members of the IgLON family act as a heterodimeric complex termed DIgLON. Neurons isolated from chick forebrain co-express all six combinations of IgLONs and the intensity of fluorescence for each pair of IgLONs was highly correlated. Antibody-patching experiments on forebrain neurons show complex formation for IgLON pairs but not between unrelated GPI-anchored glycoproteins. Thus IgLONs are the first GPI-anchored family of glycoproteins shown to form heterodimeric complexes in the plane of the membrane.
authors.affiliation: Department of Human Anatomy and Cell Biology, Liverpool University, UK.
authors.forename: Christine J
authors.initials: CJ
authors.lastname: McNamee
authors.forename: Sahar
authors.initials: S
authors.lastname: Youssef
authors.forename: Diana
authors.initials: D
authors.lastname: Moss
mesh_terms: D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry / Q000378:metabolism*; D002645:Chickens; D019281:Dimerization; D018507:Gene Expression Regulation, Developmental; D005810:Multigene Family; D009474:Neurons / Q000737:chemistry / Q000378:metabolism*; D016548:Prosencephalon / Q000737:chemistry / Q000196:embryology / Q000378:metabolism*
chemical_list: D015816:Cell Adhesion Molecules, Neuronal