title: Generation of comprehensive thoracic oncology database--tool for translational research.
abstract: The Thoracic Oncology Program Database Project was created to serve as a comprehensive, verified, and accessible repository for well-annotated cancer specimens and clinical data to be available to researchers within the Thoracic Oncology Research Program. This database also captures a large volume of genomic and proteomic data obtained from various tumor tissue studies. A team of clinical and basic science researchers, a biostatistician, and a bioinformatics expert was convened to design the database. Variables of interest were clearly defined and their descriptions were written within a standard operating manual to ensure consistency of data annotation. Using a protocol for prospective tissue banking and another protocol for retrospective banking, tumor and normal tissue samples from patients consented to these protocols were collected. Clinical information such as demographics, cancer characterization, and treatment plans for these patients were abstracted and entered into an Access database. Proteomic and genomic data have been included in the database and have been linked to clinical information for patients described within the database. The data from each table were linked using the relationships function in Microsoft Access to allow the database manager to connect clinical and laboratory information during a query. The queried data can then be exported for statistical analysis and hypothesis generation.
authors.affiliation: Pritzker School of Medicine, Department of Medicine, University of Chicago, Chicago, USA.
authors.forename: Mosmi
authors.initials: M
authors.lastname: Surati
authors.forename: Matthew
authors.initials: M
authors.lastname: Robinson
authors.forename: Suvobroto
authors.initials: S
authors.lastname: Nandi
authors.forename: Leonardo
authors.initials: L
authors.lastname: Faoro
authors.forename: Carley
authors.initials: C
authors.lastname: Demchuk
authors.forename: Rajani
authors.initials: R
authors.lastname: Kanteti
authors.forename: Benjamin
authors.initials: B
authors.lastname: Ferguson
authors.forename: Tara
authors.initials: T
authors.lastname: Gangadhar
authors.forename: Thomas
authors.initials: T
authors.lastname: Hensing
authors.forename: Rifat
authors.initials: R
authors.lastname: Hasina
authors.forename: Aliya
authors.initials: A
authors.lastname: Husain
authors.forename: Mark
authors.initials: M
authors.lastname: Ferguson
authors.forename: Theodore
authors.initials: T
authors.lastname: Karrison
authors.forename: Ravi
authors.initials: R
authors.lastname: Salgia
mesh_terms: D016208:Databases, Factual; D006801:Humans; D008495:Medical Oncology / Q000379:methods*; D013899:Thoracic Neoplasms; D014015:Tissue Banks; D057170:Translational Research, Biomedical / Q000379:methods*