title: The steroidogenic factor-1 protein is not expressed in various forms of endometriosis but is strongly present in ovarian cortical or medullary mesenchymatous cells adjacent to endometriotic foci.
abstract: Steroidogenic factor-1 (SF-1) protein expression was not observed in any form of endometriosis (peritoneal, ovarian, or deep infiltrating endometriosis), which suggests that SF-1 locally produced by endometrial or stromal cells may not play a major role in the development of endometriosis. However, the strong expression of SF-1 in cortical and medullary ovarian mesenchymatous cells may be capable of creating a favorable steroidogenic environment and the development of the disease.
authors.affiliation: Department of Gynecopathology, Erasme University Hospital, Free University of Brussels, Brussels, Belgium. Jean-Christophe.Noel@erasme.ulb.ac.be
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Noël
authors.forename: Vincent
authors.initials: V
authors.lastname: Anaf
authors.forename: Bruno
authors.initials: B
authors.lastname: Borghese
authors.forename: Daniel
authors.initials: D
authors.lastname: Vaiman
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fayt
authors.forename: Charles
authors.initials: C
authors.lastname: Chapron
mesh_terms: D001706:Biopsy; D016022:Case-Control Studies; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008648:Mesoderm / Q000737:chemistry* / Q000473:pathology; D010049:Ovarian Diseases / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000737:chemistry* / Q000473:pathology; D010532:Peritoneal Diseases / Q000378:metabolism* / Q000473:pathology; D054339:Steroidogenic Factor 1 / Q000032:analysis*; D017154:Stromal Cells / Q000737:chemistry* / Q000473:pathology
chemical_list: C515057:NR5A1 protein, human; D054339:Steroidogenic Factor 1