title: Modelling the prevalence of age-related macular degeneration (2010-2020) in the UK: expected impact of anti-vascular endothelial growth factor (VEGF) therapy.
abstract: OBJECTIVE
  To project the number of cases with age-related macular degeneration (AMD) and the numbers with attributable sight loss in the UK in 2010-2020, taking into account the expected beneficial effect of the new anti-vascular endothelial growth factor (VEGF) therapies.
  
  
  METHODS
  A 'system dynamics' approach was used in constructing the model to simulate the dynamics of the disease in large populations. The model computed the pool of affected cases over the simulation period, taking into account the expected demographic changes. Other determinants taken into account included: prevalence; incidence; mortality; and the expected efficacy and coverage of anti-VEGF treatment.
  
  
  RESULTS
  In the UK, 608,213 persons in 2010 are estimated to have AMD, and this is expected to increase to 755,867 by the end of the decade. Numbers with sight loss from AMD are expected to rise from 223,224 in 2010 to 291,982 by 2020. Cases with sight loss due to neovascular AMD are expected to increase from 145,697 to 189,890 by the end of the decade.
  
  
  CONCLUSIONS
  The model predicts that the beneficial effects of the treatment would be outweighed by the strong anticipated demographic 'ageing' effect. This reaffirms the importance of continuing efforts to develop more effective and more broadly applicable therapies for AMD.
authors.affiliation: Division of Epidemiology & Genetics, Institute of Ophthalmology, UCL, London, UK. d.minassian@ucl.ac.uk
authors.forename: Darwin C
authors.initials: DC
authors.lastname: Minassian
authors.forename: Angela
authors.initials: A
authors.lastname: Reidy
authors.forename: Anita
authors.initials: A
authors.lastname: Lightstone
authors.forename: Parul
authors.initials: P
authors.lastname: Desai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D001766:Blindness / Q000453:epidemiology; D057092:Geographic Atrophy / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D015233:Models, Statistical; D015995:Prevalence; D006113:United Kingdom / Q000453:epidemiology; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D014792:Visual Acuity; D057135:Wet Macular Degeneration / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A