title: Measles virotherapy in a mouse model of adult T-cell leukaemia/lymphoma.
abstract: Adult T-cell leukaemia/lymphoma (ATL) is a highly aggressive CD4(+) T-cell malignancy caused by human T-cell leukaemia virus type 1. Measles virus (MV) oncolytic therapy has been reported to be efficient in reducing tumour burden in subcutaneous xenograft models of lymphoproliferative disorders such as myeloma, B-cell lymphoma and cutaneous T-cell lymphoma, but its potential to reduce tumour burden in disseminated lymphoproliferative disorders such as ATL remains to be determined. In this study, MV oncolytic therapy was evaluated in the MET-1/NOD/SCID xenograft mouse model of ATL. Treatment with the vaccine-related strain MV-NSE led to a significant reduction in tumour burden. In mice with a high tumour burden, therapy with MV-NSE significantly increased survival beyond any other single treatment tested previously using this model. Interestingly, signs of morbidity (cachexia) in mice treated with MV were not directly associated with tumour burden, but were correlated with the secretion of interleukin-6 by MET-1 cells and host cells. The results suggest that MV therapy could be a promising therapy for generalized lymphoproliferative disease.
authors.affiliation: Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Parrula
authors.affiliation: Comprehensive Cancer Center, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio, USA.|Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Soledad A
authors.initials: SA
authors.lastname: Fernandez
authors.affiliation: Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Bevin
authors.initials: B
authors.lastname: Zimmerman
authors.affiliation: Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.|Comprehensive Cancer Center, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio, USA.|Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Lairmore
authors.affiliation: Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA.|Comprehensive Cancer Center, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio, USA.|Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: Niewiesk
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology / Q000401:mortality / Q000628:therapy* / Q000821:virology; D008459:Measles virus / Q000235:genetics / Q000502:physiology*; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000235:genetics / Q000502:physiology*