title: Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study.
abstract: OBJECTIVE
  Genetic variability in the NR1H3 gene (encoding LXRα) and in several of its target genes is associated with serum HDL-cholesterol (HDL-C) concentrations. We sought to assess if these associations could be detected in adolescents.
  
  
  METHODS
  Thirty-nine polymorphisms in NR1H3, ABCA1, APOE, CETP, PLTP and LPL were analysed in the HELENA study (n = 1144 European adolescents).
  
  
  RESULTS
  The minor alleles of rs11039155 in NR1H3, rs2575879 in ABCA1, rs708272, rs17231506 and rs5882 in CETP and rs328 in LPL were associated with higher serum HDL-C concentrations (p ≤ 0.0012). The minor alleles of rs12221497 in NR1H3, rs1800978 in ABCA1 and the APOE ɛ4 allele were associated with lower HDL-C concentrations (p ≤ 0.01). The combined set of associated polymorphisms accounted for ∼6.6% of the variance in HDL-C.
  
  
  CONCLUSIONS
  We report for the first time that polymorphisms in NR1H3 and its target genes ABCA1, APOE, CETP and LPL contribute to the genetic variance for HDL-C concentrations in adolescence.
authors.affiliation: INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France, UDSL, Lille, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Legry
authors.forename: Szilvia
authors.initials: S
authors.lastname: Bokor
authors.forename: Laurent
authors.initials: L
authors.lastname: Beghin
authors.forename: Myriam
authors.initials: M
authors.lastname: Galfo
authors.forename: Marcela
authors.initials: M
authors.lastname: Gonzalez-Gross
authors.forename: Denes
authors.initials: D
authors.lastname: Molnar
authors.forename: Luis A
authors.initials: LA
authors.lastname: Moreno
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Jean
authors.initials: J
authors.lastname: Dallongeville
authors.forename: Aline
authors.initials: A
authors.lastname: Meirhaeghe
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000293:Adolescent; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005060:Europe; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008071:Lipoprotein Lipase / Q000235:genetics; D000071518:Liver X Receptors; D008297:Male; D057093:Orphan Nuclear Receptors / Q000235:genetics*; D010641:Phenotype; D049294:Phospholipid Transfer Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D001057:Apolipoproteins E; D015415:Biomarkers; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors; C493430:PLTP protein, human; D049294:Phospholipid Transfer Proteins; C548261:LPL protein, human; D008071:Lipoprotein Lipase