title: Metabolic robustness and network modularity: a model study.
abstract: BACKGROUND
  Several studies have mentioned network modularity-that a network can easily be decomposed into subgraphs that are densely connected within and weakly connected between each other-as a factor affecting metabolic robustness. In this paper we measure the relation between network modularity and several aspects of robustness directly in a model system of metabolism.
  
  
  RESULTS
  By using a model for generating chemical reaction systems where one can tune the network modularity, we find that robustness increases with modularity for changes in the concentrations of metabolites, whereas it decreases with changes in the expression of enzymes. The same modularity scaling is true for the speed of relaxation after the perturbations.
  
  
  CONCLUSIONS
  Modularity is not a general principle for making metabolism either more or less robust; this question needs to be addressed specifically for different types of perturbations of the system.
authors.affiliation: Department of Physics, Umeå University, Umeå, Sweden. petter.holme@physics.umu.se
authors.forename: Petter
authors.initials: P
authors.lastname: Holme
mesh_terms: D004526:Efficiency; D004790:Enzyme Induction / Q000235:genetics / Q000502:physiology; D004798:Enzymes / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D053263:Gene Regulatory Networks / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008659:Metabolic Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D053858:Metabolic Networks and Pathways / Q000235:genetics / Q000502:physiology*; D008660:Metabolism / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D008962:Models, Theoretical; D009994:Osmolar Concentration; D013379:Substrate Specificity / Q000235:genetics / Q000502:physiology
chemical_list: D004798:Enzymes