title: Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men.
abstract: The JAK/STAT signaling pathway is essential for myogenic regeneration and is regulated by a diverse range of ligands, including interleukin-6 (IL-6) and platelet-derived growth factor-BB (PDGF-BB). Our aim was to evaluate the responsiveness of IL-6 and PDGF-BB to intense exercise, along with STAT3 activation, before and after 12 weeks of resistance training. In young men, IL-6 and PDGF-BB protein concentrations were quantified in biopsied muscle and increased at 3 h post-exercise (17.5-fold and 3-fold, respectively). The response was unaltered by 12 weeks of training. Similarly, STAT3 phosphorylation was elevated post-exercise (12.5-fold), irrespective of training status, as was the expression of downstream targets c-MYC (8-fold), c-FOS (4.5-fold), and SOCS3 (2.3-fold). Thus, intense exercise transiently increases IL-6 and PDGF-BB proteins, and STAT3 phosphorylation is increased. These responses are preserved after intense exercise. This suggests they are not modified by training and may be an essential component of the adaptive responses to intense exercise.
authors.affiliation: Molecular Nutrition Unit, School of Exercise and Nutrition Science, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
authors.forename: Marissa K
authors.initials: MK
authors.lastname: Trenerry
authors.forename: Paul A
authors.initials: PA
authors.lastname: Della Gatta
authors.forename: Amy E
authors.initials: AE
authors.lastname: Larsen
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Garnham
authors.forename: David
authors.initials: D
authors.lastname: Cameron-Smith
mesh_terms: D000077214:Becaplermin; D015444:Exercise / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D053612:Janus Kinases / Q000097:blood* / Q000502:physiology; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D010766:Phosphorylation / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D020574:Proto-Oncogene Proteins c-sis; D055070:Resistance Training / Q000379:methods; D050796:STAT3 Transcription Factor / Q000096:biosynthesis* / Q000097:blood; D015398:Signal Transduction / Q000502:physiology; D013997:Time Factors; D055815:Young Adult
chemical_list: D015850:Interleukin-6; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000077214:Becaplermin; D053612:Janus Kinases