title: A common polymorphism of CYP4A11 is associated with blood pressure in a Chinese population.
abstract: Variants of the human CYP4A11, which belongs to the cytochrome P450, family 4, have been reported to be associated with hypertension in general populations. However, data in the Chinese population are limited. This study sought to assess the effect of CYP4A11 on the prevalence of hypertension and blood pressure in a Chinese population. Three tagging single nucleotide polymorphisms, rs9332982, rs4660980 and rs3890011, were genotyped in 1734 community-based participants. Individuals with secondary hypertension were excluded. Sex-pooled and sex-specific analysis for genotype-phenotype association were both conducted. We found rs9332982 T allele was nominally associated with higher prevalence of hypertension in women after adjustment for covariates (OR: 1.38, 95%CI: 1.06-1.81, P = 0.0183). The significance did not retain after Bonferroni correction. In blood pressure analysis restricted to normotensive individuals, rs4660980 was associated with both systolic (β = -3.17, P = 0.0011) and diastolic blood pressure (β = -1.75, P = 0.0010) in men. A common variant on CYP4A11 was associated with blood pressure in a Chinese population. Future studies are needed to confirm our findings.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center of Diabetes, Shanghai, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Jingyi
authors.initials: J
authors.lastname: Lu
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.forename: Congrong
authors.initials: C
authors.lastname: Wang
authors.forename: Weihui
authors.initials: W
authors.lastname: Yu
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.forename: Kunsan
authors.initials: K
authors.lastname: Xiang
authors.forename: Youfei
authors.initials: Y
authors.lastname: Guan
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D001794:Blood Pressure / Q000235:genetics*; D002681:China / Q000453:epidemiology; D042926:Cytochrome P-450 CYP4A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012737:Sex Factors
chemical_list: D003577:Cytochrome P-450 Enzyme System; C465478:CYP4A11 protein, human; D042926:Cytochrome P-450 CYP4A