title: Cholinesterase modulations in patients with acute bacterial meningitis.
abstract: BACKGROUND
  The circulating cholinesterases acetyl- and butyrylcholinesterase may be suppressed and subsequently released from the brain in acute bacterial meningitis.
  
  
  METHODS
  We report serum activities of acetylcholinesterase and butyrylcholinesterase in paired arterial and jugular venous samples from seven patients with acute bacterial meningitis and eight healthy controls. Paraoxonase 1, which protects these enzymes from oxidative inactivation, was also measured.
  
  
  CONCLUSIONS
  Acetyl- and butyrylcholinesterase activities were lower in patients, independently of changes in paraoxonase 1. Arterial and jugular venous enzyme activities were similar both in patients and controls, suggesting that no cerebral release was present.
authors.forename: Ronan M G
authors.initials: RM
authors.lastname: Berg
authors.forename: Keren
authors.initials: K
authors.lastname: Ofek
authors.forename: Tavs
authors.initials: T
authors.lastname: Qvist
authors.forename: Flemming
authors.initials: F
authors.lastname: Tofteng
authors.forename: Hermona
authors.initials: H
authors.lastname: Soreq
authors.forename: Kirsten
authors.initials: K
authors.lastname: Møller
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood*; D000208:Acute Disease; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002091:Butyrylcholinesterase / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D016920:Meningitis, Bacterial / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis
chemical_list: D015415:Biomarkers; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human