title: Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA.
abstract: The different protein isoforms generated from the vascular endothelial growth factor-A (VEGF-A) gene, an essential regulator of blood vessel formation, differ in biochemical property and functional activity. Despite the relevance of VEGF-A for both normal and pathologic angiogenesis, our understanding of the molecular mechanisms governing alternative splicing of its pre-mRNA is still in its infancy.
authors.affiliation: Molecular Medicine Laboratory; International Centre for Genetic Engineering and Biotechnology; Trieste, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Giacca