title: Function and histopathology of a cell adhesion molecule TSLC1 in cancer.
abstract: Even less than a decade since the discovery of TSLC1, overwhelming evidence demonstrates that the loss of TSLC1 expression by methylation-mediated epigenetic silencing or LOH is crucially implicated in various processes during tumorigenesis. Here, we summarize TSLC1 function, highlighting the concept that TSLC1 mediates the formation of tumor suppressor network via its multidomain structure and bridges extracellular adhesive activity with intracellular signaling. Next, we focus on the histopathology of TSLC1 in various cancers and the association with clinicopathological characteristics. On the basis of these, we propose that TSLC1 represents a promising biomarker for cancer diagnosis and a potential target for cancer therapy.
authors.affiliation: Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China. qilianl@yahoo.com
authors.forename: Qi-Lian
authors.initials: QL
authors.lastname: Liang
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Chen
authors.forename: Zhou-Yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Bi-Rong
authors.initials: BR
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D011379:Prognosis; D025521:Tumor Suppressor Proteins / Q000502:physiology*
chemical_list: D014408:Biomarkers, Tumor; C403514:CADM1 protein, human; D000075982:Cell Adhesion Molecule-1; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D025521:Tumor Suppressor Proteins