title: Experience with non-ablative fractional photothermolysis with a dual-mode laser device (1,440/1,320 nm): no considerable clinical effect on hypertrophic/acne scars and facial wrinkles.
abstract: In the literature, non-ablative fractionated photothermolysis (nFP) is accredited with improvement of wrinkles and scars combined with a reduced downtime. The purpose of this work was to evaluate the impact of a combination laser (1,320/1,440 nm) for nFP on hypertrophic scars, acne scars, and facial wrinkles. Thirty-six patients suffering from hypertrophic scars (n = 7), acne scars (n = 9), and wrinkles (n = 20) were treated using a combination Nd:YAG laser [λ(em) = 1,320 and 1,440 nm, pulse duration: 3-ms single pulse, fluence: 8.0-9.0 J/cm(2) (1,320 nm); 2.0-2.5 J/cm(2) (1,440 nm)]. The appearance of the treated condition was evaluated in a retrospective study by two blinded investigators based on follow-up photographs and by patient self-assessment. The frequency of side-effects was also assessed. Both patients and blinded observers rated the treatment results for hypertrophic scars and acne scars as slight improvement, and for wrinkles as equal as compared to baseline. No serious side-effects were reported. The light device used did not lead to a considerable clinical improvement of hypertrophic scars, acne scars, or wrinkles in this study.
authors.affiliation: Department of Dermatology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. philipp.babilas@klinik.uni-regensburg.de
authors.forename: Philipp
authors.initials: P
authors.lastname: Babilas
authors.forename: Stephan
authors.initials: S
authors.lastname: Schreml
authors.forename: Tatiana
authors.initials: T
authors.lastname: Eames
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hohenleutner
authors.forename: Michael
authors.initials: M
authors.lastname: Landthaler
authors.forename: Silvia
authors.initials: S
authors.lastname: Hohenleutner
mesh_terms: D000152:Acne Vulgaris / Q000532:radiotherapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D017439:Cicatrix, Hypertrophic / Q000532:radiotherapy*; D005145:Face / Q000473:pathology*; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008875:Middle Aged; D010146:Pain; D010147:Pain Measurement; D012189:Retrospective Studies; D015595:Skin Aging / Q000473:pathology*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult