title: A dosimetric system for quantitative cell irradiation experiments with laser-accelerated protons.
abstract: An integrated dosimetry and cell irradiation system (IDOCIS) with laser-accelerated proton beams was developed, characterized, calibrated and successfully used for systematic in vitro experiments. Due to the broad exponentially shaped energy spectrum, the low-energy range of the protons (<20 MeV) and the high pulse dose, the absolute dosimetry for this beam quality is challenging. Therefore, a dedicated Faraday cup is used as an energy and dose rate independent absolute dosimeter that has been calibrated consistently with three independent methods. A transmission ionization chamber providing online relative dose information is cross-calibrated against the Faraday cup. Providing both online and absolute dose information, the IDOCIS allows for quantitative dosimetric and radiobiological studies at current low-energy laser-accelerated proton beams. Finally, first dosimetric characterizations of a laser-accelerated proton beam with the IDOCIS are presented.
authors.affiliation: OncoRay-National Center for Radiation Research in Oncology, Technische Universität Dresden, Dresden, Germany. christian.richter@oncoray.de
authors.forename: C
authors.initials: C
authors.lastname: Richter
authors.forename: L
authors.initials: L
authors.lastname: Karsch
authors.forename: Y
authors.initials: Y
authors.lastname: Dammene
authors.forename: S D
authors.initials: SD
authors.lastname: Kraft
authors.forename: J
authors.initials: J
authors.lastname: Metzkes
authors.forename: U
authors.initials: U
authors.lastname: Schramm
authors.forename: M
authors.initials: M
authors.lastname: Schürer
authors.forename: M
authors.initials: M
authors.lastname: Sobiella
authors.forename: A
authors.initials: A
authors.lastname: Weber
authors.forename: K
authors.initials: K
authors.lastname: Zeil
authors.forename: J
authors.initials: J
authors.lastname: Pawelke
mesh_terms: D002138:Calibration; D002477:Cells / Q000528:radiation effects*; D006801:Humans; D007834:Lasers; D011522:Protons; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000295:instrumentation* / Q000379:methods
chemical_list: D011522:Protons