title: [Neuroimaging and neurobiology of social anxiety].
abstract: OBJECTIVE
  Social Anxiety Disorder (SAD) represents one of the most frequent psychiatric disorders. The results of a systematic review of the literature published until January 2010 on the neurobiology of SAD are reported, giving prominence to functional neuroimaging (fNI) findings.
  
  
  METHODS
  A literature search of neuroimaging and neurobiology studies of SAD was conducted on PubMed and Medline electronic archives and by canvassing English-language and other European languages publications. Eligible studies were restricted to those on adult population (age 16 to 65) and using DSM and ICD criteria.
  
  
  RESULTS
  The 19 reviewed fNI studies on SAD agree in identifying a dysfunction of five main cerebral areas: the amygdala, the medial prefrontal cortex, the insula, the hippocampus and the dorsolateral prefrontal cortex. Those findings strongly suggest the presence, in this disorder, of functional alterations in the neural systems involved in the genesis of fear, in the processing of emotional stimuli, in the "self" perception and in the evaluation of others' intentions.
  
  
  CONCLUSIONS
  Neurobiology research on SAD is still relatively young and, up to today, available findings are still not exhaustive. Nonetheless, a growing evidence from different lines of research seems to suggest that SAD patients may present a distinct biologic background compared to control subjects. Until now, however, no specific neurobiological aspect has been proposed for the SAD only. Per contra, results from fNI studies seem to indicate the presence of a common pattern of neural dysfunction in all the major anxiety disorders.
authors.affiliation: Dipartimento di Scienze Neurologiche e Psichiatriche, Università di Firenze. francesco.pietrini@unifi.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Pietrini
authors.forename: Lucia
authors.initials: L
authors.lastname: Godini
authors.forename: Lisa
authors.initials: L
authors.lastname: Lazzeretti
authors.forename: Laura
authors.initials: L
authors.lastname: Benni
authors.forename: Chiara
authors.initials: C
authors.lastname: Pracucci
authors.forename: Gabriela Alina
authors.initials: GA
authors.lastname: Talamba
authors.forename: Carlo
authors.initials: C
authors.lastname: Faravelli
mesh_terms: D001008:Anxiety Disorders / Q000175:diagnosis / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010698:Phobic Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012931:Social Environment