title: Global daily dynamics of the pineal transcriptome.
abstract: Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.
authors.affiliation: Instituto Tecnológico de Chascomús (Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús), Camino Circunvalación Laguna km 6 cc164, B7130IWA, Chascomús, Argentina.
authors.forename: Diego M
authors.initials: DM
authors.lastname: Bustos
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bailey
authors.forename: David
authors.initials: D
authors.lastname: Sugden
authors.forename: David A
authors.initials: DA
authors.lastname: Carter
authors.forename: Martin F
authors.initials: MF
authors.lastname: Rath
authors.forename: Morten
authors.initials: M
authors.lastname: Møller
authors.forename: Steven L
authors.initials: SL
authors.lastname: Coon
authors.forename: Joan L
authors.initials: JL
authors.lastname: Weller
authors.forename: David C
authors.initials: DC
authors.lastname: Klein
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D010870:Pineal Gland / Q000033:anatomy & histology / Q000378:metabolism*