title: Genetic biomarkers of health-related quality of life in pediatric asthma.
abstract: OBJECTIVE
  To determine the relationship between single nucleotide polymorphisms in candidate genes associated with multiple asthma phenotypes and health-related quality of life (HRQOL).
  
  
  METHODS
  A cross-sectional study was conducted at a pediatric hospital in 275 school-aged children diagnosed with asthma and their caregivers. Genomic DNA was obtained from children, and caregivers completed a measure of their child's HRQOL. Analysis of variance was used to investigate the association between single nucleotide polymorphisms and HRQOL.
  
  
  RESULTS
  Children homozygous for the major variant at IL-4RA rs 1805010 had significantly better HRQOL than their counterparts. Significant associations with pulmonary function were not observed.
  
  
  CONCLUSIONS
  Genes associated with asthma phenotype can be associated with HRQOL at least partly independent of pulmonary function.
authors.affiliation: Department of Pediatrics, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. sandra.cortina@cchmc.org
authors.forename: Sandra D
authors.initials: SD
authors.lastname: Cortina
authors.forename: Dennis
authors.initials: D
authors.lastname: Drotar
authors.forename: Mark
authors.initials: M
authors.lastname: Ericksen
authors.forename: Mark
authors.initials: M
authors.lastname: Lindsey
authors.forename: Tia L
authors.initials: TL
authors.lastname: Patterson
authors.forename: Jocelyn M Biagini
authors.initials: JM
authors.lastname: Myers
authors.forename: Melinda Butsch
authors.initials: MB
authors.lastname: Kovacic
authors.forename: Gurjit K Khurana
authors.initials: GK
authors.lastname: Hershey
mesh_terms: D000704:Analysis of Variance; D001249:Asthma / Q000235:genetics*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006720:Homozygote; D006776:Hospitals, Pediatric; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D018950:Lipopolysaccharide Receptors / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D019948:Receptors, Interleukin-4 / Q000235:genetics; D011795:Surveys and Questionnaires
chemical_list: D005819:Genetic Markers; D018793:Interleukin-13; D018950:Lipopolysaccharide Receptors; D019948:Receptors, Interleukin-4; D015847:Interleukin-4; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi