title: Short communication: severe immune suppression in patients infected with R5-tropic HIV-1 strains is associated with increased gp120 net charge at variable regions.
abstract: CXCR4-tropic viruses have been associated with advanced immune suppression. However, 50% of patients with AIDS exclusively harbor CCR5-tropic viruses. The net charge at HIV-1 envelope gp120 variable regions was examined in 66 HIV-1-infected individuals with CCR5-tropic viruses, of whom 30 had less than 200 cells/mm(3). A positive net charge at gp120 variable regions was significantly associated with lower CD4 counts. Thus, the net charge at gp120 variable regions could influence HIV-1 disease progression in subjects with CCR5-tropic viruses.
authors.affiliation: Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Seclén
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
authors.forename: María
authors.initials: M
authors.lastname: del Mar González
authors.forename: Juan
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: Eva
authors.initials: E
authors.lastname: Poveda
mesh_terms: D018791:CD4 Lymphocyte Count; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000737:chemistry* / Q000472:pathogenicity*; D006801:Humans; D007108:Immune Tolerance; D019713:Receptors, CCR5 / Q000378:metabolism; D015728:Receptors, HIV / Q000378:metabolism; D056189:Viral Tropism
chemical_list: D015699:HIV Envelope Protein gp120; D019713:Receptors, CCR5; D015728:Receptors, HIV; C514793:gp120 protein, Human immunodeficiency virus 1