title: First prebiotic generation of a ribonucleotide from adenine, D-ribose and trimetaphosphate.
abstract: Adenosine monophosphate isomers are obtained by self-assembling of adenine, D-ribose and trimetaphosphate in aqueous solution in good yields. This generation of a ribonucleotide from its three molecular components occurs in a one-pot reaction at room temperature for about 30-40 days and with high chemio-, regio-, and stereo-selectivity. Similar results are obtained with guanine. A mechanism is also proposed.
authors.affiliation: Department of Organic Chemistry A. Mangini ALMA MATER STUDIORUM-Università di Bologna Viale del Risorgimento, 4, Italy. baccolin@ms.fci.unibo.it
authors.forename: Graziano
authors.initials: G
authors.lastname: Baccolini
authors.forename: Carla
authors.initials: C
authors.lastname: Boga
authors.forename: Gabriele
authors.initials: G
authors.lastname: Micheletti
mesh_terms: D000225:Adenine / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry*; D056692:Prebiotics; D012265:Ribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D012266:Ribose / Q000737:chemistry*
chemical_list: D011122:Polyphosphates; D056692:Prebiotics; D012265:Ribonucleotides; D012266:Ribose; C009293:trimetaphosphoric acid; D000225:Adenine