title: Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate.
abstract: A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P=0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P=0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.
authors.affiliation: Department of Neurology, The Faculty Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavska 20, 625 00 Brno, Czech Republic. magdap@centrum.cz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Hladikova
authors.forename: Anna
authors.initials: A
authors.lastname: Vašků
authors.forename: Pavel
authors.initials: P
authors.lastname: Stourač
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Benešová
authors.forename: Josef
authors.initials: J
authors.lastname: Bednařík
mesh_terms: D000328:Adult; D000483:Alleles; D000808:Angiotensinogen / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000473:pathology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics
chemical_list: D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A