title: Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare centre.
abstract: OBJECTIVE
  To determine the microvascular and macrovascular complications and mortality incidence rates and to identify the related factors in patients recently diagnosed with type 2 diabetes between 1991 and 2000 and followed until 2006.
  
  
  METHODS
  Retrospective longitudinal study in a primary healthcare center. Patients without any measure of glycaemia in the 3 years previous to diabetes diagnosis were excluded. Annual incidence rates for microvascular and macrovascular complications and mortality were estimated. Analysis of KaplanMeier survival curves and Cox proportional risk models by gender were done.
  
  
  RESULTS
  Of 469 patients [mean age: 60.4 (SD 10.7) years, 53.9% women], 80 died principally of tumoral (38.7%) and cardiovascular (30%) causes. The mean follow-up period was 8.81 years. (SD 3.21). The complication rates per 1000 patients/year (95% CI) were: microvascular complications 29.11 (22.97-36.38), macrovascular complications 24.10 (19.05-30.08) and mortality 19.23 (15.25-23.93), all of those being significantly greater in males except for cerebrovascular disease. Complications and mortality were associated with age, HbA1c, HDL-cholesterol, blood pressure and smoking with a different significance for each gender. HbA1c was related to microvascular complications in both sexes and to macrovascular complications only in women.
  
  
  CONCLUSIONS
  The annual rates for death and complications in a Mediterranean type 2 diabetic patient cohort followed from diagnosis were lower than those published in Anglo-Saxon countries. Males showed higher death and complication rates except in terms of cerebrovascular disease. Predictors of complication and death were different depending on gender. In terms of mortality, unlike in other studies, only one-third of the deaths were for cardiovascular causes.
authors.affiliation: Primary Healthcare Center La Mina, SAP Litoral, Barcelona Family and Community Medicine Teaching Unit, Institut Català de la Salut, Sant Adrià de Besòs (Barcelona), Spain. mmata@medynet.com
authors.forename: M
authors.initials: M
authors.lastname: Mata-Cases
authors.forename: C
authors.initials: C
authors.lastname: De Prado-Lacueva
authors.forename: V
authors.initials: V
authors.lastname: Salido-Valencia
authors.forename: E
authors.initials: E
authors.lastname: Fernández-Bertolín
authors.forename: J
authors.initials: J
authors.lastname: Casermeiro-Cortés
authors.forename: M
authors.initials: M
authors.lastname: García-Durán
authors.forename: S
authors.initials: S
authors.lastname: Jabalera-López
authors.forename: M I
authors.initials: MI
authors.lastname: Fernández-Sanmartín
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000401:mortality*; D003925:Diabetic Angiopathies / Q000097:blood / Q000150:complications / Q000401:mortality*; D003928:Diabetic Nephropathies / Q000150:complications / Q000401:mortality*; D004812:Epidemiologic Methods; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin