title: [Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid].
abstract: The synthesis of a new group of maleopimaric acid amides containing fragments of the methyl esters of amino acids, aliphatic amines, imidazole and N-methylpiperazine was carried out. Ozonolysis of methyl maleopimarate flows through the cleavage of double bond C18(19) and the disclosure of anhydrous cycle with formation of secotriacid. As a result of screening of anti-inflammatory and antiulcer activity of maleopimaric acid derivatives new effective compounds such as methyl esters of maleopimaric acid and product of ozonolysis - diterpenic secotriacid, maleopimaric acid amide with L-leucine were revealed. An important advantage of the compounds studied is the low toxicity and the presence of bidirectional activity in the absence of adverse effects on the animal.
authors.forename: O B
authors.initials: OB
authors.lastname: Kazakova
authors.forename: E V
authors.initials: EV
authors.lastname: Tret'iakova
authors.forename: O S
authors.initials: OS
authors.lastname: Kukovinets
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
authors.forename: T I
authors.initials: TI
authors.lastname: Nazyrov
authors.forename: I V
authors.initials: IV
authors.lastname: Chudov
authors.forename: A F
authors.initials: AF
authors.lastname: Ismagilova
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010126:Ozone / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000577:Amides; D014315:Triterpenes; C027815:maleopimaric acid; D010126:Ozone