title: One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co.
abstract: We describe the synthesis of the dip (di-picolyl-carboxylate) bifunctional chelator system, capable of fast coordination of Cu(2+), (64)Cu(2+) and Co(2+), as well as the [M(CO)(3)](+)-core (M = (99m)Tc, Re); it displays a variety of binding modes--tridentate when protected, tetradentate when deprotected. Syntheses of both the benzyl-nitro derivative and the benzyl-amino derivatives are described. The latter was coupled to biotin to show the viability of the system for functionalization with biomolecules. Besides coordination chemistry with stable isotopes, we also present labelling data with (64)Cu and (99m)Tc, as well as in vitro stability studies.
authors.affiliation: Medicinal Inorganic Chemistry Group, Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
authors.forename: Eszter
authors.initials: E
authors.lastname: Boros
authors.forename: Yi-Heng Scott
authors.initials: YH
authors.lastname: Lin
authors.forename: Cara L
authors.initials: CL
authors.lastname: Ferreira
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Urs O
authors.initials: UO
authors.lastname: Häfeli
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Adam
authors.forename: Chris
authors.initials: C
authors.lastname: Orvig
mesh_terms: D002614:Chelating Agents / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry; D003301:Copper Radioisotopes / Q000737:chemistry; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D012211:Rhenium / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D056831:Coordination Complexes; D003301:Copper Radioisotopes; D003035:Cobalt; D012211:Rhenium; D013667:Technetium