title: In vivo feasibility case study for evaluating abdominal aortic aneurysm tissue properties and rupture potential using acoustic radiation force impulse imaging.
abstract: An abdominal aortic aneurysm (AAA) is defined as a permanent and irreversible localized dilatation of the abdominal aorta. A reliable, non-invasive method to assess the wall mechanics of an aneurysm may provide additional information regarding their susceptibility to rupture. Acoustic radiation force impulse (ARFI) imaging is a phenomenon associated with the propagation of acoustic waves in attenuating media. This study was a preliminary evaluation to explore the feasibility of using ARFI imaging to examine an AAA in vivo. A previously diagnosed in vivo aneurysm case study was imaged to demonstrate the viability of excitation of the abdominal aorta using ARFI imaging. Ex vivo experiments were used to assess an artificially induced aneurysm to establish its development and whether ARFI was able to capture the mechanical changes during artificial aneurysm formation. A combination of in vivo and ex vivo results demonstrated a proposed hypothesis of estimation of the tissue's stiffness properties. The study details a method for non-invasive rupture potential prediction of AAAs using patient-specific moduli to generate a physiological stiffness rupture potential index (PSRPI) of the AAA. Clinical feasibility of ARFI imaging as an additional surgical tool to interrogate AAAs was verified and methods to utilize this data as a diagnostic tool was demonstrated with the PSRPI.
authors.affiliation: University of Limerick, Materials and Surface Science Institute, Limerick, Ireland. aine.tierney@ul.ie
authors.forename: Aine P
authors.initials: AP
authors.lastname: Tierney
authors.forename: Anthony
authors.initials: A
authors.lastname: Callanan
authors.forename: Timothy M
authors.initials: TM
authors.lastname: McGloughlin
mesh_terms: D000162:Acoustics; D000368:Aged; D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D001019:Aortic Rupture / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D001696:Biomechanical Phenomena; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D010196:Pancreatic Elastase / Q000627:therapeutic use; D011336:Probability; D013552:Swine
chemical_list: D010196:Pancreatic Elastase