title: Risk factors for intrauterine fetal death (1988-2009).
abstract: OBJECTIVE
  To determine risk factors for intrauterine fetal death (IUFD).
  
  
  METHODS
  A retrospective population-based study, of all singleton deliveries between the years 1988-2009 was conducted. Intrapartum deaths, postpartum death, and multiple gestations were excluded. A multiple logistic regression model was used to determine independent risk factors.
  
  
  RESULTS
  During the study period, out of 228,239 singleton births, 1694 IUFD cases were recorded (7.4 per 1000 births). The following independent risk factors were identified in the logistic regression executed: Oligohydramnios (OR 2.6, 95% CI 2.1-3.2, p-value < 0.001), polyhydramnios (OR 1.8, 95% CI 1.4-2.2, p-value < 0.001), previous adverse perinatal outcome (OR 1.7, 95% CI 1.5-2.1, p-value < 0.001), congenital malformations (OR 2.0, 95% CI 1.8-2.3, p-value < 0.001), true knot of cord (OR 3.7, 95% CI 2.8-4.9, p-value < 0.001), meconium stained amniotic fluid (OR 2.7, 95% CI 2.3-3.0, p-value<0.001), placental abruption (OR 2.9, 95% CI 2.4-3.5, p-value < 0.001), advanced maternal age (OR 1.03, 95% CI 1.02-1.04, p-value < 0.001), and hypertensive disorders (OR 1.24, 95% CI 1.0-1.4, p-value = 0.026). Jewish ethnicity (versus Bedouin - OR 0.64, 95% CI 0.57-0.72, p-value < 0.001), gestational diabetes (OR 0.7, 95% CI 0.5-0.8, p-value = 0.001), previous cesarean section (OR 0.8, 95% CI 0.7-0.97, p-value = 0.019), and recurrent abortions (OR 0.8, 95% CI 0.6-0.9, p-value = 0.011) were negatively associated with IUFD.
  
  
  CONCLUSIONS
  Several independent risk factors were identified, suggesting a possible cause of death. Other pathologic conditions that facilitate tighter pregnancy surveillance and active management were found protective, pointing the benefit of such management approaches in high-risk pregnancies.
authors.affiliation: Faculty of Health Sciences, Joyce and Irving Goldman Medical School, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel. odedoh@gmail.com
authors.forename: Oded
authors.initials: O
authors.lastname: Ohana
authors.forename: Gershon
authors.initials: G
authors.lastname: Holcberg
authors.forename: Ruslan
authors.initials: R
authors.lastname: Sergienko
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D000328:Adult; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D046689:Fetal Mortality / Q000208:ethnology / Q000639:trends; D006801:Humans; D011153:Population; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D018566:Pregnancy, High-Risk / Q000502:physiology; D012189:Retrospective Studies; D012307:Risk Factors; D050497:Stillbirth / Q000453:epidemiology / Q000208:ethnology; D013997:Time Factors; D055815:Young Adult