title: Synthesis, crystal structure, antimicrobial activity and DNA-binding of hydrogen-bonded proton-transfer complex of 2,6-diaminopyridine with picric acid.
abstract: A proton-transfer (charge transfer) complex formed on the reaction between 2,6-diaminopyridine (donor) and picric acid (acceptor) was synthesized and characterized by FTIR, (1)H NMR, thermal and elemental analysis. The crystal structure determined by single-crystal X-ray diffraction indicates that cation and anion are joined together by strong N(+)-H- -O(-) type hydrogen bonds. The hydrogen-bonded charge transfer (HBCT) complex was screened for its pharmacology such as antimicrobial activity against various fungal and bacterial strains and Calf thymus DNA-binding. The results showed that HBCT complex (100μg/ml) exhibited good antibacterial antifungal activity as that of standard antibiotics Tetracycline and Nystatin. A molecular frame work through H-bonding interactions between neighboring moieties is found to be responsible for high melting point of resulting complex. This has been attributed to the formation of 1:1 HBCT complex.
authors.affiliation: Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh 202002, India. drishaatamu@gmail.com
authors.forename: Ishaat M
authors.initials: IM
authors.lastname: Khan
authors.forename: Afaq
authors.initials: A
authors.lastname: Ahmad
authors.forename: M F
authors.initials: MF
authors.lastname: Ullah
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D004579:Electron Transport; D005658:Fungi / Q000187:drug effects; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D010851:Picrates / Q000737:chemistry*; D011522:Protons; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D010851:Picrates; D011522:Protons; D011725:Pyridines; D004247:DNA; C005858:picric acid; C505797:2,6-diaminopyridine