title: The effect of flurbiprofen as prophylactic analgesic before hysterosalpingography.
abstract: Hysterosalpingography (HSG) is associated with pain during the four-step procedure. This prospective, double-blind, randomized, placebo-controlled study was conducted to investigate the effect of the analgesic flurbiprofen, administered prior to HSG, in 60 women. Thirty women were randomized to receive 100 mg of flurbiprofen, orally, 1 h prior to HSG and a further 30 women were randomized to receive placebo. Injection of contrast medium was more painful than the other steps in the HSG procedure in both groups; however, there was no significant between-group difference in terms of pain experienced in the individual steps of HSG. Pain scores at 5 and 30 min after the procedure were compared between the two groups. There was a significant decrease in the visual analogue scale pain score in the flurbiprofen-treated group compared with the placebo-treated group at both time points. Thus, the authors recommend flurbiprofen as a prophylactic analgesic to be administered before HSG procedures.
authors.affiliation: Department of Obstetrics and Gynaecology, School of Medicine, Dicle University, Diyarbakir, Turkey. alijnk@hotmail.com
authors.forename: A I
authors.initials: AI
authors.lastname: Guzel
authors.forename: U
authors.initials: U
authors.lastname: Kuyumcuoglu
authors.forename: M
authors.initials: M
authors.lastname: Erdemoğlu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D006801:Humans; D007047:Hysterosalpingography; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D010919:Placebos; D011446:Prospective Studies
chemical_list: D000700:Analgesics; D010919:Placebos; D005480:Flurbiprofen