title: Accuracy of multislice CT angiography for the assessment of in-stent restenoses in the iliac arteries at reduced dose: a phantom study.
abstract: OBJECTIVE
  We investigated the potential of low-dose CT angiography for accurate assessment of in-stent restenoses (ISRs) of the iliac artery.
  
  
  METHODS
  A Rando anthropomorphic phantom (Alderson Research Labs, Stanford, CA), custom-made wax simulating hyperplastic tissue and a nitinol stent were used to simulate a patient with clinically relevant iliac artery ISRs. The cylindrical lumen was filled with a solution of iodine contrast medium diluted in saline, representing a patient's blood during CT angiography. The phantom was subjected to standard- and low-dose angiographic exposures using a modern multidetector (MD) CT scanner. The percentage of ISR was determined using the profile along a line normal to the lumen axis on reconstructed images of 2 and 5 mm slice thickness. Percentage ISRs derived using the standard- and low-dose protocols were compared. In a preliminary study, seven patients with stents were subjected to standard- and low-dose MDCT angiography during follow-up. The resulting images were assessed and compared by two experienced radiologists.
  
  
  RESULTS
  The accuracy in measuring the percentage ISR was found to be better than 12% for all simulated stenoses. The differences between percentage ISRs measured on images obtained at 120 kVp/160 mAs and 80 kVp/80 mAs were below 6%. Patient image sets acquired using low-exposure factors were judged to be of satisfactory diagnostic quality. The assessment of ISR did not differ significantly between image sets acquired using the standard factors and those acquired using the low-exposure factors, although the mean reduction in patient effective dose was 48%.
  
  
  CONCLUSIONS
  A reduction in exposure factors during MDCT angiography of the iliac artery is possible without affecting the accuracy in the determination of ISRs.
authors.affiliation: Department of Medical Physics, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece. perisina@med.uoc.gr
authors.forename: K
authors.initials: K
authors.lastname: Perisinakis
authors.forename: E
authors.initials: E
authors.lastname: Manousaki
authors.forename: K
authors.initials: K
authors.lastname: Zourari
authors.forename: D
authors.initials: D
authors.lastname: Tsetis
authors.forename: A
authors.initials: A
authors.lastname: Tzedakis
authors.forename: A
authors.initials: A
authors.lastname: Papadakis
authors.forename: A
authors.initials: A
authors.lastname: Karantanas
authors.forename: J
authors.initials: J
authors.lastname: Damilakis
mesh_terms: D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging*; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging*; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging*; D008297:Male; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D012008:Recurrence; D015203:Reproducibility of Results; D015607:Stents; D014057:Tomography, X-Ray Computed / Q000379:methods*