title: [Clinical features and prognosis analysis of small-cell lung cancer complicated with hyponatremia].
abstract: OBJECTIVE
  To evaluate the clinical features and prognosis of small-cell lung cancer (SCLC) complicated with hyponatremia.
  
  
  METHODS
  The clinical data of 158 patients with SCLC of the Second Xiangya Hospital from January 2000 to December 2007 were studied retrospectively.
  
  
  RESULTS
  The incidence rate of hyponatremia in SCLC was 42.4%(67/158). The median survival time was 7.6 months in patients with subnormal serum sodium, and 14.1 months in patients with normal values. There was significantly different between 2 groups (P<0.001). The patients who did not fully regain normal values of serum sodium, had poorer survival (6.2 months) compared with the patients with normal serum sodium (10.3 months, P=0.044).
  
  
  CONCLUSIONS
  The incidence rate of hyponatremia in SCLC is high. The prognosis of SCLC with hyponatremia is very poor, especially in those who can not regain normal values of serum sodium after the treatment. So diagnosis and treatment at early stage are very important.
authors.affiliation: Department of Medical Oncology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ma
authors.forename: Xianling
authors.initials: X
authors.lastname: Liu
authors.forename: Chunhong
authors.initials: C
authors.lastname: Hu
authors.forename: Ming
authors.initials: M
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000453:epidemiology; D015994:Incidence; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055752:Small Cell Lung Carcinoma / Q000150:complications* / Q000175:diagnosis; D055815:Young Adult