title: Infectious mononucleosis with atypical manifestations accompanied by transient IgM antibody response for cytomegalovirus.
abstract: Infectious mononucleosis (IM) is a clinical syndrome caused by primary infection with Epstein-Barr virus (EBV) that is common in adolescents. In adults, particularly in elderly people, the clinical picture of IM tends to be atypical, often leading to a diagnostic challenge. Diagnosis is also complicated because infection with EBV can induce the synthesis of cross-reacting immunoglobulin M antibodies for other herpesviruses. We report an unusual case of infectious mononucleosis in a 34-year-old immunocompetent adult. Epidemiological studies indicate that the average age of primary EBV infection in developed countries is increasing. IM with atypical presentation will be a diagnostic challenge in the future as the number of EBV-naïve adults increases.
authors.affiliation: Department of Gastroenterology and Hematology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nishikawa
authors.forename: Hisashi
authors.initials: H
authors.lastname: Funada
authors.forename: Takako
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Haruka
authors.initials: H
authors.lastname: Fujinami
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Miyazono
authors.forename: Jun
authors.initials: J
authors.lastname: Murakami
authors.forename: Takahiko
authors.initials: T
authors.lastname: Kudo
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D008297:Male
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M