title: Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma.
abstract: Peptides serve as effective drugs and contrast agents in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this we have been developing new methods to create 'tailor-made' peptides and peptide mimetics with improved pharmacological and physical properties. In this work we introduce novel peptide and small molecule conjugated molecules for earlier diagnosis and treatment of melanoma.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Minying
authors.initials: M
authors.lastname: Cai
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Liu
authors.forename: Hongchang
authors.initials: H
authors.lastname: Qu
authors.forename: Helen
authors.initials: H
authors.lastname: Fan
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Zheng
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Hruby
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D045744:Cell Line, Tumor; D055088:Early Detection of Cancer; D057809:HEK293 Cells; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D008545:Melanoma / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D044102:Receptor, Melanocortin, Type 1 / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D044102:Receptor, Melanocortin, Type 1; D009074:Melanocyte-Stimulating Hormones