title: Cytomorphology of giant cell glioblastoma: Report of a case and brief review of literature.
abstract: Giant cell glioblastoma is a histological variant of glioblastoma that accounts for less than 1% of intracranial tumors and to 5% of glioblastoma. They occur at any age and are likely to affect the younger as well the older age group unlike the conventional glioblastoma multiforme (GBM). They are often located subcortically in the temporal and parietal lobes. Cytological descriptions of giant cell glioblastoma are extremely rare. We describe squash cytomorphology of giant cell glioblastoma of left posterior frontal region in 35-year-old male. The squash smears were moderately cellular displaying malignant astrocytic tumor cells disposed in cohesive clusters and dispersed population on a necrotic background. Most striking feature was numerous multinucleated giant cells. We also discuss the differential diagnosis in light of relevant literature.
authors.affiliation: Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, India. sushilapath@yahoo.com
authors.forename: Sushila
authors.initials: S
authors.lastname: Jaiswal
authors.forename: Mukul
authors.initials: M
authors.lastname: Vij
authors.forename: Awadhesh Kumar
authors.initials: AK
authors.lastname: Jaiswal
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Rakesh
authors.initials: R
authors.lastname: Pandey
mesh_terms: D000328:Adult; D002467:Cell Nucleus / Q000737:chemistry / Q000473:pathology; D002843:Chromatin / Q000737:chemistry / Q000473:pathology; D003581:Cytodiagnosis; D005625:Frontal Lobe / Q000473:pathology*; D015726:Giant Cells / Q000737:chemistry / Q000473:pathology*; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008938:Mitosis
chemical_list: D002843:Chromatin