title: Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapy.
abstract: Although cancer treatment with radiation can produce high cure rates, adverse effects often result from radiotherapy. These toxicities are manifested as damage to normal tissues and organs in the radiation field. In recognition of the substantial variation in the intrinsic response of individuals to radiation, an effort began approximately 10 years ago to discover the genetic markers, primarily SNPs, which are associated with susceptibility for the development of these adverse responses to radiation therapy. The goal of this research is to identify the SNPs that could serve as the basis of an assay to predict which cancer patients are most likely to develop complications resulting from radiotherapy. This would permit personalization and optimization of the treatment plan for each cancer patient.
authors.affiliation: Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA. barry.rosenstein@mssm.edu
authors.forename: Barry S
authors.initials: BS
authors.lastname: Rosenstein
mesh_terms: D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D020641:Polymorphism, Single Nucleotide; D011832:Radiation Injuries / Q000235:genetics*; D011836:Radiation Tolerance / Q000235:genetics*; D011878:Radiotherapy / Q000009:adverse effects