title: The value of serum biomarkers (Bc1, Bc2, Bc3) in the diagnosis of early breast cancer.
abstract: BACKGROUND
  Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF) is an approach to biomarker discovery that combines chromatography and mass spectrometry. We aimed to consider the efficacy of Bc1, Bc2, and Bc3 serum biomarkers on early detection of breast cancer (BC) in this study.
  
  
  METHODS
  In this prospective study, 91 patients who were admitted to our hospital between January 2007 and July 2008 were included. Serum samples from 91 women were stored at -80 °C until use. The cancer group included 27 cases of BC. The benign breast disease group included 24 women with benign breast diseases and control group 37 age-matched apparently healthy women. The data obtained for these three groups of patients was worked out for each serum biomarker (Bc1, Bc2, and Bc3) by using SELDI-TOF individually and compared with each other separately and evaluated statistically.
  
  
  RESULTS
  Bc2 possesses the highest individual diagnostic power. Bc2 was statistically significant in comparison between the malignant disease group, control group and benign disease group. Bc1 was statistically significant in the malignant disease group compared to control group as well as in the benign disease group compared to control group. Thus Bc1, rather than showing malignant progression, it shows tumoral progression or inflammatory process. Bc3 was found upregulated in all malignant cases; however, it was not statistically significant compared to the benign disease group or the control group.
  
  
  CONCLUSIONS
  It has been shown that Bc2 profiles might be useful in clinical practice to improve BC diagnosis. However none of the proteomics reach reasonable AUC values for the discrimination of the BC. Additional confirmation in larger and similarly-designed prospective studies is needed to consider of the efficacy of Bc1 and Bc2 in early diagnosis of the BC.
authors.affiliation: İzmir Atatürk Training and Research Hospital 1st Surgical Clinic, Turkey. kemalatahan@yahoo.com.tr
authors.forename: Kemal
authors.initials: K
authors.lastname: Atahan
authors.forename: Hakan
authors.initials: H
authors.lastname: Küpeli
authors.forename: Serhat
authors.initials: S
authors.lastname: Gür
authors.forename: Türkan
authors.initials: T
authors.lastname: Yiğitbaşı
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Baskın
authors.forename: Seyran
authors.initials: S
authors.lastname: Yiğit
authors.forename: Mehmet
authors.initials: M
authors.lastname: Deniz
authors.forename: Atilla
authors.initials: A
authors.lastname: Cökmez
authors.forename: Ercüment
authors.initials: E
authors.lastname: Tarcan
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis*; D016022:Case-Control Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D011446:Prospective Studies; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D014408:Biomarkers, Tumor