title: Modulatory action of α-tocopherol on erythrocyte membrane adenosine triphosphatase against radiation damage in oral cancer.
abstract: To investigate the possible effects of α-tocopherol on erythrocyte membrane adenosine triphosphatases against radiation damage in oral cancer patients. Adenosine triphosphatase activities were analysed in oral cancer patients before and after radiotherapy (at a dosage of 6000 cGY in five fractions per week for a period of six weeks) and after supplemented with α-tocopherol (400 IU per day for entire period of radiotherapy). The membrane bound enzymes such as Na(+)/K(+)-ATPase, Ca(2+)-ATPase, Mg(2+)-ATPase and some trace elements were altered in oral cancer patients before and after radiotherapy. Supplemented with α-tocopherol modulates the erythrocyte membrane which is damaged by radiotherapy which suggests that α-tocopherol protects the erythrocyte membrane from radiation damage in oral cancer patients.
authors.affiliation: Department of Biotechnology, Sri Ramachandra University, Chennai, India. chiresh2006@yahoo.com
authors.forename: Subramaniam
authors.initials: S
authors.lastname: Chitra
authors.forename: Chennam Srinivasulu
authors.initials: CS
authors.lastname: Shyamaladevi
mesh_terms: D000251:Adenosine Triphosphatases / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D000328:Adult; D000368:Aged; D017301:Ca(2+) Mg(2+)-ATPase / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D019587:Dietary Supplements; D004910:Erythrocyte Membrane / Q000201:enzymology* / Q000378:metabolism / Q000528:radiation effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000517:prevention & control*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D024502:alpha-Tocopherol