title: Mechanisms involved in the expansion of Tregs during pregnancy: role of IL-2/STAT5 signalling.
abstract: Several studies have reported that the fine-tuning of regulatory T cells (Tregs) is required for a successful pregnancy and for the control of autoimmune diseases. Here, we review the mechanisms that control the expansion of Tregs, based on insights obtained from the study of women suffering unsuccessful pregnancies and on recent data from patients with autoimmune diseases or with chronic viral infections such as HCV. In particular, we review the role of endocrine factors and IL-2/STAT5 signalling in the impaired expansion of Tregs.
authors.affiliation: Immunogenetics Laboratory, Clinical Hospital, José de San Martín, Buenos Aires, Argentina. lfainboim@hospitaldeclinicas.uba.ar
authors.forename: L
authors.initials: L
authors.lastname: Fainboim
authors.forename: L
authors.initials: L
authors.lastname: Arruvito
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D005260:Female; D012739:Gonadal Steroid Hormones / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D050799:STAT5 Transcription Factor / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D012739:Gonadal Steroid Hormones; D007376:Interleukin-2; D050799:STAT5 Transcription Factor