title: Continuous endurance-type exercise training does not modulate satellite cell content in obese type 2 diabetes patients.
abstract: Endurance-type exercise training represents a cornerstone in type 2 diabetes treatment. However, the effects of prolonged continuous, endurance-type exercise on muscle fiber characteristics remain equivocal. Fifteen obese male type 2 diabetes patients (61 ± 6 years) participated in a 6-month continuous, endurance-type exercise program. Muscle biopsies were collected before, and after 2 and 6 months of intervention. Muscle fiber type-specific composition, size, and satellite cell (SC) and myonuclear content were determined by immunohistochemistry. Although continuous endurance-type exercise training lowered total body weight and reduced fat mass, no changes were observed in leg lean mass. At baseline, SC content was significantly lower in type II compared with type I muscle fibers. No change in SC content was observed after exercise training. Continuous endurance-type exercise training lowers fat mass, but it does not increase leg lean mass and/or modulate muscle fiber characteristics in type 2 diabetes patients.
authors.affiliation: Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, P.O. Box 616, Maastricht 6200 MD, The Netherlands.
authors.forename: Tim
authors.initials: T
authors.lastname: Snijders
authors.forename: Lex B
authors.initials: LB
authors.lastname: Verdijk
authors.forename: Dominique
authors.initials: D
authors.lastname: Hansen
authors.forename: Paul
authors.initials: P
authors.lastname: Dendale
authors.forename: Luc J C
authors.initials: LJ
authors.lastname: van Loon
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000473:pathology / Q000502:physiology; D009765:Obesity / Q000097:blood* / Q000473:pathology / Q000628:therapy; D010807:Physical Endurance / Q000502:physiology*; D027161:Satellite Cells, Perineuronal / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D013997:Time Factors