title: A randomized trial of microdose leuprolide acetate protocol versus luteal phase ganirelix protocol in predicted poor responders.
abstract: We performed a randomized trial to compare IVF outcomes in 54 poor responder patients undergoing a microdose leuprolide acetate (LA) protocol or a GnRH antagonist protocol incorporating a luteal phase E(2) patch and GnRH antagonist in the preceding menstrual cycle. Cancellation rates, number of oocytes retrieved, clinical pregnancy rates (PR), and ongoing PRs were similar between the two groups.
authors.affiliation: Center for Advanced Reproductive Services, University of Connecticut Heath Center, Farmington, Connecticut 06030-6224, USA. diluigi@uchc.edu
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: DiLuigi
authors.forename: Lawrence
authors.initials: L
authors.lastname: Engmann
authors.forename: David W
authors.initials: DW
authors.lastname: Schmidt
authors.forename: Claudio A
authors.initials: CA
authors.lastname: Benadiva
authors.forename: John C
authors.initials: JC
authors.lastname: Nulsen
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003237:Connecticut; D004334:Drug Administration Schedule; D004624:Embryo Transfer; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage*; D008183:Luteal Phase; D054315:Oocyte Retrieval; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D013997:Time Factors; D057968:Transdermal Patch; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D016729:Leuprolide; C061018:ganirelix