title: Insulin-like growth factor-1 levels in twins and its correlation with discordance.
abstract: This study aims to determine whether fetal growth is related to insulin-like growth factor-1 in dichorionic and monochorionic twins and also aims to investigate the correlation of insulin-like growth factor-1 to birthweight discordance in twins. We studied 100 women with twin pregnancies. The correlation tests of 36 discordant twins (15 monochorionic, 21 dichorionic) showed correlation between insulin-like growth factor-1 difference and birthweight discordance (insulin-like growth factor-1 vs. birthweight of first twin, r = +0.915, at 0.01 level, IGF-1 vs birthweight of second twin r = +0.790, at 0.01 level). In 49 monochorionic twins, independent of discordance, there was a correlation between birthweight discordance and insulin-like growth factor-1 difference (r = .538, at the 0.01 level). This correlation was not significant in dichorionic twins, r = .144, p = .01. These data suggest that growth discordances of twins exposed to the same maternal environment may be due to variations in IGF-1, depending upon the genetic similarity.
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey.
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.forename: Ferhat
authors.initials: F
authors.lastname: Cekmez
authors.forename: Serdar Ümit
authors.initials: SÜ
authors.lastname: Sarici
authors.forename: Ayşe
authors.initials: A
authors.lastname: Korkmaz
authors.forename: Murat
authors.initials: M
authors.lastname: Yurdakok
mesh_terms: D001724:Birth Weight; D005260:Female; D047109:Fetal Development; D005865:Gestational Age; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000235:genetics; D011247:Pregnancy; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*
chemical_list: D007334:Insulin-Like Growth Factor I