title: Hypophosphatemia in kidney transplant recipients: report of acute phosphate nephropathy as a complication of therapy.
abstract: Hypophosphatemia is a common complication after kidney transplant, affecting >90% of patients. However, no specific recommendations for phosphate repletion exist for transplant recipients. We report a case of a 70-year-old highly sensitized woman with end-stage renal disease caused by diabetic nephropathy who underwent deceased donor kidney transplant. Four weeks later, she was noted to have hypophosphatemia with undetectable serum phosphate levels, and she reported mild diarrhea. She was started on oral phosphate supplementation. On a routine visit 2 weeks later, she was found to have an acute increase in serum creatinine level and kidney biopsy was performed. We discuss the causes, management, and complications of hypophosphatemia in kidney transplant.
authors.affiliation: Transplantation Research Center, Renal Division, Brigham & Women's Hospital, Children's Hospital Boston, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Leonardo V
authors.initials: LV
authors.lastname: Riella
authors.forename: Helmut G
authors.initials: HG
authors.lastname: Rennke
authors.forename: Monica
authors.initials: M
authors.lastname: Grafals
authors.forename: Anil
authors.initials: A
authors.lastname: Chandraker
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000284:Administration, Oral; D000368:Aged; D001706:Biopsy; D017610:Calcium Compounds / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D017674:Hypophosphatemia / Q000188:drug therapy* / Q000209:etiology*; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D010710:Phosphates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000085:Acetates; D017610:Calcium Compounds; D010710:Phosphates; D003404:Creatinine; C120662:calcium acetate