title: Computational design of peptide ligands.
abstract: Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this potential drug class. However, structural insights into the architecture of protein-peptide interfaces have recently culminated in several computational approaches for the rational design of peptides that target proteins. These methods provide a valuable alternative to experimental high-resolution structures of target protein-peptide complexes, bringing closer the dream of in silico designed peptides for therapeutic applications.
authors.affiliation: VIB SWITCH Laboratory, Flanders Institute of Biotechnology (VIB), Pleinlaan 2, 1050 Brussels, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Vanhee
authors.forename: Almer M
authors.initials: AM
authors.lastname: van der Sloot
authors.forename: Erik
authors.initials: E
authors.lastname: Verschueren
authors.forename: Luis
authors.initials: L
authors.lastname: Serrano
authors.forename: Frederic
authors.initials: F
authors.lastname: Rousseau
authors.forename: Joost
authors.initials: J
authors.lastname: Schymkowitz
mesh_terms: D019295:Computational Biology / Q000379:methods*; D015195:Drug Design; D008024:Ligands; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding
chemical_list: D008024:Ligands; D010455:Peptides