title: Childhood outcomes of neonates diagnosed with portal vein thrombosis.
abstract: OBJECTIVE
  The study aims to determine childhood outcomes of neonates diagnosed with portal vein thrombosis (PVT).
  
  
  METHODS
  A retrospective chart review of neonates diagnosed with PVT who had documented follow up (physical examination, laboratory tests or ultrasonographic examination) at the age of 2 years or beyond was conducted.
  
  
  RESULTS
  Data were available for 70 children (71% of eligible neonates) at a median age of 5 years (range 2-8 years). Physical examination was unremarkable in all who were examined (n= 68). Twenty-five children had liver functions assessed and only mild abnormalities were detected in nine children. Six of 25 patients tested for thrombophilia showed abnormalities. Thirty-seven children had ultrasonographic follow up. Left lobar atrophy (LLA) was noted in 20 children (16 had isolated LLA, two had LLA and splenomegaly, and two had LLA and portal hypertension). Five children who had normal ultrasound examinations at discharge had splenomegaly (two with additional finding of LLA) at follow up. Two children with portal hypertension diagnosed during neonatal period needed porta-caval shunting.
  
  
  CONCLUSIONS
  Our results show that among patients, who had PVT as neonates, 28% still had asymptomatic LLA in childhood, 7% had slowly progressive splenomegaly and 3% required shunting because of progression of portal hypertension. Ultrasonographic follow up was the most sensitive method in detecting progression associated with neonatal PVT. Until more data are available, periodic long-term ultrasonographic follow up should be considered for neonates diagnosed with PVT.
authors.affiliation: Neonatology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel. irismorag@gmail.com
authors.forename: Iris
authors.initials: I
authors.lastname: Morag
authors.forename: Prakesh S
authors.initials: PS
authors.lastname: Shah
authors.forename: Monica
authors.initials: M
authors.lastname: Epelman
authors.forename: Alan
authors.initials: A
authors.lastname: Daneman
authors.forename: Tzipi
authors.initials: T
authors.lastname: Strauss
authors.forename: Aideen M
authors.initials: AM
authors.lastname: Moore
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D007231:Infant, Newborn; D008297:Male; D008485:Medical Audit; D009864:Ontario; D017063:Outcome Assessment, Health Care; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000601:surgery