title: Early carcinoma of the esophagus associated with achalasia treated by endoscopic mucosal resection: report of a case.
abstract: A case of endoscopically resected early esophageal carcinoma associated with achalasia is reported. A 63-year-old woman was made diagnosis of esophageal achalasia, sigmoid type and grade III. The patient was operated by Tokai University method, Heller's long esophagomyectomy, Hill's posterior cardiopexy, fundoplication and selective proximal vagotomy using a laparotomy. Two years and six months after the operation, an early carcinoma of type 0-IIb, 1cm in size, was detected in the upper thoracic esophagus, and treated by endoscopic mucosal resection using EEMR-tube method. Pathological examination revealed proliferation of squamous cell carcinoma in situ (Tis: m1). The entire esophageal mucosa around the carcinoma demonstrated hyperplastic changes of stratified squamous epithelium and foci of dysplastic changes. In the patient of achalasia, food stasis in esophagus is thought to induce chronic hyperplastic esophagitis, converting eventually to malignant transformation. Achalasia is known as a risk factor of esophageal carcinoma. Early operation or good drainage of the esophageal lumen might reduce the risk. Long-term follow-up for patients of achalasia by endoscopic screening is recommended.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193 Japan. o-chino@is.icc.u-tokai.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Chino
authors.forename: Hideo
authors.initials: H
authors.lastname: Shimada
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kise
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nishi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hara
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Makiko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajiwara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D004931:Esophageal Achalasia / Q000150:complications / Q000473:pathology / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome