title: Emerging diagnostic and therapeutic molecular imaging applications in vascular disease.
abstract: Assessment of vascular disease has evolved from mere indirect and direct measurements of luminal stenosis to sophisticated imaging methods to depict millimeter structural changes of the vasculature. In the near future, the emergence of multimodal molecular imaging strategies may enable robust therapeutic and diagnostic ('theragnostic') approaches to vascular diseases that comprehensively consider structural, functional, biological and genomic characteristics of the disease in individualized risk assessment, early diagnosis and delivery of targeted interventions.This review presents a summary of recent preclinical and clinical developments in molecular imaging and theragnostic applications covering diverse atherosclerosis events such as endothelial activation, macrophage inflammatory activity, plaque neovascularization and arterial thrombosis. The main focus is on molecular targets designed for imaging platforms commonly used in clinical medicine including magnetic resonance, computed tomography and positron emission tomography. A special emphasis is given to vascular ultrasound applications, considering the important role this imaging platform plays in the clinical and research practice of the vascular medicine specialty.
authors.affiliation: Cardiovascular Division, Vascular Medicine Section, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Luis.Eraso@uphs.upenn.edu
authors.forename: Luis H
authors.initials: LH
authors.lastname: Eraso
authors.forename: Muredach P
authors.initials: MP
authors.lastname: Reilly
authors.forename: Chandra
authors.initials: C
authors.lastname: Sehgal
authors.forename: Emile R
authors.initials: ER
authors.lastname: Mohler
mesh_terms: D050197:Atherosclerosis / Q000175:diagnosis / Q000000981:diagnostic imaging; D016503:Drug Delivery Systems / Q000639:trends; D052203:Ferrosoferric Oxide; D006801:Humans; D057054:Molecular Imaging / Q000379:methods / Q000639:trends*; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D058226:Plaque, Atherosclerotic / Q000175:diagnosis / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D015912:Thrombolytic Therapy / Q000379:methods; D013927:Thrombosis / Q000175:diagnosis; D014463:Ultrasonography; D014652:Vascular Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*
chemical_list: D019275:Radiopharmaceuticals; D052203:Ferrosoferric Oxide