title: Static magnetic field affects oxidative stress in mouse cochlea.
abstract: OBJECTIVE
  It has been shown that oxidative stress plays an important role in development of noise induced hearing loss. Since static magnetic fields (SMF) exposure may alter dynamics of oxidative processes in the tissue, the aim of the study was to assess the influence of SMF on noise-induced alteration in the cochlear level of reactive oxygen species (ROS) and hearing thresholds.
  
  
  METHODS
  Auditory brainstem response (ABR), lipid peroxidation (LPO) levels, super-oxide dismutase (SOD) activity and catalase activity were assessed in the cochlea prior to, and at five time-points over two weeks following exposure of C57BL/6 mice to 8h, 119 dB SPL, 4 kHz octave band noise.
  
  
  RESULTS
  The ABR indicated no permanent functional damage due to noise exposure either for the 4 kHz and 8 kHz SMF-exposed group or for animals not exposed to SMF. However, significant differences in LPO level, catalase and SOD activity between animals exposed to noise and SMF and those exposed to noise only were observed.
  
  
  CONCLUSIONS
  The results suggest that SMF causes an increase in ROS level in the cochlea after noise exposure and, at the same time, it speeds up activation of antioxidative enzymes.
authors.affiliation: Electromagnetic Hazards Laboratory, Nofer Institute of Occupational Medicine, Łódź, Poland. piopolit@imp.lodz.pl
authors.forename: Piotr
authors.initials: P
authors.lastname: Politański
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Rajkowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pawlaczyk-Łuszczyńska
authors.forename: Adam
authors.initials: A
authors.lastname: Dudarewicz
authors.forename: Aneta
authors.initials: A
authors.lastname: Wiktorek-Smagur
authors.forename: Mariola
authors.initials: M
authors.lastname: Sliwińska-Kowalska
authors.forename: Marek
authors.initials: M
authors.lastname: Zmyślony
mesh_terms: D000818:Animals; D003051:Cochlea / Q000528:radiation effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006309:Hearing / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009622:Noise / Q000009:adverse effects; D018384:Oxidative Stress / Q000528:radiation effects*; D011044:Poland; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species