title: Expression Of Ki-67 and MUC1 In mucoepidermoid carcinomas of young and adult patients: prognostic implications.
abstract: Mucoepidermoid cancer (MEC) is the most malignant neoplasm of minor salivary glands. The aim of this study was to compare the expression of Ki-67 and MUC1 and clinicopathological data of mucoepidermoid carcinoma (MEC) in minor salivary glands of young and adult patients. The MEC cases in patients under 25 years old (n=8) and over 26 year old (n=8) were matched by gender, location and TNM staging. Immunohistochemical analysis of Ki-67 and MUC1 was carried out and correlated with clinicopathological data. The expression of Ki-67 and MUC1 was similar between the groups, although a tendency towards higher Ki-67 and MUC1 expression was observed in the younger group. Despite no significant differences, survival time was shorter in adults (71.37±17.44 months) compared to the younger group (97.62±25.81). While no patient deaths or tumor recurrences were found in the younger patient group, the adult group presented recurrence in 25% of cases and one patient died. In conclusion, our findings showed that age can be an important factor in MEC prognosis.
authors.affiliation: Department of Oral Medicine (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil. cintiafg@uol.com.br
authors.forename: Cíntia Ferreira
authors.initials: CF
authors.lastname: Gonçalves
authors.forename: Marília Oliveira
authors.initials: MO
authors.lastname: Morais
authors.forename: Rita de Cássia Gonçalves
authors.initials: Rde C
authors.lastname: Alencar
authors.forename: Eliane Duarte
authors.initials: ED
authors.lastname: Mota
authors.forename: Tarcília Aparecida
authors.initials: TA
authors.lastname: Silva
authors.forename: Aline Carvalho
authors.initials: AC
authors.lastname: Batista
authors.forename: Elismauro Francisco
authors.initials: EF
authors.lastname: Mendonça
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism* / Q000556:secondary; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D018396:Mucin-1 / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012470:Salivary Glands, Minor / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; C060192:MUC1 protein, human; D018396:Mucin-1