title: The simultaneous electrochemical detection of ascorbic acid, dopamine, and uric acid using graphene/size-selected Pt nanocomposites.
abstract: In this study, a graphene/Pt-modified glassy carbon (GC) electrode was created to simultaneously characterize ascorbic acid (AA), dopamine (DA), and uric acid (UA) levels via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). During the preparation of the nanocomposite, size-selected Pt nanoparticles with a mean diameter of 1.7 nm were self-assembled onto the graphene surface. In the simultaneous detection of the three aforementioned analytes using CV, the electrochemical potential differences among the three detected peaks were 185 mV (AA to DA), 144 mV (DA to UA), and 329 mV (AA and UA), respectively. In comparison to the CV results of bare GC and graphene-modified GC electrodes, the large electrochemical potential difference that is achieved via the use of the graphene/Pt nanocomposites is essential to the distinguishing of these three analytes. An optimized adsorption of size-selected Pt colloidal nanoparticles onto the graphene surface results in a graphene/Pt nanocomposite that can provide a good platform for the routine analysis of AA, DA, and UA.
authors.affiliation: Department of Chemical and Materials Engineering, Chang Gung University, Kwei-Shan, Tao-Yuan 333, Taiwan. sunchialiang@gmail.com
authors.forename: Chia-Liang
authors.initials: CL
authors.lastname: Sun
authors.forename: Hsin-Hsien
authors.initials: HH
authors.lastname: Lee
authors.forename: Jen-Ming
authors.initials: JM
authors.lastname: Yang
authors.forename: Ching-Chou
authors.initials: CC
authors.lastname: Wu
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D015374:Biosensing Techniques / Q000379:methods*; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D005465:Fluorocarbon Polymers / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D014527:Uric Acid / Q000032:analysis*
chemical_list: D005465:Fluorocarbon Polymers; D014527:Uric Acid; C040402:perfluorosulfonic acid; D010984:Platinum; D006108:Graphite; D001205:Ascorbic Acid; D004298:Dopamine