title: Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.
abstract: Developmental neurotoxicity testing (DNT) is perceived by many stakeholders to be an area in critical need of alternative methods to current animal testing protocols and guidelines. An immediate goal is to develop test methods that are capable of screening large numbers of chemicals. This document provides recommendations for developing alternative DNT approaches that will generate the type of data required for evaluating and comparing predictive capacity and efficiency across test methods and laboratories. These recommendations were originally drafted to stimulate and focus discussions of alternative testing methods and models for DNT at the TestSmart DNT II meeting (http://caat.jhsph.edu/programs/workshops/dnt2.html) and this document reflects critical feedback from all stakeholders that participated in this meeting. The intent of this document is to serve as a catalyst for engaging the research community in the development of DNT alternatives and it is expected that these recommendations will continue to evolve with the science.
authors.affiliation: National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research triangle Park, NC 27711, USA. crofton.kevin@epamail.epa.gov
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Crofton
authors.forename: William R
authors.initials: WR
authors.lastname: Mundy
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Lein
authors.forename: Anna
authors.initials: A
authors.lastname: Bal-Price
authors.forename: Sandra
authors.initials: S
authors.lastname: Coecke
authors.forename: Andrea E M
authors.initials: AE
authors.lastname: Seiler
authors.forename: Holger
authors.initials: H
authors.lastname: Knaut
authors.forename: Leonora
authors.initials: L
authors.lastname: Buzanska
authors.forename: Alan
authors.initials: A
authors.lastname: Goldberg
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods*; D000818:Animals; D002460:Cell Line; D015386:Hazardous Substances / Q000633:toxicity*; D020258:Neurotoxicity Syndromes; D012680:Sensitivity and Specificity; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D015386:Hazardous Substances