title: A case of a testosterone-secreting oncocytic adrenocortical carcinoma.
abstract: Oncocytic neoplasms are most rarely found in the adrenal gland. They are usually benign and non-functioning. We present a case of a testosterone-secreting oncocytic adrenocortical carcinoma in a 19-year-old female who presented with acne, hirsutism and irregular menses. Clinical investigations revealed an elevated testosterone and DHEA-S and a 4×5 cm left adrenal mass. The tumour was successfully excised. The histology showed the tumour to be comprised of oncocytic cells with granular, eosinophilic cytoplasm, features consistent with an oncocytic carcinoma. This is the first case presented of a testosterone-secreting oncocytic adrenocortical carcinoma.
authors.affiliation: Department of Surgery, Christchurch Hospital, Christchurch, New Zealand. mmunx@hotmail.com
authors.forename: Munanga
authors.initials: M
authors.lastname: Mwandila
authors.forename: Hayley
authors.initials: H
authors.lastname: Waller
authors.forename: Victoria
authors.initials: V
authors.lastname: Stott
authors.forename: Philippa
authors.initials: P
authors.lastname: Mercer
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D000315:Adrenalectomy / Q000379:methods; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000378:metabolism*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D013739:Testosterone / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D013739:Testosterone