title: Anaphylactic reaction after methylene blue-treated plasma transfusion.
abstract: Methylene blue-treated fresh-frozen plasma (MB-FFP) is mainly used in Europe. The advantage of the methylene blue system is that units can be treated individually. The combined action of methylene blue and illumination is a photodynamic process preventing viral RNA and DNA replication. We report the first immediate allergic hypersensitivity reaction to methylene blue-treated plasma transfusion. The clinical course and subsequent assessment of the allergic reaction, including skin tests and basophil activation test, confirmed methylene blue-induced IgE-mediated anaphylaxis. All immediate reactions after MB-FFP transfusion should be investigated to document the underlying mechanism.
authors.affiliation: Assistance Publique Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Service d'Anesthésie-Réanimation & SAMU de Paris, 149 Rue de Sèvres, Paris, France. pascale.dewachter@yahoo.fr
authors.forename: P
authors.initials: P
authors.lastname: Dewachter
authors.forename: S
authors.initials: S
authors.lastname: Castro
authors.forename: P
authors.initials: P
authors.lastname: Nicaise-Roland
authors.forename: S
authors.initials: S
authors.lastname: Chollet-Martin
authors.forename: C
authors.initials: C
authors.lastname: Le Beller
authors.forename: A
authors.initials: A
authors.lastname: Lillo-le-Louet
authors.forename: C
authors.initials: C
authors.lastname: Mouton-Faivre
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis; D015549:Basophil Degranulation Test / Q000379:methods; D006801:Humans; D008297:Male; D008751:Methylene Blue / Q000009:adverse effects*; D010949:Plasma; D012882:Skin Tests / Q000379:methods; D038301:Virus Inactivation; D055815:Young Adult
chemical_list: D008751:Methylene Blue