title: Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis.
abstract: Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.
authors.affiliation: Department of Small Animal Clinical Sciences, The Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark. aeha@life.ku.dk
authors.forename: A E
authors.initials: AE
authors.lastname: Hansen
authors.forename: A T
authors.initials: AT
authors.lastname: Kristensen
authors.forename: I
authors.initials: I
authors.lastname: Law
authors.forename: J T
authors.initials: JT
authors.lastname: Jørgensen
authors.forename: S A
authors.initials: SA
authors.lastname: Engelholm
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D015687:Cell Hypoxia; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D051793:Hypoxia-Inducible Factor 1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology* / Q000662:veterinary*; D014411:Neoplastic Stem Cells / Q000473:pathology; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051793:Hypoxia-Inducible Factor 1; D035683:MicroRNAs; D000099162:Endothelial PAS Domain-Containing Protein 1