title: L-threonine-derived novel bifunctional phosphine-sulfonamide catalyst-promoted enantioselective aza-Morita-Baylis-Hillman reaction.
abstract: A series of novel bifunctional phosphine-sulfonamide organic catalysts were designed and readily prepared from natural amino acids, and they were utilized to promote enantioselective aza-Morita-Baylis-Hillman (MBH) reactions. L-threonine-derived phosphine-sulfonamide 9b was found to be the most efficient catalyst, affording the desired aza-MBH adducts in high yields and with excellent enantioselectivities.
authors.affiliation: Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Fangrui
authors.initials: F
authors.lastname: Zhong
authors.forename: Youqing
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Han
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Huang
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013912:Threonine / Q000737:chemistry*
chemical_list: D010720:Phosphines; D013449:Sulfonamides; D013912:Threonine; C044646:phosphine