title: A-to-I RNA editing is induced upon hypoxia.
abstract: Regulating gene expression is part of a cell's response to hypoxia. A-to-I RNA editing is an epigenetic phenomenon that can contribute to RNA and protein levels and to isoform diversity. In this study, we identified alterations in the levels of RNA editing following hypoxic stress in three genes: MED13, STAT3, and F11R. Changes in editing levels were associated with changes in RNA levels. These results suggest that A-to-I RNA editing may be one of the mechanisms used by cells to regulate changes in gene expression after hypoxia. These findings could lead to a novel therapeutic approach and better health care for children with hypoxemia.
authors.affiliation: Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Tel Hashomer, Israel. yael.caspi@sheba.health.gov.il
authors.forename: Yael
authors.initials: Y
authors.lastname: Nevo-Caspi
authors.forename: Ninette
authors.initials: N
authors.lastname: Amariglio
authors.forename: Gideon
authors.initials: G
authors.lastname: Rechavi
authors.forename: Gideon
authors.initials: G
authors.lastname: Paret
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000235:genetics; D002460:Cell Line; D003676:Deferoxamine / Q000494:pharmacology; D044127:Epigenesis, Genetic; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D007288:Inosine / Q000096:biosynthesis*; D008297:Male; D056892:Mediator Complex / Q000235:genetics; D017393:RNA Editing; D011956:Receptors, Cell Surface / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000235:genetics
chemical_list: D015815:Cell Adhesion Molecules; C407243:F11R protein, human; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C488666:MED13 protein, human; D056892:Mediator Complex; D011956:Receptors, Cell Surface; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D007288:Inosine; D003676:Deferoxamine; D000241:Adenosine