title: CD4+CD28 null T lymphocytes are expanded in young women with polycystic ovary syndrome.
abstract: Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4(+)CD28(null) T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.
authors.affiliation: Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Niccoli
authors.forename: Rosanna
authors.initials: R
authors.lastname: Apa
authors.forename: Antonio
authors.initials: A
authors.lastname: Lanzone
authors.forename: Giovanna
authors.initials: G
authors.lastname: Liuzzo
authors.forename: Cristina
authors.initials: C
authors.lastname: Spaziani
authors.forename: Francesca
authors.initials: F
authors.lastname: Sagnella
authors.forename: Nicola
authors.initials: N
authors.lastname: Cosentino
authors.forename: Francesca
authors.initials: F
authors.lastname: Moro
authors.forename: Daniela
authors.initials: D
authors.lastname: Martinez
authors.forename: Andrea
authors.initials: A
authors.lastname: Morciano
authors.forename: Marco
authors.initials: M
authors.lastname: Bacà
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pazzano
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Gangale
authors.forename: Anna
authors.initials: A
authors.lastname: Tropea
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D018106:CD28 Antigens / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000276:immunology*; D016022:Case-Control Studies; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood; D007558:Italy; D016014:Linear Models; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000276:immunology*; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018106:CD28 Antigens; D018836:Inflammation Mediators; D002097:C-Reactive Protein