title: Effect of Cuscuta reflexa stem and Calotropis procera leaf extracts on glucose tolerance in glucose-induced hyperglycemic rats and mice.
abstract: Cuscuta reflexa (whole plant) and Calotropis procera (leaves) are used in folk medicine of Bangladesh to control blood sugar in patients suffering from diabetes mellitus. The hypoglycemic effects of methanol and chloroform extracts of whole plants of Cuscuta reflexa, and methanol extract of leaves of Calotropis procera were investigated in oral glucose tolerance tests in Long Evans rats and Swiss albino mice, respectively. Both methanol and chloroform extracts of Cuscuta reflexa whole plant demonstrated significant oral hypoglycemic activity in glucose-loaded rats at doses of 50, 100 and 200 mg/kg body weight. The methanol extract of leaves of Calotropis procera, when tested at doses of 100 and 250 mg/kg body weight did not demonstrate any oral hypoglycemic effect when tested in glucose-loaded mice.
authors.affiliation: Department of Biotechnology & Genetic Engineering, University of Development Alternative, Dhanmondi R/A, Dhaka-1205, Bangladesh. rahamatm@hotmail.com
authors.forename: Mohammed
authors.initials: M
authors.lastname: Rahmatullah
authors.forename: Shamsuddin
authors.initials: S
authors.lastname: Sultan
authors.forename: Tanzila Taher
authors.initials: TT
authors.lastname: Toma
authors.forename: Sayeda-A-Safa
authors.initials: SA
authors.lastname: Lucky
authors.forename: Majeedul H
authors.initials: MH
authors.lastname: Chowdhury
authors.forename: Wahid Mozammel
authors.initials: WM
authors.lastname: Haque
authors.forename: Eashmat Ara
authors.initials: EA
authors.lastname: Annay
authors.forename: Rownak
authors.initials: R
authors.lastname: Jahan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D031107:Calotropis / Q000737:chemistry*; D034182:Cuscuta / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000432:Methanol; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D020318:Rats, Long-Evans; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000432:Methanol