title: Health-related quality of life after aneurysmal subarachnoid hemorrhage: profile and clinical factors.
abstract: BACKGROUND
  Health-related quality of life has recently been suggested as a supplement to the traditional neurological outcome measures from the patient's perspective according to the World Health Organization model and may capture the effects of other factors such as posttraumatic stress disorder and neuroendocrine dysfunction.
  
  
  OBJECTIVE
  To explore the profile and clinical factors of quality of life after aneurysmal subarachnoid hemorrhage using the data we obtained from the recently completed Intravenous Magnesium Sulphate After Aneurysmal Subarachnoid Hemorrhage (IMASH) trial.
  
  
  METHODS
  This study was registered at www.strokecenter.org/trials and www.ClinicalTrials.gov (NCT00124150). Data from a patient cohort obtained with the Short Form-36 questionnaire completed at 6 months were used for analysis.
  
  
  RESULTS
  Patients with aneurysmal subarachnoid hemorrhage demonstrated a decrease in quality of life according to the Short Form-36 at 6 months. The physical and mental health scores correlated with the Extended Glasgow Outcome Scale and had the potential to avoid the ceiling effect. Multiple regression analyses showed that the physical component scores were related to age, World Federation of Neurological Surgeons grade, and chronic hydrocephalus and that the mental component scores were not related to the traditional prognostic factors.
  
  
  CONCLUSIONS
  Subarachnoid hemorrhage caused a decrease in quality of life. Chronic hydrocephalus is related to a decrease in physical health quality of life.
authors.affiliation: Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China. georgewong@surgery.cuhk.edu.hk
authors.forename: George K C
authors.initials: GK
authors.lastname: Wong
authors.forename: Wai S
authors.initials: WS
authors.lastname: Poon
authors.forename: Ronald
authors.initials: R
authors.lastname: Boet
authors.forename: Matthew T V
authors.initials: MT
authors.lastname: Chan
authors.forename: Tony
authors.initials: T
authors.lastname: Gin
authors.forename: Stephanie C P
authors.initials: SC
authors.lastname: Ng
authors.forename: Benny C Y
authors.initials: BC
authors.lastname: Zee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000188:drug therapy; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D008278:Magnesium Sulfate