title: Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus.
abstract: A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also showed antibacterial activity against S. aureus and MRSA.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Republic of Korea.
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Cho
authors.forename: Yun-Ju
authors.initials: YJ
authors.lastname: Kwon
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Sohn
authors.forename: Soon-Ja
authors.initials: SJ
authors.lastname: Seok
authors.forename: Won-Gon
authors.initials: WG
authors.lastname: Kim
mesh_terms: D002396:Catechols / Q000494:pharmacology*; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005658:Fungi / Q000201:enzymology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D011753:Pyrones / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D002396:Catechols; D004791:Enzyme Inhibitors; D011753:Pyrones; C559136:phellinstatin; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)