title: Cyclophosphamide potentiates the antitumor effect of immunization with injection of immature dendritic cells into irradiated tumor.
abstract: Growth of a tumor on the left flank was suppressed by direct injection of immature DCs (iDCs) into the irradiated tumor on the right thigh (IR/DC). This antitumor immune effect of IR/DC was enhanced by pretreatment with CTX (CTX+IR/DC) and this effect was related with increased number of tumor-specific IFN-γ secreting T cells and decreased ratio of CD4(+)CD25(+)/CD4(+) T cells. The treatment with CTX+IR/DC increased or decreased the levels of IL-2 or IL-10, respectively. These results demonstrated that antitumor effect of IR/DC could be augmented by pretreatment with low-dose CTX, suggesting a new antitumor therapeutic modality of chemoradioimmunotherapy.
authors.affiliation: Department of Biochemistry, Pusan National University School of Medicine, Yangsan 626-870, Korea.
authors.forename: You-Soo
authors.initials: YS
authors.lastname: Park
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Bae
authors.forename: Cheol-Hun
authors.initials: CH
authors.lastname: Son
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Wontaek
authors.initials: W
authors.lastname: Kim
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Jung
authors.forename: Kwangmo
authors.initials: K
authors.lastname: Yang
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Chi-Dug
authors.initials: CD
authors.lastname: Kang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D019496:Cancer Vaccines / Q000008:administration & dosage* / Q000276:immunology; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage*; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D007114:Immunization; D007371:Interferon-gamma / Q000096:biosynthesis; D051379:Mice; D008809:Mice, Inbred C3H; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy*; D016499:Radioimmunotherapy; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D007371:Interferon-gamma; D003520:Cyclophosphamide