title: Regulating neutrophil apoptosis: new players enter the game.
abstract: Recently, unexpected biological features of polymorphonuclear neutrophils have been revealed. In addition to their pivotal role in the defence against pathogens, neutrophils display a high degree of plasticity and contribute to control of adaptive immune responses. An emerging aspect of neutrophils is their ability to modulate their survival in response to both intrinsic and extrinsic factors. This review focuses on recent advances that have uncovered proliferating cell nuclear antigen (PCNA) and other cell cycle regulatory proteins as novel players regulating neutrophil survival. A better understanding of the mechanisms involved in neutrophil fate might pave the way for the identification of new anti-inflammatory molecules.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale Unité 1016, 75014 Paris, France. veronique.witko@inserm.fr
authors.forename: Véronique
authors.initials: V
authors.lastname: Witko-Sarsat
authors.forename: Magali
authors.initials: M
authors.lastname: Pederzoli-Ribeil
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsch
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsh
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
authors.forename: Marco A
authors.initials: MA
authors.lastname: Cassatella
mesh_terms: D000818:Animals; D017209:Apoptosis; D002467:Cell Nucleus / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009504:Neutrophils / Q000166:cytology* / Q000276:immunology*; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology
chemical_list: D018809:Proliferating Cell Nuclear Antigen