title: The management of asymptomatic carotid plaque disease: our assumptions when we are less radical.
abstract: The management of asymptomatic carotid artery stenosis (CAS) has been the subject of extensive debate. Current evidence suggests that the annual risk of stroke in patients with CAS and without previous cerebrovascular symptoms is 1% which makes carotid endarterectomy unjustifiable. Conservative treatment with statins and antiplatelets, the identification of the high risk individuals as well as aggressive life style modifications are considered sufficient measures for the protection of these patients. However, there are reasons to believe that this approach may be less effective than we think. Best medical treatment is only effective when compliance is adequate and lipid or blood pressure target levels are achieved. However this is not always the case and the same applies regarding life style modification changes such as smoking. In addition, there is no consensus regarding the identification of the high risk individuals despite recent encouraging evidence. The introduction of a structured network of risk factor modification clinics in conjunction with the vascular clinics and the identification of ways to objectively risk-stratify patients with asymptomatic CAS could enable us to optimize the management of these patients when we decide to be less radical.
authors.affiliation: Division of Surgery, Imperial College of London, London, UK. g.makris09@imperial.ac.uk
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Makris
authors.forename: Andrew
authors.initials: A
authors.lastname: Nicolaides
authors.forename: George
authors.initials: G
authors.lastname: Geroulakos
mesh_terms: D058070:Asymptomatic Diseases; D016893:Carotid Stenosis / Q000628:therapy*; D006801:Humans