title: Landscape mapping of functional proteins in insulin signal transduction and insulin resistance: a network-based protein-protein interaction analysis.
abstract: The type 2 diabetes has increased rapidly in recent years throughout the world. The insulin signal transduction mechanism gets disrupted sometimes and it's known as insulin-resistance. It is one of the primary causes associated with type-2 diabetes. The signaling mechanisms involved several proteins that include 7 major functional proteins such as INS, INSR, IRS1, IRS2, PIK3CA, Akt2, and GLUT4. Using these 7 principal proteins, multiple sequences alignment has been created. The scores between sequences also have been developed. We have constructed a phylogenetic tree and modified it with node and distance. Besides, we have generated sequence logos and ultimately developed the protein-protein interaction network. The small insulin signal transduction protein arrangement shows complex network between the functional proteins.
authors.affiliation: School of Bioscience and Technology, VIT University, Vellore, India.
authors.forename: Chiranjib
authors.initials: C
authors.lastname: Chakraborty
authors.forename: Sanjiban S
authors.initials: SS
authors.lastname: Roy
authors.forename: Minna J
authors.initials: MJ
authors.lastname: Hsu
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Agoramoorthy
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D020407:Internet; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D010802:Phylogeny; D025941:Protein Interaction Mapping / Q000379:methods*; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007328:Insulin; D047908:Intracellular Signaling Peptides and Proteins