title: Early treatment of a progressive Rasmussen's like syndrome with ganciclovir.
abstract: BACKGROUND
  Escalating focal sensorimotor seizures, progressive neurologic deficit and cognitive decline with associated typical magnetic resonance imaging (MRI) findings or pathological confirmation constitute the syndrome of Rasmussen's encephalitis.
  
  
  METHODS
  Three patients with this clinical scenario had long-term follow-up after being given the antiviral drug ganciclovir 10 mg/kg/day IV for ten days within one to three months of disease onset.
  
  
  RESULTS
  Seizures occurred at least hourly and were localized to the Rolandic region. The MRIs were normal in one patient and in two showed changes consistent with ongoing seizures. Two patients, one whose short-term outcome was reported previously, had immediate and sustained cessation of seizures and resolution of their neurologic deficit. One patient with seizures from both hemispheres did not respond and went on to hemispherectomy that confirmed chronic encephalitis. Seizures continued in five other patients treated 6 to 72 months after disease onset.
  
  
  CONCLUSIONS
  The sustained seizure control after ganciclovir in two of three patients suggests this drug may be effective when given early in the course of this subacute intractable focal epilepsy syndrome.
authors.affiliation: Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
authors.forename: Richard S
authors.initials: RS
authors.lastname: McLachlan
authors.forename: David
authors.initials: D
authors.lastname: Diosy
authors.forename: Simon
authors.initials: S
authors.lastname: Levin
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir