title: Serum magnesium concentrations and metabolic variables in polycystic ovary syndrome.
abstract: OBJECTIVE
  Hypomagnesemia is associated with diabetes mellitus type 2 and other components of the metabolic syndrome in older patients. Whether serum magnesium concentrations correlate with insulin resistance, obesity, hypertension, dyslipidemia, or other components of metabolic syndrome in younger women with polycystic ovary syndrome (PCOS) is currently unknown.
  
  
  METHODS
  Cross-sectional analysis.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  100 consecutive women with PCOS by the Rotterdam criteria and 20 age- and BMI-matched normal women.
  
  
  METHODS
  Statistical analysis of the relationship between magnesium levels and a variety of physical, endocrine, and metabolic variables. The STROBE guidelines for a cross-sectional analysis were followed.
  
  
  METHODS
  Serum magnesium levels, insulin sensitivity indices, and glucose assessments. BMI, waist circumference, blood pressure, and lipids served as secondary endpoint measurements.
  
  
  RESULTS
  No patient demonstrated hypomagnesemia. Magnesium levels did not differ between women with and those without insulin resistance, glucose intolerance, or hypertension. Magnesium levels were similar across PCOS phenotypes and WHO-defined BMI categories. Multiple regression analysis did not suggest that serum magnesium concentrations correlated with any physical, metabolic, or endocrine variable.
  
  
  CONCLUSIONS
  Magnesium levels do not correspond with age, BMI, waist circumference, insulin sensitivity, glycemic levels, blood pressure, or lipid levels in reproductive-age women with PCOS. Magnesium concentrations are similar across PCOS phenotypes and indistinguishable from women without PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center School of Medicine, Amarillo, USA. robert.kauffman@ttuhsc.edu
authors.forename: Robert P
authors.initials: RP
authors.lastname: Kauffman
authors.forename: Paul E
authors.initials: PE
authors.lastname: Tullar
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Nipp
authors.forename: V Daniel
authors.initials: VD
authors.lastname: Castracane
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008274:Magnesium / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011446:Prospective Studies; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids; D008274:Magnesium