title: A skin-contact-actuated micropump for transdermal drug delivery.
abstract: In this paper, a skin-contact-actuated dispenser/micropump for transdermal drug delivery applications is presented. The micropump consists of stacked polydimethylsiloxane layers mounted on a silicon substrate and operates based on the evaporation and condensation of a low-boiling-point liquid. Therefore, there is no need for a heater and a power source, since only the thermal energy provided by skin contact is required for the actuation. A prototype device with overall dimensions of 14 mm × 14 mm × 8 mm is fabricated and characterized. For a perfluoro compound working fluid (3M FC-3284), a flow rate of 28.8 μ L/min and a maximum back pressure of 28.9 kPa is measured.
authors.affiliation: School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47906, USA. cmousoul@purdue.edu
authors.forename: Charilaos
authors.initials: C
authors.lastname: Mousoulis
authors.forename: Manuel
authors.initials: M
authors.lastname: Ochoa
authors.forename: Demetrios
authors.initials: D
authors.lastname: Papageorgiou
authors.forename: Babak
authors.initials: B
authors.lastname: Ziaie
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002645:Chickens; D004129:Dimethylpolysiloxanes; D004867:Equipment Design; D006801:Humans; D007260:Infusion Pumps; D044085:Microfluidics / Q000295:instrumentation*; D009757:Nylons; D012879:Skin Physiological Phenomena; D013696:Temperature
chemical_list: D004129:Dimethylpolysiloxanes; D009757:Nylons; C085707:poly(dimethylsiloxane)-polyamide copolymer