title: Allogeneic haematopoietic cell transplantation for myelofibrosis in 30 patients 60-78 years of age.
abstract: We analysed the results of haematopoietic cell transplantation (HCT) in 30 patients aged 60-78 (median 65) years, with primary myelofibrosis or myelofibrosis evolving from antecedent polycythaemia vera or essential thrombocythaemia. Donors were human leucocyte antigen (HLA)-identical siblings (N = 15) or unrelated individuals (N = 15). Various conditioning regimens were used, ranging from very low intensity (fludarabine plus 2 Gy total body irradiation) to high dose (busulfan plus cyclophosphamide). Stem cell sources were granulocyte colony-stimulating factor mobilized peripheral blood progenitor cells in 29 patients and marrow in one patient. Sustained engraftment was documented in 27 of 30 patients. Day -100 mortality was 13%. With a median follow-up of 22 (range 0·5 - 69) months, 3-year overall survival and progression-free survival were 45% and 40%, respectively. Currently, 13 patients are surviving. Seven patients died with disease progression at 0·5 -22 months, and 10 patients died from other causes at 1·5 -37.5 months after HCT. While the selection of older patients for transplantation was probably biased, the present results are encouraging. Motivated older patients with myelofibrosis without substantial comorbid conditions should be offered the option of allogeneic HCT.
authors.affiliation: University of Utah, Department of Medicine, Salt Lake City, UT, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Samuelson
authors.forename: Brenda M
authors.initials: BM
authors.lastname: Sandmaier
authors.forename: Helen E
authors.initials: HE
authors.lastname: Heslop
authors.forename: Uday
authors.initials: U
authors.lastname: Popat
authors.forename: George
authors.initials: G
authors.lastname: Carrum
authors.forename: Richard E
authors.initials: RE
authors.lastname: Champlin
authors.forename: Rainer
authors.initials: R
authors.lastname: Storb
authors.forename: Josef T
authors.initials: JT
authors.lastname: Prchal
authors.forename: Theodore A
authors.initials: TA
authors.lastname: Gooley
authors.forename: H Joachim
authors.initials: HJ
authors.lastname: Deeg
mesh_terms: D000367:Age Factors; D000368:Aged; D004812:Epidemiologic Methods; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000628:therapy*; D012008:Recurrence; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome