title: Late outcomes of drug eluting and bare metal stents in saphenous vein graft percutaneous coronary intervention.
abstract: OBJECTIVE
  PCI with drug eluting stents (DES) has been shown to reduce restenosis and major adverse cardiac event (MACE) rates compared to bare metal stents (BMS) in native coronary vessels, although outcomes in saphenous vein graft (SVG) lesions are less clear. We retrospectively studied 388 consecutive patients admitted to our centre for SVG PCI to assess mortality and MACE outcomes (defined as composite endpoint of all-death, stroke, myocardial infarction, stent thrombosis and target lesion (TLR)/vessel (TVR) revascularisation) associated with BMS and DES use.
  
  
  RESULTS
  Two hundred and nineteen (219) patients had BMS and 169 had DES (total 388 patients). Mean follow up was 41.9±23.5 months. No significant differences were observed in mortality (14.2% vs. 11.8%) or MACE (37.6% vs. 35.8%) between the BMS and DES groups at four years follow-up or at other intervening time points studied. Similarly, no differences in TVR/TLR rates were observed over a similar time period (19.8% vs. 21.6%).
  
  
  CONCLUSIONS
  We have observed that DES and BMS use in SVG PCI have comparable mortality and MACE rates, and that in contrast to PCI in native coronary arteries, DES do not reduce revascularisation rates in our study cohort.
authors.affiliation: Manchester Heart Centre, Manchester Royal Infirmary, Biomedical Research Centre, and Manchester Academic Health Science Center, University of Manchester, Manchester, United Kingdom.
authors.forename: Satheesh
authors.initials: S
authors.lastname: Nair
authors.forename: Farzin
authors.initials: F
authors.lastname: Fath-Ordoubadi
authors.forename: Bernard
authors.initials: B
authors.lastname: Clarke
authors.forename: Magdi
authors.initials: M
authors.lastname: El-Omar
authors.forename: James
authors.initials: J
authors.lastname: Foley
authors.forename: Doug G
authors.initials: DG
authors.lastname: Fraser
authors.forename: Vaikom S
authors.initials: VS
authors.lastname: Mahadevan
authors.forename: Ludwig
authors.initials: L
authors.lastname: Neyses
authors.forename: Raj S
authors.initials: RS
authors.lastname: Khattar
authors.forename: Mamas A
authors.initials: MA
authors.lastname: Mamas
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000401:mortality*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000401:mortality* / Q000628:therapy*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008670:Metals; D008875:Middle Aged; D019233:Retreatment / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D012501:Saphenous Vein / Q000637:transplantation*; D016896:Treatment Outcome
chemical_list: D008670:Metals