title: Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients.
abstract: Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We studied 160 hypertensive patients and 123 healthy controls. Echocardiography was performed in all patients and the C(-1306)T (rs243865) and C(-735)T (rs 2285053) MMP-2 polymorphisms were analysed. Haplo.stats analysis was used to evaluate whether MMP-2 haplotypes are associated with hypertension and with extremes in LV mass index (LVMI). Multiple linear regression analysis was performed to assess whether MMP-2 genotypes or haplotypes affect LVMI and other echocardiography parameters. The C(-1306)T 'CC' genotype was associated with reduced LVMI and LV end-diastolic diameter (EDD) (P=0.0365 and P=0.0438, respectively). The haplotype 'C, C' was associated with reduced LVMI and EDD (P=0.0278 and P=0.0322, respectively). The comparison of upper and lower extremes of the LVMI phenotype showed that the 'C, C' haplotype was more common in the lower LVMI group (P=0.0060), whereas the 'T, C' haplotype was more common in the higher quartile of LVMI (P=0.0187), and this haplotype was associated with increased risk of higher LVMI values (odds ratio=3.5121, 95% confidence interval=1.3193-9.3494). The findings suggest that MMP-2 polymorphisms affect hypertension-induced LV remodelling.
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Lacchini
authors.forename: A L B
authors.initials: AL
authors.lastname: Jacob-Ferreira
authors.forename: M R
authors.initials: MR
authors.lastname: Luizon
authors.forename: S
authors.initials: S
authors.lastname: Gasparini
authors.forename: M C S
authors.initials: MC
authors.lastname: Ferreira-Sae
authors.forename: R
authors.initials: R
authors.lastname: Schreiber
authors.forename: W
authors.initials: W
authors.lastname: Nadruz
authors.forename: J E
authors.initials: JE
authors.lastname: Tanus-Santos
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D005260:Female; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020257:Ventricular Remodeling / Q000235:genetics*
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2