title: New lessons from random X-chromosome inactivation in the mouse.
abstract: X-chromosome inactivation (XCI) ensures dosage compensation in mammals. Random XCI is a process where a single X chromosome is silenced in each cell of the epiblast of mouse female embryos. Operating at the level of an entire chromosome, XCI is a major paradigm for epigenetic processes. Here we review the most recent discoveries concerning the role of long noncoding RNAs, pluripotency factors, and chromosome structure in random XCI.
authors.affiliation: Génétique Moléculaire Murine, Department of Developmental Biology, CNRS URA2578, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Clerc
authors.forename: Philip
authors.initials: P
authors.lastname: Avner
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D049951:X Chromosome Inactivation
chemical_list: D022661:RNA, Untranslated