title: Mediator and post-recruitment regulation of RNA polymerase II.
abstract: The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Knuesel
authors.forename: Dylan J
authors.initials: DJ
authors.lastname: Taatjes
mesh_terms: D006801:Humans; D056892:Mediator Complex / Q000737:chemistry / Q000378:metabolism*; D056913:Mediator Complex Subunit 1 / Q000737:chemistry / Q000378:metabolism*; D008957:Models, Genetic; D009154:Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics; D011485:Protein Binding; D011487:Protein Conformation; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism*; D015534:Trans-Activators; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: C538855:MED1 protein, human; C538713:Med17 protein, human; D056892:Mediator Complex; D056913:Mediator Complex Subunit 1; D021122:Protein Subunits; D015534:Trans-Activators; D016159:Tumor Suppressor Protein p53; D012319:RNA Polymerase II