title: A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity.
abstract: Curcumin (CUR) is an active food compound, but its insolubility and instability in water contributes to low bioavailability. In this study, the solubility of CUR was enhanced by utilizing the solubilizing properties of rubusoside (RUB). The solubility of CUR in water increased linearly from 61 μg/mL to 2.318 mg/mL in the presence of RUB ranging from 1% to 10% (w/v). Dynamic light scattering and transmission electron microscopy studies found that CUR and RUB formed CUR-RUB nanoparticle (∼8 nm) complexes. The RUB-solubilized CUR was stable in physiological conditions and did not precipitate when diluted or degrade when spray-dried to a completely reconstitutable powder. Furthermore, cell viability assays demonstrated the efficacy of RUB-solubilized CUR against human colon, breast, and pancreatic cancer cell lines. The development of this new solubilized, stable, and biologically active CUR formulation lays the foundation for future bioavailability improvement.
authors.affiliation: School of Renewable Natural Resources, Louisiana State University Agricultural Center, Baton Rouge, Louisiana 70803, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Gar Yee
authors.initials: GY
authors.lastname: Koh
authors.forename: Duane P
authors.initials: DP
authors.lastname: Jeansonne
authors.forename: Javoris
authors.initials: J
authors.lastname: Hollingsworth
authors.forename: Paul S
authors.initials: PS
authors.lastname: Russo
authors.forename: Graca
authors.initials: G
authors.lastname: Vicente
authors.forename: Rhett W
authors.initials: RW
authors.lastname: Stout
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry*; D004339:Drug Compounding; D004355:Drug Stability; D005960:Glucosides / Q000737:chemistry*; D019073:HT29 Cells; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008027:Light; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D053758:Nanoparticles; D011208:Powders; D012542:Scattering, Radiation; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D005960:Glucosides; D011208:Powders; D012997:Solvents; D014867:Water; D003474:Curcumin; C056177:rubusoside