title: Development of a novel oral vaccine against Mycobacterium avium paratuberculosis and Johne disease: a patho-biotechnological approach.
abstract: Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne disease, a granulomatous enteritis of cattle and other domesticated and wild ruminant species. Johne disease is prevalent worldwide and has a significant impact on the global agricultural economy. Current vaccines against Johne are insufficient in stemming its spread, and associated side-effects prevent their widespread use in control programs. Effective and safe vaccine strategies are needed. The main purpose of this paper is to propose and evaluate the development of a novel oral subunit-vaccine using a patho-biotechnological approach. This novel strategy, which harnesses patho-genetic elements from the intracellular pathogen Listeria monocytogenes, may provide a realistic route towards developing an effective next generation subunit vaccine against Johne disease and paratuberculosis.
authors.affiliation: Cork Institute of Technology, Bishopstown, Cork, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Johnston
authors.forename: A
authors.initials: A
authors.lastname: Coffey
authors.forename: Jim
authors.initials: J
authors.lastname: O' Mahony
authors.forename: R D
authors.initials: RD
authors.lastname: Sleator
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001709:Biotechnology / Q000379:methods; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D005818:Genetic Engineering; D008089:Listeria monocytogenes / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D016927:Mycobacterium avium subsp. paratuberculosis / Q000235:genetics* / Q000276:immunology*; D010283:Paratuberculosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines