title: Wound complications after gynecologic cancer surgery.
abstract: OBJECTIVE
  To explore clinical correlates of wound complications in high-risk women undergoing abdominal gynecologic surgery in a tertiary referral center.
  
  
  METHODS
  Retrospective analysis of patient demographics, pre-operative and intra-operative information, and outcomes was performed in a cohort of patients who underwent abdominal surgery for suspected gynecologic malignancy between 1/2005 and 6/2008. The primary outcome was wound complication within 6 weeks of surgery. Univariate and multivariate logistic regression analyses were employed. A nomogram predicting post-operative wound complications was created and validated by receiver operating characteristic (ROC) curve analysis and 10-fold cross-validation.
  
  
  RESULTS
  Median age of 373 women analyzed was 57years (range 25-88), median body mass index (BMI) 32.3kg/m(2) (range 14.0-70.7). A total of 150 patients (40%) had prior abdominal surgery; 40 (11%) had a pre-operative serum albumin <3.5g/dl; and 78 (21%) had pulmonary disease. Wound complications occurred in 125 patients (34%). In multivariate analysis wound complications were correlated with BMI of 30-39.9kg/m(2) (OR=5.62, 95% CI 2.08-15.19, p<0.0001) and BMI≥40kg/m(2) (OR=10.27, 95% CI 3.66-28.88, p<0.0001), prior abdominal surgery (OR 3.28, 95%CI1.89-5.70, p<0.0001), serum albumin≤3.5g/dl (OR 4.24, 95%CI 1.87-9.61, p=0.0005), pulmonary disease (OR 2.22, 95%CI 1.09-4.51, p=0.03), lysis of adhesions (OR 3.57, 95%CI 1.04-12.26, p=0.04), and length of surgery (OR 2.42, 95%CI 1.35-4.35, p=0.003). Risk for wound complication was lower with pelvic drain placement (OR 0.26, 95%CI 0.11-0.64, p=0.003).
  
  
  CONCLUSIONS
  Wound complications are common in gynecologic oncology. Further studies should explore whether risk factor modification decreases complications.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Barnes-Jewish Hospital and Siteman Cancer Center, St. Louis, MO 63110, USA.
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Nugent
authors.forename: John T
authors.initials: JT
authors.lastname: Hoff
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: L Stewart
authors.initials: LS
authors.lastname: Massad
authors.forename: Ashley
authors.initials: A
authors.lastname: Case
authors.forename: Israel
authors.initials: I
authors.lastname: Zighelboim
authors.forename: David G
authors.initials: DG
authors.lastname: Mutch
authors.forename: Premal H
authors.initials: PH
authors.lastname: Thaker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery*; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D007813:Laparotomy / Q000009:adverse effects; D008875:Middle Aged; D008923:Missouri / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D012189:Retrospective Studies