title: SAR studies on dihydropyrimidinone antibiotics.
abstract: There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing favorable selectivity were identified.
authors.affiliation: Gilead Sciences Inc., Foster City, CA 94404, USA. lianhong.xu@gilead.com
authors.forename: Lianhong
authors.initials: L
authors.lastname: Xu
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
authors.forename: Robert
authors.initials: R
authors.lastname: Jones
authors.forename: Clifford
authors.initials: C
authors.lastname: Bryant
authors.forename: Nina
authors.initials: N
authors.lastname: Boddeker
authors.forename: Eric
authors.initials: E
authors.lastname: Mabery
authors.forename: Gina
authors.initials: G
authors.lastname: Bahador
authors.forename: Julia
authors.initials: J
authors.lastname: Watson
authors.forename: Jeffery
authors.initials: J
authors.lastname: Clough
authors.forename: Murty
authors.initials: M
authors.lastname: Arimilli
authors.forename: Wendy
authors.initials: W
authors.lastname: Gillette
authors.forename: Dorothy
authors.initials: D
authors.lastname: Colagiovanni
authors.forename: Keyu
authors.initials: K
authors.lastname: Wang
authors.forename: Craig
authors.initials: C
authors.lastname: Gibbs
authors.forename: Choung U
authors.initials: CU
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines