title: Identification of a natural human serotype 3 parainfluenza virus.
abstract: Parainfluenza virus is an important pathogen threatening the health of animals and human, which brings human many kinds of disease, especially lower respiratory tract infection involving infants and young children. In order to control the virus, it is necessary to fully understand the molecular basis resulting in the genetic diversity of the virus. Homologous recombination is one of mechanisms for the rapid change of genetic diversity. However, as a negative-strand virus, it is unknown whether the recombination can naturally take place in human PIV. In this study, we isolated and identified a mosaic serotype 3 human PIV (HPIV3) from in China, and also provided several putative PIV mosaics from previous reports to reveal that the recombination can naturally occur in the virus. In addition, two swine PIV3 isolates transferred from cattle to pigs were found to have mosaic genomes. These results suggest that homologous recombination can promote the genetic diversity and potentially bring some novel biologic characteristics of HPIV.
authors.affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China.
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Yang
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
authors.forename: Xu
authors.initials: X
authors.lastname: Zhou
authors.forename: Mu-Qun
authors.initials: MQ
authors.lastname: Bai
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Si
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Heng
authors.initials: H
authors.lastname: Zhao
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: He
authors.forename: Cheng-Qiang
authors.initials: CQ
authors.lastname: He
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000635:transmission / Q000821:virology; D002681:China; D016000:Cluster Analysis; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008969:Molecular Sequence Data; D029101:Parainfluenza Virus 3, Bovine / Q000302:isolation & purification; D010224:Parainfluenza Virus 3, Human / Q000145:classification* / Q000302:isolation & purification*; D018184:Paramyxoviridae Infections / Q000662:veterinary* / Q000821:virology*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D012703:Serotyping; D013552:Swine; D013553:Swine Diseases / Q000635:transmission / Q000821:virology
chemical_list: D012367:RNA, Viral