title: Bioavailability and efficacy of vitamin D2 from UV-irradiated yeast in growing, vitamin D-deficient rats.
abstract: New food sources are needed to bridge the gap between vitamin D intake and recommended intake. We assessed the bioavailability and efficacy of vitamin D in an 8 week dose-response study of bread made with vitamin D2-rich yeast compared to vitamin D3 in growing, vitamin D-deficient rats. Plasma 25-hydroxyvitamin D (25OHD) levels increased in a curvilinear, dose-dependent manner with both forms of vitamin D, but rats fed vitamin D2-rich yeast achieved lower levels than rats fed vitamin D3. Rats fed the highest doses of vitamin D had significantly greater (p<0.05) trabecular BMC, BMD, bone volume, and connectivity density, and greater midshaft total cross-sectional area, compared to rats on the vitamin D-deficient diets, with no significant difference due to vitamin D source. Vitamin D2-rich yeast baked into bread is bioavailable and improves bone quality in vitamin D-deficient animals.
authors.affiliation: Department of Foods & Nutrition, 700 W. State Street, Purdue University, West Lafayette, Indiana 47907, United States.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Hohman
authors.forename: Berdine R
authors.initials: BR
authors.lastname: Martin
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Lachcik
authors.forename: Dennis T
authors.initials: DT
authors.lastname: Gordon
authors.forename: James C
authors.initials: JC
authors.lastname: Fleet
authors.forename: Connie M
authors.initials: CM
authors.lastname: Weaver
mesh_terms: D000818:Animals; D001682:Biological Availability; D001846:Bone Development / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D001939:Bread / Q000032:analysis / Q000382:microbiology; D004195:Disease Models, Animal; D004872:Ergocalciferols / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012441:Saccharomyces cerevisiae / Q000378:metabolism* / Q000528:radiation effects; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D004872:Ergocalciferols; D014807:Vitamin D; C104450:25-hydroxyvitamin D