title: Sphincter of Oddi manometry by choledochoscope in patients with duodenobiliary reflux.
abstract: OBJECTIVE
  Previous research has confirmed that duodenobiliary reflux exists in patients with choledocholithiasis. The objective of this study was to investigate whether the motor activity of the sphincter of Oddi (SO) has an effect on duodenobiliary reflux.
  
  
  METHODS
  A total of 51 patients orally ingested 1mL water containing technetium-99m diethylenetriaminepentaacetatic acid, and a 2-h bile collection was obtained from the T tube. Technetium counts in the collected bile were performed using an RM905 radioactivity meter. The patients were divided into two groups: reflux group (duodenobiliary reflux positive) and control group (duodenobiliary reflux negative). Next, 33 cases were randomly selected and double blinded to receive SO manometry by choledochoscope.
  
  
  RESULTS
  Of the 51 total cases, 16 bile samples exhibited radioactivity. The average SO basal pressure and contraction pressure values were 7.2±3.9mmHg and 53.5±24.5mmHg, respectively, in the reflux group, and 14.7±11.0mmHg and 117.2±65.6mmHg, respectively, in the control group. The choledochus pressure values were 5.1±1.6mmHg and 11.5±7.4mmHg in the reflux group and the control group, respectively. The differences between the groups were statistically significant; however, the SO contraction frequency, SO contraction duration, and duodenum pressure values were not significantly different between the groups.
  
  
  CONCLUSIONS
  The decreases in the SO basal pressure and SO contraction pressure, and the decrease in choledochus pressure, might play a role in duodenobiliary reflux.
authors.affiliation: Department of Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Shaolong
authors.initials: S
authors.lastname: Sun
authors.forename: Shuodong
authors.initials: S
authors.lastname: Wu
authors.forename: Dongxu
authors.initials: D
authors.lastname: Cui
authors.forename: Baolin
authors.initials: B
authors.lastname: Liu
authors.forename: Xianwei
authors.initials: X
authors.lastname: Dai
authors.forename: Weina
authors.initials: W
authors.lastname: Xu
authors.forename: Shupeng
authors.initials: S
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D042883:Choledocholithiasis / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D004311:Double-Blind Method; D004322:Drainage; D004383:Duodenogastric Reflux / Q000175:diagnosis* / Q000503:physiopathology; D019723:Endoscopes; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000295:instrumentation*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011312:Pressure; D019275:Radiopharmaceuticals; D018570:Risk Assessment; D012307:Risk Factors; D009803:Sphincter of Oddi / Q000503:physiopathology*; D046628:Sphincter of Oddi Dysfunction / Q000175:diagnosis* / Q000503:physiopathology; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate