title: Fixing the model for transcription: the DNA moves, not the polymerase.
abstract: The traditional model for transcription sees active polymerases tracking along their templates. An alternative (controversial) model has active enzymes immobilized in "factories." Recent evidence supports the idea that the DNA moves, not the polymerase, and points to alternative explanations of how regulatory motifs like enhancers and silencers work.
authors.affiliation: University of Oxford, UK.
authors.forename: Argyris
authors.initials: A
authors.lastname: Papantonis
authors.forename: Peter R
authors.initials: PR
authors.lastname: Cook
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D013698:Templates, Genetic; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D004247:DNA; D012321:DNA-Directed RNA Polymerases