title: Parvovirus among patients with cytopenia of unknown origin in Brazil: a case-control study.
abstract: The molecular prevalence of human parvovirus B19V (B19V) in bone marrow (BM) samples from 120 cases with cytopenias of unknown etiology was compared with that in samples from 45 BM donors (control group 1) and 120 oncohematological patients (control group 2) to determine the role that B19V genotypes may play in unexplained cytopenias. Of the 285 participants, the BM samples of 39 (13.7%) contained B19V DNA (21 with genotype 1, 5 with genotype 2, and 13 with genotype 3). The prevalences of B19V were similar between case and control subjects (15.0% versus 12.7%, respectively). Genotypes 2 and 3 were associated with older age and were detected in similar proportions between case and control group 2 subjects. The results of this study do not support a role for B19V genotype variants in the etiology of unexplained cytopenias.
authors.affiliation: Department of Hematology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Sheila de Oliveira
authors.initials: Sde O
authors.lastname: Garcia
authors.forename: Walter
authors.initials: W
authors.lastname: Kleine Neto
authors.forename: Antonio Charlys
authors.initials: AC
authors.lastname: da Costa
authors.forename: Sabri Saeed
authors.initials: SS
authors.lastname: Sanabani
authors.forename: Alfredo
authors.initials: A
authors.lastname: Mendrone
authors.forename: Juliana
authors.initials: J
authors.lastname: Pereira
authors.forename: Ester Cerdeira
authors.initials: EC
authors.lastname: Sabino
mesh_terms: D000328:Adult; D000740:Anemia / Q000821:virology; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D016000:Cluster Analysis; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000453:epidemiology* / Q000473:pathology; D017992:Parvovirus / Q000302:isolation & purification*; D015995:Prevalence; D017422:Sequence Analysis, DNA
chemical_list: D004279:DNA, Viral