title: Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus.
abstract: To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarusian men aged 45-65 years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, and triglyceride concentrations were assessed, and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A(1c), immune-reactive insulin (IRI), serum total testosterone, and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r = 0.23, P = 0.002) and leptin (r = 0.21, P = 0.006). By multivariate regression analysis adjusting for confounding factors, log leptin was independently correlated with BMD (β = 0.058, P = 0.001). Our study revealed that leptin is an independent determinant of BMD in patients with T2DM. Further research is necessary to confirm this association and to develop ways to correct abnormalities of bone metabolism in patients with T2DM.
authors.affiliation: Department of Public Health, Gomel State Medical University, Gomel, Belarus.|The Republican Research Centre for Radiation Medicine and Human Ecology, Gomel, Belarus.
authors.forename: Olga
authors.initials: O
authors.lastname: Vasilkova
authors.affiliation: Department of Internal Medicine, Belarussian State Medical University, Minsk, Belarus.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Mokhort
authors.affiliation: Department of Public Health, Gomel State Medical University, Gomel, Belarus.
authors.forename: Tamara
authors.initials: T
authors.lastname: Sharshakova
authors.affiliation: Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 8528523, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Hayashida
authors.affiliation: Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 8528523, Japan. takamura@nagasaki-u.ac.jp.
authors.forename: Noboru
authors.initials: N
authors.lastname: Takamura
mesh_terms: D000368:Aged; D015519:Bone Density; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D006442:Glycated Hemoglobin; D020738:Leptin; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL