title: Transfection assays for transformation of model colonic cell lines.
abstract: The recognition of cancer as a genetic disease has changed the approach investigators take to understanding the mechanisms of carcinogenesis. The discovery of oncogenes, and the recognition of the inactivation of tumor suppressor genes, DNA repair enzymes, and of apoptotic pathways have provided a clearer picture of the dysregulation which is required for a cell to become a cancer.
authors.affiliation: Department of Medicine/GI, University of Virginia Health System, Charlottesville, VA.
authors.forename: M T
authors.initials: MT
authors.lastname: Worthington
authors.forename: R Q
authors.initials: RQ
authors.lastname: Luo