title: Absorption of 10-hydroxycamptothecin on Fe3O4 magnetite nanoparticles with layer-by-layer self-assembly and drug release response.
abstract: In this paper, the structural and zeta potential properties of 10-hydroxycamptothecin (HCPT) were investigated by FT-IR and zeta potential analyzer under different pH. The anticancer drug HCPT as a model drug was used to prepare a high-performance and relatively easy-to-fabricate system on Fe(3)O(4) magnetite nanoparticles by using a polystyrene sulfonate (PSS) and HCPT interlayer self-assembly method. The results obtained from FT-IR and XRD confirmed that HCPT was molecularly dispersed into the nanoparticles. The method holds not only environment-friendly characteristics and the ability to mimic the self-organization process in biological systems but also greatly decreases adjuvant polymers. In addition, the system has an ideal drug payload for the delivery of insoluble HCPTs.
authors.affiliation: School of Materials Science and Engineering, Harbin Institute of Technology, Heilongjiang, 150001, China. ximing.guo@yahoo.com.cn
authors.forename: Xi Ming
authors.initials: XM
authors.lastname: Guo
authors.forename: Bin
authors.initials: B
authors.lastname: Guo
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Sun
mesh_terms: D000042:Absorption; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D011137:Polystyrenes; C003321:polystyrene sulfonic acid; C028098:10-hydroxycamptothecin; D052203:Ferrosoferric Oxide; D002166:Camptothecin