title: Arabinogalactan present in the mountain celery seed extract potentiated hypolipidemic bioactivity of coexisting polyphenols in hamsters.
abstract: BACKGROUND
  Previously, we showed the essential oils (EO) of the mountain celery [Cryptotaenia japonica Hass (Umbelliferae)] seeds (MCS) to be a prominent hypolipidemic agent.
  
  
  OBJECTIVE
  We hypothesized the aqueous extract (AE) of its seeds could also exhibit a comparable nutritional effect.
  
  
  METHODS
  Experiments were carried out for compositional analysis, antioxidant assay, and hypolipidaemic assay with AE in hamsters.
  
  
  RESULTS
  AE contained soluble arabinogalactan (AGal) with molecular weight (MW) 878 kDa. AE also was enriched in polyphenolics and flavonoids, reaching 30.4 and 2.20 mg/100 g, respectively. AGal consisted of eight monosaccharides (in mols %), galactose (28.75), arabinose (24.84), glucose (17.91), mannose (6.93), ribose (6.03), fucose (5.83), xylose (5.30), and rhamnose (4.41), with average MW 878 kDa. In vitro, AE showed potent ferrous chelating and DPPH scavenging effects but only moderate H₂O₂ scavenging capability. In hamsters, AE exhibited promising hypolipidemic bioactivity, in particular, the HDL-C and hepatic unsaturated fatty acid (UFA) biosynthesis regarding oleic, linoleic, and arachidonic acids.
  
  
  CONCLUSIONS
  The presence of AGal enhanced the hypolipidemic and antioxidative bioactivity of MCS. MCS is feasibly beneficial to the hepatic de novo UFA synthesis and the hypolipidemics as evidenced by hamster model.
authors.affiliation: Department of Food and Nutrition, Research Institute of Biotechnology, Hungkuang University, Taichung Hsien, Taiwan 43302.
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Lin
authors.forename: Yaw-Bee
authors.initials: YB
authors.lastname: Ker
authors.forename: Chi-Huan
authors.initials: CH
authors.lastname: Chang
authors.forename: Kuan-Chou
authors.initials: KC
authors.lastname: Chen
authors.forename: Robert Y
authors.initials: RY
authors.lastname: Peng
mesh_terms: D000818:Animals; D000077102:Apium; D006224:Cricetinae; D004357:Drug Synergism; D005227:Fatty Acids / Q000378:metabolism; D005685:Galactans / Q000302:isolation & purification* / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000302:isolation & purification* / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D010936:Plant Extracts / Q000302:isolation & purification* / Q000378:metabolism; D059808:Polyphenols / Q000302:isolation & purification* / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification* / Q000378:metabolism; D011897:Random Allocation; D012639:Seeds
chemical_list: D005227:Fatty Acids; D005685:Galactans; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D059808:Polyphenols; D011135:Polysaccharides, Bacterial; C005653:arabinogalactan