title: [Preparation of zoledronic-acid-loaded collagen membrane].
abstract: OBJECTIVE
  To develop a new local delivery system, osteoclastic-inhibitor-loaded collagen membrane, and to evaluate its drug loading and drug release properties.
  
  
  METHODS
  Efforts were made to develop the drug-loaded membranes by combining two commercially available collagen barrier membranes (Bio-Gide and BME-10X) with zoledronic acid (ZA). The physicochemical and pharmacological properties of resulting materials were determined using SEM, EDS, FTIR, and HPLC.
  
  
  RESULTS
  After ZA loading, the micropores between the thin collagen fibers in the Bio-Gide disappeared, whereas crystalloid powders appeared on the surface of pore walls in BME-10X. Phosphorus was detected on both drug-loaded membranes. The Amides shifted. With the same drug solution, Bio-Gide presented larger amount of ZA loading and slower ZA release than BME-10X. ZA loading did not affect the 3D fiber network and the degradation of membranes.
  
  
  CONCLUSIONS
  Both collagen membranes load ZA successfully and delay drug release. But Bio-Gide shows higher loading values and slower release than BME-10X.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Meng
authors.forename: Xing
authors.initials: X
authors.lastname: Liang
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Hang
authors.initials: H
authors.lastname: Wang
authors.forename: Di
authors.initials: D
authors.lastname: Huang
authors.forename: Cheng-cheng
authors.initials: CC
authors.lastname: Zang
mesh_terms: D003094:Collagen; D003757:Dental Implantation; D004164:Diphosphonates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D008566:Membranes; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D004337:Drug Carriers; D007093:Imidazoles; D000077211:Zoledronic Acid; D003094:Collagen