title: [Synthesis of triterpenoid acylates - an effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses].
abstract: The synthesis of a new group of triterpenoid acylates on the basis of oleanolic, glycyrrhetic and ursolic acids and betulin is described. In studying the activity of the synthesized compounds in relation to reproduction of virus pathogens of respiratory infections 28-O-methoxycynnamoylbetulin shows high activity against influenza type A (H1N1) the selectivity index SI > 100. The high activity of 3,28-dinicotinoylbetulin against papilloma virus (strain HPV-11) was detected, the selectivity index SI was 35.
authors.forename: O B
authors.initials: OB
authors.lastname: Kazakova
authors.forename: N I
authors.initials: NI
authors.lastname: Medvedeva
authors.forename: I P
authors.initials: IP
authors.lastname: Baĭkova
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
authors.forename: T V
authors.initials: TV
authors.lastname: Lopatina
authors.forename: M S
authors.initials: MS
authors.lastname: Iunusov
authors.forename: L
authors.initials: L
authors.lastname: Zaprutko
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D004341:Drug Evaluation; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology*; D007251:Influenza, Human / Q000178:diet therapy; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000188:drug therapy; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D014315:Triterpenes