title: [Diagnosis and treatment of interstitial cystitis].
abstract: Interstitial Cystitis, first described in 1887 as an inflammatory disease of the bladder wall, is now regarded as a very common disease with an estimated number of unreported cases. Reasons for underdiagnosis is the widespread use of strict exclusion criteria. The disease can already be suspected by a careful medical history and physical examination in an early stage and then be treated with promising multimodal therapeutic approaches. In addition to a symptomatic oral therapy, local instillations with constituents of the protective glycosaminoglycan-layer are the most common therapeutic approach, because its defective integrity plays a key role in the pathogenesis of interstitial cystitis.
authors.affiliation: Klinik für Urologie, Kantonsspital St. Gallen. daniel.meyer@kssg.ch
authors.forename: D
authors.initials: D
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Gregorin
authors.forename: H-P
authors.initials: HP
authors.lastname: Schmid
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018856:Cystitis, Interstitial / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000628:therapy; D003558:Cystoscopy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D001743:Urinary Bladder / Q000473:pathology
chemical_list: D000700:Analgesics; D000925:Anticoagulants; D000929:Antidepressive Agents, Tricyclic; D018680:Cholinergic Antagonists; D010426:Pentosan Sulfuric Polyester