title: In vitro activity of nifuratel on vaginal bacteria: could it be a good candidate for the treatment of bacterial vaginosis?
abstract: Bacterial vaginosis is characterized by a shift of the physiological flora to a diverse spectrum of bacteria, where Gardnerella vaginalis and Atopobium vaginae are the most important markers. In this study, the antimicrobial activity of nifuratel against G. vaginalis, A. vaginae, and lactobacilli was compared with that of the two currently used antibiotics metronidazole and clindamycin. Results suggest that nifuratel has a better spectrum of activity, being highly active against G. vaginalis and A. vaginae without affecting lactobacilli.
authors.affiliation: Unilabs SA, Laboratoire Central de Suisse Romande, Ch. des Perrières 2, C.P. 100, CH-1296 Coppet, Switzerland. Giuseppe.togni@unilabs.com
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Togni
authors.forename: Valeria
authors.initials: V
authors.lastname: Battini
authors.forename: Anna
authors.initials: A
authors.lastname: Bulgheroni
authors.forename: Federico
authors.initials: F
authors.lastname: Mailland
authors.forename: Maurizio
authors.initials: M
authors.lastname: Caserini
authors.forename: Werner
authors.initials: W
authors.lastname: Mendling
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002981:Clindamycin / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009545:Nifuratel / Q000494:pharmacology* / Q000627:therapeutic use*; D014621:Vagina / Q000382:microbiology*; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002981:Clindamycin; D009545:Nifuratel