title: The effect of local breast radiotherapy on circulating CD34(+) cells.
abstract: The number of circulating CD34(+) (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.
authors.affiliation: Ontario Cancer Institute, Toronto, Canada.
authors.forename: Nehad M
authors.initials: NM
authors.lastname: Alajez
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Debashis
authors.initials: D
authors.lastname: Biswas
authors.forename: Amy
authors.initials: A
authors.lastname: Teh
authors.forename: Robert
authors.initials: R
authors.lastname: Sutherland
authors.forename: Melania
authors.initials: M
authors.lastname: Pintilie
authors.forename: Mark
authors.initials: M
authors.lastname: Minden
authors.forename: Hans
authors.initials: H
authors.lastname: Messner
authors.forename: Anthony
authors.initials: A
authors.lastname: Fyles
authors.forename: Mary
authors.initials: M
authors.lastname: Gospodarowicz
authors.forename: Armand
authors.initials: A
authors.lastname: Keating
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D006801:Humans; D008875:Middle Aged
chemical_list: D018952:Antigens, CD34