title: One NOTCH Further: Jagged 1 in Bone Metastasis.
abstract: The outgrowth of metastatic cells to bone depends on the interaction between multiple intrinsic and host factors. In this issue of Cancer Cell, Sethi and colleagues report Notch signaling in bone cells as responsible for promoting this outgrowth and provide evidence for a beneficial treatment effect of NOTCH inhibitors.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Jianning
authors.initials: J
authors.lastname: Tao
authors.forename: Ayelet
authors.initials: A
authors.lastname: Erez
authors.forename: Brendan
authors.initials: B
authors.lastname: Lee