title: Management of retinal vasoproliferative tumor associated with ROP by plaque brachytherapy.
abstract: The authors report a secondary exudative vasoproliferative tumor of the retina associated with retinopathy of prematurity, managed by plaque radiotherapy. A 15-year-old girl with a history of mild, stable retinopathy of prematurity in both eyes noted progressively reduced visual acuity to hand motions in the left eye. Examination disclosed a vasoproliferative tumor of 10-mm base and 3.5-mm thickness with near total (macula-off) exudative retinal detachment. She was treated with iodine-125 plaque radiotherapy, giving apex dose of 40 Gy over 4 days. The tumor regressed to 1.9 mm and retinal detachment resolved 8 months following therapy. Epiretinal membrane with significant macular pucker and edema later developed and was managed with pars plana vitrectomy and membrane peeling. Visual acuity was counting fingers due to photoreceptor loss. Retinopathy of prematurity is a rare cause of vasoproliferative tumor. Iodine-125 plaque radiotherapy can lead to tumor regression and reattachment of the retina in such cases.
authors.affiliation: Ocular Oncology Service, Suite 1440, Wills Eye Institute, 840 Walnut Street, Philadelphia, PA 19107, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Kitei
authors.forename: Emil Anthony T
authors.initials: EA
authors.lastname: Say
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Carl D
authors.initials: CD
authors.lastname: Regillo
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D000293:Adolescent; D001918:Brachytherapy; D005260:Female; D006391:Hemangioma / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D012163:Retinal Detachment / Q000473:pathology / Q000532:radiotherapy*; D019572:Retinal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D012171:Retinal Vessels / Q000473:pathology / Q000528:radiation effects*; D012178:Retinopathy of Prematurity / Q000473:pathology*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
chemical_list: D007457:Iodine Radioisotopes