title: Isolated splenic metastasis of ovarian cancer 20 years after operation: a case report and literature review.
abstract: Splenic metastasis reflecting multiple metastases of cancer is often observed in the terminal stage, although solitary splenic metastasis is extremely rare. In addition, late recurrence even after 20 years of operation is very unusual. We report the case of a 52-year-old woman who was admitted to our department with a splenic tumor. She had a past history of total abdominal hysterectomy with bilateral sapingo-oophorectomy for ovarian cancer 20 years ago. Abdominal CT scan revealed a huge mass of 12 x 8 x 5.5 cm between the spleen and the left kidney. Splenectomy was performed with a diagnosis of splenic tumor. Microscopically, the tumor was a poorly differentiated adenocarcinoma including components of poorly differentiated ovarian cancer, and was diagnosed as an ovarian cancer metastasis. The patient showed no evidence of recurrence until 5 years postoperatively. Splenic metastasis is considered a terminal stage of cancer. However, when the lesion is solitary, surgical treatment is recommended.
authors.affiliation: Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Kita, Kagawa, Japan. izuishi@kms.ac.jp
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Izuishi
authors.forename: Takanori
authors.initials: T
authors.lastname: Sano
authors.forename: Hisashi
authors.initials: H
authors.lastname: Usuki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Okano
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Masaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kushida
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000556:secondary* / Q000601:surgery; D000328:Adult; D018293:Cystadenoma, Serous / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery*; D010052:Ovariectomy; D049268:Positron-Emission Tomography / Q000379:methods; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D014057:Tomography, X-Ray Computed