title: Selective internal radiation therapy: 90Y (yttrium) labeled microspheres for liver malignancies (primary and metastatic).
abstract: Selective Internal Radiation Therapy is a relatively new technique that irradiates malignant liver lesions using microscopic beads. It provides micro-embolization coupled with high-dose interstitial radiotherapy. Besides colorectal cancers, this therapy has shown benefit in patients with a variety of other tumors including carcinoid tumors, lung, breast, sarcoma, colon, hepatocellular and ocular melanoma. Its clinical benefit can be as much as 85%, survival can be doubled and patients with extensive colorectal metastases not amenable to resection or ablation can be offered a 32% chance of surviving for 18 months. Ongoing and future studies will refine our understanding of optimizing patient eligibility, dosage, frequency as well as novel applications.
authors.affiliation: Department of Radiology, Manipal Hospital, Old Airport Road, Bangalore-560 017, India. uthappas@hotmail.com
authors.forename: M C
authors.initials: MC
authors.lastname: Uthappa
authors.forename: R
authors.initials: R
authors.lastname: Ravikumar
authors.forename: A
authors.initials: A
authors.lastname: Gupta
mesh_terms: D001918:Brachytherapy; D002986:Clinical Trials as Topic; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D008863:Microspheres; D011379:Prognosis; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D015021:Yttrium Radioisotopes