title: Limb salvage with major nerve injury: current management and future directions.
abstract: Major peripheral nerve injuries are often associated with devastating functional deficits. Current management techniques fail to achieve adequate functional neural regeneration, and the development of adjunct therapies is necessary to improve outcomes. Recent efforts at enhancing the regeneration rate of peripheral nerves and developing axonal guidance channels or conduits have had limited success. The neuromuscular junction serves as the interface between the peripheral nerves and muscle. This critical area undergoes significant changes following peripheral nerve injury and induces end-organ atrophy after denervation, which limits the chance of true functional regeneration. Stabilization of the neuromuscular junction may be an important adjunct in peripheral nerve repair and should be explored as a method of managing major nerve injuries.
authors.affiliation: Limb salvage with major nerve injury: current management and future directions.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Kang
authors.forename: David P
authors.initials: DP
authors.lastname: Zamorano
authors.forename: Ranjan
authors.initials: R
authors.lastname: Gupta
mesh_terms: D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006225:Hand / Q000294:innervation; D006230:Hand Injuries / Q000150:complications / Q000601:surgery*; D006801:Humans; D007866:Leg / Q000294:innervation; D007869:Leg Injuries / Q000150:complications / Q000601:surgery*; D023821:Limb Salvage / Q000379:methods*; D009416:Nerve Regeneration; D019635:Neurosurgical Procedures / Q000379:methods*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*