title: [Expression of GLUT1 protein and its relationship with uptake of FDG in non-small cell lung cancer tissues].
abstract: BACKGROUND
  To investigate the expression of facilitative glucose transporter 1 (GLUT1) and its relationship with uptake of 18fluoro-2-deoxyglucose (FDG) in non small cell lung cancer (NSCLC).
  
  
  METHODS
  Twenty-four patients with NSCLC were evaluated with 18FDG-PET examination before operation. The expression of GLUT1 was detected immunohistochemically in lung cancer and normal lung tissues, and the intensity of GLUT1 in lung cancer was assessed by computer image analysis. Correlation analysis was carried out between expression level of GLUT1 and value of SUV obtained from preoperative FDG-PET.
  
  
  RESULTS
  Expression of GLUT1 protein was positive in 24 cases of NSCLC samples, but negative in corresponding normal tissues. A highly significant linear correlation was found between GLUT1 expression and SUV value (r= 0.86, P < 0.05).
  
  
  CONCLUSIONS
  GLUT1 expression is quite general in NSCLC tissues, and it may play an important role in the glucose uptake of NSCLC cells.
authors.affiliation: Department of Thoracic Surgery, General Hospital of Beijing Unit,PLA, Beijing 100700, P.R.China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Yu'e
authors.initials: Y
authors.lastname: Sun
authors.forename: Tao
authors.initials: T
authors.lastname: Wang