title: Stretch syncope: reflex vasodepressor faints easily mistaken for epilepsy.
abstract: The pathophysiology of stretch syncope is demonstrated through the clinical, electrophysiological, and hemodynamic findings in three patients. Fifty-seven attacks were captured by video/EEG monitoring. Simultaneous EEG, transcranial (middle cerebral artery) doppler, and continuous arterial pressure measurements were obtained for at least one typical attack of each patient. They all experienced a compulsion to precipitate their attacks. Episodes started with a stereotyped phase of stretching associated with neck torsion and breath holding, followed by a variable degree of loss of consciousness and asymmetric, recurrent facial and upper limb jerks in the more prolonged episodes. Significant sinus tachycardia coincided with the phase of stretching and was followed within 9-16 seconds by rhythmic generalized slow wave abnormalities on the EEG in attacks with impairment of consciousness. Transcranial doppler studies showed a dramatic drop in cerebral perfusion in the middle cerebral arteries during the episodes. The combination of the stereotyped semiology of the attacks, the pseudofocal myoclonic jerking, and the rhythmic generalized slow wave EEG abnormalities with the tachycardia make differential diagnosis from epilepsy challenging.
authors.affiliation: Department of Clinical Neurophysiology, Royal Hallamshire Hospital, Sheffield, UK. p.sarrigiannis@sheffield.ac.uk
authors.forename: Ptolemaios Georgios
authors.initials: PG
authors.lastname: Sarrigiannis
authors.forename: Marc
authors.initials: M
authors.lastname: Randall
authors.forename: Rosalind H
authors.initials: RH
authors.lastname: Kandler
authors.forename: Richard A
authors.initials: RA
authors.lastname: Grunewald
authors.forename: Kirsty
authors.initials: K
authors.lastname: Harkness
authors.forename: Markus
authors.initials: M
authors.lastname: Reuber
mesh_terms: D000328:Adult; D019781:Corneal Topography; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology; D012018:Reflex / Q000502:physiology*; D019462:Syncope, Vasovagal / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013686:Telemetry / Q000379:methods; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods; D055815:Young Adult