title: Transient Transgenic Approaches for Investigating the Role of GM-CSF in Pulmonary Inflammation and Immune Diseases.
abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF), a 23-kDa polypeptide, was originally identified as a hematopoietic growth factor, but has recently been found to be a multifunctional cytokine with many proinflammatory activities (1,2). GM-CSF can be produced by, and act upon, a broad range of cell types, including both immature and mature granulocyte and monocyte lineage cells, dendritic cells, and tissue structural cells. Abundant in vitro observations have suggested that GM-CSF is able to induce both differentiation and activation of these cells (1).
authors.affiliation: Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Z
authors.initials: Z
authors.lastname: Xing
authors.forename: M R
authors.initials: MR
authors.lastname: Stämpfli
authors.forename: J
authors.initials: J
authors.lastname: Gauldie