title: Design, synthesis and structure-activity relationship of novel coumarin derivatives.
abstract: BACKGROUND
  The lead coumarin derivative (E)-methyl 3-methoxy-2-[2-(4-methylcoumarin-7-yloxymethyl)phenyl]acrylate was discovered by using an intermediate derivatisation method. To discover new coumarin derivatives with improved activity, a series of substituted coumarins were synthesised and bioassayed.
  
  
  RESULTS
  The compounds were identified by ¹H NMR, IR, MS and elemental analysis. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activity against cucumber downy mildew at 25 mg L⁻¹. The relationship between structure and fungicidal activity is reported.
  
  
  CONCLUSIONS
  The present work demonstrates that coumarin derivatives containing methoxyacrylate moieties can be used as possible lead compounds for developing novel fungicides.
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Research Institute of Chemical Industry, Shenyang, China.
authors.forename: Ai-Ying
authors.initials: AY
authors.lastname: Guan
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Liu
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhi-Nian
authors.initials: ZN
authors.lastname: Li
authors.forename: Zheng-Ming
authors.initials: ZM
authors.lastname: Li
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects*; D001681:Biological Assay; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009868:Oomycetes / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000179:Acrylates; D000935:Antifungal Agents; D003374:Coumarins; C575069:methyl 2-(2-(3-n-butyl-4-methylcoumarin-7-yloxymethyl)phenyl)-3-methoxyacrylate