title: Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population.
abstract: Human brain arteriovenous malformation (BAVM) tissue contains increased levels of vascular endothelial growth factor A (VEGFA). We carried out a case-control study to determine whether polymorphisms in the VEGFA gene are associated with sporadic BAVM. Nine selected VEGFA single-nucleotide polymorphisms (SNP) were genotyped in 319 patients with BAVM and 333 controls from a Chinese population using the MassARRAY genotyping system. We found four single variants in the VEGFA gene (rs1547651, rs2010963, rs833069 and rs3025010), with one haplotype, ACT, possibly associated with the risk of developing BAVM.
authors.affiliation: State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Chen
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Gu
authors.forename: Wenting
authors.initials: W
authors.lastname: Wu
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.forename: Peiliang
authors.initials: P
authors.lastname: Li
authors.forename: Weiwei
authors.initials: W
authors.lastname: Fan
authors.forename: Daru
authors.initials: D
authors.lastname: Lu
authors.forename: Fan
authors.initials: F
authors.lastname: Zhao
authors.forename: Nidan
authors.initials: N
authors.lastname: Qiao
authors.forename: Huijia
authors.initials: H
authors.lastname: Qiu
authors.forename: Chaowei
authors.initials: C
authors.lastname: Fu
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A