title: Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation.
abstract: The aim of the clinical study was to evaluate the effect of Testofen, a standardized Trigonella foenum-graecum (Fenugreek) extract and mineral formulation, on male libido (sexual drive, urge or desire) in a double blind randomized placebo controlled study. The study recruited 60 healthy males aged between 25 and 52, without erectile dysfunction and randomized to an oral dose (two tablets per day) of the active treatment (600 mg Testofen per day) or placebo for 6 weeks. The primary outcome measure was the DISF-SR (male) self-administered QOL total score and the four domain scores. The secondary outcome was specific quality of life parameters. Testofen had an overall positive effect on physiological aspects of libido. In particular, there was a significant increase in the subdomains of sexual arousal and orgasm. Testofen had a positive effect on QOL in self-reported satisfaction with muscle strength, energy and well-being but did not have an effect on mood or sleep. Serum prolactin and testosterone levels remained within the reference range. It was concluded that Testofen demonstrated a significant positive effect on physiological aspects of libido and may assist to maintain normal healthy testosterone levels.
authors.affiliation: Applied Science and Nutrition Pty Ltd, Clinical Trials, Brisbane, Australia. beth@asnresearch.com.au.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Steels
authors.forename: Amanda
authors.initials: A
authors.lastname: Rao
authors.forename: Luis
authors.initials: L
authors.lastname: Vitetta
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D007989:Libido / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010936:Plant Extracts / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D011736:Pyridoxine / Q000494:pharmacology; D011788:Quality of Life; D013739:Testosterone / Q000097:blood; D029910:Trigonella / Q000737:chemistry*; D015032:Zinc / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D013739:Testosterone; D011388:Prolactin; D008274:Magnesium; D015032:Zinc; D011736:Pyridoxine