title: Microwave-induced facile synthesis of water-soluble fluorogenic alginic acid derivatives.
abstract: A facile microwave-induced method was developed for synthesizing water-soluble fluorescent derivatives of alginic acid (ALG) with four different diamines, hydrazine (HY), ethylenediamine (EDA), 1,6-hexanediamine (HDA), and 1,4-cyclohexanediamine (CHDA), followed by a cross-linking reaction with a natural cross linker genipin. The ethylenediamine derivative of alginic acid (ALG-EDA) exhibited good fluorescent activity, which upon cross linking was enhanced threefold. The other amide derivatives, for example, ALG-HY, ALG-HDA, and ALG-CHDA, were not fluorescent, but their respective crosslinked products exhibited excellent fluorescent activity. The fluorescence intensity had an inverse correlation with the number of carbon atoms present in the amine, which in turn was a function of degree of substitution (DS). These fluorescent polysaccharide derivatives are of potential utility in the domain of sensor applications.
authors.affiliation: Marine Biotechnology and Ecology Discipline, Central Salt & Marine Chemicals Research Institute, Council of Scientific & Industrial Research, G. B. Marg, Bhavnagar 364 021, Gujarat, India.
authors.forename: Mahesh U
authors.initials: MU
authors.lastname: Chhatbar
authors.forename: Ramavatar
authors.initials: R
authors.lastname: Meena
authors.forename: Kamalesh
authors.initials: K
authors.lastname: Prasad
authors.forename: Dharmesh R
authors.initials: DR
authors.lastname: Chejara
authors.forename: A K
authors.initials: AK
authors.lastname: Siddhanta
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002240:Carbohydrate Sequence; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D057889:Iridoid Glycosides / Q000737:chemistry; D039823:Iridoids; D008872:Microwaves; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D057889:Iridoid Glycosides; D039823:Iridoids; D020723:Glucuronic Acid; C007834:genipin