title: Rapid grafting of azido-labeled oligo(ethylene glycol)s onto an alkynyl-terminated monolayer on nonoxidized silicon via microwave-assisted "click" reaction.
abstract: Microwave (MW) irradiation was used for the grafting of azido-labeled oligo(ethylene oxide) (OEG) on alkynyl-terminated nonoxidized silicon substrates via copper-catalyzed "click" reaction. The "clickable" monolayers were prepared by photografting of an α,ω-alkynene, where the alkynyl terminus was protected by a trimethylgermanyl (TMG) group, onto hydrogen-terminated Si(111) surfaces. X-ray photoelectron spectroscopy (XPS) was primarily employed to characterize the monolayers, and the data obtained were utilized to calculate the surface density of the TMG-alkynyl-functionalized substrate. MW-assisted one-pot deprotection/click reaction was optimized on the surfaces using azido-tagged OEG derivatives. Using MW instead of conventional heating led to a substantial improvement in the rate of the reaction while suppressing the oxidation of the silicon interface and OEG degradation. The antifouling property of the resulting substrates was evaluated using fibrinogen as a model protein. Results show that the OEG-modification reduced the protein adsorption by >90%.
authors.affiliation: Department of Chemistry, University of Houston, Houston, Texas 77204, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Cai
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D057219:Biofouling / Q000517:prevention & control; D057930:Click Chemistry; D019855:Ethylene Glycol / Q000737:chemistry*; D005340:Fibrinogen / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D012825:Silicon / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D005340:Fibrinogen; D019855:Ethylene Glycol; D012825:Silicon