title: Computational approaches to studying thrombus development.
abstract: In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of processes involved in hemostasis/thrombosis are being integrated to simulate the development of the thrombus simultaneously in time and space. Further development of computational approaches can provide quantitative insights leading to predictions that are not obvious from qualitative biological models.
authors.affiliation: Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Xu
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Kamocka
authors.forename: Mark
authors.initials: M
authors.lastname: Alber
authors.forename: Elliot D
authors.initials: ED
authors.lastname: Rosen
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D019295:Computational Biology; D003198:Computer Simulation; D005337:Fibrin / Q000737:chemistry / Q000378:metabolism; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008955:Models, Cardiovascular; D015539:Platelet Activation; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013927:Thrombosis / Q000097:blood*
chemical_list: D005337:Fibrin; D005340:Fibrinogen