title: Trends in incidence of borderline ovarian tumors in Denmark 1978-2006.
abstract: OBJECTIVE
  To examine period-, age- and histology-specific trends in the incidence rate of borderline ovarian tumors in Denmark in 1978-2006.
  
  
  METHODS
  Register-based cohort study.
  
  
  METHODS
  Denmark 1978-2006.
  
  
  METHODS
  5079 women diagnosed with a borderline ovarian tumor in at least one of two nationwide registries (4312 epithelial tumors and 767 non-epithelial/unspecified tumors).
  
  
  METHODS
  Estimation of overall incidence rates and period-, age- and histology-specific incidence rates. Age-adjustment was done using the World Standard POPULATION. To evaluate incidence trends over time, we estimated average annual percentage change and 95% confidence intervals (CI) using log-linear Poisson models.
  
  
  METHODS
  Age-standardized and age-specific incidence rates and average annual percentage change.
  
  
  RESULTS
  The incidence of epithelial borderline ovarian tumors increased from 2.6 to 5.5 per 100,000 women-years between 1978 and 2006, with an average annual percentage change of 2.6% (95% CI: 2.2-3.0). The median age at diagnosis was 52 years. Women 40 years or older had a higher average annual percentage change than women younger than 40 years. Most tumors were mucinous (49.9%) and serous tumors (44.4%). Women with mucinous tumors were younger at diagnosis (50 years) compared with women with serous tumors (53 years). Women with serous tumors had a higher average annual percentage incidence change than women with mucinous tumors.
  
  
  CONCLUSIONS
  The incidence rate of borderline ovarian tumors increased significantly in Denmark in 1978-2006. In line with results for ovarian cancer, Denmark had a higher incidence rate of borderline ovarian tumors compared with the other Nordic countries in 1978-2006.
authors.affiliation: Department of Viruses, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark.
authors.forename: Charlotte Gerd
authors.initials: CG
authors.lastname: Hannibal
authors.forename: Lene Drasbek
authors.initials: LD
authors.lastname: Huusom
authors.forename: Anette
authors.initials: A
authors.lastname: Kjaerbye-Thygesen
authors.forename: Ann
authors.initials: A
authors.lastname: Tabor
authors.forename: Susanne K
authors.initials: SK
authors.lastname: Kjaer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077216:Carcinoma, Ovarian Epithelial; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology*; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D016012:Poisson Distribution; D055815:Young Adult