title: Chemical construction of immunotoxins.
abstract: Immunotoxins (ITs) are chimeric proteins consisting of an antibody linked to a toxin. The antibody confers specificity (ability to recognize and react with the target), whereas the toxin confers cytotoxicity (ability to kill the target) (1-3). ITs have been used in both mice and humans to eliminate tumor cells, autoimmune cells, and virus-infected cells (4-6.
authors.affiliation: Department of Microbiology and Cancer Immunobiology Center, The University of Texas South Western Medical Center at Dallas, TX.
authors.forename: V
authors.initials: V
authors.lastname: Ghetie
authors.forename: E S
authors.initials: ES
authors.lastname: Vitetta