title: Engineering, characterization and directional self-assembly of anisotropically modified nanocolloids.
abstract: Along with traditional attributes such as the size, shape, and chemical structure of polymeric micro-objects, control over material distribution, or selective compartmentalization, appears to be increasingly important for maximizing the functionality and efficacy of biomaterials. The fabrication of tri- and tetracompartmental colloids made from biodegradable poly(lactide-co-glycolide) polymers via electrohydrodynamic co-jetting is demonstrated. The presence of three compartments is confirmed via flow cytometry. Additional chemical functionality is introduced via the incorporation of acetylene-functionalized polymers into individual compartments of the particles. Direct visualization of the spatioselective distribution of acetylene groups is demonstrated by confocal Raman microscopy as well as by reaction of the acetylene groups with azide-biotin via 'click chemistry'. Biotin-streptavidin binding is then utilized for the controlled assembly and orientation of bicompartmental particles onto functionalized, micropatterned substrates prepared via chemical vapor deposition polymerization.
authors.affiliation: Macromolecular Science and Engineering, University of Michigan, Ann Arbor 48109, USA.
authors.forename: Srijanani
authors.initials: S
authors.lastname: Bhaskar
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Gibson
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Himabindu
authors.initials: H
authors.lastname: Nandivada
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Deng
authors.forename: Nicolas H
authors.initials: NH
authors.lastname: Voelcker
authors.forename: Joerg
authors.initials: J
authors.lastname: Lahann
mesh_terms: D016880:Anisotropy; D001672:Biocompatible Materials / Q000737:chemistry; D003102:Colloids / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003102:Colloids; D011108:Polymers