title: Blockage of longitudinal flow in Meniere's disease: A human temporal bone study.
abstract: CONCLUSIONS
  Blockage of the endolymphatic duct is a significant finding in Meniere's disease. The position of the utriculo-endolymphatic valve (UEV) and blockage of the ductus reuniens in the temporal bones were not found to be directly indicative of Meniere's disease.
  
  
  OBJECTIVE
  Comparison of blockage of the longitudinal flow of endolymph between ears affected by Meniere's disease and normal ears.
  
  
  METHODS
  We examined 21 temporal bones from 13 subjects who had Meniere's disease and 21 normal temporal bones from 12 controls.
  
  
  RESULTS
  The endolymphatic duct was blocked in five (23%) ears affected by Meniere's disease (p = 0.016). The utricular duct was blocked in 16 (76%) ears affected by Meniere's disease and 11 (52%) normal ears (p = 0.112). The saccular duct was blocked in 6 (28%) of ears affected by Meniere's disease and 16 (76%) normal ears (p = 0.001). The ductus reuniens was blocked in 10 (47%) ears affected by Meniere's disease and 10 (47%) normal ears (p = 1.000).
authors.affiliation: Department of Otolaryngology, Tokyo Medical University, Japan.
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Shimizu
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yoda
authors.forename: Mamoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
mesh_terms: D000368:Aged; D004710:Endolymph / Q000502:physiology; D004711:Endolymphatic Duct / Q000473:pathology*; D006801:Humans; D008575:Meniere Disease / Q000473:pathology*; D008875:Middle Aged; D013701:Temporal Bone / Q000473:pathology*