title: Production and use of chimeric mice.
abstract: The gene-targeting technology allows complete and selective inactivation of a specific gene to study the consequence of total absence of the gene product. The availability of such null-mutant mice enables investigators to identify the biological function of the gene product in physiological or pathophysiological conditions. This technology, popularly known as "gene knockout," can also induce more subtle mutations at the targeted site of the genome.
authors.affiliation: Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN.
authors.forename: J
authors.initials: J
authors.lastname: Takaya
authors.forename: T
authors.initials: T
authors.lastname: Matsusaka
authors.forename: I
authors.initials: I
authors.lastname: Ichikawa