title: Immunization trials with an avian chlamydial MOMP gene recombinant adenovirus.
abstract: Chicks were inoculated with a live vector vaccine of avian chlamydial MOMP gene recombinant adenovirus to evaluate efficacy, safety and viability of the vaccine. Five batches of the recombinant adenovirus vaccines, which were prepared using the 22nd generation avian chlamydial MOMP gene recombinant adenovirus cultured in HEK293 cells, were used to vaccinate 7 days-old chicks negative for chlamydial antibody. The recombinant adenovirus vaccine was shown to be both safe and effective in inducing specific immunity in vaccinated chicks.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China. cqqiu@126.com
authors.forename: Changqing
authors.initials: C
authors.lastname: Qiu
authors.forename: Jizhang
authors.initials: J
authors.lastname: Zhou
authors.forename: Xiao-an
authors.initials: XA
authors.lastname: Cao
authors.forename: Guozhen
authors.initials: G
authors.lastname: Lin
authors.forename: Fuying
authors.initials: F
authors.lastname: Zheng
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Gong
mesh_terms: D000818:Animals; D000259:Aviadenovirus / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D002645:Chickens; D002689:Chlamydia / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology / Q000517:prevention & control; D057809:HEK293 Cells; D006801:Humans; D007114:Immunization / Q000379:methods
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines