title: Shorter synthesis of trifunctionalized cryptophane-A derivatives.
abstract: Efficient syntheses of trisubstituted cryptophane-A derivatives that are versatile host molecules for many applications are reported. Trihydroxy cryptophane was synthesized in six or seven steps with yields as high as 9.5%. By a different route, trihydroxy cryptophane modified with three propargyl, allyl, or benzyl protecting groups was synthesized with yields of 4.1-5.8% in just six steps. Hyperpolarized (129)Xe NMR chemical shifts of 57-65 ppm were measured for these trisubstituted cryptophanes.
authors.affiliation: Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Olena
authors.initials: O
authors.lastname: Taratula
authors.forename: P Aru
authors.initials: PA
authors.lastname: Hill
authors.forename: Yubin
authors.initials: Y
authors.lastname: Bai
authors.forename: Najat S
authors.initials: NS
authors.lastname: Khan
authors.forename: Ivan J
authors.initials: IJ
authors.lastname: Dmochowski
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D014978:Xenon / Q000737:chemistry*
chemical_list: D011083:Polycyclic Compounds; C545484:cryptophane A; D014978:Xenon