title: Use of palivizumab and infection control measures to control an outbreak of respiratory syncytial virus in a neonatal intensive care unit confirmed by real-time polymerase chain reaction.
abstract: Respiratory syncytial virus (RSV) is a potentially life-threatening infection in premature infants. We report an outbreak involving four infants in the neonatal intensive care unit (NICU) of our hospital that occurred in February 2010. RSV A infection was confirmed by real-time polymerase chain reaction. Palivizumab was administered to all infants in the NICU. There were no additional symptomatic cases and repeat RSV surveillance confirmed that there was no further cross-transmission within the unit. The outbreak highlighted the infection control challenge of very high bed occupancy in the unit and the usefulness of molecular methods in facilitating detection and management.
authors.affiliation: Department of Clinical Microbiology, University College Hospital, Galway, Ireland. karinaoconnell@gmail.com
authors.forename: K
authors.initials: K
authors.lastname: O'Connell
authors.forename: T W
authors.initials: TW
authors.lastname: Boo
authors.forename: D
authors.initials: D
authors.lastname: Keady
authors.forename: U
authors.initials: U
authors.lastname: Niriain
authors.forename: D
authors.initials: D
authors.lastname: O'Donovan
authors.forename: M
authors.initials: M
authors.lastname: Commane
authors.forename: C
authors.initials: C
authors.lastname: Faherty
authors.forename: M
authors.initials: M
authors.lastname: Cormican
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D000998:Antiviral Agents / Q000008:administration & dosage*; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017053:Infection Control / Q000379:methods; D015931:Intensive Care, Neonatal; D000069455:Palivizumab; D016133:Polymerase Chain Reaction; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D018113:Respiratory Syncytial Virus, Human / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000998:Antiviral Agents; D004279:DNA, Viral; D000069455:Palivizumab