title: Exercise treadmill testing in patients with claudication, with and without diabetes.
abstract: OBJECTIVE
  To compare symptoms and walking capacities of patients with and without diabetes reporting vascular-type claudication.
  
  
  METHODS
  We recorded self-reported maximal walking distance, maximal walking distance on treadmill test (3.2 km h(-1) , 10% slope), exercise transcutaneous oxygen pressure DROP index [limb transcutaneous oxygen pressure (TcpO2) changes from rest minus chest TcpO2 changes from rest] and symptoms on treadmill in 230 patients with diabetes and 982 patients without diabetes. Exercise-induced proximal and distal symptoms were analysed in the perspective of underlying proximal and distal ischaemia (DROP value < negative 15 mmHg).
  
  
  RESULTS
  Self-reported maximal walking distance did not differ between groups, whereas maximal walking distance on treadmill test was lower in patients with diabetes vs. patients without diabetes (261 ± 257 and 339 ± 326 m, respectively; P < 0.05 when adjusted for potential confounders). In patients with ischaemia, the number of ischaemic areas (proximal and/or distal on right and/or left) was comparable between the two groups. Patients with diabetes had more distal ischaemia than patients without diabetes (38 vs. 29%, respectively; P < 0.01), whereas proximal ischaemia was similar between groups. The prevalence of lower-limb exercise-related symptoms without ischaemia was comparable between groups. There were more symptoms other than lower-limb pain in patients with diabetes than patients without diabetes (29.6 vs. 18.3%, respectively; P < 0.01).
  
  
  CONCLUSIONS
  Patients with diabetes show more severe limitation on the treadmill and more non-limb symptoms than patients without diabetes, although self-reported walking capacity is comparable between the two groups. Using TcpO2, we confirm that patients with diabetes reporting claudication show more distal ischaemia than patients without diabetes, with no difference at the buttock level. Treadmill testing is of interest in patients with peripheral artery disease and diabetes.
authors.affiliation: Department of Physiology and Vascular Investigations, University Hospital UMR INSERM 771 - CNRS 6214, France.
authors.forename: G
authors.initials: G
authors.lastname: Mahé
authors.forename: N
authors.initials: N
authors.lastname: Ouedraogo
authors.forename: G
authors.initials: G
authors.lastname: Leftheriotis
authors.forename: B
authors.initials: B
authors.lastname: Vielle
authors.forename: J
authors.initials: J
authors.lastname: Picquet
authors.forename: P
authors.initials: P
authors.lastname: Abraham
mesh_terms: D000704:Analysis of Variance; D001785:Blood Gas Monitoring, Transcutaneous; D002081:Buttocks / Q000098:blood supply; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D005080:Exercise Test / Q000379:methods*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007511:Ischemia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D016138:Walking