title: Sporadic primary malignant intracerebral nerve sheath tumors: case report and literature review.
abstract: We report the case of a seventy-five year old woman with a sporadic primary malignant intracerebral nerve sheath tumor (MINST). These tumors fall within the spectrum of malignant peripheral nerve sheath tumors (MPNST) but confirming the diagnosis of a MINST can be difficult due to its rarity and unusual intraparenchymal location. Radiographically, MINST's mimic malignant glioma and should be considered in the differential diagnosis of enhancing cerebral lesions. In this report, we present a comprehensive panel of histological, immunohistochemical, ultrastructural, and genetic considerations that may be used to diagnosis MINST based on their similarities to MPNSTs and brain parenchyma location.
authors.affiliation: Department of Surgery (Neurosurgery), Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. zbarnard@gmail.com
authors.forename: Zachary Rollins
authors.initials: ZR
authors.lastname: Barnard
authors.forename: Pankaj Kumar
authors.initials: PK
authors.lastname: Agarwalla
authors.forename: Deva Sanjeeva
authors.initials: DS
authors.lastname: Jeyaretna
authors.forename: Christopher James
authors.initials: CJ
authors.lastname: Farrell
authors.forename: Elizabeth Robins
authors.initials: ER
authors.lastname: Gerstner
authors.forename: Di
authors.initials: D
authors.lastname: Tian
authors.forename: William Thomas
authors.initials: WT
authors.lastname: Curry
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D046529:Microscopy, Electron, Transmission; D018317:Nerve Sheath Neoplasms / Q000473:pathology*