title: Unilateral eyelid angioedema with congestion of the right bulbar conjunctiva due to loxoprofen sodium.
abstract: Angioedema is a variant of urticaria that causes deep dermal and subcutaneous swelling. It frequently is a unilateral reaction and usually lasts for several hours but may persist for several days. We report 2 cases of angioedema that involved the right upper and lower eyelids and was associated with congestion of the right bulbar conjunctiva; the symptoms started approximately 1 to 2 hours after taking loxoprofen sodium. All of the symptoms subsided after oral corticosteroid therapy. In both cases, an oral challenge test with 60 mg of loxoprofen sodium (contained in a tablet) caused swelling of the right upper eyelid within several hours, followed by swelling of the right bulbar conjunctiva. We believe the drug reaction in both patients is angioedema.
authors.affiliation: Department of Dermatology, Osaka City University Graduate School of Medicine, Japan. dtsuruta@med.osaka-cu.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsuruta
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oshimo
authors.forename: Junko
authors.initials: J
authors.lastname: Sowa
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Ishii
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D000799:Angioedema / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003229:Conjunctival Diseases / Q000139:chemically induced*; D005141:Eyelid Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D010666:Phenylpropionates / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; C040656:loxoprofen