title: Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia.
abstract: The ratio of magnetoencephalogram-recorded brain responses occurring 50ms after paired clicks (S2-evoked M50/S1-evoked M50) serves as a measure of sensory gating. An abnormally large ratio is commonly found in schizophrenia. Whether this abnormality indicates impaired gating is debated. Using event-related oscillations the present study sought to elucidate processes contributing to the phenomenon of altered M50 gating ratio. Schizophrenia inpatients (n=50) showed the expected large M50 gating ratio relative to 48 healthy controls, which correlated with less induced frontally generated activity in the 10-15Hz frequency band starting 200ms before the onset of S2. Patients also produced smaller alpha (8-12Hz) and gamma (60-80Hz) responses to S1. Results suggest that the deviant gating ratio in schizophrenia is a consequence of a complex alteration in the processing of incoming information that cannot be attributed to impaired gating alone.
authors.affiliation: Department of Psychology, University of Konstanz, Germany. Tzvetan.Popov@uni-konstanz.de
authors.forename: Tzvetan
authors.initials: T
authors.lastname: Popov
authors.forename: Todor
authors.initials: T
authors.lastname: Jordanov
authors.forename: Nathan
authors.initials: N
authors.lastname: Weisz
authors.forename: Thomas
authors.initials: T
authors.lastname: Elbert
authors.forename: Brigitte
authors.initials: B
authors.lastname: Rockstroh
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Miller
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D012559:Schizophrenia / Q000503:physiopathology*; D055139:Sensory Gating / Q000502:physiology*