title: Periocular allergic contact dermatitis following topical Mitomycin C eye drop application.
abstract: A 63-year-old women had an extensive limbal papilliform tumoural lesion of her left eye. Mitomycin C (MMC) was applied to the area at a dose of 0.2 mg/ml after total surgical excision of the lesion. The lesion was diagnosed as invasive squamous cell carcinoma on histopathology and topical 0.02% MMC was prescribed four times daily to the left eye. A severe per ocular contact dermatitis of the left eye developed two days after starting MMC. The patch test result was positive. The per ocular dermatitis resolved after discontinuation of the topical MMC and treatment with a topical corticosteroid.
authors.affiliation: Department of Ophthalmology, School of Medicine, Inonu University, Malatya, Turkey. tongabay@superonline.com
authors.forename: Tongabay
authors.initials: T
authors.lastname: Cumurcu
authors.forename: Serpil
authors.initials: S
authors.lastname: Sener
authors.forename: Mufide
authors.initials: M
authors.lastname: Cavdar
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000188:drug therapy / Q000473:pathology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D019557:Dermatitis, Perioral / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000903:Antibiotics, Antineoplastic; D009883:Ophthalmic Solutions; D016685:Mitomycin