title: Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN).
abstract: The purpose of this study is to predict the occurrence of transient tachypnea of the newborn (TTN) using amniotic lamellar body count (LBC) and compare the LBCs in neonates with TTN with the LBCs in neonates with respiratory distress syndrome (RDS) and controls.
  
  
  
  Three hundred and eighty-one amniotic fluid samples were obtained at cesarean section from 27 to 40 weeks of gestation. Samples were analyzed immediately without centrifugation and the number of lamellar bodies was counted.
  
  
  
  The LBC in amniotic fluid ranged from 1,000 to 577,000/μL. An LBC cut-off value of 48,500/μL resulted in 84.7% sensitivity, 76.2% specificity, and 98.1% negative predictive value for predicting TTN. The LBC in neonates with TTN was significantly lower than that in controls (50,000 vs. 122,000; P<0.001) and significantly higher than that in neonates with RDS (50,000 vs. 21,000; P=0.042).
  
  
  
  We established a cut-off value of LBC for predicting the occurrence of TTN. The LBC in neonates with TTN was significantly lower than that in controls. Amniotic LBC can be a useful marker to predict if neonatal respiratory management is required.
authors.affiliation: Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan. hiro-t@med.nagoya-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Shigenori
authors.initials: S
authors.lastname: Iwagaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Uchida
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawabata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Sumigama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kotani
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kikkawa
mesh_terms: D056809:Alveolar Epithelial Cells / Q000648:ultrastructure; D000653:Amniotic Fluid / Q000166:cytology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015388:Organelles / Q000648:ultrastructure; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D011663:Pulmonary Surfactants; D012120:Respiration Disorders / Q000175:diagnosis*; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis*
chemical_list: D011663:Pulmonary Surfactants