title: γ-Oryzanol recovers mouse hypoadiponectinemia induced by animal fat ingestion.
abstract: Adiponectin is an insulin-sensitizing adipocyte-derived adipokine. The decrease in plasma adiponectin level (hypoadiponectinemia) is involved in the development of insulin resistance and the resulting type 2 diabetes. Our previous studies have demonstrated that γ-oryzanol (ORZ) from rice bran suppressed NF-κB activation and increased adiponectin secretion from adipocyte. In this study, we have evaluated effects of oral administration of animal fat (beef tallow) and palmitate on mouse serum adiponectin level. Oral administrations of beef tallow and palmitate significantly suppressed serum adiponectin levels into around half of the initial level from 48 to 96 h after administration compared with the case of corn oil (P<0.05). Coadministration of ORZ successfully remedied mouse hypoadiponectinemia induced by ingestion of beef tallow and the relative adiponectin levels attained to 1.66±0.23 at 96 h after administration (mean value±s.e., P<0.05). Diverse physiological functions of ORZ in crop bran might be promising us to prevent chronic inflammations in the pathogeneses of the metabolic or insulin resistance syndromes.
authors.affiliation: Department of Food Science & Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Nagasaka
authors.forename: Tomoteru
authors.initials: T
authors.lastname: Yamsaki
authors.forename: Asako
authors.initials: A
authors.lastname: Uchida
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ohara
authors.forename: Hideki
authors.initials: H
authors.lastname: Ushio
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D052242:Adiponectin / Q000097:blood*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D004041:Dietary Fats / Q000008:administration & dosage*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012275:Oryza / Q000737:chemistry; D010168:Palmitates / Q000008:administration & dosage; D010666:Phenylpropionates / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D052242:Adiponectin; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010168:Palmitates; D010666:Phenylpropionates; D010936:Plant Extracts; C013172:gamma-oryzanol