title: A historical perspective on clinical trials innovation and leadership: where have the academics gone?
authors.affiliation: Department of Biostatistics and Medical Informatics, K6/446 Clinical Science Center, 600 Highland Ave, University of Wisconsin-Madison, Madison, WI 53792-4675, USA. demets@biostat.wisc.edu
authors.forename: David L
authors.initials: DL
authors.lastname: DeMets
authors.forename: Robert M
authors.initials: RM
authors.lastname: Califf
mesh_terms: D035843:Biomedical Research / Q000639:trends*; D004345:Drug Industry; D019317:Evidence-Based Medicine; D049673:History, 20th Century; D049674:History, 21st Century; D007857:Leadership; D009316:National Institutes of Health (U.S.); D016032:Randomized Controlled Trials as Topic / Q000266:history / Q000639:trends*; D012107:Research Design; D012577:Schools, Medical; D014481:United States; D014486:United States Food and Drug Administration