title: Translational research in neurology and neuroscience 2011: movement disorders.
abstract: We provide an update on the state of translational research in movement disorders, using examples of Huntington disease, Parkinson disease, and dystonia. While substantial progress in our understanding of these disorders has been achieved, development of neuroprotective treatments remains an unrealized goal. Here we highlight some of the emerging research areas that show the most promise for translational research in Huntington disease, Parkinson disease, and dystonia. Aetiology and pathogenesis, biomarker directions, and causal treatment opportunities are discussed for each disease, followed by a brief discussion drawing attention to important translational initiatives.
authors.affiliation: Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lübeck, Lübeck, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: Dimitri
authors.initials: D
authors.lastname: Krainc
authors.forename: Michael G
authors.initials: MG
authors.lastname: Schlossmacher
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
mesh_terms: D000818:Animals; D020821:Dystonic Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D009069:Movement Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D009462:Neurology / Q000379:methods / Q000639:trends*; D009488:Neurosciences / Q000379:methods / Q000639:trends*; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D057170:Translational Research, Biomedical / Q000379:methods* / Q000639:trends*