title: Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power.
abstract: A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.
authors.affiliation: Department of Psychology, University of Minnesota, Minneapolis, USA. derri023@umn.edu
authors.forename: Jaime
authors.initials: J
authors.lastname: Derringer
authors.forename: Robert F
authors.initials: RF
authors.lastname: Krueger
authors.forename: Niklas
authors.initials: N
authors.lastname: Manz
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: Ebony
authors.initials: E
authors.lastname: Bookman
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: John R
authors.initials: JR
authors.lastname: Kramer
authors.forename: Jay A
authors.initials: JA
authors.lastname: Tischfield
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Bierut
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology*; D002352:Carrier Proteins / Q000235:genetics*; D004569:Electroencephalography; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008565:Membrane Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D012146:Rest / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D008565:Membrane Proteins; C523897:SGIP1 protein, human