title: Calcium phosphate bone cement: a possible alternative to autologous bone graft. A radiological and biomechanical comparison in rat tibial bone.
abstract: BACKGROUND
  Donor site morbidity is a problem after autologous bone transplantation. An injectable CaP bone cement indicates properties similar to bone.
  
  
  METHODS
  Double osteotomies on rat tibias were performed. The intercalated segments were avascular (10), vascular (10), or avascular with Norian SRS(®) CaP bone cement replacing cancellous bone (10). Controls were non-operated contralateral tibias (15). All osteotomies were stabilised with an intra-medullary nail. After 8 weeks, all rats were killed. The harvested tibias were compared using X-ray, DEXA scanning, microCT scans and a biomechanical torsional test.
  
  
  RESULTS
  No difference in healing processes or biomechanical results has been found between the avascular bone graft, vascular bone graft and CaP bone cement groups.
  
  
  CONCLUSIONS
  The injectable CaP bone cement confirms its similarities to bone, implying that it can be used as an adjunct to secure bone fragments and as a possible alternative to autologous bone transplantation in clinical practice.
authors.affiliation: Department of Orthopaedic Surgery, Rikshospitalet, Oslo University Hospital, Sognsvannveien 20, Oslo, Norway. mona.winge@oslo-universitetssykehus.no
authors.forename: Mona I
authors.initials: MI
authors.lastname: Winge
authors.forename: Olav
authors.initials: O
authors.lastname: Reikerås
authors.forename: Magne
authors.initials: M
authors.lastname: Røkkum
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001696:Biomechanical Phenomena; D001843:Bone Cements; D016025:Bone Transplantation; D002130:Calcium Phosphates; D005592:Fracture Fixation / Q000379:methods*; D050723:Fractures, Bone / Q000601:surgery*; D008297:Male; D010027:Osteotomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019651:Plastic Surgery Procedures / Q000379:methods; D013977:Tibia / Q000000981:diagnostic imaging / Q000293:injuries / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D054159:Torsion, Mechanical; D014182:Transplantation, Autologous; D014945:Wound Healing
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; C496047:Norian SRS Cement