title: HIV and age do not substantially interact in HIV-associated neurocognitive impairment.
abstract: The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Forty-two percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status × age, both including dementia cases (p=0.12) and excluding dementia cases (p<0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with long-term infection. Further longitudinal studies are warranted.
authors.affiliation: Neurology Department, Xavier Building, Level 4, St. Vincent's Hospital, Darlinghurst, Sydney 2010, NSW, Australia. l.cysique@unsw.edu.au
authors.forename: Lucette A
authors.initials: LA
authors.lastname: Cysique
authors.forename: Paul
authors.initials: P
authors.lastname: Maruff
authors.forename: Margaret P
authors.initials: MP
authors.lastname: Bain
authors.forename: Edwina
authors.initials: E
authors.lastname: Wright
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Brew
mesh_terms: D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000523:psychology*; D000328:Adult; D000368:Aged; D000375:Aging / Q000523:psychology*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000523:psychology*; D015497:HIV-1; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies