title: Secondary pulmonary alveolar proteinosis in a patient with chronic myeloid leukemia in the accelerated phase.
abstract: Pulmonary alveolar proteinosis (PAP) is a rare respiratory disease the character of which is accumulation of protein consisting of surfactant in alveolar spaces. PAP sometimes complicates with hematological malignancies, especially myeloid leukemia. As one of the cause of PAP, impairment of alveolar macrophage is considered. We experienced a case of PAP with chronic myeloid leukemia (CML). 41 years old woman having CML for nine years developed PAP, and was treated by bronchoalveolar lavage and imatinib. She died of respiratory failure in the end, but BAL fluid had been becoming gradually crystalline after induction of imatinib. We consider that we should try to treat to improve respiratory status not only PAP but also hematological disease.
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Tokai University 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan. 8jmmd004@is.icc.u-tokai.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Ohmachi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ogiya
authors.forename: Fujiko
authors.initials: F
authors.lastname: Morita
authors.forename: Minoru
authors.initials: M
authors.lastname: Kojima
authors.forename: Kosuke
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Kei
authors.initials: K
authors.lastname: Tazume
authors.forename: Masamichi
authors.initials: M
authors.lastname: Komatsu
authors.forename: Naoki
authors.initials: N
authors.lastname: Hayama
authors.forename: Nobue
authors.initials: N
authors.lastname: Kumaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ando
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D018893:Bronchoalveolar Lavage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010879:Piperazines / Q000627:therapeutic use; D011649:Pulmonary Alveolar Proteinosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D011743:Pyrimidines / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate