title: Use of reduced dose rate when treating moving tumors using dynamic IMRT.
abstract: The purpose was to evaluate the effect of dose rate on discrepancies between expected and delivered dose caused by the interplay effect. Fifteen separate dynamic IMRT plans and five hybrid IMRT plans were created for five patients (three IMRT plans and one hybrid IMRT plan per patient). The impact of motion on the delivered dose was evaluated experimentally for each treatment field for different dose rates (200 and 400 MU/min), and for a range of target amplitudes and periods. The maximum dose discrepancy for dynamic IMRT fields was 18.5% and 10.3% for dose rates of 400 and 200 MU/min, respectively. The maximum dose discrepancy was larger than this for hybrid plans, but the results were similar when weighted by the contribution of the IMRT fields. The percentage of fields for which 98% of the target never experienced a 5% or 10% dose discrepancy increased when the dose rate was reduced from 400 MU/min to 200 MU/min. For amplitudes up to 2 cm, reducing the dose rate to 200 MU/min is effective in keeping daily dose discrepancies for each field within 10%.
authors.affiliation: Department of Radiation Oncology, Dana-Farber/Brigham & Women’s Cancer Center, Boston MA, USA. lecourt@mdanderson.org
authors.forename: Laurence
authors.initials: L
authors.lastname: Court
authors.forename: Matthew
authors.initials: M
authors.lastname: Wagar
authors.forename: Madeleine
authors.initials: M
authors.lastname: Bogdanov
authors.forename: Dan
authors.initials: D
authors.lastname: Ionascu
authors.forename: Deborah
authors.initials: D
authors.lastname: Schofield
authors.forename: Aaron
authors.initials: A
authors.lastname: Allen
authors.forename: Ross
authors.initials: R
authors.lastname: Berbeco
authors.forename: Tania
authors.initials: T
authors.lastname: Lingos
mesh_terms: D006801:Humans; D009038:Motion; D009369:Neoplasms / Q000532:radiotherapy*; D058958:Organs at Risk / Q000528:radiation effects; D011829:Radiation Dosage; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D013997:Time Factors