title: Synthesis of X(Y)-(EO)(n)-OCH₃ type heterobifunctional and X(Y)-(EO)(n)-Z type heterotrifunctional poly(ethylene glycol)s.
abstract: A synthetic route to prepare acetal-protected heterobifunctional poly(ethylene glycol), allyl(1-ethoxyethoxy)-PEG-OH (allyl(EE)-PEG-OH), was successfully established using a newly synthesized initiator, trimethylolpropane allyl (1-ethoxyethoxy) ether (TMPAEEE). Heterobifunctional allyl(OH)-mPEG and heterotrifunctional allyl(OH)-PEG-alkyne were obtained, respectively, after modification from this precursor polymer. The polymers were characterized by SEC, ¹H NMR, and MALDI-TOF mass spectroscopy. This approach is applicable for synthesizing a wide variety of X(Y)-(EO)(n)-OCH₃ type heterobifunctional and X(Y)-(EO)(n)-Z type heterotrifunctional PEGs.
authors.affiliation: Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Chau
mesh_terms: D000080:Acetals / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry*; D058105:Polymerization; D011409:Propylene Glycols / Q000737:chemistry
chemical_list: D000080:Acetals; D003432:Cross-Linking Reagents; D004987:Ethers; D011409:Propylene Glycols; C018163:trimethylolpropane; D011092:Polyethylene Glycols