title: Anti-TNF therapy using etanercept suppresses degenerative and inflammatory changes in skeletal muscle of older SJL/J mice.
abstract: Limb-girdle muscular dystrophy 2B and Miyoshi myopathy are characterized by muscle fiber necrosis caused by a defect in dysferlin and inflammatory changes. SJL/J mice are deficient in dysferlin and display severe inflammatory changes, most notably the presence of cytokines, which may be related to destruction of the sarcolemma. We tested the hypothesis that tumor necrosis factor (TNF) contributes to myofibril necrosis. Administration of etanercept, an agent that blocks TNF, resulted in dose-dependent reductions in inflammatory change, necrosis, and fatty/fibrous change. These findings indicate that TNF does indeed play a role in the damage to muscle in SJL/J mice and that etanercept has the potential to reduce such damage.
authors.affiliation: Division of Neurology, Department of Internal Medicine, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nemoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Konno
authors.forename: Hideki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakazora
authors.forename: Nobuatsu
authors.initials: N
authors.lastname: Nomoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Murata
authors.forename: Hisao
authors.initials: H
authors.lastname: Kitazono
authors.forename: Toshiki
authors.initials: T
authors.lastname: Fujioka
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004195:Disease Models, Animal; D000073939:Dysferlin; D000068800:Etanercept; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000276:immunology* / Q000473:pathology; D049288:Muscular Dystrophies, Limb-Girdle / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C497505:Dysf protein, mouse; D000073939:Dysferlin; D007074:Immunoglobulin G; D008565:Membrane Proteins; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept