title: Review article: the pathophysiology, differential diagnosis and management of rumination syndrome.
abstract: BACKGROUND
  Rumination syndrome, characterised by the effortless, often repetitive, regurgitation of recently ingested food into the mouth, was originally described in children and in the developmentally disabled. It is now well-recognised that rumination syndrome occurs in patients of all ages and cognitive abilities.
  
  
  OBJECTIVE
  To review a scholarly review on our current understanding of the rumination syndrome.
  
  
  METHODS
  The review was conducted on the basis of a medline search to identify relevant publications pertaining to the pathophysiology, clinical diagnosis and management of rumination syndrome.
  
  
  RESULTS
  The Rome III consensus established diagnostic criteria for rumination syndrome in adults, children and infants. A typical history can be highly suggestive but oesophageal (high resolution) manometry/impedance with ingestion of a meal may help to distinguish rumination syndrome from other belching/regurgitation disorders. The pathophysiology is incompletely understood, but involves a rise in intra-gastric pressure, generated by a voluntary, but often unintentional, contraction of the abdominal wall musculature, at a time of low pressure in the lower oesophageal sphincter, causing retrograde movement of gastric contents into the oesophagus. To date, controlled trials in the treatment rumination syndrome are lacking. The mainstay of treatment for rumination syndrome is explanation and behavioural treatment which consists of habit reversal techniques that compete with the urge to regurgitate. Chewing gum, prokinetics, baclofen and even antireflux surgery have been proposed as adjunctive therapies, but high quality studies are generally lacking.
  
  
  CONCLUSIONS
  Rumination is an under-recognised condition with incompletely understood pathophysiology. Behavioural therapy seems effective, but controlled treatment trials are lacking.
authors.affiliation: Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, Leuven, Vlaanderen, Belgium. jan.tack@med.kuleuven.be
authors.forename: J
authors.initials: J
authors.lastname: Tack
authors.forename: K
authors.initials: K
authors.lastname: Blondeau
authors.forename: V
authors.initials: V
authors.lastname: Boecxstaens
authors.forename: N
authors.initials: N
authors.lastname: Rommel
mesh_terms: D000293:Adolescent; D000328:Adult; D002032:Bulimia / Q000503:physiopathology / Q000628:therapy; D002648:Child; D003937:Diagnosis, Differential; D004884:Eructation / Q000503:physiopathology / Q000628:therapy; D005764:Gastroesophageal Reflux / Q000503:physiopathology* / Q000628:therapy; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D013577:Syndrome; D014839:Vomiting / Q000503:physiopathology / Q000628:therapy