title: Comparison of histopathologic classification and surgical stage by cytokeratin 8 and cytokeratin 18 in endometrial cancer.
abstract: OBJECTIVE
  The aim of the study was to show the role of the cytoskeletal proteins CK8 and CK18 in endometrial cancer invasion and to histopathologically classify endometrial cancer patients.
  
  
  METHODS
  This study was a prospective analysis of 49 histologic samples of consecutively surgically operated endometrial cancer patients. After histopathologic classification the most invasive tumor area was selected for immunohistochemistry. Monoclonal antihuman keratin Ab-4 and keratin Ab-1 were applied.
  
  
  RESULTS
  CK8 and CK18 stained tumoral tissue and tumoral cell debris in the lymphovascular space were significantly correlated with stage (p < or = 0.005).
  
  
  CONCLUSIONS
  To understand the causes of early treatment failure in endometrial cancer patients, further studies are needed to show the role of enhancing factors of endometrial cancer invasion.
authors.affiliation: Department of Pathology, University of Osmangazi School of Medicine, Eskisehir, Turkey. skabukcuoglu@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Kabukcuoglu
authors.forename: S S
authors.initials: SS
authors.lastname: Ozalp
authors.forename: O T
authors.initials: OT
authors.lastname: Yalcin
authors.forename: E
authors.initials: E
authors.lastname: Colak
authors.forename: A A
authors.initials: AA
authors.lastname: Abubakar
mesh_terms: D000368:Aged; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000145:classification* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053538:Keratin-18 / Q000145:classification / Q000378:metabolism*; D053533:Keratin-8 / Q000145:classification / Q000378:metabolism*; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D053538:Keratin-18; D053533:Keratin-8