title: [Expression and clinicopathological significance of CD44V6 expression in non-small cell lung cancer].
abstract: BACKGROUND
  To study the expression and clinicopathological significance of CD44V6 in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  CD44V6 expression in lung cancer tissues was detected in 90 patients with lung cancer by immunohistohemistry SABC method.
  
  
  RESULTS
  The positive rate of CD44V6 expression in NSCLC was 51.1% (46/90), which was related to TNM stage, but not to cell differention, age and sex of the patients (P > 0.05). The positive rate of CD44V6 expression was 32.2% (10/31) in stage I+II patients and 61.0% (36/59) in stage III+IV disease. A highly significant difference was existed between the two groups (P < 0.01). The positive rate of CD44V6 expression was significantly higher in NSCLC with lymph node metastasis (61.0%, 36/59) than that without lymph node metastasis (32.2%, 10/31) (P < 0.01). The 3-year survival rate (65.5%, 19/29) in patients with low CD44V6 expression was significantly higher than that (35.0%, 7/20) with high CD44V6 expression (P < 0.05).
  
  
  CONCLUSIONS
  Overexpression of CD44V6 may be involved in the progression and metastasis of the cancer and prognosis of the patients with lung cancer. It might be helpful to evaluate the progression of the cancer, and to predict the metastasis and progression of lung cancer.
authors.affiliation: Department of Respiration, Shanxi Province People's Hospital, Xi'an, Shanxi 710068, P.R.China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Han
authors.forename: Juntao
authors.initials: J
authors.lastname: Yao
authors.forename: Shuanying
authors.initials: S
authors.lastname: Yang
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Ren