title: Repeated intracoronary infusion of peripheral blood stem cells with G-CSF in patients with refractory ischemic heart failure--a pilot study.
abstract: BACKGROUND
  Recent investigations have suggested the clinical efficacy of granulocyte colony-stimulating factor (G-CSF) infusion alone or in combination with a single dose delivery of peripheral blood stem cells (PBSC) infusion in patients with myocardial infarction (MI) and congestive heart failure (HF). The current study tested the feasibility and effect of repeated intracoronary infusions PBSC and the mobilization of G-CSF in patients with refractory HF after MI.
  
  
  RESULTS
  Patients with recent large MI and a lower left ventricular ejection fraction (LVEF) were enrolled into one of the following 3 groups: Group R (n=15) received repeated intracoronary infusion of PBSC and one-dose of G-CSF; Group S (n=15) received a single infusion of PBSC and a G-CSF dose; and Group C (n=15) received neither PBSC nor a G-CSF dose. Cardiac performance was evaluated by echocardiography and single photon-emission computed tomography (SPECT). All the patients underwent 12-month follow-up. LVEF in Group R (47.00±4.90%) was significantly higher than that in Group S (44.40±3.87%, P<0.01) and Group C (40.80±3.41%, P<0.01). Similarly, the improvement of myocardial perfusion assessed by SPECT in Group R was more than that in Group S (P=0.012) and Group C (P<0.01). Neither death nor new MI occurred.
  
  
  CONCLUSIONS
  Repeated intracoronary infusions of PBSC plus mobilization of G-CSF might be an optional effective strategy for treating patients with refractory HF after recent large MI.
authors.affiliation: Department of Cardiology, Northern People’s Hospital, Medical College of Yangzhou University, Nantong West Road 98, Yangzhou 225001, China. sbyygx@medmail.com.cn
authors.forename: Xiang
authors.initials: X
authors.lastname: Gu
authors.forename: Yong
authors.initials: Y
authors.lastname: Xie
authors.forename: Jian
authors.initials: J
authors.lastname: Gu
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.forename: Shenghu
authors.initials: S
authors.lastname: He
authors.forename: Rixin
authors.initials: R
authors.lastname: Xu
authors.forename: Junfei
authors.initials: J
authors.lastname: Duan
authors.forename: Jianye
authors.initials: J
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: Hang
authors.forename: Houtian
authors.initials: H
authors.lastname: Xu
authors.forename: Minghui
authors.initials: M
authors.lastname: Li
authors.forename: Kejiang
authors.initials: K
authors.lastname: Cao
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Geng
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000009:adverse effects; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D010865:Pilot Projects; D011446:Prospective Studies; D014182:Transplantation, Autologous
chemical_list: D016179:Granulocyte Colony-Stimulating Factor