title: Preparation of a versatile bifunctional zeolite for targeted imaging applications.
abstract: Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecular targeting vectors (e.g., peptides, aptamers) to the zeolite surface. The modified particle efficiently incorporates the imaging radioisotope gallium-68 ((68)Ga) into the pores of the azide-functionalized NaY zeolite to form a stable bifunctional molecular targeting vector. The result is a versatile "clickable" zeolite platform that can be tailored for future in vivo molecular targeting and imaging modalities.
authors.affiliation: Department of Chemistry, University of Iowa , Iowa City, Iowa 52242, United States.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Ndiege
authors.forename: Renugan
authors.initials: R
authors.lastname: Raidoo
authors.forename: Michael K
authors.initials: MK
authors.lastname: Schultz
authors.forename: Sarah
authors.initials: S
authors.lastname: Larsen
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D057930:Click Chemistry; D008958:Models, Molecular; D057054:Molecular Imaging; D015394:Molecular Structure; D013499:Surface Properties; D017641:Zeolites / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D017641:Zeolites