title: Soluble CD40 ligand and prolactin levels in migraine patients during interictal period.
abstract: The relationship of migraine with cardiovascular diseases has been clarified by many studies, and currently, migraine is suggested to be a systematic vasculopathy. Inflammation, thrombosis and impaired vascular reactivity are the underlying pathophysiological mechanisms of the vasculopathy. In the present study, we aimed to investigate the relationship between prolactin levels and subclinical atherosclerosis risk factors such as soluble CD40 ligand (sCD40L) and high-sensitivity CRP (hsCRP) in migraine patients during interictal period. Fifty female migraine patients and age-matched 25 female control cases were enrolled in the study. Migraine diagnosis was settled according to the ICHD-II diagnostic criteria. A questionnaire was completed about the existence of vascular risk factors. Serum samples were used to measure sCD40L, hsCRP and prolactin levels. No difference was found between the prolactin levels of the migraine patients and the controls. The sCD40L levels were significantly higher in migraine patients (p < 0.001). High-sensitivity CRP levels showed no difference between the groups. There was no correlation between prolactin, sCD40L, and hs-CRP levels in migraine patients. We consider that the migraine patients are prone to subclinical atherosclerosis, but this tendency is independent of prolactin levels.
authors.affiliation: Department of Endocrinology, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Guldiken
authors.forename: Baburhan
authors.initials: B
authors.lastname: Guldiken
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Demir
authors.forename: Levent
authors.initials: L
authors.lastname: Kabayel
authors.forename: Hulya
authors.initials: H
authors.lastname: Ozkan
authors.forename: Nilda
authors.initials: N
authors.lastname: Turgut
authors.forename: Remziye
authors.initials: R
authors.lastname: Hunkar
authors.forename: Selahattin
authors.initials: S
authors.lastname: Kat
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood*; D005260:Female; D006801:Humans; D008881:Migraine Disorders / Q000453:epidemiology / Q000378:metabolism*; D011388:Prolactin / Q000097:blood*; D012307:Risk Factors; D012995:Solubility; D011795:Surveys and Questionnaires; D014657:Vasculitis / Q000453:epidemiology / Q000378:metabolism*; D055815:Young Adult
chemical_list: D023201:CD40 Ligand; D011388:Prolactin; D002097:C-Reactive Protein