title: Non-surgical instrumentation associated with povidone-iodine in the treatment of interproximal furcation involvements.
abstract: OBJECTIVE
  The aim of this controlled clinical trial was to evaluate the effect of topically applied povidone-iodine (PVP-I) used as an adjunct to non-surgical treatment of interproximal class II furcation involvements.
  
  
  METHODS
  Thirty-two patients presenting at least one interproximal class II furcation involvement that bled on probing with probing pocket depth (PPD) ≥ 5 mm were recruited. Patients were randomly chosen to receive either subgingival instrumentation with an ultrasonic device using PVP-I (10%) as the cooling liquid (test group) or identical treatment using distilled water as the cooling liquid (control group). The following clinical outcomes were evaluated: visible plaque index, bleeding on probing (BOP), position of the gingival margin, relative attachment level (RAL), PPD and relative horizontal attachment level (RHAL). BAPNA (N-benzoyl-L-arginine-p-nitroanilide) testing was used to analyze trypsin-like activity in dental biofilm. All parameters were evaluated at baseline and 1, 3 and 6 months after non-surgical subgingival instrumentation.
  
  
  RESULTS
  Six months after treatment, both groups had similar means of PPD reduction, RAL and RHAL gain (p>0.05). These variables were, respectively, 2.20 ± 1.10 mm, 1.27 ± 1.02 mm and 1.33 ± 0.85 mm in the control group and 2.67 ± 1.21 mm, 1.50 ± 1.09 mm and 1.56 ± 0.93 mm in the test group. No difference was observed between groups at none of the posttreatment periods, regarding the number of sites showing clinical attachment gain ≥ 2 mm. However, at 6 months posttreatment, the test group presented fewer sites with PPD ≥ 5 mm than the control group. Also at 6 months the test group had lower BAPNA values than control group.
  
  
  CONCLUSIONS
  The use of PVP-I as an adjunct in the non-surgical treatment of interproximal class II furcation involvements provided limited additional clinical benefits.
authors.affiliation: Bahiana School of Medicine and Public Health, Salvador, BA, Brazil.
authors.forename: Erica Del Peloso
authors.initials: Edel P
authors.lastname: Ribeiro
authors.forename: Sandro
authors.initials: S
authors.lastname: Bittencourt
authors.forename: Enilson Antônio
authors.initials: EA
authors.lastname: Sallum
authors.forename: Antônio Wilson
authors.initials: AW
authors.lastname: Sallum
authors.forename: Francisco Humberto
authors.initials: FH
authors.lastname: Nociti
authors.forename: Márcio Zaffalon
authors.initials: MZ
authors.lastname: Casati
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D001586:Benzoylarginine Nitroanilide; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000188:drug therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014464:Ultrasonic Therapy
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; D001586:Benzoylarginine Nitroanilide