title: A view on imaging in drug research and development for respiratory diseases.
abstract: With the incidence of respiratory diseases increasing throughout the world, new therapies are needed. This review provides a short overview of different imaging techniques of interest for drug discovery and development within the pulmonary disease area. The focus is on studies performed in both animals and humans, which are of importance for understanding pathophysiological aspects and evaluating new drugs. Rather than emphasizing particular lung diseases, the noninvasive diagnosis and quantification of a number of characteristics related to several pathological conditions of the lung are addressed: inflammation, mucus secretion and clearance, emphysema, ventilation, perfusion, fibrosis, airway remodeling, and pulmonary arterial hypertension. Techniques are discussed based on their present use or potential future utilization in the context of drug studies.
authors.affiliation: Novartis Institutes for BioMedical Research, Clinical Imaging Group, Basel, Switzerland. nicolau.beckmann@novartis.com
authors.forename: Cees J A
authors.initials: CJ
authors.lastname: van Echteld
authors.forename: Nicolau
authors.initials: N
authors.lastname: Beckmann
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003952:Diagnostic Imaging / Q000379:methods*; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000473:pathology; D007249:Inflammation / Q000175:diagnosis / Q000473:pathology; D008168:Lung / Q000473:pathology* / Q000502:physiology; D008279:Magnetic Resonance Imaging; D009079:Mucociliary Clearance / Q000502:physiology; D009093:Mucus / Q000378:metabolism; D010601:Pharmacology, Clinical / Q000379:methods*; D011652:Pulmonary Circulation / Q000502:physiology; D011658:Pulmonary Fibrosis / Q000188:drug therapy / Q000473:pathology; D015656:Respiratory Mechanics; D012140:Respiratory Tract Diseases / Q000188:drug therapy* / Q000473:pathology*