title: Temporal dynamics of cerebrospinal fluid anti-aquaporin-4 antibodies in patients with neuromyelitis optica spectrum disorders.
abstract: Neuromyelitis optica spectrum disorders (NMOSD) are associated with anti-aquaporin-4 autoantibodies (AQP4-IgG). Limited data is available on longitudinal cerebrospinal fluid (CSF) AQP4-IgG and their relation to disease activity and inflammatory parameters. AQP4-IgG titers were measured in matched longitudinal serum and CSF samples of 12 patients with NMOSD by an immunofluorescence assay and correlated with clinical parameters. CSF AQP4-IgG were present in patients with high serum titers and correlated with spinal MRI lesion length and CSF parameters. Clinical improvement was associated with a decrease in CSF, but not serum, AQP4-IgG titers. Thus, CSF AQP4-IgG were associated with clinical activity and neuroinflammation.
authors.affiliation: Clinic of Neurology, Clinical Center of Serbia, Belgrade, Serbia.
authors.forename: Irena
authors.initials: I
authors.lastname: Dujmovic
authors.forename: Simone
authors.initials: S
authors.lastname: Mader
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schanda
authors.forename: Florian
authors.initials: F
authors.lastname: Deisenhammer
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Stojsavljevic
authors.forename: Jelena
authors.initials: J
authors.lastname: Kostic
authors.forename: Thomas
authors.initials: T
authors.lastname: Berger
authors.forename: Jelena
authors.initials: J
authors.lastname: Drulovic
authors.forename: Markus
authors.initials: M
authors.lastname: Reindl
mesh_terms: D000328:Adult; D000368:Aged; D051401:Aquaporin 4 / Q000276:immunology*; D002452:Cell Count / Q000379:methods; D002461:Cell Line, Transformed; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000097:blood / Q000134:cerebrospinal fluid*; D017711:Nonlinear Dynamics; D055815:Young Adult
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D007074:Immunoglobulin G