title: Enantioselective synthesis of axially chiral hydroxy carboxylic acid derivatives by rhodium-catalyzed [2 + 2 + 2] cycloaddition.
abstract: Axially chiral hydroxy carboxylic acid derivatives were successfully synthesized with high yields and ee values by the cationic rhodium(I)/axially chiral biaryl bisphosphine complex-catalyzed enantioselective [2 + 2 + 2] cycloaddition. Axially chiral hydroxy and dihydroxy carboxylic acid derivatives, bearing the aryl group at the ortho-position of the alkoxycarbonyl group, were also synthesized with high regio- and enantioselectivity.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Ogaki
authors.forename: Yu
authors.initials: Y
authors.lastname: Shibata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Noguchi
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka