title: Design, synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes.
abstract: Five dinuclear platinum(II) complexes with a novel chiral ligand, 2-(((1R,2R)-2-aminocyclohexylamino)methyl)phenol (HL), were designed, prepared and spectrally characterized. In vitro cytotoxicity of all the resulting platinum(II) compounds was evaluated against human HEPG-2, A549 and HCT-116 cell lines, respectively. Results indicated that all compounds showed positive biological activity. Particularly, compound D4 has lower IC(50) values than carboplatin toward HEPG-2 and A549, while compound D5 shows better activity than carboplatin against A549.
authors.affiliation: Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
authors.forename: Chuanzhu
authors.initials: C
authors.lastname: Gao
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gou
authors.forename: Lei
authors.initials: L
authors.lastname: Fang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
mesh_terms: D002460:Cell Line; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D017671:Platinum Compounds