title: A new, convenient cell-based screening method for small-molecule glycolytic inhibitors.
abstract: To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.
authors.affiliation: Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Mayuko
authors.initials: M
authors.lastname: Misawa
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Ogawa
authors.forename: Etsu
authors.initials: E
authors.lastname: Tashiro
authors.forename: Masaya
authors.initials: M
authors.lastname: Imoto
mesh_terms: D001692:Biological Transport / Q000187:drug effects; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D054852:Small Molecule Libraries / Q000494:pharmacology*
chemical_list: D054852:Small Molecule Libraries; D005947:Glucose