title: Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.
abstract: Mechanisms that ensure robust long-term performance of synaptic transmission over a wide range of activity are crucial for the integrity of neuronal networks, for processing sensory information and for the ability to learn and store memories. Recent experiments have revealed that such robust performance requires a tight coupling between exocytic vesicle fusion at defined release sites and endocytic retrieval of synaptic vesicle membranes. Distinct presynaptic scaffolding proteins are essential for fulfilling this requirement, providing either ultrastructural coordination or acting as signalling hubs.
authors.affiliation: Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität, and Charité Universitätsmedizin Berlin, Takustraße 6, 14195 Berlin, Germany. volker.haucke@fu‑berlin.de
authors.forename: Volker
authors.initials: V
authors.lastname: Haucke
authors.forename: Erwin
authors.initials: E
authors.lastname: Neher
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Sigrist
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D045170:Matrix Attachment Regions / Q000502:physiology*; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology; D013572:Synaptic Vesicles / Q000502:physiology / Q000648:ultrastructure