title: Communication between 5-HT and small GTPases.
abstract: Advances over the past decade have improved our understanding of the serotonin (5-HT) biology outside the central nervous system specifically the molecular mechanisms of serotonergic signaling in association with small GTPases. It is now recognized that the communication between 5-HT and GTPases plays important roles in peripheral tissues, vascular cells and are involved in coagulation, hypertension, inflammation, healing and protection. Furthermore, 5-HT receptors as heterotrimeric GTP-binding protein-coupled receptors act as effector protein on the small GTPases. Therefore, the antagonists or agonists of the effector proteins of small GTPases could be useful therapeutic agents for the treatment of several diseases and disorders.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
authors.forename: Charles P
authors.initials: CP
authors.lastname: Mercado
authors.forename: Endrit
authors.initials: E
authors.lastname: Ziu
authors.forename: Fusun
authors.initials: F
authors.lastname: Kilic
mesh_terms: D000818:Animals; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; D020559:Monomeric GTP-Binding Proteins