title: Intratympanic gentamicin in Ménière's disease: our experience.
abstract: OBJECTIVE
  To analyse intratympanic gentamicin injection as a treatment option in patients with monolateral Ménière's disease resistant to medical treatment.
  
  
  METHODS
  Longitudinal, prospective, descriptive study of response to gentamicin treatment in 71 patients diagnosed with Ménière's disease and treated medically for more than a year, unsuccessfully. American Academy of Otolaryngology-Head and Neck Surgery criteria were used for diagnosis and follow up.
  
  
  RESULTS
  Complete vertigo control was obtained in 65.6 per cent of patients, and complete or substantial control in 84.37 per cent. Thirteen patients (18.3 per cent) suffered significant hearing loss.
  
  
  CONCLUSIONS
  This intratympanic gentamicin injection protocol enabled effective vertigo control in most patients, and represents a good alternative to more aggressive techniques for the treatment of Ménière's disease which does not respond to medical treatment.
authors.affiliation: Otorhinolaryngology, Miguel Servet University Hospital, Zaragoza, Spain. layipez@hotmail.com
authors.forename: L Pérez
authors.initials: LP
authors.lastname: Delgado
authors.forename: J Fraile
authors.initials: JF
authors.lastname: Rodrigo
authors.forename: P Astier
authors.initials: PA
authors.lastname: Peña
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004812:Epidemiologic Methods; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D055502:Secondary Prevention; D016896:Treatment Outcome; D014432:Tympanic Membrane
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins