title: Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome.
abstract: Studies on cytokine levels in Weil's syndrome are lacking. In this study, TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels were measured in 44 serum samples of patients diagnosed with Leptospira interrogans serovar icterohaemorrhagiae infection. TNF-α levels linked with pulmonary hemorrhagic implications, while elevated sTNFR1 and IL-10 levels linked with fatal cases. IL-6 and IL-8 did not seem to affect the outcome of the disease. Immune response pattern in Weil's syndrome bears resemblance to other patterns described for hemorrhagic fevers. IL-10/TNF-α ratio is proposed as a marker for prognosis.
authors.affiliation: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. kyriakidis@auth.gr
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kyriakidis
authors.forename: Pinelopi
authors.initials: P
authors.lastname: Samara
authors.forename: Anna
authors.initials: A
authors.lastname: Papa
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D007922:Leptospirosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10