title: Measurement of polyamine pKa values.
abstract: The extent of ionization of the polyamines is an important factor in their interactions with cellular components. The pK(a) is the pH at which a functional group is 50% ionized. For compounds such as polyamines with more than one ionizable center (atom or functional group), there is a pK(a) value for each center of ionization. This chapter describes the pK(a) values for each amine group in many important polyamines, the factors influencing these values and methods for their determination using potentiometric titration and nuclear magnetic resonance spectroscopy.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
authors.forename: Ian S
authors.initials: IS
authors.lastname: Blagbrough
authors.forename: Abdelkader A
authors.initials: AA
authors.lastname: Metwally
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Geall
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D011073:Polyamines / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry; D011199:Potentiometry / Q000379:methods*
chemical_list: D000617:Aminoglycosides; D011073:Polyamines; D011094:Polyethyleneimine