title: MicroRNA-542-5p as a novel tumor suppressor in neuroblastoma.
abstract: Several studies have implicated the dysregulation of microRNAs in neuroblastoma pathogenesis, an often fatal paediatric cancer arising from precursor cells of the sympathetic nervous system. Our group and others have demonstrated that lower expression of miR-542-5p is highly associated with poor patient survival, indicating a potential tumor suppressive function. Here, we demonstrate that ectopic over-expression of this miRNA decreases the invasive potential of neuroblastoma cell lines in vitro, along with primary tumor growth and metastases in an orthotopic mouse xenograft model, providing the first functional evidence for the involvement of miR-542-5p as a tumor suppressor in any type of cancer.
authors.affiliation: Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland.
authors.forename: Isabella
authors.initials: I
authors.lastname: Bray
authors.forename: Amanda
authors.initials: A
authors.lastname: Tivnan
authors.forename: Kenneth
authors.initials: K
authors.lastname: Bryan
authors.forename: Niamh H
authors.initials: NH
authors.lastname: Foley
authors.forename: Karen M
authors.initials: KM
authors.lastname: Watters
authors.forename: Lorraine
authors.initials: L
authors.lastname: Tracey
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davidoff
authors.forename: Raymond L
authors.initials: RL
authors.lastname: Stallings
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D048708:Cell Growth Processes / Q000235:genetics; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D046228:Microarray Analysis; D009447:Neuroblastoma / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D016019:Survival Analysis; D014162:Transfection
chemical_list: C572448:MIRN542 microRNA, mouse; D035683:MicroRNAs