title: Effect of surgical fit on integration of cancellous bone and implant cortical bone shear strength for a porous titanium.
abstract: Porous scaffold dowels of Ti(6)Al(4)V were prepared and implanted into cancellous and cortical bone sites in adult sheep. Cancellous implants were examined under gap, line-to-line, and press-fit conditions, whereas line-to-line implantation was used in cortical sites. Cortical shear strength increased significantly with time and reached 26.1 ± 8.6 MPa at 12 weeks, accompanied by a concomitant increase in bone integration and remodeling. In cancellous sites, bone integration was well established at 4 and 12 weeks under conditions of press-fit and line-to-line match between implant and surgical defect. New bone growth was also found in the gap conditions, although to a lesser extent. These findings suggest that the porous Ti(6)Al(4)V could prove an effective scaffold material for uncemented fixation in cortical and cancellous sites.
authors.affiliation: Surgical and Orthopaedic Research Laboratories-University of New South Wales, Sydney, Australia.
authors.forename: Nicky
authors.initials: N
authors.lastname: Bertollo
authors.forename: Masaaki
authors.initials: M
authors.lastname: Matsubara
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shinoda
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Mukesh
authors.initials: M
authors.lastname: Kumar
authors.forename: William R
authors.initials: WR
authors.lastname: Walsh
mesh_terms: D000497:Alloys; D000818:Animals; D005269:Femur / Q000502:physiology / Q000601:surgery*; D008297:Male; D016348:Osseointegration; D016062:Porosity; D019736:Prostheses and Implants; D033081:Shear Strength; D012756:Sheep; D013977:Tibia / Q000502:physiology / Q000601:surgery*; D014025:Titanium
chemical_list: D000497:Alloys; C031462:titanium alloy (TiAl6V4); D014025:Titanium