title: [Pharmacovigilance update].
abstract: Main pharmacovigilance updates are reviewed. Rosiglitazone and sibutramine have been suspended due to cardiovascular risks. The safety profile of H1N1 vaccines is similar to the established profile of seasonal influenza vaccines. Paroxetine reduces the benefit of tamoxifen. The use of serotoninergic antidepressants in pregnancy is still disputed. The risk of venous thromboembolism could be higher with oral combined contraceptives containing drospirenone compared to those containing levonorgestrel. Prolonged QT and PR intervals have been observed with saquinavir. The correct use of transdermal patches is reviewed with the example of rivastigmine. Aseptic meningitis is a rare adverse reaction of lamotrigine. An increased risk of fractures after long term use of proton pump inhibitors is suspected.
authors.affiliation: Division de pharmacologie et toxicologie cliniques, Département de médecine, CHUV, 1011 Lausanne. francoise.livio@chuv.ch
authors.forename: F
authors.initials: F
authors.lastname: Livio
authors.forename: J
authors.initials: J
authors.lastname: Biollaz
authors.forename: T
authors.initials: T
authors.lastname: Buclin
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D011247:Pregnancy; D011358:Product Surveillance, Postmarketing