title: Vesicular stomatitis virus-based H5N1 avian influenza vaccines induce potent cross-clade neutralizing antibodies in rhesus macaques.
abstract: We analyzed the ability of a vaccine vector based on vesicular stomatitis virus (VSV) to induce a neutralizing antibody (NAb) response to avian influenza viruses (AIVs) in rhesus macaques. Animals vaccinated with vectors expressing either strain A/Hong Kong/156/1997 or strain A/Vietnam/1203/2004 H5 hemagglutinin (HA) were able to generate robust NAb responses. The ability of the vectors to induce NAbs against homologous and heterologous AIVs after a single dose was dependent upon the HA antigen incorporated into the VSV vaccine. The vectors expressing strain A/Vietnam/1203/2004 H5 HA were superior to those expressing strain A/Hong Kong/156/1997 HA at inducing cross-clade NAbs.
authors.affiliation: Department of Pathology, Yale University School of Medicine, 310 Cedar St. LH 315, New Haven, CT 06520, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Schwartz
authors.forename: Linda
authors.initials: L
authors.lastname: Buonocore
authors.forename: Amorsolo
authors.initials: A
authors.lastname: Suguitan
authors.forename: Meredith
authors.initials: M
authors.lastname: Hunter
authors.forename: Preston A
authors.initials: PA
authors.lastname: Marx
authors.forename: Kanta
authors.initials: K
authors.lastname: Subbarao
authors.forename: John K
authors.initials: JK
authors.lastname: Rose
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood; D003429:Cross Reactions; D004337:Drug Carriers; D005822:Genetic Vectors; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000235:genetics / Q000276:immunology*; D008253:Macaca mulatta; D018116:Vesiculovirus / Q000235:genetics*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D004337:Drug Carriers; D007252:Influenza Vaccines