title: Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival.
abstract: Background. Optimal treatment of nongastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) is resection with wide margins. This study investigates the prognostic impact of the angiogenesis-associated platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in non-GIST STS patients with wide and nonwide resection margins. Method. Tumor samples and clinical data from 249 patients with non-GIST STS were obtained, and tissue microarrays were constructed for each specimen. Immunohistochemistry was used to evaluate the expression of PDGF-A, -B, -C, and -D and PDGFR-α and -β. Results. In the multivariate analysis of patients with wide resection margins, high expression of PDGF-B (P = .013, HR = 2.954, and 95% CI = 1.255-6.956) and the coexpression of PDGF-B and PDGFR-α (overall; P = .016, high-low/low-high; P = .051, HR = 2.678, 95% CI = 0.996-7.200, high/high; P = .004, HR = 3.930, 95% CI = 1.542-10.015) were independent negative prognostic markers for disease-specific survival. Conclusion. PDGF-B and the coexpression of PDGF-B and PDGFR-α are strong and independent prognostic factors in non-GIST STSs with wide resection margins.
authors.affiliation: Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway.
authors.forename: Thomas Karsten
authors.initials: TK
authors.lastname: Kilvaer
authors.forename: Andrej
authors.initials: A
authors.lastname: Valkov
authors.forename: Sveinung W
authors.initials: SW
authors.lastname: Sorbye
authors.forename: Tom
authors.initials: T
authors.lastname: Donnem
authors.forename: Eivind
authors.initials: E
authors.lastname: Smeland
authors.forename: Roy Martin
authors.initials: RM
authors.lastname: Bremnes
authors.forename: Lill-Tove
authors.initials: LT
authors.lastname: Busund