title: A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor.
abstract: BACKGROUND
  A 33-year-old woman presented to an endocrinology clinic with a 5-year history of secondary amenorrhea. 2 years before presentation, she had noticed progressively worsening signs of virilization.
  
  
  METHODS
  Measurement of levels of serum free and total testosterone, androstenedione, dehydroepiandrosterone sulfate and gonadotropins; transvaginal ultrasonography, abdominal and pelvic MRI and (18)F-fluorodeoxyglucose PET imaging.
  
  
  METHODS
  Virilization secondary to an ovarian Leydig cell tumor.
  
  
  RESULTS
  The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. Complete normalization of androgens and gonadotropin levels was achieved after surgery.
authors.affiliation: Department of Endocrinology, University of São Paulo Medical School, Cerqueira César 05403-000, São Paulo, Brazil. andremfaria@ hotmail.com
authors.forename: André M
authors.initials: AM
authors.lastname: Faria
authors.forename: Ricardo V
authors.initials: RV
authors.lastname: Perez
authors.forename: José A M
authors.initials: JA
authors.lastname: Marcondes
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Freire
authors.forename: Roberto
authors.initials: R
authors.lastname: Blasbalg
authors.forename: José
authors.initials: J
authors.lastname: Soares
authors.forename: Kleber
authors.initials: K
authors.lastname: Simões
authors.forename: Sylvia A Y
authors.initials: SA
authors.lastname: Hayashida
authors.forename: Maria A A
authors.initials: MA
authors.lastname: Pereira
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007984:Leydig Cell Tumor / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D017697:Premenopause / Q000097:blood; D014770:Virilism / Q000097:blood / Q000175:diagnosis* / Q000601:surgery