title: [Severe and acute pancreatitis admitted in intensive care: a prospective epidemiological multiple centre study using CClin network database].
abstract: OBJECTIVE
  To describe the demographic characteristics, incidence of extra-abdominal hospital-acquired infections and outcome of patients admitted to intensive care unit (ICU) with severe acute pancreatitis.
  
  
  METHODS
  A retrospective, observational multiple center (65 centers) analysis of prospectively acquired data.
  
  
  METHODS
  During 2 years, all consecutive admitted patients to ICU for severe acute pancreatitis in the centers participating in the nosocomial infections surveillance network CClin Sud-Est were included. Patients whose ICU stay was less than 48 hours were not included. Demographic characteristics, extra-abdominal hospital-acquired infections and clinical course were described.
  
  
  RESULTS
  During the study period, 510 patients were included which represented 2 % of patients with a length of stay longer than 48 hours in the 65 participating ICUs. The global attack rate of extra-abdominal hospital-acquired infections (pneumonia, bacteremia, urinary tract or central venous catheter infection) was 23 % in overall patients and it was 33 % in the 294 mechanically ventilated patients. ICU mortality was 20 % in overall patients and it was 34 % in mechanically ventilated patients.
  
  
  CONCLUSIONS
  Severe acute pancreatitis represents 2 % of ICU stay longer than 48 hours. Its clinical course is frequently complicated by hospital-acquired infections and is associated with an high ICU mortality rate. This epidemiological observational study may be used for calculating sample size for future multicenter interventional therapeutic studies.
authors.affiliation: Département d'anesthésie-réanimation Saint-Éloi, CHU de Montpellier, 80 avenue Augustin-Fliche, Montpellier, France.
authors.forename: B
authors.initials: B
authors.lastname: Jung
authors.forename: J
authors.initials: J
authors.lastname: Carr
authors.forename: G
authors.initials: G
authors.lastname: Chanques
authors.forename: M
authors.initials: M
authors.lastname: Cisse
authors.forename: P-F
authors.initials: PF
authors.lastname: Perrigault
authors.forename: A
authors.initials: A
authors.lastname: Savey
authors.forename: J-Y
authors.initials: JY
authors.lastname: Lefrant
authors.forename: A
authors.initials: A
authors.lastname: Lepape
authors.forename: S
authors.initials: S
authors.lastname: Jaber
mesh_terms: D000208:Acute Disease; D000368:Aged; D003422:Critical Care; D003428:Cross Infection / Q000453:epidemiology; D016208:Databases, Factual; D005260:Female; D005602:France / Q000453:epidemiology; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012121:Respiration, Artificial; D012151:Resuscitation; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome