title: Onset of adult-onset Still's disease following influenza vaccination.
abstract: We describe that case of a 61-year-old woman who developed high spiking fever, sore throat, polyarthralgia, and salmon pink evanescent rash following influenza vaccination. A diagnosis of adult-onset Still's disease (AOSD) was made based on clinical and laboratory findings. Methylprednisolone pulse therapy followed by oral prednisolone resulted in a favorable outcome. This is the second published case in which a causal relationship between vaccination and onset of AOSD is suggested. Bystander activation would appear to play an important role in inducing the immune reaction.
authors.affiliation: Department of Internal Medicine, Osaka City Sumiyoshi Hospital, 1-2-16 Higashikagaya, Suminoe-ku, Osaka, Osaka, 559-0012, Japan. kmyoshi@rr.iij4u.or.jp
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Hiroko
authors.initials: H
authors.lastname: Oba
authors.forename: Mieko
authors.initials: M
authors.lastname: Minami
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Aoki
mesh_terms: D018771:Arthralgia / Q000188:drug therapy / Q000209:etiology; D005076:Exanthema / Q000188:drug therapy / Q000209:etiology; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects*; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D010612:Pharyngitis / Q000188:drug therapy / Q000209:etiology; D011239:Prednisolone / Q000008:administration & dosage; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D014611:Vaccination / Q000009:adverse effects
chemical_list: D005938:Glucocorticoids; D007252:Influenza Vaccines; D011239:Prednisolone; D008775:Methylprednisolone