title: Lipocalin-1: a potential marker for noninvasive aneuploidy screening.
abstract: This study has identified the first protein, lipocalin-1, in the secretome of human blastocysts that is associated with chromosome aneuploidy. The development of a noninvasive technique to determine an embryo's developmental competence, including chromosomal constitution, by analysis of spent IVF culture medium will be a powerful tool for embryo selection in assisted reproductive technologies.
authors.affiliation: National Foundation for Fertility Research, Lone Tree, Colorado, USA.
authors.forename: Susanna
authors.initials: S
authors.lastname: McReynolds
authors.forename: Lauren
authors.initials: L
authors.lastname: Vanderlinden
authors.forename: John
authors.initials: J
authors.lastname: Stevens
authors.forename: Kirk
authors.initials: K
authors.lastname: Hansen
authors.forename: William B
authors.initials: WB
authors.lastname: Schoolcraft
authors.forename: Mandy G
authors.initials: MG
authors.lastname: Katz-Jaffe
mesh_terms: D000782:Aneuploidy; D015415:Biomarkers / Q000378:metabolism; D001755:Blastocyst / Q000378:metabolism* / Q000473:pathology; D002853:Chromatography, Liquid; D003470:Culture Media / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D046149:Embryo Culture Techniques; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D054835:Lipocalin 1 / Q000378:metabolism*; D011237:Predictive Value of Tests; D011296:Prenatal Diagnosis / Q000379:methods; D040901:Proteomics / Q000379:methods; D053719:Tandem Mass Spectrometry; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D003470:Culture Media; C518443:LCN1 protein, human; D054835:Lipocalin 1