title: Atherogenic lipid profile and systolic blood pressure are associated with carotid artery intima-media thickness in children with Turner syndrome.
abstract: OBJECTIVE
  Women with Turner syndrome (TS) have greater carotid artery intima-media thickness (cIMT) known to be a risk factor for atherosclerosis in adults. To determine whether there are risk factors for atherosclerosis in children with TS, we compared cIMT, anthropometric and metabolic parameters between children with TS and healthy controls.
  
  
  METHODS
  Data of children with TS with XO karyotype (n=24, mean age: 11.6±3.6) were compared with those of healthy children (n=24, mean age: 10.5±3.6) with respect to anthropometric parameters, lipid levels, insulin resistance and cIMT which was measured by high resolution B-mode ultrasonography.
  
  
  RESULTS
  Mean age and cIMT values were similar in the two groups of children. However in children with TS, fasting glucose (p=0.01), total cholesterol (p=0.006), triglyceride (p=0.04) levels and HDL-cholesterol (p=0.002) levels were higher than those of controls. In the TS group, cIMT correlated positively with LDL-cholesterol (r=0.435, p=0.034) and with systolic blood pressure (r=0.430, p=0.036) and negatively with HDL-cholesterol (r=-0.518, p=0.01). In stepwise regression analysis, HDL-cholesterol emerged as a significant predictor of cIMT (b= -0.518, p=0.01) contributing to 26.8 % of its variability.
  
  
  CONCLUSIONS
  The systolic blood pressure and dyslipidaemia were shown to be risk factors for atherosclerosis in children with TS.
authors.affiliation: Department of Pediatric Endocrinology, GATA Medical Faculty, İstanbul, Turkey. pirgon@mynet.com
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Pirgon
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Atabek
authors.forename: Bülent
authors.initials: B
authors.lastname: Oran
authors.forename: Rıdvan
authors.initials: R
authors.lastname: Güçlü
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology* / Q000473:pathology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D012307:Risk Factors; D014424:Turner Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol