title: Development of Cushing's syndrome during effective chemotherapy for small cell lung cancer.
abstract: Paraneoplastic Cushing's syndrome caused by ectopic adrenocorticotropin (ACTH) production has been reported. However, most cases of this syndrome are diagnosed before first-line chemotherapy or at the time of disease recurrence. Here, we present a 53-year-old man who gradually developed the symptoms of Cushing's syndrome during effective chemotherapy for small cell lung cancer. His symptoms were controlled using mitotane, but his primary cancer progressed and he died 5 months after the start of chemotherapy. This very rare case of Cushing's syndrome associated with small cell lung cancer during effective chemotherapy is presented here.
authors.affiliation: Thoracic Oncology Division, National Cancer Center Hospital East, Japan. ksuyama@east.ncc.go.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Suyama
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Naito
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Yoh
authors.forename: Seiji
authors.initials: S
authors.lastname: Niho
authors.forename: Koichi
authors.initials: K
authors.lastname: Goto
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ohmatsu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishiwaki
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ohe
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000971:Antineoplastic Combined Chemotherapy Protocols; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000188:drug therapy*; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology*
chemical_list: D000324:Adrenocorticotropic Hormone