title: SirT1 brings stemness closer to cancer and aging.
abstract: Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy.
authors.affiliation: Department of Immunology and Oncology, Centro Nacional Biotecnología/CSIC, Cantoblanco, Madrid, Spain.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Calvanese
authors.forename: Mario F
authors.initials: MF
authors.lastname: Fraga
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D056564:Sirtuin 1 / Q000378:metabolism*; D013234:Stem Cells / Q000502:physiology
chemical_list: D056564:Sirtuin 1