title: A transmembrane inner nuclear membrane protein in the mitotic spindle.
abstract: We have recently characterized a novel transmembrane protein of the inner nuclear membrane of mammalian cells. The protein has two very interesting features. First, despite being an integral membrane protein it is able to concentrate in the membranes colocalizing with the mitotic spindle in metaphase and anaphase. Hence, the protein was named Samp1, Spindle associated membrane protein 1. Secondly, it displays a functional connection to centrosomes. This article discusses various aspects of Samp1 in relation to possible cellular function(s).
authors.affiliation: Life Sciences; Södertörns University; Huddinge, Sweden.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Figueroa
authors.forename: Santhosh
authors.initials: S
authors.lastname: Gudise
authors.forename: Veronica
authors.initials: V
authors.lastname: Larsson
authors.forename: Einar
authors.initials: E
authors.lastname: Hallberg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D045584:Chromosome Positioning; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009685:Nuclear Envelope / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins