title: Automated preparation of Re-188 lipiodol for the treatment of hepatocellular carcinoma.
abstract: The iodinated oil lipiodol is commonly used as a carrier for in situ delivery of drugs or radioactivity to hepatic tumors. Recently, we reported a new kit formulation for high-activity labeling of lipiodol with the β-emitting radionuclide Re-188. Since the whole preparation involves different steps and complex manipulations of high-activity samples, we describe here an automated synthesis module that allows the easy preparation of sterile and pyrogen-free samples of Re-188 lipiodol ready to be administered to the patient. Important advantages include the possibility to incorporate high Re-188 activity into the lipiodol hydrophobic phase and a sharp reduction of radiation exposure of the operator assisting the labelling procedure. Application of this modular reaction system could be also extended to the preparation of other Re-188 radiopharmaceuticals and to compound labelled with different β-emitting therapeutic radionuclides.
authors.affiliation: Laboratory of Nuclear Medicine, Department of Radiological Sciences, University of Ferrara, 44121 Ferrara, Italy.
authors.forename: Licia
authors.initials: L
authors.lastname: Uccelli
authors.forename: Micol
authors.initials: M
authors.lastname: Pasquali
authors.forename: Alessandra
authors.initials: A
authors.lastname: Boschi
authors.forename: Melchiore
authors.initials: M
authors.lastname: Giganti
authors.forename: Adriano
authors.initials: A
authors.lastname: Duatti
mesh_terms: D000818:Animals; D001331:Automation; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy*; D005260:Female; D008113:Liver Neoplasms / Q000532:radiotherapy*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C497093:(188)Re-lipiodol; D009942:Organometallic Compounds