title: Favorable outcome in traumatic brain injury patients with impaired cerebral pressure autoregulation when treated at low cerebral perfusion pressure levels.
abstract: BACKGROUND
  Cerebral pressure autoregulation (CPA) is defined as the ability of the brain vasculature to maintain a constant blood flow over a range of different systemic blood pressures by means of contraction and dilatation.
  
  
  OBJECTIVE
  To study CPA in relation to physiological parameters, treatment, and outcome in a series of traumatic brain injury patients.
  
  
  METHODS
  In this prospective observational study, 44 male and 14 female patients (age, 15-72 years; mean, 38.7 years; Glasgow Coma Scale score, 4-13; median, 7) were analyzed. Patients were divided into groups on the basis of status of CPA (more pressure active vs more pressure passive) and level of cerebral perfusion pressure (CPP; low vs high CPP). The proportions of favorable outcome in the groups were assessed. Differences in physiological variables in the different groups were analyzed.
  
  
  RESULTS
  Patients with more impaired CPA treated at CPP levels below median had a significantly higher proportion of favorable outcome compared with patients with more impaired CPA treated at CPP levels above median. No significant difference in outcome was seen between patients with more intact CPA when divided by level of CPP. In patients with more impaired CPA, CPP<50 mm Hg and CPP<60 mm Hg were associated with favorable outcome, whereas CPP>70 mm Hg and CPP>80 mm Hg were associated with unfavorable outcome. In patients with more intact CPA, no difference in physiological variables was seen between patients with favorable and unfavorable outcomes.
  
  
  CONCLUSIONS
  Our results support that in traumatic brain injury patients with impaired CPA, CPP should not be elevated.
authors.affiliation: Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden. ulf.johnson@neuro.uu.se
authors.forename: Ulf
authors.initials: U
authors.lastname: Johnson
authors.forename: Pelle
authors.initials: P
authors.lastname: Nilsson
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ronne-Engström
authors.forename: Tim
authors.initials: T
authors.lastname: Howells
authors.forename: Per
authors.initials: P
authors.lastname: Enblad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006487:Hemostasis; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D015424:Reperfusion / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult