title: Nuclear receptors in liver disease.
abstract: Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as well as liver regeneration, inflammation, fibrosis, cell differentiation, and tumor formation. Derangements of nuclear receptor regulation and genetic variants may contribute to the pathogenesis and progression of liver diseases. This places nuclear receptors into the frontline for novel therapeutic approaches for a broad range of hepatic disorders and diseases including cholestatic and fatty liver disease, drug hepatotoxicity, viral hepatitis, liver fibrosis, and cancer.
authors.affiliation: Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Wagner
authors.forename: Gernot
authors.initials: G
authors.lastname: Zollner
authors.forename: Michael
authors.initials: M
authors.lastname: Trauner
mesh_terms: D001647:Bile Acids and Salts / Q000502:physiology; D006528:Carcinoma, Hepatocellular / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D002779:Cholestasis / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D006505:Hepatitis / Q000503:physiopathology; D006509:Hepatitis B / Q000503:physiopathology; D006526:Hepatitis C / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000503:physiopathology; D008107:Liver Diseases / Q000503:physiopathology*; D008115:Liver Regeneration / Q000502:physiology; D065626:Non-alcoholic Fatty Liver Disease; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology* / Q000627:therapeutic use; D014158:Transcription, Genetic / Q000502:physiology; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D008076:Cholesterol, HDL; D018160:Receptors, Cytoplasmic and Nuclear; D014280:Triglycerides; D005947:Glucose