title: Efficient computational methods for strongly coupled cardiac electromechanics.
abstract: Strongly coupled cardiac electromechanical models can further our understanding of the relative importance of feedback mechanisms in the heart, but computational challenges currently remain a major obstacle, which limit their widespread use. To address this issue, we present a set of efficient computational methods including an efficient adaptive cell model integration scheme and a solution method for the monodomain equations that maintains high conduction velocity for time steps greater than 0.1 ms. We also present a novel method for increasing the efficiency of simulating electromechanical coupling, which shows a significant reduction in computational cost of the mechanical component on a personalized left ventricular geometry with an active contraction cell model reparametrized for human cells.
authors.affiliation: Computing Laboratory, University of Oxford, Oxford, UK. sander.land@gmail.com
authors.forename: Sander
authors.initials: S
authors.lastname: Land
authors.forename: Steven A
authors.initials: SA
authors.lastname: Niederer
authors.forename: Nicolas P
authors.initials: NP
authors.lastname: Smith
mesh_terms: D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology