title: [Monitoring of the renal function changes during chemotherapy based on high-dose cisplatin in patients with lung cancer].
abstract: BACKGROUND
  To study the methods for monitoring nephrotoxicity of cisplatin in lung cancer chemotherapy.
  
  
  METHODS
  The serum urea nitrogen (BUN), creatine (Cr) and urine β2-microglobulin ( β2-MG),α1-microglobulin(α1-MG), albumin (Alb), transferrin (TRF), and retinol-binding-protein (RBP) were measured dynamically in 61 patients with lung cancer who received high-dose chemotherapy with DDP (80- 120 mg/m2) (totally 114 cycles), and some indexes of early nephrotxcity were screened.
  
  
  RESULTS
  At the early stage of chemotherapy (d1-5), the abnormal rates of urine β2-MG and α1-MG were much more predominant than those of other indexes (P < 0.001). The abnormal rates of serum BUN and Cr were increased significantly in the late period of chemotherapy (d10). There were abnormal elevation of urine β2-MG and/or α1-MG at the early stage of chemotherapy for the patients whose serum BUN and creatine were all abnormal at the late stage.
  
  
  CONCLUSIONS
  The urine β2-MG and /or α1-MG might be the valuable indexes for early diagnosis of nephrotoxicity in lung cancer chemotherapy with cisplatin.
authors.affiliation: The Medical Oncology, Cancer Center, The West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China.
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
authors.forename: Mei
authors.initials: M
authors.lastname: Hou
authors.forename: Meng
authors.initials: M
authors.lastname: Qiu
authors.forename: Jianping
authors.initials: J
authors.lastname: He
authors.forename: Hui
authors.initials: H
authors.lastname: Chen