title: [Study on the relationship between the dendritic cell infiltration in cancer tissues and prognosis in patients with lung cancer].
abstract: BACKGROUND
  To study the correlation among the number of tumor-infiltrating dendritic cells (TIDC) in cancer tissues and biological behavior and prognosis in lung cancer patients.
  
  
  METHODS
  S-100 protein expression level was determined in 39 patients with lung cancer by immunohistochemistry technique. The number of S-100 + TIDC and DNA ploidy were measured by means of flow cytometry.
  
  
  RESULTS
  The rate of positive S-100 protein expression was 100% in 39 patients, S-100 + cells showed typical morphology of dendritic cells. The percentage of S-100 +TIDC in patients with heteroploid (21.81%±8.18%) was significantly higher than those with diploid (16.03%±4.75%) (P=0.006). There was no statistical difference between lymph node metastasis group (20.43%±7.74%) and no lymph node metastasis group ( 19.41% ±7.76%), between tumor size greater than 3cm group ( 20.90% ±8.65%) and less than 3cm group ( 19.70% ±7.61%), between non-small cell lung cancer group (19.48%±7.98%) and small cell lung cancer group (21.74%±6.17%). No correlation was found between survival time ( 1 year , 1-3 years, greater than 3 years, respectively) and percentage of S-100 +TIDC (21.96%±8.05%, 19.47%±6.18%, 19.14%±8.76%, respectively).
  
  
  CONCLUSIONS
  The number of TIDC should not be chosen as an independent prognostic criterion in human lung cancer.
authors.affiliation: Department of microbiology and immunology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R.China.
authors.forename: Ruijing
authors.initials: R
authors.lastname: Zhao
authors.forename: Huidong
authors.initials: H
authors.lastname: Feng
authors.forename: Xiurong
authors.initials: X
authors.lastname: Wang
authors.forename: Dailun
authors.initials: D
authors.lastname: Hu
authors.forename: Tienian
authors.initials: T
authors.lastname: Zhu