title: [Effects of taurine on hemorheology of rats with type 2 diabetes].
abstract: OBJECTIVE
  To observe the effects of taurine on hemorheology and oxidative stress of diabetic rats.
  
  
  METHODS
  40 rats were divided into control group, diabetes group and treatment group at random. Diabetic model was reproduced by intraperitoneal injection of streptozotocin. After having been treated with taurine for 8 weeks, glycosylated hemoglobin (HbA1c) and the serum contents of glucose, superoxide dismutase(SOD), malondialdehyde (MDA) were measured. The changes of hemorheology in different groups were detected respectively.
  
  
  RESULTS
  Compared with control group, the content of glucose, MDA and HbA1c in diabetic rats was increased, the activity of SOD was decreased, the levels of whole blood viscosity and the aggregation index of red blood cells and hematocrit were increased and RBC deformability index was decreased in diabetic rats. Moreover, taurine was able to apparently reduce high blood glucose and HbA1c (P < 0.05), markedly elevated the activity of SOD, lowered the content of MDA (P < 0.01); and taurine also could significantly reduce the levels of whole blood viscosity and the aggregation index of red blood cells and hematocrit in the meanwhile, and increase RBC deformability index (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  Taurine could enhance the ability of oxidation resistance, improve blood rheology property in diabetic rats, at the same time it could be beneficial to prevent and cure the development of diabetic blood vessel complication.
authors.affiliation: Department of Pathophysiology, North China Coal Medical College, Tangshan 063000, China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Zhang
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Zhang
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Men
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhao
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Kong
authors.forename: Shun-Yun
authors.initials: SY
authors.lastname: Dong
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004907:Erythrocyte Deformability; D006442:Glycated Hemoglobin / Q000378:metabolism; D018056:Hemorheology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D013654:Taurine