title: One-pot strategies for the synthesis of the tetrasaccharide linkage region of proteoglycans.
abstract: A linker-attached tetrasaccharide corresponding to the linkage region of proteoglycans was synthesized via one-pot procedures from the silylated monosaccharide derivatives. Regioselective one-pot protection protocols were applied in generating the requisite monosaccharide building blocks whereas stereoselective one-pot glycosylation approaches were utilized to assemble the tetrasaccharide skeleton.
authors.affiliation: Genomics Research Center, Academia Sinica, 128 Sec.2 Academia Road, Taipei 115, Taiwan.
authors.forename: Teng-Yi
authors.initials: TY
authors.lastname: Huang
authors.forename: Medel Manuel L
authors.initials: MM
authors.lastname: Zulueta
authors.forename: Shang-Cheng
authors.initials: SC
authors.lastname: Hung
mesh_terms: D006031:Glycosylation; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D011509:Proteoglycans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D009844:Oligosaccharides; D011509:Proteoglycans