title: Depression subtypes and 5-years risk of mortality in aged 70 years: a population-based cohort study.
abstract: OBJECTIVE
  To estimate the mortality risk related to different mood disorders in a geriatric sample of subjects aged 70 years and over without dementia.
  
  
  METHODS
  All non-demented subjects at baseline who participate on a second phase of a population-based cohort study were included. Adjusted Cox proportional hazards models were used to determine the association between depression and 5-year survival of 451 elderly people without dementia originally recruited for a representative community dementia cohort study. Baseline evaluation included the Cambridge Mental Disorders of the Elderly Examination Schedule. Depressive disorders (major and minor episode) were assessed according DSM-IV criteria and classified according the age of onset (late vs. early). The late-onset depression was classified according to the presence or absence of depression-executive dysfunction syndrome (DEDS).
  
  
  RESULTS
  The initial cohort size was 451 subjects, among which 10.9% (n = 49) suffered a major depressive episode and 10.4% (n = 47) a minor depressive disorder. Among the total affective disorders, 77.9% (n = 74) were late-onset depressions and 29.5% (n = 28) had executive dysfunction. After 5 years, the vital status of 94% (n = 424) of the participants was known and the mortality was 18.9% (n = 80). Late-onset major depressive episode with executive dysfunction was related to mortality after adjustment by age, gender, marital status, level of education, comorbidity (or health global status) and cognitive impairment (HR = 3.70; 95% CI = 1.55-8.83). The executive dysfunction was found to be an independent mortality risk factor (HR = 2.05; 95% CI = 1.15-3.64).
  
  
  CONCLUSIONS
  There is a statistically significant association between mortality and late-onset major depression with executive dysfunction.
authors.affiliation: Research Unit, Institut d'Assistència Sanitària, Salt, Girona, Spain. uvamid@ias.scs.es
authors.forename: Joan
authors.initials: J
authors.lastname: Vilalta-Franch
authors.forename: Xènia
authors.initials: X
authors.lastname: Planas-Pujol
authors.forename: Secundino
authors.initials: S
authors.lastname: López-Pousa
authors.forename: Jordi
authors.initials: J
authors.lastname: Llinàs-Reglà
authors.forename: Javier
authors.initials: J
authors.lastname: Merino-Aguado
authors.forename: Josep
authors.initials: J
authors.lastname: Garre-Olmo
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003863:Depression / Q000401:mortality*; D003866:Depressive Disorder / Q000401:mortality*; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis