title: Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2, but not in type 1, diabetes.
abstract: BACKGROUND
  As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN.
  
  
  METHODS
  A total of 15 T1D and 48 T2D patients with HbA(1c) greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6 months after insulin treatment.
  
  
  RESULTS
  While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study.
  
  
  CONCLUSIONS
  Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.
authors.affiliation: Service de Diabétologie, Endocrinologie et Nutrition, Hôpital Bichat, Assistance publique des Hôpitaux de Paris, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
authors.forename: C
authors.initials: C
authors.lastname: Abi Khalil
authors.forename: K
authors.initials: K
authors.lastname: Mohammedi
authors.forename: R
authors.initials: R
authors.lastname: Aubert
authors.forename: F
authors.initials: F
authors.lastname: Travert
authors.forename: S
authors.initials: S
authors.lastname: Hadjadj
authors.forename: R
authors.initials: R
authors.lastname: Roussel
authors.forename: F
authors.initials: F
authors.lastname: Fumeron
authors.forename: M
authors.initials: M
authors.lastname: Marre
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020033:Protein Isoforms
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D020033:Protein Isoforms; C517652:hemoglobin A1c protein, human