title: [Immunomodulatory role of perfluorane in the preoperative preparation of patients with rhegmatogenous retinal detachment].
abstract: The paper presents the results of studying the effect of 10% perfluorane (PF) emulsion intravenously injected 1-2 days before surgical treatment for rhegmatogenous retinal detachment on the levels of the cytokines IL-1beta, TNF-alpha, IL-6, and IL-4 in the serum and subretinal fluid of patients. PF infusion was found to exert an immunomodulatory effect that favored a short-term increase in the serum level of proinflammatory cytokines (IL- 1beta and IL-6) at week 1 and TNF-alpha on day 1) with their gradual normalization. The subretinal fluid showed recovery of the mechanisms for local immunological reactions; eye inflammation reduced due to the decreased production of proinflammatory cytokines and simultaneously the elevated level of the anti-inflammatory cytokine IL-4.
authors.forename: M M
authors.initials: MM
authors.lastname: Bikbov
authors.forename: V K
authors.initials: VK
authors.lastname: Surkova
authors.forename: N E
authors.initials: NE
authors.lastname: Shevchuk
authors.forename: O V
authors.initials: OV
authors.lastname: Chaĭka
mesh_terms: D000328:Adult; D001802:Blood Substitutes / Q000008:administration & dosage; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D012163:Retinal Detachment / Q000276:immunology* / Q000378:metabolism / Q000601:surgery; D058471:Subretinal Fluid / Q000378:metabolism
chemical_list: D001802:Blood Substitutes; D016207:Cytokines; D005466:Fluorocarbons; C063334:perftoran