title: Inflammatory and neuroendocrine biomarkers of prognosis after ischemic stroke.
abstract: Stroke is the third leading cause of mortality in the USA and one of the leading causes of severe morbidity. It is important to provide stroke patients and physicians with the most accurate prognostic information to optimize care and allocation of healthcare resources. Reliable prognostic markers available during the initial phase after acute stroke may aid clinical decision-making. Several interesting candidate biomarkers have been studied to address prognostic questions; this article will focus on selected inflammatory and neuroendocrine markers. The utility of a biomarker is defined by its ability to improve clinical decision-making and add timely information beyond that readily available from clinical examination and routine imaging. This aim has not been completely achieved yet for any biomarkers, but promising data are available and further studies are ongoing.
authors.affiliation: Stroke Division, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. mk3270@columbia.edu
authors.forename: Mira
authors.initials: M
authors.lastname: Katan
authors.forename: Mitchell S V
authors.initials: MS
authors.lastname: Elkind
mesh_terms: D015415:Biomarkers; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000378:metabolism*; D011379:Prognosis; D020521:Stroke / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers