title: [Preparation of nasal thermosensible gels of Chinese medicine Xingbi and release behavior in vitro].
abstract: OBJECTIVE
  To prepare the nasal thermosensible gels of Chinese medicine Xingbi and study the release mechanism.
  
  
  METHODS
  The gels were prepared by using P407 as the gel matrix and P188 and PEG 6000 were used to adjust the gelatination temperature. The formulations were screened by the method of orthogonal test. Mathematic models were used to imitate the drug release.
  
  
  RESULTS
  20% poloxmar 407, 2% poloxmar 188 and 2% PEG 6000 were suitable to Chinese medicine Xingbi thermosensitive gel in situ. Nasal thermosensible gels of Chinese medicine Xingbi was gelated at the temperature between 32-34 degrees C and the dissolution curves in vitro showed that the drug release could be best described by the Higuchi equation.
  
  
  CONCLUSIONS
  The formulation of the nasal thermosensible gels of Chinese medicine Xingbi is reasonable and it is worth doing further research.
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China. chukd5917@163.com
authors.forename: Kedan
authors.initials: K
authors.lastname: Chu
authors.forename: Huang
authors.initials: H
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Weirong
authors.initials: W
authors.lastname: Xie
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics*; D005782:Gels / Q000737:chemistry; D006801:Humans; D009668:Nose Diseases / Q000188:drug therapy; D013696:Temperature
chemical_list: D004365:Drugs, Chinese Herbal; D005782:Gels; C000613610:xingbi