title: Recombination between genes coding for immune response and the serologically determined antigens in the chickenB system.
abstract: Evidence is presented for a crossover between the genes coding for the serologically determined (SD) antigens on erythrocytes and an immune response gene (Ir-GAT) controlling immune response to the synthetic polypeptide GAT within theB complex, the MHC of chickens. TheIr-GAT (1) andIr-GAT (19) alleles control low and high immune response to GAT, respectively. Both low and high responders were recovered as recombinants fromB (1) B (1) andB (19) B (19) birds. The low-responder haplotypes are homozygous for theIr-GAT (1) allele and the high-responder haplotypes carry theIr-GAT (19) allele. Mortality forB (1) B (1) nonresponder birds was 39%, compared with 19% for theB (1) B (1) high responders; this suggests the possibility that genes located within the immune response region of theB complex exert some genetic control over viability and survival.
authors.affiliation: Department of Animal Science, Iowa State University, 50011, Ames, Iowa.
authors.forename: I Y
authors.initials: IY
authors.lastname: Pevzner
authors.forename: C L
authors.initials: CL
authors.lastname: Trowbridge
authors.forename: A W
authors.initials: AW
authors.lastname: Nordskog