title: IFN-λs and BDCA3+/CD8α+ dendritic cells: towards the design of novel vaccine adjuvants?
abstract: IFN-λs are related to type I interferons but their receptor has a more cell-restricted pattern of expression. Consequently, one can expect that IFN-λs have antiviral and anti-tumoral activities as well as immunomodulatory properties with less adverse side-effects than type I interferons. However, their roles in physiopathology and immunoregulation remain to be fully elucidated. The study under evaluation identifies that murine CD8α(+) dendritic cells and their recently described human equivalent, BDCA3(+) dendritic cells, are the major producers of IFN-λs in response to dsRNA poly I:C. This study illustrates a new function for a DC subset conserved between species. These findings may impact the development of vaccine or therapeutic strategies based on DC targeting.
authors.affiliation: INSERM, UMR 634, Faculté de Médecine Pasteur, 28 Avenue de Valombrose, 06107 Nice cedex 2, France.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Luci
authors.forename: Fabienne
authors.initials: F
authors.lastname: Anjuère