title: A convergent synthesis of the C1-C16 segment of goniodomin A via palladium-catalyzed organostannane-thioester coupling.
abstract: A convergent synthesis of the C1-C16 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved via a 2-fold application of palladium-catalyzed organostannane-thioester coupling.
authors.affiliation: Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, Aoba-ku, Sendai, Japan. hfuwa@bios.tohoku.ac.jp
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fuwa
authors.forename: Motohiro
authors.initials: M
authors.lastname: Nakajima
authors.forename: Jinglu
authors.initials: J
authors.lastname: Shi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Takeda
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Saito
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000199:Actins / Q000378:metabolism; D002384:Catalysis; D004952:Esters; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009947:Organotin Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000199:Actins; D004952:Esters; D004987:Ethers; D018942:Macrolides; D009947:Organotin Compounds; C059668:goniodomin A; D010165:Palladium