title: Synaptotagmin 4: a new antiobesity target?
abstract: In this issue of Neuron, Zhang et al. show that Synaptotagmin 4 (Syt4) is specifically induced in adult hypothalamic oxytocin neurons by high-fat diet. Evidence is provided to support a critical role for Syt4 in negative regulation of oxytocin release, which in turn is responsible for diet-induced obesity, raising the possibility of using Syt4 as a new antiobesity target.
authors.affiliation: Center for Diabetes and Obesity Research of the Brown Foundation Institute of Molecule Medicine and Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. qingchun.tong@uth.tmc.edu
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Tong