title: Local heat application to the leg reduces muscle sympathetic nerve activity in human.
abstract: The study was designed to assess the effects of local heat (LH) application on postganglionic muscle sympathetic nerve activity (MSNA) measured by microneurography in healthy men. In the first protocol, MSNA of the left peroneal nerve, blood pressure (BP), heart rate (HR), and skin temperature of the shin (TSK) were recorded in nine men. In the second protocol, leg blood flow (LBF) was measured in the same subjects by strain-gauge plethysmography. In both protocols, after 10 min of rest in the supine position, a heated hydrocollator pack was applied to the shin and anterior foot for 15 min and recovery was monitored over a period of 20 min. TSK gradually increased from 31.7 ± 0.1 to 41.9 ± 0.5°C (mean ± SEM) during LH. No subject complained of pain, and BP and HR remained constant. The MSNA burst rate (16.1 ± 2.1 beats/min) during the control period decreased significantly (P < 0.05) to 72.0 ± 2.3% during LH. Total MSNA also decreased to 59.2 ± 2.6% (P < 0.05) during LH, but both immediately returned to baseline at recovery. In contrast, LBF in the left leg significantly and immediately increased (P < 0.05) after LH application and remained significantly elevated until the end of the recovery period. These results suggest that: (1) LH application significantly attenuates MSNA without any changes in HR and BP. (2) Other factors in addition to MSNA seem to control regional blood flow in the lower extremity during LH.
authors.affiliation: Division of Comprehensive Medicine, Department of Rehabilitation Medicine, Osaka Medical College, Osaka 569-8686, Japan.
authors.forename: Noriyo
authors.initials: N
authors.lastname: Takahashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Nami
authors.initials: N
authors.lastname: Kanno
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kimura
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Toge
authors.forename: Kyu-Ha
authors.initials: KH
authors.lastname: Lee
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Tajima
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D007866:Leg / Q000098:blood supply / Q000502:physiology; D008297:Male; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000294:innervation* / Q000502:physiology; D010543:Peroneal Nerve / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D012881:Skin Temperature / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000502:physiology*; D055815:Young Adult