title: Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women: the ROAD study.
abstract: OBJECTIVE
  To clarify the association of knee osteoarthritis (KOA) with overweight (OW), hypertension (HTN), dyslipidemia (DL), and impaired glucose tolerance (IGT), which are components of metabolic syndrome (MS), in a Japanese population.
  
  
  METHODS
  We enrolled 1690 participants (596 men, 1094 women) from the large-scale cohort study Research on Osteoarthritis Against Disability (ROAD), begun in 2005 to clarify epidemiologic features of OA in Japan. KOA was evaluated by the Kellgren-Lawrence grade, minimum joint space width (MJSW), minimum joint space area (JSA), and osteophyte area (OPA). OW, HTN, DL, and IGT were assessed using standard criteria.
  
  
  RESULTS
  The prevalence of KOA in the total population in the age groups ≤ 39, 40-49, 50-59, 60-69, 70-79, and ≥ 80 years was 2.2%, 10.7%, 28.2%, 50.8%, 69.0%, and 80.5%, respectively. Logistic regression analyses after adjustment for age, sex, regional difference, smoking habit, alcohol consumption, physical activities, regular exercise, and history of knee injuries revealed that the OR of KOA significantly increased according to the number of MS components present (1 component: OR 1.21, 95% CI 0.88-1.68, p = 0.237; 2 components: OR 1.89, 95% CI 1.33-2.70, p < 0.001; 3 or more components: OR 2.72, 95% CI 1.77-4.18; p < 0.001). The number of MS components was inversely related to medial MSJW (ß = -0.148, R(2) = 0.21, p < 0.001), medial JSA (women only; ß = -0.096, R(2) = 0.18, p = 0.001), and positively related to OPA (ß = 0.12, R(2) = 0.11, p < 0.001).
  
  
  CONCLUSIONS
  The accumulation of MS components is significantly related to presence of KOA. MS prevention may be useful to reduce cardiovascular disease and KOA risk.
authors.affiliation: Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. yoshimuran-ort@h.u-tokyo.ac.jp
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Muraki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Toru
authors.initials: T
authors.lastname: Akune
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D018149:Glucose Intolerance / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007564:Japan / Q000453:epidemiology; D007719:Knee Joint / Q000473:pathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology; D050177:Overweight / Q000150:complications*; D015995:Prevalence; D012307:Risk Factors