title: Peritoneal resorption capacity for lipopolysaccharide and interleukin-6 in acute zymosan-induced chemical peritonitis.
abstract: OBJECTIVE
  To evaluate peritoneal resorption capacity for lipopolysaccharide (LPS) and interleukin-6 (IL-6) in a model of chemical peritonitis.
  
  
  METHODS
  Zymosan peritonitis was induced in anesthetized rats. LPS was injected intraperitoneally to different groups at 4 h (n = 10), 8 h (n = 9), 12 h (n = 9), and 24 h (n = 9) after peritonitis and to a control group (n = 8). Similarly, IL-6 was injected intraperitoneally to different groups at 4 h (n = 9), 8 h (n = 10), 12 h (n = 10), and 24 h (n = 10) after peritonitis, and to a control group (n = 10). Plasma levels of LPS or IL-6 were measured immediately after intraperitoneal injections of LPS or IL-6, respectively, and at 5, 15, 30, 45, and 60 min later.
  
  
  RESULTS
  There was no change over time in plasma LPS levels in the groups receiving LPS intraperitoneally (p = 0.4). There was highly significant change over time in the IL-6 level in the studied time periods in the groups receiving IL-6 intraperitoneally (p < 0.0001). There was an increase in the plasma IL-6 level when sampled at 4 h after peritonitis.
  
  
  CONCLUSIONS
  There was a reduction of resorption capacity of inflamed peritoneum for inflammatory mediators in acute chemical peritonitis.
authors.affiliation: Department of Surgery, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
authors.forename: F C
authors.initials: FC
authors.lastname: Torab
authors.forename: F M
authors.initials: FM
authors.lastname: Abu-Zidan
authors.forename: S
authors.initials: S
authors.lastname: Al-Salam
authors.forename: K R
authors.initials: KR
authors.lastname: Padmanabahn
authors.forename: D
authors.initials: D
authors.lastname: Berger
authors.forename: F J
authors.initials: FJ
authors.lastname: Branicki
mesh_terms: D000818:Animals; D018836:Inflammation Mediators / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D015850:Interleukin-6 / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D010537:Peritoneum / Q000473:pathology / Q000503:physiopathology; D010538:Peritonitis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D015054:Zymosan / Q000633:toxicity
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D008070:Lipopolysaccharides; D015054:Zymosan