title: Monoallelic deletion of NFKBIA in glioblastoma: when less is more.
abstract: Bredel et al. (2010) recently identified a subset of glioblastomas that harbor monoallelic loss of NFKBIA, which negatively affects patient prognosis. This finding raises new questions as to the role of IκBα and NF-κB in glioblastoma, the relationship between EGFR and NF-κB signaling, and potential therapeutic targets.
authors.affiliation: Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Rinkenbaugh
authors.forename: Albert S
authors.initials: AS
authors.lastname: Baldwin