title: The hippocampal learning-behavior translation and the functional significance of hippocampal dysfunction in schizophrenia.
abstract: How is hippocampal learning, including place learning, translated into behavior? The hippocampus integrates, along its septotemporal axis, substrates of rapid place learning, including entorhinal-hippocampal connectivity, with functional connectivity to subcortical sites and prefrontal cortex, which play central roles in behavioral-control functions, including sensorimotor, emotional, motivational, attentional, and executive functions. I present recent evidence that such integration, for which the intermediate hippocampus is a key neuroanatomical substrate, enables translation of rapid place learning into adaptive behavior. What are the clinical implications of the hippocampal learning-behavior translation? Focusing on hippocampal overactivity, which has emerged as a central feature of schizophrenia pathophysiology, I highlight how, due to functional connectivity enabling the learning-behavior translation, hippocampal dysfunction may cause not only memory deficits, but also neural-network disruptions underlying psychosis and attentional and executive deficits.
authors.affiliation: School of Psychology and Institute of Neuroscience, University of Nottingham, Nottingham, UK. tobias.bast@nottingham.ac.uk
authors.forename: Tobias
authors.initials: T
authors.lastname: Bast
mesh_terms: D000818:Animals; D001519:Behavior / Q000502:physiology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000502:physiology / Q000503:physiopathology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*