title: Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures.
abstract: The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth was analyzed by a push out test. Histomorphometry was performed to assess the bone ingrowth depth and bone implant contact. The uncoated and hydroxyapatite-coated cubic structure had significantly higher mechanical strength at the interface compared to the Ti plasma spray coating at 15 weeks of implantation. Bone ingrowth depth was significantly larger for the hydroxyapatite- and brushite-coated structures compared to the uncoated structure. In conclusion, the porous E-beam surface structure showed higher bone ingrowth potential compared to a conventional implant surface after 15 weeks of implantation. Addition of a calcium phosphate coating to the E-beam structure enhanced bone ingrowth significantly. Furthermore, the calcium phosphate coating appears to work as an accelerator for bone ingrowth.
authors.affiliation: Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. L.Biemond@orthop.umcn.nl
authors.forename: J Elizabeth
authors.initials: JE
authors.lastname: Biemond
authors.forename: Tatiane S
authors.initials: TS
authors.lastname: Eufrásio
authors.forename: Gerjon
authors.initials: G
authors.lastname: Hannink
authors.forename: Nico
authors.initials: N
authors.lastname: Verdonschot
authors.forename: Pieter
authors.initials: P
authors.lastname: Buma
mesh_terms: D000497:Alloys; D000818:Animals; D032701:Biomimetics; D001842:Bone and Bones / Q000473:pathology*; D002130:Calcium Phosphates / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D005260:Female; D006041:Goats; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning / Q000379:methods; D013314:Stress, Mechanical; D013499:Surface Properties; D013696:Temperature; D014025:Titanium / Q000737:chemistry
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C031462:titanium alloy (TiAl6V4); D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium