title: Cerebellar brain inhibition is decreased in active and surround muscles at the onset of voluntary movement.
abstract: Highly selective activation of the desired muscles for each movement and inhibition of adjacent muscles is attributed to surround inhibition (SI) which differentially modulates corticospinal excitability in active and surrounding muscles. Cerebellar brain inhibition (CBI) is another inhibitory neuronal network which is known to be active at rest and during tonic muscle contraction. The way in which CBI may be modulated at movement onset and its relationship with SI has not previously been investigated. We assessed motor evoked potential (MEP) size and CBI in first dorsal interosseus (FDI) and abductor digiti minimi (ADM) muscles at rest and during a simple motor task where FDI was an active muscle and ADM was not involved in the movement (surround muscle). At onset of movement, MEP size in ADM was significantly suppressed, confirming the existence of SI. In contrast, CBI in both muscles was found to be significantly decreased at the onset of the movement. This was confirmed even after adjustments for changes in MEP size occurring due to onset of muscle activity in FDI and the effects of SI in ADM. Our findings fail to functionally link SI with CBI, but they do indicate a non-topographically specific modulation of CBI in association with initiation of voluntary movement.
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kassavetis
authors.forename: Britt S
authors.initials: BS
authors.lastname: Hoffland
authors.forename: Tabish A
authors.initials: TA
authors.lastname: Saifee
authors.forename: Kailash P
authors.initials: KP
authors.lastname: Bhatia
authors.forename: Bart P
authors.initials: BP
authors.lastname: van de Warrenburg
authors.forename: John C
authors.initials: JC
authors.lastname: Rothwell
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Edwards
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002531:Cerebellum / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D055815:Young Adult