title: Real-time imaging and detection of intracranial haemorrhage by electrical impedance tomography in a piglet model.
abstract: The aim of this study was to use electrical impedance tomography (EIT) to detect and image acute intracranial haemorrhage (ICH) in an animal model. Blood was infused into the frontal lobe of the brains of anaesthetized piglets and impedance was measured using 16 electrodes placed in a circle on the scalp. The EIT images were constructed using a filtered back-projection algorithm. The mean of all the pixel intensities within a region of interest--the mean resistivity value (MRV)--was used to evaluate the relative impedance changes in the target region. A symmetrical index (SI), reflecting the relative impedance on both sides of the brain, was also calculated. Changes in MRV and SI were associated with the injection of blood, demonstrating that EIT can successfully detect ICH in this animal model. The unique features of EIT may be beneficial for diagnosing ICH early in patients after cranial surgery, thereby reducing the risk of complications and mortality.
authors.affiliation: Department of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: X T
authors.initials: XT
authors.lastname: Shi
authors.forename: F S
authors.initials: FS
authors.lastname: You
authors.forename: F
authors.initials: F
authors.lastname: Fu
authors.forename: R G
authors.initials: RG
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Dai
authors.forename: Z W
authors.initials: ZW
authors.lastname: Zhao
authors.forename: G D
authors.initials: GD
authors.lastname: Gao
authors.forename: X Z
authors.initials: XZ
authors.lastname: Dong
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D017097:Electric Impedance; D004566:Electrodes; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging*; D013552:Swine; D014057:Tomography, X-Ray Computed