title: Brain white matter abnormalities in paediatric Gaucher Type I and Type III using diffusion tensor imaging.
abstract: OBJECTIVE
  Biomarkers to monitor neurological dysfunction in Neuronopathic Gaucher disease (NGD) are lacking. Diffusion tensor imaging (DTI) is a technique which allows us to probe the microstructure of the white-matter of the brain, in-vivo. The aim of this study was to investigate the value of DTI to visualise and quantify white matter integrity in children with NGD and Type I Gaucher.
  
  
  METHODS
  DTI was performed and fractional anisotropy (FA), mean diffusivity (MD), axial (λ(axial)) diffusivity and radial (λ(radial)) diffusivity maps calculated. Tract-based spatial statistics (TBSS) was used to perform a voxel-wise statistical analysis of the main white matter structures compared to age-sex matched control groups.
  
  
  METHODS
  The study was performed at Great Ormond Street Children's Hospital NHS Trust
  
  
  METHODS
  Four NGD and three Type I Gaucher paediatric patients were recruited
  
  
  RESULTS
  The findings suggest the presence of microstructural white matter changes in NGD patients primarily in the middle cerebellar peduncles compared to an age-sex matched control group. This finding is relevant to the clinical manifestation of ataxia seen in NGD. Diffuse non-specific changes were seen in the Type I patients, but without a focal point.
  
  
  CONCLUSIONS
  This study is the first to use DTI to examine the Gaucher brain. While the numbers studied are small, the results suggest that DTI may be an attractive surrogate marker of NGD, worthy of further exploration for use in clinical studies.
authors.affiliation: Institute of Child Health, University College London, London, WC1N 1EH, UK. E.Davies@ich.ucl.ac.uk
authors.forename: Elin Haf
authors.initials: EH
authors.lastname: Davies
authors.forename: Kiran K
authors.initials: KK
authors.lastname: Seunarine
authors.forename: Tina
authors.initials: T
authors.lastname: Banks
authors.forename: Chris A
authors.initials: CA
authors.lastname: Clark
authors.forename: Ashok
authors.initials: A
authors.lastname: Vellodi
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D004058:Diffusion; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005776:Gaucher Disease / Q000175:diagnosis* / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010372:Pediatrics / Q000379:methods; D013681:Tegmentum Mesencephali / Q000002:abnormalities / Q000473:pathology