title: Successful steroid treatment of a patient with autosomal dominant polycystic kidney disease complicated by sarcoidosis.
abstract: The patient was a 54-year-old woman with autosomal dominant polycystic kidney disease (ADPKD) who developed complicating systemic sarcoidosis. Hypercalcemia and an abrupt increase in serum creatinine levels were observed during the clinical course. Steroid therapy was initiated and produced a distinct improvement in renal function. A kidney biopsy was not feasible because ADPKD is a contraindication for renal needle biopsy. The clinical findings strongly suggested renal disorder secondary to tubulointerstitial nephritis caused by renal sarcoidosis with complicating hypercalcemia. In addition to controlling hypertension and improving the hypercalcemia and dehydration, steroid therapy also improved the renal function in this patient.
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iwasa
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. arai@nurs.twmu.ac.jp.
authors.forename: Junko
authors.initials: J
authors.lastname: Arai
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Mitobe
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: Department of Medicine IV, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
mesh_terms: D002116:Calcitonin / Q000031:analogs & derivatives / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000188:drug therapy; D007668:Kidney / Q000503:physiopathology; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000188:drug therapy* / Q000209:etiology; D013256:Steroids
chemical_list: D013256:Steroids; D002116:Calcitonin; D011239:Prednisolone; D003404:Creatinine; C012755:elcatonin