title: Brain tumor and Gliadel wafer treatment.
abstract: Glioblastoma is a rapidly progressive and extremely fatal form of brain tumor with poor prognosis. It is the most common type of primary brain tumor. Even with the most aggressive conventional treatment that comprises surgery followed by radiotherapy and chemotherapy, most patients die within a year of diagnosis. Developments in molecular and cell biology have led to better understanding of tumor development, leading to novel treatment strategies including biological therapy and immunotherapy to combat the deadly disease. Targeted drug delivery strategies to circumvent the blood-brain barrier have shown efficiency in clinical trials. Gliadel wafer is a new approach to the treatment of glioblastoma, which involves controlled release delivery of carmustine from biodegradable polymer wafers. It has shown promising results and provides a silver lining for glioblastoma patients.
authors.affiliation: Department of Neurosurgery, Krishna Institute of Medical Sciences, Secunderabad, India.
authors.forename: M
authors.initials: M
authors.lastname: Panigrahi
authors.forename: P K
authors.initials: PK
authors.lastname: Das
authors.forename: P M
authors.initials: PM
authors.lastname: Parikh
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002330:Carmustine / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D006801:Humans
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003692:Delayed-Action Preparations; D002330:Carmustine