title: The medicinal potential of promising marine macrolides with anticancer activity.
abstract: Marine natural products have become a major source of new chemical entities in the discovery of potential anticancer agents that potently suppress various molecular targets. In particular, the marine macrolides, which include an array of novel biomolecules endowed with outstanding cytotoxic and/or antiproliferative activities, are a prominent class of marine natural products that offer continued promise for breakthroughs in anticancer research. Herein we highlight some recent studies of promising marine macrolides, paying particular attention to their discovery, anticancer activities, mechanisms of action, chemical synthesis, and representative analogues.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan 250012, PR China.
authors.forename: Yunkun
authors.initials: Y
authors.lastname: Qi
authors.forename: Shutao
authors.initials: S
authors.lastname: Ma
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry; D054713:Bryostatins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000095702:Polyether Toxins; D000095662:Polyether Polyketides
chemical_list: D000970:Antineoplastic Agents; D054713:Bryostatins; D004988:Ethers, Cyclic; D018942:Macrolides; C117305:laulimalide; C519136:neopeltolide; C083856:spongistatin 1; D000095702:Polyether Toxins; C070519:halichondrin B; D000095662:Polyether Polyketides