title: Concise review: stem cells for the treatment of cerebellar-related disorders.
abstract: Embryonic neural transplants have become clinically relevant over the past 25 years for their possible application in the treatment of cerebellum-related neurodegenerative diseases. While highlighting the important role that fetal neural progenitors have in meeting these challenges, we define rationales for all types of cell therapy involving adult stem cells as well as human embryonic stem cells (hESC) and human induced pluripotent stem (iPS) cells. The recent advances in the field of hESC and iPS cells, including their capacity for differentiation toward regional specific neural lineages, could open a new era of transplantation in cell-based therapy for cerebellar ataxias.
authors.affiliation: Centro Andaluz de Biología Molecular y Medicina Regenerativa, Avda. Americo Vespucio s/n, Parque Científico y Tecnológico Cartuja, Sevilla, Spain. slaven.erceg@cabimer.es
authors.forename: Slaven
authors.initials: S
authors.lastname: Erceg
authors.forename: Victoria
authors.initials: V
authors.lastname: Moreno-Manzano
authors.forename: Marcela
authors.initials: M
authors.lastname: Garita-Hernandez
authors.forename: Miodrag
authors.initials: M
authors.lastname: Stojkovic
authors.forename: Shomi S
authors.initials: SS
authors.lastname: Bhattacharya
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000637:transplantation*; D000818:Animals; D002526:Cerebellar Diseases / Q000628:therapy*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000637:transplantation*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation*; D019636:Neurodegenerative Diseases / Q000628:therapy; D033581:Stem Cell Transplantation