title: The effect of dietary vanadium on cell cycle and apoptosis of liver in broilers.
abstract: The objective of this study was to clarify the effects of dietary vanadium on cell cycle and apoptosis of liver in broilers. Four hundred and twenty one-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet as control diet or the same diet amended to contain 5, 15, 30, 45, and 60 mg/kg vanadium supplied as ammonium metavanadate for 42 days. As tested by flow cytometry, hepatocytes in G                         (0)/G                         (1) phase were significantly increased in number in 45 and 60 mg/kg groups, and hepatocytes in S, G                         (2) + M phases in 45 and 60 mg/kg groups and the proliferation index of hepatocytes in 30, 45, and 60 mg/kg were markedly decreased when compared with those of control group. At the same time, the percentage of hepatocyte apoptosis was markedly increased in both 45 and 60 mg/kg groups. The results showed that dietary vanadium in the range of 45 ∼ 60 mg/kg caused cell cycle arrest and apoptosis of hepatocytes in broilers.
authors.affiliation: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan, 625014, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Liu
authors.forename: Heng-min
authors.initials: HM
authors.lastname: Cui
authors.forename: Xi
authors.initials: X
authors.lastname: Peng
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Bangyuan
authors.initials: B
authors.lastname: Wu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D002645:Chickens; D004032:Diet; D005434:Flow Cytometry; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D014639:Vanadium / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D014639:Vanadium