title: On the selective elimination of Y-bearing sperm.
abstract: The potential use of antibodies that selectively recognize either X-bearing or Y-bearing sperm is self-evident. Thus our attention was directed to the fact that under optimal conditions, H-Y antibody lyses 50% of mouse spermatozoa. Accordingly, we asked whether expression of H-Y antigen is haploid in spermatozoa from XY male mice heterozygous for the autosomal dominantSxr gene, for if H-Y expression were haploid, H-Y antibody would be expected to kill 75% of spermatozoa derived from these XY,Sxr/- males. However, maximal lysis remained at the 50% level, which indicates that haploid expression of H-Y antigen and the potential immunoselection of Y-(or X-) bearing spermatozoa are unlikely.
authors.affiliation: Department of Biology, City of Hope National Medical Center, 91010, Duarte, California.
authors.forename: S
authors.initials: S
authors.lastname: Ohno
authors.forename: S S
authors.initials: SS
authors.lastname: Wachtel