title: Extrapolation of toxic indices among test objects.
abstract: Oligochaeta Tubifex tubifex, fish fathead minnow (Pimephales promelas), hepatocytes isolated from rat liver and ciliated protozoan are absolutely different organisms and yet their acute toxicity indices correlate. Correlation equations for special effects were developed for a large heterogeneous series of compounds (QSAR, quantitative structure-activity relationships). Knowing those correlation equations and their statistic evaluation, one can extrapolate the toxic indices. The reason is that a common physicochemical property governs the biological effect, namely the partition coefficient between two unmissible phases, simulated generally by n-octanol and water. This may mean that the transport of chemicals towards a target is responsible for the magnitude of the effect, rather than reactivity, as one would assume suppose.
authors.affiliation: National Institute of Public Health, Šrobárova 48, 10042 Praha 10, Czech Republic.
authors.forename: Miloň
authors.initials: M
authors.lastname: Tichý
authors.forename: Marián
authors.initials: M
authors.lastname: Rucki
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Roth
authors.forename: Iveta
authors.initials: I
authors.lastname: Hanzlíková
authors.forename: Alena
authors.initials: A
authors.lastname: Vlková
authors.forename: Jana
authors.initials: J
authors.lastname: Tumová
authors.forename: Rút
authors.initials: R
authors.lastname: Uzlová