title: Successful preferential formation of a novel macromolecular assembly--trilayered polymeric micelle--that can incorporate hydrophilic compounds: the optimization of factors affecting the micelle formation from amphiphilic block copolymers.
abstract: We have developed a novel macromolecular assembly, trilayered polymeric micelle, which can incorporate hydrophilic compounds. The micelle can be prepared from the amphiphilic block copolymers without regard to their properties such as the copolymer's charges and the homogeneity of the copolymers forming the micelle's inner and outer parts. In this study, we investigated the optimal condition for the preferential formation of the trilayered polymeric micelle. GPC results clarified that the composition of the block copolymer, the concentration of PVA in the aqueous bulk phase, and the temperature during the preparation were the important preparation factors affecting preferential formation of the trilayered polymeric micelles. We successfully achieved the preferential formation of the trilayered polymeric micelles under optimal conditions. Furthermore, we confirmed that the model hydrophilic compound, FITC-dextran, was successfully encapsulated into the hydrophilic core of the trilayered polymeric micelles. The novel micelle that can incorporate hydrophilic compounds can have a variety of future medical applications such as a protein delivery-based therapy.
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Faculty of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Uchida
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Murakami
mesh_terms: D003692:Delayed-Action Preparations; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D011108:Polymers; C542623:monomethoxypolyethyleneglycol-polylactide block copolymer; D011092:Polyethylene Glycols