title: Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling.
abstract: BACKGROUND
  Genomic risk profiling involves the analysis of genetic variations linked through statistical associations to a range of disease states. There is considerable controversy as to how, and even whether, to incorporate these tests into routine medical care.
  
  
  OBJECTIVE
  To assess physician attitudes and uptake of genomic risk profiling among an 'early adopter' practice group.
  
  
  METHODS
  We surveyed members of MDVIP, a national group of primary care physicians (PCPs), currently offering genomic risk profiling as part of their practice.
  
  
  METHODS
  All physicians in the MDVIP network (N = 356)
  
  
  RESULTS
  We obtained a 44% response rate. One third of respondents had ordered a test for themselves and 42% for a patient. The odds of having ordered personal testing were 10.51-fold higher for those who felt well-informed about genomic risk testing (p < 0.0001). Of those who had not ordered a test for themselves, 60% expressed concerns for patients regarding discrimination by life and long-term/disability insurers, 61% about test cost, and 62% about clinical utility. The odds of ordering testing for their patients was 8.29-fold higher among respondents who had ordered testing for themselves (p < 0.0001). Of those who had ordered testing for patients, concerns about insurance coverage (p = 0.014) and uncertain clinical utility (p = 0.034) were associated with a lower relative frequency of intention to order testing again in the future.
  
  
  CONCLUSIONS
  Our findings demonstrate that respondent familiarity was a key predictor of physician ordering behavior and clinical utility was a primary concern for genomic risk profiling. Educational and interpretive support may enhance uptake of genomic risk profiling.
authors.affiliation: Duke Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA. susanne.haga@duke.edu
authors.forename: Susanne B
authors.initials: SB
authors.lastname: Haga
authors.forename: Madeline M
authors.initials: MM
authors.lastname: Carrig
authors.forename: Julianne M
authors.initials: JM
authors.lastname: O'Daniel
authors.forename: Lori A
authors.initials: LA
authors.lastname: Orlando
authors.forename: Ley A
authors.initials: LA
authors.lastname: Killeya-Jones
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Ginsburg
authors.forename: Alex
authors.initials: A
authors.lastname: Cho
mesh_terms: D001291:Attitude of Health Personnel; D005260:Female; D020869:Gene Expression Profiling / Q000706:statistics & numerical data*; D005820:Genetic Testing / Q000706:statistics & numerical data*; D014644:Genetic Variation / Q000235:genetics; D023281:Genomics; D006306:Health Surveys / Q000379:methods; D006801:Humans; D008297:Male; D058007:Physicians, Primary Care; D011320:Primary Health Care / Q000379:methods*