title: Current strategies for subunit and genetic viral veterinary vaccine development.
abstract: Developing vaccines for livestock provides researchers with the opportunity to perform efficacy testing in the natural hosts. This enables the evaluation of different strategies, including definition of effective antigens or antigen combinations, and improvement in delivery systems for target antigens so that protective immune responses can be modulated or potentiated. An impressive amount of knowledge has been generated in recent years on vaccine strategies and consequently a wide variety of antigen delivery systems is now available for vaccine research. This paper reviews several antigen production and delivery strategies other than those based on the use of live viral vectors. Genetic and protein subunit vaccines as well as alternative production systems are considered in this review.
authors.affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid, Spain. brun@inia.es
authors.forename: Alejandro
authors.initials: A
authors.lastname: Brun
authors.forename: Juan
authors.initials: J
authors.lastname: Bárcena
authors.forename: Esther
authors.initials: E
authors.lastname: Blanco
authors.forename: Belén
authors.initials: B
authors.lastname: Borrego
authors.forename: Daniel
authors.initials: D
authors.lastname: Dory
authors.forename: José M
authors.initials: JM
authors.lastname: Escribano
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Le Gall-Reculé
authors.forename: Javier
authors.initials: J
authors.lastname: Ortego
authors.forename: Linda K
authors.initials: LK
authors.lastname: Dixon
mesh_terms: D000818:Animals; D000941:Antigens / Q000096:biosynthesis*; D018985:Epitopes, B-Lymphocyte / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D005822:Genetic Vectors / Q000008:administration & dosage*; D058751:Livestock / Q000378:metabolism; D009975:Orthomyxoviridae / Q000276:immunology; D019444:Vaccines, DNA / Q000096:biosynthesis / Q000494:pharmacology; D022223:Vaccines, Subunit / Q000096:biosynthesis / Q000494:pharmacology; D058425:Vaccines, Virus-Like Particle / Q000096:biosynthesis / Q000494:pharmacology; D014765:Viral Vaccines / Q000096:biosynthesis* / Q000494:pharmacology*; D022701:Virosomes / Q000378:metabolism
chemical_list: D000941:Antigens; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D058425:Vaccines, Virus-Like Particle; D014765:Viral Vaccines; D022701:Virosomes