title: How has neutrophil research improved our understanding of periodontal pathogenesis?
abstract: BACKGROUND
  Neutrophils are the predominant cells responsible for host defence against bacterial infection. Loss of neutrophil defence, due either to deficient number or function, strongly predisposes to bacterial infections such as periodontitis. Yet, the neutrophil oxidative and proteolytic arsenal has also been implicated in perpetrating periodontal tissue damage in periodontitis.
  
  
  OBJECTIVE
  In this review, we focus on recent developments that shed light on these two aspects of neutrophil function in periodontitis.
  
  
  METHODS
  Primary search: using PubMed search for "neutophil", "periodontal", and "periodontitis". Secondary search: using references from the articles found in the first stage.
  
  
  RESULTS
  Early histological studies showed that infiltrating neutrophils form a wall of cells abutting the junctional epithelium in periodontal inflammatory lesions. The chronic standoff between these neutrophils and the bacterial community suggests that bacterial evasion of neutrophil clearance is a major characteristic of periodontitis. Indeed, not all functional neutrophil deficiencies increase the risk of periodontitis, an observation that points the way towards identification of particular anti-bacterial pathways essential for protection against periodontal pathogens. The net result in the majority of periodontitis patients who exhibit normal neutrophil number and function, is that neutrophils accumulate in the periodontal tissue where they are available to participate in tissue destruction. Diminished neutrophil clearance further contributes to the persistence of activated neutrophils in the periodontal tissue.
  
  
  CONCLUSIONS
  Data on the role of neutrophils in the pathogenesis of periodontitis are mixed. Neutrophils are a critical arm of the defence against periodontitis, but bacterial evasion of the neutrophil microbicidal machinery coupled with delayed neutrophil apoptosis may transform the neutrophil from defender to perpetrator. At this stage of knowledge, attempts to induce host modulation through neutrophil suppression or activation are premature.
authors.affiliation: Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Nussbaum
authors.forename: Lior
authors.initials: L
authors.lastname: Shapira
mesh_terms: D001424:Bacterial Infections / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D004846:Epithelial Attachment / Q000276:immunology; D006801:Humans; D057131:Immune Evasion / Q000276:immunology; D018375:Neutrophil Activation / Q000276:immunology; D020556:Neutrophil Infiltration / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D010587:Phagocytosis / Q000276:immunology