title: How cells use pseudopods for persistent movement and navigation.
abstract: Pseudopods are cell extensions used for movement. The direction and trajectory of cell movement depend on how cells extend pseudopods. Experimental data show that new pseudopods are frequently formed by the splitting of an existing pseudopod, often as a series of left-right extensions. Here, these data on pseudopod extensions are discussed in the context of a theoretical model for pseudopod splitting.
authors.affiliation: Department of Cell Biochemistry, University of Groningen, Nijenborg 7, 9747AG Groningen, Netherlands. p.j.m.van.haastert@rug.nl
authors.forename: Peter J M
authors.initials: PJ
authors.lastname: Van Haastert
mesh_terms: D000465:Algorithms; D000818:Animals; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002633:Chemotaxis / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004023:Dictyostelium / Q000166:cytology / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D019169:Jurkat Cells; D008954:Models, Biological; D009068:Movement / Q000502:physiology; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D054467:Phospholipases A2 / Q000378:metabolism; D011554:Pseudopodia / Q000502:physiology*; D011953:Receptors, Cyclic AMP / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D018631:ras Proteins / Q000378:metabolism
chemical_list: D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP; D019869:Phosphatidylinositol 3-Kinases; D054467:Phospholipases A2; D019204:GTP-Binding Proteins; D018631:ras Proteins; D006152:Cyclic GMP