title: Role of decoy molecules in neuronal ischemic preconditioning.
abstract: OBJECTIVE
  Decoy receptors bind with TNF related apoptosis inducing ligands (TRAIL) but do not contain the cytoplasmic domains necessary to transduce apoptotic signals. We hypothesized that decoy receptors may confer neuronal protection against lethal ischemia after ischemic preconditioning (IPC).
  
  
  METHODS
  Mixed cortical neurons were exposed to IPC one day prior to TRAIL treatment or lethal ischemia.
  
  
  RESULTS
  IPC increased decoy receptor but reduced death receptor expression compared to lethal ischemia. IPC-induced increase in decoy receptor expression was reduced by prior treatment with CAPE, a nuclear factor-kappa B inhibitor (NFκB).
  
  
  CONCLUSIONS
  Expression of decoy molecules, dependent on NFκB, may mediate neuronal survival induced by IPC.
authors.affiliation: Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Mathivadhani
authors.initials: M
authors.lastname: Panneerselvam
authors.forename: Piyush M
authors.initials: PM
authors.lastname: Patel
authors.forename: David M
authors.initials: DM
authors.lastname: Roth
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kidd
authors.forename: Blake
authors.initials: B
authors.lastname: Chin-Lee
authors.forename: Brian P
authors.initials: BP
authors.lastname: Head
authors.forename: Ingrid R
authors.initials: IR
authors.lastname: Niesman
authors.forename: Satoki
authors.initials: S
authors.lastname: Inoue
authors.forename: Hemal H
authors.initials: HH
authors.lastname: Patel
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Davis
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D002109:Caffeic Acids / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism; D005786:Gene Expression Regulation; D019194:Ischemic Preconditioning / Q000379:methods*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D053218:Receptors, Death Domain / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*; D053319:Tumor Necrosis Factor Decoy Receptors / Q000378:metabolism*
chemical_list: D002109:Caffeic Acids; D016328:NF-kappa B; D053218:Receptors, Death Domain; D053221:TNF-Related Apoptosis-Inducing Ligand; D053319:Tumor Necrosis Factor Decoy Receptors; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol