title: Fat tissue morphology of long-term sex steroid deficiency and estrogen treatment in female rats.
abstract: After long-term estradiol deficiency, female rats displayed body mass gain accompanied by an increase in the size of adipocytes, an increase in hyperglycemia, and a decrease in insulinemia. The effects were reversed by daily estradiol treatment. Adiposity was suggested by the increased vascular endothelial growth factor expression in castrated rats, whereas the proliferative effect of estradiol was suggested by the increased fibronectin expression in treated rats.
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Aluana Carlos
authors.initials: AC
authors.lastname: Santana
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Soares da Costa
authors.forename: Luciana
authors.initials: L
authors.lastname: Armada
authors.forename: Gabrielle
authors.initials: G
authors.lastname: de Paula Lopes Gonzalez
authors.forename: Mariana
authors.initials: M
authors.lastname: dos Santos Ribeiro
authors.forename: Aline
authors.initials: A
authors.lastname: de Sousa dos Santos
authors.forename: Jorge Jose
authors.initials: JJ
authors.lastname: de Carvalho
authors.forename: Celly Cristina A
authors.initials: CC
authors.lastname: do Nascimento Saba
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D050154:Adiposity / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004958:Estradiol / Q000172:deficiency* / Q000502:physiology* / Q000627:therapeutic use; D004967:Estrogens / Q000172:deficiency / Q000502:physiology; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D013995:Time; D016896:Treatment Outcome
chemical_list: D004967:Estrogens; D004958:Estradiol