title: 32p-labeled thio-tepa absorption in normal rat bladders: potential guide for intravesical chemotherapy in bladder cancer.
abstract: Bladders of normal rats were used to evaluate the absorption of thio-tepa after intravesical instillation. Thio-tepa labeled with 32P (radioactive phosphorus) was utilized to measure drug concentrations in bladder wall, liver, and bone marrow. Thio-tepa was rapidly absorbed into the general circulation, and significant amounts of isotope were found. Thio-tepa absorption patterns in the normal rat may serve as a guide in adjusting drug dosages when thio-tepa is used intravesically in human beings for the treatment of superficial, papillary bladder tumors.
authors.affiliation: Department of Urology, Columbia University, Institute of Cancer Research, New York, New York, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Puchner
authors.forename: R J
authors.initials: RJ
authors.lastname: Veenema
authors.forename: P
authors.initials: P
authors.lastname: Tomashefsky
authors.forename: T
authors.initials: T
authors.lastname: Pinzus
authors.forename: T
authors.initials: T
authors.lastname: Tannenbaum
mesh_terms: D000042:Absorption; D000283:Administration, Intravesical; D000818:Animals; D005260:Female; D010761:Phosphorus Radioisotopes; D051381:Rats; D011916:Rats, Inbred F344; D013852:Thiotepa / Q000493:pharmacokinetics*; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: D010761:Phosphorus Radioisotopes; D013852:Thiotepa