title: Nutrition and immunity: the effects of the combination of arginine and tryptophan on growth performance, serum parameters and immune response in broiler chickens challenged with infectious bursal disease vaccine.
abstract: To explore the effects of the combination of tryptophan (Trp) and arginine (Arg) on growth performance, serum parameters and immune response of broiler chickens challenged with intermediate plus strain of infectious bursal disease virus vaccine, an in vivo experiment was conducted. A corn-soybean meal-based diet containing different levels of Arg and Trp was used. Cobb500 male broiler chickens from 0 to 49 days of age were subjected to a diet supplemented with the combination of Trp and Arg. Growth performance parameters and serum parameters were measured at 27 and 49 days of age. To evaluate the immunomodulatory effects of the combination of Trp and Arg on the challenged chickens, we measured the serum levels of interferon-α, interferon-γ and immunoglobulin G at 27, 35, 42, and 49 days of age. The results showed that the three evaluated immune system parameters including interferon-α, interferon-γ and immunoglobulin G were significantly enhanced after treatment. This enhancement resulted in the recovery of infectious bursal disease virus-infected chickens compared with controls as confirmed by histopathological examinations. Moreover, serum parameters such as albumin and total protein increased, whereas the treatment decreased (P<0.05) the feed:gain ratio, aspartate amino-transferase, alkaline phosphatase, lactic dehydrogenase, triglyceride and cholesterol. These findings suggest that the combination of Arg and Trp has a regulatory effect on growth performance. Moreover, it modulates the systemic immune response against infectious bursal disease.
authors.affiliation: Department of Animal Science, Faculty of Agriculture, University Putra Malaysia, Serdang, Selangor, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Emadi
authors.forename: F
authors.initials: F
authors.lastname: Jahanshiri
authors.forename: K
authors.initials: K
authors.lastname: Kaveh
authors.forename: M
authors.initials: M
authors.lastname: Hair-Bejo
authors.forename: A
authors.initials: A
authors.lastname: Ideris
authors.forename: A R
authors.initials: AR
authors.lastname: Alimon
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D002645:Chickens / Q000097:blood / Q000254:growth & development / Q000276:immunology; D019587:Dietary Supplements; D004338:Drug Combinations; D007074:Immunoglobulin G / Q000097:blood; D007243:Infectious bursal disease virus / Q000276:immunology*; D016898:Interferon-alpha / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D008297:Male; D014364:Tryptophan / Q000008:administration & dosage*; D014765:Viral Vaccines
chemical_list: D004338:Drug Combinations; D007074:Immunoglobulin G; D016898:Interferon-alpha; D014765:Viral Vaccines; D007371:Interferon-gamma; D014364:Tryptophan; D001120:Arginine