title: Technique for autologous nasal mucosa transplantation in severe ocular surface disease.
abstract: OBJECTIVE
  To describe the detailed surgical technique used for harvesting and transplantation of autologous nasal mucosa grafts for ocular surface reconstruction, to evaluate the clinical results and utility of autologous nasal mucosa grafts in ocular surface diseases.
  
  
  METHODS
  Autologous nasal mucosa was harvested from either the middle or inferior turbinate. It was transplanted on 11 eyes with severe ocular surface diseases including 4 eyes with chemical burns, 2 eyes with thermal burns, 1 eye with Stevens-Johnson syndrome, 1 eye with erythema multiforme major, and 3 eyes with extensively recurred pterygiums. Clinical outcomes were assessed based on ocular manifestation, epithelization, and visual acuity.
  
  
  RESULTS
  The mean follow-up period was 19.9 months (range 13-32 months). Nasal mucosal tissues were safely excised, and their mucosal harvest sites were completely healed in 2 weeks without postoperative complications. All nasal mucosa autograft survived successfully with rapid epithelization, well-developed horizontal vascularization, and abundant mucin secretion. Clinical success, intact ocular surface epithelium without epithelial erosion more than 4 weeks, was achieved in all eyes. There was no recurrence of significant ulceration, conjunctivalization, fibrovascularization, symblepharon, or pterygium.
  
  
  CONCLUSIONS
  Goblet cell transplantation using autologous turbinate nasal mucosa presents a promising treatment method in patients with severe ocular surface disorders.
authors.affiliation: Department of Ophthalmology, College of Medicine, Chung-Ang University, Yongsan Hospital, Seoul, Korea.
authors.forename: Yeoun Sook
authors.initials: YS
authors.lastname: Chun
authors.forename: In Ki
authors.initials: IK
authors.lastname: Park
authors.forename: Jae Chan
authors.initials: JC
authors.lastname: Kim
mesh_terms: D000328:Adult; D002057:Burns, Chemical / Q000601:surgery; D003229:Conjunctival Diseases / Q000601:surgery*; D003316:Corneal Diseases / Q000601:surgery*; D004892:Erythema Multiforme / Q000601:surgery; D005126:Eye Burns / Q000139:chemically induced / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000637:transplantation*; D013508:Ophthalmologic Surgical Procedures; D011625:Pterygium / Q000601:surgery; D019651:Plastic Surgery Procedures; D013048:Specimen Handling; D013262:Stevens-Johnson Syndrome / Q000601:surgery; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology