title: The evaluation of genotoxic potential of ornidazole, nitroimidazole, in lymphocyte culture of patients with amebiasis.
abstract: The genotoxicity study of ornidazole (ONZ) was carried out on human lymphocyte chromosomes, using sister chromatid exchange (SCE) and micronucleus (MN). Thirty-two patients with Entemoeba histolitica infection who received 1000 mg/day for 10 days were included in this study. SCE and MN were measured before and after therapy. A statistically significant increase was observed in the SCE (P < 0.001) and MN frequencies (P < 0.001) after ornidazole therapy. It was concluded that ONZ has a potential geno- and cytotoxic effect in human peripheral lymphocyte cultures. For this reason, further, detailed studies are needed to elucidate the ONZ mechanism of genotoxicity and its carcinogenic potential.
authors.affiliation: Department of Medical Genetics, Karadeniz Technical University Medical Faculty, Trabzon, Turkey.
authors.forename: Mevlit
authors.initials: M
authors.lastname: Ikbal
authors.forename: Gürdal
authors.initials: G
authors.lastname: Yilmaz
authors.forename: Hasan
authors.initials: H
authors.lastname: Dogan
authors.forename: M Yunus
authors.initials: MY
authors.lastname: Alp
authors.forename: A Han
authors.initials: AH
authors.lastname: Cebi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000562:Amebiasis / Q000097:blood / Q000188:drug therapy*; D000563:Amebicides / Q000009:adverse effects*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D015162:Micronucleus Tests; D008875:Middle Aged; D009153:Mutagens / Q000009:adverse effects*; D009950:Ornidazole / Q000009:adverse effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000563:Amebicides; D009153:Mutagens; D009950:Ornidazole