title: Central line-associated bloodstream infections: prevention and management.
abstract: Approximately 80,000 central venous line-associated bloodstream infections (CLA-BSI) occur in the United States each year. CLA-BSI is most commonly caused by coagulase-negative staphylococci, Staphylococcus aureus, Candida spp, and aerobic gram-negative bacilli. These organisms commonly gain entrance in into the bloodstream via the catheter-skin interface (insertion site) or via the catheter hub. Use of strict aseptic technique for insertion is the key method for the prevention of CLA-BSI. Various methods can be used to reduce unacceptably high rates of CLA-BSI, including use of an antiseptic- or antibiotic-impregnated catheter, daily chlorhexidine baths/washes, and placement of a chlorhexidine-impregnated sponge over the insertion site.
authors.affiliation: Division of Infectious Diseases, University of North Carolina School of Medicine, 2163 Bioinformatics, 130 Mason Farm Road, Chapel Hill, NC 27599-7030, USA. dweber@unch.unc.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Weber
authors.forename: William A
authors.initials: WA
authors.lastname: Rutala
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D016470:Bacteremia / Q000517:prevention & control* / Q000628:therapy; D055499:Catheter-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002408:Catheters, Indwelling / Q000009:adverse effects* / Q000382:microbiology; D003428:Cross Infection / Q000517:prevention & control; D006801:Humans; D018805:Sepsis / Q000517:prevention & control
chemical_list: D000891:Anti-Infective Agents, Local