title: [Effect of rhodiola on serum troponin 1, cardiac integral backscatter and left ventricle ejective fraction of patients who received epirubicin-contained chemotherapy].
abstract: OBJECTIVE
  To investigate the myocardial protective effect of Rhodiola on patients who received epidoxorubicin (EPI) treatment.
  
  
  METHODS
  Forty-two patients with myocardial damage who received 3 courses of EPI-contained chemotherapy were randomly and equally assigned to two groups, the Rhodiola treated group and the control group. After 1-month treatment, the changes in serum troponin I (cTnI) level, cardiac integral backscatter (IBS), and left ventricle ejective fraction (LVEF) in patients were observed and compared between groups.
  
  
  RESULTS
  Levels of cTnI in the treated group and control group were (0.54 +/- 0.05) mg/L and (0.98 +/- 0.03) mg/L respectively, IBS were 55.23 +/- 5.72 scores and 61.23 +/- 5.96 scores, and LVEF (%) were 68 +/- 3 and 57 +/- 2 respectively, all showed significant differences between groups (P<0.05).
  
  
  CONCLUSIONS
  Rhodiola can improve cardiac function, and suppress the increase of serum cTnI level and IBS in patients who received EPI treatment.
authors.affiliation: Affiliated Jiangyin Hospital, Medical College of Southeast University, Jiangsu 214400.
authors.forename: Wei-sheng
authors.initials: WS
authors.lastname: Shen
authors.forename: Chun-heng
authors.initials: CH
authors.lastname: Gao
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000601:surgery; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D008517:Phytotherapy; D011184:Postoperative Period; D020011:Protective Agents / Q000627:therapeutic use; D029771:Rhodiola / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000601:surgery; D013318:Stroke Volume / Q000187:drug effects*; D019210:Troponin I / Q000097:blood*
chemical_list: D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D019210:Troponin I; D015251:Epirubicin