title: Synthetic studies toward A-74528.
abstract: A potentially biomimetic approach toward the complex polyketide A-74528 is described. It is based on highly substituted biaryl compounds, synthesized using advanced cross-coupling and condensation methodologies.
authors.affiliation: Department of Chemistry and Pharmacology, Ludwig-Maximilians-Universität, and Center for Integrated Protein Science, 81377 Munich, Germany.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Hager
authors.forename: Dmitry
authors.initials: D
authors.lastname: Mazunin
authors.forename: Peter
authors.initials: P
authors.lastname: Mayer
authors.forename: Dirk
authors.initials: D
authors.lastname: Trauner
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
chemical_list: C506219:A-74528; D001688:Biological Products; D011083:Polycyclic Compounds; D011753:Pyrones