title: Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study.
abstract: Postmortem and genetic studies have clearly demonstrated changes in GABA(B) receptors in neuropsychiatric disorders such as autism, bipolar disorder, major depression, and schizophrenia. Moreover, a number of recent studies have stressed the importance of cerebellar dysfunction in these same disorders. In the current study, we examined protein levels of the two GABA(B) receptor subunits GABBR1 and GABBR2 in lateral cerebella from a well-characterized cohort of subjects with schizophrenia (n=15), bipolar disorder (n=14), major depression (n=13) and healthy controls (n=12). We found significant reductions in protein for both GABBR1 and GABBR2 in lateral cerebella from subjects with schizophrenia, bipolar disorder and major depression when compared with controls. These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention.
authors.affiliation: Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA. fatem002@umn.edu
authors.forename: S Hossein
authors.initials: SH
authors.lastname: Fatemi
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Folsom
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thuras
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000378:metabolism*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000378:metabolism* / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011180:Postmortem Changes; D018080:Receptors, GABA-B / Q000172:deficiency*; D012559:Schizophrenia / Q000378:metabolism / Q000473:pathology*
chemical_list: D000199:Actins; C485503:GABBR2 protein, human; D018080:Receptors, GABA-B; D010751:Phosphopyruvate Hydratase