title: Psychiatric comorbidity in patients with two prototypes of focal versus generalized epilepsy syndromes.
abstract: The frequency of psychiatric disorders (PD) in a homogeneous series of patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS) compared to patients with juvenile myoclonic epilepsy (JME) was evaluated, aiming to determine the frequency of PD and possible differences in psychiatric diagnoses between these two epileptic syndromes. Data from 248 patients with refractory TLE-MTS and from 124 JME patients were reviewed and compared. There was a high prevalence of PD in both groups of epilepsy patients, present in 100 TLE-MTS (41%) and in 58 JME patients (46.7%). Mood (23.7%), anxiety (13.7%) and psychotic (11.6%) disorders were the most frequent diagnoses in TLE-MTS group, while mood and anxiety disorders (25% and 21%, respectively) were the most common PD among JME. Psychoses were significantly associated with TLE-MTS (p=0.01). These observations are concordant with our previous study, reforcing the existence of a possible anatomic correlation of PD and brain structures involved in both epilepsy syndromes.
authors.affiliation: Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. filho.gerardo@gmail.com
authors.forename: Gerardo Maria de Araújo
authors.initials: GM
authors.lastname: Filho
authors.forename: Lenon
authors.initials: L
authors.lastname: Mazetto
authors.forename: Joyce Macedo
authors.initials: JM
authors.lastname: da Silva
authors.forename: Luís Otávio Sales Ferreira
authors.initials: LO
authors.lastname: Caboclo
authors.forename: Elza Márcia Targas
authors.initials: EM
authors.lastname: Yacubian
mesh_terms: D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology*; D008875:Middle Aged; D020190:Myoclonic Epilepsy, Juvenile / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology*; D013577:Syndrome; D055815:Young Adult