title: The influence of diabetes on the relationship between N-terminal pro-B-type natriuretic peptide and body mass index.
abstract: This study evaluated the influence of diabetes on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and body mass index (BMI). Simultaneous NT-proBNP and echocardiographic Doppler examinations were performed in 1117 patients with dyspnoea undergoing cardiac catheterization. Patients were divided into BMI > or =25 kg/m2 (obese), 23-25 kg/m2 (overweight) and <23 kg/m2 (non-obese) groups. In the 803 non-diabetic patients, mean plasma NT-proBNP levels in non-obese, overweight and obese patients showed a significant negative correlation with BMI (862.3 +/- 228.8 pg/ml, 611.5 +/- 149.7 pg/ml, 278.3 +/- 172.5 pg/ml, respectively). In the 314 patients with diabetes, there was no correlation between BMI and NT-proBNP. This study demonstrated that obese patients had reduced concentrations of NT-proBNP compared with non-obese patients, despite having higher left ventricular filling pressures. NT-proBNP was not reduced in obese patients with diabetes. These results suggest that factors other than cardiac status impact on NT-proBNP concentration.
authors.affiliation: Department of Internal Medicine, Pusan National University Hospital, Pusan National University College of Medicine, Busan, Republic of Korea.
authors.forename: B H
authors.initials: BH
authors.lastname: Kim
authors.forename: I J
authors.initials: IJ
authors.lastname: Kim
authors.forename: K I
authors.initials: KI
authors.lastname: Cho
authors.forename: S M
authors.initials: SM
authors.lastname: Kim
authors.forename: H G
authors.initials: HG
authors.lastname: Lee
authors.forename: T I
authors.initials: TI
authors.lastname: Kim
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000503:physiopathology; D001823:Body Composition; D015992:Body Mass Index; D006328:Cardiac Catheterization; D048909:Diabetes Complications / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004417:Dyspnea / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009765:Obesity / Q000503:physiopathology; D050177:Overweight / Q000503:physiopathology; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*
chemical_list: D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain