title: Peripheral ossifying fibroma and juxtacortical chondrosarcoma in cynomolgus monkeys (Macaca fascicularis).
abstract: Literature on spontaneous primary bone tumors in nonhuman primates is sparse. This case report describes 2 different neoplastic bone lesions in 2 adult cynomolgus monkeys (Macaca fascicularis), including macroscopic, radiographic, histologic, and immunohistochemical findings. In one monkey, a firm mass located at the palatogingival junction of the left rostral maxilla was confirmed to be a peripheral ossifying fibroma in light of its histologic and immunohistochemical characteristics. In another monkey, a lobulated tumor at the right distal femur that radiographically showed moderate radiopacity with splotchy areas of mineralization was confirmed to be a juxtacortical chondrosarcoma on histologic examination. The 2 neoplastic bone lesions revealed rare histologic and immunohistochemical characteristics and contribute to the known tumor spectrum of cynomolgus monkeys.
authors.affiliation: Department of Veterinary Services and Colony Management, Covance Laboratories GmbH, Muenster, Germany. barthel.schmelting@covance.com
authors.forename: Barthel
authors.initials: B
authors.lastname: Schmelting
authors.forename: Martina
authors.initials: M
authors.lastname: Zöller
authors.forename: Joachim
authors.initials: J
authors.lastname: Kaspareit
mesh_terms: D000818:Animals; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D018214:Fibroma, Ossifying / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008252:Macaca fascicularis; D008297:Male; D008441:Maxillary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008992:Monkey Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D018217:Osteosarcoma, Juxtacortical / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D011859:Radiography