title: [Hereditary vascular malformations: classification, symptoms, diagnostics and prognosis].
abstract: The understanding of hereditary vascular anomalies was hampered for a long time by unclear und unspecific terminology. Today, the classification of the International Society for the Study of Vascular Anomalies (ISSVA) differentiates between vascular tumours (mostly infantile haemangioma) with active endothelial proliferation and regression and vascular malformations (VM), which are defects of the vascular morphogenesis and are distinguished in predominantly venous, arterial, capillary, lymphatic, arteriovenous or combined VM. Symptoms are pain, swelling and restricted movement, accompanied by skin signs like dys-plastic veins and capillary VM (naevus flammeus). Thrombophlebitis and chronic venous insufficiency are related to venous VM. Arteriovenous VM are progressive and can cause ischaemic necroses, in rare cases even a high-output cardiac fail-ure. Lymphatic VM lead to localised swelling, in the long run often to recurrent erysipelas and lymphorroea. Primary imaging is provided by -ul-trasound including flow measurements. Mor-phol-ogy and organ involvement is best delineated by magnetic resonance imaging. Phlebography is used to image deep venous system anomalies and is always accompanied by varicography of the dysplastic parts of the venous VM. Digital subtraction angiography is performed to demon-strate the flow pattern in feeding arteries, the nidus and the drainage veins of arteriovenous VM. Besides size and localisation the prognosis of the patients is determined by the pressure (the high-er the pressure, the poorer the prognosis) and the flow rate (the higher the flow rate, the poorer the prognosis) in the VM. Diagnosis and treatment of these rare diseases are best performed in special-ised, interdisciplinary centres.
authors.affiliation: Klinikum Augsburg, Interdisziplinärer Funktionsbereich Angeborene Gefäßfehler, Augsburg, Deutschland. walter.wohlgemuth@klinikum-augsburg.de
authors.forename: W A
authors.initials: WA
authors.lastname: Wohlgemuth
authors.forename: K
authors.initials: K
authors.lastname: Wölfle
authors.forename: T
authors.initials: T
authors.lastname: Schuster
authors.forename: G
authors.initials: G
authors.lastname: Schlimok
authors.forename: K
authors.initials: K
authors.lastname: Bohndorf
mesh_terms: D015901:Angiography, Digital Subtraction; D001165:Arteriovenous Malformations / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D006391:Hemangioma / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D044148:Lymphatic Abnormalities / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D018810:Magnetic Resonance Angiography; D019339:Port-Wine Stain / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D011379:Prognosis; D012878:Skin Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D012955:Societies, Medical; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics; D014463:Ultrasonography; D054079:Vascular Malformations / Q000145:classification* / Q000175:diagnosis / Q000235:genetics*; D014680:Veins / Q000002:abnormalities