title: Delayed response of amylin levels after an oral glucose challenge in children with Prader-Willi syndrome.
abstract: OBJECTIVE
  Amylin secretion is increased parallel to insulin in obese subjects. Despite their marked obesity, a state of relative hypoinsulinemia occurs in children with Prader-Willi syndrome (PWS). Based on the hypothesis that amylin levels may be relatively low in PWS children, contributing to their excessive appetite, we studied amylin levels after oral glucose loading in children with PWS and overweight controls.
  
  
  METHODS
  Plasma levels of amylin, glucagon, insulin, and glucose were measured at 0, 30, 60, 90, and 120 min after a glucose challenge in children with PWS (n = 18) and overweight controls (n = 25); the relationships among the variables were investigated in these two groups.
  
  
  RESULTS
  Amylin levels were significantly correlated with insulin during fasting and during the oral glucose tolerance test in both groups. Amylin levels between 0 and 60 min after glucose loading were statistically different between the two groups. They were lower in children with PWS than in the controls between 0 and 30 min after glucose loading.
  
  
  CONCLUSIONS
  The relatively low levels of amylin, compared to those in overweight controls, during the early phase of glucose loading in patients with PWS, may contribute, in part, to the excessive appetite of PWS patients as compared to the overweight controls.
authors.affiliation: Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Yon Ho
authors.initials: YH
authors.lastname: Choe
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Sohn
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Park
authors.forename: Jun Seok
authors.initials: JS
authors.lastname: Son
authors.forename: Seon Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Dong-Kyu
authors.initials: DK
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D005260:Female; D005934:Glucagon / Q000097:blood; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D058228:Islet Amyloid Polypeptide / Q000097:blood* / Q000502:physiology; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D011218:Prader-Willi Syndrome / Q000097:blood / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D005934:Glucagon; D005947:Glucose