title: [Synthesis of secasterol and 24-episecasterol and their toxicity in MCF-7 cells].
abstract: A convergent synthesis of biosynthetic precursors of brassinosteroids - secasterol and 24-episecasterol with Δ²-bond in cycle A is described. The key stages in the construction of the side chain of these compounds were Julia olefination of steroid 22-aldehyde followed by asymmetric Sharpless dihydroxylation of the intermediate Δ²²-olefin. Toxicity of synthesized compounds against breast carcinoma MCF-7 cells was studied.
authors.forename: V A
authors.initials: VA
authors.lastname: Khripach
authors.forename: V N
authors.initials: VN
authors.lastname: Zhabinskiĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Gyliakevich
authors.forename: O V
authors.initials: OV
authors.lastname: Konstantinova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Misharin
authors.forename: A R
authors.initials: AR
authors.lastname: Mekhtiev
authors.forename: V P
authors.initials: VP
authors.lastname: Timofeev
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Tkachev
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D006888:Hydroxycholesterols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: C477919:(22R,23R,24S)-22,23-dihydroxy-24-methyl-5alpha-cholest-2-en-6-one; D000970:Antineoplastic Agents; D003603:Cytotoxins; D006888:Hydroxycholesterols