title: A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio.
abstract: The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ∼1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24h after physical exercise.
authors.affiliation: School of Environmental Sciences, University of Camerino, Via Gentile III da Varano, Camerino 62032, Italy. Electronic address: daniela.beghelli@unicam.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Beghelli
authors.affiliation: Centre of Nutrition and Ageing, IRCCS - INRCA, Via Birarelli 8, Ancona 60121, Italy.
authors.forename: Robertina
authors.initials: R
authors.lastname: Giacconi
authors.affiliation: Centre of Nutrition and Ageing, IRCCS - INRCA, Via Birarelli 8, Ancona 60121, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Mocchegiani
authors.affiliation: Centre of Nutrition and Ageing, IRCCS - INRCA, Via Birarelli 8, Ancona 60121, Italy.
authors.forename: Catia
authors.initials: C
authors.lastname: Cipriano
authors.affiliation: Centre of Nutrition and Ageing, IRCCS - INRCA, Via Birarelli 8, Ancona 60121, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Malavolta
authors.affiliation: School of Environmental Sciences, University of Camerino, Via Gentile III da Varano, Camerino 62032, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Renieri
mesh_terms: D000818:Animals; D003300:Copper / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005838:Genotype; D006736:Horses / Q000097:blood / Q000235:genetics*; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D007501:Iron / Q000097:blood; D020084:Long Interspersed Nucleotide Elements; D020641:Polymorphism, Single Nucleotide; D012643:Selenium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood*
chemical_list: D015850:Interleukin-6; D014131:Trace Elements; D003300:Copper; D007501:Iron; D012643:Selenium; D015032:Zinc