title: [Chromosome nucleolus-forming regions in assessment of neoadjuvant radiation and combined therapy for glandular breast carcinoma].
abstract: The findings of a change in the content of the main types of nucleoli and argentophilic granules involved in the structural organization, formation of active forms allow evaluation of the efficiency of radiation exposure and its combined modes during neoadjuvant therapy for glandular breast carcinoma by cytogenetic studies. A comparative study of chromosome nucleolus-forming regions before and after neoadjuvant radiotherapy and its combined modes with polychemo- and hormone therapy makes it possible to detect such aspects of therapeutic pathomorphism as the signs of tumor cell destruction and death, which appear after radiotherapy in combination with polychemotherapy.
authors.forename: T N
authors.initials: TN
authors.lastname: Tuganova
authors.forename: L S
authors.initials: LS
authors.lastname: Bolgova
authors.forename: O I
authors.initials: OI
authors.lastname: Alekseenko
authors.forename: M G
authors.initials: MG
authors.lastname: Makhortova
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000648:ultrastructure; D002466:Cell Nucleolus / Q000648:ultrastructure*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D009375:Neoplasms, Glandular and Epithelial / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000648:ultrastructure; D011859:Radiography
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal