title: Combined protective effects of anti-PhtD and anti-pneumococcal polysaccharides.
abstract: In the past years, a significant rise in the proportion of childhood complicated pneumonia cases related to pneumococcal serotypes 1 and 3 has been observed. PhtD is a vaccine candidate protein antigen. By using a pneumococcal lethal intranasal challenge mouse model, a significant additive effect on protection was observed with the combination of vaccination-induced anti-PhtD and injected anti-polysaccharide antibodies specific for serotypes 1 and 3.
authors.affiliation: Research & Development, GlaxoSmithKline Biologicals, Rue de l'Institut 89, B-1330 Rixensart, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Denoël
authors.forename: Fabrice
authors.initials: F
authors.lastname: Godfroid
authors.forename: Philippe
authors.initials: P
authors.lastname: Hermand
authors.forename: Vincent
authors.initials: V
authors.lastname: Verlant
authors.forename: Jan
authors.initials: J
authors.lastname: Poolman
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage* / Q000276:immunology*; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D051379:Mice; D011008:Pneumococcal Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012376:Rodent Diseases / Q000276:immunology / Q000401:mortality / Q000517:prevention & control; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000472:pathogenicity; D016019:Survival Analysis
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial