title: Cyclosporin combined with methotrexate in two patients with recalcitrant subacute cutaneous lupus erythematosus.
abstract: The treatment of subacute cutaneous lupus erythematosus is a therapeutic challenge. Frequently, patients are resistant to or intolerant towards single selected immunosuppressants. In combination, lower doses of methotrexate and cyclosporin A might be used to minimize toxicity. This is the first report of a successful combination of these drugs in two patients suffering from subacute cutaneous lupus erythematosus refractory to standard treatment.
authors.affiliation: Department of Dermatology, University of Regensburg, Regensburg, Germany. annette.klein@klinik.uni-regensburg.de
authors.forename: Annette
authors.initials: A
authors.lastname: Klein
authors.forename: Thomas
authors.initials: T
authors.lastname: Vogt
authors.forename: Sabrina M
authors.initials: SM
authors.lastname: Wenzel
authors.forename: Martin
authors.initials: M
authors.lastname: Fleck
authors.forename: Michael
authors.initials: M
authors.lastname: Landthaler
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000188:drug therapy*; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D016572:Cyclosporine; D008727:Methotrexate