title: [Study of SOD and PON-1 expression in type 2 diabetes mellitus nephropathy and its clinical significance].
abstract: OBJECTIVE
  To investigate the clinical value of superoxide dismutase (SOD) and paraoxonase-1 (PON-1) in type 2 diabetes mellitus (T₂DM) nephropathy.
  
  
  METHODS
  80 cases of T₂DM patients were divided into T₂DM nephropathy group (ND group, 40 cases), and non-T₂DM nephropathy group (non-ND group, 40 cases), the SOD, PON-1 levels and biochemical levels of the two group were measured, the HOMA-IR was recorded.
  
  
  RESULTS
  The SOD and PON-1 levels of the ND group were lower than the non-ND group, compared the difference was significant (P < 0.05). The FINS, FINS levels and HOMA-IR of the ND group were higher than the non-ND group, compared the difference was significant (P < 0.05). The FBG, PBG2h and HbAlc levels were no significantly different (P > 0.05). Serum SOD, PON-1 levels and HOMA-IR were significantly negatively correlated (r = -0.287, -0.509; P = 0.006, 0.000), serum SOD level and PON-1 level was no significantly correlated (P > 0.05).
  
  
  CONCLUSIONS
  The serum SOD and PON-1 involve in the development of T₂DM nephropathy. Combined detection of serum SOD and PON-1 have important clinical significance for early diagnosis, prevention, treatment and prognosis of T₂DM nephropathy.
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Beihua University Jilin, China. sunyuman750430@hotmail.com
authors.forename: Yu-man
authors.initials: YM
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000201:enzymology*; D003928:Diabetic Nephropathies / Q000201:enzymology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D013482:Superoxide Dismutase; D043303:Aryldialkylphosphatase