title: Propofol mitigates systemic oxidative injury during experimental cardiopulmonary cerebral resuscitation.
abstract: Effects of propofol, an intravenous anesthetic agent that exerts potent antioxidant properties, were investigated in an experimental model of cardiac arrest and cardiopulmonary resuscitation. An extended cardiac arrest with 15 randomized piglets was studied to assess the effect of propofol or its solvent intralipid as the control group. Oxidative stress (as measured by a major F(2)-isoprostane) and inflammation (a major metabolite of PGF(2α)) were evaluated in addition to the hemodynamic evaluation, protein S-100β and in situ tissue brain damage by immunochemistry at sacrifice after 3h of reperfusion following cardiac arrest and restoration of spontaneous circulation (ROSC). ROSC increased jugular bulb plasma levels of F(2)-isoprostane and PGF(2α) metabolite significantly more in controls than in the propofol-treated group. In situ tissue damage after ischemia-reperfusion was variable among the pigs at sacrifice, but tended to be greater in the control than the propofol-treated group. Propofol significantly reduced an ROSC-mediated oxidative stress in the brain.
authors.affiliation: Oxidative Stress and Inflammation (SB), Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden. samar.basu@pubcare.uu.se
authors.forename: Samar
authors.initials: S
authors.lastname: Basu
authors.forename: Adriana
authors.initials: A
authors.lastname: Miclescu
authors.forename: Hari
authors.initials: H
authors.lastname: Sharma
authors.forename: Lars
authors.initials: L
authors.lastname: Wiklund
mesh_terms: D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000378:metabolism; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D028441:F2-Isoprostanes / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D007601:Jugular Veins / Q000187:drug effects; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015742:Propofol / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013552:Swine / Q000378:metabolism
chemical_list: D018686:Anesthetics, Intravenous; D028441:F2-Isoprostanes; D016166:Free Radical Scavengers; D015742:Propofol