title: Repeat low-grade squamous intraepithelial cytology with unsatisfactory colposcopy treated by the loop electrosurgical excision procedure: a retrospective study.
abstract: METHODS
  To evaluate the value of the loop electrosurgical excision procedure (LEEP) for repeat low-grade squamous intraepithelial lesions (LSIL) with unsatisfactory colposcopy and the outcomes of postconization.
  
  
  METHODS
  We performed LEEP in 136 patients and followed them up with colposcopy, cytology, and high-risk HPV (HR-HPV) detection using Hybrid Capture II (HCII).
  
  
  RESULTS
  55.1% of women had CIN 1 in the specimen, 17.6% had CIN 2-3, and 27.2% had no lesion. The sensitivity of detecting persistent/recurrent disease can reach 90.9% when positive post-treatment HR-HPV or first abnormal cervical cytology after LEEP are found, and the specificity is 95.3% when positive post-treatment HR-HPV coexisting with first abnormal cervical cytology after LEEP are detected.
  
  
  CONCLUSIONS
  Repeat LSIL with unsatisfactory colposcopy implies a significant risk of CIN 2-3. LEEP is a rational option to those patients with high-risk HPV infection or dysplastic endocervical curettage. Post-treatment follow-up of patients should include both cytology and HR-HPV testing.
authors.affiliation: Department of Minimally-invasive Gynecology, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Changdong
authors.initials: C
authors.lastname: Li
authors.forename: Jiandong
authors.initials: J
authors.lastname: Wang
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002681:China; D003127:Colposcopy / Q000009:adverse effects* / Q000379:methods; D004598:Electrosurgery / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D016387:Women's Health; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*