title: Transcriptional regulation underlying recovery from a DNA damage-induced arrest.
abstract: When the DNA of a cell is damaged, cell cycle progression is arrested and cell cycle-specific transcription is inhibited. However, cell cycle-specific transcription is required for eventual recovery from the DNA damage-induced arrest. Here we discuss recent findings that demonstrate how transcription is fine-tuned during the DNA damage response and how this controls the capacity to recover from a DNA damage arrest in G(2) phase.
authors.affiliation: UMC Utrecht, the Netherlands.
authors.forename: Mónica
authors.initials: M
authors.lastname: Alvarez-Fernández
authors.forename: René H
authors.initials: RH
authors.lastname: Medema
authors.forename: Arne
authors.initials: A
authors.lastname: Lindqvist
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004249:DNA Damage; D059565:G2 Phase Cell Cycle Checkpoints; D005786:Gene Expression Regulation; D006801:Humans; D014158:Transcription, Genetic