title: Eruptive Kaposi sarcoma: an unusual presentation in an HIV-negative patient.
abstract: Kaposi sarcoma (KS) is an angioproliferative disease associated with human herpes virus 8 (HHV-8) infection. Four clinical variants have been described, all unified by common histopathologic features. We report a case of KS in an elderly Italian man with an unusual clinical presentation characterized by a relatively rapid onset of lesions and an unexplained low CD4 lymphocyte count. We review KS, including the 4 recognized variants, the central histopathologic findings, and various treatment options. In addition, we briefly discuss causes of CD4 lymphocytopenia, including a cursory overview of idiopathic CD4 lymphocytopenia (ICL).
authors.affiliation: Department of Dermatology, Philadelphia College of Osteopathic Medicine/Frankford Hospital, Pennsylvania, USA. molliejan@hotmail.com
authors.forename: Mollie M
authors.initials: MM
authors.lastname: Jan
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Laskas
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Griffin
mesh_terms: D000368:Aged; D000634:Aminoquinolines / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D017679:Cryotherapy; D006801:Humans; D000077271:Imiquimod; D007558:Italy / Q000208:ethnology; D008231:Lymphopenia; D008297:Male; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000628:therapy
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod