title: Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate.
abstract: BACKGROUND
  Cleft lip and cleft palate are common birth defects, affecting about one baby of every 700 born. Feeding these babies is an immediate concern and there is evidence of delay in growth of children with a cleft as compared to those without clefting. In an effort to combat reduced weight for height, a variety of advice and devices are recommended to aid feeding of babies with clefts.
  
  
  OBJECTIVE
  This review aims to assess the effects of these feeding interventions in babies with cleft lip and/or palate on growth, development and parental satisfaction.
  
  
  METHODS
  The following electronic databases were searched: the Cochrane Oral Health Group Trials Register (to 27 October 2010), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 4), MEDLINE via OVID (1950 to 27 October 2010), EMBASE via OVID (1980 to 27 October 2010), PsycINFO via OVID (1950 to 27 October 2010) and CINAHL via EBSCO (1980 to 27 October 2010). Attempts were made to identify both unpublished and ongoing studies. There was no restriction with regard to language of publication.
  
  
  METHODS
  Studies were included if they were randomised controlled trials (RCTs) of feeding interventions for babies born with cleft lip, cleft palate or cleft lip and palate up to the age of 6 months (from term).
  
  
  METHODS
  Studies were assessed for relevance independently and in duplicate. All studies meeting the inclusion criteria were data extracted and assessed for validity independently by each member of the review team. Authors were contacted for clarification or missing information whenever possible.
  
  
  RESULTS
  Five RCTs with a total of 292 babies, were included in the review. Comparisons made within the RCTs were squeezable versus rigid feeding bottles (two studies), breastfeeding versus spoon-feeding (one study) and maxillary plate versus no plate (two studies). No statistically significant differences were shown for any of the primary outcomes when comparing bottle types, although squeezable bottles were less likely to require modification. No difference was shown for infants fitted with a maxillary plate compared to no plate. However, there was some evidence of an effect on weight at 6 weeks post-surgery in favour of breastfeeding when compared to spoon-feeding (mean difference 0.47; 95% confidence interval 0.20 to 0.74).
  
  
  CONCLUSIONS
  Squeezable bottles appear easier to use than rigid feeding bottles for babies born with clefts of the lip and/or palate, however, there is no evidence of a difference in growth outcomes between the bottle types. There is weak evidence that breastfeeding is better than spoon-feeding following surgery for cleft. There was no evidence to suggest that maxillary plates assist growth in babies with clefts of the palate. No evidence was found to assess the use of any types of maternal advice and/or support for these babies.
authors.affiliation: Department of Oral and Dental Sciences, University of Bristol, Lower Maudlin Street, Bristol, UK, BS1 2LY.
authors.forename: Alyson
authors.initials: A
authors.lastname: Bessell
authors.forename: Lee
authors.initials: L
authors.lastname: Hooper
authors.forename: William C
authors.initials: WC
authors.lastname: Shaw
authors.forename: Sheena
authors.initials: S
authors.lastname: Reilly
authors.forename: Julie
authors.initials: J
authors.lastname: Reid
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Glenny
mesh_terms: D001942:Breast Feeding; D002971:Cleft Lip; D002972:Cleft Palate; D003258:Consumer Behavior; D005248:Feeding Methods / Q000295:instrumentation; D006128:Growth; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008447:Maxillofacial Prosthesis; D010290:Parents; D016032:Randomized Controlled Trials as Topic