title: Colostral antibody induced interference of inactivated bluetongue serotype-8 vaccines in calves.
abstract: Since its introduction into northern Europe in 2006, bluetongue has become a major threat to animal health. While the efficacy of commercial vaccines has been clearly demonstrated in livestock, little is known regarding the effect of maternal immunity on vaccinal efficacy. Here, we have investigated the duration and amplitude of colostral antibody-induced immunity in calves born to dams vaccinated against bluetongue virus serotype 8 (BTV-8) and the extent of colostral antibody-induced interference of vaccination in these calves. Twenty-two calf-cow pairs were included in this survey. The median age at which calves became seronegative for BTV was 84 and 112 days as assayed by seroneutralisation test (SNT) and VP7 BTV competitive ELISA (cELISA), respectively. At the mean age of 118 days, 13/22 calves were immunized with inactivated BTV-8 vaccine. In most calves vaccination elicited a weak immune response, with seroconversion in only 3/13 calves. The amplitude of the humoral response to vaccination was inversely proportional to the maternal antibody level prior to vaccination. Thus, the lack of response was attributed to the persistence of virus-specific colostral antibodies that interfered with the induction of the immune response. These data suggest that the recommended age for vaccination of calves born to vaccinated dams needs to be adjusted in order to optimize vaccinal efficacy.
authors.affiliation: UMR 1161 VIROLOGIE ANSES-INRA-ENVA, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), 23 avenue du Général De Gaulle, 94700 Maisons-Alfort, France. damien.vitour@anses.fr.
authors.forename: Damien
authors.initials: D
authors.lastname: Vitour
authors.forename: Jean
authors.initials: J
authors.lastname: Guillotin
authors.forename: Corinne
authors.initials: C
authors.lastname: Sailleau
authors.forename: Cyril
authors.initials: C
authors.lastname: Viarouge
authors.forename: Alexandra
authors.initials: A
authors.lastname: Desprat
authors.forename: Frédéric
authors.initials: F
authors.lastname: Wolff
authors.forename: Guillaume
authors.initials: G
authors.lastname: Belbis
authors.forename: Benoit
authors.initials: B
authors.lastname: Durand
authors.forename: Labib
authors.initials: L
authors.lastname: Bakkali-Kassimi
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Breard
authors.forename: Stéphan
authors.initials: S
authors.lastname: Zientara
authors.forename: Gina
authors.initials: G
authors.lastname: Zanella
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D001819:Bluetongue / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D001820:Bluetongue virus / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control* / Q000821:virology; D003126:Colostrum / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D056724:Immunity, Humoral; D009500:Neutralization Tests / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines