title: Therapy-related myelodysplastic syndrome/acute myeloid leukemia with del(7)(q22) in a patient with de novo AML.
abstract: A 55-year-old Korean woman was initially diagnosed with acute myelomonocytic leukemia (AML). After induction chemotherapy was performed using cytarabine, idarubicin, and G-CSF, complete remission (CR) was subsequently achieved following reinduction chemotherapy using the same chemotherapeutic agents. Thirty-six months after the initial CR, an increase in immature cells (up to 12.0%) was observed in the patient's bone marrow. Because chromosome analysis revealed a karyotype of 46,XX,del(7)(q22) in all of the analyzed cells, the patient was diagnosed with therapy-related myelodysplastic syndrome (t-MDS). Although the patient subsequently received chemotherapy and G-CSF for neutropenia, t-MDS rapidly progressed after 3 months to therapy-related acute myeloid leukemia (t-AML). Although very rare, de novo AML can progress to a secondary MDS/AML with del(7q) after chemotherapy with cytarabine, idarubicin, and G-CSF. Further investigation into the role of genes located in 7q22 may provide more information about the mechanisms of leukemogenesis.
authors.affiliation: Department of Internal Medicine, School of Medicine, Kyung-Hee University, Seoul, Korea.
authors.forename: Yang Gyun
authors.initials: YG
authors.lastname: Kim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Cho
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Oh
authors.forename: Hwi-Joong
authors.initials: HJ
authors.lastname: Yoon
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents