title: Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin.
abstract: Biological therapies can be beneficial in cancer patients. The present study aims to examine the inhibitory mechanism of curcumin on cancer cells in patients with colorectal cancer. The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.
authors.affiliation: Department of General Surgery, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: He
authors.forename: Chuan-Bing
authors.initials: CB
authors.lastname: Shi
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
authors.forename: Fang-Long
authors.initials: FL
authors.lastname: Li
authors.forename: Bao-Lin
authors.initials: BL
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D002100:Cachexia / Q000188:drug therapy* / Q000209:etiology; D015179:Colorectal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D003131:Combined Modality Therapy; D003474:Curcumin / Q000627:therapeutic use*; D013505:Digestive System Surgical Procedures; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D009367:Neoplasm Staging; D011878:Radiotherapy; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; D003474:Curcumin