title: Enantioselective gold-catalyzed functionalization of unreactive sp3 C-H bonds through a redox-neutral domino reaction.
abstract: Selectivity is golden: The first asymmetric redox-neutral domino reaction catalyzed by gold that results in the direct functionalization of unreactive sp(3) C-H bonds has been reported. This method consists of a heterocyclization/1,5-hydride transfer/cyclization reaction and provides synthetically valuable azepines with high enantioselectivities and in high yields (Tf = triflate; see scheme).
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Junliang
authors.initials: J
authors.lastname: Zhang