title: Engaging neuroscience to advance translational research in brain barrier biology.
abstract: The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
authors.affiliation: Oregon Health & Science University, 3181 SW Sam Jackson Park Road L603, Portland, Oregon 97239-2941, USA.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Neuwelt
authors.forename: Björn
authors.initials: B
authors.lastname: Bauer
authors.forename: Christoph
authors.initials: C
authors.lastname: Fahlke
authors.forename: Gert
authors.initials: G
authors.lastname: Fricker
authors.forename: Constantino
authors.initials: C
authors.lastname: Iadecola
authors.forename: Damir
authors.initials: D
authors.lastname: Janigro
authors.forename: Luc
authors.initials: L
authors.lastname: Leybaert
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Molnár
authors.forename: Martha E
authors.initials: ME
authors.lastname: O'Donnell
authors.forename: John T
authors.initials: JT
authors.lastname: Povlishock
authors.forename: Norman R
authors.initials: NR
authors.lastname: Saunders
authors.forename: Frank
authors.initials: F
authors.lastname: Sharp
authors.forename: Danica
authors.initials: D
authors.lastname: Stanimirovic
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Watts
authors.forename: Lester R
authors.initials: LR
authors.lastname: Drewes
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism / Q000627:therapeutic use; D009488:Neurosciences / Q000379:methods / Q000639:trends*; D057170:Translational Research, Biomedical / Q000379:methods / Q000639:trends*
chemical_list: D018696:Neuroprotective Agents