title: Oxidative stress and antioxidant status in Saudi asthmatic patients.
abstract: OBJECTIVE
  Asthma is a chronic inflammatory airway disorder associated with recruitment of inflammatory cells. This study aims to clarify the role of oxidative stress and antioxidant status in the deterioration accompanied asthma.
  
  
  METHODS
  Vitamin E, Vitamin C, superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant status together with the concentrations of lipid peroxides, total nitrates and oxidative DNA damage (8-oxodeoxyguanine) were determined in plasma or whole blood of 47 Saudi asthmatic patients and compared to age-matching control samples.
  
  
  RESULTS
  The present study showed that asthmatic patients have significantly decreased levels of GSH, α-tocopherol, GPx, total antioxidant status and higher levels of SOD, lipid peroxides, total nitrate and 8-oxo-dG. Vitamin C recorded more or less similar levels in both groups.
  
  
  CONCLUSIONS
  Alteration of the selected measured parameters confirms that oxidative stress and defective antioxidant status could represent the primary causative factor in the pathogenesis of asthma.
authors.affiliation: Biochemistry Department, Science College, King Saud University, P.O. box 22452, Zip code 11495, Riyadh, Saudi Arabia.
authors.forename: Nouf O
authors.initials: NO
authors.lastname: Al-Afaleg
authors.forename: Abdulrahman
authors.initials: A
authors.lastname: Al-Senaidy
authors.forename: Afaf
authors.initials: A
authors.lastname: El-Ansary
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D001249:Asthma / Q000097:blood* / Q000378:metabolism*; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D012529:Saudi Arabia; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D009566:Nitrates; D009573:Nitrites; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D013482:Superoxide Dismutase; D003849:Deoxyguanosine; D005978:Glutathione; D024502:alpha-Tocopherol; D001205:Ascorbic Acid