title: Metastatic neoplasms of the ovaries: a clinicopathological study of 97 cases.
abstract: OBJECTIVE
  To present the clinicopathological features of metastatic ovarian neoplasms with emphasis in the diagnostic challenge.
  
  
  METHODS
  This is a retrospective study including 97 patients with pathological diagnosis of metastatic ovarian neoplasms, examined during the decade 2000-2009. The gross, microscopical and immunohistochemical characteristics as well as the clinical data (age of the patients, origin of the neoplasm, symptoms, treatment options) and 5-year survival rates were examined.
  
  
  RESULTS
  The mean age of the patients is 55 years (range 26-78 years). 62.89% of the tumors were metastatic from extragenital organs (from stomach 21.65%, breast 15.46%, colon 15.46%, appendix 3.09%, pancreas 2.06%, lung 1.03% and kidney 1.03%, sarcoma 1.03% melanoma 1.03%) and 37.11% tumors originated from the genital tract. The 3-year survival rates ranged from 25.39% for metastatic ovarian neoplasms originating outside the genital tract up to 29.41% for those originating from the genital tract. Tumor immunohistochemistry is a helpful aid in the differential diagnosis mainly between primary mucinous ovarian tumors and metastatic colon cancers and in the recognition of metastatic breast cancers and other neoplasms of the GI tract.
  
  
  CONCLUSIONS
  The management of metastatic ovarian neoplasms should include specific immunohistochemical methods in order to identify the primary neoplasm site. The differential diagnosis of a pelvic mass should always include metastatic neoplasms of the ovaries.
authors.affiliation: Pathology Laboratory, Aretaieion Hospital, University of Athens, 76, Vas. Sofias Av., Athens, Greece.
authors.forename: Agathi
authors.initials: A
authors.lastname: Kondi-Pafiti
authors.forename: Evi
authors.initials: E
authors.lastname: Kairi-Vasilatou
authors.forename: Christos
authors.initials: C
authors.lastname: Iavazzo
authors.forename: Christina
authors.initials: C
authors.lastname: Dastamani
authors.forename: Konstantia
authors.initials: K
authors.lastname: Bakalianou
authors.forename: Angelos
authors.initials: A
authors.lastname: Liapis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Hassiakos
authors.forename: Stelios
authors.initials: S
authors.lastname: Fotiou
mesh_terms: D000328:Adult; D000368:Aged; D001063:Appendiceal Neoplasms / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008545:Melanoma / Q000473:pathology; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000473:pathology; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000556:secondary*; D010190:Pancreatic Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D012509:Sarcoma / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology; D015996:Survival Rate