title: [Polymorphism at the MDR1 locus as a cause of mefloquine-induced psychosis].
abstract: The use of mefloquine for malaria prophylaxis has been hampered by the drug's adverse effects. Foremost among the latter are neuropsychiatric adverse effects such as dizziness, vivid dreams, epilepsy and psychosis. Recent evidence from studies in mice has implicated the lack of P-glycoprotein at the blood-brain barrier as the cause of these adverse effects. The authors present the case of a 60 year-old man who was hospitalized for psychosis following ingestion of mefloquine for malaria prophylaxis. Genetic studies have found polymorphism at the MDR1 gene with genotypes 3435TT and 2677TT which underlie high levels of mefloquine in the brain.
authors.affiliation: Infectious Diseases Unit, Bnai Zion Medical Center, Haifa. natalia.zaigraykin@b-zion.org.il
authors.forename: Natalia
authors.initials: N
authors.lastname: Zaigraykina
authors.forename: Israel
authors.initials: I
authors.lastname: Potasman
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000962:Antimalarials / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D005838:Genotype; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008297:Male; D015767:Mefloquine / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011605:Psychoses, Substance-Induced / Q000209:etiology*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000962:Antimalarials; D015767:Mefloquine