title: The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population.
abstract: Acute myocardial infarction (AMI) is a multifactorial disease influenced by environmental and genetic factors. The aim of this study was to assess the association of angiotensin II type 1 receptor (ATR1) gene polymorphisms with AMI as well as to evaluate the role of serum angiotensin-converting enzyme (ACE) activity and that of cardiac troponin I (cTnI) in Tunisian AMI patients. One hundred and eighteen AMI patients were compared to 150 healthy controls. ATR1 genotypes were determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The ATR1 A1166C polymorphism was significantly associated with AMI (p = 0.024). CC genotype and C allele frequencies were associated with increased AMI risk [CC vs. AC and AA: OR = 2.06; p = 0.045; 95 % CI (1.02-4.18); C vs. A: OR = 1.68; p = 0.004; 95 % CI (1.17-2.41)]. By multivariate logistic regression analysis, CC genotype, hypertension, diabetes, serum ACE activity and peak-cTnI were significant independent predictors of AMI. Increased serum ACE activity and cTnI peak levels were associated with the CC genotype in AMI patients. In conclusion, the ATR1 A1166C polymorphism is associated with AMI and the CC genotype associated with increased ACE activity and cTnI levels appear to predispose for AMI risk.
authors.affiliation: Laboratoire de Biochimie, UR Human Nutrition and Metabolic Disorders, Faculté de Médecine de Monastir, Tunisie.
authors.forename: Sounira
authors.initials: S
authors.lastname: Mehri
authors.forename: Sinda
authors.initials: S
authors.lastname: Mahjoub
authors.forename: Josef
authors.initials: J
authors.lastname: Finsterer
authors.forename: Amira
authors.initials: A
authors.lastname: Zaroui
authors.forename: Rachid
authors.initials: R
authors.lastname: Mechmeche
authors.forename: Bruno
authors.initials: B
authors.lastname: Baudin
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hammami
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D019210:Troponin I / Q000097:blood; D014416:Tunisia
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1; D019210:Troponin I; D007703:Peptidyl-Dipeptidase A