title: Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma.
abstract: OBJECTIVE
  Pleomorphic adenoma (PA) is the most common salivary gland tumour with a tendency to recur (RPA) and a risk of malignant transformation. Mucin 1 (MUC-1) plays a role in the progression of many tumours and may be a marker to predict RPA. The aim of this study was to evaluate MUC-1 expression in different phases of the adenoma to carcinoma sequence.
  
  
  RESULTS
  Twenty-one cases of PA, 18 cases of RPA, three cases of RPA with focal transformation (TRPA) and 11 cases of carcinoma ex-pleomorphic adenoma (CXPA) were analysed immunohistochemically for MUC1 expression using an antibody to MUC1/DF3. MUC1 reactivity in RPA was stronger than that observed in PA and, in all the different carcinoma groups, MUC-1 expression was significantly higher in carcinoma than in RPA and PA.
  
  
  CONCLUSIONS
  This study has confirmed that MUC-1 is related to the recurrence of PA and that this molecule is associated with malignant transformation of PA with carcinoma cells overexpressing MUC-1.
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil. andresabs@hotmail.com
authors.forename: Andresa Borges
authors.initials: AB
authors.lastname: Soares
authors.forename: Ana Paula Dias
authors.initials: AP
authors.lastname: Demasi
authors.forename: Albina
authors.initials: A
authors.lastname: Altemani
authors.forename: Vera Cavalcanti
authors.initials: VC
authors.lastname: de Araújo
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D018396:Mucin-1 / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D012469:Salivary Glands / Q000378:metabolism / Q000473:pathology
chemical_list: C060192:MUC1 protein, human; D018396:Mucin-1