title: Wound-healing properties of the oils of Vitis vinifera and Vaccinium macrocarpon.
abstract: Vitis vinifera (grape) and Vaccinium macrocarpon (cranberry) are well known medicinal plants; most of the pharmacologically active phytochemicals have been isolated from the skin, fruit juice, fermented extract and alcohol fractions of the plants above. Here, the pharmacological properties of the phytochemical constituents present in oils of cranberry and grape were investigated. The oil of grape and cranberry has been evaluated for their wound healing activity by using an excision wound model in rats. The animals were divided into four groups of six each (n = 6). The experimental group 1 and 2 animals were treated topically with the grape and cranberry oil (100 mg/kg body weight), respectively. The controls were treated with petroleum jelly. The standard group of animals were treated with mupirocin ointment (100 mg/kg body weight). The healing was assessed by the rate of wound contraction and hydroxyproline content. On day 13, animals treated with cranberry oil exhibited a (88.1%) reduction in the wound area compared with grape-oil treated (84.6%), controls (74.1%) and standard group animals (78.4%) (p < 0.001). The hydroxyproline content of the granulation tissue was significantly higher in the animals treated with cranberry and the grape-oil (p < 0.000). Comparative investigation of the curative properties of the oils of V. vinifera and V. macrocarpon revealed a significant result which suggests their wound-healing potential.
authors.affiliation: Department of Preclinical Sciences, The University of the West Indies, St Augustine, Trinidad. shivananda.nayak@sta.uwi.edu
authors.forename: B
authors.initials: B
authors.lastname: Shivananda Nayak
authors.forename: D
authors.initials: D
authors.lastname: Dan Ramdath
authors.forename: Julien R
authors.initials: JR
authors.lastname: Marshall
authors.forename: Godwin
authors.initials: G
authors.lastname: Isitor
authors.forename: Sophia
authors.initials: S
authors.lastname: Xue
authors.forename: John
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000302:isolation & purification; D006097:Granulation Tissue / Q000166:cytology / Q000187:drug effects; D008297:Male; D010636:Phenols / Q000302:isolation & purification; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D029799:Vaccinium macrocarpon / Q000737:chemistry*; D027843:Vitis / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005227:Fatty Acids; D010636:Phenols; D010936:Plant Extracts; D010938:Plant Oils