title: Intralymphatic granulomas as a pathogenic factor in cheilitis granulomatosa/Melkersson-Rosenthal syndrome: report of a case with immunohistochemical and molecular studies.
abstract: Orofacial granulomatosis, an uncommon immunologically mediated disorder, includes cheilitis granulomatosa and Melkersson-Rosenthal syndrome. It is clinically characterized by recurrent or persistent swelling of the orofacial tissues with a spectrum of other orofacial features and sometimes with neurological symptoms. The pathological findings are varied but are often characterized by the presence of noncaseating granuloma. We present a new case of orofacial granulomatosis with unusual histopathological findings, namely, intralymphatic granulomas. These may be the cause of the tissue edema. We demonstrated, by immunohistochemical studies, the lymphatic nature of the vessels affected by the granulomatous process.
authors.affiliation: Departments of Pathology, Ramón y Cajal Hospital, University of Alcalá, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: González-García
authors.forename: Ingrid
authors.initials: I
authors.lastname: Aguayo-Leiva
authors.forename: H
authors.initials: H
authors.lastname: Pian
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fernández-Guarino
authors.forename: Pedro
authors.initials: P
authors.lastname: Jaén-Olasolo
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002613:Cheilitis / Q000378:metabolism / Q000473:pathology*; D004247:DNA / Q000032:analysis; D015329:Gene Rearrangement, T-Lymphocyte; D006099:Granuloma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D042601:Lymphatic Vessels / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008556:Melkersson-Rosenthal Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D015415:Biomarkers; D004247:DNA