title: The contribution of epigenetic memory to immunologic memory.
abstract: Memory T lymphocytes are distinct from antigen-inexperienced naïve T cells in that memory T cells can respond more rapidly when they re-encounter a pathogen. Work over the past decade has begun to define the epigenetic underpinnings of the transcriptional component of the memory T cell response. An emerging theme is the persistence of an active chromatin signature at relevant gene loci in resting memory T cells, even when those genes are transcriptionally inactive. This gives strength to the concept of gene poising, and has shown that memory T lymphocytes are an ideal model in which to further define various mechanisms of epigenetic poising.
authors.affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States.
authors.forename: Valerie P
authors.initials: VP
authors.lastname: Zediak
authors.forename: E John
authors.initials: EJ
authors.lastname: Wherry
authors.forename: Shelley L
authors.initials: SL
authors.lastname: Berger
mesh_terms: D002454:Cell Differentiation; D002843:Chromatin; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D007156:Immunologic Memory; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
chemical_list: D002843:Chromatin