title: Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany.
abstract: BACKGROUND
  Growing interest in multimorbidity is observable in industrialized countries. For Germany, the increasing attention still goes still hand in hand with a small number of studies on multimorbidity. The authors report the first results of a cross-sectional study on a large sample of policy holders (n = 123,224) of a statutory health insurance company operating nationwide. This is the first comprehensive study addressing multimorbidity on the basis of German claims data. The main research question was to find out which chronic diseases and disease combinations are specific to multimorbidity in the elderly.
  
  
  METHODS
  The study is based on the claims data of all insured policy holders aged 65 and older (n = 123,224). Adjustment for age and gender was performed for the German population in 2004. A person was defined as multimorbid if she/he had at least 3 diagnoses out of a list of 46 chronic conditions in three or more quarters within the one-year observation period. Prevalences and risk-ratios were calculated for the multimorbid and non-multimorbid samples in order to identify diagnoses more specific to multimorbidity and to detect excess prevalences of multimorbidity patterns.
  
  
  RESULTS
  62% of the sample was multimorbid. Women in general and patients receiving statutory nursing care due to disability are overrepresented in the multimorbid sample. Out of the possible 15,180 combinations of three chronic conditions, 15,024 (99%) were found in the database. Regardless of this wide variety of combinations, the most prevalent individual chronic conditions do also dominate the combinations: Triads of the six most prevalent individual chronic conditions (hypertension, lipid metabolism disorders, chronic low back pain, diabetes mellitus, osteoarthritis and chronic ischemic heart disease) span the disease spectrum of 42% of the multimorbid sample. Gender differences were minor. Observed-to-expected ratios were highest when purine/pyrimidine metabolism disorders/gout and osteoarthritis were part of the multimorbidity patterns.
  
  
  CONCLUSIONS
  The above list of dominating chronic conditions and their combinations could present a pragmatic start for the development of needed guidelines related to multimorbidity.
authors.affiliation: Department of Primary Medical Care, Center of Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. bussche@uke.de
authors.forename: Hendrik
authors.initials: H
authors.lastname: van den Bussche
authors.forename: Daniela
authors.initials: D
authors.lastname: Koller
authors.forename: Tina
authors.initials: T
authors.lastname: Kolonko
authors.forename: Heike
authors.initials: H
authors.lastname: Hansen
authors.forename: Karl
authors.initials: K
authors.lastname: Wegscheider
authors.forename: Gerd
authors.initials: G
authors.lastname: Glaeske
authors.forename: Eike-Christin
authors.initials: EC
authors.lastname: von Leitner
authors.forename: Ingmar
authors.initials: I
authors.lastname: Schäfer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schön
mesh_terms: D000368:Aged; D002908:Chronic Disease / Q000145:classification / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003710:Demography; D005260:Female; D015577:Geriatric Assessment; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007345:Insurance Claim Review; D008297:Male