title: [Clinical research of selective bronchial artery infusion and chemotherapy of lung cancer].
abstract: BACKGROUND
  To study the effect of selective bronchial artery infusion (BAI) and chemotherapy in the treatment of patients with intermediate and advanced lung cancer.
  
  
  METHODS
  Forty-five cases of advanced lung cancer were treated by BAI, which were compared with 40 cases of advanced lung cancer treated by systemic chemotherapy.
  
  
  RESULTS
  The response rate of BAI (33/44, 75.0%) was better than that of systemic chemotherapy (20/40, 50.0%)( P < 0.05). The side-effect of BAI was lower than that of systemic chemotherapy ( P < 0.05), but one case occured paraplegia after BAI. The response rate of small cell undifferentiated lung cancer, squamous cell carcinoma and adenocarcinoma was 94.5% (17/18), 66.6% (14/21) and 40.0% (2/5) respectively in the BAI group. Significant difference of the response rate was found in squamous cell carcinoma and adenocarcinoma between the two groups ( P < 0.05).
  
  
  CONCLUSIONS
  BAI has better response rate and less toxicity than systemic chemotherapy in intermediate and advanced lung cancer, especially in patients with squamous cell carcinoma. Small cell undifferentiated lung carcinoma should be treated by systemic chemotherapy firstly and then BAI. Adenocarcinoma should be treated by BAI firstly and then other therapy.
authors.affiliation: Department of Respiration, The Second Affiliated Hospital of Lanzhou Medical College, Lanzhou, Gansu 730030, P.R.China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Wan
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Zheng
authors.forename: Junnian
authors.initials: J
authors.lastname: Shi