title: Polymer/hemoglobin assemblies: biodegradable oxygen carriers for artificial red blood cells.
abstract: In routine clinical procedures, blood transfusion is now suffering from the defects of the blood products, like cross-matching, short storage time and virus infection. Various blood substitutes have been designed by researchers through continual efforts. With recent progress in nanotechnology, new types of artificial red blood cells with cellular structure are available. This article aims to describe some artificial red blood cells which encapsulate or conjugate hemoglobin molecules through various approaches, especially the nanoscale self-assembly technique, to mitigate the adverse effects of free hemoglobin molecules. These types of artificial red blood cell systems, which make use of biodegradable polymers as matrix materials, show advantages over the traditional types.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Taihang
authors.initials: T
authors.lastname: Li
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001688:Biological Products; D001802:Blood Substitutes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001803:Blood Transfusion; D004912:Erythrocytes / Q000737:chemistry*; D006454:Hemoglobins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008081:Liposomes; D008823:Micelles; D036103:Nanotechnology / Q000379:methods*; D010100:Oxygen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D001688:Biological Products; D001802:Blood Substitutes; D006454:Hemoglobins; D008081:Liposomes; D008823:Micelles; D011108:Polymers; D010100:Oxygen