title: The genetics of teratocarcinoma transplantation: tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3.
abstract: Two cultured lines of murine embryonal carcinoma, F9 and PCC3, have been grafted to a variety of allogeneic hosts. The host strains have been classified by their resistance or sensitivity to these carcinomas. Resistance seems to be immunological in nature.Allograft rejection does not correlate withH-2 haplotype, and seems to be controlled by a limited number of recessive factors, presumably histocompatibility genes. We infer that these factors have limited polymorphism in the mouse species. Recombinational analysis of strain A/He has revealed the presence of a recessive factor linked to theH-2 locus. Tumor resistance of strains C57BL/6 and AKR appears to result from the interaction of dominant or semi-dominant factors in theH-2 region with other recessive elements in the genetic background.Though F(1) hybrids between resistant mouse strains and the syngeneic strain 129 are largely tumor-sensitive, a low level of hybrid resistance to F9 has been observed and shown to be eliminated by X-irradiation.
authors.affiliation: Laboratoire d'Immunologie et Virologie des Tumeurs, U152, Hôpital Cochin, 75014, Paris, France.
authors.forename: P R
authors.initials: PR
authors.lastname: Avner
authors.forename: W F
authors.initials: WF
authors.lastname: Dove
authors.forename: P
authors.initials: P
authors.lastname: Dubois
authors.forename: J A
authors.initials: JA
authors.lastname: Gaillard
authors.forename: J L
authors.initials: JL
authors.lastname: Guénet
authors.forename: F
authors.initials: F
authors.lastname: Jacob
authors.forename: H
authors.initials: H
authors.lastname: Jakob
authors.forename: A
authors.initials: A
authors.lastname: Shedlovsky