title: Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia.
abstract: The chemical investigation of the twigs of Morus mesozygia resulted in the isolation of three new prenylated 2-arylbenzofurans, named moracin KM, LM, and SC (1-3), nine known 2-arylbenzofurans (4-12), and two known flavonoids (13-14). The structures of the new compounds were established as [2'',3'':6,7]-(6-(S)-hydroxymethyl-6-methylpyrano)-2-(3,5-dihydroxyphenyl)benzofuran-5-ol (1), [2'',3'':6,7]-(4,7-dihydro-6-methyloxepine)-2-(3-hydroxy-5-methoxyphenyl)benzofuran-5-ol (2), and [2'',3'':6,7]-(6,6-dimethylpyrano)-2-(3,5-dihydroxyphenyl)benzofuran (3). One of the new compounds, moracin LM (2), displayed modest antioxidant activity, whereas known compounds 4, 13, and 14 showed significant hepatoprotective and antioxidant activities.
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaoundé I, Yaoundé, Cameroon. dkapche2002@yahoo.com
authors.forename: Gilbert D W F
authors.initials: GD
authors.lastname: Kapche
authors.forename: Dawe
authors.initials: D
authors.lastname: Amadou
authors.forename: Pierre
authors.initials: P
authors.lastname: Waffo-Teguo
authors.forename: Jean H
authors.initials: JH
authors.lastname: Donfack
authors.forename: Christian D
authors.initials: CD
authors.lastname: Fozing
authors.forename: Dominique
authors.initials: D
authors.lastname: Harakat
authors.forename: Angèle N
authors.initials: AN
authors.lastname: Tchana
authors.forename: Jean M
authors.initials: JM
authors.lastname: Mérillon
authors.forename: Paul F
authors.initials: PF
authors.lastname: Moundipa
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Berhanu M
authors.initials: BM
authors.lastname: Abegaz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013055:Spectrophotometry, Infrared; D019207:beta Carotene / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001572:Benzofurans; D005419:Flavonoids; D010936:Plant Extracts; D020011:Protective Agents; D019207:beta Carotene