title: Urinary UMOD excretion and chronic kidney disease in gout patients: cross-sectional case-control study.
abstract: Patients with gout often have concurrent chronic kidney disease (CKD); the relationship between the two conditions is still unclear. Previous studies have identified an association between low level of urinary uromodulin (UMOD) and CKD within the setting of diabetes and lupus. The aim of this study was to examine the association between urinary UMOD excretion and CKD in patients with gout. A total of 53 Taiwanese gout patients with stable disease activity were enrolled. Patients were divided into a CKD group (n = 25) and a non-CKD group (n = 28). Using Pearson correlation analysis, urinary UMOD excretion was positively correlated with estimated glomerular filtration rate (Ha: ρ > 0, p = 0.004). Using multivariate analysis, patients with CKD and gout were associated with lower urinary UMOD excretion than those who have gout alone [odds ratio (95% CI): 0.826 (0.694-0.985), p < 0.001]. Patients with CKD and gout were also more likely to be older (p < 0.001) and have higher uric acid levels (p < 0.001). This study implicates that UMOD might play a role in the relationship between gout and CKD. Further studies with animal models of gout and CKD would be recommended.
authors.affiliation: Division of Nephrology, Chang Gung Memorial Hospital--Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Chien-Hsing
authors.initials: CH
authors.lastname: Wu
authors.forename: Chien-Te
authors.initials: CT
authors.lastname: Lee
authors.forename: Chih-Hsiung
authors.initials: CH
authors.lastname: Lee
authors.forename: Tien-Tsai
authors.initials: TT
authors.lastname: Cheng
authors.forename: Hsueh-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Eton
authors.initials: E
authors.lastname: Lin
authors.forename: Feng-Rong
authors.initials: FR
authors.lastname: Chuang
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Yang
authors.forename: Ying-Chou
authors.initials: YC
authors.lastname: Chen
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Wu
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D005919:Glomerular Filtration Rate; D006073:Gout / Q000150:complications / Q000652:urine*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000652:urine*; D058949:Uromodulin / Q000235:genetics / Q000652:urine*; D055815:Young Adult
chemical_list: C548612:UMOD protein, human; D058949:Uromodulin; D003404:Creatinine