title: Concurrent TMS-fMRI reveals dynamic interhemispheric influences of the right parietal cortex during exogenously cued visuospatial attention.
abstract: We used concurrent transcranial magnetic stimulation and functional MRI (TMS-fMRI) during a visuospatial cueing paradigm in humans, to study the causal role of the right angular gyrus (AG) as a source of attentional control. Our findings show that TMS over the right AG (high vs. low intensity) modulates neural responses interhemispherically, in a manner that varies dynamically with the current attentional condition. The behavioural impact of such TMS depended not only on the target hemifield but also on exogenous cue validity, facilitating spatial reorienting to invalidly cued right visual targets. On a neural level, right AG TMS had corresponding interhemispheric effects in the left AG and left retinotopic cortex, including area V1. We conclude that the direction of covert visuospatial attention can involve dynamic interplay between the right AG and remote interconnected regions of the opposite left hemisphere, whereas our findings also suggest that the right AG can influence responses in the retinotopic visual cortex.
authors.affiliation: UCL Institute of Cognitive Neuroscience and Wellcome Trust Centre for Neuroimaging, University College London, 17 Queen Square, London WC1N 3AR, UK. k.heinen@ucl.ac.uk
authors.forename: Klaartje
authors.initials: K
authors.lastname: Heinen
authors.forename: Christian C
authors.initials: CC
authors.lastname: Ruff
authors.forename: Otto
authors.initials: O
authors.lastname: Bjoertomt
authors.forename: Bertram
authors.initials: B
authors.lastname: Schenkluhn
authors.forename: Sven
authors.initials: S
authors.lastname: Bestmann
authors.forename: Felix
authors.initials: F
authors.lastname: Blankenburg
authors.forename: Jon
authors.initials: J
authors.lastname: Driver
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Chambers
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D003463:Cues; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation