title: Antibacterial activity of 15-deoxygoyazensolide isolated from the stems of Minasia alpestris (Asteraceae) against oral pathogens.
abstract: This work reports the isolation of the sesquiterpene lactone 15-deoxygoyazensolide from the stems of Minasia alpestris and the evaluation of its antimicrobial activity against the following oral pathogens: Enterococcus faecalis, Streptococcus salivarius, Streptococcus sobrinus, Streptococcus mutans, Streptococcus mitis, Streptococcus sanguinis, and Lactobacillus casei. Despite the cytotoxicity and genotoxicity of other sesquiterpene lactones of the furanoheliangolide-type, our results revealed that this compound exhibits low antibacterial activity against the evaluated oral pathogens; however, an interesting selectivity against E. faecalis (minimum inhibitory concentration [MIC]=40 µg mL(-1)) and S. sobrinus (MIC=60 µg mL(-1)) was observed.
authors.affiliation: Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil.
authors.forename: L C
authors.initials: LC
authors.lastname: Keles
authors.forename: F M
authors.initials: FM
authors.lastname: Gianasi
authors.forename: R C
authors.initials: RC
authors.lastname: Souza
authors.forename: B L
authors.initials: BL
authors.lastname: Brito
authors.forename: E H
authors.initials: EH
authors.lastname: Schaab
authors.forename: M G M
authors.initials: MG
authors.lastname: Souza
authors.forename: T C
authors.initials: TC
authors.lastname: Carvalho
authors.forename: C H G
authors.initials: CH
authors.lastname: Martins
authors.forename: R C S
authors.initials: RC
authors.lastname: Veneziani
authors.forename: W R
authors.initials: WR
authors.lastname: Cunha
authors.forename: A E M
authors.initials: AE
authors.lastname: Crotti
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D013293:Enterococcus faecalis / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: C498361:15-deoxygoyazensolide; D000900:Anti-Bacterial Agents; D006575:Heterocyclic Compounds, 3-Ring