title: Donor phosphorus levels and recipient outcomes in living-donor kidney transplantation.
abstract: OBJECTIVE
  In living-donor kidney transplantation, various donor factors, including gender, age, and baseline kidney function, predict allograft function and recipient outcomes after transplantation. Because higher phosphorus is predictive of vascular injury in healthy adults, the effect of donor phosphorus levels on recipient renal function after transplantation was investigated.
  
  
  METHODS
  Phosphorus levels in 241 living donors were analyzed from a 7-year period, and recipient renal function and acute rejection at 1 year posttransplantation were examined controlling for other influencing factors, including multiple donor variables, HLA matching, and acute rejection.
  
  
  RESULTS
  Female and African-American donors had significantly higher phosphorus levels predonation. By multivariable analysis, higher donor phosphorus correlated with higher recipient serum creatinine (slope=0.087, 95% confidence interval [CI]: 0.004 to 0.169, P=0.041) and lower recipient estimated GFR (slope=-4.321, 95% CI: -8.165 to -0.476, P=0.028) at 12 months. Higher donor phosphorus also displayed an independent correlation with biopsy-proven acute rejection and delayed or slow graft function after transplantation.
  
  
  CONCLUSIONS
  In a cohort of living kidney donors, higher donor phosphorus correlated with female gender and African-American ethnicity and was an independent risk factor for early allograft dysfunction after living-donor kidney transplantation.
authors.affiliation: Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Chang
authors.forename: Sharmeela
authors.initials: S
authors.lastname: Saha
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Gomes
authors.forename: Aparna
authors.initials: A
authors.lastname: Padiyar
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Bodziak
authors.forename: Emilio D
authors.initials: ED
authors.lastname: Poggio
authors.forename: Donald E
authors.initials: DE
authors.lastname: Hricik
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Augustine
mesh_terms: D000208:Acute Disease; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000208:ethnology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers; D010758:Phosphorus; D003404:Creatinine