title: Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.
abstract: SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M(1) positive allosteric modulators was examined. While the SAR was generally flat, compounds were identified with high CNS exposure to warrant additional in vivo evaluation.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. scott_d_kuduk@merck.com
authors.forename: Scott D
authors.initials: SD
authors.lastname: Kuduk
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Chang
authors.forename: Christina N
authors.initials: CN
authors.lastname: Di Marco
authors.forename: William J
authors.initials: WJ
authors.lastname: Ray
authors.forename: Lei
authors.initials: L
authors.lastname: Ma
authors.forename: Marion
authors.initials: M
authors.lastname: Wittmann
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Seager
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Koeplinger
authors.forename: Charles D
authors.initials: CD
authors.lastname: Thompson
authors.forename: George D
authors.initials: GD
authors.lastname: Hartman
authors.forename: Mark T
authors.initials: MT
authors.lastname: Bilodeau
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D010880:Piperidines / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D010880:Piperidines