title: Influence of glycemic control on tympanic membrane healing in diabetic rats.
abstract: OBJECTIVE
  It is generally assumed that glycemic control in diabetic patients is important in optimizing wound healing. The goal of this study was to examine tympanic membrane (TM) wound healing in spontaneously diabetic rats depending on the diabetic metabolic state compared to nondiabetic control animals.
  
  
  METHODS
  Prospective controlled study in experimental animals.
  
  
  METHODS
  Right-sided myringotomy was performed in 20 normoglycemic rats, 17 well-compensated, and 23 poorly compensated diabetic rats. TMs were observed for a total of 3 weeks. Effect of diabetic metabolic state on the healing of the TMs was evaluated by closure rates and histology.
  
  
  RESULTS
  Diabetic rats showed a significant delay in TM wound healing compared to the control group, but there were no significant differences between both diabetes groups.
  
  
  CONCLUSIONS
  Glycemic control does not influence TM wound repair in an animal model of type 1 diabetes.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Ernst Moritz Arndt University, Greifswald, Germany. holger.kaftan@uni-greifswald.de
authors.forename: Holger
authors.initials: H
authors.lastname: Kaftan
authors.forename: Lars
authors.initials: L
authors.lastname: Reuther
authors.forename: Bärbel
authors.initials: B
authors.lastname: Miehe
authors.forename: Werner
authors.initials: W
authors.lastname: Hosemann
authors.forename: Ingrid
authors.initials: I
authors.lastname: Klöting
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000235:genetics / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000235:genetics / Q000473:pathology*; D019270:Fructosamine / Q000097:blood*; D051381:Rats; D011913:Rats, Inbred BB; D014432:Tympanic Membrane / Q000473:pathology*; D018058:Tympanic Membrane Perforation / Q000473:pathology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D019270:Fructosamine