title: Ethosuximide and phenobarbital promote wound healing via enhancing collagenization.
abstract: The fact that ethosuximide (ETO), phenobarbital (PHO), and barbituric acid (BARB) share structural and pharmacophoric homologies with phenytoin and allantoin, both known to have significant wound-healing properties, prompted us to evaluate them as wound-healing agents. Accordingly, ETO-, PHO-, and BARB-containing ointments were applied onto full-thickness excision and incision wounds created on the dorso-lumbar region of experimental rats. ETO-and PHO-treated incision wounds illustrated significant enhancement in breaking strengths (1380 ± 61 and 1240 ± 42 g, respectively) compared to vehicle controls (1070 ± 18 g) and BARB (1080 ± 45 g). Moreover, biochemical analyses revealed significant increase in hydroxyproline contents in ETO- and PHO-treated wounds compared to vehicle controls. Histological evaluation revealed that both ETO and PHO promoted collagen synthesis and deposition. This is the first time to describe the significant wound-healing merits of ETO and PHO as potential clinical agents for treatment of chronic wounds.
authors.affiliation: Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan.
authors.forename: Dema M
authors.initials: DM
authors.lastname: Ajwee
authors.forename: Ahmad M
authors.initials: AM
authors.lastname: Disi
authors.forename: Eyad A
authors.initials: EA
authors.lastname: Qunaibi
authors.forename: Mutasem O
authors.initials: MO
authors.lastname: Taha
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D015195:Drug Design; D005013:Ethosuximide / Q000737:chemistry / Q000494:pharmacology*; D006909:Hydroxyproline / Q000737:chemistry; D010634:Phenobarbital / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012984:Software; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005013:Ethosuximide; D003094:Collagen; D006909:Hydroxyproline; D010634:Phenobarbital