title: Umbilical artery pulsatility index and fetal abdominal circumference in isolated gastroschisis.
abstract: OBJECTIVE
  To investigate changes in abdominal circumference (AC) and umbilical artery pulsatility index (UA-PI) with gestation in fetuses with isolated gastroschisis, and to determine whether a relationship exists between UA-PI and fetal AC.
  
  
  METHODS
  Data from 58 pregnancies with isolated gastroschisis diagnosed at between 24 and 36 weeks' gestation were included in the study. Z-scores were calculated with respect to expected UA-PI values in normal pregnancies after log-transformation. AC-Z-scores were calculated with respect to expected size in normal pregnancies according to a standard chart. Functional linear discriminant analysis (FLDA) was applied to generate 50(th), 5(th) and 95(th) percentile curves for changes in both AC and UA-PI with gestational age in fetuses with gastroschisis. These curves were compared with the standard curves, as were the means. UA-PI was also plotted against AC. For this relationship, a robust Spearman correlation coefficient was obtained with FLDA.
  
  
  RESULTS
  In fetuses with gastroschisis, there was a highly significant negative correlation between UA-PI and AC, normalized for gestation using Z-scores (median correlation coefficient, - 0.289; median P = 0.000023). Moreover, compared with standard curves AC was lower and UA-PI higher in the gestational-age range studied. Both the AC and UA-PI curves showed a significantly different rate of change with gestation compared with the normal ranges. The mean values for fetuses with gastroschisis compared with the standard AC and UA-PI range curves were significantly different for AC throughout gestation, and for UA-PI from 32 weeks' gestation.
  
  
  CONCLUSIONS
  In fetal gastroschisis, it is well known that AC tends to be smaller, though UA-PI has not been reported to be abnormal in any consistent way. There is a clear relationship between the fetus's AC for gestation and UA-PI, which is not the case for normally grown fetuses. The data suggest that the growth restriction seen in gastroschisis may be explained by hypoxia, and not simply by the classical explanation of extra-abdominal displacement of the abdominal viscera.
authors.affiliation: Division of Fetal Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: U
authors.initials: U
authors.lastname: Hussain
authors.forename: A
authors.initials: A
authors.lastname: Daemen
authors.forename: H
authors.initials: H
authors.lastname: Missfelder-Lobos
authors.forename: B
authors.initials: B
authors.lastname: De Moor
authors.forename: D
authors.initials: D
authors.lastname: Timmerman
authors.forename: T
authors.initials: T
authors.lastname: Bourne
authors.forename: C
authors.initials: C
authors.lastname: Lees
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging* / Q000196:embryology; D005260:Female; D020139:Gastroschisis / Q000000981:diagnostic imaging* / Q000196:embryology / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D010641:Phenotype; D011247:Pregnancy; D011673:Pulsatile Flow; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging* / Q000196:embryology / Q000503:physiopathology