title: Silicon-based chemistry: an original and efficient one-step approach to [18F]-nucleosides and [18F]-oligonucleotides for PET imaging.
abstract: Take it eaSi! Nucleosides, dinucleotides, and one oligonucleotide, all modified by click chemistry, have for the first time been directly and very efficiently labeled with (18)F by using a silicon-based, one-step approach that opens the way for the development of a new class of positron emission tomography (PET) tracers (see graphic).
authors.affiliation: Université de Bordeaux, LIMF, UMR5231, 146, rue Léo Saignat, Bordeaux, 33076, France.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schulz
authors.forename: Delphine
authors.initials: D
authors.lastname: Vimont
authors.forename: Thomas
authors.initials: T
authors.lastname: Bordenave
authors.forename: Damien
authors.initials: D
authors.lastname: James
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Escudier
authors.forename: Michèle
authors.initials: M
authors.lastname: Allard
authors.forename: Magali
authors.initials: M
authors.lastname: Szlosek-Pinaud
authors.forename: Eric
authors.initials: E
authors.lastname: Fouquet
mesh_terms: D057930:Click Chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*
chemical_list: D005462:Fluorine Radioisotopes; D009841:Oligonucleotides; D019275:Radiopharmaceuticals; D012825:Silicon