title: Polycationic glycosides.
abstract: Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
authors.affiliation: Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA. robert.engel@qc.cuny.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Engel
authors.forename: Ishrat
authors.initials: I
authors.lastname: Ghani
authors.forename: Diego
authors.initials: D
authors.lastname: Montenegro
authors.forename: Marie
authors.initials: M
authors.lastname: Thomas
authors.forename: Barbara
authors.initials: B
authors.lastname: Klaritch-Vrana
authors.forename: Alejandra
authors.initials: A
authors.lastname: Castaño
authors.forename: Laura
authors.initials: L
authors.lastname: Friedman
authors.forename: Jay
authors.initials: J
authors.lastname: Leb
authors.forename: Leah
authors.initials: L
authors.lastname: Rothman
authors.forename: Heidi
authors.initials: H
authors.lastname: Lee
authors.forename: Craig
authors.initials: C
authors.lastname: Capodiferro
authors.forename: Daniel
authors.initials: D
authors.lastname: Ambinder
authors.forename: Eva
authors.initials: E
authors.lastname: Cere
authors.forename: Christopher
authors.initials: C
authors.lastname: Awad
authors.forename: Faiza
authors.initials: F
authors.lastname: Sheikh
authors.forename: Jaimelee
authors.initials: J
authors.lastname: Rizzo
authors.forename: Lisa-Marie
authors.initials: LM
authors.lastname: Nesbitt
authors.forename: Erika
authors.initials: E
authors.lastname: Testani
authors.forename: Karin
authors.initials: K
authors.lastname: Melkonian
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry; D002236:Carbohydrate Conformation; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis / Q000737:chemistry*; D000071228:Polyelectrolytes; D012492:Salts / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006027:Glycosides; D008055:Lipids; D011073:Polyamines; D000071228:Polyelectrolytes; D012492:Salts