title: Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors.
abstract: To determine pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol [25-OH-PPD, 20(R)-dammarane-3β,12β,20,25-tetrol], a promising antitumor natural product isolated from the fruits of Panax ginseng, an analytical method involving liquid chromatography/tandem mass spectrometry in biological samples was developed and employed. After intravenous and oral administration to nude mice bearing xenografts of human pancreatic tumors at doses of 10 and 20 mg/kg body weight, respectively, 25-OH-PPD was rapidly absorbed and distributed in plasma and in all tissues examined, including the tumors, with all Cmax>2 μg/ml or μg/g and tmax<1 h. The absolute oral bioavailability of 25-OH-PPD was relatively high, compared with other ginsenosides. These results indicate that this novel anti-cancer ginsenoside has relatively favorable pharmacokinetic properties and provide a basis for further development of this compound as a chemotherapeutic agent.
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Rm 427, Building 41, 320 Yueyang Road, Shanghai, 200031, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Hao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ruiwen
authors.initials: R
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D001682:Biological Availability; D002853:Chromatography, Liquid; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D036145:Ginsenosides / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008819:Mice, Nude; D005894:Panax / Q000737:chemistry; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D053719:Tandem Mass Spectrometry; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
chemical_list: C529607:25-hydroxyprotopanaxadiol; D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides