title: Evaluation of tenoxicam on prevention of arachnoiditis in rat laminectomy model.
abstract: Post laminectomy arachnoiditis has been shown by experiments with rats and post operative radiological imaging in humans. The purpose of this experimental study was to determine the efficacy of tenoxicam in preventing arachnoiditis in rats. Twenty-four Wistar rats were divided into two groups, and L3 laminectomy was performed. In the tenoxicam group, 0.5 mg/kg tenoxicam was applied intraperitoneally. Normal saline was applied intraperitoneally in the control group. Later, the rats were killed at weeks 3 and 6, and the laminectomy sites were evaluated pathologically for arachnoiditis. The results showed that 6 weeks after surgery, the tenoxicam group showed lowest arachnoiditis grades. However, statistically significant difference was not found in arachnoiditis between the control group and the tenoxicam group. Based on these findings it is concluded that application of the tenoxicam after lumbar laminectomy did not effectively reduce arachnoiditis. Performing the most effective surgical technique without damage around tissue in a small surgical wound and having meticulous hemostasis in surgery seem to be the key for preventing arachnoiditis effectively.
authors.affiliation: Department of Neurosurgery, Fatih University Faculty of Medicine, 06510 Bestepeler, Ankara, Turkey. berker5@yahoo.com
authors.forename: Berker
authors.initials: B
authors.lastname: Cemil
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kurt
authors.forename: Cansel
authors.initials: C
authors.lastname: Aydın
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyurek
authors.forename: Bulent
authors.initials: B
authors.lastname: Erdogan
authors.forename: Necdet
authors.initials: N
authors.lastname: Ceviker
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001099:Arachnoid / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D001100:Arachnoiditis / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery; D004195:Disease Models, Animal; D006488:Hemostasis, Surgical / Q000592:standards; D007274:Injections, Intraperitoneal; D007796:Laminectomy / Q000009:adverse effects* / Q000379:methods / Q000592:standards; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D017211:Treatment Failure
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C032801:tenoxicam