title: ABO blood group and risk of cutaneous malignant melanoma.
abstract: Although, for several decades, the role of ABO blood group antigens has been suspected in the development of cancer, to our knowledge, the association between ABO blood group and the risk of malignant melanoma has not been evaluated yet. We, therefore, examined the relationship between ABO blood group and risk of developing cutaneous malignant melanoma. We retrospectively reviewed 445 patients with a histological diagnosis of malignant melanoma. Blood groups were obtained from medical records. The control group was represented by 38 321 patients. We evaluated the data by investigation with statistical analysis to show a statistically significant increased risk of developing a malignant melanoma in the O Rh-negative group (odds ratio = 1.4). We suggest focus on the melanoma cases belonging to the blood groups O Rh-negative in future studies, because all the clues of this study seem to show a correlation between blood groups and the risk of malignant melanoma among these groups.
authors.affiliation: Department of Dermatology, University of Florence, Via della Pergola 60, Florence, Italy. vincenzo.degiorgi@unifi.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: de Giorgi
authors.forename: Marta
authors.initials: M
authors.lastname: Grazzini
authors.forename: Alessia
authors.initials: A
authors.lastname: Gori
authors.forename: Barbara
authors.initials: B
authors.lastname: Alfaioli
authors.forename: Susanna
authors.initials: S
authors.lastname: Rossari
authors.forename: Emanuele
authors.initials: E
authors.lastname: Crocetti
authors.forename: Franco
authors.initials: F
authors.lastname: Vocioni
authors.forename: Torello
authors.initials: T
authors.lastname: Lotti
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000175:diagnosis; D016017:Odds Ratio; D012189:Retrospective Studies; D012204:Rh-Hr Blood-Group System / Q000097:blood*; D012878:Skin Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System