title: Neuroimaging biomarkers of epileptogenesis.
abstract: Much progress has been made in the field studying the process of epileptogenesis via neuroimaging techniques. Conventional imaging methods include magnetic resonance imaging with morphometric analysis, magnetic resonance spectroscopy and positron emission tomography. Newer network-based methods such as diffusion tensor imaging and functional magnetic resonance imaging with resting functional connectivity are being developed and applied to clinical use. This review provides a brief summary of the major human and animal studies in both partial and generalized epilepsies that demonstrate the potential of these imaging modalities to serve as biomarkers of epileptogenesis.
authors.affiliation: Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. asht.mishra@yale.edu
authors.forename: Asht Mangal
authors.initials: AM
authors.lastname: Mishra
authors.forename: Harrison
authors.initials: H
authors.lastname: Bai
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gribizis
authors.forename: Hal
authors.initials: H
authors.lastname: Blumenfeld
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D015415:Biomarkers; D009419:Nerve Tissue Proteins