title: Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory.
abstract: Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber. Unconditioned suppression of magazine responding to visual stimuli was measured in wild-type and GluA1 knockout mice. Wild-type mice showed less suppression to a stimulus that had been presented recently than to a stimulus that had not. GluA1 knockout mice, however, showed greater suppression to a recent stimulus than to a nonrecent stimulus. Thus, GluA1 is not necessary for encoding, but affects the way that short-term memory is expressed.
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom. david.sanderson@psy.ox.ac.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Sanderson
authors.forename: Rolf
authors.initials: R
authors.lastname: Sprengel
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeburg
authors.forename: David M
authors.initials: DM
authors.lastname: Bannerman
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D003214:Conditioning, Classical / Q000502:physiology*; D005260:Female; D008297:Male; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D010775:Photic Stimulation / Q000379:methods; D018091:Receptors, AMPA / Q000172:deficiency*; D013997:Time Factors
chemical_list: D018091:Receptors, AMPA