title: Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors.
abstract: Transcriptional interference is the in cis suppression of one transcriptional process by another. Mathematical modeling shows that promoter occlusion by elongating RNA polymerases cannot produce strong interference. Interference may instead be generated by (1) dislodgement of slow-to-assemble pre-initiation complexes and transcription factors and (2) prolonged occlusion by paused RNA polymerases.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Palmer
authors.forename: J Barry
authors.initials: JB
authors.lastname: Egan
authors.forename: Keith E
authors.initials: KE
authors.lastname: Shearwin
mesh_terms: D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D014157:Transcription Factors; D012321:DNA-Directed RNA Polymerases