title: Prognostic factors for post-recurrence survival in esophageal squamous cell carcinoma patients with recurrence after resection.
abstract: OBJECTIVE
  The survival of recurrent esophageal cancer is poor. But reports regarding prognostic factors for post-recurrence survival are limited. We analyzed the recurrence pattern and the prognostic factors for post-recurrence survival in esophageal squamous cell carcinoma with recurrence after resection.
  
  
  METHODS
  Two hundred sixty-eight patients were included. Tumor recurrence occurred in 115 (42.9%) patients. Recurrence pattern was classified as locoregional, distant, and combined recurrence. The post-recurrence survival was defined as the interval between initial recurrence and either death or the last follow-up.
  
  
  RESULTS
  Mediastinum lymphadenopathy was the most common site for locoregional recurrence, whereas lung, liver, and bone were the most common sites for distant recurrence. The overall 1- and 2-year post-recurrence survival rates were 32.6% and 12.6% with a median survival after recurrence of 6.0 months. The independent prognostic factors included liver recurrence (HR = 2.255, 95%CI = 1.073-4.741, p = 0.032), time to recurrence ≤10 months (HR = 2.657, 95%CI = 1.438-4.911, p = 0.002), and no treatment for recurrences (HR = 2.745, 95%CI = 1.635-4.608, p < 0.001).
  
  
  CONCLUSIONS
  We identify liver recurrence, early recurrence, and no treatment for recurrence as risk factors for dismal post-recurrence survival.
authors.affiliation: Department of Surgery, Chutung Veterans Hospital, Hsinchu County, Taiwan.
authors.forename: Po-Kuei
authors.initials: PK
authors.lastname: Hsu
authors.forename: Bing-Yen
authors.initials: BY
authors.lastname: Wang
authors.forename: Chien-Sheng
authors.initials: CS
authors.lastname: Huang
authors.forename: Yu-Chung
authors.initials: YC
authors.lastname: Wu
authors.forename: Wen-Hu
authors.initials: WH
authors.lastname: Hsu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000556:secondary* / Q000601:surgery; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D011379:Prognosis; D015996:Survival Rate