title: Effect of sympathomimetic drugs on canine bladder: surgical model for assessment of regional differences.
abstract: A surgical procedure is described in which the canine bladder was divided into body and base. The two-chambered bladder thus formed was used to assess the effect of sympathomimetic drugs in situ. Stimulation of either alpha- or beta-receptors produced a change in pressure in both chambers. The bladder base showed a greater sensitivity to alpha-receptor stimulation than did the body of the bladder. No difference in sensitivity to beta-receptor stimulation was noted between body and base.
authors.affiliation: Department of Urology, Queen's University, Kingston, Ontario, Canada.
authors.forename: J W
authors.initials: JW
authors.lastname: Downie
authors.forename: S A
authors.initials: SA
authors.lastname: Awad
authors.forename: D W
authors.initials: DW
authors.lastname: Lywood
authors.forename: A W
authors.initials: AW
authors.lastname: Bruce
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D023421:Models, Animal; D013566:Sympathomimetics / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000601:surgery; D013520:Urologic Surgical Procedures
chemical_list: D013566:Sympathomimetics