title: Infection, vascularization, remodelling--are stem cells the answers for bone diseases of the jaws?
abstract: Osteonecrosis after craniofacial radiation (ORN), osteomyelitis and bisphosphonates related necrosis of the jaw (BRONJ) are the predominant bone diseases in Cranio- and Maxillofacial surgery. Although various hypothesis for the pathophysiological mechanisms including infection, altered vascularisation or remodelling exist, the treatment is still a challenge for clinicians. As the classical pharmacological or surgical treatment protocols have only limited success, stem cells might be a promising treatment option, indicated by recently published data.
authors.forename: Jörg
authors.initials: J
authors.lastname: Handschel
authors.forename: Ulrich
authors.initials: U
authors.lastname: Meyer
mesh_terms: D000818:Animals; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D007571:Jaw Diseases / Q000209:etiology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation; D051379:Mice; D009389:Neovascularization, Pathologic / Q000628:therapy; D010019:Osteomyelitis / Q000628:therapy*; D010020:Osteonecrosis / Q000209:etiology / Q000628:therapy*
chemical_list: D004164:Diphosphonates