title: A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging.
abstract: A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.
authors.affiliation: Department of Chemistry, Cardiff University, Cardiff, Cymru/Wales, UK CF10 3AT.
authors.forename: Flora L
authors.initials: FL
authors.lastname: Thorp-Greenwood
authors.forename: Vanesa
authors.initials: V
authors.lastname: Fernández-Moreira
authors.forename: Coralie O
authors.initials: CO
authors.lastname: Millet
authors.forename: Catrin F
authors.initials: CF
authors.lastname: Williams
authors.forename: Joanne
authors.initials: J
authors.lastname: Cable
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Court
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Hayes
authors.forename: David
authors.initials: D
authors.lastname: Lloyd
authors.forename: Michael P
authors.initials: MP
authors.lastname: Coogan
mesh_terms: D001692:Biological Transport; D045744:Cell Line, Tumor; D002466:Cell Nucleolus / Q000378:metabolism*; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D049268:Positron-Emission Tomography; D012211:Rhenium / Q000737:chemistry; D012834:Silver / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D005456:Fluorescent Dyes; D007477:Ions; D008670:Metals; D009942:Organometallic Compounds; D012834:Silver; D012211:Rhenium; D003300:Copper