title: 5-HT(6) receptor and cognition.
abstract: Since its discovery in 1993 and subsequent development of selective antagonists, a growing number of studies support the use of serotonin 5-HT(6) receptor antagonism as a promising mechanism for treating cognitive dysfunction. Lately, several studies with structurally different compounds have shown that not only antagonists, but also 5-HT(6) receptor agonists improve learning and memory in animal models. There is even an antagonist, SB-742457, that has completed phase II trials for the treatment of Alzheimer's disease. In addition to describe preclinical and clinical evidence of the effect of 5-HT(6) receptor compounds on cognition, this article will also focus on the purported biochemical and neurochemical mechanisms of action by which 5-HT(6) receptor compounds could influence cognition in health and disease.
authors.affiliation: Laboratorios Dr Esteve SA, Barcelona, Spain.
authors.forename: Xabier
authors.initials: X
authors.lastname: Codony
authors.forename: Jose Miguel
authors.initials: JM
authors.lastname: Vela
authors.forename: Maria Javier
authors.initials: MJ
authors.lastname: Ramírez
mesh_terms: D000818:Animals; D017322:Clinical Trials, Phase II as Topic; D003071:Cognition / Q000187:drug effects* / Q000502:physiology*; D003072:Cognition Disorders / Q000188:drug therapy*; D006801:Humans; D011985:Receptors, Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C097216:serotonin 6 receptor