title: Clinical practice: the treatment of acute convulsive seizures in children.
abstract: An adequate early treatment of a long-lasting convulsive seizure is critical in reducing potential morbidity, and in particular, brain damage. In pre-hospital settings the use of benzodiazepines should become standard. Nowadays, rectal diazepam is used frequently, but midazoloam and lorazepam are becoming more popular, both being given either intranasally or orally. The buccal route is to be preferred because of its easy use and high efficacy. A generally accepted policy for early treatment of convulsive seizures is a crucial issue in the elaboration of an overall treatment plan for the child with epilepsy. Such a plan should include instruction and education of the parents and the caregivers surrounding the child.
authors.affiliation: Department of Paediatric Neurology, University Hospitals KULeuven, Leuven, Belgium. lieven.lagae@uzleuven.be
authors.forename: Lieven
authors.initials: L
authors.lastname: Lagae
mesh_terms: D000208:Acute Disease; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use; D018757:GABA Modulators / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage / Q000627:therapeutic use; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use; D012640:Seizures / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D018757:GABA Modulators; D001569:Benzodiazepines; D008140:Lorazepam; D003975:Diazepam; D008874:Midazolam