title: [A study on the expression of erbB4/HER4 in non-small cell lung cancer].
abstract: BACKGROUND
  To detect the expression of human epidermal-growth-factor receptor 4 (HER4) and elucidate the relationship between its overexpression and the clinicopathological characteristics in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  The expression of HER4 was detected in 70 cases of paraffin-embedded NSCLC tissues by immunohistochemical assay.
  
  
  RESULTS
  HER4 were overexpressed in 91.4% of NSCLC. The overexpression of HER4 was significantly related to lymph node metastasis (P=0.007), TNM stages (P=0.011) and postoperative survival rate (P= 0.0258).
  
  
  CONCLUSIONS
  erbB4 is one of the genes to regulate the growth of advanced NSCLC. The artificial interference with HER4 overexpression may be a good way in the treatment of advanced NSCLC.
authors.affiliation: Respiratory Department, The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315020, P.R.China.
authors.forename: Zaichun
authors.initials: Z
authors.lastname: Deng
authors.forename: Wenying
authors.initials: W
authors.lastname: Yu
authors.forename: Guoping
authors.initials: G
authors.lastname: Hu
authors.forename: Ruheng
authors.initials: R
authors.lastname: Zheng
authors.forename: Dunhua
authors.initials: D
authors.lastname: Zhang
authors.forename: Yunshan
authors.initials: Y
authors.lastname: Tan
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Xu
authors.forename: Wanli
authors.initials: W
authors.lastname: Jiang