title: Variations in 5-HT2A influence spatial cognitive abilities and working memory.
abstract: BACKGROUND
  5-hydroxytryptamine receptor 2A (5-HT2A) participates in diverse psychiatric disorders by regulating the activity of serotonin. Some previous studies have also suggested that the receptor is involved in cognitive abilities of disease groups. We hypothesize that some functional genetic variants in 5-HT2A have certain specific influences on cognitive abilities in a normal population.
  
  
  METHODS
  To confirm this hypothesis, two polymorphisms (rs6313 and rs4941573) in 5-HT2A were selected, and a population-based study was performed in a young healthy Chinese Han cohort.
  
  
  RESULTS
  The results indicated that the rs6313 and rs4941573 were associated with touching blocks and mental rotation-3D error ratio in males, and the rs4941573 was associated with visuo-spatial working memory in the whole cohort.
  
  
  CONCLUSIONS
  All the findings suggest that 5-HT2A participates in human spatial cognitive abilities and spatial working memory.
authors.affiliation: Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Institute of Population and Health Henan University of Science and Technology, Luoyang, China.
authors.forename: Pingyuan
authors.initials: P
authors.lastname: Gong
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Lei
authors.forename: Dongmei
authors.initials: D
authors.lastname: Chen
authors.forename: Kejin
authors.initials: K
authors.lastname: Zhang
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Zhang
authors.forename: Anyuan
authors.initials: A
authors.lastname: Zhen
authors.forename: Xiaocai
authors.initials: X
authors.lastname: Gao
authors.forename: Fuchang
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People; D018672:Community Health Planning; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012737:Sex Factors; D013028:Space Perception / Q000502:physiology*; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A