title: Post-thyroidectomy hypocalcemic syndrome: predictive value of early PTH. Preliminary results.
abstract: OBJECTIVE
  The aim of this study is to determine an early measured serous PTH cut-off value below which it's possible to predict post-thyroidectomy hypocalcaemia outbrake.
  
  
  METHODS
  Ninety-three consecutive patients having a benign thyroid pathology were submitted to total thyroidectomy. In all the patients serous post-surgery intact PTH and total calcium were measured within an hour from weaning. 65 patients were measured a second time 18 hours from surgery. We searched for a correlation between the post-surgery PTH values at 1 and 18 hours from surgery with the calcemia at 1 and 18 hours from surgery. We carried out a one-year follow-up for each patient. Hypocalcemia developed in 26 patients (27.95%). It was transitory in twenty-two patients (23.65%) and permanent in 4 patients (4.3%). No correlation was found between PTH1 and Cal (p = 0.8). Statistically relevant correlation (p = 0.008) was found between PTH1 and Ca2. The correlation between PTH2 and Ca2 (p = 0.001) turns out to be even more relevant. We also calculated a found that 9.5 pg/dl was PTH1 cut-off value below which it is possible to predict hypocalcemia onset (p = 0.001).
  
  
  CONCLUSIONS
  Early post-surgery PTH measuring is a highly predictive test of post-surgery hypocalcemia. We identified a PTH1 cut-off value of 9.5 pg/dl, below which hypocalcemia onset is extremely frequent. This assessment permits us to establish an adequate drug prophylaxis, thus avoiding the related symptoms. We can also perform one-day surgery thyroidectomy in patients showing normal PTH values.
authors.affiliation: Azienda Ospedaliera Universitaria Policlinico G. Rodolico Catania, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Costanzo
authors.forename: Alessia
authors.initials: A
authors.lastname: Marziani
authors.forename: Francesca
authors.initials: F
authors.lastname: Condorelli
authors.forename: Marcello
authors.initials: M
authors.lastname: Migliore
authors.forename: Matteo Angelo
authors.initials: MA
authors.lastname: Cannizzaro
mesh_terms: D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000097:blood* / Q000209:etiology*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D011237:Predictive Value of Tests; D013577:Syndrome; D013965:Thyroidectomy / Q000009:adverse effects*
chemical_list: D010281:Parathyroid Hormone