title: [Confined placental mosaicisms a priori from meiotic origin: analysis of 10 cases].
abstract: This retrospective monocenter study focused on confined placental mosaicisms a priori from meiotic origin (i.e. non-mosaic type 3 confined placental mosaicisms). From a series of 14,967 chorionic villus samplings performed in our Fetal Medicine Center, 10 non-mosaic type 3 confined placental mosaicisms were identified. These abnormalities only involved chromosomes 15, 16 or 22. Pregnancies complicated by these confined placental mosaicisms were associated with prematurity and neonatal hypotrophy. Thus, when a confined placental mosaicism is suspected, this retrospective study highlighted the need to characterize the type of confined placental mosaicism to prevent the probable intra-uterine growth retardation and to adapt the obstetrical monitoring if necessary.
authors.affiliation: Service de gynécologie-obstétrique, maternité Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Labeau-Gaüzere
authors.forename: J
authors.initials: J
authors.lastname: Horovitz
authors.forename: J-L
authors.initials: JL
authors.lastname: Brun
authors.forename: R
authors.initials: R
authors.lastname: Saura
authors.forename: J
authors.initials: J
authors.lastname: Toutain
mesh_terms: D000328:Adult; D015193:Chorionic Villi Sampling; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics; D006801:Humans; D009030:Mosaicism; D010920:Placenta; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics; D012189:Retrospective Studies