title: Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease.
abstract: OBJECTIVE
  An increased mean platelet volume (MPV), as an indicator of larger, more reactive platelets resulting from an increased platelet turnover, may represent a risk factor for overall vascular mortality, including myocardial infarction. We intended to identify patients at higher risk of dying from vascular disease in a large, hospital-based cohort.
  
  
  RESULTS
  A total of 206 554 first-ever admissions to the Allgemeines Krankenhaus Wien for determination of MPV between January 1996 and July 2003 were included. Primary end points were overall vascular mortality and death due to ischemic heart disease. Multivariate Cox regression adjusted for sex, age, and platelet count was applied for analysis. MPV values were categorized into quintiles, with the lowest quintile serving as the reference category. Compared with individuals with lower MPV (<8.7 fL), hazard ratios for overall vascular mortality gradually increased to 1.5 in the highest category (≥11.01 fL). The relationship of MPV to ischemic heart disease was even stronger and increased from 1.2 (8.71 to 9.60 fL category) to 1.8 in the highest category (≥11.01 fL).
  
  
  CONCLUSIONS
  Our results indicate that patients with an increased MPV (≥11.01 fL) are at higher risk of death due to ischemic heart disease, with hazard ratios comparable to those reported for obesity or smoking.
authors.affiliation: Allgemeines Krankenhaus Biobank, Medical University of Vienna, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Allgemeines Krankenhaus Wien, Währinger Gürtel 18-20, 1190 Wien, Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Slavka
authors.forename: Thomas
authors.initials: T
authors.lastname: Perkmann
authors.forename: Helmuth
authors.initials: H
authors.lastname: Haslacher
authors.forename: Stefan
authors.initials: S
authors.lastname: Greisenegger
authors.forename: Claudia
authors.initials: C
authors.lastname: Marsik
authors.forename: Oswald F
authors.initials: OF
authors.lastname: Wagner
authors.forename: Georg
authors.initials: G
authors.lastname: Endler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria / Q000453:epidemiology; D001792:Blood Platelets / Q000473:pathology*; D002423:Cause of Death; D048429:Cell Size; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000401:mortality*; D010343:Patient Admission; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D014652:Vascular Diseases / Q000097:blood* / Q000401:mortality*; D055815:Young Adult