title: Lamin B receptor: multi-tasking at the nuclear envelope.
abstract: Lamin B receptor (LBR) is an integral membrane protein of the interphase nuclear envelope (NE). The N-terminal end resides in the nucleoplasm, binding to lamin B and heterochromatin, with the interactions disrupted during mitosis. The C-terminal end resides within the inner nuclear membrane, retreating with the ER away from condensing chromosomes during mitotic NE breakdown. Some of these properties are interpretable in terms of our current structural knowledge of LBR, but many of the structural features remain unknown. LBR apparently has an evolutionary history which brought together at least two ancient conserved structural domains (i.e., Tudor and sterol reductase). This convergence may have occurred with the emergence of the chordates and echinoderms. It is not clear what survival values have maintained LBR structure during evolution. But it seems likely that roles in post-mitotic nuclear reformation, interphase NE growth and compartmentalization of nuclear architecture might have provided some evolutionary advantage to preservation of the LBR gene.
authors.affiliation: Department of Biology, Bowdoin College, Brunswick, ME, USA.
authors.forename: Ada L
authors.initials: AL
authors.lastname: Olins
authors.forename: Gale
authors.initials: G
authors.lastname: Rhodes
authors.forename: David B Mark
authors.initials: DB
authors.lastname: Welch
authors.forename: Monika
authors.initials: M
authors.lastname: Zwerger
authors.forename: Donald E
authors.initials: DE
authors.lastname: Olins
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D007399:Interphase; D008938:Mitosis; D009685:Nuclear Envelope / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D000097682:Lamin B Receptor
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D000097682:Lamin B Receptor