title: Trisomy 14 as a sole chromosome abnormality is associated with older age, a heterogenous group of myeloid neoplasms with dysplasia, and a wide spectrum of disease progression.
abstract: Trisomy 14 is a rare recurrent cytogenetic abnormality in myeloid neoplasms; however, its clinicopathologic features have not been well described. We report the clinicopathologic, immunophenotypic, and molecular genetic features of 16 cases of myeloid neoplasms with isolated trisomy 14. Our results show that cases with isolated trisomy 14 encompass a heterogeneous group of myeloid neoplasms including myelodysplastic syndrome (MDS, 44%), myelodysplastic/myeloproliferative neoplasms (31%), and acute myeloid leukemia (25%). The patients are usually elder (median age 71 years), and there is a male predominance (82%). Multilineage dysplasia is noted in all cases. Oncogenic mutations of genes involved in cell proliferation and/or survival rarely occur. Compared with cases of MDS with diploid karyotype, patients of MDS with isolated trisomy 14 demonstrate a similar overall survival and rate of leukemia transformation.
authors.affiliation: Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Bouleuard, Houston, TX 77030, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Bueso-Ramos
authors.forename: C Cameron
authors.initials: CC
authors.lastname: Yin
authors.forename: Jianlan
authors.initials: J
authors.lastname: Sun
authors.forename: Su
authors.initials: S
authors.lastname: Chen
authors.forename: Ramya
authors.initials: R
authors.lastname: Muddasani
authors.forename: Gary
authors.initials: G
authors.lastname: Lu
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D048708:Cell Growth Processes / Q000502:physiology; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D004171:Diploidy; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D054437:Myelodysplastic-Myeloproliferative Diseases / Q000235:genetics* / Q000473:pathology; D012737:Sex Factors; D016019:Survival Analysis; D014314:Trisomy / Q000235:genetics / Q000473:pathology