title: DNA damage response in adult stem cells: pathways and consequences.
abstract: In contrast to postmitotic or short-lived somatic cells, tissue-specific stem cells must persist and function throughout life to ensure tissue homeostasis and repair. The enormous functional demands and longevity of stem cells raises the possibility that stem cells might be uniquely equipped to maintain genomic integrity in ways different than somatic cells. Indeed, evidence suggests that stem cell compartments possess unique properties that combine to either limit or, in some instances, accelerate DNA damage accrual.
authors.affiliation: Immune Disease Institute, the Program in Cellular and Molecular Medicine, Childrens Hospital Boston, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Mandal
authors.forename: Cédric
authors.initials: C
authors.lastname: Blanpain
authors.forename: Derrick J
authors.initials: DJ
authors.lastname: Rossi
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism*; D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species