title: Experimental and spectroscopic studies of charge transfer reaction between sulfasalazine antibiotic drug with different types of acceptors.
abstract: The charge-transfer (CT) interactions between the electron donor sulfasalazine (SS) and the acceptors 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), p-chloranil (CHL), picric acid (PA) and iodine have been studied spectrophotometrically in CHCl(3) or CH(3) OH solutions. The formed solid CT complexes were also isolated and characterized through infrared, (1) H-NMR, mass spectra as well as elemental and thermal analysis. The CT complexes were discussed in terms of formation constant (K(CT) ), molar extinction coefficient (ε(CT) ), standard free energy (ΔG°), oscillator strength (f), transition dipole moment (µ), resonance energy (R(N) ) and ionization potential (I(D) ). The stoichiometry of these complexes was found to be 1:1 molar ratio and having the formulae [(SS)(DDQ)], [(SS)(CHL)], [(SS)(PA)] and [(SS)(2) I](+) · I(3) (-) , respectively. The charge transfer interaction was successfully applied to the determination of SS drug using mentioned σ and π-acceptors also, the results obtained herein are satisfactory for estimation of SS compound in the pharmaceutical form.
authors.affiliation: Department of Chemistry, Faculty of Science, Port Said 42111, Port Said University, Egypt. msrefat@yahoo.com
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
authors.forename: Sabry A
authors.initials: SA
authors.lastname: El-Korashy
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: El-Deen
authors.forename: Shaima M
authors.initials: SM
authors.lastname: El-Sayed
mesh_terms: D000465:Algorithms; D016227:Benzoquinones / Q000737:chemistry*; D055598:Chemical Phenomena; D002703:Chloranil / Q000737:chemistry*; D004735:Energy Transfer; D007455:Iodine / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis; D012460:Sulfasalazine / Q000737:chemistry*; D013816:Thermodynamics; D013818:Thermogravimetry
chemical_list: D016227:Benzoquinones; D010851:Picrates; D012997:Solvents; D002703:Chloranil; C000928:dichlorodicyanobenzoquinone; D012460:Sulfasalazine; D007455:Iodine; C005858:picric acid