title: Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Reiner
authors.forename: Edmund J
authors.initials: EJ
authors.lastname: Keliher
authors.forename: Sarah
authors.initials: S
authors.lastname: Earley
authors.forename: Brett
authors.initials: B
authors.lastname: Marinelli
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D034242:Cyclooctanes / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000175:diagnosis; D010793:Phthalazines / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D034242:Cyclooctanes; D004791:Enzyme Inhibitors; D005462:Fluorine Radioisotopes; D010793:Phthalazines; D010879:Piperazines; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D019275:Radiopharmaceuticals; D011065:Poly(ADP-ribose) Polymerases; C531550:olaparib