title: Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis.
abstract: Invadopodia are extracellular matrix (ECM)-degrading protrusions formed by invasive cancer cells. Podosomes are structures functionally similar to invadopodia that are found in oncogene-transformed fibroblasts and monocyte-derived cells, including macrophages and osteoclasts. These structures are thought to play important roles in the pericellular remodeling of ECM during cancer invasion and metastasis. Much effort has been directed toward identification of the molecular components and regulators of invadopodia/podosomes, which could be therapeutic targets in the treatment of malignant cancers. However, it remains largely unknown how these components are assembled into invadopodia/podosomes and how the assembly process is spatially and temporally regulated. This review will summarize recent progress on the molecular mechanisms of invadopodia/podosome formation, with strong emphasis on the roles of lipid rafts and phosphoinositides.
authors.affiliation: Growth Factor Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan.|Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamaguchi
authors.affiliation: Collaborative Research Resources, Institute for Integral Medical Research, School of Medicine, Keio University, Tokyo 160-8582, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Oikawa
mesh_terms: D000818:Animals; D051242:Caveolin 1 / Q000378:metabolism; D022081:Cell Surface Extensions / Q000378:metabolism* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051242:Caveolin 1; D008563:Membrane Lipids; D010716:Phosphatidylinositols; D058539:Phosphatidylinositol 3-Kinase