title: Contrast improvement of terahertz images of thin histopathologic sections.
abstract: We present terahertz images of 10 μm thick histopathologic sections obtained in reflection geometry with a time-domain spectrometer, and demonstrate improved contrast for sections measured in paraffin with water. Automated segmentation is applied to the complex refractive index data to generate clustered terahertz images distinguishing cancer from healthy tissues. The degree of classification of pixels is then evaluated using registered visible microscope images. Principal component analysis and propagation simulations are employed to investigate the origin and the gain of image contrast.
authors.affiliation: Sony Corporation, Life Science Laboratory, Advanced Materials Laboratories, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Florian
authors.initials: F
authors.lastname: Formanek
authors.forename: Marc-Aurèle
authors.initials: MA
authors.lastname: Brun
authors.forename: Akio
authors.initials: A
authors.lastname: Yasuda