title: The toxicokinetics of 2-methylnaphtalene in rats.
abstract: BACKGROUND
  The aim of the study was to evaluate the toxicokinetics of 2-methylnaphtalene (2-MN) during and after inhalation exposure.
  
  
  METHODS
  Male Wistar rats were exposed to 2-MN vapours at nominal concentrations of 200 or 400 mg/m3 in the dynamic inhalation chamber for 6 hours or 5 days (6 h/day). Blood samples were collected during and after exposure. Blood concentrations of 2-MN were estimated by gas chromatography using the headspace technique.
  
  
  RESULTS
  During a 6-hour exposure to 200 or 400 mg/m3, blood 2-MN concentration increased rapidly within the first or second hour of exposure, respectively, after reaching a plateau. The elimination of 2-MN from blood followed an open two-compartment model.
  
  
  CONCLUSIONS
  2-MN was rapidly eliminated from blood of the animals exposed by inhalation to 2-MN. During exposure, lung retention of the chemical was found to decrease. Under conditions of repeated 2-MN exposure, no significant systemic 2-MN accumulation could be observed.
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Łódź, Poland. radek@imp.lodz.pl
authors.forename: Radosław
authors.initials: R
authors.lastname: Swiercz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wąsowicz
authors.forename: Wanda
authors.initials: W
authors.lastname: Majcherek
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D055370:Lung Injury / Q000139:chemically induced; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004785:Environmental Pollutants; D009281:Naphthalenes; C027384:2-methylnaphthalene