title: 5-oxo-15-HETE: total synthesis and bioactivity.
abstract: The first total synthesis of 6(E),8(Z),11(Z),13(E) 5-oxo-15-HETE 4 was accomplished. The synthetic material was evaluated with calcium mobilization assay and compared with 5-oxo-ETE the natural ligand for the OXE receptor.
authors.affiliation: Claude Pepper Institute, Florida Institute of Technology, Melbourne, FL 32901, USA.
authors.forename: Pranav
authors.initials: P
authors.lastname: Patel
authors.forename: Jaganmohan R
authors.initials: JR
authors.lastname: Anumolu
authors.forename: William S
authors.initials: WS
authors.lastname: Powell
authors.forename: Joshua
authors.initials: J
authors.lastname: Rokach
mesh_terms: D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D009504:Neutrophils / Q000187:drug effects; D018055:Receptors, Eicosanoid / Q000187:drug effects
chemical_list: D006893:Hydroxyeicosatetraenoic Acids; D008024:Ligands; C504018:OXER1 protein, human; D018055:Receptors, Eicosanoid; C075441:5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid