title: [Advanced glycation end-products: new markers of renal dysfunction in patients with chronic heart failure].
abstract: OBJECTIVE
  Advanced glycation end-products (AGE) are implicated in the physiopathology and prognosis of heart failure (HF) and they accumulate in situations such as kidney failure (KF). Our objective was to analyze the relation between AGE and KF in patients with chronic HF.
  
  
  METHODS
  102 consecutive patients of our medical center were included. Clinical and analytical data were obtained, with measurement of glycated haemoglobin, brain natriuretic peptide, cystatin C and fluorescent AGE. Glomerular filtration rate (GFR) was estimated for each patient.
  
  
  RESULTS
  40.2% of patients presented GFR < 60 mL/min/1.73 m(2) and 11.7% had hidden kidney disease (HKD). AGE correlated positively with creatinine (r=0.685, p<0.001) and cystatin C (r=0.682, p<0.001) and negatively with GFR (r=-0.720, p<0.001). Medium value of fluorescent AGE in patients with KF was higher than those without KF (83.4 [3.3] URF vs 56.8 [2.1] URF, p<0.001). With regard to the diagnostic value for HKD, fluorescent AGE presented an area under the ROC curve higher than other parameters for KD such as cystatin C. In the multivariate analysis, fluorescent AGE were an independent biomarker of KD (OR 1.060; 95% CI 1.024-1.097; p=0.001).
  
  
  CONCLUSIONS
  AGE act as a biomarker of KD in patients with chronic HF, both diabetics and non diabetics, being better than cystatin C in the detection of HKD.
authors.affiliation: Servicio de Cardiología, Hospital Clínico Universitario de Santiago de Compostela, España.
authors.forename: Sergio
authors.initials: S
authors.lastname: Raposeiras-Roubín
authors.forename: Bruno K
authors.initials: BK
authors.lastname: Rodiño-Janeiro
authors.forename: Lilian
authors.initials: L
authors.lastname: Grigorian-Shamagian
authors.forename: María
authors.initials: M
authors.lastname: Moure-González
authors.forename: Ana
authors.initials: A
authors.lastname: Seoane-Blanco
authors.forename: Alfonso
authors.initials: A
authors.lastname: Varela-Román
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Alvarez
authors.forename: José R
authors.initials: JR
authors.lastname: González-Juanatey
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005919:Glomerular Filtration Rate; D017127:Glycation End Products, Advanced / Q000097:blood*; D006333:Heart Failure / Q000097:blood* / Q000150:complications*; D006801:Humans; D008297:Male; D051437:Renal Insufficiency / Q000097:blood* / Q000150:complications* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced