title: A catalytic route to ampakines and their derivatives.
abstract: A catalytic domino reaction that efficiently provides access to an important class of heterocycles, the ampakines, is reported. Our approach is based on the cobalt-catalyzed hydroformylation of dihydrooxazines and allows for the facile synthesis of the pharmaceutically interesting compound CX-614 and related substances.
authors.affiliation: Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Mulzer
authors.forename: Geoffrey W
authors.initials: GW
authors.lastname: Coates
mesh_terms: D002384:Catalysis; D003035:Cobalt / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D018697:Nootropic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010078:Oxazines / Q000737:chemistry*
chemical_list: D018697:Nootropic Agents; D010078:Oxazines; D003035:Cobalt