title: Antidyslipidemic activity of hot-water extracts from leaves of Cinnamomum osmophloeum Kaneh.
abstract: The antidyslipidemic activity of hot-water extracts of Cinnamomum osmophloeum leaves (COE) were evaluated on hamsters fed a high-fat diet. Oral administration of COE to hyperlipidemic hamsters reduced the total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL-C) levels. Compared with hyperlipidemic hamsters, the plasma TC and TG levels of hamsters fed with COE at a dosage of 100 mg/kg body weight for 5 and 10 weeks were significantly reduced to 12.63% and 34.25%, and 33.88% and 36.88%, respectively. Plasma LDL-C was also reduced to 27.77% after 10 weeks feeding with the same regimen. Standard diagnostic tests indicated that the extracts did not cause damage to hamster liver or kidneys. Based on these results, it is concluded that COE possesses antidyslipidemic activity. The composition of COE was characterized. Two main compounds, kaempferol 3-O-β-D-apiofuranosyl-(1 → 2)-α-L-arabinofuranosyl-7-O-α-L-rhamnopyranoside (1) and kaempferitrin (2) were identified in the hot-water extracts. Their contents were 7.56% and 9.95%, respectively.
authors.affiliation: Core Laboratory of Plant Metabolomics, Biotechnology Center and Department of Forestry, National Chung Hsing University, Kou Kung Road, Taichung, 402, Taiwan.
authors.forename: Ting-Yu
authors.initials: TY
authors.lastname: Lin
authors.forename: Jiunn-Wang
authors.initials: JW
authors.lastname: Liao
authors.forename: Shang-Tzen
authors.initials: ST
authors.lastname: Chang
authors.forename: Sheng-Yang
authors.initials: SY
authors.lastname: Wang
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D027424:Cinnamomum / Q000737:chemistry*; D006224:Cricetinae; D059305:Diet, High-Fat; D004187:Disaccharides / Q000302:isolation & purification; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D044949:Kaempferols / Q000302:isolation & purification; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D004187:Disaccharides; D000960:Hypolipidemic Agents; D044949:Kaempferols; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D014280:Triglycerides; C542487:kaempferol-3-O-(2'-acetyl)arabinofuranosyl-7-O-1-rhamnopyranoside; D002784:Cholesterol; C042728:lespenefril