title: [Efficacy and safety of imidafenacin in female patients with urge and mixed urinary incontinence].
abstract: The effect of imidafenacin for the treatment of overactive bladder (OAB), in female patients with urge and mixed urinary incontinence was examined. Prior to administration and at 1, 2, 3, 4, 6, 8, 10 and 12 weeks after administration, symptoms and quality of life were assessed using the overactive bladder symptom score (OABSS) and the international consultation on incontinence questionnaire-short form (ICIQ-SF), respectively. After administration, OABSS and ICIQ-SF scores were improved significantly when compared to baseline values. The incidence of adverse events was 7. 9% and none were serious. Imidafenacin was effective in female patients with urge and mixed urinary incontinence. In addition, imidafenacin rapidly improved incontinence one week after administration.
authors.affiliation: The Department of Urology, Showa University, Northern Yokohama Hospital.
authors.forename: Makoto
authors.initials: M
authors.lastname: Shimada
authors.forename: Katsuki
authors.initials: K
authors.lastname: Inoue
authors.forename: Taisuke
authors.initials: T
authors.lastname: Okumura
authors.forename: Shiho
authors.initials: S
authors.lastname: Aoki
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsubara
authors.forename: Tomoko
authors.initials: T
authors.lastname: Maeda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Haruaki
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D011788:Quality of Life; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*; D014549:Urinary Incontinence / Q000188:drug therapy*; D053202:Urinary Incontinence, Urge / Q000188:drug therapy*
chemical_list: D018680:Cholinergic Antagonists; D007093:Imidazoles; C120953:imidafenacin