title: Risk and response adapted therapy for early stage Hodgkin lymphoma: a prospective multicenter study of the Australasian Leukaemia and Lymphoma Group/Trans-Tasman Radiation Oncology Group.
abstract: In this prospective, multicenter, non-randomized study for patients with stage I-II Hodgkin lymphoma, group 1 (without risk-factors [RF]) had three cycles of ABVD chemotherapy (adriamycin, bleomycin, vinblastine, and dacarbazine) and group 2 (any of bulk, extranodal site, >3 regions, raised erythrocyte sedimentation rate [ESR]) and group 3 (B-symptoms) received four cycles. Involved field radiotherapy (IFRT) 30 Gy was given after adequate chemotherapy response. Five-year overall survival and freedom from progression (FFP) were 96% (95% confidence interval [CI] 91-98%) and 90% (84-94%), respectively. Five-year FFP was 97% (90-99%), 89% (75-95%), and 73% (52-86%) for groups 1, 2, and 3, respectively. In patients with RF, chemotherapy responses of complete response unconfirmed (CRu), partial response (PR), and stable disease (SD) were associated with FFP of 90%, 86%, and 62% (p=0.17), and CR/no CR on functional imaging with FFP of 90%/67%, respectively (p=0.05). The 97% FFP in group 1 compares favorably with previously reported results from cooperative trial groups. Intensification of therapy warrants study in patients with RF and a poor chemotherapy response.
authors.affiliation: Department of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, Australia. andrew.wirth@petermac.org
authors.forename: Andrew
authors.initials: A
authors.lastname: Wirth
authors.forename: Andrew
authors.initials: A
authors.lastname: Grigg
authors.forename: Max
authors.initials: M
authors.lastname: Wolf
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.forename: Carol
authors.initials: C
authors.lastname: Johnson
authors.forename: Sidney
authors.initials: S
authors.lastname: Davis
authors.forename: Gaelle
authors.initials: G
authors.lastname: Dutu
authors.forename: Poppy
authors.initials: P
authors.lastname: Kypreos
authors.forename: Carole
authors.initials: C
authors.lastname: Smith
authors.forename: Andrew
authors.initials: A
authors.lastname: Kneebone
authors.forename: Mark
authors.initials: M
authors.lastname: Herzberg
authors.forename: David
authors.initials: D
authors.lastname: Joseph
authors.forename: John
authors.initials: J
authors.lastname: Catalano
authors.forename: Daniel
authors.initials: D
authors.lastname: Roos
authors.forename: Janey
authors.initials: J
authors.lastname: Stone
authors.forename: John
authors.initials: J
authors.lastname: Reynolds
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011878:Radiotherapy; D012074:Remission Induction; D018570:Risk Assessment; D016019:Survival Analysis