title: Pharmacological interventions to attenuate the expansion of abdominal aortic aneurysm (AAA) - a systematic review.
abstract: BACKGROUND
  Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms?
  
  
  METHODS
  An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate.
  
  
  RESULTS
  Of an original 450 articles, 21 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1069 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated.
  
  
  CONCLUSIONS
  Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture.
authors.affiliation: Department of Surgical Sciences, Section of Surgery, Uppsala University Hospital, SE 751 85 Uppsala, Sweden. david.bergqvist@surgsci.uu.se
authors.forename: D
authors.initials: D
authors.lastname: Bergqvist
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017544:Aortic Aneurysm, Abdominal / Q000188:drug therapy*; D001019:Aortic Rupture / Q000517:prevention & control*; D018450:Disease Progression; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors