title: Association of circulating levels of leptin and adiponectin with metabolic syndrome and coronary heart disease in patients with various coronary risk factors.
abstract: The aim of this study was to investigate the associations of adiponectin and leptin with metabolic syndrome (MetS) and coronary heart disease (CHD) in patients with various coronary risk factors. We determined serum adiponectin, leptin, and metabolic syndrome components in 104 patients (59 men and 45 women; aged 40-86 years) with various coronary risk factors at a cardiovascular out-patient clinic. Natural logarithmic transformed (ln) leptin was lower in men and smokers, and positively correlated with body mass index (BMI) (r = 0.59, P < 0.0001), waist circumference (r = 0.60, P < 0.0001), and homeostasis model assessment of insulin resistance (HOMA-IR) levels (r = 0.24, P < 0.02). Ln adiponectin was higher in women and nonsmokers, and was correlated with age and high-density lipoprotein cholesterol (HDL-C). Patients with MetS (n = 69) had significantly higher BMI, HOMA-IR, and ln leptin and lower ln adiponectin than those without Mets (Ln leptin, 2.14 ± 0.08 versus 1.30 ± 0.11; Ln adiponectin, 2.29 ± 0.06 versus 2.54 ± 0.09). In contrast, patients with coronary heart disease (CHD: n = 40) had significantly lower serum ln adiponectin concentrations than non-CHD patients (n = 64) (1.79 ± 0.12 versus 1.91 ± 0.10) as well as lower HDL-C and a higher smoking percentage. Consistent results were obtained by multivariate analyses. In conclusion, this study disclosed factors associated with the increase in serum leptin and adiponectin. Serum levels of leptin may be associated positively with MetS, whereas adiponectin levels are associated negatively with MetS and CHD, even in patients with various coronary risk factors.
authors.affiliation: Department of Cardiovascular Medicine, National Hospital Organization Fukuyama Medical Center, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kajikawa
authors.forename: Masae
authors.initials: M
authors.lastname: Ikeda
authors.forename: Shunji
authors.initials: S
authors.lastname: Takemoto
authors.forename: Jun
authors.initials: J
authors.lastname: Tomoda
authors.forename: Natsuki
authors.initials: N
authors.lastname: Ohmaru
authors.forename: Shozo
authors.initials: S
authors.lastname: Kusachi
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008875:Middle Aged; D015999:Multivariate Analysis; D010045:Outpatients; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin