title: NEDD8 pathways in cancer, Sine Quibus Non.
abstract: There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have been identified to conjugate to substrates in a manner analogous to ubiquitin. NEDD8 is one of the most studied UBLs and shares the highest amino acid similarity to ubiquitin. Here, we review the current knowledge of the NEDD8 conjugation cascade derived from functional studies in genetic model organisms, structural insights from crystallographic studies, biochemical studies identifying a growing list of NEDD8 substrates with oncogenic implications, and attempts to pharmacologically target the NEDD8 pathway in cancer.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Watson
authors.forename: Meredith S
authors.initials: MS
authors.lastname: Irwin
authors.forename: Michael
authors.initials: M
authors.lastname: Ohh
mesh_terms: D016147:Genes, Tumor Suppressor; D006801:Humans; D000075687:NEDD8 Protein; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism*
chemical_list: D000075687:NEDD8 Protein; C082860:NEDD8 protein, human; D009363:Neoplasm Proteins; D025801:Ubiquitin; D014452:Ubiquitins