title: Factors affecting recurrence and disease-free survival in granulosa cell tumors of the ovary.
abstract: OBJECTIVE
  To determine risk factors for prognosis and recurrence in ovarian adult-type granulosa cell tumor (GCT).
  
  
  METHODS
  A retrospective review of GCT cases treated at our university hospital between 1991-2006.
  
  
  RESULTS
  Of 39 patients with GCT, 82% had Stage I disease. The median follow-up period was 71 months. There were 12 cases of recurrence (30.8%) and seven of them had died of disease. The pelvis and liver were the most common sites of recurrence (8 and 3 patients, respectively). Interestingly lymph node recurrence was encountered in two patients. Estimated disease-free survival for five years was 82%. Stage and presence of residual tumor were calculated to be the only associated risk factors for recurrence and prognosis (p < 0.05).
  
  
  CONCLUSIONS
  Recurrences in GCT might be associated with stage and presence of residual tumor during primary surgery. Although rarely present during diagnosis, lymph node metastasis might be more common in recurrent disease.
authors.affiliation: Department of Obstetrics and Gynaecology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. cemiyi@yahoo.com
authors.forename: A C
authors.initials: AC
authors.lastname: Iyibozkurt
authors.forename: S
authors.initials: S
authors.lastname: Topuz
authors.forename: F
authors.initials: F
authors.lastname: Gungor
authors.forename: S E
authors.initials: SE
authors.lastname: Akhan
authors.forename: F
authors.initials: F
authors.lastname: Demirci
authors.forename: Y
authors.initials: Y
authors.lastname: Salihoglu
authors.forename: S
authors.initials: S
authors.lastname: Berkman
authors.forename: E
authors.initials: E
authors.lastname: Bengisu
mesh_terms: D000328:Adult; D000367:Age Factors; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006106:Granulosa Cell Tumor / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000556:secondary; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*; D010386:Pelvic Neoplasms / Q000453:epidemiology / Q000556:secondary; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey; D016387:Women's Health; D055815:Young Adult