title: Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components.
abstract: This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. Their potential applications for the treatment of endotoxaemia, obesity, diabetes, Alzheimer's disease and their uses as cardiovascular and gastrointestinal protective agents, analgesics, anti-oxidant, anti-atherosclerosis agents, dermatological agents and anti-infectious agents are highlighted. Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components.
authors.affiliation: Institute of Pharmacology, National Yang-Ming University, No 155, Sec 2, Linong Road, Taipei 112, Taiwan. chiehfuchen@gmail.com.
authors.forename: Jyh-Fei
authors.initials: JF
authors.lastname: Liao
authors.forename: Wen-Fei
authors.initials: WF
authors.lastname: Chiou
authors.forename: Yuh-Chiang
authors.initials: YC
authors.lastname: Shen
authors.forename: Guei-Jane
authors.initials: GJ
authors.lastname: Wang
authors.forename: Chieh-Fu
authors.initials: CF
authors.lastname: Chen