title: Magnetic resonance spectroscopy of the anterior cingulate cortex in eating disorders.
abstract: The anterior cingulate cortex plays a key role in eating disorders (ED), but it remains an open question whether there are deviations of the neurochemistry of this region in patients with ED. Seventeen adult female patients with ED (10 with bulimia nervosa, 7 with anorexia nervosa) were compared to 14 matched female healthy controls using single voxel magnetic resonance spectroscopy of the anterior cingulate cortex. Group comparisons did not reveal any differences between patients and controls, but a positive correlation between glutamate and myo-inositol signals with "drive for thinness" in patients with bulimia nervosa was found in exploratory correlation analyses.
authors.affiliation: University of Freiburg, Department of Psychosomatic Medicine and Psychotherapy, Freiburg, Germany. andreas.joos@uniklinik-freiburg.de
authors.forename: Andreas A B
authors.initials: AA
authors.lastname: Joos
authors.forename: Evgeniy
authors.initials: E
authors.lastname: Perlov
authors.forename: Martin
authors.initials: M
authors.lastname: Büchert
authors.forename: Armin
authors.initials: A
authors.lastname: Hartmann
authors.forename: Barbara
authors.initials: B
authors.lastname: Saum
authors.forename: Volkmar
authors.initials: V
authors.lastname: Glauche
authors.forename: Tobias
authors.initials: T
authors.lastname: Freyer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weber-Fahr
authors.forename: Almut
authors.initials: A
authors.lastname: Zeeck
authors.forename: Ludger
authors.initials: L
authors.lastname: Tebartz van Elst
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D001068:Feeding and Eating Disorders / Q000473:pathology*; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline