title: Ovarian cancer stem cells and inflammation.
abstract: Epithelial ovarian cancer (EOC) is the fourth leading cause of cancer-related deaths in women in the United States and the leading cause of gynecologic cancer deaths. The major limiting factor in the treatment of ovarian cancer is recurrence and chemoresistance. Individuals who succumb to advanced-stage ovarian cancer inevitably become refractory to chemotherapy, resulting in disease progression and death. The source of recurrence and lack of response to chemotherapy is unknown. The focus of this review is to evaluate the question of recurrence and chemoresistance based on the concept of the cancer stem cells and inflammation.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA. gil.mor@yale.edu
authors.forename: Gil
authors.initials: G
authors.lastname: Mor
authors.forename: Gang
authors.initials: G
authors.lastname: Yin
authors.forename: Ilana
authors.initials: I
authors.lastname: Chefetz
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Ayesha
authors.initials: A
authors.lastname: Alvero
mesh_terms: D000818:Animals; D000077216:Carcinoma, Ovarian Epithelial; D002454:Cell Differentiation / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D016328:NF-kappa B / Q000378:metabolism; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D051193:Toll-Like Receptors