title: High-density lipoprotein levels and 10-year cardiovascular risk in HIV-1-infected patients.
abstract: We aimed to determine the contribution of high-density lipoprotein cholesterol (HDL-c) to cardiovascular disease (CVD) risk in a cohort of HIV-infected patients. The contribution of CVD risk factors to the predicted CVD risk was assessed. We estimated the degree of reclassification of CVD risk if HDL-c concentration was increased in all patients by 20 and 40%, respectively. After age, HDL-c contributed most to the overall cardiovascular risk. Increasing HDL-c by 20% and 40% reclassified six and 12 patients to lower CVD risk groups, respectively. In this cohort, HDL-c contributed more to cardiovascular risk than smoking, total cholesterol, systolic blood pressure (SBP) and sex.
authors.affiliation: HIV Molecular Research Group, School of Medicine and Medical Science, University College Dublin, Ireland. aoife.cotter@ucdconnect.ie
authors.forename: Aoife G
authors.initials: AG
authors.lastname: Cotter
authors.forename: Claudette S
authors.initials: CS
authors.lastname: Satchell
authors.forename: Jane A
authors.initials: JA
authors.lastname: O'halloran
authors.forename: Eoin R
authors.initials: ER
authors.lastname: Feeney
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Sabin
authors.forename: Patrick W G
authors.initials: PW
authors.lastname: Mallon
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000821:virology; D008076:Cholesterol, HDL / Q000378:metabolism*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000378:metabolism*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL