title: [Effect of beta-carotene and carotene producing yeast Phaffia rhodozyma on oxidative stress in rats treated with tetrachloromethane].
abstract: Supplementation of rats' diet with beta-carotene or biomass of carotene producing yeast Phaffia rhodozyma caused a decrease of aminotransferases in the blood serum as well as a decrease of lipid peroxidation products and protein carbonil groups in the liver, brain and myocardium tissues of animals treated with tetrachloromethane. When compared to the control group the activity of superoxide dismutase, catalase and glutathione peroxidase in the liver of carotene fed rats were respectively 1.6, 2.2, and 1.5-fold higher. Thus, these supplements to standard diet slow down development of tetrachlorometane mediated oxidative stress in rats.
authors.forename: M I
authors.initials: MI
authors.lastname: Simonova
authors.forename: N I
authors.initials: NI
authors.lastname: Borets'ka
authors.forename: M V
authors.initials: MV
authors.lastname: Kamins'ka
authors.forename: H I
authors.initials: HI
authors.lastname: Nechaĭ
authors.forename: H V
authors.initials: HV
authors.lastname: Kolisnyk
authors.forename: V V
authors.initials: VV
authors.lastname: Vlizlo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D000637:Transaminases / Q000097:blood; D014815:Vitamins / Q000097:blood; D015003:Yeasts / Q000378:metabolism*; D019207:beta Carotene / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D014815:Vitamins; D019207:beta Carotene; D002251:Carbon Tetrachloride; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000637:Transaminases