title: New nanosized technologies for dermal and transdermal drug delivery. A review.
abstract: Nanocarriers are promising dermal and transdermal drug delivery systems. The review recapitulates the most prominent nanocarriers such as microemulsions, liposomes and micro- and nanoparticles for the dermal and transdermal application. Microemulsions have a high solubilization capacity even for poorly soluble drugs and combined with their permeation enhancing effect high flux rates can be obtained. Liposomal carrier systems exhibit a high flexibility and mobility, whereas the follicular penetration of micro- and nanoparticular systems show an increase in the penetration depth. However, it is necessary to understand the particular mechanism of each transport system in order to limit undesired effects.
authors.affiliation: Martin Luther University Halle-Wittenberg, Halle 06120, Germany.
authors.forename: Annett
authors.initials: A
authors.lastname: Schroeter
authors.forename: Tanja
authors.initials: T
authors.lastname: Engelbrecht
authors.forename: Reinhard H H
authors.initials: RH
authors.lastname: Neubert
authors.forename: Alexandra S B
authors.initials: AS
authors.lastname: Goebel
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004058:Diffusion; D004337:Drug Carriers / Q000138:chemical synthesis*; D006801:Humans; D053769:Nanocapsules / Q000737:chemistry*; D050997:Nanomedicine / Q000379:methods*; D012867:Skin / Q000737:chemistry*; D012869:Skin Absorption
chemical_list: D004337:Drug Carriers; D053769:Nanocapsules