title: Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method.
abstract: OBJECTIVE
  We aimed to measure the levels of total antioxidant status (TAS) in placental samples from preeclamptic pregnant women and evaluate the relation of placental TAS, total oxidant status (TOS) and oxidative stress index (OSI) with fetomaternal compartments using the more recently designated Erel method.
  
  
  METHODS
  Thirty four preeclamptic and 27 normotensive pregnant women were enrolled in this prospective controlled study. Subjects were selected from women attending the Obstetrics and Gynecology Department of Gaziantep University. TAS, TOS, OSI were measured from placental, maternal and cord blood samples using a novel automated method. Statistical analyses were performed with SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA).
  
  
  RESULTS
  The TAS level of the placenta was evaluated as significantly lower (P<0.001) in preeclamptic women compared to normotensive women. In preeclamptic pregnancies, while the placental TAS level was not correlated with placental TOS level, the TAS levels of maternal plasma (P<0.001; r=0.584) and cord plasma (P<0.005; r=0.529) were significantly correlated with the TOS level of the placenta.
  
  
  CONCLUSIONS
  Our results support the concept that placental defective response to an oxidant stimulus plays a central role in the etiopathogenesis of preeclampsia by using the novel automated Erel method.
authors.affiliation: Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, Turkey. ebruozturkarslan@yahoo.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Ozturk
authors.forename: Ozcan
authors.initials: O
authors.lastname: Balat
authors.forename: Yurdanur Gurcay
authors.initials: YG
authors.lastname: Acılmıs
authors.forename: Caglayan
authors.initials: C
authors.lastname: Ozcan
authors.forename: Sadrettin
authors.initials: S
authors.lastname: Pence
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Erel
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D006801:Humans; D018384:Oxidative Stress; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000975:Antioxidants