title: Adenocarcinoma of the nasal cavity and paranasal sinuses: single-institution review of diagnosis, histology, and outcome.
abstract: OBJECTIVE
  To study the incidence, treatment, and outcomes of adenocarcinomas of the nose and paranasal sinuses over the last 15 years.
  
  
  METHODS
  Retrospective chart review of 20 patients identified and treated at the otolaryngology clinic of Zurich University Hospital between 1992 and 2007.
  
  
  METHODS
  Recurrence- and disease-free survival were the most important outcomes of interest.
  
  
  RESULTS
  Twenty patients (16 men) with sinonasal adenocarcinoma were found. The average age was 64 years. At the time of diagnosis, usually more than one sinus was involved and nasal obstruction was the most common symptom. In 57.9% of patients, the initial treatment was endoscopic surgery. Two-year recurrence-free survival was 48.5%, and 5-year disease-specific survival was 77.8%.
  
  
  CONCLUSIONS
  Surgical resection is difficult owing to anatomic restraints, and adjuvant therapy must be considered in most patients. Endoscopic surgery was performed in a majority of patients, with outcomes comparable to those in the general literature.
  
  
  CONCLUSIONS
  Adenocarcinoma of the paranasal sinuses was found to have almost 80% 5-year survival if adequately treated surgically and with adjuvant intensity-modulated radiotherapy.
authors.affiliation: Department of Otorhinolaryngology–Head and Neck Surgery,University Hospital Zurich, Frauenklinikstrasse 24, Zurich,Switzerland. gerry.huber@usz.ch
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Huber
authors.forename: Carole
authors.initials: C
authors.lastname: Gengler
authors.forename: Christiane
authors.initials: C
authors.lastname: Walter
authors.forename: Thomas
authors.initials: T
authors.lastname: Roth
authors.forename: Alexander
authors.initials: A
authors.lastname: Huber
authors.forename: David
authors.initials: D
authors.lastname: Holzmann
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate; D013557:Switzerland / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult