title: The human cytomegalovirus TRL11/IRL11-encoded FcγR binds differentially to allelic variants of immunoglobulin G1.
abstract: Human cytomegalovirus (HCMV) has evolved several immune-evasion strategies. One strategy involves encoding Fcgamma receptor (FcγR)-like proteins that thwart the Fcγ-mediated effector functions. Our aim was to determine whether GM allotypes-immunoglobulin γ chain determinants expressed primarily on the Fc segment-modulate this viral strategy through differential binding to the viral FcγR. Results of our ELISA binding studies show that the mean absorbance values for binding to the HCMV TRL11/IRL11-encoded FcγR were higher for IgG1 expressing the GM 3 allotype than for those expressing the allelic GM 1,2,17 determinants (p = 0.0005), a finding with potential implications for genetic etiology of HCMV-associated diseases.
authors.affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, 29425-2230, USA.
authors.forename: Aryan M
authors.initials: AM
authors.lastname: Namboodiri
authors.forename: Janardan P
authors.initials: JP
authors.lastname: Pandey
mesh_terms: D003587:Cytomegalovirus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011485:Protein Binding; D017452:Receptors, IgG / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; D017452:Receptors, IgG; C464820:UL119-UL118 glycoprotein, Human cytomegalovirus; D014764:Viral Proteins