title: Peppermint oil decreases the production of virulence-associated exoproteins by Staphylococcus aureus.
abstract: The present study aimed to evaluate the antimicrobial activity of peppermint oil against Staphylococcus aureus, and further investigate the influence of peppermint oil on S. aureus virulence-related exoprotein production. The data show that peppermint oil, which contained high contents of menthone, isomenthone, neomenthol, menthol, and menthyl acetate, was active against S. aureus with minimal inhibitory concentrations (MICs) ranging from 64-256 µg/mL, and the production of S. aureus exotoxins was decreased by subinhibitory concentrations of peppermint oil in a dose-dependent manner. The findings suggest that peppermint oil may potentially be used to aid in the treatment of S. aureus infections.
authors.affiliation: Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China. lijing5221@126.com
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Jia-Zhang
authors.initials: JZ
authors.lastname: Qiu
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Ming-Jing
authors.initials: MJ
authors.lastname: Luo
authors.forename: Hong-En
authors.initials: HE
authors.lastname: Li
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Leng
authors.forename: Wen-Zhi
authors.initials: WZ
authors.lastname: Ren
authors.forename: Xu-Ming
authors.initials: XM
authors.lastname: Deng
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology / Q000627:therapeutic use; D005098:Exotoxins / Q000235:genetics / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006461:Hemolysis / Q000187:drug effects; D036142:Mentha piperita; D008826:Microbial Sensitivity Tests; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism* / Q000472:pathogenicity; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000932:Antiemetics; D005098:Exotoxins; D010938:Plant Oils; C015424:peppermint oil