title: A copper(I) isonitrile complex as a heterogeneous catalyst for azide-alkyne cycloaddition in water.
abstract: A structurally well-defined copper(I) isonitrile complex is shown to be an efficient, heterogeneous catalyst for the Huisgen azide-alkyne 1,3-dipolar cycloaddition under mild conditions in water. Notably, this catalyst can also be utilized in a three-component reaction of halides, sodium azide and alkynes to form 1,4-disubstituted 1,2,3-triazoles in high yields. Furthermore, it can be readily recovered by precipitation and filtration and recycled for at least five runs without significant loss of activity.
authors.affiliation: Institut für Organische Chemie, Universität Regensburg, Regensburg, Germany.
authors.forename: Meina
authors.initials: M
authors.lastname: Liu
authors.forename: Oliver
authors.initials: O
authors.lastname: Reiser