title: Hypoxia-inducible factor-1 alpha C1772T gene polymorphism and glioma risk: a hospital-based case-control study from China.
abstract: BACKGROUND
  The hypoxia-inducible factor 1 alpha (HIF-1α) plays a major role in cancer progression.
  
  
  OBJECTIVE
  The aim of this study was to investigate the potential association between HIF-1α C1772T gene polymorphism and glioma risk.
  
  
  METHODS
  We conducted a hospital-based case-control study from China. A total of 300 subjects (150 glioma patients and 150 healthy controls) were recruited in this study. The peripheral blood samples were extracted. The polymerase chain reaction-restriction fragment length polymorphism method was used to test genotypes.
  
  
  RESULTS
  Glioma patients had a significantly lower frequency of CC genotype (odds ratio [OR] = 0.46, 95% confidence interval [CI] = 0.24, 0.91; p = 0.03) and C allele (OR = 0.49, 95% CI = 0.26, 0.91; p = 0.03) than controls. Glioma patients had a significantly higher frequency of CT genotype (OR = 2.13, 95% CI = 1.07, 4.25; p = 0.03) and T allele (OR = 2.05, 95% CI = 1.09, 3.83; p = 0.03) than controls. There were no significant differences in the distributions of HIF-1α C1772T gene polymorphism among glioma patients at different tumor type and stage.
  
  
  CONCLUSIONS
  This study suggested that CT genotype and the T allele of HIF-1α C1772T gene polymorphism were associated with a higher glioma risk in the Han population of China.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, 277 Yanta West Road, Xi’an, China. xgf72@hotmail.com
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Xu
authors.forename: Maode
authors.initials: M
authors.lastname: Wang
authors.forename: Wanfu
authors.initials: W
authors.lastname: Xie
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Bai
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005910:Glioma / Q000235:genetics*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit