title: Weight-reducing effect of Acer truncatum Bunge may be related to the inhibition of fatty acid synthase.
abstract: In order to study the anti-obesity ability and inhibition towards fatty acid synthase (FAS) of the extract, a 70% ethanol extract of Acer truncatum Bunge (AT) leaves was further extracted with ethyl acetate. FAS is a very significant lipogenic enzyme, participating in energy metabolism in vivo; it has also been observed that FAS inhibitors might be potent anti-obesity agents. Experimental results on animals showed that the extract significantly reduced food intake and adipose, and effectively controlled weight evolution. Lipogenesis inhibition might be regarded as one of the reasons for the weight control and adipose reduction by AT. The extract was further isolated using a series of column chromatography that yielded 10 known compounds. 1,2,3,4,6-Penta-O-galloyl-β-D-glucose was found to be one of the major active constituents in the extract of AT.
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China. zwhua@ccmu.edu.cn
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhao
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Gao
authors.forename: Wen
authors.initials: W
authors.lastname: Gao
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Yuan
authors.forename: Chun-Chun
authors.initials: CC
authors.lastname: Gao
authors.forename: Li-Ge
authors.initials: LG
authors.lastname: Cao
authors.forename: Zi-Zheng
authors.initials: ZZ
authors.lastname: Hu
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Guo
authors.forename: Ying-Xia
authors.initials: YX
authors.lastname: Zhang
mesh_terms: D031002:Acer / Q000737:chemistry*; D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors*; D008297:Male; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019440:Anti-Obesity Agents; D064429:Fatty Acid Synthases