title: High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life.
abstract: We completed a cross-sectional study of individuals infected with human immunodeficiency virus in early childhood using cardiac magnetic resonance imaging and magnetic resonance angiography. Coronary artery abnormality (CAA) was defined by the presence of luminal narrowing and irregularity of the coronary vessel wall. More than 50% of participants (14/27) had evidence of CAA. Individuals had a high rate of CAA, suggesting possible early atherosclerosis.
authors.affiliation: National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-1662, USA. jacoubi@mail.nih.gov
authors.forename: Irene J
authors.initials: IJ
authors.lastname: Mikhail
authors.forename: Julia B
authors.initials: JB
authors.lastname: Purdy
authors.forename: David S
authors.initials: DS
authors.lastname: Dimock
authors.forename: Vijaya M
authors.initials: VM
authors.lastname: Thomas
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Muldoon
authors.forename: Sarah B
authors.initials: SB
authors.lastname: Clauss
authors.forename: Russell R
authors.initials: RR
authors.lastname: Cross
authors.forename: Roderic I
authors.initials: RI
authors.lastname: Pettigrew
authors.forename: Rohan
authors.initials: R
authors.lastname: Hazra
authors.forename: Colleen
authors.initials: C
authors.lastname: Hadigan
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Gharib
mesh_terms: D000293:Adolescent; D000328:Adult; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D055815:Young Adult