title: HiJAKing the methylosome in myeloproliferative disorders.
abstract: JAK2 gain-of-function mutations have been shown to cause myeloproliferative neoplasms. In this issue of Cancer Cell, Liu et al. (2011) demonstrate that these JAK2 mutants, but not wild-type JAK2, directly phosphorylate PRMT5 and inhibit its arginine methyltransferase activity, establishing a link between mutant JAK2 and histone arginine methylation.
authors.affiliation: Department of Biomedicine, University Hospital Basel, Basel, Switzerland. radek.skoda@unibas.ch
authors.forename: Radek C
authors.initials: RC
authors.lastname: Skoda
authors.forename: Jürg
authors.initials: J
authors.lastname: Schwaller