title: Arterial spin-labeling MR imaging in moyamoya disease compared with SPECT imaging.
abstract: OBJECTIVE
  Arterial spin-labeling (ASL) is a noninvasive magnetic resonance (MR) imaging method used to obtain brain perfusion information on various cerebrovascular diseases. We retrospectively compared the use of ASL-MRI and single-photon emission CT (SPECT) imaging to determine absolute cerebral blood flow (CBF) in moyamoya disease.
  
  
  METHODS
  CBF examinations using ASL-MRI on 3-T MRI and SPECT imagings with iodine-123-N-isopropyl-p-iodoamphetamine at resting (rest-IMP) and after acetazolamide challenge (ACZ-IMP) were performed on 12 patients with moyamoya disease (men, 5; women, 7; age range/average (year), 7-66/35.0). The CBF values determined by ASL-MRI (ASL-value), rest-IMP (rest-IMP-value), and ACZ-IMP (ACZ-IMP-value) of cerebral hemispheres (24 sides) were measured with normalized CBF maps created from data of those 3 perfusion imaging methods. Cerebrovascular reactivity (CVR) was calculated as follows: {(ACZ-IMP-value)-(rest-IMP-value)}/(rest-IMP-value)×100 (%). The ASL-value was compared with the rest-IMP-value, ACZ-IMP-value, and CVR.
  
  
  RESULTS
  The ASL-value, rest-IMP-value, ACZ-IMP-value, and CVR (average±standard deviation) were 26.6±14.8 (mL/100 g/min), 27.5±6.4 (mL/100 g/min), 37.1±13.2 (mL/100 g/min), and 35.9±44.3 (%), respectively. Significant relationships between the ASL-value versus (vs.) the rest-IMP-value (rs=0.500, p<0.05), the ASL-value vs. the ACZ-IMP-value (rs=0.863, p<0.01), and the ASL-value vs. the CVR (rs=0.699, p<0.01) were observed.
  
  
  CONCLUSIONS
  Although the ASL-value was lower than the rest-IMP-value, the significant relationship between the ASL-value and the rest-IMP-value may suggest that perfusion imaging by ASL-MRI could be used to recognize the condition of brain perfusion. In particular, the stronger correlation coefficient between the ASL-value and ACZ-IMP-value might suggest that perfusion imaging by ASL-MRI could show the potentially dangerous zone for ischemia.
authors.affiliation: Department of Radiology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan. tnogucci@radiol.med.kyushu-u.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Noguchi
authors.forename: Masatou
authors.initials: M
authors.lastname: Kawashima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Irie
authors.forename: Takateru
authors.initials: T
authors.lastname: Ootsuka
authors.forename: Masashi
authors.initials: M
authors.lastname: Nishihara
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsushima
authors.forename: Sho
authors.initials: S
authors.lastname: Kudo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation; D002648:Child; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000175:diagnosis* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D055815:Young Adult
chemical_list: D013113:Spin Labels