title: Nickel-catalyzed Negishi cross-coupling reactions of secondary alkylzinc halides and aryl iodides.
abstract: A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and β-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF(4) dramatically improves both isomeric retention and yield for challenging substrates.
authors.affiliation: Department of Chemistry, The City College of New York, New York, New York, USA.
authors.forename: Amruta
authors.initials: A
authors.lastname: Joshi-Pangu
authors.forename: Madhu
authors.initials: M
authors.lastname: Ganesh
authors.forename: Mark R
authors.initials: MR
authors.lastname: Biscoe