title: Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes.
abstract: The aim was to determine whether serum prorenin levels affect the development of diabetic retinopathy (DR) in type 2 diabetes. Baseline serum prorenin levels were measured in 196 patients (85 males, 111 females) with type 2 diabetes without DR using the antibody-activating direct prorenin assay. The fundi were checked regularly. The participants were divided into two groups based on the serum prorenin levels (high and low). We used Kaplan-Meyer analysis to detect differences in the development of DR between the two groups within the same gender. Kaplan-Meyer analysis showed that males with a high serum prorenin level tended to develop DR earlier and more frequently than males with a low prorenin level ( p = 0.004 by the log rank test). However, there was no difference in the development of DR between high and low groups in females (p = 0.58). Serum prorenin levels in males with type 2 diabetes could be a new prognostic indicator of the development of DR.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan. hyokota@mcg.edu
authors.forename: Harumasa
authors.initials: H
authors.lastname: Yokota
authors.forename: Taiji
authors.initials: T
authors.lastname: Nagaoka
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Tani
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Sato
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kato
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D003930:Diabetic Retinopathy / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System
chemical_list: D012083:Renin