title: The effect of biological and synthetic meshes on vaginal smooth muscle cell proliferation.
abstract: OBJECTIVE
  To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation.
  
  
  RESULTS
  Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular collagen matrix mesh exposed cells compared to the type I polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.03 vs. 0.21 ± 0.01, P = 0.03). Under estradiol supplementation cell proliferation in the porcine mesh exposed cells remained significantly higher compared to the polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.04 vs. 0.15 ± 0.03, P < 0.01).
  
  
  CONCLUSIONS
  The decreased rate of erosion found with the utilization of biological absorbable mesh in vaginal reconstructive surgery may partially be explained by the significantly increased VaSMC proliferation with porcine dermal acellular collagen mesh compared to polypropylene mesh.
authors.affiliation: Department of Obstetrics and Gynecology, University of Miami, Miller School of Medicine, Miami, Florida 33010, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Gualtieri
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Keith
authors.initials: K
authors.lastname: Candiotti
authors.forename: Sujata
authors.initials: S
authors.lastname: Yavagal
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Medina
authors.forename: Peter
authors.initials: P
authors.lastname: Takacs
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D003094:Collagen; D004867:Equipment Design; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000187:drug effects*; D011126:Polypropylenes; D013526:Surgical Mesh; D013552:Swine; D014621:Vagina / Q000166:cytology / Q000187:drug effects*
chemical_list: D011126:Polypropylenes; D004958:Estradiol; D003094:Collagen