title: Controlled curing of adhesive complex coacervates with reversible periodate carbohydrate complexes.
abstract: Periodate oxidation of carbohydrates with vicinal hydroxyl groups and aromatic ortho-dihydroxyphenyl groups has been employed extensively to initiate crosslinking or conjugation reactions in adhesive biomaterials. Periodate forms stable tridentate complexes with carbohydrates containing three appropriately configured hydroxyls, such as 1,2-O-isopropylidene-a-D-glucofuranose, that are not appreciably oxidized relative to carbohydrates with vicinal hydroxyls and ortho-dihydroxyphenyl groups. In the presence of 1,2-O-Isopropylidene-a-D-glucofuranose the rate of periodate oxidation of dihydroxy containing compounds is controlled by the rates of association and dissociation of the periodate-carbohydrate complex. By varying the ratio of 1,2-O-isopropylidene-a-D-glucofuranose to periodate the curing rate of adhesive complex coacervates was varied over a wide range.
authors.affiliation: Department of Bioengineering, University of Utah, 20 S. 2030 East, Room 506C, Salt Lake City, Utah 84112.
authors.forename: Hui
authors.initials: H
authors.lastname: Shao
authors.forename: G Mahika
authors.initials: GM
authors.lastname: Weerasekare
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Stewart
mesh_terms: D000268:Adhesiveness; D002241:Carbohydrates / Q000737:chemistry*; D055119:Elastic Modulus; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D010084:Oxidation-Reduction; D010504:Periodic Acid / Q000737:chemistry*; D010655:Phenylenediamines / Q000737:chemistry; D012212:Rheology; D033081:Shear Strength
chemical_list: D002241:Carbohydrates; D010655:Phenylenediamines; D010504:Periodic Acid; C009288:metaperiodate