title: Image-guided bolus electron conformal therapy - a case study.
abstract: We report on our initial experience with daily image guidance for the treatment of a patient with a basal cell carcinoma of the nasal dorsum using bolus electron conformal therapy. We describe our approach to daily alignment using treatment machine-integrated megavoltage (MV) planar imaging in conjunction with cone beam CT (CBCT) volumetric imaging to ensure the best possible setup reproducibility. Based on MV imaging, beam aperture misalignment with the intended treatment region was as large as 0.5 cm in the coronal plane. Four of the five fractions analyzed show induced shifts when compared to digitally reconstructed radiographs (DRR), in the range of 0.2-0.5 cm. Daily inspection of CBCT images show that the bolus device can have significant tilt in any given direction by as much as 13° with respect to beam axis. In addition, we show that CBCT images reveal air gaps between bolus and skin that vary from day to day, and can potentially degrade surface dose coverage. Retrospective dose calculation on CBCT image sets shows that when daily shifts based on MV imaging are not corrected, geometrical miss of the planning target volume (PTV) can cause an underdosing as large as 14% based on DVH analysis of the dose to the 90% of the PTV volume.
authors.affiliation: Department of Radiation Oncology, M.D. Anderson Cancer Center Orlando, Orlando, FL 32806, USA. omar.zeidan@orlandohealth.com
authors.forename: Omar A
authors.initials: OA
authors.lastname: Zeidan
authors.forename: Bhavin D
authors.initials: BD
authors.lastname: Chauhan
authors.forename: William W
authors.initials: WW
authors.lastname: Estabrook
authors.forename: Twyla R
authors.initials: TR
authors.lastname: Willoughby
authors.forename: Rafael R
authors.initials: RR
authors.lastname: Manon
authors.forename: Sanford L
authors.initials: SL
authors.lastname: Meeks
mesh_terms: D000465:Algorithms; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D004583:Electrons / Q000627:therapeutic use; D006801:Humans; D009669:Nose Neoplasms / Q000532:radiotherapy*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*