title: Immunogenicity and cross-reactivity of 2009-2010 inactivated seasonal influenza vaccine in US adults and elderly.
abstract: The campaign of 2009-2010 Northern Hemisphere seasonal vaccination was concurrent with the 2009 H1N1 pandemic. Using a hemagglutination inhibition (HAI) assay, we evaluated the immunogenicity and cross-reactivity of 2009-2010 inactivated trivalent influenza vaccine (TIV) in US adult and elderly populations. Vaccination of TIV resulted in a robust boost on the antibody response of all subjects to seasonal A/Brisbane/59/2007 (H1N1) and A/Uruguay/716/2007 (H3N2) with over 70% of recipients reaching a seroprotective titer of 40. B/Brisbane/60/2008 was the least immunogenic among the three seasonal vaccine strains with <30% of TIV recipients reaching a seroprotective titer of 40. TIV vaccination also induced a moderate boost on the pandemic specific antibody responses. Twenty-four percent of adults and 36% of elderly reached a seroprotective HAI titer of 40 or more against pandemic A/South Carolina/18/2009 (H1N1) after receiving TIV compared to 4% and 7% at the beginning of vaccination, respectively. In addition, 22% of adults and 34% of elderly showed an increase of 4-fold or more in A/South Carolina/18/2009 specific HAI titers after TIV vaccination. The pandemic specific cross-reactive antibodies strongly correlated with the post-vaccination HAI titers against the seasonal H3N2 vaccine strain in all subjects.
authors.affiliation: Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccine Research and Review, United States Food and Drug Administration, Bethesda, Maryland, United States of America. Hang.Xie@fda.hhs.gov
authors.forename: Hang
authors.initials: H
authors.lastname: Xie
authors.forename: Xianghong
authors.initials: X
authors.lastname: Jing
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.forename: Zhengshi
authors.initials: Z
authors.lastname: Lin
authors.forename: Ewan
authors.initials: E
authors.lastname: Plant
authors.forename: Olga
authors.initials: O
authors.lastname: Zoueva
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral; D000917:Antibody Formation; D003429:Cross Reactions / Q000276:immunology*; D006386:Hemagglutination Tests; D006801:Humans; D007109:Immunity; D007252:Influenza Vaccines / Q000276:immunology*; D058873:Pandemics; D014481:United States
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines