title: Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner.
abstract: BACKGROUND
  Fanconi anemia (FA) is a rare autosomal recessive syndrome characterized by developmental abnormalities, progressive bone marrow failure, and predisposition to cancer. The key FA protein FANCD2 crosstalks with members of DNA damage and repair pathways that also play a role at telomeres. Therefore, we investigated whether FANCD2 has a similar involvement at telomeres.
  
  
  RESULTS
  We reveal that FANCD2 may perform a novel function separate to the FANCD2/BRCA pathway. This function includes FANCD2 interaction with one of the telomere components, the PARP family member tankyrase-1. Moreover, FANCD2 inhibits tankyrase-1 activity in vitro. In turn, FANCD2 deficiency increases the polyADP-ribosylation of telomere binding factor TRF1.
  
  
  CONCLUSIONS
  FANCD2 binding and inhibiting tankyrase-1PARsylation at telomeres may provide an additional step within the FA pathway for the regulation of genomic integrity.
authors.affiliation: Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Edifici C, Bellaterra, Barcelona 08193, Spain.|Cancer and Stem Cell Research Program, Duke-NUS Graduate Medical School, College Rd. 6, 169857, Singapore.
authors.forename: Alex
authors.initials: A
authors.lastname: Lyakhovich
authors.affiliation: Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Edifici C, Bellaterra, Barcelona 08193, Spain.|Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Spain.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Ramirez
authors.affiliation: Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Edifici C, Bellaterra, Barcelona 08193, Spain.
authors.forename: Andres
authors.initials: A
authors.lastname: Castellanos
authors.affiliation: Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Edifici C, Bellaterra, Barcelona 08193, Spain.|Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Spain.|Fred Hutchinson Cancer Research Center, Seattle, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Castella
authors.affiliation: Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Simons
authors.affiliation: Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.|Department of Biomedical Informatics, The Ohio State University, 460 W. 12th Avenue, Columbus, OH, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Parvin
authors.affiliation: Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Edifici C, Bellaterra, Barcelona 08193, Spain.|Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Surralles