title: Experimental trauma models: an update.
abstract: Treatment of polytrauma patients remains a medical as well as socioeconomic challenge. Although diagnostics and therapy improved during the last decades, multiple injuries are still the major cause of fatalities in patients below 45 years of age. Organ dysfunction and organ failure are major complications in patients with major injuries and contribute to mortality during the clinical course. Profound understanding of the systemic pathophysiological response is crucial for innovative therapeutic approaches. Therefore, experimental studies in various animal models are necessary. This review is aimed at providing detailed information of common trauma models in small as well as in large animals.
authors.affiliation: Trauma Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. michaelfrink@web.de
authors.forename: Michael
authors.initials: M
authors.lastname: Frink
authors.forename: Hagen
authors.initials: H
authors.lastname: Andruszkow
authors.forename: Christian
authors.initials: C
authors.lastname: Zeckey
authors.forename: Christian
authors.initials: C
authors.lastname: Krettek
authors.forename: Frank
authors.initials: F
authors.lastname: Hildebrand
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D014947:Wounds and Injuries