title: Aerobic physical activity improves endothelial function in the middle-aged patients with erectile dysfunction.
abstract: OBJECTIVE
  Physical activity (PhA) has proven to be a protective factor for normal erectile function. The aim of this study was to evaluate the effects of a standard protocol of aerobic PhA on quality of erectile dysfunction (ED) in patients with arterial ED.
  
  
  METHODS
  Fifty patients (48-62 years) were selected and underwent to standard protocol of aerobic PhA: 150 min of moderate intensity aerobic activity per week (group A). Twenty patients, matched aged, with vascular ED who did not accept to undergo the standard PhA's protocol, represented the control group. All patients were evaluated, by IIEF-5 questionnaire administration, penile eco color doppler and flow-cytometric analysis for detection of serum concentrations of original immunophenotype endothelial progenitor cells (EPCs) = CD45neg/CD34pos/CD144pos and endothelial microparticles (EMPs) = CD45neg/CD34neg/CD144pos.
  
  
  RESULTS
  After 3 months, group A showed IIEF 5 score and peak systolic velocity significantly higher (p < 0.05) compared to controls, and significantly lower values (p < 0.05) of acceleration time, in addition serum concentrations of EPCs and EMPs were significantly lower (p < 0.05) in group A compared to controls.
  
  
  CONCLUSIONS
  PhA improves quality of arterial ED, without other pharmacological approach, probably by reduced endothelial apoptosis. This study characterises the study of endothelial dysfunction by new cell circulating markers.
authors.affiliation: Section of Endocrinology, Andrology and Internal Medicine and Master in Andrological, Human Reproduction and Biotechnology Sciences, Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy. sandrolavignera@email.it
authors.forename: Sandro
authors.initials: S
authors.lastname: La Vignera
authors.forename: Rosita
authors.initials: R
authors.lastname: Condorelli
authors.forename: Enzo
authors.initials: E
authors.lastname: Vicari
authors.forename: Rosario
authors.initials: R
authors.lastname: D'Agata
authors.forename: Aldo
authors.initials: A
authors.lastname: Calogero
mesh_terms: D018618:Echocardiography, Doppler, Color; D042783:Endothelial Cells / Q000502:physiology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D007172:Erectile Dysfunction / Q000503:physiopathology* / Q000628:therapy; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000502:physiology; D010413:Penis / Q000098:blood supply; D012039:Regional Blood Flow / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D011795:Surveys and Questionnaires