title: Assessment of myocardial fibrosis with cardiovascular magnetic resonance.
abstract: Diffuse interstitial or replacement myocardial fibrosis is a common feature of a broad variety of cardiomyopathies. Myocardial fibrosis leads to impaired cardiac diastolic and systolic function and is related to adverse cardiovascular events. Cardiovascular magnetic resonance (CMR) may uniquely characterize the extent of replacement fibrosis and may have prognostic value in various cardiomyopathies. Myocardial longitudinal relaxation time mapping is an emerging technique that could improve CMR's diagnostic accuracy, especially for interstitial diffuse myocardial fibrosis. As such, CMR could be integrated in the monitoring and therapeutic management of a large number of patients. This review summarizes the advantages and limitations of CMR for the assessment of myocardial fibrosis.
authors.affiliation: Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21287-0409, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Mewton
authors.forename: Chia Ying
authors.initials: CY
authors.lastname: Liu
authors.forename: Pierre
authors.initials: P
authors.lastname: Croisille
authors.forename: David
authors.initials: D
authors.lastname: Bluemke
authors.forename: João A C
authors.initials: JA
authors.lastname: Lima
mesh_terms: D009202:Cardiomyopathies / Q000175:diagnosis / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011856:Radiographic Image Enhancement; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D003287:Contrast Media