title: Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3).
abstract: Urokinase-type plasminogen activator (uPA) is a serine protease that is involved in cancer progression, especially invasion and metastasis including prostate cancer. uPA activation is mediated by transactivation of uPAR and epidermal growth factor receptor (EGF-R) in prostate cancer progression. Prostate cancer (PC-3) cells have highly invasive capacity and they express uPA and uPAR gene. PC-3 cells are treated with quercetin, which inhibits invasion and migration of PC-3 cells. Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions. Quercetin inhibits cell survival factor β-catenin, NF-κB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions. But quercetin increased p38 mitogen-activated protein kinase protein expression. Our results suggest that quercetin inhibit migration and invasion of prostate cancer cells. It shows the value for treatment of invasive and metastasis type of prostate cancer.
authors.affiliation: ALM Post-Graduate Institute of Basic Medical Sciences/Endocrinology, University of Madras, Chennai, Tamil Nadu, India.
authors.forename: Kalimuthu
authors.initials: K
authors.lastname: Senthilkumar
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Arunkumar
authors.forename: Perumal
authors.initials: P
authors.lastname: Elumalai
authors.forename: Govindaraj
authors.initials: G
authors.lastname: Sharmila
authors.forename: Dharmalingam Nandhagopal
authors.initials: DN
authors.lastname: Gunadharini
authors.forename: Sivanantham
authors.initials: S
authors.lastname: Banudevi
authors.forename: Gunasekar
authors.initials: G
authors.lastname: Krishnamoorthy
authors.forename: Chellakan Selvanesan
authors.initials: CS
authors.lastname: Benson
authors.forename: Jagadeesan
authors.initials: J
authors.lastname: Arunakaran
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D015536:Down-Regulation; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D011794:Quercetin / Q000494:pharmacology*; D055293:Receptors, Urokinase Plasminogen Activator / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics / Q000378:metabolism
chemical_list: D055293:Receptors, Urokinase Plasminogen Activator; D011794:Quercetin; D066246:ErbB Receptors; D014568:Urokinase-Type Plasminogen Activator