title: HuR and myogenesis: being in the right place at the right time.
abstract: The process of muscle cell differentiation into myotubes, termed myogenesis, depends on a complex coordination of myogenic factors, many of which are regulated post-transcriptionally. HuR, an mRNA-binding protein, is responsible for regulating the expression of several such myogenic factors by stabilizing their mRNAs. The critical role for HuR in myogenesis also involves the nucleocytoplasmic shuttling ability of this protein. Indeed, in order to perform its stabilizing functions, HuR must accumulate in the cytoplasm. This requires its dissociation from the import factor Transportin 2 (TRN2) which is actually caused by the cleavage of a portion of cytoplasmic HuR. In this review, we describe the roles of HuR during myogenesis, and the mechanisms regulating its cytoplasmic accumulation. This article is part of a Special Issue entitled: Regulation of Signaling and Cellular Fate through Modulation of Nuclear Protein Import.
authors.affiliation: McGill University, Biochemistry Department and Rosalind and Morris Goodman Cancer Center, McGill University Montreal, Canada.
authors.forename: Christopher
authors.initials: C
authors.lastname: von Roretz
authors.forename: Pascal
authors.initials: P
authors.lastname: Beauchamp
authors.forename: Sergio
authors.initials: S
authors.lastname: Di Marco
authors.forename: Imed-Eddine
authors.initials: IE
authors.lastname: Gallouzi
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000502:physiology*; D020169:Caspases / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; D055785:Gene Knockdown Techniques; D006801:Humans; D028884:Karyopherins / Q000502:physiology; D032342:Muscle Cells / Q000166:cytology / Q000502:physiology; D024510:Muscle Development / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D016601:RNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000954:Antigens, Surface; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; C098770:ELAVL1 protein, human; D028884:Karyopherins; D016601:RNA-Binding Proteins; D020169:Caspases