title: Evaluation of iloprost to prevent vasospasm in coronary artery bypass grafts.
abstract: This study assessed the efficacy of iloprost in relieving vasospasm in coronary artery bypass grafts. Radial artery (RA), left internal thoracic artery (LITA) and saphenous vein (SV) grafts were taken from 20 patients (13 men and seven women, mean age 63.8 years [range 48-74 years]) scheduled to undergo coronary artery bypass grafting. Ten 3 mm vascular rings were cut from each graft and kept under tension for at least 60 min. They were kept alive with 37 degrees C oxygenated Krebs solution. Smooth muscle contraction was achieved with phenylephrine before iloprost was administered every 2 min, starting at a concentration of 10(-9) mol/l and increasing in logarithmic increments to a concentration of 10(-5) mol/l. The vasodilation response to iloprost started in all samples at a concentration of 10(-9) mol/l and increased with each incremental increase in iloprost concentration up to 10(-5) mol/l. These data suggest that local administration of iloprost has a role in relieving graft vasospasm during harvesting and preparation for coronary artery bypass grafting.
authors.affiliation: Department of Cardiovascular Surgery, Trakya University Medical Faculty, Edirne, Turkey. turanege@hotmail.com
authors.forename: T
authors.initials: T
authors.lastname: Ege
authors.forename: O
authors.initials: O
authors.lastname: Gur
authors.forename: C H
authors.initials: CH
authors.lastname: Karadag
authors.forename: E
authors.initials: E
authors.lastname: Duran
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use*; D008297:Male; D008323:Mammary Arteries / Q000187:drug effects; D008875:Middle Aged; D017534:Radial Artery / Q000187:drug effects; D012501:Saphenous Vein / Q000187:drug effects; D013035:Spasm / Q000517:prevention & control*; D014652:Vascular Diseases / Q000517:prevention & control*; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost