title: Neuronal dynamics underlying high- and low-frequency EEG oscillations contribute independently to the human BOLD signal.
abstract: Work on animals indicates that BOLD is preferentially sensitive to local field potentials, and that it correlates most strongly with gamma band neuronal synchronization. Here we investigate how the BOLD signal in humans performing a cognitive task is related to neuronal synchronization across different frequency bands. We simultaneously recorded EEG and BOLD while subjects engaged in a visual attention task known to induce sustained changes in neuronal synchronization across a wide range of frequencies. Trial-by-trial BOLD fluctuations correlated positively with trial-by-trial fluctuations in high-EEG gamma power (60-80 Hz) and negatively with alpha and beta power. Gamma power on the one hand, and alpha and beta power on the other hand, independently contributed to explaining BOLD variance. These results indicate that the BOLD-gamma coupling observed in animals can be extrapolated to humans performing a task and that neuronal dynamics underlying high- and low-frequency synchronization contribute independently to the BOLD signal.
authors.affiliation: Donders Institute for Brain Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands. rene.scheeringa@donders.ru.nl
authors.forename: René
authors.initials: R
authors.lastname: Scheeringa
authors.forename: Pascal
authors.initials: P
authors.lastname: Fries
authors.forename: Karl-Magnus
authors.initials: KM
authors.lastname: Petersson
authors.forename: Robert
authors.initials: R
authors.lastname: Oostenveld
authors.forename: Iris
authors.initials: I
authors.lastname: Grothe
authors.forename: David G
authors.initials: DG
authors.lastname: Norris
authors.forename: Peter
authors.initials: P
authors.lastname: Hagoort
authors.forename: Marcel C M
authors.initials: MC
authors.lastname: Bastiaansen
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D055815:Young Adult