title: Effect of plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on contents of steroid hormones and NO level in rats.
abstract: Introduction of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17β-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%, respectively. ESR spectroscopy with diethyldithiocarbamateiron complex as a spin trap showed more than twofold increase in NO production in lungs, but not in blood, liver, and intestines, following the SkQ1 daily introduction at a dose of 25 nmol/kg.
authors.affiliation: Research Institute of Biology, Southern Federal University, Rostov-na-Donu 344090, Russia. vladimirchi@yandex.ru
authors.forename: V A
authors.initials: VA
authors.lastname: Chistyakov
authors.forename: V A
authors.initials: VA
authors.lastname: Serezhenkov
authors.forename: A A
authors.initials: AA
authors.lastname: Alexandrova
authors.forename: N P
authors.initials: NP
authors.lastname: Milyutina
authors.forename: V N
authors.initials: VN
authors.lastname: Prokof'ev
authors.forename: E V
authors.initials: EV
authors.lastname: Mashkina
authors.forename: L V
authors.initials: LV
authors.lastname: Gutnikova
authors.forename: S V
authors.initials: SV
authors.lastname: Dem'yanenko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004958:Estradiol / Q000096:biosynthesis* / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000097:blood; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D011374:Progesterone / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood
chemical_list: C532038:10-(6'-plastoquinonyl)decyltriphenylphosphonium; D000975:Antioxidants; D009569:Nitric Oxide; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D010971:Plastoquinone; D006854:Hydrocortisone