title: Amination with Pd-NHC complexes: rate and computational studies on the effects of the oxidative addition partner.
abstract: Pd-PEPPSI-IPent, a recently-developed N-heterocyclic carbene (NHC) complex, has been evaluated in amination reactions with secondary amines and it has shown superb reactivity under the most mildly basic reaction conditions. Rate and computational studies were conducted to provide insight into the mechanism of the transformation. The IPent catalyst coordinates to the amine much more strongly than the IPr variant, thus favouring deprotonation with comparatively weak bases. Indeed the reaction is first order in base and only slightly more than zeroth order in amine.
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, ON, M3J 1P3, Canada.
authors.forename: Ka Hou
authors.initials: KH
authors.lastname: Hoi
authors.forename: Selçuk
authors.initials: S
authors.lastname: Çalimsiz
authors.forename: Robert D J
authors.initials: RD
authors.lastname: Froese
authors.forename: Alan C
authors.initials: AC
authors.lastname: Hopkinson
authors.forename: Michael G
authors.initials: MG
authors.lastname: Organ