title: Percutaneous vertebroplasty in multiple myeloma: prospective long-term follow-up in 106 consecutive patients.
abstract: OBJECTIVE
  Percutaneous vertebroplasty (PV) is a minimally invasive procedure involving the injection of bone cement within a collapsed vertebral body. Although this procedure was demonstrated to be effective in osteoporosis and metastases, few studies have been reported in cases of multiple myeloma (MM). We prospectively evaluated the safety and efficacy of PV in the treatment of vertebral compression fractures (VCFs) resulting from MM.
  
  
  METHODS
  PV was performed in 106 consecutive MM patients who had back pain due to VCFs, the treatment of which had failed conservative therapies. Follow-up (28.2 ± 12.1 months) was evaluated at 7 and 15 days as well as at 1, 3, 6, 12, 18, and every 6 months after PV. Visual analog scale (VAS) pain score, opioid use, external brace support, and Oswestry Disability Index (ODI) score were recorded.
  
  
  RESULTS
  The median pretreatment VAS score of 9 (range 4-10) significantly (P < 0.001) decreased to 1 (range 0-9) after PV. Median pre-ODI values of 82% (range 36-89%) significantly improved to 7% (range 0-82%) (P < 0.001). Differences in pretreatment and posttreatment use of analgesic drug were statistically significant (P < 0.001). The majority of patients (70 of 81; 86%) did not use an external brace after PV (P < 0.001).
  
  
  CONCLUSIONS
  PV is a safe, effective, and long-lasting procedure for the treatment of vertebral compression pain resulting from MM.
authors.affiliation: Interventional Radiology Unit, Institute for Cancer Research and Treatment, 10060 Candiolo, Turin, Italy. giovanni.anselmetti@ircc.it
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Anselmetti
authors.forename: Antonio
authors.initials: A
authors.lastname: Manca
authors.forename: Filippo
authors.initials: F
authors.lastname: Montemurro
authors.forename: Joshua
authors.initials: J
authors.lastname: Hirsch
authors.forename: Gabriele
authors.initials: G
authors.lastname: Chiara
authors.forename: Giovanni
authors.initials: G
authors.lastname: Grignani
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Carnevale Schianca
authors.forename: Antonio
authors.initials: A
authors.lastname: Capaldi
authors.forename: Delia
authors.initials: D
authors.lastname: Rota Scalabrini
authors.forename: Elena
authors.initials: E
authors.lastname: Sardo
authors.forename: Felicino
authors.initials: F
authors.lastname: Debernardi
authors.forename: Gabriella
authors.initials: G
authors.lastname: Iussich
authors.forename: Daniele
authors.initials: D
authors.lastname: Regge
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements; D001915:Braces; D004185:Disability Evaluation; D005260:Female; D005471:Fluoroscopy; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy*; D010147:Pain Measurement; D011446:Prospective Studies; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy*; D013125:Spinal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy*; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D054854:Vertebroplasty / Q000379:methods*
chemical_list: D001843:Bone Cements