title: Endometrial LGR7 expression during menstrual cycle.
abstract: In a prospective observational study, 50 healthy patients aged 18-39 years, with regular ovulatory cycle and normal hormone levels, underwent endometrial biopsy in the proliferative and secretory phase of the menstrual cycle for semiquantitative reverse-transcription polymerase chain reaction analysis of mRNA for LGR7, the classic relaxin receptor. LGR7 is constitutively expressed in human endometrium, and an increased LGR7 immunostaining is demonstrated in the secretory phase, confirming the involvement of relaxin in the physiology of endometrium and suggesting its role in implantation.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, Second University of Naples, Naples, Italy.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Campitiello
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Franciscis
authors.forename: Daniela
authors.initials: D
authors.lastname: Mele
authors.forename: Gaia
authors.initials: G
authors.lastname: Izzo
authors.forename: Antonio
authors.initials: A
authors.lastname: Sinisi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Delrio
authors.forename: Nicola
authors.initials: N
authors.lastname: Colacurci
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D010064:Embryo Implantation; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007558:Italy; D008597:Menstrual Cycle / Q000235:genetics / Q000378:metabolism*; D011446:Prospective Studies; D012333:RNA, Messenger / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D018000:Receptors, Peptide / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; C417543:RXFP1 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide