title: Oral administration of recombinant human acid α-glucosidase reduces specific antibody formation against enzyme in mouse.
abstract: Animal and human studies of enzyme replacement therapy for Pompe disease have indicated that antibodies generated against the infused recombinant human acid α-glucosidase (rhGAA) can negatively impact therapeutic outcome. In this study, we show that oral administration of rhGAA into mice can reduce the titer of anti-rhGAA antibody following immunization with rhGAA. Oral administration of rhGAA is safe and antigen specific, it offers advantages over other immunosuppressive drugs.
authors.affiliation: Department of Gene Therapy, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohashi
authors.forename: S
authors.initials: S
authors.lastname: Iizuka
authors.forename: Y
authors.initials: Y
authors.lastname: Shimada
authors.forename: Y
authors.initials: Y
authors.lastname: Eto
authors.forename: H
authors.initials: H
authors.lastname: Ida
authors.forename: S
authors.initials: S
authors.lastname: Hachimura
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000906:Antibodies / Q000097:blood* / Q000276:immunology*; D000917:Antibody Formation; D004195:Disease Models, Animal; D056947:Enzyme Replacement Therapy; D006009:Glycogen Storage Disease Type II / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000008:administration & dosage; D000520:alpha-Glucosidases / Q000276:immunology*
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D011994:Recombinant Proteins; D007073:Immunoglobulin E; C509951:GAA protein, human; D000520:alpha-Glucosidases