title: Acute starvation in pregnancy: a cause of severe metabolic acidosis.
abstract: We report a case of starvation-induced metabolic ketoacidosis in a previously healthy 29-year-old, nulliparous woman at 32 weeks of gestation. She was admitted to hospital with mild preeclampsia associated with persistent nausea and vomiting that progressed to severe preeclampsia requiring urgent control of hypertension before caesarean delivery. Prolonged and severe vomiting limited oral caloric intake and led to starvation ketoacidosis, characterised by ketonuria and a raised anion gap metabolic acidosis that required intensive care support. Despite significant metabolic derangement the patient appeared clinically well. Intravascular volume was replenished. Fluid restriction used as part of our preeclampsia treatment regimen delayed the therapeutic administration of sufficient dextrose, which rapidly corrected her metabolic derangement when commenced after delivery. Electrolyte supplementation was given to prevent re-feeding syndrome. Both mother and baby were discharged without sequelae.
authors.affiliation: Department of Intensive Care Medicine and Anaesthesia, Hammersmith Hospital, London, UK. amit.patel@imperial.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: D
authors.initials: D
authors.lastname: Felstead
authors.forename: M
authors.initials: M
authors.lastname: Doraiswami
authors.forename: G M
authors.initials: GM
authors.lastname: Stocks
authors.forename: U
authors.initials: U
authors.lastname: Waheed
mesh_terms: D000138:Acidosis / Q000209:etiology* / Q000628:therapy; D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007662:Ketosis / Q000209:etiology* / Q000628:therapy; D011225:Pre-Eclampsia; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D013217:Starvation / Q000150:complications*; D014839:Vomiting / Q000150:complications / Q000188:drug therapy; D014883:Water-Electrolyte Imbalance / Q000150:complications
chemical_list: D000932:Antiemetics