title: An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays.
abstract: In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA × DBA/2 and CBA × BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.
authors.affiliation: INSERM U782, UMR 0782, Hôpital Béclère, Clamart, and University Paris XI, Orsay, France. gerard chaouat@wanadoo.fr
authors.forename: Gérard
authors.initials: G
authors.lastname: Chaouat
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rodde
authors.forename: Marie
authors.initials: M
authors.lastname: Petitbarat
authors.forename: Roberta
authors.initials: R
authors.lastname: Bulla
authors.forename: Mona
authors.initials: M
authors.lastname: Rahmati
authors.forename: Sylvie
authors.initials: S
authors.lastname: Dubanchet
authors.forename: Sandrine
authors.initials: S
authors.lastname: Zourbas
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bataillon
authors.forename: Nathalie
authors.initials: N
authors.lastname: Coqué
authors.forename: Benoit
authors.initials: B
authors.lastname: Hennuy
authors.forename: Jacques
authors.initials: J
authors.lastname: Martal
authors.forename: Carine
authors.initials: C
authors.lastname: Munaut
authors.forename: Julie
authors.initials: J
authors.lastname: Aubert
authors.forename: Valérie
authors.initials: V
authors.lastname: Sérazin
authors.forename: Thiel
authors.initials: T
authors.lastname: Steffen
authors.forename: Jens Christian
authors.initials: JC
authors.lastname: Jensenius
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Olivier
authors.initials: O
authors.lastname: Sandra
authors.forename: Francesco
authors.initials: F
authors.lastname: Tedesco
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lédée
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D011225:Pre-Eclampsia / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy