title: Fucoidans from brown seaweeds Sargassum hornery, Eclonia cava, Costaria costata: structural characteristics and anticancer activity.
abstract: Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.
authors.affiliation: Pacific Institute of Bioorganic Chemistry of Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia. svetlana_ermakova@hotmail.com
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ermakova
authors.forename: Roza
authors.initials: R
authors.lastname: Sokolova
authors.forename: Sang-Min
authors.initials: SM
authors.lastname: Kim
authors.forename: Byung-Hun
authors.initials: BH
authors.lastname: Um
authors.forename: Vladimir
authors.initials: V
authors.lastname: Isakov
authors.forename: Tatyana
authors.initials: T
authors.lastname: Zvyagintseva
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012624:Seaweed / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011134:Polysaccharides; C007789:fucoidan