title: The role of Hepatitis C Virus in the dynamic protein interaction networks of hepatocellular cirrhosis and carcinoma.
abstract: As an important risk factor for Hepatocellular Carcinoma (HCC), Hepatitis C Virus (HCV) infection can induce cirrhosis and HCC. But, the molecular mechanisms of HCV-induced transformation remain largely unknown. In this study, first, we identified the dysfunctional protein interaction networks in cirrhosis and HCC based on the gene expression profiles of 19 normal, 58 cirrhotic and 47 HCC liver tissues. Then, the relationship between dysfunctional networks and HCV infection was analysed. Our results may help understand the mechanisms of HCV-induced malignant transformation and provide clues to cirrhosis and HCC therapy or prevention.
authors.affiliation: Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. huangtao@sibs.ac.cn
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.forename: Guohui
authors.initials: G
authors.lastname: Ding
authors.forename: Yejun
authors.initials: Y
authors.lastname: Tan
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Tu
authors.forename: Yixue
authors.initials: Y
authors.lastname: Li
authors.forename: Hongyue
authors.initials: H
authors.lastname: Dai
authors.forename: Lu
authors.initials: L
authors.lastname: Xie
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000821:virology*; D002472:Cell Transformation, Viral / Q000502:physiology; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling; D016174:Hepacivirus / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism / Q000821:virology*; D008113:Liver Neoplasms / Q000378:metabolism / Q000821:virology*; D025941:Protein Interaction Mapping; D015398:Signal Transduction