title: A cascade Heck-Aldol-Heck reaction by a combination of transition-metal catalysis and aminocatalysis.
abstract: An unprecedented cascade Heck-Aldol-Heck reaction was developed to form two C-C single bonds and one C=C double bond in one process by a combination of palladium(0) catalysis and aminocatalysis. Various aryl iodides could perform the cascade reaction with readily available propenol and formaldehyde to afford novel (E)-trisubstituted alkenes in 66-81% yields.
authors.affiliation: Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Chang-Shan
authors.initials: CS
authors.lastname: Guo
authors.forename: Yu-Han
authors.initials: YH
authors.lastname: Du
authors.forename: Zhi-Zhen
authors.initials: ZZ
authors.lastname: Huang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007454:Iodides / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000588:Amines; D007454:Iodides; D010165:Palladium