title: Serum complement C3 has a stronger association with insulin resistance than high-sensitivity C-reactive protein in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare the association of complement C3 (C3) versus high-sensitivity C-reactive protein (hs-CRP) with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Cross-sectional analysis.
  
  
  METHODS
  Clinical research center in China.
  
  
  METHODS
  One hundred thirty-three women with PCOS and 116 healthy, age-matched controls were recruited.
  
  
  METHODS
  None.
  
  
  METHODS
  One hundred one women with PCOS and 20 controls underwent hyperinsulinemic-euglycemic clamp to assess their insulin sensitivity, which was expressed as an M value.
  
  
  RESULTS
  Compared with controls, women with PCOS had a lower M value and higher C3 (1.37 ± 0. 34 vs. 1.10 ± 0.22 g/L) and hs-CRP levels (1.46 ± 2.29 vs. 0.49 ± 0.88 mg/L). In women with PCOS, C3 and hs-CRP negatively correlated with M value (r = -0.61 and r = -0.47, respectively). By regression analysis, C3 was found to have a greater impact on the M value (standardized coefficient β = -0.24) than did hs-CRP (standardized coefficient β = -0.13). After adjusting for body mass index (BMI), women with PCOS in the upper quartile were 4.30 times more likely to exhibit IR compared with those in the lower quartiles, whereas hs-CRP was not a statistically significant predictor of IR in women with PCOS.
  
  
  CONCLUSIONS
  Compared with hs-CRP, serum C3 might be a stronger inflammatory marker of IR in women with PCOS.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Yang
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Song
authors.forename: Bo
authors.initials: B
authors.lastname: Tian
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Cheng
authors.forename: Hua
authors.initials: H
authors.lastname: Qing
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
mesh_terms: D000328:Adult; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D016022:Case-Control Studies; D003176:Complement C3 / Q000032:analysis* / Q000378:metabolism / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism; D013379:Substrate Specificity; D055815:Young Adult
chemical_list: D003176:Complement C3; D002097:C-Reactive Protein