title: Atrial fibrillation is a major risk factor for stroke, especially in women: the Jichi Medical School cohort study.
abstract: BACKGROUND
  Only a few population-based cohort studies have investigated the impact of atrial fibrillation (AF) on stroke in Japan.
  
  
  METHODS
  A total of 10 929 participants (4147 men and 6782 women) were included in this population-based prospective cohort study. Baseline data, including electrocardiograms (ECGs) to ascertain AF status, were obtained from April 1992 through July 1995 in 12 areas in Japan. Cox proportional hazards models were used to analyze the association of AF with stroke.
  
  
  RESULTS
  A total of 54 participants had AF (0.49%). The mean follow-up period was 10.7 years, during which 405 strokes were identified; 12 of these occurred in participants with AF. The crude incidence of stroke in participants with and without AF was 14.9 and 4.5 per 1000 person-years in men, respectively, and 39.3 and 2.7 per 1000 person-years in women. After adjusting for geographical area, sex, age, smoking status, drinking status, obesity, hypertension, dyslipidemia, and diabetes mellitus, the hazard ratios (95% confidence interval) of AF in all participants and in male and female participants were 4.11 (2.28-7.41), 2.12 (0.77-5.84), and 10.6 (5.01-22.4), respectively. The population attributable fraction (PAF) of stroke caused by AF was 2.2%; the PAFs were 1.0% and 3.6% in men and women, respectively.
  
  
  CONCLUSIONS
  The present Japanese population-based prospective cohort study showed that AF is a major risk factor for stroke, especially in women.
authors.affiliation: Department of Internal Medicine, Kamiichi General Hospital, Toyama, Japan. iwahana@jichi.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iwahana
authors.forename: Shizukiyo
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Joji
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kabutoya
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kayaba
authors.forename: Tadao
authors.initials: T
authors.lastname: Gotoh
authors.forename: Eiji
authors.initials: E
authors.lastname: Kajii
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology / Q000209:etiology*