title: Dysplasia and cancer in inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease associated with an increased risk of colorectal cancer (CRC). Although CRC occurs in a minority of IBD patients (1%), it carries a high mortality and accounts for 20% of IBD-related mortality. Established risk factors for the development of CRC in IBD include disease duration of 8 years or more, family history of CRC, extensive colitis and primary sclerosing cholangitis. Meticulous colonoscopy and anti-inflammatory medications can reduce the risk of developing CRC. The future of IBD surveillance involves the use of novel endoscopic techniques (chromoendoscopy, narrow-band imaging, confocal laser endomicroscopy and autofluorescence) to enhance colonoscopic accuracy, in concert with chemopreventative medications to help reduce the risk of CRC in IBD.
authors.affiliation: Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Basseri
authors.forename: Benjamin
authors.initials: B
authors.lastname: Basseri
authors.forename: Konstantinos A
authors.initials: KA
authors.lastname: Papadakis
mesh_terms: D003092:Colitis / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D012307:Risk Factors; D013997:Time Factors