title: Discovery of new inhibitor for PDE3 by virtual screening.
abstract: In this work, we tried to find a new scaffold for a PDE3 using virtual screening for the obesity treatment. We first analyzed structural features for the known PDE3 inhibitors based on the PDE3B-ligand complex structure, and then carried out a docking study based on PDE3B 3D structure. We obtained a compound as potent PDE3 inhibitor stimulating lipolysis in murine adipocytes and human adipocytes.
authors.affiliation: Bio-Organic Science Division, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon, South Korea.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Kim
authors.forename: Hyuk
authors.initials: H
authors.lastname: Lee
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Yoo
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Nam Sook
authors.initials: NS
authors.lastname: Kang
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D055808:Drug Discovery; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D058987:Phosphodiesterase 3 Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D058987:Phosphodiesterase 3 Inhibitors