title: No association between serum paraoxonase, arylesterase activities, and hydatidiform mole.
abstract: BACKGROUND
  In this study, we aimed to evaluate the association between hydatidiform mole (HM) and paraoxonase 1 (PON1) activity and phenotyping in comparison with healthy subjects (both pregnant and nonpregnant women).
  
  
  METHODS
  Eighty women were enrolled in this study. Of these, 26 had HM (group 1). Twenty-seven healthy women in the first trimester of pregnancy with a single viable fetus were included in the study as control subjects (group 2). The remaining 27 subjects were healthy nonpregnant women who also participated as control subjects (group 3). Paraoxonase and arylesterase activities were measured using commercially available kits (Relassay, Gaziantep, Turkey). Paraoxonase activity measurements were performed both in the absence (basal activity) and presence of NaCl (salt-stimulated activity). The phenotype distribution of PON1 activity was determined by the double-substrate method.
  
  
  RESULTS
  Basal and salt-stimulated paraoxonase and arylesterase activities were not significantly different between the HM, healthy pregnant control, and healthy nonpregnant control groups. Hence, PON1 phenotype distribution of the subjects was not significantly different between these 3 groups.
  
  
  CONCLUSIONS
  We determined no association between HM (complete or partial) and PON1 activity and phenotyping in comparison with pregnant and nonpregnant healthy subjects. Further studies including metastatic or invasive HM are needed.
authors.affiliation: Department of Obstetrics and Gynecology, Gaziantep University, Gaziantep, Turkey. ebruozturkarslan@yahoo.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Ozturk
authors.forename: Ozcan
authors.initials: O
authors.lastname: Balat
authors.forename: Ebru
authors.initials: E
authors.lastname: Dikensoy
authors.forename: Mete Gurol
authors.initials: MG
authors.lastname: Ugur
authors.forename: Caglayan
authors.initials: C
authors.lastname: Ozcan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Aydin
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.forename: Seval
authors.initials: S
authors.lastname: Kul
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000201:enzymology* / Q000473:pathology; D010641:Phenotype; D011247:Pregnancy; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase