title: Mutation Detection inTGF-β Receptors.
abstract: The transforming growth factor β (TGF-β) receptors are an important class of tumor suppressor gene. TGF-β markedly inhibits the growth of many epithelial cell types; whereas in contrast, cancers of many different tissue types are commonly TGF-β resistant (10). Many cancer cell lines are resistant to the growth suppressive effects of TGF-β and display evidence of disruption of TGF-β signal transduction (10,4,10). To date, this resistance appears to often result from mutations in the TGF-β receptors or the smad family of TGF-β signaling proteins (5,11,12,14,16).
authors.affiliation: Ireland Cancer Center, University Hospitals of Cleveland, Cleveland, OH.
authors.forename: W M
authors.initials: WM
authors.lastname: Grady
authors.forename: L L
authors.initials: LL
authors.lastname: Myeroff
authors.forename: H
authors.initials: H
authors.lastname: He
authors.forename: S
authors.initials: S
authors.lastname: Markowitz