title: Leukocytes and the natural history of deep vein thrombosis: current concepts and future directions.
abstract: Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution.
authors.affiliation: Kings College London, British Heart Foundation Centre of Research Excellence and National Institute for Health Research Biomedical Research Centre at Kings Health Partners, Academic Department of Surgery, St Thomas' Hospital, London, United Kingdom.
authors.forename: Prakash
authors.initials: P
authors.lastname: Saha
authors.forename: Julia
authors.initials: J
authors.lastname: Humphries
authors.forename: Bijan
authors.initials: B
authors.lastname: Modarai
authors.forename: Katherine
authors.initials: K
authors.lastname: Mattock
authors.forename: Matthew
authors.initials: M
authors.lastname: Waltham
authors.forename: Colin E
authors.initials: CE
authors.lastname: Evans
authors.forename: Anwar
authors.initials: A
authors.lastname: Ahmad
authors.forename: Ashish S
authors.initials: AS
authors.lastname: Patel
authors.forename: Sobath
authors.initials: S
authors.lastname: Premaratne
authors.forename: Oliver T A
authors.initials: OT
authors.lastname: Lyons
authors.forename: Alberto
authors.initials: A
authors.lastname: Smith
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000276:immunology*; D042783:Endothelial Cells / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology; D015398:Signal Transduction; D020246:Venous Thrombosis / Q000097:blood / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators