title: PCOS--what matters in early pregnancy?--data from a cross-sectional, multicenter study.
abstract: OBJECTIVE
  To describe patient characteristics according to different diagnostic criteria in early pregnancy, in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Descriptive, cross-sectional study of 257 women with PCOS in the first trimester of pregnancy.
  
  
  METHODS
  Data from a multicenter trial at the time of inclusion.
  
  
  METHODS
  257 PCOS women with singleton pregnancies.
  
  
  METHODS
  Investigator-administrated questionnaires were filled out. Clinical examination was performed by the investigators. Fasting blood samples were collected.
  
  
  METHODS
  Biometric data, androgens, glucose and insulin levels.
  
  
  RESULTS
  Women who met the National Institutes of Health (NIH) criteria for PCOS had higher body mass index (BMI), testosterone, dehydroepiandrostenedione, free testosterone index (FTI) and insulin levels compared with those who only met the Rotterdam consensus criteria. Adjusted for age and BMI, only testosterone and FTI were higher in those who met the NIH criteria. BMI was a strong, independent predictor of both systolic and diastolic blood pressure in early PCOS pregnancy, while both FTI and fasting insulin were independent predictors of systolic blood pressure. Twenty-two (9%) of the participants had gestational diabetes mellitus in the first trimester of pregnancy.
  
  
  CONCLUSIONS
  In the first trimester, PCOS women diagnosed according to NIH criteria were more metabolically and endocrinologically abnormal compared with those who only met the Rotterdam consensus criteria. BMI and FTI were independent predictive factors for blood pressure. There was a high prevalence of gestational diabetes mellitus in early PCOS pregnancies.
authors.affiliation: Dept. of Obstetrics and Gynecology, St. Olav's University Hospital Trondheim, Olav Kyrres gt. 17, Trondheim, Norway. Eszter.vanky@ntnu.no
authors.forename: Eszter
authors.initials: E
authors.lastname: Vanky
authors.forename: Solhild
authors.initials: S
authors.lastname: Stridsklev
authors.forename: Kristin
authors.initials: K
authors.lastname: Skogøy
authors.forename: Odrun
authors.initials: O
authors.lastname: Kleggetveit
authors.forename: Sissel
authors.initials: S
authors.lastname: Hjelle
authors.forename: Philip V
authors.initials: PV
authors.lastname: Brandis
authors.forename: Torunn
authors.initials: T
authors.lastname: Eikeland
authors.forename: Karin
authors.initials: K
authors.lastname: Flo
authors.forename: Kristin Flaten
authors.initials: KF
authors.lastname: Berg
authors.forename: Gabor
authors.initials: G
authors.lastname: Bunford
authors.forename: Agnethe
authors.initials: A
authors.lastname: Lund
authors.forename: Cecilie
authors.initials: C
authors.lastname: Bjerke
authors.forename: Ingunn
authors.initials: I
authors.lastname: Almås
authors.forename: Ann Hilde
authors.initials: AH
authors.lastname: Berg
authors.forename: Anna
authors.initials: A
authors.lastname: Danielsson
authors.forename: Gulim
authors.initials: G
authors.lastname: Lahmami
authors.forename: Sven M
authors.initials: SM
authors.lastname: Carlsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000735:Androstenedione / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology*; D011261:Pregnancy Trimester, First; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D013739:Testosterone; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; D002784:Cholesterol