title: Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox.
abstract: Autoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication.
authors.affiliation: Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, İzmir.
authors.forename: Maşallah
authors.initials: M
authors.lastname: Baran
authors.forename: Funda
authors.initials: F
authors.lastname: Özgenç
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Berk
authors.forename: Demir
authors.initials: D
authors.lastname: Gökçe
authors.forename: Kaan
authors.initials: K
authors.lastname: Kavakli
authors.forename: Funda
authors.initials: F
authors.lastname: Yilmaz
authors.forename: Sait
authors.initials: S
authors.lastname: Şen
authors.forename: Raşit Vural
authors.initials: RV
authors.lastname: Yağci
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy / Q000473:pathology* / Q000821:virology*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D002644:Chickenpox / Q000150:complications* / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D015726:Giant Cells / Q000276:immunology / Q000473:pathology; D006505:Hepatitis / Q000188:drug therapy / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007223:Infant; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab