title: New conjugates of β-cyclodextrin with manganese(III) salophen and porphyrin complexes as antioxidant systems.
abstract: Oxidative stress is the hallmark of several pathologies like arthritis, hypertension and many neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In this scenario, antioxidant compounds can play a pivotal role in treating these severe pathologies. The synthesis of molecules able to mimic physiologically-relevant proteins is nowadays of particular interest. Several transition metal complexes, especially manganese(III) complexes with porphyrin and salen-type ligands, have been reported to be superoxide scavengers. Here we report the synthesis and spectroscopic characterization of manganese(III) complexes of 5[4-(6-O-β-cyclodextrin)-phenyl],10,15,20-tri(4-hydroxyphenyl)-porphyrin and of 6(A)-deoxy-6(A)[(S-cysteamidobenzoyl(3,4-diamino)-N,N'-bis(salicylidene))]-β-cyclodextrin. The superoxide dismutase activity of the metal complexes was investigated by indirect methods. The catalase and peroxidase activities were tested using ABTS assays.
authors.affiliation: Dipartimento di Scienze Chimiche, University of Catania, V. le A. Doria 6, 95125, Catania, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Oliveri
authors.forename: Antonino
authors.initials: A
authors.lastname: Puglisi
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D008345:Manganese / Q000737:chemistry*; D010544:Peroxidases / Q000378:metabolism; D011166:Porphyrins / Q000737:chemistry*; D012459:Salicylates / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D056831:Coordination Complexes; D011166:Porphyrins; D012459:Salicylates; D047392:beta-Cyclodextrins; C090416:salophen; D008345:Manganese; D010544:Peroxidases; D002374:Catalase; D013482:Superoxide Dismutase; C031215:betadex