title: Primary malignant melanoma of the penis: a case report.
abstract: We present the case of a patient with malignant melanoma of the glans penis and urethral meatus, which was found in a 60-year-old man with non-healing ulcerative penile lesion and bilateral clinically palpable inguinal lymphadenopathies at diagnosis. A diagnostic biopsy showed the characteristics of a malignant melanoma. Incisional biopsies from the cutaneous lesions on his glans penis and urethra were performed. Histopathological examination of both specimens showed generally ulceronecrotic surface and numerous atypical melanocytic cells. The diagnosis of giant cell melanoma was made. Two months later, bilateral inguinal lymph nodes dissection was performed. Histopathological examination of both specimens demonstrated malignant melanoma metastasis. Three months after the diagnosis, the patient underwent partial penectomy. High-dose interferon-alpha-2b treatment was started. Early diagnosis is of paramount importance, as the prognosis becomes very poor with an advanced tumor stage.
authors.affiliation: Department of Medical Oncology, Pamukkale University, 20200 Kinikli, Denizli, Turkey. ggd2882@gmail.com
authors.forename: Gamze Gokoz
authors.initials: GG
authors.lastname: Dogu
authors.forename: Arzu
authors.initials: A
authors.lastname: Yaren
authors.forename: Levent
authors.initials: L
authors.lastname: Tuncay
authors.forename: Nilay
authors.initials: N
authors.lastname: Senturk
authors.forename: Ali Ersin
authors.initials: AE
authors.lastname: Zumrutbas
authors.forename: Burcu Yapar
authors.initials: BY
authors.lastname: Taskoylu
authors.forename: Ferda
authors.initials: F
authors.lastname: Bir
mesh_terms: D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D010412:Penile Neoplasms / Q000473:pathology* / Q000601:surgery; D011379:Prognosis