title: Dual association of a TRKA polymorphism with schizophrenia.
abstract: OBJECTIVE
  An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.
  
  
  METHODS
  We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.
  
  
  RESULTS
  Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.
  
  
  CONCLUSIONS
  An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors.
authors.affiliation: Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience and Nijmegen Centre for Molecular Life Sciences, Faculty of Science, Radboud University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Van Schijndel
authors.forename: Martine
authors.initials: M
authors.lastname: Van Zweeden
authors.forename: Karen M J
authors.initials: KM
authors.lastname: Van Loo
authors.forename: Srdjan
authors.initials: S
authors.lastname: Djurovic
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
authors.forename: Thomas
authors.initials: T
authors.lastname: Hansen
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.forename: Mette
authors.initials: M
authors.lastname: Nyegaard
authors.forename: Karina Meden
authors.initials: KM
authors.lastname: Sørensen
authors.forename: Merete
authors.initials: M
authors.lastname: Nordentoft
authors.forename: Preben B
authors.initials: PB
authors.lastname: Mortensen
authors.forename: Ole
authors.initials: O
authors.lastname: Mors
authors.forename: Anders D
authors.initials: AD
authors.lastname: Børglum
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
authors.forename: Karl-Fredrik
authors.initials: KF
authors.lastname: Norrback
authors.forename: Rolf
authors.initials: R
authors.lastname: Adolfsson
authors.forename: Marc
authors.initials: M
authors.lastname: De Hert
authors.forename: Stephan
authors.initials: S
authors.lastname: Claes
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Pekka
authors.initials: P
authors.lastname: Kallunki
authors.forename: Jan T
authors.initials: JT
authors.lastname: Pedersen
authors.forename: Gerard J M
authors.initials: GJ
authors.lastname: Martens
mesh_terms: D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D005060:Europe; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D020917:Receptor, trkA / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D014481:United States
chemical_list: D017931:DNA Primers; D020917:Receptor, trkA