title: Infusional mitoxantrone plus bolus melphalan as a stem cell transplant conditioning regimen for multiple myeloma.
abstract: This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees had received ≥ 2 prior treatments. The median overall survival was 5 years and 8 months, with 37% of the subjects alive >7 years posttransplantation. Myelosuppression and mucositis were the most frequent adverse events. This regimen is well tolerated and the survival compares well to other transplant trials.
authors.affiliation: Division of Oncology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. anne.beaven@duke.edu
authors.forename: Anne W
authors.initials: AW
authors.lastname: Beaven
authors.forename: Dominic T
authors.initials: DT
authors.lastname: Moore
authors.forename: Andrew
authors.initials: A
authors.lastname: Sharf
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Serody
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Shea
authors.forename: Don A
authors.initials: DA
authors.lastname: Gabriel
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008558:Melphalan / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage* / Q000009:adverse effects; D009101:Multiple Myeloma / Q000401:mortality / Q000601:surgery*; D019653:Myeloablative Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D019172:Transplantation Conditioning / Q000379:methods*; D014182:Transplantation, Autologous
chemical_list: D019653:Myeloablative Agonists; D008942:Mitoxantrone; D008558:Melphalan