title: Highly efficient organocatalytic kinetic resolution of activated nitroallylic acetates with aldehydes via conjugate addition-elimination.
abstract: A novel, efficient, and unprecedented organocatalytic kinetic resolution has been developed. For the first time, a variety of nitroallylic acetates 1a-i have been resolved with aldehydes in the presence of 2 (2.5 mol %) via conjugate addition-elimination. The densely functionalized products 3a-o were obtained with excellent enantioselectivities (up to >99% ee), and unreacted substrates 1a-i were recovered with good to excellent optical purity (up to 98% ee).
authors.affiliation: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 116, ROC.
authors.forename: Raju Jannapu
authors.initials: RJ
authors.lastname: Reddy
authors.forename: Kwunmin
authors.initials: K
authors.lastname: Chen