title: MicroRNAs: the fine-tuners of Toll-like receptor signalling.
abstract: Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation and to allow for tissue repair and the return to homeostasis after infection and tissue injury. MicroRNAs (miRNAs) have emerged as important controllers of TLR signalling. Several miRNAs are induced by TLR activation in innate immune cells and these and other miRNAs target the 3' untranslated regions of mRNAs encoding components of the TLR signalling system. miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases.
authors.affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. laoneill@tcd.ie
authors.forename: Luke A
authors.initials: LA
authors.lastname: O'Neill
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Sheedy
authors.forename: Claire E
authors.initials: CE
authors.lastname: McCoy
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D056704:Adaptive Immunity / Q000235:genetics; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D005544:Forecasting; D005786:Gene Expression Regulation / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D018448:Models, Immunological; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology*; D051193:Toll-Like Receptors / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D020413:3' Untranslated Regions; D016207:Cytokines; D035683:MicroRNAs; D012333:RNA, Messenger; D051193:Toll-Like Receptors; D014157:Transcription Factors