title: Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation.
abstract: Pigment epithelium-derived factor (PEDF) and pentosidine have received growing attention as sensitive biomarkers of the progression of atherosclerosis. The present study was performed to evaluate the utility of these biomarkers for assessing the effects of angiotensin II type 1 receptor blockers (ARBs). Sixty-three patients with coronary artery disease (CAD) following successful stent implantation were divided into an ARB group (n = 50), who initially received valsartan or olmesartan immediately following stent implantation, and a non-ARB group (n = 13) according to their blood pressure (BP) at baseline. Measurement of BP and blood sampling was performed prior to (at baseline) and 6-8 months following stent implantation (at follow-up). There were no significant differences in the baseline characteristics between the groups. Although there were no differences in the percentage of diameter re-stenosis between the groups, the BP level in the ARB group at follow-up showed a significant reduction and reached the target BP. The levels of plasma PEDF were significantly increased at follow-up in the ARB group, but not in the non-ARB group, while there were no differences in the levels of pentosidine between the groups. Changes in BP (ΔBP = BP at follow-up minus BP at baseline) were not associated with ΔPEDF. In conclusion, PEDF may be a useful biomarker for assessing the effects of ARBs independent of a reduction in BP.
authors.affiliation: Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugihara
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Miura
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Takamiya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kiya
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Arimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iwata
authors.forename: Akira
authors.initials: A
authors.lastname: Kawamura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Sho-Ichi
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D019917:Blood Vessel Prosthesis Implantation; D017023:Coronary Angiography; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives / Q000097:blood; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D015843:Serpins / Q000097:blood*; D015607:Stents; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001120:Arginine; D005136:Eye Proteins; D008239:Lysine; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor; C062187:pentosidine