title: Transcriptional regulation of the human telomerase reverse transcriptase: new insights.
abstract: hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments explains the link between hTERT expression and cell stimulation and offers new insights for therapeutic developments.
authors.affiliation: Université Claude Bernard - UMR, Oullins, France.
authors.forename: Amel
authors.initials: A
authors.lastname: Chebel
authors.forename: Martine
authors.initials: M
authors.lastname: Ffrench
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008213:Lymphocyte Activation; D053858:Metabolic Networks and Pathways; D050778:NFATC Transcription Factors / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D050778:NFATC Transcription Factors; C509186:TERT protein, human; D019098:Telomerase