title: Surface-tethered protein switches.
abstract: Protein switches are engineered fusion proteins with an input domain that recognizes and responds to an input signal and an output domain whose function is regulated by the state of the input domain. Here we demonstrate a fully functional surface tethered protein switch that offers a potential route to a universal biosensing platform.
authors.affiliation: Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Maya
authors.initials: M
authors.lastname: Zayats
authors.forename: Manu
authors.initials: M
authors.lastname: Kanwar
authors.forename: Marc
authors.initials: M
authors.lastname: Ostermeier
authors.forename: Peter C
authors.initials: PC
authors.lastname: Searson
mesh_terms: D000494:Allosteric Regulation; D015374:Biosensing Techniques; D006046:Gold / Q000737:chemistry; D055767:Immobilized Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D058619:Maltose-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D015202:Protein Engineering; D017434:Protein Structure, Tertiary; D013499:Surface Properties; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism
chemical_list: D055767:Immobilized Proteins; D058619:Maltose-Binding Proteins; D006046:Gold; D001618:beta-Lactamases