title: B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage.
abstract: The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an important predictor of prognosis in chronic lymphocytic leukaemia (CLL) since 1999. More recently, other features of the B-cell receptor, such as stereotypy, have been identified as capable of refining the prognostic potential of IGHV status in the clinical assessment of CLL patients. In this context, different genes belonging to the IGHV3 subgroup, the most frequently used subgroup in CLL, have been shown to denote disease subsets that either display a bad prognosis (i.e. IGHV3-21, IGHV3-23) or are associated with particularly good clinical outcomes, including a highly stable/indolent clinical course, even prone to spontaneous regression (i.e. IGHV3-72, IGHV3-30). The present review focuses on the molecular and biological features of CLL-expressing specific genes belonging to the IGHV3 subgroup that are known to mark disease subsets with completely different clinical courses, and may be possibly related to CLL pathogenesis via antigen and/or superantigen involvement.
authors.affiliation: Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Dal-Bo
authors.forename: Ilaria
authors.initials: I
authors.lastname: Del Giudice
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bomben
authors.forename: Daniela
authors.initials: D
authors.lastname: Capello
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Forconi
authors.forename: Luca
authors.initials: L
authors.lastname: Laurenti
authors.forename: Davide
authors.initials: D
authors.lastname: Rossi
authors.forename: Antonella
authors.initials: A
authors.lastname: Zucchetto
authors.forename: Gabriele
authors.initials: G
authors.lastname: Pozzato
authors.forename: Roberto
authors.initials: R
authors.lastname: Marasca
authors.forename: Dimitar G
authors.initials: DG
authors.lastname: Efremov
authors.forename: Anna
authors.initials: A
authors.lastname: Guarini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Del Poeta
authors.forename: Robin
authors.initials: R
authors.lastname: Foà
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gaidano
authors.forename: Valter
authors.initials: V
authors.lastname: Gattei
mesh_terms: D015870:Gene Expression; D050438:Genes, Immunoglobulin Heavy Chain; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D011379:Prognosis; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*
chemical_list: D007135:Immunoglobulin Variable Region; D011947:Receptors, Antigen, B-Cell