title: Early tagging of cortical networks is required for the formation of enduring associative memory.
abstract: Although formation and stabilization of long-lasting associative memories are thought to require time-dependent coordinated hippocampal-cortical interactions, the underlying mechanisms remain unclear. Here, we present evidence that neurons in the rat cortex must undergo a "tagging process" upon encoding to ensure the progressive hippocampal-driven rewiring of cortical networks that support remote memory storage. This process was AMPA- and N-methyl-D-aspartate receptor-dependent, information-specific, and capable of modulating remote memory persistence by affecting the temporal dynamics of hippocampal-cortical interactions. Post-learning reinforcement of the tagging process via time-limited epigenetic modifications resulted in improved remote memory retrieval. Thus, early tagging of cortical networks is a crucial neurobiological process for remote memory formation whose functional properties fit the requirements imposed by the extended time scale of systems-level memory consolidation.
authors.affiliation: Institut des Maladies Neurodégénératives, CNRS UMR 5293, Universités Bordeaux 1 et 2, Talence, France.
authors.forename: Edith
authors.initials: E
authors.lastname: Lesburguères
authors.forename: Oliviero L
authors.initials: OL
authors.lastname: Gobbo
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Alaux-Cantin
authors.forename: Anne
authors.initials: A
authors.lastname: Hambucken
authors.forename: Pierre
authors.initials: P
authors.lastname: Trifilieff
authors.forename: Bruno
authors.initials: B
authors.lastname: Bontempi
mesh_terms: D000107:Acetylation; D000818:Animals; D044127:Epigenesis, Genetic; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005518:Food Preferences; D005625:Frontal Lobe / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D007858:Learning; D008297:Male; D057567:Memory, Long-Term; D009434:Neural Pathways; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009812:Odorants; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D012054:Reinforcement, Psychology; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D018691:Excitatory Amino Acid Antagonists; D006657:Histones; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate