title: Temporal stability of defibrillation thresholds with cardiac resynchronization therapy.
abstract: BACKGROUND
  Defibrillation thresholds (DFTs) are typically stable over time among patients with implantable cardioverter-defibrillators (ICDs). However, the impact of cardiac resynchronization therapy (CRT) on DFTs has not been studied systematically.
  
  
  OBJECTIVE
  This study prospectively evaluated the effect of CRT and left ventricular (LV) chamber reverse remodeling on DFTs.
  
  
  METHODS
  This prospective, multicenter study evaluated 54 cardiac resynchronization therapy defibrillator (CRT-D) patients. Echocardiography and DFTs were performed both at implantation and at 6 months after implantation. All patients received dual-coil leads and a CRT-D pulse generator. DFTs were measured using a binary search method and tuned biphasic waveforms, where the shock pulse widths were determined by the measured shock impedance. Echocardiograms were analyzed by an independent core laboratory with a responder defined as a decrease of left ventricular end systolic volume >15%.
  
  
  RESULTS
  The study cohort was 74% male, with a mean age of 68.7 ± 10.9 years. The baseline ejection fraction was 0.245 ± 0.076, and the mean New York Heart Association class was 2.9 ± 0.4. In CRT responders (n = 32) the mean DFT was 415.6 ± 108.1 V at implantation vs. 415.6 ± 124.7 V at 6 months (P = .9), and in nonresponders (n = 19) the mean DFT was 452.6 ± 102 V at implantation vs. 447.4 ± 112.4 V at 6 months (P = .8). There was no significant change in DFT peak voltage, delivered energy, or shock impedance over time.
  
  
  CONCLUSIONS
  DFTs were unchanged at 6 months in CRT patients with or without LV chamber reverse remodeling.
authors.affiliation: Medical University of South Carolina, Charleston, South Carolina, USA. goldmr@musc.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gold
authors.forename: Amir
authors.initials: A
authors.lastname: Hedayati
authors.forename: Jamshid
authors.initials: J
authors.lastname: Alaeddini
authors.forename: John P
authors.initials: JP
authors.lastname: Payne
authors.forename: Steven
authors.initials: S
authors.lastname: Bailin
authors.forename: J J Lacy
authors.initials: JJ
authors.lastname: Sturdivant
authors.forename: Sonar
authors.initials: S
authors.lastname: Pradhan
authors.forename: Ashish L
authors.initials: AL
authors.lastname: Oza
mesh_terms: D000368:Aged; D058406:Cardiac Resynchronization Therapy / Q000379:methods; D017147:Defibrillators, Implantable; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D014693:Ventricular Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D020257:Ventricular Remodeling / Q000502:physiology*