title: Clinical and laboratory characteristics of invasive infections due to methicillin-resistant Staphylococcus aureus isolates demonstrating a vancomycin MIC of 2 micrograms per milliliter: lack of effect of heteroresistant vancomycin-intermediate S. aureus phenotype.
abstract: We describe clinical and laboratory characteristics of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections with vancomycin MICs of 2 μg/ml and compare heteroresistant-intermediate S. aureus (hVISA) to non-hVISA. Health care-associated community-onset infections were the most common and resulted in frequent complications and relapses. hVISA-infected patients were more likely to have been hospitalized in the year prior to MRSA culture.
authors.affiliation: Emory University School of Medicine, Atlanta, Georgia 30033, USA. ssatola@emory.edu
authors.forename: S W
authors.initials: SW
authors.lastname: Satola
authors.forename: F C
authors.initials: FC
authors.lastname: Lessa
authors.forename: S M
authors.initials: SM
authors.lastname: Ray
authors.forename: S N
authors.initials: SN
authors.lastname: Bulens
authors.forename: R
authors.initials: R
authors.lastname: Lynfield
authors.forename: W
authors.initials: W
authors.lastname: Schaffner
authors.forename: G
authors.initials: G
authors.lastname: Dumyati
authors.forename: J
authors.initials: J
authors.lastname: Nadle
authors.forename: J B
authors.initials: JB
authors.lastname: Patel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000382:microbiology / Q000473:pathology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D008875:Middle Aged; D012008:Recurrence; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000473:pathology*; D016896:Treatment Outcome; D020713:Vancomycin Resistance; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents