title: Photodynamic therapy for variant central serous chorioretinopathy: efficacy and side effects.
abstract: BACKGROUND
  Retinal pigment epithelial detachment (PED) is a recognised associated finding in central serous chorioretinopathy (CSC). We report our experience in treating patients using photodynamic therapy (PDT) in a variant of chronic CSC that presents with only an isolated PED. We present long-term follow-up data and novel observations on the pattern of retinal pigment epithelium (RPE) changes seen after treatment.
  
  
  METHODS
  Retrospective case series.
  
  
  CONCLUSIONS
  CSC with subfoveal PED can be associated with a poor visual prognosis especially when the PED becomes chronic. PDT has been used to treat typical CSC with good outcomes. Three eyes in 3 patients were successfully treated with PDT, using the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy protocol. However, marked RPE disturbance was observed after treatment directly overlying the areas of brisk choroidal hyperpermeability.
authors.affiliation: St. Thomas' Hospital, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Gupta
authors.forename: M D
authors.initials: MD
authors.lastname: Mohamed
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011166:Porphyrins / Q000627:therapeutic use*; D055213:Retinal Pigment Epithelium / Q000187:drug effects / Q000473:pathology; D041623:Tomography, Optical Coherence; D000077362:Verteporfin; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin