title: Molecularly imprinted polymer-based potentiometric sensor for 2-aminopyridine as a potential impurity in piroxicam.
abstract: A molecularly imprinted polymer-based potentiometric sensor was fabricated for determination of 2-aminopyridine (2-AP). The electroactive component is the 2-APH(+) . To form this specie the determination is carried out in a bufferic solution at pH 4.5 in which 2-AP is prevalently monoprotonated. Under these conditions, the membrane potential, increases with 2-AP concentration over a wide range of concentration (5 µM to 100 mM) with a near Nernstian response of 54.1 mV/decade and detection limit of 2.0 µM. The response time is less than 5 s and the sensor can be used for more than 3 months without any significant divergence in response. The selectivity coefficients of the proposed sensor were evaluated and exhibited good selectivity to 2-AP with respect to the electrode based on a non-imprinted polymer. The utility of the sensor was successfully tested by examining of 2-AP in piroxicam (PX) as a potential impurity.
authors.affiliation: Department of Chemistry, Faculty of Science, Imam Hossein University, Babaee freeway, 16597,Tehran, Iran. mnajafi2000@yahoo.com
authors.forename: Mostafa
authors.initials: M
authors.lastname: Najafi
authors.forename: Rasoul
authors.initials: R
authors.lastname: Mehdipour
mesh_terms: D000631:Aminopyridines / Q000032:analysis* / Q000737:chemistry; D001665:Binding Sites; D004340:Drug Contamination; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D008564:Membrane Potentials; D008567:Membranes, Artificial; D054802:Molecular Imprinting / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010894:Piroxicam / Q000737:chemistry*; D010968:Plasticizers / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D011199:Potentiometry; D015203:Reproducibility of Results; D013055:Spectrophotometry, Infrared; D013997:Time Factors
chemical_list: D000631:Aminopyridines; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D010968:Plasticizers; D011109:Polymethacrylic Acids; D010894:Piroxicam; C030613:polymethacrylic acid; D011143:Polyvinyl Chloride; C032439:alpha-aminopyridine