title: Innate and adaptive resistance of Indonesian Thin Tail sheep to liver fluke: a comparative analysis of Fasciola gigantica and Fasciola hepatica infection.
abstract: In the current study, three independent trials directly compared Fasciola gigantica and Fasciola hepatica infection of ITT sheep. In all trials, F. hepatica infection resulted in higher worm burden recoveries and greater physiological damage to ITT sheep. Developmental differences of the two Fasciola species were also observed during the first twelve weeks of a primary infection, where the migration and growth of F. hepatica was more rapid than F. gigantica. Various immunological blood parameters were measured and indicated similar kinetics in the humoral and cellular responses during the time course of infection with each Fasciola species. In contrast to F. hepatica infection, we demonstrate an innate and adaptive comparative ability of ITT sheep to resist the early stages of infection with F. gigantica infection. Unraveling the mechanisms leading to this differential resistance may potentially lead to new methods for the control of fasciolosis and other human liver flukes.
authors.affiliation: Biotechnology Research Laboratories, School of Biomedical Sciences, Monash University, Clayton, Melbourne, VIC 3800, Australia. Jill.Pleasance@monash.edu
authors.forename: Jill
authors.initials: J
authors.lastname: Pleasance
authors.forename: Herman W
authors.initials: HW
authors.lastname: Raadsma
authors.forename: S E
authors.initials: SE
authors.lastname: Estuningsih
authors.forename: S
authors.initials: S
authors.lastname: Widjajanti
authors.forename: Els
authors.initials: E
authors.lastname: Meeusen
authors.forename: David
authors.initials: D
authors.lastname: Piedrafita
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D001772:Blood Cell Count / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005210:Fasciola hepatica / Q000276:immunology*; D005211:Fascioliasis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006651:Histocytochemistry; D008297:Male; D011897:Random Allocation; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology*; D018709:Statistics, Nonparametric; D013785:Thailand
chemical_list: D000909:Antibodies, Helminth