title: Efficacy and safety of Derris scandens Benth extracts in patients with knee osteoarthritis.
abstract: OBJECTIVE
  The objectives of this study were to determine the efficacy and safety of Derris scandens Benth extracts in pain reduction and functional improvement in patients with knee osteoarthritis (OA).
  
  
  METHODS
  This was a prospective, randomized, controlled trial, single-blinded (assessor).
  
  
  METHODS
  The study was conducted at the Rehabilitation Medicine Department, Siriraj Hospital.
  
  
  METHODS
  One hundred and seven (107) patients with primary OA knee who had pain score of ≥ 5 were recruited.
  
  
  METHODS
  Patients were randomized to receive naproxen 500 mg/day or Derris 800 mg/day for 4 weeks.
  
  
  METHODS
  Western Ontario McMaster Osteoarthritis Index (WOMAC) scores and 6-minute walking distance were the outcome measurements.
  
  
  RESULTS
  Fifty-five (55) and 52 patients were randomized to Derris and naproxen groups, respectively. The mean differences of all WOMAC scores between 2 groups at week 4 adjusted by week 0 were within ± 1 point. The mean scores of the aforementioned outcomes at weeks 0, 2, and 4 were significantly improved compared to the baseline values. There was no difference of WOMAC scores between groups. The gastrointestinal irritation and dyspepsia were observed more often in the naproxen than in the Derris group.
  
  
  CONCLUSIONS
  Derris scandens Benth extracts were efficacious and safe for the treatment of knee OA.
authors.affiliation: Department of Rehabilitation Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sivkp@mahidol.ac.th
authors.forename: Vilai
authors.initials: V
authors.lastname: Kuptniratsaikul
authors.forename: Theerawut
authors.initials: T
authors.lastname: Pinthong
authors.forename: Malee
authors.initials: M
authors.lastname: Bunjob
authors.forename: Sunee
authors.initials: S
authors.lastname: Thanakhumtorn
authors.forename: Pornsiri
authors.initials: P
authors.lastname: Chinswangwatanakul
authors.forename: Visanu
authors.initials: V
authors.lastname: Thamlikitkul
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D029866:Derris; D005260:Female; D006801:Humans; D007717:Knee / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D009288:Naproxen / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000473:pathology; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016037:Single-Blind Method; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D009288:Naproxen