title: Plasma reactive carbonyl species: Potential risk factor for hypertension.
abstract: To study the role of oxidative stress in hypertension and pre-hypertension, this study analysed plasma levels of reactive carbonyl species (RCS) in 1204 Chinese Han adults. Results showed a statistically significant positive correlation (p < 0.001) between blood pressure and plasma RCS levels with or without being adjusted for covariates. Multivariate-adjusted odds ratio (OR) illustrated that, compared with the lowest quartile of plasma RCS levels, the highest quartile subjects had a 59% and a 130% increase in the risk for developing pre-hypertension and hypertension, respectively. The multi-interaction analysis manifested that the underlying mechanism of the increase of hypertensive risk or pre-hypertensive risk by overweight and unhealthy lifestyles might, at least in part, be through oxidative stress. In conclusion, these findings suggest that oxidative stress, as indicated by plasma RCS levels, are not the necessary consequence of pre-hypertension or hypertension, but reliable risk factors for developing pre-hypertension or hypertension in Chinese Han adults.
authors.affiliation: The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, Hunan, PR China.
authors.forename: Keke
authors.initials: K
authors.lastname: Chen
authors.forename: Fuxia
authors.initials: F
authors.lastname: Xie
authors.forename: Shenglin
authors.initials: S
authors.lastname: Liu
authors.forename: Guolin
authors.initials: G
authors.lastname: Li
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Chen
authors.forename: Wang
authors.initials: W
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Hu
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Dazhong
authors.initials: D
authors.lastname: Yin
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018384:Oxidative Stress; D058246:Prehypertension / Q000097:blood*; D050050:Protein Carbonylation; D012307:Risk Factors; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances