title: Atypical Gianotti-Crosti syndrome in two HIV and hepatitis B co-infected adults.
abstract: We describe an atypical Gianotti-Crosti syndrome in two 43-year-old, unrelated adult male patients with coexistent hepatitis B and HIV infection. Both cases shared many of the hallmarks of childhood Gianotti-Crosti syndrome. We believe that this is the first report in the literature of a Gianotti-Crosti syndrome-like paraviral eruption in HIV and hepatitis B positive adults. The protracted duration of the exanthem, of between 4 and 25 months, may have been related to their underlying HIV infection. Immunoperoxidase studies suggest the presence of hepatitis B surface antigens within the vessels of both lesional and perilesional skin, providing further support for the proposed, immune-mediated pathogenesis of paraviral eruptions.
authors.affiliation: Skin and Cancer Foundation, New South Wales, Australia.
authors.forename: Raymond
authors.initials: R
authors.lastname: Cocciolone
authors.forename: Adrienne
authors.initials: A
authors.lastname: Morey
authors.forename: Patrycja
authors.initials: P
authors.lastname: Panasiuk
authors.forename: Margot J
authors.initials: MJ
authors.lastname: Whitfeld
mesh_terms: D000169:Acrodermatitis / Q000150:complications* / Q000473:pathology*; D000328:Adult; D015658:HIV Infections / Q000150:complications*; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008297:Male