title: Branching out with DNA helicases.
abstract: The proper resolution of branched DNA molecules, which arise during processes such as DNA replication, DNA repair, and transcription, is critical for the maintenance of the genome. Disruption of this process can lead to genome instability and cancer progression. In this review, we describe recent progress on several interesting and biologically important enzymes that act upon different types of branched DNA substrates.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA. timur_yusufzai@dfci.harvard.edu
authors.forename: Timur
authors.initials: T
authors.lastname: Yusufzai
authors.forename: James T
authors.initials: JT
authors.lastname: Kadonaga
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D013379:Substrate Specificity
chemical_list: D004247:DNA; D004265:DNA Helicases