title: Phylogenetic analysis of human rotavirus in Myanmar: detection of Indian-Bangladeshi G1/G2 lineages, Chinese G3 lineage and OP354-like P[8] lineage (P[8]b subtype).
abstract: As a first phylogenetic study of human rotavirus in Myanmar, VP7 and VP8* gene sequences of 5 group A human rotaviruses detected in children in Yangon City were determined and analyzed for their relatedness to rotavirus strains reported in other countries. VP7 genes of the two G1P[8] strains and the two G2P[4] strains clustered phylogenetically with those of Indian-Bangladeshi lineages with extremely high sequence identities. In contrast, a G3P[8] strain exhibited a close relatedness of VP7 gene to G3 rotaviruses currently prevailing in China, which had been referred to as a new variant G3 rotavirus. While VP8* genes of P[4] and P[8] strains clustered with those of Indian and Bangladeshi strains, only the G1 strain was grouped into a rare P[8] subtype, ie, P[8]b (OP354-like P[8]) with close relatedness to the P[8]b strains in eastern India and Thailand. The coexistence in Myanmar of G1/G2 and G3 rotaviruses, which are virtually identical to those predominating in India/Bangladesh and China, respectively, suggests the spread of these predominant rotaviruses from the two regions into Myanmar.
authors.affiliation: Virology Section, National Health Laboratory, Yangon, Myanmar.
authors.lastname: Meiji-Soe-Aung
authors.lastname: Tin-Sabai-Aung
authors.lastname: Khin-Yi-Oo
authors.lastname: Ne-Win
authors.forename: Souvik
authors.initials: S
authors.lastname: Ghosh
authors.forename: Dai
authors.initials: D
authors.lastname: Yamamoto
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Kobayashi
mesh_terms: D000956:Antigens, Viral / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D002648:Child; D005838:Genotype; D006801:Humans; D002052:Myanmar; D010802:Phylogeny; D016601:RNA-Binding Proteins / Q000235:genetics*; D012401:Rotavirus / Q000145:classification* / Q000235:genetics; D017361:Viral Nonstructural Proteins / Q000235:genetics*
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; D016601:RNA-Binding Proteins; C050779:VP7 protein, Rotavirus; D017361:Viral Nonstructural Proteins; C079234:NS35 protein, rotavirus