title: Expression of endometrial protein markers in infertile women and the association with subsequent in vitro fertilization outcome.
abstract: Endometrial biopsies were performed during the luteal phase just before an IVF cycle in 104 infertile women, and immunohistochemical staining was performed to investigate expression patterns of hCG-LH receptor, leukemia-inhibitory factor, macrophage colony-stimulating factor, HOXA-10, vascular endothelial growth factor A, and their relation to subsequent IVF pregnancy. Only glandular expression of vascular endothelial growth factor A in early luteal endometrium was significantly higher in the pregnant group compared with the nonpregnant group (6.0 ± 3.9 vs. 2.9 ± 3.4) and thus could be a predicting marker for subsequent IVF pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, MizMedi Hospital, Seoul, South Korea.
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Seo
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Jee
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D016022:Case-Control Studies; D004717:Endometrium / Q000737:chemistry* / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007246:Infertility / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D053605:Leukemia Inhibitory Factor / Q000032:analysis; D008183:Luteal Phase / Q000378:metabolism; D016173:Macrophage Colony-Stimulating Factor / Q000032:analysis; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D011974:Receptors, LH / Q000032:analysis; D056910:Republic of Korea; D016896:Treatment Outcome; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
chemical_list: D015415:Biomarkers; D000080905:Homeobox A10 Proteins; D018398:Homeodomain Proteins; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D011974:Receptors, LH; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C069634:HOXA10 protein, human; D016173:Macrophage Colony-Stimulating Factor