title: Sequence variations in the FII, FV, F13A1, FGB and PAI-1 genes are associated with differences in myocardial perfusion.
abstract: OBJECTIVE
  Coronary artery disease (CAD) is a significant cause of morbidity and mortality in modern societies. The association between genetic markers and CAD is still poorly understood. In this study, we evaluated the effect of five genetic variants: Factor V Leiden (FV:c.1691G>A) (rs6025), Factor II prothrombin (FII:c.20210G>A; rs1799963), plasminogen activator inhibitor 1 (PAI-1) -675(4G/5G; SERPINE1:g.4329_4330insG; rs34857375), β-fibrinogen -455G>A (FGB:c.4577G>A; rs1800790) and Factor XIII (F13A1:c.103G>T; rs5985) on myocardial perfusion.
  
  
  METHODS
  We examined 523 patients using exercise-rest myocardial perfusion single photon emission computed tomography, where the summed stress score (SSS), summed rest score and summed difference score (SDS) indexes, were calculated. In order to examine the independent prognostic ability of genotype on SSS and SDS, multiple linear regression models were used.
  
  
  RESULTS
  It was found that Factor V Leiden, Factor XIII, β-fibrinogen and PAI-1 genotypes were independent prognostic predictors of SSS and SDS with Factor XIII exhibiting the strongest association. Moreover, Factor II prothrombin proved an independent prognostic predictor of SSS.
  
  
  CONCLUSIONS
  Our study provides the first evidence of an association between these polymorphisms and myocardial perfusion, suggesting that the process of coronary artery disease and also patients' prognosis, may be modified by the FV:c.1691G>A, FII:c.20210G>A, PAI-1 -675 (4G/5G), β-fibrinogen FGB:c.4577G>A and F13A1:c.103G>T genotypes.
authors.affiliation: Department of Biology & Genetics, University of Thessalia, Larissa, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Satra
authors.forename: Maria
authors.initials: M
authors.lastname: Samara
authors.forename: Greta
authors.initials: G
authors.lastname: Wozniak
authors.forename: Chara
authors.initials: C
authors.lastname: Tzavara
authors.forename: Angelos
authors.initials: A
authors.lastname: Kontos
authors.forename: Varvara
authors.initials: V
authors.lastname: Valotassiou
authors.forename: Nikolaos K
authors.initials: NK
authors.lastname: Vamvakopoulos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tsougos
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Aleporou-Marinou
authors.forename: George P
authors.initials: GP
authors.lastname: Patrinos
authors.forename: Panagoula
authors.initials: P
authors.lastname: Kollia
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgoulias
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics* / Q000473:pathology*; D005080:Exercise Test; D005165:Factor V / Q000235:genetics; D005176:Factor XIII / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000235:genetics; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011516:Prothrombin / Q000235:genetics
chemical_list: D000941:Antigens; D017395:Plasminogen Activator Inhibitor 1; C055042:factor II clotting antigen; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D005340:Fibrinogen; D005176:Factor XIII