title: [Observation on the characteristics and influencing factors of cardio-pulmonary function in patients with lung cancer].
abstract: BACKGROUND
  To explore the characteristics of exercise cardio-pulmonary function and its possible influencing factors in patients with lung cancer.
  
  
  METHODS
  The pulmonary function, ECG and exercise cardio-pulmonary function were measured in 198 patients with lung cancer and 20 healthy controls.
  
  
  RESULTS
  1. Compared with healthy group, VO₂%P, VO₂/kg, AT, VO₂/HR%, VE and VT/VC significantly decreased in lung cancer patients with normal resting pulmonary ventilation, however, BR remarkably increased (P < 0.05 or P < 0.01). 2. In patients with normal resting pulmonary ventilation, there was no significant difference of exercise cardio-pulmonary function between the central and peripheral lung cancer groups. 3. The exercise cardio-pulmonary function was closely related to the TNM stages (P < 0.05 or P < 0.01). 4. W%, VO₂%P , AT and VO₂/HR% in patients with great vessel invasion were remarkably lower than those without great vessel invasion (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  The results suggest that exercise ventilation is impaired in lung cancer patients with normal resting ventilation. And the decrease of exercise cardio-pulmonary function may be related to TNM stage and to great vessel involvement.
authors.affiliation: Department of Heart Lung Function, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, P.R.China.
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Guohong
authors.initials: G
authors.lastname: Zhang
authors.forename: Guixin
authors.initials: G
authors.lastname: Sun
authors.forename: Zhiru
authors.initials: Z
authors.lastname: Wang
authors.forename: Hongyun
authors.initials: H
authors.lastname: Ruan
authors.forename: Botao
authors.initials: B
authors.lastname: Dong