title: [The effect on angiogenesis of endometrium after transcervical resection of polyp].
abstract: OBJECTIVE To investigate angiogenesis of endometrium after transcervical resection of endometrial polyp.
  
  
  METHODS
  Twenty five patients were chosen whose final diagnosises are EP. They all conceived the treatment of transcervical resection of polyp in 5-7 days after the end of menstruation. The tissue of EP were resected in the operation were collected as the first group. The second group included 20 patients who conceived the treatment of transcervical resection of polyp, in the 1-3 months after the operation,we collected their endometrium located in the extent of rescection samely in one day of 5-7 days after the ending of their menstruations. 25 endometrium in proliferative stage were collected as the third group. expression of vascular endothelial growth factor (VEGF) and CD34 were detected by immunohistochemical methods. We counted the microvessel density (MVD) depending on microscope, and detected integrated optical density (IOD) of VEGF by using special image analysis software (image pro plus 4.5).
  
  
  RESULTS
  IOD of VEGF expression and MVD of the first group were significantly higher than that of the second and the third group (P > 0.05). IOD of VEGF expression and MVD were both same in the second and third group (P > 0.05).
  
  
  CONCLUSIONS
  Significance of the angiogenesis in the formation of EP was obvious. Expression of VEGF and MVD could be degraded in someone's local endometrium after they conceived the treatment of TCRP. These results were the molecular mechanisms how TCRP could cure EP successfully.
authors.affiliation: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Chengdu, Chengdu 610015, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
authors.forename: Yu-jue
authors.initials: YJ
authors.lastname: Wang
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Gao
mesh_terms: D000328:Adult; D004717:Endometrium / Q000098:blood supply*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D009389:Neovascularization, Pathologic; D011127:Polyps / Q000503:physiopathology / Q000601:surgery*; D014591:Uterine Diseases / Q000503:physiopathology* / Q000601:surgery; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D055815:Young Adult
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A