title: A"Proteoglycan targeting strategy" for the scintigraphic imaging and monitoring of the swarm rat chondrosarcoma orthotopic model.
abstract: Our lab developed (99m)Tc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of (99m)Tc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). (99m)Tc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant (99m)Tc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. (99m)Tc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.
authors.affiliation: INSERM (UMR 990) Université d'Auvergne, rue Montalembert, BP 184, 63005 Clermont-Ferrand Cédex, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Peyrode
authors.forename: François
authors.initials: F
authors.lastname: Gouin
authors.forename: Aurélien
authors.initials: A
authors.lastname: Vidal
authors.forename: Philippe
authors.initials: P
authors.lastname: Auzeloux
authors.forename: Sophie
authors.initials: S
authors.lastname: Besse
authors.forename: Marie-Mélanie
authors.initials: MM
authors.lastname: Dauplat
authors.forename: Serge
authors.initials: S
authors.lastname: Askienazy
authors.forename: Dominique
authors.initials: D
authors.lastname: Heymann
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Chezal
authors.forename: Françoise
authors.initials: F
authors.lastname: Redini
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Miot-Noirault