title: Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy.
abstract: TgTauP301L mice that overexpress the mutant human tauP301L present in FTDP-17 reproduce neurofibrillary tangles (NFTs), neuronal cell losses, memory disturbance, and substantial phenotypic variation. To demonstrate factors responsible for NFT formation and neuronal cell losses, sets of TgTauP301L for comparison with or without NFTs and neuronal cell losses were studied with oligonucleotide microarrays. Gene expressions were altered in biological pathways, including oxidative stress, apoptosis, mitochondrial fatty acid betaoxidation, inflammatory response pathway, and complement and coagulation cascade pathways. Among 24 altered genes, increased levels of apolipoprotein D (ApoD) and neuronal PAS domain protein 4 (Npas4) and decreased levels of doublecortin (DCX) and potassium channel, voltage-gated, shaker-related subfamily, β member 1 (Kcnab1) were found in the TgTauP301L with NFTs and neuronal cell losses, Alzheimer's brains, and tauopathy brains. Thus, many biological pathways and novel molecules are associated with NFT formation and neuronal cell losses in tauopathy brains.
authors.affiliation: Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Wakasaya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawarabayashi
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Yamamoto-Watanabe
authors.forename: Ayumi
authors.initials: A
authors.lastname: Takamura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kurata
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Murakami
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Yamada
authors.forename: Koichi
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sasaki
authors.forename: David
authors.initials: D
authors.lastname: Westaway
authors.forename: Peter St George
authors.initials: PS
authors.lastname: Hyslop
authors.forename: Etsuro
authors.initials: E
authors.lastname: Matsubara
authors.forename: Mikio
authors.initials: M
authors.lastname: Shoji
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015153:Blotting, Western; D000089662:Doublecortin Protein; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D024801:Tauopathies / Q000235:genetics / Q000378:metabolism* / Q000473:pathology