title: A case of recovery from canine destructive cholangitis in a Miniature Dachshund.
abstract: A 7-year-old Miniature Dachshund presented with severe chronic jaundice and elevated liver enzymes. Destructive cholangitis was diagnosed according to histopathological findings of remarkable ductopenia with inflammatory infiltrates and fibrosis in the portal areas. Supportive therapy with prednisolone, high-dose ursodeoxycholic acid, human placental extract and antibiotics was tried, and the patient showed recovery of clinical signs 3 months after diagnosis. A second liver biopsy was performed about 1 year after initial diagnosis, and bile duct restoration was confirmed with continuous inflammation around portal areas and inside the lobules. Although we could not determine which treatment was effective in this case, destructive cholangitis in dogs may be recoverable with long-term supportive therapies.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Osumi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kanemoto
authors.forename: Ko
authors.initials: K
authors.lastname: Nakashima
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Ayako
authors.initials: A
authors.lastname: Karasawa
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Fujino
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy / Q000662:veterinary; D002761:Cholangitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D006651:Histocytochemistry / Q000662:veterinary; D008297:Male; D010924:Placental Extracts / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D014463:Ultrasonography; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D010924:Placental Extracts; D014580:Ursodeoxycholic Acid; D011239:Prednisolone