title: Idiopathic cytopenia of undetermined significance and the minimal criteria for a diagnosis of myelodysplastic syndrome.
abstract: A bone marrow examination in a young woman with anemia and β-thalassemia trait showed dyserythropoiesis in less than 10% of erythroblasts without other myelodysplastic changes, and cytogenetic analysis revealed trisomy of chromosome 8. Although she did not fulfill the current World Health Organization (WHO) criteria for diagnosis of a myelodysplastic syndrome, her acquired bone marrow disorder behaved as such, and she later developed acute myeloid leukemia.
authors.affiliation: Department of Haematology, St Mary's Hospital, Praed Street, London, UK.
authors.forename: Jiri
authors.initials: J
authors.lastname: Pavlu
authors.forename: Julie
authors.initials: J
authors.lastname: Emmerson
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: Marks
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Bain
mesh_terms: D020732:Cytogenetic Analysis; D003937:Diagnosis, Differential; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D010198:Pancytopenia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D055815:Young Adult