title: Autoimmune clustering: sweet syndrome, Hashimoto thyroiditis, and psoriasis.
abstract: Acute febrile neutrophilic dermatosis (AFND; Sweet syndrome) is characterized by a constellation of symptoms and findings: fever, neutrophilia, and tender erythematous skin lesions that typically show an upper dermal infiltrate of mature neutrophils. Whereas some cases are idiopathic, others have been associated with a variety of disorders. In this report, we describe the occurrence of AFND with chronic lymphocytic thyroiditis (Hashimoto thyroiditis) and preexisting psoriasis. This is the first case report of the association of chronic lymphocytic thyroiditis with AFND from the United States and only the third reported in the world's literature. Because the coexistence of these disorders is rare, an underlying common pathogenic mechanism is a possibility. We postulate this to be CD4(+) T-cell dysfunction.
authors.affiliation: Division of General Internal Medicine, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. mskhan@uams.edu
authors.forename: Mohammad
authors.initials: M
authors.lastname: Saeed
authors.forename: Grace E
authors.initials: GE
authors.lastname: Brown
authors.forename: Abhishek
authors.initials: A
authors.lastname: Agarwal
authors.forename: Donna
authors.initials: D
authors.lastname: Pellowski
authors.forename: Jennifer
authors.initials: J
authors.lastname: Jacks
authors.forename: Hazel K
authors.initials: HK
authors.lastname: Liverett
authors.forename: Keyur S
authors.initials: KS
authors.lastname: Vyas
mesh_terms: D015551:Autoimmunity / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D016000:Cluster Analysis; D015897:Comorbidity; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D050031:Hashimoto Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D016463:Sweet Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011241:Prednisone