title: Benzyl radical addition reaction through the homolytic cleavage of a benzylic C-H bond.
abstract: Direct generation of a benzyl radical by C-H bond activation of toluenes and the addition reaction of the resulting radical to an electron deficient olefin were developed. The reaction of dimethyl fumarate with toluene in the presence of Et(3)B as a radical initiator at reflux afforded 2-benzylsuccinic acid dimethyl ester in good yield.
authors.affiliation: Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda
authors.forename: Eiko
authors.initials: E
authors.lastname: Kondoh
authors.forename: Yuta
authors.initials: Y
authors.lastname: Ito
authors.forename: Hiroko
authors.initials: H
authors.lastname: Shono
authors.forename: Maiko
authors.initials: M
authors.lastname: Kakiuchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ichii
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kimura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Takeaki
authors.initials: T
authors.lastname: Naito
authors.forename: Okiko
authors.initials: O
authors.lastname: Miyata
mesh_terms: D000475:Alkenes / Q000737:chemistry; D001593:Benzyl Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D001593:Benzyl Compounds; D005609:Free Radicals; D002244:Carbon; D006859:Hydrogen