title: Mild cognitive impairment subcategories depend on the source of norms.
abstract: The diagnosis of mild cognitive impairment (MCI) entails evidence of objective cognitive loss using neuropsychological measures. In this study, we examined whether the presence and degree of objective cognitive impairment varied according to the use of published versus local norms. We also varied the cutoff scores at which impairment was recognized and examined whether this altered inclusion in MCI subcategories. We found that the use of different comparison normative groups altered the subcategory diagnoses, especially when the cutoff score for impairment was conservative. In general, local norms were more stringent than published norms. We discuss the implications of these results for MCI diagnosis and categorization.
authors.affiliation: Bloomfield Centre for Research on Aging, Lady Davis Institute of Medical Research, Sir B. Davis Jewish General Hospital, Montreal, QC, Canada.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Arsenault-Lapierre
authors.forename: Victor
authors.initials: V
authors.lastname: Whitehead
authors.forename: Sylvie
authors.initials: S
authors.lastname: Belleville
authors.forename: Fadi
authors.initials: F
authors.lastname: Massoud
authors.forename: Howard
authors.initials: H
authors.lastname: Bergman
authors.forename: Howard
authors.initials: H
authors.lastname: Chertkow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000145:classification* / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012016:Reference Values