title: Successful second autologous peripheral blood stem cell transplantation conditioned with total body irradiation for progressive neuroblastoma after recurrence.
abstract: A girl with recurrent neuroblastoma was successfully treated with second autologous stem cell transplantation (SCT) conditioned with total body irradiation (TBI). This patient was diagnosed as stage IV neuroblastoma at the age of 18 months. Pathological finding was stroma-poor unfavorable histology and amplification of MYCN gene was extremely high (153 copies). In spite of autologous SCT with non-TBI regimen in the status of disease-free, neuroblastoma relapsed at the primary site 6 months later. Second autologous SCT conditioned with TBI and melphalan was performed although the tumor was progressive. Over 3 years after second SCT, she has been well with no evidence of further recurrence of neuroblastoma, but she was complicated with permanent atrophy of left kidney. TBI might be effective for relapsed neuroblastoma who previously received SCT with non-TBI regimen.
authors.affiliation: Department of Pediatrics, Tokai University School of Medicine, 143 Shimokasuya Isehara- City, Kanagawa 259-1193, Japan. tsumori@is.icc.u-tokai.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Morimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsufuji
authors.forename: Kinji
authors.initials: K
authors.lastname: Yokomori
authors.forename: Ryohta
authors.initials: R
authors.lastname: Hosoya
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D019172:Transplantation Conditioning / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000379:methods*