title: New angucycline C-glycosides from Streptomyces sp. RI33.
abstract: In the course of our screening program for anticancer agents from natural sources, five new angucyclines, JBIR-90 (1), -116 (2), -91 (3), -92 (4) and -93 (5), were isolated from the fermentation broth of Streptomyces sp. RI33. The structures of 1-5 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compounds 2-4 showed cytotoxic activities against malignant pleural mesothelioma cells at IC(50) values of 20-50 μM.
authors.affiliation: Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), Tokyo, Japan.
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Ueda
authors.forename: Miho
authors.initials: M
authors.lastname: Izumikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Mukai
authors.forename: Aya
authors.initials: A
authors.lastname: Nagai
authors.forename: Ji-Hwan
authors.initials: JH
authors.lastname: Hwang
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005285:Fermentation; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008654:Mesothelioma / Q000188:drug therapy* / Q000473:pathology; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides