title: The effect of intrafollicular IGF 1 and IGFBP 3 on IVF outcome in patients using different gonadotropins: a prospective study.
abstract: OBJECTIVE
  To investigate follicular fluid IGF 1, IGFBP 3 and their effects on IVF outcome in patients using different gonadotropins.
  
  
  METHODS
  This prospective study was performed among 92 IVF patients who were categorized according to IVF pregnancy outcome. Two groups were formed as Group 1 : pregnant, Group 2: non pregnant.
  
  
  RESULTS
  Follicular IGF 1 and IGFBP 3 levels were not different between the two groups. There were negative correlations between follicular IGF 1 and age, gonadotropin dose, embryo numbers in all patients and group 2, but there were no correlations between IGF1 and these parameters in group 1. Although IGFBP 3 levels were not different in patients using rec FSH or HMG, IGF 1 were higher in patients treated by rec FSH compared to patient using HMG. When the groups using rec FSH or HMG were analyzed according to pregnancy rate, there were no differences in IGF 1 levels.
  
  
  CONCLUSIONS
  Follicular IGF 1, IGFBP 3 do not predict clinical IVF outcome regardless of the different gonadotropin preparations.
authors.affiliation: Department of Infertility, Zekai Tahir Burak Women's Health Research and Education Hospital, Guvenlik cad 54/7, Asagi Ayranci, Ankara, Turkey.
authors.forename: Gulay
authors.initials: G
authors.lastname: Genc
authors.forename: Nafiye
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.forename: Muammer
authors.initials: M
authors.lastname: Dogan
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D015571:Follicular Fluid / Q000378:metabolism; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D009865:Oocytes / Q000378:metabolism; D010062:Ovulation Induction; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D005640:Follicle Stimulating Hormone