title: Malignant granular cell tumor in the gluteal region with unusual pathologic features.
abstract: Malignant granular cell tumors (MGCTs) are very rare soft tissue sarcomas. Definite criteria for pathologic diagnosis and the optimal treatment strategy have not been fully established. Here, we describe a 76-year-old woman with a huge MGCT in the right gluteal region, who developed a local recurrence and died from that tumor 14 months after undergoing an operation for the primary tumor. Although microscopic examination revealed that round and granular tumor cells staining for S-100 protein were dominant, components of the spindle cell sarcoma reacting with alpha smooth muscle actin were partially observed. MGCT is believed to originate from Schwann cells; however, pathologic findings in our case showed both Schwannian and non-Schwannian features. This is the first report on MGCT with these 2 features appearing simultaneously.
authors.affiliation: Department of Surgery, Tama-Nagayama Hospital, Nippon Medical School, Tama, Tokyo, Japan. seiji@nms.ac.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Shotaro
authors.initials: S
authors.lastname: Maeda
authors.forename: Koji
authors.initials: K
authors.lastname: Sasajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsutani
authors.forename: Aimin
authors.initials: A
authors.lastname: Liu
authors.forename: Masaru
authors.initials: M
authors.lastname: Hosone
authors.forename: Masataka
authors.initials: M
authors.lastname: Tanno
authors.forename: Eiji
authors.initials: E
authors.lastname: Uchida
mesh_terms: D000368:Aged; D002081:Buttocks / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000601:surgery*