title: Overall survival in BRCA-associated ovarian cancer: case-control study of an Italian series.
abstract: About 10% of all ovarian cancers are due to BRCA 1 and/or BRCA 2 mutations. Some studies have shown that patients belonging to this group have a better survival compared to sporadic groups but data are still inconclusive. The aim of this study was to investigate overall survival in patients with ovarian cancer and germ-line mutations in the BRCA1/2 genes in comparison to high-risk patients, defined as patients with ovarian cancer and a strong family history of breast and ovarian cancer, but who tested negative for the BRCA mutation. We collected all the clinical features and did follow-up. The two groups showed similar characteristics concerning age at diagnosis, histological type and stage. Grade 3 was more frequent in the BRCA group. Survival data did not show any advantage for the BRCA mutated group.
authors.affiliation: Department of Medical Science, Oncology-Haematology Department, Mirano/Venice, Veneto Oncology Istitute I.O.V., Padova, Italy. grazia.artioli@yahoo.it
authors.forename: G
authors.initials: G
authors.lastname: Artioli
authors.forename: L
authors.initials: L
authors.lastname: Borgato
authors.forename: A
authors.initials: A
authors.lastname: Cappetta
authors.forename: J
authors.initials: J
authors.lastname: Wabersich
authors.forename: S
authors.initials: S
authors.lastname: Mocellin
authors.forename: M
authors.initials: M
authors.lastname: Dalla Palma
authors.forename: O
authors.initials: O
authors.lastname: Nicoletto
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007558:Italy; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D024682:BRCA2 Protein