title: Bipolar disorder susceptibility region on chromosome 3q29 not confirmed in a case-control association study.
abstract: OBJECTIVE
  We identified a bipolar disorder (BPD) susceptibility region on chromosome 3q29 in a genome-wide linkage scan (Bailer et al. 2002 (Biol Psychiatry 52: 40), NPL-score 4.09) and follow-up linkage analysis (Schosser et al. 2004 (J Psychiatr Res 38(3): 357), NPL-scores >3 with five markers). These findings were supported by further fine-mapping of this region (Schosser et al. 2007 (Eur Neuropsychopharmacol 17(6-7): 501)), finding NPL-scores >3.9 with SNPs (single nucleotide polymorphisms) spanning a region of 3.46 Mbp in BPD families. Since genetic association studies are more powerful than linkage studies for detecting susceptibility genes of small effect size, we aimed to replicate these findings in an independent case-control sample collected in London (UK) and Vienna (Austria).
  
  
  METHODS
  A total of 51 SNPs were genotyped using Sequenom MassARRAY(®) iPLEX Gold and tested for association in a sample of 526 cases suffering from DSM-IV and/or ICD-10 diagnosis of BPD and 691 controls.
  
  
  RESULTS
  No genotypic and/or allelic association, as well as no haplotypic association, was found for any SNP after multiple testing correction.
  
  
  CONCLUSIONS
  However, we cannot exclude the possibility that our sample might not have the power to detect rare variants associated with susceptibility to BPD.
authors.affiliation: Department of Psychiatry and Psychotherapy, Medical University Vienna, Austria. alexandra.schosser@meduniwien.ac.at
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schosser
authors.forename: Monika
authors.initials: M
authors.lastname: Schloegelhofer
authors.forename: Karoline
authors.initials: K
authors.lastname: Fuchs
authors.forename: Mirjana
authors.initials: M
authors.lastname: Stojanovic
authors.forename: Nilufar
authors.initials: N
authors.lastname: Mossaheb
authors.forename: Jochen
authors.initials: J
authors.lastname: Kindler
authors.forename: Sarah
authors.initials: S
authors.lastname: Cohen-Woods
authors.forename: Georgina
authors.initials: G
authors.lastname: Hosang
authors.forename: Anne
authors.initials: A
authors.lastname: Farmer
authors.forename: Ian
authors.initials: I
authors.lastname: Craig
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.forename: Harald
authors.initials: H
authors.lastname: Aschauer
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D002874:Chromosome Mapping / Q000379:methods; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics