title: Appetite control and glycaemia reduction in overweight subjects treated with a combination of two highly standardized extracts from Phaseolus vulgaris and Cynara scolymus.
abstract: The management of overweight may include the use of dietary supplements targeted to favour the increase of the satiation associated with a decrease in blood glucose and lipid levels. The aim of this study was to evaluate the efficacy of a dietary supplementation with an extract from Phaseolus vulgaris and Cynara scolymus, on satiation, the glucose and lipid pattern. A randomized, double-blind, placebo-controlled clinical trial was performed in 39 overweight subjects (20 supplemented group, 19 placebo group) for 2 months. The modification of satiation, by Haber's scale, was the primary end-point, and the variation of the glucose and lipid pattern, of the anthropometric parameters and of the psychodynamic tests score were the secondary end-points. At the end of treatment, the net change of the Haber's mean score increased significantly in the intervention group. The net change of the glycaemia and of the dietary restriction score of the three factor eating questionnaire (TFEQ), were reduced significantly only in the intervention group. Moreover, in the supplemented group, the homeostasis model assessment, the body mass index and the susceptibility-to-hunger score of the TFEQ, decreased significantly after intervention; these parameters did not change in the controls. This treatment appears potentially useful in the management of overweight and dysglycaemia.
authors.affiliation: Department of Health Sciences, Section of Human Nutrition, Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona, Pavia, University of Pavia, Pavia, Italy. mariangela.rondanelli@unipv.it.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rondanelli
authors.forename: Attilio
authors.initials: A
authors.lastname: Giacosa
authors.forename: Francesca
authors.initials: F
authors.lastname: Orsini
authors.forename: Annalisa
authors.initials: A
authors.lastname: Opizzi
authors.forename: Simona
authors.initials: S
authors.lastname: Villani
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects; D001069:Appetite Regulation / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis; D031943:Cynara scolymus / Q000737:chemistry*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000188:drug therapy*; D027805:Phaseolus / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D012527:Satiation / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts