title: [The cytokine profile in the acute period of tick-borne neuroinfections in children].
abstract: Clinical peculiarities and blood levels of several cytokines were studied in 199 children, aged from 1 to 15 years, in the acute period of different tick-borne infections. The mixed infection manifested itself by the more severe progression of general clinical presentations compared to monoinfections. Etiologically unspecific changes of blood concentrations of cytokines in the acute period of the disease were found. These data were associated with different clinical forms of tick-borne infections. The decrease in the interferon gamma production was associated with the most severe disease progression with focal nervous system disorders. The use of cycloferon as immune modulator in the complex therapy led to the increase in the interferon gamma level and the decrease of general clinical manifestations during tick-borne encephalitis and mixed infection.
authors.forename: T V
authors.initials: TV
authors.lastname: Poponnikova
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Bedareva
authors.forename: T N
authors.initials: TN
authors.lastname: Vakhrameeva
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Galieva
mesh_terms: D000166:Acridines / Q000627:therapeutic use; D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D004359:Drug Therapy, Combination; D004675:Encephalitis, Tick-Borne / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007223:Infant; D008193:Lyme Disease / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D008297:Male
chemical_list: D000166:Acridines; D016207:Cytokines; D007155:Immunologic Factors; C026430:10-carboxymethyl-9-acridanone