title: Total synthesis of brevenal.
abstract: This Article describes the total synthesis of the marine ladder toxin brevenal utilizing a convergent synthetic strategy. Critical to the success of this work was the use of olefinic-ester cyclization reactions and the utilization of glycal epoxides as precursors to C-C and C-H bonds.
authors.affiliation: Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: John
authors.initials: J
authors.lastname: Rohanna
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Karthik
authors.initials: K
authors.lastname: Iyer
authors.forename: Jon D
authors.initials: JD
authors.lastname: Rainier
mesh_terms: D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D004141:Dinoflagellida / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis*; D008387:Marine Toxins / Q000138:chemical synthesis; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D000475:Alkenes; D004852:Epoxy Compounds; D004987:Ethers; D008387:Marine Toxins; D011108:Polymers; C489035:brevenal (polyether)