title: Rebleeding risk after treatment of ruptured intracranial aneurysms.
abstract: OBJECTIVE
  Postprocedural rebleeding is a significant source of morbidity following endovascular treatment of ruptured intracranial aneurysms. Previous large-scale reports include the Cerebral Aneurysm Rerupture After Treatment trial, the International Subarachnoid Aneurysm Trial, and the study on Early Rebleeding after Coiling of Ruptured Cerebral Aneurysms, which reported nonprocedural rebleeding rates within 30 days of treatment of 2.7%, 1.9%, and 1.4%, respectively. However, coiling of intracranial aneurysms is in a state of continual change due to advancing device design and evolving techniques. These studies included only patients initially treated prior to 2004. In the present study the authors assess the most recent short-term results with endovascular treatment of ruptured aneurysms.
  
  
  METHODS
  A multicenter retrospective chart review was conducted of patients undergoing endovascular treatment for ruptured intracranial aneurysms between July 2004 and October 2009. The technique used, including the use of stent or balloon assistance, was evaluated. Demographic and clinical factors, such as sex, age, initial clinical presentation, aneurysm size, aneurysm location, and modified Raymond Classification following initial treatment, were also evaluated and compared between the groups in which rebleeding did and did not occur.
  
  
  RESULTS
  A total of 469 patients underwent endovascular treatment for a ruptured aneurysm; nonprocedural rehemorrhage occurred within 30 days of the initial coiling in 4 cases (0.9%). Two patients (50%) died after rehemorrhage. Stent-assisted coiling was used during the original treatment in 1 (25%) of the 4 patients with a rerupture. However, no technical, clinical, or demographic factors were found to be statistically significant in association with rebleeding.
  
  
  CONCLUSIONS
  Recent data suggest that the periprocedural rebleeding rate may be improving over time.
authors.affiliation: Department of Surgery, Division of Neurosurgery, University of Alabama, Birmingham, Alabama, USA.
authors.forename: J Brett
authors.initials: JB
authors.lastname: Fleming
authors.forename: Brian L
authors.initials: BL
authors.lastname: Hoh
authors.forename: Scott D
authors.initials: SD
authors.lastname: Simon
authors.forename: Babu G
authors.initials: BG
authors.lastname: Welch
authors.forename: Robert A
authors.initials: RA
authors.lastname: Mericle
authors.forename: Kyle M
authors.initials: KM
authors.lastname: Fargen
authors.forename: G Lee
authors.initials: GL
authors.lastname: Pride
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Purdy
authors.forename: Chevis N
authors.initials: CN
authors.lastname: Shannon
authors.forename: Mark R
authors.initials: MR
authors.lastname: Harrigan
mesh_terms: D000328:Adult; D000359:Aftercare; D000368:Aged; D017542:Aneurysm, Ruptured / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012306:Risk; D015607:Stents; D016896:Treatment Outcome