title: [The clinical research of serum soluble CD40L and high sensitivie C-reactive protein in patients with acute coronary syndrome].
abstract: OBJECTIVE
  To explore the clinical significance and mechanism of soluble CD40 Ligand (sCD40L) and high sensitive C-reactive protein (hs-CRP) in patients with acute coronary syndrome(ACS).
  
  
  METHODS
  A total of 86 consecutive patients with ACS were included in the study, according to the selection criteria for diagnosis of acute coronary syndrome (ACS), 86 patients were divided into two groups: normal and the ACS, In all patients, sCD40L and CRP levels were evaluated within 12 h. the incidence of acute cardiovascular events were observed after two months follow-up.
  
  
  RESULTS
  The ACS group was obviously higher than control group (P<0.01), AMI group slightly higher than the UA group but had no significant difference (P>0.05). sCD40L and hs-CRP group of cardiovascular events increased more than the normal group.
  
  
  CONCLUSIONS
  Acute coronary syndrome patients with early peripheral serum levels of sCD40L and hs-CRP were significantly increased, suggesting that CD40/CD40L system participate the occurrence of ACS, and the inflammatory factors such as C-reactive protein in collaboration, plays an important role on atherosclerotic plaque instability.
authors.affiliation: Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Fu
authors.forename: Ming
authors.initials: M
authors.lastname: Yuan
authors.forename: Li-Fen
authors.initials: LF
authors.lastname: Ren
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Guo
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D023201:CD40 Ligand / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D023201:CD40 Ligand; D002097:C-Reactive Protein