title: Changes in the incidence of candidaemia during 2000-2008 in a tertiary medical centre in northern Taiwan.
abstract: Candidaemia is associated with high mortality and high healthcare costs. The incidence of candidaemia in Taiwan rose markedly during the period 1980-2000. We conducted this hospital-based surveillance study in order to explore the secular trend in incidence of candidaemia during the period 2000 to 2008. In our study, Candida spp. were the fourth most common cause of bloodstream infections, with a 30-day crude mortality rate of 36.7%. Candida albicans was the most common species identified, although mortality rate did not differ significantly among species. The incidence of candidaemia began to decrease in 2004. Risk factors related to higher mortality included longer hospital stay before onset of candidaemia, liver cirrhosis, malignancy, end-stage renal disease requiring renal dialysis, dependence on mechanical ventilation and urinary catheterisation.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: L-Y
authors.initials: LY
authors.lastname: Chen
authors.forename: S-Y
authors.initials: SY
authors.lastname: Liao
authors.forename: S-C
authors.initials: SC
authors.lastname: Kuo
authors.forename: S-J
authors.initials: SJ
authors.lastname: Chen
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Chen
authors.forename: F-D
authors.initials: FD
authors.lastname: Wang
authors.forename: S-P
authors.initials: SP
authors.lastname: Yang
authors.forename: C-P
authors.initials: CP
authors.lastname: Fung
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000145:classification / Q000302:isolation & purification; D058387:Candidemia / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D003956:Dialysis; D005260:Female; D006761:Hospitals; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult