title: [Malignant degeneration in laryngeal papillomatosis].
abstract: Recurrent respiratory papillomatosis (RRP) is considered a benign disease although malignant transformation is well-described. The involvement of human papilloma virus (HPV) in malignant transformation is still being discussed. We present a case of rapid malignant transformation of RRP in a 29-year-old male. The tumour as well as biopsies from his previous laryngeal papillomas tested positive for HPV 16. Introduction of a quadrivalent HPV vaccine with a view to preventing cervical cancer may also reduce RRP, and subsequently possibly also the incidence of head-and-neck cancers.
authors.affiliation: Øre-næse-hals-afdelingen, Vejle Sygehus, 7100 Vejle, Denmark.
authors.forename: Ann-Luise Klinkby
authors.initials: AL
authors.lastname: Grøn
authors.forename: Joyce Horsmans
authors.initials: JH
authors.lastname: Schultz
authors.forename: Jørn
authors.initials: J
authors.lastname: Abildgaard
mesh_terms: D000328:Adult; D002472:Cell Transformation, Viral; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy / Q000821:virology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy / Q000821:virology; D010212:Papilloma / Q000473:pathology* / Q000628:therapy / Q000821:virology; D030361:Papillomavirus Infections / Q000175:diagnosis