title: Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010.
abstract: This report describes one case of verified treatment failure of pharyngeal gonorrhoea using ceftriaxone in Sweden. Previous reports described verified treatment failure of urogenital gonorrhoea using the internationally recommended first-line drug cefixime, but not with ceftriaxone, the last remaining option for empirical treatment of gonorrhoea. Enhanced awareness of clinical failures, pharmacodynamic considerations, follow-up and test of cure, adherence to appropriate case management and treatment guidelines as well as verification/falsification of presumed clinical treatment failures should be emphasised worldwide.
authors.affiliation: Swedish Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, orebro University Hospital, Orebro, Sweden. magnus.unemo@orebroll.se
authors.forename: M
authors.initials: M
authors.lastname: Unemo
authors.forename: D
authors.initials: D
authors.lastname: Golparian
authors.forename: A
authors.initials: A
authors.lastname: Hestner
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D006069:Gonorrhea / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D020010:Heterosexuality; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D010608:Pharyngeal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016133:Polymerase Chain Reaction; D017410:Practice Guidelines as Topic; D017422:Sequence Analysis, DNA; D013548:Sweden; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone