title: Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway.
abstract: Toll-like receptor (TLR) signaling is an important part of the innate immune response. One of the downstream responses to TLR4 signaling upon lipopolysaccharide (LPS) stimulation is the induction of autophagy, which is a key response to multiple stressors. An additional adaptive signaling molecule that is involved in the response to stress is heme oxygenase-1 (HO-1). HO-1 signaling is essential to limit inflammation and restore homeostasis. We found that LPS induced autophagic signaling in macrophages via a TLR4, HO-1 dependent pathway in macrophages. These data add to the developing contribution of autophagic signaling as part of the inflammatory response.
authors.affiliation: Department of Surgery, University of Pittsburgh, Pittsburgh, PA USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Waltz
authors.forename: Evie H
authors.initials: EH
authors.lastname: Carchman
authors.forename: Atalie C
authors.initials: AC
authors.lastname: Young
authors.forename: Jayashree
authors.initials: J
authors.lastname: Rao
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Rosengart
authors.forename: David
authors.initials: D
authors.lastname: Kaczorowski
authors.forename: Brian S
authors.initials: BS
authors.lastname: Zuckerbraun
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D016207:Cytokines / Q000096:biosynthesis; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D057809:HEK293 Cells; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; D051197:Toll-Like Receptor 4; D051547:Heme Oxygenase-1