title: Primary ovarian malignant lymphoma presenting as ovarian carcinomatosis: a case report and literature review.
abstract: BACKGROUND
  Primary ovarian lymphoma may present with a clinical scenario consistent with advanced epithelial ovarian carcinoma. Although ovarian lymphoma is a rare entity, accounting for 0.5% of all non-Hodgkin's lymphoma and 1.5% of all ovarian neoplasms, it should be included in the differential diagnosis of an ovarian mass.
  
  
  METHODS
  We report a case of a 78-year-old woman who presented with an ovarian neoplasm suggestive of advanced ovarian carcinoma. During diagnostic laparoscopy, biopsies were obtained with frozen section analysis revealing malignant lymphoma. Further histopathologic analysis revealed a diffuse large B-cell lymphoma (DLBCL). The treatment plan was for six cycles of R-CHOP chemotherapy. A drammatic response was noted after only three cycles of R-CHOP.
  
  
  CONCLUSIONS
  Primary ovarian lymphoma presenting as an ovarian tumor is exceedingly rare. Since the prognosis and treatment of lymphoma differs significantly from ovarian carcinoma, a representative tissue sample of the adnexal tumor should be obtained and sent for frozen section analysis to establish the diagnosis. Principal treatment for non-Hodgkin's lymphoma is chemotherapy without surgical cytoreductive efforts.
authors.affiliation: Department of Medical & Surgical Gynecology, Mayo Clinic, Phoenix, Arizona 85054, USA. kapetanakis.vasilis@mayo.edu
authors.forename: V
authors.initials: V
authors.lastname: Kapetanakis
authors.forename: N J
authors.initials: NJ
authors.lastname: Karlin
authors.forename: A E
authors.initials: AE
authors.lastname: McCullough
authors.forename: P M
authors.initials: PM
authors.lastname: Magtibay
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000473:pathology*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome