title: A novel methodology to evaluate health impacts caused by VOC exposures using real-time VOC and Holter monitors.
abstract: While various volatile organic compounds (VOCs) are known to show neurotoxic effects, the detailed mechanisms of the action of VOCs on the autonomic nervous system are not fully understood, partially because objective and quantitative measures to indicate neural abnormalities are still under development. Nevertheless, heart rate variability (HRV) has been recently proposed as an indicative measure of the autonomic effects. In this study, we used HRV as an indicative measure of the autonomic effects to relate their values to the personal concentrations of VOCs measured by a real-time VOC monitor. The measurements were conducted for 24 hours on seven healthy subjects under usual daily life conditions. The results showed HF powers were significantly decreased for six subjects when the changes of total volatile organic compound (TVOC) concentrations were large, indicating a suppression of parasympathetic nervous activity induced by the exposure to VOCs. The present study indicated these real-time monitoring was useful to characterize the trends of VOC exposures and their effects on autonomic nervous system.
authors.affiliation: Tokyo Metropolitan Industrial Technology Research Institute, Nishigaoka, 3-13-10, Kita-ku, Tokyo 115-8586, Japan. atsushi_mizukoshi@yy.k.u-tokyo.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizukoshi
authors.forename: Kazukiyo
authors.initials: K
authors.lastname: Kumagai
authors.forename: Naomichi
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Miyuki
authors.initials: M
authors.lastname: Noguchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshiuchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kumano
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yanagisawa
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000032:analysis*; D015716:Electrocardiography, Ambulatory / Q000379:methods; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D055549:Volatile Organic Compounds / Q000633:toxicity*; D055815:Young Adult
chemical_list: D055549:Volatile Organic Compounds