title: [Inflammatory myxohyaline tumor of the distal extremities].
abstract: Inflammatory myxohyaline tumor of the distal extremities is an extremely rare low-grade sarcoma with a tendency to produce local recurrence after surgical excision, but with a low metastatic potential. We present the case of a 49-year-old woman with a slow-growing asymptomatic tumor on the right pretibial region that was initially considered to be a lipoma. Histopathology revealed the presence of a polymorphic inflammatory infiltrate within a myxoid and hyaline matrix. Interspersed between the inflammatory cells were 3 different populations of neoplastic cells: atypical spindle-shaped cells; bizarre epithelioid cells, some of which were multinucleated and resembled the virocytes or Reed-Sternberg cells; and cells with abundant, vacuolated cytoplasm, similar to lipoblasts. These clinical-pathologic findings led to a diagnosis of inflammatory myxohyaline tumor of the distal extremities. Although the tumor was excised with wide surgical margins, local recurrence developed after 3 months and was treated with re-excision and radiotherapy.
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain. annaagusti@comv.es
authors.forename: A
authors.initials: A
authors.lastname: Agusti-Mejias
authors.forename: V
authors.initials: V
authors.lastname: Sabater
authors.forename: F
authors.initials: F
authors.lastname: Messeguer
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: R
authors.initials: R
authors.lastname: Ballester
authors.forename: S
authors.initials: S
authors.lastname: Marín
authors.forename: A
authors.initials: A
authors.lastname: Lloret
authors.forename: V
authors.initials: V
authors.lastname: Alegre
mesh_terms: D005260:Female; D005354:Fibrosarcoma / Q000473:pathology*; D006801:Humans; D007866:Leg; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D040521:Subcutaneous Tissue