title: Epidermal growth factor receptor positivity in angiomyolipoma contiguous to renal cell carcinoma: report of two cases with immunohistochemical analysis.
abstract: Renal cell carcinoma (RCC) and angiomyolipoma (AML), usually unassociated, have occasionally been reported to coexist in the same person, usually in patients with tuberous sclerosis. We report two patients without tuberous sclerosis whose nephrectomy specimens contained renal cell carcinoma directly contiguous to AML in the same kidney. When immunohistochemical staining for epidermal growth factor receptor (EGFR) was performed on the RCCs, an interesting observation was made. The contiguous AMLs demonstrated strong positivity for EGFR, a feature not observed in isolated AMLs. The significance of this finding is unclear. Paracrine regulation may exist between these two closely adjacent tumors leading to synchronous high expression of EGFR in the AML adjacent to RCC, which may in turn affect the biologic behavior of these AMLs, compared to AMLs not associated with RCC.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. kamin2@kumc.edu
authors.forename: Khalid
authors.initials: K
authors.lastname: Amin
authors.forename: Maura F
authors.initials: MF
authors.lastname: O'Neil
authors.forename: Fang
authors.initials: F
authors.lastname: Fan
authors.forename: Douglas H
authors.initials: DH
authors.lastname: McGregor
mesh_terms: D000368:Aged; D018207:Angiomyolipoma / Q000150:complications* / Q000201:enzymology* / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000201:enzymology* / Q000473:pathology; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000150:complications* / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors