title: Correlation between serum 25-hydroxyvitamin D levels and quadriceps muscle strength in elderly cretans.
abstract: Vitamin D deficiency is associated with osteomalacic myopathy, and muscle weakness related to vitamin D deficiency has been implicated as a possible risk factor for falls in the elderly. This study investigated the possible correlation between serum 25-hydroxyvitamin D (25[OH]D) concentration and quadriceps muscle strength in ambulatory community dwelling Cretan men (n=13) and women (n=35) aged > or = 65 years. Quadriceps muscle strength was measured isometrically using Cybex 6000 apparatus. The mean serum 25(OH)D concentration was significantly higher in men than in women (76.00 versus 49.11 nmol/l, respectively). Serum 25(OH)D values were < 50 nmol/l in 15% of men and in 60% of women. Serum 25(OH)D concentration correlated positively with quadriceps muscle strength. In conclusion, vitamin D deficiency was common in the study participants despite the high levels of sunlight in Crete. Serum 25(OH)D levels were positively correlated with muscle strength.
authors.affiliation: Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece. olga.dretakis@gmail.com
authors.forename: O E
authors.initials: OE
authors.lastname: Dretakis
authors.forename: C
authors.initials: C
authors.lastname: Tsatsanis
authors.forename: A
authors.initials: A
authors.lastname: Fyrgadis
authors.forename: C G
authors.initials: CG
authors.lastname: Drakopoulos
authors.forename: K
authors.initials: K
authors.lastname: Steriopoulos
authors.forename: A N
authors.initials: AN
authors.lastname: Margioris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D052097:Quadriceps Muscle / Q000503:physiopathology*; D013472:Sunlight; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D