title: Extraperitoneal renal transplantation in small children results in a transient improvement in early graft function.
abstract: Renal transplantation is considered more technically challenging in small children compared to adults, especially when live donor adult kidneys are used. Transplanted kidneys have traditionally been placed intraperitoneally, although over the last decade extraperitoneal positioning has been attempted. The aim of this study was to establish whether there is a difference in kidney function and outcome dependent on the surgical approach to transplantation. The medical notes of all children under the age of six who received a renal transplant at our unit between January 1998 and October 2009 were reviewed. Demographic data, operation details, HLA mismatch, immunosuppression regime, complications, and function of the graft were analyzed. A total of 30 transplants were performed in children under six yr of age. The one-yr patient and graft survival were 97% and 93%, respectively. Eighteen were undertaken via an intraperitoneal approach, with the remaining being placed extraperitoneally. There were no significant differences in the number of complications observed between the two groups, and median length of stay was comparable (extraperitoneal 19.5 days vs. intraperitoneal 20.5 days). The plasma creatinine values for the two groups were compared using multivariate linear regression analysis and adjusted for age, weight, gender and baseline plasma creatinine. Between days 2 and 14 post-operatively, there was a significant difference in absolute plasma creatinine between the two surgical approaches. However, the trend of change in mean plasma creatinine values over time did not differ significantly between the two groups. Extraperitoneal kidney transplantation in small children is safe and technically feasible. From our series, there appears to be early improved function, although there is no long-term difference in function between approaches.
authors.affiliation: The Transplant Unit, Manchester Royal Infirmary, Manchester, UK. sarahheap@hotmail.co.uk
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Heap
authors.forename: Nicholas J A
authors.initials: NJ
authors.lastname: Webb
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Kirkman
authors.forename: Denise
authors.initials: D
authors.lastname: Roberts
authors.forename: Hany
authors.initials: H
authors.lastname: Riad
mesh_terms: D000886:Anthropometry; D001835:Body Weight; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016001:Confidence Intervals; D003404:Creatinine / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D016014:Linear Models; D019520:Living Donors; D008297:Male; D010529:Peritoneal Cavity / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D012187:Retroperitoneal Space / Q000601:surgery*; D012189:Retrospective Studies; D018570:Risk Assessment; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003404:Creatinine