title: Analysis of factors associated with prognosis after colorectal cancer resection in 174 Chinese elderly patients.
abstract: OBJECTIVE
  The purpose of the present study was to investigate risk factors associated with prognosis in elderly patients with colorectal cancer (CRC) and to determine treatment and follow-up strategies.
  
  
  METHODS
  CRC patients (age ≥70) who were treated with curative operation were studied. We compared 57 patients whose survival time was less than 2 years with 117 patients with survival time exceeding 5 years, based on the clinical, pathologic, and preoperative clinical laboratory analysis findings. A risk scoring system on basis of factors determined by multiple logistic regression analysis was explored and validated by both receiver operating characteristic and survival analysis.
  
  
  RESULTS
  Neuroticism, rural residence, deep layer invasion, lymphovascular invasion, and high serum CEA levels were found to be associated with adverse prognosis in the multivariate logistic regression model. Risk scoring system based on these factors showed that the patients with total score exceeding 2.5 had a significantly poorer prognosis (P < 0.05), which was validated by survival analysis.
  
  
  CONCLUSIONS
  Patients with neuroticism, rural residence, deep layer invasion, lymphovascular invasion, and high serum CEA level should be regarded as a high-risk group; a simple scoring system based on these factors could be used to evaluate the risk and facilitate treatment of CRC for elderly patients.
authors.affiliation: Department of Abdominal Surgery, The Affiliated Tumor Hospital, Harbin Medical University, Harbin 150086, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiang
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Li
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Qiu
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.forename: Xishan
authors.initials: X
authors.lastname: Wang
authors.forename: Sanjun
authors.initials: S
authors.lastname: Cai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000523:psychology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D010551:Personality; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors; D012424:Rural Population