title: PARP inhibitors in cancer therapy: promise, progress, and puzzles.
abstract: A recent article in the New England Journal of Medicine by O'Shaughnessy et al. provides evidence that a treatment strategy aimed at inducing DNA damage with chemotherapy while simultaneously disabling repair using a PARP inhibitor might offer hope for patients with a treatment-refractory form of breast cancer.
authors.affiliation: Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, 02114, USA. ellisen@helix.mgh.harvard.edu
authors.forename: Leif W
authors.initials: LW
authors.lastname: Ellisen