title: Osteoarthritis and degenerative joint disease: local treatment options update.
abstract: This review describes intra-articular drugs therapy of arthritis and degenerative joint disease) with a range of old and recent molecules with specific focus on hyaluronic acid. HA is a cartilage matrix basic component secreted by chondrocytes: it prevents cartilage degradation by a complex interpherence between metalloproteinases, pain mediators and cells. Local injections of HA improve functional activity and pain management, particularly when it is combined with other selected drugs.
authors.affiliation: Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Italy. palmieri@unimo.it
authors.forename: Beniamino
authors.initials: B
authors.lastname: Palmieri
authors.forename: Daniele
authors.initials: D
authors.lastname: Lodi
authors.forename: Stefania
authors.initials: S
authors.lastname: Capone
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D010003:Osteoarthritis / Q000188:drug therapy*; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D055675:Viscosupplements; D006820:Hyaluronic Acid