title: Lessons on transcriptional control from the serum response network.
abstract: Response to environmental stimuli is critical for cell survival and function and requires high fidelity signal transduction into the nucleus to facilitate the coordinated transcriptional regulation of appropriate gene networks. The cellular response to mitogenic stimuli provides an excellent paradigm to decipher the mechanisms mediating precise gene expression control at the transcriptional level. Here we review recent advances in our understanding of this so-called serum response network, which illuminate novel aspects of nuclear signaling mechanisms, combinatorial control by DNA binding proteins and regulation of RNA polymerase II (RNAPII) elongation.
authors.affiliation: Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, CO, United States.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Galbraith
authors.forename: Joaquín M
authors.initials: JM
authors.lastname: Espinosa
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism; D027602:Serum Response Element; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D012319:RNA Polymerase II