title: Synthesis, characterization and anti-tumor activity of moxifloxacin-copper complexes against breast cancer cell lines.
abstract: Novel moxifloxacin-copper complexes were synthesized, characterized and screened for anti-proliferative and apoptosis-inducing activity against multiple human breast cancer cell lines (hormone-dependent MCF-7 and T47D as well as hormone-independent MDA-MB-231 and BT-20). The results indicated that the parent compound moxifloxacin (1) does not exert any inhibitory activity against breast cancer cell lines examined. On the other hand, the copper conjugate 2 and its nitrogen adducts 3-5 exerted growth inhibitory and apoptosis-inducing activity against breast cancer cell lines without any substantial effect on non-tumorigenic breast epithelial cells MCF-10A at equimolar concentration, suggesting a cancer cell-specific activity. BT-20 cells were more sensitive to compounds 2 and 3, while compounds 4 and 5 exerted significant anti-proliferative and apoptosis-inducing effects on T47D, MDA-MB-231 and BT-20 cell lines. Our results suggest that these novel compounds could be useful for the treatment of breast cancer in the future.
authors.affiliation: Department of Chemistry, University of Pune, Pune, India.
authors.forename: Sommai
authors.initials: S
authors.lastname: Patitungkho
authors.forename: Shreelekha
authors.initials: S
authors.lastname: Adsule
authors.forename: Prasad
authors.initials: P
authors.lastname: Dandawate
authors.forename: Subhash
authors.initials: S
authors.lastname: Padhye
authors.forename: Aamir
authors.initials: A
authors.lastname: Ahmad
authors.forename: Fazlul H
authors.initials: FH
authors.lastname: Sarkar
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D000077266:Moxifloxacin; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D003300:Copper; D000077266:Moxifloxacin