title: Room temperature, metal-free synthesis of diaryl ethers with use of diaryliodonium salts.
abstract: A fast, high-yielding synthesis of diaryl ethers with use of mild and metal-free conditions has been developed. The scope includes bulky ortho-substituted diaryl ethers, which are difficult to obtain by metal-catalyzed protocols. Halo-substituents, racemization-prone amino acid derivatives, and heteroaromatics are also tolerated. The methodology is expected to be of high utility in the synthesis of complex molecules and in the pharmaceutical industry.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Nazli
authors.initials: N
authors.lastname: Jalalian
authors.forename: Eloisa E
authors.initials: EE
authors.lastname: Ishikawa
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Silva
authors.forename: Berit
authors.initials: B
authors.lastname: Olofsson
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D010647:Phenyl Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D012492:Salts; D013696:Temperature
chemical_list: D000596:Amino Acids; D006847:Hydrocarbons, Iodinated; D010636:Phenols; D010647:Phenyl Ethers; D012492:Salts