title: Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary gland.
abstract: Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare tumor, defined in the 2005 WHO classification as a primary salivary duct tumor. Previously, the neoplasm had been recognized as a variant of salivary duct carcinomas. A 56-year-old Japanese woman noticed a mass in the left subaural region. On radiological examinations, a multicystic tumor was seen in the left parotid gland. Fine-needle aspiration biopsy was performed. The smears revealed several characteristic cytologic features. The tumor cells were arranged in irregular overlapping and showed inconspicuous nuclear atypia with variable-sized and irregularly shaped cytoplasmic vacuoles. Based on these findings, a cystic tumor with uncertain malignancy was diagnosed. A parotidectomy was performed, because the tumor was slowly growing and contained solid components on the radiological images. Based on the histologic findings, along with immunohistochemistry, LGCCC was diagnosed based on resemblance to breast low-grade ductal carcinoma in situ and intraductal proliferation of tumor cells. This is the first report of the cytomorphological findings of LGCCC.
authors.affiliation: Department of Pathology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, 1110 Shimokato, Yamanashi, Japan. tadaon@yamanashi.ac.jp
authors.forename: Tadao
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kondo
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yuminomochi
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ishii
authors.forename: Kunio
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Tetsu
authors.initials: T
authors.lastname: Yamane
authors.forename: Masanori
authors.initials: M
authors.lastname: Miyata
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.forename: Ryohei
authors.initials: R
authors.lastname: Katoh
mesh_terms: D044963:Biopsy, Fine-Needle; D003536:Cystadenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology*; D012796:Sialography; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed