title: New players in ovarian cancer.
abstract: Ovarian cancer is the leading cause of gynecologic cancer mortality worldwide. The aim of this review is to highlight the most recent studies regarding ovarian cancer pathogenesis and the new therapeutic approaches against this insidious disease. We focus on the relevance of some cell cycle genes, transcription factors, and microRNAs in the carcinogenesis of ovarian cancer as well as on a new hypothesis for therapy using histone deacetylase inhibitors. We also report recent studies regarding some mechanisms of chemoresistance, a major obstacle in the treatment of ovarian cancer. Together these studies can improve our knowledge of ovarian cancer tumorigenesis and diagnosis providing new tools to hopefully defeat this deadly disease.
authors.affiliation: Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bovicelli
authors.forename: Giuseppina
authors.initials: G
authors.lastname: D'Andrilli
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002453:Cell Cycle / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D005260:Female; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D035683:MicroRNAs; D014157:Transcription Factors