title: Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan.
abstract: OBJECTIVE
  To elucidate the clinicopathological findings of primary intestinal enteropathy-associated T cell lymphoma (EATL) in Japan, a non-endemic area for coeliac disease.
  
  
  RESULTS
  Of the 24 cases, four (17%) had large-cell lymphoma (type I), and the remaining 20 (83%) had medium-sized lymphoma (type II). Lymphoma cells of the three type I cases were CD56-positive. Only one (4%) case showed typical CD56- and CD8-negative and CD30-positive type I EATL. In type II EATL, lymphoma cells of the 16 (80%) and 11 (55%) cases were positive for CD56 and CD8, respectively. Intramucosal tumour spreading and adjacent enteropathy-like lesions were detected in 15 (71%) and 16 (76%) of 21 cases, with a severe increase of intraepithelial lymphocytes (IELs) in 12 (57%). IELs of enteropathy-like lesions in five (24%) cases expressed T-bet, with no cases of CD30-positive IELs. Characteristic findings from comparative genomic hybridization of 15 cases indicated gains of 8q2 (47%), Xp (53%) and Xq (73%), but no gain of 9q3. Regarding, human leucocyte antigen (HLA) status, six cases examined did not express the DQB1*02 allele.
  
  
  CONCLUSIONS
  Japanese EATL exhibited different histology, cytogenetic findings and HLA status from those of typical type I EATL. The rare incidence of coeliac disease may influence the tumour cell characteristics of EATL and IELs.
authors.affiliation: Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. m-take@adm.fukuoka-u.ac.jp
authors.forename: Morishige
authors.initials: M
authors.lastname: Takeshita
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kanta
authors.initials: K
authors.lastname: Kikuma
authors.forename: Yoshifuku
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Shogo
authors.initials: S
authors.lastname: Urabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ogawara
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Yonemasu
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Kennosuke
authors.initials: K
authors.lastname: Karube
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwashita
mesh_terms: D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007422:Intestines / Q000473:pathology; D007564:Japan; D008297:Male; D008875:Middle Aged