title: Serum selenium levels in hemodialysis patients are significantly lower than those in healthy controls.
abstract: Serum selenium levels have been thought to be decreased in hemodialysis patients; however, results of previous studies have been inconsistent. Population-based hemodialysis patients (n = 1,041) and randomly recruited healthy controls (n = 384) were enrolled. Serum selenium levels were determined by inductively coupled plasma mass spectrometry and compared in hemodialysis patients and controls using analysis of covariance after adjustment for confounding factors with p < 0.1 as the result of the multiple regression analysis. Age, serum albumin levels, hsCRP levels, LDLC levels, HDLC levels, regular drinking habit and hemodialysis treatment were significantly associated with serum selenium levels in multiple regression analysis. Multivariate-adjusted means (95% CIs) of serum selenium levels were 103 μg/l (101-105) in hemodialysis patients and 117 μg/l (114-121) in controls. Selenium levels in hemodialysis patients were decreased. Whether decreased serum selenium levels contribute to increased risks for morbidity and mortality in hemodialysis patients should be examined.
authors.affiliation: Department of Hygiene and Preventive Medicine, Iwate Medical University, Morioka, Japan. fyosuke@iwate-med.ac.jp
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Fujishima
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Itai
authors.forename: Karen
authors.initials: K
authors.lastname: Kato
authors.forename: Kozo
authors.initials: K
authors.lastname: Tanno
authors.forename: Tanvir Chowdhury
authors.initials: TC
authors.lastname: Turin
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Onoda
authors.forename: Shigeatsu
authors.initials: S
authors.lastname: Endo
authors.forename: Akira
authors.initials: A
authors.lastname: Okayama
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujioka
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D012643:Selenium / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D012709:Serum Albumin; D002097:C-Reactive Protein; D012643:Selenium