title: Apparent life threatening event and gastric antral ulcer in a full-term infant: any possible relationship?
abstract: We describe the case of an apparently healthy newborn infant who in 7th day of life showed an episode of haematemesis and in 13th day of life presented an episode of apparent life threatening event (ALTE). A fibroscopy of the upper digestive tract showed a great ulcer of the gastric antrum and esophagitis limited to the mucosa. Gastrinemia in the blood showed high values (121 pg/ml). The relationship between ALTE and gastric ulcer may be casual, however in literature a gastroenteric cause is present in about 50% of ALTE in which an etiologic cause is found. We speculate that in the present case the increase of gastrin secretion reduced gastric pH which facilitated the onset of gastric ulcer and esophagitis with ALTE due to pain or reflex.
authors.affiliation: Department of Gynecology, Obstetrics and Neonatological Sciences, University Hospital, Parma, Italy. plbacchini@ao.pr.it
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Bacchini
authors.forename: Enzo
authors.initials: E
authors.lastname: Romanini
authors.forename: Cinzia
authors.initials: C
authors.lastname: Magnani
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: De'Angelis
authors.forename: Giulio
authors.initials: G
authors.lastname: Bevilacqua
mesh_terms: D001706:Biopsy; D016638:Critical Illness; D005755:Gastrins / Q000097:blood; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000473:pathology* / Q000628:therapy; D008297:Male; D011706:Pyloric Antrum / Q000473:pathology*; D013276:Stomach Ulcer / Q000097:blood / Q000473:pathology* / Q000628:therapy
chemical_list: D005755:Gastrins