title: [Phosphodiesterase 4 inhibitors: a new pharmacologic group in the treatment of chronic inflammation of the airways].
authors.affiliation: Unidad de Docencia e Investigación. Consorcio Hospital General Universitario de Valencia; Departamento de Farmacología. Facultad de Medicina y Odontología. Universitat de Valencia. Valencia. España.
authors.forename: Julio
authors.initials: J
authors.lastname: Cortijo Gimeno
mesh_terms: D000631:Aminopyridines / Q000493:pharmacokinetics / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000493:pharmacokinetics / Q000627:therapeutic use; D002923:Cilia / Q000187:drug effects / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D003521:Cyclopropanes / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation; D007527:Isoenzymes / Q000502:physiology; D009077:Mucins / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D058988:Phosphodiesterase 4 Inhibitors / Q000627:therapeutic use*; D010727:Phosphoric Diester Hydrolases / Q000502:physiology; D011652:Pulmonary Circulation / Q000187:drug effects; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000201:enzymology; D011656:Pulmonary Emphysema / Q000188:drug therapy* / Q000201:enzymology; D015290:Second Messenger Systems
chemical_list: D000631:Aminopyridines; D000893:Anti-Inflammatory Agents; D001549:Benzamides; D003521:Cyclopropanes; D007527:Isoenzymes; D009077:Mucins; D058988:Phosphodiesterase 4 Inhibitors; C424423:Roflumilast; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP