title: [Clinical features of the formation and possibilities of treatment of posttraumatic cognitive disturbances].
abstract: We studied the efficacy of akatinol memantine compared to that of piracetam in the treatment of 41 patients with posttraumatic cognitive disturbances (20 patients were treated with akatinol memannine and 21 patients with piracetam) during 24 weeks. Ten patients had a severe traumatic brain injury (TBI) and 11 patients had mild TBI. Treatment efficacy was assessed during 6 months using the data of clinical examination, neuropsychological testing, CT and MRI. Akatinol exerted a distinct positive, stable and continuously effect on a broad spectrum of cognitive disturbances while the effect of piracetam was observed only for some cognitive functions and was short-term (during 1 month). Both drugs were well-tolerated by patients.
authors.forename: I V
authors.initials: IV
authors.lastname: Litvinenko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Emelin
authors.forename: S V
authors.initials: SV
authors.lastname: Vorob'ev
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Lobzin
mesh_terms: D001930:Brain Injuries / Q000150:complications*; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008559:Memantine / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000627:therapeutic use; D010889:Piracetam / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018697:Nootropic Agents; D008559:Memantine; D010889:Piracetam