title: Oxytocin, but not arginine vasopressin is involving in the antinociceptive role of hypothalamic supraoptic nucleus.
abstract: Our previous study has demonstrated that the hypothalamic supraoptic nucleus (SON) plays a role in pain modulation. Oxytocin (OXT) and arginine vasopressin (AVP) are the important hormones synthesized and secreted by the SON. The experiment was designed to investigate which hormone was relating with the antinociceptive role of the SON in the rat. The results showed that (1) microinjection of L-glutamate sodium into the SON increased OXT and AVP concentrations in the SON perfusion liquid, (2) pain stimulation induces OXT, but not AVP release in the SON, and (3) intraventricular injection (pre-treatment) with OXT antiserum could inhibit the pain threshold increase induced by SON injection of L-glutamate sodium, but administration of AVP antiserum did not influence the antinociceptive role of SON stimulation. The data suggested that the antinociceptive role of the SON relates to OXT rather than AVP.
authors.affiliation: School of Pharmacy, Xinxiang Medical University, Xixiang, Henan 453003, China. bcd2009@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jin-Ying
authors.initials: JY
authors.lastname: Liang
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Zhang
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Qiu
authors.forename: Yan-Juan
authors.initials: YJ
authors.lastname: Pan
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Hao
authors.forename: Da-Xin
authors.initials: DX
authors.lastname: Wang
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Yan
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D018698:Glutamic Acid / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010121:Oxytocin / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013495:Supraoptic Nucleus / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D000700:Analgesics; D001127:Arginine Vasopressin; D018698:Glutamic Acid; D010121:Oxytocin