title: [Dependence of biological activity of N-acyl derivates of 6-alkoxy-2-methyl-4-mercaptoquinoline on the nature of substituents in the position 6 of the heterocycle].
abstract: The influence of substituents in the sixth position of N-acyl derivatives of 2-methyl-4-mercaptoquinoline on hepatoprotective and antioxidant effect was investigated. It was also determined that alcoxy-derivatives show hepatoprotective, antiradical, antioxidant activity and can act as preventive antioxidants. Introduction of the ethoxy-group into the sixth position of azoheterocycle potentiates activity. Symbasis of intensities of hepatoprotective and antioxidant actions of the investigated compounds was proved.
authors.forename: I B
authors.initials: IB
authors.lastname: Labens'ka
authors.forename: H S
authors.initials: HS
authors.lastname: Shapoval
authors.forename: O S
authors.initials: OS
authors.lastname: Kruhliak
authors.forename: L O
authors.initials: LO
authors.lastname: Omel'ianchyk
authors.forename: O A
authors.initials: OA
authors.lastname: Brazhko
authors.forename: M P
authors.initials: MP
authors.lastname: Zavhorodniĭ
mesh_terms: D000215:Acylation; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control; D002784:Cholesterol / Q000378:metabolism; D004195:Disease Models, Animal; D004563:Electrochemistry; D004566:Electrodes; D005947:Glucose / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011804:Quinolines; D014280:Triglycerides; D002784:Cholesterol; D005947:Glucose