title: Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
abstract: A series of quinoline derivatives was synthesized as potential bioisosteric replacements for the benzothiadiazine moiety of earlier Hepatitis C NS5B polymerase inhibitors. Several of these compounds exhibited potent activity in enzymatic and replicon assays.
authors.affiliation: Department of Antiviral Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. hutsmi@sbcglobal.net
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Hutchinson
authors.forename: Charles A
authors.initials: CA
authors.lastname: Flentge
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Donner
authors.forename: Rolf
authors.initials: R
authors.lastname: Wagner
authors.forename: Clarence J
authors.initials: CJ
authors.lastname: Maring
authors.forename: Warren M
authors.initials: WM
authors.lastname: Kati
authors.forename: Yaya
authors.initials: Y
authors.lastname: Liu
authors.forename: Sherie V
authors.initials: SV
authors.lastname: Masse
authors.forename: Tim
authors.initials: T
authors.lastname: Middleton
authors.forename: Hongmei
authors.initials: H
authors.lastname: Mo
authors.forename: Debra
authors.initials: D
authors.lastname: Montgomery
authors.forename: Wen W
authors.initials: WW
authors.lastname: Jiang
authors.forename: Gennadiy
authors.initials: G
authors.lastname: Koev
authors.forename: David W A
authors.initials: DW
authors.lastname: Beno
authors.forename: Kent D
authors.initials: KD
authors.lastname: Stewart
authors.forename: Vincent S
authors.initials: VS
authors.lastname: Stoll
authors.forename: Akhteruzzaman
authors.initials: A
authors.lastname: Molla
authors.forename: Dale J
authors.initials: DJ
authors.lastname: Kempf
mesh_terms: D001581:Benzothiadiazines / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000201:enzymology / Q000502:physiology; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D014779:Virus Replication; D012324:RNA-Dependent RNA Polymerase
chemical_list: D001581:Benzothiadiazines; D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase