title: Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein.
abstract: In a previous study, we demonstrated that transgenic mice that express Borna disease virus (BDV) phosphoprotein (P) in astrocytes show striking neurobehavioral abnormalities resembling those in BDV-infected animals. To understand the molecular disturbances induced by the expression of P in astrocytes, we performed microarray analysis with cultured astroglial cells transiently expressing P. We showed that expression of insulin-like growth factor binding protein 3 mRNA increases not only in P-expressing cultured cells but also in astrocytes from the cerebella of P transgenic mice (P-Tg). Furthermore, we demonstrated that insulin-like growth factor signaling is disturbed in the P-Tg cerebellum, a factor that might be involved in the increased vulnerability of Purkinje cell neurons in the brain.
authors.affiliation: Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Honda
authors.forename: Kan
authors.initials: K
authors.lastname: Fujino
authors.forename: Daisuke
authors.initials: D
authors.lastname: Okuzaki
authors.forename: Naohiro
authors.initials: N
authors.lastname: Ohtaki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Horie
authors.forename: Takuji
authors.initials: T
authors.lastname: Daito
authors.forename: Masayuki
authors.initials: M
authors.lastname: Itoh
authors.forename: Keizo
authors.initials: K
authors.lastname: Tomonaga
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000821:virology*; D001891:Borna disease virus / Q000472:pathogenicity*; D002478:Cells, Cultured; D020869:Gene Expression Profiling; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000096:biosynthesis*; D051379:Mice; D008822:Mice, Transgenic; D046228:Microarray Analysis; D010750:Phosphoproteins / Q000378:metabolism*; D015854:Up-Regulation; D015678:Viral Structural Proteins / Q000378:metabolism*
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; C496537:P protein, Borna disease virus; D010750:Phosphoproteins; D015678:Viral Structural Proteins