title: Fine mapping of a psoriasis-susceptibility locus within the HLA class II region by using microsatellite markers in an association study of Japanese cases and controls.
abstract: BACKGROUND
  The association between psoriasis and the HLA antigens encoded by the Major Histocompatibility Complex (MHC) genomic region is well known, but the role of the HLA class II region in susceptibility to psoriasis is unclear.
  
  
  OBJECTIVE
  The purpose of this study is to map the psoriasis-susceptibility locus within the HLA class II region.
  
  
  METHODS
  Three hundred seventy five unrelated Japanese patients with psoriasis vulgaris and 375 unrelated Japanese healthy controls were studied by an association analysis using 15 polymorphic microsatellite markers.
  
  
  RESULTS
  Statistically significant differences were found at three microsatellite loci. The most significant association of psoriasis vulgaris with the microsatellite markers was found with DRA_CA (pc=0.0000135), the second with DQCARII (pc=0.0000840) and the third with G5_11525 (pc=0.0240). These significant microsatellite markers are in close vicinity to the DQA2, DQB1, DRB1, DRA and BTNL2 genes.
  
  
  CONCLUSIONS
  The results suggest that there are psoriasis susceptibility genes located within the HLA class II region and therefore strongly support previous findings of a positive association between psoriasis and certain alleles of the DQB1 and DRB1 genes.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. mabuchi@is.icc.u-tokai.ac.jp
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.forename: Mariko
authors.initials: M
authors.lastname: Iizuka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Umezawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kubota
authors.forename: Juichiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Tadashi
authors.initials: T
authors.lastname: Terui
authors.forename: Maki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yasumoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Sueki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Iijima
authors.forename: Jerzy K
authors.initials: JK
authors.lastname: Kulski
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology*
chemical_list: D000949:Histocompatibility Antigens Class II