title: [Effects of kappa-opioid receptor stimulation on high glucose induced myocardial hypertrophy of neonatal rats].
abstract: OBJECTIVE
  To observe the effects of kappa-opioid receptor stimulation on high glucose induced myocardial hypertrophy of neonatal rats.
  
  
  METHODS
  Using cultured myocardial cells as a model, the protein content was assayed with Lowrys method. The cardiomyocytes volumes were measured by computer photograph analysis system. The level of p-ERK44/42 was determined by Western blot.
  
  
  RESULTS
  Compared with the control, U50488H significantly inhibited the protein content and volumes of cultured hypertrophic myocardial cells induced by high glucose. Meanwhile the role of ERK was important.
  
  
  CONCLUSIONS
  The stimulation of kappa-opioid can inhibit myocardial hypertrophy induced by high glucose, which is possibly via attenuating p-ERK.
authors.affiliation: Department of Pharmacology, Jinzhou Medical College, Jinzhou 121001, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Liu
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Mei-Li
authors.initials: ML
authors.lastname: Lu
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Wu
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D006332:Cardiomegaly / Q000378:metabolism*; D002478:Cells, Cultured; D005260:Female; D005947:Glucose / Q000009:adverse effects*; D020935:MAP Kinase Signaling System; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017473:Receptors, Opioid, kappa / Q000378:metabolism*
chemical_list: D017473:Receptors, Opioid, kappa; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D005947:Glucose