title: Biogenesis of extracellular vesicles in yeast: Many questions with few answers.
abstract: The cellular events required for unconventional protein secretion in eukaryotic pathogens are beginning to be revealed. In fungi, extracellular release of proteins involves passage through the cell wall by mechanisms that are poorly understood. In recent years, several studies demonstrated that yeast cells produce vesicles that traverse the cell wall to release a wide range of cellular components into the extracellular space. These studies suggested that extracellular vesicle release involves components of both conventional and unconventional secretory pathways, although the precise mechanisms required for this process are still unknown. We discuss here cellular events that are candidates for regulating this interesting but elusive event in the biology of yeast cells.
authors.affiliation: Laboratório de Estudos Integrados em Bioquímica Microbiana; Instituto de Microbiologia Professor Paulo de Góes; Rio de Janeiro; Brazil.
authors.forename: Débora L
authors.initials: DL
authors.lastname: Oliveira
authors.forename: Ernesto S
authors.initials: ES
authors.lastname: Nakayasu
authors.forename: Luna S
authors.initials: LS
authors.lastname: Joffe
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Guimarães
authors.forename: Tiago Jp
authors.initials: TJ
authors.lastname: Sobreira
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Nosanchuk
authors.forename: Radames Jb
authors.initials: RJ
authors.lastname: Cordero
authors.forename: Susana
authors.initials: S
authors.lastname: Frases
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Igor C
authors.initials: IC
authors.lastname: Almeida
authors.forename: Leonardo
authors.initials: L
authors.lastname: Nimrichter
authors.forename: Marcio L
authors.initials: ML
authors.lastname: Rodrigues