title: Relationship between biochemical markers and radial cortical bone changes in hemodialysis patients.
abstract: OBJECTIVE
  Bone loss in patients with osteoporosis may be predicted by the elevation of biochemical markers of bone turnover. Therefore, we studied the relationship between biochemical markers, including parathyroid hormone (PTH), and the 2-year change in radial cortical bone in patients under chronic hemodialysis.
  
  
  METHODS
  Tartrate-resistant acid phosphatase-5b (TRACP-5b), bone-specific alkaline phosphatase, whole PTH, and total intact PTH were measured in 53 patients under maintenance hemodialysis. Additionally, radial cortical bone mineral density (BMD) and relative cortical area (RCA) were measured by peripheral quantitative computed tomography 2 years apart.
  
  
  RESULTS
  In all patients, BMD decreased by 2.5% and RCA decreased by 5.8% during 2 years. TRACP-5b levels significantly correlated with decreased RCA in all and female patients, but not with decreased BMD. Bone-specific alkaline phosphatase correlated with decreased BMD in all patients and with decreased RCA in all and female patients. Whole PTH did not correlate with decreased RCA or BMD. Total intact PTH significantly correlated with decreased BMD in all and male patients and with decreased RCA in all and female patients. In stepwise multiple regression analysis, TRACP-5b and total intact PTH were selected as explanatory variables for decreased RCA and decreased BMD, respectively.
  
  
  CONCLUSIONS
  These results suggest that TRACP-5b and total intact PTH are powerful markers to predict radial cortical bone loss in hemodialysis patients.
authors.affiliation: Division of Blood Purification and Kidney Center, Konan Hospital, 1-5-16 Kamokogahara, Higashinada-ku, Kobe, Japan. louie@kcc.zaq.ne.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Fujimori
authors.forename: Shioko
authors.initials: S
authors.lastname: Okada
authors.forename: Makoto
authors.initials: M
authors.lastname: Sakai
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tome
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011884:Radius / Q000378:metabolism* / Q000502:physiology; D006435:Renal Dialysis / Q000009:adverse effects; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D010281:Parathyroid Hormone; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase