title: [Expression of endostatin and its relationship with the clinical pathophysiological characteristics in non-small cell lung cancer].
abstract: BACKGROUND
  To study the relationship between expression of endostatin and clinical and pathophysiological characteristics in the non-small cell lung cancer (NSCLC).
  
  
  METHODS
  The expression of endostatin was detected in 46 lung cancer tissues and paracancerous lung tissues, 14 benign pulmonary lesion tissues as control by immunohistochemical staining (LSAB method).
  
  
  RESULTS
  The expression of endostatin in lung cancer tissues (84.91%±7.65%) was significantly higher than that in paracancerous tissues (63.70%±12.45%) and benign pulmonary lesion tissues (40.29%±15.01%) (P < 0.01); The expression of endostatin was closely related to the size of primary tumor, distant metastasis of the cancer, P-TNM stages and cell differentiation of lung cancer (P < 0.05), but not to the histological classification, lymph node status, location of the tumor, smoking or not, age and sex of the patients with lung cancer (P > 0.05).
  
  
  CONCLUSIONS
  The expression of endostatin in NSCLC cancer tissues might be helpful to evaluate the biological behavior of lung cancer.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
authors.forename: Shangfu
authors.initials: S
authors.lastname: Zhang
authors.forename: Lunxu
authors.initials: L
authors.lastname: Liu
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Xue
authors.forename: Guowei
authors.initials: G
authors.lastname: Che