title: [Plasma malondialdehyde may not predict mortality in patient with chronic kidney disease].
abstract: The role of oxidative stress in patients with chronic kidney disease (CKD) as a potential marker of morbidity and mortality remains poorly evaluated. The aim of the present study aims was thus: to determine plasma levels of malondialdehyde (MDA), end product of lipid peroxidation in patients at different CKD stages (predialysis and dialysis); to evaluate the association between plasma MDA levels and vascular disease or overall and cardiovascular mortality. Plasma MDA levels evaluated by HPLC, pulse wave velocity, aortic calcification score were evaluated in 94 CKD patients (67±13 years, 54% males, 29% at CKD stages 2-3, 32% at stages 4-5, 39% at stage 5D) prospectively followed for mortality. We observed that the plasma MDA levels were increased in patient with CKD and augmented progressively with CKD stages. However, we did not find any independent association between plasma levels of MDA and pulse wave velocity, aortic calcification score, or overall and cardiovascular mortality. Our results suggest that plasma MDA is not a useful biomarker in CKD patients.
authors.affiliation: Service de pharmacologie, centre de recherche clinique, CHU Amiens-Sud, avenue René-Laennec, 80054 Amiens, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Terrier-Lenglet
authors.forename: Aude
authors.initials: A
authors.lastname: Nollet
authors.forename: Sophie
authors.initials: S
authors.lastname: Liabeuf
authors.forename: Daniela V
authors.initials: DV
authors.lastname: Barreto
authors.forename: Michel
authors.initials: M
authors.lastname: Brazier
authors.forename: Horst-Dieter
authors.initials: HD
authors.lastname: Lemke
authors.forename: Raymond
authors.initials: R
authors.lastname: Vanholder
authors.forename: Gabriel
authors.initials: G
authors.lastname: Choukroun
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Massy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D018450:Disease Progression; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000401:mortality*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D006435:Renal Dialysis / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde