title: Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
abstract: Lung cancer is the foremost cause of cancer mortality and is a growing economic burden worldwide. Fisetin (3,7,3',4'-tetrahydroxyflavone), a naturally occurring flavonoid is found in vegetables and fruits possesses anti-oxidative, anti-inflammatory and anti-proliferative effects in a wide variety of cancer. In the present study it is hypothesized that fisetin may provide chemopreventive as well as chemotherapeutic effects against experimental lung carcinogenesis. The present study was designed to investigate whether fisetin confers anti-cancer action against benzo(a)pyrene [B(a)P] induced lung carcinogenesis. Treatment with fisetin significantly reduced the degree of histological lesions, restored the levels of lipid peroxidation (LPO), enzymic and non-enzymic anti-oxidants in B(a)P-induced mice. Anti-proliferative efficacy of fisetin was assessed by immunohistochemical analysis of proliferating cell nuclear antigen (PCNA) in B(a)P induced mice showed increased PCNA expression which is restored upon fisetin administration. Together, our results depicts that fisetin can be used as chemopreventive agent against lung cancer.
authors.affiliation: Department of Biotechnology, University of Madras, Guindy Campus, Chennai - 600 025, Tamilnadu, India.
authors.forename: Nagaiya
authors.initials: N
authors.lastname: Ravichandran
authors.forename: Gopalakrishnan
authors.initials: G
authors.lastname: Suresh
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Ramesh
authors.forename: Ganesan Vijaiyan
authors.initials: GV
authors.lastname: Siva
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols; D015227:Lipid Peroxidation; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D018809:Proliferating Cell Nuclear Antigen
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D044948:Flavonols; D018809:Proliferating Cell Nuclear Antigen; D001564:Benzo(a)pyrene; C017875:fisetin