title: Time-lapse imaging of neural development: zebrafish lead the way into the fourth dimension.
abstract: Time-lapse imaging is often the only way to appreciate fully the many dynamic cell movements critical to neural development. Zebrafish possess many advantages that make them the best vertebrate model organism for live imaging of dynamic development events. This review will discuss technical considerations of time-lapse imaging experiments in zebrafish, describe selected examples of imaging studies in zebrafish that revealed new features or principles of neural development, and consider the promise and challenges of future time-lapse studies of neural development in zebrafish embryos and adults.
authors.affiliation: Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California, USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rieger
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Alvaro
authors.initials: A
authors.lastname: Sagasti
mesh_terms: D000818:Animals; D015509:Developmental Biology / Q000295:instrumentation / Q000379:methods; D018613:Microscopy, Confocal; D057054:Molecular Imaging; D009446:Neurobiology / Q000295:instrumentation / Q000379:methods; D055495:Neurogenesis / Q000502:physiology*; D059008:Time-Lapse Imaging / Q000639:trends; D015027:Zebrafish / Q000196:embryology