title: Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature.
abstract: CXCR4 and CXCR7 chemokine receptors, and their ligands CXCL11 and CXCL12, have been often involved in tumor cell proliferation and survival. We report the expression pattern of these ligand/receptor pairs in 22 human meningiomas. High CXCR7 and CXCL12 expression was associated with high-proliferative tumors. CXCR7 levels were correlated to the content of both ligands, suggesting a possible autocrine regulation. CXCR4 and CXCL12 were homogeneously expressed within tumor cells, while CXCR7 was mainly detected in tumor endothelial cells and CXCL11 in pericytes. Our results highlight the preferential CXCR7 and CXCL12 expression within more aggressive tumors and the possible role of CXCR7 in meningioma vascularization.
authors.affiliation: Laboratory of Pharmacology, Department of Oncology Biology and Genetics, University of Genova, 16132 Genova, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Würth
authors.forename: Federica
authors.initials: F
authors.lastname: Barbieri
authors.forename: Adriana
authors.initials: A
authors.lastname: Bajetto
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pattarozzi
authors.forename: Monica
authors.initials: M
authors.lastname: Gatti
authors.forename: Carola
authors.initials: C
authors.lastname: Porcile
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Zona
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Ravetti
authors.forename: Renato
authors.initials: R
authors.lastname: Spaziante
authors.forename: Tullio
authors.initials: T
authors.lastname: Florio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology; D004388:Dura Mater / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D007211:Indoles; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008579:Meningioma / Q000378:metabolism / Q000473:pathology*; D055806:Microvessels; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism; D054387:Receptors, CXCR / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013223:Statistics as Topic
chemical_list: C501896:ACKR3 protein, human; D018952:Antigens, CD34; D007211:Indoles; D019394:Ki-67 Antigen; D012333:RNA, Messenger; D054387:Receptors, CXCR; C007293:DAPI