title: Facilitation of tactile working memory by top-down suppression from prefrontal to primary somatosensory cortex during sensory interference.
abstract: Tactile working memory (WM) is improved by increasing top-down suppression of interfering sensory processing in S1 via a link from the middle frontal gyrus (MFG) to S1. Here we studied in healthy subjects whether the efficacy of top-down suppression varies with submodality of sensory interference. Navigated stimulation of the MFG-S1 link significantly improved tactile WM performance when accompanied by tactile but not visual interference of memory maintenance.
authors.affiliation: Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland.
authors.forename: Petri
authors.initials: P
authors.lastname: Savolainen
authors.forename: Synnöve
authors.initials: S
authors.lastname: Carlson
authors.forename: Robert
authors.initials: R
authors.lastname: Boldt
authors.forename: Tuomas
authors.initials: T
authors.lastname: Neuvonen
authors.forename: Henri
authors.initials: H
authors.lastname: Hannula
authors.forename: Jaana
authors.initials: J
authors.lastname: Hiltunen
authors.forename: Oili
authors.initials: O
authors.lastname: Salonen
authors.forename: Yuan-Ye
authors.initials: YY
authors.lastname: Ma
authors.forename: Antti
authors.initials: A
authors.lastname: Pertovaara
mesh_terms: D000328:Adult; D056324:Diffusion Tensor Imaging; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult