title: Anti-inflammatory, antioxidant and antifungal furanosesquiterpenoids isolated from Commiphora erythraea (Ehrenb.) Engl. resin.
abstract: The topical anti-inflammatory, free radical scavenging and antifungal activities of essential oils and extracts of Commiphora erythraea (Ehrenb.) Engl. resin were investigated. The hexane extract significantly inhibited oedema when applied topically in Croton oil-induced ear oedema assay in mice. The same extract showed antioxidant activity in DPPH radical scavenging assay. A bioguided separation of the hexane extract led to the isolation of furanosesquiterpenoids 1 and 2 that showed a weak antifungal activity, while compounds 3-5 resulted to be antioxidant (EC(50) 4.28, 2.56 and 1.08 mg/mL, respectively) and anti-inflammatory (30, 26 and 32% oedema reduction, respectively).
authors.affiliation: Dipartimento di Scienze dell'Uomo, dell'Ambiente e della Natura, Sez. Biologia Vegetale, Università degli Studi di Urbino Carlo Bo, Via Bramante, 28-61029 Urbino, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Fraternale
authors.forename: Silvio
authors.initials: S
authors.lastname: Sosa
authors.forename: Donata
authors.initials: D
authors.lastname: Ricci
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Federica
authors.initials: F
authors.lastname: Messina
authors.forename: Sabrina
authors.initials: S
authors.lastname: Tomasini
authors.forename: Francesca
authors.initials: F
authors.lastname: Montanari
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Marcotullio
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis*; D000935:Antifungal Agents / Q000032:analysis*; D000975:Antioxidants / Q000032:analysis*; D029744:Commiphora / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013729:Terpenes / Q000032:analysis*
chemical_list: D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000975:Antioxidants; D009822:Oils, Volatile; D012116:Resins, Plant; D012717:Sesquiterpenes; D013729:Terpenes