title: Altered functional connectivity in default mode network in absence epilepsy: a resting-state fMRI study.
abstract: Dysfunctional default mode network (DMN) has been observed in various mental disorders, including epilepsy (see review Broyd et al. [2009]: Neurosci Biobehav Rev 33:279–296). Because interictal epileptic discharges may affect DMN, resting-state fMRI was used in this study to determine DMN functional connectivity in 14 healthy controls and 12 absence epilepsy patients. To avoid interictal epileptic discharge effects, testing was performed within interictal durations when there were no interictal epileptic discharges. Cross-correlation functional connectivity analysis with seed at posterior cingulate cortex, as well as region-wise calculation in DMN, revealed decreased integration within DMN in the absence epilepsy patients. Region-wise functional connectivity among the frontal, parietal, and temporal lobe was significantly decreased in the patient group. Moreover, functional connectivity between the frontal and parietal lobe revealed a significant negative correlation with epilepsy duration. These findings indicated DMN abnormalities in patients with absence epilepsy, even during resting interictal durations without interictal epileptic discharges. Abnormal functional connectivity in absence epilepsy may reflect abnormal anatomo-functional architectural integration in DMN, as a result of cognitive mental impairment and unconsciousness during absence seizure.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Luo
authors.forename: Qifu
authors.initials: Q
authors.lastname: Li
authors.forename: Yongxiu
authors.initials: Y
authors.lastname: Lai
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.forename: Yun
authors.initials: Y
authors.lastname: Qin
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
authors.forename: Shasha
authors.initials: S
authors.lastname: Li
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D000293:Adolescent; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D004832:Epilepsy, Absence / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D012146:Rest / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen