title: Unusual tigliane diterpenes from Euphorbia grandicornis.
abstract: Phytochemical study of the aerial parts of Euphorbia grandicornis led to the isolation of two new tigliane diterpenes, 16-angeloyloxy-13α-isobutanoyloxy-4β,9α,20-trihydroxytiglia-1,5-diene-3,7-dione (1) and 16-angeloyloxy-13α-isobutanoyloxy-4β,9α,7β-trihydroxytiglia-1,5-dien-3-one (2). The structures and relative configuration of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments ((1)H NMR, JMOD, (1)H-(1)H COSY, NOESY, HSQC, and HMBC), mass spectrometry, and comparison with literature data. The biogenesis of 1 and 2 with respect to the unusual 5-en-7-one and 5-en-7-ol moieties is also discussed.
authors.affiliation: Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged 6720, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Forgo
authors.forename: Dóra
authors.initials: D
authors.lastname: Rédei
authors.forename: Zsanett
authors.initials: Z
authors.lastname: Hajdu
authors.forename: Pál
authors.initials: P
authors.lastname: Szabó
authors.forename: László
authors.initials: L
authors.lastname: Szabó
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
mesh_terms: D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D028481:Euphorbia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C558897:16-angeloyloxy-13alpha-isobutanoyloxy-4beta,9alpha,20-trihydroxytiglia-1,5-diene-3,7-dione; C558898:16-angeloyloxy-13alpha-isobutanoyloxy-4beta,9alpha,7beta-trihydroxytiglia-1,5-dien-3-one; D004224:Diterpenes