title: Unusual systemic signs in a dog with sterile neutrophilic-macrophagic lymphadenitis and nodular panniculitis.
abstract: A 7 mo old female English springer spaniel was presented with diarrhea, vomiting, apathy, and hyperthermia. Further examinations revealed generalized lymphadenomegaly consistent with sterile neutrophilic-macrophagic lymphadenitis and pulmonary involvement. Subcutaneous nodules developed one day after presentation. Histology was consistent with sterile idiopathic nodular panniculitis and vasculitis. No infectious organism was isolated. The dog responded to prednisolone, but relapsed during medication tapering. Cyclosporine had to be added to control the disease. No further relapse had occurred 98 wk after the first presentation. This is an unusual presentation of a systemic sterile neutrophilic-macrophagic lymphadenitis with nodular panniculitis and vasculitis associated with gastrointestinal and pulmonary signs.
authors.affiliation: Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland. jdandrieux@gmail.com
authors.forename: Julien R S
authors.initials: JR
authors.lastname: Dandrieux
authors.forename: Katrin
authors.initials: K
authors.lastname: Timm
authors.forename: Petra J
authors.initials: PJ
authors.lastname: Roosje
authors.forename: Monika
authors.initials: M
authors.lastname: Welle
authors.forename: Judith
authors.initials: J
authors.lastname: Howard
authors.forename: Andreas
authors.initials: A
authors.lastname: Brühschwein
authors.forename: Thierry
authors.initials: T
authors.lastname: Francey
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001772:Blood Cell Count / Q000662:veterinary; D016572:Cyclosporine / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008199:Lymphadenitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D010201:Panniculitis, Nodular Nonsuppurative / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone