title: Aporphine alkaloids and cytotoxic lignans from the roots of Illigera luzonensis.
abstract: Six aporphine alkaloids, (+)-(S)-N-butyrylcaaverine (1), (+)-(S)-N-propionylcaaverine (2), (+)-(S)-N-acetylcaaverine (3), (+)-(6aR,7R)-N-butyrylnorushinsunine (4), (+)-(6aR,7R,E)-N-(but-2-enoyl)norushinsunine (5), and N-formyldehydrocaaverine (6) were isolated from the roots of Illigera luzonensis, together with 16 known compounds. Their structures were determined through spectroscopic and MS analyses. Among the isolates, (-)-deoxypodophyllotoxin (13) was the most cytotoxic, with IC(50) values of 0.0057, 0.0067, 0.00004, and 0.0035μg/mL, respectively, against DLD-1, CCRF-CEM, HL-60, and IMR-32 cell lines. In addition, (-)-yatein (12) exhibited cytotoxic effects, with IC(50) values of 0.81, 0.20, and 0.59μg/mL, respectively, against DLD-1, CCRF-CEM, and HL-60 cell lines.
authors.affiliation: Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Hsin-Chih
authors.initials: HC
authors.lastname: Hung
authors.forename: Ping-Jyun
authors.initials: PJ
authors.lastname: Sung
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Wen-Lung
authors.initials: WL
authors.lastname: Kuo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D049935:Hernandiaceae / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D001060:Aporphines; D003603:Cytotoxins; D017705:Lignans