title: Rubesanolides A and B: diterpenoids from Isodon rubescens.
abstract: From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique β-lactone subgroup. This is the first discovery for a natural diterpene having rings A, B, and C in chair, boat, and twist-chair conformations, respectively. The structures were elucidated by analysis of spectroscopic data, and the absolute configuration of 1 was determined by X-ray diffraction.
authors.affiliation: Guiyang College of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zou
authors.forename: Lutai
authors.initials: L
authors.lastname: Pan
authors.forename: Qiji
authors.initials: Q
authors.lastname: Li
authors.forename: Junhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Jianxin
authors.initials: J
authors.lastname: Pu
authors.forename: Ping
authors.initials: P
authors.lastname: Yao
authors.forename: Ningbo
authors.initials: N
authors.lastname: Gong
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Tamara P
authors.initials: TP
authors.lastname: Kondratyuk
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: Harry H S
authors.initials: HH
authors.lastname: Fong
authors.forename: Hongjie
authors.initials: H
authors.lastname: Zhang
authors.forename: Handong
authors.initials: H
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D020014:K562 Cells; D007783:Lactones / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007783:Lactones; C558618:rubesanolide A; C558619:rubesanolide B