title: The Woven EndoBridge: a new aneurysm occlusion device.
abstract: OBJECTIVE
  The WEB device is an intrasaccular ellipsoid braided-wire embolization device designed to provide flow disruption along the aneurysm neck. The purpose of this study was to evaluate, in an in vivo aneurysm model, the acute and chronic performance of the WEB device regarding immediacy, degree, and durability of aneurysm occlusion.
  
  
  METHODS
  The WEB device was implanted in 24 elastase-induced aneurysms in New Zealand white rabbits and followed for 1, 3, 6, and 12 months (n = 6 at all time points). Degree of intra-aneurysmal flow disruption was graded on a 4-point scale based on DSA within 10 minutes following device implantation. Chronic aneurysm occlusion was rated by using a 3-point scale. All aneurysms were harvested for histologic analysis.
  
  
  RESULTS
  Immediate postimplant grade 1 (complete flow cessation) was noted in 7 (29%) of 24 cases. Grade 2 (near-complete flow cessation) was noted in 13 (54%) of 24 cases. At follow-up, complete occlusion was noted in 8 (33%) of 24 cases. Near-complete aneurysm occlusion was noted in 14 (58%) of 24 cases, while incomplete occlusion was noted in 2 (8%) cases. Stable aneurysm occlusion was present in 7 (29%) of 24 cases; progressive occlusion, in 14 (58%); and recanalization, in 3 (13%) cases. Histologic findings included aneurysm cavities filled with organized thrombus with connective tissue across the aneurysm neck.
  
  
  CONCLUSIONS
  The WEB device in experimental aneurysms demonstrated promising rates of immediate and long-term aneurysm occlusion.
authors.affiliation: Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Y H
authors.initials: YH
authors.lastname: Ding
authors.forename: D A
authors.initials: DA
authors.lastname: Lewis
authors.forename: R
authors.initials: R
authors.lastname: Kadirvel
authors.forename: D
authors.initials: D
authors.lastname: Dai
authors.forename: D F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D000818:Animals; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D002532:Intracranial Aneurysm / Q000139:chemically induced* / Q000628:therapy*; D023421:Models, Animal; D010196:Pancreatic Elastase; D011817:Rabbits; D013045:Species Specificity; D016896:Treatment Outcome
chemical_list: D010196:Pancreatic Elastase