title: WITHDRAWN: Eradication of Helicobacter pylori for non-ulcer dyspepsia.
abstract: BACKGROUND
  Helicobacter pylori (H pylori) is the main cause of peptic ulcer disease. The role of H pylori in non-ulcer dyspepsia is less clear.
  
  
  OBJECTIVE
  To determine the effect of H pylori eradication on dyspepsia symptoms in patients with non-ulcer dyspepsia.
  
  
  METHODS
  Trials were identified through electronic searches of the Cochrane Controlled Trials Register (CCTR), MEDLINE, EMBASE, CINAHL and SIGLE, using appropriate subject headings and keywords, searching bibliographies of retrieved articles, and through contacts with experts in the fields of dyspepsia and with pharmaceutical companies.
  
  
  METHODS
  All parallel group randomised controlled trials (RCTs) comparing drugs to eradicate H pylori with placebo or other drugs known not to eradicate H pylori for patients with non-ulcer dyspepsia.
  
  
  METHODS
  Data were collected on individual and global dyspeptic symptom scores, quality of life measures and adverse effects. Dyspepsia outcomes were dichotomised into minimal/resolved versus same/worse symptoms.
  
  
  RESULTS
  Twenty one randomised controlled trials were included in the systematic review. Eighteen trials compared antisecretory dual or triple therapy with placebo antibiotics +/- antisecretory therapy, and evaluated dyspepsia at 3-12 months. Seventeen of these trials gave results as dichotomous outcomes evaluating 3566 patients and there was no significant heterogeneity between the studies. There was a 10% relative risk reduction in the H pylori eradication group (95% CI = 6% to 14%) compared to placebo. The number needed to treat to cure one case of dyspepsia = 14 (95% CI = 10 to 25). A further three trials compared Bismuth based H pylori eradication with an alternative pharmacological agent. These trials were smaller and had a shorter follow-up but suggested H pylori eradication was more effective than either H2 receptor antagonists or sucralfate in treating non-ulcer dyspepsia.
  
  
  CONCLUSIONS
  H pylori eradication therapy has a small but statistically significant effect in H pylori positive non-ulcer dyspepsia. An economic model suggests this modest benefit may still be cost-effective but more research is needed.
authors.affiliation: Department of Medicine, Division of Gastroenterology, McMaster University, 1200 Main Street West, Room 4W8E, Hamilton, Ontario, Canada, L8N 3Z5.
authors.forename: Paul
authors.initials: P
authors.lastname: Moayyedi
authors.forename: Shelly
authors.initials: S
authors.lastname: Soo
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Deeks
authors.forename: Brendan
authors.initials: B
authors.lastname: Delaney
authors.forename: Adam
authors.initials: A
authors.lastname: Harris
authors.forename: Michael
authors.initials: M
authors.lastname: Innes
authors.forename: R
authors.initials: R
authors.lastname: Oakes
authors.forename: Sue
authors.initials: S
authors.lastname: Wilson
authors.forename: A
authors.initials: A
authors.lastname: Roalfe
authors.forename: Cathy
authors.initials: C
authors.lastname: Bennett
authors.forename: David
authors.initials: D
authors.lastname: Forman
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000188:drug therapy* / Q000382:microbiology; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D016032:Randomized Controlled Trials as Topic
chemical_list: D000900:Anti-Bacterial Agents; D005765:Gastrointestinal Agents