title: Meta-analysis of ACE gene I/D polymorphism and bipolar disorder susceptibility.
abstract: BACKGROUND
  A number of studies have been conducted to explore the association between ACE gene insertion/deletion (I/D) polymorphism and bipolar disorder (BPD). However, the reported results were conflicting.
  
  
  OBJECTIVE
  The aim of our study was to find evidence on whether ACE gene I/D polymorphism is associated with BPD using a meta-analysis.
  
  
  METHODS
  Data were collected from the following electronic databases: Pubmed, Elsevier Science Direct, Cochrane Library, CBM, CNKI and Wanfang. Meta-analysis was performed for genotypes ID vs. II, DD vs. II, DD vs. ID + II, ID + DD vs. II, and D allele vs. I allele in a fixed/random effect model.
  
  
  RESULTS
  Seven studies that included data from 605 cases and 1541 controls were identified. When all groups were pooled, we did not detect the association of ACE gene I/D polymorphism with BPD (P > 0.05). In the subgroup analysis, we did not detect the association of ACE gene I/D polymorphism with BPD in Caucasians (P > 0.05). An association of ACE gene I/D polymorphism with BPD was found in Asians for the contrast of DD vs. ID + II (OR = 2.01, 95% CI 1.08-3.74, P = 0.03), but not for other contrasts (P > 0.05).
  
  
  CONCLUSIONS
  This meta-analysis suggests that there may be an association of ACE gene I/D polymorphism with BPD in Asians. Further studies are still needed in Asians.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Zou
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Feng
authors.forename: Wen-Fei
authors.initials: WF
authors.lastname: Li
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Pan
authors.forename: Fen
authors.initials: F
authors.lastname: Huang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D044465:White People / Q000235:genetics
chemical_list: D007703:Peptidyl-Dipeptidase A