title: The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats.
abstract: Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.
authors.affiliation: Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4., 9700 Szombathely, Hungary. zskovacs@ttk.nyme.hu
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Kovács
authors.forename: András
authors.initials: A
authors.lastname: Czurkó
authors.forename: Katalin A
authors.initials: KA
authors.lastname: Kékesi
authors.forename: Gábor
authors.initials: G
authors.lastname: Juhász
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004832:Epilepsy, Absence / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009068:Movement / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004121:Dimethyl Sulfoxide