title: Clinical research in systemic lupus erythematosus: immediate relevance to clinical practice.
abstract: Systemic lupus erythematosus remains a challenge because of its diverse presentations, variable natural history, and lack of uniform response to treatment. True remission is very rare. Reliance on corticosteroid treatment leads to unwanted long-term toxicity. Great advances have been made in the early detection of lupus nephritis and in treatment. Greater appreciation of cognitive impairment and of lupus myelitis is now possible. Pregnancy risks are better characterized. However, the greatest unmet challenge remains atherosclerosis.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. mpetri@jhmi.edu
authors.forename: Michelle
authors.initials: M
authors.lastname: Petri
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000209:etiology; D035843:Biomedical Research; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008181:Lupus Nephritis / Q000473:pathology; D011241:Prednisone / Q000009:adverse effects; D011247:Pregnancy; D011248:Pregnancy Complications; D011364:Professional Practice; D016032:Randomized Controlled Trials as Topic; D057170:Translational Research, Biomedical
chemical_list: D011241:Prednisone