title: Selective drug trace detection with low-field NMR.
abstract: Advances with para-hydrogen induced polarization open up new fields of applications for portable low-field NMR. Here we report the possibility of tracing drugs down to the micromolar regime. We could selectively polarize nicotine quantities similar to those found in one cigarette. Also less than 1 mg of harmine, a drug used for treatment of Parkinson's disease, and morphine extracted from an opium solution were detectable after polarization with para-hydrogen in single-scan (1)H-experiments. Moreover, we demonstrate the possibility to selectively enhance and detect the (1)H-signal of drug molecules with PHIP in proton rich standard solutions that would otherwise mask the (1)H NMR signal of the drug.
authors.affiliation: Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany. stgloeggler@gmx.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Glöggler
authors.forename: Meike
authors.initials: M
authors.lastname: Emondts
authors.forename: Johannes
authors.initials: J
authors.lastname: Colell
authors.forename: Rafael
authors.initials: R
authors.lastname: Müller
authors.forename: Bernhard
authors.initials: B
authors.lastname: Blümich
authors.forename: Stephan
authors.initials: S
authors.lastname: Appelt
mesh_terms: D004350:Drug Residues / Q000032:analysis*; D006247:Harmine / Q000032:analysis; D006859:Hydrogen / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009020:Morphine / Q000032:analysis; D009538:Nicotine / Q000032:analysis; D009892:Opium / Q000737:chemistry; D014026:Nicotiana / Q000737:chemistry
chemical_list: D006247:Harmine; D009538:Nicotine; D009020:Morphine; D006859:Hydrogen; D009892:Opium